---
language: en
license: cc-by-4.0
tags:
  - biology
  - rna-seq
  - gene-expression
  - treatment-response
  - biomedical
size_categories:
  - 1K<n<10K
---

# GEO RNA-seq Treatment Response Dataset

Pre-treatment RNA-seq studies with patient treatment response annotations,
standardised to Entrez gene IDs and binary responder/non-responder labels.

## Studies included (1 total, updated 2026-05-04)

- **GSE91061** (bulk):  | n=51 | advanced melanoma (unresectable or metastatic) | Nivolumab (anti-PD-1) 3 mg/kg IV every 2 weeks; CA209-038 clinical study (NCT01621490); cohort includes ipilimumab-naive (n=33) and ipilimumab-progressed (n=35) patients

## Loading

```python
from datasets import load_dataset, get_dataset_config_names

# List all studies
configs = get_dataset_config_names("Cgensbigler/geo-treatment-response")

# Load one study
ds = load_dataset("Cgensbigler/geo-treatment-response", name="gse91061_bulk_expression")
```

## Schema

Each study config has two splits: `*_expression` (patients × Entrez gene IDs)
and `*_metadata` (patient clinical + response annotations).

Response column: `response_binary` (1=responder, 0=non-responder, -1=ambiguous).