---
license: mit
language:
- en
pretty_name: ABX-RM-007 Heteroresistance Population Shift
tags:
- antibiotics
- resistance
- heteroresistance
- population-shift
- tabular
task_categories:
- tabular-classification
size_categories:
- n<1k
---

ABX-RM-007 Heteroresistance Population Shift

Purpose

Detect growth of a minor resistant subpopulation before it becomes dominant and before MIC crosses the resistant cutoff.

Core pattern

- resistant_subpop_frac crosses a minor threshold
- MIC stays below resistant_mic_cutoff_mg_L at that time
- later resistant_subpop_frac becomes dominant
- later MIC crosses resistant_mic_cutoff_mg_L

Files

- data/train.csv
- data/test.csv
- scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

- row_id
- series_id
- timepoint_h
- organism
- strain_id
- drug_name
- resistant_subpop_frac
- mic_drug_mg_L
- resistant_mic_cutoff_mg_L
- media
- assay_method
- source_type
- hetero_shift_signal
- earliest_hetero_shift

Labels

- hetero_shift_signal
  - 1 for rows at or after the first confirmed shift point

- earliest_hetero_shift
  - 1 only for the first detected shift row in that series

Scorer logic in v1

- baseline is timepoint 0
- candidate early shift point
  - resistant_subpop_frac at least 0.20
  - MIC at most 2x baseline
  - MIC still below resistant cutoff
  - exclude spike then snapback artifacts
- confirmation
  - later resistant_subpop_frac reaches at least 0.70
  - later MIC crosses resistant cutoff

Evaluation

Run

- python scorer.py --path data/test.csv