---
license: mit
language:
- en
pretty_name: ABX-RM-010 Regulatory Network Rewiring
tags:
- antibiotics
- resistance
- regulation
- stress-response
- tabular
task_categories:
- tabular-classification
size_categories:
- n<1k
---

ABX-RM-010 Regulatory Network Rewiring

Purpose

Detect sustained decoupling between expected stress regulation and measured regulator activity before MIC crosses a resistant cutoff.

Core pattern

- stress_index high
- decoupling_error stays high across consecutive timepoints
- MIC stays below resistant_mic_cutoff_mg_L during the decoupling window
- later MIC crosses resistant_mic_cutoff_mg_L

Files

- data/train.csv
- data/test.csv
- scorer.py

Schema

Each row is one timepoint in a within strain series.

Required columns

- row_id
- series_id
- timepoint_h
- organism
- strain_id
- drug_name
- reg_network
- stress_index
- regulator_activity_rel
- expected_activity_rel
- decoupling_error
- mic_drug_mg_L
- resistant_mic_cutoff_mg_L
- media
- assay_method
- source_type
- rewiring_signal
- earliest_rewiring

Labels

- rewiring_signal
  - 1 for rows at or after the first confirmed rewiring point

- earliest_rewiring
  - 1 only for the first detected rewiring row in that series

Scorer logic in v1

- baseline is timepoint 0
- candidate rewiring point
  - stress_index at least 0.80
  - decoupling_error at least 0.90 at two consecutive timepoints
  - MIC at that point below cutoff and at most 2x baseline
  - exclude decoupling spike then snapback artifacts
- confirmation
  - later MIC crosses resistant cutoff

Evaluation

Run

- python scorer.py --path data/test.csv