id,population_shift,protocol_deviation_rate,site_variance_level,endpoint_fragility,signal,label 1,none,low,low,low,Population stable with low deviations and uniform sites. Endpoint robust,0 2,minor,medium,low,low,Small population shift with manageable deviations. Endpoint remains robust,1 3,minor,medium,medium,medium,Population shift plus site drift creates early endpoint fragility,1 4,major,high,medium,high,Major population shift with high deviations undermines endpoint validity,2 5,none,high,high,high,High deviations and site variance fragment endpoint despite stable population,2 6,major,low,medium,medium,Population shifts but deviations low. Endpoint pressured by site effects,1 7,major,medium,high,high,All nodes misalign. Endpoint becomes fragile and unstable,2 8,minor,low,high,medium,Population mostly stable but site variance drives fragility,1 9,none,medium,high,high,Site variance dominates and endpoint credibility breaks,2 10,minor,high,low,medium,Deviations rising with mild population shift creates endpoint fragility,2