Traumatic dislocation of the hip joint in children. Between 1949 and 1972, 24 children under the age of 16 years were admitted to Middlemore Hospital with traumatic dislocation of a hip. Half of these were between 12 and 15 years of age, and there was a predominance of boys in the ratio of 7:1. A survey of these children supports the view that the hip joint of a child becomes dislocated more readily than that of an adult.


The treatment of priapism by cavernosospongiosal shunt: results of operation in five patients. The cavernosospongiosal shunt operation is an effective method of treatment of priapism. Experience with five cases has led the writers to suggest early operation, avoidance of needle aspiration and the use of steroids.


Post-cholecystectomy wound morbidity: the influence of electrosurgery. The wound morbidity patterns following elective cholecystectomy were reviewed in 235 patients. The method used to divide the musculo-aponeurotic layers of the abdominal wall did not influence the overall wound morbidity rate. There was, however, a disproportionate number of males with wound morbidity following an electrosurgical incision. The explanation may be related to the increased rectus muscle mass in males.


Fracture of the odontoid process.

Fracture of the odontoid process. A review of 26 cases of odontoid fractures has been carried out. Late diagnosis and consequent delay in treatment were found to be important causes of non-union. Myelopathy in odontoid fractures is of two types. One type is that present immediately after injury, while the other is delayed. In treatment of long-standing cases, only fusion without posterior decompression should be done. If the latter procedure is carried out, it can produce medullospinal haematomyelia with respiratory arrest and tetraplegia. In the performance of atlanto-axial fusion, the technique of bone grafting and the use of thick wires need emphasis.


Giant intracranial epidermoid tumour: a singular pearl? The chronic benign course and occasional gigantic size of posterior fossa epidermoids are illustrated by a case report, and the features of these tumours are reviewed.


Advanced intraabdominal pregnancy: case report with a brief review of the literature. We here present a case of advanced intraabdominal pregnancy diagnosed at laparotomy. A brief review of the literature is included, with special reference to the problems of diagnosis and of management of the placenta.


Urgent aortic valve replacement in disseminated gonococcaemia associated with sinus of Valsalva aneurysm and fistula formation. A patient with aortic valve disruption due to gonococcal endocarditis and associated with a sinus of Valsalva aneurysm and fistula into the right ventricle is described. The rarity of this combination of conditions and the place of surgery in their management are discussed.


Volvulus of the transverse colon: a postoperative complication of truncal vagotomy and gastrojejunostomy. An instance of volvulus of the transverse colon in the postoperative period following truncal vagotomy and anterior gastrojejunostomy is reported. The clinical features of volvulus of the transverse colon are sudden onset of abdominal colic, distension and vomiting. A plain X-ray film of the abdomen is diagnostic. Laparotomy is recommended, followed by untwisting alone, or untwisting and colostomy when the bowel is viable, or resection with a transverse  colostomy and mucous fistula as a first stage when the bowel is gangrenous.


Systeme international d'unites (s.i. units). The metric system is now used in most countries for expressing measurements in the health care field. The original metric system based on lenght (centimetre), mass (gramme) and time (second) has proved inadequate. The International Bureau of Weights and Measures, which has the ultimate responsibility for standarization of measlring systems, has revised and extended the metric system, through a series of general conferences on weights and measures, to the systeme International d'Unites (S.I.). This is now the internationally accepted language for measurements throughout science and industry.


A prospective trial of povodone iodine solution in the prevention of wound sepsis. In a prospective blind trial in patients undergoing intraabdominal surgery, instillation of povodone iodine (PVI) solution into the wound failed to reduce the incidence of wound sepsis.


Quality control in the Part I F.R.A.C.S. examination. The conduct of College examinations has seemed a mystery to many candidates. Both candidates and supervisors of training have echoed this concern with the R.A.C.S. new Part 1 examination. This paper describes the work of the Board of Examiners of the Royal Australasian College of Surgeons and the procedures by which the new Part 1 examination is constructed, administered, analysed and refined. It sets out how the examination has been developed into an educational instrument to provide feedback to candidates, to teachers and to examiners, so that each can improve his performance. In addition, the Board has acquired data from each candidate on his learning opportunities, and from each candidate's mentor on various performance characteristics of the candidate.


Epithelial odontogenic tumors.

Epithelial odontogenic tumors.


Value of the Swan-Ganz balloon cathether in the diagnosis of transposition of the great arteries in an adult.


Short term prognostic importance of hemodynamic parameters in acute myocardial infarction.


An analysis of the results of the Part 1. Examination for the F.R.A.C.S. An analysis of the results of the candidates undertaking the Part 1 F.R.A.C.S. examination between February 1973 and February 1975 inclusive is presented. Particular attention is paid to those who failed the examination at the first attempt, and their subsequent progress has been related to their performance at this time. The analysis forms the basis for the information which is now given to unsuccessful candidates and their clinical supervisors.


Unilateral hyperlucent lung (Swyer-James syndrome).


Teamwork.

Teamwork.


Some polycarboxylate cements. Thermal analytical studies.


Extraction wound sockets. Histological changes and paste packs--a trial.


Attitudes to prevention amongst dental practitioners. A comparison between the North and South of England.


The performance of adult alcoholics working for alcohol: a detailed operant analysis.


Reflections on the positive consequences of illicit drug usage by the younger generation.


Drug use and a social psychology of change.


Drinking and self-injury: toward untangling the dynamics.


Alcohol and blacks: survey of the periodical literature.


The Manson Evaluation as an indicator of heroin independence.


Testing predictive efficiency of patient classifications for methadone maintenance clients.


Methadone maintenance: a review and critique.


Dimensions of addict life-style after treatment.


Maintenance or suppression? A comparative look at the heroin addiction policies of Great Britain and the U.S.


Chondrosarcoma of the mandibular condyle. Report of a case with special reference to radiographic features. A case of chondrosarcoma of the mandibular condyle is described. With carefully taken tomographs, a diagnosis of chondrosarcoma of the mandibular condyle can be made with some degree of certainty, on radiological evidence alone. Chondrosarcomata of the mandibular condyle may manifest with the typical symptoms of the temporomandibular joint dysfunction syndrome. Tumours of the condyle can reach a large size without producing clinically obvious swellings. The literature pertaining to chondrosarcoma of the mandibular condyle is reviewed.


Bone cavities in fibro-osseous lesions.

Bone cavities in fibro-osseous lesions.


Haemangiopericytoma of the floor of the mouth: a case report.


Dermoid cyst of the lower lip: a case report.


Oral swelling in Sjögren's syndrome.

Oral swelling in Sjögren's syndrome. A case is reported of a 69-year-old female with Sjögren's syndrome who presented with a problem of interest to the oral surgeon. The clinical features and cryosurgical management of a rare cause of palatal swelling are described. The confusion that exists in the literature concerning the nomenclature of chronic inflammatory salivary gland lesions is discussed.


Surgical anatomy of the ascending ramus of the mandible. A study of identifying the position of the lingula of the mandible on the external surface is described. The study was undertaken in an attempt to avoid damage to the inferior dental neurovascular bundle during operative procedures on the ascending ramus.


Sterilisation of teeth for homogenous transplantation. Sterilisation of teeth for homogenous transplantation has been successfully achieved by combined ultrasonic waves and immersion in 6 per cent hydrogen peroxide. This combined treatment was found to have no harmful effect on the tooth integrity as indicated by enamel solubility, hardness, root canal seal and tooth size and weight. It is suggested the method offers the possibility of storing teeth in a "tooth bank".


Injury associated with wearing a crash helment incorporating facial protection.


The CRST syndrome (calcinosis, Raynaud's phenomenon, sclerodactyly and telangiectasia). The CRST syndrome is defined, and its relation to systemic sclerosis described. The literature referring to the condition is reviewed and a further case reported. Clinical and diagnostic features of the telangiectasia are emphasised, particularly in comparison with those of the similar condition, hereditary haemorrhagic telangiectasia.


Horner'sy syndrome and its significance in the management of head and neck trauma. The history, mechanism and aetiology of Horner'sy Syndrome is presented and the pharmacology of the pupil is discussed. The case reported is a rare combination of Horner's Syndrome in a patient who sustained bilateral fractures of the mandible and a chest injury. It is emphasised that the miotic changes in Horner's Syndrome, in combination with head injuries can lead to confusion in diagnosis and the potential anaesthetic hazards and their influence on the management of the facial injury are outlined.


The effect of an alcoholic injection for facial pain.


Dentinoma: a case report.

Dentinoma: a case report.


The mini clinic. Facial pain and things.


Infra-orbital paraesthesia following upper third molar removal.


Denturism.

Denturism.


Mouthrinsing project.

Mouthrinsing project.


The survey of dental hygiene in Michigan: distribution of employed hygienists.


Fulfillment. Can you achieve it as a dental assistant?


Money. How rich is rich.

Money. How rich is rich.


Your memory. Here's how you can improve it!


Distractions. We have to keep our attention on primary issues--especially in '76.


Aggressive tax returns.

Aggressive tax returns.


Estate planning.

Estate planning.


Proper hiring means no firing.

Proper hiring means no firing.


Give us this day our daily bread.

Give us this day our daily bread.


The art of being convincing.

The art of being convincing.


Boudoir cheese cake.

Boudoir cheese cake.


The tooth fairy is a fictionalized fancy!


Another hiring gamble?

Another hiring gamble?


Confessions of a capitalist.

Confessions of a capitalist.


Equity versus debt financing.

Equity versus debt financing.


Location.

Location.


Public speaking.

Public speaking.


Evaluation of soft oryl (Getz) denture liner.


How to stop arid communications between dentist and patient.


Now--where are you?

Now--where are you?


Don't smoke smoke smoke that cigarette.

Don't smoke smoke smoke that cigarette.


How do you fill your appointment book?

How do you fill your appointment book?


A giant step.

A giant step.


A few practice management ideas.

A few practice management ideas.


Every new patient is a very important person.


When death necessitates selling a practice.


Report No. 3 on the Whiteriver Indian Project.


Smokers have everything...

Smokers have everything...


Childhood. You are what you're taught...almost!


A matter of time. What is important to us changes with time--sometimes!


Due process. What rights does it guarantee? What are its limitations?


What are the advantages and limitations of chairside denture linings?


Collections, nightmare or reality.

Collections, nightmare or reality.


What I know about women.

What I know about women.


When is the right time to take an associate?


Navy dentists take the office to their work!


Dental team harmony.

Dental team harmony.


The here-and-now!

The here-and-now!


Hypocrisy. The double standard can lead the way to national health insurance and dentursim.


Public speaking. How to become a better public speaker.


Financial finesse.

Financial finesse.


International women's year--1975.

International women's year--1975.


Wolf Cubs learn that teeth can last a lifetime.


Guest editorial. This story has seven years.


Microbial food poisoning.

Microbial food poisoning.


What is CFDE doing for dentistry in 1975?


Dental hygiene in Canada: A changing scene.


Conditions of employment in Canada.

Conditions of employment in Canada.


Dental hygienists are people too.

Dental hygienists are people too.


Copsystem: an educational proposal.

Copsystem: an educational proposal.


Cortically induced masticatory rhythm and its modification by tonic peripheral inputs in immolbilized cats. Repetitive cortical stimulation induced rhythmical masticatory jaw movement and masseteric nerve activity in cats with the spinal cord sectioned at the C2 level. Jaw depression alone did not induce any rhythmical jaw movement, but it turned the irregular jaw movement evoked by subthreshold cortical stimulation into the regular jaw movement as evoked by suprathreshold cortical stimulation. The cortically induced rhythmical masseseteric nerve activity could be induced even in immobilized condition and after cerebellectomy, although the rhythmical nerve activity was depressed in amplitude and the rhythm became slower than before immobilization. Tonic jaw depression after immobilization facilitated the tonic activity in the masseteric nerve and also induced a remarkable increase in the amplitude of the cortically evoked rhythmical nerve activity and a slight acceleration of the rhythm, leading to the same masticatory rhythm as before immobilization. It was concluded (1) that the cortically induced masticatory rhythm in cats is basically generated centrally and (2) that the tonic inputs from the muscle spindle in the jaw-closing muscles participate in the rhythm formation by supplying tonic excitatory inputs mainly to the jaw-closer motoneuron and also to the central rhythm generator.


Hydranencephaly -- report of a case--.

Hydranencephaly -- report of a case--.


Histological studies on early changes of the hamster gingival epithelium by N-nitrosomethylurea. The effect of repeated intragastric administration of N-nitrosomethylurea on the molar gingival epithelium of the hamster was investigated both higtologically and histoautoradiographically. Thickening and downward proliferation of the gingival epithelium were evident from the second month of the treatment, in the attachment epithelium and interdental epithelium. Subsequently, the apical part of the crevicular epithelium, epithelium of the oral  aspect of the gingiva, and the marginal crevicular epithelium thickened. About three months after the beginning of the administration, thickening, hyperkeratosis, and downward proliferation of the gingival epithelium were widespreas and proliferated epithelial cell nests were parakeratotic, often assuming a structure of keratotic cyst, which invaded the periodontium, accompanied with compressive resorption of the alveolar bone and involvement of bone marrows. Cellular atypia appeared three months after the first treatment, occasionally suggesting early  malignancy. Epithelial proliferation was generally not accompanied with any distinct inflammatory change. In the autoradiographic analysis, it was clearly noticed that labeled cells had increased in each epithelial zone before the histological changes became evident- The results of the present experiment were discussed in reference to the pathogenesis of gingival carcinoma.


Aseptic bone necrosis in Japanese divers. Medical examination was performed on the divers in Ohura for 7 years from 1969 to 1972. Aseptic bone necrosis was found in 268 of 450 divers (59.5%). Men with over 5 years of experience in diving were highly affected (more than 54.4%). These bone lesions were found most frequently in the proximal end of the femur and the humerus. There was a significantly higher incidence of bone lesions in the men who dived over 30 meters. In the group of men with one or more bone lesions, 73.1% were known to have been treated for bends. The bone, once exposed to a certain compression of air, would have a tendency to develop bone lesions even after cessation of diving. Type A2 (linear opacity) led to the structural failure of the joint surface of the femur and the humerus. Histopathological study was carried out on the sections of bone obtained from three autopsy cases and four operated cases. Formation of air bubbles in the bone marrow cavity seemed to be the most important as the cause for the occurrence of aseptic bone necrosis, and local circulatory disturbance might be the most responsible for the progression of the bone lesion.


Cleavage lines in the facial skin of Japanese cadavers. Since Langer published his work on the cleavage lines of the skin in 1861, many Japanese and foreign authors have referred to Langer's lines as the most appropriate guides for skin incisions giving minimum scarring after heelings, but it has recently been suggested that the cleavage lines of Langer do not constitute a suitable guide for making an incision. Furthermore, comparison with directions of the lines described in the published textbooks has shown some discrepancies in detail among these descriptions, especially in the face. Therefore, Japanese cleavage lines were examined in the facial region of seven male and four female Japanese cadavers, and the following results were obtained. 1) Forehead: The long axes of the cleavage lines tend to run transversely as a whole. 2) Eyelids: The lines run, drawing a concentric loops, aroung the eye-fissures. 3) Lips: The main direction of the lines on the upper lip is radial upwardly, and the lines radiate downward on the lower lip.


Dopaminergic function in Gilles de la Tourette's syndrome, Sydenham's chorea and torsion dystonia.


The safety assessment in the dog of a charcoal haemoperfusion column. 1. The safety of a carbon haemoperfusion column, Haemocol, has been studies in beagle dogs. 2. only minor changes in physiology, haematology and plasma chemistry were detected, except those associated with an improvement in clinical status. 3. It is concluded that haemoperfusion through this column is a safe and simple procedure, which merits evaluation in the treatment of severe drug overdose in man.


The specificity of antisera for the radioimmunoassay of arginine-vasopressin in human plasma and urine during water loading and dehydration. 1. Rabbit antisera against arginine-vasopressin (AVP) were evaluated for sensitivity and specificity in a radioimmunoassay based on the extraction of AVP from plasma and urine on to Florisil. 2. Comparison of the immunoreactivity of AVP with analogues showed that one antiserum (R2) reacted principally with the hexapeptide ring and another (R4) bound to the tripeptide tail and was reactive with some reduction and hydrolytic products of the native peptide. 3. The minimum amount of AVP measurable in the radioimmunoassay was 1 pg. The extraction of AVP from plasma and urine gave a recovery of 93 per cent (sd 5 per cent). A plasma sample repeatedly assayed with R2 gave a value of 1.4 ng/1 (sd 0.2, n=12). 4. The antiserum specific for the hexapeptide ring (R2) showed that in normal subjects AVP concentration ranged from 3.2 +/- 2.52 ng/1 after dehydration to 0.16 +/- 0.1 ng/1 after water loading.


Diminished albumin binding of zinc in serum of pregnant women. 1. Distribution of zinc between the metalloprotein alpha 2-macroglobulin and albumin was determined in samples of serum obtained from twenty-three women in their third trimester of pregnancy and eighteen women who were not pregnant. 2. The decrease observed in total serum zinc in the group of pregnant women could be accounted for in large part by a decreased concentration of albumin-bound zinc. 3. The concentration of serum albumin was lower in the pregnant women, thus hypoalbuminaemia, which is often invoked to explain hypozincaemia in pathological situations, may in part account for hypozincaemia in pregnancy. 4. The affinity of albumin for zinc added to serum from pregnant women was less than that of albumin from non-pregnant women. This was determined by competition experiments between albumin and glycine for zinc. Decreased affinity of serum albumin for zinc may also contribute to the hypozincaemia associated with pregnancy.


Analytical subcellular fractionation of jejunal biopsy specimens: methodology and characterization of the organelles in normal tissue. 1. Portions of closed jejunal biopsies were gently homogenized in isotonic sucrose or sorbitol and centrifuged at 800 g for 10 min to prepare a cell extract. 2. The extract was fractionated in a single-step procedure by isopycnic centrifugation on a continuous sucrose or sorbitol density gradient with the Beaufay automatic zonal rotor. 3. The subcellular organelles were located in the density gradient by assay of marker enzymes and previously unassigned enzymes were localized to particular organelles. 4. The following organelles were characterized by their modal equilibrium densities in sucrose density gradients: brush borders (1.21), peroxisomes (1.18), mitochondria (1.16), endoplasmic reticulum (1.16), basal-lateral membranes (1.12). At least three distinct populations of lysosomes with different modal densities and enzyme content were demonstrated. 5. This analytical fraction technique can be used to study the subcellular pathology of human jejunum.


Regulation of breathing during exercise in normal subjects and in chronic lung disease. 1. The breathing pattern in normal subjects during exercise was compared with that in patients with obstructive and restrictive lung defects. 2. In most normal women and patients with obstructive or restrictive lung disease, as the frequency of breathing increased both inspiratory and expiratory duration fell. However, in most normal men (74 per cent) inspiratory duration did not fall as ventilation increased. 3. Women breathed faster than men, and both obstructed and restricted patients breathed faster than normal subjects. 4. The airflow patterns in normal men and women were similar, but most patients with restrictive or obstructive lung disease showed an approximately exponential fall in flow during expiration.


Distribution of blood flow in the hypothermic (27 degrees C) dog kidney. 1. Renal function was measured in seven normo thermic (38 degrees C) and seven hypothermic (27 degrees C) dogs. 2. The glomerular filtration rate was 60 per cent lower in the hypothermic animals, and the renal blood flow as 51 per cent lower. The intrarenal distribution of blood flow was measured by the uptake of 86Rb from the blood into different regions of the kidney. Hypothermia reduced flow by 34 per cent in the outer cortex, 72 per cent in the inner cortex, 61 per cent in the outer medulla and 69 per cent in the inner medulla. 3. Radioautography indicated a high blood flow to an area of the outer medulla of hypothermic kidneys, which may indicate medullary blood flow "shunting". 4. The results have been discussed in relation to a number of clinical and experimental observations.


Influence of severe potassium depletion and subsequent repletion with potassium on muscle electrolytes, metabolites and amino acids in man. 1. Two women with severe hypokalaemic alkalosis were investigated by means of muscle biopsy before and at the end of 2 and 3 weeks respectively of intense therapy with potassium chloride. 2. The muscle biopsy material was analysed for water, electrolytes, adenine nucleotides, phosphocreatine, free creatine, pyruvate, lactate, glycogen and free amino acids. The extra- and intra-cellular distribution of water, electrolytes and amino acids was calculated by the chloride method. 3. Both patients showed a marked loss of intracellular potassium and an increase in intracellular sodium concentration. The muscle magnesium content was also slightly decreased. After repletion with potassium chloride, muscle sodium and potassium became normal. 4. The contents of creatine phosphate, ATP, ADP, AMP, lactate and pyruvate were within normal limits, but the phosphocreatine/total creatine ratio was reduced. After repletion, a small change in the apparent creatine-phosphokinase equilibrium had occurred, suggesting a minor increase in intracellular pH. 5. The concentrations of the basic amino acids, lysine, arginine and ornithine were increased far above normal. The intracellular accumulation of arginine was much higher than the increase in lysine concentration and histidine concentration was normal. This differs from findings in potassium-depleted rats, where the intracellular lysine concentration is much higher than arginine concentration and histidine is high as well. After potassium repletion the intracellular concentration of ornithine, lysine and arginine became normal in one case and decreased considerable in the other. An increased intracellular concentration of glutamate and glutamine was also observed after potassium repletion.


A competitive protein-binding assay for 25-hydroxyvitamin D. 1. We describe a modified competive protein-binding assay for 25-hydroxyvitamin D, which does not require the prior separation of vitamin D from 25-hydroxyvitamin D. 2. Bovine albumin was used in the buffer, at a concentration of 1mg/ml, as a protein stabilizer and lipid solubilizer. Bovine albumin from different manufactures produced very different non-specific binding of 25-(3H)hydroxycholecalciferol (ranging from 3.3 per cent to 58.9 per cent). 3. The mean concentration of 25-hydroxyvitamin D in sera from normal children in Johannesburg was 76.75 +/- 24.75 mumol/ml (30.7 +/- 9.9 ng/ml).


The role of small intestine and kidney in bromosulphthalein conjugation. 1. The roles of the kidney and the small intestine in the conjugation of bromosulphthalein have been compared with that of the liver. 2. Studies with homogenates indicated that the liver has a higher bromosulphthalein-glutathione-conjugating activity than the intestine and kidney. The reduced glutathione content of the liver is greater than that of the small intestine and kidneys, which contain comparable amounts. 3. Experiments in vitro with tissue slices confirmed that the three organ are able to extract significant amount of bromosulphthalein. In carbon tetrachloride-induced hepatic necrosis the uptake and conjugation of the dye by the liver were reduced but were increased in the kidney and unchanged in the small intestine. 4. After an intravenous injection of bromosulphthalein, the percentages conjugated in the liver, kidney and gut were similar.


Self-paced walking as a method for exercise testing in elderly and young men. 1. An exercise test has been developed which is suitable for elderly or frail subjects. It is based on free walking at three different speeds on a level indoor course of 256m. The subject sets his own pace in accord with simple instructions. 2. Twenty-four elderly men and ten young men took part in the study. 3. The time and number of paces taken to cover two sections of 100m within the course were used to establish that the subjects walked steadily. Walking speed, pace frequency and stride length were then calculated. 4. Heart rate was obtained with body-borne tape recorders and related to the walking speed. The heart rate at a standard walking speed could then be obtained by interpolation. This is an assessment of the cardiovascular response to exercise (physical condition). The variation on repeating the test was +/-5 per cent and there was no significant difference between the two age groups. 5. The assessment was found to correlate moderately well with a conventional assessment of physical condition based on oxygen uptake from tests on a bicycle ergometer. 6. The test could also be used as a performance index since walking speed was characteristic for the subject. The younger group walked significantly faster than the older group. As a performance index the test is therefor sensitive to age differences.


Peritonsillar abscess caused by a large tonsillolith.


Good will.

Good will.


Care of the elderly patient.

Care of the elderly patient.


Effective interpersonal skills.

Effective interpersonal skills.


Are you getting the most from your full-service dental supplier?


Caries-preventive technics show impressive results.


Oral lesions. An American Dental Assistants Association continuing education course.


Group practice, pro and con: 25 years in retrospect.


Drug therapy in dentistry: advances and Rx guidelines.


Will dentistry eventually make use of expanded duties and denturism?


New finger-control device for handpiece operation.


Bicentennial operatory marks spirit of '76.


Labial alveoloplasty for maxillary protrusion.


Co-operative efforts bring bonus for children's health camp clinic.


How insurance carriers should look at preventive dentistry.


Membrane remodeling during phagocytosis in chronic myelogenous leukemia cells.


Erythroid cell differentiation.

Erythroid cell differentiation. We have reviewed erythroid cell differentiation from two points of view: 1) differences between fetal and adult human red cells with particular reference to alterations which can occur in the normal pattern of erythroid cell development during the course of leukemia; 2) beochemical events which occur during erythroid cell maturation, as a model system for the study of the control of gene expression. During the course of many leukemias there is the synthesis of red cells containing fetal hemoglobin. In most cases this phenomenon is limited to a small population or clone of red cells and probably represents a nonspecific response of the bone marrow to a hematologic stress. However, in juvenile chronic myeloid leukemia and, in rare cases of erythroleukemia, there is a major reversion to fetal erythropoiesis, with progressive increase in fetal hemoglobin levels and synthesis of red cells which contain not only fetal hemoglobin but have a true fetal pattern of protein synthesis affecting proteins other than Hb F, namely Hb A2, carbonic anhydrase and the membrane antigens i and I. In this case, the fetal erythropoiesis may be a more specific manifestation of the leukemic process and may be related to the phenomenon of fetal protein synthesis (alpha-fetoprotein of carcinoembryonic antigen) observed in other types of neoplasia. Further information on the etiology and pathogenesis of abnormal cell proliferation and differentiation in the leukemias can be obtained by the study of experimental systems permitting the investigation of the regulation of gene expression in differentiating mammalian cells. Maturing erythroid cells provide a promising system for such investigations for many reasons: differentiating erythroid cells can be obtained relatively free of other cell types; a large amount of a well characterized product, hemoglobin, is synthesized; techniques are now available that permit isolation of erythroid precursors at different stages of differentiation (5-8); and finally, highly sensitive methods of measuring globin mRNA levels by DNA-RNA hybridization are currently available (13, 26, 27). We have used such techniques to measure levels of globin mRNA in separated populations of murine erythroid cells at different stages of maturation. These studies demonstrated a correlation between globin mRNA content and degree of morphological maturation. In the least well differentiated cells, however, there appeared to be a disproportionate amount of mRNA for the level of hemoglobin synthesis in these cells. These results suggest the presence of some translational control of globin mRNA in the early stages of erythroid development, although the major control of globin gene expression in this system seems to be at the transcriptional level...


Molecular mechanisms in erythroid differentiation.


Trends in the treatment of childhood leukemia.


Aids in the management of leukemia (cellremoval by continuous flow leukapheresis and impulsecytophotometry).


Terminal deoxynucleotidyl transferase in normal and neoplastic hematopoietic cells.


Proliferative behavior of hemopoietic cells in preleukemia and overt leukemia observed in one patient. Hemopoietic cell proliferation was studied in a patient suffering from preleukemia characterized by peripheral pancytopenia and hypercellular bone marrow with ineffective erythropoiesis. Two years later when overt acute myelogenous leukemia had developed the study was repeated. The kinetics of proliferation were investigated by a new method which allows evaluation of the rate and time of DNA synthesis in individual morphologically defined cells. Erythropoiesis was found ineffective to the same degree in both stages of disease. The rate of erythroid cell proliferation, however, was reduced in overt leukemia only. The myeloid system showed a grossly reduced production rate of myeloblasts in preleukemia whilst the same parameter was strongly increased in leukemia. This high production rate of myeloblasts in overt leukemia was interpreted as indication of a far-reaching self-maintenance of the myeloblast pool in this stage of disease. The proliferative activity of the individual myeloblasts was reduced already in preleukemia, and even more so in leukemia. In order to explain the amplification of the myeloblast pool with the onset of overt leukemia a change in the mode of myeloblast divisions is assumed. For this a transition from steady state to some degree of exponential growth gives the most plausible explanation.


Leukemic anaplasias reflecting physiologic cytogenesis of myeloid system. Naphthol AS-D chloroacetatesterase activity in peripheral blood granulocytes is confined to neutrophils which are all positive and to a minor part of monocytes. Its occurance in eosinophils  and basophils indicate a myeloproliferative disease. This chemical property can reliably be applied to separate neoplastic from reactive forms of quantitative and qualitative leukocyte alterations. The developmental line of this specific myeloid cellular attribut has been presented to elucidate its diagnostic significance and its validity as proof for existence of a common promyelocyte from which neutrophils, monocytes, basophils and eosinophils originate.


Immunological follow-up of acute lymphoblastic leukaemia. In different treatment groups of children with acute lymphatic leukaemia and undifferentiated leukaemia, the lymphocyte count and a number of immunologic parameters were examined during the various stages of treatment. These parameters were related to the type of chemotherapy as well as the stages of treatment. This paper deals with the values of lymphocyte counts, of gamma globulin, IgG, IgM and IgA and the results of the DNCB skin tests, as a parameter for cellular immunity. IgG determined by acetate sheet electrophoresis showed no significnat change, while its significant reduction was shown during the periods of prophylactic reinduction with vincristine in the Pinkel VII scheme, The IgM level was significantly raised in the initial stage before treatment and in all periods of treatment both in the Pinkel VII group and in an earlier therapeutic group treated with methotrexate every two weeks and vincristine pulses every six weeks. IgA was raised in both groups before treatment but significantly reduced during the phases of maintenance and reinduction. About 50% of the P VII cases had negative DNCB skin tests during maintenance therapy, while all long-term survivors in the earlier methotrexate group had a positive skin test.


The effect of immunotherapy on survival of patients with acute myelogenous leukaemia after relapse. A randomized controlled clinical trial for the use of immunotherapy for maintaining patients with acute myelogenous leukaemia has been conducted involving 52 patients. All patients received short pulsed maintenance chemotherapy but 30 of the patients received additional immunotherapy consisting of BCG and irradiated allogeneic myeloblastic leukaemia cells. Of the 22 patients who received chemotherapy alone, 19 died with a medium survival of 39 weeks, whereas 20 of the 30 patients who received chemotherapy plus immunotherapy died with an estimated median survival of 74 weeks. The value for the significance of the difference in death rates of patients was less than .01. The main effect of this immunotherapy was, however, due to a prolongation of survival after the patients had relapsed; the median survival for the immunotherapy patients being 23 weeks compared with only 11 weeks for the chemotherapy alone patients (p less than .005). The overall results also show that there was a slight prolongation of first remission in patients who received immunotherapy with a median duration of 44 weeks compared with 27 weeks for patients who received only chemotherapy. The possible mechanisms of action of this form of immunotherapy are discussed.


Translation level control in normal and leukemic cells.


Therapeutic results: report of the Hungarian children's leukaemia study group. In Hungary, the morbidity of leukaemia in children aged 0 to 15 years is 3.6/100,000. The rate of complete remission was 88.5% in ALL and 57.1% in AML. The most important factors limiting survival were infections acquired during induction therapy in 91.3% and during Co irradiation in 66.3% of the patients.


Treatment of acute lymphoblastic leukaemia. In acute lymphoblastic leukaemia the combination prednisone-vincristine induces more than 85% complete remissions. L-asparaginase which was used in complete remissions, seemed to increase their duration. Actually the best maintenance treatment consists in the combination of 6-mercaptopurine and methotrexate interrupted by reinductions. In other respects C.N.S. prophylaxis with intrathecal methotrexate and craniospinal irradiation is necessary. The well-known prognostic factors are: age, leucocytosis, tumoral syndrome, and cytological type: 216 cases of long remission have been observed. One group of these patients was treated by old methods: this represents 0.8 to 1% of the material, while 20% were treated by recent protocols with reinductions (20%).


Hypercalcaemia in leukaemia.

Hypercalcaemia in leukaemia.


Comparative observations in the treatment of acute leukaemia. The results of treatment of 84 acute leukaemia patients during a 15-year period are reported. Sixty-three of the patients suffered from acute myeloid leukaemia, 14 had blastic crisis of chronic leukaemia and 7 had acute myelomonocytic leukaemia. Administration of prednisolone + purinethol, prednisolone + vincristine, and prednisolone + vincristine + purinethol combinations resulted in partial remission. The best results were achieved with the combination ARA-C + thioguanine + prednisolone, which produced complete remission in 2 out of 8 cases. One patient was refractory to this treatment.


Remarkable growth of dentistry-related research activities at the University of Iowa.


Nitinol wires: Serendipity and research.


Mobile dental unit: Community dental experience.


Combination chemotherapy in adults with acute leukaemia. Ten patients with ALL and 35 with AML received combination chemotherapy at out Institute during the period 1972 - 1975. Patients with ALL were treated according to the L-2 protocol, those with AML according to the L-2, MRC 5/A, MRC 5/B and TRAP protocols. Nine of the 10 patients with ALL entered complete remission, and median survival time of these patients was 9.2 months. Four of the 35 patients with AML achieved complete, 13 partial remission. Median survival in this group was 4 months. Infection and bleeding represented the most frequent and severe forms of complication. Bleeding was well controlled by the administration of platelet concentrates, but infections were often lethal. The poor results were probably due to the high incidence of severe infections.


Proliferation kinetics of granulocyte precursors in the bone-marrow of normal and chronic myeloid leukaemia patients.


Management of Iowa's largest group practice: Individual service through automation.


Give plaque the brush.

Give plaque the brush.


Helpful services of the health sciences library.


Capitation aid in the health manpower act.


From the Dean's desk.

From the Dean's desk.


Biochemistry and dentistry at Iowa--1976.


Viewpoint: competence, communication, and culture-continued.


Enzyme polymorphism in feral, outbred and inbred rats (Rattus norvegicus). Polymorphism at 25 loci coding for liver enzymes was studied in two feral, three outbred and three inbred rat strains by starch gel electrophoresis. No variation was found at 14 loci, and a low degree of polymorphism was detected at three. Eight loci were polymorphic in more than one population. The average degree of heterozygosity per locus per individual feral rat was 0-07. The degrees of heterozygosity observed in the outbred and inbred strains were lower, from 0-006 to 0-012. Contrary to expectation, the inbred strains were neither monomorphic nor appreciably less heterozygous than the outbred ones. The heterozygosity of the inbred strains was primarily due to two polymorphic loci, G-3-pdh and alpha-Gpdh. The reason for this polymorphism is probably the superior homeostasis of the heterozygotes.


Ribosomal DNA content and bobbed phenotype in Drosophila hydei. The number of ribosomal RNA genes in different Drosophila hydei stocks has been determined by filter saturation hybridisation experiments. It has been shown that there is no marked correlation between the average rRNA gene number per cell in the whole animal and the bobbed phenotype when Y chromosomal nucleolar organisers are present.


Unique multiple sex chromosomes of the tree mouse Vandeleuria o. oleracea: identification of X1 and X2. The tree mouse Vandeleuria o. oleracea has an odd diploid chromosome complement (2n = 29 female/male) accompanied by a unique multiple sex-chromosome mechanism (X1X2Ymale/X1X1X2female). In the present paper the sex chromosomes have been identified unequivocally with the help of G-banding and DNA replication patterns which confirm our earlier suggestion that the X1 is smaller in size than the simple mammalian X, and also that the combined sizes of the X1 and X2 (3-8 and 1-7 per cent respectively) approximate to the size of the conservative mammalian X (5 per cent). It is proposed that the mammalian X has attained a minimum functional size so that further reduction is not tolerated.


Variation in a natural population of Schizophyllum commune. Variation within the extreme isolates for growth rate. Two extreme dikaryotic idolates chosen from a large sample of a localised population of Schizophyllum commune exhibited a considerable amount of genetical variation for growth rate at the near ambient temperature of 20 degrees C and at the higher temperature of 30 degrees C. The potential variation within these extreme isolates were greater than the variation observed in the whole sample. Regression analysis of the variation in growth rate of the dikaryotic progeny of the extreme isolates on that of their component monokaryons showed that the nature of gene action was not the same in these two stages of the life cycle. The simple additive-dominance model of gene action was adequate to explain the variation in growth rate in both of the extreme isolates at both of the temperatures. The small deviations from this model could be accounted for by unequal gene frequencies due to small sample size although a low incidence of non-allelic interactions could not be rule out. Directional dominance for growth rate was detected in both isolates at the more normal temperature and it was opposing in direction in the two isolates. In the slow growing isolate the dominance was for faster growth and in the fast growing isolate it was for slower growth. This is expected for a character which displays overall ambi-directional dominance if isolates with more extreme growth rates than those recovered in the population sample are eliminated by stabilising selection. The dominance is temperature dependent being ambi-directional in both isolates at the higher temperature. Environmental heterogeneity, the buffering effects of directional dominance and genotype-environment interactions and opposing selective forces operating on the monokaryotic and dikaryotic stages of the life cycle are possible contributory factors to the considerable free and potential variability displayed in this small, localised population.


Affinity chromatographic purification of human lysozyme, with special reference to human leukemia lysozyme. Lysozyme [EC 3.2.1.17] was purified from human tears, serum, and urine of acute monocytic leukemia patients, renal disease patients, and residents in cadmium-polluted areas of Tsushima Island using an affinity adsorbent containing lysozyme-lysate of Micrococcus lysodeikticus cell walls as the ligand. By means of this procedure, leukemia lysozyme was purified 100- to 200-fold with an activity recovery of 80%. It was crystallized at pH 10. This purified preparation appeared homogeneous in disc electrophoresis and showed a specific activity 2.5-fold higher than that of crystalline lysozyme from hen egg-white. Tear lysozyme was also purified to a nearly homogeneous state while the enzymes from normal serum and urine of a nephrosis patient and of residents in cadmium-polluted area were still disc electrophoretically heterogeneous and showed low specific activity as compared with purified leukemia lysozyme.


Homotransplantation of human teeth with and without pulp tissue.


"Implantology"--the psychological barrier.


Evaluation of dental implants.

Evaluation of dental implants.


Patient motivation in oral implantology.


Dear Editor:.

Dear Editor:.


Dental implants.

Dental implants.


The anatomy of the external palpebral ligament in man. The correct anatomy of the external palpebral ligament is demonstrated, based on microscopic studies. An analogy to the structures of the internal palpebral ligament is found.


Traumatology of the maxillo-facial region in childhood: (statistical evaluation of 210 cases in the last 13 years). A statistical study of fractures occurring in children with injuries of the head neck admitted to the clinic for Maxillo-Facial and Plastic Surgery of the Face, Düsseldorf, during the past 13 years is presented. The 210 cases were evaluated according to age, sex, frequency of occurrence, type, localisation and cause of injury, as well as therapy and average duration of treatment.


Staff relationships and communications in the dental office.


Multiple and total mandibular alveolar osteotomy. Surgical movement of teeth by alveolar osteotomy is described as a method of restoring occlusion. The use and advantages of metal "cap" splints is considered in the treatment of multiple and total segmental osteotomies of the mandibular alveolus.


A variation in the vertical osteotomy of the rami for correction of retrognathism: preliminary report. A new method for the surgical correction of mandibular retrognathism is proposed. With this method, the ascending ramus is osteotomized vertically from an extra-oral incision. The condylar segment is then inserted in a step, which has been cut in the mandibular segment, so that the mandible is fixed in its new advanced position. This step-like support of the segments obviates the tendency to relapse. This surgical procedure is a modification of the technique for vertical osteotomy of the ascending ramus described by Robinson (1957) for the correction of retrognathism.


Transosseous wiring in the treatment of condylar fractures of the mandible. During 1973-1975, 27 patients with condylar fractures at the lower or middle level were operated on via the submandibular approach; 5 patients were under 14 years of age. The condyles were medially dislocated or severely displaced, leading to malocclusion. Various kinds of transosseous wirings were used and the mean time of intermaxillary fixation was 22.6 days. The follow-up study of the 27 patients was made on average 11.6 months after the operation. Postoperatively the mouth opening averaged 41.5 mm. There was a slight deviation of the chin (mean 2mm) to the operated side in half the cases. Lateral excursions were within normal limits. Slight motor weakness in the lower lip on the operated side was noted in 3 cases and mild pain in the operated joint in 8 cases. A radiograph revealed some shortening of the condyle in most cases, and some kind of angulation, mostly posterior, in half the cases. No tendency to ankylosis was found and totally normal and symmetric function of the joints was noted in 24 cases. In the light of the results of this follow-up study the method presented, which is not a very easy one, seems to be useful.


The bucket-handle flap for closing fistulae around the premaxilla. A hithero unpublished vestibular flap for closure of oro-nasal fistulae in cleft patients is reported. 5 cases have been operated on with this technique so far. The surgical technique as well as possible complications and disadvantages are described.


Animation of facial palsy in Moebius syndrome by means of a circumoral sling: case report. The case of a 3-year-old female is reported whose condition was diagnosed as congenital, complete paralysis of the right facial nerve in 1962; and a short time later more specifically described as Moebius syndrome. In 1971, a circumoral fascial sling was inserted in preparation for a masseter muscle transfer. Voluntary movement on the right side of her mouth was noted following surgery and continued to improve, making facial actions more symmetrical. This function has remained stable during a five year follow-up. Although the mechanism of action is not fully understood, it is postulated that the presence of the sling may have presented the subclinically active muscles a force to work against or perhaps the surgery may have liberated those muscles from adjacent fibrous tissue.


You are hereby summoned to appear!

You are hereby summoned to appear!


Trismus resulting from central nervous system lesion. Three cases of unusual trismus are reported, occurring in patients with lesions of the central nervous system. On the basis of the clinical and electromyographical findings and observation of the course of the trismus this is interpreted as a symptom of a lesion of the brain stem, causing a dis-synergism of the masticatory muscles.


Leadership excellence...something old, something new.


Clinical classification and staging in oral cancer. The literature regarding TNM-classification and staging as applied to oral cancer is reviewed and the shortcomings of the various systems are discussed. A new system for the classification and staging of carcinomata of the oral cavity is described. This system includes recording the site of the lesion (S) and the pathology (P) in addition to the conventional TNM criteria. The new system for staging involves the summation of arithmetic discriminants attached to each of the variables S, T, N, M and P. This system is more simple to use and is able to predict a more accurate prognosis for the patient.


Desmoplastic fibroma of the mandible: case report. This report describes the case of a 2-year-old girl with desmoplastic fibroma of the mandible, with swelling in the region of the mandibular angle which had been wrongly diagnosed several times. A biopsy was interpreted as showing a low-grade fibrosarcoma. The patient then received treatment with cytotoxic drugs, and later a mandibular hemi-resection was performed. The postoperative diagnosis was Jaffé's desmoplastic fibroma (non-osteogenic). The age of the patient, the rapid development of the tumour and the accompanying pain suggested a sarcoma, and the first pathological examination seemed to provide confirmation. The post-operative course was very favorable, and the patient is considered to clinically cured, after one year.


Angiolipoma of the hard palate: a case report and review of the literature. A case of a large angiolipoma of the hard palate is presented. This constitutes a new site for this type of tumour.


Bilateral aplasia of the nose: a case report. After presenting a case of bilateral agenesis of the nose, and description of normal morphogenesis of the face, an explanation for the malformation is sought. The comparison of non-existent, rudimentarily preformed and existing elements with normal facial morphogenesis leads to the assumption of an incomplete formation of the frontal process, which has led to a hypoplasia of the secondary processes (nasal processes). The reason is advanced for abandoning the construction of a functioning nose and the reconstruction of the external nose is described.


TNM-classification of carcinomas of the oral cavity-efficacy of clinically available data (TN). Using adequate number of cases, the influence of the spread of primary tumour and the degree of regional metastasis on prognosis were investigated. Assuming a practicable classification as a prerequisite for clinico-therapeutic cancer research, experience has shown that the assessment of the spread of primary tumour alone does not suffice for the establishment of comparable homogenous data. The investigation on the importance of the degree of regional metastasis has shown, above all, that the percentage of N3-metastasis within the T-groups contributes essentially to the fact that these show a marked difference in their prognosis. It would therefore appear necessary also to examine the importance of other clinically accessible data in the assessment of prognosis. Only then could we be in a position to judge whether, and to what extent a clinically practicable classification and integration into special groups is possible on the basis of clinically available data. The inclusion of more clinics in the joint investigation is encouraged.


Thromboelastographic changes in carcinoma: an animal model. The dynamics of blood clotting using a thrombelastogram (TEG) are depicted after the injection of V2 carcinoma cells or control heterologous peritoneal exudates in New Zealand hares. Changes in the TEG configurations of native blood samples vs. celite activated samples run simultaneously provide a qualitative assessment of the presence of carcinoma.


The psychology of nitrous oxide.

The psychology of nitrous oxide.


Adenosine aminohydrolase from human spleen: partial purification and some kinetic properties. Adenosine aminohydrolase from human spleen was purified 120 fold. In pH 7.3 phosphate buffer at 37 degrees, this enzyme preparation deaminated adenosine and arabinosyladenine (ara-A) with apparent values for the Michaelis constant of 40 muM and 90 muM respectively. The products of both deamination reactions, i.e., inosine and arabinosylhypoxanthine, were competitive inhibitors with Ki equal to 710 muM and 60 muM, respectively. N6-benzyladenosine and 2'-deoxy-N6-benzyladenosine were competitive inhibitors. The former was better able to inhibit ara-A than adenosine deamination, while the latter was equivalent in inhibiting deamination of these two substrates. Evidence for a naturally occurring adenosine aminohydrolase inhibitor in spleen was presented. It is suggested that benzyladenosine and deoxybenzyladenosine might potentiate ara-A chemotherapy of neoplasms and metastates in the spleen and other hemic cells.


Protective effect of allopurinol on bronchiolar constriction induced by histamine. In order to examine the protective effect of allopurinol on experimental asthma produced by histamine aerosol in guinea pigs, allopurinol was administered intraperitoneally resulting in a significant prolongation of survival times. Significant elevation of blood ATP levels was shown in guinea pigs pretreated with allopurinol compared to the control guinea pigs. It is thought that this beneficial effect prevents the loss of functional purine base.


Thymidine and uridine degradation by nucleosidases of cultured human lymphoblastoid cells. Cultured human lymphoblastoid cells of different lines elaborate rapidly pyrimidine-specific nucleosides when incubated as a dense population in a serum-containing milieu. No appreciable changes in viability or morphology were detected in the time required for maximal enzyme production. These nucleosidases degraded thymidine, uridine and cytidine; adenosine and guanosine were not catabolized. Cell viability and proliferation were not affected by these heat-labile and ultraviolet-sensitive enzymes. Products arising from nucleosidase degradation of radiolabeled pyrimidines, which were separated and identified by paper chromatography, were not incorporated by DNA- and RNA-synthesizing lymphoid or nonlymphoid cells.


Diuretics in malignant effusions and edemas of generalized cancer. Forty patients with generalized cancer complicated by water and electrolyte retention were treated with "medium" and "large" doses of furosemide and bumetanide with 35% and 40% objective positive response, respectively. A smaller percentage of patients benefited from these diuretics, mainly in the quality of their lives. Peaks" of diuresis lasting a few days were observed in positive diuretic response. It is therefore concluded that diuretics may be more effective in malignant conditions if administered in a "high-dose pulse" therapeutic schedule.


Bioenergetics in clinical medicine. XI. Studies on coenzyme Q and diabetes mellitus. The activity of the succinate dehydrogenase-coenzyme Q10 reductase from 120 diabetic patients was significantly lower (P less than 0.001) and the per cent deficiency was significantly higher (P less than 0.001) than that of the controls. The diabetes of 37 patients was controlled by diet; the enzyme activity was lower (P less than 0.001) and the deficiency was higher (P less than 0.02) than for controls. In decreasing effectiveness, Dymelor, Glyburide, Phenformin and Tolazamide inhibited the COQ10-enzyme, NADH-oxidase. Tolbutamide, Glypizide, and Chlorpropamide were noninhibitory to succinoxidase and NADH-oxidase. Patients receiving Tolazamide and Phenformin showed a higher incidence (P less than 0.001 to P less than 0.05) of COQ10-deficiency than patients controlled by diet or normal controls. Certain diabetic patients controlled by diet may have a deficiency of COQ10 which may be enhanced by the inhibition by certain commonly used antidiabetic drugs of COQ10-enzymes. A deficiency of COQ10 in the pancreas could impair bioenergetics, the generation of ATP, and the biosynthesis of insulin.


Regulation of resistance to various toxicants by PCN (pregnenolone-16alpha-carbonitrile) and thyroxine. In rats, PCN (the most potent catatoxic steroid known to date) at the usual dose level powerfully inhibited the toxicity of antazoline, carbamazepine, cocaine, guanethidine, ibuprofen, ketamine, LSD, nembutal and reserpine, whereas (except in the case of nembutal) thyroxine sensitized the animals to intoxication with these same compounds. Even much lower doses of PCN or thyroxine exerted similar but weaker effects. PCN-induced resistance to the various substrates was generally not altered by concurrent administration of thyroxine but in a few cases its protective action was partially or totally inhibited, depending upon the respective dose levels of both compounds.


The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia. A single dose of cis-dichloro(dipyridine)platinum(II) (cis-PPC), when given to BDF1 mice bearing 1-day-old L1210 leukemia, suppressed the increase of spleen and liver ornithine decarboxylase (ODC) activity which occurs concomitantly with development of the leukemia. The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. These observations suggest an additional mechanism by which platinum complexes express their antitumor actions and, in addition, support the view that polyamine synthesis and excretion patterns can be used as predictors of chemotherapeutic response.


Three hour hemodialysis with double coil dialyzer. Blood urea nitrogen and weight reduction can be accomplished in renal failure by doubling the surface area of the standard dialysis coils. This results in a reduction of time on the machine, drugs and personnel utilization.


A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report.


Transient left posterior hemiblock--report of 2 cases.


Syngeneic tumor immunity induction in Swiss mice by Abrus agglutinin treated S-180 sarcoma cells.


What is your diagnosis?

What is your diagnosis?


Who owns x-rays?

Who owns x-rays?


The mandibular staple fastener system, a new modality in preprosthetic surgery.


Continuing education: a voluntary program.


President's message.

President's message.


The dentist shortage.

The dentist shortage.


106 paychecks.

106 paychecks.


Perspectice.

Perspectice.


Anatomical aspects of implantation.

Anatomical aspects of implantation. Although there is a fascinating variety of morphological relationships at different stages of implantation in various species, some common patterns can be discerned. The position within the uterus where blastocysts are found after transport is the end result of the activity of the uterine musculature, the endometrical conformation, and the size and shape of the blastocyst. Blastocysts of some species are situated in the approximate position where they will implant for an appreciable period of time. Apposition, brought about by blastocyst swelling or uterine lumincal closure, is the necessary prerequisite for the initiation of adhesion. Adhesion per se is progressive and involves the surface coats of the trophoblast and uterine luminal epithelial cells. It maybe thought to include such events as the development of adhesive factor(s) on the trophoblast and the local deletion of some of the uterine coat constituents. When adhesion is followed by invasion of the uterine mucosa, the trophoblast adheres closely to the uterine epithelial cells, sharing junctional complexes with healthy cells, and engulfing displaced or surrounded cells.


Longitudinal perspectives on sorbents in uremia.


Microcapsule artificial kidney: including updated preparative procedures and properties.


Artificial support systems for liver failure.


Treatment of hepatic coma with hemoperfusion through polyacrylamide hydrogel-coated charcoal.


Improved hemoperfusion systems for renal-hepatic support.


Intestinal dialysis in 1975 perspective: sorbents and intestinal loop nitrogen transport.


Effect of microencapsulation on competitive adsorption in intestinal fluids.


In vitro reactivity of oxystarch and oxycellulose.


Projections and measurements of in vivo performance of liquid membrane capsules.


Further studies with oxystarch.

Further studies with oxystarch.


Clinical use of oxystarch.

Clinical use of oxystarch.


Combined oxystarch-charcoal trial in uremia: sorbent-induced reduction in serum cholesterol.


A cold charcoal depurator for the adsorption of high quantities of urea.


Dialysate regeneration: 30-liter dialysate supply system with sorbents.


Sorbent regeneration of dialysate.

Sorbent regeneration of dialysate.


Towards a wearable artificial kidney.

Towards a wearable artificial kidney.


The charcoal-coil: a dialysis-dialysate regeneration system.


Hemoperfusion alone and in series with ultrafiltration or dialysis for uremia, poisoning and liver failure.


Hemocarboperfusion-hemodialysis treatment in terminal renal failure.


Evaluation and selection of activated carbon for hemoperfusion.


Short-term evaluation of charcoal hemoperfusion combined with dialysis in uremic patients.


Fixed-bed charcoal hemoperfusion for the treatment of drug overdose.


The rationale for fixed-bed charcoal in hemoperfusion.


Experience with hemoperfusion in drug abuse.


Hemoperfusion for acute drug intoxication.


Mechanism of life prolongation in nephrectomized rats treated with oxidized starch and charcoal.


Expectations for sorbents in uremia.

Expectations for sorbents in uremia.


Oxycelluloses: a group of sorbents to remove extracorporeal urea.


Third-party involvement in dental care.

Third-party involvement in dental care.


Dental attitudes in a rural Maori population.


The use of expanded-duty dental auxiliaries.


The choice of dentistry as a career.

The choice of dentistry as a career.


The pinledge restoration as a bridge retainer.


Speaking ex tripode.

Speaking ex tripode.


Developmental defects of enamel in New Zealand children.


Observations on submerged primary molar teeth.


A clinical evaluation of the Gow-Gates mandibular block technique.


Sensitivity of 941 beta haemolytic streptococci to antibacterial drugs. Nine hundred and forty-one strains of beta haemolytic streptococci were Lancefield grouped and their antibiotic sensitivities tested by the agar plate diluting technique to penicillin, erythromycin, lincomycin, tetracycline and sulphafurazole. All the strains tested were sensitive to two units per ml or less of penicillin. This MIC is higher than that reported in other surveys and indicates increasing resistance of these organisms to penicillin. All the strains tested were sensitive to two mug/ml or less of erythromycin. Fifty percent of all strains were resistant to tetracycline and sulphafurazole.


Rheumatic fever in New Zealand: the Waiora College survey design and response rate. The outline organisation of a health survey of a secondary school is presented. The aims of the survey were primarilary to provide population data on rheumatic fever in a high incidence area, and to further knowledge of the distribution of risk factors for coronary heart disease in New Zealand adolescents. Ninety-six and a half percent coverage of the target group was achieved; non-responders were characterised from hospital and school records as being predominantly rural with greater early childhood hospital experience than respondents. The sample was considered to be representative of the adolescent population of the area.


Survey of ophthalmic surgery in North Canterbury and Westland (1970-1975). The major ophthalmic operations performed in the Christchurch hospitals over five years are listed. This gives the incidence of ophthalmic conditions requiring surgery in a mainly European Community. The results should be useful for planners and epidemiologists in this and others countries.


Report on five and a half years of the Cancer Detection Centre, Aukland Division, Cancer Society of New Zealand. An account is given of the setting up of a cancer detection centre at Auckland. In the first five-and-a-half years 3001 patients were examined. Forty-two cancers were detected and 1056 patients had non-malignant medical diseases.


Successful bismuth (De-Nol) therapy for gastric ulcer. Fourteen patients with chronic gastric ulcer were treated with a bismuth preparation (De-Nol) on an outpatient basis. The healing rates were good as with hospital admission and better than a control group of outpatients.


One year's rheumatic fever from one general practice in Wairoa, Hawke's Bay. Sixteen cases of rheumatic fever from one general practice are described and the indication for prophylactic penicillin is discussed.


Some needs of the elderly.

Some needs of the elderly.


Paraquat poisoning.

Paraquat poisoning.


Psychiatric assignment.

Psychiatric assignment.


What about the relatives?

What about the relatives?


Looking towards the eighties.

Looking towards the eighties.


Medico-legal problems for medical and allied staff.


The role of police at deaths.

The role of police at deaths.


The care of the psychiatric patient today.


Gastroenterologist outpatients.

Gastroenterologist outpatients.


An American experience.

An American experience.


Focusing the spotlight on nursing.

Focusing the spotlight on nursing.


Nature and purpose of nursing courses.

Nature and purpose of nursing courses.


Women in the work force.

Women in the work force.


Death and dying -- specifically related to intensive care areas.


Fractured femur: a patient's viewpoint.

Fractured femur: a patient's viewpoint.


Development of veterinary public health in the veterinary curriculum at Massey University.


An equine surgery and operating table.

An equine surgery and operating table.


Diffuse mesangioproliferative glomerulonephritis in a horse.


Effects of ammonia inhalation of young cattle.


Chronic udder oedema: clinical aspects of the syndrome and its connection with hypomagnesaemia and anaemia.


The electromyographic activity of intrinsic laryngeal muscles during quiet breathing in the anaesthetized horse.


Lymphocyte alpha-mannosidase -- a supplementary test for determining mannosidosis genotype in cattle.


The effects of Leptospira serotype pomona in sheep of different haemoglobin types.


Psychrotrophic meat spoilage fungi within a freezing works.


Isolation of equine herpesviruses from horses with respiratory disease.


An obligation to lead.

An obligation to lead.


Avian reoviruses in New Zealand.

Avian reoviruses in New Zealand.


Mannosidosis -- a cause of neonatal mortality in Angus calves.


The relationship between ovarian status and oestrous behaviour in beef cows.


Zoonotic infections in veterinarians.

Zoonotic infections in veterinarians.


Deaths in cattle suggestive of subacute fluorine poisoning following ingestion of superphosphate.


Preparation of gastro-intestinal tracts for submission to the laboratory: a preservation technique.


Dexamethasone and mastitis in cows.

Dexamethasone and mastitis in cows.


Isolation of a leptospire belonging to serogroup tarassovi.


The influence of carbon content on the mechanical properties in a cast dental Co-Cr alloy. By varying the amount of acetylen in acetylene-oxygen flames Co-Cr test pieces with a varying carbon content were produced. The hardness, yield point for 0.05 per cent, 0.1 per cent and 0.2 per cent tensile strength and elongation were determined for these test-pieces. The results showed that hardness, yield points and tensile strength increased with increased carbon content, whereas the elongation lessened. The clinical importance of the altered mechanical properties due to increased carbon content in the Co-Cr alloy under study was discussed.


The effect of an occlusal interference on the masticatory system. An experimental investigation. An experimental short term study on the effect of an occlusal interference on the path of closure of the mandible was carried out on 8 persons. The interference consisted of a gold inlay placed unilaterally in one of the mandibular first molars. Clinical and electromyographic studies revealed functional disturbances or pain in all subjects. The masticatory musculature was tender to palpation and showed coordinational disturbances; the TMJ showed tenderness to palpation, clicking and irregular movements and the interfering teeth periodontal tenderness.


Motor pause frequency in the masseter muscle in relation to food texture. EMG activity was recorded from the masseter muscles of 10 naturally dentate subjects during the chewing of hazelnuts, peanuts, Optosil and chewing gum. The frequency of motor pauses (10-50 ms long) in the EMG patterns was found to be related to the textural properties of the test food. It was also found that the frequency varied for different parts of the chewing sequence, being significantly higher initially than in the last part of the chewing sequence. Motor pauses of this length, however, were absent from many of the EMG patterns. It is concluded that these motor pauses are signs of certain events during chewing but are probably not part of any basic reflex necessary for the neurophysiological regulation of chewing.


The influence of different heat treatments on a dental Co-Cr alloy. The change in microstructure and hardness in a cast Co-Cr alloy (type A) with a carbon content of 0.45% was studied both when the alloy was aged at temperatures between 600 degree C and 1200 degrees C and when it was isothermically heat-treated at temperatures between 800 degrees C and 1000 degrees C after solubility treatment at 1200 degrees C. Furthermore, studies were undertaken on how aging at 800 degrees C, solubility treatment at 1200 degrees C and isothermal heat treatment at 800 degrees C after solubility treatment at 1200 degrees C affected the mechanical properties. The results showed that both aging and isothermal heat treatment could change both microstructure and hardness. The changes in the mechanical properties by heat-treatment, however, did not improve the usefulness of the alloy in dentistry, principally because the elongation was reduced. The change in microstructure explained the change in hardness and in mechanical properties. It was interesting to note that the properties of a Co-Cr alloy were not affected by heat-treatment at temperatures below 600 degrees C. This means that addition of gold alloys, which are soldered to a base of Co-Cr, can be both homogenised and/or hardened without affecting the properties of the Co-Cr alloy.


Changes in mandibular arch size associated with orthodontic treatment.


Cervical crown margin imperfections and location of the margin relative to the gingival crest.


Prepaid dental plans.

Prepaid dental plans.


Anti-infectives.

Anti-infectives.


Studies on short-term application of drugs to Eimeria tenella in tissue culture. The anticoccidial action of 6 drugs was studied by treating cell cultures with drug for 24 h after inoculation of the cultures with sporozoites of Eimeria tenella. A monitoring technique was used to confirm that the drug was being removed. Only monensin was shown to be coccidiocidal. Amprolium, lasalocid, methyl benzoquate, nicarbazin and robenidine were coccidiostatic at their minimum effective doses. Misleading coccidiocidal effects were observed when higher concentrations of methyl benzoquate, nicarbazin or robenidene were used.


Mercury: understanding increases safety.


Local anaesthesia.

Local anaesthesia.


Dental silicate cement.

Dental silicate cement.


Prevention and dental disease.

Prevention and dental disease.


Dental plaque and its control.

Dental plaque and its control.


Security in school dental clinics.

Security in school dental clinics.


Painless dentistry and prevention.

Painless dentistry and prevention.


Campaign against "clutter".

Campaign against "clutter".


The topical application of fluoride.

The topical application of fluoride.


Pit and fissure sealants.

Pit and fissure sealants.


Maori language with Te Nēhi Tiako Niho.

Maori language with Te Nēhi Tiako Niho.


A further evaluation of fluoridation.

A further evaluation of fluoridation.


Course in advanced school dental nursing studies.


A note on methods of toothbrushing.

A note on methods of toothbrushing.


Speech. Report of a seminar. A. Introduction.


Speech. Report of a seminar. C. What is the orthodontic relationship to speech and speech defects? a. Speech and the teeth.


School dental service staffing.

School dental service staffing.


Speech. Report of a seminar. B. What is speech?


[Processing of liver scan by an electronic computer: clinical experience].


Dentists' satisfaction with the dental information service center's placement service.


The WHO classification of bone tumors.

The WHO classification of bone tumors. The WHO scheme of classification of bone tumors is based on histologic criteria. It simply lists the main types of primary bone tumors; knowledge of histogenesis or of tumor origin is implied only for certain groups of lesions. This international agreement on nomenclature and classification of bone tumors would greatly aid comparative population studies on bone tumors in different parts of the world.


Common errors made by pathologists in the diagnosis of bone tumors. The pathologist must obtain X-rays before attempting to make a diagnosis in a bone tumor. Errors are made with both benign and malignant lesions associated with calluses. Infection may stimulate a malignant bone tumor radiographically and pathologically. Secondary aneurysmal bone cyst may dominate the radiographic and pathologic findings and obscure the primary diagnosis. Osteoblastomas are becoming increasingly difficult to diagnose. The question of whether such an entity can become malignant has not been resolved. Cartilagenous tumors are often difficult to diagnose and the pathologist must not only rely on histologic findings, but in particular pay attention to the radiographic pattern which is often diagnostic. Accuracy of diagnosis in Ewing's sarcoma is essential because the treatment now can result in a cure rate of almost 40%. Certain lesions such as lymphoma or osteosarcoma can mimic this tumor. To re-emphasize the problem, the pathologist must have all the clinical information before attempting a diagnosis of a bone tumor and without the pertinent X-ray, errors are almost inevitable.


Primary malignancy, secondary malignancy and semimalignancy of bone tumors. 1. Bone tumors in contrast to tumors in soft tissue, show a wide variety of clinical behavior qualified by the expressions semimalignancy, low grade of malignancy, sarcomatous degeneration and primarily benign bone tumors and bone lesions. 2. The term semimalignancy is characterized by local invasive and destructive tumor growth with a tendency to recur locally but no hematogeneous spreading. Semimalignancy requires wide en-bloc resection of amputation. 3. The term low grade malignancy is used to describe a tumor of very slow growth and with very late metastasis. Low-grade malignancy requires resection with careful preservation of functional structures. 4. The term secondary malignancy means the sarcomatous degeneration of a primarily benign lesion or bone tumor. This transformation is enhanced by irradiation and probably by acceleration of the normal turnover of bone tissue. In Paget's disease sarcomatous degeneration is to be expected in 2 percent of cases and in fibrous dysplasia in 0.5 percent of cases. 5. Sarcomatous degeneration of bone infarcts is rare, but an increase is to be expected due to an increased frequency of bone infarcts caused by long-term treatment with cortisone. 6. Primary bone tumors and recurrences show the same structure and cytology. In a minority of cases the recurrences are less differentiated; in a very few cases the recurrences are more highly differentiated and have a better prognosis than the initial lesion.


Aspiration (puncture of needle) biopsy in bone lesions. In certain bone tumor cases bone puncture is more profitable than sample excision. Whenever necessary we are using both methods in our practice. The results of 7165 puncutre biopsies are presented. A definite diagnosis by needle biopsy could be established in 771 tumors, including 254 myelomas and 174 osteogenic sarcomas. The aspiration or needle biopsy will require some experience not only on the part of the pathologist, but also of the surgeon. The pathologist must be sufficiently familiar with the clinical and radiographic evidence before interpreting the cytologic or the histopathologic specimen.


Histochemical and electron-microscopic aspects of bone tumor diagnosis. In recent years, histochemistry and electron microscopy have been applied more and more to the investigation of bone tumors. The contributions and limitations of these methods in differential diagnosis are discussed. The levels of glycosaminoglycans in cartilaginous tumors display distinct differences between slow- and fast-growing types. All cartilaginous tumors are poor in phosphatase activity. Demonstration of these enzymes at acid and alkaline pH in bone-forming conditions reveals differences between benign and malignant tumors. Osteosarcomas display a rich activity of both phosphatases in bone-forming and in bone-free regions. Acid phosphatase may play a rôle in the breakdown of the host tissue infiltrated by the tumor. Electron microscopy of bone tumors has brought out some interesting findings. In fibrous dysplasia a particular kind of very fine fibrillar structures was observed besides the regular collagen fibrils. This may indicate retardation of collagen maturation. Cell organelles in benign and malignant bone tumors usually differ quantitatively. They resemble active fibroblasts. In bone- and in cartilage-forming tumors we observed large quantities of microfilaments in the cytoplasm. Nuclear indentations and invaginations probably indicate increased nuclear activity. The intense acid phosphatase activity demonstrated histochemically seems inconsistent with the low number of lysosomes in the cytoplasm of osteosarcoma cells, but other organelles (Golgi apparatus and vesicles) may also contain the enzyme. Virus-like particles have not been observed in human osteosarcomas up to now. Other authors have observed a correlation between the number of cell organelles and the grade of differentiation, but this was not detected in our sample of benign and malignant cartilaginous tumors. Histochemistry and electron microscopy of bone tumors are still in the early stage of material gathering. Some histochemical findings, however, can already be used as diagnostic tools.


The treatment of malignant bone tumors by conservative surgery. The indications for local radical en-bloc resection are discussed. The preoperative work-up and the aspects to be considered before surgery are detailed, and specific diseases, operations, and experences are illustrated.


Bone tumors induced by inhalation of 238PuO2 in dogs. Plutonium-238, an alpha-emitting radionuclide, is used as a heat source in thermoeleltric power generators such as have been employed on lunar expeditions of communications satellites and in cardiac pacemakers. It has an 86.4 year half-life and emits 5.5 MeV alpha particles. Beagle dogs were given single 10-30 minute exposures to 238PuO2 aerosols to study the long-term translocation of plutonium and biological effects. Dogs with a terminal body burden ranging from 7-260 muCi were euthanized due to respiratory insufficiency related to plutonium-induced pneumonitis during the first 3 years after exposure. Nine of the 11 dogs euthanized during the 4-6 year postexposure period had osteosarcomas. The terminal plutonium body burden in the tumor-bearing dogs ranged from 0.5-2.6 muCi with 30-55% of the plutonium in the skeleton. Experiments are in progress to further define the dose-effect relationship of inhaled 238PuO2 and investigate the mechanisms of plutonium-induced neoplasia.


The immune-status in patients with bone and soft-tissue sarcomas. The immunologic status of 50 sarcoma patients was established. It was possible to apply the DNCB test and the recall antigen test in most cases during the course of the illness. The PHA stimulation of the lymphocytes and their cytotoxicity on homologous sarcoma cell lines were also correlated with the course of the illness. Nonspecific tests related neither to each other nor to the development of the illness while the tumor-specific cytotoxicity test correlated closely with the course of the disease.


Federally controlled credentialing of health professionals.


Experimental induction of bone tumors by short-lived bone-seeking radionuclides. Single and repeated applications of 224Ra and single applications of 227Th to more than 600 female NMRI mice 3 - 4 weeks old, and to male NMRI mice have led to a high rate of osteosarcomas. Tumor incidence is dose-related. 227Th is more carcinogenic than 224Ra which induced the highest tumor incidence of 60% after a single injection of 5 muCi per Kg body weight or more. Repeated injections of 224Ra to female mice yielded a tumor incidence of up to 92%. Most of these osteosarcomas consist of well-differentiated bone-forming osteoplastic tissue. Half of the tumors occurred in the spine, particularly in the lumbar region. In protraction experiments, multifocal osteosarcomas have been observed. Less than 10% of the mice with osteosarcoma had developed metastases in lung, spleen, liver, and kidney. The possible mechanisms of the protraction effect are discussed.


Etiology of childhood bone cancer: epidemiologic observations. In dogs, osteosarcoma is markedly more frequent in giant breeds than in small ones. Ewing's tumor rarely occurs in species other than man. In children, both osteosarcoma dne Ewing's tumor appear to be related to the rate of bone growth. Nonradiogenic osteosarcoma occurs excessively in persons with the heritable form of retinoblastoma, and in certain malformation syndromes, some of which are known to be genetically induced. Osteosarcoma may also be of the heritable type when it is multicentric or aggregates in families. The neoplasm may occur excessively in certain families with specific cancers not involving bone. By contrast, the only evidence of a genetic influence on Ewing's tumor is its near-absence among blacks in the United States and in Africa. The only exogenous agent known to induce osteosarcoma (but not Ewing's tumor) in man is ionizing radiation in substantial doses. There is no epidemiologic evidence for the virus etiology of bone cancer in man. Despite the epidemiologic differences between osteosarcoma and Ewing's tumor, both histologic types occasionally occur in different portions of the same neoplasm.


The relationship of somatotype and selected anthropometric measures to basketball performance in highly skilled females.


Delta dental plans communication with the providing dentist.


Arousal and anxiety correlates of gymnastic performance.


Effect of methylphenidate on cardiorespiratory responses in hyperactive children.


Traditional ground stroke versus volley method of teaching beginning tennis.


Fatigue transfer in endurance performance.


A biomechanical analysis of the karate chop.


Stabilometer performance of educable mentally retarded and normal children.


Maximal oxygen uptake on a dual-drive bicycle versus a treadmill.


The effect of impermeable clothing on weight loss, heart rate, and core temperature in wrestlers.


Individual differences in heavy work endurance at 60, 70 and 84 RPM ergometer pedal speeds.


Physiological responses of men to 1, 3, and 5 day per week training programs.


Pretask speed training and movement complexity.


Anthropometric and selected motor fitness measurements of men engaged in a long-term program of physical activity.


The effects of practice distribution on the acquisition of three discrete motor skills.


A factor study of Cratty's body perception test.


Four female collegiate track athletes: an analysis of personal constructs.


Energy expenditure and VO2 max of female athletes during treadmill exercise.


State anxiety among successful and unsuccessful competitors who differ in competitive trait anxiety.


The effect of motor and sensory set on reaction time and muscle electrical activity.


Effects of different durations of physical training on cardiorespiratory function, body composition, and serum lipids.


Effect of diet and metabolic rate on open circuit calculations of VO2 and VCO2.


Relationship between grade, sex, race, and motor performance in young children.


Relationships between selected personality and motor variables in emotionally disturbed children.


Biomechanical correlates of psychological differentiation in female athletes.


The effects of augmented levels of stress on reaction time in the peripheral visual field.


Physical performance scores as a function of experimenter sex and experimenter bias.


Effects of apnea and face immersion in water on the time components of the cardiac cycle.


A comparison of discovery learning and guided instructional strategies on motor skill learning, retention, and transfer.


Relationships among children's attitudes, involvement, and proficiency in physical activities.


Correlates of sport participation among adolescent girls.


Relationship of certain physical measurements to swimming speed.


Central circulatory adaptations to physical training.


A fine-wire electromyographic investigation of the gluteus minimus and gluteus medius muscles.


Pulmonary function at rest and during exercise in uncomplicated obesity.


Fatigue effects on the timing performance of well-practiced subjects.


Delinquent tendencies and participation in an organized sports program.


A simple stabilometer modification for qualitative recordings.


The effect of air resistance on three types of football trajectories.


Representative simple reaction and movement time scores.


An investigation of the relationship between brachial pulse wave parameters and maximum oxygen uptake.


Scoring a decathlon with a portable minicomputer.


The effects of instruction and practice on the skill of throwing with the nondominant hand.


An inexpensive analyzer for measuring oxygen uptake.


Effect of rib cage or abdomen compression at iso-lung volume on breathing pattern. In anesthetized rabbits a small compression of the rib cage (RC) caused a marked increase of breathing frequency (f), a marked reduction of expiratory duration (Te), a reduction of inspiratory duration (Ti) and tidal volume (VT), while an equal decrease of lung volume produced by abdominal compression(AC) caused a smaller increase of f and no change of Ti, and a slight increase of VT. Similar results occurred when normal end-expiratory volume was maintained during compression. The phenomena disappeared after bilateral vagotomy, whereas persisted after cordotomy in T1. Similar results occurred in dogs (with the exception that VT decreased during AC), whereas in cats only RC increased f by shortening Te. RC caused a marked increase of discharge in 11 out of 19 irritant receptor fibers, whereas AC caused an increase only in 2. In most of the pulmonary stretch receptor fibers the change of activity produced by compression paralleled the lung volume change. The effects of vagal cooling on Ti, Te and the VT-Ti relationship with and without compression suggest irritant receptors as responsible for the different ventilatory pattern during RC and AC.


Comments on the new health manpower bill.


Society to consider membership bylaws changes.


A review and comparison of the psychoanalytic and sociological conceptualizations of the alcoholic marriage.


School screening for spinal deformities in Rhode Island.


Medico-legal aspects of the concept of brain death: an appraisal.


Difficulties encountered by physicians and nurses in obtaining adequate health care for themselves.


Rhode Island students applying to U.S. medical schools: a record of the past seven years.


1976 influenza immunization in R.I.

1976 influenza immunization in R.I.


Epidemic influenza and the Rhode Island fight flu program.


Hepatic injury associated with quinidine therapy.


Genetic counseling in Rhode Island.

Genetic counseling in Rhode Island.


Annual report of the chairman of the Board of Blue Shield of Rhode Island.


Remarks of the president of Blue Shield of Rhode Island.


Nursing decisions: experiences in clinical problem solving. Series 2, Number 3. Jim R.; a young man with leukemia.


The effect of proximal gastric vagotomy on ulcer healing.


The effect of porcine calcitonin upon gastric acid secretion and serum gastrin in man.


The effect of somatostatin on gastrin release and gastric secretion.


Theoretical considerations concerning gastric inhibition.


Inhibition of gastric secretion by combined secretin and CCK and combined glucagon and CCK.


Effect of vagotomy on the response of gastric myoelectrical activity to glucagon and food. The myoelectrical activity of the gastric antrum was measured in 13 patients using intraluminal suction electrodes. In 3 patients with intact vagi, intravenous injection of glucagon 5 mug/kg and 10 mug/kg resulted in periods of increased frequency of gastric slow waves and also periods of inhibition. These findings persisted after highly selective vagotomy (7 patients) and were abolished by truncal vagotomy (3 patients). In each of 4 dogs, six silver/silver chloride electrodes implanted under the serosa were used to record the myoelectrical activity of the stomach and duodenum and its response to a meal of 450 gm of meat. Coordination of bursts of spike activity superimposed on the slow waves was significantly diminished after truncal vagotomy but not after highly selective vagotomy. These results confirm that changes in myoelectrical activity after vagotomy are related to the extent of vagal denervation.


Effect of vagotomy on gastric motility.

Effect of vagotomy on gastric motility.


Effect of proximal gastric vagotomy on gastric secretion.


Inhibition of gastric secretion by intrajejunal fat. Influence of bile, pancreatic juice, and cholinergic mechanisms.


The role of antral and duodenal innervation for gastric secretion and serum gastrin concentration.


Fitting "continuous wear" soft contact lenses at the time of cataract extraction.


Clinical and immunological study of anterior uveitis in juvenile chronic polyarthritis.


Combined glaucoma-cataract surgery.

Combined glaucoma-cataract surgery.


Uveitis and optic neuritis as an expression of autoimmune disease.


Ocular sarcoidosis.

Ocular sarcoidosis.


Uveitis in tropical ophthalmology.

Uveitis in tropical ophthalmology.


Clinically silent anterior uveitis in secondary syphilis. 1 In a series of twenty patients with secondary syphilis, ten showed signs of overt or subclinical iritis alone. Nine showed signs of purely subclinical iritis. 2 Nineteen were Caucasian men and the one woman was an unmarried Caribbean nurse. 3 Of the nineteen men, fourteen were homosexuals. 4 All received adequate anti-syphilitic treatment as soon as the diagnosis was made, and all ocular signs of inflammation disappeared within 14 days.


Inflammation in the region of the vitreous base. Pars planitis.


Retinal, choroidal, and optic disc involvement in sarcoidosis.


Management of chronic uveitis.

Management of chronic uveitis.


Ultrasonography for patients with uveitis.


Kelman procedure in the treatment of complicated cataract of the uveitis of Still's disease.


Low centration guanethidine and adrenaline therapy of glaucoma. A preliminary report.


Uveitis and intraocular lenses.

Uveitis and intraocular lenses. Discs of polymethylmethacrylate containing 0-5 per cent. unpolymerized monomer were heated to create increasing concentrations of unpolymerized fragments up to 3-7 per cent. These fragments were then studied in tissue culture and in the anterior chambers of rabbits. No toxicity was evident in culture nor was there a difference in anterior segment response to the discs containing various concentrations of monomer. It would appear that the inflammatory response after implantation is predominantly mechanical in origin.


Immunological studies in keratoconus.

Immunological studies in keratoconus.


Subconjunctival injection of pilocarpine.


Dating the onset of cataract.

Dating the onset of cataract.


Delayed diagnosis of retrolental fibroplasia.


Ophthalmology in the undergraduate curriculum.


Fascia lata sling operation in ptosis surgery.


New lightweight sutured posterior chamber lens implant.


Survey of the first-degree relatives of glaucoma patients. Family histories were taken from 124 index patients, who had presented with either angle-closure or open angle glaucoma to the University Department of Ophthalmology, Manchester, between 1967 and 1972. Their first-degree relatives numbered 886, i.e. siblings, offspring and parents. Relatives were contacted by post and asked to attend for eye examination. Out of a total of 886 relatives, only 187 relatives were actually examined. The reasons for this low attendance rate are discussed; e.g. 423 relatives had already died.


Pathogenesis of craniofacial syndromes exhibiting colobomata.


Congenital colobomata of the eyelids.

Congenital colobomata of the eyelids.


Proplast implant in Tenon's capsule after excision of the eye. Hitherto implants used after enucleation have generally been extruded because of infection or tissue rejection. Proplast, an inert alloplastic material prepared from a combination of Teflon fluorocarbon polymer and vitreous carbon fibres, is a grey felt-like material which, when wholly implanted, is invaded by fibrous tissue and not rejected. Hemispherical implants of Proplast have been used in sixteen cases, no rejection has occurred to date (18 months), and movement of the implant has been good. At operation, the obliques are sutured posterior to the implant so as to hold it forwards and increase movement. The rectus muscles are sutured anterior to the implant in cruciate fashion. Tenon's capsule and the conjunctiva are closed separately.


Preliminary experience with lid magnets for paralytic lagophthalmos. Between February, 1974, and mid-December, 1975, 43 patients with paralytic facial palsy were operated upon with lid magnets, according to a method first devised by Mühlbauer and others (1973). When 37 patients were re-examined 3 months to 2 years post-operatively, 27 had both magnets in situ functioning well. In nine patients one or both magnets had been removed because of return of 7th nerve function. Including our information about those patients not available for re-examination, the method has definitely failed in only four. Cosmetically and functionally the results are subjectively as well as objectively encouraging and appear superior to a lateral tarsorrhaphy.


Palpebral cancers operated on before and after radiotherapy.


Surgical management of compensatory head posture.


Vascular changes after central retinal vein occlusion.


Pathophysiology of retinal vein occlusion.


Rationale for the treatment of diabetic retinopathy.


Measurement of retinal blood flow.

Measurement of retinal blood flow.