Some newly observed correlations between structure and photochemical activity in chlorophyllin a and several derivatives.


Splenic-gonadal fusion in a Japanese boy.


Some properties of Candida lipolytica yeast mitochondria.


Structural studies on the specific type VII pneumococcal polysaccharide.


Self-ideal-self discrepancy as a defensive style.


Studies of hyperimmune restricted and partially restricted anti-pneumococcal polysaccharide antibodies from allotype-defined pedigreed rabbits. I. Preparative liquid isoelectric focusing of the antibodies and characterization of the isolated fractions by electrophoretic techniques.


Studies of hyperimmune restricted and partially restricted anti-pneumococcal polysaccharide antibodies from allotype-defined pedigreed rabbits. II. Allotypes and idiotypes in sera and electrofocused fractions.


Sex differences in the metabolism of xenobiotics by extrahepatic tissue in rats.


Standardization of units in lung mechanics.


Study shows quick source for bacteria: foes among the flowers.


Studies on nitrite reductase from spinach leaves. I. Further purification and some properties.


Studies on the induction and expression of T cell-mediated immunity. 3. Amplification by papain of the generation of cytotoxic lymphocytes to allogeneic cells.


Suicide attempts with drug overdose. Outcomes of intensive vs conventional floor care.


Surgical Grand Rounds: Renal tumor.

Surgical Grand Rounds: Renal tumor.


Studies on respiration and 11 beta-hydroxylation of deoxycorticosterone in mitochondria and intact cells isolated from the Snell adrenocortical carcinoma 494.


Superinfections of the lung. An evaluation by serial transtracheal aspirations. A prospective evaluation of cephaloridine, cephalothin, and lincomycin was conducted in 85 patients with pneumonia. None of the 50 with previous history of allergic sensitivity to penicillin had an allergic reaction. All cases of pure "pneumococcal pneumonia" were cured, regardless of the drug. Eight patients with polymicrobial pneumonia were cured by the cephalosporins, while lincomycin was ineffective in four patients who had polymicrobial pneumonia. Although expectorated sputum and exudates from the nasopharyngeal and oropharyngeal areas contained large concentrations of Staphylococcus aureus and various Gram-negative bacillary species during and at the end of therapy, serial cultures of transtracheal aspirate and the clinical course failed to confirm "superinfection" of the lung.


Takayashu syndrome and pregnancy: a ten-year-follow-up.


Synthesis and biological activity of DL-3-(5-benzimidazolyl)-2-methylalanine.


Takayasu's disease, revisited.

Takayasu's disease, revisited.


The acute biochemical response of the starved rabbit liver in situ to glucose infusion.


Studies on the biotransformation of naphthalene-1,2-oxide in fetal and placental tissues of humans and monkeys.


The antagonism of the positive inotropic effect of histamine and noradrenaline by H1 and H2-receptor blocking agents.


The bleeding duodenal ulcer.

The bleeding duodenal ulcer.


The caries preventing effect of mouthrinsing with 0.025 percent sodium fluoride solution in Swedish children.


The development and introduction of new cardiovascular drugs. Seventh Bethesda Conference of the American College of Cardiology May 18-19, 1974, Washington D.C. Toxicology.


The cardiovascular effects of histamine in laboratory animals.


The development and introduction of new cardiovascular drugs. Seventh Bethesda Conference of the American College of Cardiology May 18-19, 1974, Washington, D.C. I. Views of a cardiologist.


The development and introduction of new cardiovascular drugs. Seventh Bethesda Conference of the American College of Cardiology May 18-19, 1974, Washington, D.C. II. Views of a Pharmaceutical manufacturer.


The development and introduction of new cardiovascular drugs. Seventh Bethesda Conference of the American College of Cardiology May 18-19, 1974, Washington, D.C. 3. Views of the food and drug Administration.


The effect of aerosol bronchodilators in the anaesthetized guinea-pig.


The effects of beta adrenergic blockade on the responses of leucocyte counts to intravenous epinephrine in man.


Sympathetic physiology and pharmacology.


The effects of substance P and other peptides on spinal neurons of the frog.


The effects of N,N-2-dichloroethylaniline ("aniline mustard") on the murine immune system.


The effect of phenobarbital pretreatment on the biotransformation of 3H-digitoxigenin to 6beta-hydroxy-3-epidigitoxigenin by rabbit liver homogenates.


The golden hamster as a definitive host of Taenia solium and Taenia saginata.


The immunological properties of haptens coupled to thymus-independent carrier molecules. II. The influence of the graft-versus-host reaction on primary antibody responses to hapten-coupled polysaccharides and proteins.


The effects of five preparatory methods upon child behavior during the first dental visit.


The measurement of affects: depression and anxiety.


The isolated organ-cultured supraoptic nucleus as a neuropharmacological test system.


The formation of complexes absorbing at 455 nm from cytochrome P-450 and metabloites of compounds related to SKF 525-A.


The in vitro hydrolysis of di-(2-ethylhexyl) phthalate by rat tissues.


The metabolism of polycyclic hydrocarbons by cultured human lymphocytes.


The physician's assistant.

The physician's assistant.


The metabolism of acetophenone oxime in rat liver homogenates.


The rat testis after vasectomy.

The rat testis after vasectomy.


The training and utilization of feldshers in the USSR. A review prepared by the Ministry of Health of the USSR for the World Health Organization.


The role of suppressor cells in avian allogeneic tolerance: implications for the pathogenesis of Marek's disease.


The presence of histamine H2-receptors in rabbit kidney.


The stimulation of partially purified bovine caudate tyrosine hydroxylase by phosphatidyl-L-serine.


The susceptibility of the fetus and child to chemical pollutants. Immunologic responses to chemical pollutants.


Three methods of nursing audit.

Three methods of nursing audit.


The unknown poison.

The unknown poison.


The use of allogeneic T lymphocytes and bacterial lipopolysaccharide to induce immune responses to monovalent haptens in vitro.


Tooth loss in a 19th century British population.


Toxic sympathicopathy in uraemia.

Toxic sympathicopathy in uraemia.


Validity and reliability of the Hooper Visual Organization Test.


The 2-hydroxylation of trans-cinnamic acid by chloroplasts from Melilotus alba Desr.


Variation in peroxisomal enzyme levels of peripheral leukocytes of cancer, leprosy, and tuberculosis patients.


World population year.

World population year.


24Epsilon-methylcholestane-3beta,5alpha,6beta,25-tetrol 25-monoacetate. A novel polyhydroxylated steroid from an alcyonarian.


Verapamil in cardiology.

Verapamil in cardiology.


150th anniversary of Louis Pasteur's birth celebrated in U.S.S.R.


Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.


6-Hydroxydopamine induced degeneration of noradrenaline neurons in the scorbutic guinea-pig.


Main characteristics of an induced decrease in leg motor reactivity ("desensitization") in the cockroach.


GABA as a transmitter in the central nervous system of vertebrates.


MMPI characteristics of mothers of pre-school children who are emotionally disturbed or have behavior problems.


Weak graft-versus-host response of CBA lymphocytes against the H-2-identical strain C3H.


Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus.


Role of a nurse on a psychiatric consultation service.


Mode of antagonism between beta-adrenergic drugs and prostaglandin F2-alpha.


Some immunochemical properties and species specificity of GABA-alpha-ketoglutarate transaminase from mouse brain.


Some properties of kidney cortex and splenic microsomal NADPH-cytochrome c reductase.


Some properties of guinea pig brain glutamate decarboxylase and its inhibition by the convulsant allylglycine (2-amino-4-pentenoic acid).


Some quantitative aspects of oxygen consumption and anaerobic metabolism of molluscan tissues--a review.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 47-1974.


GABA selectively blocks parallel fiber-Purkinje cell synaptic transmission in the frog cerebellum in vitro.


On a slow inhibitory effect of free fatty acids on the respiratory chain of non-phosphorylating submitochondrial particles from beef heart.


Fast recording ion specific microelectrodes: their use in pharmacological studies in the CNS.


Drug therapy. Benzodiazepines (second of two parts).


Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction.


Gamma-aminobutyric acid and nervous system function--a perspective.


Cell-mediated immunity and aging.

Cell-mediated immunity and aging.


Anti-receptor antibody and resistance to graft-versus-host disease.


Cell-mediated immunity after bacterial infection of the lower respiratory tract. Lower respiratory tract and systemic cell-mediated immunity have been studied in rabbits after infection with Listeria monocytogenes or Diplococcus pneumoniae. Respiratory tract cell-mediated immunity was evaluated by direct and indirect assays of migration inhibitory factor (MIF) production. Systemic delayed hypersensitivity was determined by means of intradermal testing with appropriate antigens. Aerosol exposure to listeria was followed by markedly increased numbers of free lower respiratory tract cells. These cells manifested antigen-stimulated inhibition of migration (mean inhibition of migration = 30.4%). Pneumococcal pneumonia was associated with similar but less dramatic changes. Intravenous administration of organisms was uncommonly followed by inhibition of lower respiratory tract cells in direct migration assays. Fractionated MIF, as well as crude supernates of antigen-stimulated lower respiratory tract and lymph node lymphocytes from animals exposed to listeria aerosols, caused inhibition of normal alveolar macrophage migration. MIF, produced by lymph node lymphocytes, has a molecular weight of approximately 65,000 and is inactivated by chymotrypsin or neuraminidase. Delayed dermal hypersensitivity to listeria antigen was observed in 54 of 55 animals exposed to listeria aerosols and in all 9 animals infected by the intravenous route. Delayed dermal reactions to pneumococcal sonicate antigen (but not capsular polysaccharide) followed D. pneumoniae respiratory tract infection in 19 of 28 animals, and was elicited in 5 of 6 animals after intravenous infection. Both local (macrophage migration inhibition) and systemic delayed hypersensitivity followed bacterial infection of the lower respiratory tract. MIF activity was shown to be one mechanism for inhibition of alveolar macrophage migration.


Infra-red TV for watching mosquito behaviour in the 'dark'.


Gamma-aminobutyric acid effects on pituitary gonadotropin secretion. Gamma-aminobutyric acid (GABA) injected into the third ventricle of male rats promotes the release of pituitary luteinizing hormone (LH) but not follicle-stimulating hormone. When GABA was injected directly into the pituitary it was ineffective in promoting LH release. This evidence suggests that GABA may play a role in controlling the discharge of hypothalamic luteinizing hormone releasing factor.


Gamma-aminobutyric acid synthesised in the olfactory nerve.


Gamma-aminobutyric acid: drug-induced elevation in monkey brain.


Dental caries, gingivitis, and oral hygiene among schoolchildren in Kampala, Uganda.


Beta-adrenergic receptor blocking drugs in cardiac arrhythmias.


Characteristics of crayfish neuromuscular facilitation and their calcium dependence. 1. A quantitative description of facilitation in the crayfish claw opener muscle is presented. The facilitation of a test response following one or more conditioning stimuli, and the growth of facilitation during a tetanus, are measured.2. In superficial central fibres facilitation following one or more impulses can be described as the sum of two components which are both maximum at the end of the conditioning train and decline simultaneously and exponentially with different time constants thereafter.3. During a tetanus, facilitation to successive stimuli grows more rapidly than is predicted by assuming that each impulse adds a constant facilitative effect to an accumulating total state of facilitation.4. Sufficiently large values of tetanic facilitation are predicted by a model which assumes that transmitter release is proportional to the nth power of a substance or factor accumulating in nerve terminals. But no single value of n predicts the correct rise of facilitation in a tetanus and the time course of its subsequent decline from the facilitation following a single spike.5. A model which assumes that the facilitative effects of successive spikes multiply in a tetanus predicts responses that are larger than those observed.6. The effects of varying the calcium concentration ([Ca(2+)]) on transmitter release and facilitation were studied. When a magnesium-EDTA buffering system is used to vary [Ca(2+)], transmitter release is found to be nearly linearly related to [Ca(2+)] in the range 0.1-13.5 mM.7. The magnitude and time course of facilitation during and following a tetanus are unaffected by varying [Ca(2+)] between 1.0 and 40 mM.8. The relation between ;steady-state' facilitation and stimulus frequency is also unaffected by changing [Ca(2+)], except that in high [Ca(2+)] transmitter release appears to saturate at high frequencies (above 30 Hz).9. The results are discussed in terms of the ;calcium accumulation' hypothesis of facilitation. The findings in crayfish appear to be qualitatively consistent with this hypothesis if certain modifications are made in the hypothesis.


Social constriction in psychiatric patients: a normative study.


A team approach to a disease survey on an aboriginal island (Orchid Island, Taiwan). IV. Mosquitos and chiggers on Lan-yü (Orchid Island), Taitung Hsien, Taiwan.


Glutamate synthase from Escherichia coli--an iron-sulfur flavoprotein. Separation and analysis of non-identical subunits.


Glutamate synthetase type activity in higher plants.


Glutamine synthetase and ammonium regulation of nitrogenase synthesis in Klebsiella.


Inflammation induced by histamine, serotonin, bradykinin and compound 48-80 in the rat: antagonists and mechanisms of action.


Glutamine synthetase as a regulator of enzyme synthesis.


Mechanism of ammonia assimilation in streptococci.


Mechanism of various drug effects on the Ca2+-dependent K+-efflux from human red blood cells.


Mechanized skin suturing.

Mechanized skin suturing.


Agoraphobia.

Agoraphobia.


Clozapine and haloperidol in a single-blind cross-over trial: therapeutic and biochemical aspects in the treatment of schizophrenia.


Clozapine in the maintenance therapy of schizophrenia.


Clozapine in outpatient practice.

Clozapine in outpatient practice.


Appearance of gamma aminobutyrate transaminase activity in developing rat brain.


Comparative aspects of glucose catabolism in Staphylococcus aureus and S. epidermidis.


Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes.


Comparative erythrocyte metabolism.

Comparative erythrocyte metabolism.


Comparative hematology: studies on elephants, Elephas maximus.


Richard Lende symposium.

Richard Lende symposium.


Comparative study of pyloric and fundic acid proteases in the guinea pig gastric mucosa: evidence for a pyloric pepsinogen.


Primary affective disorder: Bender-Gestalt sequence of placement as an indicator of impulse control.


Periarteritis nodosa--a compensable arterial condition?


Primate malarias.

Primate malarias.


The assessment of dental caries for public health purposes.


Release of (3H)gamma-aminobutyric acid from glial cells in rat dorsal root ganglia.


Isolation and characterization of melanocyte stimulating factors from the pituitary gland of the grey mullet, Mugil cephalus.


Isolation and partial characterization of a temperature-sensitive Escherichia coli mutant with altered glutaminyl-transfer ribonucleic acid synthetase. A temperature-sensitive mutant of Escherichia coli has been found in which the conditional growth is a result of a thermosensitive glutaminyl-transfer ribonucleic acid synthetase. The corresponding genetic locus glnS is cotransduced with lip. In a strain containing the mutationally altered glutaminyl-transfer ribonucleic acid synthetase, no derepression of the enzyme itself nor of glutamine synthetase was observed.


Oxidation of ethanol by hepatic microsomes of acatalasemic mice.


Isolation of cyclic AMP and cyclic GMP by thin-layer chromatography. Application to assay of adenylate cyclase, guanylate cyclase, and cyclic nucleotide phosphodiesterase.


Oxidation of fatty acids by mitochondria obtained from newborn subcutaneous (white) adipose tissue.


Isolation of rat liver peroxisomes.

Isolation of rat liver peroxisomes.


Comparison effects of metiamide and atropine on gastric and pancreatic secretion and peptic ulcer formation in cat.


Elevation of serum bilirubin and blood urea in pneumonia.


Periarteritis nodosa.

Periarteritis nodosa.


Oxidative metabolism of aflatoxin B1 by rat liver microsomes in vitro and its effect on lipid peroxidation.


The attachment of IgG to cell components: a reconsideration of Brambell's receptor hypothesis of protein transmission.


Is taurine an inhibitory neurotransmitter?


Inhibition of graft-versus-host-reaction (GVHR) by in vitro incubation of donor lymphocytes with thymic or splenic chalone (s).


Aerobic and anaerobic coproporphyrinogenase activities in extracts from Saccharomyces cerevisiae.


Inhibition of synaptic vesicular Mg+2 dependent ATPase ('stenin') by antipsychotic phenothiazines.


Antibody-dependent cell-mediated cytotoxicity. I. Differentiation from antibody-independent cytotoxicity by "normal" IgG.


Metabolic scope, oxygen debt and the diurnal oxygen consumption cycle of the leopard frog, Rana pipiens.


Metabolism of drugs. LXXXI. Further studies on metabolism of prolintane in rabbits.


Ionic composition of the plasma and whole blood of marine and fresh water eels, Anguilla rostrata.


The cardiomyopathies.

The cardiomyopathies.


Source of oxygen in the conversion of 2-tridecanone to undecyl acetate by Pseudomonas cepacia and Nocardia sp.


Source of reducing equivalents for the in vitro synthesis of chlorophyll from protochlorophyll.


Branchial innervation and ciliary control in the ascidian Corella.


Gas chromatography and electron capture detection of benzophenone. IX. Identification of the chromic acid oxidation product of pipradrol.


The chromosomes of giant trophoblast cells of the mouse.


Principles of immunology and their application to newer diagnostic techniques in allergy.


The clinical effect of salazosulphapyridine (Salazopyrin r) in Crohn's disease. A controlled double-blind study.


Effect of anaesthetic agents on the synthesis and disappearance of brain dopamine normally and after haloperidol, Kcl or axotomy.


Effect of anaphylaxis and histamine, pyrilamine and burimamide on levels of cyclic AMP and cyclic GMP in guinea-pig lung.


Effect of chronic morphine implantation on tyrosine hydroxylase activity in the rat caudate.


Effect of burimamide on histamine- and pentagastrin-stimulated acid and pepsin secretion in the pig.


Effect of delta-9-tetrahydrocannabinol on free amino acids in brain.


Effect of low calcium diet on bone and calcium metabolism in rats and mice--a differential species response.


Effect of diet on activity of enzymes involved in fatty acid and cholesterol synthesis.


Effect of metabolic inhibition on sodium ion exchange in the ventral nerve cord of Melanoplus differentialis.


Effect of non-opiate antagonists on stereospecific opiate receptor binding of tritiated naloxone.


Effect of washout of inducing steroid on gamma-glutamyl transferase activity in the cultured chick embryo retina.


Selected maturational changes observed in the postnatal rat brain.


Induction of tyrosine transaminase activity by hydrocortisone in vitamin B-6-deficient rats.


Induction of aryl hydrocarbon (benzo(a)pyrene) hydroxylase and tyrosine aminotransferase in hepatoma cells in culture. In the Reuber (H35) hepatoma cell strain, microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase is induced 25-fold by the polycyclic hydrocarbon benz[a]anthracene but is not induced by the steroid hormone dexamethasone. Soluble tyrosine aminotransferase is induced sixfold by dexamethasone and twofold by benz[a]anthracene. Each enzyme requires similar inducer concentrations for induction, and their induction kinetics are similar. The induction of each enzyme requires RNA and protein synthesis; in each case the transcriptional and translational steps can occur independently. The two induction systems are differentially sensitive to inhibitors of macromolecular synthesis. Simultaneous exposure to both inducers produces increases in both enzyme activities that are greater than those produced by either inducer alone. Each inducer acts at a pretranslational level to produce this synergistic effect. The results suggest that the requirements for macromolecular synthesis are similar for the induction of each enzyme, but that the turnover of enzyme-specific macromolecules may differ for each.


Selective solubilization of nicotinamide nucleotide transhydrogenase from the mitochondrial inner membrane.


Infectious complications in patients with combined immunodeficiency diseases receiving bone marrow transplants.


Effects of antimalarial drugs and clofibrate on in vitro lipid synthesis in Tetrahymena pyriformis GL.


Effects of alterations in impulse flow on transmitter metabolism in central dopaminergic neurons.


Effects of conjugated estrogens on plasma butaperazine levels.


Effects of cupric ions on the radiolytic inactivation of lactate dehydrogenase.


Effects of enflurane and fluroxene on lipid and carbohydrate metabolism in rats.


Effects of a simulated skylab mission on the oral health of astronauts.


Effects of lipid peroxidation on the microsomal electron transport system and the rate of drug metabolism in rat liver.


Effects of estradiol and nicotinamide adenine dinucleotide phosphate on the rate of synthesis of uterine glucose 6-phosphate dehydrogenase.


Effects of rapid and slow dehydration on the hemolymph osmolarity and Na+-K+ concentration in the millipede Pachydesmus crassicutis.


Effects of spirometrid plerocercoids on several species of lower vertebrates.


Effects of 6-hydroxydopamine on the nature of proteins undergoing axoplasmic transport in nigro-neostriatal neurons.


Lipid deposition and utilization in the sagebrush lizard, Sceloporus graciosus: its significance for reproduction and maintenance.


Structure of mitochondrial cristae membranes.


Rapid diagnosis of bacterial meningitis. Demonstration of bacterial antigen by counterimmunoelectrophoresis.


Sound reception and processing in the carp: saccular potentials.


A model for the mode of action of GABA on primary afferent terminals: depolarizing effects of GABA applied iontophoretically to neurones of mammalian dorsal root ganglia.


Immediate replantation and stabilization of avulsed teeth.


Blood groups and dental caries experience in man.


Sex differences in the endorsement of MMPI critical items.


Third special session of the Commission on Narcotic Drugs.


Noradrenaline-mediated inhibition by locus coeruleus of spinal trigeminal neurons.


Noradrenergic neurons: allosteric activation of hippocampal tyrosine hydroxylase by stimulation of the locus coeruleus.


Trace peptides with positive inotropic action in blood plasma of dogs. I. Chemistry and physiological significance of the peptide constituents of an intermediate molecular weight (1000-10,000 daltons) peptide fraction from heparinized dog blood plasma.


Nuclear magnetic resonance analysis of pharmaceuticals. 8. Carbromal and bromural in tablets.


Tanned silks.

Tanned silks.


Proceedings: Drug-induced stereotyped behavior: similarities and differences.


Proceedings: Effect of chronic treatment with central stimulants on brain monoamines and some behavioural and physiological functions in rats, guinea pigs, and rabbits.


Proceedings: Effects of alterations in impulse flow on transmitter metabolism in central dopaminergic neurons.


Proceedings: Effects of the pharyngo-cibarial armature of mosquitoes on microfilariae.


Proceedings: Multiparametric tests in the study of gastrointestinal neoplasms.


Proceedings: Short- and long-term regulation of tyrosine hydroxylase.


Proceedings: Short-term control of tyrosine hydroxylase.


Proceedings: The effects of beta-adrenergic blockade upon the cardiovascular responses of the rat to noradrenaline infusions.


The effect of external salinity upon lipid synthesis in the blue crab Callinectes sapidus Rathbun and in the spider crab Libinia emarginata Leech.


The effect of adrenergic blockade on the glucagon responses to starvation and hypoglycemia in man. In an attempt to ascertain whether the sympathetic nervous system modulates glucagon release in man during starvation and hypoglycemia, the influence of alpha and beta adrenergic blockade on glucagon responses was studied in young, healthy men subjected to fasting and insulin-induced hypoglycemia. Six volunteers fasted for 84 h on three separate occasions. Plasma immunoreactive glucagon (IRG), measured initially at 12 h, climbed gradually from mean levels of 54 pg/ml to a zenith of 124 pg/ml at 48 h, with maintenance of these levels for the duration of the fast. The infusion of propranolol or phentolamine throughout the terminal 24 h of the second and third fasts failed to alter the pattern of IRG release. After an overnight fast, five volunteers received insulin intravenously, which evoked a mean rise in plasma IRG levels from 63 pg/ml to a maximum of 256 pg/ml at 30 min. The concurrent administration of propranolol or phentolamine did not modify the glucagon responses to insulin-induced hypoglycemia. These data suggest that the augmented glucagon release in man during starvation or after hypoglycemia is not significantly regulated by signals from the adrenergic nervous system.


The effect of extra bound cytochrome b-5 on cytochrome P-450-dependent enzyme activities in liver microsomes.


The effect of immobilization and exercise on acetylcholine-mediated myopathies.


The effect of some beta-adrenergic blockers on human intraocular pressure.


The effect of salinity and temperature on the ion levels in the hemolymph of the blue crab, Callinectes sapidus, Rathbun.


The effect of sorbitol-containing chewing gum on the incidence of dental caries; plaque and gingivits in Danish schoolchildren.


The effectiveness of an adhesive sealant in preventing occlusal caries: findings after two years in Kalispell, Montana.


The effects of a new adrenergic blocking agent (K4423) on exercise tolerance in angina pectoris.


The effects of bovine prolactin, sea water and environmental calcium on water influx in isolated gills of the euryhaline teleosts, Anguilla japonica and Salmo gairdnerii.


The effects of hypnosis, relaxation and reinforcement on hypnotic behaviors and experiences.


Epidemiology of Boraceia virus in a forested area in São Paulo, Brazil.


Oxygen consumption of the beetle, Dermestes maculatus.


Oxygenational properties of haemerythrin in the blood of Magelona papillicornis Müller (Polychaeta: Magelonidae).


Subcellular myocardial effects of verapamil and D600: comparison with propranolol.


Evidence for a proton-dependent regulation of mitochondrial nicotinamide-nucleotide transhydrogenase.


Evidence for a relationship between ATP hydrolysis and changes in extracellular space and fibre diameter during rigor development in skeletal muscle.


Evidence for cooperative Mn-ATP binding with Bacillus sp. glutamine synthetase.


Evidence for the compartmentation of glutamate metabolism in isolated rat retina.


Evidence for the functional interaction of two central neurotransmitters.


Net energetic and thermoregulatory efficiency during panting in the sheep.


Congenital microgastria. A follow-up observation over six years.


Current concepts of allergy of the eye.

Current concepts of allergy of the eye.


Evidence for two different forms of guanylate cyclase in rat heart.


Concentration and analysis of organic volatiles in Skylab 4.


Letter: 'West syndrome'.

Letter: 'West syndrome'.


Letter: tRNA and ageing.

Letter: tRNA and ageing.


Letter: Clorazepate dipotassium in tardive dyskinesia.


Letter: E.C.T. and cardiac arrhythmia.

Letter: E.C.T. and cardiac arrhythmia.


Letter: Post-herpetic pruritus.

Letter: Post-herpetic pruritus.


Letter: Preliminary trial with a continuous helium-cadmium laser as excitation source for the microspectrofluorometric assay of NAD(P)H in single living cells.


Letter: Presweetened cereals.

Letter: Presweetened cereals.


Conferences view auto deaths: the 'neglected disease'.


Differential responses of two carboxylases from Euglena to the state of chloroplast development.


Bacterial otitis media in the guinea pig.


Bacteriocin of phage type 71 S. aureus.

Bacteriocin of phage type 71 S. aureus.


Patterns, range and effects of misused psychotropic substances in Europe.


Anxiety relief conditioning. A critical review and supportive experiment.


Review of behavioral treatment of depression.


Our experience with clozapine treatment.


Brief report of MMPI characteristics of sexual deviation.


Purification and kinetic properties of acyl and alkyl dihydroxyacetone phosphate oxidoreductase.


Crayfish neuromuscular facilitation activated by constant presynaptic action potentials and depolarizing pulses. 1. Experiments were conducted to test the hypothesis that facilitation of transmitter release in response to repetitive stimulation of the exciter motor axon to the crayfish claw opener muscle is due to an increase in the amplitude or duration of the action potential in presynaptic terminals. No consistent changes were found in the nerve terminal potential (n.t.p.) recorded extracellularly at synaptic sites on the surface of muscle fibres.2. Apparent changes in n.t.p. are attributed to three causes.(i) Some recordings are shown to be contaminated by non-specific muscle responses which grow during facilitation.(ii) Some averaged n.t.p.s exhibit opposite changes in amplitude and duration which suggest a change in the synchrony of presynaptic nerve impulses at different frequencies.(iii) Some changes in n.t.p. are blocked by gamma-methyl glutamate, an antagonist of the post-synaptic receptor, which suggests that these changes are caused by small muscle movements.3. The only change in n.t.p. believed to represent an actual change in the intracellular signal is a reduction in n.t.p. amplitude to the second of two stimuli separated by a brief interval.4. Tetra-ethyl ammonium ions increase synaptic transmission about 20% and prolong the n.t.p. about 15%. This result suggests that an increase in n.t.p. large enough to increase transmission by the several hundred per cent occurring during facilitation would be detected.5. The nerve terminals are electrically excitable, and most synaptic sites have a diphasic or triphasic n.t.p., which suggests that the motor neurone terminals are actively invaded by nerve impulses.6. When nerve impulses are blocked in tetrodotoxin, depolarization of nerve terminals increases the frequency of miniature excitatory junctional potentials (e.j.p.s), and a phasic e.j.p. can be evoked by large, brief depolarizing pulses. Responses to repetitive or paired depolarizations of constant amplitude and duration exhibit a facilitation similar to that of e.j.p.s evoked by nerve impulses.7. It is concluded that facilitation in the crayfish claw opener is not due to a change in the presynaptic action potential, but is due to some change at a later step in the depolarization-secretion process.


The gallbladder of the guinea pig: its concentrating and contractile abilities.


Changes in enzyme patterns produced by high potassium concentration and dibutyryl cyclic AMP in organ cultures of sympathetic ganglia.


Changes in the MMPI as a function of thalamotomy.


Changes of kinetic constant of striatal tyrosine hydroxylase elicited by neuroleptics that impair the function of dopamine receptors.


The eye and its disorders. 24. The treatment of external diseases.


I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR). Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.


(3H)glutamate uptake at insect neuromuscular junctions: effect of chlorpromazine.


Inaugural address: 49th all-India medical conference.


Antagonists of the putative inhibitory transmitter effects of taurine and GABA in the retina.


On the induction of tyrosine aminotransferase in rat liver by alpha-methyl-p-tyrosine.


Saccharopine dehydrogenase. A kinetic study of coenzyme binding.


On the mechanism of glucose-6-phosphate dehydrogenase regulation in mouse liver. 1. Characterization of the system.


On the nature of the interhemispheric effects of fatigue.


Biochemical changes of myocardial necrosis induced by isoproterenol and protective effects of beta-blocker and anti-inflammatory drugs.


Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver.


Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion.


Posthepatitis syndromes.

Posthepatitis syndromes.


Further clinical and EEG experience with clozapine.


Further results of catches of Culicoides (Diptera: Ceratopogonidae) and mosquitoes from suction traps.


Synthesis of dl-3-(hydroxymethyl)tyrosine.


Teaching family medicine: progress report.


Teichoic acid phosphorylcholine esterase. A novel enzyme activity in pneumococcus.


Psychological aspects of pain and the selection of patients.


The hyperactive child: who is he?

The hyperactive child: who is he?


Aortic calcification, serum calcium, magnesium, sodium and cholesterol in Gopherus polyphemus.


Chemical and immunological characterisation of the major glucosamine-containing ganglioside of human tissues.


Clinical experience with clozapine in psychoses.


Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors.


Clinical studies of livedoid vasculitis: (segmental hyalinizing vasculitis).


Physical therapy education: the future.

Physical therapy education: the future.


Chemicals as tools in the study of excitable membranes.


Multicore disease: report of a case with onset in middle age.


Presidential address: Cancer as a specialty. Where have we been?


Studies in dentifrices, 8: clinical testing of an acidulated, nongrinding dentifrice with reduced fluorine contents.


Studies on the amino acids of the tsetse fly, Glossina morsitans, maintained on in vitro and in vivo feeding systems.


Studies on new beta-adrenergic blocking agents. II. Syntheses and pharmacology of 2-anilinotropone derivatives.


Studies on the gill of Mytilus edulis: the eu-latero-frontal cirri.


Studies on the transport of L-tyrosine into an adrenergic clone of mouse neuroblastoma.


Studies on the NADPH oxidizing activity in polymorphonuclear leucocytes. The mode of association with the granule membrane the relationship to myeloperoxidase and the interference of hemoglobin with NADPH oxidase determination.


Profile generalizability in the use of the MMPI with psychiatric inpatients.


Vertigo in childhood. Comments on pathogenesis and management.


Specificity of in vitro murine B cell activation by protein and polysaccharide polymers.


Preliminary characterization studies on the Neisseria catarrhalis respiratory electron transport chain. The Neisseria catarrhalis respiratory electron transport system was examined in a sonic type particulate membrane fraction and shown to have a moderately active succinate as well as nonpyridine nucleotide-dependent dl-lactate oxidoreductase and a very active tetramethyl-p-phenylenediamine oxidase. l-Malate and l-glutamate oxidation were found to be dependent on pyridine nucleotides and exclusively associated with a soluble (or nonmembranous) fraction. The primary cytochrome components in the electron transport system appear to be c-type in nature (555 nm and 550 nm) as well as cytochrome a(1) (600 nm) and cytochrome o.


The incorporation of tritium in the body water and organic matter of selected marine invertebrates.


The influence of capture and transportation on some blood parameters of fresh water fish.


Origins and evolution of the human malarias: the role of the vector.


The influence of serotonin, GABA and DL-dopa on the circadian rhythm in the toxicity of picrotoxin, pentylenetetrazol and phenobarbital in mice.


Symbiosis of the acoel flatworm Convoluta roscoffensis with the alga Platymonas convolutae.


Cardiovascular histamine receptors in the rabbit.


Impairments in hormonal control of liver enzyme activity in aging rats.


A critical assessment of methods for the determination of monoamine synthesis turnover rates in vivo.


Sensitivity of restrained skipjack tuna (Katsuwonus pelamis) to abrupt increases in temperature.


Sensitization and dishabituation in the cockroach. Main characteristics and localization of the changes in reactivity.


Isocitric dehydrogenase activity in non-inflamed attached gingiva of rhesus monkeys.


Physiological response to the submarine environment.


Longitudinal trend in prescribing psychotropic drugs.


Cardiovascular changes following DOCA-NaCl or conditioning in 6-hydroxydopamine-treated rats.


Renal sodium reabsorption in the hagfish, Eptatretus stouti.


Uptake mechanisms for neurotransmitter amines.


Regulation by salt and by Krebs cycle metabolites of citrate synthase from an osmoregulator, white shrimp, Penaeus setiferus, and from a non-osmoregulator, sea anemone, Bunedosoma cavernata.


Regulation of catecholamine synthesis in the rat brain in vitro by cyclic AMP.


Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes.


Regulation of larval corpora allata in Galleria mellonella.


Regulation of lipogenesis in animal tissues.


Problems associated with biological age.


Problems associated with iontophoretic studies in the caudate nucleus and substantia nigra.


Problems in interpreting neurochemical changes occurring in developing and aging animals.


Completely isolated neurons in the mollusc, Lymnaea stagnalis. A new objective for nerve cell biology investigation.


Simplified models of population dynamics of mosquitoes related to control technology.


Familial progressive external ophthalmoplegia and ragged-red fibers.


Forelimb blood flow and saliva spreading in the thermoregulation of the red kangaroo, Megaleia rufa.


Ganglion blocking effect of indole alkaloids contained in Uncaria genus and Amsonia genus and related synthetic compounds on the rat superior cervical ganglion in situ.


Facilitation of avoidance acquisition in the rat by ethanol and its abolition by alpha methyl p-tyrosine.


Axially projected collagen structures.

Axially projected collagen structures.


Development of lipogenesis in rat brain cortex: the differential incorporation of glucose and acetate into brain lipids in vitro.


Development of tumors as a result of graft-versus-host reaction.


Developmental characteristics of phenylethanolamine and octopamine in the rat brain.


3-(Alpha-(tert-butylamino)methyl)-5-hydroxy-m-xylene-alpha, alpha'-diol, a selective bronchodilator.


Results achieved with clozapine (leponex) in the treatment of neuroses.


Hemolymph characteristics of developing adult tobacco hornworms reared as larvae on tobacco leaf or synthetic diet.


Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes.


The lymphocyte surface. I. Relation between Fc receptors, C'3 receptors and surface immunoglobulin.


The lymphocyte surface. II. Separation of Fc receptor, C'3 receptor and surface immunoglobulin-bearing lymphocytes.


Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-receptor antagonists.


Pharmacological properties of a potential tranquilising agent mesylphenacyrazine. I. Interaction with drugs influencing the nervous system.


Pharmacology of aconitine-induced automaticity on in vitro cat myocardial preparations. II. Effects of refractory period prolongation, reduced sodium and tetrodotoxin.


Chromatography of the 1,4-benzodiazepines.


Pharmacology of the adrenergic mechanism.


The maturation of indoleamine metabolism in the lateral eye of the mouse.


Sedimentation velocities of cells mediating two different GVH lesions.


Enzyme localization in the anaerobic mitochondria of Ascaris lumbricoides. Mitochondria from the muscle of the parasitic nematode Ascaris lumbricoides var. suum function anaerobically in electron transport-associated phosphorylations under physiological conditions. These helminth organelles have been fractionated into inner and outer membrane, matrix, and intermembrane space fractions. The distributions of enzyme systems were determined and compared with corresponding distributions reported in mammalian mitochondria. Succinate and pyruvate dehydrogenases as well as NADH oxidase, Mg(++)-dependent ATPase, adenylate kinase, citrate synthase, and cytochrome c reductases were determined to be distributed as in mammalian mitochondria. In contrast with the mammalian systems, fumarase and NAD-linked "malic" enzyme were isolated primarily from the intermembrane space fraction of the worm mitochondria. These enzymes are required for the anaerobic energy-generating system in Ascaris and would be expected to give rise to NADH in the intermembrane space. The need for and possible mechanism of a proton translocation system to obtain energy generation is suggested.


The metabolism of carbohydrates by extremely halophilic bacteria: glucose metabolism via a modified Entner-Doudoroff pathway.


Parameters of oxygen delivery in the species Marmota flaviventris: at sea level and 12,000 feet.


The metabolism of some thioureidobenzene fungicides in mice and sheep.


Dynamics of transmissional ultrastructures in sympathetic neurones on the rat.


Dopamine-beta-hydroxylase and the regulation of the noradrenergic neuron.


Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow.


Pneumococci relatively insensitive to penicillin in Australia and New Guinea.


Thermodynamic relationships in mitochondrial oxidative phosphorylation.


Thermoregulation in crocodilians. I. Head-body temperature control in the papuan-New Guinean crocodiles, Crocodylus novaeguinea and Crocodylus porosus.


A comparison of the effects of GABA and imidazoleacetic acid on the membrane conductance of lobster muscle fibres.


An improved NADH-dependent transketolase assay for assessing thiamine nutriture.


An improved synthesis of thyrotropin releasing hormone (TRH) and crystallization of the tartrate.


A comparative study of acute myocardial infarction in the rabbit, cat and man.


Minimum duration of trans-synaptic stimulation required for the induction of tyrosine hydroxylase by reserpine in the rat superior cervical ganglion.


Coronary artery aneurysms in a 9-year-old child.


Absence of involvement of glutamine synthetase and of NAD-linked glutamate dehydrogenase in the nitrogen catabolite repression of arginase and other enzymes in Saccharomyces cerevisiae.


Perinatal drug metabolism and morphological changes in the hepatocytes of normal and phenobarbital-treated guinea pigs.


Adrenergic agents. 2. Synthesis and potential beta-adrenergic agonist activity of some ring-chlorinated relatives of isoproterenol.


Enhanced phagocytic capacity. The biologic basis for the elevated histochemical nitroblue tetrazolium reaction. The biologic basis for the elevated histochemical reduction of nitroblue tetrazolium dye (NBT) in neutrophils from patients with acute bacterial infection or polycythemia vera was studied. A precipitin reaction followed mixing NBT with heparin. NBT was reduced after phagocytosis of this complex (H-NBT) by polymorphonuclear leukocytes (PMNs). Ingestion required divalent cations and was facilitated by the presence of complement. H-NBT incubated with normal but not with C2-deficient human serum converted native C3 to its inactive form. Phagocytic indices were determined in patients and controls by measuring O(2) utilization and hexose monophosphate shunt activity and by visually counting cell-associated latex particles. Significant elevations above controls were observed in phagocytes isolated from all patients with elevated histochemical NBT scores when H-NBT complex, latex, or zymosan was employed as the phagocytic particle. Increased indices were observed in the presence of fresh AB serum, heat-inactivated AB serum, or without serum. Serum from patients with elevated NBT scores did not alter phagocytosis in control phagocytes. With NADH and NADPH as substrates, total NBT diaphorase activity of sonicated leukocytes was normal in all patients. These results suggest that increased phagocytic capacity of PMNs is the primary cause of increased histochemical NBT reduction. The PMNs of patients with acute bacterial infection or polycythemia vera may have alterations in their cell membranes which lead to an enhanced rate of phagocytosis.


Planning cooperation in human bone marrow transplant research. A report of the special meeting of the cooperative group on bone marrow transplantation in man, September 23, 1972, Wingspread, Racine, Wisconsin.


Ethanol oxidation by components of rat liver microsomes.


Immunologic activation of murine leukemia viruses.


Immunologic theory of aging: current status.


Immunological activation of oncogenic viruses: interrelationship of immunostimulation and immunosuppression.


Desensitization by leg contact in the cockroach: localization of the reactivity changes and a study of their possible sensory origin.


Immunopathology of viral hepatitis in man.


Reconstitution of light-dependent electron transport in membranes from a bacteriochlorophyll-less mutant of Rhodopseudomonas spheroides.


A controlled comparison of chlorazepate with oxazepam in neurotic anxiety.


An investigation of the neural mechanisms controlling the colour change responses of the dogfish, Scyliorhinus canicula L. by mesencephalic and diencephalic lesions.


Amino acid and serotonin content in the nervous system, muscle and blood of the cockroach Periplaneta americana.


Androblastoma--sertoli cell tumor.

Androblastoma--sertoli cell tumor.


Photochemical activity and components of membrane preparations from blue-green algae. I. Coexistence of two photosystems in relation to chlorophyll a and removal of phycocyanin.


Histochemical and tissue culture studies of dystrophic and experimentally denervated animal muscle.


Dissociation of the effect of adrenalin on glucose uptake from that on adenosine cyclic 3',5'-monophosphate levels and on lipolysis in rat-isolated fat cells.


Use of the MMPI with patients with recent war-related head injuries.


Hydrogen ion activity in polychaete body fluids.


Photoinactivation of NAD-glucohydrolase from rabbit heart.


Welcome address: 49th all-India medical conference.


Regional variation in alanine absorption in the gut of Echinus esculentus.


Seasonal anaemia in the Rottnest quokka, Setonix brachyurus (Quoy & Gaimard) (Marsupialia; Macropodidae).


Personality correlates of visual perceptual responses.


Personality type, reports of violence, and aggressive behavior.


Pulmonary ascorbic acid loss induced by catecholamines.


Response of dermal melanophores to epinephrine after removal of the epidermal barrier.


Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.


Evaporative water loss and tissue dehydration of hamsters in the heat.


Neuropsychopharmacology of monoamines and their regulatory enzymes.


Editorial: Histamine H2-receptor antagonists, gastric secretion and duodenal ulcer.


Editorial: Hypertensive crises in pregnancy.


Editorial: Penicillin-resistant pneumococci and pneumonia.


Editorial: Report of the Committee on Contrast Media of the International Society of Radiology.


Editorial: Shrinking the myocardial infarct.


Factors affecting the biochemical maturation of the brain. Effect of undernutrition during early life.


Factors associated with failure of lumbar spine fusion.


Purpose-in-life and the Eysenck personality inventory.


Glucose-6-phosphate dehydrogenase: comparison of kinetic contants among different breeds of sheep.


A cross-validation of seventeen experimental MMPI scales related to antisocial behavior.


Testosterone formation in testis of the immature androgen insensitive pseudohermaphrodite male rat (Stanley-Gumbreck rat).


Neurotransmitter synthesis by two clonal nerve cell lines: changes with culture growth and morphological differentiation.


Improved oral health of schoolchildren of 16 communities after 8 years of prevention. I. Combining DMF data from the communities.


Group therapy with obese women of varying MMPI profiles.


Hydroxylations of bile acids by reconstituted systems from rat liver microsomes.


The pathology of bone marrow transplantation.


The personality in psychomotor epilepsy compared with the explosive and aggressive personality.


A rapid, simple method for the isolation of rat brain microsomes.


Relapsing pneumococcal meningitis: isolation of an organism with decreased susceptibility to penicillin G.


The psychotherapy of schizophrenia.

The psychotherapy of schizophrenia.


Synaptochemistry. Outlines and scope of a discipline.


Water balance of a euryhaline sea anemone, Diadumene leucolena.


Contractile properties of muscle: control by pattern of muscle activity in the rat.


Contractile actions of antihistamines on isolated arterial smooth muscle.


Interaction of hydrocortisone and dibutyryl cyclic AMP in the induction of tyrosine amino-transferase and phosphoenolpyruvate carboxy-kinase in rat liver.


Interactions between oxidative metabolism and acid secretion in gastric mucosa.


Central action of bicuculline.

Central action of bicuculline.


An oral health survey of Manono-tai, Western Samoa.


Alteration of psychosomatic reactivity after a single therapeutic dose of pentobarbital in relation to the sex of probands.


Maturational changes in the ovarian lipid spectrum of the pink shrimp, Penaeus duorarum duorarum Burkenroad.


A direct radioimmunoassay for mouse casein.


Osmoregulatory responses to DDT and varying salinities in Salmo gairdneri. I. Gill Na-K-ATPase.


The respiration in air and in water of the limpets Patella caerulea (L.) and Patella lusitanica (Gmelin).


The response of "obese" (ob-ob) and "diabetic" (db-db) mice to treatments that influence body temperature.


Suppression of erythropoiesis by simultaneous proliferation of alloantigen-sensitive units.


Suppression of graft-versus-host reaction in rats by cell-free extract from heterologous liver.


Allergic headaches.

Allergic headaches.


Inheritance of the Aarskog syndrome.

Inheritance of the Aarskog syndrome.


Distribution of the enzymes involved in the disposal of arginine and ornithine in different regions of rat brain.


Determination of clonazepam and flunitrazepam in blood by electron-capture gas-liquid chromatography.


Synergistic actions of nitrite-beta-adrenergic blocking agents in the therapy of angina pectoris. Pharmacologic and therapeutic rationale.


Interneuronal activity as a factor interfering with the interpretation of results from microiontophoretic studies.


The role of phosphotransferase-mediated syntheses of fructose 1-phosphate and fructose 6-phosphate in the growth of Escherichia coli on fructose.


The role of estrogens in primate reproduction: a Brook Lodge workshop.


Environmental modification of mammalian drug metabolism and biological response.


The role of physicians' assistants in a university teaching service.


Control of utero-ovarian and peripheral venous plasma progesterone by beta-sympathomimetic drugs in pregnant sheep.


The role of histamine receptors in the stimulation of gastric acid secretion.


Observations on the amphibian "diaphragm".


Bends in fish.

Bends in fish.


Dye-salt formation as a general method for colorimetric determination of antihistaminics. I. The use of methyl orange for the determination of chlorphenamine, diphenhydramine and chloropyramine in pharmaceutical preparations.


Dye salt formation as a general method for colorimetric determination of antihistaminics. Part 2: Spectrophotometric determination of thenalidine maleate and thiazinamium methylsulphate in pure and dosage forms.


The scientific background of the International Sanitary Conferences, 1851--1938. 3.


A case of true hermaphroditism presenting as an undescended testicle.


Expert group on drugs in modern society: community reactions to drug use by young people.


Transmitter release induced by a 'factor' in rabbit serum.


Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction.


The structure of somatic and psychic neurotic symptoms in prisoner-toxicomans.


Trait interrelations in implicit personality theories and questionnaire data.


[Sepsis and hemolytic-uremic-syndrome (author's transl)].


Short- and long-term regulation of tyrosine hydroxylase.


Short-term control of tyrosine hydroxylase.


Graft-versus-host disease. Modification with concanavalin A.


Graft-versus-leukemia. V. Absence of antileukemic effect using allogeneic h-2-identical immunocompetent cells.


PTC tasting and dental caries.

PTC tasting and dental caries.


Low temperature studies of microsomal cytochrome P450. Release of oxidizing species.


Maintenance treatment of schizophrenia with long-acting fluphenazine.


Meiotic duration in wheat genotypes with or without homoeologous meiotic chromosome pairing.


Genetic aspects of monoamine mechanisms.


Hepatic tryptophan oxygenase activity as a marker of changes in protein metabolism during chronic ethanol treatment.


Genetical analysis of fructose utilization by Escherichia coli.


Relation of the second messenger system to the electrogenesis and regulation of the contraction in the heart cell membrane of insecta.


Nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase from Clostridium thermoaceticum: purification and properties. The nicotinamide adenine dinucleotide phosphate (NADP)-dependent formate dehydrogenase in Clostridium thermoaceticum used, in addition to its natural electron acceptor, methyl and benzyl viologen. The enzyme was purified to a specific activity of 34 (micromoles per minute per milligram of protein) with NADP as electron acceptor. Disc gel electrophoresis of the purified enzyme yielded two major and two minor protein bands, and during centrifugation in sucrose gradients two components of apparent molecular weights of 270,000 and 320,000 were obtained, both having formate dehydrogenase activity. The enzyme preparation catalyzed the reduction of riboflavine 5'-phosphate flavine adenine dinucleotide and methyl viologen by using reduced NADP as a source of electrons. It also had reduced NADP oxidase activity. The enzyme was strongly inhibited by cyanide and ethylenediaminetetraacetic acid. It was also inhibited by hypophosphite, an inhibition that was reversed by formate. Sulfite inhibited the activity with NADP but not with methyl viologen as acceptor. The apparent K(m) at 55 C and pH 7.5 for formate was 2.27 x 10(-4) M with NADP and 0.83 x 10(-4) with methyl viologen as acceptor. The apparent K(m) for NADP was 1.09 x 10(-4) M and for methyl viologen was 2.35 x 10(-3) M. NADP showed substrate inhibition at 5 x 10(-3) M and higher concentrations. With NADP as electron acceptor, the enzyme had a broad pH optimum between 7 and 9.5. The apparent temperature optimum was 85 C. In the absence of substrates, the enzyme was stable at 70 C but was rapidly inactivated at temperatures above 73 C. The enzyme was very sensitive to oxygen but was stabilized by thiol-iron complexes and formate.


Fractionation of the electron-transport chain of Escherichia coli.


Relationship between antihistamic activity and plasma level of diphenhydramine.


Reactivation of immunocompetence in spleen cells of aged mice.


Adaptive phenomena in bone marrow transplantation.


Inactivation of nitrate reductase by NADH in Nitrobacter agilis.


Nematode biochemistry. XIII. Peroxisomes in the free-living nematode, Turbatrix aceti.


Relationship of Streptococcus mutans carrier status to the development of carious lesions in initially cariesfree recruits.


Identification and differentiation of organic medicinal agents. VII. Some newer antihistamines and a miscellaneous group of drugs.


Hematological values of some great flying and aquatic-diving birds.


Electrically induced relaxation in systematic desensitization: a case note.


Peritrophic membranes in the midgut of pupal and pre-blood meal adult mosquitoes (Diptera: Culicidae).


Electrophoretic studies on gene-enzyme systems in mosquitoes (Diptera, Culicidae).


The type-specific substance from Pneumococcus type 33B. 1. The type-specific substance, S. 33B, from Pneumococcus type 33B contains P, 2.89; hexose, 51; total sugar, 69; galactosamine, 18; and d-glucose, 20%. 2. After degradation with alkali, followed by enzymic dephosphorylation, S. 33B yielded a hexasaccharide. 3. The hexasaccharide was assigned the structure O-beta-d-glucopyranosyl- (1-->5)-O-beta-d-galactofuranosyl- (1-->3)-O-2-acetamido-2-deoxy-beta-d- galactopyranosyl-(1-->4)-O-[alpha-d- galactopyranosyl-(1-->2)]-alpha-d-galactopyranosyl- (1-->2)-ribitol. 4. Phosphate residues in S. 33B are located on the hydroxyl groups at position 5 of ribitol units and on the hydroxyl groups at position 6 of hexopyranose residues.


Evaluation of a fluoride prophylaxis paste in a fluoridated community.


A double-blind study on the effects of piracetam upon perceptual and psychomotor performance at varied heart rates in patients treated with artificial pacemakers.


Rescue from canine graft-versus-host reaction by autologous or DL-A-compatible marrow.


Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex.


Influence of dietary fatty acids on the composition of plasma fatty acids in the tundra wolf (Canis lupus tundrarum).


Influence of morphine and naloxone on the release of noradrenaline from rat brain cortex slices.


Influence of periodicity of eating on intestinal glycolytic enzymes in the rat.


Influence of noncholinergic drugs on rat striatal acetylcholine levels.


Influence of the cardiac sympathetics on left ventricular dynamics during tachycardia.


Influence of GABA and glycine and their antagonists on inhibitory mechanisms of pigeon's optic tectum.


Convulsant drugs: amino acid antagonism and central inhibition.


Measurement of inorganic pyrophosphate in biological fluids and bone tissues.


The use of systemic immunity adjuvants in the prophylaxis or therapy of cancer.


The utilization of physician assistants in geographically remote areas.


Evolutionary aspects of transmitter heterogeneity.


The value of blood culture in the diagnosis of pneumococcal pneumonia.


Activation of methionine synthetase by a reduced triphosphopyridine nucleotide-dependent flavoprotein system.


Activation of NADH oxidase by succinate in partially ubiquinone-depleted submitochondrial particles.


The vertical distribution of mosquitoes flying over open farmland in the Gambia.


Active chloride transport across the skin of the earthworm, Lumbricus terrestris L.


Arbovirus studies in Houston, Texas, 1968-1970.


Overwintering of arboviruses.

Overwintering of arboviruses.


Redox changes of cytochrome alpha-607 and NAD(P)H in rat liver mitochondria induced by L-malate under anaerobic conditions.


Takayasu's arteritis. An angiographic study with remarks on ethnic distribution in Israel.


Delayed secondary disease in mice after early or late therapy with anti-thymocyte serum.


Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyltransferase, and carboxyl carrier protein components.


Acetyl coenzyme A carboxylase system of Escherichia coli. Site of carboxylation of biotin and enzymatic reactivity of 1'-N-(ureido)-carboxybiotin derivatives.


Acetyl coenzyme A carboxylase system of Escherichia coli. Studies on the mechanisms of the biotin carboxylase- and carboxyltransferase-catalyzed reactions.


Acetyl coenzyme A carboxylase.

Acetyl coenzyme A carboxylase.


Acetylcholine levels in the frog spinal cord following the administration of different convulsants.


Biosynthesis of free amino acids in the brain of Jimpy mice.


The APUD cell concept and its implications in pathology.


NADPH-dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes.


Mechanistic studies of glutamine synthetase from Escherichia coli. Fluorometric identification of a reactive intermediate in the biosynthetic reaction.


The effect of histidine modification on the activity of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli B.


Bioluminescence in coelenterates.

Bioluminescence in coelenterates.


Interaction of S-100 protein with cations and liposomes.


The respiratory system of the marine bacterium Beneckea natriegens. II. Terminal branching of respiration to oxygen and resistance to inhibition by cyanide.


Redox potentiometry in mitochondrial and photosynthetic bioenergetics.


Non-pyridine nucleotide dependent L-(plus)-glutamate oxidoreductase in Azotobacter vinelandii.


Biosynthesis of fatty acids in vitro by homogenate of developing rat brain: desaturation and chain-elongation.


Purification of gamma-glutamyltransferase of rat kidney by affinity chromatography using concanavalin A conjugated with sepharose 4B.


Changes in cell permeability following a marked reduction of saturated fatty acid content of Escherichia coli K-12.


Long-term perfusion of the isolated rat liver: maintenance of its functional state by use of a fluorocarbon emulsion.


Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.


The pupae of vector mosquitoes.

The pupae of vector mosquitoes.


Prostaglandins, kinin and inflammation in the rat. 1 Prostaglandin E(1) and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E(2) is inactive in this respect.2 Prostaglandin F(2alpha) reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5-hydroxytryptamine and histamine.3 Prostaglandin E(1) and dextran exert synergistic effects in rat skin when threshold doses of each agent are used.4 Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E(1).


Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro. 1 Potential changes in rat superior cervical ganglia were recorded in vitro with surface electrodes.2 gamma-aminobutyric acid (GABA) produced a transient, low-amplitude ganglion depolarization at rest, and a transient hyperpolarization in ganglia depolarized by carbachol. Depolarization was not prevented by preganglionic denervation. The log dose-response curve for depolarization was sigmoid with a mean ED(50) of 12.5 muM.3 The ganglion was depolarized in similar manner by the following compounds (mean molar potencies relative to GABA (=1) in brackets): 3-aminopropane sulphonic acid (3.4), gamma-amino-beta-hydroxybutyric acid (0.27), beta-guanidino-propionic acid (0.12), guanidinoacetic acid (0.057), delta-aminovaleric acid (0.048), beta-alanine (0.01), 2,4-diaminobutyric acid, gamma-guanidinobutyric acid, taurine and N-methyl-GABA (all <0.01). The following compounds did not depolarize the ganglion at 10 mM concentrations: alpha- and beta-amino-n-butyric acids, alpha-amino-iso-butyric acid, glycine and glutamic acid.4 Depolarization declined in the continued presence of GABA. Ganglia thus ;desensitized' to GABA showed a diminished response to other amino acids but not to carbachol.5 The effect of GABA was not antagonized by hyoscine and hexamethonium in combination, in concentrations sufficient to block responses to carbachol.6 Responses to GABA were blocked more readily than those to carbachol by bicuculline (IC(50), 14 muM) and picrotoxin (IC(50), 37 muM). Strychnine (IC(50), 73 muM) was a relatively weak and less selective GABA-antagonist.7 It is concluded that sympathetic ganglion cells possess receptors for GABA and related amino acids which are (a) different from the acetylcholine receptors and (b) similar to GABA receptors in the central nervous system.


Letter: Beta-adrenergic blocking agents in patients with renal failure.


Blood muramidase activity in colorectal cancer. The serum muramidase levels were measured in 128 patients with primary or metastatic colorectal cancer, 166 tumour-free patients after resection of a colorectal cancer, and 172 controls. Muramidase levels over 10 mug/ml were detected in 30%-39% of the tumour-bearing patients, in 8.2% of the tumour free, and in only 1.7% of the controls (normal level 6.68 +/- 1.42 mug/ml). Long-term follow up indicated that raised levels may occur as a transient phenomenon in recurrent or metastatic disease. The likely relation of abnormal serum muramidase activity and stimulation of the reticuloendothelial system is discussed.


Letter: Hypertension and myocardial infarction.


Prevention of exercise-induced asthma by indoramin. Indoramin, an alpha-adrenoceptor blocking drug, has been found to prevent the occurrence of exercise-induced bronchoconstriction. Evidence is provided in two cases that this was not due to the antihistamine properties of indoramin.


Prenatal diagnosis of galactosaemia.

Prenatal diagnosis of galactosaemia. We have monitored two pregnancies from families at risk for galactosaemia. The fetus was diagnosed as having galactosaemia in one and to be unaffected in the other. The accuracy of the predictions was confirmed postnatally. Assays for galactose 1-phosphate uridyl transferase involving the reduction of the coenzymes NAD or NADP are unsuitable for amniotic cells whereas estimation of (14)C-UDP-galactose produced from (14)C-galactose 1-phosphate detected the homozygous mutant fetus.


Letter: Alpha-adrenoceptor-blocking drugs in asthma.


Bites by the saw-scaled or carpet viper (Echis carinatus): trial of two specific antivenoms. Echis carinatus is the most important cause of morbidity and mortality from snake bite in Nigeria and in many other parts of the world. Forty-six patients with systemic poisoning by this snake were given echis antivenom made either by the South African Institute for Medical Research (S.A.I.M.R.) or by Behringwerke (North and West African polyvalent antivenom). A simple test of blood coagulability was used to assess whether an adequate neutralizing dose of antivenom had been given. An average of 15.2 ml S.A.I.M.R. antivenom restored normal coagulability permanently in all 23 patients in one group, but in the other group receiving an average dose of 37.9 ml Behringwerke antivenom normal clotting resulted in only 18 out of 23 patients. Local tissue swelling was similar in both groups, but local necrosis occurred in three patients treated with Behringwerke antivenom and in none given S.A.I.M.R. antivenom.


Letter: Agoraphobia.

Letter: Agoraphobia.


NADP-dependent isocitrate dehydrogenase from rat brain cytosol.


Studies of the metabolism of asialotransferrins: relationship between the carbohydrate composition of bovine, canine, and porcine asialotransferrins and their metabolic behavior in the rabbit.


Occurrence of c-type cytochrome in Mycobacterium lepraemurium.


Objective rhinomanometric clinical testing of an antihistamine (clemastine) combined with adrenergic substance (phenylpropanolamine).


Induction of rhythmic activity by harmaline.


Medical treatment of Crohn's disease.

Medical treatment of Crohn's disease.


Glutamate dehydrogenase, glutamic acid decarboxylase, and GABA amino transferase in epileptic mouse cortex.


Medical management of ulcerative colitis.


Etiology of breast cancer. III. Opportunities for prevention. Breast cancer, or its effects, may be preventable. Childbearing at an early age will confer some protection. Until there are other methods of primary prevention the physician must concentrate on secondary prevention, including screening. In presenting risk factors as criteria for screening we have attempted to make rational the use of screening technology. We should not easily accept screening for breast cancer as of proved value. Rather we must encourage clinical trials of various screening methods. In the meantime, while we engage in a moderate amount of screening we do so under the Scottish verdict of "not proven".


Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA.


Short-term effects of free fatty acids on the regulation of fatty acid biosynthesis in Ehrlich ascites tumor cells.


Structural studies of capsular polysaccharide of type XII Diplococcus pneumoniae.


Ocelli of hydromedusae.

Ocelli of hydromedusae.


Studies on the metabolism of D- and L-isomers of 3,4-dihydroxyphenylalanine (DOPA). VI. Metabolism of D-DOPA in rat kidney.


Effect of cis-diamminedichloroplatinum (NSC-119875) on the allograft reaction in mice.


Simulated multiday underwater habitation in hyperbaric helium-oxygen environment.


Pharmacological characterization of adrenergic alpha and beta receptors mediating the vasomotor responses of cerebral arteries in vitro.


The relationship of leucocyte adenyl cyclase activity and airways response to beta blockade and allergen challenge in extrinsic asthma.


Congenital and acquired disturbances of histidine metabolism.


Specific beta adrenergic blockade by practolol.


Differential diagnosis in intersex conditions.


Surgical construction of the male external genitalia.


Reduced serum somatomedin activity in patients with chronic liver disease.


Nutrition and metabolism following thermal injury.


Editorial. Drug imprinting.

Editorial. Drug imprinting.


Diet patterns and dental caries in third grade U. S. children.


ECSI-a new index for evaluating caries progression.


Assessment of gingival change using color photography.


Dental injuries in Copenhagen schoolchildren, school years 1967-1972.


Nitrogen excretion by the fresh water pulmonate snail, Lymnaea stagnalis jugularis Say.


Free amino acids in fish brain: normal levels and changes upon exposure to high ammonia concentrations in vivo, and upon incubation of brain slices.


Electrocardiographic characteristics of four anuran amphibia.


Absorption of sugars in the gill of the Japanese oyster, Crassostrea gigas.


Evidence for multiple inhibitory innervation of horseshoe crab muscles.


The relation of blood hemoglobin concentration to body size in the toad Bufo boreas.


Changes in serum osmotic and ionic concentration in landlocked Petromyzon marinus.


Intracellular pH and electrolyte concentration in the uterine wall of the fowl in relation to shell formation and dietary minerals.


Variations of the level of the digestive enzymes during the intermolt cycle of Palaemon serratus: influence of the season and effect of the eyestalk ablation.


Tissue and plasma electrolyte levels in the awake state during the year, in summer cold exposure and during arousal from hibernation in the hedgehog (Erinaceus europaeus).


Growth and development of temperature regulation in nestling cattle egrets.


Metabolic-temperature responses fo the copepod Euterpina acutifrons (Dana) from Brazil.


42K efflux, EKG and tension in isolated perfused hearts of white-footed mice.


Biochemical and cytochemical investigations of (Na+-K+)-ATPase in the crayfish kidney.


Observations on K+-stimulated p-nitrophenylphosphatase in the lachrymal gland of Malaclemys terrapin, during adaptation to salt and fresh water.


Variations in serum constituents of the blue crab, Callinectes sapidus: major cations.


Evidence of a sclerotized collagen from the skeleton of a gorgonian coral.


A pilot investigation of clinical effects of PM-33, a new anti-anxiety agent.


Pilot open-label study on U-31,889 in anxious in-patients.


Clozapine (Leponex) compared with chlorpromazine: a double-blind evaluation of pharmacological and clinical properties.


Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.


The ballooning posterior leaflet syndrome: Minnesota Multiphasic Personality Inventory profiles in symptomatic and asymptomatic groups.


Sex-related differences in drug metabolism.


THe localization, metabolism and effects of drugs and toxicants in lung.


Metabolism of testosterone and 5alpha-dihydrotestosterone in vitro by the seminiferous tubules of the mature rat.


Habitability in long-duration space missions.


Distribution of 3H- and 14C-labelled potential neurotransmitters on a discontinuous density gradient after uptake into rat cerebral cortex slices.


Effect of B6 deficiency on hepatoma 7794A growth rate: activities of tyrosine transaminase and serine dehydratase before and after induction by hydrocortisone.


Cellular events in tolerance. IV. The effect of a graft-versus-host reaction and endotoxin on hapten- and carrier-specific tolerance.


Induction of B cell tolerance to polysaccharides by exhaustive immunization and during immunosuppression with cyclophosphamide.


Resistance to hydrocortisone conferred upon thymocytes by a thymic humoral factor.


Phosphorylcholine-bearing components in homogenates of nematodes.


Studies on the pharmacology of skeletal muscle in culture: specificity of receptors.


The anticonvulsant action of the carbonic anhydrase inhibitor methazolamide: possible involvement of a noradrenergic mechanism.


Paradoxical vagal tachycardia in ganglion-blocked anesthetized dogs.


Centrally mediated bradycardia and hypotension induced by narcotic analgesics: dextromoramide and fentanyl.


Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine.


On the synthesis of glutamine before and after fertilization of the sea urchin, Strongylocentrotus purpuratus.


Uptake of certain possible neurotransmitters into retinal neurons of some mammals.


Purification and properties of malic dehydrogenase from Trichomonas gallinae.


A complex formation of the adrenal iron-sulfur protein (adrenodoxin) with cytochrome c and the decomposition of the iron-sulfur center.


Photochemical activities of chloroplasts treated with diazonium-1,2,4-triazole.


8,9-Dihydro-8,9-dihydroxybenz(a)anthracene 10,11-oxide: a new type of polycyclic aromatic hydrocarbon metabolite.


Purification and partial characterisation of 4-aminobutyrate 2-ketoglutarate transaminase from human brain.


An energy independent interaction of ATP with the mitochondrial NADH-dehydrogenase: competitive inhibition.


NAD- and NADP-malic enzymes in spermatozoa of mammals and fish.


Synthesis of ferritin in cultured hepatoma cells.


A possible mechanism for the halothane-induced inhibition of mitochondrial respiration: binding of endogenous calcium to NADH dehydrogenase.


Intermediary metabolism of the lung.

Intermediary metabolism of the lung.


Effect of psychoactive drugs on the motility of human spermatozoa.


Lichen planus pigmentosus.

Lichen planus pigmentosus.


The effect of some psychoactive drugs and metallic salts on the motility of rabbit spermatozoa.


The influence of tissue polarity on nematocyte migration in Hydra attenuata.


1924-1974: hospitals through the looking glass.


Death of patient urges better oxygen management.


The strike weapon.

The strike weapon.


Medical malpractice: plaintiff's counsel speaks.


Innovations in health care systems research.


Shared computer services: the Saskatchewan experience.


Organizational environment and work satisfaction.


A pioneer program for the emergency nurse.


Menu costing: a curb for inflation.

Menu costing: a curb for inflation.


[Editorial: Dimensions marks 50 years].

[Editorial: Dimensions marks 50 years].


Creating a future for nursing home services.


Psychiatric needs of geriatric patients.


[President's editorial: A milestone for the CHA].


The core committee: a management model for public health units.


[Guest editorial: The diseases of choice are in our hands].


Regionalization and the small hospital: are trustees losing by default?


The hospital inquest: lessons in death.

The hospital inquest: lessons in death.


The widening gap in labor relations goals.


Hepatitis deaths provide more questions than answers.


Focus on productivity in food service.

Focus on productivity in food service.


Renovation of physical medicine facilites: how to rehabilitate your rehab unit.


The perinatal intensive care unit: help for high risk infants.


[Editorial: Hospitals must not be the scapegoat].


An anesthetist's viewpoint: do pre-operative visits alleviate anxiety?


New handbook from B.C.: guideline standards for the OR nurse.


Conflict of interest on hospital boards.


The psychiatric team: a group approach to patient care.


Evaluation by audit: a check system for nursing care.


Ontario establishes hospital inquiry commission.


The role of production in food service costs.


Cost control in the hospital lab.

Cost control in the hospital lab.


The challenge of respiratory infections.


Sterilization techniques for respiratory equipment.


Preventive maintenance reduces x-ray equipment costs.


[Editorial: The constraints of morality].


Tobacco addiction: a cloud over hospitals.


Retention of medical records.

Retention of medical records.


Marker discrimination and mutagen-induced alterations in pneumococcal transformation. Nitrous acid-induced and hydroxylamine-induced chemical alterations in transforming DNA result in the loss of biological activity and in mutagenesis. The function responsible for the discrimination between high efficiency and low efficiency markers in pneumococcal transformation, and for the elimination of a substantial fraction of spontaneously occurring mutational events, does not appear to act on integrated DNA carrying these chemical alterations. The chemical modifications result in mutations that are evident among bacteria transformed with the treated DNA. Fusidic acid-resistant mutants isolated in this way have been shown to be predominantly of the low efficiency class. We have previously reported that most mutations of spontaneous origin occurring in this locus are of the high efficiency class, and have suggested that discrimination results from the elimination of specific classes of base pair mismatches that occur as intermediates in transformation. It would appear that the base pair mismatches most effectively eliminated in the discriminating strain of pneumococcus are those of the A:C and G:T type and that the immediate product of transformation with mutagenized DNA involves intermediates that are not recognized as A:C or G:T by the discrimination system.


Cyclic nucleotides and their role in gastrointestinal secretion.


Action of thiamine on protein and nucleic acid metabolism, III. Transketolase activity of Lactobacillus viridescens during thiamine starvation.


The formation of gamma-aminobutyrate in liver cell nuclei.


Metabolism of 2-hydroxyoestrogen methyl ethers in the rat liver in vitro.


Editorial: Peptic ulcer: diet or drugs?

Editorial: Peptic ulcer: diet or drugs?


Paramedical education.

Paramedical education.


Approved schools of nursing.

Approved schools of nursing.


Illinois Government Agencies.

Illinois Government Agencies.


Poison control centers in Illinois.

Poison control centers in Illinois.


Trauma Centers in Illinois.

Trauma Centers in Illinois.


Licensed clinical laboratories.

Licensed clinical laboratories.


Approved renal dialysis facilities, centers and directors, Illinois Department of Public Health. Division of Disease Control.


Artificial kidneys for acute poisoning cases.


Medical legal information.

Medical legal information.


Repeal of the Aurora brand interchange agreement.


Surgical grand rounds. Stroke in a 19 year-old man.


Computerized axial tomography with the EMI-scanner at Loyola University Medical Center.


Ekg of the month.

Ekg of the month.


Transthoracic needle biopsy.

Transthoracic needle biopsy.


Objective arterial venous examination in peripheral vascular disease.


Boutonniére deformity.

Boutonniére deformity.


A clinical evaluation of simple renal cysts.


Can essential hypertension be approached prophylactically?


Surgical grand rounds: splenectomy.

Surgical grand rounds: splenectomy.


Editorials: Teenage psychological problems.


Perinatal health in Illinois.

Perinatal health in Illinois.


Editorial: Sue me, sue me!

Editorial: Sue me, sue me!


Editorial: Doctors save lives by telephone.


The suicide assessment team (SAT) in a general hospital.


The education of an intern.

The education of an intern.


Therapeutic efficacy of mebrophenhydramine in some pruritic dermatoses.


Reduced nicotinamide adenine dinucleotide and reduced nicotinamide adenine dinucleotide phosphate diaphorase activity in human polymorphonuclear leukocytes. Total reduced nicotinamide adenine dinucleotide (NADH) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase activities were examined in human neutrophils. Approximately two-thirds of each enzyme activity was located in the granule fraction with the remainder in the soluble. The activities in a 27,000 x g supernatant from a sonic extract of human polymorphonuclear leukocytes were characterized. Both NADH and NADPH diaphorase were insensitive to cyanide and azide and showed greater activity at acid pH. K(m) values for nitroblue tetrazolium were not markedly different (33 muM with NADH and 12 muM with NADPH), but there was a 40-fold difference in K(m) for the reduced pyridine nucleotides (10 muM with NADH and 400 muM for NADPH). Since the intracellular concentration of both nucleotides is estimated to be about 50 muM, it is much more likely, from a kinetic argument, that the respiratory burst of phagocytosis is intiated by the oxidation of NADH rather than of NADPH.


An assessment of oral disease among primary school children in Lebanon. I. Assessment of dental caries.


Effects of anti-anaphylactic drugs upon passive cutaneous anaphylaxis mediated by graded doses of reaginic or non-reaginic antibodies in rats.


Stimulatory and inhibitory effects of graft-versus-host reactions on contact sensitivity in mice.


Graft-versus-host reactions and activation of host antibody-forming cells induced by in vitro stimulated syngeneic lymphocytes.


Suppression of cellular immunity in rats and mice by maternal treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin.


Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. III. Inhibition of worm expulsion from guinea pigs by treatment with reserpine.


Hypotensive action of ICI66.082, a new beta-adrenergic blocking agent.


Multidrug use: supplementary perspectives.


The college opiate user.

The college opiate user.


Personality traits and attitudes and their relationship to student drug using behavior.


Patterns of drug abuse.

Patterns of drug abuse.


Thymus-dependency of the immune response of mice to a primary infection with the nematode Trichuris muris.


The peripheral and central role of the catecholamines in the mechanisms of anxiety.


Caries experience in Arab and Jewish urban populations: a comparative study of schoolchildren in East and West Jerusalem.


Transport of sugars and amino acids in bacteria. X. Sources of energy and energy coupling reactions of the active transport systems for isoleucine and proline in E. coli.


Endo-beta-N-acetylglucosaminidases acting on the carbohydrate moieties of glycoproteins. The differential specificities of the enzymes from Streptomyces griseus and Diplococcus pneumoniae.


Additional evidence for the liberation of substrate alpha-hydrogen prior to reduction of the coenzyme in D-amino acid oxidase reaction.


Studies on receptor-mediated activation of adenylyl cyclases. IV. Characteristics of the adrenergic receptor coupled to myocardial adenylyl cyclase: stereospecificity for ligands and determination of apparent affinity constants for beta-blockers.


Characteristics of ethanol and acetaldehyde oxidation on flavin and pyridine nucleotide fluorescence changes in perfused rat liver.


Studies on the microsomal electron-transport system of anaerobically grown yeast. I. Intracellular localization and characterization.


Stabilizing injured teeth with direct bonding.


Role of expectancy manipulation in systematic desensitization.


A controlled comparison of the effects of diphenylhydantoin and placebo on mood and psychomotor functioning in normal volunteers.


Application of Faschingbauer's abbreviated MMPI to psychiatric inpatients.


Systematic desensitization of test anxiety: a comparison of group and individual treatment.


A 166-item written short form of the group MMPI: The FAM.


Negro versus Caucasian psychological test performance revisited.


Transfer, behavioral improvement, and anxiety reduction in systematic desensitization.


Personality differences between fee-paying and non-fee-paying patients seen for psychological testing.


Comparative validity of strategies and indices for differential diagnosis of depressive states from other psychiatric conditions using the MMPI.


Comparison of the Minnesota multiphasic personality inventory and Mini-Mult with drug users.


Watch your deductions!

Watch your deductions!


A contribution to the study of immunological reactivity of the organism in agricultural workers.


Clonal nature of the immune response to phosphorylcholine. III. Species-specific binding characteristics of rodent anti-phosphorylcholine antibodies.


Influence of cyclophosphamide on the delayed hypersensitivity in the mouse after immunization with histocompatibility antigen.


Regulatory role of T cells in IgG antibody formation and immune memory to type III Pneumococcal polysaccharide.


Urticaria and arthralgias as manifestations of necrotizing angiitis (vasculitis).


Strength mechanisms of dental solder joints.


Drug therapy reviews: rational use of psychotropic drugs. III. Major tranquilizers.


Scanning electron microscopy of mosquitoes. Part III. The egg surface structure of 5 species from Taiwan and 2 species from Indonesia.


Changes in carbohydrate substrates, amino acids and ammonia in the brain during insulin-induced hypoglycemia.


Studies on the neurogenic short-term control of adrenomedullary hormone synthesis.


Development of an expression which relates the excitable state of the brain to the level of GAD activity and GABA content, with particular reference to the action of hydrazine and its derivatives.


The effect of gamma-aminobutyric acid on brain mitochondrial ATP synthesis.


Effects of the control of plaque on the progression of dental caries: results after 19 months.


Properties of brain L-glutamate decarboxylase: inhibition studies.


Effect of neurotropic agents on total pyridoxal phosphate and on the activity of the decarboxylose of aromatic amino acids as well as of other pyridoxal phosphate-dependent enzymes in rat brains.


A study of selected catecholamine metabolizing enzymes: a comparison of depressive suicides and alcoholic suicides with controls.


Uptake and release of possible false transmitter amino acids by rat brain tissue.


Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in the individual rat hypothalamic nuclei.


Effects of enucleation and intra-ocular colchicine on the amino acids of frog optic tectum.


Fibre hybrids in type groups. An investigation of human muscle biopsies.


Congenital rod disease. Further evidence of innervational abnormalities as the basis for the clinicopathologic features.


Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis.


The meaning of work--1974.

The meaning of work--1974.


New intermediate hosts of the digenetic trematodes, Monorcheides cumingiae Martin (1938) and Neopechona pyriforme (Linton, 1900).


Do MMPI psychopathic deviancy scores reflect psychopathic deviancy or just deviancy?


The response of young diabetics to periodontal treatment.


Clinical psychological testing in Tourette's syndrome.


Decalin analogs of phenethylamines as inhibitors of amine uptake by rabbit platelets I: uptake and distribution of histamine.


Antitumor activity and cardiac stimulatory effects of constituents of Anthopleura elegantissima.


Drug release from hydroxypropyl cellulose-polyvinyl acetate films.


Stimulus control of hexobarbital narcosis and metabolism in mice.


Isolation and partial purification of hemolytic toxin from sea anemone, Stoichactis helianthus.


Effect of dibutyryl cyclic adenosine monophosphate on 14C-dopamine biosynthesis in rat brain striatal slices.


Beta receptor blocking and antiarrhythmic properties of tolamolol.


Utilization of simulated patients to teach the routine pelvic examination.


A guide to drug therapy in renal failure.


General medical care identification and analysis of alternative approaches.


Leadership development at the clinical unit level.


National nutrition policy conference: an end to apathy?


Otolaryngology in Australia through a retrospectoscope.


A multicentre trial of perhexiline maleate, beta-blocker and placebo in angina pectoris.


Editorial: Pneumococcal typing and sensitivity.


Editorial: Epidemic polyarthritis.

Editorial: Epidemic polyarthritis.


Type distribution and antibiotic sensitivity of Diplococcus pneumoniae. A five-year study in Sydney.


Cephradine--a new oral cephalosporin antibiotic.


A television fluorometer for monitoring oxidative metabolism in intact tissue.


Enzymology at sub-zero temperatures.

Enzymology at sub-zero temperatures.


Catecholamine synthetic enzymes of spontaneously hypertensive rats and microbial hypotensive products.


The development of our current concepts of biological oxidations.


Mechanisms and physiological roles of fatty acid chain elongation in microsomes and mitochondria.


Mutagenic activation of dimethylnitrosamine and diethyl-nitrosamine in the host-mediated assay and the microsomal system.


The formation and kinetics of reactive drug metabolites in mammals.


Alternate host for mosquito parasite Coelomomyces.


Isolation of photoreceptor and conventional nerve terminals by subcellular fractionation of rabbit retina.


Light-evoked release of glycine from the retina.


Acetylcholine as an excitatory neuromuscular transmitter in the stomatogastric system of the lobster.


Glutamate metabolism in the frog retina.


Temperature-dependent interconversion of histamine H1 and H2 receptors in guinea pig ileum.


How selective is high affinity uptake of GABA into inhibitory nerve terminals?


In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens.


Syndrome of ankylosis, facial anomalies, and pulmonary hypoplasia.


The coenzyme-binding domains of glutamate dehydrogenases.


Effect of histamine, pentagastrin and theophylline on the production of cyclic AMP in isolated gastric tissue of the guinea pig.


Beta-adrenolytic, antiarrhythmic and local anaesthetic effects of phenylephrine.


Dissociation between amino-oxyacetic acid-induced depression of spinal reflexes and the rise in cord GABA levels.


Modification of the receptor component of adenylate cyclase in the rat brain by phenothiazine derivatives.


Work, society, and health. Identifying a worldwide resource for nursing education.


Work, society, and health. Introductory remarks: the Distributive Nursing Project.


Chronic diarrhea in childhood: a new look at an old problem.


Persistent systemic hypertension in infants and children.


Vascular nephropathies with acute renal failure.


Arteritis with impaired renal function.

Arteritis with impaired renal function.


Blood coagulation and renal disease.

Blood coagulation and renal disease.


Prevalence and management of hypertension in a general population sample of Swedish men.


Conformational changes induced in dihydrofolate reductase by folates, pyridine nucleotide coenzymes, and methotrexate. Dihydrofolate reductase (EC 1.5.1.3; 5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase) from antifolate-resistant Lactobacillus casei has been isolated in pure form and examined in solution by high resolution proton magnetic resonance spectroscopy. The 220 MHz proton magnetic resonance spectrum of this small enzyme (about 15,000 daltons) consists of several distinct resonance peaks that provide a sensitive nonperturbing probe of its conformational state. Comparison of catalytically active enzyme with preparations denatured in 6 M urea demonstrates dramatically the overall contribution of secondary and tertiary structure to its proton magnetic resonance spectra. More subtle differences existing among several catalytically active enzyme forms may also be readily differentiated by proton magnetic resonance spectroscopy, e.g., the spectra of the ligand-free enzyme and forms containing stoichiometric amounts of tightly bound folate and dihydrofolate, each obtained separately by affinity chromatography, are easily identified. Addition of ligands to these spectroscopically distinct forms may induce changes in their proton magnetic resonance spectra. For example, addition of equimolar dihydrofolate to the apoenzyme converts its relatively featureless aromatic proton magnetic resonance spectrum to one indistinguishable from that of the original enzyme-dihydrofolate binary complex obtained chromatographically. Interaction of the pyridine nucleotide coenzymes NADP(+) or NADPH or of the antifolate Methotrexate with apoenzyme induces additional distinct spectral changes. Enzyme-NADPH and enzyme-Methotrexate binary complexes, which have different aromatic region proton magnetic resonance spectra, are converted to ternary complexes having quite similar spectra by addition of Methotrexate and NADPH, respectively, thus suggesting that an ordered addition of ligands is not required.


Cyclic AMP-mediated induction of the cyclic AMP phosphodiesterase of C-6 glioma cells. Long-term regulation of the cyclic nucleotide phosphodiesterase of the C-6 rat glioma cell line has been studied. Both the low K(m) and high K(m) activities can be induced by elevation of intracellular cyclic AMP levels following either dibutyryl cyclic AMP or norepinephrine treatment of the cells. The enzymes are maximally induced by 3-4 hr. The presence of either cycloheximide or actinomycin D prevents induction by either dibutyryl cyclic AMP or norepinephrine. Evidence is presented that the norepinephrine effect is mediated by the beta-catecholamine receptor. The increased phosphodiesterase activity causes a partial refractoriness to a second challenge with norepinephrine, which can be overcome by blockade of the induction with cycloheximide. The results suggest that just as short-term regulation of cyclic AMP levels occurs via changes in the rates of synthesis or degradation, long-term alterations of the system may also involve either the adenylate cyclase or the phosphodiesterase.


Enhancement of tumor growth by graft-versus-host reaction. A graft-versus-host reaction was induced in (BALB/c x C5 7BL/6)F(1) mice by intravenous injection of BALB/c spleen cells. Six days later, the mice received subcutaneous grafts of a chemically induced BALB/c sarcoma. The growth of the tumor grafts was accelerated.


Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of gamma-glutamyl transpeptidase by maleate; identity of a rat kidney maleate-stimulated glutaminase and gamma-glutamyl transpeptidase. gamma-Glutamyl transpeptidase catalyzes transfer of the gamma-glutamyl moiety of glutathione (and other gamma-glutamyl compounds) to amino acid and peptide acceptors; this reaction probably involves (a) formation of a gamma-glutamyl enzyme and (b) reaction of the gamma-glutamyl-enzyme with an acceptor. Maleate decreases the latter reaction and markedly increases hydrolysis of the gamma-glutamyl donor, apparently by affecting the enzyme so as to facilitate reaction of the gammaglutamyl enzyme with water. Transpeptidase catalyzes gamma-glutamyl hydroxamate formation from many gamma-glutamyl compounds and hydroxylamine; this reaction is stimulated 4- to 5-fold by maleate. Glutamine, a poor substrate for transpeptidation as compared to glutathione, is slowly hydrolyzed and converted to gamma-glutamyl-glutamine by the transpeptidase; in the presence of maleate, hydrolysis of glutamine is markedly (>10-fold) increased, as is also its conversion to gamma-glutamyl hydroxamate in the presence of hydroxylamine. The findings suggest that the previously described "maleate-stimulated phosphate-independent glutaminase" is a catalytic function of gamma-glutamyl transpeptidase. Transpeptidase-catalyzed glutaminase activity may play a role in renal ammoniagenesis. The ability of maleate to decrease transpeptidation of gamma-glutamyl compounds (and to increase their hydrolysis to glutamate), when considered in the light of earlier findings that treatment of animals with maleate produces aminoaciduria, is consistent with function of transpeptidase and the gamma-glutamyl cycle in amino-acid transport.


Synaptic connections made by horizontal cells within the outer plexiform layer of the retina of the cat and the rabbit.