Antigens in the spleen: localization of labelled antigen in the spleen of normal rabbits and rabbits preimmunized with a non related antigen.


Antigenic heterogeneity of J chain from human IgM.


Immunoglobulin classes of human antitoxin after tetanus vaccination studied by immunofluorescence with agarose bound tetanus toxoid.


More sensitive quantitation of low level serum IgE and alpha1-fetoprotein by single radial immunodiffusion using radioiodine labeled IgE or alpha1-fetoprotein as marker.


Histocompatibility antigens of patients with rheumatoid arthritis.


Antiepithelial antibodies in the serum of patients with benign and malignant diseases of the prostate.


Immunoglobulin receptors on "T" lymphocyte surface.


Antigenic correlations between brain and thymus. III. Reciprocal blocking of antigenic determinants on mouse brain and thymocytes by anti-mouse-brain- and anti-thy-1.2 sera.


The unresponsiveness of wistar rats to bovine gamma globulins.


Concurrent comparison of an unsupervised daily oral regimen of thiacetazone plus isoniazid and a fully supervised twice-weekly regimen of streptomycin plus isoniazid in the domiciliary treatment of pulmonary tuberculosis--a co-operative investigation.


Radioimmunoassay and saturation analysis. Tumor-associated antigens.


Urinary and biliary metabolites of 17alpha-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione in the rabbit.


Effect of serum alpha2-macroglobulin on the trypsin-soybean trypsin inhibitor complex.


Antibody reactions to virus-specific early antigens (EA) in patients with cytomegalovirus (CMV) infection.


A serum inhibitor of the heterophile antibody in infectious mononucleosis.


Liver-specific antigens of different species. II. Localization of a membrane antigen at cell surface of isolated hepatocytes.


Lymphocytes in rheumatoid arthritis. II. Quantitative binding of phytomitogens.


Rabbit b4 light chain fragments bearing isotypic and allotypic specificities.


Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice.


Heterologous specific antiserum for identification of human T lymphocytes.


Cryoglobulins in acute and chronic liver diseases.


An antibody to isogeneic fibroblasts in the serum of diseased NZB mice.


Cross-reactivity of T-cell 'helper' function.


The macrophage electrophoretic mobility (MEM) test for malignant disease. Further clinical investigations and studies on macrophage slowing factors.


Amniotic fluid concentrations of alpha-fetoprotein (AFP) in early normal pregnancy, and pregnancy complicated by neural tube defects. A review of 18 months experience. Amniotic fluid concentrations of alpha-fetoprotein (AFP) in early normal pregnancy and pregnancy complicated by neural tube defects were investigated. The normal range of AFP values was determined from 163 samples obtained at 14-20 weeks of  pregnancy.  The relationship between AFP level and gestational age was represented by a linear regression (p less than .001).  Regression lines for males and females differed significantly in position (p less than .01) but not in slope, the line for males 2.7 mcg/ml higher than that for females. No correlation was seen between maternal age and AFP level. 50 ''at  risk'' cases, in whom there has been a history of previous anencephaly or spina bifida, were included in the noraml values. 6 of these patients had amniotic fluid AFP values outside the normal range and in 5 of the 6 cases, ultrasound  examination of the fetus confirmed the diagnosis of an anencephalic type lesion and so termination was undertaken, All 5 fetuses had severe neural tube defects. The 6th fetus revealed an intact neural tube but clear-cut evidence of growth  retardation and the placenta was small and infarcted.


The presence of alpha-amino-beta, gamma-dihydroxybutyric acid in hydrolysates of actinomycin Z1.


Induction of colicin E1 synthesis by neocarzinostatin and bleomycin.


Total synthesis of streptomycin.

Total synthesis of streptomycin.


Alpha fetoprotein: Physiology and pathology during pregnancy and application to antenatal diagnosis.


Practical clinical aspects of RH-prophylaxis.


Medical illustration in the new Health Services. 2. White papers, green papers, and grey books.


A role for medical illustration in developing countries.


Interaction of poly i:c with the cell membrane in trichomonas vaginalis.


Phantom sync-pulsing of audio tapes.

Phantom sync-pulsing of audio tapes.


The Self-Instructional Materials Project, National Health Sciences Consortium.


Teaching basic pharmacology to medical students. An experimental self-instructional approach.


Teacher participation in media centre development.


Aspects of tolerance to RNA in different strains of mice.


An inexpensive "splitter box" for facilitating multiple simultaneous slide projections.


Muscle relaxants -- their road towards perfection.


Cerebral microcirculation: studies by fluorescein angiography and local cerebral blood flow measurements by radioisotopes.


Fundoscopy of the retinal nerve fiber layer in neurosurgical practice.


Stereotactic thalamotomy and L-dopa induced involuntary movement in Parkinsonism.


The role of cyclic 3', 5'-AMP on trauma-induced alteration of energy metabolism in cerebral cortex in vivo.


Fine structure of human epileptogenic foci--preliminary report.


Prisons, shelters, and homeless men.

Prisons, shelters, and homeless men.


Liver studies in the thorotrast patients - laboratory and clinical findings (study of 175 cases).


Recent observations regarding retinoblastoma. II. An enxyme study of retinoblastoma.


In vivo bound immunoglobulins in the human prostate--their identification and possible significance.


Gene amplification in cell-free systems.


In vitro demonstration of cell-mediated immunity against human renal carcinoma assessed by the leukocyte migration assay.


Aedes aegypti surveillance and control in the South Pacific.


Polarization-optical study of the ultrastructure of the ciliata Kahlia acrobates (Horváth).


The mesangial cell in glomerulonephritis.


The pathogenetic role of the coagulation process in glomerular diseases of immunologic origin. The experimental and clinical observations analyzed in this review suggest that the deposition of fibrin within glomeruli is an important pathogenic mechanism in the series of events leading to progressive destruction of glomerular capillaries. Neither the causal factors nor the consequences of this type of reaction are peculiar to the glomerulus. Fibrin deposits can occur in any injured blood vessel and, if not rapidly dealt with by fibrinolysis, will lead to endothelial changes and the development of organizing thrombi. It seems that glomerular capillaries are especially vulnerable; there are several reasons for this. First, some immunologic reactions are triggered within the glomeruli and thus produce a local inflammatory response, leading to fibrin deposition. Secondly, the glomerular filtration function allows a progressive local accumulation of potentially damaging particles, such as circulating fibrinogen derivatives (formed during generalized intravascular clotting), or phlogistic immune complexes (as a result of systemic antigen-antibody interaction); these too cause local injury and fibrin deposition. Finally, the glomerular obliteration resulting from the organization of such fibrin deposits leads to irreversible damage and so has more serious implications for the patient than if the lesions occurred elsewhere, where the formation of functionally useful new capillaries is often possible. It seems reasonable to propose, therefore, that the use of anticoagulant may be natural therapy in cases with the risk of rapid, massive, and continuous fibrin accumulation in glomeruli, where glomerular sclerosis and irreversible renal failure are likely.


Serum IgE in immune deficiency disorders.


Immunochemical studies of infectious mononucleosis. III. Isolation and characterization of heterophile antibodies.


Effect of disodium cromoglycate on antigen-evoked histamine release from human skin.


Preliminary studies on the synthesis of alpha2-macroglobulin by human lymphocytes in vitro.


Effect of continuous low dosage (0.5 mg.) chlormadinone acetate on the genital tract of women.


Studies with LH-RF (Gn-RF) in cattle.

Studies with LH-RF (Gn-RF) in cattle.


A primer to histotechnology.

A primer to histotechnology.


Histamine and serotonin release from isolated rat peritoneal mast cells by arginine rich nuclear proteins.


Innovate teaching techniques.

Innovate teaching techniques.


Some effects of dibutyryl cyclic adenosine monophosphate (DBcAMP) on rabbit bone marrow cells in culture: cell clumping and cholinesterase production.


Effects of steroids upon the liver ultrastructure.


The contribution of some histochemical methods to the diagnosis of breast cancer.


Lipotriad. A double-blind clinical trial.


Systemic effects of eye drops.

Systemic effects of eye drops.


The value of intensive care.

The value of intensive care.


The treatment of noncycling mares by oral application of chlormadinone acetate (CAP).


Preparation of aminoazo dye induced rat hepatoma membrane fractions retaining tumour specific antigen. Membrane fractions were isolated from homogenates of an aminoazo dye induced rat hepatoma (hepatoma D23) by sucrose density gradient centrifugation in zonal rotors. The membrane fractions retained tumour specific antigenic determinants and exhibited an increased antigenic activity over other subcellular membrane fractions, as defined by their capacity to quantitatively neutralize the membrane immunofluorescence staining of viable hepatoma D23 cells by antibody in tumour immune serum. In contrast, no antigenic activity was found to be associated with purified hepatoma D23 nuclei or nuclear membranes as evaluated by the in vitro antigen assay.The two methods described for the isolation of hepatoma D23 membranes have been developed for the large scale fractionation of tumour homogenates in order that further studies upon the nature and immunogenicity of membrane associated tumour specific antigens may be resolved using defined membrane preparations of increased antigenic activity.


The effect of bleomycin and its combined effect with radiation on murine squamous carcinoma treated in vivo. Many previous reports testify to the effectiveness of bleomycin as a drug for the clinical treatment of squamous carcinomata, and some radiotherapists have considered the possibility that an improved therapeutic ratio might be obtained by combined treatment with bleomycin and radiation. This consideration has been stimulated by recent reports of the effects of combined treatment with bleomycin using mammalian cells in vitro. Experiments are described here in which a murine squamous carcinoma has been used to obtain a survival curve for cells of tumours treated in vivo with single doses of bleomycin alone or in combination with radiation given before or after the drug. The survival curve for drug alone was a multicomponent curve with D(0) values of 0·1, 0·75 and 2·7 mg/kg. However, the results of the experiments with combined treatment showed no evidence of potentiation.


The sensitivity to bleomycin of a solid mouse tumour at different stages of growth.


Passive sensitization of guinea-pig skin in vitro for the antigen-induced release of anaphylactic mediators.


Respiratory mast cells and basophiloid cells. I. Evidence that they are secreted into the bronchial lumen, morphology, degranulation and histamine release.


The relationship of the P-K titre to the serum IgE level in patients with leprosy.


Homogeneous immunoglobulins in sera of rhesus monkeys after lethal irradiation and bone marrow transplantation.


Shared antigenic determinants between human brain and human T-cell line.


Spontaneous cardiomyopathies in Chacma baboons.


Haemodynamic basis for pericardiotomy as palliative treatment of idiopathic endomyocardiopathy.


Direct approach to the enumeration of structural proteins of the large ribosomal subunit of rat liver.


Studies on proteins of animal ribosomes. XVIII. Reaction of ribosomes and ribosomal proteins with antibodies against ribosomal proteins.


Morphology of the ribosomal 30S subparticle according to electron microscopic data.


Agar gel electrophoresis of unconcentrated cerebrospinal fluid: the degenerative type. Five to 10 mul of 196 cerebrospinal fluid samples were subjected to agar gel electrophoresis without previous concentration. No "degenerative" pattern was found to be correlated with any clinical diagnosis or group of diagnoses, Repeated freezing and thawing appears to have different effects on the different fractions. The oligoclonica gamma patterns in shown to be demonstrable by this method.


The structure of liver ribosomes.

The structure of liver ribosomes.


Effects of 5-azacytidine on hepatic polyribosomes and maturation of ribosomal RNA.


Auditory discrimination and substitutions concerning the phonemes /s/ /l/ /r/ /rr/ /d/ in the speech disorders of dyslalic children.


Partial isolation of a membrane antigen which induces the formation of antibodies lethal to schistosomes cultured in vitro.


Anaphylactic hyposensitization of rat mast cells in vitro by antigen.


Disturbed relationship of plasma-renin to blood-pressure in hypertension.


Increased bilirubin levels in neonates after induction of labour by intravenous prostaglandin E2 or oxytocin. 4 groups of 30 primigravidas and their infants were studied prospectively.  No patient with rhesus incompatibility was included in the study.  The 4 groups went into labor in the following ways:  1) induced by intravenous oxytocin; 2) induced by intravenous prostagladin (PG)E2; 3) induced by extraamniotic PGE2; and 4) spontaneous labor.  Mean infant bilirubin levels on day 5 were significantly higher (p.005 and p.025 respectively) for the 1st 2 groups than for the spontaneous group.  Levels for the group whose labor was induced with extraamniotic PGE2 infusion were not significantly different from those in the 1st 2 groups or the spontaneous group.  The mean serum-bilirubin level was significantly lower (p.025) after caesarean section than after assisted vaginal delivery.  Serum-bilirubin levels were not affected by previous maternal use of oral contraceptives, maternal smoking, or methods of infant feeding.  Serum bilirubin levels below 10 mg/100 ml. are considered within the normal phsyiological limits during the neonatal period.  Measured by this criteria, 14, 10, 9, and 6 babies in groups 1-4 respectively had abnormally high levels.  The difference between groups 1 and 4 was significant at the p.05 level.  Mean Apgar scores were significantly lower for the babies whose mothers had induced delivery with extraamniotic PGE2 infusion.  These results suggest that the observed hyperbilirubinemia may be due to interruption of pregnancy rather than to any direct drug effect.  There is no evidence to suggest that such high bilirubin levels are harmful to the child in the long run.


Surgery for cardiogenic shock.

Surgery for cardiogenic shock.


Death and coronary attacks in men after giving up cigarette smoking. A report from the Framingham study.


Lymphocytotoxins in primary renal disease.


Skin lesions, angio-oedema, and hypocomplementaemia.


Simultaneous occurrence of soft-tissue sarcoma and parotid-gland tumours: A new syndrome?


Temporary paralysis in childhood after influenza B.


Treatment of parkinsonism with bromocriptine.


An experiment in community mental health care.


Editorial: Rapeseed oil revisited.

Editorial: Rapeseed oil revisited.


Editorial: Fat embolism and hypoxaemia.

Editorial: Fat embolism and hypoxaemia.


Pre-hospital ventricular defibrillation.


Editorial: Training the basic doctor.

Editorial: Training the basic doctor.


Editorial: More from the adverse reactions register.


Editorial: Primary care of mental illness.


Editorial: Out of mind?

Editorial: Out of mind?


Anaemia.

Anaemia.


Urinary-tract infection.

Urinary-tract infection.


Diabetes.

Diabetes.


Sickle-cell disease.

Sickle-cell disease.


Epidemiology of cholera in Italy in 1973.


Neural route of infection in viral diseases of the central nervous system.


Letter: Immunochemical localisation of complement in intestinal mucosa.


Letter: Maternal smoking and immunity.

Letter: Maternal smoking and immunity.


Letter: Screening for hypertension.

Letter: Screening for hypertension.


Letter: Breast cancer and hypertension.

Letter: Breast cancer and hypertension.


Letter: Withdrawal of antihypertensive therapy.


Letter: Cold-sensitive strain of Pseudomonas aeruginosa from urinary-tract infection.


Letter: Bowie and Dick test for autoclaves.


Letter: Skin wrinkling in cystic fibrosis.


Letter: HL-A antigens in asymptomatic chronic HBAg carriers.


Letter:  HL-A antigens in leprosy.

Letter:  HL-A antigens in leprosy.


Letter: Ketamine-induced acidosis, fever, and creatine-kinase rise.


Letter: Prolactin, prostaglandin, and bone pain of metastatic breast cancer.


Letter: Viability of skin flaps.

Letter: Viability of skin flaps.


Letter: Iron and infection in the newborn.


Letter: Identity of cervical dysplasias.


Letter: Outbreak of Salmonella agona in Italy.


Letter: Hepatoblastoma associated with an oral contraceptive.


Letter: Oral contraceptives, plasma-lysolecithin, and platelet aggregation.


Letter: Reappearance of intestinal gas cysts after oxygen treatment.


Letter: "Anti-anti".

Letter: "Anti-anti".


Letter: Human placental lactogen and fetal abnormality in infants of diabetic mothers.


Letter: Twinning and illegitimacy in C.N.S. defects.


Letter: Influenza A in an isolated population in the Amazon.


Letter: Malignant kwashiorkor.

Letter: Malignant kwashiorkor.


Letter: Malnutrition and school progress.


Letter: Duration of breast-feeding.

Letter: Duration of breast-feeding.


Letter: Staphylococcal infection in the newborn.


Letter: Immunocompetence in low-birth-weight infants after intrauterine malnutrition.


Letter: Oral digitalisation.

Letter: Oral digitalisation.


Letter: Agarose and counterimmunoelectrophoresis.


Letter: Abnormal coagulation and trauma.


Letter: Endoscopic liver biopsy.

Letter: Endoscopic liver biopsy.


Letter: Carcinoma of the colon and cholecystectomy.


Letter: Serum-copper in Hodgkin's disease before and after herpes zoster.


Letter: Chemotherapy of Hodgkin's disease.


Letter: Methyl-cholanthrene-induced sarcomata in mice after immunisation with Corynebacterium parvum plus syngeneic subcellular membrane fractions.


Letter: Otitis media due to ampicillin-resistant Haemophilus influenzae.


Letter: Serum-gastrin, vitiligo, and achlorhydric atrophic gastritis.


Letter: Costing equipment for epidurals.


Letter: Muscular dystrophies.

Letter: Muscular dystrophies.


Dillwyn Evans.

Dillwyn Evans.


Mary Broadfoot Walker.

Mary Broadfoot Walker.


Raymond Marcus McKenzie Pratt.

Raymond Marcus McKenzie Pratt.


Roland Anthony Bennett.

Roland Anthony Bennett.


Timothy Stephen Radcliffe.

Timothy Stephen Radcliffe.


Harry Chapman Sinderson.

Harry Chapman Sinderson.


Linkage and rearrangement of genes encoding mouse immunoglobulin heavy chains.


Clinical problems of some bullous dermatoses.


Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells. Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 10(6) thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis.


The autoimmune status in graves' disease.


Antihistamines block radiation-induced taste aversions. When rats are treated with an antihistamine prior to being given sublethal doses of ionizing radiation, the formation of a conditioned saccharin aversion is completely inhibited. A profound aversion could be conditioned with histamine diphosphate as the aversive stimulus. The increase in histamine production after radiation exposure represents the physiological basis of radiation-induced taste aversions.


Effect of sublethal concentrations of the insecticides DDT, Abate and Sevin, applied to 3rd stage larvae of Culex pipiens molestus on certain biological aspects of the mosquito.


Effect of sublethal concentrations of the insecticides DDT, Abate and Sevin applied to 3rd stage larvae of Anopheles pharoensis on malaria cycle in the adult mosquito.


Effect of beta adrenergic blocking on the arrhythmias following coronary ligation in rat.


The complement system and nephritis.

The complement system and nephritis.


Alpha-fetoprotein in the management of high-risk pregnancies.


Management and prevention of erythroblastosis fetalis.


Five-year follow-up of thyrotoxicosis treated with antithyroid drugs.


In vitro studies of cell mediated immunity to human sarcomas.


Filarial infectivity rate of Culex pipiens molestus subjected to sublethal concentrations of insecticides Abate and Sevin and distribution of infective filaria larvae in mosquito body regions.


Glycosaminoglycans and sialoproteins in skin aging.


Clinical and experimental investigations on the effect of cytostatic drugs in psoriasis.


Retrograde axonal transport of horseradish peroxidase in rats forebrain.


Skinning of cestodes of middle and large sizes for whole mounts. Technical note.


Afferents to the rat caudoputamen studied with horseradish peroxidase. An evaluation of a retrograde neuroanatomical research method.


The timing of the earliest motor innervation to the hind limb bud in the Xenopus tadpole.


A microelectrophoretic delivery technique for use with horseradish peroxidase.


The retrograde axonal transport of nerve growth factor. A retrograde axonal transport of nerve growth factor (NGF) from the adrenergic nerve terminals in the mouse iris to the cell bodies of postganglionic sympathetic neurones in the superior cervical ganglion has been demonstrated. After injection of iodinated nerve growth factor (125I-NGF) into the anterior eye-chamber there was a relatively rapid accumulation of radioactivity in the superior cervical ganglia on both injected and non-injected sides, as was the case after subcutaneous injection. However, 4 h after intraocular injection a preferential accumulation of radioactivity became apparent in the superior cervical ganglion on the injected side, and this difference between the ganglia on injected and non-injected sides gradually increased to a maximum at 16 h. Transection of the postganglionic adrenergic fibres as well as the prior intraocular injection of colchicine abolished the preferential accumulation of 125I-NGF in the superior cervical ganglion of the injected side, whereas the destruction of adrenergic nerve terminals by 6-hydroxydopamine did not impair the preferential accumulation. It is concluded that the retrograde axonal transport of NGF, which was estimated to take place at a rate of about 2.5 mm/h, depends on a colchicine-sensitive mechanism as does the orthograde rapid axonal transport. However, the uptake of NGF may not only take place from the nerve terminals but also from the preterminal parts, as has been shown in other studies with horseradish peroxidase. Autoradiographic studies strongly supported the existence of a retrograde transport by showing a clear localization of radioactivity in a small number of neurones in the superior cervical ganglion on the injected side, whereas on the non-injected side there was only a diffuse distribution of radioactivity throughout the ganglion.


The Feulgen-DNA content in human individual metaphasic chromosomes.


A complement fixation test for the detection of alpha-feto-protein in the diagnosis of primary liver cancer.


Biochemical mechanism of resistance to aminoglycosidic antibiotics.


Structures and syntheses of aminoglycoside antibiotics.


Molecular architecture of human chromosomes.


Atmospheric carbon monoxide.

Atmospheric carbon monoxide.


Production of instructional messages for education in the health professions: a role-integrated approach.


Use of television and film in continuing education in the health sciences. A nine year experience.


Visual communication and continuing medical education.


What's available? Is it any good? How do you know?


Delivery of papers at scientific meetings.


Mastery learning, minicourses and multimedia instruction in anatomy.


Arteriovenous hemangioma (arteriovenous shunt). A clinicopathological and histochemical study.


Light and electron microscopic study of Riehl's melanosis. Possible mode of its pigmentary incontinence.


Serum concentrations and antituberculosis activity of thiacetazone.


A study of adverse reactions to high dosage intermittent thiacetazone.


Treatment of isoniazid-resistant pulmonary tuberculosis with ethambutol, rifampicin and capreomycin: a co-operative study in England and Wales.


The sensitivity to thiacetazone of tubercle bacilli isolated from patients with pulmonary tuberculosis in Sri Lanka.


A pilot study of two regimens of intermittent thiacetazone plus isoniazid in the treatment of pulmonary tuberculosis in East Africa.


Notes on the Ziehl-Neelsen staining of sputum.


A controlled clinical trial of the role of thiacetazone-containing regimens in the treatment of pulmonary tuberculosis in Singapore: second report.


Immunoglobulins in liver diseases.

Immunoglobulins in liver diseases.


Potential dilemma: the methods of meeting automotive exhaust emission standards of the clean air act of 1970. This review attempts to provide an overview of the interconnected industrial changes associated with compliance with the exhaust emission standards of the Clean Air Act of 1970. To understand the complex nature of air pollution problems, Federal legislation, and compliance with this legislation requires an understanding of automotive technology, petroleum refining, atmospheric chemistry and physics, economics, and public health. The endeavors of all of these different areas impinge to a greater or lesser extent on the final response to the Clean Air Act which is designed to safeguard public health. This overview begins by examining gasoline refinery practice and gasoline composition. Included in this discussion are average values for trace contaminants in gasoline, and an explanation of the function of the many gasoline additives. Next, exhaust emissions are characterized, average values of exhaust components given, and a summary of important atmospheric air pollution reactions presented. Emission control devices and sulfate emissions from these devices are described. This is followed by a complete discussion of methyl cyclopentadienyl manganese tricarbonyl, a substitute antiknock for tetraethyllead. In the event TEL is legally banned from gasoline, or removed because it poisons the catalytic muffler surface, this manganese antiknock is the most efficaous replacement. In this discussion, the adverse health effects caused by exposure to manganese oxide particulates, the possible exhaust emission products from this additive, are examined in detail. The review concludes with comments on automotive engine and gasoline composition redesign as an approach to automotive air pollution.


The surgical treatment of extracranial arterial occlusion.


Inhibitors of nucleic acid synthesis: biophysical and biochemical aspects.


Cavernous sinus venography by transbasilic catheter technique.


Diagnostic value of stationary potential measurement in head injuries.


Significance of vascular notching of optic nerves and chiasm on visual disturbance.


Malignant primary meningeal tumors.

Malignant primary meningeal tumors.


Stiffness of cerebral arteries--its role in the pathogenesis of cerebral aneurysms.


The suppressive effect of antibodies on cellular cooperation. 1) The primary and secondary anti-carrier antibody responses were markedly suppressed by the passively administered anti-carrier antibody but not by the anti-hapten antibody. 2) The primary and secondary anti-hapten antibody responses were suppressed not only by the passively administered anti-hapten antibody but also by the anti-carrier antibody. 3) Passively administered 3.5S fragments of the anti-carrier antibody selectively suppressed the anti-carrier antibody response but had no effect on the capacity of carrier-specific helper T cells to facilitate the anti-hapten antibody response. 4) Passively administered anti-carrier antibodies did not suppress the development of carrier-specific helper T cells but suppressed B memory cells specific for the haptenic group as well as the carrier determinant.


Dural calcification from the neurosurgical point of view.


Cerebrovascular Moyamoya disease. IIIrd report--the study on the aging of the perforating branches and the possibility of collateral pathway.


Anterior communicating artery aneurysm not visualized by angiography. Report of two successfully operated cases.


The place of intra-arterial methylene blue vital stain and histochemistry of acetylcholinesterase in experimental neurology and psychiatry.


Effects of metrizamide on silver staining of aortic endothelium. A comparison with metrizoate media in rats.


Mitochondrial uptake of calcium ions and the regulation of cell function.


Immunoglobulin production in B-lymphocytes: synthesis of the membrane-bound receptor and the secreted serum glycoprotein immunoglobulin M.


A comparative analysis of extrinsic fluorescence in nerve membranes and lipid bilayers.


Clinical use of radiation sensitizing agents.


A new way to demonstrate the capillary beds at light microscopy.


The use of tannin-iron method as a nervous system general stain technique.


Radiotherapy of bronchogenic carcinoma.

Radiotherapy of bronchogenic carcinoma.


The production of markers by bronchogenic carcinoma: a review.


The role of chemotherapy in the treatment of lung cancer.


In vitro testing in tumor immunotherapy.


Serologic characterization of selected bluetongue virus strains from the United States.


The control of outbreaks of leptospriosis in beef cattle by simultaneous vaccination and treatment with dihydrostreptomycin.


Antigenic variation of Venezuelan strains of foot and mouth disease viruses.


The immune system: a web of V-domains.

The immune system: a web of V-domains.


The dental school and the university: a case for unification.


The Pennsylvania approach.

The Pennsylvania approach.


Basic sciences at Pennsylvania. Continuity and commitment.


Characterization of a long-term suspension culture of the LLC-MK monkey kidney cell line.


Basic sciences in the DMD cirriculum.

Basic sciences in the DMD cirriculum.


A PDJ poll. A profile of student interest in research.


To disaggregate or not to disaggregate injury and cell disaggregation, transient or permanent?


Opportunities for research (a guide to obtaining summer research).


COHR-what is it, where is it going?

COHR-what is it, where is it going?


"SEM" becomes part of dentistry's lingo.


Biosynthesis of collagen in the periodontal ligament.


A technique for replacement of anterior teeth in the adolescent patient; a case presentation.


The dentist: a multidimensional man.

The dentist: a multidimensional man.


The externist or how to get the devil out of the dental school.


"The forest through the trees...".

"The forest through the trees...".


The effect of preoperative combined bleomycin and radiation therapy in hilar bronchial carcinoma.


New techniques in the diagnosis of acute pulmonary embolism.


The comprehensibility of dental health literature.


The diagnostic value of amniocentesis.

The diagnostic value of amniocentesis.


Structural features of streptolysin O.

Structural features of streptolysin O.


Trichomonas vaginalis, a pathogen of prostatitis.


Deaths from appendicitis and appendicectomy.


Recombinant influenza-A viruses as live vaccines for man. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines. The infection of volunteers with five hybrid influenza-A viruses is described. Four of these were produced in Great Britain by recombining an Ao virus, non-infective for man, with a wild Hong Kong like strain. The fifth was the American recombinant, X-31, derived from similar parents and widely used in the manufacture of killed vaccines. All five viruses had the haemagglutinin and neuraminidase of A2/Hong Kong/68. Two of the viruses were not attenuated and induced symptoms of clinical influenza. The other three were appreciably attenuated and were infective and antigenic. It seems that recombination is a rapid and effective way of producing live vaccine viruses to specification. It is also the quickest known method of attenuation.


Controlled trial of azathioprine in Crohn's disease. The effect of azathioprine in patients with active Crohn's disease has been evaluated in a double-blind cross-over trial. Fifteen patients were treated with both azathioprine and placebo: only two improved while on azathioprine, six got worse, and in seven there was no change. The drug seemed to be the cause of deterioration in two of the patients. Although the drug may be of some value in a few patients, it should be used with caution and only when other measures have failed.


Disinfection of the umbilicus for abdominal surgery. Bacteriological investigation of the adult umbilicus showed that it is much more profusely colonised by bacteria than the rest of the abdominal skin. Routine preoperative treatment with alcoholic chlorhexidine solution did not disinfect the umbilicus satisfactorily. Better results were achieved by disinfection with povidone iodine followed by alcoholic chlorhexidine.


Separation of rubella IgM, IgA, and IgG antibodies by gel filtration on agarose. Identification of the immunoglobulin classes of rubella antibodies is the only reliable tool for the diagnosis of a recent primary infection with rubella within 6-8 weeks of infection. Gel filtration permits the separation of IgM and IgA antibodies, both characteristic for a recent infection, from persistent rubella IgG antibody (which indicates pre-existing immunity). Gel filtration on agarose offers advantages over the other methods for separating immunoglobulin classes. Fractionation of specific rubella antibodies is important not only in all cases where a serum sample was taken too late and a rise of antibody titre missed, but also in cases with significant antibody rise to distinguish a secondary immune response after rubella reinfection.


Atherosclerosis and vitamin C.

Atherosclerosis and vitamin C. Following the chance observation that the author's serum-cholesterol could be varied between 140 and 230 mg. per 100 ml. by increasing the vitamin-C intake or by lowering it, a study was undertaken in healthy individuals and in patients with atherosclerosis. In healthy people under the age of 25, cholesterol levels tended to fall when 1 g. of vitamin C per day was added to an otherwise normal diet. In older people, no consistent pattern of serum-cholesterol change was seen, but in patients with a history of atherosclerosis, most of whom were on clofibrate and/or anticoagulants, the serum-cholesterol increased in the weeks when vitamin-C supplements increased in the weeks when vitamin-C supplements were given. It is suggested that this rise in serum-cholesterol is caused by mobilisation of the arterial cholesterol.


Effects of sodium intake on inherited hypertension in the rat. The effect of sodium chloride intake on systolic blood-pressure was studied in genetic hypertensive Wistar rats. In these animals hypertension can develop on a sodium-"free" diet, but the height to which the blood-pressure rises is related to the sodium intake; increasing the amount of potassium in the diet promotes sodium excretion and ameliorates the hypertension. It is suggested that this form of inherited hypertension may be determined by two different sets of autosomal alleles only one of which is sodium-dependent.


Skin cancer and immunosuppression.

Skin cancer and immunosuppression. 7 (14%) out of 51 kidney-allograft recipients developed a total of 19 malignant skin tumours four to forty-five months after transplantation. Immunosuppressive treatment, known to be associated with an increased risk of development of tumours of lymphoreticular type, also enhances the occurrence of squamous-cell carcinoma. Under the influence of immunosuppression cutaneous hyperkeratoses more rapidly evolve into squamous-cell carcinoma, multiple skin cancers occur in some patients, and keratoacanthoma is not only more frequent but also prone to early recurrence.


Contribution of fetal/maternal incompatibility to aetiology of pre-eclamptic toxaemia. Data are presented on an association between toxaemia of pregnancy and consanguinity of patients, seen at a Turkish hospital, and their husbands. Women with toxaemia were less frequently related to their husbands than those with no signs of pre-eclampsia. The relationship between toxaemia in twin pregnancies and the sexes of the twin pairs from four sources are examined. In all four pre-eclampsia seems to be more common in unlike-sex than in like-sex twin pregnancies, and, by extension, to be more common in dizygous than in monozygous twin pregnancies.


A "new" disorder of isoleucine catabolism. A disorder of isoleucine catabolism was found in a child with intermittent metabolic acidosis. The block occurs at the stage of propionate synthesis, and two intermediates--alpha-methylacetoacetate and alpha-methyl-beta-hydroxybutyrate--accumulate. The condition is apparently inherited.


Insensitivity of respiratory centre to carbon dioxide in the Enga people of New Guinea. The ventilatory response to a rising carbon-dioxide (CO2) tension has been determined in healthy New Guinea natives using a new apparatus which was developed for field-work. The response in New Guineans did not vary greatly between individuals, in contrast to the finding in healthy Caucasians. In all twelve New Guinean subjects the indices of response fell in the lowest range of Caucasian response. These findings suggest that genetic and racial factors account for the marked variability of the ventilatory response to CO2 in normal man. It is suggested that inherited insensitivity of the respiratory centre in New Guineans (and in some Caucasians) leads to unusually severe disturbances of blood gases in chronic lung disease. This hypothesis is supported by published data relating arterial PCO2 and the severity of airways obstruction in New Guineans.


Newborn-infant heater.

Newborn-infant heater.


A palatal incision.

A palatal incision.


The coronary arteriogram.

The coronary arteriogram.


Aetiology of vitiligo.

Aetiology of vitiligo.


Evolution by gene and chromosome duplication.


Occupational health: a new/old bill.

Occupational health: a new/old bill.


Breakthrough.

Breakthrough.


Reorganising the delivery and payment of health care in the United States.


Health care in America--privilege or right?


What priorities for health?

What priorities for health?


Case-fatality of hyperplasia of the prostate in two teaching and three regional-board hospitals. Mortality of hyperplasia of the prostate, as in many common conditions, is higher in the regional board than the teaching hospitals of England and Wales. 932 men with simple hyperplasia of the prostate consecutively admitted to two teaching and three regional-board hospitals have been studied. There were 5 deaths among 556 men admitted from the waiting-list, and negligible variation between hospitals. Among the 376 unplanned emergency admissions were 35 deaths, 26 of them in 71 men who did not have prostatectomy. Unplanned admissions, especially those not operated on, were older than the rest and mostly in acute retention, and many also had cardiovascular and other disease. 78% of the admissions to two of the regional-board hospitals were unplanned; the operation-rate on these men was generally low and case-fatality among them was 14%. In contrast, only 22% of the admissions to the two teaching hospitals were unplanned, nearly every case was operated on, and the case-fatality was 4.3%. These two regional-board hospitals with relatively small resources were carrying more than their share of the most difficult cases. A national survey to assess the treatment of hyperplasia of the prostate is now indicated, but it is time the National Health Service gathered this kind of information routinely.


Cerebral atrophy in young cannabis smokers.


Possible role of saliva in the sudden infant-death syndrome.


Aspirin-induced hypoglycaemia in a patient on haemodialysis.


Precapillary bypass and sudden infant death.


The social fate of the amputee.

The social fate of the amputee.


Is selenium a teratogen?

Is selenium a teratogen?


Iron losses and iron requirements.

Iron losses and iron requirements.


Stomach cancer after gastric operations for benign conditions.


Effect of alcohol on glucose tolerance.

Effect of alcohol on glucose tolerance.


Water intoxication in beer-drinkers.

Water intoxication in beer-drinkers.


Neutropenia in people of African origin.


Tests for toxoplasmosis.

Tests for toxoplasmosis.


Fetal karyotype from amniotic cells without culturing.


Childhood cancer following obstetric radiography.


Drug resistance in Trichomonas vaginalis.


Aetiology of retrograde amnesia.

Aetiology of retrograde amnesia.


Identification of thymic-dependent lymphocytes.


Fusidic acid in psoriasis.

Fusidic acid in psoriasis.


Glycerol in acute cerebral infarction.

Glycerol in acute cerebral infarction.


Interaction between warfarin and phenformin.


Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition.


Plasma-zinc concentration in patients with bronchogenic cancer.


Bromism.

Bromism.


Infiltration of adrenaline before thyroidectomy.


Low-dose combination chemotherapy of disseminated human neoplasms.


Antenatal detection of Hurler's syndrome.


Lithium and mitotic index.

Lithium and mitotic index.


When to remove the I.U.D.

When to remove the I.U.D.


Hospital siting and patient visiting.

Hospital siting and patient visiting.


B lymphocytes in macroglobulinaemia.

B lymphocytes in macroglobulinaemia.


Electrical safety in hospitals.

Electrical safety in hospitals.


Sex ratio in hyperphenylalaninaemia.

Sex ratio in hyperphenylalaninaemia.


Tests for porphyria.

Tests for porphyria.


Screening test for Y chromosome in newborn using urinary epithelial cells.


Effects of contraceptive hormone preparations on the fine structure of the endometrium.


Oral contraceptives and hypertension.

Oral contraceptives and hypertension.


Early and intensive therapy of intravascular coagulation in acute liver failure. Four consecutive patients, three with fulminant hepatic failure and one with a severe relapse of serum hepatitis, who showed evidence of intravascular coagulation, were treated intensively with heparin and fresh frozen plasma. Rapid correction of the coagulation disturbance was achieved, and all four patients recovered completely. The necessity for starting such treatment early in the course of the disease and before the onset of major gastrointestinal bleeding is stressed, and it is suggested that intravascular coagulation may act as an intermediary in the pathogenesis of the hepatic necrosis.


Sexual function following aortoiliac reconstruction. Impotence due to atherosclerotic disease of the aorta and iliac arteries presents as failure to achieve erection. Sterility after aortoiliac reconstructive surgery is more common and presents as inability to ejaculate. If the superior hypogastric sympathetic plexus (presacral nerve) is preserved, sexual function can be maintained in 90% of cases.


New antigen-antibody system in Australia-antigen-positive hepatitis. After detergent treatment the 42 nm. Dane particles from the sera of patients with serum hepatitis separate into an outer coat of Australia antigen (Au-Ag) and an inner spherical 27 nm. diameter component resembling a rhinovirus. Antibody in post-hepatitic serum reacted with the inner component (but not with the outer) to yield aggregates resembling those seen in the liver of patients with serum hepatitis. Antibody to Au-Ag was not detected, before or after the attack of hepatitis. It is suggested that, in an attack of serum hepatitis, Au-Ag antibody develops but is subsequently cleared; antibody against the inner Dane component, however, persists.


Cerebral atrophy in young cannabis smokers. Evidence of cerebral atrophy was demonstrated by air encephalography in ten patients with histories of consistent cannabis smoking over a period of 3-11 years. The average age of the patients was 22 years; all were males. Amphetamines and lysergide (L.S.D.) had also been taken, but in much smaller amounts. Measurements of the lateral and third ventricles were significantly different from those in thirteen controls of a similar age-group.


Abnormal insulin response in patients with small-vessel disease. The insulin response to a glucose load has been investigated in twenty-five patients with small-vessel disease (ischaemic lesions of toes or feet in the presence of foot pulses). The clinical presentation was similar to that of juvenile diabetic microangiopathy, but in small-vessel disease there was no glucose intolerance. Unexpectedly in the patients with small-vessel disease there was no striking insulin secretion response to the stimulus of a glucose load. Controls increased their circulating insulin levels on average sixfold over fasting levels after 50 g. oral glucose: all the small-vessel-disease patients had increases of less than three times their fasting levels, and nine of them had completely flat curves throughout the test. Tolbutamide also did not stimulate insulin secretion. The refractory state of these patients' responses to the normal stimulus of insulin output has similarities to the picture in juvenile diabetes mellitus and may be important in the aetiology of the small-vessel lesions.


Insulin response to glucose in patients with peripheral vascular disease, arteritis, and Raynaud's phenomenon. Twenty-three patients with peripheral vascular disease due to atheromatous blocks in large vessels, four patients with arteritis, and twenty patients with Raynaud's phenomenon were tested for insulin response to glucose. (In an earlier investigation patients with small-vessel peripheral vascular disease did not secrete insulin in response to a glucose load--a previously unreported finding.) Insulin output after glucose in patients with atheromatous blocks in large peripheral arteries fell into three categories: (1) normal glucose tolerance and insulin output, the insulin rise (peak/basal ratio) comparing well with the rise in controls; (2) carbohydrate intolerance with a prediabetic pattern of glucose-tolerance test, and raised circulating insulin levels both fasting insulin and after glucose, so that the insulin rise was lower than normal; or (3) the flat insulin responses after glucose that had been noted in small-vessel disease with normal glucose tolerance. Thus in these twenty-three patients with large-vessel blocks presenting with peripheral vascular disease the high and late insulin secretion after glucose reported by other workers for patients with atheroma could not be confirmed. High but not delayed insulin peaks were seen after a glucose stimulus in some patients with arteritis and with Raynaud's phenomenon.


External method for detection of fetal breathing in utero. An ultrasonic technique for detecting fetal breathing in utero has been developed using chronic fetal lamb preparations, and has been used successfully in pregnant women.


Antecubital venepuncture in neonates.

Antecubital venepuncture in neonates.


Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). 63 patients on long-term oral therapy with phenytoin sodium (sodium diphenylhydantoin) were screened for abnormalities of immunological function. They were compared with 92 controls and 28 patients with lymphoma. Depression of cellular or humoral immunity, or both, was found in a significant number of phenytoin-treated and lymphoma subjects. Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D.H.S.) to three common skin-test antigens (22%), and depression of in-vitro lymphocyte transformation by phytohaemagglutinin (27%). Lymphoma patients manifested low IgM (22%), and inability to make antibody to S. typhi (11%) and to tetanus toxoid (21%). D.H.S. was absent in 36%; lymphocyte transformation was depressed in 17%. Abnormal lymphocyte transformation did not correlate with depression of cellular or humoral immunity in either group.


Instrument for sampling ovarian surface cells at laparoscopy.


Autoclave which sterilizes with highly purified steam for tissue-culture laboratories.


How safe is abortion?

How safe is abortion?


Cannabis encephalopathy?

Cannabis encephalopathy?


Research and the government.

Research and the government.


Cromoglycate in asthma and hayfever.

Cromoglycate in asthma and hayfever.


Australia antigen.

Australia antigen.


More on S.M.O.N.

More on S.M.O.N.


Sensory deprivation.

Sensory deprivation.


Legal abortion: a critical assessment of its risks. A review of the methods used and the results obtained in 1182 legal abortions in one teaching hospital confirms that termination of pregnancy, even in the early weeks, is neither simple nor safe. Nearly 17% of patients lost more than 500 ml. of blood and 9.5% required transfusion. Cervical lacerations occurred in 4.2% and the uterus was perforated in 1.2%. All the perforations were associated with the technique of vacuum aspiration. Emergency laparotomy was required for 6 patients and hysterectomy was twice necessary to save life. Pyrexia of 38 degrees C or more persisting for longer than 24 hours occurred in 27%. Peritonitis developed in 14 patients, with paralytic ileus in 7, and 6 others had septicaemia. No patient died. The need is stressed for a wider appreciation of the risks involved in allowing certain pregnancies to continue and those associated with their termination, irrespective of the method used. Methods of reducing certain of these risks are indicated.


Effects of the abortion law, 1967, on a gynaecological unit. In the United Kingdom the more liberal attitude towards abortions engendered by the 1967 Act has increased the work of a gynaecological unit at Salford, Lancashire, by about 10%. In 1964-65 there were 15 therapeutic abortions, and in 1969-70 the number had increased to 447. The increased demand has been catered for by a reduction of stay in gynaecological patients: in fact, the "through-put" has increased and the waiting-list diminished. The increased work-load on the blood transfusion service has been slight, and on the credit side there has been a reduction in the numbers of septic abortions. The major problem has been in the outpatient department, since these cases are time-consuming and it is difficult to make a fair and impartial decision.


Treatment and prevention of sickle-cell crisis.


Mechanism for the high incidence of sickle-cell crisis in the tropical cool season.


Regression of neuroblastoma.

Regression of neuroblastoma.


Treatment after exposure to cold.

Treatment after exposure to cold.


Urinary-tract infection and low-dose nitrofurantoin.


Urinary infection by coagulase-negative staphylococci.


Oesophageal candidiasis and carcinoma of the oesophagus.


Intravascular changes in the retina during open-heart surgery.


Smoking and neuroticism.

Smoking and neuroticism.


Analgesic abuse.

Analgesic abuse.


Lung cancer among populations having lung irradiation.


Goodpasture's syndrome.

Goodpasture's syndrome.


Nitroblue tetrazolium test in asthma and dysgammaglobulinaemia.


Aid for the adolescent.

Aid for the adolescent.


Myelo-optic neuropathy induced by clioquinol in animals.


Practolol treatment in asthmatics.

Practolol treatment in asthmatics.


Inhibition of transformation of normal lymphocytes by plasma factor from patients with Hodgkin's disease and cancer.


Probenecid test in Parkinson's disease.

Probenecid test in Parkinson's disease.


Corpus alienum nasi nocte inhalation.

Corpus alienum nasi nocte inhalation.


Hepatitis-associated antigen in human bile.


An epiphysometer and the community diagnosis of nutritional rickets.


Use of split-screen video tapes for ultrasound training.


Bibliography of developmental medicine and child neurology. Selected books and articles received in 1973.


Osmium tetroxide-zinc iodide reactive sites in the photoreceptor cells.


Smoking, coughing, laughing and applause: a comparative study of respiratory symbolism.


A dynamic presentation of physiological phenomena.


The value of immunofluorescence in the diagnosis of glomerulonephritis not related to systemic diseases.


Fine structural cytochemistry of granules in atrial cardiocytes.


Treatment of stage-II carcinoma of the female breast.


Anomalous volume change of gramicidin A in ethanol solutions.


Glutamate dehydrogenase from human liver. III. Antibody-binding sites and properties of the antigen-antibody complex.


The molecular basis for the storage and release of histamine in rat mast cell granules.


Biomedical communications: the state of the art.


Steroid protein interactions. XXVIII. The isoelectric point and pH stability of the progesterone-binding globulin.


Agents which inhibit reverse transcriptases.


A rapid method for studying vascular patterns three dimensionally and histologically.


Urinary excretion of free norepinephrine and free epinephrine in patients with acute myocardial infarction in relation to its clinical course.


Genetic polymorphism of gamma-globulins in man.


Immunoglobulin abnormalities in families of patients with Waldenström's macroglobulinemia.


The palliative treatment of recurrent carcinoma of rectum and rectosigmoid with 2 mv. radiation. Some results and description of a technique.


Palliative irradiation for bladder carcinoma.


Introduction to the histochemical study of carbohydrate metabolism in the lymph vascular wall.


Epiphyseal growth: speculations on the nature of Perthes's disease.


Analyses of obstructed micturition.

Analyses of obstructed micturition.


Motor vehicle exhaust at three selected sites.


Carbon monoxide control in a high highway tunnel.


Irradiated automobile exhaust. Its effects on the reproduction of mice.


Acute toxicity of irradiated auto exhaust. Its indication by enhancement of mortality from streptococcal pneumonia.


Lindane and hematologic reactions.

Lindane and hematologic reactions.


Experience with the Souttar tube in esophageal carcinoma.


Developmental evaluation and therapy program. Functional approach to developmental delays in infant behavior.


Smoking--a world problem.

Smoking--a world problem.


The effect of 5-fluorouracil on adrenocortical and pituitary function.


Light-microscopic and immunopathologic observations on cadmium chloride-induced injury in mature rat testis.


A light- and electron-microscopic study of bacterial invasion in Whipple's disease.


A palliative procedure for high bile duct carcinoma.


Degos' acanthoma (acanthome a cellules claires). A clinical and histological report of nine cases.


Spontaneous electrical activity of human muscle.


A new experimental method for evaluating drugs in the nasal cavity.


Pathways of descending influence on H reflex during sleep.


Electroencephalographic studies in "split brain" cats.


Effect of brain lesions on conditioned cortical electropotentials.


The evoked cortical somatosensory response in normal man and its modification by oral lithium carbonate.


Depth electrographic studies on the caudate nucleus in man.


Hypnotic suggestions and visually evoked potentials.


Unilateral suppression of vertex sharp waves in the sleep electroencephalogram (case report).


Fabrication of suction-cup electrodes for electromyography.


A method for analyzing variations in evoked responses.


An implanted electrode for recording both rapid eye movements and muscle tone during sleep.


Summated human EEG potentials with voluntary movement.


Diffuse regulation of visual thalamo-cortical responsiveness during sleep and wakefulness.


Interaction of evoked potentials in the anterior thalamus of the cat.


Electrocorticogram during whole body vibration.


Acoustic habituation in cats as a function of stimulus rate and the role of temporal conditioning of the middle ear muscles.


An EEG-behavioral study of sodium hydroxybutyrate in humans.


Observations on the passive electrical properties of the envelopes of cat brain.


Electrical transmission properties of the cranium of the dog to steady currents.


Changes in total amount of stage four sleep as a function of partial sleep deprivation.


Restoring rectangular pulses of stimulation current.


Studies on biologic properties of tuberculin-active peptide. Antigenicity of tuberculin-active peptide in indirect hemagglutination and hemolytic reaction.


Effects of thiouracil on rat liver alpha-glycerophosphate dehydrogenase and serum PBI responses to L-thyroxine.


Effects of phenethyl alcohol on chromosomes of Allium cepa.


A concept of otolaryngologic allergy.

A concept of otolaryngologic allergy.


The role of cytoplasmic membranes in the regulation of water concentration within frog oocytes.


Configuration of endocardial and intramural extrasystoles in the dog.


Relation of vulnerability to ECG and action potential characteristics of premature beats.


Microspectrophotometry of trypsin-Leishman-stained human chromosomes.


Hypertension, diabetes mellitus, and blood groups in benign prostatic hypertrophy.


Genesis and evolution of ectopic ventricular rhythm.


Injection treatment of enlarged prostate.


The arthritis of familial Mediterranean fever (FMF).


An immunofluorescent study of the skin lesions in systemic lupus erythematosus.


Study of cutaneous innervation in congenital anesthesia.


Fetal maturation and amniotic fluid.

Fetal maturation and amniotic fluid.


Pterygium and pinguecula: electron microscopic study.


The influence of splitting off sialic acid on activity of human erythrocytes toward H and HI antibodies.


Differences of H specificity of human group O erythrocytes.


A and B blood group specificities of stroma fractions of cord blood erythrocytes.


Occurrence of gamma-globulin-like antigens in bacteria.


Occurrence of anti-gamma-globulin antibodies in human sera.


Paroxysmal ventricular tachycardia with rate-dependent coupling intervals.


Release of thyroxine from the liver during anaesthesia and surgery.


Anaesthesia for cardioversion: thiopentone with and without atropine premedication.


Banding of the pulmonary artery for transposition of the great arteries and ventricular septal defect.


Evaluation of an antidiuretic effect in cancer.


Acute respiratory distress in adults.

Acute respiratory distress in adults.


The cri-du-chat syndrome with an apparently normal karyotype.


Specific inhibition of the Prausnitz-Küstner reaction by an atypical human myeloma protein.


Intravascular Salmonella typhi as a manifestation of the carrier state.


Effects of anti-inflammatory drugs on lymphocytes.


Withdrawal fits in barbiturate addicts.

Withdrawal fits in barbiturate addicts.


Ketone bodies and the inhibition of free-fatty-acid release.


Intraduodenal glucose infusion and pancreatic secretion in man.


Modern concepts of free-fatty-acid and blood-glucose homoeostasis in diseases involving altered lipid metabolism.


A new oxygen tent.

A new oxygen tent.


A self-inflating cuffed neonate tracheostomy tube suitable for intermittent positive-pressure respiration.


The persistent Salmonella.

The persistent Salmonella.


"Allergic gastroenteropathy".

"Allergic gastroenteropathy".


Brucellosis in the dairy-farming community and allied workers of Worcestershire.


Supervision of clinical investigations. Report by Royal College of Physicians.


Three doctors and the American Revolution.


Chloramphenicol and jaundice in a baby.

Chloramphenicol and jaundice in a baby.


Neurotoxic side-effects of piperazine.

Neurotoxic side-effects of piperazine.


Amitriptyline and sputum viscosity.

Amitriptyline and sputum viscosity.


The management of malignant tumors of the nasal sinuses.


The medical treatment of sinusitis.

The medical treatment of sinusitis.


The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.


Histochemical duality of rabbit intrafusal fibers.


Influence of various catatoxic steroids upon chronic dihydrotachysterol intoxication.


Mechanism of immunologic unresponsiveness: a new approach.


Alopecia from oral contraceptives.

Alopecia from oral contraceptives.


Photoperiods and age as factors modifying the effects of kepone in Japanese quail.


Antiplasmins.

Antiplasmins.


Antinuclear factors in rheumatoid arthritis. Increasing organ-non-specificity with increasing reactivity of rheumatoid factor with heterologous gamma globulin.


A study of serum proteinogram and its correlation with severity and duration in tubercular meningitis.


Specific stroma in the cortex and medulla of the ovary. Cell types and vascular supply in relation to follicular apparatus and ovulation.


Achilles reflex speed during pregnancy.

Achilles reflex speed during pregnancy.


Synergistic effect of combinations of sulfamethoxazole, trimethoprim, and colistin against Pseudomonas maltophilia and Pseudomonas cepacia. Eighteen strains of Pseudomonas maltophilia and eight strains of P. cepacia were tested for susceptibility to sulfamethoxazole, trimethoprim, and colistin in different combinations. A synergistic effect was found against most of the strains.


Refsum's disease. A clinical and pathological report.


The young child's development of sentence comprehension: influence of event probability, nonverbal context, syntactic form, and strategies.


Variations in children's concepts by age and category.


The effects of adult models and described alternatives on children's choice of behavior management techniques.


Prior help, ego development, and helping behavior.


Children's recognition of reversals of geometric figures.


Letter reversals in naming, writing, and matching to sample.


The ability of six-year-olds, eight-year-olds, and adults to abstract visual patterns.


Cognitive integration in children's memory for sentences and pictures.


The effect of verbal cues on concept acquisition and retention in normal and educable mentally retarded children.


Recognition memory in Down's syndrome and normal infants.


Pleasure derived by children from cognitive challenge and mastery.


Development of peer interactions of monkeys reared in a nuclear-family environment.


Anxious attachment and defensive reactions associated with day care.


The use of perceptual cues for number judgment by young children.


How preschool children understand missing complement subjects.


Cognitive maps in children and men.

Cognitive maps in children and men.


The role of number and length cues in children's quantitative judgments.


Attention and manipulative play in the one-year-old child.


Relationships among Piagetian, IQ, and achievement assessments.


Reflectivity, internality, and animistic thinking.


Observational learning of motives and consequences for television aggression: a developmental study.


A structural-developmental analysis of levels of role taking in middle childhood.


Value and chroma discriminations of young children and adults.


Birth order, verbal intelligence, and educational aspiration.


Acquisition and transfer of sorting mechanisms in discrimination learning and free recall by nursery school children.


Comparison of the retention of preschool and second-grade performers and observers under three verbalization conditions.


The development of time concepts through conflict based on a primitive duration capacity.


Social and familial correlates of self-esteem among American Indian children.


Socioeconomic status differences in children's discrimination learning as related to the reward and information functions of response-contingent stimuli.


Conservation of different quantities among preschool children.


Negative teacher expectation and IQ change in children with superior intellectual potential.


An analysis of analogical reasoning in children.


The effect of need for approval and incentives upon children's probability learning responses.


Social stimulation of vocalizations in delayed infants: familiar and novel agent.


Generalized habituation of concept stimuli in toddlers.


Birth order, family configuration, and verbal achievement. Two samples of National Merit Scholarship participants test in 1962 and the entire population of almost 800,000 participants tested in 1965 were examined.  Consistent effects in all 3 groups were observed with respect to both birth order and family size (1st born and those of smaller families scored higher).  Control of both socioeconomic variables and maternal age, by analysis of variance as well as by analysis of covariance, failed to alter the relationships.  Stepdown analyses suggested that the effects were due to a verbal component and that no differences were attributable to nonverbal factors.  Mean test scores were computed for detailed sibship configurations based on birth order, family size, sibling spacing, and sibling sex.


Judgment and imaging aspects of operations: a Piagetian study with Korean and Costa Rican children.


Modification of young children's grouping strategies: the effects of modeling, verbalization, incentives, and age.


Development of pictorial depth perception: cross-cultural replications.


The comparative ease of processing standard English and black nonstandard English by lower-class black children.


The development of the category-recall function under three retrieval conditions.


Personal organization in children's free recall.


Recognition, formulation, and integration in the development of interrogative strategies among normal and retarded children.


Primacy effects in short-term memory with the mentally retarded.


Instrumental ideation in delay of gratification.


Imposed inhibition and delay of gratification.


Does imagery retard conceptual behavior?


Joking and appreciation of humor in nursery school children.


The effects of being imitated on children's responses in a marble-dropping task.


Altering the questioning strategies of preschool children.


The perception of eye contact in children and adults.


Early peer-group interaction and role-taking skills: an investigation of Israeli children.


Class-inclusion failure: cognitive deficit or misleading reference?


Observed maternal behavior with four-year-old boys and girls in lower-class families.


Television as baby-sitter: a field comparison of preschoolers' behavior during playtime and during television viewing.


Self-concept as related to achievement and age in learning-disabled children.


Effects of extrinsic rewards on children's subsequent intrinsic interest.


Discrimination learning in normal and retarded children as a function of instructions, cue locus, and cue relevance.


Discrimination of schematic faces by nursery school children.


Developmental differences in infants' attentional responses to face-voice incongruity of mother and stranger.


Effects of age, sex, and partner on children's dyadic speech.


The effects of preference for visual complexity on habituation of visual fixation in infants.


A developmental study of strategies of visual selectivity.


Effect of spatial separation of stimuli on children's discrimination learning.


The influence of dimensional manipulations on class-inclusion performance.


Cohort, age, and imagery in children's paired-associate learning.


The postnatal growth of visual capacity.


On the psychological reality of cognitive structures: a tentative synthesis of Piaget's and Bruner's theories.


A basis for identifying stimuli which control behaviors in natural settings.


The effects of sociodramatic play on problem-solving behavior among culturally disadvantaged preschool children.


Information-generated influence as a function of locus-of-control patterns in children.


A system for monitoring crying and noncrying, large, medium, and small neonatal movements.


Obstetrical pain-relieving drugs as predictors of infant behavior variability.


Characteristics of crying and noncrying activity of full-term neonates.


Visual preferences of four-month-old premature and full-term infants.


A neurological and behavioral comparison of African and European newborns in Uganda.


Planfulness and recognition memory.

Planfulness and recognition memory.


The development of a preference for logical consistency in school mathematics.


Investigations of the meaning of "different" in the language of young children.


Transmission of hepatitis.

Transmission of hepatitis.


The use of symbolic modeling to promote social skills in preschool children with low levels of social responsiveness.


Fluoridation in Canberra. II. Dental caries after six years.


Closing volume in healthy non-smokers.

Closing volume in healthy non-smokers.


Oral orciprenaline, salbutamol and isoetharine compared.


Lipogenic enzyme activity in adipose tissue during the growth of swine with different propensities to fatten.


A comparison of husband-wife responses to pregnancy.


Partial purification and some properties of the uridine diphospho-N-acetylglucosamine-enolpyruvate reductase from Staphylococcus epidermidis. A method for the partial purification of the uridine diphospho-N-acetylglucosamine-enolpyruvate reductase from Staphylococcus epidermidis is presented. Some properties of the enzyme, including its dependence on monovalent cation and flavine adenine dinucleotide, are discussed.


Effect of vitamin D3 on the transformation of 7-dehydrocholesterol to cholesterol in the rat liver.


Physician's assistants--nurse associates. An overview.


Role of catecholamines in the control of melanocyte-stimulating hormone secretion in rats.


Cellular response to drugs affecting aqueous dynamics.


Industrial injuries of the back and extremities. Comprehensive evaluation--an aid in prognosis and management: a study of one hundred and eighty patients.


Head injury.

Head injury.


Biosynthesis of progesterone from endogenous steroid precursor by the guinea-pig placenta.


Enzyme assays in liver disease.

Enzyme assays in liver disease.


The American Academy of Forensic Sciences: organizing a new intellectual discipline.


Human blood platelets as cellular models for investigation of membrane active drugs: beta-adrenergic blocking agents.


Tektite II; medical supervision of the scientists in the sea. X. The aborted 100-FSW (Minitat) program.


Tektite II: medical supervision of the scientists in the sea. 9. Tektite logistics.


(Glutamine synthetase) tyrosyl-O-adenylate: a new energy-rich phosphate bond.


Enzyme adaptation as a biochemical probe of development and aging.


Mosquito host preference studies in Hale County, Texas.


The footballer's ankle and foot.

The footballer's ankle and foot.


Pneumococcal transformation--a backward view. Fourth Griffith Memorial Lecture.


Training and utilization of feldshers in the USSR.


Enzyme induction in human fetal liver.

Enzyme induction in human fetal liver.


Enzymatic activity hydrolyzing  -glutamyl- -naphthylamide in human intestine during adult and fetal life.


A standardized system for diagnosing, recording and analyzing dental caries data.


-Glutamyl transpeptidase: elevated activities in certain neurologic diseases.


The volunteer rescue squad: the impact of a group on the psychological adaptation of its members.


The effect of regressive ECT with process schizophrenics.


Phenothiazine deaths: a critical review.


Impairment of optokinetic nystagmus in patients with tardive dyskinesia.


Identification and analysis of arachidonic acid in Plexaura homomalla, var. R and var. S.


Alkane oxidation in Candida tropicalis.

Alkane oxidation in Candida tropicalis.


Red cell metabolism. A. Defects not causing hemolytic disease. B. Environmental modification.


A new cardioselective  -adrenoceptor blocking agent.


Contributions of neurochemistry to neurology and psychiatry. Introduction.


Beta adrenergic mechanisms influencing brain steady potential in cats and Rhesus monkeys.


2-Amine 4-pentenoic acid (allylglycine): a proposed tool for the study of GABA mediated systems.


Parkinson's disease: from brain homogenate to treatment.


Activity of glutamate and malate dehydrogenases and the 'malic enzyme' during the development of the chick spinal cord.


Personality processes reflected in client vocal style and Rorschach performance.


Degradation of protocatechuate in Pseudomonas testosteroni by a pathway involving oxidation of the product of meta-fission. In addition to catalyzing the hydrolysis of 4-carboxy-2-hydroxymuconic semialdehyde, formed by meta-fission of protocatechuate, Pseudomonas testosteroni also possesses a nicotinamide adenine dinucleotide(phosphate)-linked dehydrogenase for this compound and can degrade protocatechuate to pyruvate and oxaloacetate.


Interpretation of uninterpretable Minnesota Multiphasic Personality Inventory profiles.


Pyrimidine metabolism in man.

Pyrimidine metabolism in man.


The pharmacology of platelet inhibition.


Immunomorphological methods in the diagnosis of lung diseases.


The undescended testis.

The undescended testis.


Allogeneic interactions provide evidence for a novel class of immunological reactivity.


Allograft response in vitro.

Allograft response in vitro.


Heat treatment of soldered joints in dental casting gold alloys. An electron microprobe analysis.


Interaction of embryonic chicken spleen cells and adult allogeneic leucocytes.


Effect of renal alpha-adrenergic stimulation on proximal tubular sodium reabsorption.


The in vitro response to phytohaemagglutinin (PHA) of leucocytes from intact and thymectomized quokkas.


Studies on the mitochondrial energy-linked pyridine nucleotide transhydrogenase.


The renal circulation in haemorrhagic hypotension. In-vivo renal micro-angiography in the dog.


Small-vessel changes in renal disease.

Small-vessel changes in renal disease.


Modified nucleosides with antineoplastic activity as inhibitors of an enzyme containing adenosine within its coenzyme.


Folate deficiency and formiminoglutamic acid excretion during chronic diethylnitrosamine administration to rats.


Studies on the nature of the bronchial -adrenoreceptors.


Characteristics of disparate histocompatibility barriers in congenic strains of mice. II. Antibody-associated suppression.


The control of dental caries and periodontal disease; a fundamental approach.


Interexaminer variability when using Viegas' simplified caries index.


The enzymatic and immunologic detection of myocardial injury. Selected considerations.


The failing myocardium. I. Drug management.


Experiences with beta-adrenergic blockade drugs in hypertension.


Loss of biological activity of bacteriophage 2C and degradation of its DNA in storage.


Ultraviolet absorption and optical rotatory dispersion studies of deoxyribonucleic acid and nucleohistone.


Oxygen consumption by liver and kidney slices of Uromastix hardwickii.


Studies on carbohydrate metabolism in lizards.


The effect of some sodium substitutes on the receptor potential of the crayfish photoreceptor cell.


Effect on caries susceptibility after surgical treatment of drooling in patients with neurological disorders.


Genetic control of histocompatibility antigens.


Source of pyrrole-2-carboxylate in mammalian urine.


An NAD- and NADP-dependent malic enzyme with regulatory properties in rat liver and adrenal cortex mitochondrial fractions.


On the binding of aflatoxin B 1  and its metabolites to hepatic microsomes.


The role of Ca 2+  in control of malic enzyme activity in bovine adrenal cortex mitochondria.


The role of molybdenum in formation of the NADPH-nitrate reductase by Aspergillus nidulans.


Automated fluorometric method for screening for erythrocyte glucose-6-phosphate dehydrogenase deficiency.


Laboratory Relations Conference.

Laboratory Relations Conference.


Comparison of the virion polypeptides of group B arboviruses. The virion polypeptides of eight group B arboviruses were compared by polyacrylamide gel coelectrophoresis. All contained three polypeptides, V-1, V-2, and V-3. The mosquito-borne viruses had electrophoretically similar small membrane polypeptides (V-1); the tick-borne viruses had a V-1 of significantly decreased mobility.


Allergic responses to biting and stinging insects.


The mosquitoes of the Red Sea area, Egypt.


Resolution of terbutaline, a new  -sympathomimetic amine.


Psychological, demographic and orthopaedic factors associated with prediction of outcome of spinal fusion.


Electroencephalographic effects of bicuculline.


Renal transplantation in rabbits. IX. An immunological study of the allograft reaction in rabbits pre-sensitized by donor kidney homogenate.


The tyrant overcome: a review of the history of anaesthesia in Australia.


Double-blind cross-over clinical trial of oxyfedrine in angina pectoris.


Carrier specificity and the allogeneic effect in mice.


The mediator of cellular immunity. VI. Effect of the antimitotic drug vinblastine on the mediator of cellular resistance to infection. The antimitotic drug vinblastine (Vbl) has a profound impact upon the specifically sensitized lymphocytes that transfer cellular resistance to Listeria monocytogenes. A 12-h pulse of the drug given to prospective donors during the first week of an immunizing Listeria infection inhibits the delivery of protective lymphocytes to the thoracic duct and their subsequent movement into an inflammatory exudate induced in the peritoneal cavity. The effect of Vbl is clearly related to its antimitotic activity, not to an effect on lymphocytes regardless of their position in the division cycle. This conclusion was drawn from an autoradiographic analysis of cells in the lymph of Vbl-treated rats and from failure of the drug to abrogate a known function of small lymphocytes, namely, their ability to initiate a graft-vs.-host reaction. The results imply that large lymphocytes, the rapidly proliferating cells in central lymph, are the principal effector cells responsible for transmitting resistance to L. monocytogenes and provide a plausible explanation for their rapid turnover and short circulating life-span.


Lactate dehydrogenases: structure and function.


Nutritional evaluation of humans during an oxygen-helium dive to a simulated depth of 1000 feet.


Mercury vapour intoxication.

Mercury vapour intoxication.


A comparative cytochemical study of the midgut epithelial cells of local vector mosquitoes unfed and fed in relation to blood meal.


The physician and workmen's compensation. A new paramedic to help with compensation cases. The first social, no-fault, insurance legislation in California was the Workmen's Compensation Act of 1911. It has been changed and modified in the years since, and is having an increasing impact on the practice of most California physicians. Many physicians consider caring for the occupationally ill or injured time-consuming and difficult. A newly emerging kind of paramedic, the workmen's compensation benefit administrator, is available to assist the physician in overcoming difficulties encountered. A cooperative effort between the physician and the benefit administrator will expedite management of industrial patients.


The rise and fall of pneumonia-control programs.


The choice of alternative antidepressants.


Replantation of avulsed anterior teeth in patients with jaw fractures.


Cryptorchidism reassessed. Is there an optimal time for surgical correction?


Preparation of hyperthyroidism using a beta-adrenergic blocker "Trasicor".


The neurohumoral control of pancreatic exocrine secretion.


The Rhesus monkey as a model for the study of infectious disease.


Drugs in management of minimal brain dysfunction.


Minimal brain dysfunction. V. Diagnosis and treatment. B. Drug treatment. Drug therapy: initiation and follow-up.


Reduced triphosphopyridine-liked aldehyde reductase. II. Species and tissue distribution.


Turnover of dihydrofolate reductase in rapidly dividing cells.


Activation of rabbit kidney fructose diphosphatase by Mg-EDTA, Mn-EDTA and Co-EDTA complexes.


The effect of NADP on the subunit structure and activity of spinach chloroplast glyceraldehyde-3-phosphate dehydrogenase.


Two isoenzymes each of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in spinach leaves.


Studies of cytochrome P-450 in testis microsomes.


Sickle cell crisis associated with drugs.


ACTH stimulation of purine nucleotide biosynthesis in the adrenal cortex. ACTH stimulation of purine biosynthesis.


Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.


Isocitrate dehydrogenase from Azotobacter vinelandii. Order of substrate addition and product release.


The cardiovascular actions of WR-149,024 (1,18-diamino-7,13-diaza-9,10-dithiaoctadecane tetrahydrochloride). 1. The general cardiovascular properties of WR-149,024 (a straight chain sulphur-containing aliphatic amine) in dogs and cats are reported.2. Intravenous administration of this compound produced an immediate hypotension and bradycardia in intact anaesthetized dogs. These effects were independent of the parasympathetic nervous system since they were also present in atropinized and bilaterally vagotomized dogs.3. Ascending aortic blood flow increased after administration of WR-149,024 despite a reduction in blood pressure, contractile force and heart rate. It appears that the initial hypotension is due to a decrease in total peripheral vascular resistance since WR-149,024 produced relatively little change in force of contraction or heart rate in the isolated, blood-perfused heart preparation.4. WR-149,024 reversed the pressor effects of adrenaline within 10 min of injection while at the same time the vasopressor response to angiotensin or the vasodepressor response to isoprenaline was not altered. alpha-Adrenoceptor blockade was still evident up to five days after dosing.5. WR-149,024 did not block phenylephrine inhibition of intestinal motility. These findings suggest that WR-149,024 initiates a relatively specific and prolonged alpha-adrenoceptor blockade.


Effects of brocresine (NSD-1055) and cycloheximide on amino acid decarboxylase activities in gastric mucosa of normal and vagally denervated rats. 1. Histidine decarboxylase activity of rat stomach fluctuates depending upon the functional state of the stomach. This varying enzyme activity poses special problems in assessing the effectiveness of enzyme inhibitors. After vagal denervation gastric histidine decarboxylase is markedly activated and remains at a high, stable level, which is unaffected by the functional state of the stomach. Thus it appears that vagally denervated rats are well suited for studies on histidine decarboxylase inhibitors.2. In vivo, brocresine (NSD-1055) was found to be a more effective inhibitor of gastric DOPA decarboxylase than of gastric histidine decarboxylase. With the fairly high dose given (200 mg/kg) the inhibition of histidine decarboxylase was at most 75-85% and quite short-lasting. The DOPA decarboxylase activity, which was not affected by vagal denervation, was inhibited more than 95% by brocresine; this inhibition was longer-lasting.3. Cycloheximide, which probably lowers gastric histidine decarboxylase activity by inhibiting enzyme synthesis, was maximally effective at a dose level as low as 1 mg/kg. Gastric DOPA decarboxylase was not inhibited by cycloheximide. Vagotomized rats and control rats responded similarly.4. Combined treatment of vagally denervated rats with brocresine and cycloheximide resulted in a rapid and persistent reduction of the histidine decarboxylase activity. It is concluded that the failure of brocresine alone to induce a lasting inhibition of histidine decarboxylase is due to continuous, rapid synthesis of new enzyme.5. The calculated half-life of gastric histidine decarboxylase was 75 min in vagally denervated rats and 45 min in normal fasted rats. The results suggest that the increased enzyme activity after vagal denervation is caused by an increased rate of enzyme synthesis.


Antihypertensive therapy with adrenergic beta-receptor blockers and vasodilators.


Studies on the prostaglandin A 2  synthetase complex from Plexaura homomalla.


The histology of autologous skin grafts in the human oral cavity.


Holographic investigation of the elastic deformation of defective gold solder joints.


Aminopyrine demethylase activity in normal and vitamin E-deficient male rats.


Ribitol and flavinogenesis in Eremothecium ashbyii. 1. Supplementation of cultures of Eremothecium ashbyii with ribitol leads to a twofold increase in riboflavin formation compared with unsupplemented cultures or those supplemented with ribose or ribulose phosphate. Addition of unlabelled ribitol decreases the incorporation of [1-(14)C]ribose into riboflavin, indicating that free ribitol is preferred to ribose for incorporation into riboflavin. 2. The enzymes ribitol kinase, d-ribose reductase, d-ribose 5'-phosphatase and GMP nucleosidase were demonstrated in the cell-free extracts. Ribitol induces the formation of ribitol kinase. The enzyme is activated in vitro by the flavinogenic purines, guanine and xanthine. d-Ribose reductase shows a specific requirement for NADPH and forms free ribitol from ribose. 3. The activities of ribitol kinase, ribose 5'-phosphatase and GMP nucleosidase reach their maximal values before riboflavin formation reaches a maximum. 4. [U-(14)C]GMP is taken up intact by the culture of E. ashbyii and is incorporated into riboflavin as well as into a blue fluorescent compound. The radioactivity from this compound is incorporated into riboflavin by the cell-free extract of E. ashbyii.


Inhibition studies on the aromatization of androst-4-ene-3,17-dione by human placental microsomal preparations.


The isocitrate dehydrogenases of Acinetobacter lwoffi. Separation and properties of two nicotinamide-adenine dinucleotide phosphate-linked isoenzymes. Two isoenzymes of NADP-linked isocitrate dehydrogenase have been identified in Acinetobacter lwoffi and have been termed isoenzyme-I and isoenzyme-II. The isoenzymes may be separated by ion-exchange chromatography on DEAE-cellulose, by gel filtration on Sephadex G-200, or by zonal ultracentrifugation in a sucrose gradient. Low concentrations of glyoxylate or pyruvate effect considerable stimulation of the activity of isoenzyme-II. The isoenzymes also differ in pH-dependence of activity, kinetic parameters, stability to heat or urea and molecular size. Whereas isoenzyme-I resembles the NADP-linked isocitrate dehydrogenases from other organisms in having a molecular weight under 100000, isoenzyme-II is a much larger enzyme (molecular weight around 300000) resembling the NAD-linked isocitrate dehydrogenases of higher organisms.


Effect of diet and also physiological state on some enzymes of carbohydrate metabolism in the liver of the domestic fowl.


The microbial metabolism of nitrilotriacetate.


Negative co-operativity in glutamate dehydrogenase: coenzyme-binding studies.


The purification and properties of cyclohexanone oxygenase from Nocardia globerula CL 1.


The type-specific substance from Pneumococcus type 13. 1. The type-specific substance, S.13, from Pneumococcus type 13 was subjected to hydrolysis with alkali, followed by enzymic dephosphorylation, to yield a pentasaccharide. 2. The pentasaccharide, corresponding to the dephosphorylated repeating unit of S.13, was shown to be O-beta-d-galactopyranosyl-(1-->4)-O-beta- d-glucopyranosyl-(1-->3)-O-beta-d- galactofuranosyl-(1-->4)-O-2-acetamido-2-deoxy-beta-d- glucopyranosyl-(1-->2)-ribitol. 3. The phosphodiester linkages in S.13 join the hydroxyl group at position 1 of ribitol and the hydroxyl group at position 4 of a galactopyranosyl residue in the next repeating unit. 4. Ester groups, presumably O-acetyl, are located on positions 2 or 3 of most glucopyranosyl residues in S.13. 5. A partial structure for S.13 is proposed.


-Adrenergic blockers and early stages in liver regeneration.


A study of metabolic control and intracellular transport by multifunctional photon counting and two channel microfluorometry.


On the regulation of tyrosine transaminase, glutamatic dehydrogenase and aspartic transaminase in Tetrahymena.


Purification and properties of nicotinamide mononucleotide amidohydrolase from Azotobacter vinelandii.


Studies on regulatory functions of malic enzymes. II. Purification and molecular properties of nicotinamide adenine dinucleotide-linked malic enzyme from Eschericha coli.


On the reaction of D-amino acid oxidase with  -chloro-D-alanine.


Psychopathy, race, and delay of gratification by adolescent delinquents.


Visual exploratory behavior as a function of manifest anxiety.


Evidence for a transient tetrameric form of glucose 6-phosphate dehydrogenase from human erythrocytes.


Epidemiologic study of dental caries experience and between-meal eating patterns.


Human dental caries experience related to age, sex, race, and certein salivary properties.


Comparative fine structure of Cnidaria spermatozoa.


Acute haemodynamic effects of practolol in patients with idiopathic hypertrophic subaortic stenosis.


Determination of drug metabolizing enzymes in needle biopsies of human liver.


Studies on the elimination reaction of D-amino acid oxidase with  -amino- -chlorobutyrate. Further evidence for abstraction of substrate  -hydrogen as a proton.


Some pharmacologic characteristics of the human vas deferens.


Distrbution of enzymes between nucleus and cytoplasm of single nerve cell bodies.


Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein).


Physician's assistant training program: questions & answers.


Characterization of T7-specific ribonucleic acid polymerase. II. Inhibitors of the enzyme and their application to the study of the enzymatic reaction.


Cardiac complications. Periarteritis nodosa of infancy.


Polyarteritis nodosa--an enigmatic disease.


Grantsmanship in continuing education.

Grantsmanship in continuing education.


Evaluation in continuing education.

Evaluation in continuing education.


Continuing education in nursing.

Continuing education in nursing.


Nurse practitioner: a new program in continuing education.


Continuing education programs in nursing: an exploration.


Training staffs multidimensional perceptions of a class of Medex (physician's extension) trainees: a method of grading.


The undescended testicle.

The undescended testicle.


Pharmacologic principles of gastrointestinal therapy.


Oxidation of reduced triphosphopyridine nucleotide by submitochondrial particles from beef heart.


Release of the "ammonia effect" on three catabolic enzymes by NADP-specific glutamate dehydrogenaseless mutations in Saccharomyces cerevisiae.


Purification and properties of L(+)-lactate dehydrogenase from potato tubers. 1. A purification of l(+)-lactate dehydrogenase is described. 2. The final preparation is active with NADH and NADPH and with a number of keto acids, but evidence is presented to support the view that a single enzyme is involved. 3. NAD(+) showed product inhibition, but at slightly acid pH values there was evidence of co-operative binding. 4. At acid pH values ATP was a potent inhibitor and appears to be an allosteric effector. At neutral or alkaline pH values ATP behaved as a weak competitive inhibitor. 5. The physiological significance of inhibition by ATP is discussed.


Circulation, respiratory volumes and temperature regulation of the pigeon in dry and humid heat.


Effect of stimulators and inhibitors of hydrochloric acid secretion on numbers of oxidoreductase-positive gastric parietal cells in rats.


Weight shifts in the intact turtle during heating and cooling.


Activity recorded from the statocyst nerve of Pleurobranchaea californica during rotation and at different tilts.


Structure-activity relationships of amino acid receptor sites on an identifiable cell body in the brain of the land snail Helix aspersa.


Relationship between duodenal calcium-binding protein, parathyroid activity and various parameters of mineral metabolism in the rachitic and vitamin D-treated chick.


Calorigenic effect of 5-hydroxytryptamine in the frog, Rana temporaria.


Fluid and glucose movement across the small intestine in laboratory mammals.


International Congress on Mental Retardation.


Evolution of the branchial sodium outflux and its components, especially the Na-K exchange and the Na-K dependent ATPase activity during adaptation to sea water in Anguilla anguilla.


The role of adrenal corticosteroids in the regulation of kidney function in the desert lizard Dipsosaurus dorsalis.


Acute effects on hypertonicity on the potential difference across the rumen wall in sheep.


Blood chemistry of Roosevelt elk (Cervus canadensis roosevelti).


The absorption of inulin by cloacas and bladders in reptiles and the chicken.


Placental transfer of iron in the sow (Sus domesticus).


Period of gestation and body weight in some placental mammals.


3-Ketoglucose reductase of Agrobacterium tumefaciens. Two kinds of 3-ketoglucose-reducing enzyme were partially purified from the sonic extract of Agrobacterium tumefaciens IAM 1525 grown on a sucrose-containing medium. Both enzymes have a specific requirement for reduced nicotinamide adenine dinucleotide phosphate (NADPH) as a hydrogen donor and catalyze the reduction of 3-ketoglucose to glucose but do not reduce 3-ketoglucosides such as 3-ketosucrose, 3-ketoglucose-1-phosphate, 3-ketotrehalose, and 3-ketocellobiose. From the requirement and substrate specificity of the enzymes, the name NADPH:3-ketoglucose oxidoreductase (trivial name, 3-ketoglucose reductase) was proposed. By diethylaminoethyl-cellulose column chromatography, two reductases were separated, and the early and late eluted enzymes were designated reductase I and II, respectively. K(m) values of reductase I and II were as follows: for 3-ketoglucose both had an identical value of 2.5 x 10(-5)m, and for NADPH the values were 1.0 x 10(-5)m and 1.5 x 10(-5)m, respectively. Optimal pH values were also identical: pH 4.8 to 5.0 in 10(-2)m phosphate buffer. Intracellular localization of the enzymes is discussed.


Adenosine triphosphate-dependent deoxyribonuclease from Diplococcus pneumoniae: fate of transforming deoxyribonucleic acid in a strain deficient in the enzymatic activity. The adenosine triphosphate-dependent deoxyribonuclease is required for wild-type levels of deoxyribonucleic acid (DNA) repair and genetic recombination. In an attempt to determine the physiological function of this enzyme in pneumococcal transformation, the fate of transforming DNA was followed in a wild-type strain and in a strain lacking the enzymatic activity. The qualitative and quantitative findings were closely comparable in the two strains through the step of physical association of a single strand of donor DNA with the recipient chromosome. These results are interpreted to mean that the enzyme may be involved in the subsequent hypothetical removal of excess polynucleotide sequences during conversion of the presumed hydrogen-bonded intermediate into a covalently linked recombinant structure.


Neuroleptics and neurologic reactions.

Neuroleptics and neurologic reactions.


Effect of  - and  -adrenergic blocking agents and para-chlorophenylalanine on morphine- and caffeine-stimulated locomotor activity of mice.


Mechanism of aromatic nitro group reduction in the soluble fraction of human placenta.


Viral and bacterial neuraminidases.

Viral and bacterial neuraminidases.


Hereditary methemoglobinemia associated with NADH diaphorase deficiency.


Biennial Scientific Congress and 66th annual general meeting, East London, 13-17 September, 1971. Address by the president.


Interactions of psychotropic drugs in the elderly.


Management of respiratory allergy by nonallergists. 2. Asthma.


Tardive dyskinesia: side effect or not?

Tardive dyskinesia: side effect or not?


Comparison of the respiratory chain of Neurospora crassa wild type and the mi-mutants mi-1 and mi-3.


Incorporation of galactose into blood-groups(ABH) precursor substance by lactose synthetase from human milk. Effects on cross reactivity with anti-type-14 pneumococcus serum.


Dihydropteridine reductase. Measurement of dissociation constants for binary complexes of enzyme and ligands.


V Asian Pacific Congress of Cardiology: profile of plenary sessions.


Selective utilization of pyrimidine deoxyribonucleosides for deoxyribonucleic acid synthesis in pneumococcus. When pyrimidine deoxyribonucleosides are supplied to growing cultures of Diplococcus pneumoniae, they are selectively used for incorporation into deoxyribonucleic acid (DNA). Differently labeled molecules of deoxyuridine, thymidine, and deoxycytidine were used to study the precursor pathways of this organism. Each of these preformed pyrimidine deoxynucleosides is incorporated intact (i.e., without cleavage of the glycosidic bond) and is predominantly recoverable as DNA thymidine. During the utilization of deoxycytidine and deoxyuridine by pneumococci, large proportions of the available precursor are converted to free thymidine, which is secreted back into the growth medium. The biochemical pathways for selective incorporation into DNA and the regulation of concentrations of intracellular thymidine compounds by excretion of free thymidine are discussed.