An allotypic specificity presumably of the a series in rabbit immunoglobulins, different from a1, a2, and a3.


Determination of volatile fatty acids in plasma after ethanolic extraction. 1. A new rapid micro-method for measuring plasma volatile fatty acids is described. The volatile fatty acids are extracted from plasma with ethanol in the presence of a known quantity of internal standard (sodium isobutyrate). After evaporation of the ethanolic solution of the sodium salts, the residue is dissolved in a dilute solution of orthophosphoric acid to permit analysis by g.l.c. 2. A technique of g.l.c. analysis is described which permits the separation of all the volatile fatty acids from the other plasma constituents at temperatures below 100 degrees C in 5 min. 3. Steam-distillation techniques are unsatisfactory when the acetic acid concentrations in the plasma are below 0.2mm. Heating of a number of plasma constituents in acid conditions gives rise to acetic acid. 4. The binding of volatile fatty acids to plasma proteins was studied; this binding is negligible for acetic acid, but increases with the length of the fatty acid carbon chain. 5. The limits of use of the method and the physiological implications are discussed.


Lipophilic chelator inhibition of mitochondrial membrane-bound ATPase activity and prevention of inhibition by uncouplers.


Purification of canine antithrombin III-heparin cofactor using affinity chromatography.


Circular dichroism variations among specifically purified rabbit antibodies.


In vitro synthesis of DNA complementary to polyadenylated histone messenger RNA.


Interspecific cross-reactivity of deciduoma antiserum: interaction between mouse deciduoma and antiserum to rat deciduoma.


Willebrand factor and ristocetin. I. Mechanism of rustocetin-induced platelet aggregation.


Histochemical localization of neutral lipid and choline-containing phospholipid in the epididymides of neopuberal Holstein bulls.


Fatty acid composition of tissues in Refsum's disease (herodopathia atactica polyneuritiformis). Estimation of total phytanic acid accumulation.


Metachromasia and human skin fibroblast cultures. The importance of emphasizing the hazards of applying metachromasia as an indication of a specific genetic defect, or as a sole guide for genetic counseling, is discussed.


Adenosine 3'-5' cyclic monophosphate and guanosine 3'-5' cyclic monophosphate: effect on anaphylactic histamine release by rat mast cells.


The use of white blood cell cultures in studying genetic metabolic diseases. Studies of white blood cell cultures in genetic metabolic diseases, in addition to those already in the literature, are reported.


Congenital indifference to pain.

Congenital indifference to pain.


Refsum's disease (heredopathia atactica polyneuriformis).


The metabolic basis of the Refsum syndrome. Studies in patients with the Refsum syndrome show that accumulation of phytanic acid stems from a metabolic error in the pathway for its oxidative degradation. The major degradative pathway involves an initial alpha oxidation followed by successive beta oxidation steps. The enzyme defect in patients with phytanic acid storage appears to be at the very first step, alphahydroxylation of phytanic acid. Heterozygous carriers have a partial fibroblasts in cell culture. On diets low in phytanic acid content, plasma phytanic acid levels fall and objective studies in patients suggest therapeutic benefit.


Heredopathia atactica polyneuritiformis (Refsum's Disease): a second trial of dietary therapy in two patients. Two sibs with heredopathia atactica polyneuritiformis (Refsum's Disease) each had a relapse after ceasing to follow a special diet. On being placed on a very restricted low phytol, low phytanic acid diet both had marked subjective improvement, and marked objective improvement both in physical findings and in quantitative tests of strength, dexterity, and motor nerve conduction velocities, concomitant with a  fall in serum phytanic acid levels. No relapse occurred in 22 months on this diet.


The effects of abate, an organophosphorous insecticide, on marsh fiddler crab populations.


Seasonal changes in organochlorine compounds and mercury in common terns of Hamilton Harbour, Ontario.


The effect of nerve stimulation on the axonal transport of noradrenaline and dopamine-beta-hydroxylase. 1 A method for stimulating the lumbar sympathetic outflow from the spinal cord of the rat is described which does not require artificial respiration of the animal.2 In some, but not all experiments continuous stimulation at 2 Hz or intermittently at 10 Hz accelerated the rate at which noradrenaline and dopamine-beta-hydroxylase accumulated central to a ligature on the sciatic nerve by approximately 40%.3 It is concluded that, although nervous activity is not necessary for axonal transport of transmitter granules in sympathetic neurones, intense nervous activity may accelerate the rate of granule transport.


General discussion concerning the receptor organization.


The stato-acoustic nuclear complex and the nucleus cerebelli of the frog. A golgi study.


Projections of the intraotic ganglion to the medullary nuclei in the tegu lizard, Tupinambis nigropunctatus.


The distribution of primary lagenar fibers within the vestibular nuclear complex of the pigeon.


Cupular structure and its receptor relationship.


Cochlear anatomy of the alligator lizard.


The magnetocardiogram in cardiac disorders.


Immunohistochemical demonstration of a CRF-associated neurophysin in the external zone of the rat median eminence.


On club-shaped neurons establishing part of the deep moiety of layer VI in the human isocortex. A golgi and pigmentarchitectonic study.


Changes in axonal transport in neurones of Asterias vulgaris and Asterias forbesei produced by colchicine and dimethyl sulfoxide.


Short pulses of antigen induce in vitro an antibody response to haptenic determinants.


The mixed-leukocyte reaction in man: effect of pools of stimulating cells selected on the basis of crossreacting HL-A specificities.


Allotypes of anti-alloantibodies.

Allotypes of anti-alloantibodies.


Lymphocyte suppression associated with alpha globulin. Changes in cellular immunity.


Immunosuppressive activity of serum during the development of experimental allergic encephalomyelitis.


Evidence for the presence in unimmunized mice of two populations of bone marrow derived B lymphocytes, defined by differences in adherence properties.


In vitro immune responses: effects of masking lymphocyte membrane components.


In vitro and in vivo immune responses to homologous myelin basic protein in experimental allergic encephalomyelitis.


In vitro suppression of immunoglobulin allotype synthesis by antibody specific for heavy chain determinants.


Interference with tolerance induction in mice by poly A:U.


The effect of Freund's complete adjuvant on the specificity of an immune response, and its relationship to antigenic competition.


Specificity of antibody formation after intravitreal immunization with bovine gamma globulin and ovalbumin. II. Nonspecific enhancement of the secondary response.


Immunological studies on liver diseases in the Mongolian People's Republic. The sera of 445 persons, mainly patients with various liver diseases, were examined for alpha-fetoprotein (AFP) and hepatitis B antigens (HB Ag) and antibodies (HB Ab). The presence of AFP was detected in 9 sera by agar-gel precipitation and in 22 additional sera by the more sensitive aggregate haemagglutination technique. HB Ag proved to be present in 74 sera and HB Ab was present in 34 sera. Hepatitis B antigen was present more frequently (42%) in sera containing alpha-fetoprotein than in sera that did not contain it (14.7%). The food habits of the population investigated were also studied.


Comparison of strip and Ziehl-Neelsen methods for staining acid-fast bacteria. The efficiency of the Ziehl-Neelsen method for staining acid-fast bacteria was compared with that of the strip-staining procedure in which one kind of impregnated strip is used to stain the bacteria and another kind for simultaneous decolorization and counter-staining of the smear. The methods were evaluated in 1 136 duplicate smears prepared from digested sputum and 307 pairs of direct smears. The efficiency of the strip method was comparable to that of the Ziehl-Neelsen method with digested sputum; with direct smears, however, it generally depended on the quality of the smear. With thick, uneven smears, lower bacterial counts were obtained by strip staining. On the basis of this trial, the authors suggest improvement of the strip method.


Hepatitis B virus infection in northern India. Prevalence, subtypes, and seasonal variation. Previous reports from India have been limited to the incidences of hepatitis B antigen (HB Ag) in health and disease. This paper reports on a study undertaken over the last two years to determine the incidence of hepatitis B virus infection, the serotypes prevalent among apparently healthy individuals and patients with liver diseases, and the seasonal incidence of sporadic acute hepatitis in this geographic area. The incidences of infection in health and disease show an endemic pattern. The Y subtype predominates among healthy carriers and patients with chronic liver diseases, whereas the D subtype predominates in patients with acute hepatitis. The similarity of subtypes of HB Ag among the majority of healthy carriers and patients with chronic liver diseases suggests that the majority of asymptomatic carriers (subclinically infected) would develop chronic liver disease. The proportion of HB Ag-positive cases of acute hepatitis was significantly higher during the two summer seasons than during the two winter seasons; this could be due to more frequent transmission of the virus by the faecal/urinary-oral route and its activation during the summer months, especially in areas with poor hygienic conditions. The urinary/faecal excretion of virus could thus maintain the natural transmission of the virus in such an environment.


Sugar absorption by mouse small intestine.


Genetic and biochemical studies of drug resistance in staphylococci.


Biological properties of staphylococcal alpha- and beta-hemolysins.


The staphylococcal enterotoxins: similarities.


Immunological studies in nasal carriers of staphylococci.


Antigen preparations from Staphylococcus aureus.


Present status of the rheumatoid factor.


An assessment of methods used for measuring the recovery of mammalian cells from freezing and thawing.


Cytological evidence for holocentric chromosomes of the silkworms, Bombyx mori and B. mandarina, (Bombycidae, Lepidoptera).


Location, structure and behaviour of C-heterochromatin during meiosis in Dichroplus silveiraguidoi (Acrididae-Orthoptera).


Mechanisms of chromosome banding. III. Similarity between G-bands of mitotic chromosomes and chromomeres of meiotic chromosomes.


Chromosome banding and DNA replication studies on a cell line of Dipodomys merriami.


Heterochromatin and disproportionate chromosome replication in Anatopynia dyari (Diptera: Chironomidae).


Corticosteroids in terminal cancer.

Corticosteroids in terminal cancer.


Distribution of mitomycin C-induced damage in human chromosomes with special reference to regions of repetitive DNA.


The relationship between repetitive DNA and chromosomal bands in man.


Chronic radium intoxication: clinical and autopsy findings in long-term New Jersey survivors.


Hyaline membrane disease in neonates treated with artificial ventilation: neurological and intellectual sequelae at two to five years of age.


Nuclear DNA content and phytohormone requirements of normal, Crown gall and habituated tissues of Nicotiana tabacum var. White Burley.


Semiconservative DNA duplication in human chromosomes treated with BUDR and stained with acridine orange.


Is isolabeling a false image?

Is isolabeling a false image?


Oncorna-viral information in human melanoma.


Human chromosome structure as revealed by an immunoperoxidase staining procedure.


Hodgkin's disease and the liver.

Hodgkin's disease and the liver.


Immunological selection of HL-A variants of cultured progeric fibroblasts and their identification by quinacrine fluorescence.


Gastrointestinal tuberculosis.

Gastrointestinal tuberculosis.


Immunocompetent and immunoneutral inflammatory mononuclear cells.


Serum lysozyme (muramidase) as functional test of granulopoiesis in the course of cytostatic therapy.


Investigations on the antigenic specificity of fibrinogen.


Conclusions from the studies on hepatitis B antigen in blood donors.


Comparative studies of the C cells in the thyroid glands of the domestic pig and cat.


Effect of neuraminidase-treated and mitomycin C-treated polyoma tumour cells on the established tumour growth in CBA mice. I. An attempt at evaluation of polyoma tumour destruction using the distribution of lissamine green method.


Relationship between "desmosomes" and serrations of primary relief of cornifed epidermal cells.


Analysis of reaction lag time to repeated visual inputs in the hyperthyroid patient by using correlation method.


Serum histaminopexy in allergic and non-allergic Indian subjects.


Role of mono-amines in pentylene tetrazol induced seizure in mice.


Different stages of transformation of Rous virus-infected cells evidenced by methylene blue staining.


Banding patterns in chromosomes.

Banding patterns in chromosomes.


Symbolism in a "protest psychosis".

Symbolism in a "protest psychosis".


Computerized chromosome identification by aid of the quinacrine mustard fluorescence technique.


Identification of chromosome bivalents in human male meiosis by quinacrine mustard fluorescence analysis.


Chromosome staining procedure for whole mounts of eggs and early embryos.


The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.


Identification of different Robertsonian translocations in man by quinacrine mustard fluorescence analysis.


Fluorescent pattern of apparently normal chromosomes in Burkitt lymphomas.


Experiments with fluorescent chromosome staining in Burkitt tumors.


Bacteriophage development in lysogenic Escherichia coli and mutations in fungi induced with analogs of tris(1-aziridinyl) phosphine oxide, TEPA.


Chromosome-breaking capacity of TEPA and analogues in Vicia faba and Chinese hamster cells.


The complexity of the fluorescent pattern of the human Y chromosome.


Translocations causing non-fluorescent Y chromosomes in human XO/XY mosaics.


Idiogram and fluorescence pattern of the chromosomes of the Indian muntjac.


Are variations in length of Y chromosome due to structural changes?


Karyotype XX/XY/XXY/XXXY in a Klinefelter patient.


Repetitious DNA in mammalian chromosomes.


Fluorescence study of interphase nuclei and double Y chromosomes.


Fluorochromes and heterochromatin. A study of the chromosomes of Microtus agrestis L.


Fluorescent marker Chromosomes in malignant lymphomas.


The fluorescence pattern of the human karyotype.


Bovine chromosomes identified by quinacrine mustard and fluorescence microscopy.


Banding characteristics of paracentric marker constrictions in human chromosomes.


A case of XX male.--Cytogenetic findings by autoradiography and fluorescence microscopy.


Identification by fluorescence of the G chromosome lost in human meningomas.


Identification of goat chromosomes by the quinacrine mustard fluorescence technique.


Heterochromatin (C bands) in bovine chromosomes.


Differential basophilia of adrenomedullary catecholamine storing granules induced by glutaraldehyde fixation.


Effect of uncoupling agents and respiratory inhibitors on the growth of Streptococcus agalactiae. 2,4-Dinitrophenol, dicoumarol, carbonylcyanide, m-chlorophenyl-hydrazone and pentachlorophenol all depressed aerobic molar growth yields of Streptococcus agalactiae to values equal to, or less than, those supported by substrate level phosphorylation. When the only source of energy was from substrate phosphorylation (anaerobic growth conditions), there was also a severe depression of the molar growth yield by the same four uncoupling agents. These results indicate that the effect of these agents is to uncouple both substrate and oxidative phosphorylation in S. agalactiae. Amytal inhibited glucose utilization, reduced the amount of O(2) used per mole of substrate and reduced the molar cell yield to that supported by substrate phosphorylation. Atebrin inhibited the respiration rate, but final O(2) consumed per mole of substrate was unchanged, and the respiration was coupled to biosynthesis. Rotenone had no effect on respiration, substrate utilization, or on molar growth yields.


Incompatibility in Podospora anserina: comparative properties of the antagonistic cytoplasmic factors of a nonallelic system. In the fungus Podospora anserina, the interaction between the nonallelic incompatible R and V genes has two consequences: a lytic reaction due to the synthesis of specific proteolytic enzymes, and a quenching in protein and ribonucleic acid synthesis. The incompatibility reaction when vegetative or sexual R and V cells fuse is asymmetric: it is induced only in the R protoplasm. The cessation in ribonucleic acid and protein synthesis was investigated in heterokaryotic strains carrying the antagonistic R and V genes and their "neutral" r and v alleles. Asymmetry between R and V genes lies in the fact that the strains homozygous for the R genes are the only strains that cannot grow. From these results it is postulated that the V-gene product is a diffusible cytoplasmic factor and that the R-gene product, which is nonautonomous, is a ribosomal component.


Antigenic difference between polar montrichous and peritrichous flagella of Vibrio parahaemolyticus. Polar monotrichous and peritrichous flagella of Vibrio parahaemolyticus were isolated and purified separately. On hydroxylapatite column chromatography, the flagellins of polar monotrichous flagella were eluted with a higher concentration of phosphate than those of peritrichous flagella. Gel diffusion tests showed an antigenic difference between the flagellins of polar monotrichous and peritrichous flagella. Electron microscope observations on cells stained with ferritin-conjugated antibodies demonstrated that polar monotrichous and peritrichous flagella reacted specifically with antimonotrichous flagellin and antiperitrichous flagellin antisera, respectively.


Action of lysozyme on penicillin-induced filaments of Proteus vulgaris. Penicillin-induced filaments of Proteus vulgaris P 18 had a seemingly unaltered cell envelope. Lysozyme, however, reduced the wall part of these filaments into a three-layered structure and caused transformation into spheroplasts. Although cross walls and membrane septa were absent in the filaments, most of the lysozyme-induced spheroplasts remained attached to each other.


Characterization of specific antibodies to phenobarbital.


Isolation and characterization of bacteria that grow on methane and organic compounds as sole sources of carbon and energy. Bacteria capable of growth on methane and a variety of complex organic substrates as sole sources of carbon and energy have been isolated. Conditions used to rigorously establish the purity of the cultures are described. One facultative methylotroph has been studied in detail. This organism has peripherally arranged pairs of intracytoplasmic membranes characteristic of obligate methylotrophs. This isolate apparently utilizes the serine pathway of formaldehyde fixation. The location of methane oxidizers in a dimictic lake indicates that these organisms prefer less than saturating levels of dissolved oxygen. Laboratory experiments confirmed the preference of these organisms for atmospheres containing less oxygen than air.


The diphtheroid agent of ovine posthitis: its relationship to Corynebacterium renale.


The possible viral aetiology of disseminated sclerosis.


A biochemical study of experimental Johne's disease. I. Plasma protein leakage into the intestine of sheep.


Purification of anti-dinitrophenyl antibodies and their fractionation according to affinity.


Alpha-lipoprotein heterogeneity in serum of mammals.


A need for critical evaluation of automatic microtitration machines.


Preparation of sensitive and stable erythrocytes by the carbodiimide method for the detection of primary and secondary IgM and IgG antibody.


Ultrastructure of tracheal cilia during degeneration by sulphurous anhydride and exhaust gas.


Differential cellular increase in cerebrospinal fluid after encephalography in mentally retarded patients. The behaviour of the CSF cells during gas encephalography (GEG) with O(2), N(2)O, and halothane is poorly known in cerebral developmental disorders. One hundred and fifty CSF samples taken during pneumoencephalography from 75 mentally retarded patients were examined cytologically by the millipore technique with Papanicolaou staining. The results were processed automatically. An approximately 25-fold increase in CSF cells (P<0·001), mainly meningeal, reticulohistiocytic, and monocytic types, was found to occur. The cortical gas filling rate had a positive correlation (P<0·001) with the increase of number of CSF cells. There were no significant differences between the cellular changes in different cerebral disorders. Thus, though the irritant effect of GEG gives a rich cell yield, diagnostic atypical cells in developmental disorders of the central nervous system probably rarely exfoliate into the lumbar CSF.


Proceedings: A method for the quantitative estimation of gastric barrier mucus.


The effect of various disclosants on plaque accumulation in human subjects.


Effects of Corynebacterium parvum and Freund's adjuvants on amphibian antibody responses.


The effect of thyroid function on experimental cutaneous calcification in the rat.


A histochemical approach to the cholinergic innervation of endocrine-like cells in dog antro-pyloric mucosa.


Electron microscopical studies on the renal arteriole in hypertensives and non-hypertensives. II. Renal arteriole in non-hypertensives.


Fire as a symbol and as a weapon of death.


Proceedings: On the conversion of tryptophan into 2-thiol-tryptophan, via thiolysis of the dinitrophenylsulfenyl derivative.


Concentrations in virto of various enzymes in liver homogenates during the first few days of a period of starvation.


Protoplasmic incompatibility and female organ formation in Podospora anserina: Properties of mutations abolishing both processes. A genetic block, effective only with the addition of mutations in two genes, suppresses both the incompatibility process in strain confrontation ("barrage") and the formation of female organs. Investigation on this block lead us to propose that it operates at the ribosomal level and prevents the translation of the messenger of a proteolytic enzyme, a postulated early protein in protoperithecia differenciation.


Effects of compound 48/80 on mast cells, histamine, and cyclic AMP in isolated superior cervical ganglia.


Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology.


Studies on the bacterial spore coat. 5. Effect of sodium dodecyl sulphate sonic treatment on the spore of Bacillus thiaminolyticus.


Trypanosoma (Schizotrypanum) dionisii of pipistrellus pipistrellus (chiroptera): intra- and extracellular development in vitro.


Similitudes and differences in the reactivity of the liver cell chromatin to thioacetamide and hydrocortisone. Electron microscopic and cytochemical quantitative data concerning the chromatin condensation-dispersion cycle. The administration of thioacetamide (TAA) and/or hydrocortisone to rats brought about dispersion of the heterochromatin in the liver cell, and concomitant stimulation of RNA synthesis in the chromatin. In contrast to other experimental situations in which dispersion of the chromatin persisted for at least 6 hours, after TAA injection dispersion was followed by rapid excess condensation. A hypothesis is suggested concerning the process of induction of malignant proliferation by TAA.


The miracle of corneal transplant surgery.


Prenatal diagnosis.

Prenatal diagnosis.


Uses and limitations of gammaglobulin therapy (literature review).


Role of nutrition in the drug-metabolizing enzyme system.


Etiologic agents of immune-deposit disease.


Autoimmunity in liver diseases.

Autoimmunity in liver diseases.


Human gamma-g subclasses.

Human gamma-g subclasses.


Ultrastructural localization of carbohydrate in the hymenium and subhymenium of Coprinus. Evidence for the function of the Golgi apparatus.


Selective uptake of specifically purified antibodies to carcinoembryonic antigen of human adenocarcinoma.


Platelet stain preventing factor in serum or plasma--an early sign of leiomyosarcoma?


The formation of antibodies against hidden determinants of autologous IgG during immunization of rabbits with Staphylococcus aureus.


The influence of epitope density on the immunological properties of hapten-protein conjugates. III. Induction of hapten-specific tolerance by heavily and lightly hapten-substituted serum albumin.


Rheumatoid arthritis and cancer arthritis. II. A total of 394 patients with rheumatoid arthritis were followed-up over a 10-year period from 1963 to 1973, particularly with reference to the aetiological circumstances and in particular, cancer. Cancer was found as cancer arthritis in 50 cases (13 percent) at a stage where it was not possible to find focal cancer symptoms. No definite difference was found in the clinical course of the rheumatoid arthritis, no matter the varying aetiology, A series of statistically significant differences in the laboratory values for rheumatoid arthritis and cancer arthritis, respectively, are indicated and discussed. For that matter, the above observations are not original, in spite of what has been claimed, as Uncle Vanja in the play of the same name by Chekhov says: "They say that Turgenev got cancer as a result of his arthritis."


Same idiotype of B-lymphocyte membrane IgD and IgM. Formal evidence for monoclonality of chronic lymphocytic leukemia cells.


Florid keratoacanthomas in a kidney transplant recipient. Case report.


Ades mosquito surveillance in the republic of Vietnam.


Variability of heparin preparations in clinical use.


Hazards of anticoagulant treatment: other drugs, other diseases.


Measurements of size and weight of prostate by means of transrectal ultrasonotomography.


Experimental infection with Mycoplasma pneumoniae in the young hamster: location of ferritin-labeled antibody binding to infective tissue.


Fractionation of bulldog ant venom.

Fractionation of bulldog ant venom.


Color differences in heated and Giemsa stained mouse chromosomes.


Rapid single-solution polychrome staining of semithin epoxy sections using polyethylene glycol 200 (PEG 200) as a stain solvent.


Staining pollen nuclei with Snow's alcoholic hydrochloric acid-carmine.


A modification of the Glees silver impregnation for normal and degenerating nervous tissue.


Embedding of myelinated nerve tissue in water-soluble resorcinol-formaldehyde resins for light and electron microscopy.


Prevention of chemography in prestained epoxy autoradiographs by an intervening carbon film.


Poststaining sections for electron microscopy.


Iron alizarin blue S stain for nuclei.

Iron alizarin blue S stain for nuclei.


A rapid method to demonstrate muscle cross-striations with thionin.


Thiosulfation aldehyde fuchsin (TAF) procedure for the staining of pancreatic B cells.


Embedment of swimming cells in thin, removable epoxy films without centrifugation, encapsulation, or filtration.


A method for retaining tissue sections on slides.


Epon-embedded tissue stained with aldehyde-fuchsin for radioautography.


A simplified resectioning technique.

A simplified resectioning technique.


Simultaneous staining of the spindle apparatus and constitutive heterochromatin.


Hematoxylin substitutes: gallein as a biological stain.


Mordant blue 3: a readily available substitute for hematoxylin in the routine hematoxylin and eosin stain.


Batch variations in commercial dyes employed for Romanowsky-type staining: a thin-layer chromatographic study.


Further considerations on a simple histological method for identification of osteoid matrix.


Double embedding again.

Double embedding again.


Glycol methacrylate in light microscopy: a routine method for embedding and sectioning animal tissues.


Differentiation of type II alveolar cells--a new use for the Cason stain.


Foley catheter in intracardiac perfusion.


Effect of sodium sulfite purity on color of Bodian silver staining of insect central nervous systems.


Immunogenicity of Entamoeba histolytica antigen fractions.


Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages.


Bacteriology of tuberculosis.

Bacteriology of tuberculosis.


The relationship between humoral and cell-mediated immunity.


Pulmonary tuberculosis: chemotherapy programmes and regimens of chemotherapy.


Lindane residues in the southern coastal aquifer of Israel.


Experimental infection by respiratory route of non-immunized mice exposed to atmosphere contaminated by auto exhaust.


Increased aromatics in motor fuels: a review of the environmental and health effects.


Nature of the antigammaglobulin activity in cryoglobulinemic disorders.


Ultrastructure of developing cartilage in the mandibular condyle of the mouse.


Accumulation and autophagic degradation of glycogen in the mouse cervicovaginal anlage. With remarks on epithelial heterophagy.


The localization within the dorsal motor nucleus of the vagus in the buffalo (Bubalus bubalis).


Changes in aminopeptidase activity in the palatal mucosa and gingiva of the rat following tooth extractions.


Radioimmunological and autoradiographical studies on the alpha-1-fetoprotein in the obstetrics and gynecology.


Extracapillary glomerulonephritis. A semiquantitative lightmicroscopical study of 59 patients.


Glomerular ultrastructure in extracapillary glomerulonephritis.


Immunological properties of two fetus-specific globulins of rat in experimentally induced hepatic lesions.


Combination chemotherapy with anticancer agents and OK-432.


Studies on the host-mediated action of the streptococcal preparation, OK-432, in cancer chemotherapy.


Histochemical observations on the excretory system of digenetic trematodes.


The role of macrophages in defense against neoplastic disease.


Principles of immunological tolerance and immunocyte receptor blockade.


The influence of zinc ions administered in vivo on guinea pig anaphylaxis.


Envelope protein alterations in a conditional mutant of Klebsiella pneumoniae with pH dependent morphology and temperature dependent division.


Recent developments in control of blackflies.


Lymphomatoid papulosis. An ultrastructural study of 2 cases.


Isolation of a specific plasmacytoma tumor antigen, reactive both in humoral and cell mediated immunity.


Human immunoglobulin light chain subgroups: serological typing.


The connnective tissue in the middle ear mucosa of the guinea pig.


Structure and specific antigens of avian leukosis viruses.


The role of genetics in Gross virus leukemogenesis.


Changes at the membranes of leukosis virus transformed cells and virus as detected by electronmicroscopy.


Suppression and patterns of recovery of serum immunoglobulins in mice treated with antibody directed against the constant region of heavy chains.


Physical alterations of a murine leukemia virus complex in mammalian cell cultures.


Transformation of a cloned renal epithelial cell line by Moloney murine sarcoma virus (M-MSV).


The thymus glands and lymphosarcoma in the pike, Esox lucius L. (pisces; esocidae) in Ireland.


Host-virus interactions in murine mammary carcinogenesis.


Organization and communication in populations of normal and leukemic hemopoietic cells.


Chromosomal abnormality (46,XX,3p plus) in a case of the Meckel syndrome.


Updating advances in cytogenetics.

Updating advances in cytogenetics.


An in vitro system for studying the spontaneous occurrence of trisomics.


Focal differences in lipid metabolism of the young pig aorta. Synthesis from [1-14C]acetate and [U-14C]glucose in vitro.


Updating advances in cytogenetics. Applications of the new chromosome banding methods.


Quantitative method for the evaluation of atherosclerotic lesions.


The axonal transport of (3H)fucose labelled glycoproteins in normal and regenerating peripheral nerves.


The location of the positions of the breakpoints involved in the T26H and T70H mouse translocations with the aid of Giemsa-banding.


Chromosomes of the Mexican plateau mouse, Peromyscus melanophrys, and a new sex determining mechanism in mammals.


Significance of coupling intervals of ventricular extrasystoles. Extrasystoles may have fixed or variable coupling intervals. The latter may be divided into those with coupling intervals related to and following the T wave of the preceding QRS (approximate coupling) and those which occur throughout electrical diastole with no obvious relationship to the T wave of the dominant rhythm (random coupling). Extrasystoles with random and approximate coupling may or may not be parasystolic. The relationship of extrasystoles to the dominant rhythm may alter. In particular, fixed coupling may precede or alternate with approximate coupling. These groups cannot be considered distinct, in view of transitions from one type of extrasystole to another. Extrasystoles with both approximate coupling and fixed coupling tend to occur just after the T wave and often occurred on the apex of the U wave. Approximate non-parasystolic coupling was infrequent in electrocardiograms which were otherwise normal. Random non-parasystolic coupling and parasystole only occurred in patients with cardiac disease. In view of these findings, it is proposed that extrasystoles should be described by their degree of dependence on each other (regularity of interectopic intervals) and their degree of dependence on conducted beats (regularity of coupling intervals),


Ventriculo-atrial conduction associated with ventricular premature beats. Study with his bundle electrography. In a group of eight patients with ventricular premature beats, ventriculoatrial conduction, with retrograde activation of the His bundle and the atria could be demonstrated by His bundle electrograms in four subjects. All had early ventricular premature beats with coupling indices between 210 and 350 msec. In the other four cases, concealed retrograde conduction could be demonstrated in the A-V nodal area. The ventricular ectopic beats were late, and depending upon the refractory period of the A-V node these extrasystoles were interpolated or followed by compensatory pauses.


The aesthetes of chitons. II. Fine structure in Lepidochitona cinereus (L.).


Cellular aspects of tolerance. III. The responsiveness of T cells from tolerant donors after exposure to a cross-reacting antigen.


Rat B cells: identity of immunoglobulin-bearing cells with a population of lightly uridine-labeled cells.


Cellular aspects of tolerance. IV. Strain variations of tolerance induceability.


Experimental allergic encephalomyelitis and cellular immunity in the Lewis rat.


Cellular aspects of tolerance. VI. The effect of age on responsiveness and tolerance induceability of SJL mice.


Cellular aspects of tolerance. VII. Inheritance of the resistance to tolerance induction.


Cellular aspects of tolerance. V. The in vivo cooperative role of accessory and thymus derived cells in responsiveness and unresponsiveness of SJL mice.


Cellular analysis of the phenotypic correction of the genetically controlled low immune response to the polyproline determinant by macrophages.


Influence of heparin and protamine on enlargement of the draining lymph node during induction of EAE.


Effect of rabbit interferon on immune responses.


Experimental allergic encephalomyelitis: changes in growth and proliferation within the draining lymph node following injection of basic encephalitogenic protein in Freund's complete adjuvant.


Immune protection against experimental autoimmune encephalomyelitis: optimal conditions and analysis of mechanism.


Antigen modulation of the immune response. III. Evaluation of the hypothetical short-lived memory cell.


Surface immunoglobulin on rabbit lymphoid cells. II. Ultrastructural distribution of b4 allotypic determinants and morphology of spleen lymphocytes.


Surface immunoglobulin on rabbit lymphoid cells. I. Ultrastructural distribution and endocytosis of b4 allotypic determinants on peripheral blood lymphocytes.


Comparative study of histamine release by cotton dust from the lung of several species.


Which antibiotic for acute otitis media?


Radioisotope studies in thyrotoxicosis at Mulago, Kampala.


Long-term administration of 3,5-diodo-4(3'-iodo4'-acetoxyphenoxy) benzoic acid (acetiromate) in hyperlipidemic patients.


Quantitation of ovalbumin mRNA in hen and chick oviduct by hybridization to complementary DNA. Accumulation of specific mRNA in response to estradiol.


Studies on the acute and long-term oral toxicity fo chlorpyrifos (0,0-diethyl-0(3,5,6-trichloro-2-pyridyl) phosphorothioate).


Monographs on fragrance raw materials.

Monographs on fragrance raw materials.


Comparative studies on human and rabbit exocrine IgA antibodies to an albumin.


Experimental allergic encephalomyelitis: structural specificity of determinants for delayed hypersensitivity.


On the mechanism of hemolytic plaque inhibition.


Circadian rhythms: some examples and comments on clinical application.


Effect of haptoglobin on immunological activity of hemoglobin.


Distribution of antibody affinities. II. Fractionation of antibody with respect to its hapten binding affinity.


Antigenic homology between a marsupial homocytotropic antibody and human IgE.


Immunological unresponsiveness induced in adult mice to synthetic polypeptides built on multichain polyproline and multichain polyalanine.


The separation of rabbit anti-dinitrophenyl IgG antibodies on the basis of combining site depth.


Naturally-occurring antibodies reacting with some buried determinants of homologous IgG exposed by spleen protease digestion.


Critical antigenic determinants for production of antibody to distinguish morphine from heroin, codeine and dextromethorphan.


Enzymic and immunochemical properties of lysozyme--VIII. Modification of two carboxyl groups and their role in the antigenic reactivity.


The anti-I activity of the Sophora japonica lectin.


Released myelin basic protein: the immunogenic factor?


Allotypic marker of kappa light chains of rat immunoglobulins localized in the constant region of the chain.


The immunochemistry of a linear polymer and a branched copolymer containing the sequence Glu-Lys-Ala-Gly.


A radioimmunoassay specific for the antigenic determinants exposed by pepsin digestion of human immunoglobulin G.


An immunoenzymatic method for measuring low concentrations of antigens by single radial diffusion.


Allotypes of rat immunoglobulins. II. Distribution of the allotypes of kappa and alpha chain loci in different inbred strains of rats.


Transplantation immunity to individually unique antigens of chemically induced bladder tumors in mice.


Report of the workshop on the carcinoembryonic antigen (cea): the present position and proposals for future investigation.


Control of normal differentiation of myeloid leukemic cells. V. Normal differentiation in aneuploid leukemic cells and the chromosome banding pattern of D+ and D minus clones.


Natural expression of feline type-C virus genomes, prevalence of detectable felv and RD-114 GS antigen, type-C particles and infectious virus in postnatal and fetal cats.


Fetal proteins occurring in testicular teratomas.


Influence of 5-bromodeoxyuridine on the expression of avian gs antigen in mammalian rous sarcoma virus-transformed cells.


Immunogenicity, antigenicity and mechanisms of tumor rejection of mineral-oil-induced plasmacytomas in syngeneic BALB/c mice.


Specific and non-specific immunologic reactivity of regional lymph-node lymphocytes in human malignancy.


Cellular immune response to virus-specific antigen in hamsters bearing isografts of cytomegalovirus-transformed cells.


Report of the scientific meeting on some developments in the methodology of controlled clinical trials in cancer.


Demonstration of Epstein-Barr virus-associated nuclear antigen in nasopharyngeal carcinoma cells from fresh biopsies.


Cell surface antigen induced by avian tumor viruses in hamster cells transformed by a temperature-sensitive mutant of Rous sarcoma virus.


Distinctive properties of thymidine kinase isozymes induced by human and avian hepresviruses.


Specific tumor-induced suppression of lymphocyte activity in the antibody-dependent tumoricidal reaction.


The antigenic determinants of several human plasma proteins. Their determination from the investigation of the cross-reactions between human and other mammalian plasmas.


Antigenic activity of hemeundecapeptide and hemeoctapeptide obtained from cytochrome c.


Characterization of a human pathological immunoglobulin fragmenting during purification.


Studies on inherited antigenic variation of human serum beta-lipoprotein by passive hemagglutination. I. Methodological studies.


Binding of folic acid to serum proteins. IV In some animal species.


Morphological criteria for the control of carcinoma of the prostate with estrogen therapy.


Standards of karyology for human diploid cells.


Identification of some HBAg (HAA) antigenic determinants by two-dimensional electro-immunodiffusion.


Needle Myopathy--An Experimental Study.

Needle Myopathy--An Experimental Study.


The course of a model cutaneous inflammation in the scapuloperoneal syndrome and in systemic neuromuscular diseases.


Histochemical study of Erythema nodosum leprosum (ENL) lesions. A histochemical study of ENL lesions was performed on skin biopsies from 14 leproma-tous patients. There was: 1) the presence of moderate amounts of PAS positive diastase resistant materials, acid mucopolysaccharide, neutral fat, phospholipid, aryl sulfatase and acid phosphatase in areas around and away from reactional sites; 2) the presence of slight amounts or complete absence of these materials within areas of acute inflammation. These changes were interpreted as the result of solubilization and leakage of hydrolytic enzymes into the surrounding tissue. A possible role of lysosomal enzymes in the pathogenesis of ENL lesions is discussed.


Neurology in India.

Neurology in India.


Acid mucopolysaccharide metabolism in leprosy. 1. Storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy. A histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. In contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. The macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tuberculoid in BT cases and the lepromatous expression in BL cases. It is suggested that hyaluronic acid, in a manner similar to M. leprae and lipid, has a quantitatively varied distribution reflecting the immunopathologic spectrum of leprosy. This finding suggests that acid mucopolysaccharide may be significantly involved in that host/parasite interaction in leprosy.


In vivo LE cell formation in peritonitis due to systemic lupus erythematosus.


Gamma globulin complexes in rheumatoid arthritis and hypergammaglobulinemic purpura.


The antigenicity of polynucleotides in mink, rabbit, and man.


Treatment of primary liver carcinoma.

Treatment of primary liver carcinoma.


A macroscopic study of plaque morphogenesis.


Developmental assessment of the young child in general practice.


Electron microscopic observations of heat-induced changes in the structure of mitochondrial membranes.


Human muscle nerve sympathetic activity in cardiac arrhythmias.


Neutral proteases of human granulocytes. III. Interaction between human granulocyte elastase and plasma protease inhibitors.


Liver pathomorphology in collagenoses.

Liver pathomorphology in collagenoses.


Analytical polyacrylamide-gel electrophoresis of aqueous Trypanosoma cruzi extracts. I. Chemical and immunological investigation of Y and Brasil strains antigenic components.


Effect of lobectomy on some parameters of iodine metabolism.


Effect of thyroidectomy on the in vitro utilization of glucose by hypophysis and hypothalamus in the rat.


Histologic study of the skin of congenitally athymic "nude" mice.


Pioneering audio-visual communication in medical education in Nigeria.


Sheep progressive pneumonia virsuses: "slow" cytolytic agents with tumor virus properties: A review.


Immunoflorescence studies of Leishmania enriettii infection in the guinea pig.


Quantitative polyacrylamide gel electrophoresis for cationic proteins from polymorphonuclear (PMN) leukocytes.


Indulin nigrosin elastin stains. Elastin VI. Stains with alcohol-soluble nigrosins and water soluble indulin and nigrosin and their mechanisms: a lipoprotein component?


Nature of protein component of the cuticle of an arachnid, Palamneus swammerdami.


Fixation of mammalian liver in concentrated buffered neutral formaldehyde at different temperatures.


Organization of the myelinated nerve fibres in the iris of the White Leghorn hen.


Choledochoduodenal junction in the dromedary.


Furunculosis in dogs. Aetiology, pathogenesis and treatment. A clinical study.


The genetic mechanisms that control the immune response and antigen recognition.


The action of propanidid on blood histamine content.


The role of thymocytes and bone marrow cells in the genetic control of immune responsiveness to synthetic polypeptides.


Inheritance of fine-specificity in mouse anti-hapten antibodies.


Genetics of the immune response in inbred and random bred mice against random copolymers of amino acids.


Relation of human blood-groups MN to cancer cell surface antigens and to receptors for oncogenic viruses. It has been shown by us that the human blood-group MN antigenic determinants are not the products of allelomorphic genes as believed so far, but that N is the precursor substance of M and that the allelomorph to the M gene is amorph. The determinant structure of the N antigen is branched and possesses as non-reducing termini beta-d-galactopyranosyl (Gal) and alpha-N-acetylneuraminic acid (NANA) linked to beta-Gal. The M substance differs from N only in that alpha-NANA covers the terminal beta-Gal of the N determinant. Vicia graminea anti-N reacts with terminal beta-Gal of the N antigen as well as its precursor. A human blood-group N-like antigen in the cell surface of the TA3 mammary adenocarcinoma (ascites form) has been found by us. The TA3 cancer occurs as the non-strain specific Ha subline and as the strain-specific St subline. This is the first description of an N-like antigen in a non-primate as well as a tumor. This antigen reacts with Vicia anti-N. In serological specificity the Vicia agglutinin is closely related to the Thomsen-Friedenreich anti-T agglutinin present in most human and animal sera. These sera plus complement kill ordinary TA3-St cells and sialidase-treated Ha cells to less than 95 percent. Untreated TA3-Ha cells are fully resistant even though they absorb cytotoxin. Beta-galactosidase treatment of either Ha or St cells abolishes the killing activity of the sera. The cancer cells absorb anti-T but they lose this capability after exposure to beta-galactosidase. An immunological cross-relationship between the human blood-group MN antigens and the receptor for an oncogenic virus, the avian subgroup B leukosis sarcoma virus has been observed.


The significance of alpha-fetoprotein in the serum of patients with malignant teratomas and related gonadal neoplasms. Sera from eleven patients with gonadal germ cell tumors were tested for alpha-fetoprotein (AFP) by counterelectrophoresis. Ovarian neoplasms containing either the endodermal sinus tumor (EST) or dysgerminoma and half of the testicular embryonal carcinomas elaborated the protein into the serum. The presence of AFP in the serum seemed to correlate with early metastasis or a fatal outcome. That the highest levels of AFP were found in cases of EST was in keeping with the theory that the tumor originates in cells of the yolk sac, a principal embryonic site of AFP synthesis.


Differentiation of the cells which synthesize the immunoglobulins.


Role of the cells which originate from the thymus and bone marrow.


A comparison of specific antibody and immunoglobulin synthesising immunocytes in peroxidase stimulated lymph nodes.


Lymphocyte commitment to Ig allotype and class.


Surface-bound immunoglobulin on B-lymphocytes, evidence for allelic exclusion.


Variability of immunoglobulins.

Variability of immunoglobulins.


Subgroups, homologies and idiotypes in immunoglobulins.


On the effect of selective breeding for specific antibody clones in rabbits.


Inheritance of idiotypic specificities of rabbit antibodies to group C streptococci.


Towards a network theory of the immune system.


Allogroups of rabbit Ig heavy chains.

Allogroups of rabbit Ig heavy chains.


Three new examples of intragenic hybridization among IgG subclass genes.


Mouse immunoglobulin allotypes: characterization and use in cellular immunology.


Allotypy and structure of immunoglobulins.


Allotypes of light chains of rat immunoglobulins.


Peptides with a-locus allotypic determinants.


Chemical studies of the heavy chain of rabbit IgG lacking group a allotypic markers.


The interaction of actinomycin with DNA.


Studies on the mechanism of 5-fluoroorotic acid inhibition of serine dehydratase induction.


Complications following the early treatment of hand injuries: an analysis of 100 cases.


The results of radical excision of oral and oropharyngeal cancer requiring pedicle flap reconstruction.


Cancer of the rectum: the results of radical resection and the suggested role of lesser procedures in selected cases.


Improvement of specific fluorescence in the indirect fluorescent antibody method for detecting antinuclear antibodies using Evans blue dye as a counterstain.


The treatment of benign prostatomegaly by injection.


Autosomal polymorphisms.

Autosomal polymorphisms.


The supernumerary isochromosome 18 syndrome (+ 18pu).


Area Health Education as the foundation for a statewide biomedical communications network. In 1972, the Medical University of South Carolina was awarded a contract to establish four Area Health Education Centers in South Carolina. These centers, based in community hospitals, provide residency programs and clinical instruction for medical, dental, nursing, pharmacy, and allied health students and continuing educational programs for health professionals. A plan for delivering library and other information services to the designated Area Health Education Centers is described.


The Library Resource Project Grant at the Muhlenberg Hospital Library.


Development of the self-instructional materials Learning Resources Center.


Cancer viruses.

Cancer viruses.


The gorilla karyotype: chromosome lengths and polymorphisms.


Effect of nercuric chloride on cellular morphology and acid phosphatase of tissue culture cells cultivated in suspension.


Is there a factor in sera from cancer patients that inhibits lymphocyte response to phytohaemagglutinin?


Feulgen hydrolysis of normal and leukemic blood cells.


Blood serum vitamin A and beta-carotene in marasmic Egyptian infants.


Rapid phospholipid test for fetal pulmonary maturity.


Protective effect of formate on GSH concentration and Heinz body formation: a preliminary model study.


Homologous of the human A-B-O blood groups in apes and monkeys.


The HL-A system genetics, (patho)physiology and clinical relevance.


The role of the antibody in immunological cell triggering processes.


Functional properties of T and B lymphocytes in cell-mediated immunity.


The clinical use of plasma fractions.

The clinical use of plasma fractions.


Preparation of specific immunoglobulin for the prevention of hepatitis B.


Haemopoietic precursor cells in early human embryos: light microscopic pictures.


Proceedings: Further studies on the third component of human complement: protein variants and C3 concentration in certain diseases.


Proceedings: Criteria of viability of isolated liver cells.


Proceedings: Inhibition of mouse leukemia virus RNA-dependent DNA polymerase by 2'-OH-substituted polynucleotides.


Three-dimensional reconstruction of individual negatively stained yeast fatty-acid synthetase molecules from tilt series in the electron microscope.


Florometric histamine determination in canine plasma under normal conditions, following application of exogenous histamine, and during histamine release by haemaccel.


Papovavirus structural polypeptides: comparison of human and rabbit papilloma viruses with simian virus 40. A comparative study of the structural polypeptides of purified human papilloma virus, rabbit papilloma virus, and simian virus 40 (SV40) was performed by electrophoretic analysis on 10% polyacrylamide gels containing sodium dodecyl sulfate either by Coomassie blue staining or by electrophoresing purified virus preparations labeled with radioactive iodine. Analysis of human papilloma virus on stained gels revealed 6 bands with a major polypeptide of molecular weight 63,000 daltons comprising 60% of the virion protein. Analysis of rabbit papilloma virus on stained gels revealed 5 bands with a major polypeptide of molecular weight 60,000 daltons comprising 48% of the virion protein. Under conditions which yielded 6 polypeptides for SV40, in agreement with published data, 4 and 7 polypeptides were regularly detected in iodinated preparations of human and rabbit papilloma viruses, respectively. Isoelectrofocusing of iodinated virions revealed isoelectric points of pH 3.7 for SV40 and pH 4.0 for both rabbit and human papilloma viruses.


The case for a family of reverse transcriptase viruses: Retraviridae.


Antibody to the type 5 adenovirus hexon polypeptide: detection of nascent polypeptides in the cytoplasm of infected KB cells. Antibody to type 5 adenovirus hexon polypeptides reacted with the isolated hexon polypeptide chanis (monomers) but not with the native multimeric hexon capsomers (trimers). Indirect immunofluorescence detected hexon polypeptides mainly in the cytoplasm of KB cells infected with types 2 and 5 adenoviruses. Cells infected with adenovirus mutants H5ts116 or H5ts115, which are defective in the production of immunologically detectable hexons, synthesized immunologically detectable hexon polypeptides at the nonpermissive temperature.


[Progress in small animal reproductive physiology, therapy of reproductive disorders, and pet population control].


Synthesis of the pentapeptide sequence 105-109 and smaller fragments of human encephalitogenic protein containing the arginine residue 107.


The caudate nucleus of the rat: cell types and the demonstration of a commissural system.


Intermittent parasystole with concealed bigeminy.


A review of lamination in area 17 of the visual cortex Macaca mulatta. This paper develops a concordance of methods for designating laminae in the primate striate cortex. The classic notation schemes of Ramón y Cajal, Brodmann, and von Bonin and four recent modifications are described in words and photomicrographs. The recent trend toward adopting a lamination scheme that effects a division of cells into recognizable layers and at the same time reflects their connections is considered. Since a single, consistent plan for lamination of the visual cortex would facilitate communication among investigators, it is suggested that Brodmann's original scheme be followed as the most generally useful and applicable.


Meynert cells in the primate visual cortex. The solitary cells of Meynert are distinguished by their specific location in layer V of the striate cortex, very large size, argyrophilia, and the profusion of neurofilaments in their dendrites and perikarya. They occur with greater frequency in the macular region of the cortex, spaced a minimal distance of 110 mum apart, at a maximum density of about 8000/cm-2. In the perifoveal cortex, Meynert cells are spaced about 400 mum apart and packed at a density of approximately 625/cm-2. Each Meynert cell has an apical dendrite and many large basal dendrites. The perikaryon and primary segments of all dendrites are spine-free; however, more distally a total of 36 000 spines are present, differentially disposed upon the dendritic surfaces. The basal dendrites bear over 77% of the spines on the Meynert cell, although they account for only 66% of the total length of the dendritic arborization. The first part of the apical dendrite is the most densely decorated with appendages, accounting for almost 10% of the spines on the whole dendritic tree. The apical dendrite becomes progressively less spiny as it passes through the superficial part of layers IV and III; less than 2.5% of the total number of spines of the Meynert cell project from this part of the apical dendrite. When the dendrite reaches layer II it bursts into an umbel of rapidly tapering branches. These are highly spinose, accounting for 8-13% of the cell's total, dispersed over only 23% of the linear dendritic length. It is suggested that this differential distribution of thorns can be correlated with the axonal inputs in the various cortical layers, and that the Meynert cell is designed to receive maximal information from layers I and II, and from layers V and VI, which are sources mainly of intracortical inputs. Thus the Meynert cell may be principally concerned with integrative information. In the perifoveal cortex, the basal dendrites of adjacent Meynert cells overlap considerably, and the apical terminal bouquet dendrites do not. In the macular cortex, because of the increased frequency of these neurons, both basaal and apical terminal dendritic fields overlap. A model is developed to illustrate these hypotheses.


Histologic and histometric study of the effect of fluoride on the rat mandibular condyle. The effect of fluoride on the rat mandibular condyle was studied histologically and histometrically. The condyles of the rats that received 50 ppm fluoride in the drinking water for 17 weeks did not differ in structure from those of the control rats fed tap water containing 1 ppm fluoride. However, the condyles of the rats given 100 ppm fluoride in the drinking water for the same period showed a significant increase in both the thickness of the cartilage layer (P smaller than 0.02) and the density of cancellous bone (P smaller than 0.01) when compared to the controls. The thickening of the cartilage layer was due to an increase in the number of hypertrophied chondrocytes. The trabeculae of cancellous bone were thicker and consequently the bone marrow spaces were extremely reduced. The trabeculae contained more calcified cartilage in their cores.


Proceedings: Preliminary characterizaiton of the histamine releasing activity of cotton dust.


Identification of fluorescent antibodies in periodontitis.


The role of adaptive regulation in the pathophysiology of psychiatric disease.


On the origin of RNA tumor viruses.

On the origin of RNA tumor viruses.


The staining of elastic tissue and related fibres in uterine blood vessels.


A technique for thin methacrylate sections of bone marrow.


Work simplification applied to Thyopac-3 and Thyopac-4 kits.


Biological effects of 5-azacytidine in eukaryotes. 5-Azacytidine (NSC-102 816) was prepared synthetically and independently isolated from the culture filtrate of Streptoverticillium ladakanus. It is an s-triazine analogue of cytidine possessing a broad spectrum of biological effects. In mammalian tissueit is phosphorylated to 5-azacytidine 5-phosphates and incorporated into different species of RNAs and into DNA. 5-Azacytidine 5-monophosphate inhibits  orotidine 5-phosphate decarboxylase blocking thus the de novo pyrimidine synthesis. Following the administration of 5-azacytidine a rapid breakdown of liver polyribosomes has been observed; furthermore, in different systems a profound inhibitory effect of the drug on the maturation of ribosomal RNA has been found. 5-Azacytidine interferes with different induced liver enzymes; in some cases their activity is elevated since the rate of enzyme degradation is decreased. The cytostatic effect of the drug is directed primarily against lymphatic leukemia although some recent reports indicate its  action also against human solid tumours. Chemotherapy of leukemic mice by 5-azacytidine results simultaneously in the depressed synthesis of liver and spleen polyamines. 5-Azacytidine exhibits furthermutagenic, abortive, immunosuppressive, antimitotic, radioprotective and virostatic effects. The drug also affects DNA and protein synthesis in embryonic tissues, cells intissue culture, regenerating livers, in bacteria and phages. The changes associated with the emergence of resistance towards 5-azacytidine are associated with the decreased activity of uridine kinase in mouse leukemia cells. On the contrary, in adult rate livers5-azacytidine administration leads to the increased activity of this enzyme. Differentauthors have used 5-azacytidine as a tool for the study of biochemical mechanisms connected with a cell proliferation and division.


Migration-inhibitory effect of serum from patients with prostatic cancer. Serum from patients with carcinoma of the prostate were observed to possess a factor(s) capable of inhibiting the migration of allogeneic leukocytes in the direct leukocyte migration test. Maximum inhibitory activity was obtained with those sera possessing an elevated level of an as yet unidentified factor(s) in the alpha2-globulin fraction of the serum of these patients. The presence of such a factor(s) may prevent interaction between leukocyte-inhibiting factor sensitive cells and tumour cells and emphasizes the role ofhumoral inhibitory or 'immunoregulatory' factors, such as alpha2-globulin, on immunologicresponses as blastogenesis and inhibition of leukocyte migration, as potential abrogators of mechanisms of host-resistance, e.g., immunologic surveillance.


Persistence and movement of BHC in a watershed, Mount Mitchell State Park, North Carolina--1967-72.


Contribution of household dust to the human exposure to pesticides.


Cytogenetical diagnosis of malignant pleural effusions.


Propranolol (Inderal) therapy in pre-operative care for diffuse toxic goiter. Preliminary report.


Fibre systems in sputum.

Fibre systems in sputum.


Accelerated clearing and staining of teratologic specimens by heart and light.


A clinicopathologic study of a peculiar foveomacular dystrophy.


Prostatic disease in the dog.

Prostatic disease in the dog.


Further observations on atypical band keratopathy in glaucoma patients.


Histological components of tibial fracture callus in growing osteopenic rats.


Factors affecting prognosis of endometrial carcinoma.


Absence of effect of endotoxin on the isolated ileum of the guinea-pig.


A theory on the action of bacterial endotoxins.


The liver-pathogenic role of spleen suspension of rats treated with carbon tetrachloride.


Studies on alpha2-macroglobulins.

Studies on alpha2-macroglobulins.


Studies on connections between quality of plasma and impurities of gamma globulin and albumin preparations.


Freeze-dried virus antigens and FITC-conjugated immune sera for virus diagnostic purposes.


Present state and perspectives of the farctionation of human plasma, serum and placenta.


A study of immunospecifically isolated tetanus antibodies.


Interaction between lysozyme and some lactoferrin complex in human milk.


Reoxidation of reduced hen egg-white lysozyme. (II). Circular dichroism and fluorescence emission analysis.


Modification of tyrosine residues in human alpha-lactalbumin: effect upon the lactose-synthase specifier activity.


Chlorpromazine and phospholipid metabolism in the rat hypothalamus. Effect of pretreatment with piracetam.


Chromatographic equilibrium of human alpha-lactalbumin.


Uptake and intracellular localization of kanamycin and gentamycin in the lysosomes of cultured fibroblasts.


Mutation sites in the coat-protein gene of bacteriophage MS2.


Fluorimetric and nuclear magnetic resonance binding studies of a fluorescent dye interacting with alpha-lactalbumin and lysozyme.


The synthesis of human placental lactogen by human placental ribosomes.


Salinity-induced changes in the alanine and aspartic aminotransferase activity in three marine bivalve molluscs.


Eye movements elicited by electrical stimulation of the pontine reticular substance.


Inhibition of ciliary movements by Ni-2+ions in triton-extracted models of Paramecium caudatum.


Protein nutrition of Tenebrio molitor L. XVIII. Growth of larvae of race F fed protein blends of cereals and legumes.


The effect of chelation of calcium ions in cerebrospinal fluid on the osmotic thirst in dogs.


The cardiac pressoreceptors and the heart enlargement.


Catecholamines in blood during direct stimulation of the hypothalamus in dogs.


The estimation of contractile element velocity during the isovolumic period: alterations by cardiac output and contractile state.


Distribution of some phosphohydrolases in glomerular and tubular fractions isolated from rabbit kidney.


The regeneration with cysteine of gastropod haemocyanin mediated by hydrogen peroxide.


Effects of osmolality on hypoxic myocardium.


Results obtained with two different perfusion chambers for double sucrose gap on voltage clamp currents in frog atrial trabeculae.


Decision component parameters.

Decision component parameters.


The rate of contraction of some striated muscles in Perodicticus potto.


Effect of the ionic composition of the extracellular fluid on energy metabolism of the liver in hypothermic anoxia.


The precursors of milk proteins.

The precursors of milk proteins.


Messenger RNA levels from the bipolar arginine ECBH operon of Escherichia coli.


Characterization of free reverse transcriptase in the blood plasma of leukemic chicken.


Physico-chemical characterization of ribosomes isolated from dormant embryos and nauplii of Artemia salina.


Mutant selection in the control region of the arg ECBH bipolar operon of Escherichia coli.


Virginiamycin, an inhibitor of protein synthesis: binding of the factor S to the 50 S ribosomal subunit.


Alpha-mannosidase in the hen's egg yolk.


Cholinesterase activities in the hen's egg.


Toxicity of quartz and kaolin towards membranes: effect of lysozyme.


Synthesis of a poly(A)-segment, covalently linked to the 3'-end of bacteriophage MS2 RNA.


Influence of alloxan-diabetes and insulin on liver protein kinase.


Partial conservation and transfer to progeny of bacillus subtilis bacteriophage 2C DNA.


On the substrate specificity of phosphorylase a phosphatase.


Requirement of iron in the induction process of the cyanide-insensitive respiration in Endomycopsis lipolytica.


Activation of liver glycogen phosphorylase by vasopressin.


Synthesis in vitro of Artemia salina proteins in an homologous cell-free system.


Cyclic nucleotides and growth regulation in fibroblasts.


Reoxidation of reduced hen egg-white lysozyme. (I). Chromatographic and enzymic properties of the reoxidation products.


The female child as a surrogate object.

The female child as a surrogate object.


Youth and pornography in social context.


Immunological evidence to show that the N-acetylglucosaminidase and N-acetylgalactosaminidase activities of Dictyostelium discoideum reside in the same protein molecule. Antibodies were produced against purified beta-N-acetylhexosaminidase from Dictyostelium discoideum. Ouchterlony tests produced a single precipitin band with both beta-N-acetylglucosaminidase and beta-N-acetylgalactosaminidase activities. Both activities were co-precipitated in exactly the same proportions in quantitative immunoprecipitation reactions. We conclude that one enzyme protein catalyses the hydrolysis of both N-acetylglucosaminides and N-acetylgalactosaminides.


Completion of the analysis of the primary structure of the variable domain of a homogeneous rabbit antibody to type III pneumococcal polysaccharide. The amino acid sequence between residues 70 and 116 of the V (variable) region of the H (heavy) chain derived from rabbit antibody BS-5, specific for type III pneumococcal polysaccharide, was determined. The sequence of this section of the H chain which includes the hypervariable residues 94 to about 112 was unique, although minor variant sequences present in the H chain preparation would not have been detected by the techniques used in this work. Taken together with the known sequences of the N-terminal 69 residues of H chain BS-5 (Jaton & Braun, 1972) and of the V region of the light chain (Jaton, 1974b), the data establish the complete sequence of the V domain of a rabbit immunoglobulin G. The V region of H chain BS-5 is compared with the basic sequences of the three human V region subgroups known to date, with one mouse H chain, and with guinea-pig pooled H chains. Even though chains from guinea pig and mouse clearly belong to the subgroup III of variability (V(HIII)), rabbit H chain BS-5 (allotypic variant a(1)) appears more closely related to the subgroup V(HII) than to the subgroups V(HIII) or V(HI). The homology between V(L) and V(H) regions of antibody BS-5 (28%) is not greater than that observed between the V(H) region of antibody BS-5 and the V(L) regions of different rabbit antibodies.


The importance of seminal plasma for human sperm motility.


Sensitivity to mycobacterial antigens.

Sensitivity to mycobacterial antigens. In a study carried out in 1971, each of 3 030 persons was tested simultaneously with tuberculin RT 23 and two other PPD sensitins-PPD-S and PPD-A, PPD-B and PPD-Y, or PPD-G and PPD-F. Of the 2 558 persons whose reactions were read, 20.2% had previously been vaccinated with BCG and 79.8% were unvaccinated. RT 23 and PPD-S produced almost identical mean indurations. Both elicited much higher reactions than the sensitins prepared from atypical mycobacteria. Correlation of the sizes of induration obtained with RT 23 and with the other sensitins showed that low-grade sensitivity was due to cross-reactions to human tuberculous infection and that in no case did an "atypical" sensitin produce an induration of wider diameter than RT 23 did. It is concluded that nonspecific tuberculin sensitivity was not demonstrated in this study.


Redistribution of immunoglobulin determinants on human lymphocytes in lymphoproliferative disorders.


The epididymis as a possible site for control of fertility in the male.


Studies on alpha-2-macroblobulins.

Studies on alpha-2-macroblobulins.


Impurities in gammaglobulin and albumin preparations: influence of the source material.


Purification of antitetanus human IgG by immunoadsorption.


Immunological studies on the presence of placental material in retroplacental blood.


Hepatitis B: Au/HA-antigen during production of human albumin and gammaglobulin.


Transmission of viral hepatitis, type B, by plasma derivatives.


Standardization of human antivaccinia immunoglobulins and elaboration of a national substandard preparation.


Preparation of anti-Rho (D) specific immunoglobulins according to WHO recommendation.


Content of IgG, IgA and IgM immunoglobulins in international units in normal and IgA-enriched gammaglobulins.


Isolation, purification and biological properties of horse precipitating and non precipitating antibodies.


An antibody sandwich method for the radioimmunoassay of human alpha-fetoprotein.


Immunoenzymology of L-asparaginase from the BCG strain of Mycobacterium bovis.


The behaviour of antigenically related influenza viruses of differing virulence on disulphide-linked immunosorbents.


Opsonic properties of human serum alpha-2 hs glycoprotein.


The thymic suppre-sor cell. II. Metabolic requirements of suppressor activity.


Membrane antigenic changes associated with PHA transformation of mouse spleen cells in vitro.


Distribution of concanavalin a receptors on normal rat liver cells and zajdela ascites hepatoma cells. The distribution of Concanavalin A receptors in cultures of normal rat liver cells and of Zajdela ascites hepatoma cells of the rat was investigated by the Con A-po technique (Bernhard and Avrameas, 1971). Con A-po labelling of the cell surface showed a patchy distribution of Concanavalin A receptors in ascites hepatoma cells, whereas continuous Con A-po labelling was seen at the surface of normal rat liver cells. The different distribution of Concanavalin A receptors was caused by rapid internalization of Con A-po labelled material and not by a simple rearrangement of the receptors. The significance of this process is discussed with respect to Concanavalin A receptor mobility and membrane stability after cell transformation.


Isolation of a primate type-C virus from a lymphomatous baboon. A type-C RNA virus has been isolated from various tissues of a lymphomatous baboon (sp. P hamadryas). Virus isolations were made by co-cultivating baboon cells from the inguinal and mesenteric lymph nodes, testes, kidneys and spleen with cells of canine or human origin. The isolated virus grew in canine, bat, rhesus, and human cells but not in cells of mouse, rat, cat or rabbit origin. The baboon isolate resemble a type-C virus when infected cells were examined by thin section in the electron microscope. In addition, the virus was capable of providing helper function by rescuing and transmitting the Moloney and Kirsten sarcoma virus genome from non-productively transformed cells. Antibody directed against the RD114 virus reverse transcriptase was very effective in inhibiting the baboon virus polymerase while while anti-mouse and woolly type-C virus polymerase antibodies had no significant inhibitory activity. Further analysis by immunodiffusion and competitive radioimmune assay revealed a close immunological relationship between this virus, RD114 and another type-C virus isolated from the placenta of a different species of baboon. Finally, three different classes of interspecies antigenic determinants have been demonstrated in mammalian type-C virus isolated from the placenta of a different species of baboon. Finally, three different classes of interspecies antigenic determinants have been demonstrated in mammalian type-C viruses.


Actinomycin-D-resistant in vitro mouse cell line derived from a methylcholanthrene-induced sarcoma: decrease of malignancy and antigenic characteristics. The tumorigenic EPO clonal cell line, derived from a methylcholanthrene-induced murine sarcoma, was exposed to increasing concentrations of actinomycin D and gave rise to a subline, resistant to 0.02 mug of actinomycin D per ml of medium, which was designated EPO/ADj. Drug resistance was accompained by a striking decrease of tumorigenic capacity as determined by the tumor take incidence and tumor growth rate in syngeneic C57BL/6 mice (normal and X-irradiated), as well as by tumor take incidence in the cheek pouch of cortisone-treated weanling Syrian hamsters. One of the tumors obtained after inoculation of EPO/ADj cells into syngeneic mice was reexplanted in culture and developed as the EPO/ADj/T subline. It was found to be relatively resistant to actinomycin D as compared to the parental EPO cells. The morphology of cells changed with actinomycin-D-resistance: EPO/ADj cells were more spread and flattened and less overlapping than the original fibroblast-like EPO cells. EPO/ADj/T cells, however, had an aspect similar to that of EPO cells. No major differences were seen between the karyotypes of EPO, EPO/ADj and EPO/ADj/T cells. Tumor-specific antigen(s), characteristic of drug-sensitive, parental EPO line, was expressed in the resistant EPO/ADj and EPO/ADj/T lines, as shown by: (a) transplantation resistance to challenge with EPO cells in syngeneic mice pretreated with EPO/ADj cells; and (b) cross-reactivity in indirect immunofluorescence tests performed with sera from syngeneic animals hyperimmunized with EPO or EPO/ADj cells. Furthermore, an additional surface antigen(s), absent from EPO cells, was demonstrated in EPO/ADj and EPO/ADj/T cells by means of immunofluorescence tests performed with specific anti-EPO/ADj syngeneic sera previously absorbed on EPO or EPO/ADj cells.


The detailed chromosome constituiton of a benzpyrene-induced sarcoma. A tentative model for G-band analysis in solid tumors.


The vanding pattern in philadelphia-chromosome negative chronic myeloid leukemia.


Activity of uridine kinase in different lines of AKR leukemic mice and its relation to chemotherapy with 5-azacytidine. The sensitivity of different wild-type and 5-azacytidine-resistant lines of AKR leukemic mice to 5-azacytidine varies in relation to the activity of uridine kinase isolated from corresponding leukemic livers. The enhancement of liver uridine kinase activity observed in leukemic mice following the administration of a single dose of 5-azacytidine is accounted for by the presence of hepatocytes in infiltrated leukemic livers. The optimal schedule for the treatment of AKR leukemic mice with 5-azacytidine requires equally divided doses administered daily and not an initial high dose followed by low doses.


Cytogentical studies with G-band technique of established cell lines of human malignant glomas.


An experimental demonstration of discriminated (nongeneralized) imitation.


Clinical trial of bleomycin on female genital cancer: a preliminary report.


The combined therapy of carcinoma of the tongue by using bleomycin and radiation.


Retention mucoceles of the oral mucosa.

Retention mucoceles of the oral mucosa.


Some physicochemical and pharmacological properties of morphine-2,3-quinone, the morphine metabolite in the rat brain.


Studies on lividomycin. I. In vitro antibacterial activities of LVDM against clinical isolates of Mycobacterium tuberculosis.


New weapon in war on lice; Stafford-Miller launch Quellada in Australia.


Two new types of C-band variants in human chromosome (6ph+ and 12ph+).


Estrogen receptor: a valid test for selection of breast cancer patients for endocrine ablation.


Bleomycin 111-I scanning: a new technique for detecting subclinical metastatic cancer.


Anemia from sleep deprivation with anticoagulants in rats with enhancement by PCPA.


Efferent projections of the subthalamic nucleus.


Gel isoelectric focusing of cerebrospinal fluid proteins: a potential diagnostic tool.


Gastric antisecretory and antiulcer agents.


Studies of the mechanism of histamine release from lung tissue in vitro by cotton dust extracts.


Effect of a histamine H-2-receptor antagonist on immunologically induced mediator release in vitro.


Histamine release from mast cells by compound 48/80. The membrane action of zinc.


Problems in the assay of histamine release by gelatin: o-Phthaldialdehyde-induced fluorescence, inhibition of histamine methyltransferase and H-1-receptor antagonism by Haemaccel.


Evaluation of histamine elimination curves in plasma and whole blood of several circulatory regions: a method for studying kinetics of histamine release in the whole animal.


The smooth endoplasmic reticulum and the retrograde and fast orthograde transport of horseradish peroxidase in the nigro-striato-nigral loop.


The mast cell and disodium cromoglycate in immediate type reactions.


Enzyme activation and the mechanism of neutrophil chemotaxis.


Chemotaxis of eosinophil leukocytes in relation to immediate-type hypersensitivity and the complement system.


Plasma GH levels after L-Dopa in prepuberal normal children and in pituitary dwarfs.


Pituitary secretory reserve in patients with amenorrhea associated with galactorrhea.


Golgi impregnation study on the liquor-contacting cells bordering the preoptic recess in amphibians.


Demonstration of repair of potentially lethal damage in plateau phase cells of Ehrlich ascites tumor after exposure to bleomycin.


Investigation of the ovarian chromaffin tissue in the fresh water teleost fishes.


Leukocyte osmotic fragility in patients with hematologic neoplasms and cancer.


Studies on passive immunity in the foal. III. The characterization and significance of neonatal proteinuria.


Haematological and plasma protein changes in sheep experimentally infected with Corynebacterium pseudotuberculosis.


Economic impact of mass production of alternative low emission automotive power systems.


Afferent influences upon human genioglossal muscle.


Biochemical findings in multiple sclerosis I. A detailed study of the plasma lipid fractions of 484 multiple sclerosis patients compared with 152 other neurological diseases.


Double ring formation in single radial immunodiffusion for kappa chains in multiple sclerosis cerebrospinal fluid.


A new polygenic disturbance: cystinuria, leucinuria and spinal muscular atrophy.


Changes of gamma globulins in serum and cerebrospinal fluid of patients with subacute sclerosing panencephalitis.


Oxytalan connective tissue fibers: a review. Oxytalan connective tissue fibers are a separate and distinct fiber type. Although current histochemical methods cannot distinguish pre-elastic from oxytalan fibers, the two fiber types are readily distinguished by electron microscopy. Oxytalan fibers are found in periodontal membranes of all teeth of man, monkeys, rats, guinea pigs and mice. Increased numbers and size of oxytalan fibers are observed in periodontal membranes of teeth subjected to increased stress, such as those used for bridge abutments. Edwards (1968) observed increased size and number of oxytalan fibers in periodontal membranes of dog incisors subjected to orthodontic forces. Some oxytalan fibers serve to support the blood and lymphatic vessels leading to the teeth. Oxytalan fibers appear to have a protein component and a stainable component digestible with beta-glucuronidase after peracetic acid digestion. Oxytalan fibers develop in repair tissues of the periodontal membrane. Although oxytalan fibers probably develop in relation to tumors developed from dental tissues, electron microscopy must be employed to distinguish oxytalan from developing elastic tissues inasmuch as histochemical methods are inadequate.


Editorial: the medical recording service foundation.


A general synthesis of N-glycosides. V. Synthesis of 5-azacytidines.


Expanded roles for nurses--the view of a physician.


Epithelial cell structure and function following massive intestines resection.


Useful buffer and gel systems for polyacrylamide gel electrophoresis.


Effect of prednisolone on callus formation.


The effects of juvenile hormone on the prothoracic glands in Galleria mellonella L. I. Morphology of the glands in the course of the postembryonic development.


Irradiation of brain metastases.

Irradiation of brain metastases. A series of 124 patients with intracranial metastases, treated by irradiation, has been reviewed, retrospectively and prospectively, and the results are reported. Worthwhile palliation was obtained in 79 (63%) of the total number of patients with functional improvement documented in 52 (41%). The uncorrected mean survival was 4.7 months. The addition of surgery to irradiation did not improve results significantly in this series. Therefore, surgical removal should be performed on special indications such as rapidly progressing increase in intracranial pressure unresponsive to steroids or shunt, or if the etiology of the intracranial lesion is uncertain.


A polarization microscopic study of granular pneumocytes and alveolar interface in rat lung.


The C-cells of the rat thyroid in different stages of postnatal ontogenesis.


Granular abate for control of mosquitoes larvae.


Turnover of myelin and other structural proteins in the developing rat brain. 1. Protein metabolism of myelin and other subcellular components from developing rat brain was studied for periods from 5h to 210 days after intraperitoneal injection of [(3)H]lysine and [(14)C]glucose. 2. Half-lives for total brain proteins (t(0.5)) were 27 days after [(3)H]lysine and 4 days after [(14)C]glucose injection. 3. Factors accounting for the difference in the turnover rates obtained with different precursors, and the problem of reutilization of the label were investigated. 4. The catabolism of purified myelin proteins was studied and the half-lives of individual myelin proteins were calculated. 5. Myelin basic proteins turned over at two different rates. Half-life of the fast component of myelin basic proteins was 19-22 days and the slow component exhibited a high degree of metabolic stability. 6. Proteolipid protein underwent slow turnover. High-molecular-weight Wolfgram (1966) proteins underwent (relatively) fast metabolism (t(0.5) of 17-22 days).


The isolation and identification of the P-component of normal human plasma proteins. A normal human plasma protein called the P-component, which has a reaction of identity with the pentagonal structure found in amyloid-laden organs, has been isolated and identified with a recently characterized protein, the 9.5S alpha(1)-glycoprotein.


The correlations of positive skin tests with inhalants in asthma of probable allergic origin.


Intervention programmes for preschool children with delayed language development: a preliminary report.


Immunoglobulin-bearing lymphocytes in monoclonal gammapathies.


G-banding of 3 multiple myeloma marker chromosomes.


Factors affecting the efficacy of live poliovirus vaccine in warm climates. Efficacy of type 1 Sabin vaccine administered together with antihuman gamma-globulin horse serum to breast-fed and artificially fed infants in Uganda. A virologically controlled field trial was conducted with live monovalent type 1 poliovirus vaccine in children aged 3-30 months living in a rural area of Uganda, in an attempt to find out the reason for the poor efficacy of such vaccine often observed in countries with a warm climate. Groups of breast-fed and of artificially fed infants received the vaccine orally, either alone or mixed with horse serum prepared against partly purified human gamma-globulin. Irrespective of the diet, the "take rate"-measured by the rates of vaccine virus excretion and of antibody conversion-was found to be poor when the vaccine was given alone but satisfactory when it was given together with the horse antiserum. However, the extent and duration of vaccine virus multiplication in the intestinal tract proved to be limited and the mean antibody level elicited by the vaccination, irrespective of the schedule of vaccine administration, was low. These results, besides indicating that breast-feeding does not influence the efficacy of vaccination in the age groups studied, revealed the presence of an inhibitor in the alimentary tract. This inhibitor acts against the multiplication of vaccine virus, which may be blocked by antibodies in the horse antiserum for a limited period at the time of vaccination. Interference between the enteroviruses and the vaccine strain was also found to be responsible for decreasing the efficacy of vaccination, though its role was secondary to that of the inhibitor. Revaccination experiments showed that the effects of both inhibitor and interference may be overcome by repeated administration of the vaccine.


A possible case of partial trisomy for chromosome 22: further evidence from Giemsa banding studies.


Association of serum and red cell phenotypes and Australian antigen in Down's syndrome.


Recording pulsations in echo-encephalography.


Computer-terminal operating and communication aid for the severely handicapped.


Television in the Faculty of Medicine at Glasgow University. A two-year report.


A new approach to teaching histology at the University of Louvain.


A positive method of focusing x-ray lantern slides.


Reserpine and breast cancer.

Reserpine and breast cancer.


Retrospective study of the association between use of rauwolfia derivatives and breast cancer in English women.


Angina pectoris with normal coronary arteries. Transvenous myocardial biopsy in diagnosis.


Reserpine use in relation to breast cancer.


A new approach to viral chemotherapy. Inhibitors of glycoprotein synthesis.


Significance of complement-positive Coombs test in patients with glomerular disease.


T or B cell origin of some non-Hodgkin's lymphomas.


Cell-mediated immunity and phagocytosis and killing function in children with severe iron-deficiency anaemia.


Changing patterns in epidemiology of Crohn's disease.


Ascorbic-acid saturation and ethanol metabolism.


Poor kidney-transplant survival in recipients with frozen-blood transfusions or no transfusions.


Localisation of deep-venous thrombosis using technetium-99m-labelled urokinase.


Editorial: Rauwolfia derivatives and cancer.


Automatic measurement of chest drainage by an ultrasonic system.


Editorial: Myocardial ischaemia without coronary arterial disease.


Editorial: Monoamine oxidase and migraine-a causal link?


Editorial: Jack becomes master?

Editorial: Jack becomes master?


Editorial: Injury before birth.

Editorial: Injury before birth.


Editorial: Prescribers' choice.

Editorial: Prescribers' choice.


Editorial: Biological effects of asbestos.


Editorial: Facts and myths about sickness absence.


The benzodiazepine bonanza.

The benzodiazepine bonanza.


Progeny of childhood-cancer survivors.

Progeny of childhood-cancer survivors.


Letter: Evolution of kwashiorkor and marasmus.


Editorial: Protein requirement.

Editorial: Protein requirement.


Letter: Follow-up of patient with portacaval shunt for the treatment of hyperlipidaemia.


Letter: Legal status of the unborn.

Letter: Legal status of the unborn.


Letter: Rapid chromosome diagnosis.

Letter: Rapid chromosome diagnosis.


Letter: Reye's syndrome.

Letter: Reye's syndrome.


Letter: Unsaturated fatty acids and renal transplantation.


Letter: Prolactin and migraine.

Letter: Prolactin and migraine.


Letter: IgE-containing plasma cells in acute tubulo-interstitial nephropathy.


Letter: Microbial-antigen detection and complex antisera.


Letter: Classification and nomenclature of malformations.


Letter: Microbial-antigen detection.

Letter: Microbial-antigen detection.


Low mitotic activity of granulopoietic precursor cells in Ph1-chromosome-negative chronic myeloid leukaemia.


Letter: Secular trends in leukaemia mortality.


Letter: Tinidazole in treatment of giardiasis.


Letter: Oxolinic acid in urinary infections.


Letter: Propranolol and pregnancy.

Letter: Propranolol and pregnancy.


Letter: Thyrotropin-releasing hormone and depression.


Letter: Thrombocytopenia during treatment with ampicillin.


Letter: Acute non-allergic reaction to aqueous procaine penicillin.


Letter: Are Pompidou's refringent lymphocytes thymus-dependent?


Letter: Inhibition of lymphocyte response to stimulants by unsaturated fatty acids and prostaglandins.


Letter: Scientific medicine.

Letter: Scientific medicine.


Letter: "Rotavirus" in gastroenteritis.

Letter: "Rotavirus" in gastroenteritis.


Letter: HL-A antigens and M.I.C. responsiveness in systemic lupus erythematosus.


Letter: HL-A antigens and coeliac disease.


Letter: Neostigmine after bowel surgery.


Letter: Non-specific enhancement of glomerular filtration by corticosteroids.


Letter: Tumour-cell mucous protein and C.E.A.


Comparative trial of L-tryptophan and E.C.T. in severe depressive illness.


Acquired valvular heart-disease in patients who keep pet birds.


Effect of renal transplantation of uraemic neuropathy.


Some effects of changing to low-tar and low-nicotine cigarettes.


Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus.


Transplacental transmission of hepatitis-B virus by symptom-free chronic carrier mothers.


Minocycline: Possible vestibular side-effects.


Pitfalls in the study of hepatitis A.

Pitfalls in the study of hepatitis A.


Clinical significance of T-cells in chronic lymphocytic leukaemia.


Spinal-fluid lysozyme in the diagnosis of central-nervous-system tumours.


Expression of human T and B lymphocyte cell-surface markers on leukaemic cells.


Hand-held dynamometer for evaluating voluntary-muscle function.


A spring-heeled rocker-soled plaster boot.


Editorial: Exploiting interferons.

Editorial: Exploiting interferons.


Editorial: Treatment of sickle-cell crises.


Editorial: Sandbags from Mrs Castle.

Editorial: Sandbags from Mrs Castle.


Editorial: Floral strategy.

Editorial: Floral strategy.


Editorial: The menace of cholera.

Editorial: The menace of cholera.


Editorial: Research at large.

Editorial: Research at large.


Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention.


What dose the general practitioner want to know about the cancer patient?


Letter: Whooping-cough vaccination.

Letter: Whooping-cough vaccination.


Letter: Rauwolfia derivatives and cancer.


Human placental lactogen and fetal abnormality.


Letter: Clinical trials with vitamin C.

Letter: Clinical trials with vitamin C.


Letter: Ascorbic acid and long-term steroids.


Letter: Omental transposition for drainage of cerebrospinal fluid.


Letter: Atrophic gastritis and dermatitis herpetiformis.


Letter: Home treatment for patients with haemophilia.


Letter: Natural history of atrophic gastritis.


Letter: Judging clinical competence and videotape techniques.


Letter: Lymphocyte hazards to the fetus.


Letter: Circadian rhythm in murine tolerance of daunorubicin.


Letter: Treatment of congenital dislocation of the hip.


Letter: Mobile coronary care.

Letter: Mobile coronary care.


Letter: Behavior of tumours in conditions of experimental magnesium deficiency.


Letter: Allergy, tolerance, and immunoglobulin A.


Letter: Dangers of corticotrophin in phaeochromocytoma.


Letter: Infection in the sink.

Letter: Infection in the sink.


Letter: Papovavirions in urothelium of treated lymphoma patient.


Letter: Mortality among vinyl-chloride workers.


Letter: Subcutaneous heparin.

Letter: Subcutaneous heparin.


Letter: Angiokeratoma corporis diffusum and lysosomal enzyme deficiency.


Letter: Ultrasonic cephalometry.

Letter: Ultrasonic cephalometry.


Letter: B.C.G. in rheumatoid arthritis.

Letter: B.C.G. in rheumatoid arthritis.


Letter: Carbon monoxide, smoking, and constitution.


Letter: Does hiatus hernia affect competence of the gastrooesophageal sphincter?


Letter: Intestinal potential difference during glucose absorption.


Letter: Speaking aid.

Letter: Speaking aid.


Letter: Haemolytic-uraemic syndrome: evidence for intravascular C3 activation.


Letter: Ageing, immune response, and mortality.


Letter: Termination by prostaglandin pellets in very early pregnancy.


Fergus Robert Ferguson.

Fergus Robert Ferguson.


Relative effectiveness of various solvents for oil red O.


Histochemical identification of primordial germ cells in human embryos by PAS reaction.


Reaction spectrum of human HBs antibodies.


Sinusitis -- 1974.

Sinusitis -- 1974.


Photocoagulation of exudative senile maculopathy. A followup report.


Laboratory techniques in rabies: histopathological diagnosis.


Activation of peripheral lymphocytes in the course of experimental allergic encephalomyelitis in the guinea-pig.


Identification of climbing fibres in the cerebellar cortex of the rat by means of 3H-leucine EM-autoradiography.


Retrograde intracellular staining and identification gastropoda neurones with CoCl2.


Effects on staining of the presence of various kinds of dye impurities.


Etomidate, a new intravenous hypnotic.

Etomidate, a new intravenous hypnotic.


Laboratory investigations on neuroparalytic accidents associated to suckling mouse brain rabies vaccine.  II.--Encephalitogenicity of murine brain myelin preparations.


A study of the distribution of the major subtypes of hepatitis B antigen in Melbourne.


Combined chemotherapy, radiotherapy, and surgery in the treatment of advanced but localized solid malignant tumours.


Studies on antigenic competition. V. Evidence for the involvement of a thymic-derived cortisone-sensitive cell in the mediation of antigenic competition.


Thymus cell traffic induced by antigen stimulation.


Induction of anti-hapten antibody response by hapten-isologous carrier conjugate. I. Development of hapten-reactive helper cells by hapten-isologous carrier.


The influence of epitope density on the immunological properties of hapten-protein conjugates. I. Characteristics of the immune response to hapten-coupled albumen with varying epitope density.


Immune responses to myelin basic protein in mycobacterial-induced suppression of experimental allergic encephalomyelitis.


Antigen cross-reactivity in the macrophage electrophoretic mobility test. A study using cellular affinity chromatography.


Phagocyte function in protein-calorie malnutrition.


Chronic infections in a family with hereditary deficiency of IgG2 and IgG4.


Studies into the occurrence of soluble antigen-antibody complexes in disease. VI. Further characterization of the biological and physical properties of the rheumatoid biologically active factor (RBAF).


Splitting of human thyroglobulin. III. Comparison of fragments obtained during enzymatic digestion and by reduction and alkylation.


Cells binding the antigen keyhole limpet haemocyanin in the peripheral blood and in the lymphocyte cultures of non-immune and immunized human subjects.


Immunoelectrophoretic analysis and radial immunodiffusion assay using plasminogen purified from fresh human plasma.


Cilia membrane abnormalities induced by streptomycin and other aminoglycoside antibiotics in Stentor coeruleus.


Hageman factor-independent fibrinolytic pathway.


Perceptual-motor programs.

Perceptual-motor programs.


The pituitary gland of a teleost, Nandus nandus (Ham.).


Studies on the renal organ of the percoid teleost fish, Nandus. I. Morphohistological and histochemical considerations.


Intracisternal inclusion bodies induced in animals: their transformation and significance.


A teaching-aid programmer.

A teaching-aid programmer.


Sectioning and staining of leucocyte migration cultures for light microscopy.


Some central nervous system actions of 5-(3 dimethylamino-2-methyl-propyl) dibenzo [a, d] [1,4] cyclooctadiene hydrochloride.


Attitudes on population.

Attitudes on population.


The influence of antigen-antibody-complexes on the cellular antibody-formation.


[Supravital staining of the peripheral blood and cultivated lymphocytes with toluidine blue].


Appearance of the encephalitogenic activity in the non-encephalitogenic fraction from human brain during a prolonged storage.