Fibromuscular dysplasia of the renal artery with medial dissection. A case simulating polyarteritis nodosa.


Fire-walking: a scientific investigation.


Human infections with Dirofilaria, a filarial parasite of animals in Ceylon, with a brief review of recent cases.


Hormonal regulation of protein degradation in hepatoma cells in tissue culture.


Pathway from progesterone to 5 alpha-reduced C19 steroids not involving androstenedione and testosterone in immature rat testes in vitro.


Adult endocardial fibroelastosis following electric shock.


Repeat cesarean section in a low socio-economic population.


Thymoma, erythroid hypoplasia and myasthenia gravis. Report of a case with ultrastructural study.


Meckel's diverticulum.

Meckel's diverticulum.


Acute yellow phosphorus rat poisoning.

Acute yellow phosphorus rat poisoning.


The new Supplemental Security Income Program.


Electrocardiographic diagnosis of idiopathic pericarditis.


The view box: aberrant papilla.

The view box: aberrant papilla.


It's up to you.

It's up to you.


Editorial: New antagonists excite an old histamine prospector.


Bordetella pertussis as a beta-adrenergic blocking agent.


Characteristics and caries experience of tetracycline-affected dentitions.


Quantitative studies on anaphylaxis in guinea-pigs passively sensitized with homologous antibody.


Immuno-regulatory role of spleen localizing thymocytes.


Alpha-alpha'-dipyridyl or ortho-phenanthroline stimulation of the soluble reduced nicotinamide adenine dinucleotide oxidase from Bacillus subtilis spores and dipicolinic acid inhibition of the stimulated enzymes. Soluble reduced nicotinamide adenine dinucleotide oxidase activity in extracts of Bacillus subtilis spores was stimulated by the addition of not only flavine mononucleotide (FMN) or flavine adenine dinucleotide (FAD) but also alpha-alpha'-dipyridyl or o-phenanthroline. These chelating agents showed stronger effect on the enzyme from spores than on that from vegetative cells. Activity stimulated by alpha-alpha'-dipyridyl or o-phenanthroline was inhibited by atabrine or dipicolinic acid, whereas FMN or FAD stimulation was inhibited only by atabrine.


Tumor induction by immunologically activated murine leukemia virus: cellular immunity early in the graft-vs-host reaction.


Evaluation of T lymphocyte effector function in immunodeficiency diseases: abnormality in mitogen-stimulated interferon in patients with selective IgA deficiency.


Interaction of anti-thymocyte serum with hematopoietic stem cells. I. Effects in vitro and in vivo.


Psychophysiological patterns of response in schizophrenia.


Comments on paper, "Psychophysiological patterns of response in schizophrenia".


Neuroendocrine communication. (Neurohormonal, neurohumoral, and intermediate).


An MMPI scale for assessing death anxiety.


The management of ulcerative colitis.

The management of ulcerative colitis.


National Caries Program. Welcome and introduction.


Topical fluorides and dental caries: a review.


Time series analysis of mosquito population data.


A forecasting model for mosquito population densities.


Laboratory transmission of Lacrosse encephalitis virus by several species of mosquitoes.


Field studies on mosquito-arbovirus relationships in Iowa, 1971.


Health action '72. Brief to the Minister of National Health and Welfare: collective cure for the health care system.


Cardiac arrhythmias of central nervous system origin: possible mechanism and suppression.


Correspondence between Mini-Mult and standard MMPI scale scores in patients with neurological disease.


Reliability and scale equivalence of the Mini-Mult and MMPI.


Depression and suicidality.

Depression and suicidality.


Personality factors associated with over- and undercontrolled offenders.


Coronary aneurysm: isolated necrotizing angitis of a major coronary artery. Report of a case.


Sympathetic beta adrenergic blockade in the preoperative treatment of hyperthyroidism.


How do chemical substances affect the environment?


Biodegradability.

Biodegradability.


A discussion on the assessment of the environmental impact of chemical substances. To what extent can molecular structure point to potential hazards?


The approach of industry to the assessment of environmental hazards.


Carcinogenic hazards in natural and man-made environments.


A multi-national company, the public and the environment.


Environmental information and data handling.


The stimulant action of noradrenaline (alpha-action) on guinea-pig myometrium compared with that of acetylcholine.


Have the Bedouin a special 'desert' physiology?


The evolution of the retinotectal map during development in Xenopus.


Haemodynamic production of lipid deposition, intimal teats, mural dissection and thrombosis in the blood vessel wall.


Intraerythrocytically administered tubercidin (7-deazaadenosine) and immune protection of mice.


Uric acid excretion as an indicator of the amino acid requirement of chicks.


Graft-versus-host reactions in isohistogenic rats.  Frequency and donor-host origin of IgG-containing cells in local intrarenal graft-versus-host reactions.


Pediatric radiology.

Pediatric radiology.


Gamma-glutamyl transpeptidase and 5'-nucleotidase. Comparison as diagnostics for hepatic disease.


The effects of fluroxene and enflurane on contractile performance of isolated papillary muscles from failing hearts.


Antiparkinson drugs as causal agents in tardive dyskinesia.


Letter: Beta-blocking drugs.

Letter: Beta-blocking drugs.


Role of the alpha-receptor in the control of noradrenaline release from sympathetic nerves.


Studies on possible routes of ammonium assimilation in soybean root nodule bacteroids.


Isolation of mutants of Bacillus stearothermophilus blocked in catabolic function.


Using T-groups to train American Indians as physician assistants.


Ethanol administration and the relationship of malonyl-coenzyme A concentrations to the rate of fatty acid synthesis in rat liver. 1. The effect of ethanol on liver fatty acid synthesis was studied in vivo in 24h-starved and ;meal-fed' rats (i.e. fed for 3h per day and not ad libitum). 2. In the fed animal (3)H(2)O was incorporated into fat at a rate of 0.46mumol of C(2) units/min per g wet wt. of liver. Administration of either ethanol (3.2g/kg) or equicaloric amounts of glucose had no effect on the rate of (3)H(2)O incorporation into lipid. 3. In the 24h-starved animal, administration of the same dose of ethanol produced an increase in the rate of (3)H(2)O incorporation from 0.06 to 0.12mumol of C(2) units/min per g fresh wt. after 3h whereas [malonyl-CoA] increased from 0.006 to 0.009mumol/g. Glucose given in amounts equicaloric to ethanol was significantly more lipogenic, increasing both the (3)H(2)O incorporation from 0.06 to 0.20mumol of C(2) units/min per g and the malonyl-CoA content from 0.006 to 0.013 mumol/g wet wt. at 3h. 4. The decrease in the redox state of free cytoplasm NAD or NADP couples or the changes in content of citrate, glucose 6-phosphate and pyruvate of liver after ethanol administration had no measurable effect on the rate of fatty acid synthesis in vivo. 5. Under the conditions of the experiments there was no significant difference, among any of the groups, in the activity of liver fatty acid synthetase measured in vitro. A double-reciprocal plot of the rate of (3)H(2)O incorporation and the total tissue malonyl-CoA concentrations showed a striking relationship. It has been concluded that the rate of fatty acid synthesis in vivo is determined principally by the V(max.) of fatty acid synthetase and the concentration of free malonyl-CoA. 6. It has also been concluded that under the conditions of the present study, the synthesis of fatty acids de novo is unlikely to be an important factor in the increased liver lipid content associated with ethanol administration.


Metabolic adaptations during lactogenesis. Fatty acid and lactose synthesis in cow mammary tissue. 1. Mammary-tissue biopsies were obtained from multiparous cows at 30 and 7 days pre partum and 7 and 40 days post partum. Investigations of the effect of lactogenesis on fatty acid and lactose synthesis involved measurements of biosynthetic capacity (tissue-slice incubations in vitro) and activities of relevant enzymes. 2. Fatty acid synthesis from acetate increased over 20-fold from 30 days pre partum to 40 days post partum. Changes in the lipogenic capacity of mammary-tissue slices more closely paralleled increases in the activities of acetyl-CoA carboxylase (EC 6.4.1.2) and acetyl-CoA synthetase (EC 6.2.1.1) than of other enzymes involved in acetate incorporation into fatty acids or in NADPH generation. 3. Lactose biosynthesis by mammary-tissue slices, lactose synthetase activity (EC 2.4.1.22) and alpha-lactalbumin concentration were all negligible at 30 days pre partum but increased 2.5-4-fold between 7 days pre partum and 40 days post partum. Phosphoglucomutase (EC 2.7.5.1), UDP-glucose pyrophosphorylase (EC 2.7.7.9) and UDP-glucose 4-epimerase (EC 5.1.3.2) had substantial activities at 30 days pre partum and increased less dramatically during lactogenesis. 4. Results are consistent with acetyl-CoA carboxylase and perhaps acetyl-CoA synthetase representing the regulatory enzyme(s) in fatty acid synthesis, with lactose synthetase (alpha-lactalbumin) serving a similar function in lactose biosynthesis.


Graded responses in ciliary activity of ctenophores compared with the "staircase" of cardiac muscle.


Diet and dental caries: dental caries incidence and the consumption of ready-to-eat cereals.


Distal condylar fractures of the cannon bone in the horse.


Stress induced inhibition of jejunal crypt cell proliferation.


Regulation of gene expression by hormones during the mammalian cell cycle.


Mechanism of calcium induction of Renilla bioluminescence. Involvement of a calcium-triggered luciferin binding protein.


Immunofluorescent studies of lymphoid tissue in Hodgkin's disease.


Symposium: Immunological aspects of Hodgkin's disease. Concluding remarks.


A new concept of immunoregulation and its application to leukemia and lymphoma.


Some aspects of the immunology of Hodgkin's disease.


The Stokes-Adams syndrome.

The Stokes-Adams syndrome.


Beta adrenergic blocking drugs in the treatment of cardiac arrhythmias.


Combination antihypertensive therapy.

Combination antihypertensive therapy.


Editorial: A new interpretation of the major histocompatibility gene complexes of man and mouse.


Immunity and tolerance: a unified concept.


Studies on immunological paralysis. VI. Thymic-independence of tolerance and immunity to type 3 pneumococcal polysaccharide.


Editorial: New types of health professionals for developing and developed countries.


The role of the symbiotic algae of Plexaura homomalla in prostaglandin biosynthesis.


Effects of some beta adrenergic blocking agents on tremorine induced tremor, hypothermia and cholinergic effects in rats.


Selected topics on the biochemistry of spermatogenesis.


Ultraviolet spectrophotometry of phenothiazine derivatives and analogs.


Structure and function of D-amino acid oxidase. VII. Interaction of hydrophobic probes with D-amino acid oxidase.


The effects of personality tests on state and trait anxiety.


Concurrence of psychiatric diagnosis and psychological diagnosis based on the MMPI.


Two different NADH dehydrogenases in respiration of Rhodospirillum rubrum chromatophores.


MMPI X and Zero items in a psychiatric outpatient group.


Differential misdiagnosis of blacks and whites by the MMPI.


Polyps of the colon.

Polyps of the colon.


Foot infection in the elderly.

Foot infection in the elderly.


Metabolism and functions of cyclic AMP in nerve.


Multimodality treatment of the hyperkinetic child.


Letter: The effect of benztropine mesylate on plasma levels of butaperazine maleate.


A human model of coal tar acne.

A human model of coal tar acne.


Direct arterial pressure and the electrocardiogram in unrestricted patients with angina pectoris.


Antihypertensive and hemodynamic properties of the new beta adrenergic blocking agent timolol.


New drugs of 1970.

New drugs of 1970.


Effect of handling in infancy on responsiveness of adrenal tyrosine hydroxylase in maturity.


Oxidative metabolism of carbon disulphide by the rat. Effect of treatments which modify the liver toxicity of carbon disulphide.


Omega-oxidation of stearic acid in the normal, starved and diabetic rat liver.


Enzymatic characteristics of CO-sensitive 26-hydroxylase system for 5beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol in rat-liver mitochondria and its intramitochondrial localization.


Need for statutory legitimation of the roles of physician's assistants. A significant constraint on new categories of health manpower is the absence of statutory legitimation of their roles. Licensure has been evolved as an effort to assure high-quality health care, but recently it has been a barrier to effective and innovative use of manpower. Medical and Nurse Practice Acts generally define the practices of medicine and nursing, but they do not define clearly the scope of these practices. Thus, these acts subject physicians to undue risks in delegating responsibilities and Type A assistants (nurses or non-nurses with special training) to undue risks in accepting those functions. Furthermore, only vague guidelines are provided to protect the public and to assure adequate quality control. To date, 35 States have enacted legislation to provide statutory legitimation of Type A assisants and to permit physicians to delegate appropriate responsibilities to new types of health manpower. It is hoped that this legislation will diminish barriers to effective use of health manpower.


Difference between the lymph node response to injection of autosensitized T lymphocytes and that in a graft-versus-host reaction.


Editorial: The real gap between bench and bedside.


Transformation by simian virus 40 of spleen cells from a hyperimmune rabbit: evidence for synthesis of immunoglobulin by the transformed cells. Spleen cells derived from a rabbit hyperimmunized with a Type III pneumococcal vaccine were exposed to simian virus 40 in vitro. After 114 days, transformed cells growing on the surface of one culture dish were observed and a cell line was established. The transformed cells had a morphology characteristic of cells transformed by simian virus 40, contained the simian virus 40-specific T antigen, and yielded infectious simian virus 40 upon cultivation with indicator cells in the presence of Sendai fusion factor. Transformed cells incorporated labeled amino acid into protein with the antigenic properties of rabbit immunoglobulin G.


Transformation by simian virus 40 of spleen cells from a hyperimmune rabbit: demonstration of production of specific antibody to the immunizing antigen. Extracts of spleen cells obtained from a rabbit hyperimmunized with Type III pneumococcal vaccine and transformed with simian virus 40, were subjected to agarose gel electrophoresis in the presence of an [(125)I]S3 polysaccharide-protein conjugate. Binding of radioactivity in the gamma globulin region was observed. Extracts and media obtained from labeled cell cultures contained a protein that bound to an S3, but not to an S8 or inactivated S3 immunoadsorbent. After elution, the bound protein showed a single band on isoelectric focusing which corresponded in isoelectric point to one of the serum anti-S3 antibodies of the donor rabbit. These observations strongly suggest that a normal committed lymphoid cell may be brought into continuous culture by virus transformation and yet retain its ability to synthesize specific antibody.


Formation of 5-oxoproline from glutathione in erythrocytes by the gamma-glutamyltranspeptidase-cyclotransferase pathway. gamma-Glutamyltranspeptidase activity was demonstrated in the membrane fraction of rabbit erythrocytes. The activity observed (with glutathione and various amino-acid acceptors) was similar in magnitude to that of the gamma-glutamylcyclotransferase and gamma-glutamylcysteine synthetase activities found in the soluble fraction of the cell. No transpeptidase activity was observed with either gamma-glutamyl p-nitroanilide or oxidized glutathione in contrast to the rabbit-kidney enzyme for which these compounds and glutathione serve as substrates. Erythrocyte suspensions and hemolysates formed 5-oxoproline (pyroglutamate; pyrrolidone carboxylate); the rate of 5-oxoproline formation from glutathione by hemolysates was increased by addition of methionine. The findings indicate that 5-oxoproline is an end-product of glutathione metabolism in erythrocytes, and that 5-oxoproline passes out of the erythrocyte and is metabolized in other tissues. The observed rate of 5-oxoproline formation is consistent with the conclusion that the gamma-glutamyltranspeptidase-cyclotransferase pathway, together with the synthesis of glutathione from glycine, cysteine, and glutamate, account for a large fraction of the observed amino-acid turnover of erythrocyte glutathione.


Inhibition of bacterial growth by beta-chloro-D-alanine. The D- and L-isomers of beta-chloroalanine inhibit the growth of Diplococcus pneumoniae, Streptococcus pyogenes, Bacillus subtilis, and Escherichia coli. With pneumococcus the inhibition by beta-chloro-D-alanine is completely prevented by either D-alanine or D-alanyl-D-alanine, while L-alanine is not effective in preventing the inhibition. The inhibition of growth by beta-chloro-L-alanine is not affected by D-alanine and is only partially prevented by high concentrations of L-alanine. The intracellular free alanine in untreated E. coli and B. subtilis is about 95% in the D-configuration while the free intracellular alanine in both organisms after treatment with beta-chloro-D-alanine is predominantly the L-isomer. These results suggested that the beta-chloroamino acid inactivates alanine racemase (EC 5.1.1.1). Indeed, when extracts of E. coli or B. subtilis were treated with beta-chloro-D-alanine, the activities of alanine racemase and of D-glutamate-D-alanine transaminase were found to be 90-95% inhibited. Studies with mice have shown that beta-chloro-D-alanine is an effective antibacterial agent in vivo againt D. pneumoniae, S. pyogenes, and E. coli.


The effect of beta-adrenergic blocking agents on the rat adrenal phenylethanolamine-N-methyltransferase activity.


Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids. A fraction containing capillaries and rich in gamma-glutamyl transpeptidase was isolated from homogenates of bovine brain cortex by density gradient centrifugation. The enzyme was localized in the endothelial cells by a histochemical procedure. gamma-Glutantyl transpeptidase may function in the transfer of some amino acids across the blood-brain barrier.


Gel chromatographic purification of rabies virus on wide-pore glass.


Concentration of echoviruses by polyethylene glycol.


Evaluation of beta-adrenolytic properties of N,N'-bis-(3-(p-methoxyphenoxy)-2-hydroxypropyl)-ethylenediamine and its N,N'-dimethyl derivative.


Paralytic sequelae and immunologic response of infant mice after infection with viruses of the Tacaribe group.


Interferon in young and aged chick embryo cell cultures infected with herpes simplex and pseudorabies viruses.


Interferon induction by detoxicated bacterial endotoxins.


Interferon induction by, and antiviral effect of poly (rI)--poly (rC) in experimental viral infection.


Genetic interaction between two influenza A-WS virus mutants. 3. Capacity of WS-NWS recombinants to reproduce in various cell systems.


Susceptibility of Anopheles gambiae mosquito cell line (MOS 55) to some arboviruses.


Survival of small amounts of Coxsackie A4 virus in Danube river water under laboratory conditions.


Changes in isoelectric points of chromatin deoxyribonucleoproteins from Krebs II cells after infection with encephalomyocarditis virus.


Thoracic duct lymph and blood of mice at early stages of Tahyńa and Semliki Forest virus infections.


Ataxia-telangiectasia (Louis Bar syndrome): with special reference to findings in the peripheral nervous system.


Comparison of antibody-binding and antibody-inducing capacities of phase I and phase II Coxiella burneti antigens.


Mechanisms involved in the trans-synaptic increase of tyrosine hydroxylase and dopamine-beta-hydroxylase activity in sympathetic ganglia.


Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission.


Effect of prostaglandins on fatty acid metabolism in lung.


Photometric method for determination of doubly specific influenza antibody.


Studies on group A (phage tail) bacteriocins of Serratia marcescens. I. Phenotypic variation of producer and indicator strains.


Identification of 38 mycoplasma strains isolated from the vagina of dogs.


Linear theory of enzymatic chains; its application for the analysis of the crossover theorem and of the glycolysis of human erythrocytes.


Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality.


Health centre practice in Livingston New Town.


Medical assistants. Can AAMA help you?

Medical assistants. Can AAMA help you?


Inhibition by tetrahydroharmane compounds of 5-hydroxytryptamine and histamine uptake in rabbit blood platelets.


Inhibition of monoamine uptake in synaptosomes by tetrahydroharmane and tetrahydroisoquinoline compounds.


Does burimamide inhibit gastric acid secretion by a release of catecholamines?


On the mechanism of the synergistic effect of perazine and hexobarbital.


Increased synthesis of adrenomedullary catecholamines induced by caffeine and theophylline.


Another utilization of MESA in the evaluation-grading of a class of Medex trainees.


Objective diagnostic tests and measures.


The effects of steroid and gonadotrophic hormones in vitro on the metabolic activity of normal and cryptorchid rat testicular tissues.


Enzymatic and mechanical requirements for the dissociation of cortical cells from rat adrenal glands.


Further evidence of the similarity of microtubule protein from mitotic apparatus and sperm tail of the sea urchin, as a substrate in thiol-disulfide exchange reaction.


Mechanism of adrenergic neuron blocking effects of propranolol & pronethalol.


The use of allied health workers by general practitioners in various situations.


Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase. Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.


Experimental selection of influenza virus mutants (subtype A0 and A1): haemagglutinin.


Graft-versus-host disease.

Graft-versus-host disease.


Comparison of oral health in four Canadian Indian communities.


Studies on the mercury resistance of staphylococci.


Actinobacillus lignieresii human infection.


Effect of dipicolinic acid on the haemolysis of human red blood cells.


Regional lymph node response in rats to injection of semi-allogeneic lymphocytes. Time, weight, dose, and histocompatibility relations.


Regulation of glutamine synthetase adenylylation and deadenylylation by the enzymatic uridylylation and deuridylylation of the PII regulatory protein.


Purification and properties of two ferredoxins from the nitrogen-fixing bacterium Bacillus polymyxa.


Studies of mitochondrial energy systems during embryogenesis in the rat.


Gastric aspiration and lavage.

Gastric aspiration and lavage.


Kinetic studies of a NADP+-specific isocitrate dehydrogenase from Salmonella typhimurium. Purification and reaction mechanism.


Lipid peroxidation and the degradation of cytochrome P-450 heme.


The use of emetics in poison ingestion.

The use of emetics in poison ingestion.


Drug alert--syrup of ipecac.

Drug alert--syrup of ipecac.


Disposition and anticonvulsant activity of bromazepam in mice.


The N-hydroxylation of phentermine (2-methyl-2-amino-1-phenylpropane). Properties of the enzyme system.


Denitration of unconjugated and conjugated pentaerythritol nitrates by rat liver cytosol.


Isolation of pentaerythritol nitrates and their glucuronides.


Medico-legal brief: physician liability for health care assistants.


Oxygenated norethindrone derivatives from incubation with beagle liver. Structure, synthesis, and biological activity.


Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies.


Neural cardiovascular control and hypertension.


The role of gut flora in the reduction of aromatic nitro-groups.


Drug-induced extrapyramidal syndromes.

Drug-induced extrapyramidal syndromes.


The acetylator phenotype of patients with systemic lupus erythematosus.


Stereoselective biotransformations of dl-norgestrel and its enantiomers in the African green monkey.


The interactions of inducers, inhibitors, and substrates of drug-metabolizing enzymes with rat liver cytochrome P-450.


Action of anticholinergic and related agents on single vestibular neurones.


Increase in adrenal monoamine oxidase activity in hypophysectomized rats after ACTH.


Studies on human placental carbon monoxide-binding cytochromes.


Drugs acting on the heart.

Drugs acting on the heart.


Enzyme activities related to fatty acid synthesis in developing mammalian lung.


The phenylalanine hydroxylating system from mammalian liver.


The biotin-dependent enzymes.

The biotin-dependent enzymes.


Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man.


Studies on the activity of some enzymes in allergic bronchial asthma.


Behavior and electrical activity in the hydrozoan Proboscidactyla flavicirrata (Brandt). I. The hydroid colony.


Photoperiodic control of development in Chaoborus americanus with special reference to photoperiodic action spectra.


The effect of fluphenazine in psychologically normal volunteers: some temporal, performance, and biochemical relationships.


A laboratory comparison of Copper Kettle, Fluotec Mark 2, and Pentec vaporizers.


Investigation of heterotopically transplanted dog hearts after preservation.


Use of chemotherapy as anti-suicidal prophylaxis.


Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora.


Emergency care of acute poisonings.

Emergency care of acute poisonings.


Effect of human chorionic gonadotrophin on plasma and urine testosterone in boys with delayed puberty.


Plasma and urine testosterone responses to human chorionic gonadotrophin (HCG) in children with delayed puberty.


Pacemaker-induced hypotension for intracranial aneurysm surgery.


Nurse practitioner, family practice nurse or physician's assistant.


Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines.


An in vitro and pharmacological comparison of amoxicillin and ampicillin.


Hypergastrinemia in familial multiple endocrine adenomatosis.


Localization of gamma-glutamyl transpeptidase in rabbit lens,  ciliary process and cornea.


Mode of action of a staphylococcal anti-inflammatory factor.


Stand up and be counted.

Stand up and be counted.


An unusual presacral tumor.

An unusual presacral tumor.


Pancreatic transplantation for diabetes mellitus.


Clinical conference: bronchogenic cyst.

Clinical conference: bronchogenic cyst.


Detection of breast cancer. A review of cancer registry from Blessing Hospital, Quincy.


An ambulance strategy for Illinois.

An ambulance strategy for Illinois.


"Where have all the doctors gone"?

"Where have all the doctors gone"?


Are you satisfied with your CME?

Are you satisfied with your CME?


The hospital practice of medicine.

The hospital practice of medicine.


The viewbox.

The viewbox.


Editorial: Opportunistic infection.

Editorial: Opportunistic infection.


Editorials: Against medical advice.

Editorials: Against medical advice.


MEDICHEK--the Illinois program of early periodic screening, diagnosis and treatment--what is it?


EKG of the month.

EKG of the month.


Surgical grand rounds: intussusception in an adult.


The anesthesiologist and the intensive care unit.


Anesthesiologist-hospital relationships.


Anesthesiologist-surgeon relationships.

Anesthesiologist-surgeon relationships.


Effect of B-cell mitogens on lymphocyte subpopulations possesing C'3 and Fc receptors. By the use of a rosette method allowing the detection at the cellular level of lymphocytes simultaneously binding Fc- and C'3-sensitized red cells it was found that about 70% of the rosette-forming cells from spleens of nude and normal mice possessed receptors for both Fc and C'3, whereas 30% only had Fc receptors. Very few, if any, lymphocytes possessed only C'3 receptors. The B-cell mitogens, purified-protein derivative of tuberculin (PPD), lipopolysaccharide from Escherichia coli (LPS), and pneumococcal polysaccharide type SIII (SIII), induced marked changes of these receptor-bearing lymphocytes. PPD caused a rapid loss of cells capable of binding C'3 and a concomitant increase of only Fc-binding cells, which was detected after only 24 h. LPS and SIII induced analogous changes, but they were not detected until 48 h and were not complete until after 72 h. It is suggested that immature lymphocytes possess both Fc and C'3 receptors and lose the latter receptor upon differentiation induced by B-cell mitogens PPD. and LPS would affect different populations of B cells, PPD-activating cells that have already reached a higher differentiation stage, whereas LPS and SIII would activate more immature B cells.


Otitis externa.

Otitis externa.


Electrophysiologic effects of dopamine on sheep cardiac Purkinje fibers.


External otitis: otological problems.

External otitis: otological problems.


Phenylalanine to tyrosine ratio in renal failure.


Clinical aspects of the anti-arrhythmic actions of beta-receptor blocking drugs. 2. Clinical pharmacology.


Morphology of deep and superficial venous thrombosis and of thrombosis due to panphlebitis.


[Effects of vaso-active drugs on the full-thickness skin autograft 1. Effect on plasma inhibition].


A kinetic study of the effects of sympatholytic agents on the responses to field stimulation in guinea-pig atrium.


Some pharmacological characteristics of ganglionic activity of lobeline.


[Pharmacokinetics and metabolism of fominoben (Noleptan) in man].


[Report on a preliminary open clinical study of mianserin (GB 94), a tetracyclic antidepressant].


Three generations of selection for high and low donor competences of splenomegaly in chickens.


Interference in the Zimmerman test for steroids.


Potentiometric evidence for the active transport of sodium and chloride across excised gills of Callinectes sapidus.


The effect of anaemia on ion exchange in the southern flounder (Paralichthys lethostigma).


Temperature regulation of the little brown bat, Myotis lucifugus after acclimation at various ambient temperatures.


Responses to low oxygen conditions in two species of the mud snail Nassarius.


Some physiological responses to anoxia in the great plains toad, Bufo cognatus.


Absolute duration of survival of Tammar wallaby (Macropus eugenii, Marsupialia) on sea water and dry food.


Osmoregulation in the pink shrimp Penaeus duorarum Burkenroad.


Temperature-dependent shifts in the metabolism of a cool temperate reptile, Thamnophis sirtalis parietalis.


Regulation of the ventilation-perfusion ratio in the gills of Dasyatis sabina and Squalus suckleyi.


The chromatic physiology of the catfish Ictalurus melas (Rafinesque). I. The melanophore responses of intact and eyeless fish.


Energy utilization and water requirements of captive Myotis thysanodes and Myotis lucifugus (Chiroptera).


Hormonal regulation of rat liver cells cultured in chemically defined medium. Dexamethasone and insulin effects on different forms of tyrosine 2-oxoglutarate transaminase.


ODA lay conference on prevention of dental disease.


Accelerated medical graduates studied.

Accelerated medical graduates studied.


The relationship of the metabolism of anticancer agents to their activity.


Role of alpha-adrenoceptors in prostaglandin E mediated negative feedback control of the secretion of noradrenaline from the sympathetic nerves of isolated guinea-pig vas deferens.


Microassay of tyrosine-amino transferase and p-hydroxyphenylpyruvic acid oxidase in mammalian liver and patients with hereditary tyrosinemia.


Drugs for angina pectoris.

Drugs for angina pectoris.


Biogenesis of mitochondria. 20. The effects of altered membrane lipid composition on mitochondrial oxidative phosphorylation in Saccharomyces cerevisiae.


The ICU and collegiate nursing education.


A durohydroquinone oxidation site in the mitochondrial transport chain.


Contribution of inhibition of NADH-dehydrogenase to the cardiotoxic effects of halothane.


Guided reading: a strategy to enhance learning.


Research for the undergraduate student in nursing.


Change processes should involve baccalaureate nursing students.


Evaluation of faculty and students--a means towards fuller communication and greater productivity.


Teaching organizational concepts to nurses in community mental health.


The role of taste in disease and drug therapy and certain drug-nutrient interactions.


Harkavy's syndrome.

Harkavy's syndrome.


Prostaglandin-like activity of various fractions of ram semen: their role in the immune rejection of the nematode Nippostrongylus brasiliensis from the small intestine of rats.


Posthepatitic severe aplastic anemia--an indication for early bone marrow transplantation.


Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide. Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence of H(2)-receptors. Mepyramine or burimamide alone produced partial antagonism of histamine-induced relaxation of the cat trachea. Both inhibitors added simultaneously effectively abolished the histamine response, suggesting that both H(1)- and H(2)-receptors are active in relaxing the cat trachea.


Effect of alpha-blocking drugs in asthma.


Clinical and pharmacokinetic studies of minoxidil, a new antihypertensive agent.


Blood pressure over-shoot due to acute clonidine (Catapres) withdrawal: studies on arterial and urinary catecholamines and suggestions for management of the crisis.


Plasma renin and angiotensin levels in human hypertension following treatment.


A new look at the treatment of severe hypertension.


Comparison of the in vitro deiodination of 125-I-, 127-I-, and 131-I-diiodotyrosine by thyroid and liver homogenates and slices from rat and pig.


On the rhodopsin cycle.

On the rhodopsin cycle.


Use of photoreceptor membrane suspensions for the study of rhodopsin and associated enzyme activities.


Selenium in relation to dental caries.

Selenium in relation to dental caries.


Treatment of external diseases with immunological properties.


Mannoheptulose and fatty acid synthesis in the rat.


Letter: Substrate specificity of monoamine oxidase activity in various mouse and rat tissues.


Letter: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens.


Letter: Effect of pH on the release of noradrenaline from micropipettes.


Letter: Antagonism of central dipsogenic and peripheral vasoconstrictor reponses to angiotensin II with Sar Ala8 angiotensin II in the conscious cat.


Letter: Post-synaptic blockade of dopaminergic transmission by 6-hydroxydopamine.


Letter: Methadone N-oxide in the urine of methadone maintenance subjects--an artifact?


Letter: Similarity between the effects of dimethyl and monomethyl tricyclic drugs on reserpine effects in the frog and 5-hydroxytryptamine uptake by human blood platelets.


Letter: Biphasic responses to guanosyl nucleotides in two smooth muscle preparations.


Letter: A new chemotherapeutic property of metronidazole: effect against oxyurids in mice.


Letter: Release of (3H)noradrenaline and (3H)metaraminol from rabbit pulmonary artery in vitro.


Electron transport system in human leukocyte mitochondria.


Letter: Myocardial depressant action of ethyl acetate.


Letter: Brain adenyl cyclase in methadone treatment of morphine dependency.


Letter: A simple screening test for drugs of potential use in ethanol withdrawal.


Studies on the nature of the increased monoamine oxidase activity in the rat heart after adrenalectomy.


The pharmacology of azidomorphine and azidocodeine.


Chemical composition and potential activity of Argentine marihuana.


The distribution of delta1-tetrahydrocannabinol and 7-hydroxy-delta-tetrahydrocannabinol in the mouse brain after intraventricular injection.


The binding of paracetamol to plasma proteins of man and pig.


Dissolution and bioavailability of digoxin tablets.


Determination of the thermodynamics of hydroxyl and carboxyl groups in solutions of drug molecules.


An analogue computer study of the dialysis of salicylic acid from micellar solutions of polysorbate 20 and 80.


Kinetics of three structurally related bicyclic antidepressant compounds--a comparison in the dog.


A note on the chemical change of pentazocine in aqueous acidic media.


Letter: Salbutamol and inhibition of uterine contractions.


Letter: The influence of substrates and buffer solutions on the estimation of monoamine oxidase activity.


Letter: Securinine.

Letter: Securinine.


An alternative staffing proposal for emergency rooms. Three-year experience in a rural hospital.


Secretory characteristics of pancreatic gamma-glutamyl transpeptidase.


A method for measuring mental performance in the elderly and its use in a pilot clinical trial of meclofenoxate in organic dementia (preliminary communication).


A study of the antiarrhythmic action of certain beta-blocking agents.


Editorial: Turner's and Noonan's syndromes.


A correlational study of the community adaptation schedule and the Minnesota Multiphasic Personality Inventory.


Monitoring depth of anesthesia.

Monitoring depth of anesthesia.


Studies on prolactin inhibition of thyroxine-induced metamorphosis in Rana catesbeiana tadpoles.


Interview: Russell B. Roth, M.D., president of the American Medical Association.


Cannabis-induced psychosis.

Cannabis-induced psychosis.


Post-mortem findings in East African birds of prey.


Relationship between plasma antipyrine half-lives and hepatic microsomal drug metabolism in dogs.


Azaperone and the hepatic microsomes: effects on cytochrome P-450 concentration and on NADPH-cytochrome c-reductase activity.


Cyclic GMP.

Cyclic GMP.


Metiamide--an orally active histamine H2-receptor antagonist.


Studies on the mode of action of histamine H1- and H2-receptor antagonists on gastric histamine methyltransferase.


Effect of burimamide on gastric acid secretion and gastric mucosal blood flow in cats.


Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine: inhibition of histamine methyltransferase in vivo?


Similar actions of methylated histamines and histamine receptor antagonists on gastric histamine methyltransferase.


Pharmacological studies on the role of histamine in thermoregulation.


Immunserum to a protein which reduces the biological activity of histamine.


The influence of imidazole and some of its derivatives on isolated guinea-pig's heart auricles.


The influence of burimamide on 14C-histamine uptake and metabolism by guinea pig atrium and mouse neoplastic mast cells, in vitro.


Modifications of brain HA metabolism induced by antihistamines.


Effect of burimamide on histamine metabolism.


Electroencephalographic, behavioural and visceral effects of intraventricular infusion of histamine in the rabbit.


Cardiovascular effects of a newer antiarrhythmic agent, disopyramide phosphate.


Low tension glaucoma.

Low tension glaucoma.


Glutamine synthetase of pea leaves. I. Purification, stabilization, and pH optima.


Studies on the assay and activities of guanyl and adenyl cyclase of rat liver.


Control of cytochrome P-450 in rat testis mitochondria by human chorionic gonadotrophin.


Purification and some properties of a protein factor required for light-dependent transhydrogenase in Rhodopseudomonas spheroides.


Isocitrate dehydrogenase from Rhodopseudomonas spheroides: kinetic mechanism and further characterization.


Change of activity and substrate specificity of human glucose 6-phosphate dehydrogenase by oxidation.


The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma.


Therapeutic implications of the drug lag.


Management of congenital defects of the anterior abdominal wall.


Ulcerative colitis. Selected clinical, diagnostic and therapeutic aspects. II.


Studies on the function of cell membrane. 6th report. Influence of sex hormones on the elevation of NADH-cytochrome c reductase activity in liver plasma membrane of CCl4-administered rats.


Studies on the function of cell membrane. 7th report. Influence of CCl4 administration of solubilization of the enzymes in electron transport system in rat liver plasma membrane and microsome.


Studies on monoamine oxidase. Report 22. Effects of NaNO2 and NH2OH on mitochondrial MAO in rat brain.


Beta-adrenergic blocking action of ruthenium red.


New isothiazole derivatives. 3. Influence on glucose consumption and lactic acid production in tissue cultures.


Multiple endocrine adenomatosis.

Multiple endocrine adenomatosis.


Studies on bile secretion in man. I. Choleresis and composition of bile during basal secretion.


Classification and properties of peripheral adrenergic receptors.


Erythrocytic nicotinamide-adenine dinucleotide phosphate levels and the genetic regulation of erythrocytic glucose 6-phosphate dehydrogenase activity in the inbred mouse.


Adrenergic drugs in the treatment of hypertension.


Pharmacologic control of premature labor.


Enzyme induction in human fetal liver in organ culture.


Studies of glutamate dehydrogenase. The binding of NADH and NADPH to beef-liver glutamate dehydrogenase.


Histochemical and ultrastructural study of muscle biopsies in 3 cases of dystrophia myotonica in the newborn child.


Destruction of low efficiency markers is a slow process occurring at a heteroduplex stage of transformation.


Pathology of 'pseudotumours' of the orbit: a review.


Malnutrition and oral health of children.


Intracellular competition for a mismatch recogition system and marker-specific rescue of transforming DNA from inactivation by ultraviolet irradiation.


Epsilon-adenylylated glutamine synthetase: an internal fluorescence probe for enzyme conformation. A fluorescent derivative of ATP, epsilon-ATP, was used to adenylylate glutamine synthetase (EC 6.3.1.2) from Escherichia coli enzymatically. The epsilon-adenylylated enzyme exhibits similar catalytic properties and inhibitor susceptibility to those of the naturally adenylylated enzyme. The fluorescence properties of the epsilon-adenosine and of tryptophan residues of the enzyme were used to study ligand-induced conformational changes involving alterations of the tryptophan regions and the adenylylation site of the protein. Binding of Mn(2+) to the epsilon-adenylylated enzyme is accompanied by a decrease of epsilon-adenosine fluorescence as compared to the effect observed for the Mg(2+) binding. An ADP binding study shows that at low ADP concentration, ADP causes enhancement of the tryptophan fluorescence only, reflecting the binding to unadenylylated subunits; and at high ADP concentration, ADP causes not only enhancement of the fluorescence, but also a quenching of the fluorescence of enzyme-bound epsilon-AMP, reflecting binding to the adenylylated subunits. Dissociation constants calculated from these fluorescence changes agree well with those determined from binding studies of ADP to adenylylated and unadenylylated enzymes. Binding of the feedback inhibitor, alanine, to Mn(2+)-dependent glutamine synthetase causes enhancement of the epsilon-AMP fluorescence, from which a dissociation constant of 1.5 mM was calculated for the inhibitor. The fluorescence changes observed due to ligands binding suggest that Mg(2+) and Mn(2+) stabilize different conformational states of the enzyme.


Differences in Australia antigen carrier rates in northern Nigeria.


Biting insect survey: a statistical report.


Oral theophylline preparations--a review of their clinical efficacy in the treatment of bronchial asthma.


The nature of treatment selection in coronary artery disease. Experience with medical and surgical treatment of a chronic disease.


Acute myocardial infarction and muscle salvage: a potential role for pharmacological agents.


Studies on chromatin-associated protein phosphokinase of submandibular gland from isoproterenol-treated rats.


Activity of some hydrolases in animals with transplanted and spontaneous tumours.


The physician's assistant in GEorgia.

The physician's assistant in GEorgia.


Polysaccharides of the genus Bacillus cross-reactive with the capsular polysaccharides of Diplococcus pneumoniae type 3, Haemophilus influenzae type b, and Neisseria meningitidis group A. We studied 174 strains of the genus Bacillus for cross-reacting antigens to the capsular polysaccharides of groups A and C meningococcus, types I and III pneumococcus, and Haemophilus influenzae type b. Cross-reactions were detected by immunodiffusion in agarose gel by using type-specific antisera and confirmed by absorption and inhibition experiments. Of 20 Bacillus pumilis strains, six had an antigen cross-reacting with group A meningococcal polysaccharide. Other cross-reactions included one strain of B. pumilis with H. influenzae type b, one of B. cereus var. mycoides with pneumococcus type III, and one of B. alvei with both type b and SIII polysaccharides. These cross-reacting antigens are polysaccharides of vegetative cells and may be extracellular in location. Because these bacilli have antigens cross-reacting with the virulence factors of pyogenic bacteria, they may, as normal flora, be an antigenic stimulus for "natural" serum anti-capsular antibodies to the type b Haemophilus and group A meningococcus polysaccharides.


Filamentous capsulated streptococci from the human respiratory tract. I. Antigenic attributes of provisional capsular type 83 and its relationship to streptococci of so-called group M. Two immunologically reactive polysaccharides have been isolated from the cell walls and from culture filtrates of a filamentous alpha-hemolytic streptococcus provisionally designated capsular type 83. Both polysaccharides were purified by diethylaminoethyl-cellulose chromatography. Analysis indicates that the capsular polysaccharide consists of galactose and phosphorus, whereas the cell wall polysaccharide contains galactosamine, glucosamine, glucose, and phosphorus. On the basis of immunochemical experiments, it is suggested that the capsular polysaccharide is composed of galactose-phosphate units with terminal galactose residues at the nonreducing end. It has also been found that the capsular antigen of streptococcus type 83 is shared by a number of streptococcal strains classified in Lancefield's group M. The cell wall polysaccharide of streptococcus type 83 cross-reacts with antibody to the C(s), or cell wall-like capsular, polysaccharide of Diplococcus pneumoniae, and this cross-reactivity may be a reflection that the streptococcal antigen possesses certain structural features which are similar to those of pneumococcal C and C(s) polysaccharides.


Filamentous capsulated streptococci from the human respiratory tract. II. Antigenic structure of provisional capsular types 89 and 83-89. Two immunologically distinct polysaccharides have been isolated from the filamentous alpha-hemolytic streptococcus of provisional capsular type 89, recovered from the human respiratory tract. Chemical analyses indicate that the capsular polysaccharide consists of glucose, galactose, and a small amount of rhamnose, whereas the cell wall-associated polymer contains galactosamine, glucosamine, glucose, and phosphorus. Immunological studies suggest that the capsular polysaccharide is type specific and that the cell wall-associated carbohydrate, which cross-reacts with the C(8), or cell wall-like capsular polysaccharide of pneumococcus, may be group specific. A noncapsulated variant of the prototypic streptococcus of provisional type 89 was shown to possess the same cell wall-associated carbohydrate as the strain from which it was derived, but it proved to be poorly antigenic in rabbits. A filamentous capsulated streptococcus reacting with antisera to filamentous streptococci of both provisional capsular types 83 and 89 has been found to produce two capsular polysaccharides, each of which reacts with antibody to one of the aforementioned unitypic strains and represents an unusual binary capsulated streptococcus.


Filamentous capsulated streptococci from the human respiratory tract. 3. Immunochemical studies of the cross-reactivity between the cell wall antigens of a filamentous streptococcus and of pneumococcus. A cell wall-associated polysaccharide has been isolated from a noncapsulated mutant, 89R50, of the alpha-hemolytic filamentous streptococcus of provisional capsular type 89. Chemical analysis of the polysaccharide indicates that it consists of galactosamine, glucosamine, glucose, and phosphorus. Immunological cross-reactivity was observed between the streptococcal cell wall antigen and antibody to the cell wall-like capsular polysaccharide of pneumococcus. This cross-reactivity appears attributable to similarities in the teichoic acid moieties rather than in the mucopeptide moieties of the two polymers. No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor. It is suggested that antibody to this cell wall polysaccharide might serve as a basis for grouping other filamentous strains of streptococci of diverse capsular types, the cell wall antigens of which show similar cross-reactivity with that of pneumococcus.


Effects of neuroleptanesthesia on catecholamines.


Prostaglandin metabolism. I. Cytoplasmic reduced nicotinamide adenine dinucleotide phosphate-dependent and microsomal reduced nicotinamide adenine dinucleotide-dependent prostaglandin E 9-ketoreductase activities in monkey and pigeon tissues.


Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. V. Studies with the Escherichia coli hemoflavoprotein depleted of flavin mononucleotide: distinct roles for the flavin adenine dinucleotide and flavin mononucleotide prosthetic groups in catalysis.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme.


Dental materials which can be used to reduce caries in fissures.


The effect on caries increments in dental students of topically applied acidulated phosphate fluoride (APF).


Diagnosis of bacterial diseases by detection of serum antigens by counterimmunoelectrophoresis, sensitivity, and specificity of detecting Pseudomonas and pneumococcal antigens.


Choice of antihistamines.

Choice of antihistamines.


Glutathione peroxidase activity as a function of dietary selenomethionine.


Regional action to strengthen continuing education in nursing. Commentary on Southern Regional Education Board Council on Collegiate Education for Nursing 20th meeting, October 31 - November 2, 1973, Atlanta, Georgia.


Necrotizing myelitis: a clinico-pathologic report of two cases associated with diplococcus pneumoniae and mycoplasma pneumoniae infections.


Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides.


Pharmacologial analysis of the mediators involved in the acute pulmonary edema produced in rats by adrenaline.


The pharmacology of slow reacting substance C and of arachidonic acid.


Reversal by L-DOPA of the suppression of locomotor activity induced by inhibition of tyrosine-hydroxylase and DA-beta-hydroxylase in mice.


Life and medical care in China today.

Life and medical care in China today.


Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes.


Onset of synthesis of mitochondrial enzymes during mouse development. Synchronous activation of parenteral alleles at the gene locus for the M-form of NADP-dependent malate dehydrogenase.


(Omega -2) hydroxylation of fatty acids by a soluble system from bacillus megaterium.


On the role of glial cells in the mammalian nervous system. Uptake, excretion, and metabolism of putative neurotransmitters by cultured glial tumor cells.


Electron paramagnetic resonance-detectable electron acceptors in beef heart mitochondria. Reduced diphosphopyridine nucleotide ubiquinone reductase segment of the electron transfer system.


Abnormal microsomal cytochromes and electron transport in Morris hepatomas.


Adrenergic and antiadrenergic drugs.

Adrenergic and antiadrenergic drugs.


Cytochrome P450 and steroid 21-hydroxylation in microsomes from beef adrenal cortex.


Oral health in preschool Swedish children. 1. Three-year-old children.


Smoking and drug consumption in white, black, and oriental men and women.


The heme protein P-450 in steroid hydroxylation.


Adult population estimate of Toxorhynchites brevipalpis. An estimate of the numbers of adults of the predacious mosquito Toxorhynchites brevipalpis was made in a 1-ha biotope in Dar es Salaam, Tanzania, where the population of its larval prey Aedes aegypti was high, by means of the mark-release-recapture method. Two months after the end of the rainy season, the number of adults was estimated to be 3 500-about 6 times the number of adult A. aegypti in the biotope.


Depression of erythrocyte delta-aminolaevulinic acid dehydratase activity in alcoholics.


Interaction between hormones and cyclic AMP in regulating specific hepatic enzyme synthesis.


Patients' acceptance of physician's assistants.


A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin). Sixty-four patients with proven ulcerative colitis who had been maintained on sulphasalazine as their sole form of treatment for a minimum period of one year were entered into a controlled trial of sulphasalazine versus dummy tablets for a period of six months. All the patients admitted were not only symptom-free but also showed no evidence of inflammation on sigmoidoscopy and rectal biopsy. A patient was judged to have relapsed when there was a recurrence of colitic symptoms accompanied by sigmoidoscopic and histological evidence of inflammation. The patients who received dummy tablets had more than four times the relapse rate of those receiving sulphasalazine. The results were similar in patients who had been on maintenance treatment with sulphasalazine for less than three years before entry into the trial and in those who had been on this treatment for more than three years. It is concluded that maintenance treatment of ulcerative colitis with sulphasalazine should be continued indefinitely unless contraindicated by side effects.


Do D-glucosamine and D-galactosamine form part of specific receptor sites for competence substance on cell wall of Pneumococcus?


Action of imidazole on the cardiac inotropic, phosphorylase activating and cyclic AMP producing effects of norepinephrine and histamine.


The role of the colon in the metabolism of salicylazosulphapyridine.


Behavioral changes and aggressivity evoked by drugs in mice.


Temperature-induced phase changes in membrane lipids and their influence on metabolic regulation.


Formation of dihydrotestosterone and other 5 alpha-reduced metabolites by isolated seminiferous tubules and suspension of interstitial cells in a human testis.


Cardiac output during ritodrine treatment in premature labor.


In vitro metabolism of testosterone by whole human testis, isolated seminiferous tubules and interstitial tissue.


The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule.


Enzymes of carbohydrate metabolism in normal human sebaceous glands.


Clonal nature of the immune response to phosphorylcholine. II. Idiotypic specificity and binding characteristics of anti-phosphorylcholine antibodies.


Steroid pathways in sebaceous glands.

Steroid pathways in sebaceous glands.


Cutaneous lipogenesis. Major pathways of carbon flow and possible interrelationships between the epidermis and sebaceous glands.


Electrophysiological investigation of GABA-mediated inhibition at the hermit crab neuromuscular junction. 1. The inhibitory neuromuscular junction of the abductor muscle of the large claw of the hermit crab (Eupagurus bernhardus) was investigated using electrophysiological intracellular techniques in order to elucidate further the relative contributions of the pre- and post-synaptic mechanisms of action of GABA and of neural inhibition.2. The electrical constants of the post-synaptic membrane, calculated using the equations for a ;short cable' model, were characteristic of a poorly developed electrical excitability; the specific membrane resistance was usually < 1000 Omega cm(2) and the specific membrane capacitance was > 40 muF/cm(2).3. Stimulation of the excitatory axon to the abductor muscle of the large claw at a frequency of 20 Hz evoked highly facilitating excitatory junction potentials (e.j.p.s); stimulation of the inhibitory axon (60-220 Hz) during the excitatory train elicited inhibition which was manifest as an attenuation of the e.j.p.s.4. The addition of gamma-aminobutyric acid (GABA) to the bathing solution produced a dose-dependent reduction of e.j.p. amplitude and membrane resistance. The inhibitory effect of concentrations (5 x 10(-5) and 1 x 10(-4)M) which caused a 40-75% e.j.p. attenuation could largely be accounted for by a post-synaptic action on membrane conductance.5. Experiments with picrotoxin suggest that presynaptic inhibitory mechanisms have an important role in neurally evoked inhibition.6. Picrotoxin (1-5 x 10(-5)M) effectively blocked neural inhibition and the actions of GABA in this preparation, whereas bicuculline proved to be considerably less potent and therefore less useful as a physiological tool for studying GABA-mediated inhibition in crustacea.


Symposium on atherosclerosis.

Symposium on atherosclerosis.


Prostaglandin E2 as stimulator of haemopoietic stem cell proliferation.


Effects of cytochalasin B on uptake and release of putative transmitters by synaptosomes and on brain actomyosin-like protein.


Reaction mechanism of NAD(P)H-linked oxygenases.


Sulphur-methylene isosterism in the development of metiamide, a new histamine H2-receptor antagonist.


Emergency nursing.

Emergency nursing.


Equinatoxin, a lethal protein from Actinia equina--I. Purification and characterization.


Equinatoxin, a lethal protein from Actinia equina. II. Pathophysiological action.


Isolation of arboviruses from mosquitoes, biting midges, sandflies and vertebrates collected in Queensland, 1969 and 1970.


The epidemiology of cutaneous leishmaniasis in Ethiopia.


Proceedings: Development of filaria in mosquitoes: ultrastructure and autoradiography.


Proceedings: Effects of pharyngeal armature of mosquitoes on microfilariae of Brugia pahangi.


Arbovirus studies in Nupeko forest, a possible natural focus of yellow fever virus in Nigeria. II. Entomological investigations and viruses isolated.


Proceedings: Hydrolases of the sporogonic stage of Plasmodium berghei nigeriensis.


Letter: Biting insects and hepatitis B virus.


Characteristics and pharmacologic utility of an intraocular pressure (IOP) model in unanesthetized rabbits.


Circulatory actions of phentolamine before and after autonomic blockade.


Translocation of inducible tyrosine aminotransferase to the mitochondrial fraction. Facilitation by acute uremia and other conditions.


Permeability of mitochondria from rat brain and rat liver to GABA.


Analysis of proteins undergoing axonal transport in nigro-striatal neurons in the rat.


Effect of dibutyryl-cyclic AMP and dexamethasone on noradrenaline synthesis in isolated superior cervical ganglia.


Letter: Beta receptors and renin release.


Letter: What are physician assistants, and what do they do?


Experimental immunity to a metabolite of halothane and fluroxene: cutaneous delayed-type hypersensitivity.


Drug abuse and the emergency room physician.


The effect of ethionine on the energy-producing metabolism in the rat pancreas. II. Alterations of tissue levels of adenine nucleotides, pyridine nucleotides, and glycolytic metabolites.


Analytical study of microsomes and isolated subcellular membranes from rat liver. II. Preparation and composition of the microsomal fraction. Liver homogenates have been submitted to quantitative fractionation by differential centrifugation. Three particulate fractions: N (nuclear), ML (large granules), and P (microsomes), and a final supernate (S) have been obtained. The biochemical composition of the microsomal fraction has been established from the assay and distribution pattern of 25 enzymatic and chemical constituents. These included marker enzymes for mitochondria (cytochrome oxidase), lysosomes (acid phosphatase and N-acetyl-beta-glucosaminidase), and peroxisomes (catalase). The microsomal preparations were characterized by a moderate contamination with large cytoplasmic granules (only 6.2% of microsomal protein) and by a high yield in microsomal components. Enzymes such as glucose 6-phosphatase, nucleoside diphosphatase, esterase, glucuronyltransferase, NADPH cytochrome c reductase, aminopyrine demethylase, and galactosyltransferase were recovered in the microsomes to the extent of 70% or more. Another typical behavior was shown by 5'-nucleotidase, alkaline phosphatase, alkaline phosphodiesterase I, and cholesterol, which exhibited a "nucleomicrosomal" distribution. Other complex distributions were obtained for several constituents recovered in significant amount in the microsomes and in the ML or in the S fraction.


Analytical study of microsomes and isolated subcellular membranes from rat liver. 3. Subfractionation of the microsomal fraction by isopycnic and differential centrifugation in density gradients. Rat liver microsomal fractions have been equilibrated in various types of linear density gradients. 15 fractions were collected and assayed for 27 constituents. As a result of this analysis microsomal constituents have been classified, in the order of increasing median density, into four groups labeled a, b, c, and d. Group a includes: monoamine oxidase, galactosyltransferase, 5'-nucleotidase, alkaline phosphodiesterase I, alkaline phosphatase, and cholesterol; group b: NADH cytochrome c reductase, NADPH cytochrome c reductase, aminopyrine demethylase, cytochrome b(5), and cytochrome P 450; group c: glucose 6-phosphatase, nucleoside diphosphatase, esterase, beta-glucuronidase, and glucuronyltransferase; group d: RNA, membrane-bound ribosomes, and some enzymes probably adsorbed on ribosomes: fumarase, aldolase, and glutamine synthetase. Analysis of the microsomal fraction by differential centrifugation in density gradient has further dissociated group a into constituents which sediment more slowly (monoamine oxidase and galactosyltransferase) than those of groups b and c, and 5'-nucleotidase, alkaline phosphodiesterase I, alkaline phosphatase, and the bulk of cholesterol which sediment more rapidly (group a2). The microsomal monoamine oxidase is attributed, at least partially, to detached fragments of external mitochondrial membrane. Galactosyltransferase belongs to the Golgi complex. Group a2 constituents are related to plasma membranes. Constituents of groups b and c and RNA belong to microsomal vesicles derived from the endoplasmic reticulum. These latter exhibit a noticeable biochemical heterogeneity and represent at the most 80% of microsomal protein, the rest being accounted for by particles bearing the constituents of groups a and some contaminating mitochondria, lysosomes, and peroxisomes. Attention is called to the operational meaning of microsomal subfractions and to their cytological complexity.


Proceedings: International Union Against Cancer: brief history, organization, and program review of a non-governmental voluntary organization.


Analytical study of microsomes and isolated subcellular membranes from rat liver. I. Biochemical methods. The series introduced by this paper reports the results of a detailed analysis of the microsomal fraction from rat liver by density gradient centrifugation. The biochemical methods used throughout this work for the determination of monoamine oxidase, NADH cytochrome c reductase, NADPH cytochrome c reductase, cytochrome oxidase, catalase, aminopyrine demethylase, cytochromes b(5) and P 450, glucuronyltransferase, galactosyltransferase, esterase, alkaline and acid phosphatases, 5'-nucleotidase, glucose 6-phosphatase, alkaline phosphodiesterase I, N-acetyl-beta-glucosaminidase, beta-glucuronidase, nucleoside diphosphatase, aldolase, fumarase, glutamine synthetase, protein, phospholipid, cholesterol, and RNA are described and justified when necessary.


Proceedings: European Organization for Research on Treatment of Cancer: origin, organization, and current activities.


Transplantation of the mouse heart--a useful research model.


Treatment patterns in psychiatry: clinical and personality features of elderly hospitalized patients during milieu, single-drug and multiple-drug programs.


The training and use of physician's assistants in Indiana.


Cellularity and lipogenic enzyme activities of porcine intramuscular adipose tissue.


An electron microprobe analysis of the resistant sporangium wall of Coelomomyces psorophorae.


The influence of reducing the C7-C8 double bond of codeine to give dihydrocodeine on the relative physiological availability of the drugs in man.


Proceedings: The influence of fines on the flow and compaction properties of lactose.


Proceedings: The effects of granule porosity and strength on the porosity, air permeability and tensile strength of tablets.


Proceedings: A friability test for granules.


Proceedings: The effect of sintering on the pore structure and strength of plastic matrix tablets prepared from polyvinyl chloride.


Proceedings: Members of Miltantha section of Papaver as a source of morphinane alkaloids.


Proceedings: The alkaloidal vesicles of Papaver somniferum.


Proceedings: Phosphomonoesterases in Papaver somniferum latex.


Proceedings: The oxidation of tyrosine a precursor of morphine by polyphenolase in the 1000g organelles of Papaver somniferum.


Proceedings: Alkaloids in the bark of Zanthoxylum clava-herculis.


Proceedings: The natural occurrence of tropane alkaloid N-oxides.


Proceedings: The role of molecular diffusion in the bulk stability of o-w hydrocarbon emulsions.


Proceedings: An investigation of the properties of propranolol hydrochloride in aqueous solution.


Proceedings: Some physical properties of promethazine in aqueous solution.


Proceedings: The apparent molal volumes, Ov, of hexamethonium bromide (HexBr2) and decamethonium bromide (DecaBr2) at 25 degrees.


Proceedings: Approaches to the formulation of a long-acting intramuscular injection.


Proceedings: Application of Buslik's concept of homogeneity to pharmaceutical ointments.


Proceedings: The effect of thermodynamic activity on the percutaneous absorption of methyl nicotinate from water glycerol mixtures.


Proceedings: Comparative bioavailability of proprietary hydrophilic topical steroid preparations.


Proceedings: The effects of amphetamine, 2-aminoindane and 2-aminotetralin on the concentrations of whole brain noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the mouse.


Proceedings: An interaction between morphine and fenfluramine in mice.


Proceedings: The neuromuscular blockade caused by fractions obtained by chromatography of commercial B. multicinctus venom.


Proceedings: The effects of some bungarotoxins on skeletal muscle fibres in tissue culture.


Proceedings: The effects of beta-type bungarotoxins on the responses of the chick biventer cervicis muscle to cholinoceptor agonists.


Proceedings: The effect of dopamine-antagonists and amantadine on the acquisition of the conditioned avoidance response in rats.


Proceedings: The effect of phase-shift on the passive avoidance response in rats, and the modifying effect of chlordiazepoxide.


The effect of sintering on the pore structure and strength of plastic matrix tablets.


Proceedings: Inactivation by gamma-rays of Bacillus megaterium spores suspended in aqueous solutions of ethanol, acetone and 1,4-dioxane of widely varying concentrations.


Proceedings: The effect of sporulation temperature upon the post-germinative resistance of Bacillus subtilis.


Proceedings: Inhibitors of thymidylate synthetase as R factor curing agents.


Proceedings: A comparison of the effect of polymyxin B sulphate and phenylethanol on Pseudomonas aeruginosa.


Proceedings: Rabbit eye irritation from bactericides in soft lens soaking solutions.


Proceedings: Effect of additives on freeze-drying of a herpes virus.


Proceedings: Accelerated stability testing of freeze-dried preparations of Penicillium chrysogenum WIS54-1255.


Proceedings: Correlation of androgenic activities of the lower testosterone esters in rat, with Rm values and hydrolysis rates.


Proceedings: Dissolution rate as a parameter in structure-activity studies.


Proceedings: The influence of non-ionic surfactant type on the transport of a drug across a biological membrane.


Proceedings: Transit in free films: surface heterogeneity.


Proceedings: Some pharmacological indications of a role for taurine in the regulation of pituitary activity.


Proceedings: Studies on the central hypotensive effects of clonidine.


Proceedings: Absorption, distribution and excretion of doxapram hydrochloride in the rat.


Proceedings: The absorption, distribution, and excretion of 2-amino-4-phenylsulphonyl benzene sulphonamide (NSD 3004) in rats.


Proceedings: Interaction of phenobarbitone and ethanol studied from dose-response curves and drug concentrations in blood.


Proceedings: Uncaria species as sources of the alkaloids gambirine and the roxburghines.


Proceedings: Environment and the production of cannabinoids in Cannabis sativa.


Proceedings: Sapogenins and phytosterols of some Digitalis species.


Proceedings: The interconversion of open and closed E ring oxindole alkaloids in Mitragyna species.


Proceedings: An evaluation of tolu balsam by gas-liquid chromatography.


Proceedings: Dissolution rate and the surface area of compacted powder systems.


Proceedings: A screening procedure for Euphorbia co-carcinogenic irritants.


Proceedings: The influence of micelle-drug solubilization on dissolution rates.


Proceedings: The effect of solvent flow on the dissolution rate of a non-disintegrating solid (potassium chloride).


Proceedings: The effect of surface coatings on the dissolution rate of a non-disintegrating solid (potassium chloride).


Proceedings: Bioavailability of salicylamide from tablets.


Proceedings: The effect of formulation on the availability of sulphadiazine.


Proceedings: Cis-N-2-arylcyclohexylamines and their quaternary ammonium salts--two new series of cholinesterase inhibitors.


Proceedings: A solid dosage form with constant release.


Proceedings: Cyclohexane derivatives with muscarinic and anti-muscarinic actions.


Proceedings: Neuromuscular blocking agents: the norcoralydine methiodides.


Proceedings: Synthesis and characteristics of the enantiomers of the cyclic metabolite of methadone.


Proceedings: A comparison of stationary phases for the g.l.c. of basic drugs.


Proceedings: The spectrophotometric determination of ampicillin and cloxacillin in combined preparations.


Proceedings: Modification and application of automated analysis for morphine.


Proceedings: Molecular aggregation in aqueous bile salt-phosphatidylcholine solutions.


Proceedings: Observations on the time-dependent behaviour of monolayers of 1,2-dipalmitoyl-L-3-phosphatidylethanolamine.


Proceedings: The binding of 8-anilino-1-naphthalene sulphonate (ANS) to phosphatidylcholine and its displacement by indomethacin.


Proceedings: The transport of penicillins across non-aqueous membranes in the presence of phospholipids.


Proceedings: Studies on drug-nylon interactions.


Proceedings: The effect of mixing time on the bulk properties of magnesium stearate-sand mixtures.


Proceedings: The influence of excipient type and drug particle size upon a small-scale mixing process.


Proceedings: The use of adsorbents to prevent mottling in coloured tablets.


Proceedings: The effect of surface active-agents on the zeta potential of particles in a model suspension system.


Proceedings: Toxicity studies on some p-substituted acetanilides.


Proceedings: The influence of alcohol chain length on the structure and rheology of emulsions stabilized by cetrimide-long chain alcohols.


Proceedings: Micellar properties of aqueous solutions of n-alkylpolyoxyethylene surfactants.


Proceedings: The effect of tetracyclines on the rheological properties of bronchial mucus.


Proceedings: The effect of ageing on the rheological properties of gelatin gels.


Proceedings: The strength, hardness and elasticity of moist films of gelatin.


Proceedings: Metabolism of ephedrine on and near its basic centre.


Proceedings: The importance of hydrolysis and N-oxidation in the in vitro metabolism of N-2-benzoyloxyethylnorfenfluramine (JP992--780SE).


Proceedings: In vitro metabolic N-oxidation of the minor tobacco alkaloids, (-)methylanabasine and (-)anabasine to yield a hydroxylamine and a nitrone in lung and liver homogenates.


Proceedings: Activation and inhibition of trypsin digestion of fibrin by sodium flufenamate.


Proceedings: Protein binding by equilibrium dialysis and equilibrium ultrafiltration: a comparative evaluation.


Proceedings: An esr titration technique for the determination of accessible tyrosyl and tryptophyl residues in globular proteins.


Diffusion in sucrose solutions.

Diffusion in sucrose solutions.


The tensile strength and compression behaviour of lactose, four fatty acids, and their mixtures in relation to tableting.


The stability of aqueous solutions of phenylephrine at elevated temperatures: identification of the decomposition products.


Variation in delivery of isoprenaline from various pressurized inhalers.


The effect of particle shape and crystal habit on properties of sodium chloride.


A stable method for calculating oral drug absorption rate constants with two compartment disposition.


A method of interpreting time-response curves.


Scanning electron microscopy of nylon microcapsules.


The anomalous behaviour of some oxyclozanide polymorphs.


The influence on pharmaceutical granulation of the type and capacity of mixers.


Strain recovery of compacts on extended storage.


Stabilization of oil-in-water emulsions by alkyl sulphates: the effect of a long chain alcohol.


A moisture transfer effect in hard gelatin capsules of sodium cromoglycate.


Tyrosine aminotransferase induction in rat liver as a response to irradiation or flash burn injuries.


The effects of alpha stimulation and alpha blockade on pulmonary vascular segment resistance in canine cardiogenic shock.


Letter: Beta-blocking agents and platelet aggregation.


Physician overpopulation.

Physician overpopulation.


The effects of long term administration of psychotrophic drugs on human sleep. IV. The effects of chlorpromazine.


The effects of long term administration of psychotropic drugs on human sleep. V. The effects of chloral hydrate.


Brompheniramine and the cardio-vascular effects of norephedrine and noradrenaline.


Disodium cromoglycate (Lomudal) in the treatment of hay fever.


Radiochemical determination of the optical purity of L-amino acids.


Effect of temperature on urocanase from a psychrophile, Pseudomonas putida.


Amino acid analyses of chymotrypsin-like proteases from the sea anemone (Metridium senile).


25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties.


Clinical pharmacology in endodontics and intracanal medicaments.


Endodontic case reports.

Endodontic case reports.


Current status of the physician's assistant in Oklahoma.


Biochemical procedures as aids in diagnosis of different forms of cancer.


Comparison of two experiences using physician's assistants.


Why Beta-blockade for hypertension?

Why Beta-blockade for hypertension?


Proceedings: Mode of action of beta-adrenergic receptor blocking drugs in hypertension.


Proceedings: Combined alpha and beta-receptor blockade in the treatment of severe hypertension.


A panel discussion was held on "Present views on the management of hypertension".


Proceedings: General practitioner studies of beta-blockade in hypertension.


Proceedings: Pharmacological effects of a combination of alpha- and beta-blockers.


The occurrence of larvae of Strongylus edentatus in the testicles of stallions.


Relative value of various etiological factors in short lasting, adverse psychological reactions to cannabis smoking.


The effect of beta blockade and-or physical training in patients with angina pectoris.


Structure of medical care services in the U.S.S.R.


Education for general practice--worldwide problems.


Clinical study of dental caries and tongue thrust.


Photosensitization reactions of chlorophyll.


Measurement of Hill reactions and photoreduction.


The effects of iron-limited growth on the reduced nicotinamide-adenine dinucleotide dehydrogenase activity and the membrane proteins of Candida utilis mitochondria. 1. The mitochondrial NADH dehydrogenase (EC 1.6.99.3) of Candida utilis exhibited altered properties when the organism was grown under iron-limited conditions. No suitable acceptor was found for assay of this enzyme from iron-limited cells. 2. Mitochondrial membrane proteins from C. utilis were analysed by polyacrylamide-gel electrophoresis. Compared with glycerol-limited cells, iron limitation resulted in the loss of at least two polypeptides from the mitochondrial membrane. 3. Neither of the polypeptides affected by iron limitation was part of a cytochrome, although one of them was part of the mitochondrial NADH dehydrogenase. 4. Non-haem iron of mitochondrial membranes was released in the presence of sodium dodecyl sulphate, and electrophoresis in solutions of this detergent cannot be used directly to identify iron-sulphur proteins. Non-ionic detergents do not release non-haem iron but nor do they provide a satisfactory system for electrophoretic separation.


Studies on selenium incorporation into, and electron-transfer function of, liver microsomal fractions from normal and vitamin E-deficient rats given phenobarbitone. 1. The incorporation of (75)Se from Na(2) (75)SeO(3) into the liver endoplasmic reticulum of rats given phenobarbitone was investigated by using a zonal centrifuge technique. 2. It was found that, in rats deprived of vitamin E, or of vitamin E and selenium, phenobarbitone was without effect on the incorporation of (75)Se or on its conversion to (75)Se(2-). When vitamin E was given at the same time as the phenobarbitone and (75)Se, there was a large increase in the amount of (75)Se and (75)Se(2-) found in the smooth reticulum. It is concluded that there may be a specific vitamin E-dependent role for selenium and selenide in the smooth endoplasmic reticulum, and it is suggested, in the light of these and other observations, that the selenide may form a part of the active centre of a non-haem iron-containing protein ;X', that may function in microsomal electron transport. 3. Measurements of the contents of cytochromes P-450 and b(5) in liver microsomal fractions of rats given vitamin E-deficient, and vitamin E- and selenium-deficient diets, showed that haemoprotein biosynthesis is unimpaired in these rats and phenobarbitone treatment resulted in the expected increase in the haemoproteins. 4. When the reduction of cytochrome P-450 by NADH and NADPH was measured, no difference was found between normal and deficient animals. 5. These results are discussed in relation to current knowledge of microsomal electron transfer.


Role of mixed-function amine oxidases in N-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations. Pretreatment of hamsters with 3-methylcholanthrene (100mg/kg body wt.) 24h before death did not appreciably change the extent of N-oxide formation when hepatic microsomal preparations were incubated with NN-dimethylaniline as substrate. In contrast, the N-hydroxylation of 2-acetamidofluorene was increased severalfold in hepatic microsomal preparations from pretreated animals. Under these conditions there were no appreciable changes in cytochrome P-450 content and NADPH-cytochrome c reductase activity. On the basis of these comparative data, it is suggested that amine oxidase is not involved in N-hydroxylation of 2-acetamidofluorene.


Isoenzyme patterns in parenchymal and non-parenchymal cells isolated from regenerating and regenerated rat liver. Parenchymal and non-parenchymal cells were isolated from adult rat liver that had been fully regenerated after a 70% partial hepatectomy. The characteristics of the parenchymal cell preparations from regenerated rat liver indicated that they were a homogeneous population and comparable with parenchymal cells isolated from intact liver. The parenchymal cells from regenerated adult rat liver contain glucokinase, hexokinase, pyruvate kinase type I and aldolase B. The non-parenchymal cells contain hexokinase, pyruvate kinase type III and aldolase B. When cells were isolated at different times of the day from rats on controlled feeding schedules, variation of tyrosine aminotransferase activity and liver glycogen content were observed in the parenchymal cells in keeping with the reported diurnal oscillations found in whole liver extracts. When parenchymal cells were isolated from rats 48 and 72h after partial hepatectomy, different isoenzyme patterns were observed. These cells appeared to synthesize pyruvate kinase type III, a function that was assigned previously to non-parenchymal cells or to foetal rat liver hepatocytes.


Synthesis of 3- and 4-O-beta-D-galactopyranosyl-L-rhamnose, and of 3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-rhamnose, and their use in precipitin inhibition studies with type VII antipneumococcal serum.


The reconstitution of oxidase activity in membranes derived from a 5-aminolaevulinic acid-requiring mutant of Escherichia coli. 1. The reconstitution of oxidase activity in cell-free extracts of a mutant of Escherichia coli K12Ymel, that require 5-aminolaevulinic acid for growth on non-fermentable carbon sources, is described. 2. The reconstitution is dependent on haematin or a haem extract from a prototrophic strain of E. coli, and the product of the reaction has been identified as NADH-reducible cytochrome b. 3. The requirement for haematin cannot be replaced by four other porphyrins. Coproporphyrin III does not inhibit the haematin-dependent reconstitution, mesoporphyrin IX and protoporphyrin IX apparently compete with haematin for a binding site on the cytochrome apoprotein(s) and deuteroporphyrin IX binds to cytochrome apoprotein(s) and cannot be subsequently replaced by haematin. 4. The properties of electron-transport particles from cell-free extracts of the mutant strain, grown aerobically in the presence or absence of 5-aminolaevulinic acid, are described. In the absence of 5-aminolaevulinic acid no detectable cytochromes are produced, and oxidase activities are lowered but there is no apparent effect on the activities of the NADH dehydrogenase and d-lactate dehydrogenase. 5. The reconstitution of oxidase activity by electron-transport particles from cells grown in the absence of 5-aminolaevulinic acid requires ATP and haematin, and the product of the reaction was identified as NADH-reducible cytochrome b. 6. It is concluded that the cytochrome apoproteins are synthesized and incorporated into the cytoplasmic membrane of E. coli in the absence of haem synthesis. The subsequent reconstitution of functional cytochrome(s) requires protohaem, but the nature of the side chain on the 2 and 4 positions of the porphyrin appears to be important.


Ion transport across the erythrocyte membrane.


Hospital sponsors rural facility.

Hospital sponsors rural facility.


The regulation of glutamine metabolism in Candida utilis: studies with 15NH3 to measure in vivo rates of glutamine synthesis.


Effects of membrane depolarization on nicotinamide nucleotide fluorescence in brain slices. 1. Simultaneous measurement of tissue NAD(P)H fluorescence and respiration was used to elucidate some of the early chemical changes after depolarization of the membranes of cerebral-cortical cells. Depolarization was effected by the application of a train of short-duration voltage pulses across a slice of guinea-pig cerebral cortex. The pulses cause a biphasic change in fluorescence corresponding to an early (within 1s) oxidation and later (about 10s) reduction of nicotinamide nucleotide. The major portions of both these redox changes are unrelated to the accompanying increase in slice respiration of about 75%. 2. The early oxidation requires Ca(2+) and phosphate in the bathing medium and appears to be largely due to an early mitochondrial uptake of these ions. 3. The ensuing reduction occurs in the cytosol, as judged by its almost complete elimination in the presence of exogenous pyruvate. It becomes markedly attenuated with increasing time of incubation. This and the ability of exogenous 6-N-2'-O-dibutyryl cyclic AMP to cause a reduction in the absence of electrical pulses suggest that it results from a cyclic AMP-mediated activation of glycogenolysis. 4. Further results, obtained in the presence of exogenous pyruvate, indicate that in addition to the above effects a net transfer of NADH from the mitochondrial to cytosolic space (presumably via a shuttle mechanism) is activated by the electrical pulses. 5. The lack of any sizeable (more than 2% of basal fluorescence) fluorescence change associated with the respiratory increase caused by the pulses, and the fact that any change which may be associated with it corresponds to a small reduction of mitochondrial nicotinamide nucleotide, show that a simple state 4 --> state 3 mitochondrial transition cannot account for the increased respiration. The results suggest, rather, a co-ordinated control of respiration, at more than one site.


The regulation of glutamine metabolism in Candida utilis: the role of glutamine in the control of glutamine synthetase.


The regulation of glutamine metabolism in Candida utilis: the inactivation of glutamine synthetase.


Identification and quantitative determination of phenothiazine drugs in urine samples of psychiatric patients.


Prescribing patterns in the New York City Medicaid program.


Review lecture on the growth and form of a bacterial cell.


MMPI indices of personality change following short- and long-term hospitalization of heroin addicts.


Effectiveness of marathon group psychotherapy with hospitalized female narcotics addicts.


An abbreviated MMPI for use with college students.


Self-concept of neurotic and sociopathic criminal offenders.


Pharmacologic management of allergic diseases.


Immunologic disorders in the dog and cat.


Studies on the metabolism of ethynylestradiol in vitro and in vivo: the significance of 2-hydroxylation and the formation of polar products.


The metabolism of sympathomimetic bronchodilator drugs by the isolated perfused dog lung.


Effect of drugs and alcohol on psychomotor skills related to driving.


Physical urticaria. Its diagnosis and treatment.


Clinical and pharmacological investigations of the psychobiology of the affective disorders.


Editorial: Drug Metabolism and Disposition: the biological fate of chemicals.


Skin reactivity and antibody response following vaccination against smallpox. Revaccination between 2 and 5 years after the last vaccination induced higher complement-fixation titres than revaccination 7-63 years after the last vaccination. The highest CF titres were reached during the 3rd to the 5th week after vaccination.Fifty-two serum samples, taken 137 or more days after a successful vaccination, all showed CF titres lower than 1/2.In a group of successfully vaccinated persons with no post-vaccinal complications, 65 out of 66 had a successful ;take' after one or two subsequent vaccinations.Sera of persons receiving primary vaccination showed significantly lower CF titres than sera of revaccinated persons. Cases of post-vaccinal encephalitis showed greater antibody response than uncomplicated successfully vaccinated cases in both the primary vaccination and revaccination groups. The antibody response in revaccinated persons with post-vaccinal encephalitis was greater than that in the group of successfully revaccinated cases without encephalitis.A group of 26 naturally hyporeactive persons completely failed to ;take' even after vaccination repeated between 3 and 10 times (average 5 times per person). The frequency of seropositives in this group, and the height of their CF titres, were significantly lower than in the group of successfully vaccinated persons. These findings support the view that untreated persons who repeatedly fail to ;take' with the vaccine must not be considered immune.In vaccinated persons treated with immunoglobulin (with or without simultaneous treatment with Marboran) antibody production was apparently diminished. Treatment of patients with Marboran significantly lowers the capacity of the vaccine to ;take'.


A virological study of post-vaccinal encephalitis. In the province of Voyvodina 18 cases of post-vaccinal encephalitis have been recorded, three of which were fatal.The estimated morbidity rate was 0.6 per 10(5) after revaccination, and 3.9 per 10(5) after primary vaccination. The virological studies described, as well as other findings referred to in this report, are consistent with the possibility of an autoimmune aetiology of the post-vaccinal encephalitis cases observed.


Complications of occult pneumococcal bacteremia in children.


Sea nettle and man-o'war venoms: a chemical comparison of their venoms and studies on the pathogenesis of the sting.


Absorption, distribution, and excretion of quingestanol acetate by the rat.


Rates of synthesis and degradation of hepatic acetyl CoA carboxylase in fed, fasted, fasted-refed, and diabetic rats.


A rapid method for the mass spectrometric identification of glucuronides and other polar drug metabolites in permethylated rat bile.


Is pre-employment medical examination of value? The validity of a computerized health questionnaire.


Mammalian metabolism of terpenoids. I. Reduction and hydroxylation of camphor and related compounds.


The relationship of testicular tumours to maldescent.


The use of mass spectroscopy and 13C and 1H nuclear magnetic resonance in the characterization of 1-methyl-(2, 6-xylyloxy)ethylamine metabolites.


Examination of extinction coefficients of soluble and membrane-bound cytochromes P-450 and P-420.


Quantification of serum creatine phosphokinase isoenzyme activity.


Metabolic disposition of 18-homoestriol in the rat, dog, and man.


Hepatorenal toxicity following fluroxene anesthesia.


Clinical recognition of leprosy: some factors leading to delays in diagnosis. The case histories of eight patients in the United Kingdom admitted to hospital for the diagnosis of leprosy are examined in detail. Review of their early symptoms and signs showed that there had been delays in diagnosis, ranging from a few months to many years. Possible reasons for delay are discussed, and attention is called to the importance of nasal symptoms in the early diagnosis of lepromatous leprosy.


Editorial: Adverse reactions to beta-adrenergic blockade.


Increased tyrosine hydroxylase activity in the locus coeruleus of rat brain stem after reserpine treatment and cold stress.


Direct conversion of 17beta-estradiol-3-glucosiduronate and 17beta-estradiol-3-sulfate to their 17-keto forms by human kidney homogenates.


Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors.


Gamma-glutamyl transpeptidase of rat kidney. Some properties and kinetic constants.


DPT as an adjunct in psychotherapy of alcoholics.


A controlled evaluation of pyrovalerone in chronically fatigued volunteers.


D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida. Pseudomonas putida oxidized isoleucine to acetyl-coenzyme A (CoA) and propionyl-CoA by a pathway which involved deamination of d-isoleucine by oxidation and l-isoleucine by transamination, oxidative decarboxylation, and beta oxidation at the ethyl side chain. At least three separate inductive events were required to form all of the enzymes of the pathway: d-amino acid dehydrogenase was induced during growth in the presence of d-isoleucine; branched-chain keto dehydrogenase was induced during growth on 2-keto-3-methylvalerate and enzymes specific for isoleucine metabolism; tiglyl-CoA hydrase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase were induced by growth on isoleucine, 2-keto-3-methylvalerate, 2-methylbutyrate, or tiglate. Tiglyl-CoA hydrase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase were purified simultaneously by several enzyme concentration procedures, but were separated by isoelectric focusing. Isoelectric points, pH optima, substrate specificity, and requirements for enzyme action were determined for both enzymes. Evidence was obtained that the dehydrogenase catalyzed the oxidation of 2-methyl-3-hydroxybutyryl-CoA to 2-methylacetoacetyl-CoA. 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase catalyzed the oxidation of 3-hydroxybutyryl-CoA, but l-3-hydroxyacyl-CoA dehydrogenase from pig heart did not catalyze the oxidation of 2-methyl-3-hydroxybutyryl-CoA; therefore, they appeared to be different dehydrogenases. Furthermore, growth on tiglate resulted in the induction of tiglyl-CoA hydrase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase, but these two enzymes were not induced during growth on crotonate or 3-hydroxybutyrate.


Letter: Plasma enzymes in liver disease.


Regulation of leucine catabolism in Pseudomonas putida. The generation time of Pseudomonas putida with l-leucine was 20 h in synthetic media but only 3 h with d-leucine. Slow growth in the presence of l-leucine was partially overcome by addition of 0.1 mM amounts of either d-valine, l-valine, or 2-ketoisovalerate. The activities of five enzymes which take part in the oxidation of leucine by P. putida were measured under various conditions of growth. Four enzymes were induced by growth with dl-leucine as sole source of carbon: d-amino acid dehydrogenase, branched-chain keto acid dehydrogenase, 3-methylcrotonyl-coenzyme A carboxylase, and 3-hydroxy-3-methylglutaryl-coenzyme A lyase. The segment of the pathway required for oxidation of 3-methylcrotonate was induced by growth on isovalerate or 3-methylcrotonate without formation of the preceding enzymes. The synthesis of carboxylase and lyase appeared to have been repressed by the addition of l-glutamate or glucose to cells growing on dl-leucine as the sole carbon source. Mutants unable to grow at the expense of isovalerate had reduced levels of carboxylase and lyase, whereas the levels of three enzymes common to the catabolism of all three branched-chain amino acids and those of two isoleucine catabolic enzymes were normal.


Factors of human chronic pain: an analysis of personality and pain reaction variables. Factor analysis of pain and personality test data obtained from 119 patients with chronic pain syndromes yields seven factors: four composed of personality measures, two involving different psychophysical pain measures, and one sex-related factor. The chief factors, comprising more than 50 percent of the total variance, are "interpersonal alienation and manipulativeness," "clinical pain intensity", and "pain endurance."


B-cell alloantigens determined by the H-2 linked Ir region are associated with mixed lymphocyte culture stimulation. Cell surface antigens, controlled by genes located in the Ir region of the murine major histocompatibility complex, are shown serologically to be expressed preferentially on bone marrow-derived lymphocytes. These antigens may play a major role as stimulators in mixed lymphocyte cultures.


Increase in plasma alpha-lipoproteins in chronic alcoholics after acute abuse.


Crohn's disease of the mouth.

Crohn's disease of the mouth.


Stress-induced gastric lesions in spontaneously hypertensive rats. Involvement of autonomic neurotransmitter substances.


The popliteal node assay for graft-versus-host interaction in mice. I. Location and proliferation of donor and host cells within the popliteal node.


Serum gonadotropins in cryptorchidism. An indicator of functional testes.


A quantitative ultrastructural and biochemical analysis of the process of reinnervation of the superior cervical ganglion in the adult rat.