The essence of gonorrhoea control. IV. The promiscuous female pool.


Phenobarbital and the shoulder-hand syndrome.


Classification of immunoglobulins in the dermal-epidermal junction in lupus erythematosus.


Donovanosis.

Donovanosis.


The influence of thioridazine upon urinary gonadotropin excretion.


Congenital agammaglobulinemia: a review.


Patch test methods. II. Regional variations of patch test responses.


Diagnostic importance of punch biopsy and cytologic examination in herpes zoster and herpes simplex.


The character of cells with "altération cavitaire" (Leloir).


Report on a case of subcutaneous dissemination of Aspergillus niger, type awamori.


Investigations of dermatophyte sensitivity to griseofulvin.


Unusual cutaneous manifestations in Wegener's granulomatosis.


Dermatitis in a crisp factory.

Dermatitis in a crisp factory.


Kinetics of glycolysis after fluocinolone acetonide in psoriasis.


The essence of gonorrhoea control. I. The importance of "feed back".


Recurrence of gonorrhoea following penicillin treatment.


Etiological problems in connection with a case of Kaposi's varicelliform eruption.


Survival in males with bronchogenic carcinomas resected as asymptomatic solitary pulmonary nodules.


Coexistent chronic myelocytic leukemia, monoclonal gammopathy and multiple chromosomal abnormalities.


Problems in surgery for bronchogenic carcinoma.


Observations on the ultrastructure of the plasmalemma in oranges.


Varicella-zoster infections in pregnancy.


Rapid uptake of tritiated antigen by mouse eosinophils.


Chromatography, physical characteristics, and disulfide bonds of euglobulin plasminogen.


The dose of antigen required for the suppression of the IgM and IgG antibody response in chickens. II. Studies at the cellular level.


The mechanism of the differential staining reaction for adrenaline-and noreadrenaline-storing granules in tissues fixed in glutaraldehyde.


The rheumatic diseases; laboratory procedures and diagnosis.


Radiation therapy of lung cancer. Maine Medical Center, 1955-1965.


Dynamics of protein-bound iodine of blood plasma in thyroid diseases.


Myelopathy caused by metastatic spinal epidural neoplasms.


The inhibitory effect of mouse gamma globulin on the lysis of isologous mouse tumour cells by human serum.


Some properties of the DNA-actinomycin K complex.


Detection of anti-gamma-globulin factors in human sera by simple screening methods.


Effect of actinomycin D on alkaline phosphatase induction by estrogen in uterine epithelium of spayed mice.


Serum-protidopoyesis in neonatally thymectomized rats develops normally.


Studies on the passage of virus and antibody-protein through the human placenta. A fluorescence-microscopic observation.


Zymosan coated particles used to prepare anti-beta-1C.


Hyperthyroidism causing atrial fibrillation in a young man.


Typical and atypical cases of Pendred's syndrome in one family.


Serum protein bound iodine and the ABO blood groups.


The goitrogenic effect of naturally occurring L-5-vinyl- and L-5-phenyl-2-thio-oxazolidone in rats.


Intravenous administration of modified gamma globulin. Several studies on a patient with agammaglobulinemia.


Quantitation of immunoglobulins in cerebrospinal fluid.


The use of a wate-soluble carbodiimide as a coupling reagent in the passive hemagglutination test.


"Protein A" from S. aureus. I. Pseudo-immune reaction with human gamma-globulin.


Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth gamma-E-globulin antibody.


The interaction of antigen with leucocytes of allergic individuals.


Effects of mild eriodate oxidation on antibodies.


The sedimentation and antigenic properties of proteins in nasal and other external secretions.


Adoptive cutaneous anaphylaxis: a technique for studying antibody globulin synthesis.


Isolated thyroid-stimulating hormone (TSH) deficiency following childbirth.


Mouse immunoglobulin allotypes: detection with rabbit antiserums. An antiserum with allotypic specificity for mouse gamma(2a)-globulins was prepared in a rabbit by injection of 7S gamma(2)-globulin of C(57)BL/6 mice. The antibody reacted with an isoantigen in the 7S gamma(2)-globulins of normal serum of mouse strains belonging to the lg-1(b) allotype class (C(57)BL/6, C(57)BL/10, and SJL strains). No precipitin reaction was observed with serum from 18 other inbred mice strains representing other lg-1 allotype classes.


An appraisal of the clinical effect of three different oral contraceptive agents and their influence on transaminase activity.


Schizophrenia as an immunologic disorder. II. Effects of serum protein fractions on brain function.


The effect of osmium fixation on the histological appearance of the normal epidermal horny layers of man and the guinea-pig.


Schizophrenia as an immunologic disorder. I. Demonstration of antibrain globulins by fluorescent antibody techniques.


Cytophotometric study of acid dye binding by proteins of isolated frog liver nuclei in relation to nuclear size.


Acute pancreatitis associated with frusemide therapy.


Agranulocytosis after desipramine.

Agranulocytosis after desipramine.


Reaction after dichloralphenazone.

Reaction after dichloralphenazone.


Jaundice and oral contraceptive drugs.

Jaundice and oral contraceptive drugs.


Secretion of gastric intrinsic factor.

Secretion of gastric intrinsic factor.


Prognosis in optic neuritis related to age.


Endocrine activity in multiple sclerosis.


Effect of phenylhydrazine-induced haemolysis on the urinary excretion of iron after desferrioxamine.


Prevention of tetanus by antitoxin of bovine origin.


Low butanol-extractable-iodine levels in the serum of patients with Down's syndrome.


Intrinsic-factor antibody in the saliva of a patient with pernicious anemia.


Acute hemodynamic changes during treatment of louse-borne relapsing fever.


Skin sensitivity to flour in bakers' apprentices.


Hormones and histones?

Hormones and histones?


Hyperuricaemia, hypertension, and vascular disease.


The primary physician in a comprehensive health service. Further reflections after a visit to the United States.


A surgical wound isolator.

A surgical wound isolator.


Inhibition of ovulation in the adult estrus rabbit by vaginal deposition.


Systemic (primary) amyloidosis associated with an IgM (beta-2M) paraproteinaemia. Biochemical, histochemical and immunohistochemical investigations.


Heterogeneity of anti-antibodies in individual human sera.


The immune response to vaccination with inactivated poliovirus vaccine in Sweden.


An improved procedure for the determination of serum protein-bound iodine by alkaline incineration.


Staining for nerve fiber and cholinesterase activity in fresh frozen sections.


An improved stain for fresh, mineralized bone sections. Useful in the diagnosis of certain metabolic diseases of the bone.


LSD and the dying patient.

LSD and the dying patient.


Electrophoretic analysis of serum proteins, glucoproteins and lipoproteins in acute infectious diseases in infants and children.


Innervation of human finger tendons as determined by histochemical techniques.


Recovery of the long-acting thyroid stimulator from serum of patients with thyrotoxicosis by concentration of immunoglobulin G.


Pancreatic catabolism of albumin and gamma-globulin.


Atrial fibrillation: anticoagulation and quinidinization.


Comparison of the behaviour of IgG and IgM anti-Forssman antibodies in agglutination, haemolysis and cytolysis.


Neuropathic fractures and joint injuries. Pathogenesis and rationale of prevention and treatment.


Canine scabies in dogs and in humans.

Canine scabies in dogs and in humans.


Fluorescent treponemal-antibody absorption tests. Studies of false-positive reactions to tests for syphilis.


New psychiatric unit at Bridgewater Hospital, Manchester.


Nasal drops and sprays.

Nasal drops and sprays.


How drugs act. 5. Drugs and the thyroid gland.


Schizophrenia as an immunologic disorder. 3. Effects of antimonkey and antihuman brain antibody on brain function.


Caries-like lesions in rat calculus.

Caries-like lesions in rat calculus.


The posterior thalamic region in man.

The posterior thalamic region in man.


The pathogenesis of postobstructive diuresis.


An immunoelectrophoretic study of the soluble antigens of the human prostate.


Radioactive phosphorus in the treatment of metastasis to bone from carcinoma of the prostate.


The blind-loop syndrome.

The blind-loop syndrome.


John Josias Conybeare.

John Josias Conybeare.


Propranolol and hypoglycaemia.

Propranolol and hypoglycaemia.


An immunological study of categories of gastritis.


The organization of the ventral anterior nucleus of the thalamus. A Golgi study.


Glucose tolerance in hypertensive patients on long-term diuretic therapy.


Relation of residual placental blood-volume to onset of respiration and the respiratory-distress syndrome in infants of diabetic and non-diabetic mothers.


Acid secretion in symptomatic sliding hiatus hernia.


Renal failure in malaria.

Renal failure in malaria.


Agglutination of tanned sheep erythrocytes by serum from Nigerian adults and children.


A pneumothorax valve.

A pneumothorax valve.


Effect of interstitial pressure on pulmonary blood-flow.


Lymphocyte stimulation and chronic liver disease.


Cushing's syndrome: use of lysine vasopressin to distinguish overproduction of corticotrophin by pituitary from other causes of adrenal cortical hyperfunction.


The mortality of appendicitis.

The mortality of appendicitis.


A parting gift.

A parting gift.


Barbiturate poisoning.

Barbiturate poisoning.


Preventing misuse of L.S.D.

Preventing misuse of L.S.D.


Veratrum and myasthenia gravis.

Veratrum and myasthenia gravis.


Local government.

Local government.


Fluorides and osteoporosis.

Fluorides and osteoporosis.


Diabetic neuropathy.

Diabetic neuropathy.


Outpatient treatment of heroin addiction.


Some aspects of current therapy in acute leukemia.


Vinca alkaloids and salivary-gland pain.


Prevalence and pathological changes of ischaemic heart-disease in a hard-water and in a soft-water area.


Parietal-cell antibodies in patients with duodenal ulcer and gastric cancer.


Serum protein and cholinesterase changes in association with contraceptive pills.


Tryptophan metabolism in carcinoma of the breast.


Cellular metachromasia, a genetic marker for studying the mucopolysaccharidoses.


Role of carriers in the intrafamilial spread of cholera.


Bacteriological findings in acute otitis media.


Active renal water excretion.

Active renal water excretion.


An immunosupressive site of action of heterologous antilymphocyte serum.


Central and peripheral effects of anti-lymphocyte sera.


Relation between haemagglutination by immunoglobulin-A preparations and reaginic activity.


R-factor-mediated resistance to new aminoglycoside antibiotics.


Haemochromatosis and hepatic xanthine oxidase.


Human growth hormone and insulin.

Human growth hormone and insulin.


Endotracheal intubation or tracheostomy?


Action needed on epilepsy.

Action needed on epilepsy.


Rubella vaccines.

Rubella vaccines.


The 1967 outbreak of influenza B in the U.S.S. R.


Lead poisoning from drinking soft water.


Osmometry.

Osmometry.


The rationale of oxygen therapy.

The rationale of oxygen therapy.


Vulnerability of the organ of Corti in poisoning.


The histochemistry of mucins in certain primate salivary glands.


Further observations on the cutaneous branches of the dorsal primary rami of the spinal nerves.


Serum and bile lipids in altered thyroid function.


Evaluation of palliative operations for carcinoma of the pancreas.


Rupture of small ducts and acini in the pancreas of the rat and guinea pig following major duct obstruction.


Plutonium inhalation studies. VII. Bronchiolo-alveolar carcinomas of the canine lung following plutonium particle inhalation.


Histamine release from leukocytes of hypersensitive individuals. II. Reduced sensitivity of leukocytes after injection therapy.


A factor in pollen which enhances vascular permeability.


Studies on the placental transfer of skin-sensitizing antibody, specific binding of a ragweed fraction, and immunoglobulins.


Early secretory activity in the hypothalamic nuclei and neurohypophysis in the rat; determined by selective staining.


Urine screening techniques employed in the detection of users of narcotics and their correlation with the nalorphine test.


The anticoagulant response to bishydroxycoumarin. I. The role of individual variation.


The cellular localisation of growth hormone in the human foetal adenohypophysis.


The anticoagulant response to bishydroxycoumarin. II. The effect of D-thyroxine, clofibrate, and norethandrolone.


Antigen-induced morphological changes in germ-free mice.


Separation of 2 different substrates for plasma kinin-forming enzymes.


Influence of cold on thyroid uptake of iodine-131 and circulating iodine compounds.


Application of systems concepts to instruction.


Synthesizing language arts skills with the overhead projector.


A multi-faceted approach to teaching.

A multi-faceted approach to teaching.


A multi-media approach in the classroom for the deaf.


Effect of sequential mestranol-chlormadinone on sebum production.


Fibrillar structures ("cell web") in the cells of human adenocarcinomas.


Low radioiodine uptake and high serum PBI levels from hemorrhage into thyroid adenoma.


The surface reactions associated with fertilization of the sea urchin egg as studied by immunoelectron microscopy.


Hemangiopericytoma. Report of a case.

Hemangiopericytoma. Report of a case.


Osseous healing in dog mandibles with and without decortication.


A cytochemical examination of the spermatozoon of the domestic fowl.


Cell renewal in the oral mucosa and skin of the rat. II. DNA conservation and reutilization during the renewal cycle in vivo and in tissue explants.


Post ovulatory development of ovarian follicles in the domestic fowl.


The relative susceptibility of sheep, goats and mice to two types of the goat scrapie agent.


Inhibition of ovulation by estrogens.

Inhibition of ovulation by estrogens.


The presence of phytanic acid in normal human and animal plasma.


The existence of an alternative pathway for the degradation of branch-chained fatty acids, and its failure in heredopathia atactica polyneuritiformis (Refsum's disease).


Passive immunization with gamma globulin.


Immunoglobulin levels in cord-blood serum of negroes and Caucasians.


The clinical significance of the immunoglobulins.


The amino-terminal amino acid sequences of rabbit immunoglobulin light chains.


Imitation, modeling, and cross-cultural training. AMRL-TR-66-88.


Contact allergy to wool-fat ("lanolin"). Its incidence in a dermatological in-patient department.


An electron microscopic study of the keratinization process in lichen ruber lesions.


The pathogenesis of eczematous sensitization.


The role of keratohyalin material in the keratinization process and its importance for the barrier function.


Metabolic evaluation of the crural blood flow during standing and during sitting leg exercise in patients with congenital absence of venous valves in the legs.


Erythema chronicum migrans with multiple lesions.


Alopecia mucinosa and hypopituitarism.

Alopecia mucinosa and hypopituitarism.


Kaposi's sarcoma associated with Hodgkin's disease.


Urinary hydroxyproline in various diseases.


Fluocinolone-plastic treatment and traditional treatment in severe psoriasis. A comparative study.


The use of desoxycorticosterone acetate (DOCA) in the management of pemphigus.


The demonstration of N. gonorrhoeae with the aid of fluorescent antibodies. 5. A comparison of different techniques--absorption, one-step inhibition, and counterstaining--for elimination of cross reactions.


The demonstration of N. gonorrhoeae with the aid of fluorescent antibodies. 6. A comparison of conventional methods and fluorescent antibody (FA) techniques with counterstaining for the demonstration of N. gonorrhoeae.


Patch test methods. I. A comparative study of six different types of patch tests.


Sensitization to cobalt and nickel in cement eczema.


Occupational quinidine contact dermatitis, a concept apparently not yet described.


Bacterial allergy in the skin diseases. II. Delayed allergy to streptococci in some skin diseases.


Biologic false positive seroreactions for syphilis.


Problems in diagnosis, treatment and control of gonorrheal infections. I. A comparison of direct microscopy and culture.


Treatment of non-gonococcal urethritis with tetracycline-L-methylene lysine.


Transient kryoglobulinaemia.

Transient kryoglobulinaemia.


Comparison of various culture media for dermatophytes.


Why Acarus scabiei avoids the face.

Why Acarus scabiei avoids the face.


Cellular changes in the psoriatic epidermis. II. The submicroscopic organization in psoriatic lesions of different age.


A method for studying percutaneous toxicity of metal compounds in the guinea pig.


Autologous skin grafting in psoriasis. Observations in the first postoperative weeks.


The question of congenital keratoses.

The question of congenital keratoses.


Use of polarising microscopy in the study of hair penetration by Trichophyton mentagrophytes.


Studies of the mechanism of ultra-violet erythema formation. The role of histamine and histidine.


Subcorneal pustular dermatosis. An immunoelectrophoretic study.


Influence of polymyxin B and histamine on the cellular exudate in "skin windows".


Bound hexose of the serum in scleroderma.


The effect of chloroquine on glucose metabolism in erythrocytes of patients with chronic lupus erythematosus.


The pathogenesis of the so-called ulcus vulvae acutum.


Problems in diagnosis, treatment and control of gonorrheal infections. II. Routine sensitivity tests with the plate dilution and disc methods.


Problems in diagnosis, treatment and control of gonorrheal infections. 3. The concentration of penicillin in the blood of men and women, respectively, with different doses and makes of penicillin.


Problems in diagnosis, treatment and control of gonorrheal infections. IV. The correlation between the dose of penicillin, concentration in blood, IC-50-values of gonococci and results of treatment.


Effects of thyrotrophic hormone on thyroid cells in filter-well culture.


Pyridine nucleotides in the thyroid gland. VII. Effect of thyroid stimulating hormone on ATP concentration in dog thyroid slices.


Histamine release by passive sensitization with murine neoplastic mast cells in vitro.


Serum immunoglobulin levels in human malaria and their relationship to antibody production.


The effect of active and inactive rheumatoid factors on tolerance to human gamma-globulin in Swiss mice.


Immunoglobulin isoantigens (allotypes) in the mouse. 3. Detection of allotypic antigens with heterologous antisera.


PCA and RPCA in guinea pigs with rabbit and guinea pig antibodies and different antigens.


A histochemical study of the development of alkaline phosphatase in the testicle and epididymis of young bovine males.


Electroencephalographic changes during long term treatment with oral contraceptives.


The sequential development of lesions in spontaneous Aleutian disease of mink.


Dysimmunoglobulinemia in the absence of clinical features of multiple myeloma and macroglobulinemia.


Study of mesenteric lymph nodes in neonatally thymectomized rats with regard to cell types and gamma globulin content of cells.


Psychotic episodes associated with the use of common proprietary decongestants.


Pancreaticoduodenal cancer.

Pancreaticoduodenal cancer.


Treatment of carcinoma of the esophagus.


Refsum's disease--a recently characterized lipidosis involving the nervous system. Combined clinical staff conference at the National Institutes of Health.


Anticomplementary activity of sera from patients with connective tissue disease and normal subjects.


Endergonic reduction of mitochondrial diphosphopyridine nucleotide by sarcosine.


Acceleration of wound healing in man with zinc sulphate given by mouth.


Urinary excretion of free noradrenaline and adrenaline following acute myocardial infarction.


A critical evaluation of the trisodium-edetate test for hypo-parathyroidism after thyroidectomy.


Treatment of urinary schistosomiasis. Practice and theory.


Assessment of body-iron stores in cirrhosis and haemochromatosis with the differential ferrioxamine test.


Bacillus cereus bacteraemia. A complication of intermittent haemodialysis.


Glucose-6-phosphate-dehydrogenase deficiency, sickling, and malaria in African children in South Western Nigeria.


Isolation of diphtheroid organisms from rheumatoid synovial membrane and fluid.


Psychiatric aspects of cerebrovascular disease.


Poverty and the welfare state.

Poverty and the welfare state.


Notes towards the definition of education. A personal account of the Plowden Committee.


Trials and tribulations.

Trials and tribulations.


Subnormality and unsoundness of mind.

Subnormality and unsoundness of mind.


Propranolol and hypoglycemia.

Propranolol and hypoglycemia.


Denis John Wolko Browne.

Denis John Wolko Browne.


Possibility of a new infective aetiological agent in congestive cardiomyopathy.


The effect of cryoprecipitate concentrate in patients with classical haemophilia.


Isoenzymes of alkaline phosphatase in patients operated upon for peptic ulcer.


Bassen-Kornzweig and Refsum's syndromes. Some comments on their recognition among the N.Z. population.


Anticoagulant therapy of cerebral infarction: report of a national cooperative study.


A long term study of cerebral vascular disease.


Evaluation of anticoagulant therapy in focal ischemic cerebrovascular disease: further observations.


Prostatectomy in the community hospital.


Palliative treatment of Ewing's sarcoma.


The immunoelectrophoretic gamma-A globulin in malabsorption.


Nerve-muscle relations in the salamander: possible relevance to nerve regeneration and muscle specificity.


A new method for preparing staining solutions for bacteriological examinations.


Dentine caries.

Dentine caries.


Inhibition of the anti-globulin reaction by nonspecifically cell-bound human gamma-G-immunoglobulin.


Differences in the structure and variability of spray-like nerve endings in the joints of some mammals.


The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation.


Action of nitrous acid on recombination in E. coli.


The effect of mercuric ions on growth and respiration of two coagulase-positive Staphylococcus aureus strains.


Inhibition of Brucella-phage adsorption by Brucella endotoxins.


Hemagglutinating properties of Miyagawanella strains.


Studies on the relationships of somatic antigens among different groups of Rhizobium.


The effect of ion exchange resins on CO2 production in anaerobic respiration of yeasts.


The biosynthesis of vitamins of the B12 group in mixed cultures of bacteria.


Semi-continuous corrinoid biosynthesis by Propionibacterium petersonii.


The effect of herbicides on Rhizobium. I. Susceptibility of Rhizobium to herbicides.


Recovery of infectious virus from brain tissue of rats treated with antirabic vaccine of Semple type.


Serum uric acid values in various states of thyroid function.


Autoradiography of exfoliated epithelial cells in the study of malignant bladder mucosa. A preliminary report.


Myocardial ischaemia in infancy and childhood. Examination of 135 consecutive necropsy specimens has shown that ischaemic myocardial injury is not uncommon in infancy and childhood. The extent of the myocardial change has been assessed by a technique of staining with acid fuchsin, first described by Selye (1958). The significance of the findings is discussed.


Determination of serum thyroxine using a resin sponge technique. A method is described for the determination of serum thyroxine using ion-exchange resin sponges. The principle is based on the use of protein-binding sites and part of the technique is similar to the Triomet resin uptake test. An isotope extraction recovery procedure is incorporated in the method. Studies of factors influencing the analysis are reported and the results of tests of accuracy, precision, and specificity are presented. Serum thyroxine iodine values are compared with protein-bound iodine estimations. The values found in health and disease are similar to the results of previous workers. The specificity of the analysis represents a considerable advantage over protein-bound iodine determinations since no interference is caused by iodides, iodine-containing contrast media, mercurial diuretics, mono-iodotyrosine, di-iodotyrosine, di-iodothyronine, and also tri-iodothyronine in physiological amounts. Therapy with diphenylhydantoin and tri-iodothyronine will tend to depress protein-bound iodine levels and thyroxine values are similarly influenced.


Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat. The antigen-induced release of SRS-A and histamine was studied in the guinea pig and rat using whole and fractionated antiserum preparations. Guinea pig 7Sgamma(1)-antibody sensitized sliced guinea pig lung tissue for antigen-induced release of both SRS-A and histamine; neither substance was released from lung tissue prepared with 7Sgamma(1)-antibody. Rats injected intraperitoneally with hyperimmune rabbit or rat antiserum released only SRS-A in significant amounts when challenged with antigen by the same route. A definite time interval between the injection of antiserum and challenge with antigen was required for optimal release of SRS-A. Fractionation of rat antiserum demonstrated that the immunoglobulin responsible for most of the SRS-A release from rat peritoneal tissue was a gammaG-antibody or fraction thereof. Acting in this capacity, the gammaG-antibody or its subfraction may be considered a second type of homocytotropic antibody. Fractions of rat antisera containing the first type of homocytotropic antibody, i.e. antibody mediating release of histamine and serotonin, prepared peritoneal tissues for the release of large amounts of these pharmacological agents and only small amounts of SRS-A. Two different mechanisms for the production of PCA lesions in the rat were considered. One of these involves the antigen-induced release of histamine and serotonin from mast cells sensitized by homocytotropic antibody. This reaction has an optimal latent period of 24-72 hr. The second mechanism involves the local combination of antigen with "hyperimmune" heterologous or homologous antisera. This reaction can be elicited after a latent period of 4 but not 24 hr; host complement and leukocyte lysosomal enzymes, as well as SRS-A, may be involved.


Recovery of antibody activity from inactive hybrids of H and L chains. Hybrid IgG molecules were prepared from the heavy and light chains of specifically purified antibody against two different haptens. One hybrid consisted of the H chains from the anti-p-azobenzoate antibody from one rabbit and L chains from the anti-p-azobenzenearsonate antibody from the second rabbit, and the second hybrid consisted of the opposite combination, light chains from the first rabbit and heavy chains from the second. The two hybrids were mixed at pH 8 and were found to be so stable in the mixture that even after 2 wk at 5 degrees C there was still only low hapten-binding activity toward p-iodobenzoate and p-iodobenzenearsonate. However, exposure of the mixture of hybrids to 1 M propionic acid followed by buffer at pH 8 resulted in recovery of binding activity for p-iodobenzoate and p-iodobenzenearsonate. Thus no exchange occurred between the light and heavy chains of the hybrids in the buffer, but exchange did occur on exposure to propionic acid, and this exchange favored a preferential combination among the chains in such a manner that effective antibody sites resulted.


Studies of the Vi (gamma-2c) subgroup of gamma-globulin. A relationship between concentration and genetic type among normal individuals. Further delineation of the antigens characteristic of the Vi or gamma(2c) subgroup of gamma-globulin was carried out utilizing a number of rabbit and primate antisera. Two genetic antigens characteristic of this subgroup, Gm(b) and Gm(g), were also detected by precipitation techniques with certain of the antisera. These were clearly differentiated from antigens common to all proteins of this subgroup. The concentration, of Vi protein in normal and pathological sera from several population groups was measured quantitatively utilizing a variety of immunological procedures. All sera studied showed measurable levels. The mean value for Caucasian sera was 1.06 mg/ml, representing approximately 8% of gammaG-globulin. This agreed closely with a figure of 8.4% for the incidence of myeloma proteins of the Vi subgroup among all gammaG-myeloma proteins in Caucasians. A relationship was found between the Vi subgroup concentration and the specific genetic type of a given individual. Measurements of the Gm(b) genetic determinants, which are found solely in Vi-type proteins, brought forward this relationship. Gm(b+) individuals showed higher concentrations of Vi-type gamma-globulin than those who were Gm(b-), and this difference was statistically significant for both the homozygous and heterozygous states. It appeared that the structural genes for Gm(b+) polypeptide chains showed a greater synthetic capacity than those for Gm(b-) types. The possible significance of such effects in governing the relative composition of the antibody population in a given individual is discussed.


Gamma globulin and antibody formation in vitro. VII. Effect of x-irradiation on the secondary antibody response in vitro. The present studies have shown that the influence of X-irradiation on the secondary antibody response in vitro is remarkably similar to its effect on the primary response in vivo. When sensitized tissue was first irradiated and then reexposed to antigen, the duration of the interval between irradiation and antigen addition determined the degree of inhibition of the secondary response obtained. A delay of 12 hr resulted in stronger inhibition than a delay of 6 hr, and an interval of 24 hr before reexposure to antigen caused complete suppression of antibody production to diphtheria toxoid and almost complete suppression when sheep RBC were used as the antigen. Induction of the secondary response in rabbit lymph node tissue in vitro followed by exposure to X-irradiation, revealed that immediate exposure to irradiation after antigen produced stronger inhibition of the subsequent response than irradiation on days 2-3. Irradiation on day 6 had no detectable effect. The effectiveness of the early radiation is probably due to prevention of the proliferation of the antibody-forming cells. BUDR was found to be effective at similar time periods as X-irradiation, whereas colchicine could still stop antibody formation when added late during the secondary response in vitro. It was noted that lymph nodes from some BSA-sensitized rabbits as late as 18 months after sensitization gave a response indistinguishable from a typical secondary response, even when not reexposed to antigen.


Nuclear fluorescence employing antinucleoside immunoglobulins. Fluoresceinated antinucleoside globulins were shown to react with the nuclei of L cells. The pattern of nuclear fluorescence was similar to the distribution of nuclear DNA. This reaction was shown to be specific by the following control experiments: 1. Absorption of the specific antibody from an antiadenosine globulin eliminated all fluorescence. 2. Treatment of the cells with nonfluorescent antiadenosine globulin, followed by staining with the fluorescent antiadenosine eliminated almost all of the fluorescence of the nucleus. 3. Treatment of the cells with DNase destroyed the ability of the nucleus to react with antiuridine fluorescent antibodies. 4. Fluoresceinated anti-BSA did not produce nuclear fluorescence. Nuclear fluorescence occurred only in cells harvested during the period of maximum DNA synthesis as measured by the uptake of thymidine. This correlates with the previously demonstrated specificity of the antibodies for denatured DNA.


Studies on rabbit lymphocytes in vitro. VI. The induction of blast transformation with sheep antisera to rabbit IgA and IgM. Sheep antisera specific for the three major immunoglobulin groups of the rabbit, i.e. IgG (gamma-chain), IgA (alpha-chain), and IgM (micro-chain), are each able to induce blast transformation of the peripheral lymphocytes of the rabbit when added to in vitro cultures. The per cent of lymphocytes transformed with each antiserum indicate that one-fourth of the peripheral lymphocytes carry or have the capacity to synthesize molecules of all three of the major immunoglobulin groups, and that the remaining three-fourths carry or have the capacity to synthesize only two (IgG and IgM). The data do not permit direct conclusions concerning the ability of a single cell to produce molecules belonging to more than one immunoglobulin group at the same time, or the ability of a given cell to make a transition from the synthesis of molecules of one immunoglobulin group to those of another group.


The roentgen diagnosis of Whipple's disease (intestinal lipodystrophy), with emphasis on improvement following antibiotic therapy.


Specificity of the antibodies produced by single cells following immunization with antigens bearing two types of antigenic determinants. A combination of double immunofluorescent technique and radioautographic localization of radioactive antigens was used to investigate the question whether single antibody-producing cells can make antibodies of more than one specificity after immunization with antigens bearing more than one determinant. When guinea pig gamma(2)-globulins, containing the F(ab')(2) and Fc determinants, were used to immunize rabbits, a small percentage of cells (3.7%) were stained with both the anti-F(ab')(2) and anti-Fc reagents. These results were shown to be due to the lack of absolute specificity of the detecting antigen and antibody reagents which can be obtained for use in this system. However, when immunological systems such as hapten-protein conjugates were used, and where completely specific antigen and antibody reagents could be prepared, the results were unequivocal. The individual lymph node cells from rabbits or guinea pigs immunized with hapten-protein conjugates produced antibodies against the hapten or antibodies against the antigenic determinants of the carrier molecule, never antibodies against both specificities.


Metastatic carcinoma to the mesentery and gut.


Forms of insulin-like activity at different sites of the circulation in dogs.


Alterations in the antigenic constitution of renal glomerular capillaries accompanying the histological maturation of renal glomeruli in the rat.


Separating fact from fiction in auto smog control.


Airborne carcinogens and allied compounds.


Antinuclear factor in rheumatoid arthritis and related diseases.


Minimizing pollution from car exhaust gases.


Fluctuation of the anterior hypophyseal cell numbers of the female rat.


The vascular system in the rat upper incisor and its development.


Autoimmune reactions in rats with Plasmodium berghei infection.


Identity of trypanosome growth factors in serum. II. Active globulin components.


Electron microscope observations on the cuticle and submicroscopic binding of antibody in Ascaris suum larvae.


Prevention of Rh isoimmunization. Progress report of the clinical trial in mothers.


Tetracycline and thyroid function.

Tetracycline and thyroid function.


Panniculitis, vasculitis, and a positive lupus erythematosus cell test.


Radiation-induced thyroid dysfunction in the dog.


Posttransfusion hepatitis and its possible prophylaxis with gamma globulin.


The measurement and significance of the urinary flow rate.


Cadaveric transplants.

Cadaveric transplants.


A.S.D.C. offers new slide/lecture in color for young children.


Acriflavine-induced immunological paralysis: the effect of varying antigen doses.


Dental office audio-visual patient education.


The fate of macroaggregated albumin used in lung scanning.


Techniques used in the construction of cold cure acrylic skulls and sections of skulls.


Inhibition of RNA synthesis in HeLa and L cells by Mengovirus.


Immunological evidence for the appearance of a new DNA-polymerase in cells infected with vaccinia virus.


Thyroid hormone metabolism in the pregnant syrian hamster (Mesocricetus auratus).


Abnormal regulation of thyroid function in patients with chronic Chaga's disease.


Perfusion-fixation of the brain with chrome-osmium solutions for the rapid Golgi method.


Genetics of juvenile diabetes mellitus.

Genetics of juvenile diabetes mellitus.


Results of treatment of breast cancer at Aberdeen Royal Infirmary 1940-55.


A study on the ground substance of arteries, veins and grafted veins in dogs.


Electron microscopic study of the rodent "picodnavirus" X14.


Further observations on renal transplants in man from cadaveric donors.


Interaction of Vi antigen with proteins. Whiteside, Roberta E. (Boston University School of Medicine, Boston, Mass.), and Edgar E. Baker. Interaction of Vi antigen with proteins. J. Bacteriol. 92:1597-1603. 1966.-Purified Vi antigen (Vi) mixed in equal amounts with bovine serum albumin (BSA) or human gamma globulin (HGG) at pH values above 4.7 formed a complex which was not precipitated by trichloroacetic acid or tungstic acid. At pH values below 4.7, the interaction between Vi and either BSA or HGG produced insoluble complexes except when excess Vi antigen was present. When sufficient Vi was present at the lower pH values, the soluble complex was not precipitated by trichloroacetic acid. Other acid polysaccharides tested did not form trichloroacetic acid-soluble complexes with BSA. When subjected to immunoelectrophoresis, the Vi-BSA complex migrated in agar at a rate different from that of either BSA or Vi alone. The complex reacted with both Vi and BSA antiserum. The addition of either BSA or Vi antiserum to a Vi-BSA complex resulted in dissociation of the complex and precipitation of either Vi or BSA, depending upon the antiserum used. Vi antigen mixed with purified O antigen from Salmonella typhosa formed a complex which migrated in agar at a rate different from that of either component alone when subjected to immunoelectrophoresis.


Persistent infection of cells in culture by measles virus. I. Development and characteristics of HeLa sublines persistently infected with complete virus. Rustigian, Robert (Tufts University School of Medicine, Boston, Mass.). Persistent infection of cells in culture by measles virus. I. Development and characteristics of HeLa sublines persistently infected with complete virus. J. Bacteriol. 92:1792-1804. 1966.-After the development of marked cytopathic effects in HeLa cultures infected with the Edmonston strain of measles virus, renewed cell growth occurred, and HeLa sublines persistently infected with measles virus were obtained. Persistent infection has occurred in a large fraction of the cells of infected clonal lines for more than 300 to 500 cell generations during a period of 6 years. One mechanism by means of which infection was maintained in the clonal lines is transmission of virus or viral subunits from cell to cell at division. Continued subculture of the persistently infected populations resulted in the virtual disappearance of cytopathic effects, a marked decrease in the amount of extracellular virus, and alterations in the cytopathogenicity of virus recovered from persistently infected populations. The intracellular virus-host cell events in late passages of the infected clonal lines appeared to be similar to those in cells of primary infected cultures at early stages of infection, as judged by the pattern of viral immunofluorescence and the very low incidence of cells with intranuclear inclusion bodies. Cultures of the persistently infected clonal lines were highly resistant to super infection by parent Edmonston virus. Cultures of one of these clonal lines were just as susceptible as normal HeLa cultures to vaccinia, herpes simplex, and polio type 2 viruses, and a simian agent, with a possible low degree of resistance to the simian agent.


The fluid mechanics of the control of reflux.


The jejunum after kwashiorkor.

The jejunum after kwashiorkor.


The cardia in swallowing, eructation, and vomiting.


Encephalopathy and fatty degeneration of the viscera. Acid-base observations.


Acute pyelonephritis. Incidence of reinfection in 100 patients.


Jaundice and oral contraceptive drugs.

Jaundice and oral contraceptive drugs.


Inheritance of alcoholism. Its association with colour-blindness.


Small-bowel changes in dermatitis herpetiformis.


Chronic pyelonephritis or glomerulonephritis?


Treatment of the fetus with Rhesus disease.


The control of venereal disease.

The control of venereal disease.


Corneal lymphatics and grafts.

Corneal lymphatics and grafts.


Xga.

Xga.


The pre-discharge ward.

The pre-discharge ward.


Infectious drug resistance in Escherichia coli isolated from healthy farm animals.


Public baths revisited.

Public baths revisited.


Training the specialist surgeon.

Training the specialist surgeon.


Psyche submerged.

Psyche submerged.


Management of the patient with inoperable bronchogenic carcinoma.


Immune studies in candidiasis. 3. Precipitating antibodies in systemic candidiasis.


Passively-acquired immunity in experimental cryptococcosis.


Synthesis of donor type gamma-G-globulin following thymus transplantation in hypo-gamma-globulinaemia with severe lymphocytopenia.


Karyometric investigations of the erythroblastic system. Normal values.


Differential Mantoux testing in the diagnosis of atypical mycobacterial infection in children.


Effect of thyrocalcitonin on bone.

Effect of thyrocalcitonin on bone.


Reduction of gastric iron-binding protein in haemochromatosis. A previously unrecognised metabolic defect.


Resistance of insulin to insulinase. A genetic discriminant in diabetes mellitus.


Propranolol in acute myocardial infarction. A multicentre trial.


Potassium, glucose, and insulin in treatment of heart block after myocardial infarction.


Changes in pulmonary function 6-12 months after recovery from myocardial infarction.


Prolapse of the umbilical cord.

Prolapse of the umbilical cord.


Correction of pulmonary atresia with a homograft aortic valve.


The long-term prognosis of generalized miliary tuberculosis in children.


Renal disease and rheumatoid arthritis.

Renal disease and rheumatoid arthritis.


Isoniazid: how much a carcinogen?

Isoniazid: how much a carcinogen?


Uterine cancer.

Uterine cancer.


Calcifications in human cartilage.

Calcifications in human cartilage.


Carcinoma of the nasopharynx.

Carcinoma of the nasopharynx.


Stones in a hot climate.

Stones in a hot climate.


Medical staffing in the National Health Service in England and Wales.


Mast cells and cancer in the skin of mice.


Old people and their relatives.

Old people and their relatives.


Functions of medical boards.

Functions of medical boards.


Thomas Arthur Munro.

Thomas Arthur Munro.


Glutaraldehyde fixation of routine surgical eye tissue.


Studies on the inhibition of actinomycin biosynthesis by D-valine.


Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.


Evidence for anti-Gm(a) antibody in gamma A immunoglobulins.


Mechanism of action of TSH studied by organ culture of fetal rat thyroid gland.


Fluorescent antibody studies with Nocardia asteroides. I. Preliminary attempts in removing cross-reacting factors.


Biochemical findings in long-term oral contraceptive usage. I. Liver function studies.


The amount of gammaglobulin on the surface of leukocytes taken from diabetics and normal subjects.


Isolation of antibodies by gel-filtration.


Allergic type skin reactions in animals with alloxan diabetes.


Endometrial enzyme histochemistry in oral contraceptive therapy.


Continuous progestogen contraception: a dose relationship study with chlormadinone acetate.


The orienting reflex during waking and sleeping.


Discriminating among states of consciousness by EEG measurements. A study of four subjects.


The effect of variations in total sleep time on the occurrence of rapid eye movement sleep in cats.


Physiological correlates of steady potential shifts during sleep and wakefulness. I. Sensitivity of the steady potential to alterations in carbon dioxide.


Physiological correlates of steady potential shifts during sleep and wakefulness. II. Brain temperature, blood pressure, and potential changes across the ependyma.


Neurophysiological evidence for a differential organization of the mesencephalic reticular formation.


Modification of sensory cortical evoked potentials by hippocampal stimulation.


Amplitude measurement of the sleep electroencephalogram.


Depth EEG studies in a patient with fourteen and six per second positive spikes.


A simple cable for reduction of movement artifact in electroencephalographic recordings.


Failure of long-acting thyroid stimulator globulin (LATS) and serum to stimulate thyroid function in the chick.


The fine structure of the cuneate nucleus in normal cats and following interruption of afferent fibres. An electron microscopical study with particular reference to findings made in glees and nauta sections.


The acridine orange and dye exclusion viability tests applied to irradiated Ehrlich tumour cells.


Bacterial and viral coproantibodies in breast-fed infants.


Sarcoplasmic reticulum of striated muscle: localization of potential calcium binding sites. Fish branchial muscle stained at a low pH with thorium dioxide shows localization of the stain over the sacroplasmic reticulum. Binding of the positively charged thorium micelles with dissociated acid groups of polyanions in this region suggests a possible mechanism for the storage and release of divalent cations such as calcium.


Ontogenesis of the rat corticospinal tract. Normal events and effects of intra-uterine neurosurgical lesions.


Precapillary arteriovenous anastomoses. "Thoroughfare channels" in the brain.


Histology of rat molar pulp at different ages.


Immunofluorescent localization of the third and the fourth component of complement in synovial tissue from patients with rheumatoid arthritis.


Electroimmunodiffusion (EID): a simple, rapid method for quantitation of immunoglobulins in dilute biological fluids.


Frequency of secondary amyloidosis in hospital patients in Malawi.


Intralaminar distributions of proteolipid protein and residue protein in human frontal cortex.


Effects of age on dentin demonstrated with azure A.


Tubal metaplasia of the endometrium.

Tubal metaplasia of the endometrium.


Wiskott-Aldrich syndrome: clinical, immunologic, and pathologic observations.


Sixth National Burn Seminar. Control of sepsis in burns.


Sixth National Burn Seminar. The anabolic aspect of plasma protein metabolism in burn patients.


Pentagastrin as a stimulant of maximal gastric acid response in man. A multicentre pilot study.


Failure of high dialysis-fluid glucose to prevent the disequilibrium syndrome.


Finger-print pattern and the sex chromosomes.


Response to a gluten-free diet of patients with the coeliac syndrome.


Paneth-cell deficiency.

Paneth-cell deficiency.


The risk of recurrence after two children with central-nervous-system malformations.


Successful repeated platelet-transfusion in radiation-induced bone-marrow failure.


Haemodynamic consequences of atrial septostomy without thoracotomy in an infant with transposition of the great arteries.


Carcinoma of the nasal cavity and accessory sinuses in woodworkers.


Antinuclear factors in synovial fluids.

Antinuclear factors in synovial fluids.


Biochemistry of depression.

Biochemistry of depression.


Paneth-cell function.

Paneth-cell function.


Paneth cells and coeliac disease.

Paneth cells and coeliac disease.


Administration of teaching hospitals.

Administration of teaching hospitals.


The abortion bill.

The abortion bill.


Definition of suicide.

Definition of suicide.


The boundaries between physiology, pathology, and irreversibility after injury.


Immunohistological and serological studies in endomyocardial fibrosis.


Effects of sustained maternal hypertension on foetal growth and survival.


Haemodynamic factors in the development of acute pulmonary oedema in renal failure.


Effects of hyberbaric oxygen on shallow, stationary broth cultures of Escherichia coli.


A simple method for producing antibody specific to a single selected diffusible antigen.


Muscle antibodies in myasthenic mothers and their babies.


Effect of glucagon on insulin release in vitro.


Chromosomal abnormalities in human diploid cells infected with mycoplasma and their possible relevance to the aetiology of Down's syndrome (mongolism).


Standing-room only?

Standing-room only?


Blood-groups and the intestine.

Blood-groups and the intestine.


Academic deep freeze.

Academic deep freeze.


Industrial carcinogens: new legislation needed.


The multiplication of man or Noah's new flood.


The case against the promotion of health.


Brain damage after dental anesthesia.

Brain damage after dental anesthesia.


Chronic ethchlorvynol intoxication.

Chronic ethchlorvynol intoxication.


Guy Pascoe Crowden.

Guy Pascoe Crowden.


Charles Edward Kindersley.

Charles Edward Kindersley.


A controlled trial of antiserum in the treatment of tetanus.


The relation between glucose tolerance and atherosclerotic vascular disease.


Effect of short-term sucrose restriction on serum-lipid levels.


Reduction of haematocrit and red-blood-cell volume in patients with polycythaemia secondary to hypoxic lung disease by dapsone and pyrimethamine.


Effects of propranolol on the hormonal and metabolic responses to insulin-induced hypoglycaemia.


Hypoglycaemia precipitated by propranolol.


Antiperistaltic segments after massive intestinal resections.


Blood-gas tensions during apnoea in hyperbaric oxygen.


Precipitins against extracts of thatched roofs in the sera of New Guinea natives with chronic lung disease.


Training our specialists.

Training our specialists.


Evolution of sex chromosomes in mammals and birds.


The world's deformities.

The world's deformities.


Fire and hyperbaric oxygen.

Fire and hyperbaric oxygen.


Ignition by electrostatic sparks in hyperbaric oxygen.


Setting up a therapeutic community.

Setting up a therapeutic community.


Liberation of patients.

Liberation of patients.


Reaction after dichloralphenazone.

Reaction after dichloralphenazone.


A gamma-globulin genetic factor related to Gm(a) but localized to a different portion of the same heavy chains.


Rapid method for demonstrating intracellular pleuropneumonia-like organisms in a strain of hamster kidney cells (BHK 21 C13).


Peripheral neuropathy with bronchiectasis.


Development of the tracheal glands in man. Number, density, structure, shape, and distribution of mucous glands elucidated by quantitative studies of whole mounts.


Developmental and acquired variations in erythrocyte carbonic anhydrase isozymes.


Studies in vascular permeability of human skin bradykinin.


Role of mast cells in the inflammatory defense mechanism in the skin of rats.


Receptive fields in the accessory optic system of the rabbit.


The regenerative capacity of the telencephalon of the goldfish and rat.


Influence of stimulation of the septal area on visual evoked potentials.


A study of the distribution of epidermal dendritic cells in pigmented and unpigmented skin.


Surgical wound sepsis in a general hospital.


The bursa of Fabricius and the immune response. 2. An electrophoretic analysis of the spleen extracts of bursectomized animals.


Reaction of antinuclear factors with polymorphonuclear leucocytes. 1. Absorption studies.


The value of radiotherapy in the treatment of carcinoma of the colon.


Studies on the purification of the human serum group specific component.


Stainability of decalcified human coronal dentine.


Relationship between microradiography and stainability of human coronal dentine.


Staining mast cells in human gingiva.

Staining mast cells in human gingiva.


Vital staining and electron microscopy of the intramuscular nerve endings in the neuropathy of adult coeliac disease.


Neurological disorders associated with adult coeliac disease.


Mental deficiency associated with muscular dystrophy. A neuropathological study.


Histone differentiation and nuclear activity.


Electrophoretic heterogeneity of alpha-2-macroglobulin.


IgM light chain types in suspected macroglobulinaemia.


Resistance of differentiating neurons to the antimetabolite, amethopterin.


Effects of subthalamic lesions on sensory-evoked potentials in the reticular formation and sensorimotor cortex.


Free thyroxine levels in children with mongolism.


Some observations of renal function after prostatectomy.


Studies on the hemolytic titer of the complement and on the intensity of precipitation in the beta-1C globulins in the course of certain diseases.


Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. A renal tubular epithelial antigen is deposited in association with gamma globulin and complement in glomeruli from rats with experimental allergic glomerulonephritis induced by immunization with renal tubular antigens. Apparently, in normal kidneys this antigen is concentrated in the distal segment of the proximal convoluted tubular epithelium, and the principal source of this antigen in the glomerular deposits is autologous. This form of glomerulonephritis provides an experimental prototype for what may be termed "autologous immunecomplex" diseases.


Hereditary disorders of the retina and choroid.


Mast cells in gingival tissue. I. A standardized method for fixation and staining of the mast cell in human gingival tissue.


A generalized disorder of nervous system, skeletal muscle and heart resembling Refsum's disease and Hurler's syndrome. I. Clinical, pathologic and biochemical characteristics.


A generalized disorder of nervous system, skeletal muscle and heart resembling Refsum's disease and Hurler's syndrome. II. Ultrastructure.


Influence of pargyline on the toxicity of morphine and pethidine in mice.


Tinea Nigra. Report of five cases seen in Venezuela.


Investigation with tritiated thymidine of the relationship between the sex chromosomes, sex chromatin, and the drumstick in the cells of the female nine-banded armadillo, Dasypus novemcinctus.


Actinic elastosis and pseudoxanthoma elasticum.


Allotypic specificities in pigs. II. Types of frequency of allotypic specificities of gamma M globulin in pigs.


The in vitro activity of the microsomal fraction isolated from the spleen and the lymph nodes after immunization of the donor.


Studies of the proteins of secretions from two villous tumours of the rectum.


Calcium localized in odontogenic cells of rat mandibular teeth by the glyoxal bis (2-hydroxyanil) method.


Histochemical demonstration of the activity of phosphatases by means of leadrhodizonate.


Histochemical properties of insular beta-cells after short tryptic digestion.


Serum free thyroxine and thyroxine-binding protein studies in patients with supraventricular tachycardias.


Occurrence in thyrotoxicosis of a gamma globulin which protects LATS from neutralization by an extract of thyroid gland.


Studies of 47Ca metabolism in acromegaly.


Congenital goiter with hypothyroidism and iodo-serum albumin replacing thyroglobulin.


Regulation of the pituitary-thyroid axis in man: relationship of TSH concentration to concentration of free and total thyroxine in plasma.


Sex-related differences in the binding in serum of thyroid hormones.


Goitrous hypothyroidism induced by amino-glutethimide, anticonvulsant drug.


Familial syndrome combining deaf-mutism, stuppled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone.


Synthesis and pharmacology of 6-methylenedihydrodesoxymorphine.


The contribution of the precentral gyrus to the pyramidal tract of man.


Ribonucleic acid in canine mast cell granules and the possible interrelationship of mast cells and plasma cells.


Live attenuated mumps virus vaccine. 1. Vaccine development.


Immunoglobulin responses to experimental human infection with adenovirus types 26 and 27.


Comparison of several methods for isolation of rat peritoneal mast cells.


Molecular weight of human renin.

Molecular weight of human renin.


Persistent polioviral infection of the intact amniotic membrane. II. Existence of a mechanical barrier to viral infection.


Structure and heterogeneity of antibodies.


The involvement of a globulin fraction from serum and lymphoid cells in the passive transfer of contact allergy.


Passive transfer of a delayed skin reactivity to 2,4-dinitrochlorobenzene (DNCB) with the immunoglobulin A (IgA) fraction of serum and lymphoid cells.


Lattice corneal dystrophy. An inherited variety of amyloidosis restricted to the cornea.


Carcinoma of the male breast.

Carcinoma of the male breast.


A rapid semimicro method for determining protein-bound iodine.


Rabbit gamma A- and gamma M-immunoglobulins with allotypic specificities controlled by the a locus.


Light and heavy chain components of gamma globulins in urines of normal persons and patients with agammaglobulinemia. A heavy chain component of gammaG-globulins in normal urines has the characteristics of the proteolytic digestion product, Fc-fragment. This fragment is estimated to compose up to 15% of the gamma globulins present in urines. In contrast to urinary light chains, the urinary Fc-like fragment probably represents a catabolic component in normal gammaG-globulin metabolism. The light chains of the urine constitute more than half the total gamma globulin present. The calculated kappa/lambda ratio of light chains averaged 1.9 in ten urines, but the ratio in individual urines varied widely to either side of this figure. In two adult patients with agammaglobulinemia whose sera contained less than one-hundredth the normal gamma globulin levels, the urinary Fc-like fragment was absent, whereas the light chain levels were only one-tenth the average normal level. Treatment with exogenous gamma globulins resulted in normal or near normal Fc-like fragment excretion, whereas light chain excretion was only modestly affected.


Some observations on the ABO antigen sites of the erythrocyte membranes of adults and newborn infants.


Streptococcal related glomerulonephritis. II. Glomerulonephritis in rhesus monkeys immunologically induced both actively and passively with a soluble fraction from human glomeruli.


Characterization of human serum and nasal hemagglutinating antibody to Francisella tularensis.


Demonstration of tissue-specific soluble antigens in human skin by immunodiffusion.


Bacteriophage neutralizing activity of fragments derived from rabbit immunoglobulin by papain digestion.


Possible effects of various ototoxic drugs upon the ATP-hydrolyzing system in the stria vascularis and spiral ligament of the guinea pig.


Autonomous functioning nodules and thyrotoxicosis.


The neuropathy of sulfatide lipidosis (metachromatic leukodystrophy).


The hereditary tapetoretinal degenerations.


Immunosuppressive drugs in the management of malignant and severe rheumatoid arthritis.


Penicillin hypersensitivity with eosinophilia; a case report with immunologic studies.


Hypothalamic vasopressor and vesicopressor pathways. II. Anatomic study of their course and connections.


Hypothalamic vasopressor and vesicopressor pathways. I. Functional studies.


ATPase activity in discharging cortical lesions induced by freezing.


Fine structure of partially demineralized enamel.


Histological recognition of gingival reticulin.


Aldehyde fuchsin-Halmi reaction in fibres of the human dental pulp.


Protein adsorption on bovine enamel.

Protein adsorption on bovine enamel.


An electron microscopic study of the acquired pellicle and plaque formed on the enamel of human incisors.


Comparative fine structure of the trigeminal ganglia, including human autopsy studies.


Fine structure of the normal trigeminal ganglion in the cat and monkey.


Correlated light and electron microscopic observations on the normal trigeminal ganglion and sensory root in man.


Electron microscopy of the gasserian ganglion in trigeminal neuralgia.


Pathology of trigeminal neuralgia: light and electron microscopic observations.


Thymic alymphoplasia, lymphoma, and dys-gamma-globulinemia, hyper-gamma A-, normo-gamma M-, hypo-gamma G, a-gamma D-, and gamma E-globulinemia, plasmacytosis, normal delayed hypersensitivity, severe allergic reactions, and Coombs' positive anemia.


Liberation of histamine in man. Gas chromatography of ring methylated imidazoleacetic acids in urine.


Evidence for temporal and quantitative control of genetic transcription and translation during slime mold development.


Alpha-oxidation of branched chain fatty acids in man and its failure in patients with Refsum's disease showing phytanic acid accumulation.


Rodent plasmodia of the République Centrafricaine: the sporogony and tissue stages of Plasmodium chabaudi and P. berghei yoelii.


Heparin inhibition of histamine release and its relation to calcium.


Uptake and release of 3-H-histamine in cat submaxillary gland.


The insulin-like activity in serum determined by the rat epididymal fat method. VI. Insulin-like activity in serum and serum-protein fractions from normal persons and patients with diabetes mellitus.


Localization of plasma proteins in small dermal blood vessels in diabetes. Preliminary report.


Fractionation of mouse serum proteins. An evaluation of two methods with special reference to the gamma-globulins.


Comparison of Mycobacterium paratuberculosis and other mycobacteria, using standard cytochemical tests.


Selective staining of chromatin in hematogenous lymphocytes in nodes.


Visceral involvement in lipoid proteinosis.


Three-dimensional visualization of elastic fibers in thick skin sections.


The ultrastructure of negatively stained platelets. Some physiologic implications.


Electrographic correlates of behavior in the frog with special reference to sleep.


Sleep induction by progesterone in the pre-optic area in cats.


EEG studies during acidaemia and alkalaemia in children undergoing cardiac surgery.


EEG responses to light flashes during the observation of stabilized and normal retinal images.


Changes in visual recovery functions and unit activity produced by frontal and temporal cortex stimulation.


The formation and properties of organic films on teeth.


Effects of stimulation of the superior colliculus and lateral thalamus on visual evoked potentials.


Duration and frequency patterns of the after-discharge from septum and amygdala.


The relationship between neuron activity and cortical steady potentials.


Odontogenic myxoma: some histochemical considerations.


Discriminator and integrator instrument for an on line frequency analysis of single unit discharges.


Mental arithmetic and eye opening. An EEG frequency analysis and GSR study.


A chronically fixed stereotaxic device for intracerebral exploration with macro- and micro-electrodes.


A platinum micro-electrode for intracerebral exploration with a chronically fixed stereotaxic  device.


Testing metal micro-electrodes.

Testing metal micro-electrodes.


Periventricular Gomori-positive glia in the hypothalamus of the rabbit.


Somatotopical organization of the projection from the nucleus interpositus anterior of the cerebellum to the red nucleus. An experimental study in the cat with silver impregnation methods.


Embryology of the thyrotroph.

Embryology of the thyrotroph.


On the immunological nature of the long acting thyroid stimulator.


An attempt to establish a test for thyrotropin (TSH) reserve.


Electrophoretic evidence for the presence of an estrogen-binding beta-globulin in human plasma.


Transformations in glycyrrhetinic acid: rearrangement of ring A.


Effect of maternal ingestion of iophenoxic acid (Teridax) on protein-bound iodine: report of a family.


A neutrophil cycle in healthy individuals.


Diffuse thinning of hair in iodide-induced hypothyroidism.


Follicular hyperkeratosis and ocular abnormalities associated with Fairbank's syndrome.


Diagnosis of gonorrhea by a fluorescent antibody technique.


Polycyclic aromatic hydrocarbons in common Japanese foods. I. Broiled fish, roasted barley, shoyu, and caramel.


Studies of human anti-gamma-globulin factors reacting with pepsin-digested gamma-globulins. Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhibit these agglutination reactions. Low molecular weight inhibitors show both auto- and isospecificity, and are antigenically related to the 5S pepsin fragment of gamma-globulin. A common situation is thereby revealed in which human anti-gamma-globulin antibodies showing specificity for pepsin-digested gamma-globulins are present in serum along with low molecular weight gamma-globulin components capable of inhibition. Autoreactivity or autospecificity of such anti-gamma-globulin factors is a phenomenon shared by both normal human sera and sera from patients with various disease states.


Studies on rabbit lymphocytes in vitro. V. The induction of blast transformation with sheep antisera to rabbit IgG subunits. The addition of sheep antisera to rabbit IgG or to rabbit IgG subunits (L chain, H chain, Fab piece, Fc piece) to in vitro cultures of rabbit peripheral lymphocytes may induce up to 80-90% of the small lymphocytes to transform into immature "blast" cells. As many as 1 x 10(7) molecules of antibody may be required to stimulate each cell. It is concluded that each peripheral lymphocyte carries the antigenic specificities of the entire IgG molecule and thus could carry, and may produce specific antibody molecules. Such a conclusion supports the theory that the small lymphocyte may be the site of specific recognition of antigens in the primary response.


Heavy chain subclasses of human gamma G-globulin. Serum distribution and cellular localization. Two antigenic types of naturally occurring proteins related to the papain produced F(c) fragment of gammaG-globulin have been studied. Most normal and myeloma gammaG-globulins are related to one or the other of these proteins, based on antigenic and structural characteristics of their heavy chain. Molecules bearing the determinant "Cr" are approximately 10 times as abundant as those bearing the determinant termed "Zu" in pools of normal gammaG-globulin and among a large group of gammaG-myeloma globulins. Both populations have properties of typical gammaG-globulin antibodies. Splenic cells, stained for these two populations with specific fluorescent antibody preparations, are found to contain one or the other of the two populations of gammaG-globulin, but not both. Approximately 10 times as many cells contain the Cr determinant as contain the Zu determinant.


Thyromimetics. V. The synthesis and biological screening of alpha-methylthyroxine.


Purification and activity of growth-promoting alpha-globulin for cells in cultures.


Overhead projectors in nurse training.

Overhead projectors in nurse training.


Use of the silver-hydroquinone sequence for the display of reticular fibers.


Pollen tube mitosis in culture; osmotic control and acenaphthene treatment.


Rapid demonstration of juxtaglomerular granules in mammals and birds.


A resinous mounting medium compatible with azo-dye staining for alkaline phosphatase.


A convenient method for processing fetuses for skeletal staining.


Erythema nodosum.

Erythema nodosum.


Erythema chronicum migrans (Afzelii) associated with mosquito bite.


Some immunological properties of guinea pig skin-saline suspension. 3. Skin lesions produced in guinea pigs by rabbit dermatotoxic serum.


Sensitization to the neomycin group of antibiotics. Patterns of cross-sensitivity as a function of polyvalent sensitization to different portions of the neomycin molecule.


Specific fluorescence in guinea-pig melanocytes.


Cytochemical reactions of basophil leukocytes. V. Sudan black B staining.


Processing cryostat sections of formalin-fixed tissues.


Rapid fluorescein and protein assay method for fluorescent-antibody conjugates. A method is presented for the rapid determination of the fluorescein content, protein content, and fluorescein-to-protein ratio for immune globulin conjugates with fluorescein isothiocyanate as the fluor. This method is based on the absorbance of the fluorescent antibody at those wavelengths primarily associated with the fluorescein and gamma-globulin fractions, and permits these materials to be determined by a single nondestructive analytical procedure. A small sample of the fluorescent antibody, in many cases 0.1 ml or less, is adequate for the above determinations. A nomograph is presented which allows simultaneous determination of the materials from the observed absorbance at the two wavelengths. The method is sufficiently accurate for most applications of the fluorescent-antibody techniques. Although this procedure has been developed primarily for fluorescent-antibody conjugates prepared from rabbit gamma-globulin, it can be used directly for antibodies prepared from other animals provided the gamma-globulin is relatively free from albumin.


Appearance of pre-alpha-2-globulins soon after the very first dose of diphtheria toxoid in horse.


A simple technique for the preservation of vital dyes in fixed and sectioned embryos.


Thyroid status in pregnancy and in women taking oral contraceptives.


Venous/arterial pulmonary shunting as the principal cause of postoperative hypoxaemia.


In-vitro activity of cephalothin/kanamycin and methicillin/kanamycin combinations against methicillin-resistant Staphylococcus aureus.


The significance of bacteriuria in pregnancy.


Blood-volume changes in severe anaemia in pregnancy.


The long-term prognosis of severe infantile malnutrition.


Treatment of early Hodgkin's disease.

Treatment of early Hodgkin's disease.


Motes and beams.

Motes and beams.


Neuronal membrane patterns in memory and concussion.


Monitoring of drugs.

Monitoring of drugs.


Glandular-fever cells.

Glandular-fever cells.


The health of students.

The health of students.


Hepatic cirrhosis and diabetes mellitus.


Chromosome breakage and leukemia.

Chromosome breakage and leukemia.


Radiologists and radiation.

Radiologists and radiation.


Antihistamine treatment and drug eruptions.


Children and death.

Children and death.


F.A.O. comes of age.

F.A.O. comes of age.


Hemodialysis in poisoning with methaqualone and diphenydramine.


Red eyes in renal failure.

Red eyes in renal failure.


Hematological side-effects of diazoxide.


Walter Russell Brain. Baron Brain of Eynsham.


Arterial blood-gas tensions and pH in acute lower-respiratory-tract infections in infancy and childhood.


Efficacy of topically applied progestational agents.


Orthotopic autotransplantation and allotransplantation of the liver: functional and structural patterns in the dog.


Long-term culture of lymph node tissue from a patient with lymphocytic lymphoma. II. Preliminary ultrastructural, immunofluorescence and cytogenetic studies.


Induction of proliferative synovitis in rabbits by intra-articular injection of immune complexes.


Observations on the deposition, structure, and cytochemistry of the jelly envelopes of the egg of the newt, Triturus viridescens.


Intrathyroidal exchangeable iodine in endemic goiter in Misiones, Argentina.


Protein-bound iodine level during childhood and adolescence.


Acceleration of thyroxine and triiodothyronine turnover during bacterial pulmonary infections and fever: implications for the functional state of the thyroid during stress and in senescence.


Modern developments in teaching methods.


The nature of the "basement membrane" in human gingiva.


Electrophoretic mobilities of serum gamma-glutamyl transpeptidase and its clinical application in hepatobiliary disease.


Conservative resection in surgery for bronchogenic carcinoma.


Experience with palliative resection and irradiation therapy for carcinoma of the lung.


Dermal connective tissue in patients with chronic obstructive airways disease.


Gastric function in patients with gastric carcinoma.


Treatment of urinary schistosomiasis with niridazole (Ambilhar) in 576 African schoolchildren.


Haemophilus influenzae precipitins in the serum of patients with chronic bronchial disorders.


Capsulated Haemophilus influenzae and respiratory-tract disease.


Rapid rise of insulin concentration in the plasma after intravenous administration of sodium tobutamide.


Need for glucagon in severe hypoglycaemia induced by sulphonylurea drugs.


Epilepsy and driving.

Epilepsy and driving.


Microscopy of the cancer cell as a guide to cancer chemotherapy.


A day hospital for disturbed children under five.


Serological investigations in suspected brucellosis.


Effect of interhemispheric transection on the EEG patterns in sleep and wakefulness in monkeys.


Morphological and chemical studies of Nauta-stained degenerating cerebellar and hypothalamic fibers.


Spinal afferents to the lateral reticular nucleus. I. An histological study.


Cytoarchitectonic study of the isocortex in the sloth (Choloepus hoffmanni Peters).


Patterns and mode of termination of cerebellar cortico-nuclear pathways in the monkey (Macaca mulatta).


Observations of the development of the nucleus of Edinger-Westphal in man and the albino rat.


The naso-temporal division of the cat's retina.


The projection of the cat's retina on the lateral geniculate nucleus.


Muliaxonal autonomic junctions in intestinal smooth muscle of the toad (Bufo marinus).


Vaccinia Gangrenosa with normal humoral antibodies. A case possibly due to deficient cellular immunity treated with N-methylisatin beta-thiosemicarbazone (Compound 33T57, Marboran).


Localized scleroderma. A histochemical and chemical study.


Purpura hyperglobulinemia.

Purpura hyperglobulinemia.


Comparison between FA factor and LE cell tests.


Malacoplakia. Discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement.


Effect of actinomycin on the synthesis of macromolecules in Escherichia coli.


Stimulation of polypeptide synthesis by artificial nucleoproteins.


No more measles?

No more measles?


The effect of bilateral adrenalectomy on induced benign prostatic hyperplasia in mice.


Some urological aspects of 93 consecutive renal homotransplants in modified recipients.


Succinylation of gamma globulin.

Succinylation of gamma globulin.


Widely distributed necrotic arterial lesions induced in rabbits by experimental renal alterations. VI. Demonstration of antigenic determinants of gamma-globulin and of thrombin-clottable plasma protein in arterial lesions: uptake of guinea pig complement in vitro.


Stable bromine and activation analysis in protein tracer studies.


The elusive trigger mechanism of endotoxin shock.


Refsum's disease.

Refsum's disease.


The cytopathic action of purified staphylococcal delta-hemolysin.


Production of alpha-1-globulins by the perfused rat liver.


The frequency and pattern of normal tremor.


Inhibition of visual evoked responses to patterned stimuli during voluntary eye movements.


Non-primary sensory projections on the fronto-orbital cortical area in the cat.


EEG synchronization induced by high frequency midbrain reticular stimulation in anesthetized cats.


Changes in electrical activity of the cerebral cortex and of some subcortical centers in hyperbaric oxygen.


Relationships between EEG patterns and arterial pressure changes.


EEG findings in late infantile metachromatic and globoid cell leucodystrophy.


Vestibular influences upon the EEG of epileptics.


Observations on high frequency electroencephalograms.


Diagnostic recording of somato-sensory cortical evoked potentials in man.


Intrinsic and induced EEG rhythms in severe hypothyroidism secondary to panhypopituitarism. A case report.


An averaging method for determination of temporal relationship between epileptogenic foci.


Monopolar rheoencephalography.

Monopolar rheoencephalography.


Interglobular dentine and the calcospherite pattern.


New subminiature amplifier-transmitters for telemetering biopotentials.


An antaminic drug, BC 105, in the prophylaxis of migraine. Pharmacological, clinical, and therapeutic experiences.


Quantitative immunoglobulin levels (IgG, IgA and IgM) in children.


Experimental eosinophilia. IX. Effects of immunosuppressive agents on eosinophil cell responses.


Studies on the radiosensitive phase of the primary antibody response in rabbits. I. The role of the macrophage.


Application of the paired label radioantibody technique to tissue sections and cell smears.


Antibodies against human leukemia cell lines.


Tumors in amphibians. I. Histology of a neuroepithelioma in Siredon mexicanum.


A simple immunoelectrophoretic method for demonstrating deficiency of the beta-1A-C component of complement in serum.


Combining the antidepressant drugs.

Combining the antidepressant drugs.


Abdominal wound disruption.

Abdominal wound disruption.


Immunoglobulins.

Immunoglobulins.


Some studies on the effects of radiation and radiation modifiers on growing hair.


Peritoneal atrial shunt for intractable ascites.


Transrectal needle biopsy of the prostate.


Preparation of nonthrombogenic plastic surfaces.


Geriatric surgery. Immediate postoperative care and treatment with special reference to cardiovascular, cerebral, and pulmonary complications.


Panorama of surgical diseases in the aged.


Geriatric urology.

Geriatric urology.


Results of geriatric surgery.

Results of geriatric surgery.


Ten years' experience of geriatric aspects in surgery of patients with benign prostatic hyperplasia.


Vital staining of the canaliculus lacrimalis and the palpebral border (Marx' line).


Studies in oral leukoplakias. 10. Periodic-acid-Schiff staining of normal and leukoplakic epithelium before and after vitamin A application.


Histologic parallels between mastocytoma and melanoma. Demonstration of melanin in tumor cells of mastocytoma and metachromasia in tumor cells of melanoma.


The role of soluble aggregates in the primary immune response of mice to human gamma globulin.


Some aspects of the structural organization of the myofibril as revealed by antibody--staining methods. FROM OBSERVATIONS OF FLUORESCENT ANTIBODY STAINING AND ANTIBODY STAINING IN ELECTRON MICROSCOPY, EVIDENCE IS PRESENTED FOR THE FOLLOWING: (a) Direct contact of the actin and myosin filaments occurs at all stages of contraction. This results in inhibition of antibody staining of the H-meromyosin portion of the myosin molecule in the region of overlap of the thin and thick filaments. (b) Small structural changes occur in the thick filaments during contraction. This leads to exposure of antigenic sites of the L-meromyosin portion of the myosin molecule. The accessibility of these antigenic sites is dependent upon the sarcomere length. (c) The M line is composed of a protein which is weakly bound to the center of the thick filament and is not actin, myosin, or tropomyosin. (d) Tropomyosin as well as actin is present in the I band. (e) If actin or tropomyosin is present in the Z line, it is masked and unavailable for staining with antibody.


The loss of phenotypic traits by differentiated cells. 3. The reversible behavior of chondrocytes in primary cultures. Observations were made on the behavior of chondrocytes grown under various conditions in vitro. The chondrocytes in 10-day embryonic chick vertebrae were grown as cultures of intact vertebrae, as pellets of chondrocytes liberated from their matrix, and as monodispersed cells plated out on plasma clots. Cartilage matrix was stained metachromatically with toluidine blue. Radioautographs were made of incorporated H(3)-thymidine, H(3)-proline, and S(35)-sulfate to determine the extent of DNA synthesis, collagen synthesis, and chondroitin sulfate synthesis, respectively. Chondrocytes in intact vertebrae or in pellets are rounded and actively synthesizing chondroitin sulfate and collagen. There is little DNA synthesis by cells in either vertebrae or pellets. Chondrocytes grown as monodisperse cells rapidly cease synthesizing cytologically detectable chondroitin sulfate and are induced to synthesize DNA and divide. There is a change in the shape of these chondrocytes from a rounded to a more stellate condition which accompanies the shift in metabolic activity. Conversely, when the cells attain a certain cell density, they reacquire a rounded shape, cease dividing, and again synthesize chondroitin sulfate. Clusters of chondrocytes synthesize more chondroitin sulfate than isolated chondrocytes. It is concluded that most chondrocytes synthesizing chondroitin sulfate do not concurrently synthesize DNA. Interaction between associated chondrocytes is important in inducing and maintaining chondroitin sulfate synthesis in genetically determined chondrocytes. Failure of interaction between chondrocytes leads to DNA synthesis and cell multiplication.


Studies on thyroid function in malnourished infants and children in Egypt.


The fine structure of the ribonucleoprotein in bacterial cytoplasm.


A simple method of preparing protein-erythrocyte conjugates for hemagglutination tests.


Sites of production of primate serum proteins associated with complement system.


Comparative immunology. Active immunization of young alligators with hemocyanin.


Specific heterophile antibody from infectious mononucleosis serum.


Reduced biological effectiveness of orally administered L-thyroxine in the rat in the presence of blood plasma.


Eosinophils and histamine in Asboe-Hansen's disease (incontinentia pigmenti). Studies with the skin window technique.


Immunoelectrophoretic study of biological false positive serum reactions for syphilis.


The effect of prolonged thiazide administration on thyroid function.


Systemic lupus erythematosus and multiple sclerosis in identical twins.


Fine structure of meiotic chromosomes. Comparative study of nine species of insects.


Release of histamine into gastric venous blood following injury by acetic or salicylic acid.


An in-service training program for dietary employees.


Rabbit macrophage interferons. I. Conditions for biosynthesis by virus-infected and uninfected cells. Interferon is produced in cultures of rabbit leukocytes in response to infection with Newcastle disease virus or in the absence of known viral infection. The macrophage appears to be the responsible producing cell. Cultures prepared from sterile peritoneal exudates, which contained about 90% macrophages, are at least as efficient as cultures of rabbit kidney (RK) cells in their capacity to synthesize NDV-induced interferon. Interferon can be detected in the medium by 2 hr after viral infection and the titers usually reach a peak of 10,000 PDD(50)/ml by 4-6 hr. Exposure to actinomycin prior to or shortly after viral induction effectively blocks interferon synthesis by cells of both types. However, macrophages become refractory to actinomycin by 30-60 min compared with 607-120 min for RK cells, a finding which suggests earlier and more rapid transcription of interferon-specific messenger RNA in macrophages. Macrophages harvested from the peritioneal cavity of rabbits injected intravenously with NDV 48 hr previously also exhibit slightly reduced capacity to synthesize interferon, but this tolerant state is less marked than is tolerance to production of circulating interferon in intact rabbits. Interferon is also synthesized by rabbit macrophages not infected with virus but simply incubated at 37 degrees C in medium with or without added bacterial endotoxin. Uninfected polymorphonuclear leukocytes, rabbit kidney and spleen cells produced no detectable interferon under similar conditions of cultivation. No interferon was released by intact macrophages incubated at 4 degrees C or by ultrasonically disrupted macrophages incubated at 37 degrees C. Although interferon titers were found to be higher when uninfected cultures were exposed to 10-100 microg/ml of E. coli lipopolysaccharide, unavailability of suitable pyrogen-free maintenance media precluded answering the question whether macrophages can continually synthesize and release interferon spontaneously. Interferon yields from uninfected macrophages were only 1% or less of the yields from NDV-infected macrophages, but the rates of synthesis were similar under both conditions. Studies with actinomycin and puromycin revealed that sequential transcriptive and translational events are required for de novo interferon synthesis by uninfected cells in a manner similar to virus-induced interferon synthesis. The physical properties and molecular weights of these rabbit interferons are discussed in the following report (12).


Histamine releasers. I. Structure of the dimer formed from p-methoxy-N-methylphenethylamine and formaldehyde.


Voluntary male sterilization.

Voluntary male sterilization.


Studies with radioactive copper (64Cu and 67Cu) in relation to the natural history of Wilson's disease.


A self-releasing inferior vena caval clip.


Immunoglobulin synthesis within the central nervous system in disseminated sclerosis.


Creation of atrial septal defects by balloon catheter in babies with transposition of the great arteries.


Fatal granulomatous disease of childhood and benign lymphocytic infiltration of the skin (congenital dysphagocytosis).


Antibiotic-resistant streptococci in the mouths of children treated with penicillin.


Hypothermia in kwashiorkor.

Hypothermia in kwashiorkor.


Gallstones, gastric secretion, and flatulent dyspepsia.


The performance of nasal catheters and a face mask in oxygen therapy.


Hypofibrinogenaemia without increased fibrinolysis in leukaemia.


Leucocyte-excretion rate as a screening test for bacteriuria.


Treatment of primary biliary cirrhosis with azothioprine.


Metabolic precursors of methylmalonic acid in vitamin-B12 deficiency.


Tedium and the law of diminishing returns in clinical biochemistry laboratories.


Joseph Bamforth.

Joseph Bamforth.


Abnormal urinary steroid excretion and subsequent breast cancer. A prospective study in the Island of Guernsey.


Fasting blood-sugar and serum-growth-hormone in hypopituitary diabetics.


Subjective assessment and objective measurement of finger clubbing.


A controlled trial of artificial respiration in the respiratory-distress syndrome of the newborn.


Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset diabetes.


A simple scoring system for classifying the severe forms of protein-calorie malnutrition of early childhood.


Addison's disease and Addisonian anaemia.


Precipitating antibodies to aspergillus fumigatus in cystic fibrosis.


Measles-virus antibody and antigen in subacute sclerosing panencephalitis.


A simple method for determining selectivity of proteinuria.


Effect of intrinsic factor on absorption of vitamin B12 from small intestine.


Epithelial changes in the uterine cervix.


Efficient use of blood.

Efficient use of blood.


A defence against viruses.

A defence against viruses.


A unique endeavour.

A unique endeavour.


Another kind of measles encephalitis?

Another kind of measles encephalitis?


The handicapped child at school.

The handicapped child at school.


Central action of chlorpromazine.

Central action of chlorpromazine.


A controlled trial of inpatient and outpatient treatment of alcohol dependency.


Resident hospital doctors' families.

Resident hospital doctors' families.


Pet meat as a potential source of human salmonellosis.


Medical ethics today. A student's uncertainties.


From medical science to medical care. Public policy, the resultant of private policies.


Hereditary coproporphyria.

Hereditary coproporphyria.


Antibodies in the families of thyrotoxic patients.


Streptococcus pyogenes, type 49. A nephritogenic Streptococcus with a wide geographical distribution.


Blood-gas tensions in bronchial asthma.

Blood-gas tensions in bronchial asthma.


Multiple serotypes of vibrio cholerae isolated from a case of cholera. Evidence suggesting in-vivo mutation.


Autoimmunity in gonadal dysgenesis and Klinefelter's syndrome.


In-vitro variation of viscosity of body fat during cooling.


Acid and bicarbonate secretion in health and disease.


Salt loading as a possible factor in the production of potassium depletion, rhabdomyolysis, and heat injury.


Flexible renal grid-sling for localising stones during lithotomy.


Diagnostic tests in the porphyrias.

Diagnostic tests in the porphyrias.


Adult coeliac disease and neuropathy.

Adult coeliac disease and neuropathy.


Evaluation of a method of prescribing drugs in hospital, and a new method of recording their administration.


National or personal health service?

National or personal health service?


Measurement and control of drug-administration incidents. Observation was used to measure the extent of errors in prescribing and administering drugs in a medical ward of the London Hospital.  A working-party with medical, nursing, pharmaceutical, work study, and administrative representation was established to examine the problem.  An error incidence of 15.3% was found.  Variations on the established system were introduced to determine if this incident rate could be reduced.  4 experiments were conducted to test the more important of these improvements.  In the 1st experiment a pharmacist went to the ward each morning and inspected each drug sheet.  Where new prescriptions required dispensing, the drug label was written in the ward and taken to the pharmacy.  The pharmacy service was withdrawn in the 2nd experiment, and a redesigned drug sheet was introduced.  The 3rd experiment tested the effects of the items in the 2nd experiment with the addition of a locking trolley.  A combined drug-prescription and recording sheet were introduced in the 4th experiment to reduce clerical work on the part of nurses by eliminating the duplication of data onto recording documents and to provide doctor, nurse, and pharmacist with a feedback of information at the bedside.  The introduction of a redesigned drug sheet along with other modifications appeared to be associated with a reduction of errors in prescribing and administering drugs to 4.2% of the drugs given.


Cerebral thrombosis and oral contraception.


Jaundice and oral contraceptives.

Jaundice and oral contraceptives.


Barbiturate poisoning.

Barbiturate poisoning.


Aspirin for young children.

Aspirin for young children.


Fatal benzene exposure by glue-sniffing.


Effect of phosphate supplements in patients with fractures.


Placental transfer of gastric antibodies.


Quantitative radiological and histological studies of the thymus in thyroid disease.


Haemophilia Bm: a new type of factor-IX deficiency.


Effect of strenuous  and graded exercise on fibrinolytic activity.


Partial-thickness skin grafting of fingertip injuries.


Primary hypomagnesaemia with secondary hypocalcaemia in an infant.


Magnesium and malnutrition.

Magnesium and malnutrition.


The masking of antigens on trophoblast and cancer cells.


The thymus gland and autoimmunity.

The thymus gland and autoimmunity.


International classification of tumours.


Fingertip injuries.

Fingertip injuries.


Management of phaeochromocytoma.

Management of phaeochromocytoma.


Myotonia produced by an unknown humoral substance.


Palliative treatment of metastatic carcinoma of the liver by hepatic artery infusion with 5-fluorouracil: report of a case.


Leiomyosarcoma of the bladder: case report with autopsy.


Influence of prior sensitization with mycobacteria on antibody response to protein antigen in Freund's adjuvants.


Antibodies to corticotrophin and their relation to adrenal function in children receiving corticotrophin therapy.


Increase in RNase and DPNase activities in ascites tumor cells induced by various cytostatic agents.


Molecular size of gamma-A-immunoglobulin from bronchial secretions.


Simple test for insulin antibodies in sera, using 131-I-insulin and ethanol precipitation.


Slide projection for small groups.

Slide projection for small groups.


Immunoglobulins in the conjunctiva.

Immunoglobulins in the conjunctiva.


Characterization of rat IgA and its non-identity with the anaphylactic antibody.


Relationship between ragweed-reagins and serum immunoglobulins.


Relationship of normal human serum immunoglobulins to blocking of Prausnitz-Küstner sensitization.


Evidence that the two ribosomal RNA species of plant tissue are synthesized on different genetic loci.


Comparative study between immunoglobulin status and interferon response in health and disease.


The binding of immune globulins and other proteins by polystyrene latex particles.


Endomyocardial fibrosis in Europeans resident in tropical Africa.


Skin flora of the newborn.

Skin flora of the newborn.


Simple goitre in Glasgow and Dumfries schoolchildren.


Effects of octanoic acid on serum-levels of free fatty acids, insulin, and glucose in patients with cirrhosis and in healthy volunteers.


Therapeutic hazards of phenylbutazone and oxyphenbutazone in polymyalgia rheumatica.


Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics.


Intravascular haemolysis and disseminated intravascular coagulation.


Hypoglycaemic effect of adipose-tissue extracts in adrenalectomised rats.


Bacterial endocarditis: a changing pattern.


Capsulated haemophilus influenzae.

Capsulated haemophilus influenzae.


Pneumocystis carinii pneumonia.

Pneumocystis carinii pneumonia.


Oxygen by face mask and nasal catheter.

Oxygen by face mask and nasal catheter.


Inotropic effect of quinidine.

Inotropic effect of quinidine.


Significance of disappearance-rate of injected insulin.


Potassium, glucose, and insulin in myocardial infarction.


Testing for hypoparathyroidism.

Testing for hypoparathyroidism.


Serum-creatine-phosphokinase levels.

Serum-creatine-phosphokinase levels.


Phenylthiocarbamide and mental immaturity.


Small-bowel changes in ichthyosis.

Small-bowel changes in ichthyosis.


Haematological effects of methyldopa.

Haematological effects of methyldopa.


Glandular-fever cells.

Glandular-fever cells.


Erythrocyte lipids in Tay-Sachs disease.


Propranolol and hypoglycaemia.

Propranolol and hypoglycaemia.


Electron microscopic identification of autonomic nerve endings.


Histochemical observations on the lipids of carious human dentine.


Location of spore and vegatative antigens of Bacillus cereus by means of ferritin-labelled antibodies.


Systemic lupus erythematosus.

Systemic lupus erythematosus.


Determination of serum thyroxine. The diagnostic value in thyroid diseases.


Cultured mammalian cell deoxyribonucleic acid as a template for in vitro protein synthesis.


Bacterial antigens and aggregated gamma globulin in the lesions of nodular vasculitis.


Interaction of 14C-labeled human and bovine growth hormone with serum proteins.


Autosensitization and multiple sclerosis.


Thyroid activity in mice with hypothalamic lesions induced by goldthioglucose.


Studies on the mechanism of action of liver extracts in inhibiting uptake of 131-I in vitro by the rat thyroid gland.


The microcrystalline structure of cellulose in cell walls of cotton, ramie, and jute fibers as revealed by negative staining of sections. With a new technique of negative staining of sections, it has been possible to observe directly, in ultrathin sections under the electron microscope, the original microcrystalline and microfibrillar structure of cellulose as it occurs in living cells. This method has advantages over the study of isolated fibers used so far by others, in that the original arrangement of microfibrils is better preserved, and their collapse into larger fibrillar units is prevented. With this method, the cell walls of ramie, jute, and cotton fibers have been studied. The size (diameter, 25 to 40 A) and the longitudinal periodicity observed in the single microfibrils and the orientation and spatial arrangement of the microcrystallite within the microfibrils are found to correspond with the latest models derived by others from data obtained by indirect methods such as X-ray diffraction. The microfibril size of about 35 A, found by measuring these structures in sections, agrees with the latest conclusions reached by others in recent work with isolated fibrils.


The importance of osmiophilia in the production of stable azoindoxyl complexes of high contrast for combined enzyme cytochemistry and electron microscopy.


The effect of trypan blue on the postnatal development of serum proteins.


Mitigation of secondary disease in mice receiving bone marrow from donors pretreated with cortisone and alkylating agents.


Observations on the relationship between the maximal thyroxine binding capacities of thyroxine-binding interalpha globulin and thyroxine-binding prealbumin, the serum protein bound iodine concentration and sexual maturity in adolescents.


Compartmentalization and turnover of 131-I-labeled albumin and gamma globulin in horses.


Microscopic anatomy of the integument of adult swine.


Chemotherapy of renal leptospirosis in hamsters.


The problem of the coronary changes due to disturbance of vascular wall permeability.


Disc electrophoretic studies of human perilymph.


Innervation of the human cochlea.

Innervation of the human cochlea.


Modification of stress responses in histamine-depleted rats.


A cytocidal system in normal human serum active against Ehrlich Lettré ascites tumor cells. I. Identification of the components of the system and site of attachment.


Histological demonstration of mucosal invasion by Giardia lamblia in man.


Ultrastructural studies of the human Giardia lamblia and subjacent jejunal mucosa in a subject with steatorrhea.


Some biological activities associated with the 10S form of human gamma-G-globulin.


Inhibition of the anti-globulin reaction by human immunoglobulin G and its fragments.


Electrophoretic studies of the conversion products of serum beta-1C-globulin.


Bacteriostatic effects of horse sera and serum fractions on Clostridium welchii Type A, and the abolition of bacteriostasis by iron salts.


Quantitative studies of immunofluorescent staining. I. Analyses of mixed immunofluorescence.