Oral pathology in focus.

Oral pathology in focus.


Magnesium starvation of Aerobacter aerogenes. IV. Cytochemical changes. A number of cytochemical changes were revealed by microscopic observations of Aerobacter aerogenes populations starving for Mg(++). During the first few hours, while the synthesis of deoxyribonucleic acid (DNA) was paralleled by an increase in viable bacteria, the cells became progressively smaller. Subsequently, the number of viable cells in the culture remained constant in spite of continuing DNA synthesis, and the cells progressively elongated into filamentous forms. During this time, a second population of very small bacteria could be identified. These cells, whose number increased progressively, were inert with respect to (i) growth or reproduction when returned to a complete medium and (ii) biosynthetic activity as judged by autoradiographic estimation of uracil-H(3) incorporation into nucleic acids. When observed by electron microscopy, many thin sections from bacteria that had been starved of Mg(++) for 20 hr appeared to be almost devoid of ribosomal particles. Thionine staining indicated that the inert cells contain DNA. Furthermore, the rate of DNA synthesis in the culture corresponded to the rate of accumulation of inert cells, suggesting that their presence can account for the difference between total DNA and viable count.


Influence of fixation on gross morphology of Mycoplasma.


Acid treatment modification for the preparation of permanent slides of l forms and mycoplasmas.


Simple method of detecting spore septum formation and synchrony of sporulation.


Effective chemotherapy in children with Wilms' tumor.


Poly C synthetase activity in the particulate fraction of rat brain nuclei.


Morphological observations on some diphtherial phages.


Localization of the small-intestinal disaccharidases.


Regulation of acetohydroxy and synthetase in streptomycin-dependent Escherichia coli.


Anemia and cholesterolemia during estrus and pregnancy in the Beagle.


Regulation of acetohydroxy acid synthetase in streptomycin-dependent Escherichia coli K-12.


Effects of pyridoxine deficiency and dietary cholesterol supplementation in the chick on plasma protein-bound iodine, glutamic-oxalacetic transaminase activity, and 14-C-acetate incorporation into cholesterol.


Cytochemical and chromatographic demonstration of platelet histamine release by antigen-antibody reaction in vitro.


Permanent stained agar preparation of Mycoplasma and of L forms of bacteria. A procedure is described that permits the preparation of permanent stained mounts of Mycoplasma and of bacterial L forms grown on the surface of and within agar media. These preparations are especially useful for making representative photographs. The cultures are fixed with Formalin vapor. Thin slices of agar are stained at elevated temperature between 50 and 60 C and at a low pH, are dried rapidly, and are mounted in Canada balsam. The results with this staining procedure are illustrated by photographs of various strains of Mycoplasma and of bacterial L forms.


Evaluation of polyvinyl alcohols as semipermanent mountants for fluorescent-antibody studies.


Immunologic unresponsiveness to allergic thyroiditis in guinea pigs.


Role of the thymus in tolerance. V. Suppressive effect of treatment with nonaggregated and aggregated bovine gamma-globulin on specific immune responses in normal adult rats.


Cytological study of amniotic fluid with Nile blue sulphate staining.


Allergen-binding activity of gamma-E, gamma-G and gamma-A antibodies in sera from atopic patients. In vitro measurements of reaginic antibody.


An effect upon the regulation of gene expression: allotype suppression at the a locus in heterozygous offspring of immunized rabbits.


Synthesis of human immunoglobulins in germinal centers of lymphoid organs.


Enhanced immunologic sensitization of mice by the simultaneous injection of antigen and specific antiserum. 3. The role of antigen in controlling the immune response elicited with immune complexes.


Alcian-PAS positive granules in mesothelioma and mesothelial cells.


Interaction of rabbit anti-human H chain sera with denatured human gamma-globulin and its subunits.


Interaction of rheumatoid factors with urea-denatured human gamma-globulin and its subunits.


Treatment of haemophilia (factor-8 deficiency) with human antihaemophilic factor prepared by the cryoprecipitate process.


Chromosome anomalies in primary lymphoedema.


Role of insulin in glucose intolerance in uraemia.


Bacterial L-forms in relapsing urinary-tract infection.


Measurement of blood-pressure in the leg.


Adrenal adenoma and hypertension.

Adrenal adenoma and hypertension.


Treatment of phobic patients by systematic desensitisation.


Non-specific ulcerative colitis in Bedouin Arabs.


Platelet adhesiveness in experimental scurvy.


An unusual neurological manifestation of hypocalcaemia.


Foolproof tap systems for manometry.

Foolproof tap systems for manometry.


Failure of insulin response to glucose load during operation and after myocardial infarction.


Patient demand.

Patient demand.


Anaesthetics and the heart.

Anaesthetics and the heart.


Streptococci and rheumatic fever.

Streptococci and rheumatic fever.


Crisis at adolescence.

Crisis at adolescence.


Early operation in acute piles.

Early operation in acute piles.


Intravenous anaesthesia for dental surgery.


Learning to read.

Learning to read.


Epilatories and depilatories.

Epilatories and depilatories.


The case for a new maternity-bed ratio.

The case for a new maternity-bed ratio.


A national standard for anticoagulant therapy. The Manchester comparative reagent.


Multiple-screening tests in Glasgow men aged over forty-five years.


Voluntary eradication of brucellosis.

Voluntary eradication of brucellosis.


Vinca alkaloids and salivary-gland pain.


Propranolol and hypoglycemia.

Propranolol and hypoglycemia.


Immune reactions in polysaccharide media. 1. The effect of dextran on the reaction between iodine-125 labelled human serum albumin and gamma-G-globulin from rabbit anti-albumin sera.


Hemodynamic effects of isotonic solutions rapidly injected into the heart and great vessels.


A modified Golgi-Cox method with counterstain for the study of synapses.


Lipoprotein in the normal and regenerating limb tissues of the adult newt, Diemictylus viridescens.


Glycogen content of preimplantation mouse embryos.


Preparation and some properties of antibodies with specificity toward rho-nitrophenyl esters.


The effect of phenothiazines on cerebrospinal fluid.


The learning of double alternation by children and adults under different training procedures.


The motivational effect of value symbols and competition upon problem-solving behavior in children.


A diazosulfanilic acid azure A sequence for tissue protein.


Studies in histochemistry. LXXXV. Histochemical demonstration of protein with bromsulfalein.


Two methods for the demonstration of noradrenaline-containing adrenal medullary cells.


Rubrobulbar fibres to the facial nucleus and the lateral reticular nucleus (nucleus of the lateral funiculus). An experimental study in the cat with silver impregnation methods.


A milk-borne infectious hepatitis epidemic.


One-pill-a-month contraceptive.

One-pill-a-month contraceptive.


Regional distribution of some chemical structural components of the human nervous system. II. Cerebrosides, proteolipid proteins and residue proteins.


A newly defined X-linked trait in man with demonstration of the Lyon effect in carrier females.


Paternal immunoglobulin abnormalities in congenital hypogammaglobulinemia.


Gastrointestinal observations in rosacea.


Lymphocyte transformation in drug hypersensitivity.


Variations in the frequency and form of sex chromatin in females with burns.


Postoperative depression of the lymphocyte response to phytohaemagglutinin.


Narrow-bore suprapubic bladder drainage in Uganda.


Activity of lymphoid tissues from antilymphocyte-serum-treated mice.


Characteristics in youth predisposing to fatal stroke in later years.


Serum gamma-G-globulin levels and gestational age in premature babies.


Autoimmune reactions and virus-like particles in germ-free NZB mice.


Epidemic polyuria in man caused by a phycomycetous fungus (the Sassoon hospital syndrome).


Coonhound paralysis. An acute idiopathic polyradiculoneuritis in dogs resembling the Landry-Guillain-Barré syndrome.


Growth-rate in utero.

Growth-rate in utero.


Fasting serum-triglycerides concentration and distribution of subcutaneous fat.


What is value for money in medical care? Experiences in England and Wales, Sweden, and the U. S. A.


The difficult historian.

The difficult historian.


Lymphocytic activation by transfusion.

Lymphocytic activation by transfusion.


Warming emergency blood-transfusions.

Warming emergency blood-transfusions.


Efficient use of blood.

Efficient use of blood.


Isoniazid: how much a carcinogen?

Isoniazid: how much a carcinogen?


What is the nephrogram?

What is the nephrogram?


Oxygen by face mask and nasal catheter.

Oxygen by face mask and nasal catheter.


Propranolol in myocardial infarction.

Propranolol in myocardial infarction.


Treatment of alcohol dependency.

Treatment of alcohol dependency.


Rickets from liquid paraffin.

Rickets from liquid paraffin.


Benjamin William Rycroft.

Benjamin William Rycroft.


Induction of hepatic 7,12-dimethylbenz(alpha)anthracene metabolism by polycyclic aromatic hydrocarbons and aromatic azo derivatives.


A naturally occurring fragment related to the heavy chains of immunoglobulin G in normal human urine.


F'c fragment of immunoglobulins.

F'c fragment of immunoglobulins.


Use of charged thiol reagents in interpreting the electrophoretic patterns of immune globulin chains and fragments.


Transplantation immunity: localization in mouse serum of antibodies responsible for haemagglutination, cytotoxicity and enhancement.


Lack of natural tolerance to allotypic gamma-globulins in rabbits.


Staining of Paneth cells with thioflavine T.


Azure A-Schiff, alcian blue, HIO4-Schiff, Naphthol yellow S--a sequential staining method for paraffin sections.


Immunosuppressive therapy of chronic renal disease.


Application of methods for mammalian chromosome spreads to the cells of cestodes.


Staining of small lymphoid nucleoli in paraffin sections by aniline-azure B.


Staining and washing ultrathin sections; a device for handling various materials simultaneously.


Simplified culture and chromosome preparations of primate leukocytes.


Rapid schedules for KOH clearing and alizarin red S staining of fetal rat bone.


Staining rickettsiae in sections of formalin-fixed tissue; a 12-minute Wright-buffer sequence.


A rapid tissue-culture stain based on Heidenhain's iron-hematoxylin but requiring no differentiation.


Management of pain in cancer, with special reference to pain caused by pelvic malignancy.


Cytologic observations on the pancreatic islets with reference to some endocrine-like cells of the gastrointestinal mucosa.


Morphology of the mouse embryo, from the time of implantation to mesoderm formation.


Role of the forensic science laboratory.


Natural history and clinical significance of arrhythmias after acute cardiac infarction.


The relative proportions of IgG-, IgAand IgM-containing cells in rabbit tissues during experimental trichinosis.


The detection of monoclonal macroglobulinemia with antisera specific for gamma-M-globulins.


Allotypy of serum immunoglobulins in systemic and chronic lupus erythematosus.


Hypercalcaemia and supravalvar aortic stenosis.


No questions asked. . .?

No questions asked. . .?


Penicillin and working capacity.

Penicillin and working capacity.


The growth of mouse bone marrow cells in vitro.


The effect of anti-thyroid drugs on thyrocalcitonin secretion.


Autoantibodies in ulcerative colitis.

Autoantibodies in ulcerative colitis.


Electrochromatographic separation of low molecular weight Elson-Morgan and ninhydrin-positive substances obtained by gel filtration of urine.


Cytophysiology of the lead-hematoxylin positive cells in the hypophysis of the slender loris.


Comparison of three methods for the estimation of the conversion factor (ratio PB 131-I: total 131-I) in biological material.


Studies on the A1-cells in the endocrine pancreas of some cartilaginous fishes.


Dirofilariasis in Connecticut dogs.

Dirofilariasis in Connecticut dogs.


Perinuclear halo versus koilocytotic atypia.


Glycoprotein profiles of fetal and maternal serum.


Anemia of pregnancy treated with single intravenous dose of iron-dextran.


Metachromatic leukodystrophy (sulfatide lipidoses) cultured in vitro. Cerebral white matter from a patient with metachromatic leukodystrophly was successfully cultured in vitro. A luxuriant growth in Rose chambers and in roller tubes was apparent by the 14th day. The outgrown cells contained large numbers of granules which stained dark brown with cresyl violetacetic acid. The growth and metachromasia were maintained up to 80 days in vitro.


Thyroxine interaction with actinomycin D and possible biological implications. Actinomycin D and thyroxine interact in solution (pH 8 to 10), as revealed by changes in the absorbance of actinomycin D. Thyroxine can prevent the growth-inhibitory effect of actinomycin D on Bacillus subtilis if it is present in a molar ratio of 3000 (thyroxine to actinomycin D).


Toxicity of antibiotics in laboratory rodents.


On the metabolites of penicillium duclauxi delacroix--3. The reactions of duclauxin with ammonia and primary amines. The structures of desacetylduclauxin, neoclauxin, xenoclauxin and cryptoclauxin.


Biosynthesis of duclauxin.

Biosynthesis of duclauxin.


Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. With special reference to the permeability disorders of the nervous system's capillaries.


Congenital metachromatic leukodystrophy. Report of a case.


Experimental studies on the pathogenesis of leucodystrophies. II. The effect of sphingolipids on various cell types in cultures from the nervous system.


Separation of two trypsin-binding alpha-2-globulins of human serum.


Electrophoresis and immunoelectrophoresis of pericardiac fluid proteins.


Affinity of animal cell nucleoli for normal serum. Preliminary characterization of serum and cell components. Nucleoli of animal cells cultured in vitro are modified by a component of "nonimmune" animal serum. Modified nucleoli bind fluorescein-conjugated nonimmune serum proteins, as shown by calcium ion-dependent fluorescence. Analysis of serum indicates that the nucleolar-binding component is a globulin, with an electrophoretic mobility in the same region as the slow alpha-1 component in pH 8.6 Veronal buffer. The component has a low sedimentation constant (2.4S), and appears to contain glycoprotein with relatively high sialic acid content (8.5%); the latter moiety may be essential to reaction with nucleoli. The nucleolar component reacting with this alpha globulin fraction appears to be a histonelike basic protein. Primary cultures of animal cells have been supported for 1 wk through attachment, spreading, and outgrowth from colonies to confluent monolayers in medium containing a nucleolar-reactive serum fraction as the only protein supplement.


Phosphotungstic acid-hematoxylin, reactivity in vitro.


Microspectrophotometric analysis of basic protein rich sites stained with Biebrich scarlet.


Nephrotoxic serum nephritis in complement intact and deficient mice.


Histopathology of the larger colonic polyp.


Massive hemorrhage from colonic diverticula caused by arterial erosion: a practical theory of its mechanism and causation: report of two cases.


How effective is TV as a bedside teaching aid?


The hibernation cycle and related changes in the brown fat tissue of Citellus lateralis.


Electron microscopic observations on the substructure of tobacco rattle virus.


Note on the theory of symbolic transformations.


Molecular nature of the drug-resistance factors of the Enterobacteriaceae.


Rapid staining procedures for differentiating plant virus inclusions in epidermal strips.


Discrete gammaglobulin (M-)components in serum. Clinical study of 150 subjects without myelomatosis.


Reversible inactivation of an endotoxin by plasma proteins.


The inactivation of endotoxin after interaction with certain proteins of normal serum.


The histamine-sensitizing effect of endotoxins.


Role of antibodies in reactions to gram-negative bacterial endotoxins.


Protection against lethality of E. coli endotoxin with "O" antiserum.


Uric acid excretion following pelvic perfusion for malignancy.


Radioactive iodine, antithyroid drugs, and surgery in treatment of hyperthyroidism.


Fractionation on DEAE-Sephadeex of normal and a-myeloma human sera. I. Electrophoretic heterogeneity of gamma-a globulins.


Regulation of the initiation of hemoglobin synthesis in the blood island cells of chick embryos. 3. Qualitative studies of the effects of 8-azaguanine and preparations of transfer RNAs.


Dicumarol: a novel inhibitor of steroid 11-beta-hydroxylation.


Determination of chlorinated insecticides in human blood.


Evidence for in vivo breakdown of beta-10-globulin in hypocomplementemic glomerulonephritis. Evidence has been obtained for the presence in vivo of alpha(2D)-globulin, a breakdown product of serum beta(1C)-globulin, in patients with acute and persistent hypocomplementemic glomerulonephritis. The protein has been identified by immunoelectrophoretic analysis, and the amounts present have been determined by direct measurement of specific antigenic determinants present on alpha(2D). beta(1A)-Globulin, another breakdown product of beta(1C)-globulin, may also be present in vivo in severely hypocomplementemic patients, but its levels are much lower than those of alpha(2D)-globulin.Alpha(2D)-globulin has been identified by immunoelectrophoretic analysis of fresh EDTA plasma from patients with hypocomplementemic nephritis as an arc in the alpha(2) region that shows a reaction of identity with the arc representing alpha(2D)-globulin produced by aged normal serum. beta(1A)-Globulin was not seen in these patterns. Measurement of specific antigenic determinants has been carried out in both fresh EDTA plasma and aged serum. In the fresh plasma, the concentration of D antigen, found on both beta(1C)- and alpha(2D)-globulins, has been related to that of B antigen, found only on beta(1C) and taken as a measure of the concentration of this protein. In the hypocomplementemic patients, the concentration of D antigen, in comparison to that of B, was greater than in the normal subjects. Similarly, in aged serum, the level of alpha(2D) was greater than would be expected from the amount of beta(1C) that had been broken down in vitro, measured by the concentration of beta(1A). Calculations indicated that the in vivo alpha(2D) level in severely hypocomplementemic patients ranged from 7.5 to 18% of that which would be found in a pool of aged normal serum in which beta(1C) is completely broken down. The levels tended to be lower in less severely hypocomplementemic patients, and none could be detected in normal plasma. Only small quantities of A and D antigens are detectable in the urine of patients with hypocomplementemic nephritis. The rate of excretion is about equal to that of the normal subject. The study indicates that the low serum levels of beta(1C)-globulin that may be present over long periods in patients with persistent hypocomplementemic glomerulonephritis can be ascribed, in part, to in vivo breakdown of this protein as a result of reaction with immune complexes. The contribution of beta(1C) deposition on immune complexes and of diminished synthesis to the depressed serum levels cannot be assessed by the present study.


Immunopathologic studies of systemic lupus erythematosus (SLE). I. Tissue-bound immunoglobulins in relation to serum antinuclear immunoglobulins in systemic lupus and in chronic liver disease with LE cell factor. We studied the composition of tissue-bound immunoglobulins and of antinuclear factors by immunofluorescent techniques in five patients with systemic lupus and two with chronic liver disease associated with positive LE cell tests. Renal glomeruli in all seven demonstrated deposits of bound gammaG-globulin and complement, although the presence of gammaA- and gammaM-immunoglobulins was variable. Blood vessel walls contained primarily gammaG-globulin and complement in the systemic lupus patients, but such deposits were absent from vessels in the two with chronic liver disease. We observed antinuclear factors, demonstrated by immunofluorescence, in all three immunoglobulin classes. In six of the seven patients, evidence was obtained of a correspondence between the classes of bound immunoglobulins in glomeruli and vessels and the serum titers of antinuclear immunoglobulins. These observations are consistent with the concept that immunoglobulin deposits in tissues may be derived at least in part from antinuclear factors. Neither bound immunoglobulins nor complement was observed in liver parenchyma of the two patients with chronic liver disease or in two patients with systemic lupus and liver pathology. It thus seems doubtful that serum antibodies play a primary role in the pathogenesis of forms of chronic liver disease associated with positive LE cell tests.


Districts, Pennsylvania Dental Association.


Stainless steel crowns.

Stainless steel crowns.


Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. The gammaG-globulin eluted at acid pH from kidney cortex homogenates and isolated glomeruli of five of six patients with lupus nephritis was found to exhibit antinuclear activity, which was not dependent on presence of fresh human serum. Specificity, as demonstrated by absorption of antinuclear activity, was related to nucleoprotein in three glomerular acid eluates and to DNA in two acid eluates as well as in a deoxyribonuclease digest of disrupted glomeruli in one patient. Antinuclear activity was not found in acid eluates of kidneys from two patients with chronic liver disease and chronic discoid lupus, respectively, and one with lupus nephritis. These patients had a low titer of serum antinuclear factor and lesser amounts of kidney bound immunoglobulins. The presence of antinuclear activity in eluates of kidneys appeared to correlate with the amount of glomerular bound immunoglobulin and the level of antinuclear antibodies in serum. These findings suggest that in lupus nephritis, part of the glomerular bound immunoglobulin is derived from serum antinuclear factors possibly deposited as immune complexes.


Advantages of mixed dentition treatment.


The handicapped dental patient.

The handicapped dental patient.


Vital staining of Histoplasma capsulatum with Janus Green B.


The morphologic and physiologic basis for a new classification of lymphoedema.


Lupoid features in a case of leprosy.

Lupoid features in a case of leprosy.


Experimental arteriosclerosis in dogs: the effects of triton-induced hyperlipemia.


Phenobarbitone and the shoulder-hand syndrome.


Protein-bound iodine determination by activation analysis.


Electrophoretic studies of sera from cattle vaccinated or naturally infected with Brucella abortus. Examinations of the electrophoretic behaviour in cellulose acetate were made on the proteins of sera from 18 field cases of brucellosis, 15 calves recently vaccinated with strain 19 Brucella abortus and from 28 normal cattle. The total protein and gamma-globulin content of the sera of the naturally infected, serologically positive cattle tended to be somewhat higher than that of sera from most normal cattle. A few of the serologically-negative normals also had defenitely elevated serum gamma-globulin values. In the vaccinated calves there was an increase both in total serum protein and gamma-globulin but its magnitude in different individuals was not directly related to the rise in their antibody titre.


A mumps epidemic on St. George Island, Alaska.


Preparation of permanent whole mounts of marine centric diatoms to permit observations of cytoplasmic inclusions.


The physiological role of the lymphoid system. I. An extension of the mechanism of antibody-antigen reaction.


Infiltrating and embedding tissues with mixtures of polyethylene glycols and polyvinylacetate resins.


Bird erythrocytes in experimentally introduced blood clots, for differentiation from autogenous mammalian clots.


A microspectrophotometric analysis of staining with carmine, orcein and carmine-orcein.


Polychromasia of cresyl violet dyes; a chemical explanation of variations in pre-World War II products.


Histochemical analysis of microdissected nephrons: enzyme stains.


A basic fuchsin-alcian blue stain for the human hypophysis.


Controlled-heat fixation of smears and thin tissue slices in liquid mercury.


A general stain based on Gallego's method for connective tissue.


Lipid-protein interrelationship in pregnancy.


The histochemical localization of calcium in the keratohyalin granules of human oral epithelium.


Iodine metabolism in young chinook salmon (Oncorhynchus tschawytscha, Walbaum). I. Thyroidal impairment with the use of 131-I.


Effect of EDTA on histochemical demonstration of phosphorylase activity.


Electron microscope studies of antigen-antibody complexes.


Reticulocytosis in renal failure.

Reticulocytosis in renal failure.


Segmental infarcts of the small intestine and mesenteric adenitis in Thai children.


Maternal serum-proteins in idiopathic respiratory distress syndrome of the newborn.


Glucose tolerance, age, and circulating insulin.


Trophoneurotic blisters in elderly hemiplegics.


Diagnosis of posterior urethral inflammation in the male.


Absence of harmful effect of maternal hypocapnia in babies delivered at caesarean section.


Hydrocortisone-production rates in Africans.


Venous distension in strangulated femoral hernia.


Measurement of glomerular filtration-rate in man using a 51Cr-edetic-acid complex.


Enhancement by caffeine of glucagon-induced and tolbutamide-induced insulin release from isolated foetal pancreatic tissue.


Cells in human spleen forming antibody to sheep erythrocytes.


A transmission model for kuru.

A transmission model for kuru.


Oral contraceptives and thromboembolism.


The advance of cholera.

The advance of cholera.


Antibody, antimind?

Antibody, antimind?


An ABC of modern immunology. I. Links between the old and the new.


Viral hepatitis. A staff hazard in dialysis units.


Pneumococcus resistant to erythromycin and lincomycin.


Fatal granulomatous disease of childhood.


Efficient use of blood.

Efficient use of blood.


Octanoic acid and free fatty acids.

Octanoic acid and free fatty acids.


Chromosome anomalies.

Chromosome anomalies.


Frusemide in acute pulmonary oedema.

Frusemide in acute pulmonary oedema.


Adult coeliac disease and neuropathy.

Adult coeliac disease and neuropathy.


Sickle-cell anaemia in G.-6-P.D. deficiency.


Merokinetic effect of Anovlar.

Merokinetic effect of Anovlar.


Thyroxine and hypolipidaemic effect of clofibrate.


Efect of "Dicumarol" (bishydroxycoumarin) on insulin secretion in vitro.


Modified vesicourethroplasty for the contracted vesical neck. Technic and clinical results.


On the origin of lactic dehydrogenase isoenzymes in urine.


Specificity of the antiglobulin test in "auto-immune" hemolytic anemias.


A possible genetic basis for specific pattern in antibody.


In vitro absorption of gamma-globulin by neonatal intestinal epithelium of the pig. 1. An in vitro method, using fluorescent gamma-globulin and everted neonatal pig's intestinal slices, for the study of the active transport of large molecules is described.2. Uptake of gamma-globulin occurred within 15 min and required no exogenous substrates.3. In vitro absorption of gamma-globulin by intestinal epithelium was limited to the neonatal pig and 5-day-old mouse. No uptake was seen in intestines from a mature mouse, a pig with diarrhoea, a normal pig, a mature rabbit, a guinea-pig, a chick, and a chick embryo. Chick embryo yolk sac readily took up gamma-globulin.4. Rings of everted intestinal epithelium remained active (still absorbed gamma-globulin) after incubating for 4-6 hr in balanced salt solution (BSS).5. Uptake of gamma-globulin required oxygen and sodium and was reversibly inhibited by metabolic antagonists such as iodoacetate, arsenate, fluoride, 4,6-dinitro-varphi-cresol, phlorrhizin, anaerobiosis and cold. Under the conditions of the test, large colloidal molecules did not inhibit uptake of gamma-globulin.6. Similar results (although not as clear-cut) with metabolic inhibitors were obtained with preparations of chick embryo yolk sacs.7. Injuring mature pig's intestinal epithelium with surface-active agents did not produce non-specific absorption artifacts that resembled the specific absorption found in immature pig's intestinal epithelium.


Structural heterogeneity of L chains in antibodies of restricted specificity.


Medical services under TITLE XIX.

Medical services under TITLE XIX.


Flaps and flap necrosis. Improving the circulation in skin flaps with Complamin and with Dicoumarol: animal experiments.


Application of an in vitro cariogenic technic to study the development of carious lesions around dental restorations.


Hyperplasia, atypism, and carcinoma in situ in prostatic periurethral glands.


Variations in argentaffin cells in experimental gastritis.


Bifunctional imidoesters as cross-linking reagents.


Fluoride levels of plasma and cerebrospinal fluid.


Reversal of azide inhibition by uncouplers.


Antinuclear antibodies and nuclear antigens. The lupus erythematosus (LE) cell factor is one of a variety of heterogeneous antibodies directed against many nuclear antigens. These antinuclear antibodies are found in a wide variety of clinical disorders. As detected by immunofluorescence techniques, they are so frequently found in association with systemic lupus erythematosus that their absence essentially excludes that diagnosis. It is suggested that in certain situations other than systemic lupus, antinuclear antibodies may be the result of some inflammatory and destructive processes. Antinuclear antibodies may be detected in certain lower animals frequently in association with disease. In lower animals, immunization with nuclear antigens appropriately complexed* to protein carriers consistently results in the induction of antinuclear antibodies. In both man and animals, antinuclear antibodies are often detected without associated disease. Furthermore, antinuclear antibodies are not injurious to intact tissue culture cells. Nonetheless, antigen-antibody complexes consisting of nuclear antigens and antinuclear antibodies may contribute to the propagation of certain diseases, particularly lupus nephritis. The use of antinuclear antibodies as immunochemical tools holds great promise for the better understanding of such nuclear antigens as are found in viruses and in the nuclei of certain malignant cells.


Effect of progestational agents on gonadal and adrenal cortical function in patients with benign prostatic hypertrophy and carcinoma of the prostate.


Nucleolar architecture in root meristematic cells of Allium cepa.


Morphological observations on the nucleolus of cells in tissue culture, with special regard to its composition.


Nucleolar-chromosomal interaction in microspores of maize.


Synthesis of transfer RNA in the nucleolus of Smittia.


Autoradiographic, biochemiical, and ultrastructural studies into the effect of actinomycin, 5-fluorouracil, and adenosine on nucleolar and cellular structure and function.


RNA metabolism in the HeLa cell nucleus and nucleolus.


The nucleolus and ribosomal RNA synthesis in mammalian cells.


Histologic studies of human coronal dentine following cavity preparations and exposure of ground facets in vivo.


Homogenous deposits in the membranous semicircular canals.


Antibody purification on insoluble adsorbents and purification and characterization of immunoglobulin A. A meeting, sponsored by WHO, was held at the WHO International Reference Centre for Immunoglobulins in Lausanne, Switzerland, from 12 to 17 March 1966 to review (a) antibody purification on insoluble adsorbents and (b) immunoglobulin A (IgA, gammaA) purification and characterization.The text below-prepared by Dr J. L. Fahey, Dr E. C. Franklin, Dr R. S. Nezlin and Dr T. Webb-is a précis of some of the statements made at this meeting.(a)


The effect of phytohaemagglutinin on the metabolism and  gamma-globulin synthesis of human lymphocytes.


Effect of experimental allergic encephalomyelitis gamma-globulin upon the electrical activity of the brain.


Effect of menadione on the phagocytic activity of guinea-pig polymorphonuclear leucocytes.


Purification of ferritin-labelled immunoglobulins.


Comment on Dr Ritvo's paper.

Comment on Dr Ritvo's paper.


The adaptive use of regression.

The adaptive use of regression.


Pathogenesis of the renal lesion associated with the abuse of analgesics.


Maternal and foetal ketone concentrations in plasma and urine.


Influence of hyperbaric oxygen on the survival of split skin grafts.


Probable gallbladder infection in convalescent cholera patients.


The iliofemoral venous segment as a source of pulmonary emboli.


Hydrocephalus due to elongated basilar artery. A new clinicoradiological syndrome.


Cerebral blood flow in subarachnoid hemorrhage.


Tyrosine metabolism and faecal aminoacids in cystic fibrosis of the pancreas.


The possibility of predicting the efficacy of cancer chemotherapy in the prolongation of survival.


Simple warning system for apnoea in premature infants.


Design of operating-theatres.

Design of operating-theatres.


Myocarditis.

Myocarditis.


Polymyositis.

Polymyositis.


Breast cancer.

Breast cancer.


Iliofemoral thrombosis.

Iliofemoral thrombosis.


Tetanus in Britain.

Tetanus in Britain.


Student health in Oxford.

Student health in Oxford.


Renal stones and sodium.

Renal stones and sodium.


II. Antibodies anatomised.

II. Antibodies anatomised.


Planning for community health.

Planning for community health.


Efficient use of blood.

Efficient use of blood.


Guillain-Barré syndrome complicating mumps.


Neurotoxic side-effects of piperazine.

Neurotoxic side-effects of piperazine.


Jaundice from potassium p-aminobenzoate.


Fibroblast chromosome preparations.

Fibroblast chromosome preparations.


Systematic desensitisation for phobias.

Systematic desensitisation for phobias.


Classifying protein-calorie malnutrition.


Oral contraceptives and thromboembolism.


Skin reactions to phytohaemagglutinin.

Skin reactions to phytohaemagglutinin.


Acetylcysteine in airway maintenance.

Acetylcysteine in airway maintenance.


Hypersensitisation by measles virus.

Hypersensitisation by measles virus.


Pregnancy tests and proteinuria.

Pregnancy tests and proteinuria.


Systemic effects of skin disease.

Systemic effects of skin disease.


Pontine gliomas of childhood.

Pontine gliomas of childhood.


Clinical and pathological significance of asymptomatic atrophic thyroiditis. A condition of latent hypothyroidism.


Renal haemodialysis in porphyria.

Renal haemodialysis in porphyria.


Iodide goitre.

Iodide goitre.


Change in gastric iron-binding protein (gastroferrin) during iron-deficiency anaemia.


Phenylalanine-hydroxylase activity in hyperphenylalaninaemia.


Heterograft aortic-valve replacement.

Heterograft aortic-valve replacement.


Radiocalcium turnover in man.

Radiocalcium turnover in man.


Design of outpatient departments.

Design of outpatient departments.


The grey bar.

The grey bar.


The nature of pain.

The nature of pain.


Propranolol.

Propranolol.


Wound repair: sutures or strips?

Wound repair: sutures or strips?


A telluric disease.

A telluric disease.


3. Immunoglobulin physiology.

3. Immunoglobulin physiology.


Community medicine.

Community medicine.


Heat as the cause of dental decay.

Heat as the cause of dental decay.


Heterogeneity of heavy (gamma) chain preparations from human gamma G-immunoglobulins.


Foreign body reaction of the brain. Enzyme-histochemical study in dogs.


Keratomycosis: an ultrastructural study.


Ruby laser micro-irradiation of single tissue culture cells vitally stained with Janus green B. I. Effects observed with the phase-contrast microscope.


Fluorescent probes for conformational states of proteins. I. Mechanism of fluorescence of 2-p-toluidinylnaphthalene-6-sulfonate, a hydrophobic probe.


Effect of papain digested, univalent antibody on the morphology, cleavage and fertilizing capacity of sea urchin eggs.


A comparison of neutralizing antibodies to rubella virus in gamma globulin and "convalescent" sera.


Congenital rubella syndrome in late infancy.


Experimental studies on the pathogenesis of leucodystrophies. I. The effect of intracerebrally injected sphingolipids in the rat's brain.


Failure to detect 3,4-dimethoxyphenylethylamine in the urine of psychotic children.


Plasma growth hormone after arginine infusion. Clinical experiences.


Characterization of the antibody response to acetone-killed typhoid vaccine.


Some effects of clofibrate in hypothyroidism and on the metabolism of thyroxine.


A filter method for processing small samples of marine ova through fixation, dehydration, and embedding without changing containers.


Fact sheet on dental prepayment.

Fact sheet on dental prepayment.


Establishing occlusal vertical dimension in edentulous patients.


Dental care for homebound patients in Philadelphia.


Chromosomal aberrations common to three types of monoclonal gammopathies.


Treatment by prostatic injection of acute urinary retention due to prostatic hyperplasia.


The localization and distribution of protein-bound sulfhydryl and sisulfide groups in skeletal tissues of mice during growth and aging.


Thyroid hormone secretion by the fetal thyroid gland.


Isolation and characterization of Lafora bodies in two cases of myoclonus epilepsy.


A chemical basis for the staining of myelin sheaths by luxol dye techniques; further observations.


Transformation of astrocytes and destruction of spongioblasts induced by a simian tumor virus (SV40) in cultures of human fetal neuroglia.


Immunohistochemical studies in diabetic glomerulosclerosis.


The phases of muscle necrosis.

The phases of muscle necrosis.


Thymic dysplasia ("Swiss agammaglobulinemia"). I. Graft versus host reaction following bone-marrow transfusion.


Immunoglobulins and other proteins in commercial preparations of gamma globulin.


Actinomycin D in management of Wilms' tumor.


Distribution in human nasopharyngeal tonsils of plasma cells containing different types of immunoglobulin polypeptide chains.


A light and electron microscopic study of the effects of a single dose of cyclophosphamide on various organs in the rat. I. The urinary bladder.


Human renal ultrastructure. II. The thin limb of Henle's loop and the interstitium in healthy individuals.


Bile ductules in cholestasis: morphologic evidence for secretion and absorption in man.


Influence of pregnancy and oral contraception on the incidence of strokes in women of childbearing age.


Intravenous glucose-tolerance test in parents of diabetic children.


Vasomotor-relfex response in idiopathic and hormone-dependent migraine.


Influence of environmental factors on foetal growth in man.


The effect of retinol (vitamin-A alcohol) on urinary excretion of mucopolysaccharides in the Hurler syndrome.


Iron distribution in the liver of patients with thalassaemia major.


Relief of pain in labour.

Relief of pain in labour.


Cerebral-cortex-perfusion rates in migraine.


Accidental hypothermia treated by extracorporeal blood warming.


Automatic equilibration of volume in exchange transfusion in adults.


Oral contraceptives and thromboembolism.


Autoimmunity in idiopathic addison's disease.


Alcohol shift.

Alcohol shift.


Coagulation--fibrinolysis.

Coagulation--fibrinolysis.


Paddy-field foot.

Paddy-field foot.


Mycoplasmas.

Mycoplasmas.


Is the anesthetic really necessary?

Is the anesthetic really necessary?


Some practical aspects of intensive cytotoxic therapy.


An ABC of modern immunology. V. The immunological capability of small lymphocytes.


Kissing as a mode of transmission of infectious mononucleosis.


Incorporation of labeled amino acids into serum and tissue proteins from normal and x-irradiated mice.


131-I-tobacco mosaic virus inhibition of hemolysin formation in rabbits.


Molecular weight of renin determined by Sephadex G-200 gelfiltration.


A general program for maximum likelihood estimation of gene frequencies.


Granular dystrophy of the cornea. A histochemical and electron microscopic study.


Quantitative immunoglobulin levels (IgG, IgA and IgM) in children with intractable asthma.


Fine structural demonstration of acid phosphatase activity in Auer bodies.


Cytophotometric determination of nucleic acids in UV-light and after gallocyanine chromalum staining.


Ruby laser micro-irradiation of single tissue culture cells vitally stained with Janus green B. 3. Effects on the incorporation of an RNA pyrimidine precursor.


Nucleolar change produced by mithramycin in rat hepatic cell.


Progress in dental education.

Progress in dental education.


A technique for installing new stimuli in Grason-Stadler in-line readout projectors.


Carcinoma in a pharyngoesophageal diverticulum.


The current status of chemotherapy for advanced renal carcinoma.


Inappropriate secretion of antidiuretic hormone in urologic patients.


Tetanus immune globulin from selected human plasmas. Six years of experience with a screening method.


Third national conference on air pollution.


The expanded congenital rubella syndrome: report of two cases with neonatal purpura and review of the recent literature.


Some features of the vascularization of the carotid body in the dog.


Some histochemical reactions for lipids in avian nervous tissues. II. Peripheral nervous tissues.


Cytochemistry of a lysosomal enzyme in malignant cells of primary and secondary tumours.


Cybernetic foundations for rehabilitation.


Serum protein turnover in the congenital nephrotic syndrome. Experimental studies with 3H-tyrosine and 131-I-proteins.


D-myeloma. Report of two cases.

D-myeloma. Report of two cases.


IgG paraproteinemia associated with bronchogenic carcinoma.


Experimental obstruction of the periodontal blood circulation.


A polarized light microscopic study of rat periodontal ligament following surgical and chemical gingival trauma.


Diffusion kinetics of injected foreign protein from the cornea: correction.


Effect of electron stains and desmosome; an electron microscopic study.


Non-collagenous proteins of human dermis.


Assay of the anti-oestrogenic effects of progestagens in women.


A study of the early stages of implantation in mice.


A direct measurement of the sex-ratio in mouse blastocysts.


Syncytial proliferation in normal and toxemic pregnancies.


Comparative electron microscopy of the placental junctional zone.


Examination of virus-gamma-M antibody complexes by electron microscopy. I. Configuration of gamma-M antibodies and mode of attachment to antigen.


The relationship between penetration and uncoating of poliovirus in HeLa cells.


Iodide metabolism in Ontario.

Iodide metabolism in Ontario.


Endemic goiter in Pedregoso (Chile). 1. Description and function studies.


Clinical manifestations of postnatal and congenital rubella.


Ataxia-telangiectasia. Report of seven cases.


The innervation of chronic inflammatory human periapical lesions.


Gross aortic sudanophilia and hemosiderin deposition. A study on infants, children, and young adults.


Study of human renal disease by immunofluorescent methods.


Extracellular bound lipid in developing connective tissue.


Effect of dietary protein level and thyroxine on vitamin A absorption and on plasma proteins in chicks.


Synthesis of the heterocyclic compounds by Pschorr cyclization. 3. Syntheses of 10,11-methylenedioxy-7,8-dihydro-6H-benzol[c]pyrid-[1,2-a]azepinium salts and their derivatives.


Retinofugal projections of Caiman sklerops.


Synaptic loci on visual cortical neurons of the rabbit: the specific afferent radiation.


Electrophoretic analysis of polypeptide chains isolated from antibodies in the serum of immunized rabbits.


Neutralizing and hemagglutination-inhibiting activity of nasal secretions following experimental human infection with A2 influenza virus.


Immunoglobulins of the rhesus monkey (Macaca mulatta). I. Antiserum to bovine serum albumin and the dinitrophenyl antigenic determinant.


Studies on rabbit lymphocytes in vitro. VII. The induction of blast transformation with the F(ab')2 and F ab fragments of sheep antibody to rabbit IgG.


The use of the preparative ultracentrifuge to detect primary interactions between I-131-labeled antigen and antibody.


Duck immunoglobulins. I. Structural studies on a 5.7S and 7.8S gamma-globulin.


Duck immunoglobulins. II. Biologic and immunochemical studies.


The X-Y-Z scheme of immunocyte maturation. 3. Early IgM memory and the nature of the memory cell.


Uptake by mononuclear phagocytes of protein-coated bentonite particles stabilized with a carbodiimide.


An alteration of secreted immunoglobulin in serum.


The role of lymphatics in renal transplantation. Renal lymphatic regeneration.


Thyroid hormone and calcium metabolism.

Thyroid hormone and calcium metabolism.


Gastric function in gastric carcinoma.

Gastric function in gastric carcinoma.


Selective immunoglobulin deficiency associated with thymic alymphoplasia.


Catabolism of serum proteins after x-irradiation.


Association between hypothyroidism and myasthenia gravis and a concept of generalized systemic auto-immunopathy.


Some aspects of radiotherapy of abdominal tumors.


Management of primary carcinoma of the ovary.


Management of adenocarcinoma of the endometrium.


The management of metastatic disease in the skeletal system.


New methods of palliation of neoplastic obstructive jaundice.


Multiple myeloma and the nephrotic syndrome. A biochemical and morphologic study.


Thioflavin-T for amyloid detection.

Thioflavin-T for amyloid detection.


Comparison of use of alcohol with that of iodine for skin antisepsis in obtaining blood cultures.


Two myeloma globulins (IgG and IgA) in one subject and one cell line.


The importance of PBI-131 in metastases of thyroid cancer.


Immunologic studies in lichen myxedematosus.


Technique for estimating turnover time of human stratum corneum.


The acid hematein stain and myocardial damage.


Stain for differentiation and quantitation of gross lesions of atherosclerosis.


Serum glycoproteins in experimental scurvy and carageenan granuloma.


Alterations in plasma proteins in experimental amyloidosis.