Determination of salicylazosulphapyridine in biological materials.


Personality disorder and reactive hypoglycemia. A quantitative study.


Function of peroxidase and NADPH cytochrome C reductase during the Wolff-Chaikoff effect.


Role of phenothiazine compounds in the prevention of experimental pulmonary oedema.


Structure of deoxyribonucleic acid on the cell surface during uptake by pneumococcus. We exposed competent cells of Diplococcus pneumoniae to high-molecular-weight donor deoxyribonucleate (DNA) and examined the state of the DNA bound to them in forms sensitive to deoxyribonuclease I. The portion elutable with 5 M guanidine hydrochloride was shown to be native, of much lower molecular weight (4 x 10(6) to 5 x 10(6)) than the donor, and as active in further transformation as sheared DNA of the same size. The portion resistant to release by guanidine hydrochloride was also shown to be native and active in transformation. These results, along with previous ones, imply that the breaks produced outside the cell are not at genetically specific sites. Furthermore, it was found that entry past the cell barrier to deoxyribonuclease could occur at 0 C by a process sensitive to ethylenediaminetetraacetate.


Effects of hycanthone and two of its chlorinated analogs on hepatic microsomes.


tyrR, a regulatory gene of tyrosine biosynthesis in Salmonella typhimurium. 4-Fluorophenylalanine-resistant mutants of Salmonella typhimurium were isolated in which tyrosine pathway enzymes were not repressed by l-tyrosine. The mutants produced elevated levels of 3-deoxy-d-arabinoheptulosonic acid 7-phosphate (DAHP) synthetase (tyr) and chorismate mutase T-prephenate dehydrogenase, and these enzymes as well as transaminase A were not repressed by high concentrations of tyrosine. Genetic analysis revealed that a mutation in a gene designated tyrR was responsible for the constitutivity of the tyrosine pathway enzymes in strains SG1, SG7, and SG9, and that tyrR was linked to pyrF. In strain SG1 a mutation had also occurred in aroF, the structural gene for DAHP synthetase (tyr), resulting in loss of sensitivity of this enzyme to end-product inhibition. There appeared to be no relationship between loss of feedback inhibition and loss of end-product repression, since derivative strains of SG1 that carried only the tyrR mutation behaved like the singly mutated tyrR strains, SG7 and SG9, in showing high constitutive levels of tyrosine-specific enzymes that were not repressed by tyrosine.


The bronchodilator and cardiac stimulant effects of Thll65a, salbutamol and isoproterenol.


Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs.


Present status of treatment of chronic cor pulmonale with congestive failure.


Hemodynamic characteristics of the centrally mediated pressor activities of angiotensin.


Thymus-dependent functions of mouse thymocyte-fibroblast hybrid cells.


Control of growth hormone secretion in man.


An antihistamine-sympathomimetic amine combination in vasomotor rhinitis.


Reports from the general practitioner research group. Antihistamine and phenothiazine compared in vertigo.


MMPI changes for a male alcoholic state hospital population--1959 to 1971.


Observations on the ontogeny of the feeding response to   adrenergic agonists and antagonists.


Judged frequency of endorsement and frequency of occurrence scale values and dispersions for MMPI items.


The abortive lives of modern inhalation anesthetics.


Modified erythrocyte cation permeability.


Predictable variability in the response of two newt subspecies (D. v. viridescens and D. v. dorsalis) to first-set allografts.


Differentiation of receptors activated by catecholamines. 3.


Relationship between proliferative and effector phases of the mixed lymphocyte reaction and graft-vs-host reaction.


Congenital defects in Finnish calves.

Congenital defects in Finnish calves.


Changes in hepatic free NAD and NADP levels in rats fed a hypercholesterolaemic diet.


The immunosuppressive activity of ara-C (cytarabine) and derivatives.


Immunosuppressive enzymes.

Immunosuppressive enzymes.


Human peripheral lymphocytes and long-term cultured lymphoblastoid cells in local graft-versus-host reaction.


Bone marrow transplantation in immunosuppressed or congenitally immune deficient patients.


Graft versus leukemia. 3. Apparent independent anthost and antileukemia activity of transplanted immunocompetent cells.


Graft-versus-host-induced immunosuppression. The effect of antigenic stimulation on cell-mediated and humoral immune responses.


Glutamate dehydrogenases in Neisseria meningitidis.


Glutamate dehydrogenases in genus Neisseria.


Fluroxene and animal toxicity studies.

Fluroxene and animal toxicity studies.


Action of catecholamines and anti-adrenergic drugs on isolated short-circuited frog skin.


Action of serotonin on gastric (proventriculus) secretion in chickens.


The role of catecholamines and 5-hydroxytryptamine on the heart of Patella vulgata.


Catecholamines in arthropods: a review.

Catecholamines in arthropods: a review.


Specificity of feeding chemoreceptors in Palythoa psammophilia (Zoanthidea, Coelenterata).


Metabolism of N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlorphenamidine) and 4'-chloro-o-formotoluidide by rat hepatic microsomal and soluble enzymes.


Neurohumoral regulation and the pharmacology of a molluscan heart.


Dopamine receptors: a review.

Dopamine receptors: a review.


Histamine and histamine-like substances in the marine sponge, Suberites inconstans.


World neurosurgery: a personal history of a surgical specialty.


The reflection of ejecting and retaining currents in the time-course of neuronal responses to microelectrophoretically applied drugs.


The effects of changes in ionic environment and modification of adrenergic function on the vascular responses to sympathomimetic amines.


The ganglion blocking and vagolytic actions of three short-acting neuromuscular blocking drugs in the cat.


The effect of corticosterone on extraneuronal amine uptake and effector response in rat salivary glands.


Spectrophotofluorometric and gas-liquid chromatographic methods for the estimation of mexiletine (Kö 1173) in plasma and urine.


Interactions between oxotremorine and inhibitors of cholinesterase enzymes.


Quantitation of  1-tetrahydrocannabinol in plasma from cannabis smokers.


The recovery of bacteria from white soft paraffin.


Alkaloids from the seeds of Strychnos wallichiana Steud. ex DC. (Strychnos cinnamomifolia Thwaites var. wightii A. W. Hill).


Total and free-plasma tryptophan concentrations in rheumatoid disease.


The role of norfenfluramine in fenfluramine-induced mydriasis.


MAO-inhibitory properties of anorectic drugs.


Uptake of (3H)5-hydroxytryptamine and (3H)noradrenaline by slices of rat brain incubated in plasma from patients treated with chlorimipramine, imipramine or amitroptyline.


Depression of ganglionic transmission by normetadrenaline.


Further evidence in support of a common adrenergic mechanism for the facilitatory action on learning of amphetamine and nicotine in rats.


Restoration of morphine analgesia in morphine-tolerant rats after the intraventricular administration of 6-hydroxydopamine.


Effects of ethanol on cerebral cortical neurons: interactions with some putative transmitters.


Dopamine-induced relaxation of isolated arterial strips.


Effects of diethyldithiocarbamate and ethanol on the in vivo metabolism and pharmacokinetics of amphetamine in the rat.


Deacetylation of acetyl sulphapyridine in man.


Subtalar dislocation of the foot.

Subtalar dislocation of the foot.


Treatment of exercise-induced dysrhythmias in patients with pacemakers.


Diminished in vitro toxic effect of phytohaemagglutinin for lymphocytes of rats bearing syngeneic tumours.


Activity of reticuloendothelial system in methylcholanthrene-induced and transplanted tumour-bearing rats.


Superinfections in the antibiotic era.

Superinfections in the antibiotic era.


Unusual manifestations of periarteritis nodosa.


Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness.


The induction of a carcinogen-metabolizing enzyme in human skin.


A kinetic study of  -acetohydroxy acid isomeroreductase from Salmonella typhimurium.


The effect of o-diphenols upon the microsomal NADPH and NADH oxidase activities.


A microsomal fatty acid synthetase coupled to acyl-CoA reductase in Euglena gracilis.


Caries experience relative to individual susceptibility.


Fluoride in the prevention of dental caries. A tentative cost-benefit analysis.


Regular dental care in dentate persons. An assessment.


Excitatory and inhibitory innervation of the urinary bladder and gonads of a teleost, Gadus morhua.


Neurological involvement in the Smith-Lemli-Opitz syndrome: clinical and neuropathological findings.


Effects of reserpine on nervous control of heart-rate in chickens (Gallus domesticus).


Lipid peroxidation of rat-liver microsomes. Its effect on the microsomal membrane and some membrane-bound microsomal enzymes.


Heterogeneity of NADPH-dependent aldehyde reductase from human and rat brain.


Reduced pyridine-nucleotides balance in glucose-growing Saccharomyces cerevisiae.


Effect of dimethylaminoethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice.


Enzymatic hydroxylation of anthranilamide in rat liver.


Lack of immediate response of liver thyrosine-alpha-ketoglutarate transaminase to exogenous adrenaline in the adrenalectomized rat.


Mitochondrial NAD-dependent malic enzyme: a new regulatory enzyme.


Collagen heterografts for bone replacement. A preliminary report.


The influence of antistine on glycogenolytic effect of some biogenic amines in rat brain slices.


Salt activity and osmotic pressure in connective tissue. I. A study of solutions of dextran sulphate as a model system.


Transmitter release induced by injection of calcium ions into nerve terminals.


Inhibition of prostaglandin induced uterine activity in the second trimester of pregnancy by beta-mimetic adrenergic agents. Clinical research was undertaken to study the effect of 2 beta-mimetic adrenergic agents, orciprenaline and ritodrine, on uterine activity produced by administration of PGF2alpha (prostaglandin) in the 2nd trimester of pregnancy.  Subjects were 8 women admitted to the University Hospital in Uppsala, Sweden, for a therapeutic abortion in the 16h-24th week of pregnancy.  4 were given orciprenaline extraamniotically and 4 were given ritodrine intraamniotically.  Infusion of both the substances caused a decline in the frequency and intensity of uterine activity, which had previously been induced by administration of PGF2alpha.  For both drugs, the reduction in uterine activity was dose-related.  Both drugs caused an increased maternal heart rate.  Ritodrine also produced a rise in systolic and a fall in diastolic pressure.  No other side effects were observed.  Discontinuation of the drug infusion caused uterine activity to increase.  Results of the study demonstrate that beta-mimetic adrenergic agents are capable of inhibiting PG effects on uterine activity.  To achieve a significant reduction, however, the dose must be large enough to cause tachycardia and palpitation, side effects tolerated well by the patients.


N-of-one and N-of-two research in psychotherapy.


Repression-sensitization: a critique of some neglected variables in the literature.


Preparation of prostaglandins A2, E2 and 11-epi-E2 from their 15 acetates methyl esters using an endogenous enzyme system present in Plexaura homomalla (esper).


Studies on the mechanism underlying the enchanced noradrenaline-overflow from the rabbit heart induced by the beta-adrenolytic drugs bupranolol and pindolol.


Drug-induced hemolysis.

Drug-induced hemolysis.


Prescribing for patients with depression, anxiety and insomnia.


Alterations of cardiac sympathetic neurotransmitter activity in congestive heart failure.


Histochemical study of so-called "marker enzymes of cholestasis" during extrahepatic bile duct obstruction in the rat.


Gravlee Jet Washer effectiveness as performed by obstetric-gynecologic paramedical personnel.


Management of severe hypertension.

Management of severe hypertension.


Digitoxigenin metabolism by rat liver microsomes and its induction by phenobarbital.


Interaction of drugs and steroids with human placental microsomes.


Role of L-ascorbic acid on detoxification of histamine.


Comparison of two cardioselective beta-adrenergic blocking agents: effects on haemodynamic and atrioventricular conduction in man.


Effects of colicin A and staphylococcin 1580 on amino acid uptake into membrane vesicles of Escherichia coli and staphylococcus aureus.


Orchiolysis: correction of the undescended testicle without fixation.


Guanyl cyclase in rat brain subcellular fractions.


Rapid death in childhood.

Rapid death in childhood.


Bacterial variants in central nervous system infections in infants and children.


Introduction of new therapeutic drugs in the United States and Great Britain: an international comparison.


Rural Physicians Associate Program 1971-1972.


Pre-morbid adjustments, schizoid personality and onset of illness as predictors of post-hospitalization functioning.


Fracture conference. Puncture wounds of the foot.


Organization of the outer synaptic layer in the retina of the larval tiger salamander.


Radioimmunoassay for the cyclic nucleotides.


Metabolism of salicylazosulfapyridine in healthy subjects and in patients with ulcerative colitis. Effects of colectomy and of phenobarbital.


Human histocompatibility antigens and susceptibility to disease.


American Association of Medical Assistants.


Comparison of activities of drug-metabolizing enzymes in human fetal and adult livers.


The kinetics of formation and sensitivity to interferon of viral intermediates appearing in chick cells infected with Semliki Forest virus.


Formation of a 16,17-trans-glycolic metabolite from a 16-dehydro-androgen in human fetal liver microsomes.


The effect of cytosine-arabinoside on the multiplication of cytomegalovirus and on the formation of virus-induced intracellular antigens.


Effect of trimepranol, a beta blocker, on plasma levels of growth hormone, insulin, glucose, and free fatty acids.


Dependence of antiviral activity on molecular weight in an interferon stimulator of the natural double-stranded RNA type.


Interference between A2 and B influenza viruses and adenovirus in cell culture.


In vivo studies of infectious influenza virus-antibody complex.


Interferon tolerance and antiviral protection in mice given single or multiple injections of endotoxin or poly I : C.


Viscerotropism of rabies-like strains isolated from murine rodents.


Pathogenicity of laboratory-maintained and low-passaged strains of Herpesvirus hominis in suckling mice. A comparative fluorescent antibody study.


Some properties of maize rough dwarf virus subviral particles.


Susceptibility of Aedes albopictus mosquito cell line to some arboviruses.


Use of the sodium deoxycholate sensitivity test in cell cultures.


Sedimentation and buoyant density characteristics of influenza virus ribonucleoprotein.


Growth of California group viruses in tissue fragments.


The highly attenuated E5"14" plaque-cloned derivative from the Langat TP21 E5 strain. Isolation and properties.


Competative inhibition of haemagglutination of tick-borne encephalitis virus by receptor-analogue substances.


Response of brain amino acids to drugs and environmental conditions.


The primary processes of photosynthesis.


Studies of anaesthesia in relation to hypertension. V. Adrenergic beta-receptor blockade.


Oral atropine and practolol premedication in dental anaesthesia.


Pneumococci with increased resistance to penicillin.


Transmitters and reticulospinal neurons.


Influences of phenylephrine and orciprenaline on the release of noradrenaline.


Photoinactivation of porcine D-amino acid oxidase with flavin adenine dinucleotide.


Methotrexate binding to dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.


Evidence for two reduced triphosphopyridine nucleotide binding sites on dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.


Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid.


Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii.


The physician assistant in anesthesiology?


Effects of neutral aminoacids injected into cerebrospinal fluid space on glucose metabolism in the rat brain.


The role of biogenic amines in the reserpine-induced alteration of minimal electroshock seizure thresholds in the mouse.


Anticholinergic poisoning: treatment with physostigmine.


Cancer in the new-born.

Cancer in the new-born.


Chemotherapy of solid tumors.

Chemotherapy of solid tumors.


L-tryptophan inhibition of tyrosine aminotransferase degradation in rat liver in vivo.


Stearyl-CoA desaturase of bovine mammary microsomes.


Plasma levels of anticonvulsants.

Plasma levels of anticonvulsants.


Workshop on paediatric education. XII. International Congress of Pediatrics, Mexico City, November 30, 1968: working document.


Reduced pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes.


Nicotinamide adenine dinucleotide as substrate of the nucleotide phosphotransferase from Escherichia coli.


The graft-versus-host reaction to minor alloantigens.


Aromatic amino acid metabolism in brindled (Mobr) and viable-brindled (Movbr), two alleles at the mottled locus in the mouse.


A theoretical note on personality characteristics of heroin addicts.


MMPI characteristics of college freshman males who later became alcoholics.


Automated fluorometric analysis of reserpine and syrosingopine tablets, using a vanadium pentoxide reagent.


The pharmacotherapy of Parkinsonism.

The pharmacotherapy of Parkinsonism.


Saturated fatty acid biosynthesis and its regulation.


Comparative biochemistry of nitrogen fixation.


Insecticide biochemistry.

Insecticide biochemistry.


Bacterial cell surface polysaccharides.

Bacterial cell surface polysaccharides.


Hereditary influence on the normal personality using the MMPI. I. Age-corrected offspring resemblances..


Immunochemical evidence for the participation of cytochrome b5 in microsomal stearyl-CoA desaturation reaction.


On the mechanism of L-dopa-induced postural hypotension in the cat. 1. The effects of L-DOPA on postural hypotension and carotid occlusion pressor effect were studied, mainly in cats; the recovery of the blood pressure upon tilting was used as a measure of postural hypotension.2. L-DOPA (30 mg/kg) partially depressed the carotid occlusion pressor effect and caused some degree of postural hypotension, L-DOPA (100 mg/kg) had more marked effects; the responses returned to control after 90 to 150 minutes. L-DOPA itself caused a pressor response in all cats.3. The dopa decarboxylase inhibitor N(1)-(DL-seryl)-N(2)-(2,3,4-trihydroxybenzyl) hydrazine (RO4-4602, 50 and 10 mg/kg) had no effect itself on the tilt response but completely prevented the effects of L-DOPA on the carotid occlusion pressor effect and postural hypotension.4. After RO4-4602 (3 and 1 mg/kg), L-DOPA (100 mg/kg) caused a brief rise of blood pressure followed by a longer lasting fall in horizontally-orientated cats (i.e. ;supine' hypotension). No postural hypotension was observed after L-DOPA under these conditions.5. Noradrenaline elicited only small and transient effects on postural hypotension, but dopamine's effects were more marked and longer lasting. Pressor dose-response relationships for noradrenaline were the same before and after L-DOPA, as well as in cats pretreated with L-DOPA for 4 days.6. In cats with kidneys and intestines removed, the tilt reflex was still present. Dose-response curves to L-DOPA were the same as in normal animals. RO4-4602 (3 mg/kg) prevented postural hypotension and block of the carotid occlusion pressor effect; supine hypotension was also observed after L-DOPA.7. The recovery response to tilting in spinal cats was markedly depressed or absent unless the blood pressure was elevated by angiotensin, in which experiments L-DOPA depressed the recovery upon tilting (i.e. induced postural hypotension).8. Blood pressure responses to tyramine were increased after 10 mg/kg of L-DOPA, but depressed after 100 mg/kg. The response to tyramine was not depressed, however, when RO4-4602 was given to block the dopa-dopamine conversion.9. The response to sympathetic stimulation in pithed rats was depressed after L-DOPA and dopamine, but not after alpha-methyldopa.10. alpha-Methyldopa (300 mg/kg) given acutely caused a moderate degree of postural hypotension and a more marked postural hypotension if given for two days.11. It is concluded that it is possible to differentiate between the supine and postural hypotension caused by L-DOPA and that supine hypotension is due to a central effect and postural hypotension to an extracerebral effect. Postural hypotension is discussed in relation to six hypotheses presented to explain its effect. Postural hypotension after L-DOPA is probably not due to a-adrenoceptor blockade, a central effect or any effect on the kidney. The most likely hypothesis is that L-DOPA forms dopamine which acts as a false transmitter in the peripheral sympathetic nervous system.


The effect of  -adrenoceptor blockade on human sweating. 1. Changes in cutaneous water loss were followed by continuously monitoring total body weight loss.2. Sweating was induced in normal subjects by raising the environmental temperature or by subjecting them to the emotional stress of mental arithmetic.3. Propranolol in a dosage of 0.15 mg/kg body weight intravenously had no significant effect on either thermal or emotional sweating, whereas thermal sweating was completely blocked temporarily by administration of atropine 2.4 mg intravenously.4. It is concluded that beta-adrenoceptor blockade has no effect on physiological sweating in normal people.


Pharmacokinetics of M&B 17,803A in animals and man.


Acute systemic anaphylaxis in the calf.

Acute systemic anaphylaxis in the calf. 1. Acute systemic anaphylaxis in calves was characterized by marked systemic hypotension; hypertension in the pulmonary arteries and abdominal vena cava, and transient apnoea. Calves responded with a second reaction to antigen, but a third anaphylactic response could not be evoked.2. Suppression of systemic anaphylaxis could not be effected with mepyramine, whereas methysergide or diethylcarbamazine each suppressed anaphylaxis by 50%. Disodium cromoglycate alone did not inhibit anaphylaxis: however, when disodium cromoglycate was combined with diethylcarbamazine almost total suppression (85%) was achieved. Sodium meclofenamate also was a powerful inhibitor of anaphylaxis (80%). It is tentatively suggested that slow reacting substance (SRS-A) may be an important mediator of bovine anaphylaxis.3. Bilateral vagotomy did not modify the circulatory responses to injected histamine, 5-hydroxytryptamine (5-HT) or antigen, whereas the effects of these agents on ventilation (apnoea) were abolished by vagotomy.4. Plasma histamine concentration was increased during anaphylaxis, whereas plasma 5-HT was not. Whole blood histamine concentration fell sharply and remained depressed during 20 min of anaphylactic shock. Reduced whole blood histamine levels probably reflect the severe leucopoenia in the calves.5. Histamine concentrations in six tissues taken from calves subjected to anaphylaxis were not different from those in control calves; mast cells were of similar numbers to controls, but showed some swelling, granular spilling and metachromasia.6. Histamine, 5-HT, bradykinin and antigen caused increased pulmonary artery perfusion pressure and ventilation resistance in isolated lungs from sensitized calves. However, there was no difference in histamine and 5-HT concentration in perfusates obtained during antigen infusion of sensitized and control lungs.7. Systemic anaphylaxis of calves may result from the interaction of histamine, 5-HT and SRS-A. The present data implicate (by indirect measurement) SRS-A as an important mediator of anaphylaxis in this species.


Isoprenaline antagonism and duration of action in exercise induced tachycardia of three  -adrenoceptor blocking drugs: pindolol, LF 17-895 and propranolol.


The occurrence of tryptamine in rat brain and its pharmacological manipulation.


Cardiovascular and respiratory effects of cannabis extracts and  1-tetra-hydrocannabinol ( 1-THC).


Induction of liver microsomal drug metabolism in newly-hatched chicks.


The effect of AH 5158, pindolol, propranolol, D-propranolol on acute exercise tolerance in angina pectoris.


The  -adrenoceptor blocking activity of desacetylthymoxamine on human isolated smooth muscle.


The buccal absorption of some  -adrenoceptor blocking drugs.


Studies of glutamate dehydrogenase. The influence of ADP, GTP, and L-glutamate on the binding of the reduced coenzyme to beef-liver glutamate dehydrogenase.


A comparative study of pig and sheep-brain glutamine synthetases: tryptic peptides and thiol groups.


Properties of a yeast cytochrome P-450-containing enzyme system which catalyzes the hydroxylation of fatty acids, alkanes, and drugs.


An outbreak of dengue-type fever among royal marines in Sabah--1964.


Evidence for participation of a catecholaminergic mechanism in the post-castration rise in plasma gonadotropins.


Systemic corticosteroid therapy in rheumatic diseases.


Isolation of St. Louis encephalitis and Cache Valley viruses from Saskatchewan mosquitoes.


Angina pectoris.

Angina pectoris.


Clinical assessment of bronchodilator drugs delivered by aerosol.


Stereochemistry of reduction of D-glyceraldehyde catalyzed by a nicotinamide adenine dinucleotide phosphate dependent dehydrogenase from skeletal muscle.


Interactions of reduced and oxidized triphosphopyridine nucleotides with the electron-transport system of bovine heart mitochondria.


Regional distribution of some enzymes involved with putative neurotransmitters in the human visual system.


Time and level of increased plasma corticosterone necessary for induction of liver tyrosine aminotransferase in rats subjected to trauma.


Drugs in cardiogenic shock.

Drugs in cardiogenic shock.


Assay of ipecac and its preparations. II. Collaborative study.


Identification of phenothiazine derivatives and analogs by x-ray diffraction. I. Examination of pure compounds.


Assay of ipecac and its preparations. I. Development of the method.


Identification of phenothiazine derivatives and analogs by x-ray diffraction. II. Active substances in pharmaceutical formulations.


Non-otogenic cerebral abscess.

Non-otogenic cerebral abscess. Non-otogenic cerebral abscess is becoming relatively more frequent compared with otogenic. It arises in a setting of sepsis, trauma, or congenital heart disease. The onset presents a meningo-encephalitic picture, often with two stages, followed by epilepsy and/or a hemiparesis. The best investigations are an EEG and, probably, an isotope scan. The angiogram may be misleading as 40% may not have a midline shift. 'Acute localized non-suppurative encephalitis' seems to be more frequent than in the past. Antibiotics and aspiration appear to be the best treatment.


Oxidation of NADH in a coupled oxidase-peroxidase reaction and its significance for the fermentation in rumen protozoa of the genus Isotricha.


Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae. I. Enzyme levels in ade3-41 and ADE15, a dominant adenine auxotroph.


Mutations affecting levels of tetrahydrofolate interconversion enzymes in Saccharomyces cerevisiae. II. Map positions on chromosome VII of ade3-41 and ADE15.


Implanted-pacemaker-induced dysrhythmia and its management.


Comparison of propranolol and Ro 3-3528 in hyperthyroid tachycardia and dysrhythmias.


Effect of monolayer fractionation of lymphocytes on graft-versus-host reactivity.


The effect of antihistamines on the suppression of skin tests.


Surgery and anticoagulation therapy.

Surgery and anticoagulation therapy.


Continuing medical education and professional growth--"the physician's protection".


Case report: celiac artery aneurysm.

Case report: celiac artery aneurysm.


Illinois Emergency Medical Service System. Status report II (July, 1973).


Febrile reaction of Gaucher's disease.

Febrile reaction of Gaucher's disease.


Gunshot wound of the back.

Gunshot wound of the back.


Selecting medical students.

Selecting medical students.


Herman von Helmholtz, 1821-1894 physician, musician and versatile scientist.


The viewbox: gallstone obstruction of the colon.


EKG of the month: Myocardial infarct and arrhythmia.


Beta blockade.

Beta blockade.


The pharmacological characterization of beta-sympathicolytic substances.


On the importance of a central beta-adrenoceptor site in the antiarrhythmic activity of beta-blockers.


LB-46 in angina pectoris. A critique of anti-anginal drug assessment.


A preliminary report on the duration of beta-blockade after oral intake of L-B46.


Side-effects of beta-adrenergic blocking drugs in asthmatics.


Anti-arrhythmic effects of LB-46 on experimentally produced digitoxic arrhythmias.


The hypotensive action of LB 46.

The hypotensive action of LB 46.


The effect of LB 46 on the blood pressure in essential hypertension.


Treatment of psycho-neurotic conversion reactions with pindolol. (Effect on cardio-vascular response to exercise).


Dechlorination of chloroethane with a reconstituted liver microsomal system.


Calf thymus GMP reductase: control by XMP.


The second messenger system of mouse epidermis. 3. Guanyl cyclase.


Determination of gamma glutamyl transpeptidase activity in human serum. Its use in oncology.


Heme-modification studies of myoglobin. II. Ligand binding characteristics of ferric and ferrous myoglobins containing unnatural hemes.


Antinuclear antibodies in hybrid mice inoculated with parental spleen cells.


In vitro and in vivo metabolism of 3-trifluoromethyl-4-nitrophenol (TFM) in rainbow trout.


Vaccination against schistosomes? Report of an expert conference sponsored by the Rockefeller Foundation.


The level of questions posed by nursing educators.


Utilizing questioning strategies in nursing education.


The nursing student: social background, attitudes, and expressed willingness to work in poverty programs.


Criteria for choosing textbooks for the nontraditional professional nursing curriculum.


Hyperpyrexia from drug combinations.

Hyperpyrexia from drug combinations.


Attitudes of cynicism and humanitarianism in nursing students and staff nurses.


Isozymic heterogeneity in Tetrahymena strains. Examination of electrophoretic mobility patterns indicates that the strain designations of 44 classical strains of Tetrahymena are confused. It is suggested that new designations be made on the basis of phenotypic similarity.


Current therapy of shock.

Current therapy of shock.


Cell-mediated immunity.

Cell-mediated immunity.


Drug treatment of hyperactivity in children.


Confusing urinary bladder defects and configurations.


"The way to a man's heart attack".

"The way to a man's heart attack".


Multiloculated cystadenoma of the liver.


Gas infection of thigh.

Gas infection of thigh.


Repeated bouts of pneumonitis cough with feedings and abdominal distention.


A statewide system for post-traumatic renal failure.


A heroin addiction scale revisited.

A heroin addiction scale revisited.


The past four decades of progress in the knowledge of gout, with an assessment of the present status.


Malignant lymphoma and amyloidosis following graft-versus-host reaction.


Studies on inflammation in the sheep, using turpentine-induced pleurisy as a test system. 2. Suppression of the increased vascular permeability by specific antagonists of chemical mediators, anti-inflammatory agents and other substances.


Membrane effects of beta-adrenergic blocking agents: investigations with the fluorescence probe 1-anilino-8-naphthalene sulfonate (ANS) and antihemolytic activities.


Effect of excess and deficient copper intake on rat liver microsomal enzyme activity.


Effect of olivomycin on the induced synthesis of tyrosine aminotransferase and tryptophan oxygenase in rat liver.


Effect of chronic feeding on the activities and submicrosomal distribution of reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase and the demethylases for aminopyrine and ethylmorphine.


Prostaglandin-versus alpha-adrenoceptor-mediated control of sympathetic neurotransmitter secretion in guinea-pig isolated vas deferens.


The model of functional interaction. I. Development and first check of a new model of functional synergism and antagonism.


The model of functional interaction. II. Experimental verification of a new model: the antagonism of beta-adrenoceptor stimulants and other agonists.


Modulating effect of central adrenergic neurones on a vagally mediated cardioinhibitory reflex.


A further attempt to characterize sedative receptors activated by clonidine in chickens and mice.


Thymic involution and ageing.

Thymic involution and ageing.


Rabies prophylaxis--a primer.

Rabies prophylaxis--a primer.


Studies of histoplasmosis in two Illinois communities.


Accidental ingestion.

Accidental ingestion.


Nonketotic hyperglycemic coma in infancy.


Ulcer recurrence after vagotomy and pyloroplasty.


Delayed ovulation.

Delayed ovulation.


The use and abuse of antibiotic and chemotherapeutic remedies.


Traumatic rupture of thoracic aorta.

Traumatic rupture of thoracic aorta.


The story of rheumatology in Chicago.

The story of rheumatology in Chicago.


Disability insurance under social security.


The aminoterminal sequence of antibody light chains: evidence for possible inheritance of structural genes.


Vector control in Arkansas.

Vector control in Arkansas.


Insect developmental inhibitors. 2. Effects on target mosquito species.


Protective effect of cyproheptadine and BC 105 against the lethal effects of exudates from rat burnt skin.


Cardiology for the practitioner. II. The medical management of angina pectoris.


Treatment of hemorrhagic shock with a new vasodilator.


Neuroendocrine aspects of thermoregulation.


Leukocyte adenyl cyclase and ATPase in asthma: effect of corticosteroid therapy.


Rapidity of response to the treatment of enuresis.


The specificity of yeast fatty-acid synthetase with respect to the "priming" substrate. Decanoyl-coA and derivatives as "primers" of fatty-acid synthesis in vitro.


Omega-hydroxylation of steriod side-chain in biosynthesis of bile acids.


Reduction of C19-, C21-, C24-, and C27-3-oxosteroids by rat-liver microsomes.


A study of the dental caries status of the preschool children among the play centers of health district I and II, Manila Health Center.


Activation of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of clonidine.


Teething, diet and health. 6.

Teething, diet and health. 6.


Ethanol metabolism in the liver.

Ethanol metabolism in the liver.


Antifibrillatory effect of beta-adrenergic agonists.


Immunologic reconstitution.

Immunologic reconstitution.


Evaluation of clinical and antibacterial activity of pyrrolidinemethyltetracycline.


Stereoisomerism and drug action in the nervous system.


The treatment of atopic dermatitis.

The treatment of atopic dermatitis.


Resolution of optical isomers of 5-allyl-5-(beta-hydroxypropyl)-barbituric acid (Ipronal, Axeen) and their pharmacological activity.


Cocaine and catecholamine interaction. A review.


Undescended testicle.

Undescended testicle.


Metabolism of volatile anaesthetics.

Metabolism of volatile anaesthetics.


Antimetabolites of coenzyme Q. 14. Quinolinequinone analogs which inhibit mitochondrial DPNH-oxidase and succinoxidase.


Derivatives of 3,4-dihydro-1(2H)-naphthalenone as beta-adrenergic blocking agents. 2. Aromatic-substituted analogs of bunolol.


Electron impact fragmentation studies of beta-blocking drugs and their metabolites by GC-mass spectroscopy.


Conformation effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic beta-receptor blocking activity of 2-(p-nitrophenyl)-4-isopropylmorpholine.


Immunosuppression and neoplasia. I. A critical review of experimental carcinogenesis and the immunesurveillance theory.


A rapid embedding technique for electron microscopic study of a bovine herpesvirus.


The relationship between antagonistic properties and serologic type in staphylococci of bacteriophage group II.


Treatment of the cardiomyopathies.

Treatment of the cardiomyopathies.


Islet cell tumors: current concepts and management.


The sick sinus syndrome.

The sick sinus syndrome.


The purification of nicotinamide nucleotide-dependent dehydrogenases on immobilized cofactors. 1. The general applicability of affinity chromatography to the purification of nicotinamide nucleotide-dependent dehydrogenases on immobilized cofactors is illustrated with several examples taken from crude systems. 2. Methods for overcoming the inevitable loss of selectivity experienced with these polymers are suggested. Effective use of the appropriate nucleotide, the second substrate and other interacting ligands can be made to selectively alter the chromatographic behaviour of the desired enzyme.


Duration of action of beta-blocking drugs.


Studies on the interaction between catecholamines and tyrosine aminotransferase in brain.


CCl4-induced damage to endoplasmatic reticulum membranes.


On the convulsive action of castrix.

On the convulsive action of castrix.


Decarboxylase inhibition and structure-activity relationship studies with some newly synthetized benzyloxyamine and pyridylmethoxyamine derivatives.


The NAD-linked isocitrate dehydrogenase activity in rat-liver mitochondria.


On the oxidation of reduced nicotinamide dinucleotide phosphate by submitochondrial particles from beef heart.


Marijuana smoking: effects on blood and urine in man.


The effects on cardiac muscle and nerve of a fluorinated decahydroquinoline derivative, L7810, rapidly absorbed after oral administration. 1. L7810 (4-carbamoyloxy-1-(4-(4-fluorophenyl)-4-oxobutyl) decahydroquinoline, has a local anaesthetic action on frog nerve 1.75 times that of procaine.2. L7810 protected anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation and increased the lethal dose of ouabain.3. L7810 reduced the rate of rise of intracellularly recorded action potentials in rabbit isolated atria; the resting potential was not affected, but the duration of the action potential was prolonged.4. Unlike most drugs with local anaesthetic properties L7810 did not depress contractions in isolated atria but increased them.5. L7810 reduced the spontaneous frequency, maximum follow frequency and conduction velocity of rabbit isolated atria.6. L7810 had no blocking action on the chronotropic or positive inotropic actions of isoprenaline on isolated atrial muscle.7. In anaesthetized dogs L7810 caused a small dose-related bradycardia, and a large dose-related decrease in peripheral vascular resistance. There was no blockade of the effects of isoprenaline on heart rate or peripheral blood flow.


Beta-adrenoceptor blocking properties and cardioselectivity of M & B 17,803A. 1. The beta-adrenoceptor blocking properties of (+/-)-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M&B 17,803A) have been compared with those of practolol and propranolol in the guinea-pig, cat and dog.2. Following either intravenous or oral administration in the cat or dog, M&B 17,803A and practolol had similar potency in antagonizing isoprenaline-induced tachycardia and both showed cardioselectivity, but both were less potent than propranolol.3. M&B 17,803A and practolol had approximately one hundredth the intravenous potency of propranolol in increasing the severity of anaphylactic bronchospasm in the conscious sensitized guinea-pig.4. M&B 17,803A possessed less marked intrinsic sympathomimetic activity than practolol but, like propranolol, it had significant local anaesthetic properties and increased the refractory period of rabbit isolated atria.


A new type of cardioselective adrenoceptive blocking drug.


The action of ICI-66082 on the heart.

The action of ICI-66082 on the heart.


The blocking effects of propranolol, practolol and ICI-66082 on the peripheral vascular responses to isoprenaline.


Effect of intraperitoneal administration of (+)-INPEA on oxytocin and prostaglandin evoked responses of the isolated rat uterus.


Evidence of a role for brain monoamines in ethanol dependence.


Electrically induced contractions of guinea-pig isolated ileum resistant to tetrodotoxin.


Application of the dansyl technique to an investigation into the identity of the primary sensory transmitter in the spinal cord.


Antagonism by burimamide of inhibitions induced by histamine in plexus-containing longitudinal muscle preparations from guinea-pig ileum.


Evidence for a non-adrenergic inhibitory nervous pathway in guinea-pig trachea.


A study of the role of catecholamines in the response to various central stimulants.


Actions of beta-blocking agents on membrane excitability of the lobster giant axon.


Continued pharmacologic analysis of consummatory behavior in the albino rat.


Further studies on the site of action of nicotinic blocking drugs.


Ammonium repression in a mutant of Saccharomyces carlsbergensis lacking NADP dependent glutamate dehydrogenase activity.


Electrochemical redox pattern for nicotinamide species in nonaqueous media.


Carbon-13 magnetic resonance spectroscopy and the biosynthesis of streptovaricin.


Evaluation of liquid-liquid systems for the chromatographic separation of the psychotropic thioridazine and it's metabolites.


Enzyme assay in microsomes below zero degrees. Reactions of a membrane-bound multienzyme complex (electron-transport chain of rat-liver microsomes) suspended in aqueous-organic solvent used as antifreeze at temperatures below 0 degrees were studied. In the presence of a relatively high concentration of ethylene glycol, electron transfer can still be observed and some individual and sequential enzyme assays can be performed over a wide range of temperatures below 0 degrees .


Changing concepts of hepatitis B infection.


The reduction of certain C-nitroso compounds by rat liver cytosol.


Oxidation of reduced nicotinamide hypoxanthine dinucleotide phosphate by intact rat liver mitochondria.


NADH(NADPH): (acceptor) oxidoreductase activities of the bovine adrenal chromaffin granules.


The function and localization of ubiquinone in the NADH and succinate oxidase systems of Rhodopseudomonas palustris.


Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia.


Fractionation by sucrose density gradient centrifugation of membrane fragments derived by sonic disruption of beef heart mitochondria.


The responsiveness of tolerant lymphocyte populations after transfer to normal recipients.


Graft-vs-host reaction with an H-2 mutant.


Cross-reactions of additional extracellular polysaccharides of Klebsiella.


Xenogeneic reactivity of human fetal lymphocytes.


Histochemical studies on the Leydig-cell-leucine aminopeptidase activity in the guinea-pig testis.


Neurological complications of the rheumatic diseases.


Accumulation of 125I-labelled albumin as a measure of the inflammatory response in experimental arthritis.


Studies on new sympathomimetic beta-receptor stimulating drugs in asthmatic patients. I. The bronchodilator and circulatory effects of subcutaneous terbutaline.


An anatomy of schizophrenia?

An anatomy of schizophrenia?


Acyl coenzyme A inhibition of Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase: a comparison of the TPN and DPN linked reactions.


NADPH-D-glyceraldehyde 3-phosphate oxidoreductase activity in muscle and other tissues of the rat.


Similarities in the bioluminescence from the Pennatulacea.


Cross-reactions of polysaccharides of Lipomyces in antipneumoccal and other antisera.


Action of prostaglandin E-1 (PGE-1) on human pregnant (at the time of labor) and non-pregnant uterus in vivo and modification of this action by adrenergic receptor blocking agents.


Studies on the function of cell membrane. l. Leakage of NADH-cytochrome c reductase into plasma from liver cells in CC4-poisoned rats.


Patterns of cytochrome oxidase inhibition by polycations.


Involvement of adrenergic mechanism in the diuretic action of o-chlorobenzyl methyl sulfoxide (DS-30) in the rat.


Antisympathomimetic effects of Kö 1313 and Kö 1366 in guinea-pig atria.


Bacterial attack on phenolic ethers. Dealkylation of higher ethers and further observations on O-demethylases.


Irreversible protein binding of metabolites of ethynylestradiol in vivo and in vitro.


Steroid metabolism by mouse submaxillary glands. I. In vitro metabolism of testosterone and 4-androstene-3,17-dione.


Experimental allergic sialoadenitis. VI. Prevention by antihistamine and induction by intraductal instillation of performed immune complexes.


Acetyl-CoA and propionyl-CoA carboxylation by Mycobacterium phlei. Partial purification and some properties of the enzyme.


Tetracycline-resistant pneumococci: increasing incidence and cross resistance to newer tetracyclines.


The stimulatory effect of tumor bearing upon the T- and B-cell subpopulations of the mouse spleen.


Tritiated leucine incorporation by Sertoli cells in scrotal and cryptorchid rat testes.


Adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices: effects of alpha- and beta-adrenergic agents, histamine, serotonin and adenosine.


The effect of the convulsant 3-mercaptopropionic acid on enzymes of the gamma-aminobutyrate system in the rat cerebral cortex.


An assay procedure for tryptamine in brain and spinal cord using its (3H)dansyl derivative.


Activities of tyrosine aminotransferase in various human tissues.


Effect of age, cryptorchidism and hypophysectomy on cyclic AMP concentration in rat testis.


Cerebral arteritis: classification.

Cerebral arteritis: classification.


Adrenergic control mechanism for ACTH secretion in man.


Studies on the mechanism of iodination supported by thyroidal NADPH-cytochrome c reductase.


Pilot trials with long-acting pipotiazine injections.


A controlled one-year study of pipotiazine palmitate and fluphenazine decanoate in chronic schizophrenic syndromes. Evaluation of results at 6 and 12 months' trial.


Clinical evaluation of a new depot neuroleptic. A pilot study with pipotiazine undecylenate (19.551 R.P.).


Clinical experience with pipotiazine palmitate (19.552 R.P.) in Nordic countries. Report of a multicentre investigation.


General evaluation of pipotiazine palmitate in hospitalized and open ward patients with functional psychosis.


Genetic and epidemiologic studies of oral characteristics in Hawaii's schoolchildren: dietary patterns and caries prevalence.


Caries prevalence in children from the United States.


General evaluation of pipotiazine palmitate (19.552 R.P.) in hospitalized schizophrenic patients.


Clinical evaluation of pipotiazine palmitate (19.552 R.P.) used on patients in an acute reception ward.


Pipotiazine palmitate (19.552 R.P.) in the long-term treatment of chronic psychoses. A controlled trial on in-patients.


Controlled clinical evaluation of depot neuroleptics. A double-blind trial with pipotiazine undecylenate and fluphenazine enanthate.


An obstetric and gynecologic associate program.


Editorial: Bone-marrow transplants for immunodeficiency syndromes.


Pharmacological study of pipotiazine (19.366 R.P.) and its undecylenic (19.551 R.P.) and palmitic (19.552 R.P.) esters.


Metabolism of cholesteryl palmitate by rat brain in vitro; formation of cholesterol epoxides and cholestane-3beta,5alpha,6beta-triol. Incubation of [4-(14)C]cholesteryl palmitate with the 12,000 g supernatant fraction of adult rat brain fortified with an NADPH-generating system and beta-mercaptoethylamine resulted in formation (2-5%) of more polar metabolites characterized as a mixture of cholesterol-5,6-epoxides. Under extended incubation conditions, cholestane-3beta-5alpha-6beta-triol was isolated as the major end product of the incubations. Free [4-(14)C]cholesterol incubated under similar conditions was not oxidized, whereas oxidation of [4-(14)C]cholesteryl palmitate appeared to be dependent upon hydrolysis of the ester by the rat brain microsomal subcellular fraction. Elimination of the NADPH-generating system or the addition of EDTA to the incubation mixture inhibited epoxide formation, suggesting that the products are derived from an NADPH-dependent enzymatic lipoperoxidation mechanism. The in vitro conversion of [4-(14)C]cholesterol-5alpha,6alpha-epoxide to cholestane-3beta,5alpha,6beta-triol was also demonstrated in rat brain subcellular fractions in the absence of added cofactors.


Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. A new assay for 3-hydroxy-3-methylglutaryl CoA reductase (mevalonate:NADP oxidoreductase [acylating CoA], EC 1.1.1.34) is based upon the measurement of released coenzyme A (SH) during the reduction of 3-hydroxy-3-methylglutaryl CoA to mevalonate. Coenzyme A was measured in the presence of dithiothreitol, required for activity, by reaction with 5,5'-dithiobis(2-nitrobenzoic acid). Sodium arsenite forms a complex with the dithiol, but not with monothiols. Thus, reduced coenzyme A reacts instantaneously with the reagent and dithiothreitol reacts slowly. The absorbance due to the coenzyme A-5,5'-dithiobis(2-nitrobenzoic acid) reaction is determined by extrapolating the linear (dithiol) absorbance-time curve to the time of addition of the reagent. After subtraction of control absorbance (deletion of NADPH), the concentration of CoA-SH is calculated from epsilon(max) = 1.36 x 10(4) at 412 nm. The method of protein removal and reduction of sulfhydryl groups on the enzyme are critical. This method provides an immediate assay. Recovery of reduced coenzyme A was 98.7%. The assay is applicable for microsomes or purified enzyme and has an effective range of 0.5-50 nmoles of coenzyme A. It was applied to kinetic measurement of the pigeon liver microsomal enzyme reaction. The apparent K(m) value for 3-hydroxy-3-methylglutaryl CoA was 1.75 x 10(-5) M, and for NADPH the value was 6.81 x 10(-4) M. This method was compared with the dual-label method at high and low levels of activity. The data were not statistically different.


Liver dehydrogenase levels in rainbow trout, Salmo gairdneri, fed cyclopropenoid fatty acids and aflatoxin B1. Cyclopropenoid fatty acids in the diet of rainbow trout caused significant reductions in liver protein and activity of glucose-6-phosphate dehydrogenase, NADP-linked isocitrate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase. Changes in total activity were usually accompanied by similar changes in specific activity. The activity of glucose-6-phosphate dehydrogenase appeared to be more sensitive to the ingestion of cyclopropenoid fatty acids than the other dehydrogenases studied. Feeding 20 ppb aflatoxin B(1) to rainbow trout did not significantly change the activity of the dehydrogenases except for a small increase in the activity of glucose-6-phosphate dehydrogenase after 21 days of feeding. Relationships of these changes to the cocarcinogenicity of cyclopropenoid fatty acids and the carcinogenicity of aflatoxin are discussed.


The prune belly syndrome. Report of 20 cases and description of a lethal variant.


Beta-adrenergic blockade in arrhythmias of acute myocardial infarction.


Respiratory stimulants: review of the literature and assessment of current status.


Histaminergic vasodilatation in the hindlimb of the dog.


Periodicity of susceptibility to pneumococcal infection: influence of light and adrenocortical secretions. Circadian periodicity of susceptibility to pneumococcal infection was altered but not abolished in blind or adrenalectomized mice. Serum corticosterone concentrations 24 hours after pneumococcal challenge were greatest in animals challenged at 0400 hours, a time when circulatory corticosterone is lowest; the smallest absolute increase in serum corticosterone followed challenge at 1600 hours.


Fear, reinforcing activities and degree of alcoholism. A correlational analysis.


Functions of baseplate components in bacteriophage T4 infection. I. Dihydrofolate reductase and dihydropteroylhexaglutamate.


Analysis of pineal and brain indole alkylamines by gas chromatography-mass spectrometry.


Use of mass fragmentography to detect subcellular localization of drug metabolites acting as false transmitters.


Effect of adrenergic receptor blockade on the response to prostaglandin E1 in canine ileum.


Immunosuppression by the bisdioxopiperazines ICRF 154 and 159.


Properties of purifed quinonoid dihydropterin reductase.


Phospholipid and protein metabolism in mouse liver mitochondria during riboflavin deficiency and recovery.


Some properties of a DNA-dependent RNA polymerase from Halobacterium cutirubrum.


Loss of graft-versus-host reactivity of mouse lymphocytes during serial passage through irradiated allogeneic hosts.


Program prototypes: programs in Philadelphia.


Bacterial meningitis complicating cranial-spinal trauma.


Studies on in vitro peroxidation of liver lipids in ethanol-treated rats.


Pneumococcal serotypes associated with acute pneumonia.


Impaired chronotropic response to beta-stimulation in chronic coronary artery disease.


Glucose-6-phosphate dehydrogenase Johannesburg: a new variant with reduced activity in a patient with congenital non-spherocytic haemolytic anaemia.


Interaction between catecholamines and vasopressin on renal medullary cyclic AMP of rat.


The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients. The metabolism of salicylazosulphapyridine was studied in 16 patients with ulcerative colitis admitted to hospital. The acetylator phenotype was determined on admission. The mean serum concentration (mug/ml) (at steady state eight +/- two days in patients responding to treatment) of SASP, total SP, and 5-ASA were 18.7 +/- 12.8; 53.7 +/- 23.1; and 1 +/- 0.9 for slow acetylators and 17.6 +/- 7.1; 31 +/- 9.0 and 1 +/- 0.9 for fast acetylators respectively. Twenty-four hour urinary excretion of SASP, total SP, and 5-ASA were 4.6% +/- 3.1; 52% +/- 9.6 and 22.3 +/- 6.7% of the administered dose respectively. Serum total SP concentration of 20 to 50 mug/ml appeared to coincide with clinical improvement in the absence of any side effects related to salicylazosulphapyridine. No such relationship could be shown with serum SASP, individual metabolites, or 5-aminosalicyclic acid.


Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate.


XXVII Wherry Memorial Lecture. Steroid therapy in otolaryngology.


Bacterial interference. II. Role of the normal throat flora in prevention of colonization by group A Streptococcus.


Lipophilic interactions of organic cations with mitochondrial inner membranes during respiratory control.


Isolation and properties of the envelope of spinach chloroplasts.


Enzyme activities in regenerating epithelium during wound healing. IV. Aminotransferases and NADP-dependent enzymes.


Rapid detection of gram-negative bacterial meningitis by the limulus lysate test.


Letter: Use of thymus in Millipore chambers for immunologic reconstitution.


Reduction in the concentration of nerve growth factor in mice after sialectomy and castration.


Effects of D- and DL-propranolol on myocardial adenyl cyclase activity.


Newly synthesized DNA and Bacillus subtilis DNA incorporated into transformable Diplococcus pneumoniae.


The effects of Chrysaora and Physalia venoms on mitochondrial structure and function.


Fluorescent spectra of lysergic acid diethylamide: observations on a gastric extract.


Purification and properties of isocitrate dehydrogenase (NADP) from Thermus aquaticus YT-1, Bacillus subtilis-168 and Chlamydomonas reinhardti-Y-2.


Specific changes in the activity of tyrosine aminotransferase isoenzymes in rat liver after cortisol treatment and partial hepatectomy.


Sulfinic and sulfonic analogs of gamma-aminobutyric acid and succinate semialdehyde, new substrates for the aminobutyrate aminotransferase and the succinate semialdehyde dehydrogenase of Pseudomonas fluorescens.


Tagetes minuta L., as a repellent and insecticide against adult mosquitoes.


Parkinson's disease. A genetic study.

Parkinson's disease. A genetic study.


Serologic evidence for antigens controlled by the Ir region in mice. Antibodies produced in B10.D2 mice against soluble lymphocyte membrane antigens of B10.A (H-2(a)) mice reacted only with lymphocytes of the strains carrying the Ir(k) region, i.e., B10.A(2R), B10.K, B10.BR, B10.HTT, AQR, A.TE, C3H, and CBA; they did not react with cells of strains carrying different Ir regions, i.e., B10.A(4R), B10, B10.M, A.SW, DBA/1. It is therefore concluded that the antigen detected with these antibodies is apparently controlled by the Ir region of the H-2 complex. The antigen is present on some T lymphocytes and absent on B lymphocytes. Its presence or absence seems to correlate with MLC and GVH reactivity.


Investigations on the catecholamine release in anaphylactic, anaphylatoxin, and histamine shock of quinea pigs.


Cefazolin in the treatment of bacterial pneumonia.


Evaluation of cefazolin in the treatment of bacterial endocarditis and bacteremia.


Induction of a primary antihapten response in vivo by a graft-vs.-host reaction. A primary anti-NIP PFC response can be elicited by a GVH reaction provided certain structural requirements of the NIP-carrier are met. NIP-coated F(1) erythrocytes and NIP-coated parental erythrocytes give rise to substantial anti-NIP PFC responses in F(1) mice after the injection of parental spleens. These conjugates do not of themselves give rise to an anti-NIP PFC response and, in fact, normally give rise to NIP-specific tolerance. In contrast the GVH reaction is not able to enhance the primary anti-NIP PFC response to immunogenic NIP-conjugates.


The meaning of statistics in dental literature.


Microbiologic studies on denture stomatitis.


Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver.


H2-receptor blockade and stimulation of histidine decarboxylase.


Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides.


A light and electron microscope study of the nervous system of Ceriantheopsis americanus (Cnidaria, Ceriantharia).


Release of DNA polymerase from rat liver chromatin on incubation with NAD.


International symposium on Hodgkin's disease. Conference held by the Stanford University School of Medicine, Stanford, California, March 20-24, 1972.


Acute infectious sinusitis in cyanotic congenital heart disease.


Mixed gonadal dysgenesis.

Mixed gonadal dysgenesis.


Some aspects of the physiology of the autonomic nervous system.


The major influence of a magnetic field on a nickel surface used for an immunoelectroadsorption assay.


Beta adrenergic blocking drugs. Present position and future development.


Immunochemical demonstration of increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine. Chronic administration of reserpine to rats increases, in sympathetic ganglia and adrenal medulla, the activity of tyrosine hydroxylase (EC 1.14.3.x), the enzyme catalyzing the rate-limiting step in the biosynthesis of catecholamines. Immunochemical titration of the enzyme in both adrenal gland and innervated superior cervical ganglia demonstrates that enhanced enzyme activity is entirely attributable to accumulation of more specific enzyme protein and not activation of preexistent enzyme molecules.


Cardioselective beta blockade in hypertrophic cardiomyopathy.


Effects of practolol administration on cardiac and renal function in patients with chronic atrial fibrillation.


One hundred fifty cases of cardiac arrhythmias treated with acta practolol (I.C.I. 50.172).


cardiac dysrhythmias during anaesthesia with special reference to practolol (Eraldine).


Adrenergic beta receptor inhibition and hyperthyroidism.


Production of superoxide ions in rat liver microsomes.


A "reagentless" fluorometric method for creatine kinase activity in serum.


On the fractionation of halophilic enzymes with ammonium sulphate.


European Organization for Caries Research. Abstracts of papers read. 20th Congress-Zurich, July 20 to 22, 1973.


Evaluation of enzyme histochemical observations for metabolic studies. A combined histochemical and biochemical investigation of experimentally induced skeletal muscle-changes. I. The histochemical investigation.


Tolerance to type 3 pneumococcal polysaccharide in monkeys.


Accelerated skin graft rejection following transfer of cells sensitized to a "weak" histocompatibility antigen(s).


Tissue typing: an experimental solution in the chicken.


Relationship between graft-vs-host reactivity and possession of the high leukemia genotype hr-hr.


Letter: The effects of cardioactive drugs on the performance of cultured foetal hearts.


Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituent.


Horizontal transmission of feline leukaemia virus.


Increase in histamine receptors on thymus-derived effector lymphocytes during the primary immune response to alloantigens.


Immunocompetent lymphocytes in human and primate marrow.


Depletion of complement during graft-versus-host reaction in a severe combined immunodeficiency patient after receiving a mismatched marrow transplant.


Dissociation of lymphocyte activation and graft-versus-host competence of blood cells after skin grafting in rats treated with antithymocyte and normal pig serum.


Quantitative determination of antihistamines in pharmaceutical preparations by ultra violet spectrophotometry.


Progress report on viral hepatitis.

Progress report on viral hepatitis.


The gastroionogram. A new approach in the performance of gastric analysis.


The physician manpower question revisited.


Two malic enzymes in Pseudomonas aeruginosa. Cell-free extract supernatant fluids of Pseudomonas aeruginosa were shown to lack malic dehydrogenase but possess a nicotinamide adenine dinucleotide (NAD)- or NAD phosphate (NADP)-dependent enzymatic activity, with properties suggesting a malic enzyme (malate + NAD (NADP) --> pyruvate + reduced NAD (NADH) (reduced NADP [NADPH] + CO(2)), in agreement with earlier findings. This was confirmed by determining the nature and stoichiometry of the reaction products. Differences in heat stability and partial purification of these activities demonstrated the existence of two malic enzymes, one specific for NAD and the other for NADP. Both enzymes require bivalent metal cations for activity, Mn(2+) being more effective than Mg(2+). The NADP-dependent enzyme is activated by K(+) and low concentrations of NH(4) (+). Both reactions are reversible, as shown by incubation with pyruvate, CO(2), NADH, or NADPH and Mn(2+). The molecular weights of the enzymes were estimated by gel filtration (270,000 for the NAD enzyme and 68,000 for the NADP enzyme) and by sucrose density gradient centrifugation (about 200,000 and 90,000, respectively).


Purification and characterization of ferredoxin-nicotinamide adenine dinucleotide phosphate reductase from a nitrogen-fixing bacterium. Evidence suggesting that Bacillus polymyxa has an active ferredoxin-NADP(+) reductase (EC 1.6.99.4) was obtained when NADPH was found to provide reducing power for the nitrogenase of this organism; direct evidence was provided when it was shown that B. polymyxa extracts could substitute for the native ferredoxin-NADP(+) reductase in the photochemical reduction of NADP(+) by blue-green algal particles. The ferredoxin-NADP(+) reductase was purified about 80-fold by a combination of high-speed centrifugation, ammonium sulfate fractionation, and chromatography on Sephadex G-100 and diethylaminoethyl-cellulose. The molecular weight was estimated by gel filtration to be 60,000. A small amount of the enzyme was further purified by polyacrylamide gel electrophoresis and shown to be a flavoprotein. The reductase was specific for NADPH in the ferredoxin-dependent reduction of cytochrome c and methyl viologen diaphorase reactions; furthermore, NADP(+) was the acceptor of preference when the electron donor was photoreduced ferredoxin. The reductase also has an irreversible NADPH-NAD(+) transhydrogenase (reduced-NADP:NAD oxidoreductase, EC 1.6.1.1) activity, the rate of which was proportional to the concentration of NAD (K(m) = 5.0 x 10(-3)M). The reductase catalyzed electron transfer from NADPH not only to B. polymyxa ferredoxin but also to the ferredoxins of Clostridium pasteurianum, Azotobacter vinelandii, and spinach chloroplasts, although less effectively. Rubredoxin from Clostridium acidi-urici and azotoflavin from A. vinelandii also accept electrons from the B. polymyxa reductase. The pH optima for the various reactions catalyzed by the B. polymyxa ferredoxin-NADP reductase are similar to those of the chloroplast reductase. NAD and acetyl-coenzyme A, which obligatorily activate NADPH- and NADH-ferredoxin reductases, respectively, in Clostridium kluyveri, have no effect on B. polymyxa reductase.


Reduced nicotinamide adenine dinucleotide oxidase activity and H2O2 formation of Mycoplasma pneumoniae. Cell-free extracts of Mycoplasma pneumoniae showed two distinct reduced nicotinamide adenine dinucleotide (NADH(2)) oxidase activities in the supernatant fraction. By ammonium sulfate fractionation and polyacrylamide gel electrophoresis, one activity not requiring flavine co-factors was precipitated by 50 to 70% ammonium sulfate concentration and identified with a slower-moving band on acrylamide gel electrophoresis; a second NADH(2) oxidase activity was flavine mononucleotide (FMN) dependent and associated with a more rapidly moving band; it could only be partially precipitated by ammonium sulfate concentrations ranging from 50 to 100%. Studies with alternate electron acceptors indicated the presence of a menadione, a 2,6-dichlorophenol indophenol and a very weak ferricyanide oxido-reductase activity, but no cytochrome c oxido-reductase, in the cell-free preparations. The NADH(2) oxidase activities of all fractions were relatively cyanide insensitive and were only minimally inhibited by flavoprotein and other respiratory chain inhibitors. H(2)O(2) formation was negligible unless FMN, but not flavine adenine dinucleotide (FAD), was added to the crude NADH(2) oxidase system; upon fractionation and electrophoresis, the H(2)O(2) formation was associated with the FMN-dependent, more rapidly moving NADH(2) oxidase band. This FMN-dependent NADH(2) oxidase-H(2)O(2) generating system may be a mechanism for the H(2)O(2) formation observed during glucose oxidation in the intact organism.


Regulation of the nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenases of Saccharomyces cerevisiae. Saccharomyces cerevisiae contains two distinct l-glutamate dehydrogenases. These enzymes are affected in a reciprocal fashion by growth on ammonia or dicarboxylic amino acids as the nitrogen source. The specific activity of the nicotinamide adenine dinucleotide phosphate (NADP) (anabolic) enzyme is highest in ammonia-grown cells and is reduced in cells grown on glutamate or aspartate. Conversely, the specific activity of the nicotinamide adenine dinucleotide (NAD) (catabolic) glutamate dehydrogenase is highest in cells grown on glutamate or aspartate and is much lower in cells grown on ammonia. The specific activity of both enzymes is very low in nitrogen-starved yeast. Addition of the ammonia analogue methylamine to the growth medium reduces the specific activity of the NAD-dependent enzyme and increases the specific activity of the NADP-dependent enzyme.


Localization of alkaline phosphatase in three gram-negative rumen bacteria. Of the three species (Bacteroides ruminicola, B. succinogenes, and Megasphaera elsdenii) of anaerobic gram-negative rumen bacteria studied, only B. ruminicola produced significant amounts of alkaline phosphatase. This enzyme, which is constitutive, showed a greater affinity for p-nitrophenylphosphate than for sodium-beta-glycerophosphate and was shown to be located exclusively in the periplasmic space of log-phase cells. Small amounts of this enzyme were released from these cells in stationary-phase cultures, but washing in 0.01 M MgCl(2) and the production of spheroplasts by using lysozyme in 0.01 M MgCl(2) did not release significant amounts of the enzyme. Exposure to 0.2 M MgCl(2) did not release significant amounts of the periplasmic alkaline phosphatase of the cell, and when these cells were spheroplasted with lysozyme in 0.2 M MgCl(2) only 25% of the enzyme was released. Spheroplasts were formed spontaneously in aging cultures of B. ruminicola, but even these cells retained most of their periplasmic alkaline phosphatase. It was concluded that the alkaline phosphatase of B. ruminicola is firmly bound to a structural component within the periplasmic area of the cell wall and that the enzyme is released in large amounts only when the cells break down. The behavior of alkaline phosphatase in this bacterium contrasts with that of conventional periplasmic enzymes of aerobic bacteria, which are released upon conversion into spheroplasts by lysozyme and ethylenediaminetetraacetic acid and by other types of cell wall damage. All three species of bacteria studied here, as well as bacteria found in mixed populations in the rumen, have thick, complex layers external to the double-track layer of their cell walls. In addition, B. ruminicola produces a loose extracellular material.


Formate dehydrogenase of Clostridium thermoaceticum: incorporation of selenium-75, and the effects of selenite, molybdate, and tungstate on the enzyme. The formation of the nicotinamide adenine dinucleotide phosphate-dependent formate dehydrogenase in Clostridium thermoaceticum is stimulated by the presence of molybdate and selenite in the growth medium. The highest formate dehydrogenase activity was obtained with 2.5 x 10(-4) M Na(2)MoO(4) and 5 x 10(-5) Na(2)SeO(3). Tungstate but not vanadate could replace molybdate and stimulate the formation of formate dehydrogenase. Tungstate stimulated activity more than molybdate, and in combination with molybdate the stimulation of formation of formate dehydrogenase was additive. Formate dehydrogenase was isolated from cells grown in the presence of Na(2) (75)SeO(2), and a correlation was observed between bound (75)Se and enzyme activity.


Inhibition of gamma-glutamylcysteine synthetase by L-methionine-S-sulfoximine.


Metabolic regulation by homoserine in Escherichia coli B-r. A mathematical analysis of branched pathway regulation has led to the prediction of a novel homoserine control in Escherichia coli B. Experimental support for such control is presented in this paper. Homoserine, the precursor of both threonine and methionine, inhibits nicotinamide adenine dinucleotide phosphate (NADP(+))-specific glutamate dehydrogenase (EC 1.4.1.4), the enzyme catalyzing the first reaction in ammonia assimilation. Physiological and biochemical evidence for this effect are offered. Homoserine depresses the growth rate of the organism, and glutamate, the product of the inhibited reaction, reverses this effect. The NADP(+)-specific glutamate dehydrogenase activity in cell-free extracts is inhibited by homoserine, and this inhibition parallels the restriction of growth rate. These effects are found in other enteric bacteria which share a similar overall pattern of control for the amino acids derived from aspartate. On the other hand, a sampling of more distantly related species which have different pathways and/or regulatory patterns provides no evidence for homoserine inhibition of the glutamate dehydrogenase reaction.


Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone.


Reductase, phosphatase, and kinase activities in the metabolism of alkyldihydroxyacetone phosphate and alkyldihydroxyacetone.


Beta-adrenergic blocking agents. 14. Microbiological reduction of isopropylaminomethyl 2-naphthyl ketone to (R)-(--)-2-isopropylamino-1-(2-naphthyl)ethanol and related reductions.


Resolution and reconstitution of the mitochondrial electron transport system. IV. The reconstitution of rotenone-sensitive reduced nicotinamide adenine dinucleotide-ubiquinone reductase from reduced nicotinamide adenine dinucleotide dehydrogenase and phospholipids.


A study of the conformational requirements for direct adrenergic stimulation.


Quaternary salts of substituted 2-aminoethyl N-benzoylaminobenzoate. A new class of smooth muscle relaxant agents.


Conformationally restricted analogs of histamine H1 receptor antagonists. Trans- and cis-1,5-Diphenyl-3-dimethylaminopyrrolidine.


Synthesis and inhibitory activity of new ethylenedioxyquinones as analogs of coenzyme Q.


Diphtheria as a model. Introduction of serums and vaccines for scarlet fever and pneumococcal pneumonia.


Medical education in the United States, 1972-1973.


Lipogenesis in the ruminant: effect of fasting and refeeding on fatty acid synthesis and enzymatic activity of sheep adipose tissue.


The European Environmental Mutagen Society. Abstracts of papers presented at the Third Annual Meeting, June 4th-7th, 1973. The Biomedical Centre, University of Uppsala (Sweden).


Rheumatologic disorders due to immune complexes.


Vesta variant of Tourette's disease: treatment with haloperidol.


Bacterial inhibition of ureteral smooth muscle contractility: in vitro evaluation of potential inhibitory factors.


Dehydrogenases in the prepubertal rat ovary: a histochemical study of delta-5-3 beta-hydroxysteroid dehydrogenase and enzymes of carbohydrate oxidation following oxythiamine treatment.


Drug metabolism and drug-induced spectral interactions in human fetal liver microsomes.


Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism.


Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.


Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. I. Pipecolic acid and slaframine biogenesis.


Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. II. The origin of pipecolic acid.


A year of continuing introspection, 1972-73.


The reduction of vinyl side-chains of Mg-protoporphyrin IX monomethyl ester in vitro.


Studies on rat-liver microsomal cholesterol 7alpha-hydroxylase.


NADP-linked isocitrate dehydrogenase from beef liver. Purification, quaternary structure and catalytic activity.


BC-105--a new prophylactic agent for migraine--four years' experience in seventy-five patients.


A new look at respiratory stimulants.

A new look at respiratory stimulants.


Electron transfer from alpha-reduced nicotinamide adenine dinucleotide to flavoprotein, cytochromes, and mixed function oxidases of rat liver microsomes.


The dental health of Indian children in the Sioux Lookout Zone of Northwestern Ontario.


A comparison of gas-liquid chromatographic retention indices on support-coated open tubular columns and on packed columns for a series of central nervous stimulant drugs.


The effect of vitamin B12 deprivation on the enzymes of fatty acid synthesis.


N-substituted 2-amino-1-(2-thienyl)ethanols as beta-adrenergic blocking agents.


Benzhydryl and fluorenyl lactamimides with hypoglycemic, diuretic, blood platelet aggregation inhibitory, and antiinflammatory activities.


Glutaryl-S-(p-bromobenzyl)-L-cysteinylglycine. A metabolically stable inhibitor of glyoxalase I.


Haemagglutination-inhibiting antibodies against arboviruses in animal sera, collected in some regions in Austria. II.


The occurrence of three different lipopolysaccharide cores in shigella and their relationship to known enterobacterial core types.


The pathogenicity of Listeria monocytogenes.


Differential media in the isolation of Listeria monocytogenes.


Nation-wide survey of antibiotic resistance by means of a computer.


Treating sleep disorders.

Treating sleep disorders.


Serum inorganic fluoride concentrations during and after halothane, fluroxene, and methoxyflurane anesthesia in man.


Dirofilaria immitis. A cause of pulmonary coin lesions in human beings.


Accuracy of gas standards used for mayo vapor analyzer calibration.


Respiratory tract infections in children. B. Lower respiratory tract disease.


Caries prevention by daily fluoride mouthrinsing. Report of a three-year clinical trial.


Potentiation of therapeutic effects of nicotinic acid by pyridoxine in chronic schizophrenics.


Clomipramine HCL--a double-blind study of a new antidepressant drug.


Comparison of the effects of fluoride drinking water on caries frequency and mottled enamel in three similar regions of Austria over a 10-year period.


Thrombophlebitis migrans. An unusual presentation as a collagen vascular disease--report of a case.


Model dehydrogenase reactions. Reduction of N-methylacridinium ion by reduced nicotinamide adenine dinucleotide and its derivatives.


The computer in family practice.

The computer in family practice.


Open-closed-mindedness and the physician's assistant: an exploratory study.


Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.


Combined treatment of hypertension with vasodilatation and beta-adrenergic blockade.


Meeting the dental treatment needs of indigent rural children.


Insecticidal activity of recent bacterial isolates and their toxins against mosquito larvae.


5-Hydroxytryptophan-induced myoclonus in guinea pigs and the possible role of serotonin in infantile myoclonus.


Effects of various depressant drugs on deprivation-induced water consumption.


Drug-induced catalepsy as influenced by convulsant and anticonvulsant drugs.


The relative importance of dopaminergic and noradrenergic neuronal systems for the stimulation of locomotor activity induced by amphetamine and other drugs.


The effect of a beta-blocker on plasma renin activity of hypertensive patients.


Pennsylvania success story. Physician expander concept passes test.


Transduction among group A Streptococci: transducibility of strains representative of thirty different M types.


Assimilation of guanidoacetic acid by Sporothrix schenckii.


A new primary-care medical practitioner.


Herniography: a diagnostic refinement in the management of cryptorchidism.


Practolol blockade of cardiac but not vascular or uterine beta-adrenergic receptors in the anesthetized cat.


Systemic and renal hemodynamic effects of a new alpha-adrenergic blocking agent: NC 7197.


On the lipid mobilization induced by oxyfedrine in the dog and the rat.


Fine control of citrate synthase activity in blue-green algae.


Antagonism of the effects of purinergic nerve stimulation and exogenously applied ATP on the guinea-pig taenia coli by 2-substituted imidazolines and related compounds.


Myocardial reactive hyperemia and coronary vascular reactivity in the dog.


Revised normal ranges for six serum enzymes: further statistical analysis and the effects of different treatments of blood specimens.


Subjective symptoms of acute asthma within a heterogeneous sample of asthmatics.


Five years observation on the dental caries experience of the "Saisiat" tribe aboriginal children in Taiwan.


Effects of axonal injury on norepinephrine, tyrosine hydroxylase and monoamine oxidase levels in sympathetic ganglia.


Dopaminergic neurons in explants of substantia nigra in culture.


The rapid differential diagnosis of meningitis.


A clinical evaluation of a stannous fluoride and a sarcosinate dentifrice.


Selective inhibitor of slow reacting substance of anaphylaxis.


Prevalence of dental caries in twins.

Prevalence of dental caries in twins.


A revision of the subfamily Haplorchinae Looss, 1899 (Trematoda: Heterophyidae). II. Genus Galactosomum.


Temperature-dependent toxicity of adrenegic agonists in mice as a basis for treating d-amphetamine poisoning.


The effect of alpha adrenergic block on adenosine- and ATP-induced coronary vasodilation.


Influences of splanchnic blood flow on epinephrine-induced hyperkalemia.


Glutamate dehydrogenase--ligand complexes and their relationship to the mechanism of the reaction.


A method for assaying activity and some other properties of NADP-oxidoreductase from Rhodotorula mucilaginosa.


Enhancement of hepatic tyrosine aminotransferase induction in the rat by 5-fluorouracil.


Epimerization of an intermediary metabolite of norethynodrel by a 3 beta-hydroxy-delta 5(10)-steroid epimerase.


Structure-activity relationships on the induction of hepatic microsomal enzymes in the mouse by 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane(DDT) analogs.


Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations.


The need for treatment in 11 to 17-year-old children. A longitudinal epidemiological study.


Development of cardiovascular responses to autonomic blockade in intact fetal and neonatal lambs.


Fluoride in the prevention of dental caries. A tentative cost-benefit analysis.


Fluoridation of domestic salt after three years.


Observations on the postmortem histochemistry of myofibers from stress susceptible pigs.


Effect of biliary obstruction on formation and metabolism of bile acids in rat.


11-dehydrocorticosterone (compd. A) formation by the Microtus adrenal.


Determinations of amino acid, cation and reduced glutathione levels in the red cells of Awassi sheep (Qvis aries).


Phosphate excretion in the laying fowl.

Phosphate excretion in the laying fowl.


Thermoregulatory responses of the arid zone kangaroos, Megaleia rufa and Macropus robustus.


Respiration of some urodele and anuran amphibia. I. In water, role of the skin and gills.


Effect of various gastrointestinal hormones and vasoactive substances on villous motility.


Rate of digestion in Ophiocephalus punctatus Bloch.


Some alterations in hemolymph proteins of Hemigrapsus nudus associated with temperature acclimation.


Effects of estradiol and testosterone on cyclic AMP levels in certain tissues of domestic fowl (Gallus domesticus).


Occupational, accidental, explorational carbon dioxide inhalation poisonings, and prevention.


Respiration of some urodele and anuran amphibia. II. In air, role of the skin and lungs.


Galactose toxicity in chick cells in vitro.


Lysine transport in turtle ventricle. I. Effect of ouabain and extracellular ions on lysine accumulation.


On the tongue of a hummingbird: its role in the rate and energetics of feeding.


Lysine transport in turtle ventricle. II. Effect of extracellular ions and ouabain on lysine fluxes.


Plasma volume changes in ground squirrels during water deprivation.


Carotenoid pigments in goldfish (Carassius auratus L.). VI. The effect of ACTH and phenylthiourea on the discoloration and the carotenoid metabolism.


II. Enhancement of the catalytic activity of the human placental 17 beta-oestradiol dehydrogenase by carboxymethylation of an histidyl residue of the active site.


[Impression on the 15th International Congress of Nursing in Mexico. Interview with Ms. Pumie Kobayashi, President of the Japan Nursing Association].


Vasodilatation in the nasal mucosa of the cat and the effects of parasympatholytic and beta-adrenergic blocking agents.


Population density and social pathology in mice. Differences in catecholamine metabolism associated with differences in behavior.


The insect-repellant value of Ocimum SPP. (Labiatae): traditional anti-mosquito plants.


Training the family nurse practitioner.

Training the family nurse practitioner.


Involvement of the alpha-adrenergic receptor in the phospholipid effect in rat parotid.


Bronchogenic cyst.

Bronchogenic cyst.


Are you satisfied with your CME?

Are you satisfied with your CME?


Letter: Some effects of irradiation and delayed amputation upon regeneration in Tubularia crocea.


Conformation of pyridine nucleotides studied by phosphorus-31 and hydrogen-1 fast fourier transform nuclear magnetic resonance spectroscopy. III. Oxidized and reduced dinucleotides.


Time orientation in the positive and negative free phantasies of mildly abnormal versus normal high school males.


The sored horse and the Horse Protection Act of 1970.


Pharmacology. New discoveries and the sympathetic nervous system.


Curvilinear trends in outcome research.

Curvilinear trends in outcome research.


Pleasant activities and depression.

Pleasant activities and depression.


Factor structure of the MMPI-168 in a psychiatric population.


Effects of mosquitoes on the average daily gain of Hereford and Brahman breed steers in southern Louisiana.


Potential histamine H2-receptor autagonists. 1. Aminoethylimidayo(1,2-a)pyridines and -imidayo(1,5-a)pyridines.


Potential bioreductive alkylating agents. 2. Antitumor effect and biochemical studies of naphthoquinone derivatives.


Beta-adrenoceptor blocking agents. 1. Cardioselective 1-aryloxy-3-(aryloxyalkylamino)propan-2-ols.


Nitrofuryl heterocyclics. 3.

Nitrofuryl heterocyclics. 3.


Antimetabolites of coenzyme Q. 20. Synthesis of new alkyl-5,8-quinoxalinequinones as potential inhibitors of coenzyme Q and as antimalarial drugs.


The erythroid cells and haemoglobins of the chick embryo.


Fluorouracil effect on cytochrome c reductase activity of rat liver cell endoplasmic reticulum following partial hepatectomy.


Relationship of racetrack surface to lameness in the thoroughbred racehorse.


Effects of the immunosuppressant methotrexate in ponies.


Abdominoscrotal hydrocele.

Abdominoscrotal hydrocele.


Role of the redox state of nicotinamide adenine dinucleotides in the in vivo regulation of inositol biosynthesis in Neurospora crassa.


International group agrees to write world cancer standard.


The WIRL-3 rat liver cell lines and their transformed derivatives.


Comparative dependence on adrenergic neural tone by automaticity in the sinus node and in the atrioventricular junction.


Coronary and myocardial effects of dopamine in the conscious dog: parasympatholytic augmentation of pressor and inotropic actions.


Communication in health.

Communication in health.


Transient bactericidal defect of peripheral blood phagocytes from children with acute lymphoblastic leukemia receiving craniospinal irradiation.


Contribution to the study of digestion in ticks: histology and fine structure of the midgut ephithelium of Ornithodorus moubata, Murray (Ixodoidea, Argasidae).


Mesenteric arteritis with extensive intestinal gangrene.


Structure and function of the basal lamina and of the cell junctions in the midgut epithelium (stomach) of female Aedes aegypti L.(Insecta, Diptera).


Reproductive biology of Eonycteris spelaea, Dobson (Megachiroptera) in West Malaysia.


The persistence of smallpox in remote unvaccinated villages during eradication program activities.


Detection of malarial antibodies in man by fluorescent antibody test using Plasmodium gallinaceum as antigen.


New animal reservoirs of T. rhodesiense sleeping sickness.


The effect of cordycepin on tsetse-borne Trypanosoma vivax infections.


The effect of beta-blockade on coronary and systemic circulation in dogs at rest and during adaptation to exercise.


The effect of autonomic blocking agents on the cardiovascular response to etoxadrol (CL 1848). I. Ganglionic blockade.


Thymoxamine on the guinea-pig vas deferens: an effect unrelated to alpha-receptor blockade.


The effect of autonomic blocking agents on the cardiovascular response to etoxadrol (CL 1848). II. Beta adrenergic blockade.


Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea.


Co-purification of three folate enzymes from porcine liver.


A branching reaction mechanism of glutathione reductase.


Catalytic activity and EPR signals of DPNH dehydrogenase in relation to the acquisition and loss of piericidin sensitivity and of coupling site 1.


Desaturation of phosphatidylcholine and phosphatidylethanolamine by a microsomal enzyme system from Candida lipolytica.


Reduced nicotinamide-adenine dinucleotide-nitrite reductase from Azotobacter chroococcum. 1. The assimilatory nitrite reductase of the N(2)-fixing bacterium Azotobacter chroococcum was prepared in a soluble form from cells grown aerobically with nitrate as the nitrogen source, and some of its properties have been studied. 2. The enzyme is a FAD-dependent metalloprotein (mol.wt. about 67000), which stoicheiometrically catalyses the direct reduction of nitrite to NH(3) with NADH as the electron donor. 3. NADH-nitrite reductase can exist in two either active or inactive interconvertible forms. Inactivation in vitro can be achieved by preincubation with NADH. Nitrite can specifically protect the enzyme against this inactivation and reverse the process once it has occurred. 4. A. chroococcum nitrite reductase is an adaptive enzyme whose formation depends on the presence of either nitrate or nitrite in the nutrient solution. 5. Tungstate inhibits growth of the microorganism very efficiently, by competition with molybdate, when nitrate is the nitrogen source, but does not interfere when nitrite or NH(3) is substituted for nitrate. The addition of tungstate to the culture media results in the loss of nitrate reductase activity but does not affect nitrite reductase.


Cognitive functioning and degree of psychosis in schizophrenics given many electroconvulsive treatments.


In vitro steroidogenesis in feline testes.


Radiotelemetry of cardiovascular responses to exercise and diving in penguins.


Trimodal gas exchange in the large aquatic salamander, Siren lacertina (Linnaeus).


Transport of some non-electrolytes through amphibian skins.


The effects of valinomycin on striated muscles of the frog and the crayfish.


Specific effect of bull seminal ribonuclease (AS RNase) on cell systems in mice.


Effect of temperature upon cell division, RNA and protein synthesis of cultured fathead minnow cells.


An estimate of the heat balance of a nesting hummingbird in a chilling climate.


Carbonic anhydrase activity in Arenicola marina (L.).


Utilization of dietary urea by the kangaroo island wallaby Protemnodon eugenii (Desmarest).


The lactate dehydrogenase isozymes of Coregonus hoyi gill (Pices: Salmonidae): tissue distribution, immunochemistry and molecular weight.


Interspecific variation in the levels of intestinal alkaline phosphatase, adenosine triphosphatase and disaccharidases.


The effects of anoxia on the respiratory movements of the hatching chick.


Psychotropic drug-induced transformations of visual space.


The effect of iron deficiency on respiration and energy-coupling in Escherichia coli.


Terminal respiration in Moraxella lwoffi (NCIB 8250).


Bacterial attack on phenolic ethers. Resolution of a Nocardia O-demethylase and purification of a cytochrome P 450 component.


Effects of hyperoxia on oxidized and reduced NAD and NADP concentrations in Escherichia coli.


The actions of drugs on the smooth muscle of the capsule and blood vessels of the spleen.


The second-class doctor and the medical assistant in South Africa.


A potential new method of identifying animal species and mosquito blood meals by the haemoglobin crystallization technique.


The biting cycles of Mansonia bonneae, M. dives, M. indiana and M. uniformis in Southern Thailand.


Reduction of ketones in liver cytosol.

Reduction of ketones in liver cytosol.


Azo reduction of salicyl-azo-sulphapyridine in germ-free and conventional rats.


Comparative oxidative metabolism of aflatoxin B1 and palmotoxins B0 and G0 by rat liver microsomal fractions.


Redox potential in caecal contents of the rat and azo reduction of salicyl-azo-sulphapyridine.


The colitis of Behcet's disease: a separate entity? Colonoscopic findings and literature review.


Regulation of nitrate reductase of Neurospora at the level of transcription and translation. The presence of nitrate is required for the induced synthesis of NADPH-nitrate reductase and its related partial activity Benzyl Viologen-nitrate reductase in a wild-type strain of Neurospora. In nit-3, a mutant lacking complete NADPH-nitrate reductase activity but retaining the partial activity Benzyl Viologen-nitrate reductase, the presence of nitrate ions is not required for the de-repressed synthesis of the latter enzyme. The accumulation of the capacity to synthesize nitrate reductase, and the related Benzyl Viologen-nitrate reductase, in the absence of protein synthesis does not require nitrate in the normal strain or in strain nit-3. Ammonia antagonizes the accumulation of this capacity in both strains. Nitrate is required for the synthesis of nitrate reductase and related activities from presumedly preformed mRNA in the wild-type strain. Nitrate is not required for the comparable function in strain nit-3. Ammonia appears to stop the synthesis of nitrate reductase and related activities from presumedly preformed mRNA in the wild-type strain and in strain nit-3. The effects of nitrate, or ammonia and of no nitrogen source on the induced synthesis of nitrate reductase cannot be explained on the basis of the effects of the different nitrogen sources on general synthesis of RNA or of protein.


Intersexual problems.

Intersexual problems.


The relationship between skin structure and transepidermal water loss.


Factors affecting plasma ceruloplasmin activity in Gallus domesticus.


Erythrocyte 2,3-diphosphoglycerate in normal and porphyric fetal, neonatal and adult cattle.


Temperature regulation in the platypus, Ornithorhynchus anatinus (Shaw).


Tissue glycogen levels in the Weddell seal, Leptonychotes weddelli: a possible adaptation to asphyxial hypoxia.


Role of hepatic glycogenolytic enzymes in the cold-induced hyperglycemia of the killifish, Fundulus heteroclitus.


Effects of temperature, photoperiod and season on in vitro metabolic rates of tissues from Thamnophis sirtalis parietalis, a cold climate reptile.


The effect of salinity and temperature on the heart rate of osmoregulating and osmoconforming shrimps.


Water content and distribution of tritiated water in tissues of Australian desert rodents.


The responses of three species of bivalve mollusc to declining oxygen tension at reduced salinity.


Influence of seasonal temperatures on the energy budget and metabolic rates of the northern two-lined salamander Eurycea bislineata bislineata.


Critical thermal maxima of turtles: validity of body temperature.


Amine excretion in excysted larvae and adults of Trichinella spiralis.


British usage and American awareness of some new therapeutic drugs.


Effects of acclimation on metabolic rate and thermal tolerance in the carpenter frog, Rana vergatipes.


Sodium uptake by the sailfin molly, Poecilia latipinna: kinetic analysis of a carrier system present in both fresh-water-acclimated and sea-water-acclimated individuals.


Daily and seasonal variation in metabolic response to cold during rest and forced exercise in the common redpoll.


Partial characterization of the thyroid proteinase of the burbot, Lota lota L.


The effect of imipramine on in vitro dog bladder muscle contractility.


Death induced by injection stress in cold-acclimated goldfish, Carassius auratus.


Implants and transplants: review of recent research in this area of oral surgery.


The effects of pregnancy, lactation and involution on the metabolism of glucose and acetate by rat liver tissue.


Beta-Adrenergic blocking agents. Nitrogen heteroaryl-substituted 2-propanolamines and ethanolamines.


Item level racial differences on the MMPI.


The treatment of hemorrhagic shock with WR-149,024 (1,18-diamino-6,13-diaza-9,10-dithiaoctadecane tetrahydrochloride).


Lipid peroxidation in spermatozoa.

Lipid peroxidation in spermatozoa.


Adenosine 3':5'-cyclic monophosphate in relation to motility and senescence of spermatozoa.


Electrogenic sodium pump in pancreatic acinar cells.


Spontaneous action potentials in isolated guinea-pig cerebellar slices: effects of amino acids and conditions affecting sodium and water uptake.


Inhibition by actinomycin D of the denervation-induced action potential in frog slow muscle fibres.


The growth of tumours in T-cell deprived mice and their response to treatment with Corynebacterium parvum.


Proceedings: Study of enzyme induction in epileptic children.


Is phenobarbital a "gratuitous" inducer in male rats?


Anticonvulsant effect of 5-ethyl,5-phenyl,2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.


The effects of vitamin C on the relationship between leucocyte and plasma ascorbic acid concentrations and the blood glutathione concentration.


The metabolism of palmitic, stearic, oleic and linoleic acids in broiled chickens.


Welcome address: 48th All-India Medical Conference.


The younger physician speaks.

The younger physician speaks.


The winds of change.

The winds of change.


Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro.


Further evidence for the heterogeneous storage of noradrenaline in central noradrenergic terminals.


Reactivity of arteries to neurohormones in experimental vibration.


Masculinity-femininity: an exception to a famous dictum?


Central nervous alpha-adrenergic receptors and the mode of action of alpha-methyldopa.


Pharmacological backgrounds of drug interaction.


Induction of hepatic tyrosine aminotransferase by tyrosine-copper(II)-complex.


Preliminary characterization of an inhibitor of drug metabolism released in response to cyclic adenine nucleotides.


The developmental localization of macromolecular groups in selected stages of Hydractinia echinata.


Hereditary influence on the normal personality using the MMPI. II. Prospective assortative mating.


Common origin for all neuroendocrine tumors.


Multiple forms of glutamine synthetase. Hybrid formation by association of adenylylated and unadenylylated subunits.


Identification of the product excited states during the chemiluminescent and bioluminescent oxidation of Renilla (sea pansy) luciferin and certain of its analogs.