Two fatal cases of septicaemia due to Erysipelothrix insidiosa. Clinical, pathological, and necropsy findings are recorded from two cases of endocarditis due to Erysipelothrix insidiosa, one in a 53-year-old grocer and the other in a 56-year-old housewife. The possible sources of infection are suggested.


A differential staining method for intestinal ova and larva.


The applicability of anaphylactic tests in studies of antigen mixtures. I. The sensitivity of the tests.


The applicability of anaphylactic tests in studies of antigen mixtures. II. The discriminatory capacity of the tests.


Successive cresylviolet and hematoxylin staining.


Characterization of the antibodies responsible for the 'bactericidal activity patterns' of antisera to Bordetella pertussis.


Oxygen consumption during histamine release by antigen and compound 48/80.


Effect of anoxia, glucose and thioglycollate on anaphylactic and compound 48/80-induced histamine release in isolated rat mast cells.


Studies on the enzymatic systems of rat adrenals in the early postnatal period: hydroxylation of progesterone-4-C-14, NADP-linked dehydrogenase activity and reduced pyridine nucleotides content.


Isolation of anti-dinitrophenyl group antibodies with a triply substituted cross-reacting antigen.


EEG findings in an infant with water intoxication and convulsions incident to hypernatraemia.


Preparation and characterization of poly-DL-alanyl rabbit gamma-globulin.


Immunoglobulin studies in six kindreds of patients with adult hypogammaglobulinemia.


Intestinal lipodystrophy (Whipple's disease). Demonstration of anatomic alteration before onset of symptoms.


Isolation of lipoproteins from thyroxine-labeled human serum.


The cytology and histochemistry of the digestive gland cells of Helix.


Antagonistic and antidotal action of vitamins K1 and K3 versus dicumarol in dogs.


Radioautographic studies of poliovirus binding by human immunoglobulins.


Inhibition of interferon action by actinomycin.


Antigenic differences and similarities of the gamma-globulins of certain mammals.


Low-fat diet in myocardial infarction: A controlled trial.


Blood-sugar and arterial disease.

Blood-sugar and arterial disease.


Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide.


The shocked head injury.

The shocked head injury.


Prognosis of cerebral embolism.

Prognosis of cerebral embolism.


Intestinal biopsy in kwashiorkor.

Intestinal biopsy in kwashiorkor.


Post-gastrectomy bile vomiting.

Post-gastrectomy bile vomiting.


An operation for facilitating external pacing of the heart in long-term treatment of heart-block.


Making sense of turner's syndrome.

Making sense of turner's syndrome.


Prevention of isopropanolamine of kwashiorkor-type fatty liver in threonine-deficient rats.


Glycogen myopathy in adults.

Glycogen myopathy in adults.


Temperature recording in a teaching hospital.


Group therapy for alcoholism.

Group therapy for alcoholism.


Halothane.

Halothane.


Haemothorax and osteomalacia.

Haemothorax and osteomalacia.


Amitriptyline poisoning.

Amitriptyline poisoning.


Effect of propranolol in myocardial infarction.


Plasma-growth-hormone levels in untreated acromegaly and after radioactive implants into the pituitary.


Treatment of collagen diseases with cytostatics.


Chromosome studies on randomly chosen men and women.


Serum-pseudocholinesterase in depression with notable anxiety.


Heights and weights of middle class Baganda children.


Hydroxyproline creatinine ratio as an index of nutritional status and rate of growth.


A new remotely controlled unit for the treatment of uterine carcinoma.


Inhibition of lactate dehydrogenase by sera of uraemic patients.


Test for pituitary function using vasopressin.


Automatic measurement of lung function.

Automatic measurement of lung function.


Improved short hip-spica cast.

Improved short hip-spica cast.


A skeleton in our body-fat cupboard?

A skeleton in our body-fat cupboard?


Measuring blood sugar.

Measuring blood sugar.


Electromyography in thyrotoxic myopathy.


Leprosy undefeated.

Leprosy undefeated.


Use of modern physical techniques to examine obliterated case-records.


A comprehensive psycho-geriatric service.


Bladder tumours in industry.

Bladder tumours in industry.


Tetracyclines in tumour tissues.

Tetracyclines in tumour tissues.


Glucagon antibodies.

Glucagon antibodies.


Carcinoma of bronchus.

Carcinoma of bronchus.


Potassium chloride and intestinal ulceration.


Agronomy and health. The marriage of agriculture and medicine.


Fluorescein fundus photography in the detection of early papilloedema and its differentiation from pseudo-papilloedema.


New preparations for oral iron-therapy.

New preparations for oral iron-therapy.


Chloroquine-resistant falciparum malaria in Thailand.


Acid-base status assessed from measurements of hydrogen-ion concentration and PCO2.


Carbohydrate metabolism in kwashiorkor.

Carbohydrate metabolism in kwashiorkor.


Two Ph1 chromosomes in acute granulocytic leukaemia. A study of two cases.


Effect of arginine on serum-levels of human growth-hormone.


Deficiency of erythrocyte galactokinase in a patient with galactose diabetes.


Training for development.

Training for development.


Gamma-globulin prophylaxis of hepatitis.


Order in the medical record.

Order in the medical record.


Resistance to chloroquine.

Resistance to chloroquine.


The newcomers. A visitor's views.

The newcomers. A visitor's views.


Design of operating-room dress for surgeons.


M.B. and M.D. A plea for rationalisation.


Haemolytic anaemia due to nalidixic acid.


Effect of bilateral glossopharyngeal nerve section on blood pressure. A case report.


Treatment of rheumatoid arthritis with immunosuppressive drugs. I. Clinical study.


Heart disease detection in school children. Evaluation of heart sound tape-recordings as a mass screening method.


Nitro-oolefins as potential carcinogens in air pollution.


Treatment of chronic portal-systemic encephalopathy by surgical exclusion of the colon.


Influence of iodine intake after treatment with antithyroid drugs.


Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome.


Vagal stimulation of gastric secretion in man by 2-deoxy-D-glucose.


Serum-proteins in the idiopathic respiratory-distress syndrome of the newborn.


Antibody to smooth muscle in patients with liver disease.


Fibrosis in guineapig heart produced by plantain diet.


In-vivo method for detecting antimony deposits in the lung by differentiated absorption of x-radiation.


Surgery of the chronic ear.

Surgery of the chronic ear.


A fatty acid characteristic of a deficiency of linoleic acid in a case of hepatoma.


Pharmacologically active and lethal substances from skin.


Regulation of the rate of synthesis of messenger ribonucleic acid by growth hormone.


Concentrations of glycerol and non-esterified fatty acids in plasma during fat mobilization.


Activation of palmityl-coA: carnitine palmityltransferase in livers from fasted, fat-fed, or diabetic rats.


Hydrocephalus and its various subtypes.

Hydrocephalus and its various subtypes.


Experiences with the ventriculo-atrial shunt operation for hydrocephalus.


Intracranial arteriovenous malformation.


Intracranial arterio-venous malformation with special reference to its treatment.


Experimental transplantation of the head--two headed dog.


Aggravation of hepatic lesions in mice by in vivo localization of immune complexes (Auer hepatitis).


Serum glycoproteins and proteins after fractures.


Evaluation of a cellulose-acetate electrophoresis system for serum protein fractionation.


Acetabularia.

Acetabularia.


The rabbit flea and hormones.

The rabbit flea and hormones.


Diagnosis of the adrenogenital syndrome before birth.


The cerebrospinal fluid gamma-globulin profile in subacute sclerosing leucoencephalitis. An immuno-electrophoretic study.


Vital and supravital staining of peripheral nerve endings and motor endplates in biopsy material.


The value of CSF-analysis in the diagnosis of MS.


Multiple sclerosis classification scheme integrating clinical and CSF findings.


Double tracer methods in studies on blood-brain barrier dysfunction and brain edema.


The interaction between polysaccharides and other macromolecules. 9. The exclusion of molecules from hyaluronic acid gels and solutions.


Studies of particulate iodoproteins in the rat thyroid.


Mechanism of action of some antithyrotoxic substances.


Review of the Czechoslovak haematological literature published in the Czechoslovak journals in 1963. II.


Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy.


The local response in the guinea-pig to self and non-self proteins.


Studies on chemotaxis. I. On the chemotactic and complement-fixing activity of gamma-globulins.


Transendothelial passage of small and large molecules in inflamed skin.


Specific inhibition of antibody production. IV. Standardization of the antigen-elimination test; immunological paralysis of mice previously immunized.


Fractionation and characterization of proteins and lipids in bile.


The simultaneous occurrence of two different myeloma proteins.


Critical evaluation of 51-Cr-labelled serum albumin in the study of gastrointestinal protein loss.


Superior vena caval obstruction with carcinoma of the lung.


Therapy of experimental vaccinal keratitis. Effect of idoxuridine and VIG.


Estimation of the molecular weights of proteins by Sephadex gel-filtration.


Studies on antibody levels during vaccination of rhesus monkeys against Plasmodium knowlesi.


Whole antiserum versus the gamma-globulin fraction of antiserum in the indirect fluorescent antibody technique.


Transport of organic compounds in the mammal. Partition of dieldrin and telodrin between the cellular components and soluble proteins of blood.


The effect of some solutes on the velocity of the precipitin reaction.


Analysis of horse serum inhibitors of A2 influenza virus haemagglutination.


The reactivity of rheumatoid factor with human gamma G globulin.


The affinity of a mycobacterial glycopeptide for guinea-pig gamma-globulin.


The effects of antibodies on cells. 3. Studies on the interaction of rat liver mitochondria and lysosomes with antibody and complement.


Critical studies on determination of thyroid secretion rate in cold-adapted animals.


Immunochemical properties of human gamma-A isohemagglutinin. I. Comparisons with gamma-G and gamma-M-globulin antibodies.


Fluorescent antibody staining. 3. Preparation of fluorescein-isothiocyanate-labeled antibodies.


Chromatographic purification of tetramethylrhodamine-immune globulin conjugates and their use in the cellular localization of rabbit gamma-globulin polypeptide chains.


Frequency distribution of alpha, gamma, kappa and lambda polypeptide chains in human lymphoid tissues.


The stability of messenger ribonucleic acid in antibody synthesis.


Mercaptoethanol-sensitive antibody production in germ-free mice and guinea pigs.


Modification of self-imposed delay of reward through exposure to live and symbolic models.


Preparation and presentation of an inservice program.


Audio-visual resources.

Audio-visual resources.


The immunoglobulin sequence. I. Arrest by 6-mercaptopurine and restitution by antibody, antigen or splenectomy.


Surface structure of negatively stained membranes.


Anti-I antibody in normal human newborn infants.


Serum proteins of germ-free rats fed water-soluble diets.


Isolation of two benzocoumarins from 'clover stone' a type of renal calculus found in sheep.


Histochemistry of mucus and other polysaccharides in tumors. I. Carcinoma of the bladder.


Chemicals released as a result of antigen-antibody union.


The diagnostic significance of the parietal cell immunofluorescent test.


Release of permeability factors from the blood platelet.


Electrophysiological effects of different concentrations of circulating thyroid hormones on sympathetic ganglia.


The metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and gamma-hexachlorocyclohexane in rats. 1. After intraperitoneal administration, gamma-hexachlorocyclohexane (Gammexane) and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of gamma-hexachlorocyclohexane and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in gamma-hexachlorocyclohexane metabolism in rats.


Erythropoietic polyploidy. I. The morphology of polyploid erythroid elements and their incidence in healthy subjects.


Immunization of rhesus monkeys against Plasmodium knowlesi malaria.


Cot deaths.

Cot deaths.


Phentolamine.

Phentolamine.


Vaccination against cholera.

Vaccination against cholera.


Planned entry.

Planned entry.


New data on the embryo-specific antigenic components of human blood serum.


Isolation requirements for surgical units. A report to the Newcastle Regional Hospital Board by a working party from the North-East Region Pathology Advisory Committee.


A barrister's opinion on the terms of service.


Halothane.

Halothane.


Amphetamine.

Amphetamine.


Amitriptyline poisoning.

Amitriptyline poisoning.


Effects of anti-lobster nerve antibody on membrane potentials of the giant axon of Palinurus vulgaris.


Isolation and partial characterization of a pink pigment from normal human plasma.


Histochemical studies on the rabbit liver after intoxication with mercurial steams.


The nature of substrates stained with mordanted Weigert hematoxylin.


[PAS-positivity in the rat megakaryocytes].


A new tray for improved Giemsa staining of blood films.


Reconstitution of Helix pomatia haemocyanin with the copper (I) acetonitrile complex.


Specific acetylation of the exocyclic amino group of cytosine in cytidine, cytidylic acid and ribonucleic acid.


Aldosterone, a permeability hormone?

Aldosterone, a permeability hormone?


Suppression of unitary activity in the prepiriform cortex by activation of the olfactory bulbs.


Pacemaker potentials in left auricular tissue of the guinea pig.


Intracellular chloride concentration in cat papillary muscles. Influence of external K concentration.


Different types of asymmetric distribution of hydrosoluble and liposoluble substances at the two sides of a mucosal intestinal preparation.


Fibrillation in normothermic and hypothermic rabbit heart and effect of adrenaline.


Biosynthesis of unsaturated and saturated fatty acids in aseptically reared larvae of Calliphora erythrocephala (Meig.).


L-glutamic acid dehydrogenase activity in the gills of Palinurus vulgaris Latr.


Catecholamines plasma levels in the pulmonary artery, the pulmonary vein and the arterial tree of open-chest dogs during ambient air breathing and during acute anoxia.


University of Iowa, College of Medicine. Clinical pathologic conference.


Normal immunoglobulins and antibody response in neonatally thymectomized mice.


Effect of various agents on the developmental phases of the L strain cells in vitro.


Changes in metabolism of ribonucleic acid during the early embryonic development of the sea urchin.


Push-button system results in better patient care, improved patient confidence, more efficient utilization of staff.


Nature of endogenous reserve material in a strain of Pseudomonas fluorescens-putida intermediate.


The action of pepsin on protein fractions from horse antisera to diphtheria toxin.


A criterion for evaluating the number of capsomeres of icosahedral capsids.


Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus.


Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. II. Acute, subacute, and chronic glomerulonephritis.


A new acute phase protein elicited in mice by streptolysin O and other toxic or infectious agents. A new acute phase plasma component has been found in mice exposed to certain toxic materials and pathogenic bacteria. The abnormal component, detected by immunodiffusion employing absorbed antiserum, was chiefly studied in plasma of streptolysin O-treated mice where it appears within 24 hours after intravenous administration of a sublethal dose of the toxin. The new factor is a protein having the electrophoretic mobility of a slow alpha2-globulin. It is devoid of lipid and separate from the streptolysin O inhibitory lipoprotein that is also induced by administration of the streptococcal toxin. The factor, moreover, appears clearly distinct from haptoglobin or C-reactive protein and seems to be a unique type of acute phase protein. Its partial purification by starch block electrophoresis is described. A number of toxic materials other than streptolysin O, i.e. saponin, Cl. welchii phospholipase C (alpha-toxin), and endotoxins, were found to elicit the abnormal protein in mice. Phospholipase A (Crotalus adamanteus venom) and staphylococcal alpha-toxin failed to cause its appearance. Plasma samples of mice acutely infected with Group A streptococci, Staphylococcus aureus or pneumococcus uniformly contained the abnormal component. The significance of this acute phase protein has been considered in relation to the streptolysin O inhibitor and to the acute phase proteins of other animal species. It has been suggested that production of the new component and of the streptolysin O inhibitor may be manifestations of a single process constituting a physiological response to a variety of deleterious agents.


Phylogenetic origins of antibody structure. I. Multichain structure of immunoglobulins in the smooth dogfish (Mustelus canis). The elasmobranch Mustelus canis has been shown to produce antibodies to Limulus hemocyanin. The serum of both normal and immunized M. canis contains immunoglobulins having sedimentation coefficients of approximately 7S and 17S. Antibody activity was found in the 17S immunoglobulin which may be dissociated to 7S components with concomitant loss of activity. Both 17S and 7S serum, immunoglobulins were antigenically identical. They consisted of light and heavy chains present in amounts comparable to those of higher vertebrates. Peptide maps indicated that the light chains had an entirely different primary structure than the heavy chains, but that the corresponding chains of 7S and 17S dogfish serum immunoglobulins were similar in primary structure. The heavy chains appeared to resemble the n chains of immunoglobulins of higher vertebrates in their starch gel electrophoretic behavior. It is suggested that the elasmobranch M. canis may have only one major class of immunoglobulins resembling that of macroglobulins (gammaM-immunoglobulins) seen in higher vertebrates. The results indicate that the multichain structure of antibodies is an ancient evolutionary development.


Specificity of recombination of H and L chains from human gamma-G-myeloma proteins. Dissociated H and L chains of human gammaG-myeloma proteins were recombined by removal of conditions interrupting non-covalent interactions. In the process of recombination 7S molecules were formed. It was demonstrated that the H chains from individual gammaG-myeloma proteins recombine with their own L chains but also with L chains derived from other myeloma proteins. In some instances, however, the L chains from other myeloma proteins did not recombine as avidly with the H chains as the autologous L chains. The specificity of the non-covalent interactions of H and L chains was particularly well brought out by competitive recombination experiments where an individual H chain had a choice of recombining with its own L chain or with the L chain obtained from another myeloma protein. In this manner a spectrum of affinities between individual H chains and several L chains was demonstrated. In the vast majority of recombinations there was a clearcut preference for recombination to take place between the H and L chains derived from the same protein. It is postulated that this specificity is related to differences in the primary structure, which cause differences in configuration of these homogeneous H and L chains and that these configurations then dictate on thermodynamic grounds the pairing of H chains with particular L chains.


Properties of fluorescein-labeled human gamma globulin used in quantitative immunofluorescence tests.


A simple method for estimating isoelectric points.


Conversion of U-C14-phytol to phytanic acid and its oxidation in heredopathia atactica polyneuritiformis.


A slow and progressive action of cyanide on the anaphylactic reaction of guinea pig lung slices.


In vitro precipitation of liver microsomes by deptropine and some structurally related compounds: a cause for the discrepancies observed between in vivo and in vitro n-demethylation.


Thyroiditis.

Thyroiditis.


The transfusion of active LE plasma into nonlupus recipients, with a note on the LE-like cell.


The frequent occurrence of hypergammaglobulinemia and multiple tissue antibodies in Sjögren's syndrome.


Observations on antigamma globulin factors in human sera and antibodies against autologous gamma globulins produced in rabbits.


Some aspects of the relations between rheumatoid arthritis, antigamma-globulin factors and the polymorphism of human gamma globulin.


Inhibition of complement fixation by rheumatoid sera.


Antinuclear factors in rheumatoid arthritis.


Autoimmunity--experimental and clinical aspects.


The regeneration of the copper bands of aged Helix pomatia haemocyanin with hydrogen peroxide or cysteine.


The cause of the green polarization color of amyloid stained with Congo red.


Distribution of allelic allotypes among gamma-G-immunoglobulins and purified anti-hapten antibodies from the same rabbit.


The solubility and other physicochemical properties of human gamma-globulin labeled with fluorescein isothiocyanate.


Heterogeneity of sheep diphtheria and tetanus antibodies.


A new serum factor in normal rabbits. I. Identification and characterization.


Persistent altered phenotypic expression of allelic gamma-G-immunoglobulin allotypes in heterozygous rabbits exposed to isoantibodies in fetal and neonatal life.


Immunochemical study on rat urinary proteins: their relation to serum and kidney proteins (chromatographic separation of the major urinary protein).


Reactivity of rheumatoid factor with rabbit gamma-globulin.


Effect of hypothermia on systemic anaphylaxis: limitations of cold protection.


An albumin and gamma-globulin characteristic of bovine cerebrospinal fluid.


The aggregation of gamma-myeloma proteins.


Inhibition of antibody production and acquired immunologic tolerance by actinomycin.


A comparison of serum L-asparatate: 2-oxoglutamate aminotransferase activity in the normal and tympanitic bovine.


Cytochemical observations on beta-thalassaemia. I. The PAS positive substance of erythroblasts.


Metabolism of gammaG-globulin in chronic leukaemia.


Cholinesterase in the cat cerebellar cortex, deep nuclei and peduncles.


Studies of the control of thyroid function in rats: effects of salicylate and related drugs.


Further evidence of the existence of differences in the mechanism of immune cellular injury of sheep erythrocytes and rat mast cells.


Syndrome of juvenile hypothyroidism associated with advanced sexual development: report of two new cases and comment on the management of an associated ovarian mass.


Testicular intratubular bodies.

Testicular intratubular bodies.


Value of urine and serum hydroxyproline in the diagnosis of thyroid disease.


Influence of tapazole upon serum TSH.

Influence of tapazole upon serum TSH.


Chemotactic response of polymorphonuclear leukocytes to Trichinella spiralis and Ascaris suum extracts.


Antigen analysis of sera from patients with malignant tumors by immunodiffusion methods.


Refsum's syndrome with corneal involvement.


Repetitive self-observation by videotape playback.


"Endemic coast goitre" in Hokkaido, Japan.


Electron affinity and animal toxicity of benzene hexachloride isomers.


Significance of histamine in enhancement of contractile tension during the atrial anaphylaxis.


On the use of fluorescein and dichlorofluorescein as non-destructive stains for lipids.


The major component of metin from rabbit skeletal and bovine cardiac muscle.


Relative labilities of the two types of interchain disulfide bond of rabbit gamma G-immunoglobulin.


Oxidative phosphorylation in fractionated bacterial systems. 18. Phosphorylation coupled to different segments of the respiratory chains of Mycobacterium phlei.


Current status of measles immunization.

Current status of measles immunization.


The immunological response of the neonatal and suckling cat to various antigens administered parenterally or orally.


Hepatic vasculature and cell proliferation in experimental cirrhosis.


The response of mast cells to compound 48/80 studied with the electron microscope.


Process analysis: a tool in understanding ambiguity in diagnostic problems in Rorschach.


Carcinoma of the middle ear.

Carcinoma of the middle ear.


On the capacity of pepsin-digested antibody to neutralize adenovirus infectivity.


Cell resistance induced by virus--antibody complexes.


Studies of blood groups, immunoglobulins and isoagglutinins in multiple myeloma and various hematological disorders in the Honolulu area.


Disc electrophoresis of rat plasma lipoproteins. The disc electrophoresis of lipoproteins of unfractionated rat plasma is described. The plasma was prestained with Sudan black B and electrophoretically separated at polyacrylamide gel concentrations of 7.5, 5, and 3.75%. At least four lipoprotein components were observed, and an additional 2-3 components in the main gel and 2-5 components in the spacer gel possibly were present. Densitometry of the resolved gel patterns indicated good reproducibility. Thin-layer chromatography of lipids extracted from the Sudan black B-binding components confirmed the lipoprotein nature of these components of rat plasma. A comparison of the disc electrophoretic patterns of human serum and rat plasma suggested that the low-density lipoprotein components of rat plasma are smaller in size than those of human serum.


Permanent sensitive stain for choline-containing phospholipids on thin-layer chromatograms. The phosphomolybdic blue stain for choline of Levine and Chargaff can be used for detection of small amounts of choline-containing phospholipids on thin-layer chromatograms if they are first fixed with polyvinyl propionate to permit a washing step.


Effect of two blood plasma protein fractions on respiratory activity and cationic distribution of brain cortex slices in vitro.


Cytoplasmic inclusions and organelles of in vitro cultured Trypanosoma theileri and Trypanosoma melophagium and some speculations on their function.


Two types of cytoplasmic granule in Trypanosoma rhodesiense.


The obtaining, composition, and characteristics of alpha-1-globulin of hen blood serum.


Polysomes from microdissected fresh neurons.


Immunochemical semiquantitative estimation of gamma-M- and gamma-A-immunoglobulins in healthy and diseased children. 2. Immunoglobulin levels in nephrotic syndrome, exudative enteropathy, acute leukemia, and malignant tumors.


Immunochemical semiquantitative estimation of gamma-M- and gamma-A- immunoglobulins in healthy and diseased children. 1. Immunoglobulin levels from the newborn period to adulthood.


Histological distribution and nature of stainable lipids of the human endometrium.


Some effects of autologous and homologous blood or plasma overtransfusions in the dog.


Immunochemical detection of an acute-phase protein in rat serum.


The effect of prolonged oestrogen treatment of thyroid function in male rhesus monkeys.


Relationship between blood histamine and centrally evoked hypotensive response.


The effect of CSF paraproteins on the colloidal gold test.


Seasonal variation of PBI in healthy Montrealers.


Elevation of the acid phosphatase in benign prostatic disease.


Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II).


A clinical evaluation of the uroscreen test: triphenyltetrazolium chloride.


Fluorescence microscopy and other special procedures for diagnosis and study of mycotic infections.


Device for display of tape-recorded analog data.


Failure to confirm goitrogenic and hypercholesterolemic effects of uracil.


Hereditary variants of serum alpha-1-antitrypsin.


Breast cancer and hypothyroidism.

Breast cancer and hypothyroidism.


Acridine orange; an unsuccessful agent for radiologic localization of tumors.


The mechanism of hypertrophy and wear of the myocardium.


Correlation of cis- and trans-3-methylproline with (allo) isoleucine.


Fine structure of the cerebellum of children with lipidoses.


Comparison between radioiodine and antithyroid therapy in the management of hyperthyroidism.


Release of norepinephrine from isolated hearts by acetylcholine.


Study on inter-relationship between thyroid and parathyroid using in vitro bone calcium exchange method.


Jejunal biopsy in the diagnosis of malabsorption syndromes.


About a phosphodiesterase in Phaseolus aureus Roxb.


Waveform of electrodermal reactions in anesthetized cats.


Direct release of myocardial catecholamines into the left heart chambers.


The ionic composition of rat aortic smooth muscle fibres.


Kininergic transmission in a frog vagus-stomach muscle preparation.


Release of acetylcholine by the isolated rat heart atria and its influence on regulation of contractility by rhythm.


Albumin metabolism in rabbits during gamma globulin infusions.


Racial differences in serum gamma globulin levels: comparative data for Negroes, Puerto Ricans, and other Caucasians.


Silver impregnation of blood vessels in vivo.


The effect of decomplementation on delayed-type hypersensitive reactions to a conjugated antigen in rats.


Further attempts to characterize the normal incomplete cold antibody.


The use of cinefluorography in peripheral arteriography.


Evaluation of gamma globulin for prophylaxis against burn sepsis.


Nucleus of the adult polynuclear leucocytes of rodent and human blood stained with a modified Giemsa technique.


Histochemical studies on tibial growing cartilage in polyepiphysial dysplasia (Feirbank disease, Müller-Ribbing-Krankheit).


Changes of the content of phospholipids in the capsula interna of rats during ontogenesis.


The detection of heart disease in children. Results of mass field trials with use of tape recorded heart sounds. II. The Michigan City study.


Primary interaction with I-131-labeled antigens as an approach to detecting tuberculosis.


Lung cancer and environment: a study of long-term exposure to motor fumes in tunnels.


Submucosal mast cells and the enterchromaffin reactions.


Preparation of stained whole mounts of flatworms.


The use of I-131-albumin in assays of drugs that increase vascular permeability in the skin of guinea pigs.


Pentobarbitone-barbitone anaesthesia and thyroid function in the rat..


Augmentation by chlormadinone of the uterine weight response to human chorionic gonadotrophin in intact immature rats.


The present role of radiation therapy in the treatment of carcinoma of the lung.


Hematologic and biochemical indices in the East African baboon.


Fine structural localization of adenosine triphosphatase in human platelets and other blood cells.


Prolonged intra-arterial therapy for advanced pelvic malignancy.


Morphogenesis of prostatic carcinoma.

Morphogenesis of prostatic carcinoma.


The mechanism of origin of cortical convulsive potentials.


Neuronal responses in the cerebral cortex to electrical stimulation of the non-specific thalamic nuclei in cats.


The averaged electrical responses to diffuse and to patterned light in the human.


The visually evoked potential in twins.

The visually evoked potential in twins.


The electrocorticogram in the chronic cerveau isolé cat.


Pyramidal tract responses during seizures.


Comparative frequency distributions of large and small amplitude rhythms of the human electroencephalogram.


Average voltage as a measure of phase synchrony in the EEG.


Actinomycin synthesis in washed cells of Streptomyces antibioticus.


"Cryptothyroidism", the major cause of sporadic "athyreotic" cretinism.


Serum protein-bound iodine in obesity.

Serum protein-bound iodine in obesity.


Effect of increased dietary iodide on thyroid accumulation and secretion in euthyroid Arkansas subjects.


Immunochemical properties of human gamma A isoagglutinin. II. The effect of reduction and alkylation.


Adenovirus-antibody agglutination reactions.


Immunochemical and genetic studies of two distinct gamma-G-immunoglobulins in BALB-c mice.


Immunochemical studies on equine antibodies to human gamma-2-globulin.


Partial separation of skin-sensitizing antibody from antibodies which bind antigens in vitro.


Immunoglobulins in the skin of allergic and nonallergic individuals.


Effect of various fixatives on dissolution and staining characteristics of acid mucopolysaccharides in human aorta.


Protein turbidity produced by trichloracetic acid and sulfosalicylic acid at varying temperatures and varying ratios of albumin and globulin.


Chronic thyroiditis. A potentially confusing clinical picture.


Effect of ultraviolet irradiation on the acid-fastness and gram-positivity of mycobacteria.


Polynuclear aza compounds in automative exhaust.


The detection of heart disease in children. Results of mass field trials with use of tape recorded heart sounds. 3. The Chicago area high school study.


Evoked cortical response enhancement and attention in man. A study of responses to auditory and shock stimuli.


Effects of cardiac and respiratory cycles on averaged visual evoked responses.


EEG abnormalities and visual field deficits in flicker perception.


Changes in evoked brain oxygen during sensory stimulation and conditioning.


Conditioned reflexes elicited in squirrel monkeys by stimuli producing recruiting responses.


Possible role of hyperventilation in the CNS effects attributed to tubocurarine.


Circadian sleep and waking patterns in the laboratory cat.


The effect of imipramine, desmethylimipramine and chlorpromazine on the sleep-wakefulness cycle of the cat.


Steady potential shifts in the rat during desynchronized sleep.


On-line electroencephalographic digital computing system.


Acquisition of EEG data by bipolar, unipolar and average reference methods: a theoretical comparison.


Multiple electrode implantation in animals. A simplified plastic cap technique.


Carcinogenic nitrogen compounds. XLVII. Gamma-carbolines and 2,10-diaza-anthracenes isosteric with benzocarbazoles and benzacridines.


Quinazolines and 1,4-benzodiazepines. XXVII. Mechanism of ring enlargement of quinazoline 3-oxides with alkali to 1,4-benzodiazepin-2-one 4-oxides.


An electron microscope and cytochemical study of adenovirus in colchicine-induced, micronucleated, tissue-cultured cells.


Species specificity of the lupus erythematosus serum factor.


Hyperglobulinemic purpura terminating in myeloma, hyperlipemia, and xanthomatosis.


New method for studying peripheral circulation in man.


Out of the classroom: Tommy tunes in.

Out of the classroom: Tommy tunes in.


Mast cells in the upper respiratory tract.


The intrastitial blood supply of the lateral geniculate body.


Audio-visual aids in childbirth education.


Thyroxine metabolism in obese adolescent males.


Immunoglobulin concentrations in newborn infants with congenital cytomegalic inclusion disease.


The value of special angiographic techniques in the management of patients with abdominal neoplasms.


Comparison of cyclophosphamide and 5-fluorouracil in the treatment of patients with metastatic breast cancer.


Endemic goiter in the Ueles: a study of thyroxine-binding proteins.


Induction of lysogenic culture of Micrococcus lysodeikticus by antibiotics selectively affecting DNA synthesis.


Physiologic combinations of synthetic thyroid hormones in myxedema.


The effects of copper salts on experimental porphyria.


2-(2-Dimethylaminoethoxy)-3-(4-methoxybenzyl)-4H-pyrido[1,2-a]pyrimidin-4-one HC1 (CL-1182C), a potent histamine releaser.


Imidazomidazoles. II. Structural features affecting formation of hydantoins or tetrahydroimidazo[4,5-d]imidazole-2,5-diones.


Studies on chemotaxis. II. The significance of normal sera for chemotaxis induced by various agents.


The reaction of rheumatoid factor with bovine IgG fragments obtained by papain digestion and by reduction.


Pyroglobulinaemia: some characteristics of a heat labile protein.


Stevens-Johnson syndrome associated with administration of a combination of isonicotinic acid hydrazide and thiacetazone.


Argyrophilic fibres in repair of chronically inflamed gingival connective tissue.


The use of zinctetracycline as a fluorescent stain for the serum lipoproteins in immunoelectrophoresis.


Incidence of juvenile thyrotoxicosis in Madras, 1959-1964.


Differential spore and lipid staining at room temperature by use of fluorescent dye.


Synthesis of reovirus ribonucleic acid in L cells. Kudo, Hajime (The Wistar Institute of Anatomy and Biology, Philadelphia, Pa.), and A. F. Graham. Synthesis of reovirus ribonucleic acid in L cells. J. Bacteriol. 90:936-945. 1965.-There is no inhibition of protein or deoxyribonucleic acid (DNA) synthesis in L cells infected with reovirus until the time that new virus starts to form about 8 hr after infection. At this time, both protein synthesis and DNA synthesis commence to be inhibited. Neither the synthesis of ribosomal ribonucleic acid (RNA) nor that of the rapidly labeled RNA of the cell nucleus is inhibited before 10 hr after infection. Actinomycin at a concentration of 0.5 mug/ml does not inhibit the formation of reovirus, although higher concentrations of the antibiotic do so. Pulse-labeling experiments with uridine-C(14) carried out in the presence of 0.5 mug/ml of actinomycin show that, at 6 to 8 hr after infection, two species of virus-specific RNA begin to form and increase in quantity as time goes on. One species is sensitive to ribonuclease action and the other is very resistant. The latter RNA is probably double-stranded viral progeny RNA, and it constitutes approximately 40% of the RNA formed up to 16 hr after infection. The function of the ribonuclease-sensitive RNA is not yet known. Synthesis of both species of RNA is inhibited by 5 mug/ml of actinomycin added at early times after infection. Added 6 to 8 hr after infection, when virus-specific RNA has already commenced to form, 5 mug/ml of actinomycin no longer inhibit the formation of either species of RNA.


Reconstruction of the auricle in large defects after mechanical injury.


Some metabolic aspects of tolerance to bacterial endotoxin. Berry, L. Joe (Bryn Mawr College, Bryn Mawr, Pa.), and Dorothy S. Smythe. Some metabolic aspects of tolerance to bacterial endotoxin. J. Bacteriol. 90:970-977. 1965.-The tolerance to bacterial endotoxins which is produced in mice given a series of daily injections of heat-killed Salmonella typhimurium failed to occur when actinomycin D was administered with the heat-killed cells. Neither ethionine nor 2-thiouracil, when given with endotoxin, altered the development of tolerance. An injection of endotoxin, actinomycin D, or ethionine lowered the activity of the liver enzyme tryptophan pyrrolase more significantly at either 4 or 17 hr postinjection in normal mice than in tolerant mice. Similarly, an injection of either saccharated iron oxide or Thorotrast lowered liver tryptophan pyrrolase activity more extensively in normal than in tolerant animals. Activation of the reticuloendothelial system (RES) of tolerant mice, as determined by an accelerated rate of carbon clearance from the blood, was observed, but this was prevented by the appropriate dose of actinomycin D. Similar results were obtained when saccharated iron oxide, rather than endotoxin, was used to activate the RES, but these animals were not resistant to endotoxin and their tryptophan pyrrolase was normally diminished after an injection of endotoxin. Thus, RES activation may occur without tolerance developing. A more nearly normal level of enzyme activity appears to be characteristic of the tolerant state.


Changes in blood clotting and fibrinolysis in burnt dogs and the effect of dextran.


Surgical treatment of 3rd and 4th degree burns.


The problem of protruding premaxilla in bilateral total clefts.


Fissura colli medialis.

Fissura colli medialis.


Klippel-Feil syndrome and cleft palate.

Klippel-Feil syndrome and cleft palate.


Oxygen saturation of skin graft and recipient zone for improving the take.


The disorder in iron metabolism developing in burns disease.


The use of audiovisual techniques to expand lipreading and auditory experiences of young deaf children.


Sights and sounds and auditory training program for young deaf children.


Teaching card punch operators through the use of filmed lessons.


The use of new educational media and techniques in a school for the deaf.


Some problems in audiovisual education for the deaf.


The Responsive Environments Project and the deaf.


Experiences with percutaneous stereotaxic cryocordotomy.


Physiological aspects of thyroglobulin immunity. 3. Studies of localization of antibodies in vascular tissue and abnormal plasma thyroxine binding in the guinea pig.


Effects of meperidine hydrochloride and morphine sulfate on the lung capacity of intact dogs.


Simple method for staining and preserving epoxy resin-embedded animal tissue sections for light microscopy.


Passage of I-131-albumin and I-125-gamma globulin into the small intestine of calves.


pH stability and activity curves of pepsin with special reference to their clinical importance.


Acridine orange staining of purified rat virus strain X14.


Ribonucleates and the Gram stain.

Ribonucleates and the Gram stain.


Immunofluorescence studies in a case of Goodpasture's syndrome.


Rheumatic symptoms during tuberculosis therapy. A manifestation of isoniazid toxicity?


Speech audiometry: taped vs live voice.

Speech audiometry: taped vs live voice.


Gastric hyalinization without irradiation.


Changes in heart volume and blood volume during recovery from congestive cardiac failure.


Thematic analysis of dreams: inter-scorer reliabilities.


Differences in amino acid composition of rabbit gamma-G-immunoglobulin light polypeptide chains controlled by allelic genes.


Management of benign prostatic hypertrophy.


Serum protein bound iodine in pulmonary tuberculosis.


Cell differentiation in Chlorella.

Cell differentiation in Chlorella.


Effects of clomiphene on oestradiol alterations in thyroxine and cortisol transport in man.


Preferential recombination of antibody chains to form effective binding sites. The recovery of hapten-binding activity by a mixture of H and L polypeptide chains of the whole gammaG-immunoglobulin fraction from rabbit anti-p-azobenzenearsonate (Rp) serum is almost as great as that by a mixture of H and L chains from specifically purified Rp antibody. Random combination among the H and L chains from the anti-Rp antibodies and the normal gammaG-immunoglobulin present would result in little recovery of hapten-binding activity. This suggests a preferential recombination of H and L chains from antibody. Mixtures of H or L chains from anti-p-azobenzoate (Xp) antibody and the complementary chains from antibody-depleted gammaG-immunoglobulin show little hapten-binding. When anti-Xp antibody H chains are added to mixtures of one equivalent of anti-Xp L chain and increasing amounts of non-specific L chain, the hapten-binding by the mixtures decreases, but not as much as if the H chains combined with the L chains randomly. Hapten was not present during these recombination procedures. These data indicate that in the cases of anti-Xp and of anti-Rp antibodies, there is a selective combination between those H and L chains which give effective hapten binding regions.


Distribution among the gamma-globulin molecules of different genetically determined antigenic specificities in the Gm system. Isolated myeloma proteins and anti-Rh antibodies were utilized for determination of the distribution among the gamma-globulin molecules of various Gm(b) and Gm(f) determinants. All of these genetic factors are as a rule inherited together in Caucasians, but not in other races. The Gm(b) determinants, except (b(2)), were found together in the same Caucasian myeloma globulins of the Vi H chain group, which never carried Gm(f) or (b(2)). The Gm(f) and (b(2)) determinants were found together in other myeloma globulins, of the We group. Anti-Rh antibody molecules appeared to be similar to myeloma molecules in these respects. A few myeloma proteins and anti-Rh antibodies were encountered which reacted with some but not other anti-Gm(b) or anti-Gm(f) reagents; the only available Vi type myeloma protein from a Negro, specifically lacked the Gm(b(3)) factor. The observations might be explained by the following hypothesis: In Caucasians with the common Gm(f) Gm(b) gene complex the Gm(b) antigenic determinants, except (b(2)), co-occur in certain molecules, which contain a polypeptide chain determined by the Gm(b) gene; the Gm(f) and (b(2)) determinants co-occur in other molecules, which contain a polypeptide chain determined by the Gm(f) gene. Individuals that lack some Gm(b) or Gm(f) determinants most likely have a gene partly different from Gm(b) or Gm(f). The value of studies with myeloma proteins from individuals of different racial groups was apparent from this study. One myeloma protein from a Chinese was unique in that it was both Gm(a+) and Gm(f+).


On the participance of RNA in reflectoral activity of white mice.


The immune mechanisms in the natural history of gastric atrophy.


Studies on acute stimulatory effect of cold on thyroid activity and its mechanism in the guinea pig.


Intestinal metaplasia with argentaffin cells in cervical adenocarcinoma.


Inhibition of mitochondrial succinate oxidation by alkyl hydroxy naphthoquinones.


A study of the thyroglobulin, thyroidal protease and iodoproteins in two congenital goitrous cretins.


Gas chromatographic analysis of polynuclear aromatic hydrocarbons with packed columns. Application to air pollution studies.


Immunohistopathologic study of localized plasma proteins and fixation of guinea pig complement in renal lesions of diabetic glomerulosclerosis.


Serum proteins and teratogenesis.

Serum proteins and teratogenesis.


The dose-dependent effect of heparin and SP-54 on Triton-induced lipemia in rats.


Communication with the local community.

Communication with the local community.


Clinical applications of quantitative radiocardiography. II. Results in patients with hypertensive and coronary heart disease without clinical signs of cardiac decompensation.


The triiodothyronine suppression test in hyperthyroid patients on antithyroid medication.


The use of osbil for routine cholecystography.


Palliative treatment of metastatic tumors of the soft somatic tissues with irradiation and chemotherapy.


The contrasting immunosuppresant effects of acriflavine and dietary restriction.


Studies on the catabolism of gamma- G subunits and chains.


Anaphylatoxin formation by purified human C'1 esterase.


Some influences of antigen concentration and nonreacting additives on mobility and diffusion in immunoelectrophoresis.


The Gomori aldehyde fuchsin stain in the study of sulphation. A histochemical study in human lung tissue.


Search for osteomalacia in 1228 patients after gastrectomy and other operations on the stomach.


Osteomalacia after gastrectomy. A response to very small doses of vitamin D.


Inhibition of catecholamine synthesis in man with alpha-methyl-tyrosine, an inhibitor of tyrosine hydroxylase.


Iron absorption in cystic fibrosis.

Iron absorption in cystic fibrosis.


Laryngectomy in the management of severe dysphagia in non-malignant conditions.


Absorption and excretion of fat, nitrogen, and minerals from "filled" milks by babies one week old.


Infant feeding with SMA. Further observations.


Familial Guillain-Barŕe syndrome.

Familial Guillain-Barŕe syndrome.


Platelet stickiness in multiple sclerosis.


Platelet adhesiveness in multiple sclerosis.


Immunological aspects of carcinomatous neuropathy.


Drug addiction.

Drug addiction.


Psychiatry in the tropics.

Psychiatry in the tropics.


Maternal age at birth and susceptibility to lung cancer.


Potassium chloride and intestinal ulceration.


Thiazides and cerebral ischaemia.

Thiazides and cerebral ischaemia.


Dexamphetamine sulphate in mice.

Dexamphetamine sulphate in mice.


Methylene-blue in alcohol-induced hypoglycaemia.


Diabetes in Malta. A pilot survey.

Diabetes in Malta. A pilot survey.


Intrinsic-factor secretion in stomach diseases.


Dexamethasone and dexamethasone-aspirin in the treatment of chronic rheumatoid arthritis. A controlled trial.


Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin tests.


Delayed closure of the pulmonary valve in obliterative pulmonary hypertension.


Plasma-insulin levels in "pancreatic diabetes".


Thromboembolic phenomena after ovarian stimulation with human gonadotrophins.


Spinal subdural abscess.

Spinal subdural abscess.


Detection of venous thrombosis in the legs.


Plasma-renin concentration in hypertensive disease of pregnancy.


Origin of fibrosis after peripheral nerve division.


Incidence of infective hepatitis followed by Down's syndrome nine months later.


New trephine for subungual haematoma.

New trephine for subungual haematoma.


Simple stimulator for use in stereotactic surgery.


The lymphoblastic lymphoma of childhood.


Respirator treatment in hyaline-membrane disease.


Birth control. The restrictions of the western approach.


Some observations on malaria in children returning from holidays in the tropics.


Potassium chloride and intestinal ulceration.


Inhibition of bishydroxycoumarin activity by phenobarbital.


The cell types found in the pharynx of Polystomoides malayi Rohde.


The staining of combined thick and thin blood films on the same slide with modified Field's rapid stain.


The immunoglobulins. II. The hypergammaglobulinemias.


Ventilation for engine exhaust gases.

Ventilation for engine exhaust gases.


Neobehaviorism and Piaget's views on thought and symbolic functioning.


Restoration by albumin of oxidative phosphorylation and related reactions.


Optical rotatory dispersion of nonhelical proteins.


Optical rotatory dispersion studies of rabbit gamma-G-immunoglobulin and its papain fragments.


Antibodies against cytochromes c from vertebrates.


Inoperable cancer of the esophagus: use of the Mousseau-Barbin tube in palliative surgery.


How to use audiovisual communications.

How to use audiovisual communications.


An evaluation of adrenalectomy and androgen in disseminated mammary carcinoma.


Low doses of progestogen as an approach to fertility control.


Educational functions of the medical consultant in vocational rehabilitation. I. motivations and methods.


Phase contrast microscopy on ultrathin sections in the morphological study of the exocrine pancreas.


Experimental production of germinal follicles in the thymus. Relationship of Hassall's corpuscles to germinal follicle formation.


Antibodies to denatured autologous antigens.


The antigenicity of altered autologous proteins, a mechanism of autoimmune reactions.


The antibody response in rabbits to previously tolerated antigens.


Macroglobulin rheumatoid factors directed toward buried antigenic sites of human gamma-globulins.


Studies of hyperimmunization.

Studies of hyperimmunization.


Heterogeneity among the immunoglobulins with antithyroglobulin activity in clinical and experimental thyroiditis.


Experimental autoimmune renal disease in rats.


The possible role of autoantibodies in chronic human and experimental glomerulonephritis.


Autoimmunity: theoretical aspects.

Autoimmunity: theoretical aspects.


Teaching and audio-visual aids.

Teaching and audio-visual aids.


The determination of the rate of deiodination of thyroxine in human subjects.


Studies of parietal cell antibody in pernicious anemia.


Myelopathy in hepatic disease and portosystemic venous anastomosis.


Chorea gravidarum.

Chorea gravidarum.


Normal insulin response to glucose.

Normal insulin response to glucose.


Adverse effect of maternal hyperventilation on the foetus.


The prophylactic use of antacids in the prevention of the acid-pulmonary-aspiration syndrome (Mendelson's syndrome).


Serum lipids and lipoproteins during long-term administration of an oral contraceptive.


Isolation of rubella virus in a case of neonatal giant-cell hepatitis.


Effectiveness of chrysomallin under experimental conditions.


Inhibition by acetohydroxamic acid of human mucosal and faecal urease-specific activity.


Electrical treatment of anal incontinence.


Blood-uric-acid levels in familial hypercholesterolaemia.


Skin donor selection by leucocyte typing.


W.H.O. and tuberculosis.

W.H.O. and tuberculosis.


The Balkan nephropathy.

The Balkan nephropathy.


Absorption of corticosteroids through the skin.


Sir William Leishman: 1866-1926.

Sir William Leishman: 1866-1926.


Detection of industrial lead poisoning.

Detection of industrial lead poisoning.


Argininosuccinic acid in monilethrix.

Argininosuccinic acid in monilethrix.


Renal rete mirabile.

Renal rete mirabile.


XX-XY lymphoid chimaerism in congenital immunological deficiency syndrome with thymic alymphoplasia.


Plasma-cortisol response to lysine-vasopressin. Comparison with other tests of human pituitary-adrenocortical function.


Perinatal varicella.

Perinatal varicella.


Response to drugs of isolated human colonic muscle from a case of Hirschsprung's disease.


Vagitus Uterinus. Crying in utero.

Vagitus Uterinus. Crying in utero.


Schizophrenia-melanosis: cause or side-effect?


The pink spot.

The pink spot.


The foetal thymus.

The foetal thymus.


Malignant melanoma of the skin.

Malignant melanoma of the skin.


Bladder tumours in industry.

Bladder tumours in industry.


Mercury embolism after blood-sampling.

Mercury embolism after blood-sampling.


Towards the development of electronic data-processing systems for medical records.


Pyridine nucleotides in cancer.

Pyridine nucleotides in cancer.


Methylcobalamin in pernicious anaemia.

Methylcobalamin in pernicious anaemia.


Acid mucopolysaccharide in heart-valves.


Myalgia and an oral contraceptive.

Myalgia and an oral contraceptive.


Histamine-infusion test.

Histamine-infusion test.


A diaphragm bioassay for the measurement of total 'insulin-like activity' and of 'antigenic insulin' in serum.


Albumin and gamma-globulin tracer studies in protein depletion states.


Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation.


Pharmaco-economic approach to minimize cancellation of appointments.


Antibodies against gamma-globulin after repeated blood transfusions in man.


The displacement of modesty from pubis to face.


Endemic goitre in Thailand. A study contrasting these iodine-deficient goitres with sporadic non-toxic goitres seen in London.


Production of black tongue in dogs by feeding diets containing jowar (Sorghum vulgare).


Quadriplegia in a patient on anticoagulant therapy.


Studies on the macroglobulins of human serum. I. Polyclonal immunoglobulin class M (IgM) increase in infectious mononucleosis.


High levels of blood histamine and peptic ulcer.


Emissions from carbureted and timed port fuel injected engines.


Effect of thyrocalcitonin in man.

Effect of thyrocalcitonin in man.


Radiochromium in the selection of patients with haemolytic anaemia for splenectomy.


A successful quintuplet pregnancy following treatment with human pituitary gonadotrophin.


The effect of vagotomy on gastrin-stimulated gastric-acid secretion in man.


The changing face of myeloma.

The changing face of myeloma.


Renal function and phosphorus excretion after human renal homotransplantation.


Outpatient treatment of psoriasis. A double-blind trial of ointments.


Intestinal perforation due to swallowed fish or meat bone.


Effects of diazoxide on insulin secretion in vitro.


Blood-viscosity in diabetic patients.

Blood-viscosity in diabetic patients.


Fluorosis as a cause of finger clubbing.


Curtailing the curriculum.

Curtailing the curriculum.


Circumstances alter sweeteners.

Circumstances alter sweeteners.


Circumcision and cervical cancer.

Circumcision and cervical cancer.


A new thyroid hormone.

A new thyroid hormone.


Perinatal mortality in Newcastle upon Tyne 1960-62.


Medical education and the health services. A critical review of priorities in a developing country.


The increasing work-load in general practice.


Precision space-filling atomic models.

Precision space-filling atomic models.


Indications for surgery in glioblastomas.


Congenital familial sensory neuropathy with anhidrosis.


Myasthenia gravis. Immunological relationship between striated muscle and thymus.


Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma-sugar, and plasma-insulin during oral carbohydrate tolerance tests.


Effect of phytohaemagglutinin on marrow regeneration in rodents.


Combined mediastinal and retroperitoneal fibrosis.


Transluminal arterial recanalisation.

Transluminal arterial recanalisation.


The radiological assessment of gastric acid secretion.


Bacteraemia after urological instrumentation.


Cultivation of viruses from a high proportion of patients with colds.


Method for testing the bacteriological efficiency of surgical masks in the operating-theatre.


The interaction of drugs.

The interaction of drugs.


Thyroid surgery and hypoparathyroidism.

Thyroid surgery and hypoparathyroidism.


A roomful of mercury.

A roomful of mercury.


"B" virus: herpes virus simiae.

"B" virus: herpes virus simiae.


Therapeutic abortion.

Therapeutic abortion.


Another chance for thalidomide?

Another chance for thalidomide?


Propranolol in parkinsonian tremor.

Propranolol in parkinsonian tremor.


Lysosomes and tissue breakdown.

Lysosomes and tissue breakdown.


Hormone therapy in pulmonary tuberculosis.


Radiation exposure in parents of mongols.


Diverticulitis.

Diverticulitis.


Methyldopa and haemolytic anaemia.

Methyldopa and haemolytic anaemia.


Teratogenic effect of dimethyl sulphoxide.


Another chance for thalidomide.

Another chance for thalidomide.


Gastrointestinal function in anticonvulsant megaloblastic anaemia.


The effect of surgical operation on thyroid function.


Platelet aggregation and release of ADP, serotonin and histamine associated with phagocytosis of antigen-antibody complexes.


Effect of some ototoxic drugs upon the pattern and innervation of cochlear sensory cells in the guinea pig.


A study on histogenesis of parotid mixed tumors with PAM and alcian bluepas staining.


Generalized arterial and arteriolar vasculitis with marked plasmacytosis and hypergammaglobulinemia: report of an autopsy case.


Pathology of amyloidosis. Polarization microscopic investigation of amyloidosis in Japan.


Erythropoietic polyploidy II. Erythropoietic polyploidy in relation to thyroid function and treatment with thyrostatic compounds.


Gammaglobulin factors (Gm and Inv) in New Guinea: anthropological significance. Analysis of the hereditary Gm and Inv gamma-globulin factors of 1669 New Guineans from the Morobe and Eastern Highlands districts and Bougainville Island demonstrates thatthe frequencies of the three Gm alleles present (Gm(a), GM(ab), and Gm(ax)) are similar in general to those in Mongoloids and in particular to those in Southeast Asians and Micronesians. The New Guinea frequencies are distinct from those in other populations, including Australian aborigines. Highly significant differences in frequencies of Gm and Inv alleles occur between Melanesian-and non-Austronesian-speaking New Guineans.


Electron microscopy: sodium localization in normal and ouabain-treated transporting cells. When rabbit corneas are fixed in an osmic acid fixativeto which potassium pyroantimonate has been added, an electron-opaque precipitate of sodiium pyroantimonate is localized along the cellular side of the lateral plasmla membrane of the endothelial cells. This heavy precipitate represents areas of high Na(+) concentration and may represent the site of a saturated, high-affinity Na(+) carrier. Significantly heavier precipitate occurs at the same site when ouabain is injected into the aqueous humor prior to fixation of the cornea.


Immunoglobulin A production in ataxia telangiectasia. Serum from five patients with ataxia telangiectasia contained no detectable immunoglobulin A (IgA). However, there was evidence (by immunofluorescence) of IgA in the bone marrow of the three patients so examined, suggesting that the defect in IgA production was not complete. IgA was in the saliva of all five patients and in the parotid gland of the one patient studied. This is further evidence of IgAsynthesis by the salivary glands.


Influence of antirheumatic agents on the release of histamine from rat peritoneal mast cells after an antigen-antibody reaction.


Idiopathic autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura associated with diffuse hypergammaglobulinemia, amyloidosis, hypoalbuminemia and plasmacytosis.


Unusual immunologic alterations in sarcoidosis during repeated Kveim testing.


Isolation of a new urine metabolite excreted in generalized congenital analgesia.


LDH isoenzymes after electrophoretic separation on agar gels prepared from different kinds of agar.


The electrophoretic nature of human amylase and the effect of protein on the starch-iodine reaction.


Passive sensitization of skin and lung by guinea-pig immunoglobulins.


Immunoglobulins and antibody formation in mice during the graft versus host reaction.


GM and INV factors in subclasses of human IgG. Human G myeloma (7S gamma(2)-myeloma) proteins were investigated for relationships between Gm and Inv genetic factors and the different antigenic types of heavy polypeptide chains (gamma-chains) and light polypeptide chains. Myeloma proteins were isolated from the sera of 1 Chinese, 60 white and 28 Negro individuals. These 89 proteins were tested for eight Gm factors [Gm(a), Gm(x), Gm(b(2)), Gm(f), Gm(b(1)), Gm(b(3)), Gm(b(4)), and Gm(c)], and two Inv factors [Inv(l) and Inv(b)]. Results of the tests were correlated with the four gamma-chain subclasses (gamma(2a), gamma(2b), gamma(2c) and gamma(2d)) and the two types of light polypeptide chains, kappa-chains (type K or I) and lambda-chains (type L or II) found in human IgG molecules. 1. Gm factors were limited to myeloma proteins with heavy polypeptide chains of the gamma(2b)- and gamma(2c)-subclasses. No Gm factors were detected on gamma(2a)- and gamma(2d)-myeloma proteins or on a "heavy-chain" disease protein of subclass gamma(2d). 2. gamma(2b)-Proteins were positive for at least one Gm factor and were either Gm(a+), Gm(a + x+), or Gm(b(2)+ f+). 3. gamma(2c)-Myeloma proteins, and one gamma(2c)-"heavy-chain" disease protein, were positive for at least one Gm factor and contained various combinations of factors Gm(b(1)), (b(2)), (b(4)), and (c). Myeloma proteins from 3 Negroes were included in this group. 4. Inv factors (l) and (b) were limited to myeloma proteins with kappa-light polypeptide chains. These Inv factors were not detected on proteins with lambda-light polypeptide chains. 5. Most (70 per cent) of the gamma(2b)- and gamma(2c)-proteins with kappa-chains were Inv(l+) or Inv(b+). None of the gamma(2a)- or gamma(2d)-proteins with kappa-chains, however, contained these Inv factors.


Role of the thymus in tolerance. I. Tolerance to bovine gamma globulin in thymectomized, irradiated rats grafted with thymus from tolerant donors. Rats thymectomized and irradiated as adults were restored to immunologic reactivity by grafts of normal adult rat thymus and bone marrow. Reactivity of the delayed (cellular) type and formation of mercaptoethanol-sensitive (MES) and mercaptoethanol-resistant (MER) antibody returned within 3 weeks, while Arthus reactivity remained subnormal till 9 weeks after irradiation and grafting. When the thymus donor was tolerant to BGG, the recipient showed specific non-reactivity to this antigen 3 weeks and, to a much lesser extent, 6 weeks after grafting. This non-reactivity affected delayed responses and MER antibody. No effect was noted on Arthus reactivity and a slight effect on MES antibody. Controls showed that the non-reactivity was not due to transfer of free antigen at the time of grafting. It was concluded that different source organs are responsible for different immune functions and that specific immunologic tolerance may be induced within such an organ as the thymus.


Abdominal distress and ascites of seven years' duration. Résumé of case.


The immunological development of the human fetus. The immunogenesis of the human fetus has been investigated by means of the formation of immunoglobulins in vitro, immunofluorescence, morphological studies, and analysis of the immunoglobulins in the serum. Twenty fetuses which were born alive but died soon after delivery, were studied; their ages ranged from 13 to 31 weeks. The results of the spleen cultures demonstrated the synthesis of IgG and IgM, which starts at about the twentieth week of gestation. In the serum, IgM could be detected at about the same period. The immunofluorescent staining of the spleen tissue showed that medium sized and large lymphoid cells as well as plasma cells, even with Russell bodies, were positive for either IgG or IgM. The peripheral blood was also found to contain a small number of medium sized IgG and IgM-positive cells. Both the spleen and the peripheral blood showed a considerable number of fluorescent small lymphocytes which exclusively contained IgM. The relatively high ratio of IgM to IgG production prenatally as compared to the postnatal situation, agrees with a predominantly primary antibody response in fetal life. In general, the fetal thymus did not synthesize immunoglobulins. No indications for the synthesis of IgA and IgD during fetal life were found.


Demonstration of the functional anatomy of the canine gastric antrum. II. Operative technics not requiring gastrotomy.


Fluorescence depolarization. A study of the influence of varying excitation wavelength and solution concentration.


Left heart bypass in normo- and hypothermia. An experimental study on dogs and a clinical report.


Release of histamine from stomach by vagus-stimulating drugs: association with gastric acid secretion.


Acute poststreptococcal glomerulonephritis: immune deposit disease.


The release of histamine and 5-hydroxytryptamine from perfused hindquarters of dextranresistant rats.


Comparison of the effects of various agents on histamine release and mast cells in the rat, in vivo and in vitro.


Hypothyroidism following 131-I treatment for hyperthyroidism.


Provenience of the death symbolism in Van Gogh's cornscapes.


Relationship between the in vitro uptake of 131-I-triiodothyronine by erythrocytes and its binding by serum proteins in thyroid disease.


Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues. The cellular localization of allotypes in rabbit lymphoid tissues has been studied by immunofluorescence. In heterozygous animals the double staining for two allotypes controlled by allelic genes (A1 and A2; A4 and A5; A4 and A6) has shown the existence of two populations of plasma cells, one containing one allotype and the other the alternative one. The localization in different cells of immunoglobulins marked by allelic allotypic specificities has been confirmed by microspectrography of single cells. An exception to this rule was given by the presence in the germinal centers of lymphoid follicles of apparently uniform mixtures of products of the two allelic genes. Double staining for two allotypes controlled by genes at different loci showed, instead, the presence of many cells containing both allotypes; the number of these cells was highest in doubly homozygotes, in the other it was consistent with random association of non-allelic specificities. In addition double staining for one allotype and gamma G globulins in the lymphoid tissues of rabbits homozygous at the a or at the b locus, has shown the presence of cells containing immunoglobulins that lack one allotype.


Clinical histological and electron microscope study of a case of Whipple's disease; before and after treatment with aureomycin. A contribution to the understanding of this condition's nature.


A study of the ability of English speakers to guess the meanings of nonantonym foreign words.


Studies on rabbit lymphocytes in vitro. IV. Blast transformation of the lymphocytes from newborn rabbits induced by antiallotype serum to a paternal IgG allotype not present in the serum of the lymphocyte donors. Lymphocytes from the peripheral blood of newborn rabbits heterozygous for IgG allotypes As4 and As5, or As5 and As6, obtained at an age when only the maternal allotypic determinants are detectable in the serum, may be stimulated in vitro to transform into "blast" cells with antiallotype sera directed against the determinants contolled both by the maternal and by the paternal chromosomes. This result rules out the possibility that allotypic specificity is conferred upon lymphocytes by environmental IgG and suggests that the lymphocytes of newborn rabbits have the potential to synthesize IgG determinants either in the form of intact IgG molecules or constituent polypeptide chains.


Role of histamine in mediation of hormone action.


Videotaped autobiographical interviews. An adjunct for medical education.


The occurrence of cytomegalovirus infections in childhood leukemia.


Changes in antibody titers and serum protein fractions during the course of prolonged infections with vivax or with falciparum malaria.


Toxicity of alloys of ferrochromium. II. Interations of chromium 3 with proteins of human serum.


The identification of some specific meanings in infant vocalization.


Effect of age on reticuloendothelial function in man.


Ileal urinary diversion in conjunction with renal homotransplantation.


A psychophysiological investigation of hyperthyroidism.


Last-resort treatment of status asthmaticus.


Aminocaproic acid in the control of haemorrhage after prostatectomy. A controlled trial.


Aminocaproic acid in the control of haemorrhage after prostatectomy. Safety of aminocaproic acid--a controlled trial.


Viscosity of blood in healthy young women. Effect of menstrual cycle.


Double and triple pulse pacemaking in treatment of ventricular tachycardia.


Thrombotic microangiopathy. Recovery of a case after heparin and magnesium therapy.


Haemosiderosis associated with xanthine oxidase inhibition.


Hypokalaemia during extracorporeal circulation.


Tetanus: a dilemma prolonged.

Tetanus: a dilemma prolonged.


Anticoagulants and cerebral infarction.

Anticoagulants and cerebral infarction.


London's skid row.

London's skid row.


The cytopipette in the diagnosis of early cervical carcinoma.


Domiciliary testing of cervical smears by home nurses.


Education or research?

Education or research?


Methyldopa and haemolytic anaemia.

Methyldopa and haemolytic anaemia.


The shocked head injury.

The shocked head injury.


Continuous determination of enzyme activity during heat inactivation.


Haemorrhage in the newborn of epileptic mothers.


Viral hepatitis in G.-6-P.D. deficiency.


Trisomy G without Down's syndrome.

Trisomy G without Down's syndrome.


Organ antibodies in Sjögren's syndrome.

Organ antibodies in Sjögren's syndrome.


Echoencephalography in the differential diagnosis of cerebral haemorrhage and infarction.


Milk-and-cheese diet in portal-systemic encephalopathy.


Importance of disaccharide intolerance in the treatment of coeliac disease.


Penicillamine and pyridoxine requirements in man.


Acute anuria in a haemophiliac; due to transfusion of incompatible plasma.


Mucin secretion and striated muscle in the human thymus.


Possible induction of antinuclear antibodies by isoniazid.


A cuffed tracheostomy tube.

A cuffed tracheostomy tube.


Detection of industrial lead poisoning.

Detection of industrial lead poisoning.


Alkaline phosphatase activity of rhizobium trifolii mutants.


Effect of lysogenization on variability of phage type in Rizobium meliloti.


Histochemical and immunological study of Candida albicans chlamydospores. I. Histochemical properties of C. albicans chlamydospores (Double staining method of chlamydospores).


A histochemical and immunological study of Candida albicans chlamydospores. II. Immunofluorescent study of the antigenic properties of C. albicans chlamydospores.


Antigenic structure of Salmonella typhimurium. I. Immunochemical properties of extracts obtained by various methods.


Antigenic structure of Salmonella typhimurium . II. A comparison of phage types.


Studies on Rhizobium trifolii antigens II.


Preparation and chemical analysis of mucopeptide fractions of Bacillus megaterium cell walls.


Effect of antibiotics on incorporation of 14C-glutamic acid into cell walls of Bacillus megaterium.


Effect of certain cations on the growth of Lactobacillus lactis and Lactobacillus delbrueckii. 3. The influence of Ca++, Fe++, Cu++ ions.


Investigations on the variability of pathogenicity of Newcastle disease virus. V. Influence of hypovitaminosis B2 or B12.


Effect of tingitanine (lathyrine), diaminobutyric acid and homoserine on Rhizobium.


Fungi associated with roots of tobacco resistant and susceptible to black root-rot.


Microflora of a river polluted with cellulose and paper mill waste waters.


Studies on citric acid synthesis. 3. The synthesis of vitamins B by strains of Aspergillus niger of different acid production activity.


Dose of anti-D gamma-globulin in prevention of Rh-haemolytic disease of the newborn.


Albumen-gel as a supporting medium in zone electrophoresis.


Cardiac lesions in rabbits injected with autologous gamma-globulin.


Enzyme stimulation and inhibition in the metabolism of drugs. Studies in recent years have disclosed two types of drug interaction which may be important in drug therapy:(1) Administration of one drug can speed up the metabolism of another drug. Animal experiments show that this results from the ability of drugs to induce the synthesis of drug-metabolizing enzymes in liver microsomes. This effect has considerable importance in pharmacologic and toxicologic studies carried out in animals, and recent work indicates that it may explain altered therapeutic responses observed in some patients when they receive several drugs at the same time. Substances present in the environment, such as the insecticides chlordane and DDT, have been shown in animals to stimulate drug-metabolizing enzymes in liver, but the significance of this observation for man is not known. Drugs which stimulate drug metabolism also enhance the hydroxylation of testosterone, estradiol, progesterone and cortisol by enzymes in liver microsomes. Further research is required to establish the physiological importance of this interaction of drugs in steroid metabolism.(2) One drug may inhibit the metabolism of another drug and thus intensify and prolong its pharmacologic action. Although this effect is well documented in animals, recent reports suggest that this may also be important in man. For instance, the action of coumarin anticoagulants can be potentiated by administration of certain drugs which inhibit their metabolism. Monoamine oxidase inhibitors block the metabolism of certain sympathomimetic amines and this can lead to serious side-effects. Thus, hypertensive crises have been observed in patients receiving monoamine oxidase inhibitors who have eaten cheese with a high tyramine content.


Protein-bound and inorganic iodine in serum of younger and older euthyroid subjects and changes following the administration of triiodothyronine.


Nitrogen dioxide fixation in bacterial chromatin studies. Eller, Charles (St. John's University, Jamaica, N.Y.), and William H. Beckert. Nitrogen dioxide fixation in bacterial chromatin studies. J. Bacteriol. 90:1710-1712. 1965.-Satisfactory chromatin staining was obtained with two Bacillus species when nitrogen dioxide was used for fixation in conjunction with either the acid Giemsa or Feulgen staining methods. An impression method was employed for the transfer of bacilli to a new environment as well as for smears. Advantages of nitrogen dioxide fixation are discussed.


Intrarenal monitoring of cardiac output in the regulation of sodium excretion.


Inhibition of gastrin secretion in the human stomach. Effect of acid in the duodenum.


Peptic ulcer in the  haemophiliac and its relation to gastrointestinal bleeding.


Clinical and biochemical aspects of cardiac resuscitation.


Immunoglobulins in viral hepatitis and active alcoholic liver-disease.


Value of dilute inocula in cultural examination of sputum.


Locating the kidney for renal biopsy.

Locating the kidney for renal biopsy.


Low-molecular-weight dextran in the treatment of peripheral arterial insufficiency.


Apparent low serum-vitamin-B12 levels associated with chlorpromazine. An artefact.


The eventful history of B. H. T.

The eventful history of B. H. T.


Another chance for thalidomide?

Another chance for thalidomide?


Transluminal T-tube drainage in pancreatobiliary surgery. A way out of difficulty.


The digital computer in the classification and diagnosis of diseases.


Crop chemicals and lung cancer.

Crop chemicals and lung cancer.


Thalidomide.

Thalidomide.


"Cri du Chat" due to a ring-B chromosome.


Subacute viral encephalitis amnesia.

Subacute viral encephalitis amnesia.


Notation for genetic factors of human immunoglobulins.


The production of gamma G-globulin by lymphocytes in chronic lymphocytic leukemia. Immunocytologic investigation of a case.


Diagnosis and treatment of lesions of the brachial plexus and adjacent structures.


Survival after resection of bronchial carcinomas. Significance of tumour cells in the blood.


Effect of serum-factors other than folate on the Lactobacillus casei assay.


Hypertension and hyperuricaemia.

Hypertension and hyperuricaemia.


Treatment of eczema vaccinatum with N-methylisatin beta-thiosemicarbazone.


The paediatrician and the termination of pregnancy.


Pudendal block--a misnomer?

Pudendal block--a misnomer?


Urine-urea-blood-urea ratios in renal failure.


Severe hypothermia with barbiturate intoxication.


Automatic sighing-device.

Automatic sighing-device.


Treatment of iron deficiency.

Treatment of iron deficiency.


Hazards of di-isocyanates.

Hazards of di-isocyanates.


Surgery of the limbic lobe.

Surgery of the limbic lobe.


Men or molecules? A tilt at molecular biology.


On learning the medical craft.

On learning the medical craft.


Dilution in general practice.

Dilution in general practice.


Does the grass grow greener...? Hospital life in America.


The angiotensin-infusion test.

The angiotensin-infusion test.


The effect of dextran and some other colloids on the suspension stability of blood from different species.


Aneurysmal protrusion of the posterior leaflet of the mitral valve. An auscultatory-electrocardiographic syndrome.


Cellular reaction to complexes formed between rheumatoid factor and aggregated human gamma globulin.


Electron microscopy of L.E. phenomena. Description of the structure of the L.E. cell and L.E. mass.


Localization of chondromucoprotein in cartilage.


Effect of antibody on the acid phosphatase reaction of tissue culture cells.


Control of DNA synthesis in mammalian cells in culture.


The demonstration of cytoplasmic basic proteins in strain L mouse fibroblasts.


NZB/NZW mice as a model of systemic lupus erythematosus.


Pig-bel: enteritis necroticans. A study in diagnosis and management.


Sequential therapy to achieve anovulatory cycles. Sequential oral contraceptive therapy was devised to inhibit ovulation by a potent estrogen alone. A progestational agent was added at the end of the course of therapy to prepare the endometrium for adequate withdrawal bleeding. The program consisted of giving 80 mug. of metranol daily for 15 days and then a combination of 80 mug. of mestranol and 2 mg. of chlormadinone acetate for five additional days. Such a regimen proved to be effective in 6070 patients carefully observed for 82,085 cycles of therapy at 25 medical centres.INCREASED CYCLE REGULARITY WAS NOTED: 98.1% of the cycles were 25 to 31 days long. In 80.1% of cycles, the withdrawal interval was two to five days in length. Duration of flow was four to six days in 85.3% of the therapeutic cycles. The amount of flow decreased as compared with pretreatment values. The incidence and severity of dysmenorrhea during sequential therapy were significantly lower than before treatment. Side effects, usually infrequent, diminished as therapy was continued; the average incidence of breakthrough bleeding was 1.9% and nausea was 2.9%. Extensive laboratory studies showed no consistent abnormalities. For oral contraception, sequential therapy has proved to be virtually 100% effective when taken as directed.


The treatment of experimental mouse hemoblastosis IV. Thearapy of leukemia L 14 AKR with drugs of demonstrated or potential cytostatic effects.


Absorption of intramuscularly administered tri-iodothyronine.


Morphological and functional characterisitics of the central and peripheral neuroglia (light microscopical observations).


Are we over-diagnosing prostatic carcinoma.


The use of negative staining in the electron microscopic examination of plant viruses in crude extracts.


Ultrastructure of Rauscher virus after phospholipase treatment.


Effects on host cell metabolism following synchronous infection with poliovirus.


Stabilization in acid of mercaptoethanol-reduced adenovirus antibody by combination with virus.


Bacteria in Whipple's disease. 3. Studies in two patients of antibodies in serum and cutaneous hypersensitivity against some bacterial antigens.


Bolivian hemorrhagic fever. A report of four cases.


Changes in morphine- and chlorpromazine-N-demethylase during the development of tolerance to chlorpromazine in mice.


Photodynamic effect of dye on frog muscle fibre using microelectrodes.


The effect of aggregated gamma-globulins on immune cytolysis: the role of complement.


Iron pigmentation of the gut of germ-free and conventionalized guinea pigs.


General-practice psychiatry. Two Canadian experiments.


The organisation of the National Health Service. Progress and problems.


Acid-base terminology.

Acid-base terminology.


Oral contraceptives and thromboembolic episodes.


Acid-base status, pH, and Pco2.

Acid-base status, pH, and Pco2.


Sulphonylurea hypothyroidism in diabetics.


Malformations in mice induced by dexamphetamine sulphate.


Immediate or later feeding for premature babies? A controlled trial.


Detection of renovascular hypertension.

Detection of renovascular hypertension.


Methisazone in prevention of variola minor among contacts.


Augmented histamine response after incomplete vagotomy.


Effect of linseed oil on platelet adhesiveness and bleeding-time in patients with coronary heart-disease.


Thiazides: A cause of necrotising vasculitis?


Successful repair of left ventricular aneurysm and ventricular septal defect after indirect injury.


Dose-dependent opposite effects of angiotensin on renal sodium excretion.


Angiotensin infusion test.

Angiotensin infusion test.


Effect of angiotensin and of frusemide on plasma aldosterone, corticosterone, cortisol and renin in man.


Pancreatic and hepatic hypersecretion in cholera.


An automatic gastric sampling pump.

An automatic gastric sampling pump.


Concentration and dilution of urine.

Concentration and dilution of urine.


Tetanus prophylaxis.

Tetanus prophylaxis.


Prophylactic  vasectomy.

Prophylactic  vasectomy.


Malignant nephrosclerosis.

Malignant nephrosclerosis.


Inhibition of endotoxin-induced platelet agglutination, histamine and serotonin release in vitro by thiol-compounds.


Another look at phonetic symbolism.

Another look at phonetic symbolism.


Stop-flow analysis of the renal excretion of tritium-labeled dihydromorphine.


Anticoagulant activity of whale heparin and its characteristics.


Fibrinogen-transmitted hepatitis; a controlled study.


The question of irradiation therapy in lung cancer.


Intestinal lipodystrophy (Whipple's disease); the immediate and prolonged effect of antibiotic therapy.


Effects of cancer on the immune globulins and immunity.


Immunologic disorders in malignant lymphomas.


A study of the structure of the lung alveolus and bronchiolar epithelium. (A histological and histochemical study using the method of membranous preparations).


Therapy of salivary gland tumors.

Therapy of salivary gland tumors.


Further experience with indomethacin in the treatment of rheumatic disorders.


A study of the specificity of the Berthelot colour reaction.


Sperm nucleus of Clibanarius longitarsis.


Properties of antibodies cytophilic for macrophages. Cytophilic activity for macrophages was shown to be a property possessed by most, if not all, of the complement binding 7S gamma(2)-population of guinea pig antibodies. Cytophilic antibodies were also demonstrated in rabbit and mouse antisera to sheep red cells. While each species antibody best sensitized homologous macrophages, cross species sensitization was also observed. The binding site for macrophages resides on the Fc fragment, therefore, on the H chains, and is destroyed by pepsin hydrolysis or reduction and alkylation. The binding reaction is reversible with a high rate of dissociation at 37 degrees C. Cytophilic activity is not complement dependent, and was shown to be that property of opsonizing antibody which provides the receptors that permit the binding of the antibody to the macrophage cell membrane in preparation for phagocytosis.


Isolation of rabbit IgA antihapten antibody and demonstration of skin-sensitizing activity in homologous skin. Multiple antibody components of rabbit antisera against p-azobenzenearsonate (R(p)) were studied with respect to their globulin nature and skin-sensitizing activity. IgA antibody was characterized by isolating two IgA-rich fractions from a specifically purified antibody preparation. Examination of these fractions showed that IgA antibodies existed in two molecular forms, one with a sedimentation constant of 7S and the other 9S. Skin-sensitizing activity was examined by a P-K type test and a PCA test with R(p)-rabbit serum albumin in homologous (rabbit) species. Only the 7S but not 9S IgA antibody sensitized rabbit skin. IgM antibody showed no activity and IgG antibody showed very low activity. In contrast, only IgG antibody was active in the P-K type test to sensitize a heterologous species (guinea pig). None of the antibodies of other classes showed sensitizing activity in heterologous skin. The 7S IgA antibody lost its sensitizing activity upon reduction and alkylation, although no change in its molecular size could be observed. The loss of sensitizing activity was not due to the destruction of antigen-binding activity since the treated 7S IgA antibody retained this activity as shown by radioimmunoelectrophoresis and by binding to the specific immunoadsorbent. The 9S IgA antibody was more resistant to these treatments than the IgM antibody and showed no indication of dissociation. The treated 9S IgA also retained antigen-binding activity. Both the P-K type and PCA reactions were considerably stronger when the interval between injections of antibody and antigen was 24 hr rather than 4 to 5 hr.


Coombs-positive hemolytic anemia caused by penicillin administration.


Hurler's syndrome. A genetic study in cell culture. Seven families affected with Hurler's syndrome have been studied using the methods of cell culture. Skin fibroblasts obtained from the skin of 7 patients with Hurler's syndrome contained metachromatic granules when stained for mucopolysaccharides with toluidine blue O and alcian blue, whereas fibroblasts from normal subjects contained no metachromatic granules. In four families skin cultures of the clinically normal parents showed fibroblasts which contained demonstrable metachromatic granules and "gargoyle" cells and were considered to be heterozygous for the abnormal gene. Fibroblast cultures from certain other members of these families showed metachromasia. These findings were also considered to indicate heterozygosity for the abnormal gene. Three families of the X-linked type of the disease were studied. Fibroblasts cultured from the father contained no metachromatic granules whereas those of the hemizygous mother contained both metachromatic granules and "gargoyle" cells. In one family the abnormal gene could be traced through unaffected individuals for three generations. The prolonged preservation of the biochemical trait in tissue culture will permit studies to be performed designed to clarify the primary action of the abnormal genes which result in Hurler's syndrome, as well as to increase the usefulness of this trait in mapping the human X chromosome.


Active-passive tetanus immunization. Choice of toxoid, dose of tetanus immune globulin and timing of injections.


IgM and IgG anti-hapten antibody: hemolytic, hemagglutinating and precipitating activity.


Comparative methods for determining biological half-life (t 1/2) of L-thyroxine in normal, throidectomized and methimazole treated female rats.


Erythropoiesis during pregnancy and lactation. I. Effect of various hormones on erythropoiesis during lactation.


Delay in treatment in carcinoma of colon and rectum.


Thrombophlebitis-inhibiting effect of percutaneously applied heparinoid ointment during intravenous infusion. Experimental study.


Requirement of energy for the cell fusion reaction of Ehrlich ascites tumor cells by HVJ.


Inhibition of RNA and interferon synthesis in Krebs-2 cells infected with vesicular stomatitis virus.


Interaction between poliovirus and immunoglobulins. I. Detection of virus antibodies by partition in aqueous polymer phase systems.


Interaction between poliovirus and immunoglobulins. II. Basic aspects of virus-antibody interaction.


Modern trends in animal health and husbandry. Recent developments in the isolation and characterization of proteins and their application to the immune globulins.


Fat embolism of bone. A roentgenographic and histological investigation, with use of intra-arterial lipiodol, in rabbits.


Presence of 'RNA immuno-carrier' in immune rabbits' serum.


Some aspects of the surgical anatomy of the hip joint.


Genetic factors and polypeptide chain subclasses of human immunoglobulin G detected in chimpanzee serums. The Gm and Inv genetic factors, characteristic antigens of human immunoglobulin G, were detected in chimpanzee serums. All animals tested were Gm(a+, x-, b(l)-, b(2)-, b(3)+, b(4)+). Polymorphism was demonstrated for factors Gm(c), Inv(l), and Inv(b). Three of the subclasses of heavy polypeptide chains and both types of light polypeptide chains that are present in human immunoglobulin G were identified in chimpanzee serums.


Association of gamma globulin with amyloid.


Antigenic behavior of the S-63 mouse leukemia virus.


The distribution of normal serum proteins within rat and human renal tubule cytoplasm as demonstrated by immunofluorescence.


Separation of macroglobulins from myeloma proteins by Sephadex G-200 gel filtration.


Plasma hematin-binding and clearance in the rhesus monkey.


Passive immunity to Ascaris suum transferred in colostrum from sows to their offspring.


Fine structural observations of the absorption of lipid particles in the small intestine of the rat.


Left, right, and identity.

Left, right, and identity.


Degradation of ribonucleic acid in mouse fibroblasts treated with actinomycin. The cellular RNA content of mouse fibroblasts incubated with actinomycin decreases at a rate of about 1 to 1.5 per cent per hour, while DNA and protein content remain unchanged. This degradation affects nuclear and cytoplasmic RNA, ribosomal and soluble RNA. The breakdown products appear quantitatively in the acid-soluble fraction of the cells and the medium. Polynucleotides synthesized a short period (120 minutes) prior to exposure to actinomycin are degraded before those synthesized 8 to 12 hours previously.


Molecular pathology. New concepts of molecular pathology in dysproteinemias.


The reaction mechanism of beta-1C-globulin (C'3) in immune hemolysis. During immune hemolysis by human complement, C'3 (beta(1C)-globulin) becomes physically attached to the erythrocyte membrane. Binding of C'3 was found to be mediated by cell-bound, activated C'2 and to have the characteristics of an enzymatic reaction. A single C'4,2a site on the cell surface effected the binding of several hundred molecules of C'3 if the latter was provided in excess. The accumulation of hemolytically inactive, physicochemically altered C'3 in the fluid phase was found to be an inherent feature of the process of C'3 binding. It is postulated that C'4,2a activates C'3 for its subsequent reaction with cell membrane receptors. Antierythrocyte antibody did not play an essential role in C'3 uptake; C'3 could be bound to erythrocyte-C'4,2a complexes which were entirely devoid of antibody. Cell-bound C'3 proved hemolytically active, the degree of hemolysis being proportional to the number of C'3 molecules per cell. Binding of a large number of C'3 molecules per cell was found to be a prerequisite for the production of the immune adherence phenomenon and for immune hemolysis.


Amodification of Noland's stain for permanent smears of protozoan flagella, cilia and spore filaments.


Cytological observations on Eimeria bovis merozoites.


Changes in serum proteins of rats infected with Toxoplasma gondii.


Failure of chlorine and sodium chloride to induce resistance in Aedes aegypti to lindane, dieldrin, and DDT.


Further electron microscopic observations on Reiter spirochetes.


Use of coomassie brilliant blue R250 for the electrophoresis of microgram quantities of parotid saliva proteins on acrylamide-gel strips.


The coupling of biologically active molecules to insoluble polymers: antibody on cellulose.


Studies of porphyrinogen and corrin biosynthesis in Clostridium tetanomorphum.


Normal serum cytotoxicity for P32-labeled smooth Enterobacteriaceae. 3. Isolation of a gammag normal antibody and characterization of other serum factors causing P32 loss. Spitznagel, John K. (University of North Carolina School of Medicine, Chapel Hill). Normal serum cytotoxicity for P(32)-labeled smooth Enterobacteriaceae. III. Isolation of a gammaG normal antibody and characterization of other serum factors causing P(32) loss. J. Bacteriol. 91:401-408. 1966.-Gram-negative bacteria lost metabolically incorporated P(32) when suspended in serum only if the serum contained heat-labile in addition to heat-stable factors. Gram-positive bacteria labeled with P(32) and included for comparison lost P(32) in heat-inactivated as well as in fresh normal serum. Further investigation of gram-negative bacteria showed that a smooth Escherichia coli (O117:H27) lost P(32) only if suspended in serum containing complement fractions C'1, C'2, C'3, and C'4 "normal" antibody and lysozyme. The normal antibody was recovered by absorption on and subsequent elution from E. coli O117:H27 cell walls. Immunoelectrophoresis showed that it was a gammaG-globulin. Its P(32)-releasing activity was destroyed by 2-mercaptoethanol. Lysozyme was found to potentiate the P(32)-releasing action of normal antibody plus complement. Evidence was obtained suggesting that beta(1C) globulin was the component absorbed to zymosan during serum absorption at 15 C. Reduction of the beta(1C) level evidently upsets an important balance that exists in normal serum among complement, antibody, and lysozyme. This balance is essential for maximal P(32) release from labeled bacteria, or possibly for a maximal antibacterial effect from normal serum. The possible relationships of bactericidal, bacteriolytic, and opsonic action of normal serum are discussed.


Heterogeneity of guinea pig antibody gamma-globulin.


Gene recombination and segregation of resistance factor R in Escherichia coli. Hashimoto, Hajime (Osaka University, Osaka, Japan), and Yukinori Hirota. Gene recombination and segregation of resistance factor R in Escherichia coli. J. Bacteriol. 91:51-62. 1966.-Independent chloramphenicol-sensitive (CM(s)) mutants of the drug-resistance factor R were isolated. Introduction of two different R factor CM(s) mutants into a single bacterium, by conjugation or transduction, gave chloramphenicol-resistant (CM(r)) colonies when such strains were plated on a medium containing chloramphenicol (Cm). These CM(r) colonies resulted from recombination between two R factors contained within the same cell. Most of the CM(r) colonies were heterogeneous, and segregation of drug-resistance markers was observed among the progeny. Segregated bacteria which still carried the recombinant R factor were stable for resistance to Cm as well as for other markers of R. All the markers of recombinant R factors were cotransducible with high coincidence and at the same frequency as wild-type R. Sensitive mutants of R which had lost all the resistance markers of the R factor were found also. A mutation of R, referred to as SMA, which was sensitive to streptomycin and sulfanilamide, was capable of reverting to resistance to both of these drugs simultaneously. The sensitive alleles for SMA, CM, and TC were shown to be recessive to the resistance alleles. Mutants of R having multisite mutations or deletions in the CM gene were isolated and used to analyze the pattern of linked segregation of unselected markers of the recombinant R factor. The drug resistance factor R was shown to have two linkage groups, CM-SMA and TC-m.


A histochemical study of the Paneth cells of the Tamandua tetradactyla (Edentata, Mammalia).


In vivo localization of anticarcinogen antibody in organs of carcinogen-treated rats.


Studies on staining and localization of acidic nuclear proteins in the walker 256 carcinosarcoma.


Arthus type inflammation with rabbit gammam antibody.