The structure of the stomatogastric neuromuscular system in Callinectes sapidus, Homarus americanus and Panulirus argus (Decapoda Crustacea).


The effect of the RL-A locus and the NLC locus on graft survival in the rabbit.


Safety and the American space program.

Safety and the American space program.


Aircraft accident toxicology: U.K. experience 1967-1972.


Letter: The physician's assistant.

Letter: The physician's assistant.


Characteristics of the hydrogen bonding interactions of substituted hydantoins with 9-ethyladenine.


Embryonal carcinoma. An unexpected cause of sudden death in a young adult.


The action of certain drugs on the immediate contractile response of isolated guinea-pig detrusor muscle to X-irradiation.


Proceedings: Evolutionary aspects of transmitter heterogeneity.


Proceedings: GABA as a transmitter in the central nervous system of vertebrates.


Oxidation of barbiturates and the glucuronidation of 1-napthol in perfused rat liver and in microsomes.


Chemical studies on individual neurons. II. Invertebrate nerve cells.


Response augmentation and blockade in cholinergic neuromuscular tissues.


Chemical correlates of neural function.

Chemical correlates of neural function.


Psychophysics of excitation and tranquilization from a steady-state perspective.


What is the functional role of central nervous serotonin?


A combined neurochemical and neurophysiological approach to identification of central nervous system transmitters.


Learning and use of knowledge.

Learning and use of knowledge.


Classifications and terminology of psychotropic drugs. A historical critical review.


Growth of stem cell concentration in diffusion chambers (DC).


Theoretical models for heterogeneity of base composition in DNA.


Pneumococcal spinal subdural abscess (a case report).


Perceptual memory for numerousness in "nonpsychotic schizophrenics".


MMPI scores for field-dependent and field-independent psychiatric outpatients.


Behavioral correlates of single-scale MMPI code types.


Motivation-hygiene correlates of mental health: an examination of motivational inversion in a clinical population.


Mechanism of bacterial transformation and transfection.


Swimming instruction for pre-school children.


Rupture of the heart. Report of a case with one week survival.


The cholesterol hypothesis and the coronary primary prevention trial.


Categorization of hospital emergency medical capabilities in Illinois: A statewide experience.


Hemangiosarcoma of breast.

Hemangiosarcoma of breast.


The view box.

The view box.


EKG of the month.

EKG of the month.


The changing role of neonatal nursing.

The changing role of neonatal nursing.


Editorial: Angina pectoris.

Editorial: Angina pectoris.


Educational programs for surgeon's assistants.


Essentials of an approved educational program for the surgeon's assistant.


Division is perilous.

Division is perilous.


Studies on the structure and function of the mammalian testis. V. Steroid metabolism by isolated interstitium and seminiferous tubules of the human testis.


A quantitative study of the fixation of acid phosphatase by formaldehyde and its relevance to histochemistry.


The structure of a high density lipoprotein (HDL3) from porcine plasma.


Spermiogenesis of Eledone cirrhosa Lamarck (Cephalopoda, Octopoda).


Synthesis and bioassays of a new dimethoxyalkylmercapto-1,4-benzoquinones.


The public health or community nurse--her duties and responsibilities in the new health service.


Tenth International Leprosy Congress Bergen, 1973. Reports of committees.


Pneumonia caused by a pneumococcus resistant to erythromycin and lincomycin. Case report.


X-ray of the month.

X-ray of the month.


Congress highlights and reflections.

Congress highlights and reflections.


On the regulation of tryptophan hydroxylase in brain.


5-Methoxytryptamine: a possible central nervous system transmitter.


Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drug therapy.


It's your committee and it's your future.


Clinical variations of cystic fibrosis.

Clinical variations of cystic fibrosis.


Electrical alternans. Case report and comments on its mechanism and diagnostic significance.


Association of oral microorganisms plaque, diet and dental caries in students.


Treating psoriasis of the scalp with a new corticosteroid lotion.


Lithium carbonate in the treatment of manic-depressive disorders: a follow up study.


Speech therapy for the mildly dysphasic patient: when is it indicated?


Rediscovery of Cushing's forceps.

Rediscovery of Cushing's forceps.


Abdominal wall abscess in an infant.

Abdominal wall abscess in an infant.


Rape.

Rape.


Surgical grand rounds: Hyperparathyroidism and pregnancy.


Epigastric pain and vomiting with or without a history of trauma.


The role of the social worker in the Community Hospital.


"What do you think of the concept of physician assistants? Would you ever use one? Why, or why not?".


Recent advances in the pathophysiology of asthma.


Fédération Dentaire Internationale Chronicle of the 61st Annual Session Sydney, Australia, 15th--20th July 1973.


Subcellular constituents of human placenta. II. Isolation and density distribution of lysosomes from first trimester tissue.


General analgesia and anesthesia in obstetrics.


The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies.


Inhibition of rat liver mitochondrial oxidative phosphorylation by sulfobromophthalein.


Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review.


Effects of alpha-adrenergic blocking agents on narcotic-induced analgesia.


New developments in glucose-6-phosphate dehydrogenase deficiency.


History of the Illinois Medical Journal.


Functional recovery after lesions of the nervous system. IV. Structural correlates of recovery in adult subjects. Changes in drug sensitivity during recovery of function after brain damage.


Oldest living Illinois physician: the remarkable Dr. Hill.


Personal dedications guide physicians. The oath of Hippocrates.


Neuromuscular dysfunctions of the external urinary sphincter.


Studies on cryptorchidism: a comparison of histological findings in the germinative epithelium before and after the second year of life.


An ADN approach to the open curriculum.

An ADN approach to the open curriculum.


The reappearance of immunologically reactive lymphocytes following termination of homograft tolerance.


The response of homograft-tolerant rats to allogeneic lymphocytes.


Tolerance induction to a heterotopic cardiac allograft in the irradiated reconstituted mouse.


Studies of various amphetamines, apomorphine and clonidine on body temperature and brain 5-hydroxytryptamine metabolism in rats.


Lithium and alpha-methyl-p-tyrosine prevent "manic" activity in rodents.


Chromosomal anomalies and central nervous system.


The differentiation pathway of T lymphocytes. Evidence for two differentiated cell types. Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells.


Sites of metyrapone inhibition of steroid biosynthesis by rat adrenal mitochondria.


Guanosine cyclic 3',5'-monophosphate and guanylate cyclase activity in guinea pig lung: effects of acetylcholine and cholinesterase inhibitors.


Brain 5-hydroxytryptamine and cyclic AMP in morphine tolerance and dependence.


Measurements of monoamine synthesis and turnover with special reference to 5-hydroxytryptamine.


Biotransformation of fluroxene.

Biotransformation of fluroxene.


Prospects and predictions for the cardiomyopathies.


Hepatic metabolism of halothane.

Hepatic metabolism of halothane.


A sample survey of dental knowledge, attitudes, behavior and needs among Scott County school children. I. The dental inspection.


Biotransformation of trichloroethylene.

Biotransformation of trichloroethylene.


Acetyl coenzyme A carboxylase. Subunit structure of the protomeric form of the avian liver enzyme.


Reaction mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Oxidation-reduction-active disulfides in the B1 subunit.


A simplified assay for coenzyme M (HSCH2CH2SO3). Resolution of methylcobalamin-coenzyme M methyltransferase and use of sodium borohydride.


Functional compartmentation of acetaldehyde oxidation in rat liver.


The use of psychotropic agents in heart disease.


Endo-beta-N-acetylglucosaminidase acting on carbohydrate moieties of glycoproteins. Purification and properties of the enzyme from Diplococcus pneumoniae.


Is the representation of the objective body-image in figure drawings related to the personality characteristics of the drawer?


Profile stability of a clinical rating scale.


Improved patient care.

Improved patient care.


Operating room assistants program.

Operating room assistants program.


The interaction of the antineoplastic drug thalicarpine with aniline hydroxylase and microsomal cytochrome of rat liver.


Mosquitoes: a public health threat in Arizona?


Butaperazine dimaleate metabolism.

Butaperazine dimaleate metabolism.


Enzyme organization in the proline biosynthetic pathway of Escherichia coli.


Effects of pipothiazine palmitate on CNS structures: neurophysiological and behavioral and behavioral correlations.


An electron microscopic and autoradiographic study of mesogleal organization and collagen synthesis in the sea anemone Aiptasia diaphana.


Induction of tyrosine aminotransaminase and ornithine decarboxylase in isolated perfused regenerating rat liver.


Effect of quasi-substrate on the monomer-dimer equilibrium of D-amino acid oxidase.


Evidence obtained by cathepsin digestion of microsomes for the assembly of cytochrome b5 and its reductase in the membrane.


Free autologous composite tendon grafts for division of both flexor tendons within the digital theca of the hand.


Pitfalls in histochemical localization studies of NADPH generating enzymes or enzyme systems in rat small intestine.


Comparison of the MMPI and the Mini-Mult with alcoholics.


Size and distribution of histochemical fibre types in masseter muscle of adults with different states of occlusion.


Partial purification of a carbon monoxide-binding hemoprotein reconstitutively active in fatty acid omega-hydroxylation from porcine kidney cortex microsomes.


The permeability to water of the cuticle of the larva of Opifex fuscus (Hutton) (Diptera, Culicidae).


Dipsogenic action of diazoxide: a pharmacologic analysis.


Control of norepinephrine synthesis in blood vessels and the effects of monoamine oxidase inhibition.


Variation of intra- and perisynaptic adrenergic transmitter concentrations with width of synaptic cleft in vascular tissue.


Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer.


Editorial: Unrefined antihistamine lode.


Estimation of the rate of 5-HT synthesis in the mouse brain by various methods.


Structure and assembly of bacterial surface layers composed of regular arrays of subunits.


Characterization of the adrenoceptors mediating the positive ino- and chronotropic effect of phenylephrine on isolated atria from guinea pigs and rabbits by means of adrenolytic drugs.


Glucose-6-phosphate dehydrogenase Toulouse. A new variant with marked instability and severe deficiency discovered in a family of Mediterranean ancestry.


Discriminative response control by d-amphetamine and related compounds in the rat.


Riboflavin and drug metabolism in adult male and female rats.


The interaction of 2-phenylisatogen and menadione with rat liver mitochondrial NADH dehydrogenase.


The nicotinamide nucleotide specificity of glutamate dehydrogenase in intact rat-liver mitochondria.


Intranuclear and intermicrosomal distributions of 3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase in rat ventral prostate.


Corticosteroidogenic responsiveness to adrenocorticotropin and dibutyryl cyclic AMP in isolated adrenal cells of hypophysectomized rats.


Transformation of testosterone into 17beta-hydroxy-5beta-androstan-3-one by Rana esculenta skeletal muscle.


Pigeon liver diacetyl reductase: purification and some properties.


Mitochondrial acetaldehyde dehydrogenase from Saccharomyces cerevisiae.


Purification and properties of glutamine synthetase from Bacillus stearothermophilus.


The effect of lesions of ascending noradrenaline pathways on sleep and waking in the rat.


Evidence for a specific phosphatidyl inositol transferring protein in rat brain.


Inhibition of the regenerative growth of central noradrenergic neurons by intracerebrally administered anti-NGF serum.


Glycosidases of marine invertebrates from Posiet Bay, Sea of Japan.


In virto adsorption of bile salts to food residues, salicylazosulfapyridine, and hemicellulose.


Central atropine-like toxicity in combined psychotropic drug administration.


Immune function and dysfunction in relation to aging.


Hydroperoxide peroxidase activity in liver microsomes.


Brain monoamines. Biosynthesis and fate.


Interpretation of effects of lesions on localization of brain monoamines.


The pediatrician in community dental health.


Structure-activity studies on the gamma-glutamyl cycle and its relationship to amino acid transport.


'Piggyback' chromatography: assay for guanylate cyclase in retina and other neural tissue.


"First-pass" metabolism of paracetamol in rat liver.


[A privilege is not a right].

[A privilege is not a right].


A comparison between the personality changes in certain forms of psychomotor and grand-mal epilepsy.


A comparison of antibiotic-sterilized, stent-mounted pulmonary and aortic valve allografts in the mitral region of dogs.


A comparison of the inhibitory effects of certain antiparkinsonian agents on dopamine accumulation into the rat striatum.


A hostility scale for form R of the MMPI.


A new method for detection of causative agents at various sites of air way in patients with respiratory infection.


A new variant of glucose-6-phosphate dehydrogenase deficiency hereditary hemolytic anemia, G6PD Cornell: erythrocyte, leukocyte, and platelet studies.


A nicotinamide-adenine dinucleotide assay utilizing liver alcohol dehydrogenase.


A preliminary clinical trial of Prazosin: a new oral antihypertensive agent.


A role for the pyridine nitrogen of reduced triphosphopyridine-nucleotide in the mechanism of action of isocitrate dehydrogenase.


A study of patient populations in New York City tropical disease clinics.


A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.


A survey of neuroendocrine phenomena in non-arthropod invertebrates.


A 3(17)beta-hydroxysteroid dehydrogenase in raterythrocytes. Conversion of 5alpha-dihydrotestosterone into 5alpha-androstane-3beta,17beta-diol and purification of the enzyme by affinity chromatography.


Accumulation and tissue distribution of mercury in the guinea pig during subacute administration of methyl mercury.


Action of clonidine on baroreceptor reflexes in conscious dogs.


Actions of atropine, hemicholinium-3, and physostigmine on chlorpromazine-induced changes in rat brain monoamines.


Activation of hexose monophosphate pathway in brain by electrical stimulation in vitro.


Activity of adrenal catecholamine-producing enzymes and their regulation after stress.


Acute and chronic morphine treatment and the hydroxylation of (1-14C)-L-tyrosine in the mouse brain. Tyrosine hydroxylase activity in slices of caudate nucleus was increased by morphine (100 mg/kg i.p.) administered to naive mice. During chronic treatment with morphine tolerance developed to this effect and 36 h after the final chronic morphine injection there was a decrease in enzyme activity in this area. There was no change in tyrosine hydroxylase activity in slices of diencephalon, brainstem or parietal cortex from either naive or morphine tolerant mice. There- fore, changes in tyrosine hydroxylase activity, measured in vitro, could account for the changes in dopamine synthesis, but not noradrenaline synthesis, produced by morphine in vivo.


Activity of gamma-glutamyl transpeptidase and other enzymes in the serum of sheep with liver or kidney damage.


Acute epiglottitis. A surgical emergency.


Aerobic and anaerobic glycolysis in the liver after hemorrhage.


Alcoholism--a general hospital meets the challenge.


Age differences in the baroreceptor response of rats.


All in a day's work: the case for ambulatory surgery.


Altered norepinephrine synthesis of splanchnic vessels in neurogenic hypertension.


Amino acid aminotransferase activity of rat heart.


Ammonia detoxifying mechanisms of rainbow trout altered by dietary dieldrin.


An electron microscope autoradiographic study of the neuronal and extraneuronal localization of labeled amine in the heart of the bat after administration of tritiated norepinephrine. The localization of labeled amine in the heart of the bat after administration of tritiated norepinephrine (NE) was studied by means of electron microscope autoradiography. Monoamine oxidase was inhibited so that the distribution of amine in both neuronal (Uptake(1)) and extraneuronal (Uptake(2)) sites could be analyzed. Labeling was nonrandom in both the atrial and ventricular myocardium. The highest relative specific activity was found in neural processes which showed morphological criteria of terminal adrenergic axons. Analysis of the distribution of label around the labeled axonal varicosities indicated that the radioactive amine was more concentrated peripherally than centrally in these structures. Label was also found over cardiocytes in both atrium and ventricle. The pattern of this labeling indicated that the radioactive amine was associated with myofilaments. In the ventricle, I bands were most heavily labeled, indicating a probable association of radioactive amine with thin filaments. Labeling was prevented by administration of phenoxybenzamine and decreased only in cardiocytes by normetanephrine. The nonrandom distribution of labeled amine within cardiocytes supports the view that Uptake(2) represents not only a second mechanism of inactivation of the sympathetic neurotransmitter, but may also be involved in the mediation of some of the action of NE on cardiac muscle.


An appraisal of the functional significance of the inhibitory effect of long chain acyl-CoAs on mitochondrial transports.


An experimental model of hormone dependent immunodeficiency disease.


An improved procedure for the enzymatic analysis of prostaglandins in the nanogram range.


An inhibitory innervation at the gastroduodenal junction. Transverse muscle strips, 2-mm wide, were cut serially from the gastroduodenal junction in opossums, cats, dogs, and man. Electrical field stimulation with trains of rectangular current pulses of 0.5 ms in all opossums, all cats, some dogs, and the one human specimen induced relaxation in strips from the thickened circular muscle proximal to the mucosal junction. In some opossums weak relaxations also occurred in the first few strips below the mucosal junction. All other strips contracted or showed no response. This relaxation in opossums was abolished by tetrodotoxin but was not affected by antagonists to adrenergic and cholinergic transmission, nor by tripelennamine, methysergide, pentagastrin, secretin, cerulein, or cholecystokinin. Optimal frequency for stimulus-relaxation was 12 Hz. Chronaxie was 0.85 ms. The junctional strips also showed greater resistances to stretch than those remote from the junction. With apparent species variations, the junctional muscle possesses a nonadrenergic inhibitory innervation which is either absent or unexpressed in adjacent muscle of stomach and duodenum. This suggests the existence of a distinctive inhibitory neural control mechanism for pyloric muscle.


Analgesia produced by clonidine in mice and rats.


An investigation of the relationship between beta-adrenoceptor blockade and plasma practolol concentration in man.


Anesthetic interaction with a model cell membrane: expansion, phase transition, and melting of the lecithin monolayer.


Antagonistic effects of apomorphine and haloperidol on rat striatal synaptosomal tyrosine hydroxylase.


Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). 1 Peptide 401, a potent mast cell degranulating factor from bee venom, substantially inhibited the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED(50) of 401 was c. 0.1 mg/kg. The anti-inflammatory effect was assessed by measurement of the increased (125)I-albumin content of an injected site in comparison with an uninjected contralateral site.2 Peptide 401 also suppressed the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins).3 Other comparable mast cell degranulating agents (48/80 and melittin) showed little evidence of anti-inflammatory activity when tested at comparable dosage on turpentine arthritis and carrageenin oedema.4 The anti-inflammatory effects were not abolished by pretreatment with mepyramine and methysergide, which abolished the increased vascular permeability produced by local injection of 401.5 The anti-inflammatory action of 401 was not affected by regional denervation or pretreatment with phenoxybenzamine, and was reduced but not abolished by adrenalectomy.6 Measurement of skin temperature, fractional extraction of (86)Rb and blood flow in perfused mesentery gave no evidence that the anti-inflammatory action of 401 was due to reduced tissue perfusion.7 It is concluded that 401 may exert its anti-inflammatory action directly by making the vascular endothelium anergic to phlogistic stimuli.


Anti-lymphocytic antibodies and marrow transplantation. 3. Effect of heterologous anti-brain antibodies on acute secondary disease in mice.


Application of orthogonal functions to spectrophotometric analysis. The combined polynomial method.


Assays for narcotic antagonist activity in rodents.


Association between increase in cyclic AMP and subsequent induction of tyrosine hydroxylase in rat adrenal medulla. Experiments with swimming stress.


Antiasthmatic drugs I: pathophysiological and clinical pharmacological aspects.


Bacteriophage-induced ribonucleotide reductase systems. T5- and T6-specific ribonucleotide reductase and thioredoxin.


Bamethan A competitive betamimetic drug.


Beta adrenergic and anti-arrhythmic effects of cardiopep, a newly isolated substance from whole bee venom.


Application of Viega's simplified indices for estimating the prevalence of dental caries in Thai children.


Beta cell monoamines: further evidence for their role in modulating insulin secretion.


Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus.


Biological properties of the nerve growth factor.


Blockade by burimamide of the effects of histamine and histamine analogues on cardiac adenylate cyclase.


Biosynthesis of adrenal catecholamines during adaptation of rats to immobilization stress.


Bluetongue and related viruses in Ibadan, Nigeria: isolation and preliminary identification of viruses.


Bone-marrow transplantation in combined immunodeficiency disease.


Beta-adrenergic blockade and sensitivity to exogenous histamine in bronchial asthma.


Aspects of chronic low back pain.

Aspects of chronic low back pain.


Carbon-monoxide oxidation in cell-free extracts of Clostridium pasteurianum.


Brain and liver intracellular compartmental redox states in hypoxia, hypocapnia and hypercapnia.


Capsular types and outcome of bacteremic pneumococcal disease in the antibiotic era.


Cardiac stimulant action of extracts of coelenterates on rat atria.


Cardiovascular beta-adrenergic receptor blocking activities of 1-(7-indenyloxy)-3-isopropyl-aminopropane-2-ol hydrochloride (YB-2) and its optical isomers.


Central hypothermia by 2-deoxy-D-glucose: antagonism by alpha-adrenergic activation.


Cardiovascular stimulant responses following intravenous administration of MJ 9465-2 (2-amino-4-(4-chlorophenyl)-2-imidazoline-HBr) in the dog: mechanisms of action.


Changes in beta-adrenoceptor-blocking activity produced by chemical modifications in the practolol molecule.


Characteristics of transmitter release at regenerating frog neuromuscular junctions. 1. A study was made of the onset of transmission and the characteristics of transmitter release from regenerating nerve terminals in frog muscle fibres.2. Soon after transmission had been restored, some junctions were found which responded to nerve stimulation with only subthreshold end-plate potentials.3. The evoked transmitter release had a non-linear dependence on the external calcium concentration, like that seen at normal junctions.4. The synaptic delay was only slightly longer than normal, and the amplitudes of single quantum potentials evoked by nerve stimulation seemed to have a normal distribution.5. The mean amplitude of the spontaneous miniature end-plate potentials was often substantially smaller than the mean amplitude of the evoked quantal potentials at a given end-plate. Some of these small spontaneous potentials were due to transmitter release from the axon terminal. Possible explanations for this discrepancy in size of spontaneous and evoked potentials are discussed. Two to three weeks after reinnervation began, the amplitude of the spontaneous miniature end-plate potentials returned to normal.


Characteristics of B cell tolerance induced with T-independent polysaccharides.


Characterization of Salmonella typhimurium strains sensitive and resistant to methionine sulfoximine. Methionine sulfoximine inhibits the growth of Salmonella typhimurium at a concentration of 50 muM, and the addition of glutamine, but not glutamate, is sufficient to overcome this inhibition. The analogue causes 50% inhibition of glutamine synthetase activity at 2 to 4 muM and of glutamate synthase at 2 to 3 mM when these enzymes are assayed in vitro. No inhibition of glutamate dehydrogenase activity is observed at analogue concentrations as high as 50 mM. Two mutants selected for their resistance to methionine sulfoximine inhibition have a partial growth requirement for glutamine and a reduction in the glutamine synthetase and glutamate synthase activities. The sensitivity of the remaining glutamine synthetase activity in these mutants to methionine sulfoximine inhibition appears unaltered, and the lesions conferring the analogue resistance may not affect glutamine synthetase directly.


Chemical messengers in development: a hypothesis. The hypothesis that physiological and developmental regulatory mechanisms are similar has been presented. Well-known developmental systems chosen illustrate the capability of the model to suggest a simple mechanism underlying the effects on development of a diverse group of chemicals. This hypothesis might be applied to other systems including the induction of the lens, limb regeneration, and the induction of the head of hydra (124). I have proposed this hypothesis not only because it permits consideration of a complex and varied array of experimental observations as reflections of a simple basic biochemical mechanism, but because recent technical advances in instrumentation and methods allow it to be directly tested. The fluorescent antibody method for the cytochemical measurement of cyclic nucleotides provides a means for investigating changes in the concentrations of cyclic nucleotides in developing cells and could also be used to detect neurotransmitters in developing cells. Similarly, the scanning electron microscope in the emitted x-ray mode provides a method for measuring changes in the content and distribution of cations within developing cells. The hypothesis presented here suggests pleasing asceticism on the part of eukaryotes. It suggests that simple derivatives of metabolites, including neurotransmitters and cyclic nucleotides, are linked together as regulatory molecules throughout the eukaryotes. The neurotransmitters are suggested to have a more general role in information transmission in eukaryotes than is generally accepted. They are hypothesized to have progressed during evolution from being intracellular messengers to a role as intercellular messengers for the relatively slow communication of developmental informatbn; and, finally, this process has culminated with their participation in the rapid intercellular communication mediated by nerves. The thought that the complex pictures of physiological regulation and of the construction of a complex multicellular organism like man might be painted with so few colors is quite satisfying.


Chloroplast structure and function. A report of the British Photobiology Society meeting held in London on 19 October 1973.


Clinical trial of a new beta-receptor blocking agent, tolamolol, in angina pectoris.


Comparative involvement of dopamine and noradrenaline in rate-free self-stimulation in substania nigra, lateral hypothalamus, and mesencephalic central gray.


Comparative physiology of hemorrhage. A study of adrenergic receptor stimulation and blockade in pigeon and mammal.


Compartmentation of dopamine in rat striatum.


Compression characteristics of powders: radial die wall pressure transmission and density changes.


Control of organ blood flow following hemorrhage.


Correlates of accuracy in personality assessment.


Covariance of myocardial cyclic AMP and calcium during beta-adrenergic stimulation in vivo.


Comparative evaluation of injectable chlorpromazine and piperacetazine.


Critical period for the development of spontaneous hypertension in rats.


Cyclic nucleotide metabolism in normal and proliferating epidermis.


Cyclic nucleotides and smooth muscle.

Cyclic nucleotides and smooth muscle.


Cyclorphan and related compounds.

Cyclorphan and related compounds.


Deafness and acupuncture.

Deafness and acupuncture.


Defferentiation between the "critical period," the "activation period" and the "potential activation period" for neurohumoral stimulation of LH release in proestrous rats.


Degeneration secretion of saliva in the rat following sympathectomy. 1. After previous extirpation of the superior cervical ganglion saliva was found to flow from the cannulated submaxillary duct of rats under chloralose anaesthesia. The secretion started 13-14.5 hr after sympathectomy, increased gradually in rate and then slowed down and ceased, lasting for about 12 hr.2. Injection of alpha- or beta-adrenoreceptor blocking drugs reduced the flow and a combination of both types of drugs abolished it. It is concluded that the secretion was caused by noradrenaline released from the degenerating nerves, and that the phenomenon is an example of the degeneration activity described in other preparations as an effect of section of post-ganglionic autonomic nerves.3. A similar, but less pronounced, secretion was found in the parotid gland of the rat.


Delayed hypersensitivity and essential hypertension. Delayed hypersensitivity against arterial wall components as a pathogenetic factor in essential hypertension.


Dental caries prevalence in seven soil areas of New Zealand.


Dental caries-experience in three generations of families.


Dental health of migrant agricultural workers.


Dental health of junior dental students.


Depression and hostility.

Depression and hostility.


Cytochrome P-450 difference spectra: effect of chemical structure on type II spectra in mouse hepatic microsomes.


Differences in the cardiac and pressor responses to propranolol of rats and guinea pigs.


Different types of immunological unresponsiveness.


Differential spectrophotometric determination of phenylephrine in eye-drops: the deltaAr method.


Cytochrome P-450 difference spectra. Type II interactions in insecticide-resistant and -susceptible houseflies.


Distribution of exogenous acetaldehyde in cow adrenal medulla chromaffin granules.


Distinct subpopulations of thymus-dependent lymphocytes. Tracing of the differentiation pathway of T cells by use of preparatively electrophoretically separated mouse lymphocytes.


Distribution of marker enzymes between mesosomal and protoplast membranes.


Double-blind study in psychopathic behavior disorders (clozapine and pericyazine).


Editorial: The new orchestration.

Editorial: The new orchestration.


Drug therapy reviews. Rational use of psychotropic drugs. I. Hypnotics.


Effect of adrenergic activation on collateral coronary blood flow.


Effect of acetaldehyde on the isolated, non-working guinea-pig heart: independence of the coronary flow increase from changes in heart rate and oxygen consumption.


Effect of alpha-adrenergic blockers on naloxone-binding in brain.


Effect of hemorrhagic shock on gluconeogenesis, oxygen consumption and redox state of perfused rat liver.


Effect of protein-free diet on mitotic activity of transplanted splenic lymphocytes.


Effect of phenothiazine neuroleptic drugs and tricyclic antidepressants on phosphodiesterase activity in rat cerebral cortex.


Effect of lipid peroxidation and its inhibitors (BHA, BHT) on the drug metabolizing enzymes in rat liver microsomes.


Effect of reserpine on catechol-O-methyl transferase in rat submaxillary gland.


Effect of serum albumin upon the response of the rat isolated superfused anococcygeus muscle to catecholamines and to nerve stimulation.


Effective hospital management through the corporate structure.


Effect of single and repeated administration of clozapine on the metabolism of dopamine and noradrenaline in the brain of the rat.


Effects of a bacteriocin produced by Streptococcus faecalis var. zymogenes (E1) on susceptible microorganisms.


Effects of alpha- and beta-receptor blockade on systolic time intervals.


Effects of burimamide, an antagonist of H-2 histamine receptors, in the gastric fistula dog.


Effects of catecholamines, exercise, and nitroglycerin on the normal and ischemic myocardium in conscious dogs. The effects of isoproterenol, norepinephrine, dobutamine, exercise, and nitroglycerin on left ventricular diameter, pressure, velocity of shortening, dP/dt, dP/dt/P, arterial pressure, left circumflex coronary blood flow, and coronary vascular resistance were examined in healthy conscious dogs with normal coronary perfusion and in the same animals after moderate global ischemia had been induced by partial occlusion of the left main coronary artery. In the normal nonischemic heart, all interventions improved left ventricular performance, as evidenced by increases in dP/dt/P and velocity at the same or lower left ventricular end-diastolic diameter. Interventions, which in the normal heart caused large increases in heart rate and myocardial contractility, e.g. isoproterenol and exercise, or which decreased coronary perfusion pressure, e.g. nitroglycerin or isoproterenol, elicited paradoxical responses in moderate global ischemia, i.e., left ventricular enddiastolic diameter and pressure rose, and dP/dt/P and velocity fell substantially. On the other hand, norepinephrine, which increased coronary perfusion pressure along with myocardial contractility but did not increase heart rate, improved left ventricular function. Dobutamine, which did not alter heart rate or arterial pressure substantially while improving myocardial contractility, produced an intermediate response between that of norepinephrine and isoproterenol in the presence of moderate global myocardial ischemia. Thus, interventions that increase myocardial O(2) requirements, by increasing heart rate and myocardial contractility without augmenting coronary perfusion pressure, can produce a paradoxical depression of ventricular function in the presence of global myocardial ischemia.


Effects of chronic nicotine administration and age on various neurotransmitters and associated enzymes in male Fischer-344 rats.


Effects of dopamine on the superior cervical ganglion of the rabbit. 1. The effects of dopamine on isolated rabbit superior cervical ganglion were investigated with intracellular recording techniques.2. Dopamine (10(-5)-10(-3)M) depressed the amplitude of the excitatory post-synaptic potential (e.p.s.p.) and blocked impulse transmission.3. Dopamine (10(-4)M) induced a slight (2-5 mV) post-synaptic hyperpolarization without altering membrane conductance.4. The post-synaptic membrane sensitivity to acetylcholine (ACh) applied iontophoretically was not affected by dopamine.5. Dopamine decreased the frequency of miniature excitatory post-synaptic potentials (m.e.p.s.p.s) in a high K(+) solution, with no change in the amplitude of m.e.p.s.p.s.6. Dopamine reduced the quantal content of the e.p.s.p. in a low Ca(2+) and high Mg(2+) solution, but had no effect on the quantal size.7. The ganglionic blocking effect of dopamine was antagonized by phenoxybenzamine, but not by propranolol.8. The results show that the ganglionic depressant effect of dopamine is exerted primarily through an alpha-adrenoceptive site at the presynaptic nerve terminal.


Effects of local anesthetics, antihistamines, and glucocorticoids on peripheral blood flow and vascular smooth muscle.


Effects of noradrenaline pump blockers on its uptake by synaptosomes from several brain regions; additional evidence for dopamine terminals in the frontal cortex.


Effects of single doses of alprenolol and two cardioselective beta-blockers (H 87-07 and H 93-26) on exercise-induced angina pectoris.


Effects of the optical isomers of the narcotic antagonist analgesic pentazocine on brain and heart biogenic amines.


Effects of tetraphenylboron (TPB) on the autonomic nervous system.


Effects of Gymnodinium breve toxin on the smooth muscle preparation of guinea-pig ileum. 1 The effects of Gymnodinium breve neurotoxin (GT) on smooth muscles were studied using the guinea-pig isolated ileum.2 The toxin caused strong spasmogenic effects at 1-4 mug/ml, characterized by prolonged tonic contraction with superimposed pronounced pendular movements. Tachyphylaxis was observed upon administration of successive doses.3 Atropine blocked the contractile response elicited by GT, whereas mepyramine and hexamethonium failed to do so. These findings tentatively suggested a cholinergic involvement at a post-ganglionic site of action.4 In the presence of tetrodotoxin the effects of GT were abolished, excluding direct action of the toxin on the smooth muscle.5 It is concluded that GT exerts its spasmogenic effects through stimulation of the post-ganglionic cholinergic nerve fibres.


Effects of 2,4-dinitrophenol and N,N'-dicyclohexylcarbodiimide on cell envelope-associated enzymes of Escherichia coli and Salmonella enteritidis.


Efflux of prostaglandins in right lymphatic duct lymph following induced intravascular coagulation and inhibited fibrinolysis in the dog.


Elevated acetylcholine contents in mouse brain after treatment with bicuculline and picrotoxin.


Enzymatic catalysis of the reversible sulfitolysis of glutathione disulfide and the biological reduction of thiosulfate esters.


Enzymatic reduction of 5-deazariboflavine from reduced nicotinamide adenine dinucleotide by direct hydrogen transfer.


Enzyme assays at the single cell level using a new type of microfluorimeter.


Enzyme of polymorphisms of erythrocytes in psoriasis.


Enzymes of the homogentisate ring-cleavage pathway in cell suspension cultures of higher plants.


Enzymes of the gamma-glutamyl cycle in the choroid plexus and brain.


Ergot alkaloids and some problems of the physiology of their formation.


Evidence for direct alpha-adrenoceptor stimulation of effector neurons in cardiovascular centers by clonidine.


Enzymatic conjugation of foreign chemical compounds by rabbit lung and liver.


Evidence for extranoradrenergic dopamine-beta-hydroxylase activity in rat salivary gland.


Experimental studies on facilitative and inhibitory factors for epileptogenic focus formation.


First international congress. World Federation of Neurological Nurses.


Evidence for redistribution of filtrate among nephrons after beta-adrenergic stimulation and blockade.


Feedback inhibition of glutamine synthetase from green pea seeds.


Factors influencing observed beta-adrenergic receptor antagonism in guinea-pig trachea.


First prison admissions with juvenile histories and absolute first offenders: frequencies and MMPI profiles.


Fluorinated tryptophans as substrates and inhibitors of the ATP--(32P)PPi exchange reaction catalysed by tryptophanyl tRNA synthetase.


Formation and metabolism in vitro of 5,6-epoxides of cholesterol and beta-sitosterol. The formation of 5alpha,6alpha- and 5beta,6beta-epoxides of cholesterol and beta-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols. The beta-epoxides were formed in three- to fourfold excess over the alpha-epoxides. Both cholesterol epoxides were efficiently converted by a microsomal hydrolase into the 3beta,5alpha,6beta-triol. The conversion was less extensive with beta-sitosterol epoxides, especially the beta-epoxide. The possible biological significance in the formation of the sterol epoxides and the triols was evaluated by their ability to inhibit the microsomal cholesterol 7alpha-hydroxylase. Only the cholesterol epoxides and especially the beta-epoxide were active in this respect.


Functional and structural proteins of the nervous system.


Future trends in ambulatory short-stay surgery.


Functional significance of neuronal and extraneuronal transmitter uptake in rat salivary glands. The effect of protriptyline and normetanephrine.


Glucose-6-phosphate dehydrogenase from Caulobacter crescentus.


Glutamate dehydrogenase of Tetrahymena.

Glutamate dehydrogenase of Tetrahymena.


Growth of Venezuelan encephalitis virus and disapperance of coxsackie A, Rous sarcoma, herpes simplex and vaccinia viruses following inoculation of Aedes aegypti and other mosquitoes.


Help-seeking attitudes and severity of psychological distress.


Guanyl cyclase in chick embryo brain cell cultures: evidence of neuronal localization.


Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization.


Hepatitis B antigen in urban-caught mosquitoes.


High-affinity uptake of (3H)gamma-aminobutyric acid into frog spinal cord slices.


Host preference in Aedes (Stegomyia) mosquitoes in Uganda. II. Studies on indoor and outdoor biting and resting behaviour with special reference to Aedes aegypti L.


Histological and histochemical changes in the jejunal mucosa in ulcerative colitis.


Hydroxymethylation of the benzene ring. Microsomal hydroxymethylation of benzo(alpha)pyrene to 6-hydroxymethylbenzo(alpha)pyrene.


Imidazole and penicilloylation in penicillin allergy.


Identification of the major enzymic activities of the mitochondrial inner membrane in terms of their migration in sodium dodecyl sulfate polyacrylamide gel electrophoresis.


Immune response to pneumococcal polysaccharide in inbred lines of chickens.


Immunological diagnosis of human filariases: present possibilities, difficulties and limitations.


Immunological study of carbon tetrachloride-mediated induction of tyrosine aminotransferase in rat liver.


Improved method for salicylazosulfapyridine analysis and partial characterization of impurities in commercial salicylazosulfapyridine.


Importance of immediate gram-stain examination of the sputum in infections of the lower respiratory tract.


Improving medical service in long term care facilities.


In intensive care units: flexibility--the key to critical care nursing.


Indirect pathogenicity of Gram-negative bacilli in the bronchi: the value of colistin aerosol.


Increased incidence of urethane induced lung adenomata by autosensitized lymphocytes. The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours.


Induction of tyrosine aminotransferase and depression of protein synthesis in rat liver by a tryptophan-free mixture of amino acids.


Hypertensive encephalopathy: Mechanisms, clinical features, and treatment.


Induction of rat liver enzymes by polychlorinated biphenyls (PCBs) in dependence on the dose and chlorine content.


Inflammatory bowel disease.

Inflammatory bowel disease.


Influence of acute pretreatment with delta 9-tetrahydrocannabinol on the LD50 of various substances that alter neurohumoral transmission.


Inhibition of a minor pathway of L-dopa metabolism in the intestinal lumen using a decarboxylase inhibitor (Ro 4-4602).


Influence of the alternate complement pathway in opsonization of several bacterial species. In normal human serum chelated with magnesium (10 mM) and ethylene glycotetraacetic acid (10 mM) (MgEGTA), the classical pathway of complement activation is blocked; however, the alternate pathway of complement activation is intact. Diplococcus pneumoniae, Staphylococcus albus, Streptococcus viridans, Streptococcus faecalis, and Serratia marcescens were opsonized in normal human serum containing 10 mM MgEGTA. In contrast, Staphylococcus aureus and Pseudomonas aeruginosa were poorly opsonized in human serum chelated with 10 mM MgEDTA. Therefore certain bacterial species appear to require the classical pathway of complement activation to be opsonized and other bacterial species utilize the alternate pathway of complement activation.


Inhibition of energization of Salmonella typhimurium membrane by zinc ions.


Inhibition of motor transmission in the vas deferens of the rat by adrenergic neuron blocking agents and beta-adrenoceptor blocking agents having local anaesthetic effects.


Inhibition of prolyl hydroxylase by collagen.


Insulin, its chemistry and biochemistry.


Interaction between the predator Toxorhynchites brevipalpis and its prey Aedes aegypti. In a circumscribed area in Tanzania where the predacious larvae of Toxorhynchites brevipalpis were particularly abundant, it was found that water-filled tires and tins containing Toxorhynchites larvae had fewer larvae of Aedes aegypti than those without the predator larvae. The peaks of infestation with Toxorhynchites larvae occurred almost a month later than the peaks of A. aegypti infestation. Cannibalism was observed among the predator larvae in these containers.


Interaction of luteinizing hormone and its subunits in corpus luteum supernatant.


Interactions of chlorpheniramine ethanol combinations: acute toxicity and antihistaminic activity.


Interference by tryptophan analogues of an in vitro assay for liver tyrosine transaminase activity.


Intracellularly injected aequorin detects transmembrane calcium flux during action potentials in an identified neuron from the terrestrial slug, Limax maximus.


International seminar research on alcohol, drugs and driving.


Involution of the thymus dependent lymphoid system.


Investigations into the positive inotropic effect of clondine in isolated hearts.


Joint cartilage and the homograft reaction.


Isolation of an ATP-Pi exchangease from lysolecithin-treated electron transport particles.


Kainic acid: a powerful neurotoxic analogue of glutamate.


Leiomyosarcoma of the foot presenting as an arteriovenous fistula.


Interaction of primary amines with a mixed-function amine oxidase isolated from pig liver microsomes.


Letter: Considerations in the drug treatment of drug-induced and other acute dyskinesias.


Letter: Fatal aplastic anemia with piperacetazine therapy.


Letter: Fatal insect stings.

Letter: Fatal insect stings.


Letter: Lawn mower injuries.

Letter: Lawn mower injuries.


Letter: Tricyclic antidepressants and phenothiazines.


Leukocytoclastic vasculitis.

Leukocytoclastic vasculitis.


Lymphographic findings in granulomatous inflammations and connective tissue diseases. Differential diagnosis between these diseases and lymphomas.


Liver enzymes and pathology in Hodgkin's disease.


Malignant degeneration of cryptorchid testes following orchiopexy.


Manipulation of sexual physiology by brain stimulation in insects.


Meandering catheter.

Meandering catheter.


Lysosomal physiology in Tetrahymena. 3. Pharmacological studies on acid hydrolase release and the ingestion and egestion of dimethylbenzanthracene particles. The ingestion of (14)C-labeled 9,10-dimethyl-1,2-benzanthracene particles, the extracellular release of acid phosphatase, ribonuclease, and alpha-glucosidase, and the egestion of preingested dimethylbenzanthracene particles by Tetrahymena taken from logarithmically growing cultures and resuspended in a dilute salt solution were followed in the presence of several pharmacologic agents. Serotonin, caffeine, and, to a lesser extent, dibutyryl cyclic AMP increased the rate of particle ingestion, but did not alter the rate of release of the three acid hydrolases studied. Added catecholamines did not affect either particle ingestion or acid hydrolase release, but particle ingestion was inhibited by the catecholamine antagonists, dichloroisoproterenol, desmethylimipramine, reserpine, and phenoxybenzamine. These drugs also increased the release of acid phosphatase and ribonuclease in 5-h incubations. Desmethylimipramine acted within 1 h to increase acid hydrolase release, but the effect of dichloroisoproterenol developed more slowly and was secondary to a change in cellular content of the hydrolases. Desmethylimipramine increased the energy of activation for the release of acid phosphatase, while dichloroisoproterenol did not. Both of these drugs enhanced the egestion of preingested dimethylbenzanthracene particles, supporting the view that acid hydrolase release occurs through a cytoproct egestion mechanism. Particle ingestion was also inhibited by colchicine, vinblastine, and cytochalasin B, but these agents had no effect on acid hydrolase release, thus further differentiating the properties of the ingestion mechanism from those of the egestion mechanism. It appears that both microtubules and microfilaments play a role in the ingestion process and that this process may be controlled in part by a cyclic AMP-mediated serotoninergic and adrenergic system.


Measurement of outcome: a proposed scheme.


Mechanism of stimulation of the hexose monophosphate shunt of erythrocytes by pyruvate.


Mechanisms of substrate binding with glutamine synthetase. Equilibrium isotope exchanges with the ovine brain, pea seed, and Escherichia coli enzymes.


Mechanisms and defects of the phagocytic systems of defense against infection.


Medical management of angina pectoris.

Medical management of angina pectoris.


Metabolic and endocrine functions of rats conditioned to Noble-Collip drum trauma.


Metabolic changes in "frozen-clamped" livers of rats caused by ingestion of polychlorinated biphenyls.


Metabolic changes in hemorrhagic shock.

Metabolic changes in hemorrhagic shock.


Metabolic regulation in enzyme-deficient red cells.


Metabolism of cortisol by fetal rat liver explants.


Metabolic, hormonal and enzymatic functions of rats during recovery from injury.


Microbial production of pharmacologically active compounds other than antibiotics.


Modified nitroprusside-colorimetric determination of antazoline salts in some pharmaceutical preparations.


Morphological and cytochemical studies of synapses formed in culture between isolated rat superior cervical ganglion neurons.


MMPI and clinical scales compared.

MMPI and clinical scales compared.


Nectar sources of Wisconsin mosquitoes.

Nectar sources of Wisconsin mosquitoes.


Metabolism of 3-(2-dimethylaminoethyl)benzo(b)thiophene in vitro and in vivo in the rat.


Neurovirulence of vaccinia viruses for mice.


New host records of Stempellia magna, a microsporidan parasite of mosquitoes.


Morphine metabolism. I. Evidence for separate enzymes in the glucuronidation of morphine and p-nitrophenol by rat hepatic microsomes.


New spasmolytically effective basic carbanilates.


N-hydroxylation of 4,4'-diaminodiphenylsulphone in liver microsomes and in vivo.


Nitrite reductase from A. fischeri: amino acid composition and hydrodynamic properties.


Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum.


Normal and experimentally modified development of buds in Cassiopea (phylum Coelenterata; class Scyphozoa).


NADP malate dehydrogenase, acetyl-CoA synthetase and ATP citrate lyase in the developing rat brain.


Observations on the discharged granules from guinea-pig bone marrow basophils following anaphylaxis.


On the first steps of lactate oxidation by bakers' yeast L-(plus)-lactate dehydrogenase (cytochrome b2).


Occurrence of adenyl cyclase activity in human erythrocytes.


On facilitation of transmitter release at the toad neuromuscular junction. 1. The time dependence of the increase in amplitude (facilitation) of a second end-plate potential (e.p.p.) elicited within 10-100 msec of a preceding e.p.p. was examined at neuromuscular junctions in sartorius muscles of toads. Facilitation was defined by two characteristics, initial facilitation and the time constant of its exponential decay.2. The time constant of decay of facilitation was longer at lower temperatures and the Q(10) was 4.3 in the range 10-25 degrees C. There was no significant effect of temperature on initial facilitation.3. Ouabain (10(-4)-10(-3)M), lithium substitution for sodium, sodium azide (5 mM) and N-ethylmaleimide (NEM, 0.1 mM) initially had no effect on initial facilitation or the decay of facilitation. After some time, they all caused a longer time constant of decay of facilitation and a depression of initial facilitation.4. It was concluded that the decay of facilitation is not directly dependent on active transport of sodium ions, calcium efflux, ATP-dependent movements of calcium or mitochondrial uptake of calcium following an action potential.5. Ouabain, lithium, sodium azide, and NEM all caused an increase in transmitter release. This effect, and the late effects on facilitation, were thought to be due to an increase in intracellular calcium concentration in nerve terminals.6. No relationship was found between the quantal content of e.p.p.s (range, 0.8-100) and initial facilitation, or the time constant of decay of facilitation.7. Substitution of strontium for calcium ions caused a marked prolongation of the time constant of decay of facilitation, and a depression of initial facilitation.8. The results were consistent with the hypothesis that the time constant of decay of facilitation is related to the rate of disappearance of an ;active' complex of calcium (CaA) which, of itself, is not sufficient for transmitter release. It is suggested that an action potential produces CaA which decays with the time constant of facilitation and CaS, a short-life complex of calcium which decays with the time constant of the phasic release of transmitter. The release of transmitter is proportional to some function of [CaA] and [CaS].


On the influence of exogeneous cyclic AMP (3',5'-adenosine monophosphate) on amyloid formation in casein-treated C3H mice.


Nitrogen oxidation in ferrihaemoglobin formation.


On the mechanism of action of thyroxin, an amino acid analog of tyrosine.


Oral leukocytes and gingivitis in the primary dentition.


Osmotic fragility of liposomes as affected by antihelmolytic compounds.


On the role of the adrenergic receptors for extraneuronal amine uptake and retention in rat salivary glands in vitro.


Parental MMPIs and certain pathological behaviors in children.


Partial separation and interconversion of NADH- and NADPH-linked activities of purified glyceraldehyde 3-phosphate dehydrogenase from spinach chloroplasts.


Partially treated meningitis.

Partially treated meningitis.


Pentazocine analgesia and regional rat brain catecholamines.


Permeability of films of ethyl cellulose and PEG to caffeine.


Personality characteristics of state hospital Patients' Rights Office visitors.


Persistence of Diplococcus pneumoniae after influenza virus infection in Macaca mulatta. Exposure of monkeys to aerosols of influenza virus followed later by aerosols of Diplococcus pneumoniae resulted in persistence of the bacteria in the upper respiratory tract for an average of 28 days. Examination of selected tissues for pneumococci revealed that pneumococci were widely disseminated throughout the respiratory tract at 3 and 7 days after exposure, but were cleared from lower respiratory tissues and were found mainly in tonsils, oropharynx, and posterior nasopharynx after 14 days.


Personality correlates of renal dialysis patients and their spouses.


Pertussis vaccination.

Pertussis vaccination.


Pharmacology of a new beta-adrenoceptor blocking agent, The 15219.


Pharmacotherapy of schizophrenia.

Pharmacotherapy of schizophrenia.


Philip Ellman lecture. Immunological aspects of systemic diseases of the lungs.


Photoinhibition of isolated complexes I, II, and 3 of beef heart mitochondria.


Photophosphorylation and the 518 NM absorbance change in tightly coupled chloroplasts.


Possible role of adrenergic mechanisms in the systemic anti-inflammatory activity of acetic acid in rats.


Practice management: The professional corporation--advantages and disadvantages.


Powder mixing in the tableting of fenfluramine hydrochloride: evaluation of a mixer.


Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated both by alpha- and beta-adrenoceptors.


Prediction of drug oxidation rates in man: lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol.


Primary care in the academic medical centers: A report of a survey by the AAMC.


Potentiation of drug-initiated adrenal tyrosine hydroxylase induction by diazepam.


Problems interpreting the significance of multiple form patterns of rat liver tyrosine aminotransferase.


Proceedings: Adrenergic receptors in heart muscle: similarity of apparent affinities of beta-blockers for receptors mediating adenyl-cyclase activity, inotropic and chronotropic effects of catecholamines.


Pharmacokinetics and biotransformation of chlorpropamide in the rat and dog.


Proceedings: Antagonism by ICI 66082 of the effects of electrical stimulation on the right ansa subclavia of the dog.


Physiological disposition of 2,6-dimethyl-4-benzyl-4-demethylrifampicin in rats, mice, and dogs.


Proceedings: Chemical mediators and gonadotrophin secretion.


Proceedings: Coexistence of monoamines in adrenergic synaptic vesicles.


Proceedings: Compartmentalization of water in rat testis.


Proceedings: Compartmentation of synaptic monoaminergic vesicles.


Proceedings: Drug interaction on driving skills as evaluated by laboratory tests and by a driving simulator.


Proceedings: Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in the human testicular function.


Piperacetazine vs. thioridazine for the control of schizophrenia in outpatients.


Proceedings: Natriuresis, kaliuresis and urinary volume changes induced by cholinergic and adrenergic stimulation of the septal area of the rat brain.


Proceedings: The effect of various putative neurotransmitters on the release of CRH from the hypophysiotrophic hypothalamus in vitro.


Proceedings: The effect of certain drugs on central synapses.


Production of an inflammatory exudate containing prostaglandins.


Properties of the assimilatory nitrate reductase from Aspergillus nidulans.


Production of colony-stimulating factor in mixed leucocyte cultures.


Psychiatric problems of the aged.

Psychiatric problems of the aged.


Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum.


Purification and properties of pyridine nucleotide-independent L-lactate dehydrogenase from Polyporus circinatus. Cell extracts of Polyporus circinatus grown on lactate catalyze the reduction of 2,6-dichlorophenolindophenol by l-lactate without the participation of nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate. The enzyme has been purified 78-fold and was homogenous by disc gel electrophoresis. The optimal pH was found to be 6.7. The Michaelis constant for l-lactate was 5.9 x 10(-4) M and the oxalate inhibition constant was 1.5 x 10(-4) M. The nature of the prosthetic group is discussed.


Purification and properties of reconstitutively active and inactive adenosinetriphosphatase from Escherichia coli. The Mg(2+)- and Ca(2+)-stimulated ATPase (EC 3.6.1.3; ATP phosphohydrolase) (bacterial coupling factor) was purified from two strains of E. coli by two different procedures: (a) method of Nelson, Kanner, and Gutnick [Proc. Nat. Acad. Sci. USA (1974) 71, 2720-2724] and (b) a modified procedure described in this paper. The ATPase purified from E. coli K12 (lambda) by the first procedure had 4 subunits (alpha, beta, gamma, and epsilon). It did not bind to a deficient membrane, nor did it reconstitute ATP-driven transhydrogenase activity. Our modified procedure (b) yielded 5 subunits (alpha, beta, gamma, delta, and epsilon). This ATPase could bind to a deficient membrane and reconstitute ATP-driven transhydrogenase. This finding suggests that the delta subunit is required for the reaction with the membrane. The molecular weight of the 4-subunit ATPase was significantly lower than that of the 5-subunit ATPase, as judged by equilibrium centrifugation. The specific ATPase activities of both preparations were about the same. These two procedures were also applied to E. coli ML308-225.


Purification and properties of NADP-dependent 17 beta-hydroxysteroid dehydrogenase solubilized from porcine-testicular microsomal fraction.


Quantitative TLC of salicylazosulfapyridine.


Quantum chemical studies of the metabolism of the inhalation anesthetics methoxyflurane, enflurane, and isoflurane.


Radiosensitivity of T and B lymphocytes. II. Effect of irradiation on response of T cells to alloantigens.


Rapid eye movement (REM) sleep deprivation, stress and intermediary metabolism.


Rapid mixed lymphocyte culture test based on relative increase in protein synthesis.


Reaction mechanism of L-glutamate dehydrogenase. Transient complexes in the oxidative deamination of L-glutamate catalyzed by NAD(P)-dependent L-glutamate dehydrogenase.


Recovery of medically important microorganisms from Apollo astronauts.


Regulation of lipid synthesis in cultured animal cells.


Regulation of catecholamine synthesis in rat brain synaptosomes.


Regulation of protein synthesis by cyclic AMP.


Relationship between locus of control, self-report and nonobtrusive measures of anxiety.


Radical production in amine oxidation by liver microsomes.


Relationship of density of Culiseta melanura mosquitoes to infection of wild birds with eastern and western equine encephalitis viruses.


Relationships between locus of control and MMPI scales among alcoholics: a replication and extension.


Relative vasoconstrictor potencies of norepinephrine, alpha-methylnorepinephrine and octopamine.


Replicated actuarial correlates for three MMPI code types in juvenile delinquency.


Resolved: that the present system of prenatal care is inadequate. A debate.


Role of roots, hormones and light in the synthesis of nitrate reductase and nitrite reductase in rice seedlings.


Role of the lysine-sensitive aspartokinase 3 in the regulation of DAP-decarboxylase synthesis in Escherichia coli K 12.


Scale equivalence and profile similarity of the Mini-Mult and MMPI in an outpatient clinic.


Sea-anemone collagen: isolation and characterization of the cyanogen-bromide peptides.


Relaxation therapies and neurosis: a central fatigue interpretation.


Search for phosphorylated forms of fatty acid synthesis enzymes in the living animal.


Selected pharmacological studies of Luffa operculata.


Self-evaluations of antidepressants.

Self-evaluations of antidepressants.


Sensitivity tests on individual human cancers to pick active drug therapy.


Seminiferous tubular immaturity and testicular neoplasia.


Serum-gamma-glutamyltranspeptidase (gamma-GT) and aspartate-aminotransferase (AspAT) activities in adult cattle with chronic Fasciola hepatica infection.


Significance of FEBS to world biochemistry.


Sinusitis and otitis in children.

Sinusitis and otitis in children.


Simulated car driving influenced by cannabis and alcohol.


Smith-Lemli-Opitz syndrome in an adult.

Smith-Lemli-Opitz syndrome in an adult.


Skin reactions to systemic drug therapy.


Social role performance and psychopathology among recently hospitalized and nonhospitalized mothers. II. Correlates with life stress and self-reported psychopathology.


Some aspects of evolutionary pharmacology.


Sodium cromoglycate (cromolyn sodium). II. Allergic rhinitis and other conditions.


Sex-dependent differences in drug metabolism in the rat. I. Temporal changes in microsomal drug-metabolizing system of the liver during sexual maturation.


Special report: hospitals and inflation.


Sex-dependent differences in drug metabolism in the rat. 3. Temporal changes in type I binding and NADPH-cytochrome, P-450 reductase during sexual maturation.


Sex-dependent differences in drug metabolism in the rat. IV. Effect of morphine administration.


Specific inhibition of cytokynasis in E. coli by chemically unrelated compounds.


Sex-dependent differences in drug metabolism in the rat. II. Qualitative changes produced by castration and the administration of steroid hormones and phenobarbital.


Splanchnic blood flow in experimental shock.


Stenosis of the ureter caused by periarteritis.


Stability of suspensions of rat liver microsomes quick-frozen with liquid nitrogen and stored at -85 degrees.


Steroid 17,20-lyase from testis microsomes: participation of NADPH cytochrome c reductase.


Stoichiometry of drug metabolism in maturing male rats.


Some aspects of microsomal N- and C-oxygenation of aromatic amines.


Stress and hormonal intervention in the graft-versus-host response.


Structural correlates of immune microenvironment.


Special article. The role of beta-adrenergic blockade in myocardial infarction.


Studies on guanylate cyclase. A new assay method for guanylate cyclase and properties of the cyclase from rat brain.


Studies on malaria and responses of Anopheles balabacensis balabacensis and Anopheles minimus to DDT residual spraying in Thailand. I. Pre-spraying observations.


Studies on the agglutinin specificities and blood group O(H)-like activities in extracts from the molluscs Pomacea paludosa and Pomacea urceus.


Studies on some metabolic effects of dopa and dopamine in the rat.


Studies on the biogenesis of smooth endoplasmic reticulum membranes in hepatocytes of phenobarbital-treated rats. II. The site of phospholipid synthesis in the initial phase of membrane proliferation. The specific activity of the acyltransferases of smooth microsomes of rat liver rose threefold by 12 h after injection of phenobarbital, while the activity of the acyltransferases of the rough microsomes rose slightly to peak at 3-4 h, and subsequently fell. The latter rise was abolished by treatment of the animal with actinomycin D or puromycin, while that of the smooth microsomes was unaffected. Incorporation of [(14)C]glycerol into phospholipid of smooth microsomes was elevated 100% by phenobarbital, while that of the rough microsomes was elevated 15%, and this could be accounted for by exchange between the microsomal phospholipids. The phospholipid/protein ratio of the smooth microsomes rose 1.5 times 3-4 h after injection of phenobarbital, while that of the rough microsomes fell slightly. The specific activity of NADPH cytochrome c reductase and NADPH diaphorase rose first in the rough microsomes, and subsequently in the smooth microsomes at a time coinciding with the return of the phospholipid/protein ratio to the control level. The rise in phospholipid/protein ratio was unaffected by actinomycin D or puromycin. These results indicate that the proliferating smooth membranes are the site of phospholipid synthesis, and that the phospholipid/protein ratio of these membranes may change independently.


Studies on the eyes of New Zealand parrot-fishes (Labridae).


Studies on the influence of T cells in antibody responses of mice to S3 and DNP-lysine-S3.


Studies on flavonoid metabolism. Excretion of m-hydroxyphenylhydracrylic acid from (plus)-catechin in the monkey (Macaca iris sp.).


Studies on the mechanism of inhibition of drug biotransformation by cyclic adenine nucleotides.


Substrate inhibition of pigeon liver fatty acid synthetase and optimum assay conditions for over-all synthetase activity.


Studies on the mechanism of the lung toxicity of paraquat: comparison of tissue distribution and some biochemical parameters in rats and rabbits.


Sulthiame: evaluation as an anticonvulsant.


Sulfisoxazole as chemoprophylaxis for recurrent otitis media. A double-blind crossover study in pediatric practice.


Studies on the effects of methylmercury on ethylmorphine N-demethylase and aniline hydroxylase activities and on the conversion of cytochrome P-450 to cytochrome P-420.


Suppression by alpha-methyltyrosine of ethanol-induced locomotor stimulation: partial reversal by L-dopa.


Surface characteristics of gelatin microcapsules by scanning electron microscopy.


Survey on driver behaviour alcohol and drug.


Synthetic 14-hydroxymorphinan narcotic antagonists.


Test-induced anxiety as a function of psychopathology.


Taurine conjugation of fenclofenac in the dog.


T-cell regulation of T-cell responses to antigen.


The amino acid sequence of human myoglobin and its minor fractions.


The activation of bovine pineal tryptophan 5-monooxygenase.


The antagonism between cholinomimetic agonists and beta-adrenoceptor stimulants. The differentiation between functional and metaffinoid antagonism.


The binding of sulphonylureas to serum albumin.


The choroidal tapetum lucidum of Latimeria chalumnae.


The cellular basis of immunological recovery in nude mice after thymus grafting.


The dangers of therapy without assessment: a case study.


The distribution of Streptococcus mutans on the teeth of two groups of naval recruits.


The effect of chlorcyclizine on cholesterol metabolism in mice.


The effect of endocrinological manipulations on tyrosine hydroxylase and dopamine-beta-hydroxylase activities in individual hypothalamic nuclei of the adult male rat.


The effect of monoamine oxidase inhibitors on the rectal temperature of the rat.


The effects of 2H2O on mammary glucose-6-phosphate dehydrogenase.


The effect of pyridine nucleotides on the activity of NADP-dependent isocitrate dehydrogenase from brain cytosol.


The fate of intravenous (3H)glycopyrrolate in man.


The first ten years of FEBS: retrospect and prospect.


The flagyl analogue of nicotinamide adenine dinucleotide.


The foundation and early years of FEBS.

The foundation and early years of FEBS.


The heroin problem: Some strategic aspects.


The hospital's responsibility to visitors.


The immunological properties of haptens coupled to thymus-independent carrier molecules. I. The characteristics of the immune response to dinitrophenyl-lysine-substituted pneumococcal polysaccharide (SIII) and levan.


The induction of a cellular immune reaction against self-antigens present in the thymus.


The influence of a ganglion-blocking agent on experimental liver injury.


The influence of environmental factors and physiological stage on flight patterns of mosquitoes taken in the vehicle aspirator and truck, suction, bait and New Jersey light traps.


The influence of methylene blue on the respiratory metabolism of the reticulocyte.


The legal implications of the extended roles of professional nurses.


The management of propoxyphene poisoning.


The inhibition by beta-adrenoceptor blocking agents of calcium uptake into and efflux from isolated sarcoplasmic vesicles.


The mosquitoes of the Santa Cruz faunal subarea of the Southwest Pacific (Diptera: Culicidae).


The megathrombocyte as an index of platelet production.


The normality of the distribution in the sample when Viegas' simplified index for dental-caries experience is used.


The non-nurse manager: new partner for professionals.


The influence of cytochrome P-450 induction on the metabolic formation of 455-NM complexes from amphetamines.


The pathologist's assistant.

The pathologist's assistant.


The pathophysiology and treatment of migraine.


The problem of postural hypotension.

The problem of postural hypotension.


The repression-sensitization dimension and self-cognition in psychiatric inpatients.


The proportion of lymphocytes capable of recognizing strong transplantation antigens in vivo.


The role of autolysins in cell death.

The role of autolysins in cell death.


The role of malate in the cleavage of cholesterol side-chain in the course of progesterone biosynthesis in human term placenta.


The role of malic enzyme in Aspergillus nidulans.


The significance of amino acid inhibition of NADP-linked glutamate dehydrogenase in the physiological control of glutamate synthesis in Candida utilis.


The role of NADH in uncoupled microsomal monoxygenations.


The specificity of the rat-liver cholesterol 7alpha-hydroxylase.


The pharmacologic basis of antihypertensive therapy: The role of vasodilator drugs.


The structure of nitrones derived from amphetamines.


The oxidative cleavage of alkyl-nitrogen bonds in micro-organisms.


The MMPI: a descriptive measure of psychopathology in abusive parents.


The synthesis of N6-(6-aminohexyl)-NAD+ and its application to affinity chromatography.


The OR clinical co-ordinator: a supervisor plus.


The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450.


The role of nitrogen oxidation in the excretion of drugs and foreign compounds.


Tolerance in ovum fusion derived tetraparental mouse chimaeras.


Transplantation of haemopoietic stem cell (HSC) concentrates for treatment of immune deficiency disease.


Treatment of asthma. Recent advances.

Treatment of asthma. Recent advances.


Treatment of hypertension in the elderly.


Ulcerative proctitis.

Ulcerative proctitis.


Undergraduate marijuana and drug use as related to openness to experience.


Traits of pain patients: the low-back "loser".


Viruslike particles of Glossina fuscipes fuscipes Newst. 1910.


Validity of the 133 xenon method for measuring coronary blood flow. Comparison with coronary sinus outflow determined by an electromagnetic flowprobe.


When disaster strikes.

When disaster strikes.


Yersinia enterocolitica in small rodents. 1. Pilot study in two wildlife areas.


Zinc-induced paracrystalline aggregation of glutamine synthetase.


6-Phosphogluconate dehydrogenase and enzymes of the Entner-Doudoroff pathway in Neisseria.


2-(2,4-dichlorophenoxy) phenylacetic acid (fenclofenac): one of a novel series of anti-inflammatory compounds with low ulcerogenic potential.


Utilization of a paramedic and a mobile ear clinic to provide otologic care in remote areas.


[Effect of unilateral cryptorchidism on testicular carbohydrate metabolism (author's transl)].


A controlled study of the effect of corticosteroids on immediate skin test reactivity.


A dental health study of children attending dental hospitals in Rangoon and Birmingham.


A hospital program toward physical fitness.


A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan.


A physician's assistant program for South Dakota.


A quantitative lymph node weight assay for allogeneic interactions in the rat.


A retrospective longitudinal study of caries prevalence during and 7 years after free dental care at school in Finland.


A standard approach to therapy.

A standard approach to therapy.


A syndrome resembling pheochromocytoma following a stroke. Report of a case.


Acute adverse reactions to psychoactive drugs, drug usage, and psychopathology.


Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factor.


Adrenergic mechanisms in canine hindlimb circulation.


Adrenocorticotrophic hormone and the control of adrenal corticosteroidogenesis.


Adrenodoxin reductase, the flavoprotein component of adrenal mitochondrial steroid hydroxylases. I. Purification and certain characteristics.


Adrenodoxin reductase, the flavoprotein component of adrenal mitochondrial steroid hydroxylases. II. Functional aspects.


A psychological questionnaire predictive of myocardial infarction: results from the Kaiser-Permanente epidemiologic study of myocardial infarction.


Adrenolytic and vasodilator therapy.

Adrenolytic and vasodilator therapy.


Advanced prosthodontic education: projections by the American College of Prosthodontists, 1973 annual session.


An evaluation of a hierarchical method of describing the pattern of dental caries attack.


Alteration of tyrosine aminotransferase multiple form patterns by antisickling agents and a decomposition product of antitumor agents.


An instrumental method of quantitative estimation of the activity of oxidative enzymes.


An oral health survey of Western Samoans.


Anaerobic and aerobic energy metabolism in the larvae (tetrathyridia) of Mesocestoides corti.


Angiography in collagenous disease of the kidney.


Analysis of the influence of selected neurotropic agents on hepatic metabolism in relation to endotoxicosis.


Antihistaminic action of nicotinamide.

Antihistaminic action of nicotinamide.


Antitrachoma activity of streptovaricin.


Association between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse sublines. Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes. These sublines also showed marked differences in their fighting behavior after a 2-week isolation period. Balb/cJ mice fought immediately after presentation of an intruder mouse, while Balb/cN mice did not fight at any time during the test. Heterozygous progeny behaved more like the Balb/cN (non-fighters). Analysis of F(2) mice suggested that the differences in fighting behavior were determined by a single gene, with fighting being recessive.


Binding of adrenergic beta-receptor antagonists to human serum albumin.


Binding of two adrenergic beta-receptor antagonists, alprenolol and H 93-26, to human serum proteins.


Anti-5HT activity of mephenesin (Myanesin) on the isolated guinea-pig ileum.


Canadian law vs. Catholic hospitals.

Canadian law vs. Catholic hospitals.


Biosynthesis and degradation of nicotinamide coenzymes in the myocardium.


Caries experience among children in Copenhagen.


Caries-preventive effect of dentifrice containing 2percent sodium monofluorophosphate in a natural fluoride area in Denmark.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1974.


Cellular biochemical assessment of steroid activity.


Changes in activity of enzymes metabolizing glucose 6-phosphate during development of the basidiomycete Schizophyllum.


Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes. The rat popliteal node graft-vs.-host assay was shown to depend on the presence of parental T cells in the inoculum. Antialloantisera raised in F(1) hybrid rats against alloantibodies of one parent directed at transplantation antigens of the other parent displayed some or all of the following specific effects on parental T cells: They inhibited local GvH by purified T-cell suspensions; they blocked the capacity of GvH-reactive cells to adsorb onto fibroblast monolayers of the relevant genotype; together with complement, they killed GvH-reactive cells.


Biliary excretion and enterohepatic recirculation of methaqualone in the rat.


Characterization of minicells (nuclei) obtained by cytochalasin enucleation.


Colorimetric determination of antazoline in some pharmaceutical preparations with sodium nitrite.


Biochemistry of affective disorders. (A review of the literature).


Chemotherapy of delirium tremens: a survey of physicians' preferences.


Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report.


Conformational change with temperature and thermostability of glutamine synthetase from Bacillus stearothermophilus.


Content analysis of 27 anxiety inventories and rating scales.


Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline.


Contractlity in Spirostomum provides for nonelectrogenic calcium regulation through energy-dissipative metabolic processes in the absence of membrane excitability.


Control of the pacemaker system of the nerve-net in the sea anemone Calliactis parasitica.


Comparison of tasks and activities in physician-Medex practices.


Crystallization of E. coli aspartokinase I-homoserine dehydrogenase I.


Current trends in the introduction of new drugs.


Cyclic adenosine monophosphate and clinical medicine. 2. Carbohydrate and lipid metabolism.


Dental fluorosis and caries in high-fluoride districts in Sweden.


Control by phytochrome of the level of nicotinamide nucleotides in the cotyledons of the mustard seedling.


D-Galactose dehydrogenase from Pseudomonas fluorescens. Purification, properties and structure.


Differences in antigen handling by peritoneal macrophages from the Biozzi high and low responder lines of mice.


Dihydroergotamine: a potent biological amplifer of sulphonylureas.


Conversion disorders: a review of research findings.


Drug therapy of hypertension: what we have, what we need, what we expect.


Editorial: Alcoholism and the mass media.


Drug therapy. Benzodiazepines (first of two parts).


Editorial: Newborn identification procedures.


Editorial: 1. Advanced emergency care delivery systems and the anesthetist.


Dieldrin metabolism to cis-dihydroaldrindiol and epimerization of cis- to trans-dihydroaldrindiol by rat liver microsomes.


Edmund Andrews: the forgotten pioneer of Chicago urology.


Determination of serum morphine by the spin-label antibody technique.


Effect of catecholamines on cardiac metabolism.


Effect of beta-adrenergic stimulation on myocardial adenine nucleotide metabolism.


Effect of divalent cations on ferredoxin-linked electron transport in chloroplasts.


Drugs, dry mouth, and dental disease. A case report.


Effect of fluroxene anesthesia on the cornary circulation, myocardial oxygen consumption and cardiac contractility in dogs.


Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens.


Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man. Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.


Effect of isoproterenol on water diuresis.


Effect of pharmacologic conditioning on sulfadiazine toxicity and concentrations in plasma.


Effect of psychopharmacological agents on the gonads of female rats.


Effect of sodium hydroxybutyrate on behavior of mice after prolonged isolation.


Effect of some agents in the adenyl cyclase system on electrical activity of the toad urinary bladder.


Effect of unilateral castration of the testis in artificial cryptorchidism.


Effect of ethanol on synthesis and active accumulation of gamma-aminobutyric acid in rat brain slices.


Effectiveness and toxicity of immunosuppressive agents: inhibition of the rat popliteal node graft-vs.-host reaction.


Effects of a GABA--derivative (BA-34647) on spasticity. Preliminary report of a double-blind cross-over study.


Effects of brief relaxation training on autonomic response to anxiety-evoking stimuli.


Effects of suckling and food deprivation on the activity of citrate enzymes in the liver of the rat.


Effects of the porphyrogenic agent 2-allyl-2-isopropylacetamide on the hydroxylation of testosterone in rat liver microsomal fraction.


Effects of thyroid state on adrenoceptor properties.


Effects of NADPH, NADP+, succinate and cyclic AMP on progesterone synthesis in subcellular fractions of rabbit ovarian interstitial tissue.


Electron microscopic observation of the aboral organ of Ctenophora. I. The gravity receptor.


Electron transport carriers involved in nitrogen fixation by the coliform, Klebsiella pneumoniae.


Emergency treatment of petroleum distillate and turpentine ingestion. A comparative study was made of pulmonary complications following the use of ipecac syrup and gastric lavage for hydrocarbon ingestion. The selected 255 patients had chest radiography when first seen and again two to five days later. Of these patients 74 or 29% had been treated with ipecac syrup, 41 or 16% by gastric lavage. On follow-up radiographs 19% of the ipecac-treated group were unchanged or worsened, compared with 39% of the lavage group, suggesting that pneumonitis was significantly less severe in the ipecac-treated patients. Use of ipecac is preferred over gastric lavage for alert patients who have ingested an excessive amount of hydrocarbon.


Endocrine role of the lung in disease.

Endocrine role of the lung in disease.


Energization of energy-dependent transhydrogenase of Escherichia coli at a second site of energy conservation.


Enzyme histochemistry of the human ovary.


Epidemiological investigations of the respiratory tract bacteriology in patients with cystic fibrosis.


Exchange of neurotransmitter amino acid at nerve endings can simulate high affinity uptake.


Eye changes following phenothiazine administration.


Exogenous energy sources for spermatozoa in cervical mucus of the cow at oestrus.


EKG of the month.

EKG of the month.


Fat metabolism in higher plants. Properties of the palmityl acyl carrier protein: stearyl acyl carrier protein elongation system in maturing safflower seed extracts.


Five-day perfusion of canine kidneys: a postulated effect of steroids.


Fluorescence studies of nucleotides binding to diphtheria toxin and its fragment A.


Foreign medical apparatus for obstetrics and gynecology.


Further studies on the alteration of analgesic receptor-antagonist interaction induced by morphine.


Evaluation of physician's assistants in Gilchrist County, Florida.


Giant axonal neuropathy. A clinically and morphologically distinct neurological disease.


Glutamine amido transferase in yeast: changes in activity during the cell cycle.


Goals of the World Medical Association. Protecting the freedom of doctors. Raising the standard of ethics.


Glutathione turnover in the kidney; considerations relating to the gamma-glutamyl cycle and the transport of amino acids. The overall turnover of glutathione in kidney and liver was determined in studies in which L-[(14)C]glutamate was administered to mice. Turnover was much more rapid (about 5 times greater) in kidney than in liver. Studies were also carried out in which 5-oxo-L-[(14)C]proline was administered; the first order rate constants for glutathione synthesis from 5-oxoproline in liver and kidney were not far from those found for synthesis of glutathione from glutamate in these tissues. The findings are in accord with the fact that the activities of the enzymes of the gamma-glutamyl cycle are much higher in kidney than in liver. The findings of high turnover of glutathione in kidney and the rapid utilization of 5-oxoproline by this organ for glutathione synthesis are consistent with the function of the gamma-glutamyl cycle in vivo and the proposed role of gamma-glutamyl derivatives in amino-acid transport.


Graft-versus-host and cytotoxic activity of rat thoracic duct lymphocytes fractionated by zonal centrifugation after culture on allogeneic fibroblasts.


Graft-versus-host reaction in F 1 recipients in the absence of donor (parental) cell proliferation.


Guidelines in the drug treatment of angina pectoris.


G6PD kuanyama: a new variant of human erythrocyte glucose-6-phosphate dehydrogenase showing slower than normal electrophoretic mobility.


Help for rural hospitals: the travelling rehab. team.


Haemorrhagic and permeability increasing effects of 'Bothrops jararaca' and other Crotalidae venoms as related to amine or kinin release.


Handling of bioactive materials by the lung (second of two parts).


High-dose penicillin therapy and pneumococcal pneumonia.


Histamine receptors in extra- and intracranial arteries.


Hypertension as a community problem.

Hypertension as a community problem.


Ideational components of anxiety neurosis.


Immunity, emotions and stress with special reference to the mechanisms of stress effects on the immune system.


Hydroxylations in biosynthesis and metabolism of bile acids.


In vitro induction by phenobarbital of drug monooxygenase activity in mouse isolated small intestine.


In whom we trust: a busy time for boards.


Induction of glutamine synthetase in cultures of embryonic neural retina. Comments on the use of actinomycin D.


Interpretations of DMF registrations of Norwegian recruits with emphasis on previous treatment experience.


Influence of parental lymphoid cells on the production of 19S and 7S antibodies in F1 hybrid mice.


Inhibition of glucose 6-phosphate dehydrogenase by palmitoyl coenzyme A.


Irreversible binding of ethynylestradiol metabolites to protein: lack of methylation by S-adenosyl-methionine.


Kinetics of prolytic events during red cell lysis induced by sea anemone nematocyst venom.


Letter: Addictive drugs and alcoholism.

Letter: Addictive drugs and alcoholism.


Letter: Beta-adrenergic blocking agents in renal failure.


Letter: Gamma-glutamyl transpeptidase in alcoholism.


Letter: Danger of saline emetics in first-aid for poisoning.


Letter: Infant morbidity conference.

Letter: Infant morbidity conference.


Letter: Interference from serum separators in gas-chromatographic drug analysis.


Letter: Nomenclature and EC number of gamma-glutamyltransferase.


Intracellular distribution of 10-formyl tetrahydrofolic acid synthetase in spinach leaves.


Lincomycin and clindamycin colitis.

Lincomycin and clindamycin colitis.


Lipogenesis in aminonucleoside-induced nephrotic syndrome.


Localization of intra-abdominal testes by selective testicular arteriography: a case report.


Local effect of intranasal beclomethasone dipropionate aerosol in perennial rhinitis.


Malic enzyme inhibition by pregnenolone in bovine corpora lutea.


Lymphocyte receptors for antigen.

Lymphocyte receptors for antigen.


Management of flexor spasms with Lioresal.


Marine invertebrate origin of a reactant to mammalian T cells.


Measurement of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in erythrocytes by use of a centrifugal analyzer.


Medical legacy of Apollo.

Medical legacy of Apollo.


Metabolism of benz(a)anthracene epoxides by rat-liver.


Modifications of ovarian and follicular contractility by amines. A mechanism involved in ovulation?


Mosquito susceptibility levels to seven new insecticides and their comparative toxicity to the guppy, Poecilia reticulata, in Bangkok, Thailand.


National statistics on caries and oral hygiene derived from the Danish Child Dental Health recording system.


Necrotizing vasculitis and ulcerative colitis.


New evidence for the role of the Sertoli cell and spermatogonia in feedback control of FSH secretion in male rats.


Menarcheal age and personality: the choice of a statistical test of relationship.


New long latency bulbospinal evoked potentials blocked by serotonin antagonists.


Nitrate and ammonium ion-selective electrodes as sensors. I. In bacterial growth curves for isolation of nitrate and nitrite reductases from Escherichia coli.


Occurrence of Uranotaenia unguiculata Edwards, 1913 (Diptera, Culicidae) in Czechoslovakia.


October is Immunization Action Month.

October is Immunization Action Month.


Modification of adrenergic block by noradrenaline low temperature and sodium deficiency.


On the absence of cysteine in glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides.


On the differences in the sensitivity of coupling sites of submitochondrial particles to phospholipases A, C and and D.


Morphine metabolism. II. Studies on morphine glucuronyltransferase activity in intestinal microsomes of rats.


Metabolism and disposition of hydralazine-14C in man and dog.


On the problem of diphenylhydantoin-induced seizures. An experimental approach.


Opticianry, optometry, and ophthalmology: an overview.


On the spectral intermediate at 440 nm formed during mixed function substrate oxidation.


Optimized determination of gamma-glutamyltransferase by reaction-rate analysis.


Oral health status and treatment needs in a disadvantaged, rural population in Norway.


Oral manifestations of IgA deficiency.

Oral manifestations of IgA deficiency.


Organic hydroxylamine derivatives. X. Structural analogues of gamma-aminobutyric acid (GABA) of the isoxazole enol-betaine type. Synthesis of 5,6,7,8-tetrahydro-4H-isoxazolo (4,5-D) azepin-3-ol zwitterion and 4,5,6,7-tetrahydroisoxazole (4,5-c) pyridin-3-ol zwitterion.


Organ weights and tyrosine aminotransferase levels in the rat during adaptation to periodic fasting.


Personal history of Paget's disease. Osteitis deformans with several unusual features and their control.


Parental awareness of the dental needs of 5-year-old children in the West Midlands, England.


On the mechanism of photosynthetic oxygen reduction by isolated chloroplast lamellae.


Personality characteristics of heroin addicts: a response to Gendreau and Gendreau.


Phosphorylation of tyrosine aminotransferase in vivo.


Phylogeny and correlations of aldehyde oxidase, xanthine oxidase, xanthine dehydrogenase and peroxidase in animal tissues.


Physician assistants at Kaiser: distinctive patterns of practice.


Platelet aggregation in asthmatic and normal subjects.


Pleistophora milesi, a new species of microsporida from Maorigoeldia argyropus Walker (Diptera: Culicidae) in New Zealand.


Potassium-induced release of the diuretic hormones of Rhodnius prolixus and Glossina austeni: Ca dependence, time course and localization of neurohaemal areas.


Present treatment of manic states.

Present treatment of manic states.


Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats.


Presidential address: The Endocrine Society.


Primary ovarian pregnancy.

Primary ovarian pregnancy.


Probability of congenitally missing teeth: results in 1,191 children in the Burlington Growth centre in Toronto.


Prevention by uncouplers of lipophilic chelator inhibition at three sites of mitochondrial electron transport.


Proceedings: Failure of burimamide and (15S)-15-methyl prostaglandin E2 to prevent histamine-induced gastric mucosal hyperaemia in the rat.


Proceedings: The cardiovascular effects of dobutamine, a selective inotropic catecholamine.


Proceedings: The inhibitory action of GABA and melatonin on the release of corticotrophin-releasing hormone from the rat hypophysiotrophic area in vitro.


Prospectus: the prevention of bacteremic pneumococcal pneumonia. A conservative appraisal of vaccine intervention.


Prolonged survival of AKR mice following allogeneic bone marrow transplantation.


Pseudohermaphroditism, nephron disorder and wilms' tumor: a unifying concept.


Psychological measurements in Psychopharmacology. Introduction.


Psychological correlates of sleep habits reported by healthy young adults.


Psychic fatigability, its features and drug therapy.


Psychologic implications of scrotal sac and testes for the male child.


Psychological study of patients with coronary heart disease with unexpectedly long survival and high level function.


Pyridine-2,6-dicarboxylic acid (dipicolinic acid) formation in Bacillus subtilis. I. Non-enzymatic formation of dipicolinic acid from pyruvate and aspartic semialdehyde.


Quality control of NADH. Evaluation of methods for detection of inhibitors and specifications for NADH quality.


Quantitative electromyographic findings in some collagen diseases.


Rapid induction of prolactin secretion by 3-iodo-L-tyrosine.


Rational use of psychotropic drugs. II. Antianxiety agents.


Recording system for the Danish Child Dental Health Services.


Regulation of the physician assistant in Massachusetts.


Regulation of dinitrogen fixation in intact Azotobacter vinelandii.


Rehabilitation of the patient with chronic low back pain.


Relation between social drug use-abuse and dental disease in California, U.S.A.


Pyridine nucleotides: basis for the hypotensive action of triphosphopyridine nucleotide.


Relative abilities of parental thymus and spleen cells to induce graft-versus-host reactions and enhance antibody formation in F1 hybrid mice.


Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors.


Renin suppression.

Renin suppression.


Root alkaloids of Rauwolfia oreogiton.

Root alkaloids of Rauwolfia oreogiton.


Reactions of a monospecific antiserum to ferredoxin-NADP+-reductase with chloroplast preparations.


Salicylate poisoning.

Salicylate poisoning.


Serotonin-induced muscle weakness.

Serotonin-induced muscle weakness.


Sex-linked attenuation of the graft-versus-host reaction: effect on pathologic features, including tumor induction.