Bronchoprovocative tests (BPT) in clinical and experimental allergy.


The effect of proteolytic enzymes and hyaluronidase on the intracellular beta- and gamma-metachromatic granules and the matrix of rat epiphyseal cartilage.


Evaluation of the outcome of pregnancy in threatened abortion by biochemical methods. The predictive efficacy of plasma level tests of progesterone, human placental lactogen (HPL) activity, serum protein-bound iodine (S-PBI), and triiodothyronine uptake, and urinary levels of estrone and human chorionic gonadotropin (HCG) in  evaluating the outcome of pregnancy in 75 cases of threatened abortion between Weeks 7-26 of pregnancy was studied.  The results for each method, at Weeks 10-13, in groups with favorable and unfavorable outcome were significantly different (p less than .001).  The best predictions of an unfavorable outcome were obtained by the urinary HCG and plasma HPL tests (82%, 79% correct results), while the lowest predictive accuracy was with the S-PBI and serum triiodothyronine uptake tests (50%, 38% correct  results).  Correct assessment of a favorable outcome, for the methods, ranged from 74%-94% correct results; urinary estrone and plasma progesterone showed the best results, while the lowest efficacy was given by the plasma HPL test.


On the origin of RNA tumor viruses.

On the origin of RNA tumor viruses.


The relationship between genes and polytene chromosome bands.


Fluorescent antibody study of the gram-positive anaerobic cocci. Fluorescent antibody conjugates were prepared from five species of anaerobic cocci commonly isolated from human infections. When tested with homologous and heterologous cells these conjugates were found to be highly specific. There was no evidence of a common genus antigen. Peptococcus magnus conjugates detected a species-specific antigen; cross-reactions with Peptostreptococcus anaerobius were readily eliminated by absorption. The conjugates from Peptococcus asaccharolyticus, Peptococcus prevotii, Peptostreptococcus, anaerobius, and Peptostreptococcus intermedius displayed a high degree of strain specificity. Occasional cross-reactions were detected with homologous strains, suggesting the presence of common antigens, but no attempt was made to determine the number of different serotypes in these species.


Alteration of ribosomal precursor RNA in Novikoff hepatoma cells by 5-azacytidine. Studies on methylation of 45S and 32S RNA.


Plasma proteins in meconium from normal infants and from babies with cystic fibrosis.


Renin and hypertension in childhood.

Renin and hypertension in childhood.


Proceedings: Antigen catabolism in New Zealand and other strains of mice.


Impaired gastric secretion in rats treated with 5-azacytidine.


The cytopathology and development of a human polyoma virus (B.K.).


Morphology of SMON virus.

Morphology of SMON virus.


Muscle in Lafora disease.

Muscle in Lafora disease.


Immunoglobulins of human dental plaque.

Immunoglobulins of human dental plaque.


Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol. Tetrahymanol biosynthesis by the protozoan Tetrahymena pyriformis was progressively inhibited by the inclusion of cholesterol in the growth medium. Studies with labelled precursors of tetrahymanol have established that there are two major sites of inhibition in whole cells. The inhibition at the first site, between acetate and mevalonate, occurred rapidly after addition of cholesterol. The activity of 3-hydroxy-3-methylglutaryl-CoA reductase (EC 1.1.1.34), a predominantly cytosolic enzyme in this organism, was not inhibited in cholesterol-grown cells nor by addition of cholesterol directly to the assay medium. The second major site of inhibition in whole cells is between mevalonate and squalene and this is accompanied by inhibition of the enzyme that converts farnesyl-pyrophosphate into squalene (squalene synthetase). Squalene cyclase is partially inhibited. The conversion of mevalonate into tetrahymanol in vitro was not inhibited by the addition of cholesterol to the assay medium. Tetrahymanol added to the culture medium is taken up by the cells but does not inhibit endogenous biosynthesis. It is suggested that cholesterol inhibits the later stages of tetrahymanol biosynthesis by causing a change in membrane structure and function which alters the activity of membrane-bound enzymes.


Damage of rat liver deoxyribonucleic acid by bleomycin.


Uroporphyrin formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug-metabolizing activity.


Electron microscopic study of 'Rushton' hyaline bodies in cyst linings.


Perineal retropubic prostatectomy.

Perineal retropubic prostatectomy.


Macrophage electrophoretic mobility (MEM) test in cancer: a critical evaluation.


Abnormal cells in the peripheral blood of patients with Hodgkin's disease. II. Ultrastructural studies.


Abnormal cells in ther peripheral blood of patients with Hodgkin's disease. I Observation with light microscopy.


Organization and use of multi-disciplinary teaching laboratories at the new medical school, Nottingham.


Radioimmunoassay of alpha-fetoprotein. V. Influence of age on the physiological serum alpha-fetoprotein level in man and in rat.


Immunodiffusion analysis of mouse leukemia antigens.


Detection of common antigenic properties of the pollen of various species of ragweed by passive sensitization of strips of nomkey ileum.


Editorial: Health progress in the Americas.


Selective reaction of effector lymphocytes of transplantation immunity to private specificities of the H-2K and H-2D loci.


Partial thyroidectomy for thyrotoxicosis.


A trial of 1-(2-chlorethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea in the treatment of patients with advanced gastro-intestinal cancer.


Editorial: Drug targets in cancer chemotherapy.


Afferents to the septal area of the rat studied with the method of retrograde axonal transport of horseradish peroxidase.


Transport and changes of activity of choline acetyltransferase in the peripheral stump of an interrupted nerve.


Uptake and transport of horseradish peroxidase by cut end of the vagus nerve.


Diurnal variations of serum cortisol and PBI in the thoroughbred horse and effect of physical effort on plasma cortisol concentration.


An improved silver impregnation method for tracing degenerating nerve fibers and their terminals in frozen sections.


Lupus pericarditis.

Lupus pericarditis. This report documents a case of systemic lupus erythematosus in which the major presenting feature was pericarditis and in which the diagnosis was made after pericardiocentesis by the demonstration of typical LE cells in pericardial fluid stained with Wright's stain. Review of the literature indicates that pericarditis in lupus is more common than is generally suspected, and when it is the initial manifestation it is often misdiagnosed as "benign viral pericarditis".Screening for collagen disease should be a part of the work-up of any patient presenting with pericarditis, especially a woman. Occasionally lupus may be present even when the serologic tests have given negative results. Under such circumstances, or when the patient manifests an atypical or prolonged course, a diagnostic pericardiocentesis is in order, provided an effusion can be confirmed on scan. A search for LE cells should be included in the analysis of the aspirated fluid.


A cytochemical and autoradiographic study of oocyte nucleoli in Limnaea stagnalis L.


New chemotherapeutic agents--bleomycin and adriamycin.


An investigation of ageing in human costal cartilage.


Vital staining of specific monoamine-containing cells in the leech nervous system.


Correlation between microtubular number and transport activity of hypothalamo-neurohypophyseal secretory neurons.


The ultrastructural localization of fibrinogen at the erythrocyte surface and in the capillary endothelium.


On the structure of the human archicortex. I. The cornu ammonis. A Golgi and pigmentarchitectonic study.


A quantitative identification of three muscle fiber types in the body muscles of Lampetra fluviatilis, and their relation to blood capillaries.


Ultrastructure of the neurosecretory system of the Colorado potato beetle, Leptinotarsa decemlineata (Say). I. Characterization of the protocerebral neurosecretory cells.


Ultrastructure of the neurosecretory system of the Colorado potato beetle, Leptinotarsa decemlineata (Say). II. Pathways of axonal secretion transport and innervation of neurosecretory cells.


Distribution and properties of gastrin cells in the gastrointestinal tract of chicken.


Studies on central projections of the pineal nerve tract in rainbow trout, Salmo gairdneri Richardson, using cobalt chloride iontophoresis.


Synthesis and intracellular transport of proteins in the exocrine pancreas of the frog (Rana esculenta). I. An ultrastructural and autoradiographic study.


Neurosecretion in the external and internal zone of the median eminence of the cat and dog.


Nematosomes or nucleolus-like bodies in hypothalamic neurons, the subfornical organ and adenohypophysial cells of the rat.


Isolation from BALB/c mouse cells of a structural polypeptide of a third endogenous type C virus.


The messenger-like properties of the poly(A)plus RNA in mammalian mitochondria.


Current policies of radiation therapy of breast cancer.


The perineal shot: demonstration of prostatic size during urography.


Multicentric and multifocal urothelial tumors.


Precommitment in the immune system.

Precommitment in the immune system.


Electron microscope observations of the organisation of chromatin fibers in isolated nuclei of of rat liver.


A simple method to sequentially reveal Q-and C-bands on the same metaphase chromosomes.


Cytological studies on the organization of DNA in giant trophoblast nuclei of the mouse and the rat.


Comparative analysis of the polytene chromosomes of Glossina austeni and Glossina morsitans morsitans.


Albumin catabolism measurement by a double tracer technique in uraemic patients during a single dialytic treatment.


Possible participation of insulin in the control of vascular permeability.


Nephrotoxic and pneumotoxic antibodies and their acute action on lungs. II. Acute pulmonary lesions and lethal effects of these antibodies in rats.


The anatomy and fine structure of the eye in teleost. II. The vascular connections of the lentiform body in Fundulus grandis.


Influence of oral contraceptives on the rat exocrine pancreas. A histologic, histochemical, and electron microscopic study.


DNA-Feulgen value in brain cells of the adult worker honeybee dependent on age.


Are there any nonspecific large molecule-large molecule interactions?


A simple technique for demonstrating heterochromatin in Nigella.


Detection of fungal spore antigens by serologic methods.


Entry of radioactivity from methyl-labeled methionine into mitochondrial and cytoplasmic RNA of cultured hamster cells.


Electrophoretic separation of proteins on cellulose acetate: a technique for the study of prostatic and vesicular contributions in human seminal fluid.


The expression of H-2 and differentiation antigens on mouse spermatozoa.


Effect of simultaneous administration of antibiotics and TEPA on the realization of potential chromosome breaks as translocation in Drosophila melanogaster.


Interactions of lymphoid cells with transplantation antigens bound to immunoadsorbent.


Immunological relatedness among reptilian, avian, and mammalian pituitary luteinizing hormones.


Comparative immunochemical studies of chicken ultimobranchial calcitonin.


A cytological study on the structure of the pituitary gland of Monopterus albus (Zuiew).


An attempt to induce myelofibrosis in rabbits by saponin injections.


Inhibition of fibrinolysis by the human vascular wall related to the presence of smooth muscle cells.


Effect of prolonged ingestion of polychlorinated biphenyls on the rat.


Liver response tests. IX. Cytopathological changes in the enlarged but histologically normal rat liver.


The behavior of ring chromosome 13.

The behavior of ring chromosome 13.


Monosomy for the centromeric and juxtacentromeric region of chromosome 21.


Tentative localization of a Hageman (Factor XII) locus on 7q, probably the 7q35 band.


Malformative syndrome with ring chromosome 13.


1q plus variants in a normal adult population (one with a pericentric inversion).


Partial trisomy 8: trisomy of the distal part of the long arm of chromosome number 8 plus (8q2) in a severely retarded and malformed girl.


A triploid human abortus due to dispermy.


Trisomy 12p due to familial t(12p-,6q plus) translocation.


Labelling of human chromosomes with 3H-AMD.


A familial reciprocal translocation between three chromosomes.


Letter: A comment to the paper: Variations in normal human chromosomes, Humangenetik 22,1--15(1974).


Observations with G bonding of human chromosomes. Reduction of dye concentration in Soerensen buffered solutions  is sufficient for demonstrating G bands.


Marker chromosomes in parents of spontaneous abortuses.


Possible complex translocation t(9;14;13) (q12;pl?;Q31) in mother of a child with 9-p trisomy syndrome.


Surgery-ends and means. The Fifth Annual Borges Memorial Oration (March 1974).


Mitomycin-C therapy in advanced gastrointestinal malignant tumours.


Studies on the therapeutic use of mercurascan (MSC). Part 2: Antiarrhythmogenic and haemodynamic effect of MSC in experimental myocardial ischaemia.


Immunogenicity of spermatozoa.

Immunogenicity of spermatozoa.


Human prostatic adenoma and carcinoma in cell culture: the effects of androgen-free culture medium.


The autoimmune response to male reproductive tissues of rabbits. III. Effects of testosterone and estrogen on cryoimmunogenic and immunochemical expressions of the central accessory glands.


Virion transcriptase activity of influenza virus isolates.


Interconversion of molecular size of the DNA polymerase from Rauscher leukemia virus.


Viral subtypes and cross-protection in hepatitis B virus infections of chimpanzees.


Measurement of mercury vapor concentrations in urban atmospheres.


Clinical significance of increased serum myoinositol levels.


GM polymorphism and leukemia.

GM polymorphism and leukemia.


Effects of protein source, goitrogens and iodine level on performance and thyroid status of pigs.


Serum and pituitary LH concentrations in ewes infused with LH-RH/FSH-RH.


Editorial: The cytology and the cytochemistry of acute leukaemias.


The first born.

The first born.


A gas chromatographic-mass spectrometric study of organic compounds adsorbed on particulate matter from diesel exhaust.


Studies on the nature of non-specific staining in nitro-blue tetrazolium detection of dehydrogenases in poly acrylamide gel electrophoresis ("nothing dehydrogenase").


A simple method for the clinical determination of the mitotic activity of the human prostate in vitro. Patients with a hyperplastic prostate were studied for the epithelial mitotic activity of adenomatous tissue by the (3)H-thymidine labelling method. A simple method in vitro was improved for biopsy samples. The mitotic activities obtained in vitro were compared with those obtained in vivo. The results show that the mitotic activity is not affected by the short incubation of the samples in Tyrode's balanced salt solution.


Proceedings: A simplified approach to metabolic bone disease.


A simple and rapid method for the differentiation of the members of the genus Klebsiella.


Proceedings: Granulomatous orchitis due to histoplasma capsulatum masquerading as sperm granuloma.


Persistence of chlorpyrifos-methyl in corn silage and effects of feeding dairy cows the treated silage.


Foods and nutrition in a Black Studies program.


Ultrastructural study of membrane-bound enzymes in thymocytes.


A more sensitive and specific histochemical peroxidase stain for the localization of cellular antigen by the enzyme-antibody conjugate method.


Problems of specificity in the use of a strontium capture technique for the cytochemical localization of ouabain-sensitive, potassium-dependent phosphatase in mammalian renal tubules.


A morphological study of the epithalamus and the thalamus of Xenopus laevis.


Relations between some structural parameters of types and forms of neurons effecting different kinds of switches in the neocortex.


The comparative anatomy of the telencephalon of the hagfish, Myxine glutinosa.


Pain and its management.

Pain and its management.


Subcortical projections of the cingulate gyrus in cat.


Tropical canine pancytopenia: Clinical, hematologic, and serologic response of dogs to Ehrlichia canis infection, tetracycline therapy, and challenge inoculation.


Multiple myeloma in Iowa.

Multiple myeloma in Iowa.


Fetomaternal transfusion: a case report.


Letter: Lamellated bodies in the adepidermal space of the frog tadpole skin.


Binding of thyroid hormone in rabbit serum: definition of a prealbumin and effects of strain variation on binding.


Function of the anuran conus arteriosus.


Histological studies of skin carrying bite marks.


Study on the parafollicular cells in the thyroid gland of hamsters by lead hematoxylin staining technics.


Preliminary studies on the control of Japanese encephalitis vectors in Taiwan by chemical means.


Radioimmunoassay of the group-specific antigen in detection of avian leukosis virus infection.


Conservation of weight with the mentally retarded.


Spectrophotometry of cerebrospinal fluid in subacute and chronic subdural haematomas. Spectrophotometric examinations were performed on cerebrospinal and subdural fluids in subacute (five patients) and chronic (20 patients) subdural haematomas, with special reference to the diagnostic aid of CSF spectrophotometry. Spectrophotometric xanthochromia of haemorrhagic origin was found in all CSFs examined, while definite visible xanthochromia was observed in only 28% and the CSF was judged as colourless in 52% of those cases. Characteristic bleeding patterns were found spectrophotometrically in all the 20 CSFs examined within 24 hours after lumbar puncture, haematoma patterns being detected in 90-95% of the cases. In many cases the electrophoretically separated protein fractions of CSF and subdural fluids were spectrophotometrically examined. In conclusion, CSF spectrophotometry is a simple, fast, and extremely sensitive method, which in our opinion should be used routinely in the diagnosis of suspected subdural haematomas, if lumbar puncture is not contraindicated.


Protein pattern or cerebrospinal fluid in spasmodic torticollis. The protein patterns found on isoelectric focusing and quantitative paper electrophoresis of cerebrospinal fluid were studied in three patients with spasmodic torticollis. Very alkaline end fractions were found on isoelectric focusing in the CSF-gammaglobulin region in each case. Alkaline end fractions in the CSF-gammaglobulin region with similar or same isoelectric points have also been observed in other extrapyramidal disorders, particularly Huntington's chorea, and in other neurological diseases, especially in multiple sclerosis. It has to be shown if these alkalline end fractions consist of the same or different compounds, conceivable constituents being mentioned. Examination of the CSF-protein pattern might help to distinguish organic from hysterical torticollis.


A study of the distribution of mitochondria in some oxidative muscle fibres of the pig.


Clinical studies of multiple sclerosis in Japan. Multiple sclerosis starting with retrobulbar neuritis.


Central neuroblastoma induced by transplacental administration of methylnitrosourea in Wistar-R rats. An electron microscopic study.


Current approaches in the treatment of malignant gliomas of the brain.


The patient that mattered.

The patient that mattered.


The berry aneurysm patient: the surgical management--from hemorrhage to follow-up.


Possible antagonism of amphetamine by decongestant-antihistamine compounds.


The effect of lithium on thyroid functioning: a controlled study.


Chromocentres in polymorphs as interphase markers for chromosomes having increased constitutive heterochromatin.


Trisomy 21 mosaicism in a woman with two children with trisomy 21 Down's syndrome.


Three generations and seven family members with a t(21q22q) chromosome.


Familial mental retardation in a family with an inherited chromosome rearrangement.


Evaluation of multimedia self-teaching programs for medical students taking community preceptorships.


Karyotype 45,XX,-21/46,XX,21q-in an infant with symptoms of G-deletion syndrome I.


Preparation and characterization of plasma membrane of cardiac tissue.


Calcium-movement controlling cardiac contractility II. Analog computation of cardiac excitation-contraction coupling on the basis of calcium kinetics in a multi-compartment model.


Nitroblue tetrazolium (NBT)-dye test and the myeloperoxidase reaction of human leukocytes.


Quantitative and qualitative analyses of the antibody response of adult mice tolerized with deaggregated bovine gamma-globulin. I. At the serum antibody level.


Quantitative and qualitative analyses of the antibody response of adult mice tolerized with deaggregated bovine gamma-globulin. II. At the cellular level.


Prolonged intra-aortic infusion therapy with anti-tumor agents for advanced cancer of the stomach, colon and rectum.


The discoveries of vitamin K and dicumarol and their impact on our concepts of blood coagulation.


Letter: death and coronary attacks after giving up cigarette smoking.


Portal hypertension with varices in unusual sites.


Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease.


Infusion of angiotensin-II analogue in two patients with unilateral renovascular hypertension.


Amoebic infection of the eye.

Amoebic infection of the eye.


Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis.


DNA microdensitometry as a measure of cycling-non-cycling activity in aged human diploid cells in culture.


Inadequate antibody response to hBAg or suppressor T-cell defect in development of active chronic hepatitis.


Editorial: Autoimmune diabetes mellitus.


Decreased glucagon activity: A mechanism for genetic and acquired endogenous hyperlipaemia.


Editorial: Kuru, Creutzfeldt-Jakob, and scrapie.


Editorial: Oral bacterial vaccine and colds.


Editorial: Too good to die.

Editorial: Too good to die.


Editorial: Tryptophan and serotonin in Down syndrome.


Quality and quantity in chemical pathology.


Diphtheria in the Manchester area 1967-1971.


Letter: Reduction of sudden Deaths after myocardial infarction.


Letter: Death and coronary attacks after giving up cigarette smoking.


Letter: Treatment of malignant melanoma.


Letter: Effect of surgery on lymphocytotoxicity against tumour cells.


Letter: Yersinia enterocolitica infection and thyroid disorders.


Letter: Doctors, money, and N. H. S.

Letter: Doctors, money, and N. H. S.


Letter: Social workers in the primary-care team.


Letter: Iron deficiency and infection.

Letter: Iron deficiency and infection.


Letter: Priapism during regular dialysis.


Letter: Errors of lead analyses: dependability of laboratories and clinicians.


Letter: Lupus erythematosus, D. N. A. antibodies, and suppression of erythropoiesis.


Letter: Aetiology of systemic lupus erythematosus.


Letter: the specialty of infectious disease.


Letter: are rauwolfia alkaloids carcinogenic?


Letter: Rauwolfia derivatives and breast cancer.


Letter: Control of respirator-associated infections.


Letter: Immunosuppressive treatment of rapidly progressive glomerulonephritis.


Letter: Preoperative hydration in chronic renal failure.


Letter: Dispersal of Staphylococcus aureus.


Letter: HL-AS and the immune response to gluten.


Letter: Endoscopic liver biopsy.

Letter: Endoscopic liver biopsy.


Letter: Epidemic of aortic aneurysm?

Letter: Epidemic of aortic aneurysm?


Letter: Muscle biopsy in Crohn's disease.


Letter: N. B. T. test in pulmonary embolism and bacterial pneumonia.


Letter: Medicine in the Open University.


Letter: Multiple sclerosis: vesicles at vaccination scar.


Letter: Natural history of hypertension.


Letter: Withdrawal of antihypertensive therapy.


Letter: Zollinger-Ellison syndrome in Negroes.


Letter: Transmission of carcinoembryonic antigen by transfused blood.


Letter: An antigen associated with pregnancy.


Letter: Double deletion of X chromosome.


Letter: Mitochondria, autoimmunity, and oncogenesis.


Letter: Placental transmission of L. A. T. S. protector.


Letter: Ageing, T lymphocytes, and Down's syndrome.


Letter: A new molecular defect in phenylketonuria.


Letter: Herpes-simplex virus (type 1) transmitted to a neonate.


Maurice Ernest Noel Smith.

Maurice Ernest Noel Smith.


Evaluation of an audiovisual carrel-tutorial course in clinical medicine.


Inhibitors of immune reactions.

Inhibitors of immune reactions.


The application of the negative staining technique to the study of membranes.


Myelin basic proteins.

Myelin basic proteins.


Scanning electron microscope methods for the study of membranes.


Use of antibodies of localization of components on membranes.


Methods for the study of chloroplast membranes of wild-type and mutant strains of Chlamydomonas reinhardi.


Isolation of oxyntic cells.

Isolation of oxyntic cells.


Basic methodology for cell culture--cell transformation.


The isolation of Chlamydia subgroup A (Chlamydia trachomatis) in irradiated McCoy cells.


Enzyme treatment of unfixed cell cultures as a means of determining different specificities of immunoglobulin-M in multiple sclerosis and measles.


Immunological study of the agent responsible for subacute sclerosing panencephalitis and biochemical characterization of measles antibody in subacute scelerosing panencephalitis.


The gamma particle. A study of cell-organelle interactions in the development of the water mold Blastocladiella emersonii.


The need for a clinical teacher.

The need for a clinical teacher.


Binding of exogenous noradrenaline by the proteins of dog plasma.


Search for oncogenicity of type C particles released from mammalian cell lines transformed by avian Oncornaviruses.


Detection of oncornavirus-like particles in human cell lines derived from tumours of hemopoietic tissue.


Liver growth and mixed-function oxidase activity: dose-dependent stimulatory and inhibitory effects of alpha-hexachlorocyclohexane.


Somatic cell hybrids between mouse cells and avian sarcoma virus transformed hamster cells.


Correlation between the intensity of in vitro migration of peritoneal exudate cells and the quantity of nonadherent cells.


Reversible hypogammaglobulinaemia after diphenylhydantoin and hydroxyzine therapy.


Measuring the progress of a health service.


Letter: Stilboestrol.

Letter: Stilboestrol.


Carcinoma of the bowel.

Carcinoma of the bowel.


Organochlorine insecticide residues in carpeting.


Nursing care study: modified Wertheim's hysterectomy.


Microscopy of surgical specimens.

Microscopy of surgical specimens.


Modern visual aids.

Modern visual aids.


Nursing care study; Acholuric jaundice.

Nursing care study; Acholuric jaundice.


Nursing care study; Suprapubic prostatectomy.


Hypogammaglobulinaemia with Whipple's disease.


Episodic weakness in thyrotoxicosis.

Episodic weakness in thyrotoxicosis.


Immune responses of inbred guinea pigs to the random terpolymers poly (Glu57Lys38Tyr5) and poly (Glu51Lys34Tyr15).


Consecutive activation of a type C RNA and polyoma virus from tumors induced by polyoma virus-transformed rat cells.


Histamine release from human leucocytes by concanavalin A and other mitogens.


Kallikrein inhibitory capacity of alpha2-macroglobulin subunits.


A reduced silver stain for normal axons in the central nervous system.


Impairment of the freedom to change with the acquisition of the symbolic process.


Little Black Sambo.

Little Black Sambo.


Psychotherapeutic assistance to a blind boy with limited intelligence.


Death education and its effect on the death anxiety level of nurses.


Public health aspects of air pollution from diesel vehicles.


Elastic fibres and reticulin of mammalian muscle spindles and their functional significance.


Comparison of self-rating and quantity-frequency measures of drinking.


Begging and social deviance on skid row.


Factor analysis of gross and fine motor ability in developmentally disabled children.


Erythrophagocytosis by pathological erythroblasts in the Di Guglielmo syndrome. A study of 18 cases.


Immunoglobulin-containing intranuclear inclusions in plasma cells in a case of IgG myeloma.


Comparison of tuberculosis case-finding in a high prevalence area.


[Why don,t we use more audio-visual aids?].


Possible mechanism for the fibrinolytic effect of certain bis-tetrahydroisquinolines: evidence for histamine release.


Non-extractable lipids in the adipose tissues of horses and ponies affected with generalized steatitis. When adipose tissues of horses and ponies affected with generalized steatitis were extracted by acetone, methanol and chloroform, non-extractable lipids were found to be present, which had become insoluble as a result of peroxidation and polymerization and had acquired autofluorescent characteristics. The origin of these lipids varies. Peroxidation occurs in three different lipid compartments, namely in the cytoplasm of the necrotized adipose cells, in the macrophagess and in the fat globules present in stroma.


Chlorphentermine-induced lipidosislike ultrastructural alterations in lungs and adrenal glands of several species.


Residual effects of short-term, low-level exposure of nonhuman primates to polychlorinated biphenyls.


Burn shock.

Burn shock.


Improved weight gains in pigs following treatment for sarcoptic mange.


Intraneuritic corpora amylacea. Demonstration in orbital cortex of elderly subjects by means of early postmortem brain sampling and electron microscopy.


A histological study of the adenohypophysis of the rat. 1. Evaluation of some specific staining methods.


The effect of ageing on enzyme histochemical vital reactions.


Contribution to the assessment of the pre-operative condition of the nose in patients with palatoschisis.


Free-skin transplantation using the "sito" graft in the treatment of faulty stumps of the lower limb.


Purpura fulminans.

Purpura fulminans.


Formation of vagina (colpopoiesis) from peritoneum of Douglas pouch.


Reconstructive surgery for faulty short amputation stumps of foot.


Fractures in rhinoplasty.

Fractures in rhinoplasty.


Tissue bank of the University Hospital in Hradec Králové (conception, work, future).


Complicated reconstruction after mutilating operation of the lip in bilateral cleft of the primary and secondary palate.


Lipid peroxidation in erythrocytes. Supravital staining of peroxidised cells by crystal violet.


Secondary anemia (XV) and reticuloendothelial uptake in cancer.


Origin of the marker chromosomes in an established hypotriploid glioma cell line studies with G-band technique.


Iatrogenic Crooke's changes in human pituitary gland with special reference to the correlation of cortical hormones applied.


Plasma protein metabolism.

Plasma protein metabolism.


Analysis of variance of the Papanicolaou staining reaction.


Letter: Cytology of epithelioid sarcoma.


Porcine salmonellosis: a counterpart to the generalized Shwartzman reaction.


Lobular carcinoma in situ. A histological study of 52 cases.


Effect of ricin immunization on the qualitative compositions of plasma proteins.


Malignant melanoma of the vagina. A case diagnosed cytologically.


Hyalinosis as the cause of massive cerebral hemorrhage.


Early results of intraarterial application of bleomycin, methotrexate and proresid in locally advanced head and neck tumors.


Pathophysiology and epidemiology of acute viral infections of the nervous system.


Immunodiagnosis and immunization in bacterial meningitis.


Acid secretion and mobilization of gastric mucosal histamine on combined cholinergic and pentagastrin stimulation.


Landmarks in malaria research (a review).


A study of striae observed in the cornea from contact lens wear.


The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Administration of 0.5 mg bleomycin to mice twice weekly for 4 weeks induced pulmonary fibrosis. The initial site of injury was the intima of pulmonary arteries and veins where endothelial cells became edematous and were separated from the underlying basement membrane by large blebs. These lesions occurred after 2 weeks and were associated with infiltration of perivascular spaces by lymphocytes and plasma cells. Capillary endothelial blebbing and interstitial edema were observed after 4 weeks, when multifocal necrosis of type 1 alveolar epithelial cells was accompanied by fibrinous exudation into the alveoli. The process of repair was characterized by proliferation and metaplasia of type 2 epithelial cells, fibroblastic organization of alveolar fibrin and fibrosis of the interstitium within 8 to 12 weeks. The consistent induction of changes similar to those of diffuse pulmonary fibrosis or fibrosing alveolitis in man suggests that bleomycin-induced injury may provide a suitable model for the investigation of this ill-defined group of diseases.


An improved method for the colorimetric assay of thiacetazone in pharmaceutical preparations.


Pathology of the pigment epithelium and retina in rabbits poisoned with lead. Multifocal lesions of the retinal pigment epithelium were observed in rabbits fed a diet contaning 0.5% lead subacetate for periods of up to 2 years. Groups of pigment epithelial cells became congested with a lipofuscin pigment which was apparently derived from phagosomes of rod outer segments. Lipofuscin granules displaced melanin granules from the apical surface of the retinal pigment epithelial cells and resulted in conspicuous brown pigmentation of these cells in albino animals. Migration of macrophages and pigment epithelial cells into the subretinal space was common in affected areas. This pathology was not observed in the pigment epithelium of the ora serrata, or ciliary body. At the latest time periods, the abnormal lipofuscin pigmentation subsided, and degeneration of photoreceptors occurred. The pathogenesis of the lesions is discussed.


Fatty acids of the fat body of Pieris brassicae L. during metamorphosis; effect of a low concentration of a chlorinated insecticide.


In-vitro culture of Kaposi's disease cells.


Bovine babesiasis: computer simulation of Babesia argentina parasite rates in Bos taurus cattle.


The use of BCG as a source of acid and alcohol fast bacilli for staining purposes.


Tubular complex of small lymphocytes in lymphatic tissues of the mouse.


Role of easily released substances (ERS) from bacteria into physiologic solutions in natural immunity. V. Antigenic relation of bacterial ERS and human gamma-globulins of the Gm and InV systems.


Ultrastructural observations on the keratohyalin granules of the rat oral epithelium.


The incidence of epithelium in periapical granulomas and the mechanism of cavitation in apical dental cysts in man.


Distribution within the cochlea of dihydrostreptomycin injected into the circulation. An autoradiographic and electron microscopic study.


Immediate hypersensitivity responses in the marsupial Setonix brachyurus (the quokka). Characterization of the homocytotropic antibody.


A programmed individual study method for teaching veterinary radiology: a pilot study.


The effect of burimamide, an H-2 receptor antagonist, upon the general and coronary haemodynamics of intact dogs and upon histamine release by Tween 20.


Multiple family therapy.

Multiple family therapy.


Structure of mammalian chromosomes.

Structure of mammalian chromosomes.


Genetic aspects of spermatoza.

Genetic aspects of spermatoza.


Quantitation of heterogeneous human heterochromatin: microdensitometric analysis of C-and G-bands.


Chemical and structural analysis of mammalian spermatozoa.


A new method for staining for peptidase on polyacrylamide gels.


Intra-axonal transport in noradrenergic neurons in the sympathetic nervous system.


Ionophore-mediated coupling between ion fluxes and amino acid absorption in mouse ascites-tumour cells. Restoration of the physiological gradients of methionine by valinomycin in the absence of adenosine triphosphate. 1. Preparations of mouse ascites-tumour cells depleted of ATP and Na(+) ions accumulated l-methionine, in the presence of cyanide and deoxyglucose, from a 1mm solution containing 80mequiv. of Na(+)/l and about 5mequiv. of K(+)/l. Valinomycin increased, from about 4 to 16, the maximum value of the ratio of the cellular to extracellular concentrations of methionine formed under these conditions without markedly affecting the distributions of Na(+) and of K(+). Similar observations were made with 2-aminoisobutyrate, glycine and l-leucine. Increasing the extracellular concentration of K(+) progressively decreased the accumulation of methionine in the presence of valinomycin. Over the physiological range of ionic gradients, the system behaved as though the absorption of methionine with Na(+) was closely coupled to the electrogenic efflux of K(+) through the ionophore. The process was insensitive to ouabain and so the sodium pump was probably not involved. 2. The amount of methionine accumulated during energy metabolism was similar to the optimal accumulation in the presence of valinomycin when ATP was lacking. It was also similarly affected by increasing the methionine concentration. 3. A mixture of nigericin and tetrachlorosalicylanilide mimicked the action of valinomycin. The anilide derivative inhibited the absorption of 2-aminoisobutyrate in the presence of valinomycin, but not in its absence. 4. Gramicidin inhibited methionine absorption and caused the preparations to absorb Na(+) and lose K(+). 5. The observations appear to verify the principle underlying the gradient hypothesis by showing that the tumour cells can efficiently couple the electrochemical gradient of Na(+) to the amino acid gradient.


Clinical experience with euthroid: a new drug for thyroid replacement therapy.


A follow-up study of nineteen alcoholic patients treated by means of tetraethyl-thiuram disulfide (antabuse) implants.


Comparative effect of imolamine, lidocaine and disopyramide on experimental rhythm disorders and auriculoventricular conduction.


The colony forming efficiency of single cells and cell aggregates from a spontaneous mouse mammary tumour using the lung colony assay. Single cell suspensions of spontaneous C3H mammary tumours did not produce colonies in the lungs of syngeneic mice after intravenous injection whereas cell aggregates obtained from similar tumours did. The number of colonies formed after the injection of aggregates was related to aggregate size and was proportional to the number injected.Single cells grew in an intramuscular site and in vitro and it was also found that if spontaneous tumours were passaged in vivo a few times single cells would grow in the lung.


A spontaneous glomerular lesion in the Syrian hamster (Mesocricetus auratus).


The autonomic control of colonic mucin secretion in the mouse.


Incidence of carcinoma of stomach and tumour type.


The molecular organization of the very rapidly renaturing DNA sequences in Drosophila melanogaster: further evidence for a class of non-satellite simple sequence DNA.


Autonomic neuroreceptor mechanisms in brain vessels.


Giemsa banding of the chromosomes of the domestic sheep (Ovis aries).


The organic-inorganic relationships in bone matrix undergoing osteoclastic resorption.


Histochemical studies on calcified tissues. II. Amino acid histochemistry of developing dentine and bone.


Chromosome structure in Chilocorus (Coleoptera: Coccinellidae). I. Fluorescent and Giemsa banding patterns.


The ultrastructure of the skin of Tilapia mossambica (Peters).


Possible mechanisms determining synapse formation in developing skeletal muscles of the chick.


Substrate-histochemical investigations and ultrahistochemical demonstrations of acid phosphatase in larval and prepupal salivary glands of Drosophila melanogaster.


A preschool screening program on central Vancouver Island: a two-year follow-up.


On pigment-loaded stellate cells within layer II and III of the human isocortex.


Phase I study of twice weekly 5-azacytidine (NSC-102816).


Ultrastructural and cytochemical studies of perifollicular mesenchyme in the thyroid gland of the golden hamster.


Public health under Napoleon: The Conseil de Salubrité de Paris, 1802-1815.


William Bullein and the "lively fashions" in Tudor medical literature.


Friedrich Hoffman and some medical aspects of witchcraft.


Bellini's concept of catarrh: an examination of a seventeenth-century iatromechanical viewpoint.


Methyl prednisolone in the treatment of renal transplant rejection.


Invluence of oral contraceptives on circulating immune response. II. Effect of progestogenic and estrogenic components. Female mice were treated with chlormadinone acetate (.25 mcg or 6.25 mcg), megestraol acetate (.25 mcg or 6.25 mcg), ethynodiol diacetate (.5 mcg or 12.5 mcg), norgestrel (.25 mcg or 6.25 mcg) or norethynodrel (2.5 mcg or 62.5 mcg) and  studied to determine what effect these progestagens had on circulating tetanus antibody titers.  None of the progesterones affected the immune response to tetanus toxoid.  Mice given ethinyl estradiol or mestranol had enhanced circulating antibody titers.  It is conlcuded that combination oral contraceptives act to diminish antibody response as a result of the combined potency of the estrogen and progesterone components.


Neonatal immunology and related protective mechanisms.


Differential Giemsa staining of sister chromatids and the study of chromatid exchanges without autoradiography.


Giemsa technique for the detection of sister chromatid exchanges.


Cytological differentiation of constitutive heterochromatin.


X and Y chromosomes of Aedes aegypti (L.) distinguished by Giemsa C-banding.


Comparative study of human chromosome replication in primary cultures of embryonic fibroblasts and in cultures of peripheral blood leucocytes . I. Chromosome replication at the beginning and termianation of the S PERIOD.


Banding patterns on lampbrush chromosomes of Triturua marmoratus (Amphibia Urodela) by the Giemsa stain.


Studies on lysostaphin. Serological cross-reactions between three isolated enzymes.


Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits.


PG fertility control research--maps and directory.


World fertility trends, 1974.

World fertility trends, 1974.


Colon cancer: a disease of fibre depletion or of dietary excess?


The X chromosomes of mammals: karylogical homology as revealed by banding techniques. A comparison of the Giemsa-banding patterns of the X chromosomes in various mammalian species including man indicates that two major bands (A and B), which are resistant to trypsin and urea-treatments, are always present irrespective of the gross morphology of the X chromosomes. This is true in all mammalian species with the "original or standard type" X chromosomes (5-6% of the haploid genome) thus far analyzed. In the unusually large-sized X chromosomes the extra chromosomal material may be due either to the addition of genetically inert constitutive heterochromatin or to an X-autosome translocation. In these X chromosomes two major bands are present in the actual X-chromosome segment. Our data on C and G band patterns also support Ohno's hypothesis that the mammalian X chromosome is extremely conservative in its genetic content, in spite of its cytogenetic variability.


Life cycle of RNA oncogenic viruses.

Life cycle of RNA oncogenic viruses.


RNA tumor viruses and human leukemias.

RNA tumor viruses and human leukemias.


RNA tumor viruses and human lymphomas.

RNA tumor viruses and human lymphomas.


Biochemical evidence for the presence of RNA tumor viruses in human leukemic plasma.


Relatedness of RNA and reverse transcriptase from human acute myelogenous leukemia cells and from RNA tumor viruses.


The molecular basis of gene expression.

The molecular basis of gene expression.


Glucocorticosteroids and RNA tumor viruses.


The relevance of RNA-directed DNA polymerase activity to human neoplasia.


Reverse transcriptase of an oncornavirus-like particle derived from human HeLa cells.


On the origin of human acute myeloblastic leukemia: virus-"hot spot" hypothesis.


Cytology and cytochemistry of the leukemia cell.


DNA-dependent DNA and RNA polymerases and tRNA-methyl-transferases in human leukemia and differentiating Friend virus leukemia cells.


Human leukemia--an overview.

Human leukemia--an overview.


Hemopoietic stem cells and leukemia.

Hemopoietic stem cells and leukemia.


Differentiation and transformation of hematopoietic cells in culture.


A presumptive tetrasomy for the short arm of chromosome 9.


Mosaic-trisomy and pericentric inversion of chromosome 9 in a malformed boy.


Participation of D-group chromosomes in satelite associations.


Partial trisomy 4q and partial monosomy 18q as a consequence of a paternal balanced translocation t(4qminus; 18qplus).


Social science and health policy in preindustrial society.


Notes on the psychical roots of religion, with particular reference to the development of western Christianity.


A discussion of the paper by Ernesto M. La Porta on "Agression, error and truth".


Aggression, error and truth.

Aggression, error and truth.


The Alaskan Athabaskan potlatch ceremony: an ethnopsychoanalytic study.


Diabetes associated with prostatic hypertophy and its managemnet in transvesical prostatectomy.


Characterization of the major viral polypeptide in cells transformed by wild-type and temperature-sensitive murine sarcoma virus.


Elimination of wheat and rye chromosomes in a strain of octoploid triticale as revealed by giemsa banding technique.


Absence of longitudinal differentiation of dinoflagellate (Prorocentrum micans) chromosomes.


Cytogenetic investigations on a Ehrlich ascites tumor, and four sublines resistant to daunomycin, adriamycin, vincristine and vinblastine.


The influence of salt on the staining of tissue sections with basic dyes: an investigation into the general applicability of the critical electrolyte concentration theory.


The mechanism of false-positive lipid histochemical reactions of glutaraldehyde-fixed rat adrenal medulla.


The mechanism of the ferric ferricyanide reduction reaction.


Anisotropy and isoelectrical point determinations on collagen bundles of the rat periodontal fibers.


Histochemical observations with the light and the electron microscope on the mucosubstances of the normal mouse gallbladder epithelial cells.


Selective proteolytic sensitivity of sulfate-collagen and basement membranes.


Proceedings: On neutral red staining of APUD cells.


Proceedings: The distribution of chromaffin-positive (CH plus) and small intensely fluorescent (SIF) cells in rat sympathetic ganglia of different ages.


Alpha-1 antitrypsin deficiency in pulmonary diseases.


Electron-microscope observations on the organization of the nucleus in chicken erythrocytes and a superunit thread hypothesis for chromosome structure.


Visualization of charged groups on the surface of rat liver nuclei.


Structure of layer IV in the somatosensory neocortex of the rat: description and comparison with the mouse.


Fast axoplasmic transport in nonmyelinated mammalian nerve fibers shown by electron microscopic radioautography.


Indices for measurement of soft accumulations in clinical studies of oral hygiene and periodontal disease.


Electrical responses of double cones in the turtle retina. 1. Responses to monochromatic flashes were recorded intracellularly from double cones in the retina of the turtle, Pseudemys scripta elegans. Double cones have been identified by intracellular marking with Procion Yellow dye.2. The direct light response of a double cone is a hyperpolarization graded with the intensity of a flash and similar to the response of single cones.3. When flashes were dim, responses were proportional to light intensity but varied in time course as a function of wave-length. They reached peak in about 120 msec for deep red stimuli and about 143 msec for green stimuli.4. When applied over red backgrounds, responses to red flashes became smaller, faster and frequently diphasic, but responses to green remained similar to those recorded from darkness. Green backgrounds made responses to all colours small and fast.5. Linear spectral sensitivity curves have peaks corresponding to the peak sensitivities of single red-sensitive and green-sensitive cones. Red and green backgrounds suppressed red and green sensitivity respectively.6. Large fields of illumination evoked composite responses which included the direct light response, its enhancement from illumination of nearby receptors and the depolarizing effect of luminosity horizontal cell impingement. In the green-sensitive element the depolarizing effect was larger for red than for green flashes, and stimulation with red annuli evoked net depolarizing responses.7. It is concluded that the responses of double cones may be explained by coupling of the responses from red-sensitive and green-sensitive elements each of which has properties otherwise similar to single red-sensitive and green-sensitive cones.


Protein and glucose-induced changes in sodium transport across the pig small intestine. 1. The effect of glucose and of bovine gamma-globulin on short-circuit current and sodium transport was measured using new-born pig ileum before and after suckling.2. Glucose increased the short-circuit current with an apparent K(m) of 1.9 and 19.5 mM for new-born unsuckled and suckled intestines respectively. The V(max) was about 80 muA cm(-2) in each case.3. Bovine gamma-globulin applied to new-born pig ileum caused a 20% increase in sodium chloride influx without change of short-circuit current. The tissue conductance was also greater in the presence of globulin. These effects were not seen in ileum taken from suckled pigs.4. p-Chloromercuriphenyl sulphonic acid (PCMPS) inhibited the globulin induced increase in sodium influx in new-born pig ileum without changing the measured short-circuit current. 0.1 mM-PCMPS also changed the characteristics of the glucose-dependent increase in short-circuit current, so that this response came to resemble that seen in ileum taken from suckled pigs. Dithioerythritol reversed this effect of PCMPS.5. The suckling-dependent difference in results is explained in terms of a change in microvillar function taking place as a consequence of long-term pinocytosis in vivo. The ability of PCMPS to simulate some of these changes suggests that sulphydryl groups might be important regulators of microvillar membrane stability.


The release of histamine during gastric acid secretion in conscious rats. 1. Conscious gastric-cannulated rats were given [(3)H]histidine and aminoguanidine by dosage procedures intended to build up fast-turnover and slow-turnover pools of tissue [(3)H]histamine. Acid secretion was stimulated by I.V. infusion of pentagastrin, and the [(3)H]histamine content of gastric juice and excretion in urine were determined at 30 min intervals.2. The amount of [(3)H]histamine in gastric juice derived from either a slow-turnover or fast-turnover pool was very low in unstimulated animals, and was not altered during pentagastrin-stimulated acid secretion.3. From a slow-turnover pool pentagastrin caused increased urinary excretion of [(3)H]histamine. This was abolished by gastrectomy, so that the [(3)H]histamine liberated by pentagastrin from this pool appears to have been derived from the stomach. Evidence was not found for the existence of a slow-turnover histamine pool in the glandular mucosa of the stomach, and the source within the stomach of this pentagastrin-liberated histamine is thus uncertain.4. From a fast-turnover pool pentagastrin did not cause an increased urinary excretion of [(3)H]histamine. The amount of [(3)H]histamine excreted by gastrectomized rats was not different from that produced by gastric-cannulated animals. This suggests that a high proportion of urinary histamine derived from a fast-turnover pool was non-gastric in origin.5. Differences in the time scale of [(3)H]histamine release and acid secretion were not found. In some experiments the urinary output of [(3)H]histamine was prolonged beyond the end of pentagastrin administration and gastric acid secretion. However, the overall data do not suggest that urinary histamine output and gastric acid secretion take different time courses.


Antigens and antigenic variability of the African trypanosomes.


Differentail nuclear coloration in ciliates.


The ontogenetic development of concentration differences for protein and ions between plasma and cerebrospinal fluid in rabbits and rats. 1. The purpose of this study was to study in rats and rabbits the ontogenetic development of the blood-brain barrier to macromolecules and the ontogenetic development of concentration differences between plasma and cerebrospinal fluid for ions which are known to be transported actively across the choroid plexus and the blood-brain barrier.2. By comparing the development of concentration differences for ions with the development of the blood-brain barrier to macromolecules we wanted to evaluate an eventual relationship between the development of these two functions of the blood-brain barrier.3. The concentration of protein in cerebrospinal fluid and plasma was measured in foetal, juvenile and adult rabbits and in new-born, juvenile and adult rats. The concentration of protein was similar in rabbit foetuses at 23 days of gestational age (term at 31 days) and in new-born rats, and the ratio decreases at approximately the same rate in the two species.4. The high concentration of proteins in cerebrospinal fluid might reflect either a high rate of entry of protein into the brain or a low production rate of cerebrospinal fluid. Injection of Diamox(R) (100 mg/kg) 2 hr before sampling of cerebrospinal fluid did not change the concentration of protein in cerebrospinal fluid in new-born rats whereas it increased the concentration in older rats. This finding suggests that new-born rat produces little (if any) cerebrospinal fluid suggesting that the high concentration of protein in cerebrospinal fluid in new-born rats reflect a low rate of turnover of cerebrospinal fluid.5. The concentration of sodium, potassium, chloride and magnesium in plasma and cisternal cerebrospinal fluid was measured in rabbits of different age, from 23 days of gestation until adulthood, and in rats of different ages from birth until adulthood.6. Concentration differences between plasma and cerebrospinal fluid for these were established in the youngest animals examined, indicating that the active transport mechanisms for these ions were functioning at an age where the concentration of protein in cerebrospinal fluid was very high.7. The maintenance of concentration differences for ions at a time where the concentration of proteins in cerebrospinal fluid is high, is difficult to explain if the high concentration of proteins in cerebrospinal fluid is due to a leakiness of the intercellular junctions between cerebral endothelial cells. However, the findings might be explained either by a low rate of production of cerebrospinal fluid in the youngest animals and/or by a pinocytotic transfer of proteins across the blood-brain barrier in these animals.8. In rats concentration gradients for ions are established at an age (new-borns) with a low or absent bulk formation of cerebrospinal fluid and at an age where the capillaries are still not enveloped by astrocytic foot processes. These facts suggest that the active transport mechanisms for the ions must be located in the cerebral endothelial cells.


A dicentric Robertsonian translocation in a Dexter Cow.


Ultrastructural changes in renal tubules of sheep following experimental infection with Leptospira interrogans serotype pomona.


Sequence of structural changes in cultures of Clostridium tetani grown on a solid medium.


Banding identification of partial trisomy 15 and of 8/21 translocation.


Plasma proteins of the pregnant and normal Rhesus monkey (Macaca mulatta). A two-dimensional electrophoretic study.


Four cases of 9p trisomy resulting from a balanced familial translocation (9:15) (q13;q11). Clinical picture and cytogenetic findings.


Studies on the healing of experimental ulcer in the rat II: influence of anti-inflammatory drugs on the healing of the acetic acid ulcer and the components in gastric tissue.


The interpretation of electrocardiograms in small animals.


Angiotensin and catecholamines of the central nervous system.


Nucleic acids attached to solid matrices.


Effects of fasting on intermediate hepatic metabolism of the rat.


Protein nutrition of Tenbrio molitor L. XVII. Improved amino acid mixture and interaction with dietary carbohydrate.


Vitamin B 2(riboflavin)-sparing activity of ascorbic acid in the larval nutrition of Oryzaephilus mercator Fauvel (Coleoptera).


Metabolic kinetics of the anti-ketotic compound 1,2-propanediol in the rumen.


Conditioning of depressor responses evoked by stimulation of aortic nerve in the rabbit.


Contralateral potentials in the suprasylvian gyrus evoked by pulvinar stimulation.


Metabolic effects following a medium chain triglycerides load in dogs.  V. Influence of the perfusion rate.


Immunoaffinity chromatography of proteins.


Bovine thyroid gangliosides: distribution pattern after differential pelleting.


Proceedings: Ammonia and amino acids in the brain of the rat with chronic hepatic failure.


Proceedings: Intra- and extracranial blood flow during sympathetic nerve stimulation.


Proceedings: Influence of changes in the acid-base balance on cerebral blood flow after an actue hypertensive insult.


Cone and rod ERP in the human eye.

Cone and rod ERP in the human eye.


Proceedings: Bioluminescence of a bathypelagic fish, Argyropelecus hemigymnus Cocco.


Proceedings: Osmolality and myocardial function.


Proceedings: Information content of an RNA genome.


Proceedings: Previously unrecognized interactions among synthetic homopolynucleotides and their complexes revealed by interferon induction studies.


Proceedings: Methylation of yeast aspartic-tRNA by enzymes from cytoplasm, chloroplasts and mictochondria of Phaseolus vulgaris.


Proceedings: Improved synthetic templates for the RNA-instructed RNA polymerase of bacteriophage Q beta.


Proceedings: Effect of polyamines on aminoacylation of tRNA from Phasaeolus vulgaris.


Proceedings: Isolation of acidic coat mutants of the RNA bacteriophage MS2 by use of polyacrylamide gel electrophoresis.


Proceedings: Influence of pressure on the relaxation kinetics of the binding of  ethidium bromide to yeast tRNA.


Proceedings: Isolation and translation of a 33 s mRNA coding for a beef heavy-chain thyroglobulin.


Proceedings: Structure and function studies on ferritin.


Proceedings: Inhibition by Cd2+ of the endogenous respiration of Endomycopsis lipolytica.


Proceedings: Sodium dodecyl sulphate electrophoresis on polyacrylamide gel of functional tryptic fragments of crystalline beta-haemocyanin of Helix pomatia.


Proceedings: Activation of the inactive precursor of collagenase by kallikrein and plasmin.


Proceedings: Influence of pressure on the reduction of horse heart ferricytochrome c with potassium ferrocyanide.


Proceedings: The effect of monoglyceride feeding on serum lipoproteins in the absorptive state in man.


Proceedings: Threshold-dependent phenomena in photomorphogenic processes.


Proceedings: A long-term effect of phytochrome on the induction of chlorophyll synthesis.


Proceedings: Stimulation of cellular transport by cyclic AMP in yeast.


Proceedings: Endogenous lysophospholipids, phosphatide acyl hydrolase activity and fatty acids esterification in liver particles.


Proceedings: Protein phophokinase associated with rabbit skeletal muscle sarcoplasmic vesicles.


Proceedings: Isolation of the A-protein from bacteriophage MS2 and sequence analysis of soluble trypitic peptides.


Proceedings: Functional significance of estrogen-induced protein in rat uterus.


The cell coat in the neuropil of the chick spinal cord during development.


A new staining method for nucleoli.

A new staining method for nucleoli.


A histochemical study of the epidermal keratinization in the skin of a fresh-water teleost Bagarius bagarius (Ham.) (Sisoridae, Pisces).


Fenfluramine-induced ultrastructural alterations in tissues of rats and guinea pigs.


Rational management of thyroid auto-immune disease.


The search for positive goitrogenic agents.


Interrelations of the search for naturally-occurring goitrogens to the treatment of thyrotoxicosis.


Purves symposium: 2. Pituitary morphology in relationship to function. General principles. It was found that the recognition of the character of a pituitary cell depended on its content of granules.  The term "chromophobe" indicated the absence of granules.  In the rat pituitary, total thyroxine deficiency resulted in progressive loss of granules from acidophil cells until they became unrecognizable as such.  Therefore, counting the cell types as acidophils, basophils, and chromophobes had no significance.  However, changes in the apparent proportions of the 3 groups could be used to determine how much thyroxine was needed to reverse changes produced by thyroidectomy.  Rats that had been given brassica seed diets developed goiters.  In these rats, proliferation of basophil cells occurred.  The amount of thyroxine needed to reverse thyroidectomy changes was the same in rats receiving a brassica seed diet as in those on a normal diet.  This excluded the possibility of the brassica agent acting as a thyroxine antagonist or of its increasing the thyroxine requirement of the animal.  The effect of thyroidectomy was modified by diet.  When a diet contained no animal products, the acidophils lost their granules.  When acidophil granules were lost, growth ceased.  When aciodphil granules had been lost after thyroidectomy, daily doses of thyroxine restored the acidophils and caus ed growth to resume.  In animals given potent goitrogens, small doses of thyroxine did not inhibit activation of the thyroid gland, but with larg er doses basophilic changes regressed and the thyroid became inactive.  It is concluded that basophil changes were linked with the production of thyrotrophic hormone while acidophil changes which were regressive were related to the failure of growth hormone secretion.  When only a single change in hormone production occurs and only a single cell type is modified in the pituitary, that cell type is considered to be the site of production of that particular hormone.  By improved technique, it was shown that the basophil cells were of 2 types: "thymotrophs," which prod uced thyrotrophin, and "gonadotrophs," which produced gonadotropin.  The granules were considered to be the stored hormone product of the cells.  It seemed that follicle stimulating hormone was secreted by 1 cell type and luteinizing hormone by another.  Each specific hormonal function was thought to be performed by a specific cell type.  In the fish pituitary gland, 5 distinctive cell types are recognizable by selective staining.  In human problems, the inactivity of the thyrotrophs in pituitary glands from Graves' disease patients confirms that the source of thyroid stimulation comes from outside the pituitary gland.  In Cushing's disease, that the adrenal stimulation was caused by basophilic adenomata in the adenohypophysis was confirmed.


The current status of human pituitary cytophysiology.


On the histogenesis of shark enamel.

On the histogenesis of shark enamel.


Sea-blue histiocytes in marrow in Batten-Spielmeyer-Vogt disease.


Prevention of Rh immunization. Evaluation of Rh (D) antibody and elaboration of its mechanism of action by chromium-51 RBC clearing method.


Total hip replacement.

Total hip replacement.


Club foot; management and nursing responsibilities.


Management of cataract and cataract surgery.


The influence of a magnetic field on immunologic and enzymatic reactions carried out at a solid-liquid interface.


Symbolic apperception and Integral Psychology.


Rheumatoid arthritis and the family.

Rheumatoid arthritis and the family.


The facts about hair transplantation.

The facts about hair transplantation.


Cofactor of the "lupus anticoagulant".

Cofactor of the "lupus anticoagulant".


A radioimmunoassay of plasma estradiol-17beta with the use of polyethylene glycol to separate free and antibody-bound hormone.


The continuing carrier problem.

The continuing carrier problem.


The human major histocompatibility system.


Platelet adhesion to polymer surfaces.

Platelet adhesion to polymer surfaces.


Renal preservation with Plasmanate-albumin perfusate: successful clinical use.


The effect of chemical structure and surface properties of synthetic polymers on the coagulation of blood. III. In vivo adsorption of proteins on polymer surfaces.


Sheep scab: its diagnosis and biology.

Sheep scab: its diagnosis and biology.


The medical assistant. Training.

The medical assistant. Training.


The medical assistant. Discussion on assurance of qulaity, competence and accountability.


An in situ study of the hypothalamic neurosecretory system of some teleostean fishes.


[Contraception with low dose chlormadinone acetate. Clinical and histological results].


[Classification, value and significance of spermatogenic cells in human ejaculum].


Ph1-negative chronic myelocytic leukemia with a missing Y chromosome.


The fibrinolytic enzyme system in acute and chronic liver injury.


Investigations on plasma viscosity in patients with cirrhosis of the liver.


Heparinoids - a new inhibitor of experimental liver necrosis in rats.


Whipple's disease: etiopathogenesis, treatment, diagnosis, and clinical course. Case report and review of the world literature.


Studies on the integument of cestodes. I. Histology and histochemistry of the integument of the adult cestode Taenia hydatigena.


Lysosomal enzyme activities in the rectal gland of marine elasmobranchs.


Some remarks on the PAS reaction in semithin sections of Epon-embedded tissues.


Nature of the protein and the mode of stabilization of the cuticular spines of liver-fluke Fasciola hepatica (L.).


Comparison between morphological changes and histamine release induced in rat mast cells by human allergic sera and specific allergen.


Leukocyte migration inhibition by brain tissue antigens in acute inflammatory diseases of the nervous system.


Cupric sulfate-thionin method to demonstrate degeneration of neurofibrils in an Alzheimer case.


Observations on a glycoprotein isolated from human aorta.


Some aspects of the pathogenesis of prostatic hyperplasia.


Structural correlates of the mechanism of action of indirect sympathomimetic amines.


Electron microscopy of bone marrow following the intravenous injection of colloidal gold.


Benign hyperplasia of the human prostate exposed to steroid hormones in organ culture.


Interaction between skid row people and law enforcement and health professionals.


Curriculum design for the generalist health care technician.


Schistosoma mansoni: cercaria to schistosomule.


On the ultrastructure of the lymphoplasmocytes.


Studies on the function of adrenodoxin and TPNH-cytochrome c reductase in the mitochondria and microsomes of adrenal cortex, utilizing immunochemical techniques.


A peculiar t(21 ; 14) translocation, associated with a pericentric inversion of the Y chromosome in a mongol boy.


Presumably balanced translocations involving the same band of chromosome No. 4 found in two mentally retarded, dysmorphic individuals.


Occupational hazards in anesthesia: survey of blood enzymes, morphology and serum proteins in anesthesia residents.


Haemodynamic side-effects of pancuronium.


In vitro system for production of mouse mammary tumor virus. An in vitro system for production, purification, and concentration of mouse mammary tumor virus is described. Monolayer cultures of C(3)H mouse mammary tumor cells propagated at 34 C in roller bottles in the presence of dexamethasone, a glucocorticoid hormone, release B-type particles which possess ribonucleic acid and a ribonucleic acid-dependent deoxyribonucleic acid polymerase. One thousandfold concentration by ultracentrifugation with subsequent gradient fractionation yielded > 7 x 10(10) particles per ml in the 1.16- to 1.18-g/ml region. Mouse mammary tumor virus produced in this system was free of detectable C-type virus.


The techniques of surgery possible in incurable obstructive carcinoma of the corpus ventriculi.


Criteria for preparing, evaluating, and standardizing iodinated globulins for radioimmunoassay procedures. Procedures were examined for labeling immune globulins with radioactive iodine using chloramine-T as the oxidizing agent. The chloramine-T method was critically evaluated to establish the optimal conditions for preparing iodinated globulins with high specific radioactivities without impairing their immunospecificities for use in in vitro radioimmunoassays. The results showed that the use of 100 mug of chloramine-T per ml, 500 to 1,000 muCi of Na (125)I per mg of protein, and a 10-min oxidation reaction time produced globulins of both high specific radioactivities and immunospecificities. Criteria were established for evaluating and determining optimal concentrations of iodine-labeled globulin for use in radioimmunoassays. The results of this investigation indicated that the amount of labeled indicator globulin used in radioimmunoassays should be based upon protein concentration rather than radioactivity.


Familial cold urticaria. Clinical findings.


Immunosuppressive and cytotoxic drugs in dermatology.


Lupus erythematosus-like lesions in newborn infants.


Citrate lyase from Rhodopseudomonas gelatinosa: purification, electron microscopy and subunit structure.


Virions released from the surface of leukovirus-producing cells.


[Diagnosis of cancer in hyperplastic nodes of the prostate].


The pacemaker patient and his management.


The roles of radiotherapy and cytotoxic drugs in the management of carcinoma of the esophagus.


The pharmacological mediation of the acute inflammatory response: a brief review.


Metabolic studies on myelin. Evidence for a precursor role of a myelin subfraction. Myelin prepared from brain tissue of the developing rat (15 days post partum) can be separated into several subfractions. These are (1) ;myelin-like' and ;purified myelin', by the technique of Davison and co-workers (Agrawal et al., 1970b) and (2) ;membrane fraction,' ;light myelin' and ;heavy myelin' by the discontinuous-sucrose-gradient procedure described in the present paper. ;Myelin-like' and ;membrane-fraction' subfractions appear to be similar in chemical properties, but different in detailed morphology by electron microscopy. Both fractions are related to myelin, on the basis of demonstrable myelin basic protein by polyacrylamide-gel electrophoresis in sodium dodecyl sulphate and the presence of a myelin-marker enzyme, 2':3'-cyclic nucleotide 3'-phosphohydrolase. These two fractions have a low lipid content (17% for ;myelin-like' and 40% for ;membrane-fraction' subfractions) compared with myelin (67-72%). No cerebroside was detected in these two fractions, whereas cerebrosides are a major component of myelin itself. The administration of [2,3-(3)H]tryptophan to young rats results in more rapid incorporation into proteins of the ;myelin-like' and ;membrane-fraction' subfractions when compared with incorporation into myelin. Data are presented which are consistent with a precursor-product relationship for conversion of ;myelin-like' and ;membrane-fraction' subfractions into myelin.


Peptides from myelin basic protein as substrates for adenosine 3', 5'-cyclic monophosphate-dependent protein kinases.


Anti-arrhythmic action of dilazep. Action on experimental arrhythmias induced by g-strophanthin (ouabain), epinephrine and aconitine.


Adult acute leukaemia.

Adult acute leukaemia. Seventy-eight adult patients with acute leukaemia were classified cytologically into 3 categories: acute lymphoblastic leukaemia (ALL), acute myelogenous leukaemia (AML) or acute undifferentiated leukaemia (AUL). The periodic acid-Schiff stain was of little value in differentiating the 3 groups. The treatment response in each group was different: 94% of patients with ALL (16/17) achieved complete remission with prednisone, vincristine and other drugs in standard use in childhood ALL; 59% of patients with AML (27/46) achieved complete remission with cytosine arabinoside and daunorubicin (22 patients), or 6-thioguanine and cyclophosphamide (2 patients), 6-thioguanine, cyclophosphamide and Adriamycin (1 patient), and cytosine and Adriamycin (1 patient); only 2 out of 14 patients (14%) with acute undifferentiated leukaemia achieved complete remission using cytosine and daunorubicin after an initial trial of prednisone and vincristine had failed. Prednisone and vincristine would seem to be of no value in acute undifferentiated leukaemia. It would seem also that no benefit is obtained by classifying all patients with acute leukaemia over 20 years of age as "adult acute leukaemia" and treating them with the same polypharmaceutical regimen. The problems posed by each disease are different and such a policy serves only to obscure them.


Eelctron microscopic studies of xeroderma pigmentosum: unusual changes in the keratinocyte.


Alpha-foetoprotein in rats with nephrotoxic serum nephritis.


Hereditary hypotrichosis simplex of the scalp. Evidence for autosomal dominant inheritance.


Metastatic mucus-secreting mammary carcinoma in the eyelid. Report of two cases.


X-linked congenital panhypopituitarism.

X-linked congenital panhypopituitarism. Two half brothers with panhypopituitary dwarfism are reported who have the same mother and different, unrelated fathers. The subject of hereditary panhypopituitarism is reviewed briefly. It is concluded that there are at least two forms of hereditary panhypopituitary dwarfism, one of which may be X-linked.


Current concepts on the ultrastructural pathogenesis of macular and lattice corneal dystrophies. Some thoughts on the ultrastructural genesis of the lesions in macular and lattice corneal dystrophy are reviewed. These two genetically determined diseases of the cornea are symbolized by two chemical complexes, namely glycosaminoglycans and amyloid; they raise many questions about the biologic behavior of the cornea and its constituent cells and matrix stroma. Though the lesions in these two diseases appear to be localized to the cornea, the possibility of other tissues and organs being involved cannot be excluded at present, particularly when one takes into account that adequate postmortem studies have not yet been performed on patients with macular or lattice corneal dystrophy. To distinguish lattice corneal dystrophy from other disorders of the cornea which also contain amyloid, the term primary hereditary corneal amyloidosis is proposed. This terminology would seem appropriate in view of the fact that not all affected members of a family develop lesions with a lattice pattern.


Lipoid proteinosis.

Lipoid proteinosis. Twenty-eight cases of lipoid proteinosis have been identified in a highly inbred White-Khoikhoi ("Hottentot") hybrid community living in Namaqualand, South Africa. The clinical manifestations of the disease are described, and a genetic analysis is presented. Genealogic studies have shown that the autosomal mutant gene for lipoid proteinosis was introduced into South Africa by a German settler and his sister in the mid-17th century. A great-grandson of that settler carried the gene to Namaqualand, where several generations of inbreeding have produced numerous affected homozygotes.


An approach to recidivism.

An approach to recidivism.


Carcinoma of the penis and bleomycin chemotherapy in Uganda.


Formation of a factor increasing vascular permeability during electrical stimulation of the saphenous nerve in rats. 1 Increased vascular permeability following electric antidromic stimulation of the rat saphenous nerve was observed in the skin area supplied by the nerve, confirming previous results by other authors.2 The phenomenon was not affected by pretreatment of the rats with diphenhydramine, burimamide or their combination; atropine, methysergide, methysergide plus diphenhydramine, carboxypeptidase B, acetylsalicylic acid, indomethacin or methiazinic acid. It was partially reduced by previous injection of cellulose-sulphate, a kininogen-depleting agent.3 Perfusates from the subcutaneous tissue of the paw area supplied by the saphenous nerve contained permeability increasing activity as shown by intradermal tests in other rats. This activity was present in perfusates collected during nerve stimulation but not in those collected before stimulation. It was not destroyed by heating to 100 degrees C, or by alpha-chymotrypsin or trypsin.4 Bradykinin-like activity may appear later in the perfusates, depending on the intensity of the stimuli.5 It is concluded that following electrical antidromic stimulation of the saphenous nerve a permeability increasing factor is released, possibly from nerves. It is dialysable and can be distinguished from acetylcholine, histamine, 5-hydroxytryptamine, plasma kinins, substance P, prostaglandins and high molecular weight proteins. The increased vascular permeability induced by this factor leads to plasma exudation and activation of the kinin system.


Studies on the metabolism of catecholamines in the central nervous system of the mouse. 1 The distribution of the metabolites of noradrenaline, 1-(3,4-dihydroxyphenyl)ethane-1,2-diol (DOPEG) and 1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol (MOPEG), in the brain of the mouse has been investigated.2 The rate of disappearance of the metabolites after inhibition of the enzyme monoamine oxidase has been used to estimate their turnover rates in the mouse hypothalamus. It was concluded that the turnover of DOPEG was much faster than that of MOPEG.3 When mice were treated with reserpine dissolved in 5% ascorbic acid solution there was an increase in the hypothalamic concentration of both MOPEG and DOPEG. However, similar increases in the concentrations of the two metabolites were seen when the animals were treated with 5% ascorbic acid solution alone.4 The administration of tropolone, an inhibitor of the enzyme catechol-O-methyl transferase, resulted in an increase in the concentration of DOPEG.5 Mice, exposed to a temperature of -15 degrees C showed increased hypothalamic concentrations of both DOPEG and MOPEG.6 The rates of formation in the mouse striatum of 3,4-dihydroxyphenylacetic acid (DOPAC) and 4-hydroxy-3-methoxyphenylacetic acid (HVA), acidic metabolites of dopamine, were compared with the turnover rate of dopamine, estimated from the rate at which this catecholamine disappears after treatment with alpha-methyl-p-tyrosine. It was concluded that the estimate of dopamine turnover obtained by this method is likely to be too large because of the compensatory feedback mechanism which is thought to play a role in the metabolism of dopamine in the brain.


Antigen-mediated macrophage adherence inhibition.


Differentiation of lymphocytes in mouse bone marrow.  II.  Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling.


Differentiation of murine thoracic duct lymphocytes into T and B subpopulations by computer cell-scanning techniques.


The role of immunoglobulin receptors on lymphocytes in production of MIF in guinea pigs.


Role of lymphocyte surface determinants in lymph node homing.


The human mixed-lymphocyte culture (MLC) interaction after in vivo allo-immunization. II. HL-A specificity of early proliferative response.


Tolerance induction to a thymus-dependent antigen in vitro: treatment of nonadherent cells with tolerogen biologically filtered in vitro.


Effect of in ovo treatment with cyclophosphamide on lymphoid system in chicken.


The influence of 2-mercaptoethanol (2-ME) treatment of IgG antibody on its ability to induce cytotoxicity in nonsensitized lymphocytes.


Studies on encephalitogenic fragments of myelin protein. IV. Synthesis of glycine analogs of tryptophan-containing fragment.


Studies on encephalitogenic fragments of myelin protein. III. Synthesis of H-Arg-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Asn-Arg-OH as an analog of encephalitogenic decapeptide.


Antibodies to collagen in patients with emphysema.


Diseases of the thyroid gland.

Diseases of the thyroid gland.


T-lymphocyte differentiation in vitro in primary immunodeficiency diseases.


Suppression of experimental allergic encephalomyelitis in Rhesus monkeys by a synthetic basic copolymer.


Immunochemical studies of fragments of bovine nasal cartilage proteoglycan subunit.


Disorders of the autonomic nervous system.  Chapter 2. Relavant aspects of pharmacology.


Predicting what antibodies an antigen will induce: the inadequacy of the determinant model.


Human acute leukemia cells with membrane-bound immunoglobulin.


Ultrahistochemical studies in the basal lamina of the visceral pleura of mice.


Meningiomatoid proliferation of arachnoidal cells after focal brain injury.


Localization of insulin on fat cell ghosts by ferritin labelled insulin antibodies.


Fluorescence cytochemical studies on oocyte growth in Chiton tuberculatum, with special emphasis on protein end-group methods.


Identification and isolation of a foetoprotein in the chicken.


Innervation of adrenal cells in the lizards Lacerta dugesi and Lacerta pityusensis.


The histology and histochemistry of the cuticle of females of Enterobius vermicularis.


Cytoarchitectonic structure of the subthalamic nucleus compared with adjacent structures in the rat.


Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. A deletion of the albino (c) locus on mouse chromosome 7 has been demonstrated using Q- and G-banding methods in a mouse heterozygous for the radiation-induced lethal albino allele, c(25H). The deletion, which is thought to be 1-6 cM long, represents about 7.6% of the length of the metaphase chromosome.


A metachromatic study of the distribution of acid mucopolysaccharides in the aortal wall of vertebrates.


Preparatory electroimmunodiffusion for making precipitins to selected native antigens.


Secondary antibody response elicited in vitro with chicken gamma globulin1-4.


Equine infectious anemia: detection of infections virus-antibody complexes in the serum.


Isolation of pure human peripheral blood T-lymphocytes using nylon wool columns.


Mast cell responses in mesenteric lymph nodes to infection of rats with the nematode, Nippostrongylus brasiliensis.


Two myeloma globulins IgG1-kappa and IgG1-lambda, from a single patient (Im). II. Their common cellular origin as revealed by immunofluorescence studies.


Two myeloma globulins, IgG1-kappa and IgG1-lambda, from a single patient (Im). I. Purification and immunochemical characterization.


Immunoglobulins of the marsupial Setonix brachyurus (Quokka). Characterization of three major serum classes, IgG2, IgG1 and IgM.


Separation of 'species' and major histocompatability antigen in the rat.


Cytochemical studies in Indian childhood cirrhosis.


Non-fluorescent Y-chromosome.

Non-fluorescent Y-chromosome.


Electron microscopic examination of cartilage in the syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism.


Vital staining of nerve fibres and endings.


The thyrotropin releasing hormone test in idiopathic pituitary dwarfism.


The cortico-nigral fibre tract. An experimental Fink-Heimer study in cats.


Experimental alteration of the coronal sutural area: a histological and quantitative microscopic assessment.


Biological significance and localization of antigenic determinant common to thiol proteases of plant origin.


Anionic sites of human erythrocyte membranes. II. Antispectrin-induced transmembrane aggregation of the binding sites for positively charged colloidal particles. The effects of affinity-purified antispectrin gamma-globulins on the topographic distribution of anionic residues on human erythrocytes membranes was investigated using collo ida iron hydroxide labeling of mounted, fixed, ghost membranes. Antispectrin gamma-globulins were sequestered inside ghosts by hemolysis and the ghosts were incubated for 30 min at 37 degrees C and then fixed with glutaraldehyde. The topographic distribution of colloidal iron hydroxide clusters on ghosts incubated with low (<0.05 mg/ml) or high (>5-10 mg/ml concentrations of sequestered antispectrin was dispersed, but the distribution at intermediate concentrations (0.1-5 mg/ml) was highly aggregated. The aggregation of colloidal iron hydroxide binding sites was time and temperature dependent and required the sequestering of cross-linking antibodies (antispectrin Fab could not substitute for gamma-globulin antibodies) inside the ghosts. Prior glutaraldehyde fixation or fixation at the time of hemolysis in antispectrin solutions prevented the antispectrin-induced colloidal iron site aggregation. The antispectrin reacted exclusively at the inner ghost membrane surface and the colloidal iron hydroxide bound to N-acetylneuraminic acid residues on the outer membrane surface which are overwhelming on the sialoglycoprotein glycophorin. These results were interpreted as evidence for a structural transmembrane linkage between the inner surface peripheral protein spectrin and the integral membrane component glycophorin.


Quality control in cervical cytology.

Quality control in cervical cytology. From surveys conducted by the authors it is concluded that the best and most acceptable quality control methods in cytology are those from within the laboratory. Most of these have results which can be reported centrally. Where the overall control and codes of practice are high, there the results are the most reliable, as sources of error from whatever cause are quickly brought to light. These conclusions are illustrated by data from the five centres and correlated in the tables.


Tietze's disease.

Tietze's disease. The material from a case of Tietze's disease has been examined histologically. A review of the literature on the pathology of this lesion correlated with the findings from this case indicates that there is a pathological lesion in the costal cartilage in this disease. This consists of an increased vascularity and degenerative changes with patchy loss of ground substance leading to a fibrillar appearance. Cleft formation may occur with mucoid debris which may undergo calcification. Hypertrophic changes may be present at the periphery. The aetiology still remains obscure.


Comparative cytogenetical and morphological studies in ovarian dysgenesis. In 14 cases of the Turner syndrome and pure gonadal dysgenesis streak gonads were studied histologically. In cases where the 46,XX line was unimpaired the blood vessels of the gonad showed severe degeneration in at least 30 to 50%. These streak gonads usually contained some of the characteristic ovarian elements as well as the vascular lesions. In gonosomal monosomy, on the other hand, a similar intensive vascular degeneration could not be found and the gonad consisted of indeterminate connective tissue. These observations are strong indications of a close correlation between karyotype and the histology of the streak gonad, which may supply further information on the manner and timing of the development of the streak gonad.


Recent findings on the chemical structure and biological activity of bacterial lipopolysaccharides.


Leukaemic reticuloendotheliosis: a morphological and immunological study of four cases. Morphological and immunological studies of four cases of leukaemic reticuloendotheliosis are reported. The findings indicate that leukaemic reticuloendotheliosis is a monoclonal B cell neoplasm in which the leukaemic cell expresses either Kappa or lambda light chain and delta heavy chain determinants. The similarity between this disease and chronic lymphocytic leukaemia is discussed.


Serological cross-reactions between Brucella abortus and Yersinia enterocolitica IX.


Lethal effect of lipopolysaccharides (endotoxins) of various enterobacteria.


Modified suprapubic prostatectomy (a report of 30 cases).


An experimental study on the treatment of enlarged prostate.


Effect of oestradiol-17beta and progesterone on the metabolism of testosterone by human prostatic tissue.


Some aspects of the development of the notochord in mouse embryos.


Cellular aspects of regeneration hormone influence in Nereis diversicolor.


The anoinic binding-sites at the cell surface after tissue dissociation and during the early phases of cell reaggregation.


The use of tutorial services and a self-study center.


Methylation of myelin basic protein by enzymes from rat brain.


Pleomorphic adenoma of the vulva.

Pleomorphic adenoma of the vulva.


The ultrastructure and time sequence of the early stages of paraquat lung in rats.


Congenital brain oedema of Hereford calves.


Quantitation of histological changes in the glomeruli in renal biopsy specimens from children: total and differential glomerular cell counts.


Pigmented periductal cells (ochrocytes) in mammary dysplasias: their nature and significance.


Studies on the pathogenesis of corneal arcus formation II. Immunofluorescent studies on lipid deposition in the eye of the lipid-fed rabbit.


The effects of hexachlorophane on the nervous system of sheep.


Fine structural alterations in the lungs of iprindole-treated rats.


New concepts in the evaluation of the abnormal Papanicolaou smear.


Australian itch: diagnosis, control and economic importance.


Involution of the post partum uterus of the ewe.


Letter: Capsid structure of bacteriophage lambda.


Blood groups of the dwarf chimpanzee (Pan paniscus).


Gamma-globulin allotypes of the Indonesians from Java-Madura, Indonesia.


Genetic and biochemical studies on drug-resistant mutants in Mycobacterium smegmatis.


Regular array in the cell wall of Lactobacillus fermenti as revealed by freeze-etching and negative staining.


Subtypes of hepatitis B surface antigen (HBsAg) in blood donors in Kumamoto, Japan.


Activity stain for the detection of cyclic nucleotide phosphodiesterase in polyacrylamide gels.


Letter: A study of lead concentrations in blood of children (and some adults) of Southern Tasmania.


Malignant liver carcinoid: the place of surgery and chemotherapy. Review and case presentation.


Effects of interferon on hemoglobin synthesis and leukemia virus production in Friend cells.


Elements of the secondary structure in the DNA, complementary to pigeon globin mRNA.


An electron microscopic study of the scrapie mouse and rat: further observations on virus-like particles with ruthenium red and lanthanum nitrate as a possible trace and negative stain.


A membrane-associated network of protein filaments in nerve cells.


Orthopedic nurse specialist (orthopedic surgeon,s nurse assistant).


Study of experimental hypertensive vascular lesions by ruthenium red staining technique.


Twenty-two years' experience in the medical management of juvenile thyrotoxicosis.


St. Christopher's Hospice.

St. Christopher's Hospice.


Vocational training in general practice: The evaluation of training programmes.


Rheumatoid arthritis and systemic lupus erythematosus (SLE).


Alpha-fetoprotein and teratomas of the testis.


Combination chemotherapy for testicular tumours.


Autoimmunity and lymphoid malignancy in New Zealand black mice.


Epidemiological and biochemical studies in filariasis in four villages near Bombay.


Carcinofetal antigens.

Carcinofetal antigens.


Studies on swinepox virus: fluorescence and light microscopy of infected cell cultures.


Ultrastructural studies on the bovine mammary gland with particular reference to glycogen distribution.


Higher frequency of a protein band in the cerebrospinal fluid from scrapie mice.


An audio-visual experience for nurses.

An audio-visual experience for nurses.


The structure of peripheral root dentin in young human premolars.


Age changes in juxtaodontoblastic capillaries of rat molars.


Chromosome banding pattern in acute myeloid leukaemia.


Classification of art into style periods; a factor-analytical approach.


The lymphocyte membrane.

The lymphocyte membrane.


Precursors of thymus lymphocytes.

Precursors of thymus lymphocytes.


Tissue localization of lymphoid cells.

Tissue localization of lymphoid cells.


Immunologic activities of thymus cell subpopulations.


Cell to cell interactions in the immune response.


New aspects of lymphocytes in immunity. Concluding comments.


Protein transport across the placenta.

Protein transport across the placenta.


Subtypes of hepatitis B antigen (HBAg) in Peru.


Electrophoretic separation of X- and Y-chromosome-bearing sperm in human semen.


Mineral oil granulomatosis of scrotum.

Mineral oil granulomatosis of scrotum.


The ultrastructure of the interfollicular epidermis of the hairless (hr/hr) mouse. II. Plasma membrane modifications during keratinization.


Anti-I (A + B): an autoantibody detecting an antigenic determinant of I and a common part to A and B.


Further data on HBs antigen subtypes - geographical distribution.


Agarose gel electrophoresis of the human red cell acid phosphatase.


The contribution of the scanning electron microscope to studies on the influence of chemotherapeutics on NK/Ly ascites lymphoma.


Immunopathology of glomerulonephritis.

Immunopathology of glomerulonephritis.


Median cleft of the upper lip and jaw.

Median cleft of the upper lip and jaw.


Modification of Csapody's method of conjunctival sac reconstruction in complete obliteration of the cavity.


Plasty of hypo- and aplastic breasts using adipodermal grafts.


On problems involved in the sterilization of transplantation material.


Peripheral nerve homografting. A preliminary report.


Syndrome of arteriomesenterial duodenal compression in children with burns.


Rapid technique for contrasting embryonic tissues in secondary palate development studies.


Cephalometric study of families with clefts.


In memoriam Assistant Professor Teobald Adamczak, M.D.


Effects of artificial intraocular pressure elevation on the outflow facility and the ultrastructure of the chamber angle in the vervet monkey (Cercopithecus ethiops).


Carbonic anhydrase histochemistry, a critical study of Hansson's cobalt-phosphate method.


Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin.


Histochemical characteristics of human mast cells.


Effect of cycloheximide on induced autophagy in epithelial cells of the seminal vesicle of mice.


Accessory neurosecretory cell groups in the rat hypothalamus.


Antigenic profile of neuraminidases of influenza A viruses isolated in 1957-1973.


Richardson's modified Southgate's mucicarmine stain compared to Mayer's mucicarmine.


Injury and repair of arterial tissue: histochemical alterations.


Injury and repair in arterial tissue: contraction and blebbing of endothelial cells in atherogenesis and thrombogenesis and abnormal secretion of sex hormone in Takayasu's disease.


Humoral immunity in relatives of patients with active chronic hepatitis.


Nursing management of transurethral resection of the prostate.


Antigenic structures of hen egg-white lysozyme. IV. Antigenicity of the second loop.


Amino acid sequence of the N-terminal 139 residues of light chain derived from a homogeneous rabbit antibody. The amino acid sequence of the N-terminal 139 residues of the L (light) chain derived from a homogeneous rabbit antibody (designated BS-1) to type III pneumococci was determined. A combination of methods involving tryptic cleavage restricted to the 2 arginine residues of the molecule and mild acid hydrolysis of a labile peptide bond between the V (variable) and C (constant) regions of the L chain (Fraser et al., 1972) allowed the isolation of two large peptides comprising the entire V region (residues 1-109); these peptides were suitable for automated Edman degradation. The complete sequence analysis of the V region was carried out with only 4mumol of L chain. This material was homogeneous, although minor variant sequences, if present at the 10% value, would not have been detected. The L chain contains 3 intrachain disulphide bridges, whose pairing was established by diagonal electrophoresis: there is one V-region bridge between positions 23 and 88 and one C-region bridge between positions 134 and 194; the third one connects V and C domains between positions 80 and 171. When compared with the basic sequence of human kappa chains, rabbit L chain BS-1 appears to be more similar to the V(KI) prototype sequence than to V(KII) or V(KIII) sequences, where V(KI), V(KII) and V(KIII) represent subgroups I, II and III respectively of V regions of kappa light chains. The V regions of rabbit heavy and light chains are homologous to each other. The presence of two clusters of 3 glycine residues in positions 94-96 and 99-101 respectively is remarkable. Residues 94-96 may be related to antibody complementarity whereas residues 99-101 function probably as a pivot permitting the combining region of the L chain to make optimal contact with the antigenic determinant (Wu & Kabat, 1970).


Amino acid sequence of the smaller basic protein from rat brain myelin. 1. The complete amino acid sequence of the smaller basic protein from rat brain myelin was determined. This protein differs from myelin basic proteins of other species in having a deletion of a polypeptide of 40 amino acid residues from the centre of the molecule. 2. A detailed comparison is made of the constant and variable regions in a group of myelin basic proteins from six species. 3. An arginine residue in the rat protein was found to be partially methylated. The ratio of methylated to unmethylated arginine at this position differed from that found for the human basic protein. 4. Three tryptic peptides were isolated in more than one form. The differences between the two forms of each peptide are discussed in relation to the electrophoretic heterogeneity of myelin basic proteins, which is known to occur at alkaline pH values. 5. Detailed evidence for the amino acid sequence of the protein has been deposited as Supplementary Publication SUP 50029 at the British Library (Lending Division) (formerly the National Lending Library for Science and Technology), Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies may be obtained on the terms given in Biochem. J. (1973) 131, 5.