Structure of isolated plant Golgi apparatus revealed by negative staining. Sucrose-gradient-purified dictyosomes of plant Golgi apparatus appear, after glutaraldehyde stabilization, as stacks of highly fenestrate and tubate cisternae when negatively stained with phosphotungstic acid, shadowed with heavy metal, or OsO(4)-stained in thin section. The tubular proliferations (diameter 200 to 400 A) extend for several microns from the central region and are united at intervals into an anastomosing network. Associated with the tubules are two kinds of vesicles which are distinguishable on the basis of texture, size, shape, and staining characteristics. One vesicle type is rough-surfaced, nearly spherical, and of uniform dimensions (diameter approximately 600 A). Metal shadowing shows that these vesicles remain spherical after drying. The other vesicle type is smooth-surfaced and varies in both size and shape. Intercisternal elements are revealed, by negative staining, on the surface of internal cisternae after fragmentation of the dictyosome. The progressive differentiation of cisternae from the forming face to the maturing face is observed in thin sections of these isolated preparations. The morphological characteristics observed in negatively stained dictyosomes indicate regions of functional specialization within the dictyosome cisternae and reveal a dictyosome structure more extensive than that envisioned from sections.


Assessment of two tests of thyroid function: serum protein bound iodine and radioiodine tracer test.


Uric acid in human plasma. V. Isolation and identification of plasma proteins interacting with urate.


Acute phase protein in serum of women using hormonal contraceptives. Acute phase protein precipitating sonatic C-polysaccharide of pneumococci appears in serum of women under treatment with hormonal contraceptives in a significantly higher number of cases when compared with control groups. The summarized results of three preliminary studies show that in 80 control serums there were four positive specimens (5 percent) and in 80 serums from women using hormonal contraceptives there were 58 positive specimens (72.5 percent).


Biodegradation of the gamma isomer of benzene hexachloride in submerged soils. Determination of the residual gamma isomer of benzene hexachloride (gamma-BHC) by gas chromatography showed that the insecticide persisted longer in sterilized flooded soils than in nonsterilized flooded soils. A second addition of gamma-BHC to one of the nonsterilized soils. (55 days after the first application) disappepsilonared more rapidly than the first addition. These results strongly indicate biodegradation of gamma-BHC in flooded soils.


Histochemistry of the neurosecretory substance. The fraction accounted for the neurosecretory substance selective staining by the chrome-alum hematoxylin and the aldehyde-fuchsin.


Effect of cortisone on anaphylactic shock in the guinea pig.


Refsum's disease (heredopathia atactica polyneuritiformis). An inborn error of lipid metabolism with storage of 3,7,11,15 tetramethyl hexadecanoic acid formal genetics.


Refsum's disease (heredopathia atactica polyneuritiformis). An inborn error of lipid metabolism with storage of 3,7,11,15 tetramethyl hexadecanoic acid. A review of the clinical findings.


Effect of antigen on the structural configuration of homologous antibody following antigen-antibody combination.


Differentiation of diffusing proteins according to their geometrical patterns.


A serological study of primary thymic neoplasms.


Some relations between the structure and the antibacterial activity of natural coumarins.


Complement components in three pathological sera: relation to clinical states.


Phagocytosis and immunity. The kinetics of phagocytosis.


Advantage of three combined diagnostic procedures with I-131 for the evaluation of thyroid disorders.


Classification of immunoglobulins in the dermo-epidermal junction in lupus erythematosus.


Serological activity in myeloma type golbulins.


Observation of the protective effect of live measles vaccines in the first year after vaccination.


Armour's "Letter" for hypothyroidism.

Armour's "Letter" for hypothyroidism.


Study of contamination of the atmosphere by injurious road transport and industrial products.


A study of the relationship between the mineralisation of dentine and its staining with haematoxylin in decalcified sections.


Ferritin in synovial cells in patients with rheumatoid arthritis.


Pathology of experimental haemarthrosis.


Protein concentration of cantharides blisters in rheumatoid arthritis.


Substructure in negatively stained microtubules of mammalian blood platelets.


Conflict and violence.

Conflict and violence.


Some observations on the histochemical localisation of phosphorylase in the nervous tissues of parrot (Psittacula krameri).


Some ultrastructural changes in adrenal cortical cells of rat after hypophysectomy and following ACTH administration.


Specific inhibition of mast cell disruption in vitro.


The innervation of the periodontal membrane as observed by the apoxestic technique.


Immunohistochemical study of human malignant melanoma for the presence of gamma globulin.


Concentration of gamma-A-globulin in serum, saliva, and nasopharyngeal secretions of infants and children.


Use of visual memory in teaching written language skills to deaf children.


Localization in the kidney of antibodies to human skin and malignant melanoma.


A method for eliciting naming behavior from aphasic patients.


Periodontal disease in experimental animals subjected to chronic cold stress.


The gamma globulins. IV. Therapeutic uses of gamma globulin.


Clinical and histological evaluation of gingival massage in the treatment of chronic gingivitis.


Studies of the biosynthesis of thyroxine. II. Solubilization and characterization of an iodide peroxidase from thyroid tissue.


3-hydroxyanthranilic acid-mediated respiration in the inhibited respiratory chain.


Laboratory and clinical studies of 2-phenylalanine-8-lysine vasopressin (octapressin).


Behavior of immunoglobulins and some natural and acquired antibodies in chronic lymphatic leukemia.


Functional morphology of the pars intermedia of the rat hypophysis as revealed with the electron microscope. II. Correlation of the pars intermedia with the hypophyseo-adrenal axis.


Acute subvalvar mitral incompetence.

Acute subvalvar mitral incompetence.


Studies on alpha-2-macroglobulin. 3. Isolation and properties of Erinaceus alpha-2-macroglobulin.


The ability of patients with herdopathia atactica polyneuritiformis to alpha-oxidize and degrade several isoprenoid branch-chained fatty structures.


Elevated PBI, free thyroxine, and plasma protein concentration in man at high altitude.


Hyperparathyroidism in acromegaly. Findings in three cases.


Dietary regulation of cholesterol metabolism.


Further information on the antibody response to wart virus.


Central venous pressure and direct serial measurements as guides in blood-volume replacement. A comparative study in the same patients of the 2 methods for determining the amount of blood needed to obtain optimal blood-volume was conducted.  The central venous pressure (CVP) was monitored continuously by an intravenous catheter with its tip in the superior vena cava and connected to a saline-solution manometer with the zero point at 1/2 the anteroposterior diameter of the chest.  The measured normal central venous pressure ranged from 2-10 cm of water.  The blood-volume was measured with a semi-automatic instrument with which accurate serial determinations of blood-volume were obtained.  When the normal blood-volume was not known by direct measurement, it was calculated as the product of the patient's weight in kg times 65, 70, or 75 ml, depending on the body habitus and nutritional state of the patient.  6 case reports, culled from a study of over 80 patients in shock, in whom these 2 measurements were taken serially over a period of many hours, are reported.  They were selected in order to illustrate the variety of problems encountered in restoring blood-loss.  Direct measurement of the blood-volume with the aid of the modern computer devices yields reliable results even in advanced shock and facilitates precise correlation of the deficit, yet in patients with or without cardiac disability, and particularly those of middle or advanced age, monitoring of the CVP combined with serial blood-volume determinations provides the best guide.


Six cases of gamma-D myelomatosis.

Six cases of gamma-D myelomatosis.


How many blows make an F.E.V.1.0?

How many blows make an F.E.V.1.0?


Incidence of unwanted effects of dihydrocodeine bitartrate in healthy volunteers.


Measurement of A.D.P.-induced platelet aggregation and A.D.P.-splitting enzymes in plasma.


A test for pyloric regurgitation.

A test for pyloric regurgitation.


Prediction of ischaemic heart-disease.

Prediction of ischaemic heart-disease.


Prognosis in alcoholism.

Prognosis in alcoholism.


Who will vaccinate the vaccinators?

Who will vaccinate the vaccinators?


Postural control of urinary incontinence. The curtsy sign.


Immunology of sarcoidosis.

Immunology of sarcoidosis.


Anticoagulants during dental surgery.

Anticoagulants during dental surgery.


Isaac Harvey Flack.

Isaac Harvey Flack.


Jejunal biopsy: criteria and significance.


Histamine in guinea pig tissues.

Histamine in guinea pig tissues.


Polymorphism of heavy-chain genes in immunoglobulins of wild mice. The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains,44 of the mice were judged to be heterozygotes of various combinations and two had combinations of determinants that were unusual and could only have occurred in laboratory inbred mice by recombination.


The formation of immunoglobulins by human tissues in vitro. II. Quantitative studies.


The formation of immunoglobulins by human tissues in vitro. I. The methods and their specificity.


The formation of immunoglobulins by human tissues in vitro. 3. Spleen, lymph nodes, bone marrow and thymus.


The formation of immunoglobulins by human tissues in vitro. IV. Circulating lymphocytes in normal and pathological conditions.


Thyroid and steroid hormones and their relation to serum lipid concentrations in man.


Endemic goiter in Greece: metabolic studies.


Effect of prednisone on thyroxine-binding proteins.


Action of potassium iodide on thyroxine metabolism.


The effect of epsilon aminocaproic acid on the healing of extraction wounds in hamsters.


Chronic oral candidiasis and leukoplakia.


Effect of 5,5'-diphenylhydantoin on the metabolism of L-thyroxine-131-I in the rat.


Effects of structure and iodine content of the rat thyroid on the distribution of 127-I and 131-I between particulate and soluble thyroidal protein-bound iodine.


Further studies on inhibitory effect of excess iodide on thyroidal hormone release in the rat.


Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.


Involvement of the adrenal cortex in the appearance of rat slow alpha-2-globulin.


Vital staining of the granulated juxtaglomerular cells in the mouse kidney.


Transplantation of homo- and heterogenous tendon stored in meda solution.


The slow response of the human cortex to auditory stimuli: recovery process.


The fronto-striatal arrest response in man.


Rhythmic activity in the EEG of newborns.


Psychophysiological study on the depth of sleep in normal human subjects.


Behavior disorders of childhood.

Behavior disorders of childhood.


Electrophysiological and behavioural changes following selective and reversible inactivation of lower brain-stem structures in chronic cats.


Cortical sensory evoked potentials during limbic seizures.


Thalamo-cortical activity during increased gravitational stress.


The effect of stimulation of certain skin areas on the extensor motoneurons in the phasic reaction of a stretch reflex in normal human subjects.


Conative control of the contingent negative variation.


Adjustable stimulating and recording electrodes in brain of the unrestrained animal. A study of red nucleus.


Degenerative joint disease in cattle.

Degenerative joint disease in cattle.


Antigenic heterogeneity of human immunoglobulin A proteins. Two types of human IgA myeloma proteins were distinguished by immunochemical tests. Seven of 51 IgA-myeloma proteins contained an an tigenic determinant that was not de tected in the other 44 proteins. The distinctive antigenic site was not dem onstrated on either the heavy or light polypeptide chains.


Mast cells in rat gastrointestinal mucosa. I. Effects of fixation.


Mast cells in rat gastrointestinal mucosa. 2. Dye-binding and metachromatic properties.


Heterogeneity of anti-gamma-globulin factors detected by pepsin-digested human gamma G-globulin.


Reaction of human anti-antibodies with incomplete anti-D and its sub-units.


Picric acid staining of serum paraproteins.


The Nobel Foundation.

The Nobel Foundation.


Viral carcinogenesis.

Viral carcinogenesis.


The sodium pump.

The sodium pump.


Psychology of color preference in projection slides (from Kircher to Koch).


Macromolecular organization of hemocyanins and apohemocyanins as revealed by electron microscopy.


Absence of tolbutamide effect on anticoagulant therapy.


Atypical leukemia.

Atypical leukemia.


Primary amenorrhea. A cytogenetic and endocrinologic study of 18 cases.


Progesterone caproate in the treatment of endometrial cancer.


Studies on components of RNA in cardiac muscle with emphasis on the rapidly labeled 4 to 18 S fraction.


The gamma globulins. I. The structure and synthesis of the immunoglobulins.


Efficacy of Actifed as a decongestant.

Efficacy of Actifed as a decongestant.


Antibodies to human growth hormone. Development during therapy with human growth hormone.


The gamma globulins. II. Hypergammaglobulinemia.


Pendred's syndrome in South African Bantu brothers.


Graves' disease in a 5-year-old child.

Graves' disease in a 5-year-old child.


Accumulation of I-131 by channel catfish (Ictalurus punctatus) ovaries in vivo and in vitro.


Cytochemical studies on leucocyte alkaline phosphatase by naphthol AS-MX phosphate Fast Blue RR staining method from the pediatric aspects. I. Leucocyte alkaline phosphatase activity in healthy children.


Collagen profile in various clinical conditions.


Influence of adrenal cortex on synthesis of alpha-2-AP globulin of rat serum.


Some effects of oral contraceptives on carbohydrate metabolism.


Antigen induced histamine release from platelets of rabbits producing homologous PCA antibody.


Accumulation of serum-albumin at the operative wound site as a cause of postoperative hypoalbuminaemia.


Some effects of oral contraceptives on serum-lipid and lipoprotein levels.


Cephaloridine in the treatment of urinary proteus infections.


Differential nucleic acid metabolism of planarial segments.


Immunochemical glucagon in human pancreas, gut, and plasma.


Gastric secretion in early childhood.

Gastric secretion in early childhood.


Effect of cyclandelate on cerebral cortex perfusion-rates in cerebrovascular disease.


Absence of serum alpha-2 globulin in Niemann-Pick disease. A measure of hepato-cellular involvement.


Pool's cryoprecipitate and exhausted plasma in the treatment of von Willebrand's disease and factor-XI deficiency.


A blow on the head.

A blow on the head.


Inhibition of insulin secretion by a phaeochromocytoma.


Sugar diarrhoea.

Sugar diarrhoea.


Russell's viper and the cascade.

Russell's viper and the cascade.


Sudden death and phenothiazines.

Sudden death and phenothiazines.


Family-planning advice after abortion.

Family-planning advice after abortion.


Klinefelter's syndrome and diabetes mellitus.


Autoantibodies in Klinefelter's syndrome.


Effect of stimulation and suppression of the thyroid gland upon production of iodoprotein in man.


Use of phenazine methosulfate in enzyme histochemistry of human muscle biopsies.


On the double innervation of the parotid gland. An experimental study.


Induced metachromasia as an histochemical and histological method.


Cholinesterases in the walls of the great arterial trunks and coronary arteries.


Serum anti-gamma-G globulin factors in paroxysmal nocturnal hemoglobinuria.


Serum protein in an aging population with particular reference to evaluation of immune globulins and antibodies.


Methylene-C14-dioxyphenyl compounds: metabolism in relation to their synergistic action. The methylene-C(14) group is hydroxylated yielding formate-C(14) in the microsome-reduced nicotinamide-adenine dinucleotide phosphate system in vitro and yielding expired C(14)O(2), in living mice and houseflies. Methylenedioxyphenyl compounds apparently serve as alternate substrates for this enzymatic hydroxylation system of microsomes, and thus reduce the rate of metabolism and prolong the action of certain drugs and insecticide chemicals.


Electron microscopy of paraffin-embedded material in amyloidosis.


Intracerebral tumours of reticular tissue: the problem of microgliomatosis and reticulo-endothelial sarcomas of the brain.


Pathological, rickettsiological and immunofluorescence studies of a case of Q fever endocarditis.


Characterisation of an antiserum to human growth hormone and the localisation of the hormone in the normal adult adenohypophysis.


The pituitary acidophil: a comparison of its staining reactions with anti-human-growth-hormone and thioflavine T.


Argentaffin granules and lung tumours.

Argentaffin granules and lung tumours.


Radiation--facts versus fears.

Radiation--facts versus fears.


Hormone-induced alterations of ovarian morphology.


Eosinophil turnover in the rat during primary and secondary antibody response to tetanus toxoid.


Postoperative psychiatric disturbance.

Postoperative psychiatric disturbance.


Effect of local heat in vivo on the fine structure of the basement membrane and the sertoli cells of the rat testis.


Reversible agglutination of trypsinised red cells by a gamma-M-globulin synthesized by the human foetus.


Urinary hormone metabolites in cancer and benign hyperplasia of the prostate: a multivariate statistical analysis.


Antibody molecules: discontinuous heterogeneity of heavy chains. The heavy polypeptide chains of antibody ( and of gammaG-immnunoglobulin) molecules show discrete bands on disc electrophoresis. The same bands are present for chains from antibodies of the same or diverse specificities. Individual bands are of different intensities for chains from the different rabbits tested even if the antibodies are directed against the same hapten. The bands appear to represent classes of heterogeneous H-chains of the same size having discrete differences in mizobilities with respect to a single charge difference.


Alpha globulin injections and decreased gamma globulin production in chickens. Electrophoretic analysis shows a strong similarity in the blood serums of chickens subjected to egg parabiosis and of chickens repeatedly injected with fraction IV (alpha globulins). In both instances there is an evident rise in the albumin-plus alpha(1) titer and an evident decrease in the gamma globulin levels. These findings suggest that the injection of alpha globulins has the same serum effect on the animal as parabiotically induced blood chimerism, namely, a reduction in circulating gamma globulin (immunoglobulins?).


Gm(a) grouping in neonates and children.


Prevention of Rh-haemolytic disease: results of the clinical trial. A combined study from centres in England and Baltimore.


Spinal-fluid gamma-globulin and multiple sclerosis.


Immunoglobulin levels in atopic eczema.

Immunoglobulin levels in atopic eczema.


Inhibiting effect of desensitization on release of histamine from guinea pig lung by specific antigen.


The characterization of human antibody to heterologous serum protein.


Physicochemical properties of reaginic antibody. 3. Further studies on the reaginic antibody in gamma-A-globulin preparations.


Special aids for the 1967 National Children's Dental Health Week. Bureau of Dental Health Education.


Incorporation of protein and nucleic acid precursors into frog nervous tissue in vitro.


Initial dietary influences on antibody absorption in newborn puppies.


Immunophoretic evaluation of blood serum proteins in chickens. I. Changing protein patterns in chickens according to age.


Immunophoretic evaluation of blood serum proteins in chickens. 3. Effects of nutritional myopathy-producing diets deficient in vitamin E and sulfur amino acids.


Effect of condensed phosphates on vitamin D-induced aortic calcification in rats.


Serum proteins in NZB/Bl and related strains of mice.


Subgroups of gamma-A immune globulins.

Subgroups of gamma-A immune globulins.


The behavior of rabbit antigens and allotypic antibodies in experimental posttransfusion shock.


Audio-visual aids to learning.

Audio-visual aids to learning.


Globulins in dystrophia myotonica.

Globulins in dystrophia myotonica.


Thiochrome: a convenient synthesis from thiamine.


Quantitative N-terminal amino acid analysis by thin layer chromatography.


Studies on the serum gamma-A-globulin level. IV. Conditions with pathological proteins (M-components) in serum.


The serum gamma M-globulin level in health subjects, hypergammaglobulinemic patients and conditions with pathological proteins (M-components) in serum.


The influence of specific antibody on the disappearance of staphylococcal enterotoxin B from blood.


Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver.


Assay of materials used in immunofluorescence techniques. Samples of commercially available fluorescein isothiocyanate and conjugated antispecies globulins were evaluated. Only one of the samples was of very high quality. There was great variation in the quality of the conjugated globulin solutions and even the best of them showed defects.


Reconstitution of dried-up tissue specimens for histological examination.


The occurrence of abnormal serum proteins in patients with epithelial neoplasms. In a series of 99 patients with paraproteinaemia, nine had carcinoma without myeloma. A review of the literature suggests that this may be a significant association, and its theoretical and clinical significance is discussed.


The biology of fungous infections of the feet.


Immunologic structure of horse antitoxic beta-2a-globulin.


Antigenic determinants common to human immunoglobulins G and M: importance of conformational antigens. Antiserums produced against certain isolated human myeloma IgGglobulins and absorbed in order to show only individual antigenic specificity crossreact with certain Waldenstrom IgM-globulins. Some of the common antigenic determinants revealed by these cross-reactions depend on the tertiary and quaternary structure of the IgG and IgM molecules and are independent of their K and L light-chain antigenic types.


The orthochemistry of immune globulins.

The orthochemistry of immune globulins.


The pathochemistry of the immunoglobulinopathies.


Clinical and pathogenic immunoglobulinopathies.


Management of the gammopathies.

Management of the gammopathies.


Bacteria in Whipple's disease. Isolation of a Haemophilus strain from the jejunal propria.


Kidney lesions in rats with severe long-term alloxan diabetes. 2. Histochemical studies, comparison with human diabetic glomerular lesions.


In vitro abrogation of the inhibitory action of tumour ascitic fluid on the oncolytic reaction.


Detection of preclinical atherosclerosis.


A comparative study of the effects of morphine in unanaesthetized and anaesthetized cats.


Small bowel obstruction secondary to hematoma of the mesentery.


Isolation and amino-acid sequence of beta-LPH from sheep pituitary glands.


Electrophoretic mobility of an immune globulin from rainbow trout serum.


Gm(b) factor in the gamma globulin of non-human primates.


Comparative investigation of immune globulins of various vertebrate classes.


Clinical and pathological observations with special reference to the nervous system in Macaca radiata infected with Kyasanur Forest Disease virus.


The staining of malaria parasites.

The staining of malaria parasites.


Immunoelectrophoretic analysis of guinea pig sera.


Mechanism of the inhibition of enzymatic halogenation by antithyroid agents.


Recombination of heavy and light chains of human gamma-a-myeloma proteins: formation of hybrid molecules and configurational specificity. The present studies demonstrate that the conditions necessary for reductive cleavage, isolation, and recombination of L and H polypeptide chains of human gammaA-myeloma globulins parallel those required for similar manipulation of the component chains of gammaG-globulin. Specificity of recombination was shown for chains derived from the same protein. In contrast, no intradass preferential recombination was demonstrable. Hybrid molecules, formed by reassociation of noncovalent bonds, could be synthesized from isolated chains of two immunoglobulin classes resulting in the formation of molecules of the type gammaA-H-gammaG-L and gammaG-H-gammaA-L. Several sera containing both gammaA- and gammaG-"monoclonal" peaks were studied, one of which demonstrated the L chains associated with both peaks to be identical both by electrophoretic mobility in acid-urea gel and antigenic analysis. The possibility is considered that this case represents a naturally occurring analogue of the artificially produced hybrid molecules described in this study. Configurational antigenic specificity of gammaA-myeloma proteins, imposed by the presence of kappa L chains in native and appropriately recombined molecules, provides a further indication of the importance of noncovalent bonds in the establishment of the quaternary structure of these proteins.


Role of the thymus in tolerance. 3. Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats. Rats subjected to high doses of whole-body irradiation, with simultaneous shielding of the thymus or spleen, recovered at 3 wk the ability to develop delayed sensitization and to form hemagglutinating and precipitating antibody following foot-pad injection of BgammaG in complete adjuvant. Injection of BgammaG into the shielded thymus immediately after irradiation, in amounts between 20 gammag and 40 mg, inhibited these response to later challenge partially or completely. A comparable effect on immune responses to BgammaG was not seen after injection of heterologous antigen (Ea) intrathymically, BgammaG intraperitoneally, or BgammaG into the shielded spleen. However high doses (20 or 40 mg) of antigen given by the latter routes resulted in some diminution of later response. Arthus reactivity recovered partially in the spleen-shielded group and was readily suppressed by intrasplenic administration of antigen.


Genetically determined antigen of the Ne subgroup of gamma-globulin: detection by precipitin analysis. A genetic antigen, Gm(n), has been described for the Ne subgroup of gamma-globulin previously devoid of Gm factors. It was detected by precipitin tests with a primate antiserum to Ne-type heavy chains. A relation to the Gm(b) antigens of the Vi subgroup and the Gm(f) and Gm(y) antigens of the We subgroup was apparent. The availablity of genetic antigens for the heavy chains of three subgroups of gamma-globulin with varying relationships in different populations offers an approach to the mapping of the genes concerned.


Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain. There is a positive correlation between the concentration of immunoglobulin-G in plaques of demyelination due to multiple sclerosis (as well as in white matter of normal appearance) and the concentration of this globulin in the cerebrospinal fluid. The tentative conclusion drawn from these results was that, in patients with multiple sclerosis, the increase in immuno-globulin-G in the cerebrospinal fluid is a reflection of an excess of this globulin in the brain.


Correlation of localization of alkaline and acid phosphatases with morphological development of the rat kidney.


Morphological variability of keratohyalin.


New aspects of immunogenetic relations between child and mother. I. Children produce antibodies against their mother's antigen.


Electronmicroscopic studies of isolated yeast mitochondria with negative staining and thin sectioning methods.


Extracts of plasma and serum toxic for mammalian cells cultured in vitro.


Growth hormone replacement therapy.

Growth hormone replacement therapy.


Ultrastructural studies in hypertension. I. Comparison of renal vascular and juxtaglomerular cell alterations in essential and renal hypertension in man.


Ultrastructural studies in hypertension. II. Renal vascular changes in progressive systemic sclerosis.


The antigastric-antibody test as a screening procedure for vitamin-B12 deficiency in psychiatric practice.


Enzyme and isoenzyme studies in preinvasive carcinoma of the cervix.


Quantitative estimation of bilirubin in liquor amnii.


Long-term assessment of steroid therapy in childhood nephrosis.


Hypergammaglobulinaemia, antibody deficiency, autoimmune haemolytic anaemia, and nephritis in an infant with a familial lymphopenic immune defect.


Candida albicans and the contraceptive pill. 14 women with a history of taking a combined oral contraceptive (norethynodrel plus mestranol) were studied and were found to have vaginal candidosis which commenced after an average period of 9 months from start of contraceptive therapy.  4 sexual contacts (men) of those women taking the pill were also discovered to have vaginal candidosis; they had presented with candidal balanoposthitis.  4 other men had clinical manifestations suggestive of balanoposthitis caused by hypersensitivity to the candidosis of their sexual partners.  Nystatin was a satisfactory treatment in most cases; however, 2 women had to stop using the pill because of frequent relapses of yeast infections.


A study of retinal vascular occlusion using fluorescein angiography.


The effects of propantheline on gastric-acid secretion after vagotomy.


Haemodynamic and metabolic effects of hyperbaric oxygen in myocardial infarction.


Effect of anti-lymphocyte globulin on kidney disease in (N.Z.B. x N.Z.W.) F 1 mice.


Blood-gas changes after acute myocardial infarction.


A simple device for external cooling.

A simple device for external cooling.


Madras--and after.

Madras--and after.


How much illness do viruses cause?

How much illness do viruses cause?


Abnormal calcification of cartilage.

Abnormal calcification of cartilage.


The pink spot: a red herring?

The pink spot: a red herring?


Errors in the classification of fatal pericarditis.


Fluoridation.

Fluoridation.


Chemotherapy in Burkitt's Tumour.

Chemotherapy in Burkitt's Tumour.


Methyldopa and hemolytic anemia.

Methyldopa and hemolytic anemia.


Fine structure of lily pollen tubes following various fixation and staining procedures.


The role played by the natural anti-thyroidal substances of food and fodder in the apparition of endemic goitre.


Immunization with protein-cellulose co-polymer (immunosorbent).


A rapid fluorochromatic tissue stain for frozen section diagnosis.


How topical application of fluorides protects teeth.


Effect of aortic-caval fistula on experimental atherosclerosis in dogs.


A strain of transplantable thyroid gland tumor of rats.


Unusual case of a nonagenarian with reticulum-cell sarcoma presenting as acute haemolytic anaemia.


Cytochemical identification of protein amino acids in the cell coat of mouse ascites tumor cells.


Studies on the experimental salmonellosis. Hypersensitivity against the endotoxin and appearance of hyaline granules in mice immunized under various conditions.


Preparation and properties of 3,5-di-Op-anisoyl-1,2-dideoxy-D-erythropentofuranos-1-ene. Various p-anisoylated derivatives of D-ribofuranose.


The synthesis of N-benzylthieno[2,3-b]pyrrole.


Viruses in the aetiology of acute appendicitis.


The gamma globulins. II. Hypergammaglobulinemia.


Evoked responses to clicks and tones of varying intensity in waking adults.


Physicochemical properties and antigenic activity of fragments of human gamma-globulin obtained by action of ultrasound.


Animal experiments concerning the aetiology of viral hepatitis.


Electroencephalographic-behavioral dissociations during animal hypnosis.


Electroencephalographic studies in toads.


Demonstration of averaged operant potentials in the human EEG.


Unusual EEG in coma after cardiac arrest.


Electroencephalographic and clinical changes in an epileptic child during repeated photic stimulation.


A miniature stimulating electrode set.

A miniature stimulating electrode set.


The application of electro-luminescence to photic stimulation.


Permanently implanted recording electrodes for immature animals.


Cytochemical investigation of decidual cells of human placenta.


Pharmacodynamic correlations between acetylcholine and potassium.


Evidence that choline can exchange for hydrogen across proximal tubules of dogs.


Histaminergic transmission in a frog vagus stomach muscle preparation.


Acetylcholinesterase in Tribolium confusum Duval.


The proteolytic activity in brain.

The proteolytic activity in brain.


Metabolism in the crayfish Astacus astacus (L.). 3. Absence of cholesterol synthesis.


Emissions of polynuclear hydrocarbons from automobiles and trucks.


Changes in haemolymph proteins in first instar locusts.


Effects of strontium ions on heart muscle. I. Influences on contractility.


Effects of strontium ions on heart muscle. II. Influence on excitability, conduction and potassium efflux.


Studies on the phosphorylase activity in isolated perfused rat heart.


Vagal escape time in rabbit heart and effect of serpasil.


Unit activity of thalamic and hypothalamic neurons during thalamic spreading depression in rats.


Changes after splenectomy of plasma protein pattern in Banti's syndrome.


Effect of thiouracil-type drugs on the alpha-glycerophosphate dehydrogenase response to thyroxine analogs.


Wall charts. An aid to resuscitation.

Wall charts. An aid to resuscitation.


Further studies on the chemotactic factor of complement and its formation in vivo.


Some aspects of the surgical treatment of intracranial aneurysms.


Hemorrhagic diabetic retinopathy. Treatment by pituitary stalk section or by pituitary irradiation with protons at the Bragg peak.


Tolerance of turkey gamma-globulin in chickens.


Contributions of stereoencephalotomy to the body-mind problem.


Immune globulin levels in colostrum and breast milk, and serum from formula- and breast-fed newborns.


Experimental and clinical studies of radiosensitizers in brain tumors, with special reference to BUdR-antimetabolite continuous regional infusion-radiation therapy (BAR therapy).


Effect of immunosuppressive therapy on the intrarenal distribution of blood flow in dog renal allograft rejection.


Intracranial localization of substances used for brain scanning.


Long-term outcome of hyperthyroidism treated with antithyroid drugs.


Rapid redistribution of serum thyroxine during ether anesthesia.


Norethynodrel-mestranol and thyroid function.


Effect of L-tyrosine upon the protein bound iodine in thyrotoxicosis.


Elevated cord macroglobulins in the diagnosis of intrauterine infections.


Mechanism of a histochemical reaction differentiating between adrenaline- and noradrenaline-storing cells in the electron microscope.


Two-stage surgical treatment of complete transposition of the great vessels.


Fibrillation in empty and loaded ventricles. An experimental study of coronary artery ligation during partial and complete cardiac bypass.


Production of 7 S immunoglobulins in immunized guinea pigs.


Presence of identical antigenic determinants in the Fd fragments of gamma-1- and gamma-2-guinea pig immunoglobulins.


Ontogeny of the immune response. II. Characterization of 19S-gamma-G- and 7S-gamma-G-immunoglobulins in the true primary and secondary responses in piglets.


Studies on the mechanisms of hypersensitivity phenomena. XIV. Passive sensitization in vitro of human leukocytes to ragweed pollen antigen.


The immune response to azo-human gamma-globulin conjugates in mice tolerant to human gamma-globulin.


The immunologic significance of antigen induced lymphocyte transformation in vitro.


A possible role of gamma-A-immunoglobulin in herpes simplex virus infection in man.


Fatal brain damage after dental anaesthesia. Its nature, etiology, and prevention.


Fibrinolytic activity in pregnancy, during parturition, and in the puerperium.


Postmortem findings in 25 cases of sudden heart arrest in the perioperative period.


Relation between long-acting thyroid stimulator and thyroid function in thyrotoxicosis.


Myocardial infarction associated with severe factor-XII deficiency.


Effect of alteration of species source of insulin on insulin-antibody levels.


Effect of oestriol on platelet adhesiveness and fibrinolysis in men.


125-I-labelled fibrinogen in cerebral malaria.


Test for ovarian function and responsiveness leading to ovulation induction.


A diffraction method for measuring the average sizes and shapes of red blood-cells.


Spontaneous "transformation" of lymphocytes from the umbilical-cord vein.


Acclimatisation to cold.

Acclimatisation to cold.


Spontaneous regression of cancer.

Spontaneous regression of cancer.


Schistosomiasis.

Schistosomiasis.


An insulin hazard?

An insulin hazard?


Surgery under adverse conditions.

Surgery under adverse conditions.


Drug surveillance utilizing nurse monitors. An epidemiological approach.


A method for separation and quantitation of LDH isoenzymes on cellulose acetate.


The production of a state of active immunity to isologous and autologous serum proteins.


Role of gastroenterostomy in management of pancreatic carcinoma. Risk of duodenal obstruction after biliary bypass.


Studies on the serum proteins of chimeras. I. Identification and study of the site of origin of donor type serum proteins in adult rat-into-mouse chimeras.


Studies on the serum proteins of chimeras. II. Rat gamma globulin formation in neonatal mice with graft-versus-host reaction induced by rat spleen or thymus.


Kapok allergens.

Kapok allergens.


Carcinoma of the prostate: an analysis of 136 cases treated at the Veterans Administration Hospital, Tuskegee, Alabama, 1950-1960.


Combined positive inotropic interaction of quindonium and ouabain.


Fibrinolytic treatment of rheumatoid arthritis with phenformin plus ethyloestrenol.


Impotence in patients with temporal-lobe lesions.


Acetylsalicylic acid as a cause of pancytopenia from bone-marrow damage.


A transferable factor causing abnormal platelet behaviour in vascular disease.


Possible chemical factors in the postnatal development of rubella cataracts.


Effects of age on the loss of bone after gastric surgery.


Impaired delayed hypersensitivity in patients with lepromatous leprosy.


Nasal carriage of Staphylococcus aureus in diabetes mellitus.


Dependence of serum-uric-acid on haemoglobin and other factors in the general population.


Growth hormone and kwashiorkor. Role of protein in growth-hormone homoeostasis.


Porphyrin-binding effect of cholestyramine. Results of in-vitro and in-vivo studies.


Disposable arterial and venous sets with connectors for use with the modified two-layer Kiil kidney.


Tuberculosis and immigration.

Tuberculosis and immigration.


Coeliac disease.

Coeliac disease.


Aspirin and the blood.

Aspirin and the blood.


Chemotherapy of Burkitt's lymphoma.

Chemotherapy of Burkitt's lymphoma.


Changes in the incidence of neural-tube defects.


Blunt abdominal trauma in head injuries.


Some effects of oral contraceptives on serum lipid and lipoprotein levels.


Mitogenic action of papain.

Mitogenic action of papain.


Fatal poisoning with methaqualone and diphenhydramine.


Use of technetium-99m in studying thyroid physiology in the mouse: double label experiment with technetium-99m and iodine-125.


The reaction of some 1-trihaloacetyl-8-methylazulenes with base.


Constituents of Iva species. IV. Structure of pseudoivalin, a new guaianolide.


Testosterone metabolism in prostate; formation of androstan-17-beta-ol-3-one and androst-4-ene-3, 17-dione, and inhibitory effect of natural and synthetic estrogens.


Histological evidence against the view that the cat's optic nerve contains centrifugal fibres. 1. Degeneration that can be shown by the Nauta-Gygax technique in the orbital part of the cat's optic nerve does not begin until 10 days after intracranial transection of the nerve, though after enucleation of the eye it is conspicuous in 4 days.2. We were not able to tell, by any silver-staining technique applied to an optic nerve at any interval after an operation, whether at that operation the nerve had been cut peripherally only or both peripherally and centrally.3. From these and subsidiary observations we conclude that either the cat's optic nerve contains no centrifugal fibres detectable by silver staining and light microscopy, or, if there are such fibres, they are much less susceptible to prograde (Wallerian) degeneration and much more susceptible to retrograde degeneration than most of the centripetal fibres. The former is the simpler and, we suggest, the more likely conclusion.


Fifty years after Flexner.

Fifty years after Flexner.


Observations on mountain sickness in the Colombian Andes.


Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells.


Juvenile cirrhosis and allergic capillaritis of the skin. A hepato-cutaneous syndrome.


Cytogenetic investigation of survivors of the atomic bombings of Hiroshima and Nagasaki.


Hepatitis complicating chronic haemodialysis.


Experimental use of cetrimide in the prevention of wound implantation with cancer cells.


The use of soluble swabs in  exfoliative cytology of the bronchus and hollow viscera.


Hypermetabolic states.

Hypermetabolic states.


A miniature phlebogram device.

A miniature phlebogram device.


A device for simplifying the measurement of central venous pressure.


Catheter for bladder drainage.

Catheter for bladder drainage.


Pathogenesis of myotonia.

Pathogenesis of myotonia.


Direct-current shock for atrial fibrillation.


Led by the nose?

Led by the nose?


Genetics of schizophrenia.

Genetics of schizophrenia.


Mumps embryopathy.

Mumps embryopathy.


Absence of prophylactic effect of propranolol in myocardial infarction.


The incidence of urinary infection in 5000 pregnant women.


A controlled trial of propranolol in acute myocardial infarction.


An outbreak of urinary Pseudomonas aeruginosa infection acquired during urological operations.


Muscle dysfunction in hyperthyroidism.

Muscle dysfunction in hyperthyroidism.


Corticosteroid withdrawal in rheumatoid arthritis.


Congenital deformities and insulin antagonism.


Prolonged coma after head injury.

Prolonged coma after head injury.


A new technique for examining the leptomeningeal circulation.


Effect of corticotrophin on growth-hormone secretion in response to insulin-induced hypoglycemia in children.


Failure of oral propranolol to maintain relief from paroxysmal syncopal attacks in Fallot's tetralogy after its successful intravenous use.


A social-work service for Scotland.

A social-work service for Scotland.


Inhibition of experimental leukaemia by a combination of various factors.


Propranolol and myocardial infarction.

Propranolol and myocardial infarction.


The biology of tissue transplantation.

The biology of tissue transplantation.


Fibrinolysis and pulmonary embolism.

Fibrinolysis and pulmonary embolism.


Intensive therapy.

Intensive therapy.


Garden fertilisers as a source of salmonellae.


The Minister on administration of the N.H.S.


Contaminated areas in operating-theatres.


Derbyshire Neck. Thyroid abnormalities in the Derbyshire Peak district.


Oral contraceptives and carbohydrate metabolism.


The effect of dicumarol, diphacinone and pivalyl upon blood prothrombin time of chicks.


Visual aids: their use and abuse.

Visual aids: their use and abuse.


The menace of the exhaust.

The menace of the exhaust.


Alterations in the nocturnal sleep cycle resulting from LSD.


Electrocardiographic findings during bronchoscopy. The apnoeic oxygenation technique.


Analysis of the frequency/voltage ratio of the EEG in intracranial diseases.


Stimulus-response relationship in the production of after-discharges and their spread from intact cerebral gyri to neuronally isolated slabs.


Rhythmic bursts in the medullary reticular formation and their connection with agonal respiration during hypoxia and the post-hypoxic period.


A light-weight micro-pipette puller by vacuum.


A cytochemical study of cytoplasmic basic proteins in echinoderm oogenesis.


Quantitative cytophotometric studies of nuclear protein in Vicia faba following acute irradiation.


The depression of the immune response by serum protein fractions.


Gamma 1-antibodies in guinea-pigs infected with the cattle lungworm.


Passive haemagglutination for estimation of early and late anti-human gamma-globulin antibodies.


The role of mycobacteria and silica in the immunological response of the guinea-pig.


Immunologic unresponsiveness in the adult guinea pig. 3. Variation of the antigen and vehicle of suppression. Induction of unresponsiveness in the adult rat.


Gamma-A-immunoglobulin from rabbit colostrum.


Ontogeny of the immune response. I. Development of immunoglobulins in germfree and conventional colostrum-deprived piglets.


Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity.


Suppression of experimentally induced polyarthritis in the rat by heterologous anti-lymphocyte serum.


Risk of changing from ox to pig insulin.


Notation for genetic factors of human immunoglobulins.


Factors influencing the staining of histones in irradiated rat thymocytes.


The management of adequate anticoagulant therapy and its complications.


The effects of antigens and of phytohemagglutinin on rabbit spleen cell suspensions. Phytohemagglutinin (PHA) stimulated the rate of DNA synthesis in rabbit spleen cell suspensions. Unlike antigens, previous immunization to PHA was not necessary and the specific response could not be transferred by macrophages, although lymphocytes primed by incubation in PHA were able to stimulate other spleen cells not directly exposed to PHA. When rabbits were stimulated by in vivo immunization with antigens, spleen cells proliferating in response to antigen were stimulated to divide by in vitro contact with PHA. Using the technique of specific hemolytic plaque formation by individual cells synthesizing gammaM-antibody to sheep red cells (plaque-forming cells), no evidence was obtained that stimulation of cell division by PHA resulted in specific antibody formation, although the presence of antigen resulted both in stimulation of cell proliferation and the production of plaque-forming cells. The presence of both sheep red cells and PHA in the medium of the same cell suspensions did not enhance the production of plaque-forming cells although there was a summative effect on DNA synthesis.


Structural studies of human gamma-G-myeloma proteins of different antigenic subgroups and genetic specificities. 1. Peptide maps of Fc fragments or heavy chains of 36 G myeloma proteins and two "heavy chain disease" proteins belonging to the four gamma-chain subgroups revealed very striking similarities between them. However differences in a few peptides were noted. This was most pronounced for the Ge(gamma(2)d) subgroup which lacked three peptides characteristic of the other three subgroups. While Fc fragments from different proteins belonging to the same subgroup appeared very similar, minor differences in addition to those based on currently recognized Gm factors were occasionally noted. 2. Fc fragments from Gm(a+) We(gamma(2)b) proteins had a peptide previously shown to be characteristic of normal Gm(a+) gammaG-globulins. Fc fragments from Gm(a-) molecules belonging to the We(gamma(2)b), Vi(gamma(2)c), or Ne(gamma(2)a) subgroups, whether Gm(b+), Gm(f+), or Gm(-), had the peptide previously identified in Gm(b+f+) normal gammaG-globulin. This "non-a" peptide was absent in peptide maps from Gm(-) molecules of the Ge(gamma(2)d) subgroup which contained instead another peptide with the same electrophoretic mobility but migrating slightly further on chromatography. 3. Both the "a" and "non-a" peptides were pentapeptides having three amino acids in common, and differing in the other two. The "a" peptide contained one residue of lysine, aspartic acid, threonine, leucine, and glutamic acid. The "non-a" peptides prepared from Gm(b+), Gm(f+), and Gm(-) proteins were identical and contained one residue of lysine, threonine, and methionine sulfone, and two residues of glutamic acid. 4. Several possible mechanisms for the origin of these differences, and their possible role in serologic specificity are discussed.


The minister among the young doctors.

The minister among the young doctors.


Hydrocortisone and/or desiccated thyroid in physiologic dosage. XIX. Muscular dystrophy: creatine phosphokinase during thyroid and alpha-tocopheryl acetate therapy.


Cancer of the alimentary tract. A positive approach to palliation.


Pneumocystis carinii pneumonia and altered host resistance: treatment of one patient with pentamidine isethionate.


Polymorphonuclear leukocytes in immunologic reactions. The destruction of vascular basement membrane in vivo and in vitro. Vascular basement membrane was disrupted in the presence of polymorphonuclear leukocytes (PMN's) during two immunologic reactions: The Arthus phenomenon and the reaction to locally injected antibody to vascular basement membrane. This disruption was evidenced by (a) the inability of the basement membrane to retain circulating carbon, by (b) loss of antigenic constituents, and by (c) electron microscopic observation showing actual gaps in the structure of the vascular basement membrane. The factors within PMN's responsible for damage to isolated glomerular basement membrane in vitro were found by isolation procedures to be cathepsins D and E. Cationic proteins of PMN's were separable from the cathepsins. While inducing vascular permeability upon injection, these basic proteins failed to inflict the severe damage to the basement membrane observed in Arthus and antibasement membrane reactions. It is concluded that the full expression of these immunologic lesions requires destruction of the basement membrane possibly brought about by cathepsins D and E. Some of the physicochemical properties of these pathologically active leukocytic factors are given.


Frequent or severe respiratory infections in children.


Mammillary complex of cat brain--aspects of quantitative organization.


Initiation of irreversible differentiation in vaginal epithelium.


Presence of a "cell coat" rich in carbohydrate at the surface of cells in the rat.


Cells with filopodia cultured from human synovialis.


Glomerular ultrastructure in the kidney of a hibernating animal.


Intracytoplasmic membranes in Escherichia coli.


Freezing and in vitro culture of hamster teeth before transplantation and replantation.


Left lobe hepato-cholangio-jejunostomy in palliative treatment of malignant biliary obstruction.


Speaking at meetings.

Speaking at meetings.


Sound and visual teaching aids in obstetrics and gynaecology.


The epidiascope and television in medical teaching.


Immunologic aberrations in the Di Guglielmo syndrome.


Staining of blood cells with periodic acid/salicyloyl hydrazide (PA-SH). A fluorescent method for demonstrating glycogen.


Intussusception of the ileum in a horse. A case report.


Epididymitis of rams. Antibody in newborn lambs.


Measles--canine distemper relationship. The effect of measles viruses and their influence on subsequent challenge with Snyder Hill distemper virus.


Somatic projection to the orbital cortex of the cat.


Relationships of neuronal spike populations and EEG activity in chronic cats.


Rubrally evoked unitary potentials in ventro-lateral thalamus of cat.


Striatal connections and influences on somatosensory and photic projections to the hypothalamus.


Hippocampal electrical correlates of self-stimulation in the rat.


The effects of central stimulation and nasal air flow on induced activity of olfactory structures.


The periodic events of subacute sclerosing leucoencephalitis.


Auto- and cross-correlation of the EEG following unilateral caloric stimulation of the labyrinth.


Effect of beta-phenylisopropylhydrazine (JB 516) on the isolated cerebral cortex.


Insulating micro-electrodes by centrifuging.


A simple noise generator for use in neurophysiological and behavioral research.


Enhancement of antibody synthesis by 6-mercaptopurine. The administration of 6-MP to rabbits led to either suppression or enhancement of antibody production, depending on when the drug was given in relation to the antigenic challenge. Maximum enhancement of antibody synthesis was found when a small dose of BGG was administered 5 days after the last dose of a 1 wk course of 6-MP. There were no indications that the macrophage system or immunological memory was affected in animals with augmented antibody synthesis. It was proposed that enhancement of antibody production by 6-MP was due to nucleic acids released from cells killed or injured by the drug. It was suggested that lymphocytes incorporating these nucleic acids were transformed into specialized cells capable of direct and immediate stimulation by antigen and lacking immunological memory (hemocytoblasts). A relatively small dose of antigen was apparently capable of stimulating all the hemocytoblasts representing a given clone) with the result that large amounts of antibody rapidly appeared in the serum.


Mechanisms of immunologic injury of rat peritoneal mast cells. II. Complement requirement and phosphonate ester inhibition of release of histamine by rabbit anti-rat gamma globulin. There is an absolute requirement for C'1, C'2, C'4, C'3, and C'5 in releasing histamine from rat peritoneal mast cells sensitized with rabbit anti-rat gamma globulin. This conclusion is based upon the restoration of histamine-releasing capacity by adding highly purified complement components to sera deficient in one or more of these components. Of special advantage was the availability of sera from humans with inborn or acquired deficiencies in a single component. The p-nitrophenyl ethyl phosphonates block this reaction by inhibiting an antigen-antibody-activated esterase which exists in a phosphonate resistant precursor state until activated by the interaction of the sensitized mast cell and serum complement. There is almost complete disparity between the ability of the phosphonates to inhibit complement-dependent histamine release by rabbit anti-RGG and to inactivate C'1a. Even though C'1a is required for complement-dependent histamine release by rabbit anti-RGG, this is not the esterase being blocked by the phosphonates under the experimental conditions used. The pattern of inhibition by the phosphonates of the antigen-antibody-activated esterase required for complement-dependent, noncytotoxic histamine release is remarkably similar to that of the esterase required for homocytotropic antibody-mediated histamine release. One possible implication is that these two quite different modes of carrying out antigen-antibody-induced histamine release from rat peritoneal mast cells lead to activation of the same esterase and share a common pathway.


Mechanisms of immunologic injury of rat peritoneal mast cells. I. The effect of phosphonate inhibitors on the homocytotropic antibody-mediated histamine release and the first component of rat complement. The ability of a number of p-nitrophenylethyl, alkyl phenylalkyl, chloroalkyl, and aminoalkyl phosphonates to inhibit the homocytotropic antibody-mediated release of histamine from rat peritoneal mast cells has been tested. The effectiveness of these same phosphonates against the activated first component of rat complement (C'1a) has also been investigated. The rat mast cell esterase activated by the reaction of antigen and homocytotropic antibody resembles chymotrypsin in its reactivity with the phenylalkyl and chloroalkyl phosphonate, but is unlike this protease in its greater responsiveness to the 5-aminopentyl phosphonate relative to the pentyl phosphonate. The antigen-homocytotropic antibody-activated mast cell esterase and chymotrypsin, thus, appear to be similar, but different enzymes; i.e., they are parazymes (see reference 4, p. 501). There are distinct differences in the pattern of inhibition given by the phenylalkyl and aminoalkyl and alkyl phosphonates of the homocytotropic antibody-mediated histamine release from rat peritoneal mast cells and from guinea pig lung slices. On the basis of these differences it is concluded that the esterases activated by the combination of antigen and homocytotropic antibody on the mast cells of the two species are not the same. The arithmetic dose response curve found for the action of the phosphonates on the antigen-induced histamine release from rat peritoneal mast cells contrasted sharply with the logarithmic relationship found when these same inhibitors acted on the guinea pig lung system. This suggests that in addition to the antigen-antibody-activated esterases being unlike, the detailed mode of histamine release from the mast cells of the guinea pig lung differs from that of the mast cells of the rat peritoneum. Distinct and large differences were found in the pattern of inhibition of histamine release from rat peritoneal mast cells and of rat C'1a given by the phenylalkyl, and chloroalkyl and alkyl phosphonates implying that esterase activated by the combination of antigen with the sensitized rat peritoneal mast cells is not C'1a. Thus, the results with the peritoneal mast cells lead to the same conclusion as the previous work with guinea pig lung slices; i.e., the antigen-antibody-activated esterase involved in the homocytotropic antibody-mediated release of histamine is not part of the complement system.


Quantitative studies of the immunoglobulin sequence in the response of the rabbit to a somatic antigen. Employing a sensitive and immunoglobulin-specific assay method based upon antiglobulin augmentation, quantitative and qualitative aspects of the primary and secondary response of the rabbit to Salmonella typhimurium O antigens have been evaluated. These studies examine the validity of the method of assay for detecting and measuring gammaG- and gammaM-antibodies produced in response to whole organisms or its lipopolysaccharide. The results show that during the primary response gammaG-antibodies, not detectable by usual techniques, are produced in a pattern similar to that reported in animals stimulated by other classes of antigens. Moreover, the gammaG response following reinjection is characteristic of a secondary-type response. In contrast, gammaM-antibody levels after both primary and secondary stimulation rose equally to levels between 1 and 4 mg/ml. Despite increased sensitivity of detection and quantitative estimates of the actual molar concentration of each immunoglobulin, the minimal interval between gammaM and gammaG appearance in serum was not less than 1.5 days. The variable degree of augmentation of agglutination by antiglobulin reagent found during the immune response severely limits the quantitative usefulness of the methods developed. However, the data suggest that qualitative changes in anti-O antibodies interpretable as changes in avidity occur regularly during the immune response.


The stability of gamma-G-globulin and gamma-G related fragments in normal human urine.


Sensitization of mice with human IgA.

Sensitization of mice with human IgA.


Electrophoretic behaviour of H and L chains of human serum and colostrum gamma-globulin.


Long term treatment of paroxysmal cardiac arrhythmias with propranolol.


Clinical observations on the use of propranolol in disorders of cardiac rhythm.


Immediate effects of intravenous propranolol on various cardiac arrhythmias.


Determination of nonfibrin protein in fibrin clots by use of I-131-labeled protein fractions.


Alterations in thyroid physiology during pneumococcal septicemia in the rat.


Studies on deiodination occurring during pancreatin digestion of thyroid homogenates and its prevention by methimazole.


Stoichiometric relationships in mitochondrial accumulation of calcium and phosphate supported by hydrolysis of adenosine triphosphate.


A tool for clinical supervision.

A tool for clinical supervision.


Sulfonamide reactions in systemic lupus erythematosus.


Urine as a medium for bacterial growth.

Urine as a medium for bacterial growth.


Thyroidal suppression by triiodothyronine as a guide to duration of treatment of thyrotoxicosis with antithyroid drugs.


Treatment of acute retrobulbar neuritis with corticotrophin.


Activity and hepatitis.

Activity and hepatitis.


5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases.


Acute mitral incompetence after acute myocardial infarction, with successful early treatment by mitral-valve prosthesis.


Acid-base status in acute myocardial infarction.


Experimental "kuru" in chimpanzees. A pathological report.


Change partners.

Change partners.


Measurement of gastric acidity.

Measurement of gastric acidity.


Death of an asbestos worker.

Death of an asbestos worker.


Saul Eli Keidan.

Saul Eli Keidan.


Cellular changes accompanying the swarming of Proteus mirabilis. II. Observations of stained organisms.


Evaluation of acridine orange fluorescence test in viability studies on Escherichia coli.


A new procedure for the detection and enumeration of coagulase-positive staphylococci from frozen seafoods.


Sequential mestranol-chlormadinone acetate as an oral contraceptive.


Propranolol (Inderal) in cardiac arrhythmias.


Anticoagulant prophylaxis of thromboembolism in postsurgical patients.


Serial serum immunoelectrophoretic changes and activity of tuberculosis.


A fluorescent method for staining mast cells.


The application of immune electron microscopy to the demonstration of polyoma virus antigen in cultured mouse embryo cells.


The transmission of immunity from mother to young and the catabolism of immunoglobulins.


Effect of daily muscular exercise in patients with intermittent claudication.


Oxygen uptake during and after positive-pressure ventilation for the resuscitation of asphyxiated newborn infants.


Action of d-aldosterone on the electrolyte composition of human cells grown in vitro.


Acetone in alveolar air, and the control of diabetes.


The effect of oral sodium phosphate on the formation of renal calculi and on idiopathic hypercalcuria.


Transduction of antibiotic resistance in Staphylococcus aureus.


Amenorrhea after treatment with oral contraceptives.


Lipolytic activity of human pituitary fractions on isolated human adipose-tissue cells.


The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain.


The differentiation between oesophageal and cardiac pain.


William Arthur Edward Karunaratne.

William Arthur Edward Karunaratne.


Fluid deficit and drug effect.

Fluid deficit and drug effect.


Analgesic abuse and renal disease in North-East Scotland.


Portacaval transposition in the treatment of glycogen-storage disease.


Effect of propranolol in mild hypertension.


Oesophageal acid-perfusion in the diagnosis of precordial pain.


Immunological maturation in an infant of an agammaglobulinaemic mother.


Pulmonary embolectomy. A review of five cases with three survivals.


Coronary thrombosis and myocardial infarction.


Production of myopia in rabbits by raised body-temperature and increased intraocular pressure.


Measurement of regional cerebral blood-flow during carotid ligation.


The influence of red blood-cells on platelet adhesiveness.


Thymitis and myasthenia gravis.

Thymitis and myasthenia gravis.


Admissions and mortality in a children's ward in an urban tropical hospital.


Usefulness of intermittent positive-pressure respiration in the treatment of tetanus.


The laboratory diagnosis of chronic brucellosis.


A dangerous rodenticide.

A dangerous rodenticide.


Where hospital staff eat.

Where hospital staff eat.


Psychiatric Reports: whether and how.

Psychiatric Reports: whether and how.


Philip Henry Manson-Bahr.

Philip Henry Manson-Bahr.


Infusion through inferior gluteal artery for pelvic cancer. A preliminary report.


Patch test methods. 3. Influence of adhesive tape on test response.


The specific precipitation of reagins with an anti-beta-2A globulin serum.


Histamine release from the skin of patients with cutaneous mast cell disease (urticaria pigmentosa).


Griseofulvin and tuberculin sensitivity.


Studies of the mechanism of ultra-violet erythema formation. 3. A method for biological testing of ultra-violet radiation sources and substances affecting the degree of erythema.


Studies of the mechanism of ultra-violet erythema formation. IV. The histamine content of the skin during the process of ultra-violet and thermal erythema.


Enzymic differentiation of melanin phagocytosis and synthesis. A combined dopa-acid phosphatase reaction.


Bone marrow studies in lupus erythematosus.


Blood-tissue exchange in psoriatic skin.


Extensive micropapular sarcoidosis with joint manifestations in a child.


Biochemical studies in epidermolysis bullosa.


Penicillinase-producing staphylococci in the male urethra and their effect on penicillin treatment of gonorrhoea.


The connective tissue in mice and rabbits in experimental carcinogenesis.


Immunoglobulins in the skin of patients with lupus erythematosus.


Multiplication of measles virus in the presence of actinomycin D, aurantin or 5-bromodeoxyuridine.


The periodic acid-Schiff reaction in neutrophil leukocytes in untreated and myleran-treated chronic myelocytic leukemia. A quantitative microspectrophotometric study.


Unusual familial goiter associated with intrathyroidal calcification.


Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages.


Homoreactant: a naturally occurring autoantibody in rabbits. Homoreactant, a factor found in the serum of every normal rabbit tested thus far, reacts specifically with buried antigenic determinants on the Fab-fragment of papain-digested autologous and homologous gammaG-globulin. It appears that rabbits normally produce naturally occurring autoantibodies.


The serumtyrosine level as an index of thyroid function.


Atrioventricular junctional premature and escape beats with altered QRS and fusion.


Modification of the Brown and Brenn gram stain for the differential staining of gram-positive and gram-negative bacteria in tissue sections.


New aspects of immunogenetic relations between child and mother. II. An easy way to find maternal isoagglutinins alpha and beta on their babies' cells (a modified direct coombs tehnique).


Programmed group instruction.

Programmed group instruction.


Experimental amyloidosis. Structural relationships of amyloid and reticulin in tissue sections and isolated preparations.


Studies on myoinositol. 3. On the growth promoting and lipotropic action of some fatty acid esters of myoinositol.


Ultrastructure of human thyroid. A study of normal thyroid, untreated and treated diffuse toxic goiter.


Delayed ultrastructural changes in duodenal crypts of x-irradiated mice.


Automotive emissions after hot and cold starts in summer and winter.


Hypogammaglobulinemia, primary and secondary: immunoglobulin levels (gamma-G, gamma-A, gamma-M) in one hundred and twenty-five patients.


Production of tolerance in immunized mice and the effects of immunosuppression.


Studies of the control of thyroid function in endemic goiter in Eastern New Guinea.


Goitrous cretinism with chromosomal aberration and defect in thyroglobulin synthesis.


A new method for PAS stain of osmium-fixed araldite-embedded thick tissue sections.


Double-blind study of nasal decongestion with oxymetazoline and phenylephrine in asthmatic children with rhinitis.


Selective vulnerability of the blood-brain barrier in chemically induced lesions.


Horse anti-pneumococcal immunoglobulins. II. Specific mouse protective activity.


Uptake of dihydrostreptomycin by intact splenic cells cultured from immunized rabbits and its binding to the 40S ribosomal subunit.


Experimental specific serum therapy of Staphylococcus.


Monoclonal gamma-globulins in ferrets with lymphoproliferative lesions.


A comparative study of amniotic fluid, maternal sera and cord sera by disc electrophoresis.


Effect of 1-methyl-2-mercaptomidazole (methimazole-tapazole) on the DNA content of the rat thyroid gland.


Changes in alpha-macroglobulin during malaria in the duckling.


Termination of acquired immunological tolerance in mice with antigen aagregates.


Effect of passive immunization on the dental caries incidence of caries-susceptible rats.


Thyroidectomy.

Thyroidectomy.


The value of protein-bound iodine and triiodothyronine resin uptake in assessing thyroid function.


Studies of the effects of salicylate in hyperthyroidism.


Organochlorine pesticides in gallstones.


Studies on experimental insulin immunity. I. Dynamics of insulin immunity in the guinea pig.


The passive transfer of delayed hypersensitivity in the guinea-pig. I. The synergic effect of immune cells and immune serum on the 24-hour skin reaction and a study of the histology.


The synthesis of radioactive fluorescein isothiocyanate.


Histamine release from leukocytes of hypersensitive individuals. I. Use of several antigens.


The senescent sequences of normal processes.


Permeability of incipient carious enamel lesions.


Cutaneous leishmaniasis encountered in Philadelphia.


Electroencephalographic recordings from actively sensitized animals after various routes of challenge.


The epidemic of polymorph toxic erythema in the Netherlands in 1960. The so-called margarine disease.


On the allergic origin of the Jarisch-Herxheimer reaction.


Allergy to chromium, nickel and cobalt.

Allergy to chromium, nickel and cobalt.


The frequency of allergic diseases among relatives to patients with allergic eczematous contact dermatitis. A preliminary report.


Routine patch testing. II. Proposed basic series of test substances for Scandinavian countries and general remarks on testing technique.


Besnier's prurigo (atopic dermatitis) in children.


Bone marrow studies in chronic leg ulcers.


Absence of deep leg veins in a case of Klippel-Trenaunay-Weber syndrome.


Acquired angioma.

Acquired angioma.


Thorium X in the treatment of nevus flammeus.


Investigation of patients suffering from generalized pruritus, with special references to systemic diseases.


Electron microscope observations of Kaposi's sarcoma.


Agranulocytosis due to acetosulfone (promacetin).


Toxic epidermal necrolysis and Stevens-Johnson's disease.


Reticulohistiocytosis (lipoid dermato-arthritis) of the skin and joints.


Immunoelectrophoretic analysis in acrodermatitis chronica atrophicans.


Cutaneous self-mutilation and potential self-destruction in a schizoid psychopath.


The inhibitory effect of dithranol (anthralin) on DNA synthesis.


Cellular changes in the psoriatic epidermis. IV. Studies on the submicroscopic organization of epidermal cells of long-term tissue cultures.


Glucose-6-phosphate dehydrogenase in erythrocytes of psoriatics.


Discoid lupus erythematosus. A study of sex and age at onset.


Urticaria changing to vitiligo provoked by electromyographic examination.


Gonorrhoea in 1964. Cases treated at the Department of Dermatology, Karoliska Sjukhuset.


The essence of gonorrhoea control. 3. The delineation of the male: female source ratio.


The gonococcal dermatitis syndrome. Demonstration of gonococci in skin lesions by immunofluorescence.


Genes and phenotypes in the Samaritan isolate.


From internal combustion to electricity.


Definitive treatment of 536 cases of hyperthyroidism with I-131 or surgery.


Effects of dextran infusion on the adhesiveness of human blood-platelets.


Cytomegalovirus mononucleosis with jaundice as presenting sign.


Anal carriage as the probable source of a streptococcal epidemic.


Survival of the foetus in a patient in acute renal failure.


Humoral basis of carcinoid flush.

Humoral basis of carcinoid flush.


Encephalitis of lethargica type in a mental hospital.


75th anniversary of the Lister Institute.


Urinary infection in the two sexes. Problems of aetiology.


Comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus. First report to the Medical Research Council by the working-party on the evaluation of different methods of therapy in carcinoma of the bronchus.


5-hydroxyindoles and kinins in the carcinoid and dumping syndromes.


Treatment of obesity by total fasting for up to 249 days.


Effect of penicillamine on human collagen and its possible application to treatment of scleroderma.


Nutrition and metabolic bone disease in old age.


The behavior of the basement membrane of skin and oral lesions in patients with lichen planus, erythema multiforme, lupus erythematosus, pemphigus vulgaris, benign mucous membrane pemphigoid, and epidermolysis bullosa.


Polypeptide chains of immunoglobulins from the smooth dogfish (Mustelus canis). The 17S and 7S immunoglobulins of the smooth dogfish, Mustelus canis, have been characterized with respect to molecular weights, chain structure, amino acid composition, and carbohydrate content. The 17S protein had a molecular weight of 982,000; that of the 7S protein was 198,000. Both proteins had similar amino acid compositions and a carbohydrate content of approximately 8 percent. Light and heavy chains from both immunoglobulins had molecular weights of 20,000 and 72,000 respectively. Apparently both immunoglobulins belong to the same class; this class resembles the gammaM-immunoglobulins of higher vertebrates.


A comparison of two different staining methods for evaluating corneal endothelial viability.


The effect of antibody to L-phenylalanine mustard conjugate on malignant cells selectively marked through "early inflammatory-like" vascular permeability.


Studies on the mechanism of template stability. I. The effect of actinomycin on the base composition and sedimentation of 32P-labeled RNA in rat liver.


Learning and memory in the immune response.


The influence of infection upon serum protein changes in severe burns.


Brucellosis among veterinary surgeons.

Brucellosis among veterinary surgeons.


Relation of variations in activation order to intraventricular pressures during premature beats.


Hypertensive angiopathy in familial chloride diarrhea.


Rapid staining of juxtaglomerular cell granules and renal tubular mitochondria for light microscopy.


The sympathetic chain in patients with diabetic and alcoholic polyneuropathy.


Effects of x-irradiation on the antigenic character of Agkistrodon piscivorus (cottonmouth moccasin) venom.


Narcotic blockade.

Narcotic blockade.


Solitary mast cell "tumor" of lung. Its place in the spectrum of mast cell disease.


Automating cancer cytodiagnosis by determining unbound acridine dye.


Metabolism of gammexane in flies, ticks and locusts.


The indirect fluorescent anti-body technic and the diagnosis of the connective tissue diseases.


Serum protein changes in Capillaria obsignata infections.


Apparatus and technique for cryosurgery of the prostate.


The clinical significance of increased activity of urinary lactic dehydrogenase.


Animal exposure chambers in air pollution studies.


Neocortical influence on the amygdala.

Neocortical influence on the amygdala.


Organization of somatic sensory mechanisms in the macaque cerebral cortex.


Cerebral somatosensory responses evoked during sleep in the cat.


Temperature changes in the rabbit brain during paradoxical sleep.


Electroencephalography in old age: dominant alpha pattern.


Headache and the EEG.

Headache and the EEG.


Prevention of air embolism in the decerebrate preparation.


Surgical immobilization of the eye and pupil, permitting stable photic stimulation of freely moving cats.


A computer technique for evaluation of recovery cycle of the H reflex in the abnormal movement disorders.


Studies on the transfer of human delayed-type hypersensitivity. I. Partial purification and characterization of two active components.


Effects of detergents on guinea pig skin. Histological studies after single exposure to anionic, cationic and non-ionic surfactants.


Studies of the mechanism of ultra-violet erythema formation. II. The effect of an increased and a reduced serotonin content of experimental animals.


Cellular localization and quantitation of tritiated antigen in mouse lymph nodes during early primary immune response.


Radiation necrosis and repair in rat fetal cerebral hemisphere.


Lactate dehydrogenase in urinary tract disease.


Inhibition of antibody production by ribonucleases.


The use of immunoadsorbents for the fractionation of rheumatoid factor and rabbit anti-human gamma-G antibodies.


Electrophoretic pattern of heat induced antibody-protein complexes.


New metabolites of imipramine.

New metabolites of imipramine.


Physician , heal thyself...

Physician , heal thyself...


Re-evaluation of the effect of estrogen on thyroid activity in the rat and its mechanism.


Evidence for heterogeneous turnover of iodine in rat thyroid glands.


Effect of a malignant tumor on thyroxine metabolism and thyroid function in the rat.


High and low energy states of cytochromes. I. In mitochondria.


High and low energy states of cytochromes. II. In submitochondrial particles.


High and low energy states of cytochromes. 3. In reactions with cations.


Phylogenetic origins of antibody structure. II. Immunoglobulins in the primary immune response of the bullfrog, Rana catesbiana. The anuran amphibian, Rana catesbiana, has been found to possess at least two kinds of immunoglobulins corresponding to gammaG- and gammaM-classes. These classes have the same chain structures as those of their counterparts in higher animal species. Light chains of both immunoglobulins had molecular weights of 20,000. Heavy chains of the gammaM-class had molecular weights of 72,100; those of the gammaG-class had molecular weights of 53,600. The carbohydrate content of the gammaG-immunoglobulin was 2.1%, and that of the gammaM-protein was 10.8%. The amino acid compositions of the immunoglobulins were generally similar to those of mammalian immunoglobulins. After a single injection of phage antigen (f2), the order of appearance of phage-neutralizing activity in the frog immunoglobulin classes was (a) gammaM-antibodies, and (b) gammaG-antibodies. The results of this and previous studies suggest that the gammaG-immunoglobulins emerged at some point in evolution between the elasmobranchs and the anuran amphibians.


Studies on Echinostomatidae (Trematoda) in Malaya. 13. Integumentary papillae on six species of Echinostome cercariae.


Quantitative variations in L chain types in guinea pig antihapten antibodies. In guinea pig purified antihapten antibodies, the proportion of molecules bearing the kappa- or lambda-type of L chains (K or L molecules) may diverge markedly from that found in normal gamma(2)-globulins. This has been evaluated by precipitation of I(131)-labeled antibody preparations using a specific anti-lambda-chain antiserum. Anti-DNP antibodies isolated 3 wk after immunization of guinea pigs with DNP(65)-BGG antibodies, contain less than 1% of L molecules, while in pipsyl antibodies, isolated from the sera of animals immunized with pipsyl-BGG, the proportion of L molecules is significantly greater than in normal gamma(2)-globulins. Anti-DNP antibodies produced against conjugates of this hapten with carriers other than BGG (BSA, OVA, or poly-L-lysine) or with BGG with a small number of DNP groups (DNP(10)-BGG) contained a greater proportion of lambda-chain bearing molecules than anti-DNP antibodies isolated from late sera of guinea pigs immunized with highly conjugated DNP(65)-BGG. An increased percentage of L molecules was detected in preparations of anti-DNP(65)-BGG antibodies isolated early (10 days), when compared to those isolated later during the course of immunization. However, the level of L molecules in all these anti-DNP antibody preparations was always considerably below that present in normal gamma(2)-globulin. The relative amounts of L molecules in distinct immunoglobulin families (gamma(1) and gamma(2)) in antibody preparations isolated from individual animals was remarkably similar.


Studies on Echinostomatidae (Trematoda) in Malaya. XIV. Body gland cells in cercariae of Echinostoma audyi Lie and Umathevy, and E. lindoense Sandground and Bonne.


Dilution dependent autoinhibition of agglutination in rheumatoid arthritis sera and rabbit anti-human gamma-G antisera.


Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus.


Immunoglobulin production in human leukemia cell lines.


Immunoglobulin classes of neutralizing antibody formed after human inoculation with soluble adenoviral antigens.


Inhibition of spleen cell DNA synthesis by autologous macrophages.


C'-1 fixation by human isoagglutinins: fixation of C'-1 by gamma-G and gamma-M but not by gamma-A antibody.


Gamma-M and gamma-G antibodies in mice: dissociation of the normal immunoglobulin sequence.


Refsum's disease: a disorder of lipid metabolism.


Hypertensive disease and cerebral oedema.


A safe and effective method of administering 5-fluorouracil to adrenalectomized patients.


Detection of venous thrombosis in the human by means of radioiodinated antifibrin-fibrinogen antibody.


A study of the effects of intra-arterial immunosuppressive drug therapy on canine renal allografts.


True hermaphrodism in a rhesus monkey.

True hermaphrodism in a rhesus monkey.


Histology and radioautography of induced benign enlargement of the mouse prostate.


Familial emphysema and alpha-1-antitrypsin deficiency.


Reactions of rheumatoid factor with natural human antibodies.


Increase of L-chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis.


Mechanisms of renal injury in systemic lupus erythematosus.


An in vitro system for studying hormonal induction of hepatic gluconeogenic enzymes.


Ultrastructure of basidiospores and mycelium of Lenzites saepiaria. Hyde, James M. (University of Mississippi Medical School, Jackson), and Charles H. Walkinshaw. Ultrastructure of basidiospores and mycelium of Lenzites saepiaria. J. Bacteriol. 92:1218-1227. 1966.-Ungerminated and germinated basidiospores and 2-day-old mycelial cultures of Lenzites saepiaria were similar in their fine structure. Fixation with glutaraldehyde, followed by osmium tetroxide, was far superior to permanganate. Cell organelles were seen in cytoplasm of spores and hyphae, and clamp connections were abundant in hyphal elements. Numerous lomasomes, vesicular bodies, and complex concentric membranes occurred in the cytoplasm and were often associated with the cell membrane or the dolipore membrane (parenthesome) of the septum. Endoplasmic reticulum was not found, but numerous ribosomes were seen; polyribosome groupings were frequently noted. The nucleus was bounded by a double membrane which contained few pores. Germinating spores exhibited one or more large osmiophilic bodies in association with a vacuole and membranous elements. Other than possessing a thin wall, the emerging germ tube was similar in structure to the parent spore.


Wheezing associated with respiratory tract infections in children. The role of specific infectious agents in allergic respiratory manifestations.


Immunofluorescent antibody studies of a murine leukemia virus. Brown, Eric R. (Northwestern University Medical School, Chicago, Ill.), Peter Buinauskas, and Steven O. Schwartz. Immunofluorescent antibody studies of a murine leukemia virus. J. Bacteriol. 92:978-982. 1966.-Correlation was close between in vitro complement fixation, immunodiffusion, and passive cutaneous anaphylaxis tests with the S-63 and GC murine leukemia viruses and immunofluorescence reactions with these viruses. When fluorescein-isothiocyanate-conjugated convalescent sera obtained from mice initially infected with S-63 leukemia virus were used, the reactive site was within the cytoplasm of the infected cell. By electron microscopic examination, virus particles were demonstrated in the same areas within the cells that exhibited specific fluorescence with the conjugates. Spleen and mesenteric nodes contained the most virus, whereas kidney tissues contained the least amount. Fluorescence was not observed within the nuclei of infected cells.


Antithyroid and antiadrenocortical activity of aminoglutethimide.


A simple method for estimating serum thyroxine concentration in thyroid disease and iodine-treated patients.


Correlation of structural and functional recovery from cirrhosis in rats treated with lipotropic diets.


A comparison of two principles for evaluating corneal endothelial viability.


Observations on the epidemiology of prostatic hyperplasia in Wales.


Anaplastic carcinoma of the thyroid with abnormal circulating iodoprotein: a case simulating subacute thyroiditis.


A simple electronic method for graphing EEG sleep patterns.


A technique for precision multi-channel evoked response averaging.


The use of 131-I-labelled albumin and amberlite IRA-400 in determination of protein-losing enteropathy.


Evolution of immunoglobulin polypeptide chains: carboxy-terminal of an IgM heavy chain. The dipeptide sequence at the carboxy-terminal of a heavy (micro) chain from a human macroglobulin ( IgM) is tyrosylcysteine, although the reverse sequence, cysteinyltyrosine, has not been rigorously excluded. The presence of cysteine at the carboxy-terminal was predicted from a recognition of the chemical homologies among the polypeptide chains of immunoglobulins, and their probable evolutionary origin.


Interactions between eye movements and the visually evoked response in the cat.


Oral contraceptives.

Oral contraceptives.


Gm(20), a new hereditary gamma globulin factor.


Gm and Inv studies of a Hokkaido population: evidence for a Gm2 allele in the Ainu.


Chemotherapy for advanced ovarian cancer.


Alpha-2-anti-trypsin activity and different trypsin substrates.


Colour reactions in chromatography.

Colour reactions in chromatography.


A comparison of dyes used for staining electrophoretically separated lipoprotein components.


Differential staining of ceruloplasmin as an aid to interpretation in immunoelectrophoresis.


The prevention of ageing in cells.

The prevention of ageing in cells.


Metronidazole in amoebic dysentery and amoebic liver abscess.


Faecal carriage of Pseudomonas aeruginosa in hospital patients. Possible spread from patient to patient.


Death from appendicitis and appendicectomy. An epidemiological survey.


Penicillamine for the treatment of Darier's disease and other disorders of keratin formation.


Absorption of macromolecules by neonatal intestine.


The long-term value of fasting in the treatment of obesity.


Plasma-testosterone levels in Kenyan men in relation to cancer of the nasopharynx.


Clinical differentiation between primary and metastatic brain tumours.


A comparison of infra-red and convective heating for newborn infants.


Accuracy of death certificates.

Accuracy of death certificates.


Brucellosis.

Brucellosis.


Better members.

Better members.


Dental erosion.

Dental erosion.


Obesity in childhood.

Obesity in childhood.


Alcohol and the pancreas.

Alcohol and the pancreas.


Steroid treatment of asthmatic children.


A method for the rapid determination of the number of patients to include in a controlled clinical trial.


Mental deficiency no ground for divorce.


Synthesis of alpha-2-AP (acute phase) globulin of rat serum by the liver.


Effect of antibiotics on some rumen and intestinal bacteria.


Electroencephalographic changes in children with migraine.


Thyroid hormone induction of alpha-glycerophosphate dehydrogenase in rats of different ages.


Antithyroid action in rats of small doses of some naturally occurring compounds.


Cirrhosis and prostatic neoplasms.

Cirrhosis and prostatic neoplasms.


Terminal patient care.

Terminal patient care.


The antagonism of the effects of compound 48-80 by protoveratrine A and piperacetazine.


Creating your own patient-education program with audio-visual materials.


Vascular volume changes following histamine release in the dog forelimb.


Hidden rheumatoid factors with specificity for native gamma globulins.


A case of congenital insensitivity to pain with neuropathic arthropathy.


Hexamethylentetramine-silver reaction for lysosomes.


Demonstration of sarcoplasmic reticulum of skeletal muscle by hematoxylin.


Increase in source of vaccinia immune globulins.


The relationship of juvenile hypothyroidism to chronic lymphocytic thyroiditis.


Studies on sarcoptic mange in camels (camelus dromedarius).


The frequencies of transferrin types in the population of Cracow (Poland).


The heptacarboxylic porphyrin of various types of porphyria and the melting-point curve of methyl esters of the 1 and 3 isomers.


Exhibit advances community nutrition education.


The effect of phenyramidol on the metabolism of bishydroxycoumarin.


On the possibility of selective staining of DNA and RNA using toluidine blue and related dyes.


Sequential estrogen and progestogen therapy. A clinical evaluation.


Studies on the staining of amyloid with Congo red.


Morphology of the cervix in women treated with synthetic progestins.


Variation in membrane structure as revealed by negative staining technique.


Modifications in the fluorescence microscopy technique as applied to identification of acid-fast bacilli in tissue and bacteriological material. The principles and techniques involved in fluorescence microscopy as related to the demonstration of acid-fast bacilli are discussed. The auramine-rhodamine staining method, for both tissue and bacteriological preparations, is described as well as the necessary equipment for both microscopy and photomicroscopy. Fluorescence staining is no more difficult nor time consuming than a Ziehl-Neelsen stain yet it is more effective in demonstrating acid-fast organisms.


Cytological features of anthrax spores phagocytized in vitro by rabbit alveolar macrophages.


Studies on sera from cases of myasthenia gravis, using the fluorescent antibody technique.


pH-changes in mercuric chloride solutions in contact with human and guinea pig skin, in vivo and in vitro.


Some attempts to influence the percutaneous absorption rate of sodium (22Na) and mercuric (203Hg) chlorides in the guinea pig. Effect of soap, alkyl aryl sulphonate, stripping, and pretreatment with distilled water and mercuric chloride.


Interaction between dithranol and nucleic acids. A possible mechanism for the effect of dithranol on psoriasis.


Histamine induced increase of basophil and eosinophil leukocytes in inflammatory exudates.


Dermatitis herpetiformis. Cases observed at the Dermatologic Clinic, Karolinska Sjukhuset, 1954--1963.


Psoriasis: aetiological aspects.

Psoriasis: aetiological aspects.


Ophthalmological changes in atopic dermatitis.


Myotonia atrophica and multiple calcifying epithelioma of Malherbe.


"Disappearance measurements", a method for studying percutaneous absorption of isotope-labelled compounds emitting gamma-rays.


Percutaneous absorption of sodium chromate (51Cr), cobaltous (58Co), and mercuric (203Hg) chlorides through excised human and guinea pig skin.


A non-specific effect of pollen distinguishable from the anaphylactic behaviour.


Motor behaviour of actively sensitized guinea-pigs during the anaphylactic reaction.


The behavioural pattern of the non-specific reaction to pollen in comparison with reactions to histamine, compound 48-80, serotonin and bradykinin.


Skin homograft survival in thyroidectomized and thyroxin treated guinea-pigs.


Partial inhibition of the lupus erythematosus cell phenomenon by dexamethasone.


Immunologic studies in pathologic conditions of the skin, with special reference to psoriasis.


Adhesive tape. Its bacteriostatic effect and its use in the treatment of ulcus cruris.


The latex-histamine test in skin diseases.


Microsporon canis--an actual cause of ringworm in Sweden.


Fluorescence microscopy of acantholytic cells in primordial vesicles in chronic forms of eczema.


Acute parapsoriasis with articular involvement. (Report of a case).


Congenital indifference to pain.

Congenital indifference to pain.


Diagnosis of experimental fungal corneal ulcers by fluorescent antibody techniques.


The temporal raphe of the human retina.

The temporal raphe of the human retina.


Hair loss in patients treated with carbimazole.


A study of individual neuro-muscular junctions in myotonia.


Motivational determinants of the "contingent negative variation".


The phasic relation of a component of alpha rhythm to fixation saccadic eye movements.


Some characteristics of stimulus-provoked alpha activity.


Behavioral and polygraphic study of "sleep" and "wakefulness" in chronic decerebrate cats.


Effects of anesthetics upon the EEG response to reticular stimulation. Patterns of slow synchrony.


Ontogenesis of paroxysmal cortical activity in foetal sheep.


Effects of an association between oxytocin and ACTH on the EEG and clinical evolution of some cerebral diseases.


The use of carbon electrodes for chronic cortical recording.


Histamine release in vivo during anaphylaxis in mice.


Regeneration and Hyper-regeneration of corneal nerves.


Some aspects of wound healing in the germfree animal.


The effects of polyamines on the melting of polyriboadenylic acid plus polyribouridylic acid complexes in a solution.


Landolt's club in the amphibian retina: a Golgi and electron microscope study.


Clinical, histochemical, and electron microscopic study of colonic histiocytosis.


Effect of central cooling in man on pituitary-thyroid function and growth hormone secretion.


Mucoprotein-containing histiocytes (muciphages) in the rectum. Mucoprotein-containing macrophages (muciphages) are a common finding in routine rectal biopsies, occurring in about 50% of cases. No correlation was found between their presence and the sex, age, and disease of the patient. They must be distinguished from the cells of Whipple's disease and from lipofuscin-containing macrophages. The origin of the mucoprotein is discussed and rectal epithelial mucin is considered a possible source.


Oral contraceptives.

Oral contraceptives.


Narcotic blockade--a medical technique for stopping heroin use by addicts.


Atypical bacteria in Whipple's disease.

Atypical bacteria in Whipple's disease.


Simplified procedure for determining sensitivities of mastitis causing organisms to antibacterial agents.


Pesticides--a dairy industry problem.

Pesticides--a dairy industry problem.


Ichthyosporidium sp. Schwartz, 1963, parasite of the fish leiostomus xanthurus, is a microsporidian.


Phytanic acid in Refsum's syndrome.

Phytanic acid in Refsum's syndrome.


Rules and regulations--Annual Award Committee.


Strike two.

Strike two.


Third molar impactions: need for removal and care.


Radiography in crown and bridge prosthodontics.


Accreditation program for dental laboratories.


NADSP supports proposal for children's dental health program.


Studies on the livetins of egg yolk. 3. Heterogeneity and immunoelectrophoretic behavior of beta-livetin.


Intracarotid amobarbital and metrazol test for the study of epileptiform discharges in man: a note on its technique.


Peptide maps of rabbit gamma-G-immunoglobulin heavy chains controlled by allelic genes.


Isoantibodies specific for myeloma gamma-G and gamma-H immunoglobulins of BALB-c mice.


Some comments on Höglund & Levin's electron micrographs of human serum proteins.


Dihydrostreptomycin and kanamycin ototoxicity. An experimental study by surface preparation technique.


Mechanism of antibody synthesis: size differences between mouse kappa chains. Structural analysis of immunoglobulin light chains has been carried out in an attempt to elucidate the genetic mechanisms involved in antibody synthesis. Analysis of two mouse kappa-chain proteins is almost complete. The differences are localized in one-half of the molecules, and do not reflect the operation of any one mutational mechanism. The peculiar character of the differences is discussed with reference to various theories of antibody formation. The finding that the two proteins differ in size is incompatible with certain proposed theories.


Granules and tubules in the cytoplasm of the sleeping sickness trypanosome: an electron microscope study.


A new ward for infectious skin conditions in the dermatologic clinic of the Karolinska Hospital, Stockholm.


Some immunological properties of guinea pig skin-saline suspension. I. Attempts to sensitize guinea pigs to homologous skin-suspension.


Some immunological properties of guinea pig skin-saline suspension. II. Rabbit dermatotoxic serum.


Spontaneous flare-up reactions induced by different amounts of 1,3-dinitro-4-chlorobenzene. Frequency of reactions, time of appearance and histology.


Routine patch testing 3. Frequency of contact allergy at six Scandinavian clinics.


Fluorescence microscopy of malignant melanomas in the Syrian golden hamster.


The effect of roentgen irradiation on the specific fluorescence of epidermal melanocytes.


High titer of Wassermann antibodies in a case of advanced myelomatosis.


Vitamin A in the treatment of maleformatio ectodermalis generalisata--"porcupine man".


Pigmentary disturbances due to drugs.

Pigmentary disturbances due to drugs.


A simple method for combined chemical and dermatological analysis of chemical mixtures by paper chromatography.


Tentative new classification of melanoma of the skin.


Parameters of hemostasis in Epidermolysis bullosa: absence of significant deviations from normal.


Influence of vehicles on the topical activity of fluorometholone.


Epidemic occurrence of trichophytosis among wrestlers.


Cytomorphologic analyses of smears from the male urethra in urethritis of gonococcal and non-gonococcal origin.