Regulation of 'malic' enzyme of Solanum tuberosum by metabolites. A purification of ;malic' enzyme from potato is described. The purified enzyme is specific for NADP and requires a bivalent cation for activity. At pH values below 7 the plot of rate versus malate concentration approximates to normal Michaelis-Menten kinetics. At pH values above 7 the plot of rate versus malate concentration is sigmoid. A number of dicarboxylic acids activate the enzyme and remove the sigmoidicity. The enzyme is inhibited by phosphate, triose phosphates and AMP. In general, effectors of the oxidative decarboxylation of malate behave in the same manner in the reductive carboxylation of pyruvate. The response of the enzyme to energy charge is reported and the physiological significance of the response to metabolites is discussed in relation to the proposed role of the enzyme in the control of pH.


Glucaric acid as an indicator of use of enzyme-inducing drugs.


Entamoeba histolytica. I. Aerobic metabolism.


Editorial: Prescribing habits of Australian doctors.


BCG in cancer immunotherapy: results obtained with various BCG preparations in a screening study for systemic adjuvants applicable to cancer immunoprophylaxis or immunotherapy.


The use of ritodrine in the treatment of premature labour.


Fluoridation--the alternative. (b) The pattern of dental caries.


Drug-induced capillaritis.

Drug-induced capillaritis.


Cryptorchidism in a family with Kallmann's syndrome.


Primary skin actinomycosis of the chest wall.


Macula-sparing monocular blackouts. Clinical and pathologic investigations of intermittent choroidal vascular insufficiency in a case of periarteritis nodosa.


Endogenous formation of carbon monoxide and methane at elevated pressure.


Diplococcus pneumoniae osteomyelitis in an infant with sickle cell anemia.


The development of bioluminescence in the ctenophore Mnemiopsis leidyi.


Banff Conference on Dental Auxiliaries. The winds of change.


The relationship between age and engagement in pleasant activities.


Letter: "Gamma-glutamyl cycle".

Letter: "Gamma-glutamyl cycle".


Hydroxylation of taurolithocholate by isolated human liver microsomes. I. Identification of metabolic product.


Proceedings: The pharmokinetics of rimiterol in asthmatic patients.


Proceedings: Preliminary observations on the human pharmacology of I.C.I. 66082 in normal volunteers.


Assessment of selective beta-adrenoceptor blockade in man. 1. Selective antagonism of the cardiac beta(1)-adrenoceptors has been studied in normal human volunteers.2. Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective beta-adrenoceptor blockade in 2 of 3 subjects studied.3. Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre.4. A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.


Proceedings: Inhibition of phenytoin metabolism by sulthiame.


The effects of carbon source on glutamate dehydrogenase activities in Aspergillus nidulans.


A comparative study of some convulsant substances as gamma-aminobutyric acid antagonists in the feline cerebral cortex. 1. By the use of microiontophoretic techniques, quantitative estimates were obtained of the depressant effects of gamma-aminobutyric acid (GABA) on single feline cortical neurones.2. Picrotoxin, bicuculline, strychnine, (+)-tubocurarine, penicillin and leptazol were also applied microiontophoretically to single neurones. Sequential GABA applications were made before, during and after the microiontophoresis of these substances and any effects on the time course of the GABA depression were measured as an estimate of antagonism or potentiation of GABA.3. (+)-Tubocurarine was found to be a potent GABA antagonist. Picrotoxin and bicuculline were rather less potent and strychnine and penicillin only weakly active as GABA antagonists. Leptazol appeared to be inactive against GABA depressions.4. In addition, bicuculline and strychnine were found to be capable of potentiating the depressant action of GABA. This property was not shared by the other substances studied.5. All the substances studied produced changes in neuronal firing rate that did not correlate with GABA antagonism.6. In conclusion, several potent convulsants have been shown to be capable of GABA antagonism. It is not yet clear that this effect, rather than a direct effect on neuronal excitability, is the prime mechanism behind their convulsant properties.


D-amino acid dehydrogenase: the enzyme of the first step of D-histidine and D-methionine racemization in Salmonella typhimurium.


Complementation studies of lethal alleles in the mouse causing deficiencies of glucose-6-phosphatase, tyrosine aminotransferase, and serine dehydratase. The pleiotropic effects of six radiation-induced lethal alleles at the albino locus in the mouse include deficiencies of various enzymes and of serum proteins. Closely correlated with the biochemical deficiencies are severe ultrastructural abnormalities of endoplasmic reticulum membranes and the Golgi apparatus in liver and kidney cells. Complementation studies led to the distinction of four different complementation groups among the six lethal alleles. The results are compatible with the interpretation that the six lethal alleles represent overlapping deletions of various sizes at and around the albino locus in the mouse, in a region concerned with the control of biochemical and structural differentiation.


The drug therapy of ulcerative colitis and of Crohn's disease.


Incomplete restoration of the bursa-dependent immune system after transplantation of allogeneic stem cells into immunodeficient chicks. Transplantation of allogeneic cells from bursa of Fabricius into cyclophosphamide-treated, immunodeficient chicks resulted in immunological tolerance to donor line skin grafts; graft-versus-host disease did not occur. Allogeneic bursal stem cells taken from 3-day-old donors induced restoration of bursal morphology, of antibody formation to Brucella abortus and of occurrence of pyroninophilic cells and immunoglobulin-bearing cells in the peripheral lymphoid tissues. Secondary response to sheep red blood cells and production of germinal centers were not restored. Transplantation of histocompatible bursal stem cells resulted in a complete reconstitution of the bursa-dependent lymphoid system, both in function and in morphology. Allogeneic postbursal stem cells taken from the bursa of 10-week-old donors had a reconstitutive effect only on the production of antibodies to Brucella. Transplanted stem cells maintained their functional potential in the allogeneic environment, since, when transferred back to histocompatible hosts, they displayed normal function. These findings indicate that a complete functional and morphological restoration of the bursa-dependent immune system cannot be achieved without identity of the donor and recipient at loci near to or identical with those determining the major histocompatibility antigens, even though graft-versus-host disease is avoided. This identity permits a full cooperation of the donor and host cells.


A comparison of the effects of antihistamines on platelet function.


The in vivo and in vitro effect of antihistamines on platelet aggregation.


Sympathectomy for hypertension.

Sympathectomy for hypertension.


Enhancement of ganglionic muscarinic activity by gallamine.


Some quantitative aspects of flight muscle damage in mosquitoes infected with filarial larvae.


A new parasite of mosquitoes, Reeismermis muspratte sp.nov. (Nematoda: Mermithidae), with notes on its life-cycle.


Conversion of carbon 4 of malate into products of the pentose cycle by isolated bundle sheath strands of Digitaria sanguinalis (L.) Scop. leaves.


Changes in hepatic fatty acid synthesis following glucagon injections in vivo.


The effect of sulthiame on disturbed behaviour in mentally subnormal patients.


Histogenesis and dependent glutamine synthetase inducibility in embryonic neural retina. Irreversible inhibition of differentiation by 5-bromodeoxyuridine.


Terbutaline: a preliminary report of its pharmacological properties and therapeutic efficacy in asthma.


Segmental aneuploidy and enzyme activity as a method for cytogenetic localization in drosophila melanogaster. A method of mapping genes which specify enzymes without the necessity of obtaining genetic variants has been explored. Three enzymes whose structural genes have known genetic positions were chosen to see if the relationship between gene dosage and enzyme activity could be used as a tool in cytological localization. Zw, the gene specifying G6PD, is located in the X chromosome region, 18D-18F. The structural gene for 6PGD, Pgd, maps in the X chromosome bands 2C1-2E1. Idh-NADP, the gene which specifies IDH-NADP, is found on the third chromosome, in bands 66B-67C.


Caries-inhibition by an amine fluoride dentifrice results after 6 years in children with low caries activity.


In vitro activity of levamisole on the infective larvae, microfilariae and adult worms of Breinlia Sergenti.


Role of amines in anaphylactic contraction of guinea pig isolated smooth muscle.


Uridine diphosphate galacturonate 4-epimerase from the blue-green alga Anabaena flos-aquae.


Steroid receptors and the mechanism of the specificity of glucocorticoid responsiveness of somatic cell hybrids between hepatoma tissue culture cells and mouse fibroblasts.


Mitochondrial omega-hydroxylation of cholesterol side chain.


Aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction in rat liver cells in culture.


Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis.


The role of antibiotics in the management of open fractures.


Ultrastructural study of effect of methionine sulfoximine on developing and adult rat cerebral cortex.


Studies on brain biopsies of patients with Huntington's chorea.


The occurrence in and actions of amino acids on isolated supra oral sphincter preparations of the sea anemone Actinia equina. 1. L-glutamic acid reversibly inhibits the contractions of isolated circular muscle preparations from different body regions of the sea anemone Actinia equina to electrical stimulation.2. L-glutamic acid does not cause inhibition of contraction by conversion to ammonia or gamma-amino-butyric acid, but appears to act on a glutamate receptor.3. It is postulated that in Actinia equina there is a receptor for glutamic acid whose structural requirements for activation are met by comparatively few analogues of glutamic acid. Of thirty-four analogues tested, only seven were active, most were less active, and only homocysteic acid had a greater activity than L-glutamic acid.4. Glutamic acid does not depress conduction of contraction in circular muscle preparations.5. The inhibition produced by L-glutamic acid does not appear to be conducted from one part of a preparation to another.6. Glutamic acid occurs in high concentrations in supra oral sphincter preparations of Actinia equina.7. Glutamic acid is released into sea water from sphincter preparations at rest and the amount released is increased by electrical stimulation of the preparation. However, many other amino acids are released at rest and following electrical stimulation, so that it is difficult to suggest that glutamic acid may be involved as a neurotransmitter in the sea anemone.


Letter: Estrogen effects on phenothiazine derivative blood levels.


Editorial: Drugs for anxiety.

Editorial: Drugs for anxiety.


Gamma glutamyl transpeptidase in normal pregnancy.


The properties of adrenal zona glomerulosa cells after purification by gravitational sedimentation.


Orchidectomy and the immune response. I. Effect of orchidectomy on lymphoid tissues of mice.


Orchidectomy and the immune response. II. Response of orchidectomized mice to antigens.


Microsomal enzyme activity in perfused rat liver.


Oxidative phosphorylation in Escherichia coli K12. An uncoupled mutant with altered membrane structure. 1. A new mutant strain (AN228) of Escherichia coli K12, unable to couple phosphorylation to electron transport, has been isolated. The mutant allele (unc-405), in strain AN228, was found to map near the uncA and uncB genes at about minute 74 on the E. coli genome. 2. A transductant strain (AN285) carrying the unc-405 allele is similar to the uncA and uncB mutants described previously in that it is unable to grow on succinate, gives a low aerobic yield on limiting concentrations of glucose, has a normal rate of electron transport, is unable to couple phosphorylation to electron transport, and lacks ATP-dependent transhydrogenase activity. 3. Strain AN285 (unc-405) is similar to an uncA mutant, but different from an uncB mutant, in that it is unable to grow anaerobically in a glucose-mineral-salts medium, and membrane preparations do not have Mg(2+)-stimulated adenosine triphosphatase activity. 4. Strain AN285 (unc-405) does not form an aggregate analogous to the membrane-bound Mg(2+)-stimulated adenosine triphosphatase aggregate found in normal cells. In this respect it differs from strain AN249 (uncA(-)), which forms an inactive membrane-bound Mg(2+)-stimulated adenosine triphosphatase aggregate.


Metabolic rate of phenacetin and of paracetamol in dogs before and after treatment with phenobarbital or skf 525 A.


Potentiating effect of cannabidiol on delta9-tetrahydrocannabinol-induced changes in hepatic enzymes.


Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs.


Northway virus: a new Bunyamwera group arbovirus from Alaska.


Haemodynamic effects of beta blockade in hypertrophic cardiomyopathy using Sectral (acebutolol; M and B 17803A).


The secretory antibody response. Anti-DNP antibodies induced by dinitrophenylated type 3 pneumococcus.


The assay of pneumococcal capsular polysaccharide by immunodiffusion.


The effect of emetine on myocardial catecholamine metabolism.


Effect of chronic intoxication with (+)-amphetamine on its concentration in liver and brain and on (14C) leucine incorporation into microsomal and cytoplasmic proteins of rat liver.


A comparative study of the effect of some centrally acting skeletal muscle relaxants in mice.


A study of the interaction of tetracycline with human serum lipoproteins and albumin.


Metabolism of nealbarbitone.

Metabolism of nealbarbitone.


Metabolism of heptabarbitone.

Metabolism of heptabarbitone.


Homogeneity of pharmaceutical dispersed systems.


Interaction of delta9-tetrahydrocannabinol and cannabidiol on intestinal motility in mice.


New inhibitor of acetylcholinesterase with preferential activity at nicotinic sites.


Effect of adrenergic substances on oxygen consumption of rat brain tissue.


Effect of chlorpromazine and some of its metabolites on the dopamine-sensitive adenylate cyclase of rat brain striatum.


The absorption of aspirin and paracetamol in patients with achlorhydria.


Effects of phenoxybenzamine, aceperone and clonidine on the level of 3-methoxy-4-hydroxyphenylglycol (MOPEG) in rat brain.


Anti-inflammatory activity of esters of phenylglycine.


The induction of ethanol dependence and the ethanol withdrawal syndrome: the effects of pyrazole.


A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors.


Ammonia assimilation in Saccharomyces cerevisiae as mediated by the two glutamate dehydrogenases. Evidence for the gdhA locus being a structural gene for the NADP-dependent glutamate dehydrogenase.


The effect of the carbon source on ammonium regulation in Aspergillus nidulans.


Reduced activation of epidermal phosphorylase in the lesions of psoriasis.


Action of Burimamide, a histamine antagonist, on acid secretion in vitro.


Differentiation of the glycogen body of the chick embryo. Studies on glucose-14 C incorporation, chorioallantoic grafting, histochemistry and electrophoresis.


A simplified MMPI form with reduced reading difficulty level.


Pharmacological reactivity of isolated ciliary arteries.


Bunolol metabolism by human and rat red blood cells and extrahepatic tissues.


Alpha adrenergic blocking agents: anti-nociceptive activity and enhancement of morphine-induced analgesia.


Diagnosis and treatment of epilepsy: overview and general principles.


Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo.


The role of macrophages, thymus- and bone marrow-derived cells in the graft-versus-host reaction.


The role of opsonization in antithymocyte globulin-induced suppression of graft-versus-host reaction in chick embryos.


Immune responses of rats deficient in thymus-derived lymphocytes to strong transplantation antigens (Ag-B). Graft-versus-host activity, allograft rejection, and the factor of immunization.


The value of respiratory tract bacteriology in pneumococcal pneumonia among Navajo Indians.


Gastrointestinal cancer syndromes. Gastrins, multiple endocrine adenomatosis, and the Zollinger-Ellison syndrome.


Pharmacology of M & B 18,706, a drug which selectively reduces decerebrate rigidity. 1 (+/-)-10-(3-Dimethylamino-2-methylpropyl)-2-valeroylphenothiazine hydrochloride (M & B 18,706) has been compared with dimethothiazine, chloropromazine, diazepam and baclofen for potency in reducing decerebrate rigidity in the cat and rat and for activity in causing ataxia or sedation.2 When given intravenously M & B 18,706 had seven times the potency of dimethothiazine and one-half the potency of chlorpromazine in reducing the rigidity of the intercollicular decerebrate cat. When administered orally M & B 18,706 and chlorpromazine were equi-potent in reducing rigidity but M & B 18,706 was less effective than chlorpromazine in producing ataxia in this species.3 In the rat, M & B 18,706 had one-quarter the potency of chlorpromazine for reducing decerebrate rigidity but had from 1/20th to 1/200th its potency in tests for sedative or tranquillizing activity.4 M & B 18,706, like dimethothiazine and chlorpromazine, had little effect on the rigidity of ischaemic decerebrate cats and failed to inhibit polysynaptic spinal reflexes.5 M & B 18,706 had intravenous potency comparable to chlorpromazine in reducing the pressor action of noradrenaline in the spinal cat.


The binding of (3H)-propylbenzilycholine mustard by longitudinal muscle strips from guinea-pig small intestine. 1 The synthesis of tritium labelled propylbenzilylcholine mustard ([(3)H]-PrBCM; N-2'-chloroethyl-N-[2'', 3''-(3)H(2)] propyl-2-aminoethyl benzilate) is described.2 The uptake by muscle strips was measured and shown to be considerably increased by previous immersion of the muscle in distilled water.3 A considerable part of the uptake is inhibited selectively by atropine, but not by nicotinic antagonists. A number of muscarinic agonists also inhibit uptake and their apparent affinity constants have been determined.4 The uptake by atropine-sensitive sites is temperature-insensitive, whereas the other sites are temperature-sensitive. Recovery is highly temperature-sensitive and there is good agreement between recovery of sensitivity to agonists and loss of radioactivity from the muscle.


Effects of lithium ions on electrical activity in sympathetic ganglia of the bullfrog. 1 The mode of action of lithium on electrical activity in the sympathetic ganglia of the bullfrog has been studied by recording extracellular and intracellular potential changes. Changes in nerve conduction and various types of synaptic transmission were studied when sodium ions in the external solution were totally replaced by equimolar concentrations of lithium ions and also when lithium ions were added to the external Ringer solution.2 Nerve conduction and nicotinic transmission in sympathetic ganglia were completely blocked in sodium-free sucrose solution, but were restored when the preparations were transferred to a sodium-free lithium solution.3 In the sodium-free lithium solution, the slow excitatory postsynaptic potential (e.p.s.p.) and muscarinic acetylcholine-depolarization were restored while the slow inhibitory postsynaptic potential (i.p.s.p.) and the muscarinic acetylcholine-hyperpolarization were not restored. Furthermore, the early after-discharges were accelerated and the inhibition of after-discharges was eliminated. These results support the hypothetical concept that the slow i.p.s.p. is generated by an activation of the electrogenic sodium pump.4 In the sodium-free lithium solution, restoration of nerve conduction and synaptic transmission were transient phenomena; both conduction and transmission were gradually blocked when preparations were soaked in the solution for long periods. The blockade appeared to be due to membrane depolarization.5 When lithium ions (20 mM) were added to the Ringer solution, nicotinic transmission was depressed. The slow e.p.s.p. was also depressed, but less so than the slow i.p.s.p. The early after-discharge was, however, accelerated; presumably due to the marked depression of the slow i.p.s.p. in this solution.6 Changes in synaptic transmission in Ringer solution containing lithium ions could be explained by membrane depolarization, a reduction of acetylcholine release and a depression of the electrogenic sodium pump.7 All results obtained in the present experiments could be explained by supposing that lithium ions are able to substitute for sodium ions in passive ionic membrane transport dependent on electrochemical energy but not in active ionic membrane transport dependent on metabolic energy.


Transmission to the longitudinal muscle of the guinea-pig vas deferens: The effect of pretreatment with guanethidine. 1 Tissue was taken from guinea-pigs that had been injected with guanethidine (100 mg/kg, i.p.) 24 h before they were killed, and from paired control animals.2 Pretreatment with guanethidine caused a significant, substantial, and sometimes complete reduction of the nerve-mediated contractions of the vas deferens. There were no significant changes in the responses of the ileum to stimulation of cholinergic nerves or of the distal colon to stimulation of intrinsic (non-adrenergic) inhibitory nerves. Responses of the vas deferens and ileum to acetylcholine were unchanged, but contractions of the vas deferens elicited by exogenous noradrenaline were enhanced.3 The nerve-mediated contractions of the vas deferens were restored by exposing it to (+)-amphetamine followed by noradrenaline in vitro.4 It is concluded that noradrenaline is the transmitter released from motor nerves to the longitudinal muscle of the guinea-pig vas deferens. Possible explanations for the ineffectiveness of receptor blocking agents in antagonizing transmission are discussed.


Separation of normals, neurotics and simulating malingerers on the MPI by means of discriminant function analysis.


A cross-validation of MMPI scales of aggression on male criminal criterion groups.


A comparative study of Excedrin P.M. and placebo.


Accuracy and generalizability of an automated MMPI interpretation system.


A comment on Garfield, Prager, and Bergin's evaluation of outcome in psychotherapy.


WAIS performance in unincarcerated groups of MMPI-defined sociopaths and normal controls.


Phylogeny of immune responsiveness in invertebrates.


Donor recipient pairing: an attempt to reconcile its theoretical power with its practical utility.


Control of pineal N-acetylserotonin by a beta adrenergic receptor.


Induction of hepatic microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent production of hydrogen peroxide by chronic prior treatment with ethanol.


Do cyclic nucleotides promote the trans-synaptic induction of tyrosine hydroxylase?


Method of solid tumour evaluation in the immunological experiment. II. A new easy complex method for evaluating resistance.


Avian rhabdomyosarcomas induced by Rous sarcoma virus.


Some biochemical studies on rats made hyper-reactive by bilateral electrolytic lesions in the anterior hypothalamus.


The actions of several psychoactive agents upon the muscarinic mechanisms in the superior cervical ganglion of the cat.


Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island.


Venezuelan equine encephalomyelitis in Florida: endemic virus circulation in native rodent populations of Everglades hammocks.


Infection and transmission of eastern equine encephalomyelitis virus with colonized Culiseta melanura (Coquillett).


Cardiogenic shock: therapeutic implications of altered myocardial energy balance.


Batken virus, a new arbovirus isolated from ticks and mosquitoes in Kirghiz S.S.R.


A quantitative study of the effects of isoproterenol and beta-adrenergic blocking agents in the rat uterus in situ.


The effects of anti-anginal drugs on AV-conduction in normal subjects.


A possible relationship between DT diaphorase and the aryl hydrocarbon hydroxylase system.


Selenium and hepatic microsomal hemoproteins.


Effect of anesthetics on the stability of oxyhemoglobin S.


The detection of differential beta-adrenoceptor blockade in the cat. 1. Tachycardia and bronchodilatation were produced by intravenous dimethylphenylpiperazinium iodide (DMPP) in the spinal or pithed cat. Responses other than those involving beta-adrenoceptors were minimized by appropriate blocking agents.2. With intact adrenals, both the tachycardia and bronchodilatation with 10 mug/kg DMPP were equal to those with 1 mug/kg adrenaline.3. After adrenalectomy, tachycardia with 100 mug/kg DMPP was equal to that with 1.5 mug/kg adrenaline, but the bronchodilatation was equal to that with only 0.3 mug/kg. This difference may reflect the relative activity of the sympathetic supply to the organs.4. After adrenalectomy, propranolol was 3 times as effective against bronchodilatation due to DMPP as against tachycardia. Practolol was inactive against bronchodilatation.5. With intact adrenals, propranolol reduced both tachycardia and bronchodilatation due to DMPP equally. Propranolol also antagonized equally both effects of adrenaline in the pithed cat after adrenalectomy.6. In the spinal cat, propranolol caused bradycardia and bronchoconstriction that persisted after adrenalectomy or pithing. It was reduced by pempidine and guanethidine and is attributed to spontaneous adrenergic neuronal activity.7. The Appendix describes a device for cycle-by-cycle spirometry and correction for zero drift of a micromanometer, used in this study for the continuous recording of bronchial resistance.


Further studies regarding the structure activity relationships of beta-adrenoceptor antagonists. 1. The ortho (M66,527) and para (M66,368) analogues of 1-t-butylamino-3-(methoxyphenoxy)-2-propanol and para substituted tertiary butylphenoxy-1-N-isopropylamine-3 propanol-2 oxalate acid (L8429) were tested in dogs for their beta-adrenoceptor blocking activity.2. M66,527, which contains a methoxy group in the ortho position of the benzene ring, was found to be comparable to propranolol in blocking cardiac and peripheral vascular responses to isoprenaline. Like propranolol, M66,527 was more potent on peripheral receptors.3. Transference of the methoxy group to the para position (M66,368) reduced the overall potency; however, this compound was found to be relatively cardioselective in that it was 2 to 3.6 times more active in blocking cardiac responses to isoprenaline.4. The cardioselective properties of the short chain para methoxy substituent were less than those reported for compounds with longer para substitutions (i.e. practolol, para oxprenolol and para alprenolol).5. L8429, with a tertiary butyl group in the para position, was a weak beta-adrenoceptor antagonist without cardioselective properties. A longer, less bulky n-butyl group may provide for a more potent and selective antagonist.6. The results support the view that the size and site of the substituent on the benzene ring may be of importance in determining the cardioselective potency of beta-adrenoceptor antagonists.


Glucose-6-phosphate dehydrogenase in the blood of psoriatics, and the effects of methotrexate.


Enzymes of glucose metabolism in liver of subjects with adult-onset diabetes.


Multilateral agencies and world population growth. The world plan of action: is China already setting the pace?


The role of the World Health Organization in health related aspects of family planning. The World Health Organization works in health related aspects of human reproduction, family planning, and population dynamics with an emphasis on the integration of family planning services with basic health services and the strengthening of  those services.  It is also involved in research, training, health and medical education, and promotion of nursing, midwifery and health auxiliaries.  WHO is the central agency responsible for the coordination of internal assistance to family planning programs and it aids in there evaluation.


Altered growth hormone homeostasis during acute bacterial sepsis in the rhesus monkey.


Acetylsalicylsalicylic acid: a potentially immunogenic impurity in acetylsalicylic acid.


Plasma and cerebrospinal fluid concentrations of pentazocine in patients: assay by mass fragmentography.


Functional significance of synthesis of noradrenaline in adrenergic nerves of rat salivary glands.


The involvement of dopaminergic systems with the stereotyped behaviour patterns induced by methylphenidate.


The correlation between the in vitro and in vivo availability of salicylic acid for membrane transfer from polysorbate 20 solutions.


The effect of urea on the solubility of methyl p-hydroxybenzoate in aqueous sodium chloride solutions.


An infrared spectrophotometric study of the compaction mechanism of potassium bromide.


X-ray analysis of disodium cromoglycate.


Some benzhydryl derivatives as central dopamine receptor stimulating agents.


Induction of rhythmicity in a normally quiescent smooth muscle.


Comparative potencies of dopamine and noradrenaline on the rabbit ear artery.


Appearance in cat cerebrospinal fluid of radiolabelled metabolites following intraventricular injection of (3H)choline.


Resistance of intestinal alpha-adrenoceptors to cold storage.


Effect of 2,5-dimethoxy-4-methylamphetamine on heart and smooth muscle contraction.


Non-specific actions of dihydroxylated tryptamines in the central nervous system of the rat.


The dependence of imipramine-induced sedation upon central 5-hydroxytryptamine-like activity in the frog.


Daily susceptibility variations to the morphine-induced hyperactivity of rats.


A possible interaction of quipazine with central dopamine structures.


Stability of rolitetracycline in aqueous solution.


The polarographic and spectral behaviour of some 1,4-benzodiazepine metabolites: application to differentiation of mixtures.


Congenitally uncoiled epididymis in a cryptorchid testicle.


Abdominal musculature deficiency syndrome prune belly.


Development of tolerance in rats to the hypothermic effects of D-amphetamine and apomorphine.


Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism.


Editorial: Symposium on dialysis.

Editorial: Symposium on dialysis.


Coronary vasomotor responses to cardiac sympathetic nerve stimulation after adrenergic beta-receptor in dogs.


Acebutolol in cardiac arrhythmias.

Acebutolol in cardiac arrhythmias.


Prune belly syndrome.

Prune belly syndrome.


How learning conditions in early childhood--including mass media--relate to aggression in late adolescence.


Natural abundance 13C nuclear magnetic resonance spectra of nicotinamide adenine dinucleotide and related nucleotides.


The action of nitrous acid on C-teichoic acid (C-substance) from the walls of Diplococcus pneumoniae. 1. C-teichoic acid (C-substance) from the walls of Diplococcus pneumoniae contained free amino groups accessible to attack by nitrous acid. Treatment with nitrous acid, followed by reduction with borohydride and hydrolysis with acid, gave ribitol, glucitol and their respective phosphates. 2. Hydrolysis of the polymer with alkali followed by treatment of products with nitrous acid yielded glucose. 3. When alkali hydrolysis was followed by treatment with a phosphomonoesterase, nitrous acid degradation of C-substance yielded glucose and a disaccharide identified as 2-O-(N-acetylgalactosaminyl)-d-ribitol. 4. A partial structure for C-teichoic acid was deduced in which the order of the constituent residues and the position of phosphodiester linkages were established.


Production, estimation, and reproduction of time intervals during inhalation of a general anesthetic in man.


Effects of some hypocholesterolemic agents on hepatic ulrastructure and microbody enzymes.


Effects of beta adrenergic blockade on plasma catecholamines in exercise.


Human marrow transplantation--current status.


Scanning electron microscopy of the sensory surface of the tentacles of sea anemones and corals.


Stimulation of enzyme synthesis and inhibition of DNA synthesis and growth rate by cyclic AMP derivatives in cultured hepatoma cells.


Inhibition of amino acid transaminases by L-cycloserine.


Food and light as separate entrainment signals for rat liver enzymes.


Marrow transplantation for aplastic anemia and acute leukemia.


Estrogen-induced uterine enzymes in the control of estradiol action.


Editorial: WFMH is alive and well and living in Jamaica.


Modification of the responsiveness of F1 hybrid rats to lymphocytes from parental strain rats.


Allylglycine, and inhibitor of the uptake of L-leucine and L-proline in rat brain slices.


Interaction of apomorphine, neuroleptics and stimulants with alpha-methyl-m-tyramine, a false dopaminergic transmitter.


The purification of Portuguese man-of-war nematocyst toxins by gel diffusion.


The role of dihydropyrimidinase in the metabolism of some hydantoin and succinimide drugs.


Present status of underwater medicine. Review of some challenging problems.


Metabolism of the herbicide methozole (2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidine-3,5-dione) in rats.


The metabolism of betahistine in the rat.


Urinary metabolites of N-methyl-alpha-methyl-alpha-phenysuccinimide (methsuximide) in the dog.


Cold exposure: effects on hepatic tryptophan oxygenase and tyrosine aminotransferase, plasma tryptophan and tyrosine, and brain monoamines.


Dihydrodigoxin: a common metabolite of digoxin in man.


Studies on the metabolism and pharmacology of alpha-((2-pyridylamino)methyl)benzyl alcohol hydrochloride (phenyramidol hydrochloride) in rodents.


Studies on the physiologic disposition and activity of phenylpropanolamines in the mouse.


Effect of the hypolipidemic drug nafenopin (2-methyl-2-(p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy)propionic acid; TPIA; SU-13,437), on the hepatic disposition of foreign compounds in the rat.


The aniline hydroxylase and nitroreductase activities of partially purified cytochromes P-450 and P-420,  and cytochrome b5 solubilized from rabbit hepatic microsomes.


Needle method of testicular biopsy.

Needle method of testicular biopsy.


Autoradiographic study on the recirculating lymphocytes in rats undergoing graft-versus-host reaction.


Reduced output of thoracic duct cells in rats affected by graft-versus-host reaction.


Identification and activity of the hydroxy metabolite that accumulates in the plasma of humans intoxicated with glutethimide.


Hepatic uptake, metabolism, and biliary excretion of 7,12-dimethylbenzanthracene in the rat.


Field studies on the feeding habits of mosquitoes in the highveld region of South Africa.


Pharmacological study of antihistaminic principle(s) in the Rana tigrina tissues.


Effect of ten beta-adrenoceptor blocking agents on spontaneous motility and pentobarbital-induced anaesthesia in mice.


Effect of pyrazole on rat liver catalase.


Studies on local anaesthetic and antiarrhythmic actions of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCI (USVC-6524), a new beta-adrenoceptor antagonist.


Histochemical studies of the skin in recurrent erysipelas.


Proceedings: SGOT and CPK isoenzymes in clinical medicine.


Proceedings: Advances in clinical enzymology.


Proceedings: Gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing anticonvulsant drugs.


Proceedings: Specific determination of glucose-6-phosphate dehydrogenase in erythrocytes using the LKB 8600: extraction procedures, stability studies, and reference values calculated per mean erythrocyte.


Sir Rickard Christophera: the first 100 years. A biographical note.


A review of studies on the immunization against the pathogenic protozoan diseases of man.


Parasitic protozoa of the blood of rodents. II. Haemogregarines, malaria parasites and piroplasms of rodents: an annotated checklist and host index.


The occurrence of intracellular rickettsia-like organisms in the tsetse flies, Glossina morsitans, G. fuscipes, G. brevipalpis and G. pallidipes.


Amino acid analyses of haemolymph of Glossina morsitans morsitans (Westwood).


Tick-host relationships. 3. The effect of photoperiodic pre-conditioning on the circadian rhythm of "drop-off" of engorged pre-imaginal stages of the tick Hyalomma excavatum (Koch, 1844) from the gerbil--Meriones tristrami.


Proceedings: 85. Relationship between metals and enzymes in canine pancreatic juice.


Indirect assessment of myocardial oxygen consumption in the evaluation of mechanisms and therapy of angina pectoris.


Medical screening of patients with coronary artery disease. Criteria for entrance into exercise conditioning programs.


Comparison of media for detection of fungi on spacecraft. Five media, including Trypticase soy agar (TSA; BBL) pour plates, spread plates of TSA, Mycophil agar with chloromycetin, Mycophil agar with chloromycetin and Actidione, and cornmeal agar with chloromycetin were quantitatively and qualitatively compared for the detection of fungi on spacecraft. Cornmeal agar with chloromycetin yielded the highest number of fungal colonies, although not always significantly higher than Mycophil agar with chloromycetin or TSA spread plates. Cornmeal agar with chloromycetin also gave the best qualitative representation of fungi on the spacecraft, recovering 68% of the genera found from all media. This medium yielded 10 times the number of fungal colonies and 3 times the number of genera found on TSA pour plates as currently used for spacecraft assay.


Interactions of quazodine with cardiotoxic doses of ouabain in the anesthetized dog.


The effect of certain tranquilisers, chlorpromazine metabolites and diethyldithiocarbamate on tissue amphetamine levels in the rat.


Pulmonary and systemic circulatory effects of midodrine, a new sympathomimetic, and its metabolite, ST 1059.


Antiarrhythmic and general cardiovascular activity of the N,N-dimethylquaternary ammonium derivative of bunolol.


Interaction of phenothiazine derivatives with human ceruloplasmin.


Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD).


Microsomal epoxidation of cis-stilbene: decrease in epoxidase activity related to lipid peroxidation.


Electroencephalographic investigations during evaluation of the antiepileptic agent sulthiame.


Role of the sympathetic innervation of the pacinian corpuscle. An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the pacinian corpuscle. The monoamine oxidase inhibitors iproniazid and phenelzine are capable of protecting the transducer from the blocking effects of reserpine. It is concluded that the presence of norepinephrine, as maintained by sympathetic tonus, is required for the afferent nerve terminal of the pacinian corpuscle to be mechanosensitive.


Traumatized teeth of children. Emergency and intermediate restorative treatment.


Glucagon and the insulin: glucagon ratio in severe trauma.


Editorial: Hypoglycaemia and personality.


Development of filarial parasites in mosquitos in north-east Tanzania. Natural populations of 6 species of mosquito-Anopheles tenebrosus, Taeniorynchus (Mansonioides) africanus, Taeniorynchus (Mansonioides) uniformis, Anopheles coustani, Anopheles ziemanni, and Anopheles pharoensis-were examined for filarial parasites. Infective stages of Dirofilaria immitis were found in the first 3 of these species, which are therefore considered vectors. Laboratory studies to see whether or not any of the 6 could potentially transmit Wucheria bancrofti showed only A. tenebrosus to be capable of producing the infective stage.


Bacterial growth in vivo. An important determinant of the pulmonary clearance of Diplococcus pneumoniae in rats. Lung clearance of Diplococcus pneumoniae was markedly reduced in rats with acute hemorrhagic pulmonary edema produced by instillation of hydrochloric acid. Bacterial clearance was enhanced in both control and acid-instilled animals by pretreatment with a bacteriostatic antibiotic, tetracycline, 30 mg/kg. From these data the contributions of bacterial multiplication and bacterial elimination to net lung bacterial clearance were estimated. In control animals the constant for exponential bacterial elimination was -1.4283 (fractional clearance = 76% per h), and the doubling time for the pneumococcus was 170 min. In acid-instilled rats the elimination constant was -0.5336 (fractional clearance = 41% per h), and the doubling time of the pneumococcus was 47 min, approximating the doubling time of 42 min observed with pneumococci grown in broth. These results indicate that, in the case of pneumococci, both bacterial elimination and bacterial growth contribute to lung bacterial clearance in normal animals as well as animals with damaged lungs. In the present study changes in both parameters were required to explain the observed results in acid-instilled animals. The pulmonary pathogenicity of some bacterial species may be determined by their capacity for growth in the lung, since infection of the lung occurs when bacterial multiplication exceeds the rate of elimination of viable organisms.


Complete restoration of bursa-dependent immune system after transplantation of semiallogeneic stem cells into immunodeficient chicks. For transplantation of semiallogeneic bursal stem cells into cyclophosphamide-treated 3-day old chicks, two lines of chickens homozygous at the major histocompatibility locus and their F(1) hybrids were used in reciprocal combinations. The semiallogeneic transplantations resulted in a complete restoration of antibody formation to sheep red blood cells (SRBC) and Brucella, of microscopic morphology of bursa fabricii, and of germinal center formation in the spleen. In contrast, allogeneic bursal stem cells were not effective in restoring secondary response to SRBC and germinal center formation, while they were able to reconstitute anti-Brucella responses and bursal morphology. These findings indicate an effective cooperation of donor and host cells leading to a complete restoration of the bursa-dependent lymphoid system, when the donor and recipient share at least one haplotype determining the major histocompatibility antigen complex.


Quantitative alterations in the ecology of the oropharyngeal microflora subsequent to tonsillectomy and adenoidectomy.


To the members of the International Commission on Trichinellosis (ICT).


Spermatozoan vesicle loss during penetration of the female gonangium in the hydroid. Campanularia flexuosa.


Functional units in the labellar chemosensory hairs of the mosquito Culiseta inornata (Williston).


The sorption of benzocaine from aqueous solution by nylon 6 powder.


New curare-like agents.

New curare-like agents.


Butobarbitone metabolism in man: identification of 3'-ketobutobarbitone.


In vivo estimation of tyrosine hydroxylation in the dopaminergic terminals of the rat neostriatum.


Role of the central autonomic nervous system in the hypotension and bradycardia induced by (-)-delta 9-trans-tetrahydrocannabinol.


Bioassay of vasopressin on the rabbit isolated urinary bladder.


An assay for phenylephrine applicable to stability studies.


Infrared spectroscopy using attenuated total reflection.


Metabolism of chlorphentermine and phentermine in man to yield hydroxylamino, C-nitroso- and nitro-compounds.


A technique for repeated blood sampling with transfusion in the conscious rat.


Effect of chloroquine on histamine-induced bronchial asthma in the guinea-pig.


Paradoxical thermoregulatory behaviour in rats induced by (plus)-amphetamine: blockade by alpha-adrenoceptor or dopamine receptor blocking agents.


Letter: The calculation of the tensile strength of tablets.


Letter: Do adrenergic fibres have muscarinic inhibitory receptors?


The effects of burimamide on gastric acid secretion and gastric mucosal blood flow in the anaesthetized cat.


Influence of age on ortho-hydroxyphenylacetic acid excretion in phenylketonuria and its genetic variants.


Agranulocytosis associated with sulphasalazine therapy.


Effect of phenobarbital administration on liver and plasma gamma-glutamyl-transpeptidase: clinical and experimental investigations.


Effect of calcitonin on gastric and pancreatic secretion and peptic ulcer formation in cats.


Familial occurrence of Noonan syndrome.

Familial occurrence of Noonan syndrome.


Efficacy of a "mixed bacterial vaccine" in prophylaxis of acute respiratory infections: possible role of interferon.


Metabolic effects of acetaldehyde in the intact rat brain cortex and its subcellular fractions.


Aspects of inorganic nitrogen assimilation in yeasts.


The bronchodilator activity of AY-22093, a prostanoic acid derivative.


Blockade of cardiac histamine receptors by promethazine.


The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.


In quest of emesis: fact, fable, and fancy.


Hospital management of acute iron ingestion.


Methemoglobin reductase deficiency in a dog.


Reactions between certain strains of pneumococci and Fc of IgG.


Regulation of the antibody response to type 3 pneumococcal polysaccharide. IV. Role of suppressor T cells in the development of low-dose paralysis.


Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.


Physical and immunologic properties of pneumococcal capsular polysaccharide produced during human infection.


Studies on iron loading of rat liver lysosomes. Effects on the liver and distribution and fate of iron.


An autopsy case of Behçet's syndrome associated with pulmonary arteritis and tuberculosis.


Anesthetic experience with total hip replacement.


The personal doctor--a luxury or a necessity?


A glimpse of medicine in China.

A glimpse of medicine in China.


Systemic granulomatous reaction to salicylazosulfapyridine (Azulfidine) in a patient with Crohn's disease.


An arteritis with special reference to polymyalgia arteritica.


7th European Conference on Microcirculation. International conference, Aberdeen 1972. I. Methodology in microcirculation.


Enzymatic production of urocanic acid by Achromobacter liquidum. To develop an efficient method for the production of urocanic acid, optimal conditions for the production of microbial L-histidine ammonia lyase and for the conversion of L-histidine to urocanic acid by this enzyme were studied. A number of microorganisms were screened to test their ability to form and accumulate urocanic acid from L-histidine. Achromobacter liquidum was selected as the best organism. With this organism, enzyme activity as high as 2.0 units/ml could be produced by a shaking culture at 30 C in a medium containing glucose, urea, potassium phosphate, L-histidine, yeast extract, peptone, and inorganic salts. Appropriate addition of a surface-active agent to the reaction mixture shortened the time required for the conversion. A large amount of L-histidine was converted stoichiometrically to urocanic acid in 48 h at 40 C. Accumulated urocanic acid was readily isolated in pure form by ordinary procedures with isoelectric precipitation. Yields of isolated urocanic acid of over 92% from L-histidine were easily attainable. When the culture of Achromobacter liquidum was added to DL-histidine, D-histidine and urocanic acid were simultaneously obtained in high yields.


Mathematical estimation on the level of microbial contamination on spacecraft surfaces by volumetric air sampling. Microbiological sampling methods presently used for enumeration of microorganisms on spacecraft surfaces require contact with easily damaged components. Estimation of viable particles on surfaces using air sampling methods in conjunction with a mathematical model would be desirable. Parameters necessary for the mathematical model are the effect of angled surfaces on viable particle collection and the number of viable cells per viable particle. Deposition of viable particles on angled surfaces closely followed a cosine function, and the number of viable cells per viable particle was consistent with a Poisson distribution. Other parameters considered by the mathematical model included deposition rate and fractional removal per unit time. A close nonlinear correlation between volumetric air sampling and airborne fallout on surfaces was established with all fallout data points falling within the 95% confidence limits as determined by the mathematical model.


Lichen planus. A case presentation.

Lichen planus. A case presentation.


Damage to teeth during the administration of general anaesthesia.


Neurohumoral control of blood coagulation: adrenergic stimulation and spleen in the control of factor VIII plasma level.


Neurohumoral control of blood coagulation: participation of the adrenal glands.


Bilaterally cryptorchid stallion with female karyotype.


Comparative enzymatic development in chick embryonic brain areas.


We must write next chapter of anti-substitution saga.


Forearm replantation. A case report of a two-year follow-up.


Hemofiltration for Schistosomiasis japonicum.


Drugs in the management of learning and behavior disorders in school children.


"Snap, crackle, and pop".

"Snap, crackle, and pop".


The view box.

The view box.


EKG of the month.

EKG of the month.


Angiosarcoma of the liver.

Angiosarcoma of the liver.


Simple fluoroscopic studies for upper airway problems.


Surgical grand rounds. Parietal cell vagotomy.


Prescribing physical therapy.

Prescribing physical therapy.


Treatment of children with burns.

Treatment of children with burns.


Editorial: Medicine in trouble.

Editorial: Medicine in trouble.


Treatment of anxiety neurosis by alpha and beta adrenergic blocking agents.


Simultaneous measurement of eight foreign gases in blood by gas chromatography.


Physician's assistant program: development and current status at WSU.


Jack of all trades--master of none.

Jack of all trades--master of none.


A specialty for associate-degree nursing program graduates: increasing neophyte competency and confidence.


Expectations of the associate-degree graduate: a director of nursing's point of view.


Associate degree: education for what?

Associate degree: education for what?


Editorial: Issues in associate-degree education in nursing.


For everything there is a time.

For everything there is a time.


Associate-degree graduates: generalists or specialists?


Pharmacology of the central nervous system.


The autonomic nervous system.

The autonomic nervous system.


Regional physiology of the nervous system.


Lymphocyte and polymorphonuclear enzymes in stress. IV. Changes associated with an acute bacterial infection with Diplococcus pneumoniae.


Organic solvent extraction of liver microsomal lipid. I. The requirement of lipid for 3,4-benzpyrene hydroxylase.


Studies in occupational dentistry. II. Dental hazards affecting battery formation workers.


Effect of beta-adrenergic blocking compounds on tissue catecholamine levels.


Bronchodilator effects of sympathomimetic amines given singly and in combination.


Studies on the regulation of glutathione level in rat liver.


Hormonal regulation of tyrosine transaminase synthesis in isolated, rat liver perfused with synthetic medium.


The regulation of glutamine synthesis in the food yeast Candida utilis: the purification and subunit structure of glutamine synthetase and aspects of enzyme deactivation.


The colony-forming cell in the normal and leukemia human host: responses to streptovaricin and rifamycin SV.


Effects of an epoxide hydrase inhibitor on in vivo binding of polycyclic hydrocarbons to DNA and on skin carcinogenesis.


Effect of pyridoxine deficiency on tyrosine transaminase activity and growth of four Morris hepatomas.


Letter: Untreatable pain: the three-time losers.


Elevated immunoglobulin E in infantile polyarteritis nodosa.


Identification of S-carboxymethyl-thiopyruvate as the product of oxidative deamination of S-carboxymethyl-cysteine.


Pneumococcal meningitis in mother and neonate.


Letter: Cryptorchidism in siblings.

Letter: Cryptorchidism in siblings.


The second-class doctor and the medical assistant in South Africa.


The oxidative desaturation of unsaturated fatty acids in animals.


Rapid purification of glucose 6-phosphate dehydrogenase from human erythrocytes by means of affinity chromatography.


Aryl hydrocarcon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo(a)pyrene-resistant cells.


Enzymatic reduction of D-biotin-d-sulfoxide with cell-free extracts of Escherichia coli.


Oxidative phosphorylation and respiratory control in lysolecithin treated electron transport particles.


Low temperature electron paramagnetic resonance studies on iron-sulfur centers in cardiac NADH dehydrogenase.


NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity.


The role of messenger RNA in tyrosine aminotransferase superinduction: effects of camptothecin on hepatoma cells in culture.


Tyrosine hydroxylase activity: regional and subcellular distribution in the brain.


Effect of metiamide, a histamine H2-receptor antagonist, on mucosal blood flow and serum gastrin level.


Adrenoceptors and salt and water movement in epithelia.


Foot and mouth disease O1-antibody levels in Egyptian cattle.


Characterization of papovavirus-and picornavirus-like particles in permanent pig kidney cell lines.


Conversion of phage types of S. typhi-murium due to different R-plasmids.


Phage typing of S. typhi murium in the Netherlands. 1. The phage typing system.


Phage typing of S. typhi murium in the Netherlands. 2. Frequency distributions of S. typhi murium phage types in the Netherlands during 1971 and 1972.


The action of phospholipase A on the common Enterobacteriaceae antigen of the Kunin-type.


Release of the dipicolinic acid (DPA) from spores of Bacillus stearothermophilus, B. megaterium and B. anthracis in presence of dyes.


Growth and extracellular lipids of certain pathogenic fungi in presence of different concentrations of amino acids.


Heat inactivation and determination of serum gamma-glutamyltranspeptidase as a profile in identification of human alkaline phosphatase.


Letter: Polyarteritis after influenza vaccination.


Cellular energy metabolism during fetal development. V. Fatty acid synthesis by the developing heart.


Induction of tyrosine aminotransferase by triamcinolone during rat liver development in vitro.


Circulatory support with intravenous microdrip drug therapy.


The physician assistant: one solution to the health care crisis.


Studies on the eyes of catfishes with special reference to the tapetum lucidum.


Reappearance of specific colour patterns after nerve regeneration in Octopus.


Studies on the structure and function of the mammalian testis. IV. Steroid metabolism in vitro by isolated interstitium and seminiferous tubules of rat testis after heat sterilization.


The arrangement of myosin on the surface of paramyosin filaments in the white adductor muscle of Crassostrea angulata.


A D-periodic narrow filament in collagen.


The occurrence of carnitine and glycerylphosphorylcholine in the octopus spermatophore.


Bile acids. XLI. Hepatic microsomal 12 alpha-hydroxylation of allochenodeoxycholate to allocholate.


Diagnosis of alcoholism. Factors of drinking, background and current conditions in alcoholics.


Gamma glutamyl transpeptidase in chronic obstructive pulmonary disease.


Ethanol and acetaldehyde effects on metabolism and binding of biogenic amines.


Thymus dependency of periarteritis nodosa in DOCA and salt treated mice.


Graft-versus-host disease in rats after donor treatment with cyclophosphamide and spleen cells of host origin.


Reversal of verapamil-, dichloroisoproterenol-, and propranolol-induced cardiac failure by histamine.


An investigation of the ionic calcium assay based on the jellyfish protein aequorin.


Strabismus.

Strabismus.


Guinea-pig atrial and pulmonary beta-adrenoceptors.


High molecular weight isoenzymes of alkaline phosphatase in human serum. Demonstration by cellulose acetate electrophoresis and physico-chemical characterization.


Advances in human growth hormone research.


Blood levels and antibacterial activity of sera in patients treated with cyclacillin.


Plasma renin activity after the use of a new beta-adrenergic blocking agent (I.C.I. 66,032).


Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. II. Effect of serum and insulin.


Autoradiographic studies of pyridine nucleotide metabolism in human culture cells.


Excitatory and inhibitory control of inherent contractions in the sea anemone Calliactis parasitica.


The central effects of the beta-adrenergic blocking agent INPEA.


Hypothermic effect of alpha-sympathomimetic agents and their antagonism by adrenergic and cholinergic blocking drugs.


A comparison of the locomotor stimulant properties of amantadine and l- and d-amphetamine in mice.


Frequency-force relationship on isolated rat and guinea pig atria. Effects of cholinergic and adrenergic receptor antagonists.


Induction of adrenal tyrosine hydroxylase in organ culture.


Inhibition of growth of mouse mammary carcinoma by streptovaricin.


Enzyme activities in vitamin B6-deficient, normal and tumor-bearing animals: effect of hydrocortisone.


Hypothalamic monoamine levels and gonadotrophin secretion following deafferentation of the medial basal hypothalamus.


Input to releasing factor cells.

Input to releasing factor cells.


Enzyme activities and morphometry in skeletal muscle of middle-aged men after training.


The use of drugs in psychiatric interviews: some interpretations based on controlled experiments.


Laboratory studies for every medicated outpatient: are they really necessary?


Letter: Side effects of chlorpromazine and piperacetazine.


Letter: Caveats on diagnosing assassins.


Primary acts of energy conservation in the functional membrane of photosynthesis.


Structure of the mitochondrial electron transport system.


Assembly of inner membrane complexes.

Assembly of inner membrane complexes.


Redox state and chain folding in cytochrome c.


The adoptive transfer of first-set allograft responses by recirculating small lymphocytes in the rat.


Beta-adrenergic receptors: stereospecificity and lack of affinity for catechols.


Inhibition of messenger RNA accumulation but not translation in ultraviolet irradiated hepatoma cells.


A simple apparatus for studying the release of neurotransmitters from synaptosomes.


Action of bamethan on performance time in mice.


Current status of blood alcohol methods.


Rotary lawn mower injuries.

Rotary lawn mower injuries.


The identification of non-barbiturate hypnotics from biological specimens.


China's barefoot doctors.

China's barefoot doctors.


A comparative study of Minnesota Multiphasic Personality Inventory (MMPI) scores of four apparently different black populations.


Editorial: A prognosis for pediatrics.

Editorial: A prognosis for pediatrics.


Immunological facilitation, a broadening of the concept of the enhancement phenomenon.


Cellular immunology and the pathogenesis of graft versus host reactions.


Marine sterols from some gorgonians.

Marine sterols from some gorgonians.


Synthesis of N-oxides with a hepatic microsomal drug oxidase insolubilized on artificial matrices.


Sounder payment programs could foster improvements.


Clinical evaluation of Bametan.

Clinical evaluation of Bametan.


Hydroxy-L-proline as a substrate for hog kidney D-amino acid oxidase.


An educational view of the CHA.

An educational view of the CHA.


Health manpower and advanced education.

Health manpower and advanced education.


OR instrument counts: a manual for standardization.


CHA must stay in health education.

CHA must stay in health education.


Do nurses belong in hospital schools?

Do nurses belong in hospital schools?


Negligence and error in judgment.

Negligence and error in judgment.


A problem-solving package for building committees.


Neuroleptanesthesia, dissociative anesthesia, and hemorrhage.


Management of general anesthesia during hemorrhage.


The effect of adrenergic and cholinergic agents and their blockers upon ureteral activity.


The treatment of delirium tremens: controversy in the literature.


Dihydrofolate reductase from a methotrexate-resistant Escherichia coli.


Regulation of alanine dehydrogenase in Bacillus (licheniformis). Cell extracts of Bacillus licheniformis were found to contain nicotinamide adenine dinucleotide (NAD)-dependent l-alanine dehydrogenase (ADH) (l-alanine: NAD oxidoreductase, EC 1.4.1.1). High specific activities (3.5 to 6.0 IU/mg of protein) were found in extracts of cells throughout growth cycles only when l-alanine served as the primary source of carbon or carbon and nitrogen. Specific activities were minimal (0.02 to 0.04 IU/mg of protein) during growth on glucose, but increased at least sevenfold during the first 5 h of postlogarithmic-phase metabolism. Addition of 10 mM glucose to cultures during logarithmic-phase growth on l-alanine resulted in a rapid decrease in enzyme activity. Addition of 20 mM l-alanine to cells near the completion of log-phase growth on glucose resulted in a 20-fold increase in ADH specific activity during less than one cell generation. Extracts of postlogarithmic-phase cells cultured on glucose, malate, l-glutamate, or Casamino Acids contained intermediate levels of ADH activity. The enzyme was partially purified from crude extracts of B. licheniformis, and apparent kinetic constants were estimated. A role for ADH in the catabolism of l-alanine to pyruvate during vegetative growth on l-alanine and during sporulation of cells cultured on glucose is proposed on the basis of these experimental results.


Evidence that apo-reduced nicotinamide adenine dinucleotide dehydrogenase and apo-electron-transferring flavoprotein from Peptostreptococcus elsdenii are identical.


The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange studies.


The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. II. Dead-end and multiple inhibition studies.


Host-feeding patterns of Florida mosquitoes. IV. Deinocerites.


Symposium on reproduction of arthropods of medical and veterinary importance. V. Reproduction in Diptera of medical importance with special reference to mosquitoes.


Induction of drug-metabolizing enzymes and aryl hydrocarbon hydroxylase by microscope immersion oil.


Protocols for monitoring physician-extenders.


Frequency of eating and dental caries prevalence.


Density-gradient centrifugation of mouse liver mitochondria H2O-D20 gradients.


Simultaneous increases of the adenylate energy charge and the rate of glycogen synthesis in nitrogen-starved Escherichia coli W4597(K).


Nitrate reductase from Chlorella fusca. Reversible inactivation by thiols and by sulfite.


Microsomal electron transport. II. Reduced nicotinamide adenine dinucleotide--cytochrome b5 reductase and cytochrome P-450 as electron carriers in microsomal NADH-peroxidase activity.


NAD malic enzyme in leaves with C-pathway photosynthesis and its role in C4 acid decarboxylation.


25-Hydroxycholecalciferol-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria.


Deficits in instrumental responding after 6-hydroxydopamine lesions of the nigro-neostriatal dopaminergic projection.


Editorial: Selectivity in beta-adrenergic responses: clinical implications.


Carbohydrate metabolism in Acanthamoeba castellanii. II. Carbon dioxide fixation reactions.


Carbohydrases with unusual specificities. 3. A hydrolase splitting p-nitrophenyl 2-deoxy-2-benzamido-beta-D-glucopyranoside--distribution in marine invertebrates and certain mushrooms.


Late bronchial obstructive reaction to experimental inhalation of house dust extract.


The effect of parenteral indoramin on peripheral blood flow in patients with Raynaud's disease or atherosclerosis associated with intermittent claudication.


High-pressure liquid chromatographic determination of adrenergic and antihistaminic compounds in pharmaceutical preparations.


Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.


The effect of chlorpromazine and antihistamines on human blood platelets in vitro and in vivo.


CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity.


GMP reductase in Artemia salina.

GMP reductase in Artemia salina.


Mechanism of enzyme action. VII. Kinetic analysis of the reaction of D-amino-acid oxidase with D-arginine.


Styrylpyrone biosynthesis in Polyporus hispidus. II. Enzymic hydroxylation of p-coumaric acid and bis-noryangonin.


Mammalian fatty acid synthetase. I. Purification and properties of human liver complex.


Mechanism of regulation of the malic enzyme from Fusarium.


Analogy and homology of the dehydrogenases of Oomycetes. I. Regulation of glutamic dehydrogenases and isozyme patterns.


Analogy and homology of dehydrogenases of the Oomycetes. 3. Isoenzyme patterns of malic and isocitric dehydrogenases.


Study of relationship between antihistaminic, anticholinergic and central depressant properties of various antihistaminics.


The evaluation of physician's assistants in radiology.


Measures of skewness and kurtosis of distributions of blood and liver constituents of rats (Rattus norvegicus) at two environmental temperatures.


Experiences of an Army nurse in developing care plans for outpatients with chronic illnesses.


Comparative responses of Peromyscus (white-footed mice) to estradiol benzoate.


The isolation and partial characterization of membranes from dystrophic and normal muscle.


Taste effectiveness of anomers of sugars and glycosides as revealed from hamster taste responses.


Action potentials from a glycerol perfused frog gastrocnemius: a new approach to an old problem.


The effects of temperature, anoxia and sensory stimulation on the heart rate of unrestrained crabs.


Directional instability and oscillation of the acid-base transport system of the tortoise urinary bladder, Damonia subtrijuga.


Experimental shigellosis and intestinal malabsorption in the mouse.


Effect of metabolic inhibitors and chelating agents on 59Fe uptake by the placental tissues of the rat, Rattus norvegicus.


Active amino acid and sugar transport by a unicellular blue-green alga.


Gastric acid secretion and ulcerogenesis in histamine-treated guinea pigs.


Induction by gonadal hormones of hepatic lipogenic enzyme activity in immature pullets.


Proceedings: Some histochemical changes in immature mouse ovaries after gonadotrophin treatment.


Chemical, histochemical, and histopathological studies on corals. Porites spp., parasitized by trematode metacercariae.


A baculovirus from the mosquito Wyeomyia smithii.


Parathelohania legeri infecting Psorophora ciliata.


Emergency medical care--the physician's responsibility.


Growth and sporulation characteristics of Bacillus megaterium under different conditions of nutrient limitation.


Relation between structure of sulphonamides and inhibition of H2-pteroate synthesis in Escherichia coli.


Competitive interaction of preservative mixtures with cetomacrogol.


Adsorption of atropine and hyoscine on magnesium trisilicate.


A comparison of the effects of chronic administration of ethanol and acetaldehyde to mice: evidence for a role of acetaldehyde in ethanol dependence.


Effect of L-dopa in 54Mn incorporation by tissues.


Metabolism of isoprenaline in the intestine.


Isolation of cantharidin  from Cyaneolytta sapphirina.


Prostaglandins in rat tissues.

Prostaglandins in rat tissues.


Effect of O-methylation on the acceleration of efflux of noradrenaline produced by phenethylamine derivatives.


Effect of several dopaminergic drugs and trihexyphenidyl on cholinergic parameters in the rat striatum.


Dose-dependent potentiation or inhibition by Ro4-4602 of 5-HTP hyperthermia in rabbits.


Effect of morphine and chlorpromazine on apomorphine-induced stereotyped behavior.


A refined procedure for determining pA2 values.


D-Glucaric acid as an index of hepatic enzyme induction by anticonvulsant drugs in man.


The micellar weights of the series dioctyl-to-didodecyl phosphatidylcholine.


Tryptamine antagonists and punished behavior.


Evidence for a critical period for postnatal elevation of brain tyrosine hydroxylase activity resulting from reserpine administration during embryonic development.


Cardiovascular and bronchomotor responses to selective beta adrenergic receptor agonists in the anesthetized dog.


Accumulation of amines in the isolated perfused rabbit lung.


The origin of the integrative systems: a change in view derived from research on coelenterates and sponges.


The influence of centrophenoxine and ephedrine on the hyporeactivity of the autonomic centres in patients with cerebral infarction.


The antiulcer and autonomic pharmacology of pyridyl-2-thioacetamide (CMN 131).


Effects of clonidine and some alpha-adrenoreceptor blocking agents on avoidance conditioned reflexes in rats: their interactions and antagonism by atropine.


Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes.


XY-XYY mosaicism associated with major genital defects.


Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.


Methyprylon overdose: interpretation of serum drug concentrations.


Testosterone in normal, cryptorchid and castrated male horses.


Biopsy and the testicular artery of the horse.


The bacterial nitrate reductases. Solubilization, purification and properties of the enzyme A of Escherichia coli K 12.


Enzymatic and chemical synthesis of 3-sulfinopropionic acid, an analog of succinic acid.


Delta4-3 beta-hydroxysteroid dehydrogenase activity in rat liver. Intracellular distribution and sex dependency.


Steroid-synthesizing cellular sites in amphibian ovary. A histochemical study.


Induced changes in neurosecretory activity of adult female Schistocerca gregaria in relation to feeding.


Trade-offs and conflicts in evaluation of health system alternatives: methodology for analysis.


Biochemical correlation of oncogenesis with ontogenesis.


Phenytoin intoxication induced by sulthiame in epileptic patients. Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.


Comparison of the predictive validity of two measures of psychotherapy prognosis.


The organization and implementation of advanced medical training.


Noradrenergic mediation of traumatic spinal cord autodestruction.


Benzodiazepines for supplementing steroid anesthesia.


Venezuelan equine encephalitis epidemic in Texas, 1971.


Foreign medical graduates and the medical underground.


The effects of substrates of mixed function oxidase on ethanol oxidation in rat liver microsomes.


Amphetamine and thermoregulation: studies in the unrestrained and curarized rat.


Personality disorder and the international classification of diseases.


Psychosexual dynamics of patients undergoing mammary augmentation.


Medical Research Council Neurochemical Pharmacology Unit.


Enzymatic reduction of disulfide bonds in fibrin-ogen by the thioredoxin system. I. Identification of reduced bonds and studies on reoxidation process.


Correlation of immunological function with splenic histopathology during the preclinical stages of host-versus-graft syndrome in parent-F1 mouse chimeral.


Feeding elicited by alpha and beta adrenoceptor agonists in sheep and cattle.


Letter: The retention of graft-versus-host-reactive host lymphocytes in a vascularized spleen graft.


Relationship between prostagandin E1, polyphloretin phosphate and alpha and beta adrenoceptor-bound feeding loci in the hypothalamus of sheep.


Biotransformation of fluroxene in man.

Biotransformation of fluroxene in man.


Inhibition of adrenergic function in the treatment of hypertension.


Drug combinations as rational antihypertensive therapy.


Conference studies relationship between quality of care and medical training.


Fatty acid synthesis de novo in human adipose tissue.


Leukemia induction in C3H mice following their inoculation with normal AKR lymphoid cells.


Immunodepression as a factor during 3-methylcholanthrene carcinogenesis and subsequent tumour growth in mice.


Connective tissue disorders in otolaryngology.


5-Keto-D-fructose: formation and utilization in the course of D-fructose as similation by Gluconabacter cerinus. The accumulation of 5-keto-d-fructose (5KF) by Gluconobacter cerinus grown on d-fructose in unbuffered medium was shown to be optimal at pH 4.0 after cell growth ceased. During the exponential phase of growth or at neutral pH after the onset of the stationary phase, 5KF production continued but did not accumulate because of its rapid reutilization by reduction to d-fructose. The extent of isotope incorporation into C5 of ribonucleic acid ribose when cells were grown in the presence of specifically labeled d-glucose and d-fructose clearly indicated that (i) the hexose monophosphate oxidative pathway is the predominant metabolic route for carbohydrate assimilation and (ii) extensive randomization of label between C1 and C6 of d-fructose occurred prior to its conversion into pentose. It is suggested that the cyclic oxidation and reduction through the symmetrical 5KF molecule, which accounts for the observed randomization of isotope in d-fructose, provides the cells with an effective mechanism for the regeneration of nicotinamide adenine dinucleotide phosphate during the period of intensive growth.


In situ activity of enzymes on polyacrylamide gels of a deoxyribonucleic acid-membrane fraction extracted from pneumococci. A deoxyribonucleic acid (DNA)-membrane fraction extracted from Diplococcus pneumoniae was subjected to polyacrylamide gel electrophoresis after treatment with 0.16% sodium dodecyl sulfate. At least two DNA polymerase activities were detected by in situ assays with appropriate substrates, templates, and inhibitors, including a co-polymer of deoxyadenylic and thymidylic acid and N-ethylmaleimide. This activity coincided with a fraction in the gel containing 7.5, 9.4, and 24%, respectively of the DNA, phospholipid, and protein present in the DNA-membrane fraction before electrophoresis and sodium dodecyl sulfate treatment. Assays with minced gels showed that several nuclease activities, deoxyribonucleotide kinase activity, and DNA ligase activity also coincided with this fraction. However, ribonucleoside diphosphate reductase activity did not. These results demonstrate that a complex of enzymes involved in DNA replication is firmly bound to the DNA-membrane fraction in pneumococci.


Purification and properties of a diacetyl reductase from Escherichia coli. A reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase with the ability to reduce diacetyl has been isolated from Escherichia coli and has been purified 800-fold to near homogeneity. The product of the reduction of diacetyl was shown to be acetoin. The enzyme proved to catalyze the oxidation of NADPH in the presence of both uncharged alpha- and beta-dicarbonyl compounds. Even monocarbonyl compounds showed slight activity with the enzyme. On the basis of its substrate specificity, it is suggested that the enzyme functions as a diacetyl reductase. In contrast to other diacetyl reductases, the one reported here is specific for NADPH and does not possess acetoin reductase activity. The pH optimum of this enzyme was found to be between 6 and 7. The maximal velocity for the NADPH-dependent reduction of diacetyl was determined to be 9.5 mumol per min per mg of protein and the K(m) values for diacetyl and NADPH were found to be 4.44 mM and 0.02 mM, respectively. The molecular weight was estimated by gel filtration on Sephadex G-100 to be approximately 10,000.


Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. II. Relationship between IgM immunoglobulin levels and the ability to give an IgM antibody response. Serum IgM immunoglobulin levels and antibody responses to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) were assessed for F(1), F(2), and backcross progeny derived from crosses between high responding BALB/cAnN (B) and low responding CBA/HN (C) mice. The results obtained confirmed our original hypothesis, namely, that a major component, present on the X chromosome, governs the ability to respond to SSS-III in a decisive manner. Although all low responding C mice had low IgM levels, both intermediate and high responders had high IgM levels of the same magnitude. Treatment with bacterial lipopolysaccharides (LPS) resulted in a significant increase in the IgM levels of low responding C mice. While the IgM levels attained were similar to those of high responding B mice, not given LPS, no antibody specific for LPS appeared to be produced. These findings suggest that C mice are unable to make an IgM antibody response to SSS-III and other polysaccharide antigens, despite the fact that they possess the capacity to synthesize normal amounts of IgM immunoglobulin.


Synergy among responding lymphoid cells in the one-way mixed lymphocyte reaction. Interaction between two types of thymus-dependent cells. The present studies have shown that two subpopulations of thymus-dependent lymphocytes may act synergistically in the mixed lymphocyte reaction (MLR) in the mouse. One subpopulation was well represented in the young adult thymus and the other in lymph nodes. For optimum synergy, both populations must be allogeneic to the stimulator cells. Pretreatment of either population with mitomycin-C abolished synergy. Anti-theta serum abolished both MLR responding and synergizing activities of lymphoid cells. The two thymus-dependent subpopulations were both present in the spleen, and displayed different migratory patterns when injected into irradiated mice: one population went to spleens of the irradiated mice, the other to lymph nodes. The effects of anti-thymocyte serum on the MLR and upon synergy were assessed. While minor differences exist and are herein described, our overall results strongly suggest that in our experiments with synergy in MLR, we may be dealing with the same T(1)- and T(2)-cell subpopulations described by Cantor and Asofsky and coworkers (1, 2, 4, 5, 14) as displaying synergy in the graft-vs.-host reaction.


8-(Omega-aminoalkylamino)quinolines as potential prophylactic antimalarials.


10-Alkyl- and 10-aminoalkyl-2,2'-bis(trifluoromethyl)-3,10'-biphenothiazines.


Effect of L-DOPA on brain concentration of dopamine and homovanillic acid in rats after chronic manganese chloride administration.


Stimulation of serotonin N-acetyltransferase in pineal organ culture by drugs.


Inhibition of the biochemical and morphological maturation of adrenergic neurons by nicotinic receptor blockade.


Liquid chromatography in pharmaceutical analysis: determination of cough-cold mixtures.


Health manpower: trends and issues.

Health manpower: trends and issues.


Clonal cell lines from the rat central nervous system.


Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors.


The pineal gland: a neurochemical transducer.


Peptide regulation of bursting pacemaker activity in a molluscan neurosecretory cell. Vasopressin and related peptides (10(-9) to 10(-6) molar) induced bursting pacemaker potential activity and altered the current-voltage relations of the membrane in a specific molluscan neurosecretory cell. These effects long outlasted the period of application of the peptides. Sensitivity of the cell to these peptides was primarily localized on the axon hillock region. The observed effects do not resemble conductance changes evoked by conventional neurotransmitters, but rather suggest a membrane regulatory role for these peptides, and thus may be indicative of a new form of information transfer in the nervous system.


Immunotherapy in leukemia. Experimental and clinical approaches.


Effect of lithium on deiodinating activity of various rat tissues in vitro.


Molecular and catalytic properties of transglutaminases.


The pathophysiologic panorama of myocardial ischemia and infarction.


Clinical evaluation of superior oblique function.


Classification and treatment of superior oblique palsy.


Superior oblique surgery.

Superior oblique surgery.


The function of the superior oblique muscle in man. A correlation of clinical observation with experimental findings.


Human 6-phosphogluconate dehydrogenase. Purification of the erythrocyte enzyme and the influence of ions and NADPH on its activity.


Nitrite reductase from Achromobacter fischeri: molecular weight and subunit structure.


Xanthogranulomatous pyelonephritis.

Xanthogranulomatous pyelonephritis.


Effects of dehydroepiandrosterone and its conjugates upon the activity of glucose-6-phosphate dehydrogenase. V. Inhibition of glucose-6-phosphate dehydrogenase in human placenta.


Surgical grand rounds: cecal volvulus.

Surgical grand rounds: cecal volvulus.


The non-visualizing gallbladder.

The non-visualizing gallbladder.


EKG of the month.

EKG of the month.


Editorial: Unnecessary surgery.

Editorial: Unnecessary surgery.


The view box.

The view box.


Activity of guinea pig liver transglutaminase toward ester analogs of amide substrates.


Studies on stabilization of the oxidative phosphorylation system. 3. The effects of substrates and ATP on sensitivity of various energy-linked functions of submitochondrial particles to phospholipase a from Crotalus terrificus venom.


Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase.


Dihydrodipicolinic acid reductase.

Dihydrodipicolinic acid reductase.


Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol.


Beta-adrenoceptor studies. 1. In vitro beta-adrenergic blocking, antiarrhythmic, and local anesthetic activities of a new series of aromatic bis(2-hydroxy-3-isopropylaminopropyl) ethers.


Derivatives of 3,4-dihydrocarbostyril as beta-adrenergic blocking agents.


Studies on beta-lactams. 35. Antibacterial activity of monocyclic beta-lactams.


Editorial: The quality of life in later years.


Learning impairment in rats after 6-hydroxydopamine-induced depletion of brain catecholamines.


Problems of inert gases.

Problems of inert gases.


Pathogenesis and treatment of decompression sickness.


Activities of glycolytic and citric acid cycle enzymes in oral leukoplakia.


Immobilization of enzymes by radiopolymerization of acrylamide.


Immune response to acute otitis media in children. I. Serotypes isolated and serum and middle ear fluid antibody in pneumococcal otitis media. Seventy percent of pneumococci isolated from the middle-ear cavity of infants and children with acute otitis media were of one of the seven serotypes 1, 3, 6, 14, 18, 19, or 23. The immunological response in the serum and middle-ear fluid from otitis media caused by one of these serotypes was studied in 61 children by using either indirect hemagglutination or indirect fluorescent antibody tests, or both. Twenty-six of the patients had pneumococcal antibody present in the acute serum and 28 had it in the convalescent serum by at least one method. Thirteen of the 49 middle-ear fluids examined had antibody by the indirect fluorescent antibody technique. Serum pneumococcal antibody was found to reside predominantly in the immunoglobulin G or immunoglobulin M classes, whereas pneumococcal antibody with middle-ear fluid was found to be distributed equally among all three classes. Approximately 25% of the patients (16 of 61) had a positive immune response to their infection as evidenced by increased levels of pneumococcal antibody in the convalescent serum. The percentage of patients responding immunologically increased with age: 12% of infants less than 12 months showed a significant response, whereas 48% of children over 24 months responded.


Enzyme concentrations in serum after prolonged physical exercise.


Nitrofurfuryl heterocycles. 12. 4-Amino-6-(5-nitro-2-furyl)isoxazolo(5,4-d)pyrimidines and 4-amino-2-(5-nitro-2-furyl)pyrimido(4,5-d)pyrimidines.


Oximes of 3-formylrifamycin SV. Synthesis, antibacterial activity, and other biological properties.


Synthesis and pharmacological properties of 5a,6,7,8,9,10,10a,11-octahydrobenzo(b)cyclohepta(e)-(1,4)thiazine derivatives.


Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs. Adenylate cyclase (EC 4.6.1.1), selectively stimulated by low concentrations of dopamine, has been found in the olfactory tubercle, the nucleus accumbens, and the caudate nucleus of several mammalian species. Several different classes of drugs effective in the treatment of schizophrenia (antipsychotic drugs) were potent inhibitors of the stimulation by dopamine of the enzyme from these various regions. The drugs studied included representatives of the phenothiazine, butyrophenone, and dibenzodiazepine classes. The inhibition by these antipsychotic drugs was competitive with respect to dopamine. The most potent of the antipsychotic agents tested was fluphenazine, which had a calculated inhibition constant (K(i)) of about 5 x 10(-9) M. For each of several drugs tested, the K(i) for the enzyme from the olfactory tubercle was similar to that for the enzyme from the caudate nucleus. Several compounds closely related structurally to the psychoactive phenothiazines, but which have little or no antipsychotic or extrapyramidal actions clinically, had low relative potencies as inhibitors of dopamine-stimulated adenylate cyclase activity. The results, considered together with other data, raise the possibility that the therapeutic effects, as well as the extrapyramidal side effects, of these antipsychotic agents may be attributable, at least in part, to their ability to block the activation by dopamine of specific dopamine-sensitive adenylate cyclases in the human brain.


The stoichiometry of the conversion of cholesterol and hydroxycholesterols to pregnenolone (3beta-hydroxypregn-5-en-20-one) catalysed by adrenal cytochrome P-450. The stoichiometry of the side-chain cleavage of cholesterol (cholest-5-en-3beta-ol), 20alpha-hydroxycholesterol (cholest-5-ene-3beta,20alpha-diol), and 20alpha,22-dihydroxycholesterol (cholest-5-ene-3beta,20alpha,22-triol) has been examined with respect to TPNH, oxygen and H(+). Side-chain cleavage of cholesterol can be described by the following equation:Cholesterol + 3TPNH + 3H(+) + 3O(2) --> Pregnenolone (3beta-hydroxypregn-5-ene-20-one) + isocapraldehyde + 3 TPN(+) 4H(2)OStoichiometry of 20 alpha-hydroxycholesterol is 2TPNH and 2O(2) per mole of cleavage and with 20alpha, 22-dihydroxycholesterol the values are 1:1:1. In addition 1 mole of H(+) is consumed per mole of TPNH oxidized in each of these reactions. These observations are in keeping with a mechanism previously proposed in the literature, namely:Cholesterol --> 20alpha-OH-Cholesterol --> 20alpha, 22-di-OH-Cholesterol --> pregnenoloneDiscordant observations are reviewed and it is concluded that insufficient data are available to sustain objections to this pathway.


Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: evidence for function of the gamma-glutamyl cycle. 5-Oxoprolinase catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to L-glutamate with concomitant stoichiometric cleavage of ATP to ADP and inorganic orthophosphate. In this reaction, a step in the gamma-glutamyl cycle, 5-oxoproline (formed by the action of gamma-glutamylcyclotransferase on gamma-glutamyl amino acids, which are in turn formed by transpeptidation of amino acids with glutathione), is made available for glutathione synthesis. When mice are injected with L-2-imidazolidone-4-carboxylate, a competitive inhibitor of 5-oxoprolinase, they accumulate 5-oxoproline in their tissues (kidney, liver, brain, and eye) and excrete it in the urine. Mice given the inhibitor together with one of several L-amino acids accumulate and excrete much more 5-oxoproline than when they are given the inhibitor alone. Such augmentation of 5-oxoproline accumulation offers evidence for the function of the gamma-glutamyl cycle in vivo and supports the view that 5-oxoproline is a quantitatively significant metabolite.


Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. The specific activities of both the succinate dehydrogenase-coenzyme Q(10) reductase and the DPNH-cytochrome c reductase [NADH:(acceptor)oxidoreductase, EC 1.6.99.3] were determined in mitochondria from 40 diseased gingival biopsies from patients with periodontal disease and from 24 control biopsies from nondiseased areas (clinically evaluated) of gingival tissues from the same mouths of the patients from whom the diseased gingival tissues were taken. The control tissue was taken during normal surgical procedures, such as for gingival recontouring and tuberosity removal. The diseased gingival biopsies showed a mean specific activity for the succinate dehydrogenase-coenzyme Q(10) reductase which was higher (P < 0.02) than that of the control biopsies, and which increased (P < 0.01) when the assays utilized exogenous coenzyme Q(3), and corresponded to an average deficiency of coenzyme Q(10)-enzyme activity of 35%. About 60% of the 40 diseased gingival tissues showed a deficiency of coenzyme Q(10) at its site in this succinate-coenzyme Q(10) enzyme. Of the 24 control tissues, 20% showed deficiencies of coenzyme Q(10). As a group, the control tissues showed no deficiency of coenzyme Q(10). No deficiency of coenzyme Q(10) at its site in DPNH-cytochrome c reductase was observed for either the control or diseased gingival tissues, as groups or individually.


Neurotransmitters.

Neurotransmitters.


Early stages in DNA binding and uptake during genetic transformation of pneumococci. Ethylenediaminetetraacetate and other divalent-cation-complexing agents greatly stimulate the cellular binding of DNA molecules to competent pneumococci, while the appearance of genetic transformants and nuclease-resistant DNA binding are completely inhibited. Based on this finding, we developed an experimental system in which three early and consecutive stages of genetic transformation can be experimentally separated: (i) attachment of DNA molecules to cell surface sites that are only demonstrable in the competent state; (ii) a divalent-cation-dependent nucleolytic splitting and release of the adsorbed molecules to the medium; and (iii) emergence of potential transformants accompanied by an energy-requiring and divalent-cation-dependent process in which the cell-associated DNA molecules become inaccessible to shearing forces, nucleases, anti-DNA serum, and polycations.


Comparison of alpha- and beta-receptor stimulation in the circular and longitudinal muscle of the oestrogen and progesterone dominated rabbit uterus.


Use of the mouse in pharmacodynamic testing.


Ampicillin and tetracycline in the treatment and prophylaxis of chronic bronchitis. Ampicillin and tetracycline, in doses of 2 g a day, were compared in the treatment of acute exacerbations of chronic bronchitis. Seventy-nine patients were followed for 3 to 29 months and were treated for 118 exacerbations. Clinical improvement occurred after 10 days of treatment with either drug in over 80% of the cases. Haemophilus influenzae and Diplococcus pneumoniae were eradicated from the sputum more than 60% of the time, but in general there was a poor correlation between bacteriological clearing and clinical response. The effect of chemoprophylaxis with ampicillin and tetracycline in doses of 1 g a day on the frequency of acute exacerbations of bronchitis was compared with that of a placebo. Seven hundred eighty prophylactic regimens, consisting of one capsule every 12 hr for 5 days beginning with the first sign of a cold, were prescribed for 76 patients. Irrespective of the regimen, an acute exacerbation of bronchitis was encountered at approximately 13% of the follow-up visits to the clinic.


Effect of cyanide on respiratory control of electron transporting particles.


An immunochemical study of the induction of tyrosine hydroxylase in rat adrenal glands.


Binding of receptor-hydrocortisone complexes to isolated nuclei from embryonic neural retina cells.


Energization of phenylalanine transport and energy-dependent transhydrogenase by ATP in cytochrome-deficient Escherichia coli K12.


Adrenergic regulation of glycogen breakdown in the heart and skeletal muscle. The role of beta-adrenergic receptor.


Regulation of delta-aminolevulinic acid synthetase by drugs and steroids in isolated perfused rat liver.


The role of macrophages in tumour immunity.


Cell replication in the follicular epithelium of the adult mosquito.


Adrenergic regulation of glycogen breakdown in the heart and skeletal muscle. The role of alpha-adrenergic receptor.


Preoperative blood transfusion in the safe surgical management of pheochromocytoma: a review of 46 cases.


Simple cryptorchidism: the value of the excretory urogram as a screening method.


Psychotropic drugs--are they justified?

Psychotropic drugs--are they justified?


Serological types of Diplococcus pneumoniae strains isolated in Germany. Comparison with type patterns in other countries.


Allogeneic marrow grafting using HL-A matched donor-recipient sibling pairs.


Energy-linked reactions in mitochondria: the effects of some inhibitors and their use in the location of the transhydrogenase enzyme.


The spontaneous firing pattern of forebrain neurons. I. The effects of dopamine and non-dopamine depleting lesions on caudate unit firing patterns.


Diphasic binding of carbon monoxide with cytochrome P-450 of rat liver microsomes reduced by NADPH.


6-Hydroxydopamine and striatal acetylcholine levels.


Hernia and scrotal problems in childhood.


Dopa decarboxylase activity in Aedes aegypti: a preadult profile and its subsequent correlation with ovarian development.


At Brantford General Hospital: outreach to the disabled.


Nine deaths linked to cross-connection: Sudbury General inquest makes hospital history.


A patient died; a doctor convicted: for want of a bed.


Do hospitals deserve special protection?


Hospital and nursing home food service supervisors: accent on education.


Evaluation: the core of personnel management.


An overview of food-service systems.

An overview of food-service systems.


Think again about community health centres.


Hospital of food service company--which is the best employer?


Structural alterations in cultivated striated muscle cells from anthomedusae (hydrozoa). A metaplasiaic event.


Drugs for schizophrenia.

Drugs for schizophrenia.


The present status of the Physician's Assistant Program of the Bowman Gray School of Medicine.


The pharmacologic basis for clinical use of beta adrenergic blocking drugs.


Cor pulmonale.

Cor pulmonale.


Inhibition of platelet aggregation by anti-5-hydroxytryptaminic and alpha-adrenergic blocking agents.


Glucose 6-phosphate dehydrogenase of human blood platelets. Kinetics and regulatory properties.


Derepression of mitochondria and their enzymes in yeast: regulatory aspects.


Chemical modification studies of chloroplast membranes. Effects of diazonium coupling on electron transfer in photosystem I.


The enzymatic conversion of cis-(14C)phytofluene, trans-(14C)phytofluene, and trans-zeta-(14C)carotene to more unsaturated acyclic, monocyclic, and dicyclic carotenes by a cell-free preparation of red tomato fruits.


Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes.


Regulation by various hormones and agents of adenosine-3',5'-monophosphate levels in islets of Langerhans of rats.


Effects of chronic administration of drugs which modify neurotransmitter re-uptake, storage and turnover on levels of tyrosine and tryptophan hydroxylase in rat brain.


Redox properties of the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 and reduced nicotinamide adenine dinucleotide-cytochrome b5 reductases.


Depression of complement activity in tree strains of mice after tumor transfer.


Ultraviolet inactivation of murine leukemia virus and its assay in permissive and non-permissive cells.


Arkansas Medical Society. Report of the Committee on Medical Legislation.


Arkansas Medical Society. The year ahead.


Arkansas Medical Society. Address of the president.


Heat and cold injuries.

Heat and cold injuries.


Collaborative study of an ion exchange method for the chromatographic separation of mixtures containing expectorants, sympathomimetic amines, antihistamines, or phenothiazine in pharmaceuticals.


Herpesvirus saimiri: viability in four species of hematophagous insects and attempted insect transmission to marmosets.