Fatty acid desaturation by mammary gland microsomes from lactating mice.


Problems faced by hypertensive patients.


Army physicians' attitudes about physicians' assistants.


[Driving ability as influenced by various drugs].


Effects of metamphetamine, pipradrol and methylphenidate on instrumental conditioning and spontaneous motor activity in the immature rat.


Three forms of the tentacled and non-tentacled fresh-water coelenterate polyp genera Craspedacusta and Calpasoma.


Inborn errors of metabolism-the relationship of clinical and biochemical abnormalities.


Untoward effects of a sympathomimetic amine.


Alternate pathways of L-rhamnose transport in Arthrobacter pyridinolis.


Two-step binding of adenosine diphosphate to L-glutamate dehydrogenase. Effect on the binding of reduced nicotinamide adenine diphosphate and on enzymatic catalysis.


Pharmacological properties of a new beta-blocking agent (1-isopropylamino-3-(2-methyl-3-nitrophenoxy)-propan-2-ol).


Joint action of diquat and related one-electron transfer agents with propoxur and fenthion against mosquito larvae.


Differentiation of neuroblastoma cells induced in culture by 6-thioguanine.


An automated lighting cycler for the insectary.


Biological evaluations of slow release formulations of aldicarb.


The elimination of graft-versus-host cells from an immune population. A potential tool in cancer immunotherapy.


By the London post. Continuing education and the state of medical practice.


Treatment of severe asthma.

Treatment of severe asthma.


Neurotransmitter synthesis in inner ear and lateral line sense organs.


Factors influencing the microsomal metabolism of 3H-reserpine.


Ultrastructural evidence for a sensory-motor neuron in Ctenophora.


Effect of phenformin on gluconeogenesis in perfused rat liver. II. Dependence on the ATP-ADP ratio.


Intermolecular energy transfer in the bioluminescent system of Aequorea.


Haemodynamic and coronary vascular responses after beta-adrenoceptor blockade in the anaesthetised dog: a comparison of tolamolol with practolol and propranolol.


Early events in lens regeneration: changes in cyclic AMP concentrations during initiation of RNA and DNA synthesis.


Haemolymph gases and buffers in Ascaris lumbricoides.


Seasonal changes in phenylethanolamine-N-methyl transferase and monoamine oxidase activity in the ground squirrel (Citellus citellus).


On the presence of subarachnoid fluid in the mudpuppy, Necturus maculosus.


Comparative investigations on lipolysis and re-esterification in adipose tissue of man and various species of mice.


The effect of treatment provided by dentists and therapists in the South Australian School Dental Service.


Effect of dietary dilution on food intake, weight gain, plasma glucose and insulin and adipose tissue insulin sensitivity in rats.


Effects of black widow spider venom on acetylcholine release from Torpedo electric tissue slices and subcellular fractions in vitro.


Red squirrel metabolism during incline running.


Seasonal changes in calcium, magnesium, copper and zinc content in the liver of the common frog, Rana temporaria L.


Digestive enzymes in Eurytoma amygdali and their relation to food digestion and to the boring process of the emergence holes in almond fruits.


Temperature regulation in the tree shrew Tupaia glis.


Effects of cystine, niacin and taurine on cholesterol concentration in the Japanese quail with comments on bile acid metabolism.


Coronary-supplied compact shell of ventricular myocardium in salmonids: growth and enzyme pattern.


Relations between heart muscle enzyme pattern and directly measured tolerance to acute anoxia.


Evaporative heat loss in the California sea lion and harbor seal.


Urate and cation interactions in the liquid and precipitated fractions of avian urine, and speculations on their physico-chemical state.


Nematocyst lipids of the Portuguese man-of-war Physalia physalis.


The enzymatic content of the venoms of the sea nettle and the Portuguese man-o'-war.


On the biosynthesis and composition of sterols and sterolesters in some sea anemones (Anthozoa).


Influence of methamphetamine and neuroleptic drugs on tyrosine hydroxylase activity.


Haemodynamic and coronary vascular responses after beta-adrenoceptor blockade in the anaesthetised dog: a comparison of tolamolol with practolol and propranolol.


Fibrinogen and metastases.

Fibrinogen and metastases.


Impact of fluoridated water on the caries-experience of Naval recruits.


Neuroanatomy of the mesothoracic ganglion of the cockroach Periplaneta americana (L.). I. The roots of the peripheral nerves.


The electromechanochemical model for energy coupling in mitochondria.


Studies on electron transport and energy-linked reactions using mutants of Escherichia coli.


Choreo-athetosis and encephalopathy induced by phenytoin. Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy. In both patients choreo-athetoid involuntary movements were prominent. Blood phenytoin concentrations were above 30 mug/ml. When phenytoin was given in smaller doses and its level in the blood fell the involuntary movements and other clinical manifestations disappeared.


Data set provides uniformity, flexibility.


Enterococcal lung abscess: medical and surgical therapy.


Effect of inhibitors of mitochondrial protein synthesis on the NADH and NADPH glutamate dehydrogenases in yeast.


Report of the International Executive Committee on the Thirteenth International Congress of Radiology from the International Commission of Radiation Units and Measurements (ICRU).


Sterol metabolism. XXIX. On the mechanism of microsomal lipid peroxidation in rat liver.


Psychological factors associated with rheumatoid arthritis: review of the literature.


The effect of N-alkyl chain length of stereochemistry on the absorption, metabolism and during excretion of N-alkylamphetamines in man.


Metaproterenol.

Metaproterenol.


Drugs for relief of nausea and vomiting.


Letter: Physical examinations by physician's assistants.


Explaining variability in caries experience using an ecological model.


Plasma testosterone and estradiol concentration in prepubertal boys with cryptorchidism before and after dexamethasone and after human chorionic gonadotropin administration.


Iproveratril: a nonspecific antagonist of peripheral vascular reactivity.


Studies on mitochondrial proteins. II. Localization of components in the inner membrane: labeling with diazobenzenesulfonate, a non-penetrating probe.


Proceedings: Influence of beta blocking agents on cardiac function and myocardial oxygen consumption in the isolated supported heart preparation of the dog.


A new fungus which attacks mosquitoes and related Diptera.


Proceedings: Beta-adrenergic blocking and antiarrhythmic activities of 1-(7-indenyloxy)-3-tert-butylaminopropane-2-OL hydrochloride (YB-11).


Proceedings: Effect of acetaldehyde on hepatic microsomal drug-metabolizing enzyme activities in vitro.


Proceedings: Physiological and pharmacological studies on 'caudate spindle'.


Proceedings: Pharmacological actions of palythoatoxin isolated from the zoanthid, Palythoa tuberculosa.


Proceedings: A pharmacological analysis of a putative neurotransmitter substance released from the non-adrenergic inhibitory nerve.


Proceedings: Presynaptic actions of beta-blockers.


Pharmacokinetic properties of the beta-adrenergic receptor blocking drugs.


Adverse reactions to beta-adrenergic receptor blocking drugs: a report from the Boston collaborative drug surveillance program.


Pharmacodynamic properties of beta-adrenergic receptor blocking drugs in man.


Adverse effects of beta-adrenergic receptor blocking drugs on respiratory function.


Hepatic metabolism in normal and genetically obese mice.


Clinical use of piperacetazine in dogs and cats.


Beta-adrenergic receptor blocking drugs in angina pectoris.


Responses of the murine myeloid colony-forming cell to ansamycin antibiotics. The in vitro susceptibility of murine myeloid colony-forming cells to the antiproliferative activities of three ansamycin antibiotics was determined. These cells were found to be 10- to 40-fold more susceptible than the corresponding human ones.


Fluorescence and phosphorescence of antihistamines having the diphenylmethane chromophore. Effect of halide ions on luminescence.


Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats.


Influence of light and darkness on the turnover of noradrenaline in the rat heart.


The prevalence of injured anterior teeth in English schoolchildren and adults.


Pulmonary infiltrates with eosinophilia.


Acute psychosis.

Acute psychosis.


A comparison of thymus dependent and thymus independent antibody responses made by different numbers and populations of immunocompetent cells.


Proceedings: Acute and subacute toxicities of levomethiomeprazine.


I.M.A. and the international medical fraternity.


Proceedings: Circulatory responses to insulin administration in the rabbit. 2. Effects of adrenergic blockade.


The coronary blood flow effects caused by the carotid sinus reflex and the exogenous catecholamine.


Comparison of three- and four-year medical school graduates.


Patient management by telephone by child health associates and pediatric house officers.


Peripheral facial paralysis and systemic disease.


A liveborn triploid infant.

A liveborn triploid infant.


Ribonucleoside 5'-thiodiphosphates as substrates for Escherichia coli ribonucleotide reductase.


NADPH-dependent formation of thymidine diphosphodihydrostreptose from thymidine diphospho-D-glucose in a cell-free system from Streptomyces griseus and its correlation with streptomycin biosynthesis.


Control of lipid metabolism in adipose-tissue homogenates of fasted refed rats.


Aplysia acetylcholine receptors: blockade by and binding of alpha-bungarotoxin.


Reaction of ozone with nicotinamide and its derivatives.


Inflammation and "writing syndrome" inducing effects of PGE1 PGE2 and the inhibition of these actions.


Salmonella in pigs on farms feeding pellets and on farms feeding meal.


Kanamycin and neomycin resistance in Mycobacterium ranae (fortuitum) associated with serological and biochemical markers.


Regulation of fatty-acid synthesis in higher animals.


The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms.


Stabilizing the alkali-generated fluorescent derivatives of NAD and NADP.


On the peptidoglycan of the cell walls of Pseudomonas aeruginosa. Structure of the peptide side chains.


Modification of the "decarboxylase" method of glucose specific radioactivity determination.


Letter: Caries and cereals.

Letter: Caries and cereals.


Equilibrium kinetic study of the catalytic mechanism of oxidative deamination of alanine by bovine liver glutamate dehydrogenase.


Implication of a tryptophyl residue in the active site of dihydrofolate reductase.


Intestinal secretion.

Intestinal secretion.


The conversion of cortisol to 11beta-hydroxyandrostenedione by beef adrenal tissue.


Amino acid metabolism.

Amino acid metabolism.


Why do schizophrenic patients refuse to take their drugs?


Acute hemodilution: its effect of hemodynamics and oxygen transport in anesthetized man. The effects of acute normovolemic hemodilution on hemodynamics, oxygen transport, tissue perfusion and blood volume were studied. The subjects were four patients undergoing total hip replacement with prebleeding and hemodilution under fluoroxene and nitrous oxide anesthesia. The hematocrit was reduced to 29% and 21% by bleeding in two steps with simultaneous infusion of plasmanate and lactated Ringer's solution. The major compensation was a rise in CO to 123% and 136%. Systemic oxygen transport (COX arterial O(2) content) was only slightly reduced and the arteriovenous oxygen difference decreased. Tissue perfusion remained excellent. Blood volume was slightly expanded. The procedure was well tolerated by this group of selected patients, and homologous blood utilization was markedly reduced.


Neuromuscular effects of the nematocyst toxin from the scyphozoan medusa, Chrysaora quinquecirrha.


Course of transplanted cadaver donor kidneys with previously existing pathology. Seventeen cases were studied in which the contralateral donor kidney was available for comparison with the transplanted kidney after it was removed from the host following varying periods of survival. The following morphologic observations were made: Arteries exhibiting arteriosclerosis appeared, in the new host, to take on a distinct new cellular deposit which was superimposed on the previously existing hyalinization in the intima. Except for one instance in which the host had secondary hyperparathyroidism, calcification in the donor organ did not undergo significant change. In some instances, the lymphocytes which existed in the donor kidney prior to transplantation appeared to undergo proliferation and produce a localized graft-versus-host reaction in the recipient.


Failure of beta-adrenergic receptor blockade to prevent arrhythmias induced by sympathetic nerve stimulation. Cardiac arrhythmias produced by electrical stimulation of the ventrolateral cardiac sympathetic nerve in dogs were not blocked by the combined administration of propranolol and practolol in amounts that completely blocked cardiac beta-adrenergic receptors. Blockade of cardiac alpha-adrenergic receptors, as well as cardiac cholinergic receptors, also had no influence on the arrhythmias. These results suggest that the adrenergic neuroeffector junction is fundamentally different from any hitherto described, differing perhaps in the neurotransmitter involved or in the nature of the receptor.


Glucose 6-phosphate and 6-phosphogluconate dehydrogenases and their control mechanisms in Escherichia coli K-12.


Tentative correlations between some spectroscopic and biological properties of phenothiazine and parafluorobutyrophenone derivatives.


The use of mass spectrometry for the identification of metabolites of phenothiazines.


Binding of phenothiazines and related compounds to tissues and cell constituents.


The binding behavior of phenothiazines and structurally related compounds to albumin from several species.


Tissue accumulation of metabolites during chronic administration of piperazine-substituted phenothiazine drugs.


Sex differences in long-term adverse effects of phenothiazines.


Evolutionary origin of extrapyramidal disorders in drug-treated mental patients, its significance, and the role of neuromelanin.


Pigmented hyperkeratosis among schizophrenic patients treated with nicotinic acid.


The use of combined gas chromatography-mass spectrometry techniques for the identification of hydroxylated and dihydroxylated metabolites of phenothiazine drugs.


The pharmacokinetics of butaperazine in serum.


Clinical effectiveness of piperacetazine injection in schizophrenic patients: a controlled study.


Chemical, pharmacological, and metabolic considerations on thiothixene. Introduction: chemical and pharmacological relationship of thioxanthenes and phenothiazines.


Effect of phenothiazines on central cholinergic activity.


Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.


The action of chlorpromazine on the metabolism of cyclic adenosine 3',5'-monophosphate.


Prevention of rejection reaction without general immunosuppression.


A comparison of clindamycin and penicillin V in the treatment of oral infections.


Letter: Testicular tumors in unilateral cryptorchidism.


Effect of cis-platinum(II)diamminedichloride and gallium nitrate on the ability of spleen cells to induce a graft-versus-host reaction.


Natural focality of viral infections transmitted by mosquitoes.


Prevalence and treatment of vitamin D deficiency in children on anticonvulsant drugs.


Studies of adrenergic mechanisms in relation to histamine sensitivity in children immunized with Bordetella pertussis vaccine.


Potentiation of the antihypertensive action of hydralazine by timolol in spontaneously hypertensive rats.


Virological investigation of mosquitoes in different seasons of the year at the natural focus of the Tahyna virus in southern Moravia.


To the seasonal occurrence of the virus Tahyna.


The microsporidian Plistophora culicis Weiser, 1946 in different mosquito hosts.


Experimental pneumococcal meningitis I: a rabbit model.


The vector efficiency of Culiseta annulata mosquito in relation to Tahyna virus.


Isolation and characterization of prosthecae of Asticcacaulis biprosthecum.


Uncommon connective tissue disorders in childhood.


The effects of phenothiazines on endocrine function: I. Patients with inappropriate lactation and amenorrhoea.


The effects of phenothiazines on endocrine function: II. Effects in men and post-menopausal women.


Effects of cytosine arabinoside on differential gene expression in embryonic neural retina. I. Accumulation of glutamine synthetase with suppression of macromolecular synthesis. The analogue of cytidine, cytosine arabinoside (Ara-C), elicited a significant increase in the level of glutamine synthetase (GS) in embryonic chick neural retina in the absence of the steroid inducer of the enzyme. The increase was due to de novo synthesis of GS and was mediated by RNA which accumulated in the presence of the effective concentration of Ara-C. Accumulation of GS did not result from the inhibition of DNA synthesis for which Ara-C is best known. This new effect of Ara-C involves differential suppression of macromolecular synthesis in this system: the concentration of Ara-C which caused maximum GS accumulation suppressed overall protein and RNA syntheses 65-75% without inhibiting the transcription and translation of templates essential for GS synthesis. Withdrawal of Ara-C resulted in restoration of RNA synthesis and cessation of GS accumulation, even though preformed templates for the enzyme were present; however, if all RNA synthesis was arrested with actinomycin D at the time of Ara-C withdrawal, GS continued to accumulate. The results are consistent with the hypothesis that Ara-C differentially affects the activity of structural and regulatory genes involved in the regulation of GS levels in the retina: Ara-C allows transcription of the enzyme-specific templates, but reversibly inhibits the expression of regulatory genes which limit the accumulation of GS.


Benzamidopiperidines. 3. Carbocyclic derivatives related to indoramin.


Pheochromocytoma.

Pheochromocytoma.


Studies on biochemical variants of Sh. flexneri. I. Studies on the lactose positive variants of Sh. flexneri 2a.


Studies on biochemical variants of Sh. flexneri. II. Studies on mannitol negative variants of Sh. flexneri 3a.


Antimicrobial spectrum of Triclosan, a broad-spectrum antimicrobial agent for topical application.


Investigations on the mode of action of Triclosan, a broad spectrum antimicrobial agent.


An improved apparatus for separation of mosquito eggs from soil.


Studies on the medical ecological epidemiology in mangrove areas in Thailand.


Review of clinical trials with pipotiazine, pipotiazine undecylenate and pipotiazine palmitate.


Amino acid transmitters in the mammalian central nervous system.


Neuroleptic agents in anesthesia.

Neuroleptic agents in anesthesia.


Nonparalytic poliovirus infections in patients with severe combined immunodeficiency disease.


Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. 18 Carcinogens, including aflatoxin B(1), benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino-trans-stilbene, are shown to be activated by liver homogenates to form potent frameshift mutagens. We believe that these carcinogens have in common a ring system sufficiently planar for a stacking interaction with DNA base pairs and a part of the molecule capable of being metabolized to a reactive group: these structural features are discussed in terms of the theory of frameshift mutagenesis. We propose that these carcinogens, and many others that are mutagens, cause cancer by somatic mutation. A simple, inexpensive, and extremely sensitive test for detection of carcinogens as mutagens is described. It consists of the use of a rat or human liver homogenate for carcinogen activation (thus supplying mammalian metabolism) and a set of Salmonella histidine mutants for mutagen detection. The homogenate, bacteria, and a TPNH-generating system are all incubated together on a petri plate. With the most active compounds, as little as a few nanograms can be detected.


Octopamine: presence in single neurons of Aplysia suggests neurotransmitter function. Octopamine has been identified and measured in individual neurons from Aplysia californica. Neither dopamine nor norepinephrine was detected in these cells. Thus, in Aplysia there may be separate populations of catecholaminergic and monophenolaminergic cells. Octopamine may have functions of its own in the central nervous system of mollusks.


Effects of hypothermia on halothane MAC and isoflurane MAC in the rat.


Involvement of molybdenum and iron in the in vitro assembly of assimilatory nitrate reductase utilizing Neurospora mutant nit-1.


Age bias in referral for psychological consultation.


Transplantation of allogeneic lymphoid cells specifically depleted of graft versus host reactive cells.


Reversal of the perfusion defect in experimental canine lobar pneumococcal pneumonia.


IVMA '74 table topics.

IVMA '74 table topics.


Evidence for the presence of glutamate synthase in extracts of carrot cell cultures.


Functional characteristics of the interneurons of wind-sensitive hair-receptors on the head in Locusta migratoria L. I. Interneurons with excitatory responses.


Functional characteristics of the interneurons of wind-sensitive hair receptors on the head in Locusta migratoria L. II. Interneurons with inhibitory responses.


Studies on the blood sugar level in the grass snake (Natrix natrix L.).


Effect of insulin on the blood sugar level in the grass snake (Natrix natrix L.).


Heart rate and physiological thermoregulation in a basking turtle, Pseudemys scripta elegans.


Observations on extrarenal excretion by orbital glands and osmoregulation in Malaclemys terrapin.


Effects of inorganic anions and cations on oxygen binding of haemoglobin from Arenicola marina (Polychaeta).


Effect of vasotocin and glucagon on plasma growth hormone levels in the pigeon.


Temperature regulation responses of ornate box turtles, Terrapene ornata, to heat.


Catecholamine content and histology of the adrenal glands of the nutria (Myocastor coypus).


The effects of heating and cooling in water on the heart rate of the bullfrog.


Blood glucose in crayfish. II. Variations induced by artificial stress.


Effects of environmental temperature on food intake in growing pigs.


Studies on the red blood cell oxygen affinity and 2,3-diphosphoglyceric acid in the hibernating woodchuck (Marmota monax).


On a peculiarity of planarian digestion.


Adaptation of hepatic phenylalanine hydroxylase in the rat.


Letter: Adverse reactions to beta-adrenergic blockade.


Octopamine: selective association with specific neurons in the lobster nervous system.


Adenylate cyclase activity in lymphoid organs during regional and systemic graft-versus-host reactions.


The HL-A system. I. Genetics and molecular biology.


Immunogenetic disparity and graft-versus-host reactions.


The double barrier in bone marrow transplantation.


Immunosuppression for clinical marrow transplantation.


Bone marrow transplantation in the treatment of acute leukemia.


Histological, histochemical and electron microscopic studies on effects of diphtheria toxin on the adrenals of guinea pigs.


Cellular basis of cardiac dysrhythmias.

Cellular basis of cardiac dysrhythmias.


Comparative studies in vivo and in vitro of rat-liver enzymes.


Cardiac effects of beta-adrenergic receptor antagonists.


The role of nonoxidative metabolism in organophosphorus resistance.


Overcrowding factors of mosquito larvae. V. Synthesis and evaluation of some branched-chain fatty acids against mosquito larvae.


Alteration of tyrosine aminotransferase activity in hepatoma cells in tissue culture by amphotericin B. Two clonal lines of rat hepatoma cells, in tissue culture, that have steroid-inducible tyrosine aminotransferase (TAT) activities were shown to have different responses to amphotericin B. One of the cell lines (HTC) was relatively resistant to the growth-inhibiting effects of amphotericin B and demonstrated an inhibition of only its steroid-inducible TAT activity when exposed to the antifungal agent. In contrast, not only was the other cell line (MHC) sensitive to amphotericin B during its growth, but uninduced and induced enzyme activities were affected. During the first few hours after the exposure of MHC cells to amphotericin B, both basal and dexamethasone-induced TAT activity were reduced; with continued exposure, enzyme activity increased over that of untreated cells and was superinduced in the presence of maximal, stimulating amounts of steroid. The mechanisms by which enzyme activity is induced by amphotericin B are probably different from those mediated by steroids.


Proceedings: A morphological and pharmacological study of the parietal cells of the stomach in the dog during periods of maximal acid output and after the gastric secretory inhibitor UK-9040.


Psychiatric drugs and trends: review of the phenothiazines. 1.


Proceedings: Effect of H2-receptor blockade on vagally induced gastric secretion and gastric emptying in man.


Proceedings: Inhibition of nocturnal acid secretion in duodenal ulcer by oral metiamide.


Proceedings: Initial observations on the inhibitory action of urogastrone on gastric secretory responses in man.


Proceedings: Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease.


Strabismus. Foreword.

Strabismus. Foreword.


Proceedings: Effects on prostaglandin biosynthesis of drugs affecting gastrointestinal function.


The effect of drugs interfering with biogenic amine metabolism on basal gastric secretion in the rat.


The central action of histamine. 3. The effect of antazoline and thenalidine on the brain noradrenaline and 5-hydroxytryptamine levels and behavior of rats receiving histamine intraventricularly.


Solubilization of testosterone 5 alpha-reductase from nuclear fraction of rat ventral prostate.


The effect of silver ions on the respiratory chain of Escherichia coli.


Non-prescription drugs during pregnancy: potential teratogenic and toxic effects upon embryo and fetus.


Presidential adress: Perspectives in pediatrics in India for the seventies.


New concepts in primate production. Report on the Battelle Seattle Research Center Conference, August 11-12, 1972.


Charge transfer interactions of chlorpromazine with neural transmitters.


Stereochemical studies on medicinal agents. 10. The role of chirality in alpha-adrenergic receptor blockage by (plus)-and(minus)-phenoxybenzamine hydrochloride.


The Roberts syndrome.

The Roberts syndrome.


Nitrate reductase from Spinacea oleracea. Reversible inactivation by NAD(P)H and by thiols.


On the conformation of NADP-dependent isocitrate dehydrogenase from Bacillus stearothermophilus.


Reaction of chloroplasts with diazonium-1, 2, 4-triazole.


Emergency treatment for injuries to anterior teeth.


Report of the commission on the armed forces dental services, 1972-1973.


Annual report of the commission on dental practice 1972-1973.


Report of the regional organisation of the F.D.I. for Europe. October 1972-July 1973.


3-Methylcholanthrene-inducible binding of aromatic hydrocarbons to DNA in purified rat liver nuclei.


Letter: Phenothiazines in delirium tremens: pro and contra.


The effects of droperidol on modifying the hypertensive response to ketamine.


Present day management of hypertension.

Present day management of hypertension.


Oxygen effects on mortality of mice infected with Diplococcus pneumoniae.


Evaluation of self-administered prophylaxis and supervised toothbrushing with acidulated phosphate fluoride.


Muscarinic cholinergic binding in rat brain. Binding sites with high affinity and specificity for [(3)H]quinuclidinyl benzilate (QNB) are present in homogenates of rat brain. The characteristics of the binding sites resemble those of muscarinic cholinergic receptors. Specific binding is saturable with respect to [(3)H]QNB and tissue concentration and is time-, temperature-, and pH-dependent. The bimolecular rate of association (2.0 x 10(8) M(-1) min(-1)) and dissociation (1.2 x 10(-2) min(-1)) at 35 degrees indicate a dissociation constant of 60 pM and a density of 65 pmol/g of brain. Muscarinic antagonists and agonists displace specific [(3)H]QNB binding, while nicotinic and non-cholinergic drugs possess little affinity for [(3)H]QNB-binding sites.


Serum complement-fixing antibodies in human dental caries.


G6PD San Jose: a new variant characterized by NADPH inhibition studies.


T-cell-mediated immune responses induced in vitro: a probe for allograft and tumor immunity.


Twenty years of community water fluoridation: the prevalence of dental caries among Providence, R.I. school children.


Antagonism of cardiac arrhythmias by dl-1-(2-acetyl-4-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane (M & B 17,803A), a new beta adrenoreceptor blocking agent.


Cardiovascular effects of dl-1-(2-acetyl-4-butyramido-phenoxy)-2-hydroxy-3-isopropylaminopropane (M & B 17,803A), a new cardioselective beta adrenoreceptor blocking agent.


Studies on enhancement of cardiac and renal allografts in the rat.


Transplantation tolerance and enhancement. Concepts and questions.


Histological study of increased vascular permeability in thermal injury in the sheep.


Effect of acidulated phosphate-fluoride chewable tablets on dental caries in schoolchildren: results after 30 months.


Gamma-glutamyl-transpeptidase in hepato-biliary disease--value as an enzymatic liver function test.


Gas exchange in a cerianthid.

Gas exchange in a cerianthid.


The membrane actions of tranquilizers in relation to neuroleptic-induced parkinsonism and tardive dyskinesia.


Clinical differences among phenothiazines in schizophrenics. Introduction: specific indications for antipsychotics: elusive end of the rainbow.


Pharmacokinetics of 14C-dimethothiazine. I. Distribution and excretion following oral administration in the dog and rat.


Effect of surfactants in the presence and absence of testosterone on the activity of two liver enzymes of tumor-bearing rats.


Proceedings: Studies on cyclic nucleotides in the adrenal gland. V. Adenyl and guanyl cyclase activities in the cortex and medulla of the adrenal gland.


Proceedings: Effects of convalsants and ions in the external solution on invertebrate neuron.


Light-dependent synthesis of glutamate in Rhodospirillum rubrum. Physiological evidence for ammonia assimilation via the glutamine synthetase and glutamine: 2-oxoglutarate amino-transferase system.


Comparison of tyrosine hydroxylase and dopamine-beta-hydroxylase inhibition with the effects of various 6-hydroxydopamine treatments on d-amphetamine induced motor activity.


Proceedings: Antihypertensive action of beta-blockers.


Proceedings: Interaction between possible transmitters and butyrophenones applied microelectrophoretically in the cerebellum and basal ganglia of the cat. 1. Interaction in the purkinje cells of the cat cerebellum.


Proceedings: The effect of alpha-adrenergic blocking agents on hypogastric ganglion from guinea-pig.


Role of beta-receptor vascular tone in the vasodilating action of some drugs.


Characteristics of the nuclear and microsomal steroid delta-4-5 alpha-hydrogenase of the rat prostate.


The feeding response to beta-adrenergic active agents during induced compensatory growth in rats.


Glutathione reductase test with whole blood, a convenient procedure for the assessment of the riboflavin status in humans.


Chemistry and biochemistry of the neomycins. XVI. Synthesis and bioactivity of hexa-N-benzylneomycins.


The effect of endotoxin of Escherichia coli on the graft-versus-host reaction in mice. II. Non-H-2 systems.


The effect of Escherichia coli endotoxin on the graft-versus-host reaction in mice. 3. Runt disease in newborns.


Gamma-glutamyl transpeptidase: a clinical and experimental study.


Granulomatous pulmonary arteritis. A hypereosinophilic syndrome.


Dissociation of catecholamine-induced formation of adenosine 3'5'-monophosphate and release of glycerol in fat cells by prostaglandin E1, E2 and N6-phenylisopropyladenosine.


An evaluation of regulation of the hexose monophosphate shunt in Escherichia coli.


Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Studies of the properties of E3 and its role in the formation of cytidine diphosphate-4-keto-3,6-dideoxyglucose.


On the reaction of piericidin A with the reduced nicotinamide adenine dinucleotide dehydrogenase of Candida utilis.


Malic enzymes of rabbit heart mitochondria. Separation and comparison of some characteristics of a nicotinamide adenine dinucleotide-preferring and a nicotinamide adenine dinucleotide phosphate-specific enzyme.


Effect of tungsten and vanadium on the in vitro assembly of assimilatory nitrate reductase utilizing Neurospora mutant nit-1.


Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. The hisT gene codes for an enzyme responsible for the conversion of uridine to pseudouridine (Psi) in the anticodon region of many tRNA species in Salmonella typhimurium. We have previously shown that a hisT mutant has tRNA(His) which lacks pseudouridine in this region and as a consequence has an altered chromatographic behavior. We show here a similar alteration in chromatographic behavior of all tRNA(Leu) and one tRNA(Ile) species from a hisT mutant. By contrast, tRNA(Val), which contains no pseudouridine except for the one in the TPsiCG sequence, is chromatographically unaltered in a hisT mutant. The absence of pseudouridine in the anticodon region of tRNA in hisT mutants has been previously shown to cause derepression of the histidine operon. We show here that in hisT mutants the regulation of the leucine and the isoleucine and valine operons is also affected: the enzymes of these operons are refractory to repression by the branched chain amino acids. However, there is no difference between hisT and wild type in the pattern of derepression caused by isoleucine or valine limitation and only a slight difference in the enzyme levels in cells grown on minimal medium. The alteration in the regulation of branched chain amino acid operons may also explain why hisT mutants are resistant to inhibition of growth by the amino acid analogues 5,5,5-trifluoroleucine, beta-hydroxyleucine, and norleucine and by the oligopeptides glycylglycylnorleucine and norleucylnorleucine.


Hormonal control of lysosomal enzyme release from human neutrophils: elevation of cyclic nucleotide levels by autonomic neurohormones. The influence of autonomic neurohormones on the immunologic release of beta-glucuronidase (EC 3.2.1.31) from, and the cyclic nucleotide levels in, human neutrophils was determined. Interaction of neutrophils with rheumatoid arthritic, serum-treated zymosan particles in a neutral balanced salt solution at 37 degrees resulted in the extracellular discharge of beta-glucuronidase without any loss of cell viability, as indicated by the failure of incubated cells to take up eosin Y or to release cytoplasmic lactate dehydrogenase (EC 1.1.1.27). Epinephrine reduced the release of beta-glucuronidase from neutrophils in the presence of zymosan during 2-30 min of incubation and elicited a concomitant elevation of adenosine 3':5'-monophosphate levels. Propranolol, a beta-adrenergic receptor antagonist, but not phentolamine, an alpha-adrenergic receptor antagonist, blocked both actions of epinephrine. Acetylcholine stimulated the release of beta-glucuronidase, but not lactate dehydrogenase, and provoked a concomitant elevation of guanosine 3':5'-monophosphate levels. Atropine, a muscarinic receptor antagonist, but not hexamethonium, a ganglionic blocker, inhibited both actions of acetylcholine. Interaction of neutrophils and zymosan particles resulted in an elevation of guanosine 3':5'-monophosphate levels within 2 min. These data suggest that intracellular guanosine 3':5'-monophosphate may be involved in mediating the immunologic release of lysosomal enzymes from human neutrophils whereas adenosine 3':5'-monophosphate may inhibit enzyme release. Moreover, autonomic neurohormones appear to be capable of modulating lysosomal enzyme release by virtue of their capacity to elevate neutrophil cyclic nucleotide levels.


Fluoride uptake and caries inhibition from self-application of an acidulated-phosphate-fluoride prophylaxis paste.


The oscillations of blood pressure in the chicken.


Amounts of inorganic ions and free amino acids in hemolymph and ganglion of the African giant snail, Achatina fulica Ferussac.


Structure-activity relationships of the mitomycins and certain synthetic analogs.


Potential bioreductive alkylating agents. 4. Inhibition of coenzyme Q enzyme systems by lipoidal benzoquinone and naphthoquinone derivatives.


In vitro androgen metabolism in mouse kidney: high 3-keto-reductase (3alpha-hydroxysteroid dehydrogenase) activity relative to 5alpha-reductase.


Insect growth regulators: evaluation procedures and activity against mosquitoes.


Multiple molecular forms of gamma-glutamyl transpeptidase during human pregnancy.


Continuous pH stat assay technique for glutamine and asparagine synthetase enzyme systems, involving ATP conversion to ADP plus Pi and AMP plus PPi, respectively.


Benzamidopiperidines. 2. Heterocyclic compounds related to indoramin.


The barrier function of lymph nodes. A review of experimental studies and their implications for cancer surgery.


The nitroblue tetrazolium test.

The nitroblue tetrazolium test.


Exacerbation of dapsone-induced Heinz body hemolytic anemia following treatment with methylene blue.


Polypodium sp. (Coelenterata) found in North American sturgeon.


Activation of 17beta-hydroxysteroid dehydrogenase from human red blood cells.


Marrow transplants in aplastic anemia and leukemia.


Influence of changes in brain monoamine metabolism on behaviour of herpes simplex-infected mice.


A mechanism of the acceleration of lipid peroxide formation in liver homogenates and subcellular fractions of vitamin E-deficient mice.


Introduction: of syndromes and interfaces.


Ocular manifestations of rheumatic disorders. Natural and iatrogenic.


Glutamine synthetase activity in cat neocortex during the evolution of an ectosylvian spiking focus activated by pentetrazol.


Studies on antihistaminics in acute radiation burn.


The skin as a reflector of immunologic change.


Purification and some properties of gamma-glutamyl transpeptidase from azo dye-induced hepatoma.


Adaptive control of the ethanol-forming system in heterolactic acid bacteria. Effect of growth conditions on alcohol dehydrogenase synthesis in Leuconostoc mesenteroides.


The effect of information and motivation towards dental health, and of fluoride tablets on caries in schoolchildren. I. Increment over the initial 2-year experimental period.


Asian Pacific regional organisation of FDI. Annual report 1972-73.


Mechanism of mercuric chloride resistance in microorganisms. 3. Purification and properties of a mercuric ion reducing enzyme from Escherichia coli bearing R factor.


Effective and practical preventive procedures.


Effect of experimental pneumococcal meningitis on respiration and circulation in the rabbit. Pathophysiological studies in bacterial meningitis in man have been limited by clinical variability and the necessity for immediate therapy. After the development of a reliable animal model of pneumococcal meningitis, we studied respiration and circulation in 25 anesthetized New Zealand white rabbits during untreated pneumococcal meningitis and in 33 healthy controls. In meningitis, we found increased lactic acid in cerebrospinal fluid (CSF). Increased ventilation, perhaps due to CSF lactic acid accumulation, resulted in respiratory alkalosis; the concomitant lowering of Pco(2) acted as a homeostatic mechanism to restore pH toward normality in the CSF. Hyperventilation increased with the duration of the illness. Cardiac output was also increased with decreased peripheral vascular resistance but with only slight reduction in mean systemic and pulmonary arterial pressures. In the final hour of life, peripheral vascular resistance fell further; ventilation declined and then abruptly ceased while cardiac activity continued. Lactic acid accumulation in the CSF, found in both experimental and human pneumococcal meningitis, may cause the hyperventilation found in this disease and may contribute to death.


Letter: Scleroderma and mosquitos.

Letter: Scleroderma and mosquitos.


Transplantation in the military. I. Guidelines for cadaver organ donation.


Fluoride contents of surface enamel in high- and low-fluoride areas studied with a sensitive physical method.


Histotopochemical determination of metabolic activity of carbohydrate metabolism in plaque from sound and carious enamel.


Mechanism of lymphocyte-mediated cytolysis. The LMC cycle and its role in transplantation immunity.


Significant social variables in favorable community adjustment of schizophrenics: a 5-year follow-up.


Letter: Stability of gamma glutamyltransferase in serum.


Letter: Interference from serum separators in drug screening by gas chromatography.


The effect of phenothiazines on botulinus intoxication.


Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity.


Altered glucoregulatory hormones during acute pneumococcal sepsis in the rhesus monkey.


Pertussis vaccine and convulsive disorders of childhood.


Percentage contribution of increased heart rate to increased oxygen transport during activity in Pseudemys scripta, Terrapene ornata and other reptiles.


High capillary permeability in fishes.

High capillary permeability in fishes.


Medical vagotomy: new evidence of its potential usefulness as a preoperative test.


Changes in hypothalamic catecholamines and serotonin during hibernation and arousal in the arctic ground squirrel.


Physiological correlates of burrow gas conditions in the California ground squirrel.


The effect of changes in external salinity on the non-protein nitrogenous constituents of parietal muscle from Agonus cataphractus.


The resting potential of cockroach muscle membrane.


Electrogenesis in cockroach muscle.

Electrogenesis in cockroach muscle.


Regulation of the corticosteroid inducibility of tyrosine aminotransferase in interspecific hybrid cells.


Letter: Trophic effects of striatal neuron denervation.


Pathophsiological significance of sympathetic activity in cardiovascular diseases.


Use of sympathomimetic amines in shock.

Use of sympathomimetic amines in shock.


Proceedings: Neural and humoral control of apocrine glands.


Primary total proctocolectomy for ulcerative colitis.


The urologic allied health professional.


The barefoot doctors of the People's Republic of China--some problems.


Systemic and coronary hemodynamic effects of intracoronary administration of prostaglandins E1 and E2.


Effects of alpha and beta blockers on hemodynamics of SHR.


Review: Electrolyte and antiarrhythmic drug interaction.


Proceedings: Contribution of cardiovascular factors to the development of hypertension in spontaneously hypertensive rats. A preliminary report.


Effect of temperature on histidine ammonia-lyase from a psychrophile, Pseudomonas putida. Pseudomonas putida was able to grow at 0 C in a complex medium containing l-histidine and to synthesize histidine ammonia-lyase and urocanase. The activity of the former enzyme was assessed between -10 and 60 C in cells and in cell extracts. Activity was maximal from 20 to 35 C. Below 20 C, activity decreased with temperature but, significantly, the enzyme exhibited 30% of its maximal activity at 1.5 C. The temperature response was similar in both intact cells and cell extracts, which indicated that the cell membrane did not significantly limit the entry of histidine at low temperature. Above and below the maximal temperature range, the reduced activity was not caused by irreversible inactivation, as shown by preincubation experiments. Also, when the temperature was rapidly changed from 60 to 30 C during an assay, the reaction rate increased abruptly to the full 30 C activity without a lag. This demonstrated the rapid reversibility of inactivation. The apparent Michaelis constant increased with temperature. As the substrate concentration was decreased, the enzyme activity became less dependent on temperature. The efficiency of substrate entry and catalysis near 0 C are factors in the ability of this facultative psychrophile to grow in a histidine medium at 0 C.


Extracellular enzyme secretion by Pseudomonas lemoignei. The ability of succinate to repress the secretion of Pseudomonas lemoignei poly-beta-hydroxybutyrate depolymerase was a function of pH. Repression only occurred when the pH of the medium was 7.0 or less. At a higher pH, lack of sensitivity to succinate concentration may have been due to a limited ability to transport succinate. Actively secreting cultures (at pH 7.4) continued to secrete enzyme for approximately 30 min after the pH was rapidly decreased to pH 6.8, even though sufficient succinate was present to repress enzyme synthesis. Similarly, after the addition of rifampin to secreting cultures, there was a 30-min delay before secretion was inhibited. Evidence is presented which suggests that continued secretion may be the result of depolymerase messenger ribonucleic acid accumulation within the cells. Studies with chloramphenicol indicated that de novo protein synthesis is necessary for the secretion of poly-beta-hydroxybutyrate depolymerase and that exoenzyme is not released from a preformed pool. Studies with various inhibitors of protein synthesis indicated that synthesis of exoenzyme is 5 to 10 times more susceptible to inhibition than is the synthesis of cell-associated proteins.


Causes of the post-concussional syndrome.


Screening of African Strychnos species for convulsant and muscle-relaxant effects.


Isolation and characterization of the outer membrane of Neisseria gonorrhoeae. The cell envelope of Neisseria gonorrhoeae strain 2686, colonial type 4, was isolated from spheroplasts formed by the action of ethylenediaminetetraacetic acid and lysozyme. Isopycnic centrifugation of osmotically ruptured spheroplasts resolved the cell envelope into two main membrane fractions. Chemical and enzymatic analyses were used to characterize these isolated membranes. Succinic dehydrogenase, reduced nicotinamide adenine dinucleotide oxidase, and d-lactate dehydrogenase were localized in the membrane fraction of buoyant density, rho degrees = 1.141 g/cm(3). Lipopolysaccharide and over half of the cell envelope protein were associated with the membrane that banded in sucrose at rho degrees = 1.219 g/cm(3). These fractions were consequently designated cytoplasmic and outer or L-membrane, respectively. Sodium dodecyl sulfate-polyacrylamide electrophoresis of isolated membranes demonstrated the relative simplicity of the protein spectrum of the outer membrane. The majority of the protein in this membrane could be accounted for by proteins of molecular weights 34,500, 22,000, and 11,500. The protein of molecular weight 34,500 accounted for 66% of the total protein of the L-membrane. Isoelectric precipitation at pH 4.6 with 10% acetic acid selectively removed this protein from a 150 mM NaCl in 10 mM tris(hydroxymethyl)aminomethane-hydrochloride, pH 7.4, extract of purified outer membrane. At pH 4.0, the other proteins of the L-membrane were precipitated. It was concluded that the membrane components of the cell envelope of N. gonorrhoeae were similar to those of other gram-negative bacteria. The cell envelope fractions described here, in particular the outer membrane, are sufficiently well defined to provide a valuable tool for future biochemical and immunological studies on N. gonorrhoeae.


Dental health status of Gulf Coast Head Start.


The effect of diet on formation of gamma-glutamyl transpeptidase (GGTP) inhibitor in the mouse intestine.


Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects.


Influence of althesin on coronary blood flow and myocardial oxygen consumption in dogs.


Enzymes of the gamma-glutamyl cycle in the ciliary body and lens. The enzymes of the gamma-glutamyl cycle have been found in rabbit ciliary body and, except for 5-oxoprolinase, also in the ocular lens. Histochemical studies show that gamma-glutamyl transpeptidase is localized mainly in the basal portions of the epithelial cells of the ciliary body; the findings are similar to those observed in the chloroid plexuses. The histochemical staining reaction in the ciliary epithelium is more intense than in the chloroid plexus, intestine, and kidney. gamma-Glutamyl transpeptidase staining activity in the epithelium of the intestinal and renal proximal convoluted tubules is confined to the microvillus border. Moderate transpeptidase activity was found in the cytoplasm of nonpigmented epithelial cells of the iris at the posterior pupillary margin. The histochemical and enzyme activity studies are consistent with the thesis that the gamma-glutamyl cycle functions in transport of amino acids across the blood-aqueous humor barrier.


D-(R)- and L-(S)-3-alkylaminopyrrolidino-substituted dihydrodibenzo (b,f)- and-(b,e)thiepins, xanthenes, and diphenylmethanes.


A simple, rapid method for detecting the efflux of small quantities of adenosine triphosphate from biological tissues.


The salt relations of marine and halophilic species of the unicellular green alga, Dunaliella. The role of glycerol as a compatible solute.


Orientation of membrane vesicles from Escherichia coli prepared by different procedures.


On the acrylamide disc electrophoresis pattern of human G6PD.


Sympathetic ganglia in organ culture.

Sympathetic ganglia in organ culture.


The development of catecholaminergic neurons of the central nervous system.


The benefits of water fluoridation.

The benefits of water fluoridation.


Amoxicillin in the treatment of respiratory infections.


Distribution of the sensitivities to penicillin of types of Diplococcus pneumoniae in an American Indian population.


Studies on metabolic events in localized compartments of the living cell by rapid microspectrofluorometry.


Effect of sweets made with and without sucrose on the dental plaque, and the correlation between the extent of plaque and human dental caries experience.


Noradrenaline nerve terminals in the cerebral cortex: effects on noradrenaline uptake and storage following axonal lesion with 6-hydroxydopamine.


Letter: Fenticlor, actinic reticuloid, and antihistamines.


Letter: Beta-blockade in the presence of renal disease and hypertension.


Bone marrow transplantation in aplastic anaemia.


Attempts at altering ureteral activity in the unanesthetized, conditioned dog with commonly employed drugs.


Cell-mediated reactivity and serum blocking activity in tolerant rats. Studies on ten rats operationally tolerant to skin allografts using several independent assays.


Coordinate control of rat liver lipogenic enzymes by insulin.


Specific protein metabolism in identifiable neurons of Aplysia californica.


Catecholamine systems as the neural substrate for intracranial self-stimulation: a hypothesis.


Amino acid levels in liver and plasma of the rat during inhibition of transamination.


Dimensional changes in a fixed bridge as a consequence of four different assembly technics for soldering purposes.


Histology and histochemistry of the peripheral neural plexus in the Aplysia gill.


Effects of long-term organ culture on neurotransmitter metabolism in the ganglia of Aplysia californica.


Prevention of injuries to anterior teeth.


Proceedings: an attempt to estimate the sympathetic activity to the heart of man in his home environment.


Acute arterial occlusion in the upper limbs. A follow-up study of 31 extremities.


Prevalence of dental caries in phenylketonuric children.


Prequalene pyrophosphate. A normal intermediate in squalene biosynthesis.


Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose.


Localization of some enzymes in the main venom glands of viperid snakes.


Reduced nicotinamide adenine dinucleotide dehydrogenase, piericidin sensitivity, and site 1 phosphorylation in different growth phases of Candida utilis.


Cyclic AMP and adrenergic receptors in Gambusia affinis melanophore response in vitro.


Comparative study of two beta-adrenergic blocking drugs in angina pectoris.


Effects of temperatures and activity on aerobic and anaerobic metabolism and heart rate in the turtles Pseudemys scripta and Terrapene ornata.


Hemolymph DNA concentrations during the molting cycle of the fresh water crayfish, Procambarus clarkii.


Increase of Na-K-ATPase activity in renal cortex of hamster (Mesocricetus auratus) during pre-hibernation cold exposure.


Melanophore aggregation in the plaice (Pleuronectes platessa L.) I. Changes in vivo sensitivity to sympathomimetic amines.


Melanophore aggregation in the plaice (Pleuronectes platessa L) II. In vitro effects of adrenergic drugs.


Facilitated diffusion in erythrocytes of mammals.


Neonatal 6-hydroxydopamine sympathectomy in normotensive and spontaneously hypertensive rat.


Salbutamol and quinterenol: dipsogenic action produced by beta-adrenergic stimulants.


Sar1-Ala8 angiotensin II blocks renin-angiotensin but not beta-adrenergic dipsogenesis.


Neurochemical bases of defensive behavior in animals. This paper presents a literature review and the author's own investigations devoted to identifying the morphological organization of different subcortical structures and neurochemical processes involved in the (regulation of defensive behavior. The effects of intrahypothalamic injections of two cholinomimetic substances, carbachol and d-tubocurarine, on rage and fear reactions were explored. Also the investigations were carried out with intrahypothalamic injections of anticholinergic substances, atropine and betamon or hexamethonium, which block selectively muscarinic and nicotinic receptors. The results indicate that carbachol injected into the hypothalamus after blocking the muscarinic receptors with atropine fails to elicit any defensive response; whereas carbachol injection administrated after nicotinic receptors had been blocked by betamon or hexamethonium induces full aggressive behavior. This indicated that carbachol acts, on the hypothalamic level, through the muscarinic receptors. The mechanism of d-tubocurarine action seems to be more complex because this compound induces fear response after either the muscarinic or the nicotinic receptors have been blocked. A possible mechanism based on chemically differentiated neuronal circuits at the hypothalamic level for two different defensive drives, fear and rage, is presented.


A new antihistaminic drug (Tavegyl) in allergic diseases.


Major tranquillizers in the management of psychasthenic neurosis.


Proceedings: Some morphologic and pharmacologic observations on the apocrine glands in the tail of the goat.


Effects of oxygen and glucose on energy metabolism and dimorphism of Mucor genevensis grown in continuous culture: reversibility of yeast-mycelium conversion. Mucor genevensis was grown in both glucose-limited and glucose-excess continuous cultures over a range of dissolved oxygen concentrations (<0.1 to 25 muM) to determine the effects of glucose and the influence of metabolic mode (fermentative versus oxidative) on dimorphic transformations in this organism. The extent of differentiation between yeast and mycelial phases has been correlated with physiological and biochemical parameters of the cultures. Under glucose limitation, oxidative metabolism increased as the dissolved oxygen concentration increased, and this paralleled the increase in the proportion of the mycelial phase in the cultures. Filamentous growth and oxidative metabolism were both inhibited by glucose even though mitochondrial development was only slightly repressed. However, the presence of chloramphenicol in glucose-limited aerobic cultures inhibited mitochondrial respiratory development but did not induce yeast-like growth, indicating that oxidative metabolism is not essential for mycelial development. Once mycelial cultures had been established under aerobic, glucose-limited conditions, subsequent reversal to anaerobic conditions or treatment with chloramphenicol caused only a limited reversal (<35%) to the yeast-like form. Glucose, however, induced a complete reversion to yeast-like form. It is concluded that glucose is the most important single culture factor determining the morphological status of M. genevensis; mitochondrial development and the functional oxidative capacities of the cell appear to be less important factors in the differentiation process.


Studies on D-tetrose metabolism. IV. Purification and some properties of D-erythrulose reductase from beef liver.


Cholesterol and cholesterol sulfate as substrates for the adrenal side-chain cleavage enzyme.


Catalysis of pentose phosphate pathway reactions by cytoplasmic fractions from muscle, uterus and liver of the rat, and the presence of a reduced nicotinamide-adenine dinucleotide phosphate-triose phosphate oxidoreductase in rat muscle. 1. The enzymes of the pentose phosphate pathway were assayed in supernatant fractions from rat muscle, liver and uterus. 2. On incubation of ribose 5-phosphate with uterus and liver supernatants, triose phosphate, sedoheptulose 7-phosphate and hexose monophosphate accumulated. 3. When a muscle supernatant was used, glycerol 3-phosphate instead of triose phosphate appeared and there was a negligible accumulation of hexose monophosphate. 4. Hexose monophosphate production from ribose 5-phosphate was also followed by measuring NADP(+) reduction in the presence of an excess of phosphoglucose isomerase, glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. 5. With a muscle supernatant, NADPH was reoxidized as rapidly as it was formed owing to the presence of a NADPH-triose phosphate oxidoreductase. 6. A modification of the pentose phosphate pathway in skeletal muscle incorporating this enzyme is proposed.


Actions of metiamide, an H2-histamine receptor antagonist, on gastric H+ and pepsin secretion in dogs.


Evidence of the direct aromatization of testosterone and different aromatization sites for testosterone and androstenedione in human placental microsomes.


Role of mosquitoes in transmission of hepatitis B virus infection.


Comparison of ampicillin and amoxicillin in the treatment of otitis media in children.


Middle ear infections in pediatric patients: treatment with amoxicillin.


Treatment of otitis media in pediatric practice: amoxicillin versus ampicillin.


Infections of the lower respiratory tract: treatment with amoxicillin.


Amoxicillin in infections in patients with cancer.


Selectivity of interferon action: hormonal induction of tyrosine aminotransferase in rat hepatoma cells is much less sensitive to interferon than the replication of vesicular stomatitis virus or reovirus.


The relative significance of CO2-fixing enzymes in the metabolism of rat brain.


Adenylate cyclase in a sea anemone. Implication for chemoreception.


Letter: Beta-blockade in the presence of renal disease and hypertension.


A 4-year follow-up of vulnerable adolescents. The prediction of outcomes in early adulthood from measures of social competence, coping style, and overall level of psychopathology.


Effects of a synthetic estrogen upon steroid bioconversion in vitro in testes of patients with prostatic cancer.


Interspecific variability of soluble isocitrate dehydrogenase in primates.


Futher studies on the nature of phenylalanine hydroxylation in brain.


Cyclic nucleotide metabolism in human photoreceptors.


Interactions of Ca, P, Zn and alkaline phosphatase in the chick. 3. Effects of dietary phosphate, NaCl and theophylline.


Regulation of plasma Na+ and K+ concentrations in five African species of Tilapia fishes.


Oxygen equilibria of the vascular and coelomic hemoglobins of the terebellid polychaete, Pista pacifica. Evidence for an oxygen transfer system.


Beta-adrenergic receptor blocking drugs in hypertrophic cardiomyopathy, autonomically mediated cardiovascular functional disorders and Fallot's tetralogy.


The detection of Klinefelter's syndrome at birth.


m-Hydroxybenzoate 4-hydroxylase from Aspergillus niger: purification and properties.


Synthesis of fatty acids from malonyl-CoA and NADPH by pigeon liver fatty acid synthetase.


NADP+-specific isocitrate dehydrogenase of Escherichia coli. II. Subunit structure.


Some new paramagnetic centers in submitochondrial particles detectable by EPR spectroscopy.


Summary and recommendations of the workshop on cancer detection in the health care delivery system.


Adaptive response of hepatic acetyl-CoA carboxylase to dietary alterations in genetically obese mice and their lean controls.


Male infertility. Current diagnosis and treatment.


Chlorpropamide overdosage: delayed and prolonged hypoglycemia.


Proceedings: Hazards of maternally administered drugs.


Editorial: The pharmacology and therapeutic use of beta-adrenergic receptor blocking drugs in cardiovascular disease.


Glutamic acid: selective depletion by viral induced granule cell loss in hamster cerebellum.


Pathway of infection of mosquito iridescent virus. I. Preliminary observations on the fate of ingested virus. Mosquito iridescent virus (MIV) is ingested in large amounts by first- and second-instar Aedes taeniorhynchus larvae without causing a high rate of infection. Electron microscope studies have been undertaken to determine the fate of ingested virus. Preliminary observations suggest that most, if not all, ingested particles are degraded shortly after entering the midgut. MIV and other virus particles employed in this study were apparently unable to penetrate the peritrophic membrane; consequently, none was observed inside, or in contact with, midgut epithelial cells.


Beta-adrenergic receptor blocking drugs in hypertension.


Chromatography of cell suspensions: a simple method for the determination of pyridine nucleotides.


The relationships between measures of general depression and the endogenous versus reactive classification.


Studies of the metabolism of carbon disulfide by rat liver microsomes.


Letter: Piperacetazine-induced failure to ejaculate.


Metabolic adaptations in fatty acid and lactose biosynthesis by sheep mammary tissue during cessation of lactation.


Glutamine synthetase of Bacillus stearothermophilus. I. Purification and basic properties.


Nuclear magnetic resonance study of the complexes of manganese(II) and fully adenylated glutamine synthetase (Escherichia coli W). Frequency, temperature, and substrate dependence of water proton relaxation rates.


Mechanism of the luminescent intramolecular reaction of aequorin.


Immunologic modification: a basic survival mechanism.


Evidence for circulation of Sindbis virus and other arboviruses by using sentinel animals in Western Slovakia.


Potentiation of the antiinflammatory action of prednison by several synthetic antihistaminics.


Some properties of erythrocyte glucose-phosphate dehydrogenase in psoriatics.


The lonely legend of Norman Bethune.

The lonely legend of Norman Bethune.


Acute respiratory insufficiency and cor pulmonale. Pathophysiology, clinical features, and management. II. Management.


The pharmacology of severe bronchial asthma.


Relationships of psychological dimensions to impairment in a population with cerebrovascular insufficiency.


Liver structure and function in cholelithiasis: effect of chenodeoxycholic acid. Although, in suitable patients, oral chenodeoxycholic acid (CDCA) dissolves gallstones, the results of recent animal studies suggest that it might be hepatotoxic. Liver function was therefore studied in patients with gallstones before and during treatment with CDCA and liver biopsies were carried out both in patients with cholelithiasis given bile acid therapy and in those who had been given no medical treatment. In 25 patients treated with 0.5-1.5 g CDCA/day (7-20 mg kg body weight(-1) day(-1)) there was no significant change in serum bilirubin, albumin, globulin, transaminase, isocitric dehydrogenase, alkaline phosphatase, and gamma glutamyl transpeptidase levels before and at monthly intervals during six months' treatment. The kinetics of bromsulphthalein (BSP) clearance and its apparent transport maximum were not significantly changed during CDCA therapy. The mean fasting serum bile acid concentrations of 18.0 +/- SEM 1.2 mumoles/litre before and 20.0 +/- 3.5 mumoles/litre during treatment were both significantly greater than control values. Liver histology was not appreciably different in 11 patients treated with CDCA from that in eight patients with untreated cholelithiasis and in three patients who had received CDCA three to four months before biopsy. These results suggest that in doses of 0.5 to 1.5 g/day CDCA is not hepatotoxic in man.


Uterine pressures during fluroxene anesthesia.


The influence of radiation on blood vessels and circulation. Chapter X. Blood flow and permeability in irradiated skin.


Endocrine variations in the course of the immunologic process, from its onset to its extinction, and the relationship to the nervous system type.


Dobutamine, a new beta agonist.

Dobutamine, a new beta agonist.


Blockade of insulin release by certain phenothiazines.


Modified system in vitro for the metabolism of 2-acetylaminofluorene.


Methylprednisolone acetate and its use in the treatment of students with hay fever at examination time.


T cell response to viral and bacterial infection.


Immunity to infection, allograft immunity and tumour immunity: parallels and contrasts.


Topographical definition of new sites on the mitochondrial electron transport chain.


American Nurses' Association: Convention '74.


Role of a deoxyribonuclease in the genetic transformation of Diplococcus pneumoniae. Two steps in the uptake of DNA by Diplococcus pneumoniae were characterized by analyzing mutants defective in transformation. A strain deficient in the two major deoxyribonucleases of D. pneumoniae takes up DNA normally and converts it to single strands within the cell and oligonucleotide fragments outside the cell. Extracts of this strain contain a residual deoxyribonuclease that produces similar oligonucleotide fragments in vitro. This enzyme is missing in transformation-defective mutants blocked in the second or entry step. Cells of this mutant class bind large amounts of DNA to their surface in a form accessible to external agents. Another class of nontransformable mutants fails to bind DNA at all. Their deoxyribonuclease content is unchanged, and they are apparently blocked in the first or binding step of DNA uptake. The binding step requires a source of energy and prior activation of the cells by competence factor. Entry may be independent of these requirements and may come about by action of the deoxyribonuclease on one strand of DNA with energy for the transport of the intact strand deriving from hydrolysis of the degraded strand. The enzyme may thus act as a DNA translocase.


Protection of lethally irradiated mice by spleen cells from neonatally thymectomized mice. Long-lived, immunologically vigorous (C3H(f) x A(f))F(1) hybrids were produced after lethal irradiation by administration of spleen cells from C3H(f) or syngeneic donors. Further, neonatally thymectomized C3H(f) or A(f) strain donors reconstituted irradiated C3H(f) or (C3H(f) x A(f))F(1) hosts. In addition, C3H(f) spleen cells from nonthymectomized 10- to 15-day-old donors protected irradiated hybrid mice, but A(f) cells of young mice as well as of older mice produced graft-versus-host reaction and early death in irradiated C3H(f) or (C3H(f) x A(f))F(1) hybrids. Abrogation of secondary disease by treatment of irradiated mice with spleen cells from allogeneic neonatally thymectomized mice is possibly attributable to diminished immunologic competence of the cells grafted, followed by the development of immunological tolerance of the donor cells. Donor cells, receiving thymus influence in the recipient host after transplantation, could explain the long-lived immunologically vigorous radiation chimeras that did not experience graft-versus-host reactions. The findings of this study help to understand the differential susceptibility of A(f) and C3H(f) mice to development of tolerance to one another's antigens observed in prior investigations. It appears that, in these mice, the host thymus influences the maturation of the spleen cells from young mice or from neonatally thymectomized mice. However, this influence was often greater in mice given 767 rads than in those given 1046 rads. This differential influence is possibly attributable to irradiation damage to the thymus produced by the higher dose of irradiation. Spleen cells from neonatally thymectomized mice can be differentiated and expanded by the thymus of the host. The differential susceptibility of T(1), early differentiation stages, of thymus-dependent lymphocytes and T(2), late differentiation stages, of thymus-dependent lymphocytes to tolerance induction and immunostimulation, respectively, are proposed as the bases for these otherwise paradoxical influences.


Enzymatic aziridine synthesis from beta amino-alcohols--a new example of endogenous carcinogen formation.


H2-receptors in peripheral blood vessels.


Rat liver D-amino acid oxidase activity in iron deficiency anemia.


Pitfalls in the study of steady state kinetics of enzymes: spurious inhibition patterns due to stray light errors.


Studies on enzyme reactions related to steroid biosynthesis. 3. Distribution of the testicular enzymes related to androgen production between the seminiferous tubules and interstitial tissue.


Kinetics of glucose-6-phosphate dehydrogenase from normal and neoplastic mammary tissue.


Lymphocyte plasma membranes. I. Thymic and splenic membranes from inbred rats.


The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro. Burimamide, an H(2)-receptor blocking agent, has been shown capable of blocking the uptake and metabolism of [(14)C]-histamine, both in the guinea-pig isolated atrium and in murine neoplastic mast cells. This occurs even at concentrations far below the dose range capable of blocking the positive chronotropic effect of histamine in the isolated atrium. In the atrium, very low concentrations of burimamide were found capable of blocking histamine metabolism.


On the pharmacology and biochemistry of the amine-uptake mechanism in human blood platelets. 1. The uptake of 5-hydroxytryptamine (5-HT) by human blood platelets in vitro has been studied with the object of identifying the biochemical mechanisms involved.2. Drugs active in adrenergic systems are only moderate inhibitors of uptake, although prenylamine is as active as the less potent tricyclic anti-depressive drugs; phenoxybenzamine is almost inactive as a competitive inhibitor but is effective if pre-incubated with the platelets beforehand. This parallels its pharmacological pattern of action.3. Inhibitors of oxidative phosphorylation do not inhibit 5-HT uptake, but iodoacetate inhibits, if pre-incubated with the platelets; p-chloromercuribenzoate does also, when the platelets are suspended in synthetic medium, but not in plasma.4. Ouabain causes significant inhibition at 10(-7)M; by 10(-6)M it achieves its maximal effect, namely 40% inhibition; in K(+)-deficient medium, uptake falls to 30% of normal; the K(+)-dependent fraction of the uptake includes the ouabain-sensitive component. Mg(++) has no effect.5. A drug not possessing the imipramine structure, which has been tried in the treatment of depressive illness, 4-phenyl bicyclo (2,2,2) octan-1-amine, is a highly potent inhibitor of 5-HT uptake.


Bacteriocidal properties of a class of quinoid compounds related to sporulation in the mushroom, Agaricus bisporus. A small phenolic compound, gamma-L-glutamyl-4-hydroxybenzene, and several quinoid derivatives appear in the gill tissues of the mushroom, Agaricus bisporus, during the prodromal period of sporulation. These quinoids markedly inhibit respiratory enzymes and protein synthesis. The temporal relationship of their appearance to sporulaton and their properties as metabolic inhibitors indicate that they initiate and maintain the dormant or cryptobiotic state of the spore. In very low concentrations, these quinoids show significant bacteriocidal action against a variety of microorganisms. The therapeutic potential of these antibiotic properties is considered.


Histoenzymatical approach to the chemoarchitectonics of the basal nuclei in the developing rat brain.


Lysosomal physiology in Tetrahymena. IV. Effect of dichloroisoproterenol on the intracellular source of released acid hydrolases.


Trustees, administration and medical staff interaction: a triangle for hospital management.


Confidentiality of medical records.

Confidentiality of medical records.


A tool for innovative administration: management by objectives.


Assessment and placement service: a key to successful bed utilization.


Block scheduling of diagnostic services.


APS: the Hamilton model.

APS: the Hamilton model.


Pharmacare--a route to cheaper drugs.

Pharmacare--a route to cheaper drugs.


Editorial: Management of childhood asthma.


Effects of 2,2'(methylenediimino)bis-1,3,4-thiadiazole (NSC-143019) on tumor growth and immune responses in mice.


Accumulation of tyrosine hydroxylase molecules during growth and development of the superior cervical ganglion.


Lactoperoxidase-catalyzed iodination of chloroplast membranes. I. Analysis of surface-localized proteins.


Trophic functions of the neuron. II. Denervation and regulation of muscle. The use and abuse of muscle histochemistry.


Trophic functions of the neuron. VI. Other trophic systems. The role of the nerve growth factor in the development of sensory and sympathetic ganglia.


Amino acid flux and protein synthesis after exposure of rats to either Diplococcus pneumoniae or Salmonella typhimurium. At 26 h after inoculation of rats with Diplococcus pneumoniae, the serum concentrations of 10 and 20 individual amino acids were lower than corresponding values observed in pair-fed controls. In contrast, only 2 of 20 serum amino acids were similarly decreased in rats inoculated with Salmonella typhimurium. Despite these serum differences, a greater accumulation of labeled non-metabolizable amino acids occurred in the livers of rats infected with S. typhimurium. These data suggested a greater increase in the flux of amino acids from muscle to liver in the rats infected with S. typhimurium as compared to those infected with D. pneumoniae. A similar increase in serum protein synthesis was observed in rats infected with D. pneumoniae or S. typhimurium. However, with the latter infection, a larger percentage of the amino acids appeared to be utilized as a source of energy in addition to their role as precursors of proteins.


The feasibility of an assistant to the physician.


Effects of 8-azaguanine on the induction of uterine glucose-6-phosphate dehydrogenase activity by estradiol or NADP plus.


Glutamine synthetase of Bacillus stearothermophilus. II. Regulation and thermostability.


Human erythrocyte glucose 6-phosphate dehydrogenase. Content of bound coenzyme.


Location of an isoproterenol-responsive cyclic AMP pool in adrenergic nerve cell bodies and its relationship to tyrosine 3-monooxygenase induction. To decide whether adenosine 3':5'-cyclic monophosphate (cyclic AMP) plays a role as a second messenger in the trans-synaptic induction of tyrosine 3-monooxygenase (EC 1.14.16.2), it is desirable to discriminate between neuronal and extraneuronal changes in cyclic AMP concentration. Treatment of newborn rats with nerve growth factor antiserum or 6-hydroxydopamine, leading to destruction of 61-85% of the adrenergic nerve cell bodies in the superior cervical ganglion, led to a decrease in cyclic AMP of only 16-28%. This observation demonstrates that a relatively small portion of cyclic AMP is localized in the adrenergic neurons. However, administration of isoproterenol produced an increase (12-fold) in cyclic AMP only in this neuronal pool. Neither single nor repeated injections of isoproterenol led to induction of tyrosine monoxygenase. This, together with previous observations that experimental conditions leading to induction of the enzyme do not produce significant increases of cyclic AMP in the whole ganglion, is taken as an indication that cyclic AMP is not acting as a second messenger in the trans-synaptic induction of tyrosine monooxygenase in the rat superior cervical ganglion. In the rat adrenal medulla, treatment with reserpine led to both a shortlasting (60-90 min) increase in cyclic AMP and a subsequent induction of tyrosine monooxygenase. However, the increase in cyclic AMP was almost completely prevented (40 compared to 320%) by pretreatment of the rats with propranolol while the induction of tyrosine monooxygenase was not diminished. This observation also argues against an exclusive key-function of cyclic AMP in trans-synaptic induction of tyrosine monooxygenase in the adrenal medulla.


Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria). Enzyme studies on placenta, cultured skin fibroblasts, and erythrocytes from two sisters with the inborn error 5-oxoprolinuria (pyroglutamic aciduria) indicate that the metabolic lesion in this disease is at the glutathione synthetase (EC 6.3.2.3) step of the gamma-glutamyl cycle. Excessive urinary excretion of 5-oxoproline by these patients appears to be associated with increased synthesis of gamma-glutamyl-cysteine and formation of 5-oxoproline from this dipeptide. Thus, 5-oxoproline is produced in amounts that exceed the normal capacity of 5-oxoprolinase to convert it to glutamate. The data indicate that it may be possible to identify individuals who are heterozygous for this trait by determinations of erythrocyte glutathione synthetase.


Selection for neuroblastoma cells that synthesize certain transmitters. A selection procedure was devised for neurons and related cells that depends upon the ability of the cells to synthesize certain amine neurotransmitters. The rationale for selection is that tyrosine is an essential amino acid for most mammalian cells and that three enzymes from mammalian sources can catalyze the synthesis of tyrosine: phenylalanine hydroxylase (EC 1.14.16.1), tyrosine hydroxylase (EC 1.14.16.2), and tryptophan hydroxylase (EC 1.14.16.4). Tyrosine hydroxylase is found predominantly in adrenergic neurons and related cells that synthesize dopamine, norepinephrine, and epinephrine, and tryptophan hydroxylase in cells synthesizing serotonin or melatonin. Only 1 out of 70,000 uncloned mouse neuroblastoma cells grew well in the absence of tyrosine. Approximately 50% of the cell lines obtained by selection had tyrosine hydroxylase activity. This selection procedure thus provides a simple means of obtaining cell lines of neural origin on the basis of their ability to synthesize putative transmitters.


Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves. Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.


A study of compounds which initiate and block nerve impulses in the perfused rabbit liver. 1. A technique for the perfusion of the rabbit liver with Krebs solution is described: the hepatic nerves were monitored for centripetal action potentials. Spontaneous afferent activity, and a good response to stimulating agents persisted for 7 h or longer.2. Action potentials were elicited by injections or infusions of acetylcholine, 5-hydroxytryptamine, bradykinin, phenyldiguanide, adrenaline and various other compounds. From comparison with experiments carried out in vivo by other authors, it would appear that most of the nerves stimulated were afferent.3. Inhibition of action potentials, either those occurring spontaneously or those elicited by injections, was produced by aspirin, paracetamol, mepyramine, chlorpheniramine, procaine and lignocaine but not by morphine or atropine. Pentolinium produced some inhibition, as did hexamethonium in concentrations of about 7.5 mug/ml.4. Three methods for using the preparation for the assessment of local anaesthetic action are described.5. Lobeline, potassium cyanide and 2,4-dinitrophenol stimulated nerve bundles which were not stimulated by anoxia or hypoxia.


Some effects of burimamide on the isolated perfused pulmonary circulation of the guinea-pig. Infusions of burimamide were found to potentiate the pressor response to histamine and abolish the depressor response to histamine in the presence of mepyramine, in the isolated perfused guinea-pig pulmonary circulation. It is concluded that the depressor response to histamine is due to stimulation of histamine H(2)-receptors in the pulmonary vessels.


The effects of a new alpha- and beta-adrenoceptor antagonist (AH5158) upon the general and coronary haemodynamics of intact dogs. AH5158, a salicylamide derivative, said to be a blocker of alpha- and beta-adrenoceptors, has been studied in intact anaesthetized dogs. At a dose of 2.5 mg/kg intravenously, the drug increased cardiac output and caused a late fall in mean systemic and pulmonary arterial pressure. Coronary sinus flow increased, as did cardiac oxygen extraction. External cardiac efficiency decreased. Blood glucose and non-esterified fatty acid values increased, but cardiac extraction of these did not change.


Electron-microscopic heterogeneity of onion-bulb neuropathies of the Déjerine-Sottas type. Two patients in one family with the variant described by Lyon (1969).


Meningitis and bacteremia due to Haemophilus influenzae: occurrence and mortality at Boston City Hospital in 12 selected years, 1935-1972.


Influence of disulfiram and sodium diethyldithiocarbamate on pressor response to tyramine in reserpinized rats.


Selective stimulation of a cellular immune response by methotrexate.


Bacterial meningitis in Bernalillo County, New Mexico: a comparison with three other American populations.


Vascular lesions in acute electric injuries.


"Biogenic" aldehyde metabolism relation to pentose shunt activity in brain.


Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).


The effect of lipid phase transitions on the architecture of bacterial membranes.


Prolonged survival in long-passage AKR leukemia using chemotherapy, radiotherapy, and adoptive immunotherapy.


Effects of age and years of exposure on the economic benefits of fluoridation.


Adenotonsillectomy as the treatment of serious medical conditions: five case reports.


Collagenous sprue.

Collagenous sprue.


Abscesses of the head and neck.

Abscesses of the head and neck.


Trophic functions of the neuron. II. Denervation and regulation of muscle. The correlation of physiological properties with histochemical characteristics in single muscle units.


Mucociliary function of the respiratory tract as influenced by drugs.


Physicians' fee schedule is a deterrent to quality care.


P.E.I. leads east coast hospitals: inservice education on team concepts.


The European approach to food service.

The European approach to food service.


H.M.R.I. (Hospital Medical Record Institute)? P.A.S. (Professional Activity Study)? A comparison and evaluation of two automated systems.


The "fatigue factor" in drug addiction: insufficient motivation for treatment.


Phylogenetic distribution of opiate receptor binding.


Lymphocyte deactivation by (potential immunosuppressant) alkylating metabolites of cyclophosphamide.


Fibrosing alveolitis and treatment with sulphasalazine. A woman with ulcerative colitis was treated with sulphasalazine and prednisolone. After four months' treatment she began to get short of breath and she died a month later with severe subacute fibrosing alveolitis. It is believed that the lung disease was caused by sulphasalazine and that prednisolone was not able to prevent its development. A reversible form of lung disease has previously been attributed to this drug.


Amine-induced influence on spontaneous ovarian contractility in the guinea pig and the cat.


The inhibitory effect of Ritodrine on human tubal activity in vivo. The effect of Ritodrine (4-hydroxy alpha-1-2-4-hydroxyphenyl ethylamino acetylbenzyl alcohol hydrochloride) on fallopian tubal activity was studied in 26 women of reproductive age who underwent abdominal surgery for tuboplasty (8 women),  tubal ligation (6 women), or ovarian or uterine pathology (12 women).  Tubal mobility was recorded by the intratubal microballoon method.  Ritodrine was given intravenously at infusion rates of 50-600 mcg/minute or orally.  At infusion rates of 200-300 mcg/minute, Ritodrine suppressed the spontaneous outbursts of increased activity, but tubal quiescence was achieved only at infusion rates of 400 mcg/minute or higher.  Oral administration of 5-10 mg of Ritodrine was insufficient to depress motility, however 15-20 mg achieved quiescence lasting longer than 1 hour.  It was suggested that it is conceivable that the administration of a beta-adrenergic activator such as Ritodrine at appropriate times of the menstrual cycle would interfere with conception through inhibition of the ovum retention mechanism in  the tube.


Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action. Interaction of 21 benzodiazepines with the glycine receptor in the brainstem and spinal cord of rat have been evaluated in terms of their displacement of [(3)H]strychinine binding. The rank order of potency of the 21 drugs in displacing specific [(3)H]strychinine binding correlates (p < 0.005) with their rank order of potency in a vareity of pharmacological and behavioral tests in humans and animals that predict clinical efficacy. There is a 50-fold variation in potency of the series of benzodiazepines with mean effective dose (ED(50)) values ranging from 19muM to > 1000 muM. Diazepam (Valium(R)) and chlordiazepoxide (Librium(R)) have ED(50)'s of 26 muM and 200 muM, respectively, whereas the ED(50) for glycine is 25 muM. The inhibitory effects of 10 of the agents in two other central nervous system membrane receptor assays, for the opiate receptor and the muscarinic cholinergic receptor, do not correlate with any of the in vivo pharmacologic and behavioral tests. The benzodiazepines may exert their antianxiety, anticonvulsant and muscle-relaxant effects by mimicking the effects of the neurotransmitter glycine at its central nervous system receptor sites.


Mineral composition of normal human enamel and dentin and the relation of composition to dental caries. II. Microminerals.


Editorial: A proposal for marriage viewed with suspicion.


The local graft versus host reaction in the rat as a tool for drug mechanism studies. 1. A local graft versus host reaction in rats permits the evaluation of drug action on (i) donor (parental) animals and (ii) recipient animals (F(1) hybrid) prior to establishing a lymphoid cell graft to detect drugs which might attenuate immunocompetence over a prolonged period (e.g. steroids).2. Treatment of the recipient animals after a lymphoid graft readily detects anti-proliferative agents and may disclose other agents which interfere with the recognition of non-self by viable graft cells.3. Treatment of the cell graft in vitro before innoculation into the recipient animal permits the detection of alkylating agents, which effectively deactivate graft cells at non-toxic concentrations.4. Examples are given of how this reaction may be used to evaluate functionally the effects of chemical modification of the cell surfaces of lymphocytes and to detect active metabolites generated from a precursor drug (e.g. cyclophosphamide).5. Some novel immunosuppressant drugs are described.


Sucrose taste sensitivity in Canadian Inuit and its relationship to dental caries.


Primary afferent depolarization: direct evidence in the trigeminal system.


Mineral composition of normal human enamel and dentin and the relation of composition to dental caries. I. Macrominerals and comparison of methods of analyses.


Causes of blindness in the world. Communication at the Budapest Congress.


Field desorption mass spectra of antibiotics.


Observations on the sporogonic cycle of Plasmodium berghei in two Australasian anophelines.


Secretor status and dental caries.

Secretor status and dental caries.


An epidemic of chikungunya fever at Ibadan, Nigeria, 1969.


Inheritance of susceptibility to Dirofilaria immitis infection in Aedes aegypti.


Vascularization of porcine skin heterografts.


Some new concepts in immunological phylogeny.


Dissociation between effects of nerve growth factor on tyrosine hydrolase and tubulin synthesis in sympathetic ganglia.


Heme-spin label studies of hemoglobin. II. Spin-labeled oxy- and deoxyhemoglobins.


Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritance of tyrosine hydroxylase, dopamine-beta-hydroxylase, and phenylethanolamine N-methyltransferase.


Superoxide dismutase in the anaerobic flagellates, Tritrichomonas foetus and Monocercomonas sp.


Cardiovascular actions of a new metabolite of propranolol: isopropylamine.


Studies on the effects of enantiomers of soterenol, trimetoquinol and salbutamol on beta adrenergic receptors of isolated guinea-pig atria and trachea.


Absence of degeneration of adrenergic neurons after prolonged treatment with debrisoquin.


A role for nicotinic receptors in the regulation of the adenylate cyclase of adrenal medulla.


A comparison of the effects of amphetamine and its metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine, on uptake, release and catabolism of 3H-norepinephrine in cerebral cortex of rat brain.


Metabolic inhibitors and viral lymphomagenesis in thymic grafts.


Biochemical properties of neoplastic cell mitochondria.


In vitro effects of iodinated arthrographic contrast media on bacterial growth.


Letter: Trojan Horse lymphocytes.

Letter: Trojan Horse lymphocytes.


Normal histocompatibility antigens as a model for tumors.


The undifferentiated and extended forms of C1300 murine neuroblastoma. An ultrastructural study and detection of concanavalin A binding sites on the plasma membrane. Mouse neuroblastoma cells (clone neuro-2A) in the undifferentiated and "differentiated" form were compared by light and electron microscopy. "Cytodifferentiation" was induced in monolayer cultures by the addition of dibutyryl-cyclic AMP. The pattern of concanavalin A binding sites was studied after coupling with horseradish peroxidase. The following major differences were observed. The differentiated cells are characterized by numerous and long neurites, aggregation of ribosomes into polysomes, an extensive network of neurofilaments and microtubules, many dense-core neurosecretory-like vesicles, a discontinuous pattern of concanavalin A binding sites on the plasma membrane, and an increase of the specific activities of acetylcholinesterase, choline acetylase and tyrosine hydroxylase. In contrast, the undifferentiated cells grown in suspension culture lack neurites, contain dispersed ribosomes, infrequent neurofilaments and microtubules and dense-core neurosecretory-like vesicles, and exhibit a continuous pattern of concanavalin A binding sites. In addition, the specific activities of the above mentioned enzymes are significantly lower.


The complement system in necrotizing angiitis of the skin. Analysis of complement component activities in serum of patients with concomitant collagen-vascular diseases.


A comparison of enzyme-active membrane antigens from two different 4-dimethylaminoazobenzene-induced rat hepatomas with those of adult and fetal rat liver.


The natural (and unnatural) history of hypertrophic obstructive cardiomyopathy.


Alpha-beta-adrenergic imbalance in intrinsic-intolerance rhinitis or asthma.


Parenterally transmitted hepatitis A associated with platelet transfusions. Epidemiologic study of an outbreak in a marrow transplantation center.


Letter: Beta-blockade in the presence of renal disease and hypertension.


The effect of antilymphocytic antibody on the humoral immune response of different strains of mice. IV. Variable effect of individual ALG preparations on the immune response to type 3 polysaccharide antigen.


An analysis of affinity chromatography using immobilised alkyl nucleotides.


Sero-survey of Salmonella infection in man and animals by indirect haemagglutination test.


Excretion of orally administered intestinal bacteria in humans.


Effect of variation in growth temperature on the biochemical activity and antigens of Mycobacterium marinum.


Release of dipicolinic acid (DPA) from spores of Bacillus megaterium, B. stearothermophilus and B. anthracis in presence of bile acids.


Effect of early transplant function as an index of recipient presensitization on long-term function of machine-preserved cadaveric kidneys.


Cryocurettage in the treatment of corneal ulcers: additional observations.


Proceedings: Effect of histamine H2-receptor antagonists on gastric secretion, circulation, and acid-base-balance in cats.


Proceedings: Effect of insulin on pyridinenucleotides in pancreatic islets.


Proceedings: The influence of steroids on microsomal NADH oxidation in rat liver and human placenta.


Proceedings: A simple screening method for the evaluation of beta-sympatholytics.


Proceedings: Kinetics of distribution and elimination of a basic lipophilic drug metabolite in the rat.


Proceedings: Influence of epoxide hydrase inhibitors on mutagenic effects of reactive metabolites generated in situ from benzo(a)pyrene.


Proceedings: Non-specific cardiodepressant effects and hydrophobicity of two series of beta-adrenergic blocking drugs: influence of ring-alkylation and of n-alkylation.


Proceedings: Glucose release of the rat kidney in vivo after beta-adrenergic stimulation and blockade.


Proceedings: Evidence for oxidative metabolism of metyrapone in rat liver microsomes.


Proceedings: Cyclic GMP formation in human platelets.


Proceedings: Combined effects of Lb46 resp. practolol and histamine on parameters of respiration and circulation in guinea pigs.


Proceedings: Uptake of neurotransmitters into subcellular particles of the caudate nucleus.


Proceedings: Effect of serotonin on water intake and renin-angiotensin system in rats.


Proceedings: Localization of alpha-adrenoceptors in the CNS with facilitatory effect upon vagal reflex cardioinhibition.


Proceedings: Clinical investigations on the chronic intoxication with bromocarbamides (carbromal and bromisoval).


Proceedings: Influence of different metabolic conditions on the affinity of alpha- and beta-sympathomimetic drugs on the rabbit aortic strip.


Proceedings: Comparison of the inducing effect of halothane and ethrane in rat liver.


Proceedings: Changes of the oxygen consumption in the heart muscle cell related to the heart rate and contraction force.


Proceedings: Relationship between activity and structure in derivative of clonidine.


Pathways of assimilation of dissolved organic matter by plankton organisms.


The role of gamma-aminobutyric acid as a mediator of positive dorsal root potentials.


One thousand laparoscopies at a community hospital.


On the nature of the adrenergic neuron extragranular amine binding site.


A comparison of the properties of membranes isolated from bovine skim milk and cream.


Malonate metabolism in rat brain mitochondria.


Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.


A discussion on human adaptability in a tropical ecosystem an IPB human biological investigation of two New Guinea communities. Geographical, historical and social background of the peoples studied in the IBP.


The demography of the population of Karkar Island.


Movement, relatedness and the genetic structure of the population of Karkar Island.


The hereditary blood factors of the peoples of New Guinea and the surrounding regions.


Genetic distances between certain New Guinea population studied under the International Biological Programme.


The occurrence of haemoglobin-J (Tongariki) and of thalassaemia on Karkar Island and the Papua New Guinea mainland.


An anthropometric survey of growth and physique of the populations of Karkar Island and Lufa subdistrict, New Guinea.


Karkar and Lufa: an epidemiological and health background to the human adaptability studies of the International Biological Programme.


The energy and nutrient intake and the energy expenditure of 204 New Guinean adults.


Lung function and the response to exercise in the New Guineans: role of genetic and environmental factors.


Anthropometric and other factors affecting respiratory responses to carbon dioxide in New Guineans.


A study of temperature regulation in New Guinea people.


Why develop a conceptual framework?

Why develop a conceptual framework?


A practical evaluation of nursing care as part of the nursing process.


A field survey of thermal stress in New Guinea villagers.


Foundations of education for students and teachers of nursing.


Organization of a family experience.

Organization of a family experience.


The clinical instructor as role model.

The clinical instructor as role model.


The book review: a significant educational resource.


Nucleotides and nucleic acids.

Nucleotides and nucleic acids.


Investigation of H-2 and non-H-2 antigens on the mouse blastocyst.