A new, simple method for the preparation of lymphocytes bearing specific receptors.


A perspective on antitrypsin deficiency.


A public speaking course for foreign medical graduates.


A rabbit with the allotypic phenotype: ala2a3 b4b5b6.


A simple and reproducible method of isolating rat peritoneal mast cells in high yield and purity.


A simple method for the preparation of pure and active gamma-globulin-ferritin conjugates using glutaraldehyde.


A study of questions connected with the production of immunoglobulin preparations labelled with fluorescein isothiocyanate.


A supravital stain for nucleoli in human lymphocytes.


A theory of lymphocyte blast transformation (LBT) and malignant change based on proteolytic cleavage of trigger peptide: the detendomer.


A unified theory of the control of actin and myosin in nonmuscle movements.


Abnormality in normal development. A concept of symptom formation in childhood.


Acid-base diagrams maths, myths, and measurements.


Actinomycin binding and uridine incorporation by human normal bone marrow cells.


Active-passive immunization of human subjects against tetanus using homologous gamma globulin.


Adenoid cystic carcinoma of the prostate. Report of a case.


Acute effects of gonadotrophins and prostaglandins on the metabolism of isolated ovarian follicles from PMSG-treated immature rats.


Age and organ dependent variations in the number of thymus derived RTLA bearing cells.


Alizarin red. Vital staining of cornea and conjunctiva.


Alpha chain determinants on the membrane of immunoglobulin synthesizing cells.


Alpha Fetoprotein: An index of progression or regression of hepatoma, and a target for immunotherapy. CLINICAL AND LABORATORY STUDIES OF AFP PRODUCING HEPATOMAS DEMONSTRATED THAT: 1) serum AFP levels correlated directly with tumor growth; 2) circulating AFP could be cleared by passive administration of an. excess of anti-AFP; and 3) highly specific anti-AFP functioned as a carrier to localize diagnostic and possibly therapeutic amounts of radioactivity in hepatoma tissue. These studies helped elucidate certain criteria which should be fulfilled before attempts to initiate passive humoral immunotherapy of cancer are undertaken.


Ampicillin nephropathy.

Ampicillin nephropathy.


An attempt to correlate RNA-templated DNA polymerase activity with virus-like particles in human milk: murine mammary tumor virus (MuMTV) as a model system.


An audio-visual teaching programme for training home dialysis patients.


An epidemic of canine scabies in man.

An epidemic of canine scabies in man.


Air pollution and the eye.

Air pollution and the eye.


An introduction to dentistry for the blind.


Andrew Wilson.

Andrew Wilson.


Antegrade concealed conduction to the His bundle; documentation with His bundle recording.


An electron microscopic study of the tympanojugular glomus.


Anti-immunoglobulin antibodies in immunodeficiencies: their influence on intolerance reactions to gamma-globulin administration.


Antibody affinity. VII. Multivalent interaction of anti-lactoside antibody.


An informatic analysis of serum protein disturbances in clinical pathology.


Antidepressant action of tryptophan.

Antidepressant action of tryptophan.


An immunological study of subacute sclerosing panencephalitis: measles and tissue antigens and immunoglobulins.


Antigenic properties of a non-collagenous reticulin component of normal connective tissue.


Apparent violation of "Landsteiner's law".


Association constant and heterogeneity index of antibodies specific for a natural determinant of a bacterial protein. Time-course studies during the in vitro immune response to a distinct site of Escherichia coli beta-D-galactosidase.


Association of S-IgA subunits.

Association of S-IgA subunits.


Atherosclerosis in aortocoronary vein grafts.


Are gastrin-cells present in mammalian pancreatic islets?


Atypical azurophilic crystals in chronic lymphocytic leukemia. A case report and comparison with other crystalline inclusions.


Australia antigen (HB-Ag) subtyping by a sensitive tanned cell haemagglutination-inhibition technique.


Autoradiographic studies of migrating neurons and astrocytes of human fetal cerebral cortex in vitro.


Balloon atrioseptostomy. A palliative measure for transposition of the great arteries and certain other critical congenital cardiac defects.


Binding of antinucleoside antibody to DNA.


Antitumor antibiotics.

Antitumor antibiotics.


Binding of secretory piece to polymeric IgA and IgM paraproteins in vitro.


Biochemical properties of reverse transcriptase activities from human cells and RNA tumor viruses.


Biondi-like cell inclusions in the human iris.


Biosynthesis and metabolism of collagen and its role in tissue repair processes.


Biosynthesis of hypothalamic hypophysiotropic factors.


Blood group investigations among the gypsy population of Hungary. II. Examinations of haptoglobin types and level and GM(1) factor.


Blood group specificity of the lectin from Lotus tetragonolobus.


Bulk flow of interstitial fluid after intracranial injection of blue dextran 2000.


Carcinoma of the pancreas. A program for increasing survival.


Cell mediated lympholysis in man. Occurrence of unexpected, HL-A (LA and FOUR) irrelevant lympholysis.


Cell types contributing to the biosynthesis of sIgA.


Cells involved in the immune response. XXVI. The demonstration of bone marrow-specific antigens in the rabbit.


Cells involved in the immune response. XXVII. The demonstration of appendix-specific antigens in the rabbit.


Centric fusion, satellite DNA, and DNA polarity in mouse chromosomes. A fluorescent staining technique has demonstrated a contralateral arrangement of fluorescent spots in the centromeric region of mouse metacentric chromosomes which have resulted from centric fusion. The results suggest that centric fusion involves the maintenance of DNA polaritv through the centromere and that the thymidine-rich chain of satellite DNA in the centromeric region is associated with the same DNA chain in every mouse autosome.


Characteristics of SC-Ig complexes formed in vitro.


Changes of the luminal surface of the rat uterus at blastocyst implantation. Scanning electron microscopy and ruthenium red staining.


Characterization of the surface protein components in adipocyte plasma membranes.


Christchurch Clinical School audio visual services for lecture theatres and other teaching areas.


Chemoimmunotherapy of cancer. 1.

Chemoimmunotherapy of cancer. 1.


Chromosomes of the African ground squirrel, Xerus rutilus (Rodentia: Sciuridae).


Cellular immunity in systemic lupus erythematosus.


Chronic experimental allergic encephalomyelitis in inbred guinea pigs. An ultrastructural study.


Clonal depletion in neonatal tolerance.

Clonal depletion in neonatal tolerance. Specific unresponsiveness can be induced in neonatal and adult BALB/c mice by antibody against antigen-specific receptor (antireceptor antibody). When heterologous antireceptor antibody is used in the indirect fluorescence technique, the number of fluorescent cells in these animals is significantly lower than in normal animals. Fluorescent cells appear after a relatively brief incubation of cells from adult-suppressed animals, whereas no fluorescent cells are detected when cells from neonatally treated animals are incubated briefly. Evidently, treating neonatal mice with antireceptor antibody specifically depletes the antigen-responsive clone. In contrast, antireceptor antibody causes reversible blockade of responsive cells in adult-suppressed animals.


Common misconceptions about the prostate gland.


Community agency includes role-PLAYING, DEMONSTRATIONS IN CAREER-DAY PROGRAMS.


Common antigenic structures of HL-A antigens. 3. An HL-A common antigenic marker closely associated with HL-A alloantigenic activity and detected by use of rabbit anti-rhesus monkey cell membrane antibodies.


Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies. A new idiotypic determinant(s) on mouse anti-PC antibodies is described. Antibodies to the determinant(s) were raised in rabbits by immunization with HOPC 8, a PC-binding myeloma protein, and were isolated from HOPC 8 immunoadsorbent by elution with PC. These antibodies react with binding site determinants on anti-PC antibodies raised in all 15 inbred mouse strains tested regardless of histocompatibility or allotype, but fail to react with antibodies of other specificities or with anti-PC antibodies raised in other rodent species. These results correlate closely with other studies which show similar binding specificity of anti-PC antibodies raised in 17 different strains of mice. The site-associated idiotypic determinant(s) is clearly distinct from that detected by mouse anti-HOPC 8 antisera. This latter determinant(s) is present on anti-PC antibodies of only a few strains of mice and may not be in the binding site.


Comparative biochemical properties of RNA-directed DNA polymerases from Rauscher murine leukemia virus and avian myeloblastosis virus.


Comparative chromosome studies in Cetacea.


Comparison of ventricular parasystole with other dysrhythmias after acute myocardial infarction.


Complex formation of guinea-pig liver diamine oxidase (histaminase) with heparinoids.


Circadian rhythm of cell proliferation in rat liver: synchronization by feeding habits.


Circulating anticoagulant in disseminated lupus erythematosus. Proposed mode of action.


Control of spillover. The importance of Kupffer-cell function in clinical medicine.


Control of respirator-associated infection due to Pseudomonas aeruginosa.


Controlled trial of co-trimoxazole in children with urinary-tract infection. Bacteriological efficacy and haematological toxicity.


Contrast media as histamine liberators in man.


Corneal collagenase: specific cleavage of types (alpha 1)2 alpha 2 and (alpha 1)3 collagens.


Correction of neutropenia associated with dysgammaglobulinemia.


Correlation between the synthetic activity and classification of reticulocytes.


Cytology of leukocyte concentrates.

Cytology of leukocyte concentrates.


Coumarin anticoagulants: a review of some current research areas.


Cytotoxicity of three endodontic intracanal medicaments.


Comparisons of glaucomatous visual fields using the black tangent screen and the Goldmann perimeter.


Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses.


Decreased globin messenger RNA in thalassemia by hydridization and biologic activity assays.


Degeneration argyrophilia as an index of neural maturation: studies on the optic tract of the golden hamster.


Delayed recovery of intellectual function after minor head injury.


Delta5-3beta-hydroxysteroid dehydrogenase and estradiol-17beta-hydroxysteroid dehydrogenase activity in preimplantation hamster embryos.


Desensitization of rat mast cells by the use of theophyllin.


Desensitization in the process of histamine secretion induced by antigen and dextran. 1. Antigen challenge of sensitized rat peritoneal mast cells in the absence of calcium failed to release histamine. The release when calcium was added subsequently declined rapidly, this desensitization being almost complete in 4 min.2. Phosphatidyl serine (10 mug/ml.) reduced the rate of desensitization so that decay of the response to added calcium was not complete after 16 min.3. Exposing normal cells to dextran resulted in a slow rate of desensitization, the response to phosphatidyl serine added with calcium having decayed by only 27% within 10 min.4. Phosphatidyl serine added with dextran prevented desensitization so that the response to subsequently added calcium did not decay even after an interval of 20 min.5. Cells activated by dextran and calcium became rapidly desensitized as shown by decay of the response to added phosphatidyl serine which was almost complete by 5 min.6. Histamine release by the calcium ionophore (A 23187) added to cells at intervals before the addition of calcium did not show significant decay.7. Desensitization of the cells to antigen did not change their response to the ionophore.


Determination of the noraml values of some human plasma proteins by means of quantitative radial immunodiffusion.


Detection of type C viruses in normal and transformed cells.


Diagnosis of regional lymph node metastases in cancer of the breast. A study of the lymphatic system of the diseased breast.


Differential staining of human and mouse chromosomes in interspecific cell hybrids.


Diagnostic value of the PAS-positive lymphocyte index in diabetes.


Diversity of antibodies to cross-reacting nitrophenyl haptens in inbred mice.


DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile.


Drug spotlight program: systemic corticosteroid therapy: pharmacology and endocrinologic considerations.


Early psychosomatic symptom and the tendency towards integration.


Editorial: "A-huffin' and a-puffin', a-sniffin' and a-suckin.'".


Editorial: Accreditation of psychiatric facilities serving children and adolescents.


Editorial: Asynergy and ventricular premature beats.


Editorial: Computers or nurses?

Editorial: Computers or nurses?


Distribution of heterochromatin in type-3 Y and other chromosomes of Drosophila athabasca.


Editorial: Delaying premature labour.

Editorial: Delaying premature labour.


Editorial: Does this chemical cause cancer in man?


Editorial: Endemic goitre on Idjwi island.


Editorial: Immunology and developing countries.


Editorial: Neuralgic amyotrophy.

Editorial: Neuralgic amyotrophy.


Editorial: Occupational leucoderma.

Editorial: Occupational leucoderma.


Editorial: Rodent control and lassa fever.


Editorial: Oestradiol receptors in human breast cancer.


Editorial: Something rotten in Scotland, and elsewhere.


Editorial: Testing renal function.

Editorial: Testing renal function.


Editorial: Where the axe is falling.

Editorial: Where the axe is falling.


Education of medical students in general pathology. Comparison of learning strategies: lecture, audiovisomat, self instruction.


Effect of ethanol on the hypertonic saline-induced histological changes in the hypothalamic neurosecretory system of the spotted owlet, Athene brama Temminck.


Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve.


Effect of histamine releasing agents on the metabolism of exogenous glucose in rat mast cells.


Effect of ribonuclease treatment on nuclear, dRNA-containing 30 S ribonucleoprotein particles.


Effects of carbon monoxide on coronary heart disease.


Effects of chlordiazepoxide in respiratory failure due to chronic bronchitis.


Effects of sodium fluoride and other metabolic inhibitors on basal and TSH-stimulated cyclic AMP and thyroid metabolism.


Effects of splenectomy on amphibian antibody responses.


Elastic tissues in adenoid cyctic carcinomas.


Electrical measurement of intestinal absorption of glucose in man.


Elevations in serum glycoprotein-N-acetylneuraminic acid transferases in rats bearing mammary tumors.


Elevated plasma histamine concentrations in surgery: causes and clinical significance.


Endogenous RNA-directed DNA polymerase activity in normal cells.


Enzyme histochemical investigations of heterotopic gastric epithelium in the duodenum.


Erythropoietin-stimulated proliferation of human red cell precursors in vitro.


Ethical dilemmas in the care of the critically ill.


Effects of stay at high altitude on the serum proteins of man.


Evaluation of the nitroblue tetrazolium test as applied to polymorphonuclear leukocytes in the cerebrospinal fluid.


Electron microscope study of Erythema nodosum leprosum.


Evidence for a common synthetic origin for secretory and serum IgA.


Evidence for two linked loci controlling ther serologically defined leukocyte antigens of chimpanzees (ChL-A).


Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex. Immunoglobulin complexes, composed of heat-aggregated human Ig, were shown to bind to mouse B lymphocytes of a variety of strains, but not to either thymocytes or thymus-derived (T) lymphocytes under a variety of conditions. It was shown that this binding was not due to either natural human antibodies against mouse nor to nonspecific binding of human Ig by mouse lymphocytes. Such complexes were shown to bind to the same sites which bind mouse antibody-antigen complexes. This site is known as the Fc receptor. The binding of Ig complexes to mouse B lymphocytes was markedly inhibited by pretreatment of the lymphocytes with anti-H-2 antisera. A series of experiments indicated the specificity of this result, including the fact that this inhibition was shown not to be due to the artifact of shedding of H-2 antibody-antigen complexes, nor to nonspecific steric inhibition. The antibodies within anti-H-2 antisera which were responsible for this inhibition were specific for alloantigens associated with the Ir region of the H-2 complex (Ia antigens). Antiserum specific for these Ia antigens produced inhibition, whereas antisera specific for antigens determined by the K or D regions of the H-2 complex did not. Evidence was obtained using F(1) hybrid cells that at least some Ia antigens of both parental types are expressed on every B lymphocyte (i.e. codominant expression). These data indicate that the Fc receptor and a series of alloantigens controlled by the Ir region of the H-2 complex are identical or closely associated on the B-lymphocyte surface membrane. This observation may have implications for the mechanism of control of the immune response.


Evidence of particle-associated RNA-directed DNA polymerase and high molecular weight RNA in human gastrointestinal and lung malignancies. Previous communications have demonstrated that neoplastic cells of human breast cancers, leukemias, lymphomas, sarcomas, and brain tumors contain particles with similar diagnostic attributes as those found in RNA oncornaviruses. The present paper concerns malignancies of the gastrointestinal and pulmonary systems for which, like brain tumors, no suitable animal model or corresponding virus exists. By means of the simultaneous detection assay, these tumors have been found to contain 70S RNA and RNA-directed DNA polymerase encapsulated in particulate components possessing densities of 1.16-1.17 g/ml. Twelve out of 17 (70%) colon carcinomas, three out of five (60%) gastric carcinomas, all of three rectal carcinomas, and seven out of ten (70%) lung carcinomas contained detectable levels of these virus-like entities. None of the corresponding normal tissues was positive.


Experimental' pregnancy: the ethical complexities of experimentation with oral contraceptives.


Experimental chemotherapy in carcinoma of the cervix.


Factors limiting the histochemical reaction of choline dehydrogenase activity.


Evidence that different antibodies are involved in the production of immunologically induced teratogenesis and nephritis.


Failure of bleomycin to affect humoral or cell-mediated immunity in the mouse.


Familial clustering of hepatitis B antigen: a study in relatives of patients with liver diseases and hepatitis B antigenaemia. Twelve of the 100 family contacts of 29 patients with transient and persistent hepatitis B antigenaemia were found to be positive for hepatitis B antigen (HBAg). No relation was found between familial clustering and the nature of liver disease or the duration of antigenaemia in the index cases.Eight affected relatives were apparently healthy carriers of HBAG, one had cirrhosis, and three (in the same family) developed acute viral hepatitis.The absence of parenteral exposure in the HBA,-positive family contacts and the identity in antigenic determinants d or y with those of the index cases, suggest a non-parenteral spread of HBAg in families of patients with HBAg-associated liver diseases.


Familial Hodgkin's disease: an environmental and genetic disorder.


Fiber types in human masticatory muscles. Relation to function.


Fibrinoid necrosis in granuloma induced by imcomplete Freund adjuvant.


Fibrinolytic split products (FSP) and ethanol gelation test in preoperative evaluation of patients with prostatic disease.


Fibre composition, enzyme activity and concentrations of metabolites and electrolytes in muscles of standardbred horses.


Fine structure of the synaptic endings on the Mauthner cell of the goldfish.


Fine structural, HaLV gs antigen, and reverse transcriptase study of the Syrian hamster stilbestrol-induced renal carcinoma.


Fingerprinting techniques as aids in the analysis of composite chemical pollutants in the environment.


Five-year ballistocardiographic follow-up of a patient with an implanted starr valve in mitral position.


Focal aortic injury caused by cannulation: increased plasma protein accumulation and thrombosis.


Formaldehyde condensation at reduced temperature. Increased sensitivity and specificity of the fluorescence microscopic method for demonstrating primary catecholamines.


Follow-up of patients with pulmonary tuberculosis adequately treated by chemotherapy: is this really necessary?


Functional characterization of membrane components of cytotoxic peritoneal exudate T lymphocytes. I. Search for T cell receptor activity in lymphocyte membrane fractions.


Fluorescent staining for Mycobacterium leprae in tissue sections. Comparison with Fite-Faraco procedure.


Furcation canals in the human mandibular first molar.


Further observations on a human syncytial virus from a nasopharyngeal carcinoma.


G-G translocation and chronic myelocytic leukaemia.


Galvanic separation of X- and Y-bearing human spermatozoa.


Gamma-heavy chain disease. Preliminary studies in three cases.


Gastric endocrine cell proliferation. Association with Zollinger-Ellison syndrome.


Genetic control of immune responses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by the terpolymer L-glutamic acid 60-L-alanine 30-L-tyrosine 10 (GAT). In recent studies we have found that GAT not only fails to elicit a GAT-specific response in nonresponder mice but also specifically decreases the ability of nonresponder mice to develop a GAT-specific PFC response to a subsequent challenge with GAT bound to the immunogenic carrier, MBSA. Studies presented in this paper demonstrate that B cells from nonresponder, DBA/1 mice rendered unresponsive by GAT in vivo can respond in vitro to GAT-MBSA if exogenous, carrier-primed T cells are added to the cultures. The unresponsiveness was shown to be the result of impaired carrier-specific helper T-cell function in the spleen cells of GAT-primed mice. Spleen cells from GAT-primed mice specifically suppressed the GAT-specific PFC response of spleen cells from normal DBA/1 mice incubated with GAT-MBSA. This suppression was prevented by pretreatment of GAT-primed spleen cells with anti-theta serum plus C or X irradiation. Identification of the suppressor cells as T cells was confirmed by the demonstration that suppressor cells were confined to the fraction of the column-purified lymphocytes which contained theta-positive cells and a few non-Ig-bearing cells. The significance of these data to our understanding of Ir-gene regulation of the immune response is discussed.


Genetically-associated variations in the distribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampus.


Genetics and evolution of human immunoglobulin A.


Glucagon-mediated changes in the concentration of rat hepatic tyrosine transaminase: an immunochemical analysis.


Glucocorticoid inhibition of antigen-evoked histamine release from human skin.


Glutaraldehyde fixed-antigen sensitized stable cells in indirect hemagglutination test for rapid diagnosis of hydatid disease, trichinosis and amoebiasis.


Graves disease and idiopathic thrombocytopenic purpura.


Handwashing: surgical wards. Soap and water compared with 70% alcohol.


Gut-associated lymphoblasts and intestinal IgA plasma cells.


Hapten-carrier relationships in immunological unresponsiveness. II. Decrease of antibody affinity and specificity in B cell tolerance.


Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells.


Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes.


Hepatitis A and B.

Hepatitis A and B.


Hearing loss in paranoid and affective psychoses of the elderly.


Hepatitis B transmitted by a human bite.


Herpesvirus hominis: from latency to carcinogenesis?


Heterologous recombination between mouse myeloma 315 heavy chains and rabbit antibody light chains: structural and functional properties of the hybrid molecules.


HeLa cell R-deoxyribonucleic acid polymerases. Separation and characterization of two enzymatic activities.


High-speed liquid chromatographic cleanup of environmental samples prior to the gas chromatographic determination of lindane.


Histochemical and electron microscopic studies on argyrophil granules in eccrine sweat gland cells in the pigmented skin of Riehl's melanosis. I. Histochemical studies.


Histamine release by dextrans from rat peritoneal cells.


Histochemical and electron microscopic studies on argyrophil granules in eccrine sweat gland cells in the pigmented skin of Riehl's melanosis. II. Electronmicroscopic studies.


Histochemical enzyme profile of the masseter muscle in different mammalian species.


Histological, histochemical and ultrastructural studies on the nature of hyalin bodies in odontogenic cysts.


Horseradish peroxidase histochemistry: a new method for tracing efferent projections in the central nervous system.


Human leukocyte locus A (HL-A) antigens and infectious mononucleosis.


Human secretory component. NH2-terminal amino acid sequences and peptide maps of the form occurring in exocrine immunoglobulin A and the free form.


Humoral and cell-mediated immune responses of Lewis rats to syngeneic basic protein of myelin.


HL-A antibodies and cold lymphocytotoxins.


HL-A antigens and diabetes mellitus.

HL-A antigens and diabetes mellitus.


HL-A histocompatibility antigens and skin diseases.


HL-A in psoriasis vulgaris and in pustular psoriasis--population and family studies.


Imagery techniques in psychiatry.

Imagery techniques in psychiatry.


Identification of human and mouse chromosomes in human-mouse hybrids by centromere fluorescence.


Immunogenicity of lowly and highly derivatized dinitrophenyl-bovine gamma-globulin in different strains of guinea pigs.


Immunoenzymology of Clostridium histolyticum collagenase.


Immunoglobulins, basic myelin proteins and age in man and monkeys.


Immunohistochemistry of liver in alpha1-antitrypsin deficiency. A comparative study.


Immunological studies in nephropathies accompanying childhood diabetes mellitus.


Improved plasma culture system for production of erythrocytic colonies in vitro: quantitative assay method for CFU-E.


In vitro hyposensitization of rat mast cells by antigen.


In vivo kinetic studies in human myeloma.


Inborn errors of morphogenesis. A review of localized hereditary malformations.


Induction of endoreduplication in cultured mammalian cells by some chemical mutagens.


Infectious DNA intermediate of an oncogenic RNA virus.


Influence of orally administered antibiotics on anti-T agglutinin of normal subjects and of cirrhotic patients.


Inhibition of the growth of tumour cells in culture by noxytiolin.


Inhibition by nicotinamide of a homologous PCA reaction and antigen-induced histamine release from isolated rat peritoneal mast cells.


Initiation of antibody responses by different classes of lymphocytes. IV. Lymphocytes involved in the primary antibody response to a hapten-protein conjugate.


Isoelectric focusing in gels.

Isoelectric focusing in gels.


Intracellular localization of basement membrane antigen in parietal yolk sac cells. Basement membrane antigen was localized in murine parietal yolk sac cells using the peroxidase-labeled antibody technic. In these cells the antigen can be localized in the rough endoplasmic reticulum and perinuclear space. In spite of the proven ability of the antibody to permeate all cell compartments, the antigen was never localized within elements of the Golgi complex. These findings suggest that the rough endoplasmic reticulum of the parietal yolk sac cells is responsible for the synthesis of the antigenic portion of the basement membrane molecule. At the present time there is no evidence implicating the Golgi complex in the synthesis or intracellular transport of the antigenic portion of basement membrane.


Isolation and characterization of catalase produced by Mycobacterium tuberculosis.


Isolation and localization of an iron-binding rabbit seminal plasma antigen.


Isolation of mast cell degranulators from the celomatic fluid of Parascaris equorum.


Isolation of recombinant IgG molecules carrying heavy chain allotypes transmitted in repulsion.


Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus.


Isolation of microsomal poly(A)-RNA from rat brain directing the synthesis of the myelin encephalitogenic protein in Xenopus oocytes.


Kinetocardiographic findings in ventricular premature beats. An atraumatic approach to the problem of cardiac dyssynergy.


Later responses of alcoholics to crisis.


L-cystinyl-di-beta-naphthylamide hydrolase ("oxytocinase") in human colostrum and early milk plasma. Separation of two isozymes by acrylamide gel electrophoresis.


Lateral asymmetry in the fluorescence of human Y chromosomes stained with 33 258 Hoechst.


Letter: Acneiform lesions in combined rifampicin treatment in Africans.


Lectin and agglutinin receptors of red cell components.


Letter: Activity of silver sulphadiazine against dermatophytes.


Letter: Aetiology of kwashiorkor.

Letter: Aetiology of kwashiorkor.


Letter: Alpha-fetoprotein in amniotic fluid in early normal pregnancy and intrauterine fetal death.


Interferon effect on cellular functions: enhancement of virus induced inhibition of host cell protein synthesis in interferon-treated cells.


Letter: Anencephalus and legitimacy.

Letter: Anencephalus and legitimacy.


Letter: Antenatal diagnosis of genetic disease.


Letter: Antibiotic-bone-cement mixtures in prevention of infection following total joint replacement.


Letter: Assay of gentamicin.

Letter: Assay of gentamicin.


Letter: Biochemical lesion in vitamin-B12 deficiency in man.


Letter: B-lymphocyte nature of hairy cells in hairy-cell leukaemia.


Letter: Blood-lead levels, behaviour, and intelligence.


Letter: Catalin, quinones, and cataract.


Letter: Cervical cancer and sexual behaviour.


Letter: Classification of non-Hodgkin's lymphomas.


Letter: Cleavage of heme from horseradish peroxidase by methanol with inhibition of enzymic activity.


Letter: Complex and polyfunctional antibodies.


Letter: Continuous blood-sampling.

Letter: Continuous blood-sampling.


Letter: Corticosteroids in Landry-Guillain-Barré-Strohl syndrome.


Letter: Cyclophosphamide and neoplasia.

Letter: Cyclophosphamide and neoplasia.


Letter: Diagnosis and treatment of hypertension.


Letter: Differentiation between neonatal hepatitis and biliary atresia by measuring serum-alpha-fetoprotein.


Letter: Drug induced aplastic anaemia.

Letter: Drug induced aplastic anaemia.


Letter: Endoscopy in acute gastrointestinal haemorrhage.


Letter: Epilepsy in children.

Letter: Epilepsy in children.


Letter: Evaluation of laboratory tests.

Letter: Evaluation of laboratory tests.


Letter: Fasting blood-glucose levels.

Letter: Fasting blood-glucose levels.


Letter: Fever in thalassaemia.

Letter: Fever in thalassaemia.


Letter: Follow-up study of serum-creatine-kinase in carriers of Duchenne muscular dystrophy.


Letter: Free fatty acids and acute myocardial infarction.


Letter: Haemophilia carriers.

Letter: Haemophilia carriers.


Letter: Hazards of vinyl chloride.

Letter: Hazards of vinyl chloride.


Letter: Head injury and defibrination.

Letter: Head injury and defibrination.


Letter: Health services in Chile.

Letter: Health services in Chile.


Letter: Heparin thrombin clotting-time and platelet factor 4.


Letter: Heparin-induced lipolysis in the elderly.


Letter: Heterologous stimulation of hepatitis-B antigen.


Letter: Hyposplenism in ulcerative colitis.


Letter: Iron poisoning: another energy crisis.


Letter: Large intestinal-biopsy capsules and small babies.


Letter: Medicine and public health in the tropics.


Letter: Leigh's disease and failure of automatic respiration.


Letter: Lymphocyte transformation and oral contraceptives.


Letter: Migraine and diet.

Letter: Migraine and diet.


Letter: Multiple sclerosis: a fever blister on the brain?


Letter: Meeting the need for doctors.

Letter: Meeting the need for doctors.


Letter: Need for medical superintendents.


Letter: Oral contraceptives, allergy, pregnancy, and depression.


Letter: Oral hypoglycaemic therapy in diabetic pregnancies.


Letter: Osmotic error in measurements of red-cell volume.


Letter: Orbiviruses and gastroenteritis.


Letter: Pairing of X and Y chromosomes.

Letter: Pairing of X and Y chromosomes.


Letter: Predictive value of laboratory tests.


Letter: Pathogenesis of vascular proliferation in angio-immunoblastic lymphadenopathy with dysproteinaemia.


Letter: Prevention of convulsions.

Letter: Prevention of convulsions.


Letter: Prosopagnosia.

Letter: Prosopagnosia.


Letter: Quality control of gentamicin assays.


Letter: Rapid glucagon release in artificial fever.


Letter: Respiratory filters in clinical practice.


Letter: Rauwolfia derivatives and cancer.


Letter: Retinal infarction during haemodialysis.


Letter: Rifampicin and cortisone replacement therapy.


Letter: Scientific medicine.

Letter: Scientific medicine.


Letter: Self-testing reagents for diabetics.


Letter: Seasonal occurrence of ventricular septal defect.


Letter: Skin wrinkling and nerve function.


Letter: Skin wrinkling in cystic fibrosis.


Letter: Smoking and lung cancer.

Letter: Smoking and lung cancer.


Letter: Sulphasalazine-induced lung disease.


Letter: SI units.

Letter: SI units.


Letter: ST-segment displacement after acute myocardial infarction.


Letter: T lymphocytes in fulminating hepatitis.


Letter: Tests for drug allergy.

Letter: Tests for drug allergy.


Letter: Terminology in biliary radiology.


Letter: The megavitamin scene.

Letter: The megavitamin scene.


Letter: Tests of liver function.

Letter: Tests of liver function.


Letter: Transfer-factor therapy of chronic active hepatitis.


Letter: Transient hypotension after anaesthesia of peritoneum.


Letter: Treatment of excessive axillary sweating.


Letter: Tuberculin in rheumatoid arthritis.


Letter: Unexplained tetanic spasms.

Letter: Unexplained tetanic spasms.


Letter: Uptake of 35S-heparin by lymphocytes from cystic-fibrosis patients.


Letter: Uterine pulsation as sign of early pregnancy.


Letter: Vitamin A and rat embryos.

Letter: Vitamin A and rat embryos.


Letter: Von-Willebrand-factor activity in pregnancy.


Letter: What test and when?

Letter: What test and when?


Letter: Whooping-cough vaccination.

Letter: Whooping-cough vaccination.


Letter: Zinc in acrodermatis enteropathica.


Letter: 2,4-Diaminopyrimidines and heterozygous beta-thalassaemia.


Ligneous conjunctivitis.

Ligneous conjunctivitis.


Lobular carcinoma in situ of the breast with ductal involvement. Frequency and possible influence on prognosis.


Localization of the Tween 20-soluble membrane proteins of Acholeplasma laidlawii by crossed immunoelectrophoresis.


Local hemolysis plaque assay using a new method of coupling antigens on sheep erythrocytes by glutaraldehyde.


Macro- and microdifferences in blood group antigens and antibodies.


Macrophages in mouse placenta: morphologic and functional identification.


Macrophage immunity to vaccina virus: factors affecting macrophage immunity in vitro.


Mechanisms of pulmonary injury.

Mechanisms of pulmonary injury.


Methods for measurement of nitrogen oxides in automobile exhaust: a state-of-the-art report.


Migration inhibition test in leukocytes from patients allergic to penicillin.


Mitochondrial nucleoid staining with ammoniacal silver.


Mitral valve replacement and aortic valve homograft: immediate postoperative care.


Misinterpretation of cerebrospinal fluid Gram stain.


Modulation of the assembly of immunoglobulin subunits by J chain.


Morphology and cell proliferation of subepithelial fibroblasts in adult mouse jejunum. I. Structural features.


Morphology and frequency of early myocardial damage in various diseases.


Morphological types of motor nerve terminals in rat hindlimb muscles, possibly innervating different muscle fiber types.


Mortality and water-hardness in three matched communities in Los Angeles.


Motor and sensory flight neurones in a locust demonstrated using cobalt chloride.


Multiple catalases of mycobacteria: differences in molecular weight.


Mouse IgA myeloma proteins with alpha chain deletions: a comparison with human alpha chains with deletions.


Multiple precipitation in IgA radial immunodiffusion by non-identical antigens.


Murine leukemia virus group-specific antigen expression in AKR mice.


Myelin breakdown and basic protein.

Myelin breakdown and basic protein.


Myocardial damage in children and its relation to coronary artery lesions.


Myocardial sarcoidosis presenting as acute mitral insufficiency.


Neonatal tolerance induced by antibody against antigen-specific receptor. Specific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.


Needle biopsy in diffuse lung diseases.

Needle biopsy in diffuse lung diseases.


Neuronal geometry of RETZIUS cells in Hirudo medicinalis.


Nomenclature for G-bands in rat chromosomes.


Nonolfactory telencephalic afferents in the nurse shark (Ginglymostoma cirratum).


Oesophagogastrectomy in the treatment of malignancy of the thoracic oesophagus and cardia.


Oestradiol synthesis by a human breast carcinoma.


On different patterns of dendritic bundling in the cerebral cortex of the cat.


On the mechanism of histamine release from pig lung in vitro induced by extracts of cotton dust.


On the occurrence and morphology of Russell bodies in the dental granuloma. An evaluation of seventy-nine specimens.


Notes on viral oncolysis and on enhancement of tumor cell immunogenicity by adsorption of poorly infectious viruses.


One-hour radioimmunoassay of serum drug concentrations, as exemplified by digoxin and gentamicin.


Origin, distribution and differentiation of IgA-producing cells.


Palliative resection of oesophageal carcinoma without formal thoracotomy.


Parameters affecting heterogeneity of mouse anti-hapten antibody.


Ocular dominance.

Ocular dominance.


Pathology of the Eisenmenger syndrome and primary pulmonary hypertension.


Pattern formation in the imaginal discs of a temperature-sensitive cell-lethal mutant of Drosophila melanogaster.


Penetration gland secretion by hexacanths of Hymenolepis diminuta;.


Periapical inflammation in primary teeth and its effect on the permanent successors.


Phosphorylation of myelin basic protein.


Pink staining of pernicious anemia megaloblasts by alizarin red S.


Place of chemotherapy in the management of malignant diseases. A retrospective study of 86 cases.


Planning the operation of audiovisual aids in pathology. The search for optimal learning methods.


Plasma digoxin after parenteral administration. Local reaction after intramuscular injection.


Plasma fractionation in the United States. A review for clinicians.


Plasma protein pattern in acute infectious diseases.


Plasma-gastrin and acid secretion in patients with peptic ulceration.


Preoperative anaesthetic assessment clinic.


Potentiation of helper T cell function in IgE antibody responses by bacterial lipolysaccharide (LPS).


Preparation of human angiotensinogen for plasma renin concentration assay.


Preparation of iodinated tyrosine methyl ester of estradiol for radioimmunoassay.


Prescribing: a programme emphasising benefits.


Prevention and the handicapped child.

Prevention and the handicapped child.


Primary immunodeficiency.

Primary immunodeficiency.


Price of prostatectomy.

Price of prostatectomy. Three different urological units found that transurethral prostatectomy required a hospital stay at least one week shorter than open Millin or transvesical prostatectomy. By making transurethral resection more widely available there could be a substantial financial saving; but more surgeons would have to specialize in urology.


Production of an immunoglobulin-binding factor (IBF) by antigen-stimulated lymph node lymphocytes.


Propanoic acid-ferric oxide hydrosols. Differential cell surface binding and its relation to membrane lipid.


Protein and RNA synthesis in human proliferative endometrium in organ culture and the effect of progesterone.


Protein synthesis in cells of various parts of the exocrine epithelium of the rat pancreas.


Psychoanalysis, the behavioral therapies, and the world of the future.


Protonmotive force in fermenting Streptococcus lactis 7962 in relation to sugar accumulation.


Purification of influenza viruses using disulphide-linked immunosorbents derived from rabbit antibody.


Purkinje fibers of sheep papillary muscle: occurrence of discontinuous fibers.


Rapid antigenic typing of herpesvirus hominis isolates on the surface of infected cells by kinetic binding of 125I-labeled HVI antibodies.


Rapid bacteriological diagnosis of pyogenic meningitis by latex agglutination.


Quantitative histological changes in osteoarthritic hip cartilage. Morphometric analysis of 29 osteoarthritic and 26 normal human femoral heads.


Rapid microspectrofluorimetry for biochemical and metabolic studies in single living cells.


Rapid screening test for detection of elevated myo-inositol levels in human blood serum.


Reaction of cardiolipin and phosphatidylinositol antisera with phospholipid antigens.


Recurrent aphthous stomatitis and body reactivity.


Regression of stomatitis nicotina in persons with a long-standing habit of reverse smoking. Morphologic evidence of the role of ducts.


Regression of diet-induced fatty streaks in rhesus monkeys.


Relationship of carcinoembryonic antigen to blood substances A and i: evidence that the antigenic sites are on different molecules.


Retention of matrix density in adrenergic vesicles after extensive norepinephrine depletion.


Rhabdomyosarcomas induced by rous sarcoma virus in golden hamsters.


Relationship between antigen induced histamine release and cyclic AMP level in human leukocytes.


Robert John McNeill Love.

Robert John McNeill Love.


Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.


Sea-blue histiocytosis in hyperlipoproteinemia (cytomorphological, clinical and pathogenetic aspects).


RNA metabolism in the brain.

RNA metabolism in the brain.


Selective amyloid staining as a function of amyloid composition and structure. Histochemical analysis of the alkaline Congo red, standardized toluidine blue, and iodine methods.


Separation of t-RNAs by two-dimensional polyacrylamide gel electrophoresis.


Serum creatinine, urea, and protein level changes in hydatidiform mole.


Serum protein fractions as determined by cellulose actate electrophoresis in schistosoma mattheei infested sheep.


Short-term direct, and macrophage stimulated, bactericidal properties of antigen-activated lymph node cell culture fluids.


Silico-mycobacterial disease in sandblasters.


Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C. Sister chromatid exchanges in chromosomes from human lymphocytes grown two replication cycles in medium containing 5-bromodeoxyuridine can be detected by fluorescence microscopy after staining with the bisbenzimidazole dye 33258 Hoechst. These exchanges are much more frequent than chromosome or chromatid breaks and appear to be partly but not entirely due to 5-bromodeoxyuridine incorporation. Sister chromatid exchanges are extremely sensitive indicators of chromosome damage produced by DNA cross-linking agents such as mitomycin C. Significant increases in the sister chromatid exchange frequency occur with 3 ng/ml of mitomycin C; higher concentrations of mitomycin C induce further sister chromatid exchanges. Comparatively few gross chromosomal aberrations are seen in cells exhibiting as many as one hundred or more sister chromatid exchanges. Most of the damage caused by mitomycin C to chromosomal DNA is apparently repaired without detectable changes in chromosome morphology. Analysis of sister chromatid exchanges may permit more sensitive detection of damage to DNA caused by other agents than has previously been possible by classical cytological techniques.


Spasmodic torticollis: treatment by feedback display of the EMG.


Special characteristics of the IgA2 subclass.


Specific demonstration of the human hypophyseal adrenocortico-melanotropic (ACTH-MSH) cell.


Serum lipoproteins and the intravenous fat tolerance test in hypothyroid patients before and during substitution therapy.


Specific membrane properties of cat motoneurones. 1. Electrophysiological properties of cat motoneurones were measured using intracellular electrodes, after which Procion dye was injected iontophoretically into the neurone through the recording pipette.2. Histological procedures were chosen to minimize changes in neuronal morphology. Reconstructed motoneurones had more dendritic branches and larger surface areas than the Golgi-stained motoneurones of earlier reports.3. The sum of the 3/2 power of the dendritic diameters (the dendritic trunk parameter; Rall, 1959) of the reconstructed motoneurones was found to decrease with distance from the soma. Thus, the dendritic tree is not satisfactorily approximated by a non-tapering membrane cylinder.4. A computational technique was developed to allow calculation of the specific resistance (R(m)) of the membrane using the measured value of the input resistance of the motoneurone and a more detailed approximation of the dendritic tree. These calculations indicate that the average resting value of dendritic R(m) is at least 1800 Omega cm(2). The specific membrane capacity, calculated assuming uniform R(m), ranged between 2-3 muF/cm(2).


Specific positive selection of lymphocytes reactive to strong histocompatibility antigens. Selected populations of thymus-derived (T) rat lymphocytes having specific immunological reactivity to chosen histocompatibility (H) alloantigens are found among the cellular products of the mixed lymphocyte interaction (MLI). Such specific selection seems to depend on (a) the antigen-induced proliferation of specific H antigen reactive cells (HARC), and (b) the disappearance of nonreactive cells from the cultures. When the surviving cells from this lymphocyte-antigen interaction are transferred into thymectomized, X-irradiated, marrow-reconstituted syngeneic recipients (B rats) which lack detectable T-lymphocyte functions, the lymphocyte populations subsequently recovered from the hosts possess the capacity to react in the MLI and in the graft-vs.-host (GVH) reaction, and the reactions have specificity for the original priming alloantigens. In addition, these findings identify the cell that reacts in the MLI with the GVH reactive cell.


Specificity of antibodies to Streptococcus mutans; significance in inhibition of adherence.


Somatic chromosomes of the African white-tailed rat.


Specificity of cell-mediated transplantation reactions. I. Studies with the technique of inhibition of migration and an assay of tumour immunity in vivo.


Specificity of cell-mediated transplantation reactions. II. Studies with a sensitive assay of cell-mediated cytotoxicity.


Spectrophotometric determination of naphazoline and phenotolamine in some pharmaceutical preparations using sodium nitroprusside.


Specificity of the DNA product of RNA-dependent DNA polymerase in type C viruses: 3. Analysis of viruses derived from Syrian hamsters. DNA transcripts were prepared from three related viruses of hamster and analyzed by interviral hybridization and by reaction with cellular DNA. A virus (G-HaLV), isolated from a dimethylbenzanthraceneinduced tumor cell in Graffi hamsters, contained nucleic acid sequences highly specific for hamster cell DNA and did not react with mouse cell DNA nor did its transcript show homology (<5%) with mouse or rat viral RNAs. The hamster-specific sarcoma virus, B-34, isolated by Bassin and coworkers from tumors induced by the Harvey strain of murine sarcoma virus, contained mouse-, hamster-, and possibly rat-specific sequences. B-34 transcripts were predominantly mouse-specific. GLOH(-), a lymphomagenic virus derived by dilution beyond the transforming endpoint of a hamster-specific sarcoma virus obtained from tumors induced by the Gross pseudotype of murine sarcoma virus, also contained hamster- and mouse-specific sequences. Only a portion of its hamster sequence (about 50%) was shared with B-34 and G-HaLV viruses. As expected, transcripts of GLOH(-) virus were reactive with mouse and hamster cellular DNA.


Spontaneous sister chromatid exchanges detected by a BUdR-labelling method.


Sperm immunology, infertility, and fertility control.


Staged palliative resection of recurrent carcinoma of the neck using an extra anatomic carotid bypass.


Staining of histones on polyacrylamide gels with amido black and fast green.


Stimulatory immunotherapy in mammary cancer.


Structure of the O-glycosidically linked carbohydrate units of fetuin.


Studies on monoclonal antibodies. II. Immune complex (IgM-IgG) cryoglobulinemia: the mechanism of cryoprecipitation.


Studies on the action of the calcium ionophore A 23187 on isolated rat mast cells.


Studies on the biological and antigenic properties of ESP-1 type C virus particles.


Studies on the human T-lymphocyte population. I. The development and characterization of a specific anti-human T-cell antibody.


Studies on the human T-lymphocyte population. II. The use of a T-cell specific antibody in the partial isolation and characterization of the human lymphocyte receptor for sheep red blood cells.


Studies on the nature of the abnormality of B cell differentiation in avian lymphoid leukosis: production of heterogeneous IgM by tumor cells.


Studies on the influence of calcium in the anaphylactic histamine release from isolated rat mast cells.


Studies on the status of arginine residues in cobrotoxin.


Studies on transforming activities from human solid tumor cells following co-cultivation with human leukemic bone marrow cells.


Surface coats of the mouse blastocyst and uterus during the preimplantation period.


Surface immunoglobulins of rat immunocytes: quantitation and fate of cell-bound peroxidase-labeled antibody and Fab fragment.


Surface structure of mouse mammary tumor virus.


Synthesis of DNA complementary to cellular slime mold messenger RNA by reverse transcriptase.


Survey of recent studies on mechanism and significance of delayed (cellular)-type hypersensitivity.


Teacher and distinguished pupil: William Henry Welch and George Hoyt Whipple.


Teaching medical-surgical nursing by concepts.


Systematics of RNA tumor viruses and virus-like particles of human origin. [(3)H]DNA copies of avian, feline, murine, and primate RNA tumor virus genomes were synthesized in vitro by an RNA-dependent DNA polymerase reaction. These DNAs were hybridized to 60-70S RNA that had been purified from the viruses. The amount of the [(3)H]DNA hybridized yielded a measure of the genetic relatedness among the DNA preparations synthesized by the viruses. When many combinations of DNA and RNA were analyzed, the pattern of hybridization showed in some cases that the DNA copies of the viral RNA were related to each other in the same way that the natural hosts of the viruses are phylogenetically related. This pattern was observed only among the RNA leukemia viruses. The sarcoma component in sarcoma-leukemia viruses from rats and primates appeared to be unusually closely related. The mouse mammary carcinoma virus and two unclassified viruses (MPMV and Visna) appeared to be genetically distinct.A similar analysis of DNA synthesized by an RNA-dependent DNA polymerase associated with a viral-like particle obtained from the cytoplasm of human leukemic white blood cells demonstrated that this DNA occupied a space in the affinity pattern of leukemia viruses which is expected of a nucleic acid from a primate-type-C RNA tumor virus. This observation strengthens earlier evidence that components of RNA tumor viruses are associated with human leukemia.


Tensile yield in bone.

Tensile yield in bone.


Testing the potency of smallpox vaccines, anti-smallpox immune sera and immunoglobulins with the use of own reference vaccine and standard immunoglobulin.


The action of nicotinamide on the release of histamine.


The active sites of immunoglobulin molecules.


The antigenic determinant of fibrin(ogen) measured with agglutination inhibition immunoassays. Agglutination inhibition immunoassays using antifibrinogen antiserum measure an antigenic determinant of fibrinogen which is located on the fragment D parts of this molecule. This antigenic determinant of fragment D, in contrast to others, does not form an immune precipitate with antifibrinogen antiserum. Upon very extensive hydrolysis by plasmin, this antigenic determinant has a reduced affinity for its antibody.


The binding of asialo-glycoprotein to isolated Golgi apparatus.


The cellular and molecular basis of immunological tolerance.


The alpha2-macroglobulin level in cerebrospinal fluid; a parameter for the condition of the blood-CSF barrier.


The chemical elements and human morbidity--water, air and places--a study of natural variability.


The complexity of the HL-A gene product I: study of a serum produced against HL-A5 in an HL-A semi-identical situation.


The diagnostic value of the NBT-test in the case of febrile diseases.


The encephalitogenic dose response in guinea pigs of the tryptophan region of myelin basic protein.


The establishment of systemic immunity following antigenic stimulation of the lymphoid tissue of the gastrointestinal mucosa.


The fetus at risk.

The fetus at risk.


The genetic control of the immune response to different antigenic determinants within the synthetic polypeptide poly(His, Glu)-polyPro-polyLys.


The hemocytes of an lsopod Ligia exotica Roux.


The hemocytes of a scorpion Palamnaeus swammerdami.


The hinge peptide of an IgA2m(2) myeloma protein.


The induction and characterization of secretory IgA antibodies.


The innervation of the trapezius muscle. An electrophysiological study.


The karyotype of the pig.

The karyotype of the pig.


The lack of estrogen binding by human alpha-fetoprotein.


The management of chronic pain syndromes in the upper extremity.


The mechanism of the inhibitory action of zinc on histamine release from mast cells by compound 48-80,.


The mechanism of breakdown of immune tolerance to a protein antigen in rabbits.


The natural mediator for PMN emigration in inflammation. II. Common antigenicity of leucoegresin with immunoglobulin G.


The nature of nuclear ribonucleoprotein particles containing virus-specific RNA.


The natural mediator for PMN emigration in inflammation. 3. In vitro production of a chemotactic factor by inflammatory SH-dependent protease from serum immunoglobulin G.


The nephropathy of experimental hepatosplenic schistosomiasis. The glomerular lesions induced in 10 chimpanzees infected with variable numbers of Schistosoma japonicum cercariae were studied by means of light and electron microscopy and fluorescent antibody technic. Ten animals served as controls; 5 were uninfected and 5 were only lightly infected. The animals were observed for periods ranging from 3 to 17 months, and by the time of sacrifice, all had developed advanced liver fibrosis. In general, the degree of glomerular injury was related to infection intensity and degree and duration of portal liver fibrosis. Some animals had terminal BUN elevation and slight proteinuria. By light and electron microscopy, in the initial stages, only part of the glomeruli were involved and exhibited mesangial matrix expansion and mesangial cell proliferation with intracellular hyaline droplets. At later stages, a larger number of glomeruli were affected and exhibited diffuse hypercellularity, glomerular basement thickening, mesangial sclerosis and less often, focal necrosis, crescent formation, synechiae and global hyalinization. In addition, there were discrete electron-dense deposits localized in the mesangial area in some glomeruli. Immunofluorescent studies utilizing antisera to chimpanzee gamma-globulin and complement (C3) and to human properdin disclosed only faint deposits of C3, apparently in mesangial areas. The association of hepatosplenic schistosomiasis and nephropathy, the possible role of schistosomal antigen and the mechanism(s) of such glomerular injuries are reviewed and compared with the disease in humans and other host species infected with Schistosoma.


The neuronal organization of cerebellar lobe C1 in the mormyrid fish Gnathonemus Petersii (teleostei).


The nephrotic syndrome of infancy.

The nephrotic syndrome of infancy.


The production of experimental glomerulonephritis in the rat.


The origin of monomeric and polymeric forms of IgA in man.


The rat mast cell degranulation assay as an in vitro allergy test.


The relationship between changes in cell wall composition and the establishment of polarity in Fucus embryos.


The relationship of ventricular asynergy in coronary artery disease to ventricular premature beats.


The relevance of RNA tumor viruses to human cancer.


The role of cellular interaction in differentiating between the occurrence of immunological tolerance and immunity following antigenic challenge.


The search for meaning in renal transplantation.


The social world of individuals.

The social world of individuals.


The staining pattern of collagen fibrils. I. An analysis of electron micrographs.


The staining pattern of collagen fibrils. II. A comparison with patterns computer-generated from the amino acid sequence.


The structure of rat liver mitochondria: a reevaluation.


The rise of the filtering operations.

The rise of the filtering operations.


The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies. To explore the possibility that the affinity of some myeloma proteins for 2,4-dinitrophenyl (DNP) ligands is the consequence of a "strange" (i.e., unexpected) cross-reaction for more natural ligands, a variety of substances (primarily derivatives of purines, pyrimidines, naphthaquinone) were tested for ability to block the binding of [(3)H]-epsilon-DNP-L-lysine by protein 315, an IgA mouse myeloma protein with high affinity for DNP ligands. The most impressive inhibiting activity was observed with 2-methyl-1,4-napthaquinone (menadione, vitamin K(3)). The affinity (intrinsic association constant) of protein 315 for menadione was 5 x 10(5) L/M (at 4 degrees C). Because the same affinity was measured in direct-binding assays (e.g., equilibrium dialysis) and in an indirect one based on the assumption of competitive binding with DNP-lysine, it is likely that menadione and DNP bind at overlapping sites in the protein's combining region. This conclusion is supported by molecular models which reveal some common structural features in these ligands. Hence it is not surprising that antinitrophenyl antibody preparations, raised by conventional immunization procedures (anti-2,4-DNP; anti-2,6-DNP; anti-2,4,6-TNP) also bind menadione with considerable affinity. As with DNP ligands, when menadione binds to protein 315 or to conventional antinitrophenyl antibodies, some of the protein's tryptophan fluorescence is quenched, there is a change in the ligand's absorption spectrum (hypochromia and/or red shift), and the binding is temperature-dependent (exothermal).


The susceptibility of the fetus and child to chemical pollutants. Chemicals in human teratogenesis and transplacental carcinogenesis.


The sliding lens paradox or the unexpected effect of longitudinal ("to-and-fro") motion of plus spectacle lenses. A treatise on lens effectivity.


The susceptibility of the fetus and child to chemical pollutants. Nature and sources of pollutants.


The ultrastructure and permeability for colloidal carbon of intestinal submucosal arterioles in rats.


The use of a sensitive micronephelometer in the estimation of antigens and precipitating antibodies.


The uninvolved psoriatic epidermis.

The uninvolved psoriatic epidermis.


The use of the basic fuchsin stain in the recognition of early myocardial ischaemia.


The value of the morphological and enzyme histochemical investigation in ovarian biopsies of twenty-two patients with menstrual disorders.


The vestibular aqueduct and the para-vestibular canal. An anatomic and roentgenologic investigation.


Three contributions of lectins to the understanding of specific agglutination and precipitation.


The IgA antibody-forming cell response in the rabbit submandibular gland following several different methods of immunization.


Three-dimensional reconstruction of the pericellular nests (baskets) of the motor (area 4) and visual (area 17) areas of the human cerebral cortex. A Golgi study.


Topology of the outer segment membranes of retinal rods and cones revealed by a fluorescent probe. When N,N'-didansyl cystine binds to the cell membranes of vertebrate rods and cones its fluorescence efficiency increases about 20-fold. The entire outer segments of living cones become brilliantly fluorescent. Stained live rods, as well as most freshly detached outer segments, are only weakly fluorescent, but they become brightly fluorescent within a few seconds if their plasma membranes are osmotically ruptured. The difference in staining of rod and cones suggests that disk membranes of rods are not continuous with the plasma membranes are osmotically ruptured. The difference in staining of rod and cones plasma membrane on outer segments of photoreceptors in electrophysiological and biochemical experiments, and to study the infolding pattern of rod and cone disks.


Transcription and translation of viral RNA in cells transformed by RNA tumor viruses.


Transfer of delayed hypersensitivity in rats.


Transmission of proteins from mother to conceptus in the grey squirrel (Sciurus carolinensis).


Transumbilical balloon atrial septostomy in 16 infants with transposition of the great arteries.


Triple pathway for induction of chemotaxis in neutrophil leucocytes by guinea-pig immune complexes of different Ig classes.


Treatment of urinary retention.

Treatment of urinary retention. In 50 patients retention of urine due to adenomatous enlargement of the prostate was relieved, in most cases by intraprostatic injections given for varying periods of time. No complications were encountered. Subsequently, some of the patients who did not respond adequately, and whose medical conditions improved, underwent prostateceomy. Histologically the removed prostates showed coagulation necrosis, with or without haemorrhage, but no inflammatory reaction.


Tumor growth in the guinea pig: alpha globulin changes associated with lymphocyte suppression.


Type C viruses of baboons: isolation from normal cell cultures.


Type-specific antibodies in human Chlamydia trachomatis infections of the eye.


U.S. citizens studying medicine abroad.

U.S. citizens studying medicine abroad.


Ultrastructural localization of cholinesterase activity in the developing rat retina.


Ultrastructural staining of thin sections with iron hematoxylin.


Ultrastructure of bile canaliculi, with special reference to the surface coat and the pericanalicular web.


Ultrastructure of the erythrocytes in beta-thalassemia.


Usefulness of blood levels of antiepileptic drugs.


Visceral viewpoints. My kingdom for a camera--some comments on medical technology.


Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture, 1973.


Visualization of deoxyribonucleic acid molecules by protein film adsorption and tantalum-tungsten shadowing.


Vitamin K and the biosynthesis of prothrombin. IV. Isolation of peptides containing prosthetic groups from normal prothrombin and the corresponding peptides from dicoumarol-induced prothrombin.


Whipple disease: light and electron microscopy study.


Why admit abortion patients?

Why admit abortion patients?


17-beta-oestradiol and the fibrinolytic activity on vein walls. 16 postmenopausal women were studied for fibrinolytic activity before and after treatment of 10 mg daily of 17-beta-estradiol by blood samples, and vein biopsies.  Fibrinolytic activity in vein biopisies did not change during treatment; plasminogen, urikinase inhibitors and alpha-2-macroglobulin also remained unchanged.  Antithrombin 3 decreased from 105% to 90% (p.01), prothrombin and Factor 7 plus Factor 10 increased 9% (p.01), Factor 5 decreased 12%, Factor 7 decreased and Factor 8 increased 29% (p.05).  It is concluded that 17-beta-estradiol a naturally-occurring estrogen, may be safer than synthestic estrogens for postmenopausal substitution therapy.


12-(9-Anthroyl)-stearic acid and atebrin as fluorescence probes for energetic states of chloroplasts.


Uses and abuses of thyroid function tests.


Case against the use of d-tubocurarine in operant studies of the cardiovascular system.


Fast and simple identification of adipose tissues in situ with dithizon.


Test and teach number one. Myxoid liposarcoma of the thigh.


Diet and the geographical distribution of multiple sclerosis.


Some aspects of the release of the adrenergic transmitter.


Cell border demarcation in the scanning electron microscope by silver stains.


Mast cell population density in hamster gingiva.


Some characteristics of the immune response to sporozoites of simian and human malaria.


Time course of histamine release and edema formation in the rat paw after thermal injury.


High frequency of T lineage lymphocytes in nude mouse spleen.


Cold lability of Bacillus cereus bacteriophage CP-51. Phage CP-51 was rapidly inactivated when stored at the usual refrigerator temperatures (2 to 4 C) and even more rapidly when exposed to 0 C. The loss in viability resulting from exposure to cold appeared to correlate with the increase in number of phage particles having contracted tails. High concentrations (0.01 M) of Mg(2+), Ca(2+), or Mn(2+) stabilized the phage considerably, but even in the presence of these divalent cations, it was much less stable at 0 C than at 15 C.


Role of energy metabolism in histamine release. A study on isolated rat mast cells.


Role of the compensatory pause in the production of concealed bigeminy.


Role of H-2 lymphocyte-defined and serologically-defined components in the generation of cytotoxic lymphocytes. The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is determined by lymphocyte-defined (LD) and serologically-defined (SD) antigenic differences present during sensitization. Cells which are activated by LD differences alone are markedly less effective in causing lysis of target cells. This lack of cytotoxicity is shown to be, at least in part, due to the inability of LD differences to allow the efficient generation of cytotoxic lymphocytes. SD antigens not only serve as good targets for CML but are also shown to be important for the generation of cytotoxic lymphocytes during the mixed lymphocyte culture.


Disc gel electrophoresis. A technique involving fluorescent staining prior to separation.


Left or right hepatic duct?

Left or right hepatic duct?


Role of T lymphocytes in the humoral immune response. I. Proliferation of B lymphocytes in thymus-deprived mice.


Skin prolyl hydroxylase in patients with obstructive jaundice.


Side reactions of chloramphenicol in mouse erythroblasts.


Late results following cryosurgery of the prostate in 97 high risk patients.


Cell surface modification in the treatment of experimental cancer: neuraminidase or concanavalin A.


Zinc therapy in acrodermatitis enteropathica.


Late urinary-tract infection after renal transplantation.


1975 National Children's Dental Health Week special aids. Bureau of Dental Health Education.


Cost-effectiveness relationships in odor control.


Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies.


Cell-mediated autohypersensitivity in psoriasis. In vitro tests with extracts from psoriatic skin and scales.


Long-term assessment of cyclophosphamide therapy for nephrosis in children.


Long-time treatment of intermittent claudication with vitamin E.


Long-term oral antiarrhythmic therapy with aprindine (AC 1802).


Anti-T agglutinin in cirrhosis of the liver.


User's guide to some new tests for hepatitis-B antigen.


The "Doctoress" on a donkey: women health officers in nineteenth century Egypt.


Visna and maedi viruses in tissue culture.


Gamma globulins in pre-colostral piglet serum.


Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury.


"Catabolic" loss of body nitrogen in response to surgery.


Collaborative study of the determination of Geotrichum mold in selected canned fruits and vegetables.


Intracellular accumulation of oncornaviruses in continous human cell lines.


Coxsackie B4 viruses and atrial myxoma.

Coxsackie B4 viruses and atrial myxoma.


Characterization of human carcinoembryonic antigens.


Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine.


Characterization of reverse transcriptase and RNase H from friend-murine leukemia virus.


Characterization of the antibody production in rabbits induced by streptococcal group A and C carbohydrate antigens. I. Evidence for lact of correlation between magnitude of immune response, degree of antibody restriction, and immunoglogulin allotype.


Characterization of the antibody production in rabbits induced by streptococcal group A and C carbohydrate antigens. II. Evidence that the appearance of an antibody response of restricted heterogeneity is accompanied by an anti-antibody production.


Characterization of R-type vitamin B12-binding proteins by isoelectric focusing. I. The relationship between transcobalamin I, transcobalamin III and the granulocyte R protein.


Glucagon control of fasting glucose in man.


On waking screens.

On waking screens.


Explaining the unexpected abnormal results of biochemical profile investigations.


Medial pulvinar afferents to frontal eye fields in rhesus monkey demonstrated by horseradish peroxidase.


Foetal origin of transferrin in mouse amniotic fluid.


Prevalence and prognostic value of ventricular dysrhythmias in patients with healed myocardial infarction.


Mortality in areas containing natural fluoride in their water supplies, taking account of socioenvironmental factors and water hardness.


Histamine content of tracheal and lung tissue as a function of age in rats.


Histamine release from isolated rat mast cells due to glycoprotein from Candida albicans in vitro.


Histamine storage and release.

Histamine storage and release.


RNA and DNA forms of the genetic material of C-type viruses and the integrated state of the DNA form in the cellular chromosome.


Variant (Prinzmetal's) form of angina pectoris manifesting in complicating ventricular extrasystoles.


Rectal carcinoid and rectal adenocarcinoma: a case report and review of the literature.


Intraocular use of butyl-2-cyanoacrylate in retinal detachment surgery. A preliminary report.


The application of acridine orange staining to quantitate low levels of Babesia divergens parasitaemias.


Therapeutic effectiveness and plasma levels of a new antidysrhythmic drug: aprindine.


Comparative study of 240 cases of cryosurgery using nitrogen protoxide and liquid nitrogen as coolant.


Comparative investigation of protein concentration in serum and synovial fluid.


Margaret Mary Basden.

Margaret Mary Basden.


Release of skin reactive factor by human lymphocytes. An in vitro correlate of cellular immunity.


New aspects of oriented binding of diazo complexes on amyloid fibrils and other fibrillar protein structures.


The assay of urinary thyroid hormones for assessing thyroid function.


Ultrastructural changes in the normal human lens capsule from birth to old age.


Ultrastructural studies of the argyrophil reaction in alpha1 cells in human pancreatic islets.


Ultrastructural study of epithelial and connective gingival reattachment in man.


Primary amyloidosis with polyneuropathy. Some aspects on the histopathological diagnosis ante mortem based on studies of biopsy specimens from 30 familial and non-familial cases.


Ultrastucture of the surface of Rickettsia prowazeki and Rickettsia akari. Negative-contrast electron microscopy revealed that the outer layer of the envelope of rickettsiae is composed of a matrix of tetragonally arranged subunits. The layer projects approximately 7 nm from the cell wall. It is suggested that this outer layer is analogous to the structure considered capsule-like in morphology.


Sulfated acid mucopolysaccharides in the cortical granules of eggs. Effects of quaternary ammonium salts on fertilization.


The ataxic (cerebellar) form of Creutzfeldt-Jakob disease.


Isolation of plant nuclei.

Isolation of plant nuclei.


Isolation and identification of soluble skin-reactive membrane antigens of malignant and normal human breast cells.


Isolation of plasma membrane from tissue culture--L cells.


Isolation and characterization of Golgi apparatus and membranes from rat liver.


Isolation of epidermal desmosomes.

Isolation of epidermal desmosomes. A method is reported for the isolation of desmosomes in a high yield and of a purity suitable for biochemical analysis. The procedure utilizes the selective solubilizing action of citric acid-sodium citrate (CASC) buffer, pH 2.6, on the non-cornified layers of cow nose epidermis, followed by discontinuous sucrose density gradient centrifugation. Electron microscopy with both thin sections of pellets and unfixed spread preparations reveals that after centrifugation, desmosomes are located mainly at the 55-60% sucrose interface. In the desmosome preparation thus obtained, the characteristic desmosome structure is well preserved, showing the midline, unit membranes, and dense plaques. Furthermore, removal of the epidermal filament bundles by the solubilizing action of CASC buffer has revealed a finely filamentous layer on the cytoplasmic surface of the plaques. The dimensions, location, and appearance of this layer correspond with those of the "connecting component" which has been previously suggested as being responsible for the attachment of epidermal filament bundles to the desmosome.


Isolation of plasma membranes from intestinal brush borders.


Isolation of postsynaptic densities from rat brain. Most synapses in the central nervous system exhibit a prominent electron-opaque specialization of the postsynaptic plasma membrane called the postsynaptic density (PSD). We have developed a procedure for the isolation of PSDs which is based on their buoyant density and their insolubility in N-lauroyl sarcosinate. Treatment of synaptic membranes with this detergent solubilizes most plasma membranes and detaches PSDs from the plasma membrane so that they can be purified on a density gradient. Isolated PSDs appear structurally intact and exhibit those properties which characterize them in tissue. The isolated PSDs are of the size, shape, and electron opacity of those seen in tissue; they stain with both ethanolic phosphotungstic acid and bismuth iodide-uranyl lead and the fraction contains cyclic 3',5'-phosphodiesterase activity. Quantitative electron microscope analysis of the PSD fraction gives an estimated purity of better than 85%. Inasmuch as the PSD is associated primarily with dendritic excitatory synapses, our PSD fraction represents the distinctive plasma membrane specialization of this specific synaptic type in isolation.


Premature ventricular contraction. Part 1. Clinical significance.


Dermatological hypersensitivity to thiacetazone.


A biblical case of hypothermia-resuscitation by rewarming (Elisha's method).


Inhibition of testosterone metabolism in the human prostate. The conversion of carbon-14-testosterone (T) to 5alpha-dihydrotestosterone (DHT) and androstanediol (A-diol) was studied in vitro using a crude homogenate of prostate from patients with benign prostatic hypertrophy.  Under standard conditions, the mean conversion to DHT was 70 + or -1 (standare error, SE)% and to A-diol 14 + or -1 (SE)%.  Addition of various antiandrogens and other substances decreased the T to DHT conversion to 0-55% and the T to A-diol to 0-10%.  The most potent inhibitors were desoxycorticosterone and progesterone.  Estradiol-17beta, cyproterone acetate, medrogestone, medroxyprogesterone acetate, estriol and 4'-nitro-3'trifluoromethylisobutyramilide were also effective inhibotors.  To determine whether this effect might be significant in vivo, similar conversion studies were carried out on prostatic tissue obtained from 3 patients who had received oral medrogestone for 1-2 weeks.  T to DHT was reduced to 12.2 + or -2.8 (SE)% and T to A-diol to 6.5 + or -1.0 (SE)%.  The ability of such compounds to inhibit DHT formation represents 1 mode of action which may account at least in part for their efficacy in the treatment of benign prostatic hypertrophy.


Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.


Metabolic aspects of spontaneous rewarming in accidental hypothermia and hypothermic myxoedema.


Cerebral blood flow and quantitative rheoencephalography.


Urticaria.

Urticaria.


Thiacetazone induced Steven-Johnson syndrome: a case report.


RNA-bound reverse transcriptase in Escherichia coli and in vitro synthesis of a complementary DNA.


The claustrum and the transitional neo-paleocortical area of the hedgehog (Erinaceus europaeus).


The combined use of high efficiency liquid and capillary gas chromatography for the determination of polycyclic aromatic hydrocarbons in automotive exhaust condensates and other hydrocarbon mixtures.


New concepts and developments in applied diagnostic virology.


Endocrine-like cells in rat stomach: effects of 6-hydroxydopa on amine stores and amino acid decarboxylase activities. A chemical, fluorescence histochemical and electron microscopic study.


Effect of buffer storage on fine structure and catalase cytochemistry of peroxisomes.


Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve.


Effect of prolonged beta-receptor blockade on dry weight and electrophysiological responses of rabbit hearts.


Effect of severe, chronic illness on thyroid function.


Detection of "C" type-oncornaviruses of cattle with spontaneous and with experimentally induced lymphatic leukemia.


Detection of a specific antigen of amyloid fibrils in mice.


Rejection of tumor transplants after incubation in alkylated diffusion chambers.


Detection of human reagins with rat peritoneal mast cells by histamine release.


Infections caused by Pseudomonas species in patients with burns and in other surgical patients.


Selective histochemical staining of cartilage matrix by Rivanol.


Galactose neurotoxicity in chicks: effects on fast axoplasmic transport.


Aspects of the Odland bodies in the synthesis of keratohyalin.


Structural and eletrophysiological properties of nymphal and adult insect medial neurosecretory cells: an in vitro analysis.


Effects of 25-hydroxycholecalciferol on urinary electrolyte excretion in hypophosphataemic rickets.


Effects of repetitive stimulation on membrane potentials and twitch in human and rat intercostal muscle fibres.


Structural proteins associated with ribosomal cistrons in Xenopus laevis chromosomes.


Structure antigenicity relationships of glucagon and related peptides.


Pediculosis today.

Pediculosis today.


Structure of infectious bursal disease virus. Infectious bursal disease virus of chickens was purified, and its structure was examined by the negative-staining technique in the electron microscope. The buoyant density of infectious bursal disease virus in CsCl was found to be 1.34 g/cm(3). The morphological details suggest that the capsid of the virion consists of a single layer of 32 capsomeres arranged in 5:3:2 symmetry. The virion measured about 55 nm in diameter and had no envelope.


The cytochemical bioassay of ACTH.

The cytochemical bioassay of ACTH.


Effects of freezing in the presence of beta-mercaptoethanol on the antigenicity of peanut proteins.


Solid phase radioimmunoassay for identification of Herpesvirus hominis types 1 and 2 from clinical materials. A solid phase radioimmunoassay (RIA) was developed for typing Herpesvirus hominis (HVH) strains isolated from clinical materials, and it also proved to be applicable to the direct detection and typing of HVH antigen in human and animal brain tissue. The procedure utilized virus-infected human fetal diploid cells or brain tissue smears in the bottom of 1-dram glass vials, antigen was detected through the use of intermediate HVH antisera produced in rabbits or hamsters and cross-absorbed with the HVH heterotype, and (125)I-labeled anti-species (rabbit or hamster) globulins produced in goats were used for detection of immune complexes. The cross-absorbed HVH antisera could be used at high dilutions in the RIA test, and they reacted with marked type-specificity in the RIA system. Specificity of the test was also improved by determining and using optimal concentrations of intermediate sera and of (125)I-labeled anti-species globulins. Results of typing HVH isolates by the RIA procedure agreed in all instances with those obtained by direct fluorescent antibody staining with cross-absorbed conjugates. The RIA procedure was effective and more sensitive than direct fluorescent antibody for demonstrating and typing HVH antigen directly in smears of infected human brain tissue.


Blood-group serology of fractions obtained from the human erythrocyte membrane.


Acrodermatitis enteropathica. Report of a case healed with zinc therapy.


Incidence and meaning of the "e" determinant among hepatitis-B-antigen positive patients with acute and chronic liver diseases. Report from the Copenhagen Hepatitis Acuta Programme.


The development of secondary epileptic discharges in the rhesus monkey after commissure section.


T and B lymphocytes in systemic lupus erythematosus.


A modified rotary L.E.-cell method for enhancing L.E.-cell production.


Hereditary transcobalamin II deficiency: clinical findings in a new family.


Dihydrostreptomycin accumulation in E. coli.


Acute epidermal necrolysis (Lyell syndrome) induced by thiacetazone.


Three ways of using immunology to investigate the cell surface: cocapping, helper determinants and immunogenicity.


Acute phase reaction following intravenous administration of streptokinase.


Stage D prostatic carcinoma. Survival rate in relapsed patients following new forms of palliation.


Three-dimensional ultrastructure of the crayfish neuromuscular apparatus. The synapse-bearing nerve terminals of the opener muscle of the crayfish Procambarus were reconstructed using electron micrographs of regions which had been serially sectioned. The branching patterns of the terminals of excitatory and inhibitory axons and the locations and sizes of neuromuscular and axo-axonal synapses were studied. Excitatory and inhibitory synapses could be distinguished not only on the basis of differences in synaptic vesicles, but also by a difference in density of pre- and postsynaptic membranes. Synapses of both axons usually had one or more sharply localized presynaptic "dense bodies" around which synaptic vesicles appeared to cluster. Some synapses did not have the dense bodies. These structures may be involved in the physiological activity of the synapse. Excitatory axon terminals had more synapses, and a larger percentage of terminal surface area devoted to synaptic contacts, than inhibitory axon terminals. However, the largest synapses of the inhibitory axon exceeded in surface area those of the excitatory axon. Both axons had many side branches coming from the main terminal; often, the side branches were joined to the main terminal by narrow necks. A greater percentage of surface area was devoted to synapses in side branches than in the main terminal. Only a small fraction of total surface area was devoted to axo-axonal synapses, but these were often located at narrow necks or constrictions of the excitatory axon. This arrangement would result in effective blockage of spike invasion of regions of the terminal distal to the synapse, and would allow relatively few synapses to exert a powerful effect on transmitter release from the excitatory axon. A hypothesis to account for the development of the neuromuscular apparatus is presented, in which it is suggested that production of new synapses is more important than enlargement of old ones as a mechanism for allowing the axon to adjust transmitter output to the functional needs of the muscle.


Increase of T lymphocytes in the spleen in Hodgkin's disease.


New drugs of 1973.

New drugs of 1973.


Proceedings: Changes in response to chemotherapeutic agents during ther life history of monolayer cultures of a mouse tumour cell line.


Proceedings: Histamine output from the rat gastric mucosa during stimulation and inhibition of acid secretion.


Proceedings: The surface ultrastructure of exfoliated cervical cells.


The effect of electric stimulation on the axoplasmic transport of newly synthetized neuronal proteins.


The effect of betamethasone valerate on seborrhoeic dermatitis of the scalp. A clinical, histopathological cell kinetic study.


The effect of cationic triphenylmethane dye (crystal violet) on rabbit granulation tissue. Oxygen consumption and RNA and protein synthesis in tissue slices.


The effect of pseudopregnancy, induced with a combination of mestranol and chlormadinone acetate, on carbohydrate metabolism and nonesterified fatty acid level.


The effect of erythrocyte antigen structure on requirement for T cells.


Samuel Norman Lytle.

Samuel Norman Lytle.


A preliminary report of a rapid method for the demonstration of abnormal gammaglobulin levels in bovine whole blood.


Subcellular fractionation of rat liver.

Subcellular fractionation of rat liver.


System and crisis: a psychosomatic model of human development.


Schlemm's canal and scleral spur in normal and glaucomatous eyes.


Evidence for a rapid phase of axoplasmic transport at early stages in the development of the visual system of the chick and frog.


Evidence for inapparent rabies infection.


Presenile dementia: further experience with an anticoagulant-psychotherapy regimen.


Screening for disease: Definitions and criteria.


Current activites of the APS Education Committee.


Prevention of deep-vein thrombosis by low-dose heparin in patients undergoing total hip replacement.


Letter: "Rotavirus" in stored specimens of faecal extracts.


Letter:  L.A.T.S. and Graves' disease.

Letter:  L.A.T.S. and Graves' disease.


Letter: "Self" versus "non-self": in situ proteins.


Letter: A radioimmunoassay for serum-alpha-fetoprotein based on commercial antisera.


Letter: Acid-base diagrams.

Letter: Acid-base diagrams.


Letter: Acetylcholine poisoning and sympathetic overactivity in tetanus.


Letter: Action of cysteamine in paracetamol poisoning.


Letter: Activation or unblocking of T lymphocytes.


Letter: Acupuncture for drug addiction.

Letter: Acupuncture for drug addiction.


Letter: Acute arthralgia after high-dose intravenous methylprednisolone.


Letter: Ampicillin-resistant haemophilus influenzae.


Letter: An evolutionary theory of premenstrual tension.


Letter: Aetiology of Crohn's disease.

Letter: Aetiology of Crohn's disease.


Letter: Anatomy of hepatic duct.

Letter: Anatomy of hepatic duct.


Letter: Angina pectoris with normal coronary arteries.


Letter: Antigenicity of "monocomponent" insulins.


Letter: Arachidonic acid and platelet aggregation.


Letter: Ascorbic acid in treatment of pressure-sores.


Letter: Atypical lymphocytes in infectious mononucleosis.


Letter: B.A.L. in paracetamol poisoning.


Letter: Basic encephalitogen and unresponsive multiple sclerosis.


Letter: Beclomethasone aerosol in chronic bronchial asthma.


Letter: Beta-adrenergic blockade in the treatment of M.A.O.I. self-poisoning.


Letter: Blue eyedrops.

Letter: Blue eyedrops.


Letter: Candicidin for benign prostatic hypertrophy.


Letter: Cellular immunity in minimal-lesion nephrosis.


Letter: Care of the critically ill.

Letter: Care of the critically ill.


Letter: Changing pattern of antenatal diagnosis.


Letter: Chlorpropamide in diabetic pregnancy.


Letter: Chondroitinsulphaturia with alpha-L-iduronidase deficiency.


Letter: Classification of non-Hodgkin's lymphomas.


Letter: Clinical trials with vitamin C.

Letter: Clinical trials with vitamin C.


Letter: Comparison between free thyroxine index and effective thyroxine ratio.


Letter: Controlled-environment treatment for postoperative management of wounds.


Letter: Cot deaths.

Letter: Cot deaths.


Letter: Computers in intensive care.

Letter: Computers in intensive care.


Letter: Countercurrent immunoelectrophoresis for rapid diagnosis of dengue haemorrhagic fever.


Letter: Cyclic A.M.P. and morphine analgesia.


Letter: Defibrination and head injury.

Letter: Defibrination and head injury.


Letter: Diet and cardiovascular disease.


Letter: Down with parameters.

Letter: Down with parameters.


Letter: Diabetes in pregnancy.

Letter: Diabetes in pregnancy.


Letter: Dopamine-beta-hydroxylase and sympatho-adrenal activity.


Letter: E-aminocaproic acid and subarachnoid haemorrhage.


Letter: E-rosette test.

Letter: E-rosette test.


Letter: Endoscopy in gastrointestinal bleeding.


Letter: Efficacy of influenza vaccines.

Letter: Efficacy of influenza vaccines.


Letter: Environmental stress and thyrotoxicosis.


Letter: Epsilon-aminocaproic acid and subarachnoid haemorrhage.?211.


Letter: Estimation of blood-carboxyhaemoglobin.


Letter: Evans Blue counterstain for immunofluorescence.


Letter: Evitable injuries.

Letter: Evitable injuries.


Letter: Exercise and myocardial infarction.


Letter: Factor VIII in von Willebrand's disease.


Letter: Failure of "adequate" penicillin therapy to prevent bacterial endocarditis after tooth extraction.


Letter: False-positives.

Letter: False-positives.


Letter: Fluid balance after major surgery in chronic renal failure.


Letter: Food antibodies and myocardial infarction.


LEtter: Food antibodies and myocardial infarction.


Letter: Granular dystrophy of the cornea.


Letter: Glycosuria and hyperglycaemia after kidney transplantation.


Letter: Haloperidol, thyrotoxicosis, and neurotoxicity.


Letter: Health services in Chile.

Letter: Health services in Chile.


Letter: Hepatitis-B antigen in vaginal secretions.


Letter: Hepatitis-B surface antigen in breast milk.


Letter: High avidity antibody in long-term survivors of acute leukaemia.


Letter: Histological changes following chemical face peeling.


Letter: Homocarnosinosis: a new metabolic disorder associated with spasticity and mental retardation.


Letter: Hurler's syndrome with clear corneas.


Letter: Immunodeficiency in the cerebro-hepato-renal syndrome of Zellweger.


Letter: Hypothermic total body-washout with survival in Reye's syndrome.


Letter: Immunohistochemical localization of complement in intestinal mucosa.


Letter: Increase of premalignant cervical lesions in teenagers.


Letter: Insulin suppression.

Letter: Insulin suppression.


Letter: Intellectual function after head injury.


Letter: In-vitro detection of hypersensitivity to antituberculous drugs.


Letter: Intestinal potential difference during glucose absorption.


Letter: Intrauterine device, prostaglandins and copper.


Letter: Jack becomes master.

Letter: Jack becomes master.


Letter: Jack becomes master?

Letter: Jack becomes master?


Letter: Late urinary-tract infection after renal transplantation.


Letter: Low carbon-monoxide cigarettes.

Letter: Low carbon-monoxide cigarettes.


Letter: Lithium and magnesium-dependent enzymes.


Letter: Low-dose heparin and stress ulceration.


Letter: Lower-motor-neurone disease in mice and amyotrophic lateral sclerosis in man.


Letter: Lymphocyte function and iron-deficiency anaemia.


Letter: Lymphocyte-membrane adenosine triphosphatase.


Letter: Lymphocytes in common variable (adult "acquired") hypogammaglobulinaemia.


Letter: Mechanism of diarrhoea in cholera.


Letter: Mechanism of lactic acidosis.

Letter: Mechanism of lactic acidosis.


Letter: Meningococcal infection in London.


Letter: Membranous nephropathy and hepatitis-B antigen.


Letter: Minocycline: possible vestibular side-effects.


Letter: Missing sex chromosomes and translocations in acute leukaemia.


Letter: Monoamine-oxidase and migraine.

Letter: Monoamine-oxidase and migraine.


Letter: New concepts in medical education.


Letter: Multiple sclerosis and diet.

Letter: Multiple sclerosis and diet.


Letter: Non-specific enhancement of glomerular filtration by corticosteroids.


Letter: Non-treatment of hypertension.

Letter: Non-treatment of hypertension.


Letter: Nuclear projections in tumour cells.


Letter: Oral contraceptives and health.

Letter: Oral contraceptives and health.


Letter: Origin of alpha-fetoprotein.

Letter: Origin of alpha-fetoprotein.


Letter: Origin of malignant lymphomas.

Letter: Origin of malignant lymphomas.


Letter: Oral sodium cromoglycate in gastrointestinal allergy.


Letter: Oxolinic acid in urinary infections.


Letter: Oxygen-modified collagen and bone necrosis in divers.


Letter: Pathogenesis of coeliac sprue.

Letter: Pathogenesis of coeliac sprue.


Letter: Peak-flow meter versus peak-flow gauge.


Letter: Penicillamine and zinc.

Letter: Penicillamine and zinc.


Letter: Phenobarbitone and liver tumours.


Letter: Pitfalls in hepatitis A?

Letter: Pitfalls in hepatitis A?


Letter: Phenolphthalein in "aspirin".

Letter: Phenolphthalein in "aspirin".


Letter: Plasma-digoxin concentrations after an intravenous loading dose.


Letter: Plasma-prolactin in breast cancer.


Letter: Possible role of prostaglandins in idiopathic postural hypotension.


Letter: Portacaval shunt in familial hypercholesterolaemia.


Letter: Postoperative pulmonary embolism.


Letter: Predictive value of laboratory tests.


Letter: Prevention of bacterial endocarditis after tooth extraction.


Letter: Proportional mortality among vinyl-chloride workers.


Letter: Protein requirement.

Letter: Protein requirement.


Letter: Rapid diagnosis of Down's syndrome.


Letter: Rauwolfia derivatives and breast cancer.


Letter: Renal abnormality of essential hypertension.


Letter: Reserpine, prolactin, allergy, and breast cancer.


Letter: Satellite staining of human chromosomes.


Letter: Role of adrenergic nerves in ovulation and ovum transport.


Letter: Scanning electron microscopy in assessment of protein-calorie malnutrition.


Letter: Scanning electron microscopy of hairy cells in hairy-cell leukaemia.


Letter: Seasonal variation of histological osteomalacia in femoral-neck fractures.


Letter: Serum-creatine-kinase levels in carriers of Becker muscular dystrophy.


Letter: Serum-muramidase in leukaemic reticuloendotheliosis.


Letter: Skin prolyl hydroxylase.

Letter: Skin prolyl hydroxylase.


Letter: Skin wrinkling in cystic fibrosis.


Letter: Sleep and ventricular premature beats.


Letter: Smoking and lung cancer.

Letter: Smoking and lung cancer.


Letter: Smoking and the heart.

Letter: Smoking and the heart.


Letter: Sperm-induced lymphocyte transformation.


Letter: Spinal-fluid lysozyme in diagnosis of central-nervous-system tumours.


Letter: Spread of hepatitis in dialysis units.


Letter: Starch emboli in transplanted kidneys.


Letter: Subacute sclerosing panencephalitis in the Middle East.


Letter: SI units.

Letter: SI units.


Letter: Subcutaneous heparin.

Letter: Subcutaneous heparin.


Letter: Termination of first-trimester pregnancies.


Letter: T lymphocytes and immunoglobulins in the aged.


Letter: The great protein fiasco.

Letter: The great protein fiasco.


Letter: The benzodiazepine bonanza.

Letter: The benzodiazepine bonanza.


Letter: The nurse in the community.

Letter: The nurse in the community.


Letter: The pigeon as reservoir for cryptococcus neoformans.


Letter: The role of lay visitors in hospitals.


Letter: The spleen in Hodgkin's disease.


Letter: Toxic substances, synergism, and drinking-water.


Letter: The T lymphocyte and hepatitis.

Letter: The T lymphocyte and hepatitis.


Letter: Toxicity of dimethylformamide.

Letter: Toxicity of dimethylformamide.


Letter: Training of nurses.

Letter: Training of nurses.


Letter: Treatment of hypertension.

Letter: Treatment of hypertension.


Letter: Transient bacteraemia complicating peroral jejunal biopsy.


Letter: Treatment of lung cancer.

Letter: Treatment of lung cancer.


Letter: Treatment of thallium poisoning.


Letter: Tryptophan in depression.

Letter: Tryptophan in depression.


Letter: Twinning and neural-tube defects.


Letter: Virus-like particles in hepatitis-A-positive faecal extracts.


Letter: Vitamin-B12 deficiency.

Letter: Vitamin-B12 deficiency.


Letter: Unexplained tetanic spasms.

Letter: Unexplained tetanic spasms.


Letter: Wart-virus antibodies and multiple sclerosis.


Letter: White-cell glutathione reductase in cystic fibrosis.


Letter: Why admit abortion patients?

Letter: Why admit abortion patients?


Letter: Yersinia enterocolitica infection and thyroid disorders.


Differences in cell surface characteristics between glucocorticoid-sensitive and -resistant mouse lymphomas.