Mechanism of inactivation of L-glutamate dehydrogenase by pyridoxal and pyridoxal phosphate.


Relationships between personality dimensions: neuroticism and extraversion against obsessive, hysterical and oral personality.


Comparison of relative inotropic and chronotropic effects of propranolol, practolol, and sotalol.


Effects of calcium, isuprel and inderal on the calcitonin content of rat thyroid glands.


Reduction of pyridine nucleotides induced by adenosine diphosphate in kidney mitochondria. The influence of sodium, magnesium, and inhibitors of oxidative phosphorylation.


Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity.


Full time course studies on the oxidation of reduced coenzyme by bovine liver glutamate dehydrogenase. Use of computer simulation to obtain rate and dissociation constants.


Stringent control of fatty acid synthesis in Escherichia coli. Possible regulation of acetyl coenzyme A carboxylase by ppGpp.


Effects of splenectomy and beta-adrenoceptor blockade on cardiac output response to acute hypoxemia. Acute hypoxemia produced by the inhalation of 8% and 5% oxygen increased cardiac output in intact anesthetized dogs by 38% and 62%, respectively. Although practolol, a cardioselective beta-adrenergic blocking agent, reduced the increase in cardiac output in dogs subjected to severe hypoxemia (5% O(2) breathing) from 62% to 43%, it only slightly reduced the cardiac output rise in dogs subjected to moderate hypoxemia (8% O(2) breathing). Splenectomy, on the other hand, abolished the increase in cardiac output produced by moderate hypoxemia except for a small initial rise, but it reduced the increase in cardiac output during severe hypoxemia only to 37%. The entire increase, except for a small initial rise, disappeared only when splenectomized dogs were pretreated with practolol. Sham operation did not affect the cardiac output response to hypoxemia. It is concluded that an intact spleen is required for a significant portion of the increased cardiac output that occurs during both moderate and severe hypoxemia and that catecholamines do not participate in the regulation of cardiac output unless severe hypoxemia occurs.


Medical education and medical care in underserved rural areas.


Health care in rural New Mexico.

Health care in rural New Mexico.


Letter: Beta-blocking drugs.

Letter: Beta-blocking drugs.


Alteration of 5-hydroxytryptamine-14C efflux by nicotine in rat brain area slices.


Control of guanylate cyclase activity in the rod outer segment. Mammalian photoreceptors contain a guanylate cyclase which has a high specific activity and is inhibited by exposure of the rod outer segment to light. Several minutes are required for this inhibition to take effect, indicating that it is not a step in visual excitation. The activity of the enzyme is sensitive to the concentration of calcium ion in the medium, suggesting that light-induced changes in calcium distribution in the photoreceptor could control guanylate cyclase activity.


A kinetic assay of TPNH-dependent microsomal lipid peroxidation by changes in difference spectra.


Mechanism of enzyme action. VI. Kinetic isotope effect on D-amino acid oxidase reaction.


Complex formation between magnesium ions and pyridine nucleotide coenzymes.


Hyperproduction of dihydrofolate reductase in Diplococcus pneumoniae after mutation in the structural gene. Evidence for an effect at the level of transcription. Dihydrofolate reductase is markedly hyperproduced in strains of Diplococcus pneumoniae which bear any one of a unique group of sense to sense mutations (ame(r)) in the corresponding structural gene. Increased enzyme levels mediated by the ame(r) mutations are apparently the result of increased rates of de novo synthesis. The basis for these effects could be transcriptional, translational or could involve an increase in messenger RNA stability. Data revealing no difference in stability of the related mRNA in a variety of mutants and the wild-type strain appear to eliminate the last possibility. Other data support the idea of an effect on transcription. This includes the extreme sensitivity of ame(r) mutation expression following genetic transformation, to inhibition by actinomycin D and rifampacin, and the presence in one extremely high level mutant (ame(r)-3 with 120 times the wild-type enzyme content) of increased amounts of mRNA. The data are most compatible with the idea of a regulatory function for the dihydrofolate reductase protein in this organism.


Recognition of streptococcal DNA by a mutant pneumococcus unable to discriminate among markers in pneumococcal DNA. A mutant strain of pneumococcus which fails to discriminate against low-efficiency markers during transformation by homospecific pneumococcal donor DNA retains the wild-type capacity to discriminate against heterospecific (streptococcal) donor DNA. We conclude that discrimination against heterospecific DNA must differ from that against low-efficiency markers by the kind or number of elements being recognized.


Studies of biologic and serologic activities of rabbit-IgG antibody depleted of carbohydrate residues.


Restricted rabbit antibodies: amino acid sequences of rabbit H chains of allotype a1, a2, and a3 in the region 80 to 94.


The epileptogenic effects of folate derivatives in the rat.


Combined transpyeloureterostomy and ipsilateral pyeloureterostomy and orchiopexy by testicular artery transection: treatment in a case of prune belly syndrome.


Letter: Treatment of jellyfish stings.

Letter: Treatment of jellyfish stings.


Striatal tyrosine hydroxylases with high and low affinity for tyrosine: implications for the multiple-pool concept of catecholamines.


Secular trends in the prevalence of caries.


Oxidation of S-carboxymethylcysteine by D-aspartate oxidase.


The effects on canine cardiac Purkinje fibers of Chrysaora quinquecirrha (sea nettle) toxin.


Effect of temperature on the mixed function oxidase-catalyzed metabolism of O,O-diethyl p-nitrophenyl phosphorothionate (parathion).


The effect of two jellyfish toxins on calcium ion transport.


Mammalian glutamine synthetase: molecular and regulatory properties.


The fourth A. J. Kluyver memorial lecture delivered before the Netherlands Society for Microbiology on April 27th, 1972, at the Delft University of Technology, Delft. The halobacteria's confusion to biology.


The occurrence of Streptococcus mutans in the dental plaque of a group of Central Australian Aborigines.


The association between dental caries and the availability of sweets in South Australian school canteens.


A theoretical study on the amount of ATP required for synthesis of microbial cell material.


Energy transduction in photosynthetic bacteria. VI. Respiratory sites of energy conservation in membranes from dark-grown cells of Rhodopseudomonas capsulata.


The isolation and characterization of plasma membranes from normal and leukaemic cells of mice.


Cardiospecific beta-adrenergic blockade in the treatment of nervous heart symptoms.


Protective effects of azathioprine and phenobarbital on acute liver damage produced by galactosamine.


Growth patterns of fetal hemopoiesis and the regulation of fetal erythropoiesis.


Friend leukemic mouse stem cell reversion to normal growth in irradiated hosts.


Clinical evaluation of three concentrations of sodium fluoride in dentifrices.


Nurse of feldsher? A crisis of identity.


Adrenergic receptors: a personal and practical view.


A study of traumatized permanent teeth in children 7-15 years. I.


Gamma-glutamyl transpeptidase in diseases of the liver and bone.


Gamma-glutamyl transpeptidase and other liver function tests in myocardial infarction and heart failure.


Acute respiratory infections in different ecologic settings. I. Argentine military recruits.


Nicotinamide nucleotide coenzymes in mycobacteria.


Modification of myocardial infarction size after coronary occlusion.


Ediortial: Isoenzymes of creatine phosphokinase and diagnosis of myocardial infarction.


Corneal erosions in tyrosinosis.

Corneal erosions in tyrosinosis.


Hypertensive effects of prolonged auditory, visual, and motion stimulation.


Experimental studies on overwintering conditions of mosquitoes.


Effects of dietary protein content and glucagon administration on tyrosine metabolism and tyrosine toxicity in the rat.


Effect of perinatal undernutrition on the metabolism of catecholamines in the rat brain.


Metabolism of clindamycin. II. Urinary excretion products of clindamycin in rat and dog.


Rift Valley fever. 2. Attempts to transmit virus with seven species of mosquito.


Pharmacological findings during azidocillin treatment of chest infections.


Septicemia in narcotic addicts.

Septicemia in narcotic addicts.


Broad or narrow spectrum therapy? Studies with ampicillin and azidocillin in acute chest infections.


Editorial: Allied health manpower: the physician's associate.


Cardiovascular haemodynamics during fluroxene anaesthesia in patients with aortic valvular disease.


Cardiovascular haemodynamics during fluroxene anaesthesia in patients with muscular subaortic stenosis.


The glucose effect in rat liver: studies of delta-aminolevulinate synthase and tyrosine aminotransferase.


Activation and blockade of beta adrenoceptors in common cardiac disorders.


Cleavage of lens protein-GSH mixed disulfide by glutathione reductase.


Immunocompetence in regional graft-versus-host reaction of blood cells from skin allografted or ALS treated rats.


The influence of hostsplenectomy on the tumour allograft-promoting effectiveness of antilymphocyte serum.


Serum D-glutamyl transferase following myocardial infarction. D-glutamyl transferase (GMT) activity was measured in 49 patients with proven myocardial infarction. Twenty-three patients had normal GMT activity and 26 had increased GMT activity. Most of the patients with increased GMT had evidence of liver dysfunction and it is suggested that any increases in serum GMT activity following myocardial infarction are a result of secondary liver damage rather than a release of GMT from cardiac tissue.


Enzymes involved in phenylalanine metabolism in the human foetus and child. The activities of phenylalanine p-hydroxylase, tyrosine: alpha-ketoglutarate and phenylalanine: pyruvate aminotransferases, and aromatic alpha-ketoacid reductase have been measured in liver biopsies obtained from children with a series of disorders other than phenylketonuria and from human foetuses aged 8.5 to 24 weeks. The importance of such a study in relation to the management of infants with hyperphenylalaninaemia and pregnant phenylketonuric women is discussed


A comparative study of flight performance and fuel utilization as a function of age in females of Florida mosquitoes.


Current therapy for undescended testicle. Rationale for treatment between ages four and five.


Inflammatory bowel disease in the adolescent patient.


Agglutinins from fish ova defining blood groups B and P.


The effects of centrophenoxine and palmitoylethanolamide on the social behavior of rats malnourished in early postnatal life.


Psychiatric pharmacotherapy and the schizophrenic defect.


Influence of progestational steroids on hypothalamic tyrosine hydroxylase activity in vitro.


The effect of amantadine on neuroleptic-induced parkinsonism.


Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals.


Summary: conference on dibenzodioxins and dibenzofurans, National Institute of Environmental Health Services, April 2-3, 1973.


TCDD-induced changes in rat liver microsomal enzymes.


Integration efficiencies of spontaneous mutant alleles of amiA locus in pneumococcal transformation. The distribution of integration efficiencies of independent mutations spontaneously occurring in the amiA locus was determined in two strains of pneumococcus. Strain Cl(3) integrates genetic markers with different efficiencies during transformation, whereas strain 401, isogenic with strain Cl(3), does not discriminate between markers and integrates all markers with the same high efficiency. The discriminating strain Cl(3) gives rise to spontaneous mutations in the locus amiA, which fall into four classes with respect to their individual integration efficiencies. Mutations with a low efficiency of integration are equal in number to mutations with a high efficiency. Mutations from the two other classes corresponding to intermediate and very high efficiencies are about five times less frequent. The same four classes were also found among amiA mutants spontaneously occurring in strain 401. However, the two distributions of integration efficiencies of amiA mutants arisen either in strain Cl(3) or strain 401 are significantly different. The number of spontaneous amiA mutants, estimated by two methods, was found to be higher in strain 401 than in strain Cl(3). The increase of the mutation rate in strain 401 could be accounted for by the excess of mutations falling in the two less-efficient classes observed in this strain. The discriminating process which acts during transformation presumably also intervenes in the appearance of spontaneous mutations.


Purification and regulation of glucose-6-phosphate dehydrogenase from Bacillus licheniformis. d-Glucose-6-phosphate nicotinamide adenine dinucleotide phosphate (NADP) oxidoreductase (EC 1.1.1.49) from Bacillus licheniformis has been purified approximately 600-fold. The enzyme appears to be constitutive and exhibits activity with either oxidized NAD (NAD(+)) or oxidized NADP (NADP(+)) as electron acceptor. The enzyme has a pH optimum of 9.0 and has an absolute requirement for cations, either monovalent or divalent. The enzyme exhibits a K(m) of approximately 5 muM for NADP(+), 3 mM for NAD(+), and 0.2 mM for glucose-6-phosphate. Reduced NADP (NADPH) is a competitive inhibitor with respect to NADP(+) (K(m) = 10 muM). Phosphoenolpyruvate (K(m) = 1.6 mM), adenosine 5'-triphosphate (K(m) = 0.5 mM), adenosine diphosphate (K(m) = 1.5 mM), and adenosine 5'-monophosphate (K(m) = 3.0 mM) are competitive inhibitors with respect to NAD(+). The molecular weight as estimated from sucrose density centrifugation and molecular sieve chromatography is 1.1 x 10(5). Sodium dodecyl sulfate gel electrophoresis indicates that the enzyme is composed of two similar subunits of approximately 6 x 10(4) molecular weight. The intracellular levels of glucose-6-phosphate, NAD(+), and NADP(+) were measured and found to be approximately 1 mM, 0.9 mM, and 0.2 mM, respectively, during logarithmic growth. From a consideration of the substrate pool sizes and types of inhibitors, we conclude that this single constitutive enzyme may function in two roles in the cell-NADH production for energetics and NADPH production for reductive biosynthesis.


Catabolism of D-gluaric acid to alpha-ketoglutarate in Bacillus megaterium. Crude cell-free extracts of d-glucarate-grown cells of Bacillus megaterium converted d-glucarate to alpha-keto-beta-deoxy-d-glucarate (KDG). Charcoal-treated cell-free extracts or partially purified enzyme preparations converted KDG to an intermediate which was isolated and identified as 2,5-diketoadipate (DKA). This compound was synthesized, and the cell-free extracts of d-glucarate grown cells were found to catalyze the reduction of nicotinamide adenine dinucleotide (NAD) in its presence. In the absence of NAD, the same enzyme preparation catalyzed the decarboxylation of the DKA to alpha-ketoglutarate semialdehyde (KGS), whereas in the presence of NAD the KGS was subsequently oxidized to alpha-ketoglutarate by alpha-ketoglutarate semialdehyde dehydrogenase. Since galactarate-grown B. megaterium contains a galactarate dehydrase forming KDG, the complete pathway for the metabolism of d-glucarate or galactarate to alpha-ketoglutarate and CO(2) is now known in a gram-positive bacterium.


Multiple sites for coupling of glucose transport to the respiratory chain of membrane vesicles from Azotobacter vinelandii.


Inhibition studies of rat citrate synthase.


A glutamyl residue in the active site of triphosphopyridine nucleotide-dependent isocitrate dehydrogenase of pig heart.


Triage, technicians, and teaching in a children's emergency room.


Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.


The effect of abnormal position, scrotal repositioning, and human gonadotropic hormone on the developing puppy testis.


Letter: Hemolytic anemia as adverse reaction to salicylazosulfapyridine.


The stimulation of lipid peroxidation produced by dimethylnitrosamine in rat liver microsomes in vitro: the effects of promethazine and inhibitors of drug metabolism, and a comparison with previous studies using carbon tetrachloride.


Interference of the reduction of p-nitrobenzoate in E. coli by nitrofurantoin.


Chemical respirogenesis: a comparative study.


Effects of beta-blocking agents on atrio-ventricular and intraventricular conduction in man.


Double-blind trial of doxicycline in acute maxillary sinusitis. A clinical and bacteriological study.


Genetic classification and biological properties of temperature-sensitive mutants of fowl plague virus.


Study on the mutagenic action of O-methylhydroxylamine on RNA viruses (on the model of fowl plague virus).


Investigations on the dynamics of the reaction between tick-borne encephalitis virus and its specific receptor substance.


Behaviour of attenuated mutants of the A0-NWS influenza virus in mice after intracerebral inoculation. I. Induction of resistance to challenge with neurotropic A0-NWS virus.


Serum immunoglobulins in white rats immunized with foot-and-mouth disease virus antigens.


Rickettsial toxin and its specificity in 3 prototype strains, Karp, Gilliam and Kato, of Rickettsia orientalis.


Analysis of Sindbis virus and its soluble antigens in preparations concentrated by precipitation with polyethylene glycol or ammonium sulfate.


Interferon production and infection caused by influenza virus in radiation chimeras.


Multiplication of parainfluenza type 1 virus in chick embryos.


Blackbird, Turdus merula L., and tick-borne encephalitis (TBE) virus.


DNA composition in Rickettsia mooseri by base analysis.


Olkya--an arbovirus of the Bunyamwera group in the U.S.S.R.


In vitro evidence for a cell-mediated component of the immune response in mice given the highly attenuated E5 "14" Langat virus (the tick-borne encephalitis complex).


The use of receptor destroying enzyme for removing non-specific serum inhibitors against recent influenza virus strains.


View of human problems to be addressed for long-duration space flights.


12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one by a reconstituted system from rat liver microsomes.


Cross-linking of salmon fibrinogen and fibrin by factor XIII and transglutaminase.


Activity of horse liver alcohol dehydrogenase SS with NADP (H) as coenzyme and its sensitivity to barbiturates.


The use of the oxidant"diamide" for studying the non-mitochondrial reducing capacity of Ehrlich ascites tumor cells.


Fluorescent labeling of proteins. A new methodology.


Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.


Editorial: World Medical Association.

Editorial: World Medical Association.


Biochemical effects of oxygen at high pressure in rats.


Histochemical localization of delta 5-3 beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase in the testis of Indian skipper frog Rana cyanophlyctis (Schneider).


A neurohormone of cephalopods with cardioexcitatory activity.


Anti-inflammatory drug mechanisms.

Anti-inflammatory drug mechanisms.


Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver.


Adrenergic antagonists, and a possible link between the increase in cyclic adenosine 3',5'-monophosphate and DNA synthesis during liver regeneration.


Pyridine nucleotide metabolism in mammalian cells in culture.


Effect of gonadotropins in the induction of spermatogenesis in human prepubertal testis.


Use of LB-46, a new anti-arrhythmic agent, during anesthesia.


The influence of ethanol administered to pregnant rats on tyrosine hydroxylase activity of their offspring.


Inhibition of graft-versus-host reaction by preincubation of the graft with a thymic extract (lymphocyte chalone).


The impairment of graft-versus-host reaction by immunisation of F1 hybrids with low doses of parental cells.


The graft-versus-host reaction in the snapping turtle Chelydra serpentina.


Hyposplenism and pneumococcemia. Visualization of Diplococcus pneumoniae in the peripheral blood smear.


Fluorescence and phosphorescence of antihistamines having the 2-aminopyridine chromophore. Effect of pH on fluorescence.


Control of the microsomal mixed-function oxidase by Ox2 and Ox5 genes in houseflies.


Metabolic properties of erythrocytes of normal and genetically anemic mice.


Adaptation of the tiger salamander, Ambystoma tigrinum, to arid habitats.


Pharmacological prevention of acute ventilatory capacity reduction in flax dust exposure.


Role of alkaline phosphatase in intestinal water absorption by eels adapted to sea water.


Effects of hypophysectomy and environmental salts on intestinal alkaline phosphatase of the eel in relation to sea water adaptation.


Ventilation in two species of lizards during rest and activity.


The structure, composition and elastic properties of the teleost bulbus arteriosus in the carp, Cyprinus carpio.


Blood physiology and oxygen transport during activity in two lizards, Varanus gouldii and Sauromalus hispidus.


Effects of acclimation on oxygen consumption (QO2) of the brain and its different areas in two genera of anurans.


Induction of bioluminescence in a luciferin deficient form of the marine teleost, Porichthys, in response to exogenous luciferin.


Water intake and activity of rodents and Leiothrix lutea under continuous light.


Cardiac and respiratory responses of rainbow trout, bluegills and brown bullhead catfish during rapid hypoxia and recovery under normoxic conditions.


Heat measurements associated with isometric contraction in fast and slow muscles of the chicken.


Panting thresholds of lizards. II. Diel variation in the panting threshold of Amphibolurus muricatus.


Panting thresholds of lizards. I. Some methodological and internal influences on the panting threshold of an agamid, Amphibolurus muricatus.


Erratum: Relaxation of catch in a molluscan smooth muscle. II. Effects of serotonin, dopamine and related compounds.


Effects of ethidium bromide on various segments of the respiratory chain in the cellular slime mold, Dictyostelium discoideum.


Animal models for biomedical research. V. Invertebrates. Introduction.


Phylogeny of immune responsiveness: marine invertebrates.


Basic principles in the use of antipsychotic agents.


Editorials: malpractice in the 14th century.


EKG of the month.

EKG of the month.


Radiologist Francis E. Bihss, M.D., honored.


Gastric leiomyoma.

Gastric leiomyoma.


The Haight-Ashbury drug-using subculture and the MMPI psychopathic scale.


The presence and the influence of germination on the gamma-aminobutyrate pathway in Lupinus albus seeds.


Population variation among alcoholism treatment facilities.


Granulomatous aortitis associated with necrotizing angiitis and glomerulonephritis.


Halothane-induced lipolysis in rats.

Halothane-induced lipolysis in rats.


Studies on cytoplasmic membrane fractions from guinea pig pancreas.


Subcellular localization of neurotransmitters.


Subcellular organization of the median eminence.


Effect of drugs on adrenergic nerve terminals.


Structure-function relationships in inhibitory synapses.


Cellular and molecular aspects of transmitter release: calcium monoamine dynamics.


A role for the pyridine nitrogen of reduced triphosphopyridinenucleotide in an enzymatic catalysis.


On the interaction of para-hydroxybenzoate hydroxylase from Pseudomonas fluorescens with halogen ions.


Test-taking sets and the performance of schizophrenics on laboratory tests.


The glucose dehydrogenase activity of the NAD-linked glucose-6-phosphate dehydrogenase from Acetobacter xylinum.


Extraction from bovine spleen of immunosuppressant with no activity on hematopoietic spleen colony formation.


Editorial: Leprosy vectors.

Editorial: Leprosy vectors.


Temperature optima of neuraminidase activity of influenza viruses.


Study on the mechanism of inhibiting action of aminoadamantane on the reproduction of fowl plague virus.


Development of antibodies to neuraminidase of A2-Hong Kong and A2-Taiwan influenza viruses after administration of different Hong Kong vaccines and after natural infection in humans.


Experimental studies on influenza A2 virus infection after peroral inoculation.


Resistance of mice immunized per os with A2 influenza virus to intranasal challenge with a pathogenic strain.


Cultivation of ganglia on monofil fabric, a suitable method for demonstration of latent herpesvirus infection.


Use of proflavine-sensitized poliovirus strains for determination of the range of susceptible animals.


Formation of autoantibodies in laboratory animals after inoculation of viruses with different virulence. I. Results of studies on vaccine and wild strains of polio and measles viruses in guinea pigs.


Viral infection and resistance in immunosuppressed host. IV. Abolition of potentiated togavirus A infection by a resistance inducer of the double-stranded RNA type. Failure of an exogenous interferon preparation.


Transmission of Kyasanur Forest disease virus by the soft tick, Ornithodoros crossi.


Studies on antigenic peculiarities of West Nile virus strains isolated in the U.S.S.R. by three serological tests.


Investigations on rhinovirus inactivation by hydrogen peroxide.


Isolation of Sindbis virus from the reed warbler (Acrocephalus scirpaceus) in Slovakia.


Effect of protein synthesis inhibitors on the replication of virus-induced RNA in Sendai virus-infected cells.


Role of the temperature of incubation of infected chick embryos in the differentiation of certain poxviruses according to pock morphology.


Isolations of coxsackie viruses from Danube river water.


Sequential fluorescent antibody staining for the demonstration of double infection with tick-borne encephalitis and herpes simplex viruses in chick embryo cell cultures.


Changes in some genetic markers of measles virus strain L-16 in the course of passaging in various cell cultures.


Studies on the mutagenic action of proflavine on type 3 poliovirus.


Humoral antibody response in volunteers given the live, highly attenuated "14" clone derived from Langat E5 virus.


HUD's role in the interagency action in nutrition and aging.


Phases of psychopathology after assassination.


Letter: Marijuana flashbacks.

Letter: Marijuana flashbacks.


The histochemistry of prefascial lymph vessels in recurrent erysipelas.


Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines.


Transcriptional and translational control of the biphasic increase in ornithine decarboxylase activity in liver.


On the role of superoxide in reactions catalyzed by rubredoxin of Pseudomonas oleovorans.


The temperature dependence of oxidative phosphorylation and of the activity of various enzyme systems in liver mitochondria from cold- and warm-blooded animals.


Development of host plasma cells during graft-versus-host reactions in mice.


Density gradient separation of chicken thymus cells.


Studies on immunological paralysis. XI. A comparison of the tolerogenicity in vitro of levan and type 3 pneumococcal polysaccharide.


The many facets of cardiac pathology.

The many facets of cardiac pathology.


D-aspartate oxidase in mammalian brain and choroid plexus.


Tyrosine hydroxylase of sheep brain: some catalytic and chemical properties of the detergent-solubilized, partially purified enzyme.


The effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain.


Partial purification and characterization of NADPH-linked aldehyde reductase from monkey brain.


Early changes in respiration, aerobic glycolysis and cellular NAD(P)H in slices of rat cerebral cortex exposed to elevated concentrations of potassium.


Influence of potassium on the steady-state redox potential of the electron transport chain in slices of rat cerebral cortex and the effect of ouabain.


On the association of non-specific esterase activity with central nerve myelin preparations.


Partial purification of a toxin from tentacles of the sea anemone Anemonia sulcata.


An in vivo test for the immunocompetence of human lymphocytes.


Specific inactivation of cytotoxic lymphocytes after adsorption on 51Cr-labeled fibroblast monolayers.


Non-random frequency distributions of caries attacks among mesial and distal surfaces of human permanent mandibular incisors.


The estimation of examiner error and the true transition probabilities for teeth or surfaces in dental clinical trials.


Editorial: Intermediate coronary syndrome.


The fear of heights among alcoholics.

The fear of heights among alcoholics.


Detailed studies on the in vitro antimicrobial activity of antazoline hydrochloride.


II. Medical treatment of inflammatory bowel disease.


A rapid screening procedure for drug and alcohol analysis in serum.


Metabolic, ultrastructural, and mechanical changes in the isolated rat heart perfused with aerobic medium in the absence or presence of glucose.


Enzyme changes in experimental biliary obstruction.


3. Physical characteristics of Yemenite and Kurdish Jews in Israel.


IV. Spirometric studies of Yemenite and Kurdish Jews in Israel.


VI. Energy expenditure and climatic exposure of Yemenite and Kurdish Jews in Israel.


VII. The physical working capacity of Yemenite and Kurdish Jews in Israel.


8. A study of temperature regulation in Yemenite and Kurdish Jews in Israel.


V. Food intake of Yemenite and Kurdish Jews in Israel.


X. Haemoglobin studies of Yemenite and Kurdish Jews in Israel.


IX. The hereditary blood factors of the Yemenite and Kurdish Jews.


XI. The hereditary blood factors of the Kurds of Iran.


XII. Genetic studies in Jordan.

XII. Genetic studies in Jordan.


Biological studies of Yemenite and Kurdish Jews in Israel and other groups in southwest Asia. I. Introduction, background and methods.


Biological studies of Yemenite and Kurdish Jews in Israel and other groups in southwest Asia. 18. Conclusions and summary.


II. A clinical survey of Yemenite and Kurdish Jews in Israel.


A note to identify a certain isolate of Lagenidium which kills mosquito larvae.


Non-nicotinic transmission during ganglionic block with chlorisondamine and nicotine.


The determination of D- and L-14C-amino acids in the presence of their metabolites.


NAD and NADP l-glutamate dehydrogenase activity and ammonium regulation in Aspergillus nidulans.


The distribution of NAD-independent lactic dehydrogenases amongst micro-organisms.


Salt losing nephritis in the prune belly syndrome.


The health care scene: nursing's dilemma.


A history of water fluoridation. Dental caries prevalence in artificially fluoridated areas.


Central depressant effects of the extracts of magnolia cortex.


Lasting effects of early nutrition.

Lasting effects of early nutrition.


Surgical grand rounds: Thymoma with myasthenia.


The changing face of health care delivery.


Neighborhood health centers and model cities. Adjust your practice to their needs? The health care of model cities.


The changing face of health care delivery. Neighborhood health centers and model cities. Adjust your practice to their needs?


15 HMO's in Illinois. How will they affect your practice? The Carbondale "experiment".


The changing face of health care delivery. Fifteen HMO's in Illinois. How will they affect your practice? Intergroup: prepaid health services plan.


Group practice in Lincoln and a HMO.

Group practice in Lincoln and a HMO.


New hope for over-worked doctors and medically deprived areas. General medical services LTD. Physicians-on-call.


The renaissance of the house call.

The renaissance of the house call.


Contract emergency service system.

Contract emergency service system.


The gas chromatographic determination of anticonvulsant drugs in serum.


The changing face of health care delivery. Comprehensive Medical Associates.


Status report: Illinois statewide trauma care system.


Heart to head circulation time.

Heart to head circulation time.


Members of the 1972 House of Delegates.

Members of the 1972 House of Delegates.


Editorial: The treatment of gonorrhea in the female.


Follow it up. The unpaid bill.

Follow it up. The unpaid bill.


Surgical grand rounds: Adrenal cyst.

Surgical grand rounds: Adrenal cyst.


L. T. Fruin, M.D.--in memorian.

L. T. Fruin, M.D.--in memorian.


The management of penetrating wounds of the abdomen with simultaneous bowel and vascular injuries.


Editorial: "Turf" and Illinois' new medical schools.


Ulcerative colitis. Selected clinical, diagnostic and therapeutic aspects.


Surgical grand rounds: Ectopic pregnancy.


Choosing the safest ski binding.

Choosing the safest ski binding.


Maternal death study. Case report no. 1. The first in a series of case reports.


What "health care crisis"?

What "health care crisis"?


The value of the investment counselor.

The value of the investment counselor.


Comparative study of myfadol and meperidine as postoperative analgesics.


Surgical grand rounds: Pancreatic transplantation.


Measles in previously vaccinated children in Illinois.


Management of abdominal trauma in children.


Maternal death study. Case report no. 2. The second in a series of case reports.


Report of a case. Retroperitoneal and gluteal cystic lymphangioma.


Prenatal hormones and human behavior.

Prenatal hormones and human behavior.


Car restraint devices designed for children.


Letter: ISMS where do you stand on abortion?


Editorial: Sudden death--premonition of things to come.


Will your records satisfy the "tax man"?


He who stands and waits.

He who stands and waits.


Earlier and better eye care for children.


Skin manifestations of hypovitaminosis A.


Bicycle spoke injuries. A report of 64 cases.


Surgical grand rounds: resection of myocardial infarct.


Maternal death study. Case report no. 3. The third in a series of case reports.


Chicago Symphony Orchestra--touring Europe.


Initial care of critically injured.

Initial care of critically injured.


Editorial: AHA competes with AMA in health care.


Autos to lease or not to lease.

Autos to lease or not to lease.


Hypothyroidism.

Hypothyroidism.


Autopsy ruling threatens progressive medicine.


Controlling allergic parotitis from foods.


Fluid therapy in hemorrhagic shock.

Fluid therapy in hemorrhagic shock.


Sexual pressures in the society.

Sexual pressures in the society.


Surgical grand rounds: Submaxillary gland cylindroma.


Autotransplantation of splenic tissue. Report of a case.


Maternal death study. Case report no. 4. The fourth in a series of case reports.


"How to fire an aide gracefully".

"How to fire an aide gracefully".


Letter: Treatment of hypertension with drugs can be dangerous.


Changes in nitroglycerin tablet packaging and labeling.


Report suspected child abuse.

Report suspected child abuse.


Electron transfer mechanism involved in stearoyl-coenzyme A desaturation by particulate fraction of Mycobacterium phlei.


A study of the equilibrium between the monomer and the dimer of D-amino-acid oxidase.


Structural abnormalities in the undescended testis.


Effect of penicillamine (a vitamin B6 antagonist) on pyridoxal enzymes.


Torsion of an intraabdominal testicle in a neonate.


Enhancement of Ca-contractions by catecholamines and temperature dependency in the depolarized teania coli of the guinea-pig.


Analysis of mode of action of some nicotinic blocking drugs.


Pharmacology of dl-5-methyl-8-(2-hydroxy-3-t-butylaminopropoxy) coumarin hydrochloride (CS-359), a new beta-adrenergic blocking agent.


The possible role of adenosine triphosphate in chemical transmission between the hypogastric nerve terminal and seminal vesicle in the guinea-pig.


Adrenergic receptors in rat liver. I. Effects of epinephrine and adrenergic blocking agents on gluconeogenesis in perfused liver.


Electrophysiological evidence of the initiation of arrhythmia by beta-adrenergic blocking agents.


Quantitative studies of adrenoceptors in guinea-pig gallbladders.


Automatic refraction: how it is done: some clinical results.


Why do sputum cultures fail to yield pathogens?


The Noonan syndrome--a review of the clinical and genetic features of 27 cases.


Presence of glutamate synthase in fission yeasts and its possible role in ammonia assimilation.


Histochemical changes in developing mouse liver after administration of phenobarbital.


Evolving concepts of the genetics of thyroid disease-a review.


Comparison of centrally mediated hypotensive action of methyldopa and DOPA in cats.


The effects of isoproterenol, isoetharine and butyletharine on beta receptors.


Influence of propranolol on the vascular effects of cadmium and isoproterenol in rabbit aorta.


Factors determining activity and selectivity of antifibrillatory agents on different types of fibrillation.


Case history number 75: hepatic damage after fluroxene anesthesia.


Bone marrow transplantation-clinical results and problems.


20Alpha-hydroxysteroid dehydrogenase of cultured mammalian (HeLa S3) cells.


Some cardiovascular effects of timolol a new beta-adrenergic blocking agent.


Effect of some beta adrenoceptor blocking agents on skeletal neuromuscular transmission and motor co-ordination.


Proceedings: Testicular tumors. Epidemiologic, etiologic, and pathologic features.


Effect of beta-adrenoceptor antagonists on acetylcholine concentration of mouse brain.


Susceptibility of recently isolated pathogenic bacteria to trimethoprim and sulfamethoxazole separately and combined.


Trimethoprim-sulfamethoxazole in the treatment and prevention of purulent exacerbations of chronic bronchitis.


Synthesis of pivaloyloxymethyl 6-N'-cyanoamidinopenicillanates and the antibacterial activity of the corresponding acids.


Trimethoprim-sulfamethoxazole compared with ampicillin in acute infectious exacerbations of chronic bronchitis: a double-blind, crossover study.


Monofluoromethanesulfonanilides. A new series of bronchodilators.


Aromatic amino acid hydroxylase inhibitors. 3. In vitro inhibition by azadopamine analogs.


Adrenergic agents. 1. Synthesis and potential beta-adrenergic agonist activity of some catecholamine analogs bearing a substituted amino functionality in the meta position.


Monoamine neurotransmitters and the pathophysiology of stroke and central nervous system trauma.


Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells.


Spectrophotometric determination of microgram quantities of acetylsalicylic anhydride in acetylsalicylic acid.


Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms.


Imipramine and its metabolites in human brain.


The inhibition of histamine formation in vivo.


Lesions in the septal nuclei of the rat raise mean systemic arterial pressure and prevent the development of sound-withdrawal hypertension.


The evaluation of the alpha-adrenoceptor blocking action of indoramin, phentolamine and thymoxamine on the rat and guinea-pig isolated mesenteric vasculature and aortic spiral preparations.


The alpha-adrenoceptor blocking effect of indoramin on human isolated smooth muscle.


The formulation and sterilization of a surgical lubricant gel based on carboxypolymethylene.


Influence of electrolytes on the hydration of methylcellulose in solution.


Letter: Effects of 5,6-dihydroxytryptamine on the metabolism of 5-hydroxytryptamine in the central nervous system of the rat.


Catalepsy and stereotyped behaviour in rats treated chronically with methadone: relation to brain homovanillic acid content.


Letter: Comparison of the blocking effects of antagonists of adrenaline and 5-hydroxytryptamine on their mutual receptors.


Letter: Arachidonic acid lowers and indomethacin increases the blood pressure of the rabbit.


Letter: Lack of influence of indomethacin on neurogenic vasodilatation in the hind-limb and spleen of the dog.


Letter: Some factors modifying the metabolism of AH 8165 by rat liver homogenate in vitro.


Letter: Effect of 3,4-dimethoxyphenethylamine on monoamine-depleted rats.


Letter: Salbutamol: agonistic and antagonistic activity at beta--adrenoceptor sites.


Letter: Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents.


Letter: Effects of antiparkinsonian drugs on neuroleptic-induced extrapyramidal signs in monkeys.


Letter: Effect of various steroids and ACTH on methyprylon plasma levels and sleeping time in rats.


Letter: Lipolysis induced by coffee and tobacco: its modification by insulin.


Letter: Dithiocarbamate central effects in relation to their possible influence on drug metabolizing enzymes.


Letter: A note on the analysis of disodium cromoglycate (Intal) in human urine.


Letter: The transport number of noradrenaline as a function of pH.


Letter: The crystallization of sulphadiazine by the solvent change method in turbulent conditions.


Metabolism and anticonvulsant activity of deuterated N-demethyldiazepam.


Alkylation reactions of hydantoins and succinimides.


Polyarteritis nodosa in infancy: a diagnostic enigma.


Pneumonia in New Guinea. I. Bacteriological findings in 632 adults with particular reference to haemophilus influenzae.


Pneumonia in new guinea. II. Pneumococcal serotypes and the possible utility of polyvalent vaccines of capsular polysaccharides.


Environmental dermatitis: patch tests in 1,000 cases of allergic contact dermatitis.


Reactivity of lymphoid cells from mice humorally tolerant to histocompatibility antigens.


Effects of a beta-adrenergic agent (metaproterenol) on uteroplacental circulation. An angiographic study in the pregnant rhesus monkey.


The placenta: immunologic or hemodynamic protector of the fetus?


Editorial: New vasodilator drugs for hypertension.


Myopathy associated with anticonvulsant osteomalacia.


Diseases of the skin. Management of eczema. II.


Letter: Suicidal attempts with beta-adrenoceptor blocking agents.


Diseases of the skin. The management of pruritus.


Proceedings: A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (salazopyrin).


Faith healing. A study of personality and function.


The use of LSD in time-limited psychotherapy.


Psychological studies of longer range L-DOPA therapy in Parkinsonism.


C-reactive protein-like precipitins in plaice.


Inhibition of local graft-versus-host reaction by anti-alloantibodies.


Localisation of glutamine synthetase in chloroplasts.


Effects of membrane stabilizers on glucuronidation and amino acid transport in cultures of rat hepatoma cells.


Partial tolerance and immunity after adoptive abrogation of transplantation tolerance in the rat.


A familial incidence of structurally restricted antibodies to pneumococcal polysaccharides.


Rapid multichannel microfluorometry for metabolic and spectral studies in single living cells.


Acquisition of an embryonal biochemical feature in the rat liver after portacaval shunt.


Beta-sympatholytics as non-specific inhibitors of serum cholin-esterase.


Visualization of immunoadsorption by immunofluorescence.


An evidence for the presence of beta-receptors in the seminal vesicle of guinea-pig.


Hepatic and metabolic effects of alcohol (1966 to 1973).


Physician's assistants for Minnesota family practitioners.


Aequorin luminescence during contraction of amphibian skeletal muscle.


Migraine treated with an antihistamine-analgesic combination.


Oral and dental state in Helsinki preschool children. IV. Caries incidence in the deciduous dentition.


Comparative in vitro study concerning the effects of thrombin and serotonin on the platelet energy transferring system.


Value of percutaneous transhepatic cholangiography in "institutional jaundice".


Failure to thrive, vomiting, and undescended testes in a two-month-old boy.


Mesenteric angiographic studies in children with regional enteritis.


The role of cyclic 3',5'-adenosine monophosphate in neuromuscular transmission.


Antibronchoconstrictor activity of two new phosphodiesterase inhibitors, a triazolopyrazine (ICI 58 301) and a triazolopyrimidine (ICI 63 197).


Factors affecting the antidiuretic actions of the 18-monoacetate of (+)-aldosterone and of a substance secreted by eart muscle, in rats.


A note on the effect of amantadine on body temperature in mice.


Further observations on the experimental antidysrhythmic activity of indoramin hydrochloride.


Metabolism of amphetamines. Identification of N-oxygenated products by gas chromatography and mass spectrometry.


A quantitative approach to the in vitro availability of drugs from some non-ionic surfactant solutions.


The determination of fluorochlorocarbons in air and body fluids.


The packing properties of moist bulk solids.


Some properties of an oil-soluble phosphated fatty alcohol ethoxylate.


The interaction of Escherichia coli and magnesium trisilicate in aqueous suspension.


Letter: The effect of local anaesthetics on the incorporation of 32P into the phosphoinositides of rabbit vagus nerve.


Letter: Prostaglandins as regulators of bradykinin responses.


Letter: Preliminary investigation of the metabolism of piribedil (ET 495); a new central dopaminergic agonist and potential anti-parkinson agent.


Letter: The activation of pineal hydroxyindole-O-methyltransferase by psychotomimetic drugs.


Letter: The influence of halothane on calcium uptake by isolated cell membranes.


Letter: The action of anti-inflammatory drugs in two models of inflammation.


Letter: Amphetamine-induced inhibition of tyrosine hydroxylation in homogenates of rat corpus striatum.


Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration.


Letter: Reduction of audiogenic seizure by delta8- and delta9- tetrahydrocannabinols.


Letter: The fluorescence of paracetamol--a re-examination.


Letter: The influence of tablet weight on compaction pressure-tablet density relations.


Production by stimulated macrophages of factors depressing lymphocyte transformation.


Proceedings: Medical aspects of ulcerative colitis in childhood.


Proceedings: A new steroid anaesthetic-althesin.


Infarction of an abdominal undescended testis presenting as a calcified abdominal mass in a newborn.


Chemotherapy in chronic organic brain syndrome--a review of the literature.


Reconstruction of the plantar pad after degloving injuries of the foot.


Posterior para-urethral diverticulum. Case report.


Where we stand.

Where we stand. To serve the interests of members and to function in the public interest, the California Medical Association must set policies and take positions on current issues affecting the health care of Californians. These policies then guide the activities of the Association in fulfilling its leadership role and its responsibility to the public.Delegates, elected by the membership of CMA's component medical societies, meet annually to deliberate and determine the policies and courses of action for the Association. Between meetings of these Delegates, the CMA Councilors, elected by their district membership, implement the directives of the Delegates and set interim policies. By this democratic process, the membership governs the CMA. Association members must be informed if they are to participate effectively in the affairs of their medical organizations. To disseminate better understanding of CMA's activities, position papers on current issues have been developed. They are based on House of Delegates resolutions and Council actions. Entitled "Where We Stand on Medical and Health Issues," these papers represent the current policy positions of CMA. Each paper is annotated to give the reference source of the policy actions. As with any organization, CMA policies are subject to timely revision. When policies are amended or new policies are adopted, new papers will be developed.


Mackay-Marg tonometry by technicians.

Mackay-Marg tonometry by technicians.


The physician's associate-a task analysis.


Echocardiographic assessment of idiopathic hypertrophic subaortic stenosis.


Studies on sweating in clinical and experimental thyrotoxicosis.


An oxidative analytical procedure for some compounds containing the diphenylmethylidene group.


Athletic injuries.

Athletic injuries.


Induction of adrenal catecholamine synthesising enzymes following mother-infant separation.


Tooth decay.

Tooth decay.


Effect of blockade of the alpha-adrenergic receptors on insulin response to glucose infusion in prediabetic subjects.


In vitro biosynthesis of androgens in canine testes.


Beta-adrenergic effects on rat myometrium: mechanisms of membrane hyperpolarization.


Adenyl and guanyl cyclase in rabbit gastric mucosa.


The effect of certain drugs on the plasma protein binding of phenytoin.


Complement metabolism in rheumatoid arthritis. I. Longitudinal studies.


Dynamic synaptic communication: finding the vocabulary.


Functional properties of the purified cholinergic receptor protein from Electrophorus electricus.


Aminergic transmission. Introduction and short review.


Reduction in GADI activity from the dorsal lateral region of the deafferented rat spinal cord.


Effect of sodium, hemicholinium-3 and antiparkinson drugs on (14C)acetylcholine synthesis and (3H)choline uptake in rat striatal synaptosomes.


Immunological studies of runting syndrome in rats inoculated with Friend virus.


Serum luteinizing hormone and follicle stimulating hormone in normal children and patients with various clinical disorders.


Electrophoretic investigation of some red cell enzymes in Iran.


The secretion and development of nematocysts in a siphonophore.


MAG spokesman defends Georgia physicians.


Developmental inhibition of mosquitoes and the house fly by urea analogues.


Laboratory transmission of Wisconsin isolates of a Cache Valley-like virus by mosquitoes.


Adaptation of two mosquito cell lines to medium free of calf serum.


Anaerobic infection of the paranasal sinuses.


Oral and dental state in Helsinki preschool children. II. Caries in early erupting permanent teeth.


The fine structure of the PD proprioceptor of Cancer pagurus. I. The receptor stand and the movement sensitive cells.


The water metabolism of a small East African antelope: the dik-dik.


The fine structure of the PD proprioceptor of Cancer pagurus. II. The position sensitive cells.


Molecular alterations in the plasma membrane of sporangiospores of Phycomyces related to germination.


The effect of atropine on acetylcholine action at the neuromuscular junction.


Some comments about the personality comparison of incarcerated and street heroin addicts.


Indications of psychopathology in applicants to a county methadone maintenance program.


Demographic and MMPI characteristics of male and female state hospital alcoholic patients.


Seasonal variation of personality of college students as measured by the MMPI.


Evaluating a dental caries preventive programme.


Morphine lethality in rats: effects of inhibitors of brain catecholamine synthesis and methylation.


Attempts at treatment of intracranial arterial spasm in animals and human beings.


Massive lethal hepatic necrosis in rats anesthetized with fluroxene, after microsomal enzyme induction.


Dexetimide: an effective drug for the control of extrapyramidal symptoms induced by pipothiazine palmitate.


Metabolism of vasoactive hormones by lung.


3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni.


The substrate analog bromopyruvate as a substrate, an inhibitor and an alkylating agent of malic enzyme of pigeon liver.


Specific H-bonding of glutarimides and hydantoins to derivatives of RNA bases in chloroform solution.


The doctor and the pharmaceutical industry.


Adjustment of welfare recipients and applicants: investigation of some relevant factors.


Pyogenic meningitis in infants and children. A clinical and bacteriologic study.


Biohydrogenation accompanying the beta-oxidation of unsaturated fatty acids by Candida.


The properties of trehalase from the mosquito-parasitizing water mold, Lagenidum sp.


An approach to laboratory evaluation.

An approach to laboratory evaluation.


Changes in enzyme activities of rat liver peroxisomes under various physiological conditions.


Involvement: form the classroom to the community.


Conceptual models as guides to clinical nursing specialization.


The development and use of level objectives in a diploma program.


Orientation to the psychiatric nursing experience.


Students' experiences with the prenatal care of high-risk pregnant women.


The surgeon's assistant's education and role.


The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.


The effect of dietary protein and fat on the activity of aryl hydrocarbon hydroxylase in rat liver, kidney and lung.


Effects of acute and chronic administration of desmethylimipramine on the content of norepinephrine and other monoamines in the rat brain.


Health sciences curricula: public health microbiology and medical laboratory technology.


The message of combined epidemiological and laboratory investigations into the caries condition of Polynesians.


Personality characteristics of male native American alcoholic patients.


Slaframine (slobber factor) toxicosis.

Slaframine (slobber factor) toxicosis.


Physiology of the eye pertinent to anesthesia.


Regulation of tyrosine hydroxylase activity in mouse neuroblastoma clone N1E-115.


Further studies on the mitochondrial changes during the life cycle of Plasmodium berghei: electrophoretic studies on isocitrate dehydrogenases.


Letter: Adrenergic-blocking drugs in hyperthyroidism.


Citric acid cycle activity and chloroquine resistance in rodent malaria parasites: the role of the reticulocyte.


Nocturnal penile tumescence and sleep of convicted rapists and other prisoners.


Light-induced oxidation-reduction reactions in a cell-free preparation from the blue-green alga Nostoc muscorum: the role of cytochrome f, cytochrome b558, C550, and P700 in noncyclic electron transport.


The oxidoreduction state of free NAD(P) and mass-action ratio of total nicotinamide nucleotides in isolated rat-liver mitochondria.


Crisis theory: a definitional study.

Crisis theory: a definitional study.


Hepatic function tests.

Hepatic function tests.


Beta-adrenergic blockade and plasma renin activity in borderline hypertension.


In vitro activity of diethylcarbamazine on the infective larvae, microfilariae and adult worms of Breinlia sergenti.


Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures. Immunoglobulin concentrations were studied in 255 specimens of middle ear fluid (MEF) from 165 episodes of acute otitis media in children. There were significant amounts of all three major immunoglobulins (Ig) in MEF, the mean concentration of IgA being 39 mg/100 ml, of IgM 63 mg/100 ml, and of IgG 383 mg/100 ml. Secretory component was present in all 10 MEF specimens in which it was sought. In patients over 9 months of age, there was a decreased likelihood of isolating pathogenic bacteria from MEF if the patient had higher concentrations of IgA in MEF than in simultaneously obtained serum. IgA concentrations were greater in MEF than in serum in almost half the patients, and the mean MEF-serum ratio for IgA was 1.38. Thus, it would appear that in this disorder MEF represents primarily a secretory response to inflammation rather than a transudate.


Effect of histamine and its methyl derivatives on cyclic AMP metabolism in gastric mucosa and its blockade by an H2 receptor antagonist. In a cell-free system prepared from guinea pig gastric mucosa, histamine and Nalpha-methyl-histamine produced dose-dependent stimulation of cyclic AMP formation and 1,4-methylhistamine had a minimal stimulatory effect. N-methyl-N'-(2-[5-methylimidazole-4-yl-methylthio]-ethyl) -thiourea (metiamide), a new H2 receptor inhibitor, selectively blocked the stimulation of adenylate cyclase by histamine and its active methyl derivative but had no substantial effect on the basal adenylate cyclase activity or adenylate cyclase stimulated by sodium fluoride. Metiamide inhibited the histamine stimulation of adenylate cyclase at 1/100 the concentration of the histamine. Histamine, its methyl derivatives, and metiamide did not influence the activity of cyclic AMP phosphodiesterase from gastric mucosa. Therefore, histamine stimulates gastric mucosal adenylate cyclase via interaction with the H2 receptor without influencing cyclic AMP breakdown, and N-methylation of histamine on the side chain preserves or even increases its stimulating ability. On the other hand, N-methylation in the ring nearly abolishes the ability of histamine to interact with the H2 receptor.


National health policy: objectives and strategy.


Cytochemical examination of the effect of histamine on adenylate cyclase activity in guinea pig heart tissue.


GLC analysis of metapyrilene in plasma and urine using a sulfur-specific flame-photometric detector.


Soldering porcelain-fused-to-metal fixed partial dentures.


Hereditary angioneurotic oedema.

Hereditary angioneurotic oedema.


Experimental osteogenesis with decalcified allogeneic bone matrix in palatal defects.


Central nervous system and autonomic nervous system effects of amantadine and of some standard anti-Parkinson drugs.


Effect of clonazepam (Ro 5-4023) on epileptic seizures.


Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports.


Etiologies and characteristic features of pneumonias in a municipal hospital.


Incorporation of radioactive acetate into diacetyl by Streptococcus diacetilactis. Streptococcus diacetilactis was grown in a partially defined, lipoic acid-free medium containing radioactive acetate with and without addition of 0.1% unlabeled sodium pyruvate. Labeled carbon was incorporated into diacetyl, but neither the amount of diacetyl produced nor its specific activity was influenced by addition of pyruvate. Acetoin had low specific activity, indicating that it was a mixture of radioactive and nonradioactive acetoin. The specific activity of acetoin was lower when pyruvate, a precursor of unlabeled acetoin, was added to the medium, which indicated that the radioactive acetoin was produced from radioactive diacetyl by diacetyl reductase. Results substantiate condensation of acetyl-coenzyme A with hydroxyethylthiamine pyrophosphate as the in vivo mechanism for synthesis of diacetyl.


Mechanism and biosynthetic requirements for F plasmid replication in Escherichia coli.


A lipotrope-dependent increase of histidase and urocanase in the livers of choline-deficient rats and in the Reuber H-35 transplanted hepatoma.


The effect of some biphenyl solubilizing and suspending agents on biphenyl 4-hydroxylase of rabbit liver microsomes.


Graft-vs.-host reaction in tissue culture. The primary purpose of this study has been to validate the in vitro graft-vs.-host reaction as an experimental system. Time-dose studies have been presented for cells obtained from spleen, thymus, cortisone-treated thymus, inguinal lymph node, mesenteric lymph node, thoracic duct, and bone marrow cells. Both the degree of splenomegaly and the onset of spleen enlargement were found to be dependent on the number and source of cells tested. The effect of several immunosuppressive agents was examined. Amantadine was found to suppress completely the graft-vs.-host reaction in vitro when present at a concentration of 75 microg/ml. Pretreatment of effector cells with mitomycin C prevented their subsequent ability to cause a graft-vs.-host reaction. The effect of X irradiation on immunocompetence of spleen cells in vitro paralleled the known effect of irradiation on in vivo immunocompetence. Preimmunization did not increase the number or effectiveness of immunocompetent cells when measured under standard in vitro conditions. Preimmunization did, however, permit persistence of immunocompetence after immunosuppressive doses of X irradiation. Studies using congenic lines, moreover, indicated that the preimmunization effect could be demonstrated in strain combinations differing only in factors determined by the H-2 complex of genes. A weak graft-vs.-host reaction could be detected in strain combinations not involving differences at the H-2 locus. The potential of the in vitro graft-vs.-host reaction as a highly reproducible, quantifiable, internally controlled, and experimentally accessible system for study of such critical problems as cell differentiation and cell interactions is discussed.


Hormone-like activity of a thymus humoral factor on the induction of immune competence in lymphoid cells. Experiments reported here were performed to understand the mechanism by which THF increases the immunocompetence of spleen cells from NTx mice. Dibutyryl cAMP or substances which increase intracellular levels of cAMP in lymphocytes such as Poly(A:U), theophylline, or PGE(2) were shown to mimic the effect of THF and confer reactivity in an in vitro GvH response to spleen cells from NTx mice. Flufenamic acid, an antagonist to PGE(2), was shown to inhibit the induction of competence by this substance. It was found that THF induces competence by activating membranal adenyl cyclase which leads to a rise in intracellular cAMP in thymus-derived cells only. These biochemical changes occur before antigenic stimulation and are unrelated to antigenic challenge. These findings indicate that THF exerts its effect via cAMP and are in agreement with the concepts which permit to classify THF as a thymus hormone.


Evidence for an inhibitory product-cytochrome P-450 complex generated during benzphetamine metabolism by liver microsomes.


Transaminases in rat retina during development.


Accumulation of adenosine cyclic 3',5'-monophosphate in rat cerebral cortical slices. Stimulatory effect of alpha and beta adrenergic agents after treatment with 6-hydroxydopamine, 2,3,5-trihydroxyphenethylamine, and dihydroxytryptamines.


Effects of tranquilizers on the glutamate dehydrogenase-glutamate-oxalacetate transaminase complex.


Reserpine-like effects of harmine on isolated adrenal medullary vesicles.


Evidence against participation of cytochrome b5 in the hepatic microsomal mixed-function oxidase reaction.


Regulation of the adenosine cyclic 3',5'-monophosphate content of rat cerebral cortex: ontogenetic development of the responsiveness to catecholamines and adenosine.


The mechanism of infection in patients with diabetes mellitus: a review of leukocyte malfunction.


Editorial: Hypertonic glucose and improved critical organ performance.


Drug and alcohol abuse among psychiatric admissions. A multidrug clinical-tosicologic study.


Specific indications for different classes of phenothiazines.


Altered heat-lability of a fraction of glutathione reductase in aging human lens. An unusually heat-labile fraction of glutathione reductase appears in human lens at about an age of 32 years. No such change was found in glucose 6-phosphate dehydrogenase nor in 3-phosphoglycerate kinase. The change is an intrinsic property of glutathione reductase. A greater proportion of the altered glutathione reductase was found in the core, the older part, of the lens. No evidence of a second band of activity was obtained after electrophoresis. Possible interpretations of the results, including errors of protein synthesis, production of a new isoenzyme and post-synthetic changes, are discussed.


Membrane differentiation in phototrophically growing Rhodospirillum rubrum during transition from low to high light intensity.


N-oxidation of a tertiary amine (N,N-dimethylaniline) by human fetal liver microsomes.


Integration efficiency in DNA-induced transformation of Pneumococcus. I. A method of transformation in solid medium and its use for isolation of transformation-deficient and recombination-modified mutants. A method of transformation on solid medium especially adapted for pneumococcus has been developed. Under specific conditions, all colonies that are allowed to grow in the presence of transforming DNA for six hours give rise to transformed bacteria. Combined with replica plating this technique has been used to isolate mutants modified with regard to recombination. Most of the mutants found are transformation-defective and show a large diversity in their response to ultraviolet light. Some of these mutants have lost their ability to take up transforming DNA. One shows a reduced yield of transformants for a given quantity of DNA taken up. Mutants that manifest altered behavior with regard to marker efficiencies have also been isolated. One of these exhibits a decrease in the transformation efficiency of only the high efficiency markers and two mutants show a decrease in the transformation efficiency of the low efficiency markers.


Integration efficiency in DNA-induced transformation of Pneumococcus. II. Genetic studies of mutant integrating all the markers with a high efficiency. Transformation of the pneumococcus mutant 401 by DNA's bearing the standard reference marker and several other markers belonging to two unlinked loci has shown that differences in the integration efficiencies of these markers were considerably reduced in this strain compared to the wild-type strain Cl(3). The sensitivities of mutant 401 to ultraviolet light and to X-ray irradiation are the same as those of Cl(3). However, in 401 all the markers tested are more resistant to inactivation as shown by transformation of 401 and Cl(3) by ultraviolet-irradiated DNA. The increase in resistance is greater for low efficiency (LE) markers than for high efficiency (HE) markers.-The decreased discrimination between LE and HE markers in strain 401 is not due to a mechanism related to modification of markers in the transforming DNA by the recipient cells, nor are the proteins inducing competence of the cells responsible for the differences in the integration efficiencies of various markers.-Genetic studies of the fate of recombinants as well as the measure of the amount of DNA taken up have shown that all the markers are integrated in strain 401 by the same recombination process, that specific to high efficiency markers.


The regulation of fatty acid synthesis in human skin fibroblasts. Inhibition of fatty acid synthesis by free fatty acids.


Studies on the tryptophan and drug-binding properties of human serum albumin fragments by affinity chromatography and circular dichroism measurements.


Specificity in the association of glyceraldehyde 3-phosphate dehydrogenase with isolated human erythrocyte membranes.


Stimulation of taurodeoxycholate 7alpha-hydroxylase of rat liver by adenosine 3':5'-monophosphate and saturated fatty acids.


Sequential solubilization of microsomal mixed function oxidases.


The mechanism of activation of glutamate dehydrogenase-catalyzed reactions by two different, cooperatively bound activators.


Hepatic organelle interaction. 3. Mitochondrial modification of microsomal drug metabolism.


Regulation of de novo fatty acid biosynthesis in the n-alkane-utilizing yeast, Candida 107.


Abnormally low activities of fumarate hydratase and malate dehydrogenase in oxygen-sensitive cultures of Spirillum volutans.


Depressive effect of 7,12-dimethylbenz(alpha)anthracene and ionizing irradiation on bone marrow colony-forming cells.


Parameter sensitivity in insect population modeling.


The surgeon's assistant must be more than just a title.


Tetanus: principles of management and review of 37 cases.


Effect of chronic exposure to carbon disulphide upon some components of the electron transport system in rat liver microsomes.


Influence of non-steroid anti-inflammatory and immunosuppressive drugs on hepatic tryptophan pyrrolase activity in rats.


Differential sensitivity of rat liver and rat hepatoma cells to alpha-amanitin.


A simple general method for the preparation of "6-immobilized" analogues of AMP, ATP, NAD and of other adenine-containing compounds for affinity chromatography.


Effect of catecholamines on plasma growth hormone in dogs.


Warfarin resistance and DT diaphorase activity in the rat.


Strain differences in liver DT diaphorase activities.


The template binding and self-assembly in the reconstitution of microsomal redox chains: electron carriers which do and do not bind with microsomal membranes.


Localization of glutaminase in rat liver.


Electrophoretic characterization of classical Tetrahymena pyriformis strains.


Inconstant association of aequorin luminescence with tension during calcium release in skinned muscle fibres.


Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells.


Guest editorial: The 15th Quadrennial Congress of the International Council of Nurses and continuing education.


Guanylate cyclase: inhibition by light in retinal photoreceptors. Guanylate cyclase activity of retinal rod outer segments was measured by an assay procedure that minimizes the technical problems caused by the high activity of cyclic nucleotide phosphodiesterase in neural tissue. Cyclase activity in rods is significantly higher than in brain. Moreover, activity is two-fold higher in dark-adapted rods than in light-bleached rods, a sensitivity that is lost when the preparation is treated with detergent.


Antireceptor antiserum causes specific inhibition of reactivity to rat histocompatibility antigens. The antigen receptor of lymphocytes destined to form antibody appears to have the characteristics of the immunoglobulin produced. Antibody directed against the combining region of this immunoglobulin should interact with the combining region of the cell receptor for the antigen. Purified Lewis rat alloantibody prepared against Brown Norway (BN) rat histocompatibility antigens was used to immunize L x BN F(1) hybrids. The resultant antiserum has anti-receptor activity because (i) it yields precipitin lines in gel diffusion when reacted against the immunizing alloantibody; (ii) it inhibits the hemagglutinin antibody response of Lewis rats to BN histocompatibility antigens; and (iii) it inhibits the local graft-versus-host response of Lewis lymphoid cells against BN antigens. This suggests that antireceptor antibody may inhibit cell-mediated responses as well as antibody responses to histocompatibility antigens and may play a role in the regulation of immune responses to such antigens.


Marker discrimination in transformation and mutation of pneumococcus. Earlier investigations of pneumococcal transformation revealed a function (hex(+)) responsible for severely reducing the transformation yield of certain markers. A mutational alteration (hex(-)) responsible for the loss of this function has been transferred into a hex(+) strain to permit a comparison of the hex(+) and hex(-) phenotypes in an isogenic background. The loss of the hex(+) function results both in a loss of the capacity to eliminate the low efficiency markers in transformation and a substantial increase in the spontaneous mutation rate. These properties of the hex(-) strain could result from the loss of a capacity to eliminate certain classes of mismatched base pairs that occur as intermediates in both transformation and mutagenesis.


Inhibition of the oxidation of glutamate and isocitrate in liver mitochondria at a specific NADP+-reducing site. The cation-complexing carboxylic-acid antibiotic X-537A, at concentrations far below that required for ionophorous activity, selectively inhibits the oxidation of glutamate and isocitrate by liver mitochondria in steady-state 3. The site of inhibition has been localized specifically at the reduction of NADP(+). Glutamate and isocitrate dehydrogenases, the oxidation of NAD(+)-dependent substrates, pyridine nucleotide transhydrogenations, and the respiratory chain between NADH (or NADPH) and O(2) are unaffected by the antibiotic X-537A. Kinetic evidence, i.e., competition between chlorotetracycline (a fluorescence probe for membrane-bound bivalent cation) and X-537A, indicates that the NADP(+)-reducing, antibiotic-sensitive site is most probably associated with the inner mitochondrial membrane.


The optimum age to correct cryptorchidism.


Preoperative localization of pheochromocytoma.


Comparison of the antihistaminic effect of burimamide and mepyramine and their effect on the activity of histamine methyltransferase.


Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro.


Enzymatic studies on the metabolism of the tetrahydrofurfuryl mercaptan moiety of thiamine tetrahydrofurfuryl disulfide. 3. Oxidative cleavage of the tetrahydrofuran moiety.


Enzymatic studies on the metabolism of the tetrahydrofurfuryl mercaptan moiety of thiamine tetrahydrofurfuryl disulfide. II. Sulfide and sulfoxide oxygenases in microsomes.


Non-mitochondrial electron transfer system in anaerobically grown yeast cells.


The effect of 0.2 percent sodium fluoride mouthrinse in the prevention of dental caries in school children born and reared in a non-fluoridated community.


Selective blocking action of hexamethonium on the inhibitory postsynaptic responses of aplysia ganglion cells.


Immunodeficiency and cancer.

Immunodeficiency and cancer.


Effect of trimetoquinol on skeletal muscle contraction in rabbits. Comparison with epinephrine and isoproterenol.


Role of peroxide in phagocytic killing of pneumococci. Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.


The threat of the physician's assistant; implications for nursing education.


The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by adrenaline, ouabain and Mn++. 1. The mechanism of stimulation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) accumulation by adrenaline and ouabain and the effect of Mn(++) substitution for Mg(++) as the metal ion requirement of this system was studied in cell-free preparations of adenyl cyclase from rat brain.2. In the rat cerebral cortex preparation, substitution of Mn(++) for Mg(++) significantly increased cyclic AMP accumulation while significantly inhibiting adenosine triphosphate (ATP) and adenosine diphosphate (ADP) hydrolysis and adenosine 5'-monophosphate (AMP) accumulation. In the synaptic membrane preparation, in the absence of NaF, the highest amount of ATP hydrolysis was obtained in tissue prepared with Mn(++) and incubated with Mg(++); under these conditions cyclic AMP accumulation was equal to that produced under any other condition and significantly higher than that observed in the presence of Mg(++) prepared and Mg(++) incubated tissue.3. Preparation and/or incubation of tissue with Mn(++) significantly reduced phosphodiesterase (PDE) activity compared to that observed in Mg(++) prepared tissue.4. Adrenaline and ouabain both significantly increased cyclic AMP accumulation in the rat cerebral cortex preparation but did not inhibit ATP or ADP hydrolysis. In the synaptic membrane preparation, in the presence of 0.01 mM Ca(++), adrenaline but not ouabain significantly increased cyclic AMP accumulation. Phenoxybenzamine (0.1 mM) and pronethalol (0.1 mM) significantly inhibited adrenaline-induced cyclic AMP accumulation in both these preparations.5. Ouabain and adrenaline both failed to stimulate cyclic AMP accumulation in the presence of Mn(++) prepared and/or incubated tissue.6. Ouabain and adrenaline had no effect on PDE activity in either of these preparations.7. It was concluded that Mn(++) increased cyclic AMP accumulation in part by indirect inhibition of ATP and ADP hydrolysis which provides inhibitors of cyclic AMP destruction, by direct stimulation of adenyl cyclase and by inhibition of cyclic AMP destruction in a way unrelated to nucleotide inhibition of PDE. Adrenaline and ouabain appeared tp stimulate cyclic AMP accumulation in a more direct manner.


Trans-synaptic regulation of adrenergic neuron development: inhibition by ganglionic blockade.


Studies on the identity of the optic nerve transmitter.


Brain (NA+ + K+)-activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats.


Central actions of shikimin and tutin.

Central actions of shikimin and tutin.


Demonstration of serum gamma-glutamyl transpeptidase isoenzymes using cellogel electrophoresis.


Ecological studies on the breeding of Aedes aegypti and other mosquitos in shells of the giant African snail Achatina fulica. The breeding of larvae of Aedes aegypti, Aedes simpsoni, and Eretmapodites quinquevittatus in empty shells of Achatina fulica was studied in the coastal zone of Dar es Salaam, Tanzania. The average density of shells was estimated to be 228 per ha. From 11 to 35% were positive for mosquito larvae. A. aegypti were found in 82-84% of positive shells; A. simpsoni in 8-13%. On Msasani peninsula, during the 3-month rainy season April-June 1970, the larval density of A. aegypti in shells was estimated at 1 100 per ha, that of A. simpsoni and E. quinquevittatus being estimated at 60 and 280 larvae per ha, respectively.Empty shells of A. fulica may contain up to 250 ml of water (average: 56.5 ml). The number of larvae per shell varies from 1 to 35 (average: 8.4) and it was estimated that, depending on the availability of food, and other factors, approximately 10 ml of water are required per larva. Viable eggs of A. aegypti were still to be found in 4% of the shells at the end of the dry season.


Peroxisomes and hydrogenosomes in protozoa.


Combined use of ECT and psychotropic drugs: antidepressives and antipsychotics.


Anatomy and innervation ratios in motor units of cat gastrocnemius. 1. Muscle fibres belonging to single motor units of identified type were studied in frozen sections of cat medial and lateral gastrocnemius muscles. Reconstruction of the distribution of fibres in individual units showed that the territories of all three physiological types present in the cat medial gastrocnemius were quite extensive. Within its territory, fibres belonging to the studied unit were distributed more or less uniformly without localized collections. The density of unit fibres suggests that, in cat medial gastrocnemius, a given region of the muscle may be shared by as many as fifty different muscle units.2. Direct determination of innervation ratios in identified muscle units required complete reconstruction of the three-dimensional distribution of unit fibres within the whole medial gastrocnemius. Satisfactory results were obtained with two type FF units and one type FR unit.3. Indirect estimates of the average innervation ratios expected for muscle units of different physiological type were obtained using counts of muscle fibres with characteristic histochemical profiles and data on relative frequencies of motor units of known type in the medial gastrocnemius unit pool. Such indirect estimates of innervation ratios agreed with the results of direct fibre counts in identified units for types FF and FR muscle units. Taken in sum, the available evidence suggests that an average muscle unit in the cat medial gastrocnemius contains between 400 and 800 muscle fibres, irrespective of physiological type.4. Tension production by single muscle units depends on a number of factors, including innervation ratio, the cross-sectional areas of unit fibres and the specific tension outputs of the unit fibres. The present results suggest that the specific tension output of gastrocnemius type S unit muscle fibres is considerably smaller (about 0.6 kg/cm(2)) than in either FF units (about 1.5-2.0 kg/cm(2)) or type FR units (2.6-2.9 kg/cm(2)).


Physiological types and histochemical profiles in motor units of the cat gastrocnemius. 1. A variety of physiological properties of single motor units have been studied in the gastrocnemius muscle (primarily in the medial head) of pentobarbitone-anaesthetized cats. Intracellular stimulation of individual motoneurones ensured functional isolation of the muscle units innervated by them.2. A system for muscle unit classification was developed using a combination of two physiological properties. Almost all of the units studied could be classified into one of three major types, including two groups with relatively short twitch contraction times (types FF and FR, which were differentiable from one another on the basis of sensitivity to fatigue) and one group with relatively long contraction times (type S, which were extremely resistant to fatigue and were differentiable from FF and FR units on the basis of the shape of unfused tetani). Post-tetanic potentiation of twitch responses was observed in all three muscle unit types. The distributions of axonal conduction velocities for motoneurones innervating FF and FR muscle units were essentially the same, while conduction velocities for motoneurones innervating type S units were, in general, slower.3. Histochemical profiles of muscle units representative of each of the physiological classes present in the gastrocnemius pool were determined using a method of glycogen depletion for muscle unit identification. Each of the physiological categories of muscle units exhibited a corresponding unique set of muscle fibre staining reactions, or histochemical profile. Within each physiological type, all of the units examined had the same histochemical profile. The results generally support the hypothesis that the histochemical characteristics of muscle fibres are meaningfully related to the physiological properties of the same fibres. However, certain limitations in the detailed application of the hypothesis were also apparent.4. Systematic assessment of the histochemical profiles of relatively large numbers of fibres belonging to single muscle units provided strong support for the hypothesis that all of the muscle fibres innervated by a single alpha-motoneurone are histochemically identical.


New concepts in asthma.

New concepts in asthma.


The effects of physostigmine in phenothiazine resistant chronic schizophrenic patients: preliminary observations.


An MMPI scale to measure scholastic personality in women.


Submicrosomal distribution of hepatic drug-metabolizing components in the Gunn rat.


Recovery from chronic idiopathic bone marrow aplasia of a young mother after intravenous injection of unprocessed cells from the liver (and yolk sac) of her 22 mm CR-length embryo. A preliminary report.


Isolation of acetyl CoA apocarboxylase by sepharose-avidin affinity chromatography.


The function of ubiquinone in Klebsiella aerogenes.


Maternal medication and its effect on the fetus.


Transfer ribonucleic acid in hepatoma tissue culture cells. I. Induction in vivo by dexamethasone phosphate of phenylalanine-accepting activity.


Effects of secretin on guanyl cyclase of various tissues.


Purulent pericarditis: a review of diagnostic and surgical principles.


Letter: Beta receptors and renin release.


Mapping of the structural genes of the three aspartokinases and of the two homoserine dehydrogenases of Escherichia coli K-12. Mutants requiring threonine plus methionine (or homoserine), or threonine plus methionine plus diaminopimelate (or homoserine plus diaminopimelate) have been isolated from strains possessing only one of the three isofunctional aspartokinases. They have been classified in several groups according to their enzymatic defects. Their mapping is described. Several regions of the chromosome are concerned: thrA (aspartokinase I-homoserine dehydrogenase I) is mapped in the same region as thrB and thrC (0 min). lysC (aspartokinase III) is mapped at 80 min, far from the other genes coding for diaminopimelate synthesis. metLM (aspartokinase II-homoserine dehydrogenase II) lies at 78 min closely linked to metB, metJ, and metF.


A demonstration of vagal adrenergic vascular and motor influences in the small intestine of the dog.


Sympathectomy and pharmacological blockade in trained rats.


Tension perception in patients having pain associated with chronic muscle tension.


Active unit of D-amino acid oxidase from hog kidney.


Cytochemical and pharmacological studies on polysensory neurons in the primate frontal cortex.


Two male sibs with uterus and Fallopian tubes. A rare, probably inherited disorder.


Dystonic reactions to drugs.

Dystonic reactions to drugs.


Mitogenic properties of the thymus-independent antigen pneumococcal polysaccharide S3.


The time course of pacemaker inhibition in the hydroid Tubularia.


Conversion of glutamic acid to glutamine by retinal glutamine synthetase.


Patterns of transcription in Bacillus subtilis during sporulation.


Activation of leukemia viruses by graft-versus-host and mixed-lymphocyte-culture reactions: electron microscopic evidence of C-type particles.


Tumor growth and disulfide reduction: possible dependence on protein-disulfide reductase.


Prolonged diarrhoea in a child with severe combined immunodeficiency.


QtU-abnormalities, sinus bradycardia and Adams-Stokes attacks due to ventricular tachyarrhythmia.


New drug development--expectations and speculations.


Drug effects on pre- and post-branchial blood pressure and heart rate in a free-swimming marine teleost, Gadus morhua.


Renal vascularity in the dog--alpha-adrenergic blockade and acute hemorrhage.


Detection of oxidases on polyacrylamide gels.


Effects of isoetharine on airways resistance, heart rate, and contractions of the soleus muscle of the anaesthetised cat.


Effects of propranolol and a new 'cardioselective' beta-blocker, H 93-26, on responses of isolated rat atria to isoprenaline and noradrenaline.


Synthesis of cephapirin and related cephalosporins from 7-(alpha-bromoacetamido)cephalosporanic acid.


Symptomatic treatment of adults with bronchial asthma.


Letter: Pneumococcal typing sera.

Letter: Pneumococcal typing sera.


Rhinitis.

Rhinitis.


Sources of leukocytic endogenous mediator in the rat.


The interpretation of findings in clinical caries trials.


Translation. XO-XY mosaics: six case studies.


Stimulation of ovulation with F-6066 cyclofenil: bis-(p-acetoxyphenyl)-cyclohexylidenemethane.


Effects of diphenylhydantoin upon estrogen metabolism by liver microsomes of DDT-treated Japanese quail.


Thiol-protein disulfide oxidoreductase activity in lactating and non-lactating mouse mammary gland.


Stimulation of intestinal adenyl cyclase by Escherichia coli enterotoxin: comparison of strains from an infant and an adult with diarrhea.


Acidaemia produced by spinal stimulation in the pithed rat. 1. Electrical stimulation of the thoraco-lumbar spinal nervous outflow in the pithed rat preparation produces a fall in arterial blood pH.2. A component of the acidaemic response results from stimulation of skeletal muscle, since the acidaemic response is reduced when contractions of muscle are blocked with gallamine.3. The residual acidaemic response in gallamine-treated rats is reduced by adrenalectomy, suggesting that catecholamines liberated from the adrenal medulla may mediate part of the effect.4. Guanethidine reduces the acidaemic response remaining in adrenalectomized, gallamine-treated rats, suggesting that the effect of noradrenaline released from sympathetic nerve endings contributes to the fall in pH.5. Neither phenoxybenzamine nor propanolol alone significantly reduces the acidaemic response in gallamine-treated rats, but a combination of the two antagonists almost abolishes the effect. Hence the acidaemia is mediated through effects of catecholamines on both alpha- and beta-adreno-receptors.6. Since acidaemia affects responses to sympathetic nerve stimulation and sympathomimetic amines, the significance of these observations is discussed with reference to the use of the pithed rat preparation for assessment of drugs affecting adrenergic mechanisms.


Studies on the function of cell membrane. 2. Elevation of NADH-cytochrome c reductase activity in the liver cell membrane of rats following CCl4 administration.


Perturbation of growth and metabolism in Candida albicans by 4-bromobenzyl isothiocyanate and iodoacetate.


Studies on the function of cell membrane. 3. On the purity of liver cell membrane fraction isolated from CCl4-treated rats.


Antihistaminic and spasmolytic effects of musk.


Studies on the function of cell membrane. 5. Characterization of NADH-cytochrome c reductase of liver cell membrane in normal and CCl4-treated rats.


Pharmacological properties of electrical activities obtained from neurons in Auerbach's plexus.


Effect of histamine, bradykinin and morphine on adrenaline release from rat adrenal gland.


Dissociation of stimulatory and synthetic phases in the induction of tyrosine hydroxylase.


Analysis of contractions induced by transmural stimulation in the isolated sphincter of Oddi.


Retinal structure in Latimeria chalumnae.


Animal health.

Animal health.


Substitute foods-a practical alternative?


Functional morphology with particular reference to hinge and ligament in Spondylus and Plicatula and a discussion of relations within the superfamily Pectinacea (Mollusca: Bivalvia).


The biomass and distribution of organisms in Lake George, Uganda.


32-Msec scan of the NAD(P)H fluorescence spectrum in single living cells.


Influence of the cell surface lipopolysaccharide structure of Salmonella typhimurium on resistance to intracellular bactericidal systems.


The effect of acute and chronic methadone treatment on the in vitro N-demethylation of methadone by microsomal enzymes of male and pregnant and nonpregnant female rats.


Prevention of serotonin abortion by serotonin antagonists in rats.


Comparative effects of sotalol and propranolol on myocardial contractility.


Selective beta blockade of isolated rabbit detrusor muscle with practolol (AY21,011) and N-isopropylmethoxamine.


Pathogenesis of the graft-versus-host reaction in chicken embryos. Requirement of yolk sac-derived stem cells for the development of proliferative lesions.


Effect of isoprenaline on the response of the rabbit ear artery to electrical stimulation.


Inhibition by acetamidophenol of the production of prostaglandin-like material from blood platelets in vitro in relation to some in vivo actions.


Vagally induced tachycardia in atropinized dogs: effect of beta-adrenergic blockade.


Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.


A possible mechanism of action of a central stimulant substance isolated from the sea anemone Stoichactis kenti.


Effects of a central stimulant substance isolated from the sea anemone Stoichactis kenti on brain monoamines of the mouse.


Self-ratings of alienation in suicidal patients.


A simple bivariate screening technique to separate NP hospital organics from other psychiatric groups.


Relationships among discharge variables and MMPI scale scores of hospitalized alcoholics.


Race-related and educationally-related MMPI profile differences among hospitalized schizophrenics.


MMPI differentiation of multiple sclerosis vs. pseudoneurologic patients.


Degree of agreement among MMPI scores, self-ratings, and staff ratings of inpatient adolescents.


Application of the Midi-Mult to psychiatric inpatients.


Modification by enzyme-inducing drugs of the anticonvulsant action of phenytoin.


A comparison of the MMPI and Mini-Mult in a sample of state mental hospital patients.


Effects of histamine and pheniramine maleate on protease activity of sheep brain.


Development of a social desirability and acquiescence controlled Repression Sensitization Scale and some preliminary validity data.


Emotional functions in short-term vs. long-term L-Dopa therapy in Parkinsonism.


Loss of discriminative "power" of the MMPI with older psychiatric patients.


Multimethod analysis of three measures of six common personality traits.


Bladder exstrophy: vesicoplasty or urinary diversion?


Single ectopic ureter in the male.

Single ectopic ureter in the male.


Effect of chronic treatment with ACTH on 11 beta-hydroxylation in rat adrenal mitochondria.


Postmortem bacteriology. 3. Clinical significance of microorganisms recovered at autopsy.


The role of local-anesthetic effect in the inhibition of glycogenolysis in the liver of the rat.


Prevention of graft versus host reaction by incubation of lymphoid cells with a splenic extract (not affecting the repopulation of the haemopoietic tissue).


The effect of ethionine on the energy producing metabolism in the rat pancreas. 1. The influence on the activities of key enzymes of various metabolic pathways.


An evaluation of new primary pediatric paraprofessionals.


Letter: "That magnificent volume".

Letter: "That magnificent volume".


Proceedings: The effect of an H2-receptor antagonist on histamine-stimulated acid secretion by rat stomach in vitro.


The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non-adrenergic inhibitory innervation. 1. The earliest components of the developing innervation of the rabbit intestine to be detected in this study were the cholinergic excitatory and the intrinsic inhibitory innervation. These developed simultaneously in the rabbit at 17 days of gestation. Both were also present in the mouse by the 16th day of gestation. Responsiveness of rabbit tissue to exogenous acetylcholine appeared together with the advent of a functional cholinergic innervation. Since excitatory responses were potentiated by eserine, the tissue was probably able to inactivate acetylcholine through hydrolysis mediated by cholinesterase. Early relaxant responses resisted blockade by adrenergic neurone blocking agents and by antagonists active at alpha- and beta-adrenoceptors.2. The development of the adrenergic innervation lagged far behind that of the other two components. Specific uptake of noradrenaline in the rabbit was detected for the first time at the 21st day of gestation and stores of noradrenaline could not be detected histochemically until 26-28 days. However, relaxant responses to stimulation of the perivascular sympathetic supply, such as characterize adult tissues, had not yet developed by the time of birth. Relaxation in response to perivascular stimulation could be seen 30 days after birth.3. Morphologic studies indicated that the longitudinal layer of smooth muscle was very primitive when an effective innervation was established. Although contractile, the cells were still myoblasts. Neural elements also appeared primitive. Thus considerable morphological maturation follows the development both of a functioning contractile machinery and innervation in the foetal gut.4. This study helps establish that the intrinsic inhibitory innervation of the gut is not adrenergic.


The optimum time to operate for cryptorchidism.


Kinetics of control enzymes.

Kinetics of control enzymes.


Pyridine nucleotides and rate control.

Pyridine nucleotides and rate control.


The control of flux.

The control of flux.


Regulation of enzymes by covalent modification including hydrolysis of peptide bonds.


Sex-linked abrogation of the graft-versus-host reaction.


Prolongation of skin allograft survival with antilymphocyte serum and soluble histocompatibility antigens.


Specific unresponsiveness to skin allografts in mice. II. The mechanism of unresponsiveness induced by tissue extracts and antilymphocytic serum.


Mixed leukocyte culture reactivity and chronic graft-versus-host reactions (secondary disease) between allogeneic H-2k mouse strains.


The sensitivity of mycoplasmatales to sodium-polyanethol-sulfonate and digitonin.


The role of fimbriae in the processes of infection. Preliminary report.


Influence of incubation temperaure on interferon mechanism in cells of Testudo graeca kidney.


Influence of sulfonamide antagonists on the synergism of sulfamethoxazole-trimethoprim in Escherichia coli.


Listeria monocytogenes-haemolysin: lecithinase.


The effect of NaCl on the morphology of listeria monocytogenes.


Urease as a useful criterion in the classification of microaerophilic actinomycetes.


On the systematic position of microaerophilic, aerial mycelium forming actinomycetes of trutnov 139--66 typ.


Significance of intermediary reduction products in the histochemical demonstration of dehydrogenase activity.


Clinical experience with 19.552 R.P. in Nordic countries.


Report of a conference on protein and amino acid needs for growth and development.


Microbiological profiles of four Apollo spacecraft. Selected surfaces from the Command Module, Lunar Module (ascent and descent stages), Instrument Unit, Saturn S-4B engine, and Spacecraft Lunar Module Adapter comprised the various components of four Apollo spacecraft which were assayed quantitatively and qualitatively for microorganisms. In addition, the first Lunar Roving Vehicle was assayed. Average levels of microbial contamination (10(4) per square foot of surface) on the Command Module, Instrument Unit, and Saturn S-4B engine were relatively consistent among spacecraft. The first postflight sampling of interior surfaces of the Command Module was possible due to elimination of the 21-day back-contamination quarantine period. Results of the pre- and postflight samples revealed increases in the postflight samples of 3 logs/inch(2). A total of 5,862 microbial isolates was identified; 183 and 327 were obtained from the Command Module at preflight and postflight sampling periods, respectively. Although the results showed that the majority of microorganisms isolated were those considered to be indigenous to humans, an increase in organisms associated with soil and dust was noted with each successive Apollo spacecraft.


Activation of nitrate reductase from rice seedlings by NADH.