Nonthrombogenic plastic surfaces.

Nonthrombogenic plastic surfaces. Heparin has been chemically combined with a number of plastic surfaces rendering them nonthrombogenic as judged by Lee-White coagulation tests in vitro with human blood. Addition of quaternary ammonium groups to the plastic permitted formation of insoluble complexes with heparin. These heparinized surfaces were essentially nonthrombogenic and adsorb blood proteins to a significantly smaller degree from dilute solution than do the unmodified plastic surfaces. The affinity of the formed blood elements for these modified surfaces is much less than for the unmodified surfaces.


Tritiated norepinephrine: release from brain slices by electrical stimulation. Slices of rat brain and heart that had concentrated H(3)-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H(3)-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.


Staining tissue for light and electron microscopy by bridging metals with multidentate ligands. "Osmium black," a pigment very useful for cytological staining in both light and electron microscopy, may be deposited selectively at the tissue-binding sites of other metal ions by bridging OsO(4) to the tissue bound metal ion through a multidentate ligand.


Isoniazid with thiacetazone (thioacetazone) in the treatment of pulmonary tuberculosis in East Africa--third investigation: the effect of an initial streptomycin supplement.


An international co-operative investigation into thiacetazone (thioacetazone) side-effects.


Adult hypoglycaemia associated with neoplasia. A report of three cases with a note on the use of diazoxide.


Prostatic obstruction in the African and Asiatic.


Palliation and life prolongation with anticancer drugs.


The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.


Rabbit lymphoid cells differentiated with respect to alpha-, gamma-, and mu- heavy polypeptide chains and to allotypic markers Aa1 and Aa2. Lymphoid cells present in spleen and lymph nodes of hyperimmune rabbits were found to be differentiated with respect to the class of immunoglobulin heavy chain which they contained. The relative proportions of cells containing the various heavy chains were as follows: alpha-chain (5 to 8%), micro-chain (14 to 21%), and gamma-chain (71 to 81%). The allotypic markers Aa1 and Aa2, found on heavy chains, were also found to be separately localized in cells of Aa(1)/Aa(2) heterozygous rabbits. The ratio of cells in spleen and lymph nodes containing the Aa1 marker to those containing the Aa2 marker varied with individual rabbits; the range was 53 to 88% Aa1 versus 12 to 47% Aa2.


Electrophoretic heterogeneity of polypeptide chains of specific antibodies. Heavy and light polypeptide chains isolated from different specific antibodies to haptens and from (gamma)G-immunoglobulin of normal rabbits have been resolved into distinct, multiple components by disc electrophoresis in polyacrylamide gels in the presence of urea. In spite of the resolution of these chains into multiple bands, different specific antibodies and normal rabbit (gamma)G-immunoglobulin were indistinguishable from each other by this method.


Effect of interferon on early interferon production. Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.


Lymphoid cells producing antibody against simple haptens: detection and enumeration. Enumeration of cells producing antibody against arsanilic acid was made feasible by the use of hapten-conjugated sheep erythrocytes for the localized hemolysis-in-gel technique. The time of appearance and numbers of these hapten-specific plaque-forming cells correlated closely with the development of arsanilic acid-specific serum antibodies.


Prosthetic treatment for palatopharyngeal incompetence: research and clinical implications.


The relationship of thyroid disease and the atopic state.


Technique for visualizing papovaviruses in tumors and in tissue cultures.


Growth, morphogenesis, and virulence of Candida albicans after oral inoculation in the germ-free and conventional chick. Balish, Edward (Syracuse University, Syracuse, N.Y.), and A. W. Phillips. Growth, morphogenesis, and virulence of Candida albicans after oral inoculation in the germ-free and conventional chick. J. Bacteriol. 91:1736-1743. 1966.-The effects of intestinal bacteria on the multiplication, morphogenesis, and infectivity of Candida albicans in the alimentary tract were investigated by comparing results obtained in germ-free and conventional chicks after oral inoculation. This challenge resulted in the establishment of large numbers of the pathogen in the alimentary tract of each group of chicks; these numbers were increased in crop contents from challenged bacteria-free chicks wherein hyphae predominated over the yeast form. These animals also had lesions of the crop epithelium containing numerous hyphae and few yeast-like forms. In contrast, challenged conventional chicks receiving an adequate diet displayed no evidence of infection. Their alimentary tract contained the yeast form of C. albicans; no hyphae were seen. Although we found bacterial inhibition of C. albicans multiplication in the alimentary tract, this in itself did not seem to explain the resistance to intestinal candidiasis in our conventional chicks. We argued that this resistance to infection was due chiefly to the prevention of hyphal development in C. albicans by intestinal bacteria. C. albicans in the gut of our conventional chicks resulted in some increase in numbers of enterococci in contents from the crop. Increased pH values in contents from the gut of germ-free chicks were not clearly related to infection after challenge. The E(h) of the above crop contents were only slightly decreased in the germ-free crop. Thus the E(h) did not appear to be involved in susceptibility to infection. Invasion of the blood stream and kidneys of conventional chicks by the yeast form of C. albicans occurred in challenged animals receiving a purified diet which had been radiation-sterilized and stored for 6 months at room temperature (25 C). Their growth rate decreased and they became moribund; no hyphae were observed in tissues or intestine of these animals. Challenged bacteria-free chicks receiving the same diet were resistant to the above invasion, although they had crop lesions containing hyphae as described. The resistance of these chicks to systemic invasion was attributed to absence of intestinal bacteria competing for low levels of vitamins in the stored diet. Germ-free chicks had decreased levels of serum gamma-globulin which increased after challenge, whereas this value was unchanged in conventional birds after challenge.


Rubro-cerebellar connections in the cat: an experimental study with silver impregnation methods.


Filamentous and tubular structures in mammalian axoplasm. An electron microscopic study.


Growth and virulence of Candida albicans after oral inoculation in the chick with a monoflora of either Escherichia coli or Streptococcus faecalis. Balish, Edward (Syracuse University, Syracuse, N.Y.), and A. W. Phillips. Growth and virulence of Candida albicans after oral inoculation in the chick with a monoflora of either Escherichia coli or Streptococcus faecalis. J. Bacteriol. 91:1744-1749. 1966.-Bacterial protection against intestinal infection by Candida albicans was investigated in chicks with a monoflora of either Escherichia coli or Streptococcus faecalis. These animals were obtained by orally inoculating germ-free chicks (3 days old) with pure cultures of bacteria. Each bacterial species was established in large numbers in the gut of separate groups of animals within 24 hr of inoculation; these numbers were similar in chicks examined 34 days later, at which time all animals were killed. The numbers of bacteria from contents of the crop, small intestine, and ceca were similar in chicks with the E. coli monoflora. Comparable results were obtained in chicks with the S. faecalis monoflora, except for decreased numbers in the duodenum and jejunum. Some of the monoflora chicks (7 days old) were transferred into separate isolators, orally inoculated with C. albicans, and observed for 34 days. All chicks grew well and appeared healthy. However, examinations at autopsy revealed severe crop infections in chicks with a diflora containing S. faecalis. Preferential growth of hyphae (C. albicans) occurred in the lesions and throughout the gut. The numbers of S. faecalis in the gut were comparable to those found in unchallenged animals. Agglutinins against C. albicans were not detected in our test or control chicks. Chicks with a diflora containing E. coli and C. albicans had a few microscopic crop lesions containing small numbers of hyphae. C. albicans was well established in the gut of these animals, largely as the yeast form. The numbers of E. coli in the gut were similar to those in control chicks. Thus, it was concluded that E. coli provided protection against crop infection by C. albicans. In crop contents from unchallenged animals, chicks with S. faecalis monoflora were about pH 5, whereas birds with E. coli monoflora were about pH 7. The challenge did not greatly change the former value, and the latter was slightly decreased. In the crop of unchallenged birds, negative E(h) values were found in chicks with S. faecalis and positive E(h) values in those with E. coli. Challenge did not greatly change these values. These data on pH and E(h) were related to conditions for morphogenesis of C. albicans and virulence. No major difference in the concentrations of serum proteins was seen in chicks with E. coli or S. faecalis after challenge with C. albicans. Possible mechanisms of the protective effect of E. coli are discussed.


Some side effects of heparin, heparinoids, and their antagonists.


6-alpha-methyl- 17-alpha-hydroxyprogesterone acetate as a chemotherapeutic agent in adenocarcinoma of the uterus.


Antibody synthesis in poikilothermic vertebrates.


The accumulation of synthetic chelating agents in osseous tissues.


Further studies of the mechanism of passive sensitization. 1. The mechanism of passive sensitization of chopped guinea-pig lung when incubated with rabbit antiserum alone and in the presence of non-antibody gamma-globulin has been investigated.2. The effect of concentrations of antibody on the fraction of receptors occupied by molecules attached at one, two or three points has been calculated assuming mass action relations. If a single attachment is sufficient for sensitization the predicted log concentration-effect curve is S-shaped; if two or more attachments are needed the curve is bell-shaped. The effect of inhibiting non-antibody gamma-globulin on the shape and position of the curves has also been calculated.3. The effect of incubating with a wide range of concentrations of antibody on the subsequent histamine release with antigen has been determined. Bell-shaped curves were obtained. Their shape and position were altered by inhibiting non-antibody in a manner predicted by the two-point attachment hypothesis.4. The first affinity constants for antibody and non-antibody gamma-globulin have been calculated from the experimental concentration-effect curves. They are similar and have a value of about 10(7) l./mole. Approximate values for the second affinity constants and for the fraction of receptors effectively occupied at maximum sensitization have also been estimated.


Complications of diuretic therapy in hepatic cirrhosis.


Functional and metabolic effects of total and selective vagotomy.


Countercurrent exchange between the vasa recta and the loop of Henle.


Plasma thiocyanate and vitamin B12 in Nigerian patients with degenerative neurological disease.


Gastrointestinal protein loss measured with 59Fe-labelled iron-dextran.


Chronic portal-systemic encephalopathy after ileostomy and colonic resection.


Cholera in children.

Cholera in children.


An isothiazole thiosemicarbazone in the treatment of variola major in man. A controlled clinical trial and laboratory investigations.


Assessment of an isothiazole thiosemicarbazone in the prophylaxis of contacts of variola major.


Combined action of methyldopa and bethanidine. Evidence for a synergistic effect.


Administration of measles vaccine by dermojet.


Infusion of dextrose solution in cardiogenic shock.


Bladder retractor.

Bladder retractor.


Trace elements.

Trace elements.


Coronary angiography.

Coronary angiography.


Voluntary workers in a psychiatric hospital.


Suxamethonium and uterine activity.

Suxamethonium and uterine activity.


Tetracyclines and the teeth.

Tetracyclines and the teeth.


Postoperative infection with Pseudomonas aeruginosa in an eye hospital.


Radioimmunoassay for human chorionic gonadotrophin and luteinising hormone.


Cathartic colon.

Cathartic colon.


Effects of dextran 40 on erythrocyte aggregation.


Pulmonary aspiration of gastric contents in obstetric patients. A report of two patients treated by artificial ventilation.


Apparent cri-du-chat and "antimongolism" in one patient.


Minor ocular abnormalities associated with thalidomide.


Effect of thalidomide on the immunological response in local lymph nodes after a skin homograft.


Immunosuppression by thalidomide: implications for teratology.


Apparatus for turning patients.

Apparatus for turning patients.


Pseudomonas aeruginosa.

Pseudomonas aeruginosa.


Living records.

Living records.


Breathlessness.

Breathlessness.


Turner's Syndrome and phenotype.

Turner's Syndrome and phenotype.


The Christchurch chromosome.

The Christchurch chromosome.


Chromosomes in cleft-palate tissues.

Chromosomes in cleft-palate tissues.


Methyldopa and haemolytic anaemia.

Methyldopa and haemolytic anaemia.


Dehydroemetine in chronic leukaemia.

Dehydroemetine in chronic leukaemia.


Cyclophosphamide treatment of kidney disease in (NZB x NZW) F1 mice.


Observations on the mechanisms of infarction in the dog after experimental occlusion of the coronary artery.


Gastric secretory patterns before and after vagotomy.


T-strain mycoplasma in non-gonococcal urethritis.


Generalised vaccinia in the human foetus.


Increased dispersal of skin bacteria into the air after shower baths: the effect of hexachlorophene.


Arginine infusion in maturity-onset diabetes mellitus. Defective output of insulin and of growth hormone.


Relationship between postoperative changes in adenosine-diphosphate induced platelet adhesiveness and venous thrombosis.


The vascular fault in chronic hypertension with particular reference to the role of medial hypertrophy.


Lead absorption and lead poisoning.

Lead absorption and lead poisoning.


Diarrhoea and acid-base disturbances.

Diarrhoea and acid-base disturbances.


Adrenergic receptors.

Adrenergic receptors.


Follow-ups of elderly discharged patients.


Variola minor. A preliminary report from the Birmingham Hospital region.


Not to be left to nature.

Not to be left to nature.


Plaque localization and distribution of vasa vasorum. A micro-angiological study of the human abdominal aorta.


Ribonucleic acid content of Burkitt tumour cells. Methyl-green-pyronin-Y staining was performed on 57 biopsies of Burkitt's tumour and 62 biopsies from other types of malignant lymphoma. The specificity of the pyronin staining for ribonucleic acid (RNA) was controlled by staining duplicate slides previously digested in ribonuclease. Burkitt's tumour cells have a higher cytoplasmic content of RNA than the cells of most other malignant lymphomas. The results of acridine orange staining of a smaller number of biopsies support these findings.


Simultaneous demonstration of mast cells and plasma cells.


Granulocyte changes in infectious mononucleosis. Various changes in the granulocytes have been investigated in a large series of patients with infectious mononucleosis. A high proportion of cases regularly show a neutropenia with a shift to the left during the first three to four weeks of the disease; these changes, though transient, may be profound. The band cells present during the acute phase of the disease also show certain alterations in cytochemical staining and low alkaline phosphatase scores are common at this time. The maturation and release of leucocytes from the bone marrow is apparently normal. Theoretical mechanisms for the neutropenia are briefly discussed, including the possible role of excessive peripheral destruction.


Absence of alpha globulin from the egg white of the domestic turkey.


Oxygen consumption and NADPH oxidation in microsomes from vitamin K-deficient, warfarin- and dicumarol-treated rats.


Structural changes in the incisors of cortisone-treated rats.


Pathogenesis of hyaline formation in sarcoidotic lymph nodes.


Serum proteins and glucoproteins in sarcoidosis.


Vascular and nerve supply to the molar teeth of guinea pigs.


Serum proteins in sarcoidosis.

Serum proteins in sarcoidosis.


Whipple's disease: evolution of current concepts.


Oxytalan fibers in the periodontium of ascorbic acid-deficient guinea pigs.


A primary isolation medium. For the differentiation of genus Proteus from other non-lactose and lactose fermenters.


Primary biliary cirrhosis-positive antibody tests associated with increased immunoglobulin.


Biomechanical control of bone growth and development: a histologic and tetracycline study.


Whipple's disease with clinical remission induced by ampicillin.


Thyroid function and glaucoma.

Thyroid function and glaucoma.


Congenital indifference to pain.

Congenital indifference to pain.


The effects of chemical modifications of human gamma-globulins on their interaction with rheumatoid factors and antibodies.


Serum protein changes associated with Oesophagostomum columbianum infections in sheep.


Studies on nucleic acid metachromasy. I. The effect of certain fixatives on the dye stacking properties of nucleic acids in solution. The stacking coefficients (K's) of nucleic acids have been thought to influence the color contrast between DNA and RNA in tissue sections stained with metachromatic dyes. This idea was tested by titrating toluidine blue (TB) and acridine orange (AO) in solution against DNA and RNA, native or treated with formaldehyde, acrolein, or Carnoy's fluid. Absorption spectra at varying polymer-dye ratios were used to compute K values by the methods of Bradley and colleagues. Results with both dyes fit Bradley's stacking equations. Fixatives did not block dye-binding sites but markedly altered K values. K of DNA was low, unaffected by aldehyde fixative, increased by Carnoy's fluid or heat denaturation. K of RNA was higher than that of DNA and was increased greatly by formaldehyde, almost as much by acrolein, considerably less by Carnoy's fluid. Aldehyde effects were partially reversed upon removal of aldehyde by dialysis. These observations accord with known effects of aldehydes and denaturation upon nucleic acid conformation. Differences between K's of DNA and RNA were greater after aldehyde treatment than after Carnoy's, and were greater with AO than with TB. This is generally consistent with the magnitude of the color contrasts observed in tissues. Additional factors must contribute to the intense color contrast observed in acrolein-fixed tissues stained with TB.


Studies on nucleic acid metachromasy. II. Metachromatic and orthochromatic staining by toluidine blue of nucleic acids in tissue sections. Acrolein-fixed, polyester wax-embedded tissue sections showed excellent preservation of light microscopic architecture and, when stained with toluidine blue, intense color contrast between DNA, which stained orthochromatically, and RNA, which stained metachromatically. This method has practical value for differentiating DNA from RNA in the same section. The color contrast was impaired by substituting formaldehyde for acrolein or paraffin for polyester wax, and was negligible in tissues fixed in formaldehyde or Carnoy's fluid and embedded in paraffin. Quality of structural preservation paralleled degree of color contrast. Metachromatic staining can be analysed, by the quantitative parameters of Bradley and colleagues, to provide inferences regarding the conformation of biopolymers in tissue sections. Comparison of the nucleic acid color contrasts in toluidine blue-stained sections with titrations of fixative-treated nucleic acids against toluidine blue in solution indicated a greater difference in conformation between DNA- and RNA-protein in acrolein-polyester sections than between acrolein-treated free DNA and RNA in solution. This is supported by recent evidence that the conformation of ribosomal RNA is quite different in whole ribosomes from that assumed by the same RNA free in solution. The acrolein-polyester method may enhance color contrast by providing superior preservation of ordered nucleoprotein conformations.


Studies on purified C'1 esterase and hereditary angioneurotic oedema sera by combined electrophoresis and immune haemolysis.


The mannequin. A teaching aid in ophthalmology.


Inhibition by heparinoid of aldosterone biosynthesis in man.


Commentary on a proposed TSH reserve test.


Antibody active sites and immunoglobulin molecules. In order to obtain detailed information about the relationship between structure and function in antibody molecules, a method called affinity labeling has been devised to attach chemical labels specifically to amino acid residues in the active sites of antibody molecules. With antibodies to three different haptens, highly specific labeling of the active sites has been achieved. Tyrosine residues on both heavy and light polypeptide chains have been labeled in a molar ratio close to 2:1, and labels on the two chains are equally specific to the active sites. Peptide fragmentation studies of the labeled chains of one antibody system have shown that: (i) within 25 amino acid residues of the labeled tyrosine on either chain, substantial chemical heterogeneity exists among different antibody molecules of the same specificity; and (ii) the labeled peptide fragments from both chains are very similar in physicochemical characteristics, including average size, heterogeneity, and unusual hydrophobicity. These experimental results have led us to the view that a particular region of the heavy chain and a particular region of the light chain are utilized to construct the active sites of the three different antibodies, differences in specificity arising from chemical perturbations in these two regions. Correlated structural studies of affinity-labeled antibodies and of the homogeneous light chains (Bence Jones proteins) and heavy chains produced in multiple myeloma may permit the identification of these special active-site regions. The view that active sites of different specificity are chemical perturbations of a particular region of the antibody molecule has a possible close analogue in enzyme systems, particularly among the esterases. The marked chemical similarities we have observed between the active site regions of heavy and light chains indicate to us that chemical homologies, but not identities, exist between the chains. This is reinforced by recently obtained amino acid sequence data which reveal homologies between the two chains near their carboxyl-terminals. These results indicate that the structural genes which code for the synthesis of heavy and light chains are related, presumably having arisen from some common ancestral gene during evolution. This conclusion strongly suggests that both heavy and light chains determine antibody specificity, and has important implications for the still-unknow mechanisms of antibody biosynthesis.


Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture. Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.


10-Demethylation of testosterone by human prostate, in vitro.


The role of calcium and magnesium ions in invasiveness of schistosome cercariae.


Intestinal lipodystrophy (Whipple's disease): a cause of unexplained fever.


The immunoglobulins in congenital rubella.


Cardiopulmonary effects of tobacco and related substances. I. The release of histamine during inhalation of cigarette smoke and anoxemia in the heart-lung and intact dog preparation.


A mammalian equivalent of the avian bursa of Fabricius.


Liver function after myocardial infarction.


Effect of urinary pH on excretion of porphyrins.


Steroid therapy and strongyloidiasis.

Steroid therapy and strongyloidiasis.


Clinical recognition of hypoxaemia under fluorescent lamps.


Spontaneous descent of the testicle.

Spontaneous descent of the testicle.


Osteomalacia after gastrectomy.

Osteomalacia after gastrectomy.


Thymus and bursa.

Thymus and bursa.


A press-stud electrode for continuous monitoring of the electrocardiogram.


Air pollution and respiratory infection in children.


Third thoughts.

Third thoughts.


B.C.G., U.S.A.

B.C.G., U.S.A.


Brucellosis in East Africa.

Brucellosis in East Africa.


A success story.

A success story.


Regional lymph-nodes in malignant melanoma.


Staffing of clinical biochemistry laboratories serving the National Health Service.


The teaching potential of a home-care unit.


Lactate in cerebrospinal fluid during muscular exercise.


Lactate in cerebrospinal fluid during hyperventilation.


Excitatory and depressive phenomena in the olfactory system of the sloth (Choloepus hoffmani Peters).


Hydroxytryptaminergic transmission in a frog vagus-stomach muscle preparation.


Hypothalamic control of coronary circulation in the dog.


Changes of aspartic acid in various cerebral structures of hibernating and aroused ground squirrels.


Cortical activation of pyramidal tract during the sleepwakefulness cycle.


Thalamic transmission changes during the rapid eye movements of deep sleep.


The effect of intracarotid amobarbital injections upon experimentally induced epileptiform activity.


Electrical stimulation of therapeutic targets in waking dyskinetic patients.


Post-primary cortical responses to flashes and their specific potentiation by steady light.


An analysis of cingulate gyrus response to cingulum stimulation in the cat.


The volume conduction of motor unit potentials.


Infrared thermograph studies of cortical circulation: evaluation of the method.


A method for attaching apparatus to the skull.


Estrogenic management of benign prostatism, including early and poor-risk cases. 7-year experience.


Biosynthesis of gamma globulin: studies in a cell-free system. Incorporation of C(14)-amino acids into high-molecular-weight material precipitable by trichloroacetic acid indicates that microsomal cell-free systems, derived from spleens of immunized rabbits, are active in protein synthesis. Protein was made soluble by ultrasonic irradiation of the cell-free incubation mixtures, and low-molecular-weight materials were removed by dialysis and gel filtration. Chromatography and radio-immunoelectrophoresis of this soluble protein fraction reveal C(14)-labeled protein having several characteristics of gamma globulin.


Hepatic synthesis of alpha 2 (acute phase)-globulin of rat plasma. Synthesis of plasma alpha(2) (acute phase)-globulin was demonstrated in isolated perfused rat liver obtained from animals showing acute inflammatory reaction to injury. These findings indicate that the liver is a source of the globulin and that appearance of this protein in the serum results from de novo synthesis by the liver rather than from release of performed and stored globulin.


Sensitivity to P-T-C among primates.

Sensitivity to P-T-C among primates.


Innovations in the teaching of anatomy.

Innovations in the teaching of anatomy.


Biomedical communication: crisis and plan for action.


The synthesis of foetal chicks and rats of serum proteins having some properties of the immunoglobulins.


The effect of heparin on nuclear immunofluorescence.


A simple model for the in-vivo function of antibody.


Growth of diploid and heteroploid tissue cultures in the presence of some antibiotics.


Proteolysis of fluoresceinated proteins.


Production of gamma-1- and gamma-2-antiovalbumin by various lymphoid tissues of the guinea pig.


A study of soluble complexes and uncombined material in antigen-antibody reactions involving allotypic specificities of purified rabbit gamma-globulin.


Components of fraction 3 and pepsin-digested fraction 3 from papain-digested rabbit gamma-globulin.


Reaginic activity associated with IgG immunoglobulin. Five human sera with reaginic activity to a number of allergens were fractionated using anion exchange chromatography. In each serum, fractions which contained detectable IgG and no detectable IgA had capacity to fix to skin and subsequently elicit a P-K reaction. Four of these sera had reaginic activity about equally distributed between fractions containing only IgG and fractions containing mixtures of IgG and IgA. A fifth serum contained reaginic activity to crystalline bovine serum albumin (BSA) and most of the activity was associated with the fraction which contained only IgG. This serum was extensively studied using a variety of techniques and it was confirmed that most of the reagin to BSA in this serum was in those fractions containing only IgG. Since reaginic activity can no longer be considered a unique property of IgA the implications of finding antibody with reaginic qualities in immunoglobulins other than IgA are discussed.


Transformation products of 5H-dibenzo-[a,d]-10,11-dihydrocyclohepten-5-one.


Gamma-A-blood group antibodies.

Gamma-A-blood group antibodies. The serological characteristics of gammaA-anti-A and anti-B were studied using, as a source, either colostrum, or fractions relatively rich in gammaA obtained from selected potent antisera. gammaA-anti-A and anti-B were never hemolytic nor did they sensitize red cells to agglutination by anticomplement globulin sera. gammaA-anti-A, like gammaG-anti-A and unlike gammaM-anti-A was unaffected by heating at 56 degrees C for 3 hr. On the other hand in the following three characteristics the behavior of gammaA fell between that of gammaG- or gammaM-anti-A: sensitivity to inactivation by 2-mercaptoethanol, ease of neutralization by A substance and degree of enhancement of agglutination in a medium of serum rather than saline. The agglutination produced by gammaA-anti-A was regularly enhanced by addition of anti-gammaA-globulin serum. In searching for gammaA-blood group antibodies of other specificities the following sera were tested: anti-D (32 examples); anti-c (2 examples); anti-Le(a) or -Le(b) (3 examples); anti-K (3 examples); anti-Fy(a) (3 examples), and anti-Jk(a) (3 examples). Only 3 sera, all containing anti-D, sensitized red cells to agglutination by anti-gammaA. There were no discrepancies between results obtained with four different anti-gammaA-globulin sera. Approximately half the sera were fractionated on DEAE-cellulose, and the fractions rich in gammaA tested for their ability to sensitize red cells to agglutination by anti-gammaA; no additional examples of gammaA-antibodies were detected. One of the three examples of gammaA-anti-D appeared in the serum of a woman during the course of deliberate reimmunization. gammaA-anti-D appeared only after three intravenous injections of red cells although the gammaG-anti-D titer rose considerably after a single injection. 3 yr after a fourth injection of Rh-positive cells gammaA-anti-D, as well as gammaG-anti-D, was still present in the serum.


Chromosomes in Kostmann's disease.

Chromosomes in Kostmann's disease.


Karyotype of treated thrombocythemia.

Karyotype of treated thrombocythemia.


Deleted late-replicating chromosomes.

Deleted late-replicating chromosomes.


Pulmonary veno-occlusive disease.

Pulmonary veno-occlusive disease.


Sex chromatin after cytostatic drugs.

Sex chromatin after cytostatic drugs.


The bleeding disorder of uraemia. A qualitative platelet defect.


Chromosome studies on testicular cells from 50 subfertile men.


Idiopathic haemochromatosis in a family.


Pulmonary complications of peritoneal dialysis.


Intermittent therapy with corticotrophin.


Phosphaturic effect of thyrocalcitonin.

Phosphaturic effect of thyrocalcitonin.


Renal clearance of 57-Co-cyanocobalamin. Importance of plasma-protein binding.


Rhesus-immunised mothers and direct-coombs-test-negative babies.


Intrinsic -factor antibodies in gastric juice of pernicious - anemia patients.


Serum-growth-hormone in acromegaly. Effect of cryogenic pituitary destruction.


The Aldon intestinal deflation tube.

The Aldon intestinal deflation tube.


Training of pathologists.

Training of pathologists.


The geography of multiple sclerosis.

The geography of multiple sclerosis.


Diagnosis of renovascular hypertension.

Diagnosis of renovascular hypertension.


Management, during dental surgery, of patients on anticoagulants.


Use of potassium permanganate as a fixative for virus particles in plant tissues.


Clinical observations on prostatic hypertrophy of 268 cases in the recent 15 years.


Staining of the thyroid gland with ferritin-conjugated antithyroglobulin.


Polypeptide chain structure of rabbit immunoglobulins. I. gamma-G-immunoglobulin.


Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin, mithramycin, and olivomycin).


Aggregation of IgG globulin in vivo. II. Physicochemical properties of the isolated protein.


Polypeptide chain structure of rabbit immunoglobulins. II. gamma-M-immunoglobulin.


Observations on the lipolytic action in vitro of a fat-mobilizing substance extracted from urine of fasting rats.


Factors influencing the excretion of a fat-mobilizing substance in the urine of rats.


Jejunal bacteriology and bile-salt metabolism in patients with intestinal malabsorption.


Transferable R factors in enteric bacteria causing infection of the genitourinary tract.


Mortality in neonatal duodenal obstruction.


Reflections on cardiopulmonary resuscitation.


Extra minute chromosome in somatic and germ-line cells of the same person.


Ambilhar in amoebic dysentery and amoebic liver abscess.


Effect of secretin on insulin secretion.


Effects of secretin on insulin and glucagon in portal and peripheral blood in man.


Rubidomycin. A new agent active in the treatment of acute lymphoblastic leukaemia.


Kuru as a persisting tolerated infection.


Cancer research: is progress too slow?

Cancer research: is progress too slow?


Vein tester and stretcher.

Vein tester and stretcher.


Toxicity of tannic acid.

Toxicity of tannic acid.


Intestinal hormones and insulin.

Intestinal hormones and insulin.


Congenital word blindness.

Congenital word blindness.


Injection accidents in industry.

Injection accidents in industry.


Control of smallpox.

Control of smallpox.


B.M.A'S views on abortion.

B.M.A'S views on abortion.


The first fourteen days of some west African babies.


Pathological fracture.

Pathological fracture.


Dissociation of delayed-hypersensitivy and antibody-synthesising capacities in man. Report of two sibships with thymic dysplasia, lymphoid tissue depletion, and normal immunoglobulins.


Haemodynamic effects of physical training in coronary patients.


The normal synthesis, catabolism, and distribution of albumin and gamma-globulin.


Pathophysiology of plasma proteins with special reference to hypoproteinaemic states.


The total clearance of different gammaglobulin preparations.


Precipitation methods and large-scale methods.


Isolation of gamma-A-globulin as by-product of large-scale fractionation.


Immunochemical determination of plasma proteins.


The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds.


Diseases of the heart and blood-vessels. Ischaemia of the lower limbs.


Thyrotoxicosis, hyperparathyroidism, and hyperuricaemia.


The relation of covert cognitive interference in the color-phonetic symbol test to personality characteristics and adjustment.


The cell web in the ameloblasts of the rat incisor.


Demineralization with EDTA by constant replacement.


Ultraviolet fluorescence of bladder tumors following oral administration of tetracycline compounds. A macroscopic, microscopic and fluorescence spectrophotometric study.


Cytology and histopathology of cervical herpes simplex infection.


Effects of antitumor agents and hyperbaric oxygen in normal and tumor-bearing rodents.


Comparative histochemical studies of L-leucyl beta-naphthylamidase in ovarian epithelial tumors.


Histochemical study of the enzymatic activity of human neoplasms. 3. Structural-functional relationships in a hepatoma.


Histochemical study of the enzymatic activity of human neoplasms. II. Histogenesis of renal cell carcinoma.


Studies on diazabenzobicyclo[3.3.1]nonane system. IV. Synthesis of 1,2,3,4,5,6,-hexahydro-1,5-methanobenzo[e][1,3]diazocine derivatives.


Prednisone in emergency treatment of malignant exophthalmos.


Chromosomal abnormalities in idiopathic osteoarthropathy.


A comparison of tetracycline fluorescence and exfoliative cytology in the detection of malignancy.


Collagenolytic activity of the skin associated with neuromuscular diseases including amyotrophic lateral sclerosis.


Chemical test for bilirubin in liquor amnii. For assessment of prognosis in rhesus isoimmunisation.


The management of dry skin in leprosy patients.


Job's Syndrome. Recurrent, "cold", staphylococcal abscesses.


Loss of ejaculation in male rhesus monkeys after administration of progesterone to their female partners.


The third type of nucleic-acid-directed protein synthesis.


Muscle spindles.

Muscle spindles.


The lymphocyte.

The lymphocyte.


Oropharyngeal cancer in India.

Oropharyngeal cancer in India.


Greenwich district hospital.

Greenwich district hospital.


Effect of oral streptokinase on antibody and antiplasmin levels.


Effects of a gastrin-like pentapeptide (I.C.I. 50,123) on stomach and pancreas.


The effect of a synthetic gastrin-like pentapeptide (I.C.I. 50,123) on intestinal motility in man.


Circulatory effects of a synthetic gastrin-like pentapeptide (I.C.I. 50,123).


Mathematics and creative thinking.

Mathematics and creative thinking.


Microfluorometric characterization of intracellular nucleic acids and nucleoproteins by acridine orange.


Further studies of learning and memory after intracerebral actinomycin-D.


Cause of raised serum-alkaline-phosphatase after partial gastrectomy and in other malabsorption states.


Methods for teaching basic rehabilitation techniques to nonprofessional staff.


Proteus: the quiet sort.

Proteus: the quiet sort.


Female carriers of muscular dystrophy.

Female carriers of muscular dystrophy.


Contribution to the morphological study of dendritic arborization in the brain stem.


Immunoelectrophoretic study of serum proteins in mongolism.


Formation of complexes between basic proteins of leucocytes and plasma globulins.


Staining of blood smears. 7.

Staining of blood smears. 7.


Cytochemical localization of pancreatic lipase with light and electron microscopy.


Immuno-diazothioether-osmium tetroxide (immuno-DTO) technique for staining embedded antigen in electron microscopy.


Post-embedding staining for electron microscopy with ferritin-antibody conjugates.


Formation of vaccinia antigen studied by immunouranium and immuno-diazothioether-osmium tetroxide techniques.


Selectivity of ferritin-protein conjugates for sites on skeletal muscle.


Tryptic digestion of rabbit gamma-globulin.


A light scattering technique for measuring protein concentration.


Immunoglobulin M allotypes of the rabbit: identification of a second specificity. Rabbit antiserums, originally prepared to react specifically with rabbit immunoglobulin allotypes Ab5 and Ab6, also react with some normal rabbit serums that clearly do not contain Ab5 or Ab6 allotypes. This reaction is due to antigenic specificity present on rabbit immunoglobulin M(IgM) and not on rabbit immunoglobulin G. Serums that contain this IgM allotype do not react with an antiserum that reacts with the known rabbit IgM allotype, Ms1. This specificity may therefore be identified as a second rabbit IgM allotype, Ms2.


Subclasses of human immunoglobulin a based on differences in the alpha polypeptide chains. Antiserum from goats immunized with heavy polypeptide chains from a gammaA-type myeloma globulin was absorbed with serum from patients with selective absence of immunoglobulin A (gammaA). The resulting reagents could be used for the classification of 58 gammaA-myeloma proteins into two distinct antigenic types, respectively called subclasses He and Le. These differences were shown to be related to the heavy (alpha) polypeptide chains and independent of the integrity of interchain disulfide bridges. The gammaA-immunoglobulin from normal serum appears to consist, for the most part, of molecules with Le subclass specificity.


Urinary gamma-globulin excretion in systemic lupus erythematosus.


A study of in vitro incorporation of tetracycline antibiotics into avian and mammalian blood cells.


5'-Nucleotidase activity in human blood granulocytes during acute infections.


Negative staining of ultrathin secretion.


Towards responsible parenthood. The education of the educators.


Slowing of cerebral circulation after concussional head injury. A controlled trial.


Postoperative changes in gas tensions of arterial blood and in ventilatory function.


Frequency-distribution curve of uric acid in the general population.


Effects of cigarette smoking on serum-lipids, blood-glucose, and platelet adhesiveness.


Absence of prophylactic effect of linolenic acid in patients with coronary heart-disease.


Gastric acid secretion in chronic iron-deficiency anaemia.


Phenylketonuria among the mentally retarded in India.


The triphenyl tetrazolium chloride test in general-practitioner antenatal care.


Solitary pyogenic liver abscess in patients with diabetes mellitus.


Temperature control in incubators.

Temperature control in incubators.


Calcium, phosphorus, and fatty acids in plasma stored at room temperature.


Heterogeneity of lymphocytes in chronic lymphocytic leukaemia.


Experimental homotransplantation of the knee-joint.


Decreasing alveolar size from apex to base in the upright lung.


Experimental cholera. A canine model.

Experimental cholera. A canine model.


Postoperative hypoxaemia.

Postoperative hypoxaemia.


Epidemics of acute leukaemia.

Epidemics of acute leukaemia.


Survival of children with nephroblastoma.


Overdoses from linear accelerator.

Overdoses from linear accelerator.


Milk-borne diseases. An epidemiological review.


Measurement of gastric emptying-rate.

Measurement of gastric emptying-rate.


Long marker chromosome in bronchogenic carcinoma.


Chromosomes in chronic lymphocytic leukaemia.


Chromosomes in cleft-palate tissues.

Chromosomes in cleft-palate tissues.


Serum-vitamin-B12 and chlorpromazine.

Serum-vitamin-B12 and chlorpromazine.


Mitogenic action of trypsin and chymotrypsin.


Canine mastocytoma: altered alpha-globulin distribution.


WHO-supported comparative studies of attenuated live measles virus vaccines. UNDER THE AUSPICES OF WHO A COMPARATIVE STUDY OF ATTENUATED LIVE MEASLES VACCINES WAS MADE BY TEAMS IN FIVE COUNTRIES: Canada, Czechoslovakia, Nigeria, Switzerland and Yugoslavia. The reactions and antibody responses to Enders' Edmonston B vaccine with or without gamma-globulin and to the Schwarz, Beckenham and Milovanović vaccine were measured. In each trial Enders' Edmonston B vaccine with gamma-globulin was used as a "standard" vaccine, and in each trial there was also an unvaccinated control group. There were altogether 1685 children in the study-1317 vaccinated and 368 controls.Each team placed the vaccines in a similar order as to the percentages of children with rash and pyrexia after vaccination. The percentages of children with rash and pyrexia after injection of the same vaccine were, however, found to vary greatly between trials. It was therefore impossible to give accurate figures for the percentage of children who would develop pyrexia after any one vaccine, but in general terms the proportion of children with fever of 39.4 degrees C (103 degrees F) or more may be expected to vary from 10% to 30% depending on the vaccine used. Six of the vaccinated children (0.5%) had convulsions 6-9 days after vaccination, but no other serious reactions and no permanent sequelae were recorded. No convulsions occurred in the unvaccinated control groups. The antibody responses were measured by the haemagglutination-inhibition test; nearly all children gave an antibody response but this varied with the vaccine employed. Children given vaccines causing the most reaction had the highest antibody levels.


Immunochemical semiquantitative estimation of gamma-M- and gamma-A-immunoglobulins in healthy and diseased children. 3. Immunoglobulin levels in infectious diseases, allergic diseases, collagen diseases and liver cirrhosis.


Placental transmission of autoimmune diseases.


Ligation of the main pulmonary artery and systemic-pulmonary arterial anastomosis. A new palliative operation for complete transposition of the great arteries.


Intracellular potentials from "idle" cells in cerebral cortex of cat.


Evoked potentials and reaction times: a study of intra-individual variability.


Prevalence of hallux valgus in a neolithic New Guinea population.


Oral contraceptives and thyroid function tests.


Cytochemical localization of lactate dehydrogenase in muscular dystrophy of the mouse. By use of phenazine methosulfate and the "ncubation mixture film method," lactate dehydrogenase activity has been demonstrated in the dystrophic muscle fibers of strain 129 mice. The results indicate that for demonstration of lactate dehydrogenase activity in dystrophic muscle fibers phenazine methosulfate is necessary. This finding is typical for the "white" muscle fibers in the normal muscle and suggests that the dystrophy affects primarily the "white" muscle fibers.


Specificity in the combination of Fd fragments with L chains to form hapten-binding sites. In the work reported here we have shown that light chains and Fd fragments can be separated completely in propionic acid and then recombined to form Fab fragments with antibody activity. This experiment indicates that in the recombination a correct alignment of the Fd fragments and the L chains occurs to give a competent antibody site, just as occurs with the recombination of separated heavy and light chains of the antibody; thus the Fc fragment is not required for correct alignment. Fd fragments of antibody alone show very low binding activity toward the specific hapten. As is the case for the combination of heavy and light chains, the combination of Fd fragments and light chains also requires that both components come from antibody from the same rabbit in order to give binding sites. When they are derived from different rabbits producing antibody against the same antigen, they still give Fab fragments as shown by immunoelectrophoresis but do not have competent binding sites. An important observation is that the subunits of the papain digest fractions, Fab(I) and Fab(II), have the capacity to cross-combine to form active Fab fragments with competent binding sites. Fd(I) from Fab(I) combines with L(II) chains from Fab(II) to give the composite (Fd(I)-L(II)) with good binding activity. Likewise, the composite (Fd(II)-L(I)) has good binding activity. The composites from the two types of antibody molecules yielding different Fab fragments have antibody activity although heretofore these molecules have appeared to be different on the bases of chromatography and amino acid analysis. There is also a preferential combination of the Fd fragments to combine with the correct L fragments to give binding sites since this combination takes preference over the combination of Fd fragments of antibody with light chains of normal globulin (or of light chains of antibody with Fd fragments of normal globulin).


Relationship of some vibrio antibodies to serum immune globulins in man and in Cercopithecus aethiops.


Is our pathology really necessary? Parkinson versus Beeching.


Myeloma cells and immunoglobulin formation.


The politics of pollution.

The politics of pollution.


Endocrine studies in African males with nasopharyngeal cancer.


Fatal granulomatous disease of childhood. An inborn abnormality of phagocytic function.


The excretion of foriminoglutamic acid and urocanic acid after partial gastrectomy.


Urinary insulin excretion in healthy children and in siblings of childhood-onset diabetics.


The deconjugation of bile salts by human intestinal bacteria.


Effect of thalidomide on survival of skin homografts in rabbits.


Therapeutic suggestion. An important part of hypnotic medication.


A method of continuous measurement of arterial-oxygen tension.


Measurement of rate of gastric emptying using chromium-51.


The mechanism of acidosis caused by infusion of saline solution.


Mechanism of water and electrolyte secretion by the eccrine sweat gland.


Modification of Down's ileostomy appliance.


Man in the control room.

Man in the control room.


Family likeness.

Family likeness.


Maternal deaths.

Maternal deaths.


Effects of radiation from fallout.

Effects of radiation from fallout.


Family planning and the physician.

Family planning and the physician.


Urine pH and drug excretion.

Urine pH and drug excretion.


Another chance for thalidomide?

Another chance for thalidomide?


The "loss of control" myth.

The "loss of control" myth.


P.HA. and thymic lymphocytes.

P.HA. and thymic lymphocytes.


Phytohaemagglutinin and lymphocytes from acute lymphocytic leukaemia.


Pulmonary blood-flow in lung cancer.

Pulmonary blood-flow in lung cancer.


Methyldopa and haemolytic anaemia.

Methyldopa and haemolytic anaemia.


Gonadal dysgenesis and diabetes.

Gonadal dysgenesis and diabetes.


Histamine metabolism in carcinoidosis.

Histamine metabolism in carcinoidosis.


Enzymes in trisomy-18 syndrome.

Enzymes in trisomy-18 syndrome.


Mosaicism of X and G chromosomes.

Mosaicism of X and G chromosomes.


Metabolic changes after exercise.

Metabolic changes after exercise.


The electrocardiogram of neonatal hypoventilation.


Serum protein formation of donor type in rat-into-mouse chimaeras.


Properties of horse serum gamma inhibitor.


Creatine phosphokinase isoenzymes.

Creatine phosphokinase isoenzymes.


Use of galactose oxidase in the histochemical examination of mucus-secreting cells.


Effect of trypsin inhibitor isolated from sows' colostrum on the absorption of gamma-globulin by piglets.


Effect of dihydrostreptomycin on tissue lipid of guinea-pigs.


The influence of a heparin-like compound on hypertension, electrolytes and aldosterone in man.


Cystathioninuria from pyridoxine deficiency complicating treatment of hypercalcaemia in a cretin.


The effects of crude and purified gastrin preparations on the release of histamine from mast cells.


Appearance of rat slow alpha-2 globulin after irradiation.


The investigation of the immunological reactivity of patients with haemoblastosis.


"Yellow fat" in the wild rabbit.

"Yellow fat" in the wild rabbit.


High antihaemophilic factor in multiple myeloma.


Indications of the presence of organochlorine insecticides in rainwater in central England.


Use of methylene blue for staining sialomucoproteins on paper.


Fluorescent antibody studies in pemphigus vulgaris.


Clinical significance of autoantibodies in pemphigus.


Studies in immunoglobulin chemistry. I. Reinvestigation of the C-terminal amino acids of 6.5S rabbit and human gamma-globulins.


(S)- and (R)-1-cyano-2-hydroxy-3-butene from myrosinase hydrolysis of epi-progoitrin and progoitrin.


The value of continuous saline rinses in mucoperiosteal flap surgery.


A modified Papanicolaou method for distinguishing degrees of keratinization in the oral mucosa using frozen tissues.


Histochemical study of acid phosphatase activity in cerebral tumors.


Vascular changes in senile brains. A micro-angiographic study.


Deposition of glycogen during the degeneration and regeneration of the sciatic nerves of rabbits. (Light and electron microscopic studies).


Solubility of proteins in the presence of polysaccharides.


The intramuscular nerve endings in muscular dystrophy. A biopsy study.


A study of the evolution of viral infection in experimental herpes simplex encephalitis and rabies by means of fluorescent antibody.


A staining method for proteins and dextrans on cellulose acetate.


Dependence of the chemical nature of antibodies on the net electrical charge of antigens.


Cytochemical demonstration of histones and protamines. Mechanism and specificity of the alkaline bromphenol blue binding reaction.


Fluorescence and viability of Proteus mirabilis stained directly with fluorescein isothiocyanate. Grunberg, E. (Hoffman-La Roche, Inc., Nutley, N.J.), and R. Cleeland. Fluorescence and viability of Proteus mirabilis stained directly with fluorescein isothiocyanate. J. Bacteriol. 92:23-27. 1966.-Washed cell suspensions of Proteus mirabilis, under the proper conditions, stained well with fluorescein isothiocyanate with little or no loss of cell viability. The speed and intensity of the reaction was dependent on both the concentration of dye and pH. Within a range of pH 3.0 to 10.0, staining was most rapid at pH 5.0 to 6.0, with a slower and less intense reaction occurring at the other pH values. As the concentration of dye at either pH 5.0 or 9.0 was increased from 10 to 1,000 mug/ml, there was an increase in the rate of staining but a decrease in cell viability. After 24 hr of incubation at 4 C, pH 5.0, and a dye concentration of 10 mug/ml, all cells were stained, the majority exhibiting intense fluorescence with little or no loss of viability noted. In preliminary experiments with Staphylococcus aureus, similar results were obtained. Of various other fluorescent dyes tested, only rhodamine isothiocyanate was found to give satisfactory staining.


Lymphochromography in female pelvic cavity.


Electrophoretic and immunoelectrophoretic studies of sera from normal, tuberculous, and noninfected tuberculin-sensitive guinea pigs. Dardas, T. J. (Michigan State University, East Lansing), and V. H. Mallmann. Electrophoretic and immunoelectrophoretic studies of sera from normal, tuberculous, and noninfected tuberculin-sensitive guinea pigs. J. Bacteriol. 92:76-81. 1966.-Normal guinea pig serum was separated into seven fractions by electrophoresis on cellulose acetate membranes. Thirty antigens were found by immunoelectrophoresis: albumin, 6 alpha(1) globulins, 11 alpha(2) globulins, 6 beta(1) globulins, 5 beta(2) globulins, and gamma globulin. Hyper-alpha(2)-globulinemia was detected in sera from guinea pigs 14 days after inoculation with viable virulent Mycobacterium bovis. An additional alpha(2) globulin, not demonstrable prior to infection, was detected concomitantly with the hyper-alpha(2)-globulinemia by immunoelectrophoresis. The additional alpha(2) globulin was tentatively named alpha(2)-T. It persisted until the death of the guinea pigs. Neither hyper-alpha-globulinemia nor the alpha(2)-T antigen was detected by cellulose acetate electrophoresis and immunoelectrophoresis of sera from guinea pigs sensitized with heat-killed M. bovis. Both changes were due to the disease, not to delayed sensitivity alone.


Side effects of treatment of hypogammaglobulinaemia with gammaglobulin.


Mode of action of certain myelin stains.


The clinical manifestations of temporal arteritis.


Anaphylaxis in the cat.

Anaphylaxis in the cat.


Gamma globulin catabolism by the kidney.


Gastrointestinal motility function related to thyroid activity. An experimental study in the rat.


The ultrastructural basis for the identification of cell types in the pancreatic islets. I. Guinea pig.


The cultured lymphocytes of atopic patients.


Immunologic responses and "altered reactivity" in syphilis.


Studies on human antibodies. IV. Purification and properties of anti-A and anti-B obtained by absorption and elution from insoluble blood group substances. Insoluble blood group substances prepared by copolymerization of soluble blood group substances with N-carboxy-L-leucine anhydride were used to absorb blood group antibodies from two human, high-titered anti-A sera. After the absorbants were washed free of nonspecific serum proteins, blood group antibodies were eluted either with pH 3.62 acetate buffer, or at neutral pH with monosaccharide haptens of the A or B antigenic determinants (N-acetyl-D-galactosamine or D-galactose respectively). The purified anti-A antibodies were characterized, immunoelectrophoretically, as gammaM-, gammaA-, and gammaG-immunoglobulins. These were further separated into gammaM- and gammaG-fractions by gel filtration or density gradient centrifugation. Both gammaM- and one of the two gammaG-antibody fractions contained K and L light chain determinants; the remaining gammaG-fraction was comprised, almost totally, of type K molecules. Precipitability of the purified anti-A immunoglobulins by blood group A substance varied from 43 to 89%. The agglutinating activity per unit N of the isolated gammaG-anti-A was found to equal, in one case, and to exceed, in the second, that of the gammaM-antibodies from the same individuals. The marked differences between gammaM- and gammaG-antibody fractions in quantitative hapten inhibition studies were interpreted to mean that the antibody-combining site of the isolated eluted gammaG-anti-A was significantly larger than that of the eluted gammaM-anti-A. Whether these data connote differences in combining site size between entire immunoglobulin classes in an individual serum or simply reflect the properties of highly selected antibody populations cannot be stated at present.


Studies on immunoglobulins of Nigerians. II. Immunoglobulins and malarial infection in Nigerians.


Studies on immunoglobulins of Nigerians. I. The immunoglobulin levels of a Nigerian population.


The in vivo formation and fate of antigen-antibody complexes formed by fragments and polypeptide chains of rabbit gamma-G-antibodies. The in vivo formation and subsequent fate of complexes formed between specific rabbit gammaG-antibody subunits and circulating protein antigens was studied in rabbits and guinea pigs. Subunits obtained from purified antibodies were injected immediately after an injection of antigen, and the elimination from the circulation of either I*-labeled gammaG-subunits or labeled antigen determined. In the absence of antigen, all gammaG-subunits which lack the Fc fragment were rapidly eliminated. In the presence of excess antigen, F (ab')(2), Fab and Fd fragments reacted with antigen and remained in the circulation as complexes which were eliminated at the same rate as the antigen. Fab hybrids containing a specific Fd fragment and a nonspecific L chain similarly reacted with antigen and remained in the circulation complexed to antigen. In contrast, L chains and Fab hybrids containing a specific L chain and a nonspecific Fd fragment did not react with antigen in vivo and were rapidly eliminated in both presence and absence of antigen. H chains remained in the circulation of rabbits in the absence of antigen, however, in the presence of antigen, more H chains which formed complexes with antigen remained in the intravascular space and were rapidly eliminated when the immune elimination of the antigen by the host occurred. Nonspecific H chains were rapidly eliminated from the circulaion of guinea pigs, whereas specific H chains remained in the circulation with the antigen. F (ab')(2) fragments formed complexes with antigen near antibody equivalence and in antibody excess which were rapidly eliminated, however, less effectively than complexes formed near antibody equivalence with intact gammaG. Complexes formed in antibody excess between Fab fragments and H chains remained in the circulation at all concentrations studied and were eliminated at the rate of antigen. The role of the Fc fragment in the immune elimination of antigen-antibody complexes is discussed.


Individuality of glycoproteins in human aorta.


Relations between EEG phenomena and potentials of single cortical cells. II. Spontaneous and convulsoid activity.


Relations between EEG phenomena and potentials of single cortical cells. I. Evoked responses after thalamic and erpicortical stimulation.


Stable changes in the pattern of the recruiting response associated with a well established conditioned reflex.


Electroencephalography in subjects sixty years and over.


Thalamic spreading depression in the rat.


A neurophysiological comparison of alpha-chloralose with gamma-hydroxybutyrate in cats.


A power booster for stimulus isolation units.


An automatic drive for micro-electrodes.


Abnormal lymphocytes in schizophrenia.

Abnormal lymphocytes in schizophrenia.


Investigations into the mechanism of electroshock in the rat. II. Effect of electrical stimulation on the capillary endothelium and on hemodynamic conditions in histamine and serotonin-depleted rats.


Thymic lymphatics and the cellular localization of gamma globulin in the guinea pig thymus.


Damage to proteins, enzymes, and amino acids by peroxidizing lipids.


Size classes of soluble liver macromolecules.


Spectroscopic and staining studies of the ripening and overripening of aluminum hematoxylins.


A silver staining reaction for chromosomes and nuclei.


A colony of actinomyces-like organisms in a periapical granuloma.


Heterologous transplantation with Kiel bone. An experimental and clinical study.


An unusual late complication of pulmonary artery banding.


Physiochemical properties of reaginic antibody. II. Characteristic properties of reaginic antibody different from human gamma-A-isohemagglutinin and gamma-D-globulin.


The radiotherapy of carcinoma of the oesophagus and post cricoid region in south east Scotland.


Whipple's disease.

Whipple's disease.


The effect of thyroid hormone and an antithyroid drug on the startle response of the rat.


Nasal decongestants in otorhinolaryngology.


Physiologic evidence concerning the re-entry hypothesis for ectopic beats.


Infectious mononucleosis. Some observations on the cellular localization of immune globulin synthesis.


The diagnostic value of premature beats.


Effect of curarisation on breath-holding time.


Iodine-125-labelled L chains of human blood group antibodies.


Active anaphylactic reaction in mouse peritoneal mast cells in vitro.


Diagnosis and results of surgery in renovascular hypertension.


Serum-free-fatty-acids after acute myocardial infarction and cerebral vascular occlusion.


Hypoglycemia in children with acute diarrhoea.


Incidence of a positive direct coombs test in patients on alpha-methyldopa.


Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy.


Treatment of endotoxic shock with isoprenaline.


Functional compensation after small-bowel resection in man. Demonstration by direct measurement.


An application of the serological recognition of transplantation antigens on leucocytes.


Beryllium poisoning.

Beryllium poisoning.


Protein deficiencies and calorie deficiencies.


The effect of organic solvents on rabbit antibody.


Spontaneous peritonitis in cirrhosis of the liver.


Chemical evaluation of conformational differences in native and chemically modified proteins.


Ultraviolet reactivation of a bacteriophage containing a single-stranded deoxyribonucleic acid as a genetic element.


Interaction between poliovirus and immunoglobulins. 3. The effect of cleavage products of rabbit gamma-G-globulin on infectivity and distribution of virus in polymer phase systems.


Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications.


Direct fluorescent antibody studies of gamma globulin localization in muscle of patients with myasthenia gravis.


Ultrastructural localization of gamma globulin binding to skeletal muscle.


Studies in myasthenia gravis: demonstration of presence of immunofluorescence in serums correlated with clinical findings.


Does myasthenic serum bind to the neuromuscular junction?


Occurrence of two different rheumatoid factors reacting with immune and normal rabbit gamma-globulins.


1966 annual award. Presentation address.


Unit signs of visual cortex modulation by the lateral geniculate body.


Changes in visual recovery functions produced by temporal lobe stimulation in monkeys.


The natural history of isolated ventricular septal defects in infancy. Indication for palliative, surgical treatment.


Steady potential correlates of intracranial reinforcement.


Trypsin stabilizers in human serum. The role of alpha-2-macroglobulin.


The staining behavior of oocyte cytoplasm with the alcoholic Feulgen variant and with methyl green.


Prosatic massage and the plasma acid phosphatase level.


The effect of epsilon aminocaproic acid on the blood loss after retropubic prostatectomy.


Molecular genetics of avian proteins. VI. Evolutionary implications of blood proteins of eleven species of geese.


[Studies on examination methods with dyes for some biochemical functions of the cornea. Fluorescein test, methylene blue test and Evans blue test].


Acute rheumatic fever and carditis in older adults.


The simple assessment of selectivity in heavy proteinuria.


Effect of antisecretory drugs on gastric hypersecretion in endocrine-adenoma syndromes.


Effects of dextran 40 on postoperative renal haemodynamics.


Effect of a small decrease in blood-glucose on plasma-growth-hormone and urinary excretion of catecholamines in man.


The value of diuretics in respiratory failure.


Antibodies to cytoplasm of ova.

Antibodies to cytoplasm of ova.


Dicoumarol-induced diphenylhydantoin intoxication.


Anaesthesia during hypotensive therapy.

Anaesthesia during hypotensive therapy.


Exchange transfusion in anaemia.

Exchange transfusion in anaemia.


Autoimmunity to inflammatory exudates.

Autoimmunity to inflammatory exudates.


The medical officer of health.

The medical officer of health.


Hypertension and limb lengthening.

Hypertension and limb lengthening.


Towards the organisation of biochemistry in the general hospital.


Tetracyclines and the teeth.

Tetracyclines and the teeth.


Drug addiction.

Drug addiction.


Clinical evaluation of the blood smear.

Clinical evaluation of the blood smear.


A clinical and cytogenetical study of three patients with male phenotype and apparent XX sex chromosome constitution.


The N- and c-terminal amino acid sequences of the heavy chain from a pathological human immunoglobulin IgG. The heavy chain of a pathological human immunoglobulin IgG and also the Fd fragment have been isolated. No free alpha-amino group was present on either and the N-terminal sequence of both has been identified as pyrrolid-2-one-5-carbonylvalylthreonine. Splitting at the four methionine residues of the heavy chain with cyanogen bromide gave five fractions. The fraction from the C-terminal end of the chain was isolated in high yield and the amino acid sequence was: His-Glu-Ala-Leu-His-Asp(NH(2))-His-Tyr-Thr-Glu(NH(2))-Lys-Ser-Leu-Ser-Leu-Ser-Pro-Gly These results give strong support to the view that the heavy chain of immunoglobulin is a single peptide chain.


Immunological significance of the morphological changes in lymph nodes draining breast cancer.


Anaphylactic tests for tumour antigen in transplantable animal tumours.


A combined staining rack and slide washer.


The value of the plasma protein-bound iodine estimation in the diagnosis of primary myxoedema and thyrotoxicosis.


Thrombohemorrhagic lesions induced by combined treatment with rare earth metals and epinephrine.


A brief look at the management of hyperthyroidism.


Ageing of the human temporo mandibular disk with special reference to the occurrence of cartilaginous cells.


Insulin antibodies in pregnant guinea pigs and in their offspring.


Placental transfer of insulin-131-I in guinea pigs immunized against insulin.


The failure of gamma globulin as a prophylactic agent in meningococcal disease.


The synthesis of actinomycin analogues. II. Actinocylgramicidin S.


A clinical stain for use in selecting biopsy sites in patients with vulvar disease.


Evaluation of a new sequential contraceptive agent.


The feed-back mechanism in immunoglobulin synthesis.


Endometrial morphology after sequential medication with mestranol and chlormadinone.


Isolation of a reaginic antibody fraction with properties of gamma-g-globulin.


Separation of trypsin inhibitors of human plasma on DEAE-cellulose.


Isoimmunization with Human gamma-G immunoglobulins.


Quantitative studies on gamma-2 anti-dinitrophenyl antibodies.


Comparative development of pheasant and chick embryo sera.


Polarographic characteristics of human albumin, gamma globulin, ceruloplasmin and transferrin.


Amyloid staining with Thioflavine T in dermatopathology.


The immunoglobulins.

The immunoglobulins.


Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.


Immunoglobulins.

Immunoglobulins.


A comparison of the labile disulfide bonds of rabbit gamma-G-immunoglobulin fragments.


The metabolism of human gammaglobulin.

The metabolism of human gammaglobulin.


Examination for tubercle bacili by fluorescence microscopy.


The origin of yeasts from sputum.

The origin of yeasts from sputum.


Azophloxine GA, a selective stain for light and fluorescence microscopy of myoepithelial cells.


A pollen grain squash technique for Saccharum and related genera.


Fixation and staining of fungus hyphae and host plant root tissues for electron microscopy.


Calcium in cells of fresh bone stained with glyoxal bis(2-hydroxyanil).


Two-color fluorescent labeling of mineralizing tissues with tetracycline and 2,4-bis[N,N'-di-(carbomethyl)aminomethyl] fluorescein.


Flazo orange for masking of auto and nonspecific fluorescence of leukocytes and tissue cells.


Dysthyroid exophthalmos. Palliation by lateral orbital decompression.


Mucopolysaccharide staining in experimental corneal edema.


Modification of the homograft reaction in corneal transplantation. Further studies.


Liberal use of antibiotics and its effect in neonatal staphylococcal infection, with particular reference to erythromycin.


Immune response of man to inoculation with Plasmodium cynomolgi and challenge with P. vivax.


Use of silver-nitrate solutions in maintenance of air hygiene in a burns unit.


Bacteriuria in old age.

Bacteriuria in old age.


The normal thyroid scan.

The normal thyroid scan.


Toxic diffuse goitre in monozygotic twins.


Effects of micturition on leg reflexes.

Effects of micturition on leg reflexes.


pH studies in human malignant tumours.

pH studies in human malignant tumours.


Experimental autoimmune thymitis. An animal model of human myasthenia gravis.


Coaxial flow-guided catheterization of the pulmonary artery in transposition of the great arteries.


Erythropoiesis in chronic renal disease.


Renin and hypertension.

Renin and hypertension.


Hand-drill attachment for simplifying wire suturing of the sternum.


Parental deprivation and mental health.

Parental deprivation and mental health.


Arthrodesis, arthroplasty, or abduction osteotomy?


Obesity in childhood.

Obesity in childhood.


Fluorescent-antibody techniques in the diagnosis of syphilis.


Shortage of people.

Shortage of people.


Aetiology of reticuloses.

Aetiology of reticuloses.


Cleanliness.

Cleanliness.


Dopamine storage and parkinsonism.

Dopamine storage and parkinsonism.


Universities and government. The constant dialogue.


A safer system of supply and storage of medicines in hospitals.


Dietary factors associated with death-rates from certain neoplasms in man.


Laboratory suggestion. A simple staining unit for coverslips.


Presence of large numbers of plasma cells containing IgD in the rectal mucosa of a patient with ulcerative colitis.


Histochemical studies on acid mucopolysaccharides. I. On some new methods and differentiation in tissue sections.


Determination of gamma globulin in the cerebrospinal fluid by quantitative chromatography.


Immunoelectrophoretic studies in patients with cryofibrinogenemia.


Simple assessment of thyroid activity: the T3 resin sponge uptake test.


A scheme of care during pregnancy.

A scheme of care during pregnancy.


Low-temperature spectropolarimetry of protein solutions and the study of fast conformation changes in their molecules.


Clinical experience in homotransplantation of thyroid and parathyroid glands on vascular stumps.


Filling skeletal defects with thin plates of homogenous bone by the "faggot" method.


Congenital malformations of the auricle and their reconstruction by a new method.


Vehicle exhausts in relation to public health.


Method of covering gaping defects in the walls of the pharynx and cervical section of oesophagus after surgical removal of larynx.


Severe and extensive loss of skin on the limbs.


Staining of sectioned leptospirae with heavy metals.


Immunocytes and immunoglobulins.

Immunocytes and immunoglobulins.


Injection of rabbit anti-rat serum into rats presensitized with rabbit serum.


The distribution of immunoglobulin-containing cells along the human gastrointestinal tract.


"We are here to learn from one another".


Electrophoretic study of human isoamylases. A new saccharogenic staining method and preliminary results.


A challenge to APCA.

A challenge to APCA.


The seasonal, weekly, and daily cycles of atmospheric smoke content in central Montreal.


Electric car system introduced.

Electric car system introduced.


Symposium on current trends in peripheral vascular surgery. Acute venous occlusion.


Posterior root canal therapy. I.

Posterior root canal therapy. I.


Some serum protein polymorphisms in Kalahari bushmen and Bantu: gamma globulins, haptoglobins, and transferrins.


The plasma inorganic iodine concentration in thyrotoxicosis.


Serum immunoglobulins in rheumatoid arthritis.


Synergic effect of naturally occurring goitrogens on the thyroid gland in rats.


The effect of thyrotropic hormone in vivo on autoiodoproteolysis of 127-I-thyroglobulin in vitro.


Isoniazid plus thioacetazone compared with two regimens of isoniazid plus PAS in the domiciliary treatment of pulmonary tuberculosis in South Indian patients. Previous reports from the Tuberculosis Chemotherapy Centre, Madras, have established that ambulatory treatment of pulmonary tuberculosis with a standard daily regimen of isoniazid plus PAS for one year yields satisfactory results. However, this regimen may be unsuitable for large-scale use in many developing countries, because PAS is expensive, bulky and unpleasant to take, and has poor keeping qualities, especially in tropical countries. It might be possible to overcome these disadvantages, by substituting for the PAS a drug which is equally effective but less expensive and more acceptable, or by reducing the daily dosage of PAS and the period for which it is prescribed.This paper presents the results over a 12-month period of a controlled comparison of (a) the standard regimen of isoniazid (average 4.5 mg/kg body-weight) plus sodium PAS (average 0.22 g/kg), daily in two divided doses; (b) a regimen of isoniazid (average 6.9 mg/kg) plus thioacetazone (average 3.4 mg/kg), daily in one dose; and (c) a 2-phase regimen of isoniazid (average 5.5 mg/kg) plus sodium PAS (average 0.17 g/kg), daily in one dose for 6 months, followed by isoniazid alone (average 6.8 mg/kg), daily in one dose for the second 6 months. The regimen of isoniazid plus thioacetazone was found to be therapeutically as effective as the standard regimen of isoniazid plus PAS; however, it was associated with a higher incidence of minor side-effects, and three cases of exfoliative dermatitis. The 2-phase regimen of isoniazid plus PAS followed by isoniazid alone was less effective.These findings are encouraging for the large-scale use in developing countries of the relatively inexpensive regimen of isoniazid plus thioacetazone; however, any such step should be preceded by carefully planned studies to investigate, under local conditions, the toxicity and the efficacy of the regimen.


The chemical and histochemical properties of alcian blue. IV. Further studies on the methods for the identification of acid glycosaminoglycans.


Histone specificity revealed by ammoniacal silver staining.


New approaches to tetanus prophylaxis.

New approaches to tetanus prophylaxis.


Patterns of hormonal release after glucose, protein, and glucose plus protein.


Incidence and epidemicity of Down's syndrome.


Aortic-valve replacement.

Aortic-valve replacement.


The preparation of aortic-valve homografts.


Fatty foods and dyspersia.

Fatty foods and dyspersia.


Vesico-uretheral reflux and asymptomatic bacteriuria in the puerperium.


Lymphocyte cultures in drug hypersensitivity.


The use of double-wrapped packs to reduce contamination of the sterile contents during extraction.


Effect of a xanthine-oxidase inhibitor (allopurinol) on radioiron absorption in man.


Hyperphagia induced by ventricular pressure and pentobarbitone in normal and hypothalmic obese rats.


Clubbing  of the fingers and hypertropic osteoarthropathy in pregnancy.


X-Y chromosomal interchange in the aetiology of true hermaphroditism and of XX Klinefelter's syndrome.


Social security.

Social security.


A simple technique for continuous gastric aspiration.


Gastric ulcer and gastritis.

Gastric ulcer and gastritis.


Crumbling edifice.

Crumbling edifice.


A fresh look at protein-calorie malnutrition.


The second International Standard for Dihydrostreptomycin. The National Institute for Medical Research, London, was requested by the WHO Expert Committee on Biological Standardization to establish a second International Standard for Dihydrostreptomycin, since stocks of the first International Standard were depleted. A batch of 500 g of dihydrostreptomycin sulfate obtained in 1961 was distributed into ampoules in 200-mg amounts and dried in vacuo; the ampoules were then filled with dried nitrogen and sealed. The proposed replacement material has been assayed biologically in terms of the first International Standard in seven laboratories in six countries by means of both plate-diffusion and turbidimetric assays.Significant heterogeneity of the potencies obtained by the different laboratories was revealed by statistical analysis; this heterogeneity might be caused by slight differences in the content of streptomycin of the two samples. The material has been established as the Second International Standard for Dihydrostreptomycin with a defined potency of 820 IU/mg. The International Unit of Dihydrostreptomycin is defined as the activity of 0.001219 mg of the Second International Standard for Dihydrostreptomycin.


Further researches on transplantable tumours subjected to ionophoresis in vivo.


Some histochemical effects in the rat uterus submitted to ionophoresis in vivo.


Myringotomy in acute otitis media. A controlled study.


The pigmented hive.

The pigmented hive.


Effects of rheumatoid factor on complement levels in vivo.


Incidence and prediction of ischaemic heart-disease in London busmen.


A follow-up study of infants born to mothers with oestriol excretion during pregnancy.


Frequency of autoantibodies in patients with chromatin-positive Klinefelter's syndrome and their parents.


Effect of abdominal operation on glucose tolerance and serum levels of insulin, growth hormone, and hydrocortisone.


The role of erythrasma in pruritus ani.

The role of erythrasma in pruritus ani.


Effect of long-term corticosteroids and corticotrophin on the growth of children.


Gastrostomy in neonatal respiratory failure.


Transfusion-asociated viral hepatitis.

Transfusion-asociated viral hepatitis.


Sands of planning.

Sands of planning.


Assessment of lung function.

Assessment of lung function.


Treatment by local application of insulin of an infected wound in a diabetic.


Laboratory services for the general practitioner.


Insecticide residue in foods subjected to aerosols under simulated warehouse conditions.


Anti-gamma-globulin factors in visceral larva migrans.


The distribution of antigenic and nonantigenic compounds within draining lymph nodes.


Active and passive immunization of chimpanzees infected with West African and Southeast Asian strains of Plasmodium falciparum.


Comments on immunization.

Comments on immunization.


Radiological diagnosis of disaccharidase deficiency.


Fibrinolytic response to oral glucose.

Fibrinolytic response to oral glucose.


I-131 metabolism in whole and sliced rat thyroid lobes.


Manifestations of immunologic unresponsiveness in Hodgkin's disease.


Lymphoid malignancy and development, differentiation, and function of the lymphoreticular system.


Cytotoxic antibodies against leucocytes.


Late results of medical and surgical treatment of bleeding peptic ulcer.


Hashimoto's disease and encephalopathy.

Hashimoto's disease and encephalopathy.


Treatment of idiopathic secondary amenorrhoea with single injections of follicle-stimulating hormone and chorionic gonadotrophin.


Abdominal arterial murmurs in liver disease.


Hormone-excretion patterns in patients with dysmenorrhoea.


Blood-levels of hydrocortisone, transaminases, and cholesterol after myocardial infarction.


Adrenergic blockade and the eye signs of thyrotoxicosis.


Electron microscopy in the rapid diagnosis of smallpox.


The organisation of pharmacology.

The organisation of pharmacology.


Antidiuretic effect of diguanides.

Antidiuretic effect of diguanides.


Dental caries and the comforter.

Dental caries and the comforter.


Towards a numerate profession.

Towards a numerate profession.


Vitamin-A deficiency and blindness.

Vitamin-A deficiency and blindness.


Our problem too.

Our problem too.


Thrombophlebitis and pregnancy.

Thrombophlebitis and pregnancy.


The bleeding ulcer.

The bleeding ulcer.


"Only connect"...

"Only connect"...


Training as a consultant.

Training as a consultant.


Put the child to bed.

Put the child to bed.


Don't tell them...show them.

Don't tell them...show them.


In vitro selection and identification of antibiotic resistant Mycoplasma mutants.


Y chromosome and exclusion of paternity.


The influence of chronic infection on blood-pressure in New Guinea males.


A simple catheter for continuous intravascular sampling.


Unsuspected Wilms tumor. Dangers in the conservative therapy of renal trauma.


Reaction after administration of macroaggregated albumin for a lung scan.


Studies in a hyperthyroid subject after hypophysectomy.


The effect of chloral hydrate on bishydroxycoumarin metabolism; a fatal outcome.


Alterations in the values or tests of thyroid function in rabbits with immunologically produced thyroiditis.


Paediatrics 1984.

Paediatrics 1984.


Inherited thrombocytopenia.

Inherited thrombocytopenia.


Hashimoto's disease. A clinicopathological study with matched controls. Lack of significant associations with other "autoimmune" disorders.


Intra-arterial cytotoxic therapy and x-ray therapy for cancer of the head and neck.


Development of "autoimmune processes" in rabbits after neonatal removal of central lymphoid tissue.


Diabetes insipidus and obsessional neurosis. A syndrome.


Effect of desferrioxamine on iron absorption.


Contact dermatitis from neomycin and framycetin.


Immunoallergic lung purpura treated with azathioprine.


Mesenteric embolus treated with low-molecular-weight dextran.


Silicone foam resting splints for rheumatoid arthritis.


The part-time teacher.

The part-time teacher.


Warning device for oxygen cylinders.

Warning device for oxygen cylinders.


Tropical neurology.

Tropical neurology.


Health of immigrants.

Health of immigrants.


Results of respiratory-function tests in miners.


Corticosteroids in the acute infections.


A psychiatric mother and baby.

A psychiatric mother and baby.


Autosomal monosomy in a spontaneous abortion.


Mongolism and thyroid autoimmunity.

Mongolism and thyroid autoimmunity.


Parathion poisoning in Finland.

Parathion poisoning in Finland.


Partial excision of the vomer in infancy.


Plastic operations of abdominal wall.

Plastic operations of abdominal wall.


Observations on the treatment of burns in the tropics.


The nomenclature for cleft lip and/or palate.


Cleft uvula--a microform of cleft palate.


Middle ear mucosa.

Middle ear mucosa.


The present status of the caval-pulmonary anastomosis.


Cytoplasmic granules of the corneal stroma cell.


Effect of anabolic hormone on albumin and globulin turnover in aged patients.


Study on the effects of carbimazole therapy in heart diseases.


Delayed-type hypersensitivity and the immunology of Hodgkin's disease, with a parallel examination of sarcoidosis.


Hashimoto's disease. A search for associated disorders in 170 clinically detected cases.


Investigation of the occurrence of dermatophytes on the floor and in the air of indoor environments.


Circulating total serum-lipids in healthy and malnourished infants.


The mucoid cells of the adenohypophysis of the rabbit during pregnancy and lactation.


Studies of amniotic membranes.

Studies of amniotic membranes.


The proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity. 1. Proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity with papain and pepsin shortened the duration of thyroid stimulation in mice prepared for the McKenzie (1958) bioassay. The time-course appeared to be related to molecular size. 2. The activity after proteolysis was recovered solely in the electrophoretically slow F(ab)-fragment. 3. There was no immunological cross-reaction between pituitary thyroid-stimulating hormone and the active fragments of the long-acting thyroid stimulator despite their similar behaviour in the bioassay. 4. The implications of these findings are discussed.


Recovery of antigenic activity upon reoxidation of completely reduced polyalanyl rabbit immunoglobulin G.


Polysaccharides associated with the exterior surface of epithelial cells: kidney, intestine, brain.


Long-term arterial-graft patency in relation to platelet adhesiveness, biochemical factors, and anticoagulant therapy.


Complement-dependent biological functions in complement deficiency in man.


A simple technique for measuring changes in ventilatory response to carbon dioxide.


Attempted adoptive immunotherapy of acute leukaemia by leucocyte transfusions.


Acid-base status of amniotic fluid during delivery.


Pathological changes in the nervous system in severe neonatal hypoglycaemia.


The complement system and body defence.

The complement system and body defence.


Infected meat.

Infected meat.


Deep freeze.

Deep freeze.


Recurrent meningitis.

Recurrent meningitis.


Crime '65.

Crime '65.


Pregnancy and drug metabolism.

Pregnancy and drug metabolism.


A successful parasite.

A successful parasite.


Late-night education.

Late-night education.


Closure of umbilical blood vessels.

Closure of umbilical blood vessels.


Who goes to alcoholics anonymous?

Who goes to alcoholics anonymous?


Tetracyclines and the teeth.

Tetracyclines and the teeth.


A. A. O. audio-visual library listing--1966 additions.


Genito-urinary problems.

Genito-urinary problems.


Diagrammatic color slides quickly made. A new method from various materials.


Pacing on demand in the treatment of atrioventricular conduction-disturbances of the heart.


Genetic regulatory mechanisms and carcinogenesis.


Hypercalcemia of thyrotoxicosis.

Hypercalcemia of thyrotoxicosis.


Light-chain disease. An abortive variant of multiple myeloma.


Severe diarrhea controlled by gamma globulin in a patient with agammaglobulinemia, amyloidosis, and thymoma.


The effect of iodochloro-oxyquinoline and iopanoic acid on the determination of PBI and BEI.


A staining pool for mammalian eggs.

A staining pool for mammalian eggs.


The vascular pathology of thrombotic thrombocytopenic purpura. An immunohistochemical and ultrastructural study.


A syndrome of the neural crest.

A syndrome of the neural crest.


Fluorescence depolarization. II. The intramolecular relationships of the constituent fragments of gamma-globulin.


The negative staining of protein molecules.


Runt diseases as a model of immunosuppressive therapy.


On the distribution of rheumatoid factors among the immunoglobulins.


Some physical-chemical properties of chicken gamma-globulins and their pepsin and papain digestion products.


On the heterogeneity of the light chains of rabbit antibodies.


The Fd' fragment of human gamma-G immunoglobulin.


An analogue for negative staining.

An analogue for negative staining.


Properties of a virus-induced RNA polymerase in ascites cells infected with encephalomyocarditis virus.


Fluorescent staining techniques in early diagnosis of tissue alterations.


Allotypic specificities in pigs.

Allotypic specificities in pigs.


Relationships between Bucephalus sp. and Crassostrea virginica: a histochemical study of some carbohydrates and carbohydrate complexes occurring in the host and parasite.


The chemical nature and evolutionary significance of monogenean attachment sclerites.


The syndrome associated with midsystolic click and late systolic murmur.


Hyalinization of afferent and efferent glomerular arterioles in cyanotic congenital heart disease.


Testosterone potentiated 32P therapy in prostatic carcinoma.


Sedimentation analysis of a multiple myeloma gamma-G-globulin and one of its mercaptoethylamine reaction products.


Sedimentation analysis of a papain-digested human multiple myeloma gamma-G-globulin.


A comparison of currently popular thyroid function tests.


A rapid polychrome stain for epoxy-embedded tissue.


A simple rapid method for staining epoxy-embedded specimens for light microscopy with the polychromatic stain paragon-1301.


Ceruloplasmin rise and PBI fall in serum due to diphenylhydantoin.


Federal air pollution prevention and abatement responsibilities and operations.


The internal membranes of Caulobacter crescentus.


A histological and histochemical study of the glands of the external auditory canal of the dog.


Differentiation of epithelial and connective tissue components in the tongue of Gallus domesticus.


Observations on the mineral composition and staining properties of the inclusion bodies of infectious canine hepatitis.


Accumulations of fat in the brains of mice affected with scrapie.


Measurement of the colloid osmotic pressure in serum with Tybjaerg Hansen's osmometer.


Studies on the immunoglobulin spectrum of porcine serum and colostrum.


Observations on the use of progesterone impregnanted tampons in a herd of Dorset Hill sheep.


Morphological changes in glial cells during nerve regeneration.


Amino acid analyzer using 2,4,6-trinitrobenzenesulfonic acid.


Evaluation of the palliative effects of treatment with the 70-MEV synchrotron on advanced carcinoma of the bladder.


A procedure for the determination of total iodine in radioactive iodide preparations of high specific activity.


Twelve cases of pulmonary mycosis.

Twelve cases of pulmonary mycosis.


Hemodynamic features of extrasystoles in newborn and older infants.


Electrophoretic patterns in adult sheep on a magnesium-deficient diet.


Application of miniature goats in ruminant research.


The biochemical effects of coumaphos and three oximes on certain enzyme systems and blood protein elements in cattle.


Spontaneous atherosclerosis in the arterial system of aging swine.


Identification and virulence studies of Brucella strains isolated from Eskimos and reindeer in Alaska, Canada, and Russia.


Pathogenesis of skunk rabies virus: rabies inhibiting substance as related to rabies diagnosis.


Serum protein electrophoresis and serum transaminase activity of dogs with canine distemper.


Right colon by-pass for inoperable carcinoma of the oesophagus.


Radiology in epidemiological studies and some therapeutic trials.


Immunocytochemical localization of the immunoglobulin factors Gm(a), Gm(b) and Inv(a) in human lymphoid tissue.


Ultracentrifugal studies of the reactions of rheumatoid factor with native human gamma-G-globulin.


Recombination of heavy and light chains from human immunoglobulins.


The role of the sixth component of complement in some types of hypersensitivity.


Isolation and characterization of active fragments obtained by cleavage of immunoglobulin G with cyanogen bromide.


Effect of iodinated water supplies on thyroid function.


Studies of thyroid economy in two patients with phenylketonuria.


Tolerance to bovine gamma-globulin in adult guinea pigs.


Gamma-globulin and antibody formation in vitro. V. The secondary response made by splenic white and red pulp with reference to the role of secondary nodules.


Phagocytosis by guinea pig splenic cells of Escherichia coli and protein-coated bentonite particles labeled with iodine-125.


Erythroid aplasia following thymomectomy. Report of a case with a positive lupus erythematosus cell preparation and elevated plasma erythropoietin level.


Reaction of adenine-specific antibodies with denatured deoxyribonucleic acid.


Ultrastructural alterations in human liver disease.


Hereditary deficiency of the second component of complement (C'2) in man.


Reoperation in carcinoma of the colon following resection and adjuvant chemotherapy.


A survey of 302 transvesical prostatectomies with primary closure technique.


Preferential inhibition of RNA synthesis in Bacillus subtilis by actinomycin S.


Microscopical observations on the effects of phenanthroline chelates on Landschütz ascites tumour cells.


The importance of the growth-promoting alpha-globulin for cells in culture.


Technic for removal of whole retinas. SAM-TR-66-67.


Mucous thread in inferior conjunctival fornix. Qualitative analyses of the normal mucous thread.


Nasal decongestant properties of some tetrahydrothiophene-1,1-dioxide derivatives.


Immunologic studies in ataxia-telangiectasia. I. Delayed hypersensitivity and serum immune globulin levels in probands and first-degree relatives.


Do polymorphonuclear leukocytes play a role in passive cutaneous anaphylaxis of the guinea pig?


Serum protein alterations induced by Listeria monocytogenes infections.


The adjuvant action of endotoxin in thymectomized mice.


Plasmodial mitoses and polyploidy in the Myxomycete Physarum polycephalum.


The shortest peroxidase stain time and the mean cellular peroxidase content of blood leukocytes.


Unusual disease of pulmonary arteries with dyspnea. Structure-function relationships.


Asymptomatic monoclonal IgA hypergammaglobulinemia. A three year study.


Protein-bound iodine and abortion.

Protein-bound iodine and abortion.


Increased specificity of immunofluorescent reactions.


Immunologic and histochemical studies of lymph nodes after local administration of heterologous antigenic material. I. Cellular localization of antigenic material from chrysoidin hepatoma, livers of healthy mice and human gamma-globulin.


Field study of the effect of cold exposure and increased muscular activity upon metabolic rate and thyroid function in man.


Immunologic and histochemical studies of lymph nodes after local administration of heterologous antigenic material. II. Localization of antibodies, produced under the influence of antigenic material, obtained from chrysoidin hepatoma, livers of healthy mice and human gamma-globulin.


Comparison of the early thyroidal iodide clearance with estimates obtained at later intervals.


The properties of Shigella flexneri 1b strain carrying a lethal factor.


Antibiotic edeine. I. Isolation of induced high activity mutant of Bacillus brevis Vm4.


Antibiotic edeine. II. Morphological observations on Bacillus brevis Vm4 strain.


Falvin biosynthesis by Propionibacteria.


The influence of sodium deoxycholate and dimethylsulphoxide on the permeability of cell membrane of Schizosaccharomyces.


Dynamics of amylolytic enzymes synthesis in Aspergillus oryzae.


The effect of various humic fractions of peat on Bacillus subtilis and Escherichia coli.


Immunoglobulins in pediatric disorders an immunoelectrophoretic study.


Threonine dehydratase of streptomycin-dependent Escherichia coli K-12.


Effect of freezing on the corneal endothelium.


Validation of an indicator of mammalian retinal receptor response: density of stain as a function of stimulus magnitude.


Lysogeny in Rhizobium meliloti.

Lysogeny in Rhizobium meliloti.


Sequential UV-induced mutations in synchronized cultures of Escherichia coli K-12.


Investigations on the antigenic composition of Salmonella gallinarum and Salmonella pullorum.


Phospholipase C (phosphatidylcholine cholinephosphohydrolase) in Clostridium perfringens cultures.


Influence of root extracts and root exudates on respiratory activity of Azotobacter.


Optimal medium for synthesis of corrinoids by propionibacteria.


Bacterial associations of the Vistula (black and white Vistula streams).


The disinfection of infected store-rooms in archives, libraries and museums.


Contamination of chrome-tanned leather by Desulfovibrio.


Direct fluorescent labeling of microorganisms as a possible life-detection technique. Microorganisms and selected proteinaceous substances were directly tagged with fluorescein isothiocyanate. This approach suggested a possible application for detection of extraterrestrial life. A stable and apparently specific linkage was formed with protein, and nonprotein substances were readily destained. Soil and atmospheric debris did not exhibit any significant affinity for the dye.


Analysis of polycyclic aromatic hydrocarbons in petroleum waxes and white mineral oils with appraisal of merits of different methods of analysis.


Electron microscopy of guinea-pig epidermis stained by the osmium-iodide technique.


The role of diabetogenic hyperinsulinism in the pathogenesis of prostatic hyperplasia and malignancy.