Inhibition by streptovaricins of Rauscher leukemia virus splenomegaly. Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up to 6 h. SvC, at 300 mg/kg/day, reduced mean spleen weight of infected mice from 478 plus or minus 51 (SE) mg to 300 plus or minus 55 (SE) mg. Rifampicin, at 250 mg/kg/day, had no similar activity. Decrease in caloric intake and in body-weight gain also resulted in an inhibition of RLV splenomegaly; although Sv-treated mice gained weight, the increase was usually slightly less than controls. However, mice treated with a Sv diet for a week prior to infection, after an initial period of weight loss, gained at a rate equivalent to control group, and when killed had a marked reduction in splenomegaly. The selectivity of streptovaricins and specificity for viral events was suggested by several observations: (1) Splenomegaly and mortality, induced by L1210 or a non-infective transplantable tumor of RLV origin, was not inhibited. (2) No inhibition of normal hematopoietic spleen colonies was observed. (3) Host immune responses, including cellular and humoral immunity and interferon production and action, were not inhibited. Thus, although the effect of slightly decreased weight and intake could not be unequivocally established, the findings were most compatible with a selective inhibition of RLV splenomegaly by Sv.


Decrease of DMF-levels 4 years after the introduction of a caries-preventive program, observations in 5819 schoolchildren of 20 communities.


Psychotropic agents in the management of chronic asthmatic children.


Reduction of caries, gingivitis and calculus after eight years of preventive measures--observations in seven communities.


A study of the caries prevalence in first permanent molars of rural Zambian schoolchildren.


Sensitivity of the Faschingbauer abbreviated MMPI to hospitalized adolescents.


The effects of thyroid hormones on monoamine oxidase in the rat heart.


Phenylalanine, brain phenethylamine and motor activity in the rat.


New distribution and habitat records of biting midges and mangrove flies from the coasts of southern Baja California, Mexico (Diptera: Ceratopogonidae, Culicidae, Chironomidae, and Phoridae.


Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration.


Metabolic N- and alpha-C-oxidation of norephedrine by rabbit liver microsomal fractions and synthesis of the metabolic pdocuts.


Disulphide cross-linking of thiolated alpha-chymotrypsin to form macromolecules.


The dissolution of salicylic acid in micellar solutions of polysorbate 20.


The uptake of digoxin and digitoxin by some antacids.


Application of orthogonal functions to spectropolarimetric analysis of some penicillins.


A new colorimetric method for the determination of methyldopa.


The effect of dopamine and of apomorphine on dB-cAMP induced stimulation of synaptosomal tyrosine hydroxylase.


Lack of effect of protriptyline on the 6-hydroxydopamine-induced noradrenaline depletion in the rat spinal cord.


Acetylcholine activity in an identified 5-hydroxytryptamine containing neuron.


Neuroleptics: relation between cataleptic and anti-turning actions, and role of the cholinergic system.


The methylated derivatives of (+)-tubocurarine and its isomers.


Pharmacological activity of some bis-benzylisoquinoline alkaloids.


Different sensitivity to drugs eliciting homovanillic acid increase in two strains of mice.


Glucose absorption from the rat jejunum during acute exposure to metformin and phenformin.


Interactions of imipramine and synthesis inhibitors on biogenic amines.


Potency ratio between the beta-adrenoceptor stimulants isoprenaline and terbutaline on rabbit detrusor muscle.


Different types of drugs and their effects.


Potentiation of oxytocin and prostaglandins-evoked responses by (+) INPEA on isolated rat uterus: its specificity and selectivity. The effect of (+) IPNEA on various stimulant drugs was examined on isolated rat uterus. Addition of (+) IPNEA (1 times 10- minus 5 g/ml) to the organ bath, produced marked potentiation in the contractile responses of oxytocin and prostaglandins. Potentiation was less significant to 5-HT, vasopressin, angiotensin and bradykinin. (+) INPEA did not potentiate the responses of oxytocin on isolated rat mammary strip and the responses of prostaglandins on rat stomach (fundus) strip, guinea-pig tracheal chain and guinea-pig ileum. The significance of these findings has been discussed.


Depression and drug addiction.

Depression and drug addiction.


Neurohumors versus neurosecretion in the snail heart.


The relationship of achievement of psychiatrists to their personal adjustment as residents.


Successful treatment of severe experimental spinal cord injuries by intracisternal 3-alpha-dimethyltyrosine.


Lymphatic regenaration in the vascular island pedicle flap.


Activity of müllerian-inhibiting substance in postnatal testes.


Effects of premature puberty on cryptorchid testes in rats.


The susceptibility to acetylcholine and dopamine in the caudate nucleus of cats with chronic nigrostriatal lesions.


Elevation of brain gamma-aminobutyric acid in the mouse by L-2,4-diaminobutyric acid.


Optimal incubation conditions for the first step of amidopyrine-N-demethylation by 9000 times g liver supernatant of newborn and adult rats.


Antinuclear factors in relation to age, sex, mental disease and treatment with phenothiazines.


A controlled trial of clothiapine and chlorpromazine in acute schizophrenic syndromes.


Effects of histamine and noradrenaline on contractile force of guinea-pig ventricular strips: antagonism by burimamide and metiamide.


American Nurses' Association 1973 Legislative Conference. Mayflower Hotel; June 5-6, 1973, Washington, D.C. No. L-89.


Factors affecting the prevalence of dental fluorosis in Luknow, India.


The kinetic mechanism and properties of the cytoplasmic acetoacetyl-coenzyme A thiolase from rat liver. 1. Cytoplasmic acetoacetyl-CoA thiolase was highly purified in good yield from rat liver extracts. 2. Mg(2+) inhibits the rate of acetoacetyl-CoA thiolysis but not the rate of synthesis of acetoacetyl-CoA. Measurement of the velocity of thiolysis at varying Mg(2+) but fixed acetoacetyl-CoA concentrations gave evidence that the keto form of acetoacetyl-CoA is the true substrate. 3. Linear reciprocal plots of velocity of acetoacetyl-CoA synthesis against acetyl-CoA concentration in the presence or absence of desulpho-CoA (a competitive inhibitor) indicate that the kinetic mechanism is of the Ping Pong (Cleland, 1963) type involving an acetyl-enzyme covalent intermediate. In the presence of CoA the reciprocal plots are non-linear, becoming second order in acetyl-CoA (the Hill plot shows a slope of 1.7), but here this does not imply co-operative phenomena. 4. In the direction of acetoacetyl-CoA thiolysis CoA is a substrate inhibitor, competing with acetoacetyl-CoA, with a K(i) of 67mum. Linear reciprocal plots of initial velocity against concentration of mixtures of acetoacetyl-CoA plus CoA confirmed the Ping Pong mechanism for acetoacetyl-CoA thiolysis. This method of investigation also enabled the determination of all the kinetic constants without complication by substrate inhibition. When saturated with substrate the rate of acetoacetyl-CoA synthesis is 0.055 times the rate of acetoacetyl-CoA thiolysis. 5. Acetoacetyl-CoA thiolase was extremely susceptible to inhibition by an excess of iodoacetamide, but this inhibition was completely abolished after preincubation of the enzyme with a molar excess of acetoacetyl-CoA. This result was in keeping with the existence of an acetyl-enzyme. Acetyl-CoA, in whose presence the overall reaction could proceed, gave poor protection, presumably because of the continuous turnover of acetyl-enzyme in this case. 6. The kinetic mechanism of cytoplasmic thiolase is discussed in terms of its proposed role in steroid biosynthesis.


Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2. The amino acid sequence of the N-terminal 48 residues of the heavy chain derived from a homogeneous rabbit antibody to type III pneumococci is described. This chain of allotype a(2) is compared with other rabbit heavy chains of allotypes a(1), a(2) and a(3). Within the N-terminal 25 positions, two chains which carry the same allotype a(2) possess identical amino acid sequences, but differ markedly from heavy chains of allotypes a(1) and a(3). Sequence variability is observed in residues 26-27 and 30-34, but not in residues 35-48.


Monitoring in anesthesia. Monitoring depth of anesthesia.


Comparison of cardiorespiratory effects of rimiterol and terbutaline aerosols.


Adrenergic beta receptors in seminal vesicle.


Neuroendocrine mediating mechanisms: from the symbolic stimulus to the physiological response.


Anticholinesterase activity of some alpha-adrenergic blockers.


Moral and legal issues--nursing judgments.


Insulin, andeyl cyclate, ions, and the heart.


Sephadex gel filtration of gamma-glutamyl-transpeptidase, alkaline phosphatase and leucine aminopeptidase in the serum of patients affected by various liver diseases.


[Halogenated anesthetics effect on rat liver mitochondria].


A new enzymatic method for the estimation of inorganic phosphate in native sera.


Pharmacological approaches to the therapy of angina.


Approach to a combined pharmacologic therapy of childhood hyperkinesis.


Ecological genetics of the wild rabbit in Australia. I. Geographical distribution and biochemical characterization of phosphogluconate dehydrogenase variants.


Clinical experience with pipothiazine palmitate (19552 R.P.) in hospitalized and open ward patients with functional psychoses.


Compendium of pharmacology.

Compendium of pharmacology.


Association of xanthine oxidase with the bovine milk-fat-globule membrane. 1. The catalytic properties of xanthine oxidase in bovine milk (EC 1.2.3.2) are dependent on the state of the enzyme, i.e. whether free or bound to the fat-globule membrane. Oxidase activity of the membrane-bound enzyme towards NADH is enhanced relative to that towards xanthine. This reflects a change in the relative K(m) values and enables the ratio of xanthine to NADH oxidase activities (X/N) to be used as a parameter for the relative amounts of free and membrane-bound xanthine oxidase in milk fractions. 2. Chromatography of buttermilk on Sepharose 2B yielded an excluded fraction, BM(1), with xanthine oxidase activity. The remaining xanthine oxidase activity was eluted as a single broad peak. This was further resolved on Sephadex G-200 into an excluded fraction, BM(2), and free xanthine oxidase. Fractions BM(1) and BM(2) had X/N values in the range 45-65, which is characteristic of membrane-bound xanthine oxidase. Purified xanthine oxidase has a mean X/N value of 110.3. Addition of fraction BM(1), heated to remove associated enzyme activities, to purified xanthine oxidase progressively enhanced its NADH oxidase activity to a value where its X/N value was characteristic of membrane-bound xanthine oxidase. This was shown to be due to binding of free enzyme to heated fraction BM(1). The binding constant and stoicheiometry were determined. 4. Proteolytic digestion of fraction BM(1) liberated free xanthine oxidase from the fat-globule membrane with a corresponding alteration in X/N value.


The efficacy of systematic desensitization via imagery as a therapeutic technique with stutterers.


Abuse of psychopharmacological drugs  experiences in Norway.


Bronchodilators.  Part I.

Bronchodilators.  Part I.


Circadian chronotypic induction of tyrosine aminotransferase and depletion of glycogen by theophylline in the rat.


Goldthioglucose-induced lesions and quantitative changes of monoamines in the rat brain.


Enzyme histochemical studies of adipose tissue in porcine yellow fat disease.


Hormone implants in the climacterium.

Hormone implants in the climacterium.


Paper-chromatographic analysis of NADH2-oxidase and NH3-dependent NAD-reductase activity in choloragosome lipopigment of lumbricidae.


Guamecycline in bronchial infections due to Diplococcus pneumoniae.


AMN-analgesia : preliminary results.

AMN-analgesia : preliminary results.


Clinical experimentation with flunitrazepam (Ro 05-4200).


Hemodynamic studies of flunitrazepam or RO 05-4200 injection in man.


A comparative clinical study of flunitrazepam with thiopentone as an anesthetic agent.


Laboratory investigations of neuroparalytic accidents associated with suckling mouse brain rabies vaccine.  I.--Encephalitogenicity and virological studies.


Clinical control charts.

Clinical control charts.


Pulmonary hypertension in Takayasu's arteritis.


Isolation of mutations in Dictyostelium discoideum affecting alpha-mannosidase.


Characterization of differentiated and dedifferentiated clones from a rat hepatoma.


Selective T cell killing of human lymphocytes by ultraviolet radiation.


Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.


The influence of a graft-versus-host reaction on the incidence of metastases after tumor transplantation.


The effect of allogeneic spleen cells on the induction of immunologic tolerance.


Misunderstanding or error? The UGDP report after four years.


Studies of the immunological capacity of germ-free mouse radiation chimeras. IV. Cell-mediated immunity.


Alterations in hexose monophosphate shunt during lymphoblastic transformation.


First appliance of dental injuried patients to the dentist.


Occupational health criteria for the evaluation of pesticides. Conclusions and recommendations of a workshop, Sofia, Bulgaria, April 9-11, 1974.


Dental caries in school children at Shfar'am. An epidemiological study of an Arab population.


Editorial: Six years of the International Union of Immunological Societies. Presidential report (Brighton, 1974).


Proceedings: Interaction between GABA and butyrophenones in cerebellar purkinje cells in cats.


Proceedings: GABA concentration in the layers of the superior colliculus.


Proceedings: Effect of an autonomic ganglion blocking agent on plasma sodium concentrations in renal arteries and veins during sustained renal vein congestion.


Inhibitory beta adrenergic receptors in the nictitating membrane of cat.


Adrenoceptors in the heart of rana tigrina.


Anaesthesia and intensive care in eclampsia.


Fundus lesions in connective tissue disease.


A rapid selective medium for the determination of trimethylamineoxide-reducing bacteria.


Observation on receptor specific proteins I. Haemagglutination and haemagglutination-inhibition reactions of two mannose-resistant strains of Escherichia coli.


Humoral antibody response and GVH reactivity with neuraminidase treated murine lymphocytes as donor cells.


Reduction of GvH splenomegaly in mice by antilymphocyte serum (ALS): correlation of the effect with immunosuppressive potency of ALS.


Six years of the International Union of Immunological Societies. Presidential report, Brighton 1974.


The Emperor's New Clothes: the reality of darvon-N.


"I got a yen for that darvon-N": a pilot study on the use of propoxyphene napsylate in the treatment of heroin addiction.


Treatment of polydrug users in San Francisco.


Changing patterns of drug abuse in New York City.


Determination of microquantity of ethylphenylephrine in plasma by radioisotope derivative method using p-toluenesulfonyl[35S] chloride.


Synthesis of tryptic peptides of hen egg lysozyme (positions 1-5 and 69-73) and related peptides.


The quest for coupling site 1.

The quest for coupling site 1.


Quantitative correlation between pyrrolidonyl peptidase activity and coagulase of Staphylococci.


First results and experiences with our prematurity and dysmaturity prevention program (PDP-program).


Effects of sympathomimetic tocolytic agents on the fetus.


Ferredoxins and photosynthesis.

Ferredoxins and photosynthesis.


Tocolytic therapy in obstetrics.

Tocolytic therapy in obstetrics.


Pharmacological blockade.

Pharmacological blockade.


Sixth annual symposium on the medical aspects of sports.


Cardiovascular events in anxiety in trained dogs: pharmacological aspects.


Sympathetic control of coronary and systemic hemodynamics in emotional stress in the conscious dog.


Effect of beta-receptor blockade upon myocardial hemodynamics and nutritional circulation in the heart.


Mechanochemical coupling at the actomyosin cross-bridges and the adrenergic inotropic receptor.


Certain concepts in the epidemiology of filariasis. A critical review.


[Emergency measures the diagnosis and therapy of disseminated intravascular coagulation].


Further data to anaphylaxis in the cat.

Further data to anaphylaxis in the cat.


Pharmacological studies of some central effects of tempidon.


Synthesis of dihydrodipicolinate synthetase in Escherichia coli K12.


Actions of vertebrate sex hormones.

Actions of vertebrate sex hormones. A review of actions of vertebrate sex hormones is presented.  The main topics of discussion are: 1) intracellular proteins binding sex hor mones and their metabolites (estrogen uptake by intact normal cells;  upt ake of estrogens by mammary gland, and by mammary and other tumors;  ster eospecific estrogen-binding proteids in responsive tissues;  uptake of androgens by animal cells and formation of 5alpha-androstane and other derivatives;  5alpha-dihydrotestosterone-binding proteids;  disposition of progesterone in various tissues);  2) testicular feminization syndrome;  3) effects of sex hormones on organ cultures, with comments on deoxyribonucleic acid synthesis and cell division in relation to tissue growth;  4) estrogen-mediated pyridine nucleotide transhydrogenase reactions;  5) intracellular "2nd messengers" and sex hormone action (polyamines);  6) physiological actions of 5beta-hydrogenated steroid metabolites and effects of sex hormones on erythropoiesis;  7) influences of sex hormones on structure, metabolism, and functions of reproductive organs (ribonucleic acid - RNA - and protein synthesis;  RNA preparations and genital tissue growth;  androgens and cation-activated adenosinetriphosphatase reactions;  uptake of glucose and glycogen synthesis;  mitochondrial reactions;  gonadal hormones and sebaceous glands); and 8) medieval Chinese protoendocrinology.


Cyclic nucleotides.

Cyclic nucleotides.


The biosynthesis of granulose by Clostridium pasteurianum. 1. Mutant strains of Clostridium pasteurianum were obtained, which are unable to synthesize granulose (an intracellularly accumulated amylopectin-like alpha-polyglucan). 2. These mutants lacked either (a) ADP-glucose pyrophosphorylase (EC 2.7.7.27), or (b) granulose synthase (i.e. ADP-glucose-alpha-1,4-glucan glucosyltransferase, EC 2.4.1.21). 3. Although both of these enzymes were constitutively synthesized by the wild-type organism, massive deposition of granulose in a sporulating culture coincided with a threefold increase in the specific activity of ADP-glucose pyrophosphorylase. 4. The soluble ADP-glucose pyrophosphorylase was partially purified (33-fold). Its ATP-saturation curve was not sigmoidal and its activity was not enhanced by phosphorylated intermediates of glycolysis, pyruvate, NAD(P)H or pyridoxal 5'-phosphate. ADP at relatively high concentrations acted as a competitive inhibitor (K(i)=19mm). 5. The dependence of granulose synthase on a suitable polyglucan primer was demonstrated by using enzyme obtained from a granulose-free mutant strain (lacking ADP-glucose pyrophosphorylase). 6. Partial purification of granulose synthase from wild-type strains was facilitated by its being bound to the native particles of granulose. No activator was discovered, but ADP, AMP and pyridoxal 5'-phosphate were competitive inhibitors, ADP being most effective (K(i) about 0.2mm). 7. It would appear that the synthesis of granulose in Cl. pasteurianum is not subject to the positive, fine control that is a feature of glycogen biosynthesis in most bacteria.


Mobilization of granulose in Clostridium pasteurianum. Purification and properties of granulose phosphorylase. 1. The granulose of Clostridium pasteurianum ATCC 6013 is degraded when the organism is incubated in a medium containing no utilizable source of carbon and energy. 2. Mobilization of the polyglucan does not occur in the presence of exogenous glucose. 3. Breakdown of granulose is effected by a constitutively synthesized alpha-1,4-polyglucan phosphorylase. 4. Partial (530-fold) purification of this granulose phosphorylase was facilitated by its being loosely bound to the native granules of its substrate polyglucan. 5. The enzyme (pH optimum 6.4) was assayed both (a) in the degradative direction, K(m) for P(i)=2.2mm, and (b) in the synthetic direction, K(m) for glucose 1-phosphate=0.05mm. No requirement for bivalent cations was evidenced. 6. Granulose phosphorylase was inhibited by various nucleotide sugars; GDP-glucose, ADP-glucose (K(i)=20mum) and UDP-glucose (K(i)=60mum) were particularly potent competitive inhibitors. ATP, NADP(+) and NADPH (at 1mm) were less effective inhibitors, whereas AMP was slightly stimulatory. 7. It would appear that granulose mobilization is favoured under conditions of low adenylate energy charge, but is prevented under conditions of ;glucose excess' chiefly by ADP-glucose-mediated inhibition of granulose phosphorylase.


Modulation of the immune response to transplantation antigens. III. Further studies on the effects of Freund's complete adjuvant on the immune response of mice to allogeneic tumour antigen.


Enhancement and depression of the antibody response in mice caused by Corynebacterium parvum.


Spontaneous and induced generation of optical activity in racemic 1,1'-binaphthyl.


Sexual dysfunction resulting from drug side effects.


An evaluation of sotalol, a beta-blocking agent, in patients with angina pectoris.


[Severe endemic trachoma in Tunisia: changes in ocular bacterial pathogens in children treated by the intermittent antibiotic regimen].


Influence of the drugs on the immuno-allergic reactivity. IV. The action of tranquillizers on passive anaphylaxis in guinea-pig.


Microbial Decomposition of alpha-Picoline. An organism, which degrades alpha-picoline but also utilizes 2-ethylpyridine or piperidine as alternative growth substrates, has been isolated from soil and characterized as arthrobacter sp. alpha-picoline-grown cells oxidize 2-ethylpyridine and vice versa. Other pyridine derivatives tested are neither utilized as growth substrates nor oxidized by the organism. alpha-Picolinate and 2-hydroxy-6-methylpyridine are not metabolized, indicating that degradation is neither initiated by methyl oxidation nor by hydroxylation in the 6-position of pyridine ring. Succinate semi-aldehyde and pyruvate accumulate when alpha-picoline oxidation by resting cell suspensions is blocked by semicarbazide. The Arthrobacter grown on alpha-picoline rapidly oxidizes succinate semi aldehyde...


The effect of antilymphocytic antibody on the humoral immune response of different strains of mice. V. Effects on the class and subclass of antibody produced, and the antibody responses of congenitally athymic mice.


Effects of alpha receptor blocking agents on tissue oxygenation during extracorporeal circulation.


Pharmacologic and therapeutic aspects of fluoride.


Pathology of hypertrophic obstructive cardiomyopathy.


Diagnostic consistency in catatonic schizophrenia.


An ultrastructural study of axonal changes following constriction of postganglionic branches of the superior cervical ganglion in the rat.


Histaminergic pathway in rat brain evidenced by lesions of the medial forebrain bundle.


Synergism of insecticides by herbicides: effect of environmental factors. The synergism of parathion and p,p'-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane] by atrazine was investigated as a function of soil type, age of pesticide soil residues, and the presence of soils in quiet or turbulent water. Compared to previous tests in which the pesticides were applied on glass surfaces, a significant reduction of the toxicity of the insecticides to fruit flies and of the synergistic effects of atrazine was observed with soils, particularly a silt loam. The effects of atrazine as a synergist in soil declined rapidly within 4 days. The toxicity of parathion in water and its synergism by atrazine were significantly reduced by soil sediments, depending on the type and amount of soil present. Soils were highly effective in turbulent water: in water containing the relatively high parathion concentration of 0.3 part per million, 93 percent of the mosquito larvae present died within 24 hours, yet this solution was rendered nontoxic by being mixed with 5 grams of a loam soil. With atrazine present in the latter system, however, 38 percent of the mosquito larvae died. Thus, insecticides can be more or less toxic, depending on their concentrations, the presence of synergists, and the environmenetal conditions.


The mechanism of the effect of increased biliary pressure on hepatic circulation.


Influence of adrenergic blocking agents on lysine-vasopressin induced plasma cortisol response in man.


Nicotinic acid as adjuvant therapy in newly admitted schizophrenic patients. A placebo-controlled, comparative clinical study was conducted to test the hypothesis that nicotinic acid as an adjuvant medication has a beneficial therapeutic effect over and above the effect which can be achieved by the administration of phenothiazine drugs alone, over a six-month period, in newly (recently) admitted schizophrenic patients.The most important single finding was that no statistically significant therapeutic difference was seen between the active treatment and the placebo groups; i.e., the addition of nicotinic acid or nicotinamide to the regular phenothiazine treatment regimen did not have any measurable therapeutic effect in this sample of patients. It was shown that patients in the placebo group received a lower total daily amount of phenothiazine drugs than those on either of the active substances. Furthermore, it was noted that the addition of the active substances did not reduce the number of days of hospitalization.


Sea anemone collagen: further evidence for the existence of only one alpha-chain type.


Facultative IgG paraproteinaemia in polyarteritis nodosa.


Report on AMSUS--80th annual meeting.

Report on AMSUS--80th annual meeting.


Navy allied health science program.

Navy allied health science program.


Ultrastructural changes in skeletal muscle of rats treated with emetine and dehydroemetine.


The uptake of [3H]gamma-amino butyric acid and [3H]glycine by the isolated retina of the frog.


Calcium antagonism and its effect on the inhibitory actions of biogenic amines on cerebral cortical neurones.


The release of amino acids with proposed neurotransmitter function from the cuneate and gracile nuclei of the rat in vivo.


Effect of hyperphenylalaninemia on amino acid metabolism and compartmentation in neonatal rat brain.


Effect of pentobarbital on uptake and release of [3H]GABA and [14C]glutamate by brain slices.


Cardiovascular and cardiac fine structural effects of the nonequilibrium alpha-blocking agent, EEDQ.


Proceedings: A study of the involvement of adrenergic receptor stimulation in the mobilization of leucocytes in human subjects.


Proceedings: The effect of dehydroemetine on vascular tissue.


Dextrans.

Dextrans.


Enzymes of carbohydrate metabolism in human epidermal tumors. 1. Lactate, malate, and isocitrate dehydrogenases, alanine and aspartate aminotransferases.


Arterial oxygen tension during apnoea in parturient women.


Letter: Medical auxiliaries.

Letter: Medical auxiliaries.


The main clinical classifications of neuroleptics.


Scandinavian standpoint on the Liege classification of neuroleptics.


Development of communicating nursing research series.


Changing approaches to nursing research in the West.


Autonomic neuromuscular transmission.

Autonomic neuromuscular transmission.


The effect of chlorhexidine on oral anaerobes in relation to mixed infection.


Vitamins and their carrier proteins in fatty acid synthesis.


A diploid rat liver cell culture. 1. Characterization and sensitivity to aflatoxin B1.


Adult liver parenchymal cells in primary culture characteristics and cell recognition standards.


Regulation of glutamine synthetase in L cells by cortisol and L-glutamine.


C.D.A. conference on dental auxiliaries: viewpoints. "You are on a course of action".


Connective tissue diseases.

Connective tissue diseases.


Respiratory diseases.

Respiratory diseases.


Report to the Canadian Dental Association Council on Health Care.


The pattern of dental caries in Egyptian school children.


Prevalence of dental caries and periodontal disease.


Primary monolayer cultures of adult rat liver parenchymal cells suitable for study of the regulation of enzyme synthesis.


Dento-maxillary injuries of children.

Dento-maxillary injuries of children.


Peculiarities in dermatology. Carbromal causing nonthrombocytopenic purpura.


Defective molecular variants of glucose-6-phosphate dehydrogenase and methaemoglobin reductase.


Sphingolipidoses.

Sphingolipidoses.


Treatment of behaviour disorders in children with clinical and bioelectrical episodic symptomatology. Fifty five children with episodic behaviour disorders and other behaviour disorders and a paroxysmal EEG pattern were examined clinically, psychologically and electroencephalographically. A detailed environmental analysis of social factors was made in each case. The aim of the study was a comparative analysis of the symptomatology and effects of treatment in behaviour disorders of children with and without an early lesion of the central nervous system. The authors have discussed the EEG-clinical correlations, the relationship between the effects of treatment and the clinical syndrome and EEG changes during treatment in the observed groups of children. The role of psychotherapy is emphasized, especially the influence of different environmental factors at home and at school.


Endocardial lesion in a case of Takayasu's arteriopathy. The clinical findings and the necropsy report of a 14-year-old girl suffering from Takayasu's arteriopathy have been presented. In addition to the typical arterial changes, thickening and puckering of the aortic valve and a patch of thickening in the left atrial endocardium were shown at necropsy. The histology of this lesion was found to be identical with the arterial intimal changes. It has been postulated that Takayasu's arteriopathy may rarely extend to the valvular and mural endocardium of the heart, producing cardiac murmurs. Similar cases with cardiac murmurs reported earlier and attributed to associated rheumatic endocarditis were probably due to the same pathological process extending to the endocarditis.


Influence of hemoglobin concentration in perfusate and in blood on fluorescence of pyridine nucleotides (NADH and NADPH) of rat liver.


The present status of focal glomerulonephritis.


Electrical burns. A clinical and experimental study with special reference to peripheral nerve injury.


The validity of mitochondrial marker enzymes in rat heart.


The effects of "personality" and isolated demographic variables on adverse postpartum reactions: an attempt at prediction.


Beta-adrenergic blocking agents and anaesthesia: a review.


Water economy of the canyon mouse Peromyscus crinitus stephensi.


Therapeutics in dentistry. Analgesics: 1.


The application of invertebrate tissue culture in arboviruses studies.


Studies on arboviruses. Considerations on mosquito vectors of arboviruses in Rio de Janeiro.


Inhibitory beta-adrenoceptors in the urinary bladder of the rat.


Effects of intraventricular brain injections of neurotransmitters on colonic temperature in morphine-tolerant rats.


Effects of neurotransmitters and other pharmacological agents on 32Pi incorporation into phospholipids of the iris muscle of the rabbit.


Daily rhythms in tyrosine transaminase and other hepatic enzymes that metabolize amino acids: mechanisms and possible consequences.


Central and peripheral alpha adrenergic activity of imidazoline derivatives.


Biochemical studies on sub-fractions of rat liver mitochondria.


Functional significance of alpha-stimulation and alpha-blockade on responses to cardiac nerve stimulation in anesthetized dogs.


Neurochemical correlates of synaptically active amino acids.


The use of the immobility reflex (animal hypnosis) as a possible procedure for detecting sedative activity.


Regulation of tryptophan and tyrosine hydroxylase.


The hepatic microsomal metabolism of beta-3,4-methylenedioxyamphetamine (MDA).


Monoamine oxidase inhibition: possible mechanism for cyproheptadine-induced alterations in insulin secretion.


Pyridine nucleotides in the thyroid gland. II. Effect of nicotinamide, nicotinic acid and L-tryptophan administration.


Effect of sodium dodecyl sulfate on the kinetic properties and molecular weight of rat striatal tyrosine hydroxylase.


Thyroxine stimulation of rat liver microsomal NADH-cytochrome c reductase in vitro.


Role of peripheral resistance in the control of cardiac output.


Primary arteritis of the aorta and its main branches (Takayasu's arteriopathy). A clinicopathologic autopsy study of eight cases.


Long-term follow-up study of periarteritis nodosa.


A possible mechanism for the anti-depressant activity of thyrotropin releasing hormone.


The use of autoradiographic techniques for the identification and mapping of transmitter-specific neurones in the brain.


Effects of hypophysectomy on unilaterally cryptorchid rats.


The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias.


Effect of angiotensin and beta-adrenergic stimulation on venous smooth muscle.


Some pharmacological actions of the beta-adrenolytic agent Ro 3-3528 (6,7-dimethyl-alpha-[(isopropylamino) methyl]-2-benzofuranmethanol Hydrochloride).


Early surgical intervention for aortic insufficiency due to bacterial endocarditis.


Recommendations of the Laser Safety Conference.


Effect of steroids and cofactors on the activity and stability of human placental glutamate dehydrogenase.


Psychosocial conferences in medical oncology. Role in a training program.


Cholinergic enzyme systems in Parkinson's disease.


Psychosomatic aspects of Ménière's disease.


Paradoxical effect of ALS.

Paradoxical effect of ALS.


Early operation for the undescended testis.


Alteration of myocardial performance during thermal stress by beta adrenergic blockade.


Treatment of emotional problems in adolescents.


Changes of venous return and other hemodynamic parameters during bradykinin infusion.


Detection of arboviruses by sentinel hamsters during the low period of transmission.


Evaluation of neurohumoral substances in local regulation of blood flow.


Paradoxical effect of anti-thymocyte serum on the thymus.


Indian Academy of Pediatrics. The Second National Conference.


Hypotensive effect of phenothiazines.

Hypotensive effect of phenothiazines.


Inaugural address.

Inaugural address.


The merits of an evening arthritis clinic.


Bilateral symmetrical march fractures simulating juvenile rheumatoid arthritis.


Pheochromocytoma and medullary carcinoma of thyroid.


Diffuse phlegmonous gastritis. A rare complication of pneumococcal endocarditis.


Drug metabolizing ability in operating theatre personnel.


The mode of action of promethazine in potentiating narcotic drugs.


Metabolic assessment of internal mammary artery implantation in the dog.


Direct blood flow studies of clinical internal thoracic (mammary) arterial implants.


Internal mammary artery implantation: effect on myocardial lactate utilization.


Reactivity of the vessels of collapsed and ventilated lungs to drugs and hypoxia.


Myocardial oxygen consumption in acute experimental cardiac depression.


Radioautographic studies in vitro of DNA and RNA synthesis in experimentally produced cryptorchidism in the Fischer rat.


Comparison of ethamivan and doxapram in the management of postanesthetic respiratory depression.


Some relationships between drugs and ions at a ganglionic synapse.


Action of caffeine and theophyllamine on supersensitive dopamine receptors: considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists.


XXV Nordic Congress of Pneumonology. Goteborg, 1970. Abstracts.


Endocrine tumours of neural crest origin: neurolophomas, apudomas and the APUD concept.


Stereochemical mapping of the active site of glutamine synthetase.


Evaluation of aquarium antibiotic formulations. The antibacterial activity of eight products marketed for the therapy and prophylaxis of diseases of ornamental fishes was tested. The products contained erythromycin, neomycin, a nitrofuran, penicillin, sulfa compounds, streptomycin, or tetracycline. When used at the concentration recommended by the manufacturer, the products failed to inhibit the growth of bacterial species known to be potential pathogens of ornamental fishes and failed to reduce significantly the bacterial numbers in water containing fish. Concentrations of the products that were bacteriostatic were markedly higher than the in-use concentration recommended by the manufacturer. The danger presented by the unrestricted availability of antibiotic compounds frequently used in the treatment of human and animal disease is discussed.


Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine. The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH(3)UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH(3)UdR, simultaneous addition of OCH(3)UdR with virus to the cells, and postinfection treatment with OCH(3)UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH(3)UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The alpha-anomer of OCH(3)UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH(3)UdR has a very low acute toxicity.


Biochemical and genetic basis of tetracycline resistance in Staphylococcus aureus. Both the genetic and biochemical basis of tetracycline resistance in a number of staphylococcal strains was investigated. The strains examined could be classified into three groups: (i) those possessing a high basal level of resistance and in which resistance could be induced to higher levels (macro-inducible); (ii) those which had a high uninduced level of resistance, but which were virtually uninducible (macro-constitutive); (iii) one derivative which had a low basal level of resistance and was also uninducible (micro-constitutive). Resistance in macro-constitutive strains was plasmid mediated and typical of organisms possessing wild-type plasmids. The macro-constitutive pattern of resistance appeared to be correlated with a chromosomal location for the resistance genes, whereas the micro-constitutive pattern was correlated with loss of a region from the wild-type plasmid. Analysis of membrane proteins by sodium dodecyl sulfate polyacrylamide gel electrophoresis suggested that a number of membrane polypeptides became unstable in staphylococci possessing high-level tetracycline resistance. In particular, the absence of a polypeptide of 22,000 daltons was always associated with high-level resistance. There was no evidence that multiple gene copies are required for expression of tetracycline resistance in Staphylococcus aureus.


Polyene-resistant mutants of Aspergillus fennelliae: identification of sterols. Four mutants strains of Aspergillus fennelliae resistant to various polyene antibiotics have been analyzed for their sterol content. The mutant strains contained Delta(7,22,24(28))-ergostatrien-3beta-o1 and Delta(7,22)-ergostadien-3beta-o1 as the major sterols, whereas the wild types contained ergosterol, indicating that the mutants contain metabolic blocks for C(5)-C(6) dehydrogenation and C(24)-C(28) reduction in the biosynthesis of ergosterol. Revertant sectors arising from the mutant colonies contained either more Delta(7,22)-ergostadien-3beta-o1 than the parent mutant strain or showed the reappearance of ergosterol. The revertant sectors also showed lower resistance to amphotericin B and a higher rate of sporulation than the parent mutant strain. These results confirm our previous observations that the presence of ergosterol is directly related to the drug susceptibility and the normal rate of sporulation in this species.


Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci. Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.


Binding of aminoglycosides to feces.

Binding of aminoglycosides to feces. Gentamicin and several other basic antibiotics were examined for their ability to adsorb to dog feces. It was found that 44 to 90% of all antibiotics studied were adsorbed to feces depending on the ratio of antibiotic to fecal material. Attempts to extract these antibiotics by acid treatment after adsorption onto feces were only partially successful since large portions of the bound materials were not removed.


Ampicillin resistance of Shigella sonnei. The ampicillin resistance of clinical isolates of Shigella sonnei is due to beta-lactamase production. Two kinds of resistance are found: low level, nontransmissible; and high level, tranmissible. The nontransmissible type of resistance results from a chromosomal mutation which increases the production of a beta-lactamase that hydrolyses cephalosporins relatively rapidly and gives cephalothin resistance. The transmissible type of resistance is due to an R factor mediating the synthesis of a different beta-lactamase that does not significantly hydrolyze cephalosporins or confer cephalothin resistance. One clinical isolate is shown to possess simultaneously both these mechanisms of ampicillin resistance.


Inactivation of endotoxin by polymyxin B. The limulus gelation assay was utilized to investigate endotoxin inactivation by a number of antibiotics in vitro. Endotoxin activity was sharply reduced by polymyxin B and sodium colistimethate. The effect of the polymyxin was not significantly inhibited by 0.001 M calcium or 90% serum. Crude endotoxins from a variety of aerobic gram-negative bacteria, including several not previously studied, could be inactivated 1 or more logs by as little as 1 mug of polymyxin B per ml, whereas Bacteroides fragilis endotoxin was poorly detoxified. A 10,000-fold range in the relative susceptibility of different endotoxins to inactivation by polymyxin B was found. The endotoxin most susceptible to polymyxin B was derived from an organism resistant to polymyxin B by disk sensitivity testing, suggesting that the bacteriocidal and endotoxin detoxifying properties of polymyxin need not be directly related.


Biliary tract excretion of cefazolin, cephalothin, and cephaloridine in the presence of biliary tract disease. The biliary tract excretion of three cephalosporins, cefazolin, cephaloridine, and cephalothin, was compared in patients with biliary tract disease. In the absence of obstruction, mean antibiotic levels in bile from gall bladder and common duct in patients undergoing cholecystectomy were highest for cefazolin (17 and 31 mug/ml, respectively) than either cephaloridine (7 and 9 mug/ml) or cephalothin (1 and 4 mug/ml). Biliary tract levels generally paralleled serum levels. In no patient with cystic duct obstruction were any of the cephalosporins detectable in appreciable amounts in gall bladder bile. In patients with T-tube drainage given each of the three different cephalosporins on separate days, concentrations of cefazolin in bile were many-fold higher than either cephaloridine or cephalothin. Peak levels of cefazolin in T-tube bile averaged 51 mug/ml after intravenous and 26 mug/ml after intramuscular administration, whereas mean peak levels of cephalothin and cephaloridine were only 6 and 16 mug/ml, respectively. Here, too, T-tube levels reflected serum concentrations and obstruction to biliary flow impaired excretion of each of the drugs.


Cinoxacin: effectiveness against experimental pyelonephritis in rats. The antimicrobial activity of cinoxacin, 1-ethyl-4(1H)-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid, previously reported as compound 64716, was determined and compared with other antimicrobial agents at a dosage of 12 mg/kg once daily in a descending pyelonephritis rat model with Escherichia coli and Proteus mirabilis as infecting organisms. Cinoxacin was considerably more effective than either nalidixic acid or oxolinic acid when all three were administered orally at 3 mg/kg four times daily. The presence of demonstrable serum activity with a high recovery in urine indicates cinoxacin possesses highly desirable properties of an effective oral chemotherapeutic agent for urinary tract infections.


Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives. Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose probenecid, CSF penicillin levels increased two to three times as did CSF concentration as a percentage of serum level. The same probenecid effect was consistently demonstrated in animals with experimental pneumococcal meningitis. Probenecid likewise increased the CSF concentration of ampicillin, carbenicillin, nafcillin, cephacatrile, and cefazolin. Probenecid may prove useful in certain bacterial infections where high CSF antibiotic levels are necessary.


Comparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa. The effect of gentamicin against 130 clinical isolates of Pseudomonas aeruginosa was compared with that of two investigational aminoglycoside antibiotics, tobramycin and amikacin. Minimal inhibitory concentration data indicated that, on a weight basis, tobramycin was two to four times as active as gentamicin against most isolates. However, 14 of 18 organisms highly resistant to gentamicin (>/=80 mug/ml) were also highly resistant to tobramycin. Amikacin was the least active aminoglycoside on a weight basis, but none of the isolates were highly resistant to this antibiotic. When therapeutically achievable concentrations were used, adding carbenicillin to gentamicin or to tobramycin enhanced inhibitory activity against those isolates susceptible (</=5 mug/ml) or moderately resistant (10 to 40 mug/ml) to the aminoglycoside. Such synergy was seldom demonstrated for isolates highly resistant to gentamicin or tobramycin. The combination of carbenicillin and amikacin enhanced inhibition against all but two of the isolates. Both tobramycin and amikacin offer in vitro advantages over gentamicin against P. aeruginosa.


Production of cephalosporin C by Paecilomyces persicinus P-10. After the growth of Paecilomyces persicinus P-10 in a glucose-peptone medium, filtrates were collected and analyzed for antibiotic antivity. Activities against Salmonella gallinarum ATCC 3030 and Alcaligenes faecalis ATCC 8750 (penicillin N-resistant strain) were obtained. Part of the former activity was readily inactivated by penicillinase. The fraction active against A. faecalis was isolated by passage through Amberlite XAD-2 and Amberlite IRA-68. The powder eventually obtained was subjected to paper chromatography followed by bioautography, and the activity obtained corresponded to that of a sample of cephalosporin C. Thin-layer chromatography was also employed to verify the presence of cephalosporin C in the P-10 powder. The active solids were further purified by means of paper chromatography in a solvent system consisting of n-butanol-acetic acid-water (60:15:25, vol/vol). The material obtained from this procedure yielded an infrared absorption spectrum identical to that of cephalosporin C. Similarly, the ultraviolet absorption of the purified preparation coincided with that of cephalosporin C. Exposure of the purified solids to cephalosporinase resulted in rapid inactivation of the antibiotic. In addition to penicillin N and cephalosporin C, filtrates of P. persicinus P-10 also contained deacetylcephalosporin C, deacetoxycephalosporin C, and cephalosporin P.


Evaluation of two standardized disk methods for testing antimicrobial susceptibility of Pseudomonas aeruginosa and of the Enterobacteriaceae. Two standardized disk diffusion susceptibility testing methods were compared using Pseudomonas aeruginosa and members of the Enterobacteriaceae. The standard Bauer-Kirby method and the agar overlay method of Barry et al. were compared using carbenicillin (50- and 100-mug disks), gentamicin, polymyxin B, and colistin sulfate. Both methods gave nearly comparable zone sizes with the enteric bacilli. However, with P. aeruginosa the agar overlay method gave zones 1 to 2 mm smaller than the Bauer-Kirby method with all drugs except gentamicin. In spite of these small differences, further examination of minimal inhibitory concentration-zone size correlations indicated that the same interpretive zone standards can be applied to either diffusion technique. For testing carbenicillin against Pseudomonas sp., 50-mug disks were unsatisfactory, especially with the agar overlay method; 100-mug disks were far superior with both methods.


Comparison of the in vitro activity of BL-P1654 with gentamicin and carbenicillin against Pseudomonas aeruginosa. The in vitro activity of 6-[d-alpha-(3 guanylureido)-phenylacetamido]-penicillanic acid (BL-P1654) was evaluated against 117 clinical isolates of Pseudomonas aeruginosa, many of which were known to be resistant to both gentamicin and carbenicillin. BL-P1654 was two to eight times more active than carbenicillin against P. aeruginosa. However, all 28 highly carbenicillin-resistant isolates (minimal inhibitory concentration [MIC] > 500 mug/ml) were also highly resistant to BL-P1654. When an MIC of 32 mug/ml or less and a zone of inhibition of 12 mm or more by a 10-mug disk were used as criteria indicating susceptibility to BL-P1654, the false-resistance rate by the disk test was 10.6% and the false-susceptibility rate was 4.2%. The combination of BL-P1654 and gentamicin was synergistic against 45 of 70 isolates of P. aeruginosa tested, but synergism was demonstrated against only 4 of 24 highly gentamicin-resistant (MIC > 63 mug/ml), 1 of 12 highly BL-P1654-resistant (MIC > 250 mug/ml) isolates, and none of nine isolates highly resistant to both of these antibiotics.


Primaquine diphosphate: inhibition of Newcastle disease virus replication. The response of Newcastle disease virus replication to primaquine, an antimalarial drug, was examined in chicken embryo cells (CEC). Virus-induced hemadsorption was completely inhibited by 250 mug of primaquine per ml. At lower concentrations, hemadsorption inhibition was dose dependent. Primaquine retarded virus-induced redistribution of receptor sites on the host cell plasma membrane as shown by the failure of infected, drug-treated CEC to be agglutinated with concanavalin A. The production of infectious progeny virus was substantially inhibited by the addition of primaquine at various times postinfection. When the drug was added early in the virus replication cycle, viral ribonucleic acid (RNA) synthesis was inhibited; however, when the drug was added late in the cycle, stimulation of RNA synthesis was observed. Primaquine was also shown to retard the incorporation of [(14)C]amino acids into proteins of virus-infected CEC. We suggest that the major role of primaquine is inhibition of protein synthesis; this results in changes in: hemadsorption, redistribution of lectin receptors, release of progeny, and virus-induced RNA synthesis.


Single-dose daily gentamicin therapy in urinary tract infection. Patients with urinary tract infection were treated for 8 to 15 days with one daily intramuscular injection of 160 mg of gentamicin or 60 or 80 mg every 8 h. Ten of 11 patients treated with one injection daily were cured as compared with 8 of 10 patients treated with three injections daily. Urinary concentrations of gentamicin were 3.2 to 600 mug/ml in all 8-h collections in patients receiving one injection daily and were 22 to 440 mug/ml in all 8-h collections in patients receiving three injections daily. The group treated once daily demonstrated a significant but reversible increase in mean serum creatinine concentration and decrease in mean creatinine clearance during therapy as compared with no change in the group treated with three injections daily. Decreases in renal function were correlated with higher milligram per kilogram doses and higher 1-h serum concentrations.


Binding of [14C]erythromycin to Escherichia coli ribosomes. Erythromycin binding to Escherichia coli ribosomes required K(+) and Mg(2+). Under optimal conditions, the dissociation constant for erythromycin binding to E. coli ribosomes was found to be 1.0 x 10(-8) M and 1.4 x 10(-8) M at 24 C and 5 C, respectively. One molecule of [(14)C]erythromycin was bound to each 70S ribosome at equilibrium. Binding of erythromycin to ribosomes was rapid and reversible. The specific rate constants for the forward and reverse reactions were 1.7 x 10(7) liters per mol per min and 0.15 per min, respectively.


Effect of erythromycin analogues on binding of [14C]erythromycin to Escherichia coli ribosomes. The relative ability of 44 erythromycin analogues to bind to ribosomes was determined by their effect on [(14)C]erythromycin binding to Escherichia coli ribosomes. The association and dissociation constants of each of these erythromycin derivatives were determined as well as their interaction coefficient for their binding to ribosomes. Substitutions were made on various portions of the erythromycin molecule with retention of substantial activity as measured by inhibition of [(14)C]erythromycin binding to ribosomes. Since the effect of erythromycin analogues on [(14)C]erythromycin binding to ribosomes provides a relatively sensitive assay for these compounds, erythromycin analogues with relatively little affinity for ribosomes could be detected. Compounds with association constants of 10(4) M(-1) were detectable; the association constant for erythromycin binding to ribosomes was approximately 10(8) M(-1). Thus, compounds with 0.0001 the association constant of erythromycin were detectable. This assay could be used alone or in conjunction with microbiological assays for primary screening of active analogues or other compounds which interfere with [(14)C]erythromycin binding to ribosomes. It permits an estimate of the general activity of compounds rapidly and directly. Variables such as metabolic modifications of the compounds and permeability are excluded. The present assay reflects the ability of the compounds to interact directly with their target organelle and may serve as a useful adjunct in developing new compounds.


Correlation of effects of erythromycin analogues on intact bacteria and on [14C]erythromycin binding to Escherichia coli ribosomes. The dissociation constants for binding to ribosomes from Escherichia coli and concentrations at which 50% inhibition of [(14)C]erythromycin binding to ribosomes occurred were determined for 45 erythromycin analogues. These values were correlated with their antibacterial activities against Bacillus subtilis. Compounds which bound to ribosomes best showed the greatest activities; those which were poorly bound to ribosomes showed little or no antibacterial activity. The ribosomal binding assays therefore reflected the general antibacterial potential of the erythromycin analogues.


Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin. Among gram-negative bacilli isolated from burn wound cultures, some strains of Enterobacteriaceae were resistant to tobramycin (minimal inhibitory concentration [MIC]>/= 20 mug/ml) but susceptible to gentamicin (MIC </= 5 mug/ml). One Klebsiella pneumoniae and two Enterobacter cloacae strains were selected for studies on their mechanisms of resistance to aminoglycoside antibiotics. Resistance to high concentrations of tobramycin (MICs of 25 to 50 mug/ml) was conjugally transferred to a susceptible Escherichia coli strain at rates of 1.2 x 10(-4) to 2.8 to 10(-4) per donor cell, suggesting that resistance is controlled by R factors. Resistances to tobramycin, kanamycin, and neomycin were cotransferred. Enzymatic activities were present that acetylated tobramycin, gentamicin, and kanamycin in osmotic lysates from the donor and transcipient strains. Enzymatic adenylylation of these aminoglycosides was not observed. The aminoglycoside-acetylating activities from K. pneumoniae and E. cloacae resembled kanamycin acetyltransferase (KAT) in their specificity for aminoglycoside substrates. Not all isolates of bacteria that produce KAT are resistant to tobramycin, but the factors that determine susceptibility or resistance to tobramycin in KAT-producing bacteria have not yet been established.


Rapid, specific microbiological assay for amikacin (BB-K8). The emergence of a strain of Providencia stuartii resistant to multiple antibiotics with the exception of amikacin provided a test organism for a microbiological assay for this new semisynthetic aminoglycosidic aminocyclitol. Results can be read at 4 h and are specific for amikacin. The resistance of P. stuartii to all currently used antibiotics allows the utilization of this technique in the presence of other concurrently administered antibiotics and therefore eliminates the need for their inactivation in the assay procedure. The rapidity, specificity, and simplicity of this microbiological assay may provide a technique for routine clinical monitoring of patients on therapeutic regimens and could be utilized by institutions unable to perform the radioimmunoassay or radioassay techniques.


Use of available dosage forms of cephalexin in clinical comparison with phenoxymethyl penicillin and benzathine penicillin in the treatment of streptococcal pharyngitis in children. The effectiveness of cephalexin, an oral cephalosporin using a dosage equivalent to available capsular dosage forms, was studied in relation to the effectiveness of phenoxymethyl penicillin and benzathine penicillin in the treatment of 128 patients with beta-hemolytic streptococcal pharyngitis, all but six of whom had group A streptococci isolated from throat cultures. Approximately one-half, 66 patients, received cephalexin for 10 days; 34 patients received phenoxymethyl penicillin for 10 days; and 28 patients had a single injection of benzathine penicillin. There were four treatment failures determined bacteriologically post-therapy, two in the cephalexin treatment group and one each in the oral penicillin and intramuscular penicillin groups. Similar cure rates of 96.7, 97.1, and 96.4% were computed for the respective treatment regimens. Whereas intramuscular benzathine penicillin remains the regimen of choice in most instances, cephalexin appeared to be as effective as oral penicillin in the elimination of group A streptococci from the pharynx when oral treatment was desired for streptococcal pharyngitis.


Post-exposure prophylaxis of murine rabies with polyinosinic-polycytidylic acid and chlorite-oxidized amylose. Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 mug each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.


Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea. Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).


Isolation and characterization of a kanamycin resistance plasmid from Staphylococcus aureus. A circular covalently closed duplex deoxyribonucleic acid plasmid carrying genes for resistance to kanamycin/neomycin has been identified in Staphylococcus aureus E419. The plasmid has a molecular size of 9.2 x 10(6) daltons and can be transduced into or can transform competent susceptible strains of S. aureus to kanamycin/neomycin resistance.


Inhibition of herpesvirus replication by marine algae extracts. Extracts from two species of marine red algae, Cryptosyphonia woodii and Farlowia mollis, specifically inhibited herpes simplex virus replication in vitro.


Comparison of in vitro antibacterial activities of gentamicin and verdamicin. The in vitro activities of verdamicin and gentamicin were studied in parallel against 1,049 bacterial isolates. Verdamicin demonstrated activity similar to that of gentamicin against members of the family Enterobacteriaceae and against Pseudomonas aeruginosa at 2 and 8 mug/ml, respectively. Proteus rettgeri and Providencia stuartii were notably more susceptible to verdamicin. The new aminoglycoside was also highly active against staphylococci but was not effective against group D streptococci.


The evolution of mitosis and the eukaryotic condition.


On the evolutionary origin and possible mechanism of colchicine-sensitive mitotic movements.


Phosphagens and molecular evolution in worms.


Thermodynamic correlates of evolution.

Thermodynamic correlates of evolution.


Experimental alterations of the bound state of cerebral lysosomal enzymes.


Effect of steroid on enzyme response to cold injury in rat brain.


Multiple sclerosis among Orientals and Caucasians in Hawaii.


Contraction times and fiber types in patients with progressive muscular dystrophy.


The future of A-mode midline echoencephalography. The development of automated techniques.


The EEG in hypercalcemia.

The EEG in hypercalcemia.


Myeloneuropathy with abdominal disorders in Japan. A clinical study of 752 cases.


Lumbosacral traumatic meningocele. Report of a case.


Solid solitary aspergillotic granuloma of the brain. Report of a case due to Aspergillus candidus and review of the literature.


Myelopathy of "obscure" etiology--nutritional syndrome. A clinicoanatomic study.


Remittent peripheral neuropathy and cerebellar degeneration complicating lymphosarcoma.


Bacterial cerebral vasculitis.

Bacterial cerebral vasculitis.


Rhinosporidiosis in Raipur. A clinico-pathological study of 348 cases.


The sensitisation of T2 bacteriophage to visible light by 5-bromodeoxyuridine (BUdR): a possible technique for isolating conditional lethal (Ts) mutants.


Detection of Vibrio parahaemolyticus, non agglutinating (NAG) vibrios and Aeromonas species from cold blooded animals in Calcutta.


Some observations on the taxonomic position of the vibrios isolated in Marathwada.


Bacteriological study of pyoderma.

Bacteriological study of pyoderma.


Secretor status of two endogamous groups of Gujarat.


Granular cell tumours of the stomach.

Granular cell tumours of the stomach.


Study of left auricular appendage of Indians operated for mitral stenosis of rheumatic origin.


Amyloidosis: fluorescence microscopic study.


Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin. CM-55 is a synthetic analogue of the antibiotic cerulenin with the chemical structure of 2, 3-dodecenyl-4-oxo-dimethyl amide. This compound inhibited the growth of Saccharomyces cerevisiae ATCC 12341 and inhibited protein and lipid synthesis by 91 and 95%, respectively, at a concentration of 50 mug/ml (2.1 x 10(-4) M). The inhibition of protein synthesis was associated with the partial reduction of ribonucleic acid synthesis and leucine transport. The mechanism of inhibition of lipid synthesis was further investigated in a cell-free extract of the yeast. CM-55 inhibited the incorporation of [(14)C]acetyl Coenzyme A (CoA) into both fatty acid (FAF) and non-saponifiable fractions (NSF). However, it did not inhibit [(14)C]malonyl CoA incorporation into FAF and only slightly inhibited [(14)C]mevalonate incorporation into NSF. The activity of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase was inhibited more strongly than the incorporation of [(14)C]3-hydroxy-3-methylglutaryl CoA into NSF; this could account for the CM-55 inhibition of [(14)C]acetyl CoA incorporation into NSF.


Variations of retinal and cortical on and off responses to weak and strong chromatic stimuli in the rabbit.


Management of total anomalous pulmonary venous drainage in early infancy.


The adjuvant activity of Bacillus subtilis and subtilisin.


Immunologic characterization of serum factors responsible for cold urticaria.


Evaluation of IgE tests in an allergy practice.


Hypertension detection by dentists. A Bergen County, New Jersey pilot project in public health.


Rhodanese activity in chloroplasts.

Rhodanese activity in chloroplasts.


Policy statement of the Michigan Dental Hygienists' Association.


Primary teeth--potential esophageal foreign bodies.


The investigation of linkage between a quantitative trait and a marker locus.


The role of the department of dentistry in a modern paediatric teaching hospital.


Arrangement and rearrangement of cell surface antigens in a fluid plasma membrane.


Differentiation and the cell surface; illustrations from work with T cells and sperm.


The diagnosis, pathogenesis and treatment of Whipple's disease--illustrated by two cases.


Phthiriasis palpebrarum.

Phthiriasis palpebrarum.


In vivo staining properties of oral cancer.


Uptake of gold by collagen in gold therapy.


The staining and refractive properties of bone.


Studies of the cytochemistry of nucleoproteins. IV. Characterization of a granular form of ribonucleoprotein in the cytoplasm.


Adenocarcinoma and proliferative hyperplasia of the prostate gland in female Rattus (Mastomys) natalensis.


In vitro studies of the interactions of PuIV with blood proteins.


Iodine-129 as a "nonradioactive" tracer.


Seasonal variations in gamma globulin levels in neonatal market calves.


Endocrine investigations into mongolism.


A method for electron microscopic localization of aryl-sulphatase.


Evaluation of a nasal decongestant. Oxymetazoline hydrochloride (Afrin).


Combined antibacterial adsorbent treatment of simple acute diarrhea.


Ulcerative colitis and pregnancy.

Ulcerative colitis and pregnancy.


Amoebic gel-diffusion precipitin-test. Clinical evaluation in amoebic liver abscess.


Effect of dipyridamole on human platelet behaviour.


Experimental eosinophilia. 8. Cellular responses to altered globulins within cutaneous tissue.


Skin-sensitizing antibodies in serum sickness. Association of reaginic activity with gamma-2- and gamma-im-globulins.


Potassium, glucose, and insulin in treatment of myocardial infarction.


Hypergammaglobulinemia--the role of the immunoglobulins (gamma G, gamma A, gamma M).


Diagnosis of urinary infection by suprapubic bladder puncture.


Complications of cardioversion.

Complications of cardioversion.


Supraclavicular subclavian venepuncture and catheterisation.


Superficial biopsy of a rectal and a duodenal polyp. Two incorrect microscopical diagnoses.


Automatic peritoneal dialysis with a simple cycling machine.


Nerve endings of the lemur (Lemur fulvus rufus).


Increased venous pressure and edema in the lower extremities secondary to urinary retention.


Persistence of rubella antibody with and without embryopathy. A follow-up study of children exposed to maternal rubella.


Metabolism of benzene hexachloride isomers and related compounds in vitro. II. Purification and stereospecificity of house fly enzymes.


Thyrotoxicosis during pregnancy.

Thyrotoxicosis during pregnancy.


Iodination in relation to thyroglobulin maturation and subunit aggregation. Noniodinated subunits of thyroglobulin can aggregate, but iodination of the aggregate is required for its stabilization (maturation). Rat-thyroid slices incorporate amino acids into subunits, but cannot form mature thyroglobulin from the newly synthesized subunits. This defect leads to an accumulation of 16S and 12S proteins, although the preexisting thyroglobulin is 19S. Accumulation of 16S and 12S proteins can be produced in rat thyroids by the administration to the animals of a thiocarbamide derivative, methimazole. Upon withdrawal of methimazole, iodination of the 16S and 12S proteins proceeds, and 19S protein appears.


Goitrogenic hypothyroidism in feeder lambs.


Observations on the acid glycosaminoglycan (mucopolysaccharide) content of the matrix of aging cartilage.


On the possible role of autoimmunization in liver cirrhosis.


On the mechanism of sequence iron-hematein stains.


Animistic thought in civilized adults.

Animistic thought in civilized adults.


Relationship between the calculus present on teeth and stainable dental plaque.


Corticosteroids and allergic rhinitis.

Corticosteroids and allergic rhinitis.


Afrin and other nasal decongestant drugs.


Symbolism and the creative process of art.


Stone as a symbol in Apache mythology.

Stone as a symbol in Apache mythology.


The vulture as mother symbol: a note on Freud's Leonardo.


Cholesterol esterases of the silkworm Bombyx mori L.


Regions of the rabbit's heart atrio-ventricular node at which impulse propagation becomes critical.


Action potential from A. V. node transitional cells.


Excitability changes in non-specific thalamic nuclei during striatal depression in the rat.


Organic contribution to intracellular osmolarity in rabbits.


Optimum length for contraction of rat circulated limb muscles.


Seasonal variations in the nature of neurotransmitters in a frog vagus-stomach muscle preparation.


Effects of glucagon on the metabolism of rat mitochondria.


Gamma motor system in spinal shock.

Gamma motor system in spinal shock.


Modifications for calloso-cortical response by sleep.


Requirement of thiol groups in methane production by rumen bacteria.


Operational thought and symbolic imagery.


Protein-losing enteropathy. Report of case and isotope studies.


The use of labeled antibodies in ultrastructural studies.


Case report: lupus-like syndrome with positive Hargrave phenomenon induced by pronestyl therapy: analysis of the test.


Studies on the Gm and InV factors in Japanese individuals and families.


The staining of acid mucopolysaccharides in oral mucous cysts.


Immunopathological data on pathogenesis of burn disease and glomerulonephritis.


Sporadic occurrence in Jamaica of neoplasms resembling Burkitt's tumour.


Reversible non-metastatic liver-cell dysfunction and thrombocytosis from a hypernephroma.


Susceptibility of man to Pseudomonas aeruginosa.


A fluid-support mattress and seat for the prevention and treatment of decubitus ulcers.


Bladder tumours in industry.

Bladder tumours in industry.


Mental symptoms in vitamin-B-12 deficiency.


Yellow fever.

Yellow fever.


Persistent fibrin.

Persistent fibrin.


Surgical aspects of innervation of the diaphragm.


Paediatrics and the undergraduate curriculum.


Halothane.

Halothane.


Amitriptyline poisoning.

Amitriptyline poisoning.


Heparin and osteoporosis.

Heparin and osteoporosis.


Myocardial infarction following radiation.


Combined chemotherapy and radiotherapy in carcinoma of the lung.


Lupoid hepatitis.

Lupoid hepatitis.


The influence of fixation upon staining according to Klüver and Barrera.


Observations on sudanophilic simple and bound lipids in three species of termite flagellates.


Alexander Forbes.

Alexander Forbes.


Correlation between the morphology and potential field of a spinal motor nucleus in the cat.


Effects of cryogenic thalamic lesions on the somesthetic evoked response in man.


Long duration periodic changes in excitability of penicillin spike foci: cyclical spike driving.


Cobalt-induced seizures in the cat.

Cobalt-induced seizures in the cat.


Electrical activity of the frog brain during electrically induced seizures. A comparative study of the spike and wave complex.


Effect of whole brain cobalt-60 gamma irradiation on cortical arousal in the burro.


Spontaneous slow modulation of flicker-evoked response in human brain.


Effects of an acute increase of intracranial pressure upon the electroencephalogram.


A method of electrode placement with a view to topographical research. II. Practical application.


A technique for recording and integrating multiple unit activity simultaneously with the EEG in chronic animals.


The chemical and histochemical properties of Alcian Blue. I. The mechanism of Alcian Blue staining.


Procainamide hydrochloride and lupus erythematosus.


The chemical and histochemical properties of Alcian Blue. 3. Chemical blocking and unblocking.


Ventricular localization of bound gamma globulin in idiopathic disease of the myocardium.


Antibodies and immunoglobulins. I. Structure and function.


Synthesis of 2-aryl-3-phenylindones and a new simple route to pentaphene.


A synthetic approach to the 9(10:19)abeo-pregnane system, involving carbocyclic ring cleavage during Wolff-Kishner reduction.


Azasteroids IV. Synthesis of 13-aza-18-norequilenin methyl ether.


Dustanin: a new pentacyclic triterpenoid as a fungal metabolite.


Constitution and function of polyribosomes of poliovirus-infected HeLa cells.


Some physical and chemical properties of cucumber mosaic virus (strain Y) and of its isolated ribonucleic acid.


Studies on "early" enzymes in HeLa cells infected with vaccinia virus.


Thin skin healing.

Thin skin healing.


The effects of an antihistamine (promethazine) on the reaction of tendons to trauma (a histological study).


Treatment of extensively burned patients with freeze-dried homologous skin (a long-term appraisal of the results).


Transplantation of knee joint (experimental study).


The tasks of the tissue bank in clinical transplantations.


Homotransplantation of arteries based on total blood exchange to overcome tissue incompatibility (experimental study).


Determination of the condition of vascularization of pedicle skin grafts (Gillies-Filatov) by the thermoelement.


Study of the cervical lesions in  cervical biopsy specimens.


A scheme for the histopathological diagnosis of tumours of the nervous system during operations.


Osteomyelitis of the spine following needle biopsy of the prostate.


Development of a response-recognition training film in tennis.


Neurolemmomas. A correlative study with silver carbonate techniques and electron microscopy.


Colloidal gold studies in multiple myeloma.


The effect of actinomycin on regeneration processes in amphibians.


Audiovisual aids for periodontal patients.


Bilateral adrenalectomy for advanced mammary cancer: 9-year review of 84 cases.


The immune globulins.

The immune globulins.


Management of patients with acquired malignant esophagorespiratory fistulas.


The assessment of thyroid function.

The assessment of thyroid function.


The management of thyrotoxicosis during pregnancy.


The doubtfully malignant prostate.

The doubtfully malignant prostate.


Sleep-inducing mechanisms in the brain stem.


Variability and redundancy in the cerebral cortex.


Changes of cortical neuronal activity and EEG during hypoglycemia.


Cortical synchronization and sleep patterns in acute restrained and chronic behaving cats induced by basal forebrain stimulation.


Sleep induced by electrical or chemical stimulation of the forebrain.


Specific and unspecific influences on the olfactory bulb.


Some structuro-functional correlates of development in young cats.


Some motivational effects of electrical and chemical stimulation of the brain.


Effect of brain stimulation on task-free situations.


Effects of diencephalic and mesencephalic lesions upon afferent impulses in the central sensory pathways.


Properties of cerebral somatic evoked responses in unanesthetized Cebus monkey.


Information carrying characteristics of brain responses.


The effects of barbiturate anesthesia upon human somatosensory evoked responses.


The action of convulsants on neuronal and gross wave activity in the thalamus and in the cortex.


Influence of the states of awareness upon sensory evoked potentials.


Moderating and activating systems in medio-central thalamus and reticular formation.


A new tray for improved Giemsa staining of blood films.


Biochemical consequences of supernumerary chromosome subtype in mongolism.


Suppression of lactation. A  double-blind trial.


Retinoblastoma. Report on 19 patients treated with radio- therapy.


Gold--an occult cause of low serum protein-bound iodine.


The acute thyroid response to emotional stress.


Enzyme activities in relation to the charge patterns in living cells.


The basis of excitation and action potential in muscle and nerve.


Oxythiamine induced thiamine deficiency in the silkworm Bombyx mori L.


Influence of reserpine and of adrenolytic agents on the pulmonary arterial pressor response to hypoxia and catecholamines.


Composition of the ribonucleic acid of alate cabbage aphids Brevicoryne brassicae (L.).


Effect of prolonged starvation on weight and oxygen consumption of the earthworm, Lampito mauritii, in aquatic medium.


An assay procedure for nicotinamide-adenine dinucleotides in rat liver and other tissues.


A dynamic analysis of arterial blood pressure control systems.


Evidence for the presence of nucleotidebound amino acids or peptides in germinating peas.


Liver perfusion as a tool for biochemical research.


Vitamin D activity in normal human serum and serum proteins.


A study of the postextrasystolic T wave changes associated with interpolated premature ventricular beats.


Chemotherapy of breast cancer.

Chemotherapy of breast cancer.


Fine structure of cells forming the surface layer of the epidermis in human fetuses at fourteen and twelve weeks.


Ultrastructure of blastospores of Candida albicans after permanganate fixation.


The application of fuchsin--paraldehyde in total staining for evidencing the neurosecretory system of mammals in stereometric vision.


A study of the neurophysiological mechanisms of dreaming.


Conditioned and discriminatory responses in wakeful and in sleeping cats.


Mechanisms of instrumental conditioning.


Medical video recorder.

Medical video recorder.


Inexcitability of the brainbridge, McDowall and Harrison reflexes.


The relation of alternating contractility of the heart to the inotropic effects of rhythm.


Variability in the cardiac output of dogs, as estimated by radiocardiography.


Relationships between cardiac output, blood volume and body composition in chloralose anesthetized normal dogs.


Variations of serum alkaline phosphatase and plasma uric acid during child's growth.


Lipid metabolism in Rhizostoma.

Lipid metabolism in Rhizostoma.


Effect of thiouracil and/or thyroxine on hexosamine and hydroxyproline in blood and tissues of rats.


Substrate concentration and activity of the ribonucleases of pancreas and Phaseolus aureus.


Chlorogenase, a chlorogenic acid splitting enzyme from Aspergillus niger.


A new synthesis of some trinucleoside diphosphates.


The formation of o-coumaroyl-beta-glucoside from coumarin-2-14C in barley embryos.


A new thin-layer chromatography of phenolic acids and coumarins.


Chlorogenase, a chlorogenic acid splitting enzyme from Asperigillus niger.


Depressive influences by the olfactory bulb on the intrinsic excitability of the contralateral olfactory bulb.


Acid-base balance in cerebrospinal fluid during prolonged artificial hyperventilation.


The action of the first component of complement on cells sensitized with blood group antibody.


Effect of uracil mustard and several antitumor drugs on the primary antibody response in rats and mice.


Membrane-like structures within the sarcoplasmic reticulum.


Cytophotometric determinations of basic proteins of cell nucleic with basic dyes.


Precise localization of Renshaw cells with a new marking technique.


Spreading depression in the mammalian striatum.


Effects of starvation on the larval body composition and phosphorus metabolism in Tribolium confusum Duval.


Investigation on the carbon dioxyde reducing capacity of rumen bacteria and protozoa.


Orthodromic and antidromic components of responses evoked on the pericruciate cortex upon stimulation on the ventral medulla in chronic cats.


Adrenergic actions on heart rate, atrio-ventricular refractory  period and intraventricular conduction in dogs.


Serum electrolyte pattern of normal and scorbutic guinea pigs.


Angiocardiographic studies of pericardial disease.


Fibrinolysis and plasminogen levels in pregnancy and the puerperium.


Antigenic relationship of varicella-zoster and herpes simplex.


Acid-base control during exchange transfusion.


Blood-serotonin deficiency in Down's syndrome.


13-15 trisomy in eight cases of arrhinencephaly.


Sex of the foetus in antepartum haemorrhage.


Tuberculin reactions in malnourished children.


Expansion pressures and rupture pressures in the newborn lung.


Muscular dystrophy with a familial aminoaciduria of unusual pattern.


Lymphocyte RNA metabolism. Comparison between antigen and phytohaemagglutinin stimulation.


The search for causes of breast cancer.

The search for causes of breast cancer.


Herpes-simplex encephalitis.

Herpes-simplex encephalitis.


The control of syphilis.

The control of syphilis.


Immigration in the midlands.

Immigration in the midlands.


Recent mortality from breast cancer.

Recent mortality from breast cancer.


The public health in 1964.

The public health in 1964.


Phenelzine and trifluoperazine poisoning.


Pulmonary oedema after defibrillation.

Pulmonary oedema after defibrillation.


Side-effects of antiarthritic drugs.

Side-effects of antiarthritic drugs.


Dipyridamole and platelet behavior.

Dipyridamole and platelet behavior.


The importance of carnitine in the diet of larvae of Oryzaephilus surinamensis (L.) (Coleoptera: Silvanidae).


Radioimmunoassay of thyrotropin in human serum.


Effect of exogenous thyroxine on thyroid accumulation and secretion in euthyroid subjects.


Iodide repletion test in an endemic goiter area of Central Italy.


Psychogenic paroxysmal cardiac arrhythmias. Contents of mental events, age and patterns of arrhythmias.


Remission of hyperthyroidism (Graves' disease) and altered pattern of serum-thyroxine binding induced by prednisone.


Chromosomal anomalies in dysplasia, carcinoma-in-situ, and carcinoma of cervix uteri.


Polycythaemia vera.

Polycythaemia vera.


Folate deficiency and neurological disease.


Correction of iodine deficiency in New Guinea natives by iodised oil injection.


Effect of hexamethonium on gastric hypersecretion.


Multiple emulsions. A new form of mineral-oil antigen adjuvant.


New epidemic strains of Staphylococcus aureus.


Actinomycin and nucleic acid function.

Actinomycin and nucleic acid function.


Neurosurgical implications of metastatic carcinoma.


Transmission of direct cortical responses.


Intracellular phenomena in electrically induced seizures.


Effect of sensory stimuli on single unit activity in the posterior hypothalamus.


Unit analysis of mesencephalic reticular formation control of spinal cord neurons.


Excitability cycle of the visual cortex during sleep and wakefulness.


The morphology of the spike-wave complex.


Recovery of the electro-oculogram after total ablation of the retina in monkeys.


EEG activation after intravenous amitriptyline.


Survey of lead in the atmosphere of three urban communities: a summary.


Relationship of EEG background rhythms to photic evoked responses.


Resolution and stability in the autospectra of EEG.


A simplified cannula system for implanting and injecting chemicals into the brains of small animals.


Instantaneous and 30-90 minute reactions of cells to injury.


Histochemical evidence for the presence of lipid on the chromosomes of animal cells.


A new immuno-chemical technique for electron microscopic study of nuclear structure using human antinuclear antibodies.


Cytoplasmic basic proteins in the oocytes of three species of molluscs.


Diagnosis of hyperthyroidism by external liver counting: correlation between external scintillation counting of the liver and plasma protein-bound iodine-131.


Tape recorded conversations: a method to increase patient teaching.


Teaching hypnosis with video tapes.

Teaching hypnosis with video tapes.


Slides plus recorded commentary instruct food service workers.


Haemophilus influenzae and chronic bronchitis.


Phenomenon of iodide inhibition in various states of thyroid function with observations on one mechanism of its occurrence.


Medical privilege in English Law.

Medical privilege in English Law.


The family home.

The family home.


Rights of privacy in medical practice.

Rights of privacy in medical practice.


Discussions on general practice.

Discussions on general practice.


Aetiology of childhood leukaemia.

Aetiology of childhood leukaemia.


Potassium chloride and intestinal ulceration.


James Kirkwood Slater.

James Kirkwood Slater.


Frank Edward Tylecote.

Frank Edward Tylecote.


Alexander Thomas Glenny.

Alexander Thomas Glenny.


Observations on the hexokinase activity in intact human erythrocytes.


Establishment of a tissue culture strain JTC-14 from actinomycin-induced ascites sarcoma, and its biological characters.


Site of multiplication of human leprosy bacilli inoculated into the foot-pads of mice.


Tumors of the head and neck--the who, when and how of treatment.


Thrombectomy for massive venous thrombosis.


Inv(a) serum factor in Venezuelan Indians.


Single unit analysis of cortex-caudate connections.


Chronic implantation of multiple macroelectrodes. A technique for mapping auditory neocortex in unanesthetized cats.


The aqueous humor drainage mechanism in the cynomolgus monkey (Macaca irus) with evidence for unconventional routes.


Production and drainage of aqueous humor in the cynomolgus monkey (Macaca irus).


The diagnosis and treatment of Whipple's disease.


Bronchopulmonary effects of tobacco and related substances. II. Bronchial arterial injections of nicotine and histamine.


A comparison of the native and monomer forms of macroglobulin from pathological human serum with particular reference to electrophoretic mobility differences.


Incorporation of sarcosine into the actinomycins synthesized by Streptomyces antibioticus.


Immunoglobulins in mink ranchers associated with Aleutian disease.


Molecular forms of lactic dehydrogenase of fava bean-sensitive subjects.


Factors influencing the hexokinase activity in hemolysates.


Periodic acid Schiff reaction positive material in diabetic and nondiabetic buccal mucosa.


Tetanus immune globulin (human) in prophylaxis against tetanus.


Psychoanalyst subpoenaed.

Psychoanalyst subpoenaed.


Survey of blood levels of apparently healthy Filipinos of all ages. 2. Serum proteins: albumin, alpha-1, alpha-2, beta and gamma globulins .


The "lemmocyte" in peripheral-nerve tumors.


The influence of occupational exposure to chemical agents and x-rays on the leucocyte alkaline phosphatase activity.


Deoxyribonucleic acid content of antibody-containing cells in the rat lymph node.


Structure of amyloid fibrils after negative staining and high-resolution electron microscopy.


Metabolic changes in chick fibroblasts after infection with Newcastle disease virus.


Juxta glomerular apparatus staining with thioflavine T fluorochrome, and its confusion with amyloid.


A comparative family study of rheumatoid arthritis and systemic lupus erythematosus.


Anaphylactic tests in model tumour antigen investigations.


Palliative management of the patient with advanced malignant disease.


Dissociation of skin homograft tolerance and donor type gamma globulin synthesis in allogeneic mouse radiation chimaeras.


Significance of incomplete antibody in tuberculous allergy.


Simplified method for fluorescent antibody staining of tissue cultures.


The role of the ego in the recovery of early memories.


Electron microscopic examination of wild cucumber mosaic virus in negatively stained crude preparations.


Conductivity of the cerebral cortex after circulatory arrest at body temperatures from 37 degrees C to 18 degrees C.


Metabolism of dl-carnitine and croton-betaine in the chick embryo.


Cortical responses evoked by stimulation of the optic pathways during natural sleep and during arousal.


The influence of spinal transection on central nystagmus.


Phosphorylcreatine and ATP changes during shortening and lengthening of stimulated muscle.


Veratrine and sympathetic postganglionic transmission.


The purine sequences of yeast ribonucleic acid.


Evoked sensory responses of somatic origin in the lateral geniculate body.


The control of glycolysis in erythrocyte by active cation transport.


Irreversible inhibitors of glucose transfer in human erythrocytes.


Graves' disease without hyperthyroidism.


Serum immune globulin concentrations in acute leukemia during intensive chemotherapy.


Anticoagulant malingerers (the "dicumarol-eaters").


Demonstration of the exposure of new antigenic determinants following antigen-antibody combination.


Chloride, potassium and water content of apical dendrites and their changes after circulatory arrest, at body temperatures from 37 degrees C to 20 degrees C.


The uses of gamma globulin in prophylaxis and treatment.


Chelatable iron in senile siderocalcification of the human brain.


An evaluation of the medical management of thyrotoxicosis in pregnancy.


Visceral larva migrans syndrome: clinical characteristics and immunologic studies in 51 patients.


Incorporation of deoxribonucleic acid by HeLa cells during various phases of the cell cycle.


Studies of the natural history and prevention of rubella.


Rubella epidemic, 1964: effect on 6,000 pregnancies.


Studies on congenital rubella. Preliminary results on the frequency and significance of presence of rubella virus in the newborn and the effect of gamma-globulin in preventing congenital rubella.


Congenital rubella. Clinicopathologic, virologic, and immunologic studies.


Anaemia of rheumatoid arthritis and iron therapy.


rheumatoid factors in primary and reactive macroglobulinaemia.


Immunological studies on Behçet's syndrome.


Detection of preformed venous thrombi in dogs by means of I-131-labeled antibodies to dog fibrinogen.


Heterogeneity of the peptide chains of gamma-globulin.


Effect of serum complement on systemic  heterophil anaphylaxis of mice.


Transfer rates of gamma globulin between cerebrospinal fluid and blood plasma (results obtained on a series of multiple sclerosis patients).


Purposes of medicine.

Purposes of medicine.


Large doses of penicillin in the prevention of surgical wound infection.


Capillary loss of radio-iodinated serum albumin in diabetics.


Protein intolerance with deficient transport of basic aminoacids. Another inborn error of metabolism.


Homograft interaction in the test-tube.

Homograft interaction in the test-tube.


Pharmacological study of high molecular anticoagulants.


Organ-specific autoantibodies in reagin-containing sera from allergic patients.


Histamine-infusion test.

Histamine-infusion test.


Oesophageal reflux after abdominal vagotomy.


Congenital rubella syndrome.

Congenital rubella syndrome.


Salmonella edinburg infection in children. A protracted hospital epidemic due to a multiple-drug-resistant strain.


Kuru as a model of hormonally programmed central nervous degeneration.


Smoke and nasopharyngeal cancer.

Smoke and nasopharyngeal cancer.


Epidemiology of hepatitis.

Epidemiology of hepatitis.


Experimentally induced myasthenia-like syndrome and thymomas.


Lymphocyte culture and tissue typing.

Lymphocyte culture and tissue typing.


Nobel prize for medicine.

Nobel prize for medicine.


Tuberculin tine test.

Tuberculin tine test.


Danger at home.

Danger at home.


Education of the immigrant child.

Education of the immigrant child.


Sterilisation of surgical instruments in a "flash" autoclave.


The health of Israel.

The health of Israel.


Amitriptyline and imipramine poisoning.

Amitriptyline and imipramine poisoning.


Tranylcypromine in multiple sclerosis.

Tranylcypromine in multiple sclerosis.


A case of myeloma with a pathological protein in the alpha-1-globulin fraction.


Exclusive occurrence of K chains in isolated cold haemagglutinins.


The role of visual education in patient education.


Antithyrotoxic acitivty of hemoglobin in the rat.


Insurance. Two year report: "Loss of occupational use of hand" protection widely supported.


The Philadelphia General Hospital externship program.


The effect of strontium chloride on peripheral nerve in comparison to the action of "stabilizer" and "labilizer" compounds.


Dentistry should be demonstrated.

Dentistry should be demonstrated.


Visually evoked response correlates of perceptual masking and enhancement.


Changes in patterns of the human electroencephalogram during fluctuations of perception of stabilized retinal images.


Changes in the amplitude of photically evoked potentials by a conditioned stimulus.


Effects of carotid compression on cerebral metabolism and electroencephalogram.


Electro-cerebral  activity in schizophrenics and non-psychotic subjects: quantitative EEG amplitude analysis.


Frequencies of slow potential oscillations in the cortex of cats.


The electroencephalographic hyperventilation response in migraine.


Visual evoked potentials in subjects with congenital aniridia.


A stereotaxic instrument for man.

A stereotaxic instrument for man.


Aperiodic stimulus presentation with a closed-loop magnetic tape averaging system.


Nasopharyngeal electrode placement.

Nasopharyngeal electrode placement.


A direct histo-chemical method to identify the effect of coagulation in brain tissue.


A simple method for filling and storing glass micro-electrodes.


An inexpensive adjustable electrode for chronic implantation.


Serodiagnosis of rheumatoid arthritis based on inhibition of anticomplementariness of denatured fraction II.


Heterogeneity of rat immunoglobulins.

Heterogeneity of rat immunoglobulins.


Antibodies and immunoglobulins. II. Normal development and changes in disease.


Can chemotherapeutic perfusion of pelvic viscera palliate patients with advanced or recurrent cervical cancer?


Increased bishydroxycoumarin requirements in patients receiving phenobarbital.


Adjuvant cancer chemotherapy. Development of a dosage schedule for the adjuvant cancer chemotherapy in surgical cases.


Obliterative arterial disease of the lower limbs. IV. Evaluation of long-term anticoagulant therapy.


Phasic dimensional changes in the left ventricle.


Reflex activity in spinal cats with postasphyxial rigidity.


Bradykinin and anaphylactic shock in dogs, guinea-pigs and rabbits.


Histological differentiation of the retina and electro-retinographic critical-fusion-frequency.


Site of action of L-alanine and D-glucose on the potential difference across the intestine.


The separation of mono-, di- and trinucleotide sequences from the pancreatic ribonuclease digest of the ribonucleic acid of the bacteriophage MS2.


The distribution of purine sequences in the ribonucleic acid of the bacteriophage MS2.


The presence in plant extracts of aspartic acid bound to a uracil ring.


Purification and properties of carboxymethyl cellulase from Aspergillus niger.


Intracellular Cl concentration in frog ventricle as a function of the extracellular Na and Cl concentration.


Influence of different fixed heart rates on the adaptation of the cardiac output to muscular exercise.


The phosphorylase activity of the heart in acute hypoxia.


Fractionated determination of estrone, estradiol-17 beta and estriol in human urine.


The explosive properties of ammoniacal-silver solutions.


A stain for myelin using solochrome cyanin.


Biosynthesis of highly labeled actinomycins.


Homograft inhibition by competing protein antigens in inbred mice.


Inhibition of the in vivo nephrotoxic antigen-antibody reaction by gamma globulin.


Urinary proteins in dog renal homografts.


Plasma protein electrophoresis in dogs bearing renal homotransplants.


Prostatic corpora amylacea and their calcification.


Immunochemical changes observed with shock.


Effect of microsurgical pituitary ablation on pancreatic secretion.


Alteration of acetylicholinesterase in the cochlea.


Antistreptokinase titre in healthy adults.


Sclerosing cholangitis--a manifestation of systemic disease. Increased serum gamma-globulin, follicular lymph node hyperplasia, and orbital pseudotumor.


Incorporation of amino acids into polyribosome-associated protein in cytoplasmic extracts of poliovirus-infected HeLa cells.


Effect of actinomycin K on nucleic acid and protein synthesis in somatic cells in vitro.


Thrombotic complication of superior vena cava to pulmonary artery anastomosis.