Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6-hydroxydopamine. 1. Brain noradrenaline, dopamine and tyrosine hydroxylase were found in rat brain a few days before birth and increased progressively until reaching adult values. The most rapid period of growth for these substances seemed to occur between 7 and 18 days.2. The intracisternal administration of 6-hydroxydopamine to rats 7 days of age reduced concentrations of noradrenaline, dopamine, and tyrosine hydroxylase by 72 hours.3. The concentrations of noradrenaline, dopamine or tyrosine hydroxylase in rats that received 6-hydroxydopamine at 7 or 14 days of age remained markedly reduced when determined at adulthood, indicating that fibres did not continue to develop after the administration of this compound. The rats treated at 7 days also showed diminished concentrations of noradrenaline in heart.4. Rats injected with 6-hydroxydopamine at 7 days had reduced body weight as well as a reduction of some organ weights. This growth deficit was not observed in animals that received this drug at 14 days of age.5. The administration of ovine growth hormone to rats that received 6-hydroxydopamine at 7 days did not reverse the growth deficiency in these animals.


Clinical investigation of an antagonist at alpha- and beta-adrenoceptors-AH5158A. 1. The alpha- and beta-adrenoceptor blocking action of AH 5158A was investigated in man using the veins of the hand, the arterial bed of the forearm, and certain responses of the circulation as a whole.2. In the veins, locally infused AH 5158A resulted in specific and competitive antagonism of the constrictor response to locally infused noradrenaline and of the dilator response to isoprenaline.3. Brachial artery infusions of AH 5158A resulted in competitive antagonism of the arterial blood flow changes produced by local infusions of noradrenaline and isoprenaline.4. Systemic infusion of AH 5158A (0.5-0.9 mg/kg) produced clear blockade of the heart rate response to systemic infusion of isoprenaline. It also attenuated the response to exercise at 80 watts for 4 min; mean arterial pressure during exercise was reduced by 16% and heart rate by 18%. Blockade lasted at least 1 hour.5. AH 5158A caused small changes in arterial pressure and heart rate at rest supine, but had no effect on the response of pressure and rate to tilting.


Comparison of blockade at alpha-adrenoceptors by thymoxamine and phentolamine in peripheral arteries and veins of man. 1. The antagonism at alpha-adrenoceptors by thymoxamine and phentolamine of the response to noradrenaline was investigated in the limb veins and arteries of man.2. Brachial artery infusions of thymoxamine (40 mug/min) produced rises in resting arterial flow of up to 100%. When infused mixed with noradrenaline, thymoxamine (40 mug/min) attenuated the blood flow response to noradrenaline. Blockade was of a similar degree to that which occurred following a 10 min infusion of phentolamine (40 mug/min).3. Local intravenous infusion of thymoxamine (400-2,000 ng/min) mixed with noradrenaline attenuated the venoconstrictor response to noradrenaline. The degree of attenuation was similar to that seen after a 10 min infusion of phentolamine (500 ng/min). Blockade after thymoxamine did not last longer than 16 minutes. Neither thymoxamine nor phentolamine altered resting venous compliance.4. Local intravenous infusions of thymoxamine (500 ng/min) and phentolamine (500 ng/min) abolished the sympathetically mediated venoconstriction produced by overbreathing.5. Systemic injection of thymoxamine (0.1 mg/kg) did not block the reduction in forearm arterial flow produced by locally infused noradrenaline. In two out of three experiments, however, it produced some antagonism of noradrenaline induced venoconstriction. Systemic phentolamine (5 mg) blocked the effect of noradrenaline in the arterial bed, but antagonized its actions in the veins in only one out of three experiments.


Interaction of atropine-like drugs with dopamine-containing neurones in rat brain. 1. A variety of atropine-like drugs effective in the treatment of drug-induced extrapyramidal syndromes have been investigated with regard to their interaction with dopamine-containing neurones in rat brain.2. Under some conditions benztropine, trihexyphenidyl, atropine and ethopropazine significantly antagonized the chlorpromazine-induced increase in subcortical concentrations of homovanillic acid.3. Most of the atropine-like drugs investigated also decreased the turnover of dopamine in the subcortex as measured by following the disappearance of dopamine after administration of alpha-methyl-p-tyrosine.4. These findings are suggestive that an imbalance between a dopaminergic and cholinergic system might be closely linked to the pathogenesis of extra-pyramidal movement disorders.


Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues. The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.


Proceedings: Is thymoxamine a specific alpha-adrenoceptor blocking agent?


Proceedings: Failure to induce experimental hypertension in rats after intraventricular injection of 6-hydroxydopamine.


Proceedings: Alpha-adrenoceptor inhibition from indoramin in man.


Proceedings: Preliminary studies of Ro 3-3528, a beta-adrenoceptor-blocking agent, in man.


Time course studies of glucose-induced changes in glucose-6-phosphate and fructose-1,6-diphosphate content of mouse and rat pancreatic islets.


Alterations of hepatic enzyme activities in KK and yellow KK mice with various diabetic states.


Cross reactions of a panosyl-azoprotein conjugate with antipneumococcal horse sera.


Effect of cortisol on the level of pyridoxal phosphate-dependent enzymes in the rat liver: new supports for antagonism between female sex hormones and cortisol.


Effect of school water fluoridation on dental caries: interim results in Seagrove, NC, after four years.


1,4-Benzodioxanes as reversible and irreversible antagonists at adrenergic receptors.


Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. 3. Comparative studies in H35, HTC, MH1C1 and RLC cells. The ability of N(6), O(2)'-dibutyryl cyclic AMP (DBcAMP) to regulate a number of metabolic events in four lines of cultured rat hepatomas has been examined. Although dexamethasone induces tyrosine transaminase in all four lines, DBcAMP induces this enzyme normally only in H35 cells. A slight increase in transaminase activity was seen with MH(1)C(1) cells and HTC cells, but no effect was detectable in RLC cells. In contrast, phosphoenolpyruvate carboxykinase activity is increased by both agents in H35 and MH(1)C(1) cells, but neither had any effect in HTC or RLC cells. DBcAMP caused a rapid inhibition of the growth rate and DNA synthesis and an increase in protein content in both H35 and MH(1)C(1) cells but not in HTC or RLC cells. The effect of DBcAMP on DNA synthesis in MH(1)C(1) cells could be reversed by deoxycytidine as is also the case with H35 cells. The resistance of HTC and RLC cells to DBcAMP was not due to reduced uptake or deacylation as judged by studies with [(3)H]DBcAMP. The cyclic nucleotide appears to enter the cells by passive diffusion as the intracellular concentration approaches that in the medium within 30-60 min. Possible explanations for the differential responses observed are discussed.


1-Alkylamino-3-(2-thiazolyloxy)-2-propanols. A novel class of mixed myocardial beta-stimulants-beta-blockers.


Blockade by burimamide of the effects of histamine and histamine analogs on cardiac contractility, phosphorylase activation and cyclic adenosine monophosphate.


Effects of beta adrenergic blocking agents on plasma renin activity in the conscious rabbit.


Responses of psychiatric inpatients to the MacAndrew Alcoholism Scale.


Protocols for physician assistants. Management of diabetes and hypertension.


Enzyme response to prednisolone and dibutyryl adenosine 3',5'-monophosphate in human fetal liver.


Benzene metabolism in mouse liver microsomes.


The use of computers in ambulatory care: lessons from 3000 encounters.


NAD and NADP dependent isocitrate dehydrogenase and fumarate hydratase activities in normal human skin and in some maculosquamous diseases of the skin.


Editorial: Computer application to biophysics in Russia. An editorial describing aspects of the Fourth International Biophysics Congress and personal observations on Russia.


Hemodynamic and biochemical effects of a new positive inotropic agent. Antibiotic ionophore RO 2-2985.


Necrotizing angiitis: a report of two cases.


Conservation of tissue specificity after heterotopic transplantation of gingiva and alveolar mucosa.


MMPI characteristics of clergymen in counseling training and their relationship to supervisor's and peers' ratings of counseling effectiveness.


Cross-validation of a system for predicting training success of Medex trainees.


Personality characteristics of urban and suburban heroin abusers: more data and another reply to Sutker and Allain (1973).


Effects of convulsant and anticonvulsant drugs on the activity of some enzymes in the rat brain.


GVH-reactivity of rat lymphocytes sensitized in "mixed lymphocytes culture".


Certain aspects of drug binding to nonplasma proteins as illustrated by studies with cyclizine, chlorcyclizine, and polymyxin B.


Albumin transcapillary escape rate and plasma volume during long-term beta-adrenergic blockade in essential hypertension.


Metaproterenol, a potent and safe bronchodilator.


Reaction of drugs with nitrous acid as a source of carcinogenic nitrosamines.


Characterization of a peptidase from Diplococcus pneumoniae.


Responses of plasma glucose, free fatty acids and glucagon to cobalt and nickel chlorides by Gallus domesticus.


Responses of plasma glucose, free fatty acids, glucagon and insulin to synthalin A by Gallus domesticus.


Investigations into the mode of action of synthalin A in Gallus domesticus.


Extra-branchial pathways of salt exchange in a teleost fish.


Hyperthermia in heat-adapted female rats.


Studies on the adaptation of Xenopus laevis to hyperosmotic media.


Oxygen dissociation and content of blood from Alaskan burbott (Lota lota), pike (Esox lucius) and grayling (Thymallus arcticus).


Influence of exogenous growth hormone and its antiserum on plasma free fatty acid level in the pigeon.


Seasonal variations and osmoregulation in the red blood cells of the diamondback terrapin Malaclemys centrata centrata (Latreille).


Some aspects of the hematology and immunology of the hibernating and nonhibernating woodchuck (Marmota monax).


The circannual variations of some of the hormones of the woodchuck (Marmota monax).


Intestinal disaccharidase activity of non-human primates. II. Lorisidae, Hapalidae, Cebidae.


The importance of the counter current oxygen multiplier mechanism in maintaining retinal function in the teleost.


Hemoglobin of the aquatic salamander, Cryptobranchus.


A study of some blood constituents of two species of mudfish.


Diurnal rhythm in serotonin of blood and pineals of chickens.


Geographic variation of thermal conductance in the house sparrow Passer domesticus.


Water and salt regulation in the antelope ground squirrel (Ammospermophilus leucurus).


Pineal gland: evidence for an influence on ethanol preference in male Syrian hamsters.


In vitro blood carbon dioxide of the rainbow trout (Salmo gairdneri).


"Hepatopancreas"?

"Hepatopancreas"?


The effects of hibernation on the chemical composition of cerebrospinal and intraocular fluids, blood plasma and brain tissue of the woodchuck (Marmota monax).


Seasonal variations and the effects of nesting and moulting on liver mineral content in the mouse sparrow (Passer domesticus L.).


Intestinal absorption of D-glucose and D-galactose in rats infected with Nematospiroides dubius.


Effects of hypophysectomy on osmoregulation in the euryhaline flounder, Platichthys flesdus (L.), in sea water and in fresh water.


The effects of restricting gaseous exchange across the eggshell on the pO2, pCO2 and pH values of the extraembryonic fluids of the chick embryo.


Conductive heat loss to sand in California sea lions and a harbor seal.


The effects of artificial radiation on energetics of the eastern chipmunk, Tamias striatus.


O2 consumption and K+-Na+ balance of elasmobranch kidney slices after replacement of urea by thiourea or acetamide.


Biliary excretion of insulin in the adult chicken.


Biochemical responses elicited in normal or prolactin-treated Xenopus laevis (Daudin) specimens by environmental changes.


Effects of salmon gonadotropin on ovulation in the ayu, Plecoglossus altivelis, with special reference to water balance.


FSH content of the anterior pituitary and the incorporation of L-lysine-U-14C into testicular proteins of heat-acclimatized rats.


The size and shape of erythrocytes in the herring Clupea harengus L.


The adrenal cortex and water conservation in desert rodents.


Antidiuretic hormone and water conservation in desert rodents.


Normal electrocardiogram of the chicken: its variations during vagal stimulation and following vagotomies.


Field studies of hearing in two species of flatfish Pleuronectes platessa (L.) and limanda limanda (L.) (family pleuronectidae).


Letter: Recordings of saccular microphonic potentials in the perch.


Letter: Active sodium transport: a source of metabolic heat during cold adaptation in mammals.


Seasonal effects of dehydration in air on urea production in the frog Rana pipiens.


Behavioral regulation of internal temperature in the brown bullhead, Ictalurus nebulosus.


Natural daily temperature acclimation of eastern red efts, Notophthalmus v. viridescens (Rafinesque) (Amphibia: Caudata).


Correlation of tissue water content with lymphatic structure in toad and turtle bladders.


Input characteristics of the intrinsic cells of the optic tectum of teleost fish.


Comparison of endocrine function in normal and genetically athymic mice.


Modification of 1-tyrosine-induced keratopathy by adrenal corticosteroids.


Pseudoisozymes of hepatic tyrosine aminotransferase.


Ampicillin compared with penicillin and chloramphenicol combined in the treatment of bacterial meningitis.


Zollinger-Ellison syndrome. Clinical features and long-term follow-up.


Regional variation in capillary permeability of ventricular myocardium.


Effect of prolonged isolation on learning, biogenic amine turnover and aggressive behaviour in three strains of mice.


Tarsal tunnel syndrome.

Tarsal tunnel syndrome.


Cardiovascular function in the mammalian foetus.


Mosquito light trap surveys in Korea 1969-1971.


Laboratory models in filariasis: a review of filarial life-cycle patterns.


Effects of ready-to-eat breakfast cereals on dental caries experience in adolescent children: a three-year study.


Fatal pneumonia presenting as transient neonatal tachypnea.


The effect of dopamine and noradrenaline antagonists on amphetamine induced locomotor activity in mice and rats.


Allosteric modulation of the transient kinetics of carboxytryptophan oxygenase complex formation after laser flash photolysis.


Crotonyl coenzyme A reductase activity of bovine mammary fatty acid synthetase.


Regulation of glutamine synthetase from Bacillus subtilis by divalent cations, feedback inhibitors, and L-glutamine.


Anesthetic-induced malignant hyperpyrexia in children.


Visit to Mexico, 1973.

Visit to Mexico, 1973.


Editorial: Progress and problems in emergency medical care.


The cerci and abdominal giant fibres of the house cricket, Acheta domesticus. II. Regeneration and effects of chronic deprivation.


Changes in microbody-marker enzymes during growth of Tetrahymena pyriformis E.


The determinants of growth and form.

The determinants of growth and form.


Thermochemical studies of human red blood cells: enthalpy changes on dilution in buffers.


The cerci and abdominal giant fibres of the house cricket, Acheta domesticus. I. Anatomy and physiology of normal adults.


Address of the president Sir Alan Hodgkin, O.M. at the Anniversary Meeting, 30 November 1973 (Thomas Young).


The founding of the Scandinavian Rheumatological Society and the early history of the European League Against Rheumatism.


In vitro on an HCG responsive, testosterone secreting adrenal cortical adenoma.


Review of the original chemical research into psychotropic agents in Czechoslovakia.


A new enzymic assay for human deficiencies of coenzyme Q10.


Effects of leucine and isoleucine on nicotinamide nucleotides of erythrocytes.


The ecology of Whataroa virus, an alphavirus, in South Westland, New Zealand. The findings of a survey on the ecology of an alphavirus over the years 1964-9 are reviewed. Evidence is presented to show that wild birds constitute a vertebrate reservoir of the virus and that mosquitoes, primarily Culiseta tonnoiri and Culex pervigilans, which are both endemic New Zealand species, are responsible for summer transmission.Serological evidence of infection was obtained in all years and evidence is presented to indicate that the virus is enzootic rather than being reintroduced each spring. The number of birds with antibody increased before mosquitoes became active in the spring and possible explanations of this are discussed.The mean temperature in the hottest month in the study area is substantially below that in other areas with enzootic mosquito-borne viruses and experimental studies showed that Whataroa virus was able to replicate more rapidly in mosquitoes at low temperatures than any arboviruses previously studied.The main natural focus of infection appeared to be in a modified habitat and the introduced song thrush (Turdus philomelos) to be the main vertebrate reservoir host.


The cariostatic effectiveness of a phosphate-fluoride gel administered annually to school children; final results.


Studies on the microbial flora in the air of submarines and the nasopharyngeal flora of the crew. Airborne bacteria surveys in nuclear submarines show that the total microbial load was maintained at satisfactorily low levels during prolonged patrols despite factors which were expected to increase this form of pollution.The isolation rates of Staphylococcus aureus and Neisseria meningitidis from nasal and nasopharyngeal swabs respectively, together with the serum antibody titres to Mycoplasma pneumoniae, before and after patrols suggested that the transmission of these organisms between individuals was not much increased by patrol conditions. The finding of higher numbers of airborne gram-negative rods and bodily contamination by enterobacteria is frequently reported in submersibles but does not appear to cause major outbreaks of illness in nuclear submarine crews.


Two-year evaluation of a self-administered procedure for the topical application of acidulated phosphate-fluoride; final report.


Carnitine and glycerylphosphorylcholine in the reproductive tract of the male rat.


Clinical experiences in the management of cold injuries: a study of 110 cases.


Mucosal biopsy in ulcerative colitis for evaluating topical hydrocortisone therapy.


Latest advances in diagnostic urologic radiology. I. Magnification renal arteriography.


Urogenital anomalies and congenital rubella syndrome.


Clinical evaluation of an oral combined antihistaminic sympathomimetic preparation.


A controlled clinical comparison of Lunerin and Rinomar in allergic rhinitis.


Serological investigations as applied for epidemiological evaluation of the population at a given area.


Effects of morphine, in vitro and in vivo, on thyrosine hydroxylase activity in rat brain.


Effects of chronic treatment with histamine on catecholamine content and synthesis in rat brain, heart and adrenals.


Biochemical studies on the effect of papaverine on polymorphonuclear leucocytes.


Talc embolism: sudden death following intravenous injection of phenyltoloxamine.


Medicine accepts another challenge.

Medicine accepts another challenge.


Foreign trained physicians in Illinois.

Foreign trained physicians in Illinois.


Headache associated with low spinal fluid pressure syndrome. (Primary intracranial hypotension).


The treatment of accessible malignant tumors by irradiation.


Allergic aspergillosis in a family.

Allergic aspergillosis in a family.


Surgical grand rounds: Radiation enteritis.


Prevention of accidental falls in infancy by counseling mothers.


Visceral larva migrans.

Visceral larva migrans.


Measles in suburban Cook County.

Measles in suburban Cook County.


View box: bezoars occurring in a gastric remnant after a gastrectomy.


Diagnostic patterns in disability in Illinois and the nation.


EKG of the month. Bundle-branch block.

EKG of the month. Bundle-branch block.


Guest Editorial: The peril of "non-peer peer review".


Rift Valley fever. 3. Viraemia in cattle and sheep. 4. The susceptibility of mice and hamsters in relation to transmission of virus by mosquitoes.


An exploratory psychological study of digestive diseases.


Side effects of antihypertensive drugs.

Side effects of antihypertensive drugs.


A possible proprioceptor in Ceriantheopsis americanus (Cnidaria, Ceriantharia).


The effect of acute hypoxia on cardiac dysrhythmias induced by mesencephalic stimulation.


Diseases of the skin. Drug ill effects on the skin.


Response of leucocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic bronchial asthma. The finding by several workers that biochemical responses to catecholamines are diminished in asthmatic patients during periods of active asthma as compared to normal subjects has led to the recognition of the beta-adrenergic blockade phenomenon, a common accompaniment of extrinsic bronchial asthma. Using an intact cell method to measure leucocyte adenyl cyclase activity, we have been able to show that there is a noticeably reduced responsiveness of this enzyme system (which is now identified with beta-receptor function) to isoprenaline in the leucocytes of patients suffering from acute bronchial asthma, but that asthmatic patients in remission could not be distinguished from normal persons in this respect. Evidently the defective beta-receptor function may be associated with overactivity of the alpha-receptors in acute bronchial asthma, since the responsiveness to isoprenaline stimulation could be restored towards normal by concomitant treatment of the leucocytes of these patients with alpha-receptor blocking drugs such as phentolamine or thymoxamine. Ouabain, though somewhat less potent, also enhanced responsiveness to isoprenaline stimulation. The relation of these results to the clinical observation of adrenaline resistance in active asthma suggests that alpha-receptor blocking drugs may be of value in restoring the sensitivity of beta-receptors to sympathomimetic amines.


Chemical modification of the crayfish neuromuscular junction.


Effects of beta-adrenergic blockade and stimulation on normal human airways.


Effect of experimental cryptorchism on testis L-iditol: NAD oxidoreductase (sorbitol dehydrogenase or ketose-reductase).


Gamma-glutamyl transpeptidase in cancer diagnosis.


Hydrogen transfer from NADPH to steroid by testicular 20 alpha-hydroxysteroid dehydrogenase: stereospecficity and isotope effect.


On the specificity of alpha adrenergic receptor labeling by 14C-dibenamine.


The mechanism of action of histamine on the isolated rat uterus.


Beta adrenergic blockade on intramyocardial distribution of coronary blood flow.


A rhynchosaur from the Upper Triassic Maleri Formation of India.


Equipment for clinical chemistry and its evaluation.


Automated clinical chemistry and haematology in a hospital region.


Computers and the organization of medical care. What computers can and cannot do.


Advanced technology in the hospital laboratory: handling and interpreting multiple results.


The Stockholm County Council's medical information system.


Allied health manpower strategies: estimates of the potential gains from efficient task delegation.


Computer-based records in the clinic (a).


Computer-based records in the clinic (b).


Psychological prediction of leadership in nursing.


Linked record medical information systems.


The computing approach to clinical diagnosis.


Surgical diagnosis assisted by a computer.


Pattern recognition by computer.

Pattern recognition by computer.


A discussion on the value of automation in the health service. Advanced technology--research and the future.


Automated e.c.g. interpretation in the National Health Service.


Biometric findings on cardiac neurosis. II. ECG and circulation findings of cardiophobic patients during standardized examination of the circulatory system.


Biometric findings on cardiac neurosis. I. Character and clinical aspects of cardiac neurosis.


The pressor effect of oxotremorine and arecoline in rats.


On the decarboxylation of alpha-keto acids by isolated chloroplasts.


Energy conservation in membranes of mutants of Escherichia coli defective in oxidative phosphorylation.


Metabolites of p-aminobenzoic acid. V. Isolation and properties of p-aminobenzyl alcohol dehydrogenase.


Kinetic aspects of nitrate reductase from Cyanidium caldarium. Inhibition by reduced pyridine nucleotides.


Kinetic analysis of partially purified glucose-6-phosphate dehydrogenases from rat muscle, adipose tissue and liver, and from baker's yeast.


Nonspecific activity and habituation of tonic and phasic skin conductance in somatic complainers and controls as a function of auditory stimulus intensity.


Measurements of serum L-alanine aminotransferase activity on the centrifichem and on the LKB 8600.


Antagonism of histamine H2-receptors and gastric secretion.


Orchidopexy using a Dartos pouch.

Orchidopexy using a Dartos pouch.


Hepatic metabolic pattern in experimental nephrotic syndrome: glycolysis, gluconeogenesis, and amino acid metabolism.


Beta-adrenergic blocking drugs in anaesthesia.


Nicotinamide coenzymes in heart and coronary blood during myocardial infarction.


Effeminate behavior in boys. Parental age and other factors.


An observation about the relative hardiness of bacterial spores and planetary quarantine.


Histochemical study of gamma glutamyl transpeptidase (GGT) in experimental intrahepatic and extrahepatic cholestasis.


Mechanism of electron transport and energy conservation in the site I region of the respiratory chain.


Complications during physical rehabilitation of coronary patients, with comments on drug therapy.


Characteristics of the catecholamine and histamine receptor sites mediating accumulation of cyclic adenosine 3',5'-monophosphate in guinea pig brain.


Maternal and neonatal metabolism of analgesic drugs.


Amino acids as central nervous transmitters: the influence of ions, amino acid analogues, and ontogeny on transport systems for L-glutamic and L-aspartic acids and glycine into central nervous synaptosomes of the rat.


Federation of Prosthodontic Organizations: Annual Session Report, 1973.


Editorial: Sports medicine in modern times. A short historical survey.


Some factors affecting the uptake, binding and retention of (3H)cortisol by the chick embryo retina as related to enzyme induction.


Studies on the role of adenosine 3',5'-monophosphate during glucose repression in rat liver.


Thyroxine deiodination associated with NADPH-dependent (enzymatic) and Fe3+-ADP-catalyzed (nonenzymatic) reactions in hepatic microsomes.


Human neuroblastoma cell culture: effect of 5-bromodeoxyuridine on morphological differentiation and levels of neural enzymes.


The genesis of the initial blood pressure peak following IV administration of certain catecholamines.


The cardiovascular activity of 2-amino-5-(3,4-dichlorophenoxymethyl)-2-oxazoline (APMO).


Chromosomal abnormalities in undescended testes.


President's opening speech.

President's opening speech.


Homogeneous antibodies: a probe for the problem of antibody diversity.


Isoproterenol blockade in man; comparison between penbutalol and acebutolol.


The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficient Drosophila melanogaster.


Effect of adenosine and some of its analogs on renal hemodyamics.


Treatment of exotic parasitic diseases.

Treatment of exotic parasitic diseases.


Plasma corticosteroid levels in anaphylactic shock of guinea pigs.


Ultrastructure of lymphoid cells involved in local graft-versus-host reaction.


An electron microscope study of the delayed effects on rabbit spermateleosis following experimental cryptorchidism for twenty-four hours.


International Council of Nurses 15th Quadrennial Congress; Mexico 73.


A light microscope study of the immediate and delayed effects on rabbit spermatogenesis following experimental cryptorchidism for twenty-four hours.


Testicular tumors. A retrospective study.


[Correlations between the results of pharmacokinetic and pharmacological studies on several pipotiazine esters].


Purification and properties of L-erythro-3,5-diaminohexanoate dehydrogenase from Clostridium sticklandii.


Fluorescence and optical characteristics of reduced flavines and flavoproteins.


Allogeneic marrow grafting for treatment of aplastic anemia.


G-6-PD Manchester: a new variant associated with chronic nonspherocytic hemolytic anemia.


Glucocorticoid and mineralocorticoid effects in rat liver and kidney.


Action of fully co-ordinated 1,10-phenanthroline transition metal chelates on the guinea-pig isolated atrium.


A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states.


Heart rate after combined vagal and sympathetic blockade with atropine and different beta-receptor blocking agents.


The correlation between bacteriological findings in the nose and maxillary sinus in acute maxillary sinusitis.


Graft-versus-host disease after intrauterine and exchange transfusions for hemolytic disease of the newborn.


Letter: Undescended testes.

Letter: Undescended testes.


Editorial: Trojan-horse lymphocytes.

Editorial: Trojan-horse lymphocytes.


Kinetics of atropine and Diamox inhibition of histamine-stimulated gastric secretion.


The use of allogeneic freeze-dried skin grafts in the oral environment. A clinical and histologic evaluation.


The ecology of streptococcus mutans in carious lesions and on caries-free surfaces of the same tooth.


The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol. Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.


The separation and enzymatic characterization of inner and outer membranes of rat-heart mitochondria.


Influence of fatty acid and sterol composition on the lipid phase transition and activity of membrane-bound enzymes in Acholeplasma laidlawii.


Metabolic alterations in the axotomized superior cervical ganglion of the rat. I. Energy metabolism.


Metabolic alterations in the axotomized superior cervical ganglion of the rat. II. The pentose phosphate pathway.


Treatment of acute exacerbations of chronic bronchitis with clindamycin.


Diurnal variation in the symptoms of hay fever: implications for pharmaceutical development.


The use of mutants of Escherichia coli K12 in studying electron transport and oxidative phosphorylation.


Characteristic serum glycoproteid curves in syngeneic and semiallogeneic skin transplantation in rats.


The pattern of dental diseases in the Asian Area of the Pacific Basin.


The pattern of dental disease in the South Pacific Area of the Pacific Basin.


The prevention of dental caries by mouthrinsing with solutions of neutral sodium fluoride.


Morphogenetic properties of the parts of the colony of Clytia johnstoni.


Construction techniques for wrought-wire retentive clasp arms as related to clasp flexibility.


Base composition of ribosomal RNA and evolution.


The castration of horses: or castration of half a horse?


Comparative susceptibility of eight mosquito species to Sindbis virus.


The diagnostic value of gamma-GT-estimations on blood samples collected in conjunction with exsanguination of cattle.


Anesthetic uptake--of mice and men (and whales).


Facial injuries in football.

Facial injuries in football.


Oscillations of enzyme activities during the cell-cycle of a glucose-repressed fission-yeast Schizosaccharomyces pombe 972h-. 1. Increased specific activities of cytochrome c oxidase, catalase, succinate dehydrogenase, succinate-cytochrome c oxidoreductase, NADH-cytochrome c oxidoreductase and malate dehydrogenase were observed during glucose de-repression of Schizosaccharomyces pombe. 2. The cell-cycle of this organism was analysed by three different methods: (a) harvesting of cells at intervals from a synchronous culture, (b) separation of cells by rate-zonal centrifugation into different size classes and (c) separation of cells by isopycnic-zonal centrifugation into different density classes. 3. Measurement of enzyme activities during the cell-cycle showed that all the enzymes assayed [cytochrome c oxidase, catalase, acid p-nitrophenylphosphatase, NADH-dehydrogenase, NADH-cytochrome c oxidoreductase, NADPH-cytochrome c oxidoreductase, succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase (NADP) and fumarate hydratase] show periodic expression as ;peaks'. 4. Cytochrome c oxidase shows a single maximum at 0.67 of a cycle, whereas succinate dehydrogenase exhibits two maxima separated by 0.5 of a cell-cycle. 5. All other enzymes assayed showed two distinct maxima per cell-cycle; for catalase, malate dehydrogenase and NADPH-cytochrome c oxidoreductase there is the possibility of multiple fluctuations. 6. The single maximum of cytochrome c oxidase appears at a similar time in the cycle to one maximum of each of the other enzymes studied, except for NADH dehydrogenase. 7. These results are discussed with reference to previous observations on the expression of enzyme activities during the cell-cycle of yeasts.


Effect of vitamin A deficiency on protein catabolism in chicks.


Respiration-driven proton translocation in Escherichia coli. Measurements were made of the stoicheiometry of respiration-driven proton translocation coupled to the oxidation of NAD(P)-linked or flavin-linked substrates in intact cells of Escherichia coli. Observed stoicheiometries (-->H(+)/O quotient; Mitchell, 1966) were approx. 4 with l-malate as substrate and approx. 2 for succinate, d-lactate and glycerol oxidation. It is concluded that the potential number of equivalent energy-conservation sites associated with the respiratory chain is 2 in aerobically grown cells of E. coli harvested during the exponential phase of growth.


The inhibition of mitochondrial respiration by inhalational anaesthetic agents.


Androgen metabolism in rat testicular tissue.


Effects of gonadotropins on cyclic AMP production by isolated seminiferous tubule and interstitial cell preparations.


Biosynthesis of wax esters in cell-free preparations of Euchaeta norvegica.


The degradation of CoA: subcellular localization and kinetic properties of CoA- and dephospho-CoA pyrophosphatase.


Microsomal drug-metabolizing enzyme activity in livers of bats.


Some properties of NADPH-cytochrome c reductase reconstitutively active in fatty-acid omega-hydroxylation.


The rôle of cytochrome P-450 in cholesterol biosynthesis.


D-galactose dehydrogenase from Pseudomonas saccharophila. Purification, properties and structure.


Reduction of the acetyl coenzyme A carboxylase content of Saccharomyces cerevisiae by exogenous fatty acids.


Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange.


Does levodopa alter depression and psychopathology in Parkinsonism patients? Twenty-seven Parkinsonism patients and 31 controls, matched for age and verbal IQ, were tested on an objectively scored personality test (Minnesota Multiphasic Personality Inventory) at the beginning of the patients' levodopa therapy and three months later. Patients, but not the controls, were retested after 15 months of levodopa treatment. The patients, all of whom were intact intellectually, obtained MMPI scores indicating moderate depression before beginning levodopa treatment. There was no test evidence to indicate that levodopa significantly increased or decreased the amount of depression in the patients after three or 15 months of levodopa. The patient group, however, significantly increased their Index of Psychopathology (Ip) score after 15 months of levodopa but not after three months.


The action of Bothrops neuwiedii phospholipase A2 on mitochondrial phospholipids and electron transfer.


Neurotransmitter synthetic enzymes.

Neurotransmitter synthetic enzymes.


The fate of dieldrin in a model ecosystem.


Stress, adrenocortical activity and sleep habits.


Therapy of infections with parenteral cephalexin.


Immunochemical analysis of rabbit antibodies against vasopressin.


Role of some biogenic substances in migraine and relevant mechanism in antimigraine action of ergotamine--studies in an experimental model for migraine.


Desaturation and saturation of fatty acids by sheep rumen bacteria: optimal conditions and cofactor requirements.


The allergic reaction. Application of the new immunology.


Feeding elicited by alpha and beta adrenoceptor agonists injected intrahypothalamically in sheep.


Selective adrenergic stimulant actions of 1-isopropylamino-3-(2-thiazoloxy)-2-propanol (ITP) in anesthetized cats.


Hormonal mechanisms in regulation of gene expression.


Inhibition of catecholamine synthesis during ontogenic development.


Neurotransmitter synthesis in the tectum of the tiger salamander Ambystoma tigrinum.


Hemopoietic cell line-specific effects of renal granulopoietic factor (GPF) on transplantable mouse marrow stem cells: comparison with erythrocyte stimulating factor (ESF) and endotoxin.


Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice.


Self-application of fluoride by rinsing.


Propranolol and serum gastrin in postvagotomy insulin tests.


Weekly mouth-rinsing with 3000 ppm of fluoride; the effect of concentration of fluoride in the enamel.


Editorial: The patient needs.

Editorial: The patient needs.


On the graft-versus-host nature of the allogeneic effect in a tumor isograft system.


Mechanisms of immunosuppression by antilymphocyte antibody.


Autoradiographic studies on small lymphocytes in rats affected by graft-versus-host reaction.


Radiobiology as the basis of radiotherapy.


A histochemical study of the avian liver.


Kidney preservation in a hypothermic "cytoplasmic" solution before transplantation.


Initial clinical experience with I.C.I. 66.082, a new beta-adrenergic blocking agent, in hypertension.


The William B. Sherman Memorial Address in memory of Dr. W. B. Sherman.


Controlled interviews using drugs. II. Comparisons between restricted and freer conditions.


Attempted induction of interferon by bacterial vaccines in allergic and nonallergic humans.


Theophylline and chlorpheniramine in childhood asthma. Dose requirements for children 6 to 12 years (therapeutic orphans) and young adults 13 to 18 years of age receiving cromolyn sodium prophylaxis.


A psychosocial description of penitentiary inmates.


Postrelease adjustment of day and full-time psychiatric patients.


Presence of the complete sorbitol pathway in the human normal umbilical cord tissue.


Effects of alprenolol on central hemodynamics and exercise tolerance in patients with angina pectoris.


Striato-pallidonigral degeneration. (A diagnostic dilemma--case report).


Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets.


Pathogenesis of autoimmunity in New Zealand mice. V. Loss of thymic suppressor function.


Plasmodium berghei: mechanisms and sites of resistance to sporogonic development in different mosquitoes.


Physicians' assistants update--fall 1973.


Circadian rhythms during drug-induced coma. (Transverse study of rectal temperature, heart rate, systolic blood pressure, urinary water and potassium).


Letter: Cavitary pneumonia in a 76-year-old woman.


Spontaneous epizootic of pneumococcus infection in guinea-pigs.


A calcium ionophore simulating the action of epinephrine on the alpha-adrenergic receptor. Calcium acting through the ionophore A-23187 caused massive K(+) release from rat parotid slices. The ionophore thus simulates the action of epinephrine on the alpha-adrenergic receptor in this system. The alpha-adrenergic and cholinergic receptors are, however, not involved in the action of the ionophore since phetolamine and atropine had no effect on the ionophore-induced K(+) release. Amylase secretion, which is induced by epinephrine through the beta-adrenergic receptor but does not require Ca(++) in the medium, was only slightly increased by the ionophore in the presence of Ca(++). The K(+) released by Ca(++) through the ionophore was regained by the cells upon chelation of Ca(++) with ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid. Similar to the action of epinephrine on the alpha-adrenergic receptor, the K(+) release induced by the ionophore is specific for Ca(++), which cannot be substituted by 2.5 mM Sr(++), Mg(++), or Ba(++). The results suggest that epinephrine, like the ionophore, introduces Ca(++) into the cell to mediate K(+) release. It is proposed that the ionophore A-23187 may be an effective probe to test whether other Ca(++)-requiring hormones and neurotransmitters act in a similar fashion to produce their diverse physiological responses.


Nonphagocytic release of neutral protease and beta-glucuronidase from human neutrophils. Regulation by autonomic neurohormones and cyclic nucleotides.


Activation of transcription of hut DNA by glutamine synthetase. The correct transcription of the hut (histidine utilization) operon DNA of Salmonella typhimurium requires activation either by 3':5'-cyclic adenosine monophosphate and catabolite-activating protein or by nonadenylylated glutamine synthetase (EC 6.3.1.2.). Thus, glutamine synthetase plays a regulatory role distinct from its enzymatic function.


New health professionals in pediatrics.

New health professionals in pediatrics.


Identification and partial characterization of inositol: NAD+ epimerase and inosose: NAD(P)H reductase from the fat body of the American cockroach, Periplaneta americana L.


On the effect of temperature on the absorption spectra of free and protein-bound flavines.


Differences in distribution pattern of marker enzymes among subcellular fractions from Morris hepatoma 16.


Isolation and characterization of a phosphonic acid rich glycoprotein preparation from Metridium dianthus.


Hypertensive pulmonary vascular disease complicating congenital heart disease. A review.


The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Intra and intersubunit interactions between the catalytic regions of the bifunctional enzyme.


Effects of phenobarbital administration on rates of ethanol clearance and on ethanol-oxidizing enzymes in man.


Blood pressure elevation in pregnancy.

Blood pressure elevation in pregnancy.


Letter: Salicylazosulfapyridine in clinical practice.


Mapping of the pneumococcus chromosome. Linkage between the genes conferring resistances to erythromycin and tetracycline and its implication to the replication of the chromosome.


Intrarenal effects of phenoxybenzamine on sodium reabsorption.


Segmental response of the macrophage plasma membrane to a phagocytic stimulus. A method of attaching mouse RBCs to mouse macrophages is described. Both cell types were coated with rabbit anti-mouse macrophage F(ab')(2), and cross-linkage of cells was effected with sheep F(ab')(2) directed against rabbit F(ab')(2). 98% of macrophages attached an average of 11 RBCs each. Attachment occurred at 37 degrees C and was stable for at least 4 h. Less than 0.1% of macrophages ingested RBCs under these conditions. Latex particles and opsonized pneumococci were ingested as avidly by RBC-coated macrophages as by native macrophages. Ingestion of these particles did not prompt ingestion of attached RBCs. When anti-RBC IgG was added, however, over 90% of macrophages ingested an average of six RBCs each. Thus, ingestion of one particle does not trigger generalized phagocytosis of all particles attached to the cell's plasma membrane, and the phagocytic stimulus is confined to the segment of the cell's plasma membrane immediately adjacent to the particle being ingested.


Discrimination between mathematical models of biological systems exemplified by enzyme steady state kinetics.


Enzyme histochemistry of the liver in extrahepatic biliary obstruction. A comparison between man, dog and rat.


Cardiovascular effects of tolamolol (UK-6558), a new beta-adrenoreceptor blocking drug, in pinealectomized hypertensive rats.


Effect of chronic ethanol treatment on tryptophan oxygenase, tyrosine aminotransferase and general protein metabolism in the intact and perfused rat liver.


Aggregation of blood platelets by biogenic amines and its inhibition by antiadrenergic and antiserotoninergic agents.


Effect of 16alpha-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes.


Triphosphopyridine nucleotide specific isocitrate dehydrogenase from Azotobacter vinelandii. Alkylation of a specific methionine residue and amino acid sequence of the peptide containing this residue.


Dental epidemiological surveys of Sarawak school children.


A periodontal programme for a developing country (Western Samoa).


Recovery from intravenous sedation, secobarbital and propiomazine.


Regulation of corticosteroid hydroxylations: the intramitochondrial dielectric constant and proteolipids of adrenodoxin and cytochrome P450.


Newer aspects of substrate binding to cytochrome P-450.


The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations.


DPNH synergism of TPNH-dependent mixed function oxidase reactions.


Pseudomonas putida cytochrome P-450: ligands of the substrate-free and substrate-bound states of the ferric hemoprotein.


Role of phospholipid in the reconstituted liver microsomal mixed function oxidase system containing cytochrome P-450 and NADPH-cytochrome P-450 reductase.


Determination of active centers of hepatic microsomal cytochrome P-450 by metyrapone, applying mutual depletion system kinetics.


Mechanisms of inhibition of drug metabolic reactions.


Metyrapone and other modifiers of microsomal drug metabolism.


Structural aspects of the active site of cytochrome P-450cam.


Formation and binding of carbanions by cytochrome P-450 of liver microsomes.


Effects of inhibitors on drug metabolism.


Chemistry of cytochrome P-450 purified from endocrine systems.


Enhancement of type II substrate oxidation and of azo reduction in the isolated rat liver and in vitro by metyrapone.


Synthesis and degradation of microsomal hemoproteins.


Genetic differences in cytochrome P-450 during induction of mono-oxygenase activities.


Induction of the unspecific microsomal hydroxylase in the human liver.


Effect of steroids on drug metabolism in male and female rats.


The regulation of heme synthesis related to drug metabolism.


The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450.


Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.


Heme and hemoprotein catabolism during stimulation of microsomal lipid peroxidation.


Drug-induced destruction of cytochrome P-450.


Characterization of partially purified cytochromes P-450 and P-448 from rat liver microsomes.


Initiation factor activity in liver after 3-methylcholanthrene administration.


The effect of phenobarbital on the turnover of messenger RNA's for microsomal enzymes.


Oxidation of an amino carbinol by an NAD+-dependent microsomal dehydrogenase.


The role of cytochrome P-450 in the N-oxidation of individual amines.


Microsomal flavoprotein-catalyzed N-oxidation of arylamines.


Phenylacetone oxime--an intermediate in amphetamine deamination.


The mechanism of microsomal deamination: heavy isotope studies.


The role of cytochrome P-450 of placenta in facilitated oxygen diffusion.


Effect of synergists on drug metabolism.


Differences in P-420 hemoproteins from untreated and 3-methylcholanthrene-treated rats.


The cytochrome P-450-containing mono-oxygenase system of rat kidney cortex microsomes.


The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism.


Some selected studies on hepatic microsomal drug-metabolizing enzymes--environment interactions.


A specific carrier for oxygen and carbon monoxide in the lung and placenta.


Characterization of lung microsomes as related to drug metabolism.


Interindividual differences in rates of drug oxidation in man.


Ethanol metabolism: oxidative and peroxidative mechanisms.


Induction of aryl hydrocarbon hydroxylase in human skin.


The significance and characterization of hepatic microsomal ethanol oxidation in the liver.


Optical and magnetic probes of the structure of cytochrome P-450's.


Interindividual differences in drug oxidation: clinical importance.


The role of hydrogen peroxide and catalase in hepatic microsomal ethanol oxidation.


Cytochrome P-450 associated with free hepatic polyribosomes.


Drug metabolism as a cause of drug toxicity.


Partial purification and some spectral properties of hepatic microsomal cytochrome P-450.


Effects of phenobarbital treatment on biliary excretion in man.


Studies on the metabolic effect induced in the rat by a high-fat diet. Estimation of glucose-carbon utilization through various metabolic pathways in epididymal-adipose tissue.


Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver.


Inhibition of enzymes which interact with citrate by (--)hydroxycitrate and 1,2,3,-tricarboxybenzene.


Tetrahydrocannabinol metabolism in man.

Tetrahydrocannabinol metabolism in man.


Dynamic organization of endoplasmic reticulum membranes.


The synthesis and degradation of membrane proteins.


On the mechanism of hydroxylation reactions catalyzed by cytochrome P-450.


Kinetics and inelastic light-scattering studies of the role of phospholipids in the microsomal membrane structure.


Periodontal disease condition and oral hygiene status of public school children, city of Manila.


Characterization of solubilized cytochrome P-450.


Turnover of enzyme proteins in microsomal membrane.


Suppression of DNA synthesis in hepatoma cells exposed to glucocorticoid hormone in vitro. Glucocorticoid hormone is shown to markedly suppress DNA synthesis in a line of rat hepatoma cells in vitro. In the presence of 300 nM hydrocortisone or 30 nM dexamethasone the incorporation of radioactive thymidine falls to 50% of control levels by 36 hr, and at higher concentrations of hormone inhibition can be noted as early as 12 hr and is nearly complete by 24 hr. This inhibition of radioactive thymidine incorporation reflects a true suppression of DNA synthesis, is accompanied by a corresponding inhibition of cell proliferation, and is readily reversible upon subsequent removal of hormone. In contrast to previously described effects of the glucocorticoid hormones on various cells of lymphoid origin, the inhibition of DNA synthesis in these hepatoma cells is not accompanied by appreciable cell lysis or by degradation of preformed DNA, and even when [(3)H]thymidine incorporation into DNA is inhibited by 90% or more, incorporation of [(14)C]uridine into RNA proceeds with little change. These findings all parallel previous observations on the effects of glucocorticoid hormone on the livers of intact animals and suggest that studies on the mechanism of the inhibition of DNA synthesis in the present more isolated system may lead to a better understanding of the means by which these compounds inhibit liver growth in vivo. Despite the ready suppressibility of DNA synthesis in these hepatoma cells and in two other cell lines of liver origin, none of these cell lines was found to be inducible for tyrosine aminotransferase. The apparent dissociation between two "steroid-sensitive" phenomena is of interest and warrants further investigation.


Histochemical fiber composition of some facial muscles in the cat in relation to their contraction properties.


Excerpts from the casebook of Jason Harbro, M.D., AME.


Studies on the molecular function of cytochrome P-450 during drug metabolism.


Metabolic stability of 2, 3, 7, 8-tetrachlorodibenzo-P-dioxin in mammalian liver microsomal systems and in living mice.


Biosynthesis and degradation of saccharopine, an intermediate of lysine metabolism. Lysine-2-oxoglutarate reductase was prepared from ox liver and its characteristics were examined. Its activity was totally inhibited in the presence of NH(4)Cl. Under conditions that inhibit saccharopine formation, and in the presence of NADP(+), ox liver mitochondria were found to catalyse the hydrolysis of saccharopine to lysine and alpha-oxoglutarate. The enzyme involved was named saccharopine oxidoreductase. It was partially purified and separated from lysine-oxoglutarate reductase. Comparison of the properties of these two enzymes showed that saccharopine degradation was stimulated under conditions that inhibit its formation. The effect of pH, various cofactors and stability during incubation confirm that saccharopine biosynthesis from, and degradation to, lysine are catalysed by two distinct enzymes.


The effect of magnesium ions on the dimethylaniline oxidation rate and electron transfer in liver microsomal fraction. 1. Reactions of N-demethylation, p-hydroxylation and N-oxidation of one substrate, i.e. dimethylaniline, have been used to show that the activating effect of Mg(2+) takes place only in the first two reactions. 2. An increase in V(max.) of N-demethylation of dimethylaniline is accompanied by an increase in K(m). In the p-hydroxylation of dimethylaniline V(max.) increases whereas K(m) does not change. A comparison of the changes in the K(m) values of these reactions with the change in K(s) shows that in both cases K(m) does not characterize the affinity of cytochrome P-450 for dimethylaniline. 3. The rate-limiting site of N-demethylation and p-hydroxylation of dimethylaniline, as well as the total rate of NADPH oxidation in the presence of dimethylaniline, is between cytochromes b(5) and P-450. Addition of Mg(2+) to the incubation medium changes the hydrophobic environment of phosphatidylcholine in the membrane, the process being accompanied by a sharp increase in the fluorescence quantum yield of 8-anilinonaphthalene-1-sulphonate.


The tritium isotope effect of sn-glycerol 3-phosphate oxidase and the effects of clofenapate and N-(2-benzoyloxyethyl)norfenfluramine on the esterification of glycerol phosphate and dihydroxyacetone phosphate by rat liver mitochondria. 1. Owing to a (3)H isotope effect, the mitochondrial sn-glycerol 3-phosphate oxidase (EC 1.1.99.5) had a mean activity which was 8.4 times less with sn-[2-(3)H]-rather than with sn-[1-(14)C]glycerol 3-phosphate as a substrate. 2. A method for measuring the simultaneous synthesis of lipid from glycerol phosphate and dihydroxyacetone phosphate in rat liver mitochondria is described. 3. The lipid synthesized by rat liver mitochondria from sn-[1-(14)C]glycerol 3-phosphate was mainly phosphatidate and lysophosphatidate, whereas that synthesized from dihydroxy[1-(14)C]acetone phosphate was mainly acyldihydroxyacetone phosphate. 4. Additions of NADPH facilitated the conversion of acyldihydroxyacetone phosphate into lysophosphatidate and phosphatidate. 5. Hydrazine (1.4mm) or KCN (1.4mm) inhibited the synthesis of lipids from dihydroxyacetone phosphate but not from glycerol phosphate. 6. Clofenapate (1-2.5mm) inhibited the synthesis of lipids from dihydroxyacetone phosphate but slightly stimulated synthesis from glycerol phosphate. 7. The methanesulphonate of N-(2-benzoyloxyethyl)norfenfluramine, at 0.25-0.75mm, inhibited lipid synthesis from both glycerol phosphate and dihydroxyacetone phosphate.


N-methylation, a newly identified pathway in the dog for the metabolism of oxprenolol, a beta-receptor blocking agent.


Membrane-bound gamma-glutamyl transpeptidase and its rôle in phenylalanine absorption-reabsorption in the larva of Musca domestica.


Biotransformation of 2-hydroxynicotinic acid: N-riboside formation in vivo.


Metabolism of tetralin and toxicity of Cuprex in man.


Effect of adrenergic blockade on the duodenal motor reaction induced by some ions.


Metabolism of 2-ethyl-2-methylsuccinimide (ethosuximide) in the rat and human.


Structure-activity relationship studies on inhibition of histamine uptake by rabbit blood platelets.


Androgen assimilation by the epithelium and muscle of the guinea-pig seminal vesicle.


Dialkyl esters of methotrexate and 3',5'-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase.


Indirect alpha adrenergic response to isoproterenol in the dog spleen.


Excretion of 3H-digitoxin and its metabolites following spironolactone pretreatment in rats.


Selective beta adrenergic receptor antagonism in the anesthetized dog.


The distribution of chlorcyclizine-14C in pregnant mice.


The relationships between alpha receptor block, inhibition of norepinephrine uptake and the release and metabolism of 3H-norepinephrine.


Trans-synaptic induction of choline acetyltransferase in the preganglionic neuron of the peripheral sympathetic nervous system.


Editorial: A lesson from Gus.

Editorial: A lesson from Gus.


n-Octylamine difference spectra of cytochromes P-450 and P-448 from rat and mouse liver: a species difference.


The genetic control of molybdoflavoproteins in Aspergillus nidulans. II. Use of NADH dehydrogenase activity associated with xanthine dehydrogenase to investigate substrate and product inductions.


Melanin: a unique biopolymer.

Melanin: a unique biopolymer.


Effect of lymphoid tissue transplants on the intensity of an existing graft-versus-host reaction.


Experimental lobar pneumonia in canine lung grafts.


Inhibition of graft-versus-host reactions in mice by host-directed antibody. Effect of serum dose and immunoglobulin subclass.


Competitive antagonism between phenoxybenzamine and acetylcholine in isolated rat atria.


Contractile responses to phenylephrine and carbachol in circular rabbit fundus strips at varying external K+ AND Ca++ concentrations.


The uses and relative hazard potential of psychoactive drugs.


Further studies of the capsular polysaccharide of Pneumococcus Type II.


Probable 16 year course in a patient with thrombotic thrombocytopenic purpura.


Failure of corticosteroid in the treatment of Duchenne (pseudo-hypertrophic) muscular dystrophy. Report of a clinically matched three year double-blind study.


A perspective of peripheral health care.


Curling. The psychological value of the sport.


Aneurysm of the gastroduodenal artery: a cause of gastrointestinal bleeding.


Brown Recluse spider bite. Increasing incidents in Northern Illinois.


Common problems in high risk nurseries.

Common problems in high risk nurseries.


The viewbox. Dermatomyositis.

The viewbox. Dermatomyositis.


Cardiovascular collapse during gynecological laparoscopy.


Marcus P. Hatfield--the first pediatrician at Northwestern.


EKG of the month. Sinus rhythm and premature ventricular beats.


Surgical grand rounds: Tuberculosis of kidney.


Ulcerative colitis in Bombay.

Ulcerative colitis in Bombay.


Australia antigen and liver disease: a review article.


Problems and prospects for physician assistants in Ohio. Experience with the education of physician assistants in anesthesia in Cleveland.


Inhibition of hypertensive reflexes by propranolol.


Determination of diphenhydramine in plasma by gas chromatography.


Effect of quinoline, phthalazine and coumarin derivatives on the absorbance of NADPH.


Experimental cryptorchism: effect on serum LH and FSH in the rat.


Induction of heterotopic bone formation by demineralized dentin in guinea pigs: relationship to time.


High-dose urography in advanced renal failure. I. Evaluation of diagnostic value.


Oral contraceptives and psychiatric disturbance: evidence from research.


Hyperactive production of antibody of a boy with thymic dysplasia undergoing graft versus host reaction.


Immunoglobulin classes and IgG subclasses of human antinuclear antibodies. A correlation of complement fixation and the nephritis of systemic lupus erythematosus.


Mutants of Klebsiella aerogenes lacking glutamate dehydrogenase. A mutant of Klebsiella aerogenes lacking glutamate synthase activity (asm-200) is blocked in only one pathway of glutamate synthesis and can still use glutamate dehydrogenase to produce glutamate when ammonia in sufficient concentration, i.e., higher than 1 mM, is provided in the medium. However, a mutant that has neither glutamate synthase nor glutamate dehydrogenase activities (asm-200, gdhD1) requires glutamate. Transductants obtained by phage grown on wild-type cells of this double mutant, selected on medium containing less than 1 mM ammonia, regain glutamate synthase but not glutamate dehydrogenase. Surprisingly, these gdhD1 transductants grow as well in a variety of media as does a strain with glutamate dehydrogenase activity. Furthermore, transductions with these and other mutants indicate that the genes encoding glutamate synthase, glutamate dehydrogenase, glutamine synthetase, and citrate synthase are not closely linked.


Specificity of the autolysin of Streptococcus (Diplococcus) pneumoniae. A Streptococcus (Diplococcus) pneumoniae autolysin, partially purified from cellular autolysates, was optimally active at pH 7.0 and was stimulated by monovalent cations. Addition of autolysin to walls resulted in the appearance of only N-terminal l-alanine, whereas no glycosidase activity was observed. Walls which had been solubilized by autolysin were separated by gel filtration into a low-molecular-weight peptide containing amino acids in the same ratios found in intact walls and a high molecular fraction containing the amino acid-deficient peptidoglycan backbone. Thus, the major activity is an N-acetylmuramyl-l-alanine amidase. In addition, walls undergoing spontaneous lysis revealed no glycosidase activity but showed an increase in only N-terminal alanine. Autolysin, which was bound to walls in saline, was almost completely removed when walls were washed in distilled water, and all of the activity was recovered in the water wash fluid.


Early effects of monoamine oxidase inhibitors on dopamine metabolism and monoamine oxidase activity in the neostriatum of the rat.


Screening for galactosemia. Studies of the gene frequencies for galactosemia and the Duarte variant.


Effect of oxidized glutathione on protein synthesis.


Amidopyrine-N-demethylation by lung 9000 x g supernatant of newborn and adult rats.


Description and physiological characterization of a coryneform hydrogen bacterium, strain 14 g.


Laboratory colonization of Toxorhynchites brevipalpis. Toxorhynchites brevipalpis, a predator on larvae of Aedes aegypti and other mosquitos, was successfully colonized in the laboratory. At 25 degrees C, embryonic development was completed within 50 hours of oviposition, while larval and pupal development together took a further 27-41 days. The adult mosquitos mated in cages as small as 15x15x15 cm, and the embryonated eggs were obtained 6-31 days after the adults emerged.


New amino acids, and heterocyclic compounds participating in the Stickland reaction of Clostridium sticklandii.


Studies on partially purified pig liver steroid delta 4-5 beta-reductase activity.


The initiation of labor.

The initiation of labor.


Regulation by the precompetent cell culture of the appearance of spontaneous and induced competence.


Analgesia during labor: effect on the fetus and neonate.


Date on the enzyme histochemistry of the ependyma lining the infundibular and inframammillary recesses of the third cerebral ventricle, with special regard to the connexions of the tanycytes.


Effect of acetoacetate on liver and blood pyridine nucleotides in rats.


Distribution of tyrosine alpha-ketoglutarate transaminase activity in Kupffer cell and whole liver fractions of rat liver.


The reduction of methemoglobin in the human erythrocyte.


Mouse mixed lymphocyte reactions and cell-mediated lympholysis: genetic control and relevance to antigenic strength.


Workshop summary on genetic determinants of cell-mediated immune reactions in the mouse.


Genetic determinants for the graft-vs.-host reaction in the H-2 complex.


The histocompatibility complex of rhesus monkeys. 3. Evidence for a major MLR locus and histocompatibility-linked Ir genes.


Spleen cell transplantation in mice: influence of non-H-2 M locus on graft-vs.-host and host-vs.-graft reactions.


Procamine and other basic peptides in the venom of the honeybee (Apis mellifera).


The Ag-B locus rats: a major histocompatibility complex?


Serologic detection of antigens controlled by the Ir region of the H-2 complex in the mouse.


Activation of T cells by H-2 factors in the graft-vs-host reaction.


Alkali metal cations: effects on aggression and adrenal enzymes.


Separation of alkaline phosphatase isoenzymes and evaluation of the clinical usefulness of this determination.


Recurrent membranoproliferative glomerulonephritis with glomerular properdin deposition in allografts.


Histochemical studies of hepatic enzymes in dogs subjected to barbiturate anaesthesia.


Relationships of the catalytic properties of human plasma and platelet transglutaminases (activated blood coagulation factor XIII) to their subunit structures.


MMPI low-point codes for a "normal" young adult population: a normative study.


Collection of lymph from dog jejunal allotransplant. I. Cell transformation and lymphocytotoxicity against the host.


Separate versus full MMPI method: reliability of the pseudoneurologic scale.


Regulation of the antibody response to type 3 pneumococcal polysaccharide. 3. Role of regulatory T cells in the development of an IgG and IgA antibody response.


The effect of age on the response of rat lymphocytes in mixed leukocyte culture, to PHA, and in the graft-vs-host reaction.


Abbreviated MF and SI scales: efficacy with parents of emotionally disturbed children.


Use of surface-decalcified allogeneic bone and autogenous marrow in extensive mandibular defects.


Experimental kerosene pneumonia: evaluation of some therapeutic regimens.


Effect of synthetic luteinizing hormone-releasing hormone on the release of gonadotropins in hypophysogonadal disorders of children and adolescents. IV. Undescended testes.


Effects of various feeding and exercise regimens on rat growth and survival.


Hypoplastic pelvis in association with multiple anomalies.


Biochemical basis for nutritional management of preterm infants.


Analysis of photosynthesis in green algae through mutation studies.


The effects of long term administration of psychotropic drugs on human sleep. I. Methodology and the effects of placebo.


Circumvention of early graft-versus-host disease in hemiallogeneic bone marrow transplantation in a case of severe combined immunodeficiency.


Parabiosis in immunobiology.

Parabiosis in immunobiology.


Developmental defects of T and B cell lines in humans.


The depressant action of SKF 525A on the guinea-pig ileum.


Protection against isoprenaline induced myocardial necroses by beta-adrenergic blocking agents.


Primary pneumococcal peritonitis.

Primary pneumococcal peritonitis. A case of primary pneumococcal peritonitis in a girl of 9 is presented. The diagnosis was made at laparotomy and confirmed by immediate bacteriological examination. The condition is extremely rare and accounts for 1 in 5 of all cases of primary peritonitis in children.


Central action of 11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenzo-(b,e)oxepine hydrocholoride (doxepine).


Evaluation of hypnotics in outpatients with insomnia using a questionnaire and a self-rating technique.


Use of subjective responses to evaluate efficacy of mild analgesic-sedative combinations.


Beta-adrenergic receptor blockade as a protection against the death of hypoxia.


Solitary unicameral bone cyst of the calcaneus. A review of twenty cases.


Thymus dependence of lymphocyte trapping.


Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells.


Glomerulonephritis in the graft-vs-host reaction: serologic demonstration of anti-host antibodies.


Decline in suppressor T cell function with age in female NZB mice.


Editorial: Adventure at Anaheim.

Editorial: Adventure at Anaheim.


Proceedings: Rubidium salts: basic mechanisms of action.


Inspiratory versus expiratory efforts in pigeons: a search for selective drug influence.


A modified screening method for estimating erythrocyte glucose phosphate isomerase. A fluorimetric method to estimate erythrocyte glucose phosphate isomerase is described. Five mul of blood is added to 100 mul of water. Ten mul of the resulting hemolysate is incubated with a reaction mixture (200 mul) containing Tris-HCl buffer pH 8.0, 20 mumoles, MgCl(2) 2 mumoles, nicotinamide adenine dinucleotide phosphate 0.08 mumoles, glucose-6-phosphate dehydrogenase 0.2 EU and fructose-6-phosphate 0.12 mumoles. After ten minutes of 25 degrees C 20 mul of the mixture is added to 2 ml of 0.01 M phosphate buffer pH 7.4 and the nicotinamide adenine dinucleotide phosphate fluorescence determined. Two ml of water was added to the remaining reaction mixture and the hemoglobin concentration determined at 410 nm. The technique is primarily designed for use with small amounts of blood, of widely varying activity, from various animal species.


Galactose-I-phosphate uridyl transferase: a new manometric assay specially suited to erythrocyte studies in galactosaemia.


Editorial: The challenge.

Editorial: The challenge.


Interconversion of glycine and serine in a synaptosome fraction isolated from the spinal cord, medulla oblongata, telencephalon, and cerebellum of the rat.


Electrophysiological analysis of the actions of strychnine, bicuculline and picrotoxin on the axonal membrane.


Effect of high- and low-protein diets on the regulation of rat liver tyrosine aminotransferase and tryptophan oxygenase activities by L-tyrosine and L-tryptophan. Induction of rat liver tyrosine aminotransferase by l-tyrosine and tryptophan oxygenase by l-tryptophan was studied in groups of rats fed on diets containing 18 or 5% protein. The basal activity of hepatic tyrosine aminotransferase of rats receiving 5% protein gradually increased with the age of the animals but that of rats receiving 18% protein did not. l-Tyrosine induced hepatic tyrosine aminotransferase in rats receiving 18% protein when tested at ages from 4 to 20 weeks. When induction by l-tyrosine was carried out in rats receiving the 5% protein diet, significant induction of tyrosine aminotransferase occurred only in 4- or 6-week-old rats. Induction by l-tryptophan of tryptophan oxygenase in liver or the basal activity of this enzyme in liver did not differ between the groups fed on 5 and 18% protein. On changing the diet from 0 to 18% protein, the above-mentioned effects on the induction of hepatic tyrosine aminotransferase were reversed.


Beta-blockers and plasma renin activity in hypertension. Long-term treatment with propranolol was shown to produce a sustained suppression of the renin-aldosterone system in hypertensive patients, despite concurrent diuretic treatment. However, the antihypertensive effect of this treatment correlated poorly with its effects on plasma renin activity and urinary aldosterone excretion. When prindolol, another beta-adrenergic blocking drug, was substituted for propranolol, blood pressure control was retained, but there was a prompt rise in plasma renin activity, which was not attributable to changes in electrolyte balance. These observations suggest that the antihypertensive action of propranolol and other beta-blockers does not result from their effects on plasma renin activity.


Editorial: First aid for poisoning.

Editorial: First aid for poisoning.


3. The use of medical assistants in Rhodesia.


Comparative mechanisms of action of antiarrhythmic drugs.


Diseases of the skin. Drug therapy of urticaria. Most patients with urticaria can be assessed by taking a relatively simple history with few or no investigations and controlled by a suitable antihistamine given at appropriate times until spontaneous resolution occurs without a complete diagnosis ever being made. Those that do not respond in this way require sometimes quite elaborate investigations, the institution of which would be an imposition in a mild case. Even after full investigation and ringing the changes of all available drugs, too many cases persist to the frustration of all concerned.


Subgroups among opiate addicts: a typological investigation.


Effect of maleic acid on the ultraviolet absorption of some antihistamine maleate salts.


Letter: Colds and antihistaminic effects of vitamin C.


Nursing care study: polyarteritis nodosa.


Kinetic studies on the enzymes catalysing the conversion of 17alpha-hydroxyprogesterone and dehydroepiandrosterone to androstenedione in the human adrenal gland in vitro.


Laboratory personnel: the most important aspect of quality control.


Seventeen year old man with marked eosinophilia and blue toes.


Withdrawal of maintenance drugs with long-term hospitalized mental patients: a critical review.


Radiosensitivity of lymphocytes.

Radiosensitivity of lymphocytes.


Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon.


The effects of ritodrine hydrochloride on uterine activity and the cardiovascular system.


Double blind cross-over study of the inotropic influence of Tiprenolol (DU21445) and propranolol in patients with ischaemic heart disease.


A ceramide tetrasaccharide of human erythrocyte membrane reacting with anti-type XIV pneumococcal polysaccharide antiserum.


Conventions and income tax.

Conventions and income tax.


Effects of phenobarbital, 3-methylcholanthrene, and griseofulvin on the O-demethylation of griseofulvin by liver microsomes of rats and mice.


Utilization of fluorides in areas lacking central water supplies.


Graft-vs.-host reactions in reciprocal hybrid mice. I. Dissociation of T-cell activities in the mixed lymphocyte reaction and two graft-vs.-host assays. Spleen cells from BALB/c and C57BL/6 mice were tested for their reactivity against reciprocal hybrid tissues ((BALB/c x C57BL/6) F(1) and (C57BL/6 x BALB/c) F(1)) in three assay systems: the mixed lymphocyte reaction (MLR); the Simonsen spleen-weight graft-vs.-host (GVH) assay; and a GVH mortality assay. It was shown that both F(1)'s serve as equally effective stimulators of parental cells in the MLR. In the spleen-weight assay, BALB/c and C57BL/6 cells were equally active in a given host, but greater splenomegaly was observed in (BALB/c x C57BL/6) F(1) hosts regardless of the donor strain. By contrast, BALB/c cells were much less lethal than C57BL/6 cells in (BALB/c x C57BL/6) F(1) hosts than in (C57BL/6 x BALB/c) F(1) hosts, and to a lesser degree C57BL/6 cells were less lethal than BALB/c cells in (C57BL/6 x BALB/c) F(1) hosts. The possibility that modifying substances may differentially alter reactivity of parental lymphocytes and that considerations other than genotype determine the outcome of a GVH reaction are discussed in detail.


Metabolism of 4-(3-(dimethylamino)propyl)-3,4-dihydro-2-(1-hydroxyethyl)-3-phenyl-2H-1,4-benzothiazine (SQ 11,579) under in vitro and in vivo conditions by rats, dogs, and monkey.


Changes in rate of ethanol elimination associated with chronic administration of ethanol to chimpanzees and rhesus monkeys.


Immunological tolerance. Dissociation between in vivo and in vitro reactivity in parabiosed mice. Although most mouse strain combinations succumb to a lethal wasting disease when parabiosed across a strong histocompatibility (H-2) barrier, a high proportion of DBA mice parabiosed to DBA/C3H F(1) hybrids survive and appear healthy. DBA mice accept C3H skin grafts following parabiosis, and may therefore be considered operationally tolerant of C3H antigens. Nonetheless, spleen cells from long-term DBA and F(1) parabionts give normal and enhanced responses, respectively, to C3H antigens in mixed lymphocyte culture (MLC). This indicates that the tolerance mechanism can distinguish between MLC recognition reactivity and in vivo effector reactivity, and that the former can therefore exist in the absence of the latter.


The effect of particulate dispersing agents on the antifoaming properties of dimethicone 1000 in antiflatulent products.


An infrared study of the interaction between Aerosil-200 and polydimethylsiloxane (dimethicone-1000).


Kinetics of microsomal metabolism and binding of enantiomerically related substrates.


Disposition and metabolism of thiopurines. II. Arabinosyl-6-mercaptopurine and ribosyl-6-mercaptopurine.


The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane.


The effects of phospholipase C on excitation-contraction coupling mechanisms in smooth muscle.


The relationship between the metabolism of 2,4-dichloro-6-phenylphenoxyethylamine (DPEA) and related compounds and their activities as microsomal mono-oxygenase inhibitors.


The bronchoconstrictor action of the tetradecapeptide bombesin in the guinea-pig.


The effect of carbenicillin on the haemostatic mechanism.


Anti-inflammatory activity in human plasma.


The binding of conformationally restricted antihistamines to histamine receptors.


Stereochemical and structural assignment to benzomorphans by mass spectrometry.


The use of radioisotopically labelled methyl esters in the determination of the 15-epimer content of prostaglandins.


Letter: Effect of substituted tryptamines on the efflux of noradrenaline from adrenergic nerves in rabbit atria.


Letter: The effect of D- and L-p-chlorophenylalanine on the metabolism of 5-hydroxytryptamine in brain.


Letter: Reduction of food intake by apomorphine: a pimozide-sensitive effect.


Letter: Cerebral phosphodiesterase and the dopamine receptor.


Letter: The effect of papaverine on 45Ca2+ uptake in partly depolarized taenia coli of the guinea-pig.


Letter: The effect of cannabidiol on maximal electroshock seizures in rats.


Letter: Comparison of the relaxant effects of isoprenaline and tolbutamide on uterine and tracheal muscle.


Letter: Application of mass spectrometry to enzyme inhibition studies.


Decreased histamine synthesis in the rat brain by hypnotics and anaesthetics.


Letter: Chemical antagonism by iodine of the pharmacological activity of some sympathomimetic amines.


Letter: Effect of chlorimipramine on the rate of tryptophan hydroxylation in the intact and transected spinal cord.


Induction of UDP glucuronyltransferase in the liver and extrahepatic organs of the rat.


Response of the mixed function oxidase system of rat hepatic microsomes to parathion and malathion and their oxygenated analogs.


Studies on a non-pyridine nucleotide dependent, membrane-bound L-(+)-glutamate oxidoreductase in Azotobacter vinelandii.


Observations on the binding site for antimalarial schizontocides.


Investigations of the utilization of NADPH for steroid hydroxylations by adrenal cortex mitochondrial enzymes.


Effects of the noradrenaline metabolites on tyrosine hydroxylase activity in guinea-pig atria.


1. The effect of heparin on the migration of Brugia pahangi microfilariae Culex pipiens. 2. The uptake of B. pahangi microfilariae in C. pipiens and the infectivity of C. pipiens in relation to microfilarial densities. 3. Evidence of a sex-linked recessive gene, sb, controlling susceptibility C. pipiens to B. pahangi.


An improved method for studying the psychogalvanic reaction in mice and its inhibition by psycholeptic drugs. Comparison with the effects of other pharmacological agents.


A review of the scorpions of East Africa with special regard to Kenya and Tanzania.


Detection of Trypanosoma theileri in Ethiopian cattle ticks.


The penetration of the peritrophic membrane of the tsetse flies by trypanosomes.


Serological identification of reptile feeds of Glossina.


Observations on the activity cycle of Glossina swynnertoni Aust.


Ophthalmomyiasis due to Oestrus ovis.

Ophthalmomyiasis due to Oestrus ovis.


Upper-respiratory tract complaint protocol for physician-extenders.


Hay fever research: a brief review. A.

Hay fever research: a brief review. A.


Surveillance of Venezuelan equine encephalitis in the United States--1972.


Preliminary report on the haemodynamic response of hypertensive patients treated with a beta blocker (ICI 66082).


Cardiac actions of oxprenolol as studied in dog heart-lung preparations.


The effects E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat. 1. The effects of prostaglandins E(1), E(2), A(1) and A(2) on gastric acid secretion and mucosal blood flow were studied by means of a [(14)C]-aniline clearance technique in the anaesthetized rat.2. During intravenous administration of these prostaglandins, in doses which almost completely inhibited pentagastrin- and histamine-induced acid secretion, a fall in clearance was observed.3. Clearance per unit acid secretion increased during prostaglandin administration, precluding a primary reduction in mucosal blood flow as the mechanism of the antisecretory action.4. Prostaglandins increased clearance during basal secretion, indicating a direct vasodilator effect on the gastric mucosa.5. The possibility that endogenous prostaglandins contribute to functional vasodilatation in the gastric mucosa and that exogenous prostaglandins may be of clinical value in the treatment of peptic ulcer is discussed.


Editorial: New developments in the treatment of bronchial asthma.


Isoprenaline- and exercise- induced tachycardia in the assessment of beta-adrenoceptor blocking drugs; a comparison between tolamolol, practolol and propranolol. The effects of tolamolol, propranolol and practolol on both isoprenaline- and exercise-induced tachycardia have been studied in conscious dogs. Tolamolol was approximately equipotent to propranolol and 50 times more potent than practolol in antagonizing exercise-induced tachycardias, but was approximately 12 times less potent than propranolol and 8 times more potent than practolol in blocking isoprenaline-induced tachycardia. It is suggested that antagonism of the tachycardia induced by exercise affords a more meaningful assessment of the possible therapeutic potential of beta-adrenoceptor blocking drugs than does that induced by isoprenaline.


Symposium on allergic lung disease. V. Selective drug treatments for bronchial asthma. This paper presents a brief summary of the evidence for selective beta-stimulant and selective glucocorticoid treatments of bronchial asthma. If they are used together correctly, and with sodium cromoglycate in suitable cases, the physician will achieve better control of bronchial asthma in most patients.


Adrenergic blocking agents.

Adrenergic blocking agents.


Phenothiazines and other tranquilizers.

Phenothiazines and other tranquilizers.


Vasopressors and low-flow states.

Vasopressors and low-flow states.


The Medicines Commission's proposed 'prescription only' list. The Medicines Commission's proposals, in light of the 1968 Medicines Act, regarding prescription-only drugs are noted, and several criticisms are offered.  The Act was designed to provide a coherent and comprehensive system for determining what drugs require a prescription.  The 2 types of exemptions proposed were: 1) allowing pharmacists to provide a prescription-only drug in an emergency with the doctor providing a prescription within 72 hours, and 2) allowing pharmacists to provide a 3-day emergency supply of  drugs previously ordered by a physician.  It is felt that some modification is necessary in this proposal; e.g., a parent might not be able to obtain the drugs for a child as the proposal now stands.  Oral contraceptives remain on the list of prescription drugs although many people think they should not.  2 main groups of drugs were removed from the prescription-only group: most antihistamines and most antimalarials.  These 2 omissions have caused some concern, and it is recommended that they be returned to the prescription-only list.  The third definite group is the drugs that would not be supplied without a prescription even in an emergency; this group includes drugs that contain opiates, barbiturates, hypnotics, and all major tranquilizers.


Preparation of a patient with cardiovascular disease for surgery.


The disposition of propranolol. VII. The effects of saturable hepatic tissue uptake on drug clearance by the perfused rat liver.


Determination of apparent kinetic constants of the microsomal hydroxylation of amobarbital, hexobarbital, and pentobarbital.


Myocardial depression during Diplococcus pneumoniae infection in monkeys.


Effects of spironolactone on carbon tetrachloride hepatotoxicity.


The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.


Current trends in the treatment of hypertension.


Liver microsomal hydroxylation of steroid hormones after establishing an indigenous microflora in germfree rats.


Metabolic disposition of thiamine tetrahydrofurfuryl disulfide in dog and man.


Species differences in the metabolism of orally administered dopamine-14C and N-alanyldopamine-14C.


Mechanism of action and pharmacological classification of beta-adrenergic receptor blocking drugs.


Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine.


Beta-adrenergic blockade in ischaemic heart disease.


Beta blockade in supraventricular arrhythmias.


Effects of various centrally active drugs on hepatic microsomal enzymes: a comparative study.


Warfarin metabolism in the guinea pig. I. Pharmacological studies.


Immunodiffusion studies of pneumococcal antigens with special reference to serotype 27.


Beta-adrenergic blocking agents in hypertrophic cardiomyopathy (HOCM).


History of the once close relationship between electrotherapeutics and radiology.


A schema for immunotherapy.

A schema for immunotherapy.


Diphenylhydantoin metabolism. A prospective review.


Social and psychological characteristics of heroin addicts dropping out of methadone treatment.


Some etiological factors in phobic neurosis.


Treatment of seasonal allergic rhinitis with 2 percent sodium cromoglycate (BP) solution.


Frequency of clinical toxicology test-ordering (primarily overdose cases) and results in a large urban general hospital.


Effect of riboflavin deficiency on liver microsomal enzyme system and lipid peroxidation in male rats.


Age dependent determinations of lysosomal enzyme activities in the liver and brain as well as the measurements of cytoplasmic enzyme activities in the blood of piracetam pre-treated rats.


Stabilization of rat liver tyrosine aminotransferase by drugs.


Motorcycle foot. A case report.

Motorcycle foot. A case report.


The athlete's dilemma.

The athlete's dilemma.


Determination of thermodynamics of halogen groups in solutions of drug molecules.


The influence of solution viscosity on the dissolution rate of soluble salts, and the measurement of an "effective" viscosity.


The tautomer ratio of histamine.

The tautomer ratio of histamine.


Gas-liquid chromatographic estimation in blood of ICI 58 834.


Dextromethorphan-monoamine oxidase inhibitor interaction in rabbits.


The 5-hydroxytryptamine content of rabbit hearts and its release during in vitro perfusion.


Evidence for catecholamine involvement in the suppression of locomotor activity due to hypoxia.


Pipradrol in mild depression: a controlled study.


Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf. var cumminsii (Stapf.) H. Huber.


Letter: Effect of emetine treatment on tissue transaminase activity.


Letter: Transmitter release by red back spider venom.


Letter: Effect of some lipid-soluble derivatives of amphetamine on amphetamine levels in rat brain.


Letter: Effect of lithium carbonate and alpha-methyl-p-tyrosine on audiogenic seizure intensity.


Letter: Ulcerogenic potential of indomethacin in arthritic and non-arthritic rats.


Letter: 3-methoxyisoprenaline: a potent selective Uptake2 inhibitor.


Letter: Monoamine tetrazolium reductase of rat heart mitochondria.


Letter: More on the blockade of neural and exogenous noradrenaline in vascular tissue.


Letter: Effect of phenylethanol on Pseudomonas aeruginosa.


Letter: Effects of dopamine receptor stimulation and blockade on Ro 4-1284-induced enhancement of electroshock seizure.


Letter: Nuclear magnetic resonance studies of cetomacrogol 1000-benzaldehyde-propyl gallate interactions.


Letter: The influence of chain length upon the activity of 5-hydroxytryptamine.


Adrenergic-induced vascular adjustments--initial and escape reactions. II. Role of beta-adrenergic receptors within different sections of the isolated intestinal vascular bed.


Adrenergic-induced vascular adjustments--initial and escape reactions. I. Influence of beta-adrenergic blocking agents on the intestinal circulation of the rat (in vivo).


The subjective experience of perceptual and cognitive disturbances in schizophrenia. A review of autobiographical accounts.


Diazepam on demand. Drug-seeking behavior in psychiatric inpatients.


The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. 1. Kinetic experiments suggested the possible existence of at least two different NAD(+)-dependent aldehyde dehydrogenases in rat liver. Distribution studies showed that one enzyme, designated enzyme I, was exclusively localized in the mitochondria and that another enzyme, designated enzyme II, was localized in both the mitochondria and the microsomal fraction. 2. A NADP(+)-dependent enzyme was also found in the mitochondria and the microsomal fraction and it is suggested that this enzyme is identical with enzyme II. 3. The K(m) for acetaldehyde was apparently less than 10mum for enzyme I and 0.9-1.7mm for enzyme II. The K(m) for NAD(+) was similar for both enzymes (20-30mum). The K(m) for NADP(+) was 2-3mm and for acetaldehyde 0.5-0.7mm for the NADP(+)-dependent activity. 4. The NAD(+)-dependent enzymes show pH optima between 9 and 10. The highest activity was found in pyrophosphate buffer for both enzymes. In phosphate buffer there was a striking difference in activity between the two enzymes. Compared with the activity in pyrophosphate buffer, the activity of enzyme II was uninfluenced, whereas the activity of enzyme I was very low. 5. The results are compared with those of earlier investigations on the distribution of aldehyde dehydrogenase and with the results from purified enzymes from different sources.


Aromatic amino acid transaminase in rat intestine. The transamination of aromatic l-amino acids (5-hydroxytryptophan, tryptophan, tyrosine, phenylalanine and kynurenine) was shown to be catalysed by enzyme preparations from rat small intestine. On the basis of the partial purification and characterization of these aromatic amino acid transaminases, it is suggested that rat small intestine contains several kinds of aromatic amino acid transaminases.


Assay for glutamine synthetase activity. The use of phosphoenolpyruvate plus pyruvate kinase as an ATP-generating system in the assay for glutamine synthetase activity via the formation of gamma-glutamylhydroxamate from glutamate and hydroxylamine with crude tissue preparations is shown to give values far in excess of the true glutamine synthetase activity of the tissue. This is due to the generation of pyruvate, which reacts with hydroxylamine to give a compound that is chromogenic with the ferric chloride reagent used for measuring gamma-glutamylhydroxamate.


The mechanism of the oxidation of ascorbate and MN2+ by chloroplasts. The role of the radical superoxide.


Prolonged drug-induced Parkinsonism.

Prolonged drug-induced Parkinsonism.


Late changes in the enzymatic activity of the neuroglia as a sequel to acute hydrogen cyanide poisoning.


Regulation of tyrosine aminotrasferase activity in two liver-derived permanent cell lines. The regulation of tyrosine aminotransferase (TAT) activity has been examined in two liver-derived heteroploid cell lines. One (hepatoma tissue culture cells [HTC]) was derived from a hepatoma, the other (rat liver culture cells [RLC]) was derived from normal liver. The two cell lines show the following striking similarities in the control of this specific protein: (a) The kinetics of TAT induction by dexamethasone phosphate (DxP) are similar in randomly growing cells of both lines; (b) During mitosis and early G(1) phase of the cell cycle TAT activity cannot be induced by DxP in either cell line; (c) 2-3 h into G(1), when both lines become sensitive to inducer, basal enzyme activity declines to a new steady-state level; (d) Preinduced cells collected in mitosis show approximately twice the level of TAT activity as fully induced, randomly growing cultures and this activity is maintained in early G(1) with or without the inducer; and (e) Inhibition of RNA synthesis by 5 microg/ml of actinomycin D in preinduced, synchronized cells allows TAT activity to remain at constitutive levels throughout G(1), even in the absence of inducer. These results are presented in support of a previously described model which states that glucocorticoid hormones exert posttranscriptional control of the synthesis of specific proteins in mammalian cells.


Anticancer activity of zoanthids and the associated toxin, palytoxin, against Ehrlich ascites tumor and P-388 lymphocytic leukemia in mice.


Establishment of a clonal strain of hepatoma cells which maintain in culture the five enzymes of the urea cycle.


Some effects of experimental Fasciola hepatica infection in cattle on the serum activities of gamma-glutamyl transpeptidase and glutamic oxaloacetic transaminase.


Metabolism of 2-hydroxy(4-14C)estradiol by rat liver microsomes.


Filariasis vectors in the Western Pacific region.


Therapeutische Indikationen für Agedal-Randolectil.


Pneumococcal infections of the eye.

Pneumococcal infections of the eye.


Pharmacologic studies on propynyl dibenzazepine, a new alpha adrenergic blocker.


Anticonvulsant testing with a new analeptic convulsant: N-sulfamoyl-hexahydro-azepine (Sah 41-178).


Chlorpromazine metabolism. VI. Adrenolytic and antiserotonergic activities of chlorpromazine and its various metabolites.


Bronchospasmolytic activity of some prostaglandins in the guinea-pig.


Hepatic coma in cirrhosis, portal hypertension, and following portacaval shunt. Its etiologies and the current status of its treatment.


Comparison of the chronic and acute effects of D-lysergic acid diethylamide (LSD) treatment on rat brain serotonin and norepinephrine.


Development of carcinoma in regional enteritis.


Precocious induction of hepatic aniline hydroxylase and aminopyrine N-demethylase with hydrocortisone in neonatal rat.


Reduction of chloral hydrate to trichloroethanol in brain extracts.


Interaction of concanavalin A with the capsular polysaccharide of pneumococcus type XII and isolation of kojibiose from the polysaccharide.


Conformation of porcine D-amino acid oxidase as studied by protein fluorescence and optical rotatory dispersion.


Factors affecting the folding and association of flounder muscle glyceraldehyde-3-phosphate dehydrogenase, in vitro.


Enhancing effect of glutamate on apparent serum gamma-glutamyltranspeptidase activity.


The application of invertebrate tissue culture to the in vitro study of animal parasites.


Some psychological factors in Parkinsonism. Twenty-four Parkinsonism patients were compared with `normal controls' and with another chronically disabled group, matched for age, sex distribution, and socioeconomic background, on measures of depression and some intellectual factors. A tendency to depression in the Parkinsonism sufferers was demonstrated together with an apparent specific intellectual deficit, for which a cause related to the motor disabilities of the disease is postulated.


Ultrastructure of the glomerular basement membrane in long term renal allografts with transplant glomerular disease.


Cyclic AMP concentration in saliva of normal children and children with Downs syndrome.


Effect of trauma and hydrocortisone on liver tyrosine-alpha-ketoglutarate transaminase activity of rats adapted to noble-collip drum trauma.


Analytical isotachophoresis in capillary tubes used for the separation of ions involved in the enzymatic transformation of glucose to 6-phosphogluconate.


Cerebrospinal vascular wall lesions causing nervous symptoms in swine (Harding's cerebrospinal angiopathy).


Improved purification, amino acid analysis and molecular weight of homogenous D-amino acid oxidase from pig kidney.


Purification and characterization of yeast thioredoxin reductase.


Guanosine 5'-phosphate reductase of human erythrocytes.


An interaction between S-adenosyl-L-methionine and pyridoxal 5'-phosphate, and its effect on Saccharomyces cerevisiae.


Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption.


Trans-synaptic enzyme induction.

Trans-synaptic enzyme induction.


Antipsychotic agents.

Antipsychotic agents.


Meteorological effects on arthropods (including insects, ticks and mites) as vectors of human and animal diseases.


Collar cells in planula and adult tentacle ectoderm of the solitary coral Balanophyllia regia (Anthozoa Eupsammiidae).


On the relation of cyclic AMP to adrenergic receptors and sympathin.


Clinical conference: Hypertension.

Clinical conference: Hypertension.