Kinetics of the inhibitory effect of pepstatin on the reaction of hog renin with rat plasma substrate.


The "Nona" electrocardiogram: findings in 100 patients of the 90 plus age group.


Histologic evidence for lipids during human tooth movement.


Angio-immunoblastic lymphadenopathy with dysproteinaemia.


Prospective study of outpatients with extensive colitis.


Outcome in offspring of chronic alcoholic women.


Plasma-immunoreactive-calcitonin in patients with non-thyroid tumours.


Immediate effects of feeding on blood-gases and some cardiorespiratory functions in ill newborn infants.


Humoral and cell-mediated intrinsic-factor antibody in pernicious anaemia.


Arterial prosthesis of lyophilised human dura origin: healing fate; scanning electron microscopy and fibrinolytic autography of graft endothelium.


Editorial: Tuberculosis retreats--slowly.


Editorial: Follicular lymphomas.

Editorial: Follicular lymphomas.


Editorial: Malaria vaccine: promise or phantom.


Editorial: Children in danger.

Editorial: Children in danger.


Editorial: Obstetric analgesia and the newborn baby.


Impact of the Sahelian drought in Mauritania, West Africa.


How efficient is immunological surveillance against cancer and why does it fail?


Letter: Brittle diabetes.

Letter: Brittle diabetes.


Letter: The isolation of hospitals for the mentally handicapped.


Letter: Nothing much for the nurses.

Letter: Nothing much for the nurses.


Letter: Geriatrics is medicine.

Letter: Geriatrics is medicine.


Letter: Treatment of acute myocardial infarction.


Letter: Prevention of coronary heart-disease.


Letter: Relevance of the relevant in teaching.


Letter: Shoulder-hand syndrome.

Letter: Shoulder-hand syndrome.


Letter: Serum F.T.I. and T.S.H. in iodine-131 treated hyperthyroidism.


Letter: Human calcitonin, serum-phosphate, renal failure.


Letter: Virus in faecal extracts from children with gastroenteritis.


Letter: Force feeding of prisoners.

Letter: Force feeding of prisoners.


Letter: Beta-trace protein and neural-tube defects.


Letter: Towards the prevention of spina bifida.


Letter: Cholera.

Letter: Cholera.


Letter: Thalidomide and embryonic neuropathy.


Letter: Congenital anomalies and anti-social behaviour possibly related to microbial contamination of diet.


Letter: Pathogenesis of Huntington's chorea, Pick's disease, and paralysis agitans.


Letter: Anti-epileptic drugs and failure of oral contraceptives.


Letter: S.S.P.E. and multiple sclerosis.


Letter: Acute leukaemia and myeloma.

Letter: Acute leukaemia and myeloma.


Letter: Hospital service for children with infective diseases.


Letter: Acid-base changes during treatment of diabetic ketoacidosis.


Letter: Lymphocyte response.

Letter: Lymphocyte response.


Letter: Colon cancer and blood-cholesterol.


Letter: Lithium in Parkinson's disease.

Letter: Lithium in Parkinson's disease.


Letter: Reverse transcriptase in acute leukaemia.


Letter: Antral-gastrin-cell hyperplasia in peptic-ulcer disease.


Letter: Mo91--an allele at the first HL-A locus.


Letter: Arachidonic acid and retinal pigmentary degeneration.


Letter: Hyponatraemia.

Letter: Hyponatraemia.


Letter: Fetoscopy followed by live birth.


Letter: HL-A and disease.

Letter: HL-A and disease.


George Herbert Harry Benham.

George Herbert Harry Benham.


Urinary protein components. 3. Classification of proteinuria based on the protein clearance results.


Investigations of ageing in costal and tracheal cartilage of rats.


The ninth retinula cell in the ommatidium of the worker honey bee (Apis mellifica L.).


The surface film on the mesothelium of the serous membranes of the rat.


Effect of temperature on the function of a proton pump.


The influence of radiation on blood vessels and circulation. Chapter IX. Blood flow and permeability in the central nervous system.


AV techniques in CPR teaching.

AV techniques in CPR teaching.


Thermally-induced changes in chromatin of isolated nuclei and of intact cells as revealed by acridine orange staining.


Transfer factor: a subcellular component that transmits information for specific immune responses. Two transfer factors have been prepared in an animal model system, the guinea pig. They are both small molecules, derived from the leukocytes of immunologically experienced individuals, and capable of transferring information for specific immune responses to naive individuals.


Androgen receptor in rat liver: hormonal and developmental regulation of the cytoplasmic receptor and its correlation with the androgen-dependent synthesis of alpha2u-globulin.


An immunosuppressive peptide fraction in the serum of cancer patients.


Evidence for non-identity of T killer and T helper cells sensitised to allogeneic cell antigens.


Functional characterization of blocking antibody after human renal transplantation.


Type-specific protein in herpes simplex virus envelope reacts with neutralising antibody.


Expression of M locus differences by B cells but not T cells.


The interference of human IgG with the double-antibody radioimmunoassay of thyrotrophic hormone and its clinical significance.


Alcoholic aniline blue as a stain for deoxyribonucleic acid in the Feulgen procedure.


A pedunculated middle lobe of the prostate gland.


Dipetalonema semiclarum sp. nov. from the blood of man in the Republic of Zaire (Nematoda : Filarioidea).


Raman spectroscopic investigation of gramicidin A' conformations. Gramicidin A' is believed to form transmembrane channels in lipid bilayers and biological membranes. The first Raman spectroscopic study of gramicidin A' is presented. Evidence is found for two types of conformation. One type is found in the powder and has a Raman spectrum similar to that of model polypeptides with beta hydrogen bonding. The second type is found when gramicidin A' is dissolved in dimethyl sulfoxide.


Immunotherapeutic suppression in transplantable solid tumours.


Immune cytolysis of human tumor cells mediated by xenogeneic "immune" ribonucleic acid: implications for immunotherapy.


Rescue of defective SV40 from mouse-human hybrid cells containing human chromosome 7.


Effects of thyroxine, growth hormone, and pituitary homogenates on insulin secretion and glucose uptake in thyroidectomized rats.


Early regression of the progestational response in rabbits after administration of progestins in the estrogen priming phase.


A new look at audiovisual teaching.

A new look at audiovisual teaching.


Microspectrophotometric studies on the staining of DNA with violet rosaniline.


The rosettes and the immuno-cyto-adherence: analytic essay.


Trypsin inhibition in urine of developing neonatal pigs and in sow's colostrum.


Lymphocyte plasma membranes. II. Cytochemical localization of 5'-nucleotidase in rat lymphocytes.


Tumor scanning agents.

Tumor scanning agents.


A visual aid to the classification of oral contraceptives. A method for classifying oral contraceptive preparations is presented.  The comparative potency of estrogen and progestogen in any formulation is plotted on coordinate axes.  The point representation for the formulation in question will thus reflect the overall potency, character, and types of possible side effects for a particular oral contraceptive.  Illustrations show how to use this system for both contraceptive and infertility therapy.


Fluorescent bodies in the spermatozoa of patients with sterility.


A new formula for a half-oxidized hematoxylin solution that neither overstains nor requires differentiation.


Abrogation of cell-mediated immunity by hyperimmune alloantiserum: mechanisms and correlation with allograft enhancement.


Papanicolaou smear of cultured human tumor cells.


Neisseria gonorrhoeae in Papanicolaou smears.


Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. 1. Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.


The effect of visual feedback on physiological muscle tremor.


Emitted cerebral events.

Emitted cerebral events.


Computer analysis of rabbit EEG after cerebral ischemia.


Asymmetries in the electroencephalogram associated with cerebral dominance.


Electromyography during voluntary movement: the two-burst pattern.


Generalized penicillin epilepsy in the cat: effects of intracarotid and intravertebral pentylenetetrazol and amobarbital injections.


Generalized penicillin epilepsy in the cat: effect of midbrain cooling.


Simultaneous averaging of epileptic discharges in 14 channels: a computer technique.


Technique of reconstruction of a cerebral hemisphere from serial sections.


Somatosensory responses to stimulus trains: normative data.


Somatosensory response to stimulus trains in patients with multiple sclerosis.


A very stable electrode system for recording human scalp potentials with direct-coupled amplifiers.


Bypassing the obstructed superior vena cava with a subcutaneous long saphenous vein graft.


Centromeric heterochromatin and comparison of G-banding in cattle, goat, and sheep chromosomes (Bovidae).


Translocation of centromeric heterochromatin in the T(10;13) 199H stock of Mus musculus and localization of chromosome break points.


Giemsa-banded chromosomes of mouse myeloma in relationship to oncogenicity.


Protein granules in glial and ependymal cells in the hypophysiotropic area of the rat, stainable with aldehyde-fuchsin and chrome alum-hematoxylin.


Spectral and multivariate analysis of EEG changes during mental activity in man.


Average transmission distance from mitral-tufted to granule cells in olfactory bulb.


Evoked potentials of the central visual system during and after hypoxia in cats.


Electro-oculographic abnormalities during pursuit movements in developmental dyslexia.


Sleep patterns in a patient with a brain stem infarction involving the raphe nucleus.


The effect of deep hypothermia and total circulatory arrest on the electroencephalogram in children.


A remote-control leucotome for neurophysiological experimentation.


Epidural electrode for animals with thin skulls.


Haemoglobin synthesis in inducible, uninducible and hybrid Friend cell clones.


The in vivo reproductive potential of density separated cells.


Relationship of age of normal dogs to blood serum constituents and reliability of measured single values.


Biophysical studies on the mechanism of quinacrine staining of chromosomes.


Acting out and unusual behavior in schizophrenia.


Distribution of heavy metals in the hippocampal region of the guinea pig. A light microscope study with Timm's sulfide silver method.


Ultrastructural studies on the coronet cells of the saccus vasculosus of the freshwater stickleback, Gasterosteus aculeatus form leiurus.


Pancreatic cancer. Initial treatment as the determinant of survival.


Delayed light studies on photosynthetic energy conversion. VII. Effect of the high energy state, coupled to 2,3,5,6-tetramethyl p-phenylenediamine-catalyzed cyclic electron flow, on millisecond emission from chloroplasts and digitonin subchloroplast particles.


Polymorphic nature of the human Rho (D) antigen among the red cells of non-human primates.


Blood groups of non-human primates. Summary of the currently available information.


Immunological and structural studies of immunoglobulins of human, chimpanzee and other non-human primates.


Implications of studies in chimpanzees for the serology of the human Rh-Hr blood types.


Blood group antigens in primate animals and their relation to human blood groups.


Trophic functions of the neuron. 3. Mechanisms of neurotrophic interactions. The role of acetylcholine as a neurotropic transmitter.


Trophic functions of the neuron. 3. Mechanisms of neurotrophic interactions. Systems of material transport in nerve fibers (axoplasmic transport) related to nerve function and trophic control.


Trophic functions of the neuron. VI. Other trophic systems. The influence of the periphery on spinal motor neurons.


[Quantitative determination of proteins in the aqueous humor and the vitreous body of the rabbit].


Isolation of skin test-active preparations from yeast-phase cells of Blastomyces dermatitidis. Cell wall and cytoplasmic fractions were isolated from mechanically disrupted yeast-phase cells of Blastomyces dermatitidis in an effort to obtain a reliable skin-test antigen. The biological activities of these fractions were compared with those of two blastomycin preparations. The cytoplasmic antigens exhibited a low index of specificity yet exceeded the specificities of the blastomycins. The skin test-active component(s) of the cytoplasmic material had a molecular weight between 10,000 and 30,000 and could easily be concentrated by ultrafiltration on a PM-10 membrane. Unlike the cytoplasmic antigens and blastomycins, an alkali-soluble, water-soluble cell wall antigen effectively distinguished guinea pigs that were sensitized to B. dermatitidis from those sensitized to Histoplasma capsulatum. The biological activity of the yeast-phase antigen could be quantitated, on a weight basis, after purification by ultrafiltration (PM-10 membrane).


Observations on mammalian pancreatic cells grown in monolayer cultures. V. Quantitative study of the nucleolar extrusion in rat pancreatic cells cultivated in vitro.


Letter: Cytochrome c and cytochrome oxidase in diaminobenzidine staining of mitochondria.


Ovarian tumor-specific antigens.

Ovarian tumor-specific antigens.


Absence of the 9q plus chromosome in Ph1 negative chronic myelogenous leukaemia.


Microphotometry of banded human chromosomes. High resolving power by direct scanning of the specimen compared with scanning on microphotographs.


Folic acid effects on glycoprotein-galactosyltransferase: a re-assessment.


Histocompatibility-linked genetic control of specific immune responses to viral infection.


Transcription of heteropolymeric regions of avian myeloblastosis virus high molecular weight RNA with Escherichia coli DNA polymerase I.


Passive enhancement of canine renal allografts with polyspecific F(ab')2 fragments.


Are 'N bands' selective staining of specific heterochromatin?


Nucleotide sequences of human globin messenger RNA. Globin messenger RNA, isolated from human peripheral blood reticulocytes, was transcribed into complementary DNA by use of the RNA-dependent DNA polymerase of avian myeloblastosis virus. The complementary DNA was then transcribed into (32)P-labeled complementary RNA by E. coli RNA polymerase in the presence of alpha-(32)P-labeled ribonucleoside triphosphates. The fingerprint pattern obtained from ribonuclease T1 digests of human globin complementary RNA was specific and reproducible. Different patterns were obtained from digests of duck, mouse, and rabbit globin complementary RNA. The fingerprint patterns obtained from digests of purified natural human 10S globin messenger RNA, labeled in vitro with (125)I or with [gamma-(32)P]ATP and polynucleotide kinase, were similar to that of the complementary RNA but contained some additional oligonucleotides. Sufficient nucleotide sequence information has been obtained from about 50% of the intermediate sized oligonucleotides (8-14 base residues long), to make possible examination of correspondence between these nucleotide sequences and globin amino-acid sequences. Approximately 70% of these oligonucleotide sequences can be matched to unique amino-acid sequences in the alpha- or beta-globin chains. The other 30% do not match known amino-acid sequences and presumably correspond to untranslated portions of the mRNA; some of these sequences, however, can be matched to amino-acid sequence in the abnormally long segment of the alpha chain of hemoglobin Constant Spring, which is thought to result from a chain-termination mutation.


Stimulation of angiotensinogen release by raised blood angiotensin concentration in the dog.


Proceedings: The effect of thymectomy and oestrogen administration on the secondary antibody response of Swiss mice.


Neoantigens on spontaneous and carcinogen-induced rat tumors defined by in vitro lymphocytotoxicity assays.


Evidence for virus-specific transplantation antigen in cells of lymphoid neoplasms induced by papovavirus SV40.


A comparative ultrastructural study of hepatocyte nucleolar structures observed in physiological and pathological conditions.


Rat alpha1F. XI. Immunological control of cell proliferation: increased growth rate and alpha1F production by Morris hepatoma 5123tc in rats treated with anti-thymocyte serum.


Deoxyribonucleic acid of the crab Cancer pagurus. 3. Intracellular localization of poly d(A-T) of Cancer pagurus by hybridization in situ.


Heterochromatin differentiation in Trillium kamtschaticum by ammoniacal silver reaction.


Radiotransparent electrodes for recording precordial electrocardiographic leads during catheterization.


The effects of the S-protein on intracranial self-stimulation in the rat.


A study of the interaction of bromocresol green with isolated serum globulin fractions.


Effects of repeated heating on human albumin.


The association of lung shadowing with hypersensitivity responses in patients with allergic broncho-pulmonary aspergillosis.


Investigations on the innervation of the human diaphragm.


The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: investigation of their pharmacological properties.


Mastery learning and group study in a dietetics curriculum.


Insulin antibodies in diabetic pregnancy.


Editorial: Incompatible physicians.

Editorial: Incompatible physicians.


Editorial: Representing the Scots.

Editorial: Representing the Scots.


Psychiatry and political dissent.

Psychiatry and political dissent.


Letter: HL-A8 and HL-A12 in coeliac disease.


Letter: A.C.D. and C.P.D. blood preservation.


Influence of anterior hypothalamic heating on the duration of fast wave sleep episodes.


Clinical studies of the evoked response to rapid random flash.


Variability of the human average evoked brain response to visual stimulation: a warning.


A method of evaluation of the effectiveness of dental operatory delivery systems.


Inter-session stability of human alpha rhythm densities.


Semi-automatic, multi-channel Fourier analyser for evoked potential analysis.


Hemispheric asymmetry: frequency analysis of visual and auditory evoked responses to non-verbal stimuli.


Diurnal variation in physiological tremor.


Computer analysis of EEG wakefulness-sleep patterns during learning of novel and familiar sentences.


The effect of caffeine, nitrazepam and cigarette smoking on the contingent negative variation in man.


A complete EEG radio-telemetry equipment.


A peculiar cortical electric response after low intensity visual stimulation in the dark adapted rat.


Increased permeability of the rat mast cell membrane to sodium and potassium caused by extracellular ATP and its relationship to histamine release.


Morphological changes induced by ATP on rat mast cells and their relationship to histamine release.


Reciprocal tachycardia using a left-sided bypass (type A) in patients with type B Wolff-Parkinson-White.


Treatment of non-Hodgkin's lymphoma. Standard treatment.


Yeast- and mycelial-phase antigens of Blastomyces dermatitidis: comparison using disc gel electrophoresis. The disc gel electrophoretic patterns obtained with skin test-active (mycelial and yeast) antigens of Blastomyces dermatitidis were compared. As would be expected, the blastomycins (mycelial-phase) and the cytoplasmic ultrafiltrates (yeast-phase) were heterogeneous mixtures containing proteins, glycoproteins, lipoproteins, and carbohydrates. The skin test-active cytoplasmic ultrafiltrates and the blastomycins contained glycoproteins that had similar R(f) values which allows the possibility that one or more of these components is responsible for the skin-test reactivity of these antigens. The electrophoretic migration of the alkali-soluble, water-soluble cell wall antigen differed from those of the cytoplasmic antigens and the two blastomycins. Electrophoresis, Sephadex chromatography, and ultrafiltration studies showed that the alkali-soluble, water-soluble cell wall antigen is comprised of lipid, polysaccharide, and protein and has a molecular weight range of 30,000 to 50,000. The increased number and mobility of both the protein and carbohydrate bands after denaturation and electrophoresis of this antigen in sodium dodecyl sulfate indicate that there are several cross-linkages between the polysaccharide and/or protein moieties, possibly via lipid or disulfide bridges.


Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria.


Hyperthyroidism and pregnancy.

Hyperthyroidism and pregnancy.


Treatment of Hodgkin's disease.

Treatment of Hodgkin's disease.


The sex chromosomes of the Chinese hamster: constitutive heterochromatin deficient in repetitive DNA sequences.


Cytology of the pituitary gland of the Indian desert gerbil Meriones hurrianae Jerdon.


Acoustic jaw reflex in man: its relationship to other brain-stem and microreflexes.


Modifications of pulvinar and geniculo-cortical evoked potentials during visual discrimination learning in monkeys.


Pulmonary fibrosis following multiple treatment with bleomycin (NSC-125066) in dogs.


Liver histamine and zinc in guinea pig anaphylaxis.


Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine- and 5-iododeoxyuridine substituted Chinese hamster chromosomes.


Lysosomes of the arterial wall. IV. Cytochemical localization of acid phosphatase and catalase in smooth muscle cells and foam cells from rabbit atheromatous aorta. Cytochemical methods for acid phosphatase and catalase were applied to atheromatous aortas from cholesterol-fed rabbits. Whole tissue, partially digested aortic slices and isolated cells were used for the study. Present in the atheromatous lesions were smooth muscle cells in all stages of foamy transformation, from virtually normal appearing smooth muscle cells to severely altered cells with pronounced lipid accumulation. The results with the acid phosphatase method show that lysosomes increase both in size and in number as the smooth muscle cells become foam cells. In normal appearing smooth muscle cells, acid phosphatase reaction product was found in stacked cisternae of the Golgi apparatus and in small vesicles located in the Golgi region and distributed throughout the cytoplasm. In foam cells, reaction product was found in membrane-limited vacuoles of varying size which typically contained membranous debris or myelin-like figures together with massive lipid deposits. No reaction was seen in "free" cytoplasmic lipid droplets lacking a surrounding membrane. These results confirm and extend previous biochemical findings indicating that, in the cholesterol-fed rabbit, the change from normal smooth muscle cell to foam cell is accompanied by marked physical and chemical changes of the lysosomes, including their progressive overloading with cholesteryl ester. Small diaminobenzidine-positive particles were present in normal smooth muscle cells and in those at all stages of foamy transformation. These particles were more frequent in foam cells, in agreement with the marked increase in catalase activity detected biochemically in these cells.


Fluorescent staining of L cell centromeres and chromocenters with 1-dimethylaminonaphthalene-5-sulfonyl chloride and G-bandings.


The hemolytic uremic syndrome, with positive immunofluorescence studies.


Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs.


Developing an activity program in a welfare hotel.


In vitro characteristics of a myxopapillary ependymoma of the filum terminale maintained in tissue and organ culture systems. Light and electron microscopic observations.


Editorial: DNA polymerase and hepatitis B antigen.


On the diagnosis and treatment of sinoatrial disease with special reference to sinoatrial Wenckebach.


Adrenergic mechanisms and immediate-type allergy.


Localization of muscle spindles in the human Extensor Indicis muscle for biopsy purposes.


Morphological classification of rat incisor ameloblasts.


Intensive intravenous regimen for severe attacks of ulcerative colitis.


Frequency of mycoplasma in fertile and infertile couples.


Editorial: On the rocks.

Editorial: On the rocks.


Editorial: Trachoma.

Editorial: Trachoma.


Editorial: Childproofing the medicines bottle.


Vibrio parahaemolyticus food-poisoning in Britain.


Letter: American Medical Association.

Letter: American Medical Association.


Letter: Phosphoglucose isoenzymes in spermatozoa.


Letter: Small doses of intramuscular insulin in the treatment of diabetic "coma".


Letter: Bowie and Dick test.

Letter: Bowie and Dick test.


Letter: Prostaglandin-F2alpha receptor in human corpora lutea. The luteolytic effects of prostaglandin F2alpha (PGF2a) had been demonstrated in animals, but not in men.  This study presents evidence for the existence of very specific receptors for prostaglandin in the human corpora lutea.  Corpora lutea removed during surgery were suspended in a 0.01M Tris-HCL buffer; the mixture was homogenized and centrifuged at 600 g for 10 minutes, and then at 100,000 g for 60 minutes.  The resulting pellet was resuspended in the Tris-HCL (indomethacin solution).  Aliquots of this suspension were added to labelled PGF2a mixtures.  Incubation mixtures containing unlabelled PGF2a served as controls for nonspecific binding.  Sephadex chromatography was used to separate bound and free PGF2a.  A Scatchard plot from an experiment in which 2 corpora lutea were combined (days 19 and 24 of the menstrual cycle) suggested the existence of 2 population of receptors with different dissociation constants (Kd).  The higher affinity receptor had a Kd of 55 nM; concentration of receptor sites was 0.05 pmol per mg of protein.  The lower-affinity receptor had a Kd of 500 nM and a concentration of binding sites of 0.25 pmol per mg protein.  The presence of PGF2a in human corpora lutea suggests the physiological role of prostaglandins in human luteolysis.  The local synthesis of PGF2a in the ovary is suggested.  Such mechanism makes the human corpus luteum less susceptible to exogenous PGF2a than corporalutea of other species, which are normally supplied with PGF2a from the uterus.  The results also suggest the prostaglandin-mediated luteolytic mechanism in man.  Further research should be done with metabolically more stable prostaglandin analogues which have high affinity for the receptor.


Ida Macalpine.

Ida Macalpine.


Evaluating a self-instructional module in quantity food purchasing.


Relation between benign prostatic hyperplasia and cancer of the prostate. A prospective and retrospective study.


Survival of patients with late ventricular fibrillation after acute myocardial infarction.


Hodgkin's disease mortality among physicians.


Prolonging remission in myeloblastic leukemia by tice-strain bacillus Calmette-Guérin.


Beta-o thalassemia--time for a reappraisal?


Editorial: Tuberculosis of the spine.

Editorial: Tuberculosis of the spine.


Editorial: Who defends the patient?

Editorial: Who defends the patient?


Editorial: Microbial-antigen detection.

Editorial: Microbial-antigen detection.


Editorial: Ballon v. bladder.

Editorial: Ballon v. bladder.


Issues in National Health Insurance in the United States of America.


Clinical effects on drug abuse of a conviction for a drug offence.


Letter: HBAg in breast milk.

Letter: HBAg in breast milk.


Letter: Blood fractions for haemophilia.


Letter: Respiratory filters in clinical practice.


Letter: D.N.C.B. test in hepatitis.

Letter: D.N.C.B. test in hepatitis.


Letter: Cannulation of the radial artery.


Letter: Klebsiella in hospital-acquired infections.


Letter: Ampicillin-resistant Haemophilus influenzae.


Letter: Postoperative gynaecological wound infection.


Letter: Paget's disease as hereditary defect of connective tissue.


Letter: Immune competence in Crohn's disease.


Letter: Haemodialysis in multiple trauma.


Letter: Transfer factor in adult rheumatoid arthritis.


Letter: Serum-gentamicin levels after intravenous bolus injection.


Letter: Adriamycin in acute leukaemia.

Letter: Adriamycin in acute leukaemia.


Letter: Synthetic prostaglandin in gastric ulcer.


Letter: Uterine hypertonus after oral prostaglandin E2. Oral prostaglandin E2 (PGE2) is now widely used in conjunction with amniotomy for induction of labor, especially in the parous patient and the primigravida with a favorable cervix.  It has been highly successful and the oral tablets now on trial seem to have a low incidence of side effects.  The main concern in using a swallowed drink or a tablet was the possible development of uterine hyperstimulation after the longacting dose of uterine stimulant had been given.  However, only a few cases have been reported with a wide variety of regimens of PGE2; thus this complication seems rare except with higher intravenous doses.  The following case is reported wherein severe uterine hypertonus after induction of labor with low-dose oral PGE2 tablets developed.  A 32 year old woman, para 2 had had 2 previous spontaneous vertex deliveries of healthy infants weighing 7 pounds (3.2 kg) and 8 pounds 4 ounces (3.6 kg), after 7 hours and 5 hours of labor.  The pregnancy had been uneventful and induction of labor was carried to term plus 9 days by low amniotomy and oral PGE2.  The cervix was given an inducibility rating of 6.  Within the 1st hour a high baseline intraamniotic pressure was noted (up to 30 mmHg) but this fell spontaneously to under 15 mm.  The 4th hourly dose was omitted since the patient was in very good labor and a rise in baseline pressure to 25 mm had again occurred with 80 mm contractions every 2 minutes.  80 minutes after the 3rd dose the patient began to have increasing abdominal pain and prolonged contractions.  An intraamniotic baseline pressure showed a rise to over 60 mm for periods of 4, 4, 8, and 10 minutes, with only brief falls to 30 mm in between.  The patient was in continuous severe pain unrelieved by 50 mg intravenous pethidine and nursing on her side.  The fetal heart fell progressively from a baseline of 125/minute to 60 just prior to delivery.  The cervical dilatation was only 5 cm with the vertex 1 cm above the ischial spines 20 minutes before delivery.  Labor was clearly progressing rapidly.  When the head had entered the pelvic region, preparations were made to expedite delivery with the ventouse, but full dilatation was reached quickly and delivery was achieved with Haig Ferguson forceps.  A healthy male child weighing 7 pounds, 4 ounces (3.3 kg) was delivered with an Apgar of 5 but he rapidly responded to simple resuscitation with mucus extraction and oxygen.  In spite of the total low dose of PG and the rarity of significant hypertonus reported with PGs, it is clear that the severe hypertonus was due to PG stimulation.  It is also unusual since the condition occurred long after the last PG administration.  In such a severe case, it might be wise to consider a rapid intravenous infusion of ethyl alcohol.


Letter: Measurement of skin blood-pressure.


Letter: B lymphocytes during ageing.

Letter: B lymphocytes during ageing.


Letter: Lysine metabolism in Reye's syndrome.


Letter: Hyponatraemia.

Letter: Hyponatraemia.


Letter: Serum-cholesterol and dietary carbohydrates.


Letter: Pathologists at the crystal ball.


Letter: "Menstrual toxin".

Letter: "Menstrual toxin".


Letter: Tonsillectomy and Hodgkin's disease.


Letter: Variation of stump volume after below-knee amputation.


Letter: Probability of death related to previous army rank.


Letter: Klinefelter's syndrome in a fetus.


Letter: Anti-oestrogens and breast cancer.


Letter: Classification of anti-tumour drugs.


Letter: Maternal smoking and neonatal hyperbilirubinaemia.


Letter: Cerebral intravascular coagulation in diabetic ketocidosis.


Letter: Measuring malnutrition.

Letter: Measuring malnutrition.


Letter: Alpha-fetoprotein in Indian childhood cirrhosis.


Letter: Aetiology of kwashiorkor.

Letter: Aetiology of kwashiorkor.


Letter: Oral contraception and sex ratio.


Letter: Action of cyproterone acetate.

Letter: Action of cyproterone acetate.


Letter: Serotyping Neisseria meningitidis.


Letter: Proguanil and mouth ulcers.

Letter: Proguanil and mouth ulcers.


Rhythmic activity of a group of human motoneurones during voluntary contraction of a muscle.


Systemic lupus erythematosus with signs of retroperitoneal fibrosis.


Structural features of histamine release in rat peritoneal mast cells. A study with toluidine blue.


Letter: Breast cancer at site of implantation of pacemaker generator.


Heparin versus dextran in the prevention of deep-vein thrombosis. A multi-unit coctrolled trial.


Intestinal absorption of 25-hydroxycholecalciferol.


Editorial: Dimethyltryptamine and psychosis.


The general-practice dilemma.

The general-practice dilemma.


Letter: Industrial action by radiographers.


Keratin bodies. A clue in the cytological detection of endometrial adenoacanthoma. Report of two cases.


Letter: D.N.A. binding in rheumatoid arthritis.


Letter: Allopurinol in leukaemias and lymphomas.


Letter: Positive feedback from a Royal College.


Letter: Plasma-calcitonin and non-thyroid tumours.


Letter: Abdominal pain after intravenous benzylpenicillin.


Letter: Origin of Hodgkin's cell.

Letter: Origin of Hodgkin's cell.


Letter: Catalin, quinones, and cataract.


Letter: Vaginal smears after total hysterectomy.


Letter: Rifampicin and immunosuppression.


Letter: Specificity of N.B.T. test.

Letter: Specificity of N.B.T. test.


Letter: Maldescended testes.

Letter: Maldescended testes.


Anna Josephine Mayr-Harting.

Anna Josephine Mayr-Harting.


Gordon Chester Kennedy.

Gordon Chester Kennedy.


Biosyntheses of new bleomycins.

Biosyntheses of new bleomycins.


Physical growth and development, neurological maturation, and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. II. PTC taste sensitivity and neurological maturation.


Bronchial asthma produced by paranasal sinusitis.


Hypersensitivity to intravenous morphine sulfate.


Restoration of specific immunological virginity.


Stimulatory capacity of human T and B lymphocytes in the mixed leukocyte culture.


Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice.


Kynurenine formamidase. Purification and characterization of the adult chicken liver enzyme and immunochemical analyses of the enzyme of developing chicks.


Faculty time expenditures for an audiovisual periodontology course.


Serotypes of trachoma agent isolated in the Gambia: with an observation on the relation between serotype and morphology. Of 60 TRIC agents isolated from Gambian children with trachoma, 25 were serotype 1 and the remainder type 2. There was a pronounced difference in the proportions of these types in the two villages studied. In the village with a predominance of type 2 strains, TRIC agents remained confined to 2 adjacent compounds over a 14 month observation period. All 19 type 1 strains examined were characterized by the appearance in yolk sac smears of compact aggregates of elementary bodies; such aggregates were seen in only 2 of 35 type 2 strains, and may reflect a chemical difference in the surface of the elementary bodies or in a substance elaborated during their replication.


Down and Klinefelter syndromes (48, XXY, G+) in a young man. Cytogenetic, endocrine, and testicular steroidogenesis studies.


Experimental allergic encephalomyelitis in triethyltin sulfate-treated brown Norwegian and Lewis rats.


Intercellular junctions of the tracheal epithelium in guinea pigs.


Morphometric analysis of sarcomas with different karyotypes.


Alpha-1-fetoprotein and alcoholic hepatitis.


A hormonally influenced human serum globulin: elevation of Xh by estrogen.


The cold-insoluble globulin of plasma and its relationship to factor VIII.


A simplified platelet factor 3 (PF-3) assay for the rapid detection of platelet isoantibodies and an antiplatelet factor in ATP and SLE.


Fiber types in the human brachial biceps muscle.


Human immune response to active immunization with Rauscher leukemia virus. I. Cell-mediated and cell-associated immunity.


Characteristics of an established cell line of retinoblastoma.


Detection of Mason-Pfizer virus infection with human KC cells carrying Rous virus genome.


Plaque assay for the Mason-Pfizer monkey virus.


Transplantation isoantigenicity of a rat sarcoma and its spontaneous metastases.


Presence of A-type and absence of C-type virus particles in a chemically induced guinea pig hepatoma.


Application of radioimmunoassay to pharmacology.


Late recurrence of testicular tumor.

Late recurrence of testicular tumor.


The effects of various manipulations on serum phosphatase levels in benign disease.


Value of radiotherapy for adenocarcinoma of the prostate simulating primary rectal carcinoma.


Association of Reye's syndrome with viral infection.


Modulation, by food, of hormonal system regulating rat pancreatic secretion.


Diagnosis of insulinomas by suppression tests.


Risk of transfusing blood containing antibody to hepatitis-B surface antigen.


Seasonal occurrence of complex ventricular septal defect.


Effect of meals on rifampicin absorption.


Peak-flow meter versus peak-flow gauge.

Peak-flow meter versus peak-flow gauge.


Editorial: What price the N.H.S.?

Editorial: What price the N.H.S.?


Editorial: Renal-artery stenosis and renal failure.


Editorial: Gram-negative infective polyarthritis.


Editorial: Reorganization on Humberside.


Editorial: Colonic explosions.

Editorial: Colonic explosions.


Multi-infarct dementia. A cause of mental deterioration in the elderly.


Medical work and social power.

Medical work and social power.


Letter: Pathogenesis and natural history of porphyria cutanea tarda.


Letter: Industrial action in the N.H.S.

Letter: Industrial action in the N.H.S.


Letter: Inequality and the health service.


Letter: Domiciliary physiotherapy service.


Letter: Pathologists, thechnologists, crystal balls, or vipers in the bosom.


Letter: Role of the community physician.


Letter: Vitamins in the elderly.

Letter: Vitamins in the elderly.


Letter: Lack of antigenic correlation between chicken brain and thymus.


Letter: Treatment of paracetamol overdosage.


Letter: Subpopulations of B lymphocytes in human tonsils and peripheral blood.


Letter: Mixed receptors.

Letter: Mixed receptors.


Letter: T and B lymphocytes.

Letter: T and B lymphocytes.


Letter: Depression of lymphocyte transformation in women taking oral contraceptives.


Letter: Quantitative bone scanning.

Letter: Quantitative bone scanning.


Letter: Teaching biochemistry to medicals.


Letter: Maternal alcoholism and intellectual development of offspring.


Letter: Peptic ulcer in childhood.

Letter: Peptic ulcer in childhood.


Letter: Hepatitis-B antigen and tobacco plants.


Letter: Milk antibodies and myocardial infarction.


Letter: Fibrinolytic activity and treatment of diabetes.


Letter: Fate of 125I-labelled fibrinogen.


Letter: Increased warfarin requirement during mercaptopurine therapy: a new drug interaction.


Letter: Varieties of von Willebrand's disease.


Letter: Kwashiorkor and tuberculosis.

Letter: Kwashiorkor and tuberculosis.


Letter: Mechanism of the anti-aggregating effect of aspirin on human platelets.


Letter: Hypochromotrichia in malnutrition.


Editorial: Dilating oesophageal strictures.


Letter: Cannulation of radial artery.

Letter: Cannulation of radial artery.


Letter: Limulus assay for gram-negative endotoxin.


Letter: Depression of D.N.A.-polymerase activity by lithium.


Letter: The 47 XXY karyotype.

Letter: The 47 XXY karyotype.


Letter: Dangers in nuclear-sexing the fetus.


Letter: 8-21 translocation and missing sex chromosomes in acute leukaemia.


Letter: Follow-up of urinary-tract infection in children.


Letter: Dip test for bacteriuria.

Letter: Dip test for bacteriuria.


Letter: Treatment by vertebral manipulation.


Letter: Acute arthralgia following high-dose intravenous methylprednisolone therapy.


Letter: Diagnosis of superior-vena-cave obstruction.


Letter: Hypertrophy of extensor digitorum brevis in limb-girdle muscular dystrophy.


Letter: Stimulation of the spinal cord in motor-neurone disease.


Letter: Prolactin and migraine.

Letter: Prolactin and migraine.


Letter: Dietary carbohydrate and serum-cholesterol.


Letter: Medical nemesis.

Letter: Medical nemesis.


Letter: Fusidic acid in psoriasis.

Letter: Fusidic acid in psoriasis.


Charles Edward Lumsden.

Charles Edward Lumsden.


Letter: Rifampicin and drug metabolism.

Letter: Rifampicin and drug metabolism.


Victor Ewings Negus.

Victor Ewings Negus.


Letter: Lipophilic paraproteins.

Letter: Lipophilic paraproteins.


Immunologic diagnosis of human cancers.

Immunologic diagnosis of human cancers.


Preliminary results of a computer logic program for the operative management of colon cancer.


Antigenicity of fetal and adult cerebral tissue of man.


Gametocytes, sporozoites and liver schizonts.


The nature of ventricular ectopic beats in chronic ischaemic heart disease.


Effect of vitamin A alcohol on the surface coat and charges of L1210 leukemic cells.


Mammary carcinogenesis in foster-nursed X-Gf mice.


Phase II study of concurrent methotrexate and bleomycin chemotherapy.


5-azacytidine-modified patterns of uridine kinase activities in normal and neoplastic tissues.


Evidence in favor of the existence of human breast cancer virus.


Responses of cycling and noncycling cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and to bleomycin.


Controlled clinical trial of four short-course (6-month) regimens of chemotherapy for treatment of pulmonary tuberculosis. Third report. East African-British Medical Research Councils.


A clinical trial of the treatment of haemorrhoids by operation and the Lord procedure.


Effect of different doses of chenodeoxycholic acid on bile-lipid composition and on frequency of side-effects in patients with gallstones.


Editorial: Bone necrosis in divers.

Editorial: Bone necrosis in divers.


Editorial: Iatrogenic hip disease.

Editorial: Iatrogenic hip disease.


Editorial: Laparotomy-the final court of appeal?


Editorial: Deviance in the classroom.

Editorial: Deviance in the classroom.


Editorial: Health policy and medical education.


Subnormality and its relation to psychiatry.


Letter: Protein requirement.

Letter: Protein requirement.


Ocular vaccinia.

Ocular vaccinia.


Letter: Hunger in Mauritania.

Letter: Hunger in Mauritania.


Letter: Thermosensitive transfer factors in chloramphenicol-resistant strains of Salmonella typhi.


Letter: Imperialism: chloramphenicol.

Letter: Imperialism: chloramphenicol.


Letter: Geriatrics.

Letter: Geriatrics.


Letter: Private practice.

Letter: Private practice.


Letter: Industrial action in the N.H.S.

Letter: Industrial action in the N.H.S.


Letter: Co-trimoxazole and the blood.

Letter: Co-trimoxazole and the blood.


Letter: Peptic ulceration and D-penicillamine.


Letter: Subnormality at the crossroads.

Letter: Subnormality at the crossroads.


Letter: Rejection.

Letter: Rejection.


Letter: General-practice dilemma.

Letter: General-practice dilemma.


Letter: Bleeding and perioperative heparin.


Letter: Subcutaneous heparin and postoperative deep venous thrombosis.


Letter: Childproofing the medicines bottle.


Letter: HL-A and disease.

Letter: HL-A and disease.


Letter: HL-A and idiopathic Addison's disease.


Letter: Claims for a diathermy machine.

Letter: Claims for a diathermy machine.


Letter: Academics in the community.

Letter: Academics in the community.


Letter: Bubbles show air movement in operating-theatres.


Letter: National health insurance in the U.S.A.


Letter: Angio-immunoblastic lymphadenopathy with dysproteinaemia.


Letter: Suppression of delayed hypersensitivity in Graves' disease.


Letter: Macronumbers of microorganisms.

Letter: Macronumbers of microorganisms.


Letter: Bone-marrow preparations in chromosome studies.


Letter: Methods of B.C.G. vaccination.

Letter: Methods of B.C.G. vaccination.


Letter: Benign prostatic hyperplasia.

Letter: Benign prostatic hyperplasia.


Letter: Mortality in agranulocytosis.

Letter: Mortality in agranulocytosis.


Letter: Serum-complement levels in haemolytic-uraemic syndrome.


Letter: Impaired neutrophil phagocytosis.


Letter: Antibiotics and neonatal hyperbilirubinaemia.


Letter: Familial aggregation in nasopharyngeal carcinoma.


Letter: HL-A typing and kidney transplantation.


Letter: T and B lymphocytes in liver.

Letter: T and B lymphocytes in liver.


Letter: Diet for diabetics.

Letter: Diet for diabetics.


Letter: A shower of aortic aneurysms.

Letter: A shower of aortic aneurysms.


Letter: Danger of varicella to immunosuppressed patients.


Letter: Coagulase-negative Staphylococci in the urinary tract.


Letter: Self and not-self.

Letter: Self and not-self.


Letter: Another blood product.

Letter: Another blood product.


Letter: Colonies of Trichomonas vaginalis on Mycoplasma medium.


Letter: Blood fractions for haemophilia.


Selective immunosuppression using antigens and antibodies as pharmacologic agents.


Drug-induced autoimmune disease.

Drug-induced autoimmune disease.


A review of development of adipose cellularity in man and animals.


Recent results of two-stage surgical treatment of large ventricular septal defect.


Atrial septectomy in patients with D-transposition of the great arteries, ventricular septal defect, and severe pulmonary vascular obstructive disease.


Transventricular mitral valvulotomy. Analysis of factors influencing operative and late results.


Proceedings: The identification of two platelet specific release products.


The diagnosis of thyrotoxicosis.

The diagnosis of thyrotoxicosis.


The interaction of dihydrotestosterone and oestradiol-17beta with macromolecules in human hyperplastic prostate tissue.


Lability of human decidual cells. In vivo effects of hypertonic saline.


Reply to letter. The possibility of diagnosing lower genital tract infections with Corynebacterium vaginale by means of wet mounts and stained smears.


Thrombin stimulated release of platelet microfibrils.


Amniotic fluid beta-2 microglobulin concentration--an index of gestational age.


Antenatal fetal sex determination from maternal blood during early pregnancy.


The ossification process of the developing antler in the white-tailed deer (Odocoileus virginianus).


Mechanism of histamine release from guinea-pig lung by soluble immune complexes. II. Role of anaphylatoxin.


Histological preparation of bone to study ingrowth into implanted materials.


Measurement of growth and resorption of bone in the seventh caudal vertebra of the rat.


Histochemical studies on calcified tissues. I. Amino acid histochemistry of foetal calf and human enamel matrix.


Reverse transcriptase in normal rhesus monkey placenta. Particles with the morphology of type C virus have been identified from primate placentas by electron microscopy. A reverse transcriptase (RNA-dependent DNA polymerase) was isolated and purified from microsomal pellets of two fresh placentas of rhesus monkeys in the early stages of gestation. This enzyme was biochemically similar yet immunologically distinct from the reverse transcriptases of known tumorigenic type C RNA viruses isolated from primates, but was immunologically related to a reverse transcriptase isolated from a type C virus obtained from normal baboon placenta. These particles may represent endogenous viruses and may function in the transfer of genetic information during embryogenesis.


An electron microscopic study of some protein fractions from bovine erythrocyte ghosts.


Non-specific binding of proteins by substituted agaroses.


Retinoblastoma at Groote Schuur Hospital 1952-1972.


Laboratory problems in the diagnosis of trachoma.


Malignant melanoma of the choroid a review of the histopathology of 100 cases.


Nutritional and metabolic aspects of heredopathia atactica polyneuritiformis (Refsum's syndrome).


Estradiol-17beta-hydroxysteroid dehydrogenase activity in preimplantation rat embryos.


Treatment of malignant esophageal obstruction by endoesophageal intubation.


Etiologic factors in ulcerative colitis: birth, death and symbolic equivalents.


S-tropic murine type-C viruses: frequency of isolation from continuous cell lines, leukemia virus preparations and normal spleens.


Detection in human melanoma cell lines of particles with some properties in common with RNA tumour viruses.


Genetic control of susceptibility to 3-methylcholanthrene-induced subcutaneous sarcomas.


Proceedings: Anaphylactic release of prostaglandins, slow-reacting substance, and histamine, and its modification by sympathomimetics.


Proceedings: Temporal relationship between rat liver histone acetylation and nuclear RNA polymerase activities after alpha-hexachlorcyclohexan application.


Proceedings: The influence of glucocorticoids on the stimulability of adenyl-cyclase and the anaphylactic histamine release in the guinea pig lung in vitro.


Proceedings: Control by feeding habits of the induction of hepatic DNA synthesis by alpha-hexachlorocyclohexane.


Proceedings: Arterial and venous blood histamine levels after I.V. administration of histamine liberators in the dog in vivo.


Proceedings: Influence of oxymetazoline and phentolamine on noradrenaline (NA) release caused by electrical stimulation, potassium, tyramine and dimethylphenylpiperazine (DMPP).


Alpha 1-antitrypsin deficiency associated with PZ and MP phenotypes. Clinical and laboratory correlations.


Effect of G-banding techniques on the ultrastructure of human chromosomes.


Sjögren-Larsson syndrome. Oligophrenia--ichthyosis--di-tetraplegia.


Strongly fluorescent chromosome bands in metaphase and interphase.


Direct Giemsa-banding pattern analysis of human chromosomes by means of a television microdensitometer: the Quantimet 720D.


Identification of a large submetacentric X chromosome as pericentric inversion of an isochromosome of the long arm.


45,X-45,X, ace(?Yp)plus-46,X,r(Y) in a phenotypically normal newborn male.


Use of sodium hydroxide in the preparation of epidermal peels from certain coniferous leaves rich in resins and tannins.


Collecting human chromosomes for whole-mount electron microscopy.


A simple assay procedure for mixtures of hematoxylin and hematein.


A method for obtaining longitudinal cryostat sections of living muscle without contraction artifacts.


A method for the selective removal of deoxyribonucleic acid from tissue sections.


A simple silver solution for staining reticulin.


Oriented embedding of single-cell organisms.


Toluidine blue staining of coccidia in cultured animal cells.


Some observations on the demonstration of calcium oxalate in tissue sections.


Autoclaving as an aid in the clearing of plant specimens.


Sudan IV staining as a means of visualizing cleavage patterns in telolecithal eggs.


Serial sectioning of Epon-embedded material for autoradiography.


Thin-layer chromatography of lipids in adenovirus-treated human erythrocytes.


Identification of nonfermentative gram-negative rods in clinical material.


Determination of plasma prothrombin with a reaction rate analyzer using a synthetic substrate.


Antibodies with a gliotoxic effect in sera from rabbits injected with peptide 1-43 of the bovine encephalitogenic protein.


Rotation cultures from different regions of embryonic chick brain. I. Biochemical and morphological characteristics.


Effect of malnutrition on experimental allergic encephalomyelitis.


Lymphocyte sensitization to basic protein of brain in multiple sclerosis and other neurological diseases. The number of lymphocytes in the blood sensitized to encephalitogenic factor (EF) is less in multiple sclerosis than it is in general paralysis of the insane. The number appears related to the extent of parenchymatous destruction. The study offers no support for the view that lymphocyte sensitization to EF is of pathogenetic significance in multiple sclerosis.


Episodic encephalopathy associated with thyroid disorders. Two patients with a thyroid disorder and an associated episodic encephalopathy are reported. The relationship between Hashimoto's thyroiditis, myxoedema, and neurological disease is considered, and the evidence for such disorders being due either to an underlying autoimmune process or that the encephalopathy is a direct result of the thyroid disorder is discussed.


Comparative chromosome studies in Pinnipedia.


Haploid meiosis as a regular phenomenon in the life cycle of Ulva mutabilis.


Prematurely condensed chromosomes of the Indian muntjac: a model system for the analysis of chromosome condensation and banding.


Dicentric human X chromosomes.

Dicentric human X chromosomes.


Chromosome banding pattern in a polymorphic population of Sorex araneus from northeastern Finland.


Heterogeneity of Ph1 in chronic myeloid leukaemia.


Localisation of repetitive DNA in mouse cells by in situ hybridization and dye binding techniques.


Vacuolated villous epithelium of the small intestine of young pigs.


Intracellular growth of an obligatory parasite mycobacterium leprae. Host bacterial interactions.


Autoradiographic localization of intracellular alpha-foetoprotein in primary liver cancer in man.


[Comparative studies on the histochemical behavior of amyloid, fibrinoid and hyalin deposits in blood vessel walls in mammals and birds. II. Carbohydrates].


A comparative morphological study of the developing node-paranode region in lumbar spinal roots. II. Light microscopy after osmiumtetroxide-alpha-naphthylamine (OTAN)-staining.


Changes in the nervous system and musculature of old rats.


Indirect Wallerian degeneration in intramedullary root fibers of the kitten hypoglossal nerve light and electron microscopical observations on silver impregnated sections.


Direct Wallerian degeneration in intramedullary root fibres of the kitten hypoglossal nerve light and electron microscopical observations on silver impregnated sections.


Alpha-fetoprotein as a marker of embryo-specific differentiations in normal and tumor tissues.


Alpha-fetoprotein: immunochemical purification and chemical properties. Expression in normal state and in malignant and non-malignant liver disease.


Comparison of spectrophotometric and gas-liquid chromatographic measurements of serum diphenylhydantoin concentrations in epileptic out-patients.


Phenytoin and folate deficiency: failure to show dose dependency.


Improved techniques for staining and enumerating focus formation in viral infectivity assays. Improved techniques consisting of glutaraldehyde fixation, Giemsa staining, and colony counter enumeration of foci in viral infectivity assays were compared to microscope scanning and lantern slide projection methods. These techniques broadened the scope of application to potentially hazardous viruses and increased the efficiency of assaying.


The effect of cortisol on the phosphorylation of rat liver nuclear acidic proteins and the role of these proteins in biosynthesis of nuclear RNA.


Influence of cardiotonic and cardioplegic agents on the heat production of the heart.


Effect of age and strain on uptake of alpha-amino-isobutyrate.


Methods for determining the fraction of pulmonary surfactant lipid removed from the lung of beagle dogs by lavage.


The kallikrein-kinin system in normal and glomerulonephritic rats.


Glutamine-alpha-keto acid transaminase: partial purification and some properties of the enzyme from brain tissue.


Activation of vestibular neurons during optokinetic nystagmus.


Effect of angiotensin on renal function and intra-renal circulation.


Release by isolated dog kidney of a natriuretic material following saline loading.


Electrical noise and membrane transport processes.


Interpretation of indicator-dilution curves as a local density random walk.


Reliability of radioactive microspheres in regional blood flow measurements.


Participation of baroreceptor reflexes in the perfused dog hind leg during electric stimulation of the hypothalamus.


Effects of adrenalectomy and of neonatal sympathectomy in normotensive, renal hypertensive and spontaneously hypertensive rats.


The relation between end-diastolic volume and source impedance of the left ventricle.


Cross talk between right and left ventricle during the neonatal period.


Correlation between electrophysiologic recordings and morphologic findings in the rabbit atrioventricular node.


Assessment of myocardial contractility from intraventricular pressure recordings.


Ion barriers in muscle fibres.

Ion barriers in muscle fibres.


Persistence of an aldosterone influence on active sodium transport upon exposure of frog skin to ouabain.


Quantitative studies of EEG development in the cerebral hemispheres of the chick embryo.


Differentiation of foetal nervous tissue in tissue culture: morphology, electrophysiology and the effect of nerve growth factor.


Histofluorimetric studies on 5-hydroxytryptamine in the pineal gland of the rat.


Effect of free fatty acids on hepatic adenine nucleotide content and oxidative metabolism.


Radioiodinated insulin fixation to a marine alga: Acetabularia mediterranea.


Influence of saccadic eye movements on area 18 neurons in the cat.


Interocular transfer, ocular dominance and "opposing habit" learning in the rabbit.


The pressure-volume-flow relationship of the lung in healthy and ill neonates.


Determination of O2-consumption, CO2-production and end-expiratory O2-and CO2-pressure in conscious dogs.


Facilitated diffusion: the case of CO.

Facilitated diffusion: the case of CO.


The influence of changing physical load on aortic bloodflow.


Influence of muscular exercise on the rates of uptake and oxidation of infused ketone bodies in normal man.


The influence of an intensive period of training on a number of hematological parameters in male and female top athletes.


Neuronal firing in experimental hypercholesterolemia in rabbits.


Some psycho-physical experiments into the vertical dimension of occlusion of edentulous subjects.


Morphologic aspects of the arterial wall in spontaneously hypertensive rats (SHR).


Determination of the extracellular fluid volume with ferrocyanide as indicator.


Reflex regulation of blood pressure and peripheral vascular tone during muscular contraction in the dog.


Influence of heart rate on regional myocardial blood flow measured with radioactive microspheres in anaesthetized dogs.


Effect of autoregulation on the intracortical distribution of renal blood flow.


Cerebral blood flow measurements with 133 xenon during experimental metabolic alkalosis in the cat.


The measurement of cerebral blood flow in the rat with radioactive microspheres.


Influence of PCO2 on amino acids in the brain of the rat.


The primate globus pallidus: a Golgi and electron microscopic study.


Quantitative determination of the alphafetoprotein (AFP).


The primate substantia nigra: a Golgi and electron microscopic study.


Serum gamma-globulins and hepatitis-associated antigen in blood donors, chronic liver disease and primary hepatoma.


Proceedings: A simple identification of osteoid matrix in decalcified bone.


Aggression and violence in children.

Aggression and violence in children.


Cell wall protrusions induced by cauliflower mosaic virus in Chinese cabbage leaves: a cytochemical and autoradiographic study.


Bleomycin, an inhibitor of vaccinia virus replication.


A proposed nomenclature for the virion proteins of oncogenic RNA viruses.


An epoxy resin embedding technique for large objects.


Elastin V: syntheses, characterization, and staining properties of amidol black I.


Combined enzymatic reaction for nervous and muscular tissues.


A fluorescent brightener used for pollen tube identification in vivo.


Basic Fuchsin-ferric chloride: a simplification of Weigert's resorcin-fuchsin stain for elastic fibres.


Complete staining of neuromuscular innervation with bromoindigo and silver.


Microwave irradiation as a generator of heat for histological fixation.


Comparison of various oxidants for alum hematoxylin.


A rapid method for in situ staining of prostatic and other tissue culture cells.


A rapid thin-layer chromatographic system for Romanowsky blood stains.


A modified toluidine blue staining method for nucleoli of ascites tumor cells.


Distribution and configuration of surface myoneural junctions in the frog sartorius muscle.


Factors affecting the conversion of cross-reinnervated skeletal muscles.


Identification of two populations of lymphocytes in rats and mice by routine transmission electron microscopy.


Primary liver cancer, alpha1 fetoprotein and hepatitis B antigen in Papua New Guinea.


Pentobarbital-induced configurational changes at the synapse.


Long term synaptic reorganization in rat fascia dentata deafferented at adolescent and adult stages: observations with the Timm method.


Some serologic aspects of the immune response in the Atlantic bottle-nosed porpoise.


Progestogens as contraceptives.

Progestogens as contraceptives.


Proceedings: Dynamics of transmissional ultrastructures in sympathetic neurones of the rat.


Proceedings: The effect of electric stimulation on the axoplasmic transport of newly synthetized neuronal proteins.


Proceedings: Some aspects of the release of the adrenergic transmitter.


Proceedings: Pharmacology of the adrenergic mechanism.


Dissociation between the chronotropic and inotropic actions of glucagon.


Development and control of intestinal and hepatic fructokinase.


Intraluminal latex injection: an aid to the histological identification of renal tubules.


The effect of fetuin and of spleen extract on hematopoietic precursors and on differentiated hematopoietic cells in irradiated mice.


Detection of sialic acid containing compounds and the behaviour of gangliosides in polyacrylamide disc electrophoresis.


Some quantitative aspects of the disc electrophoresis of ovalbumin using amido black 10B stain.


Resolubilization of certain apoprotein components of human plasma high density lipoproteins in TCA-fixed polyacrylamide gels during destaining in acetic acid solutions.


Comparison of the methylation of estradiol-17 beta and of estradiol-17 alpha by dimethyl sulfate.


Assistance for the partially sighted child.


The thyroid gland morphology of cats subjected to hunger and thirst.


Myelinated nerves of the rat iris.

Myelinated nerves of the rat iris.


Stimulation of glucose metabolism in rat mast cells by antigen, dextran and compound 48-80, used as histamine releasing agents.


A method for the rapid elution of proteins from "mashed gel" after starch gel electrophoresis.


A theory of precipitation and agglutination reactions in immunological systems.


The relationship between cell viability and changes in mitochondrial ultrastructure, cellular ATP, ion and water content following injury of Ehrlich ascites tumor cells.


Number of nuclei in isolated myocardial cells of pigs.


Changes in the nuclear structure during thyroid carcinogenesis in rats. An image analysis study.


Hemoglobin Siam (alpha 2 15 arg beta 2): a new alpha-chain variant.


Trisomy of the short arm of chromosome 17.


Studies on the polymorphism of the soluble glutamic-pyruvic-transaminase in the population of Northern Bavaria (Germany).


Case study of first course in teaching skills and methods for university medical staff.


Self-instruction in general pathology by means of tape slide presentations.


Review: The health care team.

Review: The health care team.


Photoallergy: a critical survey.

Photoallergy: a critical survey.


Comparison of methods to detect significant bacteriuria.


A histological and histochemical study of the cotyledons of Phaseolus vulgaris L. during germination.


Cataract extraction.

Cataract extraction.


RNA-directed DNA polymerase--properties and functions in oncogenic RNA viruses and cells.


Massive fibroid in the uterus.

Massive fibroid in the uterus.


Nursing care of the elderly lower-limb amputee.


Nursing care study. Above-knee amputation.


Nursing care after primary excision.

Nursing care after primary excision.


Spinal cord trauma. Experimental and clinical developments.


Dynamic radioisotope study with a gamma camera-VTR system-RI angiography and CBF study in neurosurgical practice.


Evoked cortical responses following stimulation of the thalamic VL nucleus in man.


Growth control and adenosine 3':5'-cyclic monophosphate levels in clonal cells of rat glioma.


Morphological and functional properties of pituitary adenomas in culture.


Subtemporal transtentorial approach for large cerebello-pontine angle meningioma.


Statistical analysis of chronic subdural hematoma in 309 adult cases.


Chronic subdural hematoma in the aged.

Chronic subdural hematoma in the aged.


A case revealed prolonged cerebral vasospasm after evacuation of intracerebral hematoma.


A state health education resource center.


Services for the family. 2.

Services for the family. 2.


Eye enucleation.

Eye enucleation.


Better techniques for bagging stomas. 2. Colostomies.


Scoliosis: affectionate yet firm postoperative nursing care. Nursing grand rounds.


Chiasma distribution at diakinesis in the normal human male.


Chromosome preparation by air drying at low temperature and Giemsa banding procedures.


Cytological studies of the genus Rosa with special reference to the section Caninae.


Repetitive DNA and constitutive heterochromatin in the chromosomes of guinea pig.


Pericentric inversion Y in a population of newborn boys.


C-banded male meiotic chromosomes of Acheta domesticus.


How actinomycin binds to DNA.

How actinomycin binds to DNA.


Carriers and specificity in membranes. II. Characterization of carriers. Properties of ion-specific carriers.


Binding studies of boron hydride derivatives to proteins for neutron capture therapy.


Protein-binding polyhedral boranes. 1.

Protein-binding polyhedral boranes. 1.


The ultrastructure of plasma lipoproteins in lecithin:cholesterol acyltransferase deficiency.


Effect of lysophosphatidyl choline on interaction between phosphatidyl choline and activator protein (apolipoprotein A-I) of lecithin:cholesterol acyltransferase.


Traffic pollution.

Traffic pollution.


Carcinogenic air pollutants in the exhaust from a European car operating on various fuels.


Growing points in leprosy research. 4. Recent advances in the chemotherapy of leprosy.


Surgical management of hyperthyroidism: current indications and results.


T3 toxicosis.

T3 toxicosis.


Absence of B- and T-cell markers on acute lymphoblastic leukaemic cells and persistence of the T-cell marker on mitogen-transformed T-lymphocytes.


Malignant disease of the kidney. An appraisal of diagnosis and management. The diverse systemic effects associated with malignant renal tumours are described. It is emphasized that their recognition is essential for the early diagnosis of the tumour and that many of these effects may be overlooked unless the clinician is alert to their significance. Many of these early diagnostic clues also have a prognostic value.Although the basic management of a patient with a renal tumour continues to be a nephrectomy, the importance of tumour staging in relation to radical surgery is emphasized. Adjuvant therapy by radiotherapy, drugs, or immunotherapy is described and evaluated.


Inhibition of allergic reactions by a novel phenanthroline ICI 74,917.


Restricted clonal response to DNP in adult offspring of immunized mice: a maternal effect.


Allotypic markers on Fab fragments of mouse immunoglobulins.


The use of protein-substituted nylon catheters for selective immunoadsorption in vivo.


Isolation of mouse thymus-derived lymphocyte specific surface antigens.


Immunologic reactions to haptens on autologous carriers. II. Induction of hapten-specific tolerance and correlations between antibody response and antigen-driven cell proliferation in vitro.


Immunologic reactions to haptens on autologous carriers. 3. Cell separation at the antigen-specific in vitro DNA synthetic response level.


Effect of carrier priming on the distribution of anti-hapten antibodies between IgG1 and IgG2 isotypes in the hyperimmune guinea pig.


Tumor-specific and allospecific immunogenicity of soluble extracts from chemically induced murine sarcomas.


Recurrent experimental allergic encephalomyelitis in the Lewis rat.


Letter: Serologic code models with respect to the action of allogeneic anti-theta and xenogeneic anti-mouse or rat brain sera on thymocytes and brain tissue.


Double-blind trial comparing two dosage schedules of beclomethasone dipropionate aerosol in the treatment of chronic bronchial asthma. Preliminary report of the Brompton Hospital-Medical Research Council Collaborative Trial.


Body-fluid volume in low-renin hypertension.


Sodium and the renin-angiotensin system in essential hypertension and mineralocorticoid excess.


Reproductive and endocrine function after surgical treatment of bilateral crytorchidism.


Infections in iron deficiency and other types of anaemia in the tropics.


Defect of renal tubular acidification with antibody to loop of Henle.


Hyposplenism in ulcerative colitis.

Hyposplenism in ulcerative colitis.


Renal abnormality of essential hypertension.


Editorial: The right to know.

Editorial: The right to know.


Editorial: Iron and resistance to infection.


Editorial: Mumps vaccine.

Editorial: Mumps vaccine.


Editorial: Concern for quality.

Editorial: Concern for quality.


Editorial: Transoceanic schizophrenia.

Editorial: Transoceanic schizophrenia.


Vaccination in the control of influenza. Interim report to the Director of the Public Health Laboratory Service on a Collaborative Study with the Post Office.


Serum-alpha 1-fetoprotein in hepatocellular carcinoma.


Planning in district management. Use of a teaching game.


Letter: The bran hypothesis.

Letter: The bran hypothesis.


Letter: Yellow fat and visceral malignancy.


Letter: Recurrent varicella-like illness in a child with leukaemia.


Letter: Alcoholism among doctors.

Letter: Alcoholism among doctors.


Letter: HBAg carrier state in an infant delivered by caesarean section.


Letter: Serum hepatitis in late pregnancy.


Letter: Cross-reaction of antibodies to human lactoferrin with HBAg.


Letter: Detection of HBAg by passive haemagglutination.


Letter: Prevention of post-transfusion hepatitis.


Letter: False-positive results in antenatal diagnosis of neural-tube disorders.


Letter: Rapid diagnosis of Down's syndrome.


Letter: Transcervical fetoscopy.

Letter: Transcervical fetoscopy.


Letter: Klinefelter's syndrome in a fetus.


Letter: Beta-trace protein and neural-tube defects.


Letter: HL-A and infective sacroileitis.


Letter: Neural-tube defects and subfertility.


Letter: Offspring of chronic alcoholic women.


Letter: Hepatomas and oral contraceptives.


Letter: Oral contraceptives and health.

Letter: Oral contraceptives and health.


Letter: Geriatrics.

Letter: Geriatrics.


Letter: Diet and exercise in coronary heart-disease.


Letter: Growth hormone and diabetic retinopathy.


Letter: Plasma-catecholamines in sleeping hypertensives.


Letter: Transfusion of fresh blood in the newborn.


Letter: Body-temperature and myasthenia.


Letter: Effects of feeding on blood-gases in a newborn infant.


Letter: Hypotensive effect of angiotensin-converting-enzyme inhibitor SQ 20,881.


Letter: What are we playing at?

Letter: What are we playing at?


Letter: Cadaver kidney donation.

Letter: Cadaver kidney donation.


Letter: Teaching biochemistry to medicals.


Letter: Occupational hazards of businessmen in West Africa.


Letter: Viruses in gastroenteritis.

Letter: Viruses in gastroenteritis.


Letter: Intermittent compression: a new principle in treatment of wounds?


Letter: Dimethylformamide: a cause of acute pancreatitis?


Letter: Tuberculosis of the spine.

Letter: Tuberculosis of the spine.


Letter: Unusual tubular structures in brain reticulum-cell sarcoma.


Letter: Reverse transcriptase in plasma of patients with breast cancer.


Letter: Skin wrinkling in cystic fibrosis.


Letter: A fashionable boot syndrome?

Letter: A fashionable boot syndrome?


Letter: Potential laboratory hazard from vacuum tubes.


Letter: Breast tumours and hirsutism.

Letter: Breast tumours and hirsutism.


Letter: 1,25-Dihydroxycholecalciferol and 1 alpha-hydroxycholecalciferol in hypoparathyroidism.


Letter: Brain-levels of monoamine oxidase in depression.


Heterogeneity of rat brain mitochondrial monoamine oxidase.


The relief of dysphagia by Celestin tube.


Clinical use of bleomycin: two case reports and review of toxicity.


Immunoglobulin deficiency disorders.

Immunoglobulin deficiency disorders.


Automatic conversion of slide synchronizing pulses on audio tape.


Audiovisual production in a department of medical communications.


Light and electron microscopic studies on the cytochrome c adjective reaction for the demonstration of acid mucopolysaccharide.


Initial surgical management of renal failure.


Educating the patient who won't read.

Educating the patient who won't read.


Antigammaglobulin antibodies in rheumatic fever.


Monoaminergic influence on testosterone-activated copulatory behavior in the castrated male rat.


Copulatory behavior in the male rat after impaired monoaminergic neurotransmission.


Ovalbumin mRNA, complementary DNA and hormone regulation in chick oviduct.


A reappraisal of the value of the EEG in subdural haematoma. A report on 86 patients, with a follow-up study.


Use of video-tape to change behavior.

Use of video-tape to change behavior.


Renin release and renin-substrate reaction in the isolated perfused rabbit kidney.


Errors in DNA replication as a basis of malignant changes.


The variants of the group-specific component. A review of their distribution in human populations.


Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus.


Relation between Escherichia coli K1 capsular polysaccharide antigen and clinical outcome in neonatal meningitis.


Clinical, bacteriological, and immunological characterisation of ampicillin-resistant Haemophilus influenzae type B.


Maternal enzymes of galactose metabolism and the "inexplicable" infantile cataract.


Editorial: Micrococci in urine.

Editorial: Micrococci in urine.


Undergraduate training in occupational medicine.


Letter: Inhibition of labour by prostaglandin antagonists in impending abortion and preterm and term labour.


Maurice Benjamin Strauss.

Maurice Benjamin Strauss.


Letter: Diagnosing Corynebacterium vaginale (Haemophilus vaginalis) by means of wet mounts and direct stained smears.


Fibrinolytic inhibitors in human retroplacental blood.


Common antigenic structures of HL-A antigens. II. Small fragments derived from papain-solubilized HL-A antigen molecules.


Comparative inhibitory action of D- and L-tryptophan on the effect of d-lysergic acid diethylamide in vitro.


Editorial: Surgical training in the E.E.C.


Growth-hormone dependence among human breast cancers.


Letter: Haematological effects of gallbladder disease.


Letter: Mebendazole and hydatid cysts.

Letter: Mebendazole and hydatid cysts.


Letter: Vitamin E and oxygen consumption.


Plasma TSH and serum T-4 levels in long-term follow-up of patients treated with 131-I for thyrotoxicosis. In February 1972 58% of patients euthyroid after iodine-131 therapy given for thyrotoxicosis between 1954 and 1966 had a high plasma TSH (>7.4 muU/ml) and 42% a normal plasma TSH level. A group of 69 of the euthyroid patients with high plasma TSH levels (25.0+/-2.0 muU/ml) in 1972 were re-examined 15 and 24 months later. The mean plasma TSH in the 66 patients remaining euthyroid at 15 months was 22.6+/-1.8 muU/ml, while three patients had become hypothyroid. At 24 months 64 of the patients were still available for study, of whom 61 remained euthyroid with a mean plasma TSH of 21.6+/-2.0 muU/ml, and a further three had become hypothyroid.All of a group of 61 of the euthyroid patients with normal plasma TSH levels (4.0+/-0.2 muU/ml) in 1972 remained euthyroid at 24 months with a mean plasma TSH of 4.1+/-0.3 muU/ml, though the plasma TSH level had become slightly raised in three.The mean serum T-4 level in the euthyroid patients with a high plasma TSH was significantly lower, though still in the normal range, than that in the euthyroid patients with a normal plasma TSH both in 1972 and in 1974.Since no patient with a normal plasma TSH level after iodine-131 treatment six to 18 years earlier for thyrotoxicosis developed hypothyroidism over a two-year period, the follow-up of such patients need not be so rigorous as that of similarly treated euthyroid patients with raised plasma TSH levels in whom hypothyroidism developed at the rate of 5% per year.


Quantitative study of the histocompatibility antigens on the surface of normal and leukaemic cells in mice. II. Quantitative variation in the expression of various H-2 specificities on the lymphoid cells from the B10 coisogenic strains of mice and their hybrids.


Polyovular Graafian follicles in a newborn kitten with a study of polyovuly in the cat.


Contractile protein changes in the regenerating rat liver.


Verification of the previously reported t(3p minus:17q plus) by G banding.


Vaginal adenosis: detection by colposcopy and iodine staining.


Toxicants occurring naturally in foods.

Toxicants occurring naturally in foods.


A modified alcian blue-periodic acid Schiff stain for epoxy-embedded atherosclerotic arteries.


Biopsy of the pancreas.

Biopsy of the pancreas.


Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D, L-alanyl--poly-lysyl. The genetic control of the antibody response to a synthetic polypeptide antigen designated poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys [(T, G)-A--L] has been studied in congenic high responder C3H.SW (H-2(b)) and low responder C3H/HeJ (H-2(k)) strains of mice. This response is controlled by the Ir-1 gene and is H-2 linked. The method employed was to study the ability of specifically primed or "educated" T cells of each strain to produce cooperative factors for (T, G)-A--L in vitro. Such factors have been shown to be capable of replacing the requirement for T cells in the thymus-dependent antibody response to (T, G)-A--L in vivo. The T-cell factors produced were tested for their ability to cooperate with B cells of either high or low responder origin by transfer together with bone marrow cells and (T, G)-A--L into heavily irradiated, syngeneic (for bone marrow donor) recipients. Direct anti-(T, G)-A--L plaque-forming cells were measured later in the spleens of the recipients. The results showed that (a) educated T cells of both high and low responder origin produced active cooperative factors to (T, G)-A--L, and no differences between the strains in respect to production of T-cell factors could be demonstrated; and (b) such factors, whether of high or low responder origin, cooperated efficiently with B cells of high responder origin only, and hardly at all with B cells of low responder origin. The conclusion was drawn that the cellular difference between the two strains lies in the responsiveness of their B cells to specific signals or stimuli received from T cells. As far as could be discerned by the methods used, no T-cell defect existed in low responder mice and the expression of the controlling Ir-1 gene was solely at the level of the B cells in this case.


Serum alpha2-globulins in breast carcinoma.


Editorial: Chlamydia and genital infection.


Letter: Mobile coronary care.

Letter: Mobile coronary care.


Norepinephrine-sensitive properties of C-6 astrocytoma cells.


Antibody response of inbred mouse strains to ordered tetrapeptides of tyrosine and glutamic acid attached to multichain polyalanine or polyproline. Tyr-Tyr-Glu-Glu is a major determinant of the random poly-(Tyr, Glu)-polyDLAla--polyLys. Five inbred mouse strains which represent high and low responders to the random synthetic polypeptide poly(LTyr,LGlu)-polyDLAla--polyLLys, designated (T, G)-A--L, to which the immune response is controlled by an H-2-linked gene, were immunized with three ordered tetrapeptides composed of tyrosine and glutamic acid attached either to multichain poly-DL-alanine or to polyproline. Only one of the three antigenic determinants, namely tyrosyl-tyrosyl-glytamyl-glutamic acid (T-T-G-G), resembled the random peptide (T, G) in the pattern of immune responses elicited against it, and in the cross-reactivity of the specific antibodies with (T, G)-A--L. The immune response pattern to the other two ordered tetrapeptides, T-G-T-G and G-T-T-G, was different from that obtained with (T, G)-A--L, and no cross-reactivity was detected between the antibodies provoked with these peptides and (T, G)-A--L. Thus, it is suggested that T-T-G-G is a major determinant in the random (T, G)-A--L.


Editorial: A blood-lymphocyte test for cancer?


Letter: Cytotoxic lymphocytes from normal donors.


Charles Wilfred Lawson.

Charles Wilfred Lawson.


Adjuvant effect of birch pollen on antibody production.


Structural aspects of histamine release in rat peritoneal mast cells. Effects of adenosine 5'-triphosphate and role of calcium.


Immunoglobulin production in chicken Harderian glands.


Identification in the thyroid of antithyroglobulin antibodies in the fibrous variant of Hashimoto's thyroiditis.


Practical synovial fluid examination.

Practical synovial fluid examination.


Aqueous solutions of some basic dyes in the specific staining of acid hydrolysed DNA.


Histochemical studies in stomatal apparatus of Phaseolus mungo Linn. 3. Localization of ascorbic acid and peroxidase and their functional significance.


Metachromasia through uranyl-ions method for nucleic acids detection in the vegetal cell.


Analysis of synaptic vesicles in F-type axon terminals.


Effects of Rauscher leukaemia virus on the immune system in susceptible and resistant mouse strains.


Serological studies on Pseudomonas aeruginosa O group lipopolysaccharides.


Effects of chemotherapy on the evolution of schistosomiasis japonica in chimpanzees.


Studies on the regulation of carbohydrate synthesis during growth and differentiation of Physarum polycephalum. I. Activity of UDPGpyrophosphorylase during spherulation.


Prostaglandins and in vitro TSH-dependent iodide binding by rat thyroid glands.


Staining and fixation of unsaturated membrane lipids by osmium tetroxide. Crystal structure of a model osmium(VI) di-ester.


Immunofluorescent identification of a human thymic specific antigen.


Histochemistry and fine structure of endocrine cells in foetal lungs of the rabbit, mouse and guinea-pig.


Time course and subcellular distribution of the radioactivity in a synaptic terminal after supplying the perikaryon with labelled glutamic acid.


The innervation of Purkinje fibres in the atrium of the avian heart.


Electronmicroscopic comparison of the acid-fast and non-acid-fast strain of Mycobacterium phlei.


Comment on the paper by Marshall and Horobin "Measurements of the Affinities of Basic and "Mordant" Dyes for Various Tissue Substrates".


Demonstration of orderly arranged acidic groups in amyloid by alcian blue.


Studies on mouse liver urate oxidase. 3. Fine localization of urate oxidase in liver cells revealed by means of ultracryotomy-immunoferritin method.


Ultrastructural differences in cell membranes of erythrocytes myeloid and lymphoid cells as shown by topo-optical reactions.


Antiprotease activity in tears and nasal secretions.


Organization of human mitotic chromosomes.


The structure of human high density lipoprotein and the levels of apolipoprotein A-I in plasma as determined by radioimmunoassay. The major apoprotein of high density lipoprotein is apolipoprotein A-I (ApoA-I). In addition to being a structural component of this class of lipoproteins, ApoA-I also has a physiologic role as an activator of lecithin-cholesterol acyl transferase, an enzyme important in the metabolism of all lipoproteins. To measure ApoA-I content in human plasma, to assess its immunologic activity in hyperlipoproteinemia, and to carry out certain structural studies of high density lipoproteins, we have developed a double antibody radioimmunoassay. ApoA-I, isolated by gel filtration, was used to produce monospecific antisera. ApoA-I was iodinated by chloramine-T and the resulting [(125)I]-ApoA-I was purified by gel filtration. > 85% of [(125)I]-ApoA-I was precipitated by antibody, and 90% of bound [(125)I]ApoA-I was displaced by "cold" ApoA-I. Other lipoproteins and apoproteins did not react. Plasma and high density lipoprotein from normals and subjects with hyperlipoproteinemia displaced counts in parallel with ApoA-I, suggesting that the same antigenic determinants were reacting with antibody on lipid-free and lipid-associated ApoA-I. However, less than 5% of ApoA-I of high density lipoprotein reacted in the assay. Removal of the lipid by extraction increased the reactivity of ApoA-I in high density lipoprotein 15-20-fold; thus more than 95% of the ApoA-I molecules in "intact" high density lipoprotein are unreactive with antibody. Normal and hyperlipoproteinemic plasma and high density lipoproteins isolated from the same subjects continued to display parallelism with ApoA-I standard after lipid extraction, suggesting that ApoA-I of normal and hyperliproteinemic subjects are immunologically identical. About 90% of ApoA-I was in the d 1.063-1.21 fractions of normal plasma, trace quantities were found in the lipoproteins of d < 1.063, and the rest (about 10%) was in the d > 1.21 fraction. Normal plasma levels, assessed in extracted plasmas with a precision of 8%, were 100+/-35 mg/dl. Levels were normal in small groups of subjects with types II and IV hyperlipoproteinemia and high in pregnancy. However, larger population studies need to be performed to determine the distribution of ApoA-I levels in the various hyperlipoproteinemias.


Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. Wiskott-Aldrich syndrome is characterized by numerous humoral and cellular immune abnormalities including anergy, defective antibody production, and increased immunoglobulin synthesis. To define better the mechanisms of defective cellular immunity in this disorder, lymphoproliferative responses, lymphokine production, and the chemotactic responsiveness of mononuclear leukocytes (MNL) from patients with Wiskott-Aldrich syndrome were quantitated. Peripheral blood lymphocytes from these patients produced normal amounts of a lymphocyte-derived chemotactic factor (LDCF); however, their lymphoproliferative responses were frequently depressed, particularly to antigenic stimuli. In the absence of exogenous antigens or mitogens, lymphocytes from patients with Wiskott-Aldrich syndrome produced significantly more LDCF than unstimulated normal lymphocytes. In fact, this unstimulated LDCF production frequently approached the level produced by normal cells only after antigen or mitogen stimulation. The chemotactic responsiveness of MNL from Wiskott-Aldrich syndrome patients was impaired, particularly in those patients with the highest rates of unstimulated LDCF production. Furthermore, normal MNL chemotactic responsiveness could be impaired by preincubation of these cells in either LDCF or plasma from Wiskott-Aldrich syndrome patients. These observations suggest that the regulation of LDCF synthesis is abnormal in Wiskott-Aldrich syndrome, and that a humoral chemotactic inhibitor, perhaps LDCF, "deactivates" the circulating MNL of patients with this syndrome.


Enhancement of amphetamine action after interruption of ascending serotonergic pathways.


Thyroid-stimulating activity and chorionic gonadotropin. The nature of the substance with thyroid-stimulating activity (TSA) present in human chorionic gonadotropin (hCG) prepared from pregnancy urine was investigated. In the mouse thyrotropin bioassay, the characteristic maximum of blood radioactivity obtained with the TSA in hCG preparations occurred after that obtained with pituitary thyrotropin (hTSH) but before that obtained with long-acting thyroid stimulator. Antiserum to the alpha subunit of hCG produced significant neutralization of the TSA in hCG. Significant antagonism of hTSH biologic activity was achieved with certain doses of hCG, suggesting that the TSA in hCG was a partial agonist of hTSH. This antagonism was neutralized by antiserum to the beta subunit of hCG. These immunologic results suggest that the substance with TSA in hCG preparations contains antigenic determinants similar to those of both the alpha and the beta subunit of hCG. Amounts of highly purified hCG and crude commercial hCG of equal immunologic activity were biologically indistinguishable in the bioassay for TSA. Both hCG immunoreactivity and the TSA in hCG adsorbed to concanavalin A and eluted with 0.2 M methyl alpha-D-glucopyranoside. These results are consistent with the hypothesis that TSA is an intrinsic property of hCG or of a glycoprotein molecule physicochemically, biologically, and immunologically similar to hCG.


Electron microscopy study of reovirus reaction cores. A combined staining and shadowing method has been used to enhance the contrast of both reovirus cores and the RNA product that they have synthesized. After limited synthesis when all RNA strands associated with the core are nascent, many cores are observed that have more than 10 strands associated with each particle. The lengths of individual nascent mRNA molecules are not identical: many strands are extruded in the form of loops. These observations are consistent with the notion that synthesis of individual mRNA molecules occurs simultaneously at different rates at a number of different sites. The sites of extrusion are probably the 12 hollow projections located on the surface of the core.


Charting a way through the wards.

Charting a way through the wards.


Properties of feline leukemia virus. I. Chromatographic separation and analysis of the polypeptides. Rickard's strain of feline leukemia virus (FeLV) contains two large glycoproteins and five smaller polypeptides of molecular weights 100,000 (gp >/= 100), 70,000 (gp70), 30,000 (p30), 21,000 (p21), 15,000 (p15), 11,200 (p11), and 10,000 (p10) when chromatographed on 6% agarose in the presence of 6 M guanidine hydrochloride (GuHCl). P21 is a minor component which was not previously described for mammalian leukemia-sarcoma viruses and may be analogous to the seventh protein found in avian viruses. Analysis on 4% agarose and by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that gp >/= 100 is actually >/= 200,000 daltons and dissociates to polypeptides of approximately 100,000 to 115,000 daltons, whereas gp70 can be resolved into six stained bands ranging from 40,000 to 80,000 daltons despite being rechromatographed as a single symmetrical peak on 6% agarose. Rechromatography on 8% agarose was found to be more effective than on 6% agarose or sodium dodecyl sulfate polyacrylamide gel electrophoresis for obtaining the five small polypeptides, especially p11 and p10, in a highly purified form suitable for further analysis and for obtaining more precise estimates of their molecular weights, especially when done by co-chromatography with iodinated standard proteins markers. Rechromatographed p30, p21, p15, p11, and p10 had molecular weights of 27,000, 18,000, 15,000, 12,000, and 12,000 respectively, by co-electrophoresis with the marker proteins on sodium dodecyl sulfate polyacrylamide gel electrophoresis, clearly establishing that the latter two FeLV polypeptides comigrate to form one less band when compared to elution from agarose. The isoelectric points of p30 and p15 were 5.5 and 8.9, respectively, after renaturation from GuHCl and 5.6 and 8.7, respectively, when isolated from Tween-ether treated virus. Rechromatographed p30, p15, and p11, renatured by removing GuHCl with dialysis, reacted only with their homologous antisera in immunodiffusion analysis, indicating that they are immunologically unrelated. Also the interspecies gs-3 determinant associated with p30 could be regained by removal of GuHCl.


Diabetes mellitus, carcinoma of both breast. Nursing care study.


Checking a plaster--how and why.

Checking a plaster--how and why.


Binding of folic acid to serum proteins. 3. The effect of pernicious anaemia.


The relevance of immune reactions in acute favism.


The blood count during the ovarian cycle.


Intraepithelial cervical neoplasia in women using intrauterine devices and long-acting injectable progestogens as contraceptives.


Comparison of serum vs eye bank storage of cat corneas.


Esterase activity of Aspergillus niger in continuous culture.


Experimental corneal wound strength. 7-0 Silk vs 10-0 monofilament nylon.


Immunofluorescent detection of antibodies to ocular melanomas.


Osmium-zinc iodide staining and the quantitative study of central synapses.


The role of the nervous system in regeneration, growth and cell differentiation in Hydra. I. Distribution of nerve elements during hypostomal regeneration.


The biochemical nature of the cell periphery of the salt gland secretory cells of fresh and salt water adapted mallard ducks.


Radioimmunoassay of alpha-fetoprotein. I. Technique and serum levels in the normal adult.


G-band patterns, chromosomal homologies, and evolutionary relationships among wild sheep, goats, and aoudads (Mammalia, Artiodactyla).


Observations on nucleolar staining with osmium tetroxide.


Radioimmunoassay of alpha-fetoprotein. II. Studies in patients suffering from hepatic diseases.


Lysosomal function of juxtaglomerular granules.


Lung inclusion bodies: different ultrastructure in simian and non-simian mammals.


Some structural evidence in support of functional integration within the cephalic neuroendocrine complex of Periplaneta americana L.


New antilymphoma L-asparaginase from Fusarium species.


Fluorescence banding pattern of human and mouse chromosomes with a benzimidazol derivative (Hoechst 33258).


Frequency of 9qh+ and risk of chromosome aberrations in the progeny of individuals with 9qh+.


Othe relevance of non-histone proteins to the production of Giemsa banding patterns on chromosomes.


The formation of the abnormal chromosome in balanced homologous Robertsonian translocation carriers.


Familial short arm deletion of chromosome no. 15.


Projections from the striate cortex to the diencephalon in the squirrel monkey (Saimiri sciureus). A light microscopic radioautographic study following intracortical injection of H3 leucine.


Blocking of the effect of delta1 tetrahydrocannabinol (delta1THC) on spontaneous motor activity in the rat by immunization with a protein conjugate of delta1THC.


Route of antigen administration for tolerance production.


Destined for fame--but one would not think it.


"Adolescent" cystinosis. A case presentation and review of the recent literature.


"Generalized" epileptic seizures elicited by electrical stimulation of the frontal lobe in man.


Trypsin-banding procedure for avian chromosomes.


A carcinoid saga.

A carcinoid saga.


A bleomycin-inactivating enzyme in mouse liver.


A case of a girl with a 21 ring chromosome.


A clinical study on 29 cases of debatable STS and TPI seroreactions in Greenland.


A comparative evaluation of the treatment of hyperthyroidism.


A comparative study of behavioural aspects in encopretic children.


A double isotope technique for estimating insulin degradation in vivo.


A familial, balanced 2-5 translocation associated with trisomy 21 in one individual.


A method for the determination of polycyclic hydrocarbons in air-borne particulates from urban and other atmospheres.


A method for obtaining ultrathin frozen sections from fresh or glutaraldehyde-fixed tissues.


A method for the quantitative estimation of blood-brain barrier (BBB) damage.


A new temporary pacing catheter with improved sensing and safety characteristics.


A patient with prostatectomy.

A patient with prostatectomy.


A rapid, new method for quantitative analysis of human amylase isozymes.


A safer method of dilating oesophageal strictures.


A procedure for selective acid extraction, staining and quantitative measurement of histones in Allium root nuclei.


A serological tool for the diagnostics of virus B hepatitis.


A simple visual pattern stimulator.

A simple visual pattern stimulator.


A sliced gel assay for some enzymes which utilize guanine as substrate.


A survey of the chymotryptic peptides of the assembly protein of bacteriophage MS2.


A staining method of epoxy-embedded lymphatic and hemopoietic tissues in autoradiograms.


A study of Danish snuff-induced oral leukoplakias.


A systematic method for the detection of experimentally induced hyperplasia and early neoplasia in the urinary bladder.


A working model for oncogenic DNA virus replication.


Aberrant restriction and modification of a colicin-tolerant strain of Escherichia coli.


Accumulation of coiliodal 198Au in normal bone marrow of rabbits. Microscopic and autoradiographic investigation.


Accumulation of digoxin by canine choroid plexus.


Acid mucosaccharide-containing structures in the gall bladder epithelium of the rabbit as seen with the electron microscope.


Acridine orange staining of epithelial cells in strong salt solution.


Acute lymphocytic leukemia. Cytochemistry and ultrastructure.


Age related development of humoral immunity in normal children and in children with immunodeficiencies.


Adrenalectomy with chemotherapy in the treatment of advanced breast cancer: objective and subjective response rates; duration and quality of life.


Age variation in the uptake of radioiodine in thyrotoxicosis.