5-Fluoropyrimidine-resistant mutants of pneumococcus. Three classes of 5-fluorpyrimidine-resistant mutants of Diplococcus pneumoniae have been characterized. The mutant strain upp is resistant to high concentrations of the fluoropyrimidine bases fluorouracil (FU) and fluorocytosine (FC); strain upp has a defective uridine monophosphate pyrophosphorylase. The mutant strain udk is resistant to inhibition by fluorouridine (FUR) and exhibits defective uridine kinase activity. The mutant strain fun is resistant to inhibition by the nucleosides fluorodeoxyuridine, fluorodeoxycytidine, and FUR, but shows normal activity for all pyrimidine pathway enzymes tested. This strain may be defective in the activity of a transport system that governs the cellular uptake of pyrimidine ribo- and deoxyribonucleosides. Biochemical studies on wild-type and fluoropyrimidine-resistant pneumococci are discussed with respect to the transport and early metabolism of preformed pyrimidine precursors by this organism.


Development of circadian rhythm of hepatic tyrosine aminotransferase in growing rats.


On the significance of anaphylactic catecholamine release in guinea pigs.


Effect of 2-endo-aminonorbornane-2-carboxylic acid upon insulin secretion and fluorescence of reduced pyridine nucleotides of isolated perifused pancreatic islets.


Phenobarbital inducible drug monooxygenase activity in the small intestine of mice.


Hypothalamo-hypophyseal neurosecretory system in Rana temporaria in early ontogenesis.


Enzymatic interconversion of active and inactive forms of enzymes.


Physical examination of four-year-old children.


The mechanisms of nitrogen assimilation in pseudomonads.


Turner-phenotype in males.

Turner-phenotype in males.


Immunology in Hodgkin's disease.

Immunology in Hodgkin's disease.


Pharmacokinetics of the  -adrenergic blocker sotalol in dogs.


Topical mosquito repellents. V. Benzyl ethers.


Histo- and bio-chemical observations on  -glutamyl transpeptidase in liver diseases.


1,5-diphenyl-3-dimethylaminopyrrolidine: a long-acting histamine antagonist.


Angina pectoris. Recent advances in understanding and implications for management.


The adrenal dopamine as an indicator of adrenomedullary hormone biosynthesis.


On the role of sterol hydroperoxides in steroid metabolism.


Functional components and mechanism of action of the resolved liver microsomal enzyme system catalyzing fatty acid, hydrocarbon and drug hydroxylation.


On the significance of drug-induced spectral changes in liver microsomes.


Ultrastructural changes in larval wax moth, Galleria mellonella, midgut and silk gland after exposure to chlorcyclizine, phenobarbital, or promazine.


Survival of Toxoplasma gondii in mosquito cell lines and establishment of continuous infection in Vero cell cultures.


In vitro bactericidal and associated metabolic activities of mouse spleen cells. Spleen cell suspensions from AKR and CD-1 mice are able to kill Escherichia coli in vitro. The optimal ratio of splenocytes to bacteria for this activity is 1: 1. Incubation of these cells with inert polystyrene latex spherules (0.81 mum diameter) results in a fourfold increase in glucose-1-(14)C oxidation. Under these conditions, there is also a 2.5-fold increase in both reduced nicotinamide adenine dinucleotide phosphate oxidase activity and formate oxidation. Spleen cell fractions have been shown to have significant peroxidase activity. This has been quantitated by the guaiacol oxidation method. The 20,000 x g pellet fraction of spleen cell homogenate can kill E. coli when H(2)O(2) and chloride ions are added and the reaction is carried out at pH 5.5 and 37 C.


Clinical nutrition applications of space food technology.


Host factors and capsular typing of body fluid isolates in fulminant pneumococcal infections. A 10-year retrospective study was made to determine the spectrum of underlying disease in, and the capsular types of pneumococci isolated from, blood and body fluids of 140 hospitalized patients. Fifteen serotypes were found among 82 typed isolates, 53% of which were types 8, 14, or 23. There was a predominance of males and a high incidence of underlying pneumonia, chronic liver disease, nephrotic syndrome, cerebrospinal fluid rhinorrhea, and malignancy. Mortality rates were higher among the very young and aged, and the immunologically comprised host at either extreme of life was more susceptible to disseminated pneumococcal infection. Pneumococci of the higher capsular types were prominent in children, and those of the lower types in adults, a finding in agreement with other recent studies.


Skylab menu development.

Skylab menu development.


Undescended testes.

Undescended testes.


The activity of sulphonamides and some other chemicals against mosquito larvae.


Antigenicity of aortic valve allografts.


Biting insects.

Biting insects.


The effects of environmental isolation on behavior and regional rat brain tyrosine hydroxylase and tryptophan hydroxylase activities.


Dental caries in English school children: a longitudinal study.


Freeze-dried bone as a meatal implant.

Freeze-dried bone as a meatal implant.


Beta-adrenergic blockers in benign essential tremor.


A comparison of beta-blocking agents.

A comparison of beta-blocking agents.


Bovine lens  -glutamyl transpeptidase.

Bovine lens  -glutamyl transpeptidase.


Even small hospitals need blood gases.

Even small hospitals need blood gases.


Herniagrams in undescended testes and hydroceles.


Bromination of phenothiazine tranquiliziers: a method for sensitive and specific detection.


Palpebral ptosis as an index of neuroleptic activity.


Drug defaulting by patients on long-acting phenothiazines.


Purification and comparative properties of isoenzymes of nicotinamide-adenine dinucleotide phosphate-isocitrate dehydrogenase from rat heart and liver. 1. Rat liver and heart major isoenzymes of NADP-isocitrate dehydrogenase have each been purified about 100-fold by a combination of ammonium sulphate fractionation and chromatography on ion-exchange cellulose and their properties compared. 2. The properties were similar in respect of pH, inhibition by Hg(2+) and Michaelis constants for isocitrate and NADP. 3. Some of the properties of the isoenzymes were different. 4. The heart isoenzyme was activated about 210% by 0.8m-ammonium sulphate whereas the liver isoenzyme was unaffected. The heart isoenzyme showed greater sensitivity to inactivation by heat (30 degrees C for 30min), whereas the liver isoenzyme was more sensitive to inactivation by p-chloromercuribenzoate and by Cu(2+). 5. The Michaelis constants with 3-acetylpyridine-adenine dinucleotide phosphate showed a twofold difference between liver and heart isoenzyme. 6. The differential sensitivity to heat and its mainly non-cytoplasmic location may be an explanation of the failure of plasma isocitrate dehydrogenase activity to increase after a myocardial infarction.


Inactivation of tyrosine aminotransferase in neutral homogenates and rat liver slices. Inactivation of tyrosine aminotransferase induced in vivo by triamcinolone was studied in a homogenate incubated at neutral pH values. The integrity and the presence of subcellular particles together with a compartment of acidic pH are necessary for inactivation of tyrosine aminotransferase. It is suggested that tyrosine aminotransferase is inactivated inside lysosomes. The system responsible for inactivation of tyrosine aminotransferase was partially purified and identified with lysosomal cathepsins B and B(1). Inactivation of tyrosine aminotransferase in liver slices is controlled by the amino acid concentration and strongly stimulated by cysteine. 3,3',5-Tri-iodo-l-thyronine reversibly and strongly decreases the rate of inactivation of tyrosine aminotransferase. The effect is not due to an increased rate of tyrosine aminotransferase synthesis.


Effect of halothane upon rabbit brain mitochondria.


Effect of some 6-substituted benzo(a)pyrene derivatives upon liver enzymes and ascorbic acid excretion in mice.


Relation between the oxidation state of nicotinamide-adenine dinucleotide and the metabolism of spermatozoa. 1. The existing procedures for extraction of oxidized and reduced nicotinamide coenzymes were adapted to spermatozoa to overcome the coenzyme-degrading activity of seminal plasma. 2. The content of total NAD(+) and NADH was determined in the spermatozoa of ram, bull, boar, stallion and cock. NADP(+) and NADPH were not detected in ram spermatozoa. 3. The oxidation state of sperm NAD depended on the seminal plasma, the removal of which produced a change in the percentage oxidation state of the coenzyme, 100x[NAD(+)/(NAD(+)+NADH)], without altering the total content of NAD(+)+NADH. 4. In suspensions of washed ram spermatozoa, incubated anaerobically at 25 degrees C, the percentage oxidation state of NAD declined with increasing spermatozoa concentration. 5. When ram or boar spermatozoa that had been previously washed and resuspended in Ringer phosphate medium, were incubated anaerobically at 25 degrees C with various substances, pronounced effects on the percentage oxidation state of NAD could be observed with l-lactate, pyruvate, oxaloacetate, dihydroxyacetone, formaldehyde and glyceraldehyde; sorbitol and acetoacetate acted only on ram spermatozoa; fructose, glucose, mannose and acetaldehyde acted predominantly on boar spermatozoa. Formaldehyde lowered the (NAD(+)+NADH) content of ram spermatozoa, but none of the other substances had a comparable effect. 6. The percentage oxidation state of sperm NAD was not influenced by exogenous cysteine, cystine, ergothioneine or ascorbate. 7. A highly active sorbitol dehydrogenase could be prepared from ram, but not from boar, spermatozoa. 8. Sorbitol, acetoacetate and 3-hydroxybutyrate effectively supported the respiration of ram, but not boar, spermatozoa. 9. ;Cold shock', resulting from sudden cooling of spermatozoa, abolished motility completely and irreversibly but produced only a slow and partial decrease in the total NAD content. Slight over-heating, sufficient to produce loss of motility, had no adverse effect on the total NAD content. 10. Storage of ram sperm at 14 degrees C produced only a small decrease of NAD after 2 days, but subsequently the loss became greater.


Effect of calcium, potassium and sodium on tyrosine hydroxylase activity in different regions of the rat brain.


Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.


The inhibition of the Neurospora crassa nitrate reductase complex by metal-binding agents.


Purification and properties of NAD nucleosidase from Fusarium nivale.


Pharmacological actions of a new  -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. 1. The effects of (-)-isoprenaline and the new beta-adrenoceptor agonist, MJ-9184-1, on the lungs, on the cardiovascular system, and on slow contracting skeletal muscle have been compared in cats under chloralose anaesthesia.2. Both amines reduced the increases in airways resistance produced by 5-HT, depressed incomplete tetanic contractions of the soleus muscle, lowered the blood pressure and produced an increase in heart rate. In comparison with (-)-isoprenaline, MJ-9184-1 had a long duration of action.3. The effects of MJ-9184-1 and (-)-isoprenaline were antagonized by the beta-adrenoceptor antagonist, propranolol.4. MJ-9184-1 was approximately half as potent as (-)-isoprenaline in its effects on pulmonary resistance and soleus muscle contractility, and one seventh as potent in producing chronotropic effects in the heart.5. These results suggest that MJ-9184-1 possesses some specificity as a beta(2) receptor stimulant.


The effect of certain  -adrenoceptor antagonists on overdrive suppression. 1. Propranolol, as the racemate and the (+)- and (-)-isomers (400 mug/l.) and practolol (50 mg/l.) were tested for their effects on atrial and ventricular rates and on the duration of overdrive suppression (ODI) in isolated perfused cat hearts with surgically-induced heart block.2. Racemic propranolol and the (+)- and (-)-isomers prolonged ODI and slowed the rate of the ventricular pacemaker; the (+)- and (-)-isomers also reduced the rate of the atrial pacemaker. Practolol shortened ODI and increased the rate of the atrial and ventricular pacemakers.3. The (+)- and (-)-isomers were more potent than the racemate; the (-)-isomer was more potent than the (+)-isomer. The results suggest there is a stereospecific mechanism involved in the biological distribution of propranolol.4. Twenty-four hours after reserpine treatment (5 mg/kg, i.p.) practolol continued to increase the rate of the atrial and ventricular pacemakers but did not shorten ODI.5. The mechanism by which these agents affect myocardial excitability and automaticity is discussed.


The mechanism of the facilitatory action of edrophonium in cat skeletal muscle. 1. The effects of edrophonium have been observed in the transversely cut tenuissimus muscle of the cat.2. Concentrations of edrophonium 10(-7)M to 10(-5)M increased the amplitude of the end-plate potential (e.p.p.) but produced no greater increase in time course than previously observed in curarized muscle.3. When the e.p.p. and gross nerve action potential were recorded simultaneously, antidromic discharges were observed in the motor nerve concomitantly with repetitive e.p.ps in the presence of edrophonium.4. Edrophonium produced no effect on the input resistance or equilibrium potential of the end-plate.5. The fractional release of transmitter was significantly increased by edrophonium but there was no increase in the quantal release of transmitter in the transversely cut muscle preparation.6. In curarized muscle edrophonium also increased the quantal release, the size of the available store of transmitter and the rate of refilling of the available store.7. It is concluded that edrophonium facilitates transmission to skeletal muscle by inducing a repetitive antidromic discharge in the nerve, following orthodromic stimulation. The antidromic discharge propagates by axon reflex to other nerve terminals of the same motor unit producing repetitive e.p.ps. It is also suggested that edrophonium antagonizes tubocurarine by acting as a partial agonist at the motor nerve terminal.


Antagonism of some spasmogens of the rat seminal vesicle.


Cutaneous polyarteritis.

Cutaneous polyarteritis.


The effects of B2-adrenoceptor stimulants, salbutamol and terbutaline on gastric acid secretion and mucosal blood flow in conscious dogs with Heidenhain pouches.


Mode of action of verapamil.

Mode of action of verapamil.


Progressive increase in cell-mediated immunity against paternal transplantation antigens in parous mice after multiple pregnancies.


Vasodilator drugs and peripheral vascular disease.


Osteomalacia after prolonged glutethimide administration. Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.


Influence of anticholinergic-antiparkinsonian agents on the effects of narcoanalgesic drugs in the rat.


Beta-blocking drugs and human platelet aggregation in vitro.


Survival of irradiated hybrid female mice inoculated with maternal bone marrow: a preliminary report.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups.


Specific binding of  -adrenergic catecholamines to a subcellular fraction from cardiac muscle.


Biochemical aspects of drug and hormone action on adipose tissue.


Tritiated thymidine uptake by in vitro spleen lymphoid cell cultures following stimulation by GC murine leukemia virus.


Dynamics of accumulation of capsid proteins of type 1 adenovirus (immunofluorescence and cytofluorometric data).


Uridine kinase level in cells infected with western equine encephalomyelitis, vesicular stomatitis, pseudorabies and polyoma viruses.


Effect of lysozyme from human placenta on ectromelia virus.


Penetration of Venezuelan equine encephalomyelitis virus into the brain of guinea pigs and rabbits after intranasal infection.


Continuously recording photometry of fluorescence-labelled objects.


Interferon induced by tumoral DNA in a homologous system.


A complex natural focus of arboviruses on Glinyanyi Island, Baku Archipelago, Azerbaidzhan S.S.R.


Interferon production and infection caused by vesicular stomatitis virus in radiation chimeras.


Contribution to the problem of purity of interferon preparations.


Friend leukemia virus (FLV) elimination in feces of flies and fleas.


Continual serum interferon induced by prolonged drinking of tiloron solution.


On the "neuropathogenicity" mechanism of vaccinia virus.


A case of subacute sclerosing panencephalitis.


Anti-interfering and anti-interferon-inducing properties of adenociral soluble antigens.


Nuclear basic proteins of polyoma virus-infected cells cultivated in vitro.


-Glutamyl transpeptidase from Aspergillus terricola.


Metabolism of skeletal muscle following incomplete ischemia.


The pathogenesis of the graft-versus-host reaction in chicken embryos. Pathological changes in the yolk sac, thymus, bone marrow and bursa of Fabricius.


Changes in levels of tissue nucleotides and glutathione after hyperbaric oxygen treatment.


Fat metabolism in higher plants. Beta-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp. 1. An avocado supernatant fraction converted fatty acids of medium chain length (C(8)-C(12)) into a polar product. 2. The product was identified as the beta-hydroxy derivative of the substrate by g.l.c. and t.l.c. analysis. 3. For hydroxylation of the fatty acids, CoA, ATP and molecular oxygen were required. Acyl carrier protein gave some stimulation. The reaction took place with oxygen alone if acyl-CoA was the substrate. 4. Hydroxylation was maximal with decanoic acid but dodecanoic acid and octanoic acid were also very active. Acids of shorter or longer chain lengths were not hydroxylated. 5. NAD(+) concentration caused complete inhibition at 0.5mm and may be an important control mechanism for the reaction in vivo. 6. The reaction was inhibited by iodoacetamide and by bipyridyl and carbon monoxide, indicating involvement of thiol and heavy metal groups.


Proton translocation coupled to quinone reduction by reduced nicotinamide--adenine dinucleotide in rat liver and ox heart mitochondria. Measurements were made of the stoicheiometry of proton-translocation coupled to NAD(P)H oxidation by several quinones (duroquinone, ubiquinone(0), ubiquinone(1), ubiquinone(2)) in mitochondria from rat liver and ox heart. Observed stoicheiometries of protons translocated per mol of NADH oxidized (-->H(+)/2e(-) ratios; Mitchell, 1966) ranged from 0.75 (rat liver mitochondria with ubiquinone(1)) to 1.55 (ox heart mitochondria with ubiquinone(1) or ubiquinone(2)). Only the rotenone-sensitive pathway of NADH oxidation by quinone was able to support proton translocation. Correction of the observed -->H(+)/2e(-) ratios for the loss of reducing equivalents to the rotenone-insensitive pathway increased their value to approx. 2.0. It is concluded that the rotenone-sensitive NADH- ubiquinone reductase activity of the respiratory chain may be organized in the mitochondrial membrane as a proton-translocating oxidoreduction loop. The number of such loops between NADH and ubiquinone is one, and not two, as initially proposed by Mitchell (1966).


Adenine derivatives as neurohumoral agents in the brain. The quantities liberated on excitation of superfused cerebral tissues. Adenine nucleotides of guinea-pig neocortical tissues were labelled by incubation with [(14)C]adenine and excess of adenine was then removed by superfusion with precursor-free medium. Adenine derivatives released from the tissue during continued superfusion, including a period of electrical stimulation of the tissue, were collected by adsorption and examined after elution and concentration. The stimulation greatly increased the (14)C output, and material collected during and just after stimulation had a u.v. spectrum which indicated adenosine to be a major component. The additional presence of inosine and hypoxanthine was shown by chromatography and adenosine was identified also by using adenosine deaminase. Total adenine derivatives released from the tissue during a 10min period of stimulation were obtained as hypoxanthine, after deamination and hydrolysis of adenosine and inosine, and amounted to 159nmol/g of tissue. This corresponded to the release of approx. 7pmol/g of tissue per applied stimulus. The hypoxanthine sample derived from superfusate hypoxanthine, inosine and adenosine was of similar specific radioactivity to the sample of inosine separated chromatographically, and each was of higher specific radioactivity than the adenine nucleotides obtained by cold-acid extraction of the tissue.


Studies on urticaria pigmentosa.

Studies on urticaria pigmentosa.


Analysis of the role of H-2 genotypic and phenotypic differences in the spleen colony formation and lymphatic follicle repopulation by bone marrow cells.


Perforated jejunum due to primary Hodgkin's disease.


Viral labyrinthitis and transient phrenic nerve paralysis.


Blood lymphocyte nuclei activation and skin allograft rejection in mice.


Jaundice due to urinary tract infection.


Immediate transfusion reaction: fact and fancy.


Psychiatric emergencies of childhood and adolescence.


Gas masks permit identification of exhumed corpse.


Ureteral tumor.

Ureteral tumor.


Guided non-visualized nasal endotracheal intubation using a transtracheal Fogarty catheter.


Enigmatic fever during hemodialysis.

Enigmatic fever during hemodialysis.


Fetal breathing movements.

Fetal breathing movements.


Deficit of specific thymus-dependent lymphocytes in transplantation tolerance in the rat. Recovery from adoptively terminated transplantation tolerance was studied by utilizing formerly tolerant rats as donors of lymphocytes in local renal graft-vs.-host reactions (GVHR). The origin of the proliferating lymphocytes in the GVHR was studied by means of sex chromosome markers. A deficit of specifically reactive lymphocytes, while tolerance was in effect, was revealed by the continuing absence of autochthonous specifically reactive cells after tolerance was abolished in adult thymectomized chimeras. The findings are consistent with Burnet's hypothesis of the cellular basis of tolerance, but apply only to the T lymphocytes of donor origin which normally proliferate in these GVHR.


The changing nature of respiratory diseases in industry.


Adrenal and striatal tyrosine hydroxylase activity after methamphetamine.


The storage of noradrenaline in sympathetic ganglia.


Effect of adrenergic reactive drugs on Tetrahymena pyriformis in a chemically defined medium.


Catecholamines: strain differences in biosynthetic enzyme activity in mice.


Norepinephrine: dissociation of  -receptor binding from adenylate cyclase activation in solubilized myocardium.


Pharmacological therapy of angina pectoris.


Effects of chronic ethanol feeding on enzymes of rat brain and liver mitochondria.


Undescended testes.

Undescended testes.


Necrotizing angiitis in a methamphetamine user with hepatitis B--angiographic diagnosis, five-month follow-up results and localization of bleeding site.


Does cyclic-3',5'-AMP induce glutamine synthetase in embryonic neural retina?


The presence of the glycerol phosphate shuttle and energy dependent transhydrogenase in aortic mitochondria.


Chlorcyclizine N-demethylase activity in chick embryo hepatic cell culture.


Active oxidative decarboxylation of malate by mitochondria isolated from L-1210 ascites tumor cells.


Low magnitude transformation of estradiol to estrone in human endometrium.


Studies on peroxisones. 3. Further studies on the intraparticulate localization of peroxisomal components in the liver of the rat.


The effect of innervation, denervation, and muscle type on the reunion of skeletal muscle.


Redistribution of pyridoxal phosphate in the male rat liver as a result of repeated injections of hydrocortisone.


Occurrence of N-malonyl-D-alanine in pea seedlings.


The controlled use of vasodilator drugs in the management of hypovolaemia complicated by diminished cardiac function.


Pharmacodynamic studies of beta adrenergic antagonism induced in man by propranolol and practolol. The pharmacodynamic activities of two beta adrenergic antagonists, propranolol and practolol, were compared in eight hypertensive patients. The activity of each antagonist was established in relation to its blood concentration at maximal and submaximal adrenergic blockade defined by inhibition of exercise tachycardia. Maximal inhibition of exercise tachycardia was comparable with both drugs and averaged 74+/-7% of the control value during drug treatment. This inhibition was achieved with a blood concentration of 2.5+/-0.4 mug/ml practolol and 0.10+/-0.08 mug/ml propranolol. The antagonist activities of these drugs against adrenergic stimulation with isoproterenol infusion indicated a much greater relative potency of propranolol against this stimulus, and in vivo estimates of PA(2) values differed by more than 600-fold. Relative antagonist activity of practolol during isoproterenol stimulation was equivalent both at cardiac (inotropic and chronotropic) and at vascular adrenergic receptors, whereas greater antagonist activity of propranolol was observed at vascular receptors than at cardiac receptors. Thus, the activity of practolol was not limited to cardiac receptors as previously suggested. Practolol did not reduce cardiac output at any dose level and the effect on resting blood pressure was small. Both practolol and propranolol had much greater hypotensive activity during exercise. These studies have defined the differing pharmacodynamic activities on the cardiovascular system of two effective beta adrenergic receptor antagonists and have established the blood levels of these antagonists necessary to achieve effective adrenergic blockade.


Teaching medical assistants for the doctor.


Neurologic manifestations of conductive--tissue disease.


Effects of radiation on hematopoietic tissue.


Temperature-dependent reaction of flufenamic acid with rat erythrocyte membrane.


Strain differences in the ability of antithymocyte serum (ATS) to enhance the antibody response of inbred mice to type 3 pneumococcal polysaccharide.


Age-related pathologic changes, hypertension, and 18-hydroxydeoxycorticosterone in rats selectively bred for high or low juxtaglomerular granularity.


The training of physician's assistants. The use of a clinical algorithm system for patient care, audit of performance and education.


An abnormality of the alternate pathway of complement activation in sickle-cell disease.


Algorithms, anyone?

Algorithms, anyone?


Sickle-cell disease and the properdin system.


The effect of anions on the oxidase activity of rat ceruloplasmin.


Quantification of human seminiferous epithelium. 3. Histological studies in 44 infertile men with normal chromosome complements.


Drug-induced pulmonary disease.

Drug-induced pulmonary disease.


Effect of practolol on the extent of myocardial ischaemic injury after experimental coronary occlusion and its effects of ventricular function in the normal and ischaemic heart.


Cardiospecificity of  -receptor blockade. A comparison of the relative potencies on cardiac and peripheral vascular  -adrenoceptors of propranolol, of practolol and its ortho-substituted isomer, and of oxprenolol and its para-substituted isomer.


Corticosteroid-sparing effect of  -adrenergic blocking agents in pemphigus vulgaris.


Initiation of aerobic oxidation of sulfite by illuminated spinach chloroplasts.


Mechanism of enzymatic reduction of steroid double bonds.


Nucleus-associated 5 -reductase activity in the rat.


Interaction of the central nervous system with the endocrine system in thermoregulation in baboons.


Studies of aqueous humor dynamics in man. 3. Measurements in young normal subjects using norepinephrine and isoproterenol.


Structural factors influencing outflow facility and its changeability under drugs. A study in Macaca arctoides.


Behavioral correlates for the Minnesota Multiphasic Personality Inventory 4-9, 9-4 code types: a case of the emperor's new clothes?


Behavior setting utilization by emotionally disturbed college students.


A comparison of defectors and continuers in a child guidance clinic.


The certifying of physicians' assistants.


Effects of cannabis and alcohol on psychological tests.


2-Nitrilophenoxypropanolamines:  -adrenoreceptor antagonism in the rat.


Pharmacological studies on 1-(7-indenyloxy)-3-isopropylaminopropan-2-Ol hydrochloride (YB-2), a new  -adrenergic blocking agent.


Electrophysiological evaluation of anesthetic actions of some beta-adrenergic blockers on guinea-pig cardiac muscles.


Mechanism studies of gastric inhibition by glucagon: failure of KCl and adrenergic blocking agents to prevent its action.


Facial sweating after food: a new sign of diabetic autonomic neuropathy. Facial sweating during eating (gustatory sweating) has been observed for the first time in a group of diabetics, and is considered to be a feature of the autonomic neuropathy which affected them all. The sweating, which was sometimes very severe, was produced by many foodstuffs, cheese being the most powerful stimulus. Atropine inhibited sweating stimulated by eating cheese, and oral anticholinergic drugs effectively eliminated the symptoms. These bizarre symptoms are probably due to abnormal nerve regeneration occurring as a consequence of the spontaneous autonomic neuropathy.


Cytological study of the gut cells of the larvae of mosquito vectors.


Familial occurrence of persistent Mullerian structures in otherwise normal males. Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.


Bender-Gestalt constriction as an indicator of depression in psychiatric patients.


MMPI correlates with locus of control in a psychiatric population.


Clinical judgment: the effects of statistical information.


Nocturnal man-biting mosquitoes of urban and rural areas.


Localised histoplasmosis treated with amphotericin.


Mesenteric vascular insufficiency. Identification and management.


Viral encephalitis.

Viral encephalitis.


Modern functional morphology of the equine lung.


Regulation of oxalacetate metabolism in liver mitochondria. Evidence for nicotinamide adenine dinucleotide-malate dehydrogenase equilibrium and the role of phosphoenolpyruvate carboxykinase in the control of oxalacetate metabolism in intact guinea pig and rat liver mitochondria.


The effects of cycloheximide on energy transfer in rat and guinea pig liver mitochondria.


Inhibition of induction of rat liver tyrosine aminotransferase by D-galactosamine.


Intranuclear binding of 17 -estradiol and estrone in female ovine pituitaries following incubation with estrone sulfate.


Spasmolytic effect of polysorbates (Tweens) 80 and 20 isolated tissues.


A mechanism for the regulation of nicotinamide adenine dinucleotide-linked substrate oxidation in rat liver mitochondria.


Nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate-specific glucose 6-phosphate dehydrogenases of Acetobacter xylinum and their role in the regulation of the pentose cycle.


Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-8n-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine.


Biosynthesis of bacterial glycogen. XI. Kinetic characterization of an altered adenosine diphosphate-glucose synthase from a "glycogen-excess" mutant of Escherichia coli B.


Contact inhibition and gene expression in HTC-L cell hybrid lines.


Evidence for similar biochemical requirements for bioluminescence among the coelenterates.


Effects of neurotransmitters on the hepatic blood flow in dogs.


The training and role of physicians' assistants in the Army Medical Department.


Effect of immunosuppressive drugs on a localized graft-versus-host reaction in the rat.


On the enzymology of amino acid transport.


Familial hyperparathyroidism. Mild hypercalcemia in at least nine members of a kindred.


What one internist does in his practice. Implications for the internist's disputed role and education.


Effect of stellate ganglion stimulation on myocardial blood flow, oxygen consumption, and cardiac efficiency during beta-adrenoceptor blockade.


Cellular immunity and blocking serum activity in chimeric mice.


Revamping the health care team.

Revamping the health care team.


Artificial testicles in children: a new silastic gel testicular prosthesis.


Menaquinone function in the electron transport system of an antibiotic-producing strain of Bacillus brevis.


Assessment of the radioprotective capacity of spleen cells transplanted from mice with Rauscher viral leukemia.


Prevalence of neoplasms and causes of death in paralysis agitans. A necropsy study.


The role of amine mechanisms in the vasomotor regulation of intracranial arteries.


The development of new antidysrhythmic drugs.


Emetic effect of biogenic amines.

Emetic effect of biogenic amines.


Clinical assessment of practolol in coronary heart disease.


Excretion of catecholamines, corticosteroids and 5-HIAA as related to the testing conditions, physical fitness and psychological variable of healthy sunjects.


Analysis of the hemodynamic action of beta-adrenolytics in narcotized cats.


Methodological issues in measuring ambulatory care.


Insulin and Sepharose-insulin effects on tyrosine transaminase levels in cultured rat liver cells.


Effect of some adrenergic beta-receptor antagonists on the act ion of d-tubocurarine and pancuronium bromide.


The relationship of personality to tolerance of an irritant compound.


The physician's assistant in a psychiatric hospital.


Synthesis of some 4-substituted amino-1-methylpiperidines structurally related to antihistaminics.


Nymphomania--a symptom. II. Psychoses.

Nymphomania--a symptom. II. Psychoses.


Gastric mucosal damage induced by non-steroid anti-inflammatory agents in rats of different ages.


Practolol in patients with angina pectoris.


Effects of practolol on pressor responses to noxious stimuli in hypertensive patients.


Steroids. XX. Non-specific enzymic hydroxylation of aromatic steroids. 19. In vitro hydroxylation and transformations.


Influence of isolation and of fighting on adrenal tyrosine hydroxylase and phenylethanolamine-N-methyltransferase activities in three strains of mice.


Assays of tissual NADP by means of the recycling system composed of isocitrate dehydrogenase and glutathione reductase.


Enhancement by cystamine of formation of thiols by liver cytoplasmic enzymes.


Long-term immunosuppressive therapy of ulcerative colitis. Continuation of a personal series.


Acquired resistance to beta stimulants: a possible explantion for the rise in the asthma death rate in Britain.


In vivo and in vitro studies on alpha-receptors in human airways; potentiation with bacterial endotoxins.


Effects of practolol on respiratory and cardiovascular responses to isoproterenol in normal and asthmatic subjects.


Gas-liquid chromatography of phenothiazine derivatives and related compounds.


Renal abnormalities in the Russell-Silver syndrome.


Electrophoretic variation in glutamate dehydrogenase and other isozymes in wild carrot cells cultured in the presence and absence of 2,4-dichlorophenoxyacetic acid.


Hyperdibasicaminoaciduria in a mentally retarded homozygote with a peculiar response to phenothiazines.


Antihistamines in topical preparations.

Antihistamines in topical preparations.


Cryptorchidism in the newborn.

Cryptorchidism in the newborn.


Functional properties of segregated lymphocytes.


Diversity of T cells recognizing transplantation antigens: mechanism of antigen recognition.


Characteristics of histocompatibility barriers in congenic mice.


Immune responsiveness and active enhancement of rat renal allografts with soluble specific antigen.


The reactivity of blood lymphocytes from actively enhanced rats.


The cellular basis of transplantation tolerance.


Specific immunosuppression of cardiac allograft rejection in rats.


Tolerance reconsidered--a critical survey.


Transplantation of neonate thymus-sternum complex in ataxia-teleangiectasia.


Specific depletion of GVH reactivity of mouse lymphocytes by adsorption on allogeneic fibroblast monolayers.


Inhibition of allograft reactivity in vitro and in vivo, by Fab fragments obtained from ALG.


Prevention of graft-versus-host disease by Fab fragments derived from ALG.


Specific inactivation of lymphoid cells in bone marrow grafts.


Recent advances in transplantation of incompatible marrow in infants with combined immunodeficiency disease.


Immunologic reconstitution in severe combined immunodeficiency with HL-A-incompatible bone marrow graft: donor selection by mixed lymphocyte culture.


Aplastic anemia treated by marrow transplantation.


The use of stem cell concentrates as bone marrow grafts in man.


Marrow grafting in patients with acute leukemia.


Progress in the prevention of GVH: bone marrow grafts after ALG conditioning, with lymphocyte split chimerism, use of a lymphocyte "chalone T", and soluble histocompatibility antigens.


Viral etiology of immunologically induced lymphomas.


Vitamin E protection of membrane lipids during electron transport functions.


Thymic carcinoid in familial multiple endocrine adenomatosis.


Transamination of ring-substituted L-phenylalanines by an extract from rat liver mitochondria.


Enzyme activities during culturing of fetal rat liver.


Photoperiodism in Orthopodomyia signifera.


Comparison of therapeutic and toxic actions of ouabain, gitoxin and 16-epi-gitoxin on isolated atria at different extracellular potassium concentrations.


Effects of adrenergic blockers on the relaxation of the guinea-pig ileum by bradykinin and adrenaline.


Central cardiovascular effects of intracerebroventricular propranolol.


Effect of   9 -tetrahydrocannabinol on immobilization-induced changes in rat adrenal medullary enzymes.


Two-substituted aminomethylquinolines & 1,2,3,4-tetrahydroquinolines & 3-substituted 2,3,4,4a,5,6-hexahydro(1-H) pyrazino(1,2-a)quinolines--a new class of alpha-adrenoceptor blocking agents.


The Institute of Hospital Dental Service.


National Dental Health Conference explores peer review, manpower planning, responsibility of consumers. Council on Dental Health, Council on Dental Care Programs.


Visual test for erythrocytic glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase, and glutathione reductase deficiencies.


Quellung test for pneumonia.

Quellung test for pneumonia.


Liver enlargement and modification of hepatic microsomal drug metabolism in rats by pyrethrum.


Dysrhythmias during inhalational anaesthesia for oral surgery. Incidence and prevention and treatment with practolol.


Anaesthesia for liver transplantation in primates.


Beta-blockade and left ventricular performance under halothane anesthesia.


Combination chemotherapy for clinically established graft-versus-host disease in mice.


Comparative inhibition studies of the phosphotransferase and glycerophosphate acylation systems in membrane vesicles of Escherichia coli.


Histochemistry of succinate dehydrogenase, glucose-6-phosphate dehydrogenase and NADPH tetrazolium reductase in human skin. I. Post-mortem variations and effects of autolysis, and histotopography.


Histochemistry of succinate dehydrogenase, glucose-6-phosphate dehydrogenase and NADPH tetrazolium reductase in human skin. II. Regional differences in histochemical activity.


Intravenous infusion of salbutamol in the management of premature labour.


Biochemical cytology of trichomonad flagellates. I. Subcellular localization of hydrolases, dehydrogenases, and catalase in Tritrichomonas foetus. To determine the localization of several enzymes in Tritrichomonas foetus, the axenic KV-1 strain was grown in Diamond's medium with bovine serum, homogenized in 0.25 M sucrose, and subjected to analytical differential and isopycnic centrifugation. The fractions were assayed for their enzymatic composition and examined electron microscopically. NADH and NADPH dehydrogenases, about 90% of the catalase, and two hydrolases, alpha-galactosidase and manganese-activated beta-galactosidase I are in the nonsedimentable part of the cytoplasm. alpha-Glycerophosphate and malate dehydrogenases are associated with a large particle, whose equilibrium density in sucrose gradients is 1.24. This particle corresponds to that population of the paracostal and paraxostylar granules which, having a uniform granular matrix surrounded by a single membrane, resemble microbodies from other organisms. The small sedimentable portion of catalase (about 10% of the total activity) is not associated with these granules and equilibrates at density 1.22. The nature of the subcellular entity carrying catalase could not be ascertained. Hydrolases with a pH optimum around 6-6.5 (protease, beta-N-acetylglucosaminidase, beta-N-acetylgalactosaminidase, and cation-independent beta-galactosidase II), as well as a large part of acid phosphatase, are associated with a population of large particles which equilibrate at densities from 1.15 to 1.20. The hydrolases in these granules lose their structure-bound latency easily after freezing and thawing. These particles correspond to another population of the paracostal and paraxostylar granules which have varied shape and inhomogeneous content with frequent myelin figures, indicating a digestive function. The rest of the phosphatase and most of the acid beta-glucuronidase activity are in a smaller granule fraction with an equilibrium density around 1.18. The latency of these enzymes is quite resistant to freezing and thawing. This particle population consists of smaller, very often flattened vesicles and granules, many of which are clearly fragments of the prominent Golgi apparatus of the cell.


Pharmacological studies of two new cardioselective adrenergic beta-receptor antagonists.


Isolated hormone receptors: physiologic and clinical implications.


Thermal properties of the collagen of jellyfish (Aurella coerulea) and their relation to its thermal behaviour.


Influence of electron transport on the interaction between membrane lipids and Triton X-100 in Halobacterium cutirubrum.


Introduction to IUPS Satellite Symposium (Gyllenberg-Symposium), Helsinki, Finland, August 2-3, 1971. 'Information transfer from a neurophysiological and neurochemical point of view'.


A mosquito parasite from a mosquito predator.


Changes in the constitutive enzymes of chick cells following infection with Semliki Forest virus.


A canonical-correlation analysis of 16 fear factors and the MMPI.


Polyarteritis.

Polyarteritis.


Brain amine and adrenal enzyme levels in aggressive, bulbectomized rats.


Two models of the partially focused clear zone compound eye.


Carbohydrate transport by micro-organisms.


The role of lymphocytes in antibody formation. V. Transfer of immunological memory to tetanus toxoid: the origin of plasma cells from small lymphocytes, stimulation of memory cells in vitro and the persistence of memory after cell-transfer.


The dioptric system of the eye of Cybister (Dytiscidae: Coleoptera).


MMPI personality patterns of alcoholics and narcotic addicts.


Wives of alcoholics. A critical review and analysis.


The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment. A double-blind trial on patients asymptomatic for one year.


Relationship between cyclic AMP, phosphodiesterase activity, calcium and contraction in intestinal smooth muscle.


Interaction between the fastigial pressor response and the defence reaction.


Alcohol dehydrogenase activity in Rhodotorula glutinis.


Chemical facilitation in dynamic models of neural macrostates.


Effects of an hyperoxic hypobaric environment on renin-aldosterone in normal man.


Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents.


Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase.


Prelycopersene pyrophosphate and lycopersene. Intermediates in carotene biosynthesis.


Enzymatic oxidation of nicotine to nicotine   1'(5')  iminium ion. A newly discovered intermediate in the metabolism of nicotine.


Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. II. Identification of a new class of heme prosthetic group: an iron-tetrahydroporphyrin (isobacteriochlorin type) with eight carboxylic acid groups.


Characterization of an adrenal activator for cholesterol side chain cleavage.


Lumisomes, the cellular site of bioluminescence in coelenterates.


A comparative study of growth and development in Florida mosquitoes. 4. Effects of temporary crowding during larval stages on female flight activity patterns.


Factors affecting mass production of Reesimermis nielseni, a nematode parasite of mosquitoes.


The mosquito fauna of Sinai.

The mosquito fauna of Sinai.


Drug-induced extrapyramidal symptoms. A cooperative study.


Medical aspects of diving. 2.

Medical aspects of diving. 2.


Evidence from electron microscope studies on actin paracrystals concerning the origin of the cross-striation in the thin filaments of vertebrate skeletal muscle.


The influx of amino acids into the brain of the rat in vivo: the essential compared with some non-essential amino acids.


A note suggesting that the cross-bridge attachment during muscle contraction may take place in two stages.


The transport of glucose into the brain of the rat in vivo.


Instructions, word association, and the hospitalized psychiatric patient.


Meeting of the sub-committee of the FAO-OIE-OAU expert panel on contagious bovine pleuropneumonia.


Cyclic AMP and intestinal glycoprotein synthesis: the effect of  -adrenergic agents, theophylline, and dibutyryl cyclic AMP.


Evaluation of a new B 2  adrenergic receptor stimulant, terbutaline, in bronchial asthma. I. Subcutaneous comparison with epinephrine.


Evaluation of a new B 2  adrenergic receptor stimulant, terbutaline, in bronchial asthma. II. Oral comparison with ephedrine.


A comparative analysis of the ontogenic development of rat liver sequential enzymes-tyrosine  -ketoglutarate aminotransferase, p-hydroxyphenylpyruvate hydroxylase, and homogenitsate oxygenase.


Drug addiction and the newborn.

Drug addiction and the newborn.


Antigen-induced depression of DNA synthesis in mouse spleen.


Development of adrenergic neurons in vivo: inhibition by ganglionic blockade.


Hydroxylation and biogenic amine synthesis in the human fetus.


Tyrosine hydroxylase activity in rat brain following "REM" sleep deprivation.


Energetics of growth in a tyrothricin-producing strain of Bacillus brevis.


The multimeric nature of NADPH-nitrate reductase from Aspergillus nidulans.


Stimulants for insomnia.

Stimulants for insomnia.


Progress in anxiety states.

Progress in anxiety states.


Effects of halothane on the cyclic 3',5'-adenosine monophosphate (cyclic AMP) system in rat uterine muscle.


Partial hypogonadotrophic hypogonadism: studies of pituitary function and of the pituitary-testicular relationship in two patients.


Uptake and release of  -aminobutyric acid (GABA) in slices of substantia nigra of rat.


Kinetic and enzymatic features of metabolic stimulation of alveolar and peritoneal macrophages challenged with bacteria.


Comparison of new  -andrenergic blockers, C-3, Kö1366, Y-6124 and YB-2, with pindolol and propranolol in the blood perfused canine papillary muscle preparation.


10-Methoxyergoline derivatives as  -adrenergic blocking agents.


Comparison of  -adrenergic blocking activity of eight blockers in the excised and blood-perfused canine sino-atrial node preparation.


Competence for deoxyribonucleic acid uptake and deoxyribonuclease action external to cells in the genetic transformation of Diplococcus pneumoniae. A mutant of Diplococcus pneumoniae that apparently does not require activator can become competent for uptake of deoxyribonucleic acid (DNA) when grown in dilute cultures or in the presence of trypsin. Development of competence in both mutant and wild strains is temperature dependent, being 10-fold greater at 30 C than at 37 C. Induction of competence on a shift from 37 to 30 C requires protein synthesis and the presence of Mg(2+) and Ca(2+); uptake of DNA does not require protein synthesis. Competence decays exponentially at higher temperatures. As well as taking up DNA, competent cells release oligonucleotide fragments of donor DNA in the medium external to the cells. Normal strains release fragments comparable in amount to the DNA taken up; but, in a mutant selected for inability to degrade DNA in agar, the amount of fragments formed external to the cells is only 40% of DNA uptake. Requirements for external deoxyribonuclease action are identical to those for DNA uptake: prior development of competence and the presence during treatment with DNA of Mg(2+) ions and a source of energy.


Pyridine nucleotide-dependent glucose dehydrogenase activity in blue-green algae. Pyridine nucleotide-dependent glucose dehydrogenase activity (GPND) is described for the first time in cell-free extracts of certain blue-green algae. When glucose is added to these crude cell extracts, nicotinamide adenine dinucleotide phosphate is reduced at twice the rate as nicotinamide adenine dinucleotide; but evidence suggests that this activity is due to a single enzyme. The distribution and level of GPND in selected blue-green algae correlates with the heterotrophic potential of each species. In all blue-green algae where GPND was detected, O(2) uptake coupled to the GPND reaction was also observed. Both GPND and O(2) uptake apparently occur in the soluble fraction of the cell. An essential role for GPND in the heterotrophic metabolism of blue-green algae is postulated.


Genetic analysis of ribonucleic acid polymerase mutants of Bacillus subtilis. Deoxyribonucleic acid-dependent ribonucleic acid polymerase mutants of Bacillus subtilis strain Marburg were isolated after mutagenesis of spores with ethyl methane sulfonate. Genetic analysis by PBS1-mediated transduction and by transformation indicated that mutations responsible for all of the four phenotypic classes studied (rifampin resistance, streptovaricin resistance, streptolydigin resistance, and temperature sensitivity) were clustered close to the cysA14 locus. Three-factor transformation analysis has indicated the most probable marker order as follows: Rif(R)(Stv)(R)-Std(R)-Ts(418)-Ts(427). In addition, further characterization of the classical group I reference marker, cysA14, is reported.


Rat brain tyrosine hydroxylase. Activation by limited tryptic proteolysis.


Catecholamine metabolism in tissue culture cells of a neuroblastoma.


Subcellular distribution of isocitrate dehydrogenases in neonatal and adult mouse brain.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. 28. The reconstitution of the first site of energy conservation.


Isoenzymes of  -glutamyl transpeptidase in liver diseases.


Reflex responses to stimulation of the upper respiratory tract.


Cell-mediated immunity after thermal injury.


Immunosuppression and neoplasia. II. Is deficient immunesurveillance the only mechanism by which immunosuppression promotes neoplasia? A speculative review.


Man and his environment.

Man and his environment.


A vasectomy prosthesis.

A vasectomy prosthesis.


Nocardia--streptomyces infection of the foot.


Perforation of the colon in the neonate.


Pituitary apoplexy.

Pituitary apoplexy.


Concepts of management in infertility.

Concepts of management in infertility.


Traumatic visceral pseudoaneurysms.

Traumatic visceral pseudoaneurysms.


Pneumococcal arthritis: report of a case and review of the literature.


Immunologic studies on resistance to oncogenic agents in mice.


Amino-acid sequence homologies between the NADP-dependent glutamate dehydrogenase of Neurospora and the bovine enzyme.


Extracorporeal animal liver perfusion in patients in hepatic coma: anesthesiological problems.


Polyarteritis nodosa and pregnancy: report of a successful outcome.


Eosinophilic lung disease (or how to slice P.I.E.).


An isotopic assay of cyclic 3',5'-nucleotide phosphodiesterase with aluminum oxide columns.


A microwell assay method for the biochemical study of cultured cells.


Amylase and acid phosphatase in unstimulated human parotid fluid.


Tolerance and side effects during long term treatment of hypertension with debrisoquine.


Phaeochromocytoma with catecholamine cardiomyopathy successfully treated surgically.


Phenothiazines and jaundice.

Phenothiazines and jaundice.


Histochemical demonstration of enzymes in the uropygial gland of the fowl.


The influence of lipophilicity on the antibacterial activity of rifamycins.


An attempt to identify putative neurotransmitter molecules in the central nervous system of the snail.


The homeostatic nursing care plan.

The homeostatic nursing care plan.


Endoplasmic reticulum as the site of lecithin formation in castor bean endosperm. The properties of a discrete membranous fraction isolated on sucrose gradients from castor bean endosperm have been examined. This fraction was previously shown to be the exclusive site of phosphorylcholine-glyceride transferase. The distribution of NADPH-cytochrome c reductase and antimycin insensitive NADH-cytochrome c reductase across the gradient followed closely that of the phosphorylcholine-glyceride transferase. This fraction also had NADH diaphorase activity and contained cytochromes b(5) and P 450. On sucrose gradients containing 1 mM EDTA this fraction had a mean isopycnic density of 1.12 g/cm(3) and sedimented separately from the ribosomes; electron micrographs showed that it was comprised of smooth membranes. When magnesium was included in the gradients to prevent the dissociation of membrane-bound ribosomes, the isopycnic density of the membrane fraction with its associated enzymes was increased to 1.16 g/cm(3) and under these conditions the electron micrographs showed that the membranes had the typical appearance of rough endoplasmic reticulum. Together these data show that the endoplasmic reticulum is the exclusive site of lecithin formation in the castor bean endosperm and establish a central role for this cytoplasmic component in the biogenesis of cell membranes.


The use of simulation with students having a community health nursing experience.


The beginnings of nursing education in the United States: an analysis of the times.


Competencies of nursing directors in junior colleges.


Small interactional groups in the psychiatric training of graduate nursing students.


Opsonins: their function, identity, and clinical significance.


Effects of antihistamine-epinephrine combinations on adjuvant arthritis in rats.


Dimethylformamide dimethylacetal as a derivatizing agent for GLC of barbiturates and related compounds.


Burned feet in children. Acute and reconstructive care.


Urinary steroid patterns after short and long term treatment with human chorionic gonadotropin (HCG) of prepubertal boys with undescended testes.


Use of technetium ( 99m Tc) as a bacterial label in lung clearance studies. The suitability of technetium ((99m)Tc), a gamma emitter, for labeling of Diplococcus pneumoniae in studies of lung bacterial clearance was examined. A killed bacterial slurry with high specific activity was obtained with a ferric ascorbate reducing system. Approximately 5.5% of radioactive counts dissociated from labeled bacteria in 6 h. Rats were exposed to a uniformly mixed aerosol of untagged, viable pneumococci and killed, (99m)Tc-tagged pneumococci. The aerodynamic behavior of labeled and unlabeled pneumococci was similar. Viable bacterial counts and radioactive counts were determined in lung homogenates at intervals following exposure, and rates of bacterial killing and disappearance of radioactive counts were plotted. Radioactive counts did not increase in the liver during the period of observation, suggesting that the decrease in lung radioactivity represents mucociliary clearance and not release of isotope to the systemic circulation. The use of (99m)Tc for bacterial labeling provides advantages of technical simplicity and personnel safety compared to the use of beta-emitting isotopes.


Effect of osmotic stabilizers on  14 CO 2  production by bacteria and blood. Evolution of (14)CO(2) by whole blood as well as by Diplococcus pneumoniae, Haemophilus sp., Pseudomonas aeruginosa, Pseudomonas diminuta, and Streptococcus pyogenes was examined by using the BACTEC system. The control medium was JLI no. 6A culture vial containing 30 ml of enriched tryptic soy broth and 1.5 muCi of (14)C-substrate. Hypertonic media consisted of control medium with either 1 or 3% NaCl, 10% sucrose, and 5%, 10%, or 15% dextran. The most deleterious treatment to bacteria was 3% NaCl since it not only retarded (14)CO(2) production, but also prevented growth of D. pneumoniae, Haemophilus, and P. diminuta. The 10% sucrose treatment diminished (14)CO(2) output, although it did not retard growth of test organisms. This effect was probably due to (14)C-substrate dilution rather than to osmotic effects. Dextran had slight effect on (14)CO(2) production and slightly acidified the medium. Of the treatments tested, only 10% sucrose reduced normal output of (14)CO(2) by whole blood. This also is probably due to (14)C-substrate dilution. It appears that 10% sucrose is potentially the most useful osmotic agent for radiometric techniques since, although bacterial (14)CO(2) production is lowered, blood (14)CO(2) is lowered also.


Properties of homoserine dehydrogenase in a thermophilic bacterium.


Studies of a halophilic NADH dehydrogenase. I. Purification and properties of the enzyme.


Activation of guanyl cyclase and adenyl cyclase by secretin.


Introductory address presented at the Sixth Conference of European Comparative Endocrinologists, Montpellier, 1971. General aspects and problems in comparative endocrinology.


Histological and histochemical findings in muscle spindles in dystrophia myotonica.


Structural changes in myosin in dystrophic, denervated and regenerating muscle in mice.


Prevalence of rheumatic disease.

Prevalence of rheumatic disease.


Necrotizing arteritis and other forms of vasculitis.


Basal level of neurotransmitter synthesizing enzymes and effect of cyclic AMP agents on the morphological differentiation of isolated neuroblastoma clones.


Haemolytic phospholipase A and nerve-affecting activities of sea anemone nematocyst venom.


Bacterial endocarditis in x-irradiated rats: effect of isoproterenol and adrenergic receptor blocking agents.


Effect of tyrosine hydroxylase inhibition on the action of 6-hydroxydopamine.


Pathogenesis of the graft-versus-host reaction in chicken embryos. The development of haemorrhagic lesions.


Duration of action of beta-blocking drugs.


Serum gamma glutamyl transpeptidase in liver disorders.


Enzymatic histone modification during the induction of tyrosine aminotransferase with insulin and hydrocortisone.


Effect of prostaglandin E 1  on cellular and humoral immune responses.


Suicide attempt with practolol.

Suicide attempt with practolol.


Noonan's syndrome and cryptorchidism.

Noonan's syndrome and cryptorchidism.


Excretory urography in asymptomatic boys with cryptorchidism.


Action of acetylcholine on the longitudinal muscle of guinea-pig ileum: the role of an electrogenic sodium pump.


A contribution to the mechanism of drug inhibition of the graft vs host reaction.


The action of catecholamines on guinea-pig taenia coli.


The nervous release and the action of substances which affect intestinal muscle through neither adrenoreceptors nor cholinoreceptors.


Adrenergic influences on uterine smooth muscle.


The stimulant action of acetylcholine and catecholamines on the uterus.


The mechanism of contraction.

The mechanism of contraction.


A discussion on recent developments in vertebrate smooth muscle physiology. A survey of new findings and the discussions arising during sessions I. II and 3.


Sarcoplasmic reticulum and mitochondria as cation accumulation sites in smooth muscle.


The subunit structure of gizzard myosin.


The structure of the myosin elements in vertebrate smooth muscles.


The influence of temperature on the thick filaments of vertebrate smooth muscle.


Smooth muscle: contraction hypothesis based on the arrangement of actin and myosin filaments in different states of contraction.


The assembly of ribbon-shaped structures in low ionic strength extracts obtained from vertebrate smooth muscle.


The site and state of myosin in intestinal smooth muscle.


Filament organization in vertebrate smooth muscle.


A discussion on recent developments in vertebrate smooth muscle physiology: concluding remarks.


Ion distribution and the role of calcium in cellular function. Ion distribution and ion movements in smooth muscle.


Structure and electrical properties of the autonomic neuromuscular junction.


Smooth muscle physiology, past and future.


Active ion transport and resting potential in smooth muscle cells.


Factors controlling cytoplasmic Ca 2+  concentration.


Factors controlling myogenic activity in smooth muscle.


Cellular structures and electrophysiological behaviour. Fine structure of smooth muscle.


Na-Ca exchange and tension development in arterial smooth muscle.


The mechanisms of action of neurotransmitters. Electrical changes underlying excitation and inhibition in intestinal and related smooth muscle.


Effect of iron and calcium on salicylazosulphapyridine metabolism.


Profound sensorineural hearing loss associated with collagen disease.


Piperacetazine and chlorpromazine: a comparison.


-adrenergic blocking and cardiovascular properties of a new compound, 1-(7-indenyloxy)-3-isopropylaminopropan-2-ol-hydrochloride (YB-2).


Some pharmacological effects of centrophenoxine and its components in mice.


The management of depression in consultant medical practice.


Studies on the inhibition of glutamine synthetase by methionine sulfone.


Inhibition by serotonin of glutamine synthetase formation in cultured mouse cells strain L.


Beta-blockade of epinephrine-induced cyclic AMP formation in heart, liver, fat and trachea.


Control of cyclic AMP levels in isolated fat cells from hamsters.


A device for the self-marking of mosquitos. The authors describe a simple device for marking emergent adult mosquitos with fluorescent dye. This technique is of value in the study of the dynamics of insect populations.


Haematology and biochemistry of ankylosing spondylitis. Forty men with ankylosing spondylitis have been reviewed clinically, radiologically, haematologically, and biochemically, and the results of the last two compared with a male group of rheumatoid patients and a control group. In the patients with ankylosing spondylitis the haemoglobin levels were much higher and the E.S.R. significantly lower than in the rheumatoid group, and the E.S.R. in the patients with ankylosing spondylitis was unrelated to disease activity as evidenced by pain. The alkaline phosphatase level was raised in 19 cases and in most was derived from bone. Though 10 patients had abnormal globulin levels, the albumin levels were normal, as was renal function in all cases.


Bacterial resistance: changing patterns of some common pathogens.


Properties of hepatic hexose-6-phosphate dehydrogenase purified from brook trout and lake trout.


Enzymatic activities of venom from the jellyfish Stomolophus meleagris.


Regulation of gene function: a comparison of X-linked enzyme activity levels in normal and intersexual triploids of Drosophila melanogaster. We have measured gene function in normal and male-like intersexual triploids of Drosophila melanogaster by assaying crude extracts of whole flies or thoraces for levels of an X-linked (6-phosphogluconate dehydrogenase) and an autosomal (NADP-dependent isocitrate dehydrogenase) enzyme activity. Our observations lead us to conclude that each dose of the X-linked gene is more active in the cells of these intersexes than it is in normal triploid or diploid female cells. These results indicate that a level of activity intermediate between the normal male and female levels is possible for X-linked genes.


When postural hypotension signals disease.


Psychological adjustment--mood and personality fluctuations of long-term methadone maintenance patients.


Dihydrofolate reductase and aminopterin resistance in Pneumococcus.


Surgery of the male genital tract in cattle: a review of 121 cases.


A simple radioisotope assay for microsomal aryl hydroxylase.


The preparation of stereospecific tritium-labeled reduced nicotinamide adenine dinucleotide phosphate.


Differences in the redox balance in human rheumatoid and non-rheumatoid synovial lining cells.


The effects of early experimental cryptorchidism and subsequent orchidopexy on the maturation of the guinea-pig testicle.


The effect of unilateral experimental cryptorchidism and subsequent orchidopexy upon maturation of the contralateral scrotal testicle of the guinea-pig.


Structural features inhibiting the cross-reaction of the acidic polysaccharide from Tremella mesenterica with a type II anti-pneumococcal serum.


Fatty acid synthetase from Pythium debaryanum.


Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium.


Studies on the kinetics and regulation of glutamate dehydrogenase of Salmonella typhimurium.


Isocitrate supported nitrogenase activity in Gloeocapsa sp. LB 795.


The development of the immune response to type 3 pneumococcal polysaccharide in chickens.


A study of the role of allocluster-forming cells in the graft-versus-host reaction in chickens.


Studies on isocitrate lyase from the facultative autotroph Thiobacillus novellus.


Symposium on gastrooesophageal reflux and its complications. 4. Pharmacology and therapeutics.


Gastric and intestinal transit in rats measured by a radioactive test meal.


The regulation of rat liver calciferol-25-hydroxylase.


Resistance of microsomes from CCl 4 -ccirrhotic rat liver to lipoperoxidation activity.


Post-transcriptional inhibition of protein synthesis by rifampicin in rat hepatoma cells.


The intermediate coronary syndrome: clinical, angiographic and therapeutic aspects.


Drug therapy. Anticholinergics.

Drug therapy. Anticholinergics.


Circadian rhythms in neurospora: spatial differences in pyridine nucleotide levels. A growing colony of a mutant strain of Neurospora crassa had two morphologically distinct areas which were formed as a result of a rhythmic spore-forming (conidiation) process. The total pyridine nucleotide content of these two areas was the same, but the levels of NADH, NADPH, and NADP were lower in the conidiating area, while the NAD level was higher. These biochemical differences in the adjacent areas of a single colony were only found in newly formed areas, and were not a permanent record. It is not known whether these pyridine nucleotide changes are a result of the conidiation process, or whether they are tied more directly to some underlying metabolic oscillation. However, it is speculated that the changes in the levels of these key coenzymes could have far-reaching effects on many areas of metabolism.


The effect of some cytostatics on tyrosine aminotransferase activity in rat liver.


Experimental metastasizing in syngeneic and autochthonous tumour-host systems.


An ultrastructural comparison of peripheral nerve allografts and autografts.


Adrenergic mechanisms in the canine ureter.


Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle.


Norepinephrine-responsive beta-adrenergic receptors in rabbit lacrimal gland.


The development of health services for mothers and children in the United States.


Stimulation of pentose cycle in the eccrine sweat gland by adrenergic drugs.


The in vitro activity of peritoneal exudate cells of NZB-B1 and BALB-C mice following intraperitoneal injection of spleen cells from diseased and "healthy" NZB-B1 and from old and young BALB-C mice.


Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration.


Peroxisomal enzymes in human granulocytes. II. D-aminoacid oxidases and L- -hydroxyacid oxidases.


Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulfapyridine (Azulfidine).


Colonic complications after renal transplantation.


Central nervous actions and screening methods of antidepressants.


Dental caries in 506 young Ontario adults.


Aminopeptidases of rat testis. II. Effects of puberty, cryptorchidism and cadmium chloride treatment.


Aminopeptidases of rat testis. 3. Activity of dipeptidyl aminopeptidases I and II in normal and experimental conditions.


Extrapulmonary manifestations of respiratory disease with emphasis on abnormal electron (redox) metabolism.


Therapy of bronchial asthma.

Therapy of bronchial asthma.


Tetraphenylboron as direct titrant for diphasic determination of some organic bases.


Reproduction of Semliki Forest virus in poikilothermic and homeothermic cells at reduced temperatures.


Method for the purification and concentration of Vaccinia-virus.


Purification of smallpox vaccine with fluorocarbon.


The combined effect of polyamines and antibiotics against resistant strains of Staphylococcus aureus.


A study of staphylococci isolated from the upper respiratory tract of different animal species. V. Physiological properties of Staphylococcus aureus strains from mink.


Problems in immunology of human salmonellosis.


Bacteriocinogeny in Proteus-species.

Bacteriocinogeny in Proteus-species.


Studies on group A bacteriocins of Serratia marcescens: preliminary characterization of two subgroups of bacteriocins.


Immunochemical studies and differential diagnosis of Brucella infections in sheep.


The presence of Listeria monocytogenes in feces of pregnant women and neonates.


Enhancement of bacterial hemolysis by antibiotics.


Graft-versus-host reactions in mice. 3. Epithelioid and multinucleated giant cells of thymic origin. Thymus cells from C3H donor mice were infused into lethally irradiated (C3H x C57BL/10)F(1) hybrid mice. Light and electron microscopic examination of the lymphoid tissues of recipients revealed the presence of epithelioid and multinucleated giant cells in addition to lymphocytes and histiocytes. Serial transplantation of thymus-derived cells into irradiated F(1) hybrid mice resulted in a preponderance of epithelioid cells over lymphocytes. Epithelioid cells, as well as lymphocytes and histiocytes, incorporated (3)H-thymidine, indicating that they were actively proliferating. Following transplantation of CBA-T6T6 thymocytes into irradiated (C3H x C57BL/10)F(1) mice, karyotypic analysis of host lymphoid tissues indicated that all dividing cells were of donor origin. Whereas bone marrow is known to give rise to epithelioid cells in the absence of thymic influences, the thymus must also contain precursors of epithelioid cells.


Graft-versus-host reactions in mice. IV. Thymus cell suppression of antibody formation. The ability of transplanted marrow-thymus cell mixtures to generate antibody-forming cells in irradiated syngeneic or F(1) hybrid mice when immunized with sheep erythrocytes 18 hours later was determined. Much fewer anti-sheep plaque-forming cells (PFC) were detected in spleens of F(1) hybrid mice. Adrenalectomy, use of infant recipient mice, or preimmunization of donors or hosts did not prevent the suppression; the grafting of irradiated donor-type spleen cells (source of "accessory" cells) produced only an additive effect. Parental marrow and thymus cells were able to generate new precursors of PFC and specific inducer cells, respectively, in spleens of F(1) hybrid mice, as detected by two-step experiments utilizing parent-strain secondary recipient mice. The suppression depended upon transferring parental strain thymus cells into F(1) hybrid mice and was seen irrespective of the marrow donor strain. When irradiated mice were immunized twice (on the day of transplantation and 4 days later), there was only marginal suppression of antibody production when marrow cells only or marrow plus thymus cells were transplanted. Thus, it appears that an excess of thymus-derived "suppressor" cells is generated upon exposure to alloantigens and inhibit terminal differentiation of antibody-forming cells in a noncytotoxic manner. Mature PFC themselves were not the targets of suppression. The method of immunization probably determines the relative functional capacity of thymus-derived "helper" and suppressor cells.


Staffing the emergency department.

Staffing the emergency department.


The oral and physical health of students entering dental school.


Cardiac stimulant activity of the saponin of Achyranthes aspera (Linn).


Fluoride levels, fluorosis and dental caries: a study determining the optional level of fluoride from 15 communities.


Stimulation of tyrosine hydroxylase activity in an adrenergic clone of mouse neuroblastoma by dibutyryl cyclic AMP.


Interaction of aflatoxin B 1  metabolite with rat liver RNA.


The binding of phenothiazines to oxyhemoglobin A and S.


Effect of intravenous dibutyryl cyclic AMP on histamine-induced bronchospasm in the guinea pig.


Nurse education: the training of medical assistants in Rhodesia today.


The effect of repeated administration of (-)-  9 -tetrahydrocannabinol on the biosynthesis of brain amines.


Cardiovascular effects of fenoterol.

Cardiovascular effects of fenoterol.


Binding of  14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3  by reduced liver microsomes.


Cardiovascular effects of hexoprenaline sulphate and salbutamol in man.


Oxidative drug metabolism in the perinatal rabbit liver and placenta. A biochemical and morphologic study.


Association of pulmonary hypoplasia, renal anomalies, and Potter's facies.


Sarcoplasmic reticulum in Duchenne muscular dystrophy.


Diacetyl (acetoin) reductase from Aerobacter aerogenes. Kinetic mechanism and regulation by acetate of the reversible reduction of acetoin to 2,3-butanediol.


Adaptive changes in satellite systems related to lipogenesis in rat and sheep mammary gland and in adipose tissue.


Genetic variants of human erythrocyte glucose-6-phosphate dehydrogenase. Discrete conformational states stabilized by NADP +  and NADPH.


Evidence for the compartmentation of cholesterol in rat-liver microsomes.


The inhibition of pineal hydroxyindole-O-methyltransferase by haloperidol and fluphenazine.


Some properties of a water soluble phosphated nonylphenol ethoxylate.


The effects of particle size, shape and moisture content on the tensile properties of procaine penicillin powders.


An infrared study of the association between some 2,6-diamino-8,9-disubstituted purines and phenobarbitone in chloroform.


Correlation of chromatographically obtained substituent constants and analgesic activity.


The packing properties of moist beds of bulk solids.


The effect of binding agents on some properties of granules of lithium carbonate and on the tablet porosity.


Instrument of a hard shell encapsulation machine.


The preparation of controlled release particles in the sub-sieve size range.


Extracellular lipids of Pseudomonas aeruginosa obtained from liquid media by aqueous n-butanol.


Production of pure cordycepin (3'-deoxyadenosine) from Cordyceps militaris.


Elimination of an R-factor by trimethoprim.


Centrifugal freeze-drying of spores of Penicillium chrysogenum WIS 54-1255 from sodium glutamate.


Non-aqueous liquids as modifiers of lethal damage induced by Bacillus megaterium spores by gamma-rays.


The interaction of Escherichia coli and magnesium trisilicate in aqueous suspension.


The interaction between kaolinite and Staphylococcus aureus.


The kinetics of thermal dehydration and transformation of solid cortisone acetate.


Interaction of large organic ions of opposite charge and the calculation of extra-thermodynamic substituent constants.


The influence of polysorbate 20 on the transfer of salicylic acid across a Cellophane membrane.


The adsorption of cetyl trimethylammonium bromide from mixed surfactant solutions.


The effect of cetyltrimethylammonium bromide on the hydrolysis of p-substituted ethylbenzoates.


The stability of aqueous solutions of promethazine hydrochloride as a function of pH.


The stability of sulphafurazole when complexed with diethanolamine.


Elastic recovery and surface area changes in compacted powder systems.


An investigation of some of the factors influencing tablet strength.


Surface geometry of some microcrystalline celluloses.


An evaluation of a new pore model for plastic matrix tablets.


A preliminary study of the thermal and photochemical degradation of thiamine hydrochloride.


Water vapour permeability of poured and sprayed polymer films.


The photodegradation of L-dopa and related compounds.


Photolysis of a methaqualone metabolite.


Coenzyme B 12 : correlation of ultraviolet, electrophoretic and enzyme assay methods.


Photolytic decomposition of 3 cobalamins: a quantitative study.


The determination of diamorphine by thin-layer chromatography and direct-reflectance spectrophotometry.


The determination of low concentrations of disulfiram by cathode ray polarography.


Mechanisms of action of a hemicholinium analogue at the neuromuscular junction.


Neuromuscular blocking and local anaesthetic activities of warifteine hydrochloride, an alkaloid isolated from Cissampelos ovalifolia D.C.


Adrenoceptors in the central nervous system concerned with cardiovascular control.


The neuromuscular and other blocking actions of 4,17a-dimethyl-4,17a-diaza-D-homo-5 -androstane dimethiodide.


Effects of oestrogen and progesterone on brain monoamines: interactions with psychotropic drugs.


Permanent changes in brain monoamine metabolism induced by the administration of psychotropic drugs during the pre- and neonatal periods in rats.


The partial fate of aminoglutethimide in man.


Screening drugs for ototoxicity.

Screening drugs for ototoxicity.


The application of a model T Coulter Counter to dissolution rate studies.


Comparative dissolution rates of the anhydrous and trihydrate forms of ampicillin.


The role of natural convection in the dissolution of salicylic acid.


Some effects of micellar concentrations of polysorbate 20 on the dissolution rate of salicylic acid.


Effect of certain non-ionic surface active agents on the electrophoretic mobility of polystyrene latices.


Effect of the nature of the disperse phase on the stability of oil-in-water emulsions.


Some investigations into the effect of cycling temperature on the drop size of an oil-in-water emulsion.


Some effects of germination changes in fungal spores upon their resistance to chemical and physical agents.


The influence of EDTA and PEA upon the fungistatic action of aminoacrine hydrochloride.


Preliminary investigation of the preservative properties of 3-phenylpropanol.


Preservation of sulphacetamide eye drops.


The uptake by Escherichia coli and growth inhibitory properties of methyl, ethyl and propyl p-hydroxybenzoates.


The uptake of chloroquine by Escherichia coli.


The effect of pH on the inhibitory activity of chloroquine against Escherichia coli.


A structural least squares method for oral absorption constants.


The effect of chloroquine and its congeners on mitochondrial oxidation.


The determination of protein-binding by the Hammett rho constant for O-hydroxyl.


The binding of amphetamine and related compounds to plasma protein.


Aluminium hydroxide and pepsin.

Aluminium hydroxide and pepsin.


Intestinal absorption of macroanions.

Intestinal absorption of macroanions.


Synthesis of spiro(oxindole-3,2'-bicyclo(2.2.1)hept-5'-ene)derivatives.


Further investigation of the sterol ester fraction of Digitalis purpurea L.


N-oxides isolated during the alkaloid screening of Uncaria species.


The identification of peptide alkaloids from Euonymus europaeus L. (Celastraceae).


Iridoid content of some Scrophularia species.


The interaction of penicillins with phospholipids.


The influence of solvents on the sorption of benzocaine by nylon 6 (polycaprolactam).


Zinc and copper(II) ion catalyses of penicillins in alcohols.


A correlation between solubility and carminative activity.


Distribution coefficients and anabolic activities of some nandrolone esters.


Continuous shear, viscoelastic and spreading properties of a new topical vehicle, FAPG base.


Placebo response to white soft paraffin-propylene glycol in skin blanching test.


Viscoelastic properties of pharmaceutical semi-solids: characterization of the Plastibases for bioavailability studies.


Oscillatory testing of o-w emulsions containing mixed emulsifiers of the surfactant-long chain alcohol type: self-bodying action.


Formulation of a sterile surgical lubricant.


Some physical characteristics of magnesium stearate.


A study of the formulation of steroidal suspensions.


The effect of particle size on the granulation of lactose by massing and screening.


Penicillin resistance in Staphylococcus aureus 893 not mediated by  -lactamase.


Determination of thermodynamics of the methylene group in solutions of drug molecules.


Thermoelastic properties of preformed compacts.


The effect of temperature on the mechanical properties of some pharmaceutical powders in relation to tableting.


Comparison of oral and percutaneous routes in man for the systemic administration of 'ephedrines'.


Stabilization of oil-in-water emulsions by alkyl sulphates: the influence of the nature of the oil on stability.


Changes in antibacterial activity of thiomersal and PMN on autoclaving with certain adjuvants.


Effect of polysorbate 80 and phenylethanol on the antibacterial activity of fentichlor.


Eosinophilia following radiation therapy.


Factors affecting the coagulase release by Staphylococcus aureus.


Effect of growth-regulating substances on the biomass and lipids of some fungi.


A study on cytomegalovirus by the gel precipitation method.


The role of effluents in the spread of Salmonellae.


Exocytosis in Entamoeba.

Exocytosis in Entamoeba.


Sleeping sickness survey in the Serengeti area (Tanzania) 1971. I. Examination of large mammals for trypanosomes.


Morphological changes in human schistosomiasis and certain analogies in ancient Egyptian sculpture.


Sleeping sickness survey in the Serengeti area (Tanzania) 1971. 3. Discussion of the relevance of the trypanosoma survey to the biology of large mammals in the Serengeti.


Sleeping sickness survey in the Serengeti area (Tanzania) 1971. II. The vector role of Glossina swynnertoni Austen.


Isolation of Trypanosoma (Trypanozoon) rhodesiense from game and domestic animals in Musoma District, Tanzania.


Histological examination of wild animals naturally infected with pathogenic African trypanosomes.


On the ultrastructure of Trypanosoma (Trypanozoon) brucei in the course of its life cycle and some related aspects.


Glutamine synthetase of the nitrogen-fixing alga Anabaena cylindrica.


The effects of aflatoxin B 1  in vivo on membrane--ribosome association. The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.


Physiological and behavioural processes in early maternal deprivation.


Conservation-withdrawal: a primary regulatory process for organismic homeostasis.


Changes in catecholamine-controlling enzymes in response to psychosocial activation of the defence and alarm reactions.


Characterization of a serum inhibitor of MLC reactions.


Improving information exchange between scientists and representatives of the communications media: conference II.


Chronic granulomatous disease--pieces of a cellular and molecular puzzle.


Annual administrative reviews: nursing.

Annual administrative reviews: nursing.


Annual administrative reviews: hospital-physician relations.


Health manpower and the education of health personnel: comment.


Review of the Intra-Science Research Foundation Symposium on the chemistry and pharmacology of prostaglandins.


The psychotherapy of schizophrenia: an NIMH program.


Antihistaminic activity of 4-(2, 1, pyrrolidino-ethoxy) quinoline.


Tumor induction by immunologically activated murine leukemia virus. A graft-vs.-host reaction (GVHR) was induced in young male CAF(I) and CB6F(1) mice by the administration of BALB/cJ spleen cells. A proportion of such mice subsequently developed lymphoreticular rumors. Cell-free extracts (CFEs) prepared from the reticular tissues of CAF(1) mice killed at intervals after the induction of the GVHR were tested for their capacity to produce the same tumors in a litter of syngeneic mice inoculated at birth. 12 of 29 (41.4%) such extracts were positive, causing lymphoreticular tumors in one or more littermate recipients. The positive CFEs came from donors killed at all stages of the GVHR, from tumor-bearing mice as well as from non-tumor-bearing mice. However, whereas less than 30% of CFEs from mice killed within 12 mo of GVHR induction were oncogenic, the incidence of oncogenic extracts from mice killed 12-15 mo after GVHR induction rose to 75%. None of the CFEs prepared from nine normal uninjected male CAF(1) mice killed between the ages of 8 and 18 mo transmitted tumors to recipients. CFEs prepared from CAF(1) mice with the GVHR were tested for infectious murine leukemia virus (MuLV) using the XC assay and also for complement-fixing (CF) group-specific MuLV antigen. Substantial titers of B-tropic MuLV and CF antigen were detected in at least half the extracts from mice killed 11-14 mo after GVHR induction. During the first few months of GVHR induction, MuLV titers were low and CF antigen was absent. Neither infectious MuLV nor CF antigen were detected in CFEs prepared from normal control mice. Serially passed CFEs originating from a CB6F(1) GVHR-induced RCN caused similar tumors in successive generations of syngeneic recipient mice. These lymphoreticular tumors were shown to contain infectious MuLV, CF MuLV antigen, and C-type particles. These data together provide evidence that MuLV is activated during the GVHR and that it is responsible for the eventual development of lymphoreticular tumors.


Graft-versus-host reactions across different regions of the H-2 complex of the mouse. H-2 crossovers and their parental strains were arranged into 35 combinations in which the adult donor of spleen cells differed from the newborn recipient in the whole H-2 complex, or in three, two, or one region of the complex. A Simonsen splenomegaly assay was then used to test the contribution of the individual H-2 regions to the graft-versus-host reaction (GVHR). It was shown that the strongest GVHR was associated with the Ir region. Differences in the Ir region caused significant splenomegaly in spite of the fact that no antigens detectable by conventional serological methods have thus far been associated with this region. Differences in the K and D regions showed only a borderline effect on GVHR in spite of the fact that these regions code for most, if not all, of the antigens detectable by conventional serological and transplantation methods. The K region alone caused no stronger GVHR than the D legion alone; however, K + Ir region differences led to much stronger GVHR than D region differences. The Ss-Slp region also showed only a borderline effect on GVHR. Differences in two or more H-2 regions usually caused greater splenomegaly than differences in each of the regions separately. On the basis of these findings it is concluded that the strongest GVHR is caused by genes distinct from the known histocompatibility genes of the H-2 complex. It is speculated that the GVHR genes are identical with the mixed lymphocyte reaction (MLR) and Ir genes and that the product of these genes are receptors on the surface of the thymus-derived lymphocytes (T cells).


Mechanism of graft-versus-host-induced lymphadenopathy in mice. Trapping vs. proliferation. Graft-vs.-host (GVH)-induced lymphadenopathy of the popliteal lymph node has been produced in C57BL/6 x A/J F(1) (BAF(1)) mice by injecting A/J spleen cells into the rear footpads. By giving (51)Cr-labeled BAF(1) lymphoid cells intravenously to the hosts, 24 h before sacrifice, we have demonstrated that a large portion of the GVH-induced lymphadenopathy is due to the trapping of circuating lymphocytes in the challenged lymph nodes. Most of the remaining enlargement can be attributed to proliferation of host cells within the reacting lymph nodes. Conditions have been defined under which the weights and [(14)C]thymidine incorporation of the popliteal nodes can be plotted against the dose of injected A/J spleen cells on a double-log scale to give a linear dose-response. The popliteal lymph node GVH assay is a simple and effective means of quantitating immune reactivity to histocompatibility antigens in mice.


Fear-provoking recommendations, intentions to take preventive actions, and actual preventive actions.


The surgeon's assistant in private surgical practice and in the university hospital.


Amoxycillin (Amoxil) in the treatment of respiratory disease in children.


The importance of dosage in antipsychotic drug administration--a review of dose-response studies.


The preparation of soluble high molecular weight NAD derivative active as a cofactor.


On the solubilization of NADPH-cytochrome c reductase from rat liver microsomes with crude pancreatic lipase.


Treatment patterns in psychiatry: relationships to symptom features and aging.


Au-SH antigen, hepatitis, and polyarteritis nodosa.


Psychophysiological discriminants of reactive depression.


Histamine: effect on self-stimulation.

Histamine: effect on self-stimulation. When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.


Malignancy as a complication of immunosuppressive therapy.


The Navy dermatology technician. A survey of his attitudes and aspirations.


Acute respiratory distress syndrome in adults. Definition, etiology and treatment.


Neurospora 6-phosphogluconate dehydrogenase. II. Properties of two purified mutant enzymes.


Stimulation of  32 P i  incorporation into phosphatidylinositol and phosphatidyglycerol by catecholamines and  -adrenergic receptor blocking agents in rat pineal organ cultures.


Differences between germ-free and conventional rats in liver microsomal metabolism of steroids.


Autonomic dysreflexia in injuries below the sixth thoracic segment.


Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of the non-specific membrane affinity of nine  -adrenergic blocking agents.


Dental health of four-year-old children.


Restricted riboflavin: within-subject behavioral effects in humans.


Correlation of alcohol and tolbutamide blood clearance rates with microsomal alcohol-metabolizing enzyme activity.


Effect of adenine nucleotides on the oxidation of methyl groups in liver mitochondria.


Valve replacement: present status of homograft valves.


Oxidative phosphorylation in Escherichia coli K-12: the genetic and biochemical characterisations of a strain carrying a mutation in the uncB gene.


In vitro antibody-enzyme conjugates with specific bactericidal activity. IgG with antibacterial antibody opsonic activity was isolated from rabbit antisera produced by intravenous hyperimmunization with several test strains of pneumococci, Group A beta-hemolytic streptococci, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli. Antibody-enzyme conjugates were prepared, using diethylmalonimidate to couple glucose oxidase to IgG antibacterial antibody preparations. Opsonic human IgG obtained from serum of patients with subacute bacterial endocarditis was also conjugated to glucose oxidase. Antibody-enzyme conjugates retained combining specificity for test bacteria as demonstrated by indirect immunofluorescence. In vitro test for bactericidal activity of antibody-enzyme conjugates utilized potassium iodide, lactoperoxidase, and glucose as cofactors. Under these conditions glucose oxidase conjugated to antibody generates hydrogen peroxide, and lactoperoxidase enzyme catalyzes the reduction of hydrogen peroxide with simultaneous oxidation of I(-) and halogenation and killing of test bacteria. Potent in vitro bactericidal activity of this system was repeatedly demonstrated for antibody-enzyme conjugates against pneumococci, streptococci, S. aureus, P. mirabilis, and E. coli. However, no bactericidal effect was demonstrable with antibody-enzyme conjugates and two test strains of P. aeruginosa. Bactericidal activity of antibody-enzyme conjugates appeared to parallel original opsonic potency of unconjugated IgG preparations. Antibody-enzyme conjugates at concentrations as low as 0.01 mg/ml were capable of intense bactericidal activity producing substantial drops in surviving bacterial counts within 30-60 min after initiation of assay. These in vitro bactericidal systems indicate that the concept of antibacterial antibody-enzyme conjugates may possibly be adaptable as a mechanism for treatment of patients with leukocyte dysfunction or fulminant bacteremia.


Pneumonia and pulmonary infarction in sickle cell anemia.


Specific leukocyte receptors for small endogenous hormones. Detection by cell binding to insolubilized hormone preparations. Receptors for small endogenous hormones on human leukocytes were studied by insolubilizing the hormones and incubating them with the cells. Histamine, norepinephrine, and prostaglandin E(2) (PGE(2)) were conjugated to either of two types of carrier: (bovine or rabbit) serum albumin or a random copolymer of DL-alanine and L-tyrosine. The conjugates were linked to agarose beads (Sepharose) and the resultant drug-conjugate-beads were incubated with leukocytes. Norepinephrine (when linked to its carrier via glutaraldehyde) and histamine preparations bound the majority of leukocytes. The binding appeared to be specific for the hormones tested. For example, the binding by histamine-rabbit serum albumin-Sepharose was prevented or reversed by high concentrations of histamine and histamine antagonists, but not by catecholamines or their pharmacologic antagonists. Similarly, binding of cells to the norepinephrine conjugate was inhibited by some catecholamines and propranolol, but not by histamine or histamine antagonists. Conjugates of norepinephrine linked via carbodiimide did not bind cells. The protein or copolymer carriers did not contribute to binding per se. The hormone-protein-conjugates bound more cells than the hormone-polymer conjugates. The former (unlike the free amines) failed to stimulate accumulation of cyclic AMP in leukocytes. The norepinephrine linked to polymer via glutaraldehyde, however, did stimulate leukocyte cyclic AMP accumulation, possibly because of the flexibility of the polymer. Columns of the various Sepharoses were used to determine the distribution of receptors to each hormone in mixed leukocyte populations. The majority of cells appeared to have receptors for both histamine and norepinephrine (bound through glutaraldehyde). Receptors to prostaglandins may have been detected by the column procedure, but their distribution could not be quantitated. The approach described provides a means to separate leukocytes on the basis of what are likely to be preformed receptors to small endogenous hormones, and to study the physiologic importance and function of the receptors.


The top drugs. Inderal--blocking beta receptors.


T-lymphocyte function following burns: dependence of response on antigenic disparity and size of injury.


Evidence for two separate adenyl cyclase systems responding independently to parathyroid hormone and  -adrenergic agents in the renal cortex of the rat.


"Xenogeneic resistance" to rat bone marrow transplantation. I. The basic phenomenon.


Cellular heterogeneity in the thymus: graft-versus-host activity of fractionated thymus cells in the chicken.


Photoreduction of ferredoxin-NADP in the presence and absence of ferredoxin-reducing substance (FRS).


Comparative effects of cytotoxic agents on transplanted hematopoietic and antibody-producing cells.


Effect of aminoacetonitrile on the fine structure and cytochemistry of hepatic cells in rats fed two carcinogenic N-nitrosodialkylamines.


Chronic administration of chlorcyclizine and meclizine to rats: accumulation of a metabolite formed by piperazine ring cleavage.


Drug stimulation of  -aminolevulinic acid synthetase and cytochrome P-450 in vivo in chick embryo liver.


Nitroreductase activity of mammalian liver aldehyde oxidase.


Relative beta adrenergic receptor blocking activity in dogs after intravenous and intraportal vein administration: bunolol, propranolol, their levo isomers and sotalol.


Studies on the cytochrome P-450-containing mono-oxygenase system in human kidney cortex microsomes.


Renal lesions with organized deposits and lipid as part of the host versus graft syndrome in parent-F 1  mouse chimeras.


Effects of stimulants on observed behaviour of rats on six operant schedules.


Effects of neurohumoral and adrenergic agents on cyclic AMP levels in various areas of the rat brain in vitro.


Inhibition of adrenergic neurotransmission by clonidine: an action on prejunctional  -receptors.