Physical properties of single- and double-stranded coliphage ribonucleic acid. 1. The physical characteristics of single- and double-stranded coliphage RNA with regard to their sedimentation behaviour in gradients of sucrose in high or low ionic conditions were examined. The effect of heat on their sedimentation characteristics was also determined. 2. Single-stranded coliphage RNA was found to exist in three different forms having sedimentation coefficients 28s, 20s and 12s. The latter two were interchangeable, depending on ionic strength. All three were almost equally infectious to spheroplasts. 3. Double-stranded coliphage RNA was found to be non-infectious to spheroplasts and had sedimentation coefficients 15s and 12s. Thermal denaturation gave rise to infectious single-stranded 12s RNA. 4. Four possible hypotheses on the mechanism of replication of coliphage RNA are discussed.


Binding of normal serum globulins to tanned red blood cells.


Neutralization of an infectious herpes simplex virus-antibody complex by anti-gamma-globulin.


Localization of noncovalent interactions between the heavy chains of rabbit gamma-G-globulin.


A model for colostral IgA.

A model for colostral IgA.


Bilateral hydronephrosis resulting from a transitional epithelial carcinoma in a dog.


A new staining method (OTO) for enhancing contrast of lipid--containing membranes and droplets in osmium tetroxide--fixed tissue with osmiophilic thiocarbohydrazide(TCH).


Organization of the spino-cervico-thalamic system.


Neuroglial relationships in the thoracic ganglion of the fiddler crab, Uca.


The microscopic anatomy and ultrastructure of the nervous system in the earthworm (Lumbricus sp.) with emphasis on the relationship between glial cells and neurons.


Myeloarchitectonics of the occipital cortex in dog and general remarks on the myeloarchitectonics of the dog.


Effect of antibiotic administration on mastitis screening tests and milk composition.


Some bridgehead-substituted tetrahydroacenaphthenones.


Heterogeneity of glycopeptides from a homogeneous immunoglobulin.


Comparison of the in vitro I 131 triiodothyronine resin uptake test and the protein bound iodine in the parturient and in the newborn infant (cord blood).


An improved method of fixation for formalin-sensitive enzymes with special reference to myosin adenosine triphosphatase.


Staining of insulin with aldehyde fuchsin.


Subjective assessment of pain and its relationship to the administration of analgesics in patients with advanced cancer.


Immunoglobulin class and light chain type of human antibodies. Studies with anti-gammaG, -gammaM, -gammaA-globulin, -beta 1CA, E-globulins and anti-kappa, -lambda chains reagents.


Platelets and blood coagulation in arterial and venous blood.


Protein separation at the cellular level by micro disc electrophoresis.


Localization of herpes simplex antigen and virus. In the corneal stroma of experimental herpetic keratitis.


Further appraisal of in vivo staining properties of oral cancer.


Electrophoretic determination of vanilmandelic acid (VMA) in urine by direct application to cellulose acetate.


Excitability of EEG "synchronizing" and "desynchronizing" neurones in the thalamus and the brain-stem of the cat. I. The applicability of strength-duration determinations and conditioning-test technique.


Limbic system seizures in the kitten.

Limbic system seizures in the kitten.


Excitability of EEG "synchronizing" and "desynchronizing" neurones in the thalamus and the brain-stem of the cat. II. Chronaxies and refractoriness.


Excitability of EEG "synchronizing" and "desynchronizing" neurones in the thalamus and the brain-stem of the cat. 3. Patterns of interaction between pulse pairs applied to the diffuse thalamic projection system.


Habituation to electrical stimulation of the brain in unanesthetized cats.


Auditory evoked response and reaction time.


Endogenous spike discharges as conditioned stimuli in man.


A fast and spikey spindle variant in children with organic brain disease.


Responses of hypothalamic neurons to electrical stimulation in the amygdala and the hypothalamus.


Preparation and implantation of minute pellets in the brain of the neonatal rat.


Differential cerebral transmission of acoustic and visual information.


Temporal characteristics of sensory interaction: evoked potential and reaction time observations.


Development of the contingent negative variation in children.


Human cerebral evoked responses to odorous stimuli.


DC recordings of summated visual evoked cortical responses in man.


Spatial and temporal aspects of rhythmic after-waves (after-discharge) to flashing in man.


Effect of facial expression on the averaged evoked response to light in man.


Visually evoked potentials during perceptual masking in man and monkey.


The effect of cryogenic blocking of the diffuse thalamocortical recruiting system upon visually evoked potentials and behavior.


"Global" cerebral evoked potentials of the rat elicited by light flashes and behavior.


Spectral analysis of the EEG during waking and sleeping.


Relationship of fetal activity to maternal EEG sleep stage.


Behavior and quantitative EEG correlations during treatment of behavior-disturbed adolescents.


The sleep cycle of dyskinetic patients before and after cryothalamotomy.


Power spectral analysis of the EEG in newborn infants during sleep.


The development of the EEG sleep patterns in normal infants and children: a longitudinal developmental study.


Cerebral concussion in children--a longitudinal EEG profile.


EEG studies of diabetic progeny.

EEG studies of diabetic progeny.


Maturation and topography of the auditory evoked response of the prematurely born infant.


Maturation of the evoked response to auditory stimuli in human infants.


EEG-clinical correlates in mongoloids confirmed by karyotype.


Development of electrical activity in the cerebral cortex of the newborn rat.


Electrophysiology of "epileptic neurons".


Unit membrane shifts and firing patterns during spreading depression.


Analysis of single cell activity in the mirror focus of the frog.


Micro-electrode studies of the afferent and efferent connections of neurons in the sensori-motor cortex of the cat.


Periods of suppression of muscular activity related to the spike of spike and wave discharges.


The clinical correlates of the mid-temporal or Sylvian spikes.


Volume conduction and the 14 and 6/sec positive spike phenomenom.


EEG studies in complex migraine.

EEG studies in complex migraine.


EEG activation after sleep deprivation.

EEG activation after sleep deprivation.


The occurrence of centrencephalic and focal seizure patterns in the same patient.


Amplitude histograms of the EEG as an indicator of the cooperative behavior of neuron populations.


Computer pattern recognition of the human electroencephalogram.


A normative library of the human EEG, assessed by computer analysis in relation to behavioral states.


The cooperative behavior of neuronal populations during sleep and mental tasks.


Cross sectional plotting of EEG potential fields.


The parietal alpha center.

The parietal alpha center.


The effect of experience on the firing pattern of visual cortical neurons.


Comparison of intracellular potentials and ECoG activity in isolated cerebral cortex.


Effects of orbito-frontal ablation on thalamo-cortical potentials and behavior in the cat.


Slow potential changes from cat cortex and classical aversive conditioning.


Rapid decompression in a chimpanzee with implanted electrodes: a case report.


Studies on the epilepsy induced by photic stimulation in Papio papio.


Electroencephalographic and unit discharge patterns of the striate cortex of visually deprived kittens to photic stimuli.


Immunologic responses in relation to experimental epilepsy.


Bilateral symmetrical epileptogenic foci in cerebral cortex of the monkey.


Phase reversal of EEG during attentive, associative and reactive conditions.


Triphasic spikes in the EEG due to profound electrolyte imbalance.


EEG abnormalities in functional mental disorders.


Auditory evoked potentials during alterations in "attention".


Statistical tests of average evoked response computations.


Repetitive response to electrical polarization in a cerebral fiber tract.


Asymmetric response to photic stimulation.


Protracted vertex and frontal waves during drowsy states.


EEG phase differences and attenuation patterns during rest and while drawing.


An analysis of variance of spectral characteristics over nine discrete epochs of resting electroencephalographic activity in a group of forty-two subjects.


Habituation of the alpha blocking response.


Comparative anticonvulsant effect of several Librium analogs.


Intravenous diazepam in seizure disorders.


Influence of increased intracranial pressure on evoked responses to sensory stimulation.


Auditory evoked responses during sleep in premature and full-term newborn infants.


Hypothyroidism and development of bioelectric brain phenomena.


Serial EEG observations on the premature infant.


Studies on the mode of action of the fifth, sixth and seventh component of human complement in immune haemolysis.


Morphological changes induced in human red cells by rabbit univalent antibody.


Adsorption of heterologous gamma-globulins by chopped guinea-pig lung.


The biological effects of anti-thyroid antibodies. Thyroid eosinophilia following passive transfer of anti-thyroglobulin antibody.


Synthesis and secretion of gamma-globulin by lymph node cells. II. The intracellular segregation of amino acid-labeled and carbohydrate-labeled gamma-globulin.


A study of the cellular pathogenesis of vesicular exanthema of swine virus in pig kidney cells.


A coronary-care unit in the routine management of acute myocardial infarction.


Effect of walking on blood-pressure in systemic hypertension.


Catecholamine levels in portal, hepatic, and systemic venous blood in portal hypertension.


Thin-layer Sephadex chromatography and immunodiffusion.


Arterial hypertension cured by improved coronary blood supply. (Beck-Vineberg).


Fibrinolytic activity of human veins.

Fibrinolytic activity of human veins.


Furcation involvements correlated with enamel projections from the cementoenamel junction.


Additional evidence of the relation between subacute inclusion-body encephalitis and measles virus.


Normal sex-chromosome complement in a case of familial osteoarthropathy.


Demyelinating peripheral neuropathy and liver disease.


Acute epiglottitis in adults due to infection with Haemophilus influenzae type b.


Hodgkin's disease in woodworkers.

Hodgkin's disease in woodworkers.


Remission of psoriasis with low dietary tryptophan.


A possible immunological influence on sex ratio.


Profile of poverty.

Profile of poverty.


Infarction of the spinal cord.

Infarction of the spinal cord.


Percutaneous transhepatic cholangiography.


Social and economic effects of regular dialysis.


Education for war and peace.

Education for war and peace.


The National Health Service in 1966.

The National Health Service in 1966.


Limitation of right of appeal.

Limitation of right of appeal.


Alexander Stuart Murray Macgregor.

Alexander Stuart Murray Macgregor.


Somerville Hastings.

Somerville Hastings.


Systemic lupus erythematosus with cryoglobulinaemia, peripheral gangrene, and transplacental passage of the LE factor. A case report.


Pesticidal control of contaminant macro-invertebrates encountered in laboratory culture of marine sea weeds. USNRDL-TR-15.


Fetal liver cells: a source of specific immunoglobulin production in radiation chimeras. USNRDL-TR-67-26.


Normal human serum parameters for simulated altitude and aerospace flights. II. Estimation of change in albumin, gamma globulin albumin-gamma globulin ratio, and A-G ratio.


Thyroid abnormalities after radiation exposure in infancy.


Migratory osteolysis of the lower extremities.


Effect of heparin on the one-stage prothrombin time. Source of artifactual "resistance" to prothrombinopenic therapy.


Late effects of radioactive iodine in fallout. Combined clinical staff conference at the National Institutes of Health.


Tests of thyroid function.

Tests of thyroid function.


Immune studies in multiple sclerosis.

Immune studies in multiple sclerosis.


Lactate dehydrogenase isoenzymes of small-intestinal mucosa in malabsorption of intestinal and pancreatic origin.


Fine structure of quiescent and germinating aeciospores of Cronartium fusiforme. Aeciospores of the long-cycle heteroecious rust fungus, Cronartium fusiforme, were found to have an extremely thick cell wall with striking spicules protruding from it. The wall was readily degraded by commercial chitinase, but spicules were unaffected. Quiescent spores contained two nuclei with distinct nuclear membranes possessing many pores. Numerous membrane-bounded lipid bodies were found both in wild-type orange and in white mutant aeciospores. An abundance of irregularly ovoid mitochondria was present in quiescent spores. After glutaraldehydeosmium fixation, the surface of the mitochondria appeared to be covered with ribosomes or microtubules in a paracrystalline array, whereas after permanganate fixation only smooth outer mitochondrial membranes were noted. The latter fixative revealed abundant vesicular endoplasmic reticulum in the spore. Spores incubated at 20 C on agar produced one to five distinct germ tubes within 65 to 180 min. These thin-walled tubes exhibited varying degrees of branching, and reached a total hyphal length of 300 to 500 mu prior to rupturing. Emergence of germ tubes took place through a pore in the spore wall and appeared to be mainly a physical flowing of cytoplasm from the spore into the germ tube without division of nuclei or other cell organelles. On completion of germination, the protoplasm of the germ tube contained both nuclei and nearly all of the other spore contents. Mitochondria had smooth outer membranes, were greatly elongated, and possessed distinct longitudinal cristae. A limited amount of rough endoplasmic reticulum was arranged parallel to the germ tube wall. Other organelles seen in germ tubes were lipid bodies, concentric membrane figures, and numerous ribosomes. Lipid bodies appeared smaller and fewer in number than in quiescent spores.


Acid mucopolysaccharides in the development of the Pacific great skate, Raja binoculata.


The use of thiazolyl blue for the detection of dehydrogenases on starch gels.


Heterogeneity of H and L chains of normal and myeloma gamma-G-globulin.


Degradation of human gamma-G-globulin with cyanogen bromide.


Isolation of aurantiacin from Hydnellum caeruleum.


Complement: substitution of the terminal component in immune hemolysis by 1,10-phenanthroline. The participation of metal ions in the terminal step of immune cytolysis was investigated with chelating agents. 1,10-Phenanthroline induced lysis of sensitized sheep erythrocytes which had reacted with the first eight components of human complement. Hemolysis caused by 1,10-phenanthroline resembled lysis produced by the ninth component of complement in dependence on cell-bound eighth component and on temperature and in inhibition by 0.09M ethylenediaminetetraacetic acid. Bivalent metal ions reduced the hemolytic capacity of 1,10-phenanthroline, and Fe(++) inhibited the activity of the ninth component. Since trivalent iron had no such effects, it is postulated that the hemolytic activity of 1,10-phenanthroline and the ninth component of complement is a function of their affinity for Fe(++).


Microscopic, cultural and serologic studies on Mycobacterium leprae and other mycobacteria isolated from leprosy patients.


Deficient complement fixation by aggregated gamma globulin from hypogammaglobulinemic patients. We found that several normal samples of aggregated gamma globulin consistently fixed essentially equal amounts of guinea pig complement, while samples of gamma globulin from three of four hypogammaglobulinemic patients were markedly deficient in this biologic function. Thus, the previously observed limited heterogeneity of gamma globulin in patients with hypogammaglobulinemia is also associated with inefficiency in at least one biological function.


Long term oral anticoagulation following myocardial infarction. A Veterans Administration cooperative study.


Prophylactic anticoagulant therapy in prostatic surgery.


The distal spermatic tract after suprapubic transvesical prostatectomy as shown by vaso-seminal vesiculography.


Immunoglobulin levels in rheumatoid arthritis: comparison with rheumatoid factor titers, clinical stage and disease duration.


The distribution of serum immunoglobulins, anti-gamma-G globulins ("rheumatoid factors") and antinuclear antibodies in White and Negro subjects in Evans County, Georgia.


The lack of effect of methimazole therapy in lepromatous leprosy. Reassessment by examination of bacterial morphology.


Localization of the immunoglobulin factors Gm(a), Gm(b) and Gm(x) in lymphoid tissue obtained from an individual of Gm ax/ab genotype.


Immune responses of mice to iodoacetate-treated Ehrlich ascites tumour cells.


Apparatus for automatic preparation and scanning in cervical cytology.


Symbolic meaning and color naming.

Symbolic meaning and color naming.


Simultaneous demonstration of normal boutons and degenerating nerve fibres and their terminals in the spinal cord.


Recoveries of iodine-131-labelled iodo-amino-acids in the plasma protein-bound iodine assay.


An acquired inhibitor to coagulation factor 13.


Clinical usefulness of measurements of thyroxine in serum.


Epithelial structure in the anterior segment of the vas deferens of an isopod, Porcellio scaber (Latreille).


Refsum's syndrome. Heredopathia atactica polyneuritiformis.


Thyroxine turnover and transport in active acromegaly.


Iodine intake, excretion and thyroidal accumulation in healthy subjects.


Abnormal binding of thyroid hormone in sera from patients with Hashimoto's disease.


Diagnostic value of thyroid antibodies.

Diagnostic value of thyroid antibodies.


Cytoplasmic inclusions in estrogen-induced testicular interstitial-cell tumors in mice.


Spontaneous cure of prostatic fibroadenoma by an abscess.


Temperature regulation in survivors of accidental hypothermia of the elderly.


Hepatic coma due to acute hepatic necrosis treated by exchange blood-transfusion.


Association between lepromatous leprosy and Australia antigen.


Rapid reversion of electrocardiographic abnormalities after treatment in two cases of scurvy.


A comparison of the haemagglutination-inhibition test and the neutralisation test for the detection of rubella antibody.


Diagnosis of rupture of abdominal aortic aneurysms.


Autoimmune antibodies in mongol families.


Genetic aetiology of lactose intolerance.


Traumatic haemogloinuria caused by karate exercises.


Intrinsic-factor secretion in response to pentagastrin.


Serum-lipids and cerebrovascular disease.


Oedema in pregnancy.

Oedema in pregnancy.


Acute keratitis in psoriatic patients using triacetoxyanthracene.


Medical treatment of peptic ulcer.

Medical treatment of peptic ulcer.


Doctor, patient and public.

Doctor, patient and public.


Public squalor.

Public squalor.


Polymyalgia rheumatica.

Polymyalgia rheumatica.


Spread of viral hepatitis.

Spread of viral hepatitis.


Crackles and wheezes.

Crackles and wheezes.


Ernst Neumark.

Ernst Neumark.


Release of 5-hydroxytryptamine from mouse peritoneal mast cells during active and passive anaphylactic reactions.


Hyponatremia after section of pituitary stalk for diabetic retinopathy.


Alterations in protein fractions of heated blood serum.


Analysis in protein iodination systems.

Analysis in protein iodination systems.


Umbilical cord symbolism of the spider's dropline.


The Abu Symbol.

The Abu Symbol.


Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability. I have analyzed the available amino acid sequence data from 30 myelomatosis-derived proteins. Several types of variation are apparent. I conclude that a major and genetically predetermined contribution to the variability of these proteins and of antibodies could be provided by chromosomal rearrangements resulting from somatic recombination between similar but not identical genes in antibody gene pairs. My hypothesis suggests many new types of experiment and can be tested (31).


An unusual case of chronic retention of urine. A case presentation.


Perceptual judgment of schizophrenics and normals as a function of social cues and symbolic stimuli.


KTSA sorting norms for school age children.


Scorer reliability of the KTSA.

Scorer reliability of the KTSA.


Magnocellular neurosecretory centers in the rat hypothalamus.


Degeneration time for optimal staining by Nauta technique. A study on transected vagal fibers of the cat.


The red nucleus and its efferent nervous pathways in the monkey.


A quantitative study on the postnatal development of the cerebellar vermis of mouse.


The role of the kidney in the catabolism of Bence Jones proteins and immunoglobulin fragments. The role of the kidney in the catabolism of Bence Jones proteins, intact IgG molecules, and isolated L chains, Fab and Fc fragments of IgG, was studied. The proteins were purified, radioiodinated, and their survival times measured in nephrectomized, ureter-severed, and control mice. Active endogenous catabolism was the major factor in overall Bence Jones metabolism since excretion as proteinuria accounted for less than 25% of the total metabolism. The survival times of lambda- and kappa-type human Bence Jones proteins and the Bence Jones protein produced by mice with MPC-2 plasma cell tumor were exceedingly short in both unoperated and ureter-severed mice, with 50% of the injected protein catabolized in from 0.8-1.6 hr. In contrast, the survival of Bence Jones protein was markedly prolonged in nephrectomized animals, with 50% of the injected dose catabolized in from 9 to 17 hr. This ten-fold decrease in catabolic rate indicates that the kidneys are the major site of breakdown of Bence Jones proteins. Similar studies with other proteins indicated that the kidneys are also the major site for catabolism of isolated L chains but not of intact IgG molecules. The Fc immunoglobulin fragment was not catabolized and the Fab fragment only partially catabolized by the kidney. When ureter-severed animals were allowed to develop advanced uremia before being studied, the survival of Bence Jones protein was greatly prolonged, indicating that the catabolic process is impaired in the presence of uremia. The nature of this renal catabolism remains unknown. These observations suggest that the Bence Jones proteins and L chains observed in the urine of patients may reflect only a small fraction of such molecules synthesized by these patients. Furthermore, they provide an explanation for the prolongation of Bence Jones protein survival and the development of Bence Jones proteinemia observed in subjects with multiple myeloma and impaired renal function.


Studies on pneumonia virus of mice (PVM) in cell culture. I. Replication in baby hamster kidney cells and properties of the virus. Pneumonia virus of mice (PVM) has been serially propagated in a line of baby hamster kidney (BHK21) cells. A maximum titer of 6.3 x 10(6) TCID(50) per ml was obtained, and there was little variation in yield on serial passage. PVM grown in BHK21 cells was antigenically similar to virus obtained from the mouse lung, but was somewhat less virulent for the mouse after 10 serial passages in these cells. Virus produced by BHK21 cells agglutinated mouse erythrocytes without prior heating or other treatment. Sedimentation of PVM in the ultracentrifuge or precipitation by ammonium sulfate resulted in a loss in infectivity but an increase in hemagglutinating activity, presumably due to disruption of the virus particle. In a potassium tartrate density gradient, the major portion of infective virus sedimented at a density of approximately 1.15, and noninfective hemagglutinin, at a density of approximately 1.13. Stock virus preparations appear to contain a large amount of noninfective hemagglutinin. The replication of PVM was not inhibited by 5-fluoro-2'-deoxyuridine, 5-bromo-2'-deoxyuridine, or 5-iodo-2'-deoxyuridine. Infected cells contained eosinophilic cytoplasmic inclusions which showed the acridine orange staining characteristic of single-stranded RNA. Foci of viral antigen were observed in the cytoplasm of infected cells by fluorescent antibody staining. The results suggest that PVM is an RNA virus that replicates in the cytoplasm.


Studies on pneumonia virus of mice (PVM) in cell culture. II. Structure and morphogenesis of the virus particle. Pneumonia virus of mice (PVM) particles are spheres 80-120 mmicro in diameter, or filaments of similar diameter with lengths up to 3 micro. The particles possess an outer spike-covered envelope and helical internal component 120-150 A in diameter. Virus particles acquire their envelope by a budding process at the cell membrane; mature particles are seen only extracellularly. Dense inclusions are prominent in the cytoplasm of PVM-infected BHK21 cells by 48 hr after inoculation. The inclusions appear to consist of aggregates of the internal component of PVM, and the helical component has been isolated in a cesium chloride gradient from extracts of osmotically shocked cells. Murine erythrocytes, which are agglutinated by PVM, adsorb to the surface of infected cells and to budding and extracellular PVM particles. On the basis of its structure and morphogenesis, PVM appears to be a myxovirus; however, it does not fit into either of the established subgroups of myxoviruses. The 120-150 A diameter of the PVM internal component differs from the diameters of the internal components of the two established subgroups of myxoviruses, and suggests that a third subgroup of these viruses may exist.


Mitochondrial antibodies in primary biliary cirrhosis. I. Localization of the antigen to mitochondrial membranes. The antigen reacting with complement-fixing antibodies in the sera of patients with primary biliary cirrhosis was localized predominantly in the mitochondrial fraction of tissue homogenates obtained by differential centrifugation. Purified mitochondrial preparations had a high content of the antigen whereas purified lysosomes failed to fix complement with PBC sera. Analysis of a number of fractionation experiments showed a high correlation between antigen content and the mitochondrial enzyme succinic dehydrogenase in all fractions. There was much poorer correlation with lysosomal and micrososomal enzyme markers. The patterns of staining obtained with a fluorescein conjugate of IgG from a PBC patient closely paralleled those obtained with a histochemical method for the demonstration of succinic dehydrogenase, further confirming the mitochondrial localization of the antigen. Staining was brightest in cells containing mitochondria with well-developed cristae. Studies on mitochondria fragmented by osmotic lysis, hexane, lysolecithin, and ultrasound suggest that the antigen is associated with the mitochondrial inner membranes.


Primary stimulation and measurement of antibody production to sheep red blood cells in vitro. A method for the primary stimulation and measurement of antibody production to sheep red blood cells in vitro has been described. In this system when mouse spleen cells are incubated with sheep erythrocytes large complement-dependent plaques are formed. The number and size of plaques increases from day 1 to day 3 of incubation with an average of 4.4 plaque areas per 1 x 10(6) cells plated at day 3. There is a linear relationship between the number of spleen cells plated and the number of plaques formed. Plaque formation is inhibited by colchicine, actinomycin D, and rabbit anti-mouse globulin. This system offers a possible means for the direct in vitro measurement of the number of cells in a population susceptible to antigenic stimulation by sheep erythrocytes.


Age changes in the distribution of connective tissue elements in human material studies with polarized light microscopy.


A student-oriented learning center in the biomedical sciences.


Cells as antigen carriers and as immunoglobulin producers. Synthesis of antibody and allogeneic immunoglobulin after transfer of antigen-treated cells to newborn rabbits. The injection into newborn rabbits of a small quantity of human albumin, associated with red blood corpuscles or nucleated rabbit cells, induces an antibody response in the majority of animals, whereas the same quantity of antigen in solution fails to stimulate antibody formation or induces tolerance. The promoting capacity of the cells depends on attachment of antigen to them. The antibody produced after the injection of albumin, associated with nucleated cells, is of recipient origin. However, immunoglobulin carrying the marker of donor cells can be demonstrated in the recipient animals, and may reach serum concentrations similar to those normally present in animals which are heterozygous with respect to the marker. It appears that the antibody-promoting function and the synthetic capacity for allotype are quite distinct and that the period required for allotype formation is very short with mononuclear peritoneal exudate cells and is very much longer with cells from the thymus. The capacity of cells from lymph nodes for sustained allotype formation is less than that of thymus cells but greater than that of mononuclear peritoneal exudate cells.


Immunoglobulin metabolism.

Immunoglobulin metabolism.


Immunological unresponsiveness to specific antigenic determinants in human gamma-G globulin.


E. coli agglutinating activity of ulcerative colitis sera.


Stability of human immunoglobulin levels.


Experimental eosinophilia XI. Cell responses to particles of delineated size.


A rapid method for purification of large quantities of anti-lymphocytic serum.


Histochemical examinations of acid mucopolysaccharides in the mucosa of the seminal vesicles of castrated rats treated with gonadotropic hormones.


Origin of new crop of oocytes in Gobius giuris (Hamilton-Buchanan).


Pulmonary alveolar proteinosis. Origin of proteins in pulmonary washings.


Nemaline myopathy. A histopathologic and histochemical study.


Neurohistology of cystoid degeneration of the peripheral human retina.


Atresia of the intrahepatic bile ducts with xanthomatosis.


Lichen sclerosus et atrophicus and morphea.


Gonococcal skin lesions. Report of a case of gonococcal ecthyma.


Discoid lupus erythematosus in a newborn.


Effects of hyper- and hypoglycemia on beta cell degranulation and glycogen infiltration in normal, subdiabetic and diabetic rats.


Modern trends in the neurophysiological investigation of brain diseases. Introduction.


Cerebral metabolism, cerebral blood flow and EEG.


EEG and cerebral circulation-isotope technique.


Electroencephalograms and regional cerebral blood flow in cases of brain infarction.


Development of the rheoencephalographic investigation methods.


Thalamic unit activity in man.

Thalamic unit activity in man.


Technique and results of micro-electrode recording in human epileptogenic foci.


Changes in the form of cerebral evoked responses in man associated with various lesions of the nervous system.


Electrographic evidence of of participation of deep structures of the human brain in certain mental processes.


Modern trends in the neurophysiological investigation of brain diseases. Conclusion.


The EEG in stress. Physiological and psychological aspects. Introduction. The search for the mechanisms of the brain's reactions to stress.


The inhibitory control of spinal reflex action.


EEG of unrestrained animals under stressful conditions.


EEG changes in perceptual and sensory deprivation.


Electrical signs of association, expectancy and decision in the human brain.


Steady potentials in various stress conditions in man.


Some common features of the EEG changes associated with severe metabolic and other stress and their bearing on the problem of homeostasis.


EEG in children with loss of hearing.

EEG in children with loss of hearing.


The supraspinal control of transmission in spinal reflex pathways.


Morphological, electrophysiological and pathological aspects of interneurons.


Synaptic architecture of the spinal motoneuron pool.


Reflex pathways and synaptic connections in the vertebrate spinal cord in relation to pharmacological responses.


Diagnostic value of the electromyographic study of reflex activity in man.


EMG studies of stretch reflexes in man.

EMG studies of stretch reflexes in man.


Experiments concerning alleged pathophysiological function of human muscle stretch receptors.


Effects of age, consciousness, and other factors on human electrically induced reflexes (EIRs).


Functions of the spinal cord. Experimental and clinical aspects. Conclusion.


Maturation in vitro of human ovarian oöcytes.


Caries-resistant teeth.

Caries-resistant teeth.


Acute leukaemia.

Acute leukaemia.


Effect of adrenergic receptor blockade of the tachycardia of thyrotoxicosis and anxiety state.


Vitamin B12: an aid to oral mucous membrane healing.


Effects of irradiation and starvation on the regulation of rat liver enzymes.


Histochemical observations on Mycoplasma after staining with acridine orange. Mycoplasma colonies and Mycoplasma cells in preparations from infected milk and lymph nodes were observed for their fluorescent qualities after treatment with acridine orange. Mycoplasma colonies fluoresced brilliant red or red-orange. When treated after exposure to ribonuclease, the colonies fluoresced lime-green. There was no fluorescence when both ribonucleic acid and deoxyribonucleic acid were destroyed by perchloric acid. Detection of Mycoplasma in smears of mastitic milk or smears of infected lymph nodes was not definitive because of the large amount of nonspecific ribonucleic acid-rich material present during inflammatory reactions.


Study of the effects of experimentally induced endocrine insults upon pregnant and nonpregnant ewes. II. Normal adrenal and thyroid function, including responses to changes in environmental temperature.


Observational learning as a function of symbolization and incentive set.


Double alternation behavior as a function of age and language.


A vital stain for the specialized tissues of the heart.


A study on the adsorption of antibody by chopped guinea-pig lung and subsequent fixation of antigen.


Cleavage of gamma-M-globulin by means of reducing enzyme systems.


Insulin regulation of protein synthesis by muscle ribosomes: effect of the hormone on translation of messenger RNA for a regulatory protein.


A study of immunoglobulins in the blood serum of infants with interstitial plasma cellular pneumonia.


The effect of sodium ions on resting and action potentials in skeletal muscle fibres of Bombyx mori (L.).


Ionic composition of haemolymph and myoplasm in lepidoptera in relation to their membrane potentials.


Metabolism in the crayfish Astacus astacus (L). IV. --The fatty acid composition and the biosynthesis of the fatty acids.


Influence of a rapid change of temperature on the mechanical response of mammalian myocardium.


Studies on the potentiation of contractility of heart papillary muscle by paired stimulation.


The activity of the L-glutamic acid dehydrogenase.


A dual effect of a bifunctional alkylating agent on chymotrypsinogen.


Thyrotropin-like factor in a non endocrine cancer tissue.


Purification and properties of a non-specific hemagglutination inhibitor from human serum against picornaviruses.


Preparation and characterization of a sex-dependent rat urinary protein.


Fragmentation of human globulin with papain.


Proof of the hepatic synthesis of a sex-dependent protein in the rat.


The cortico-rubral projection in the cat.


Chemical and physical characteristics of urinary proteoses associated with streptococcal glomerulonephritis.


Further applications of thin-layer gel filtration: two-dimensional gel filtration-electrophoresis and immuno-gel filtration.


Effects of dietary phytol and phytanic acid in animals. Feeding of phytol in large doses (2-5% by weight in the diet) led to accumulation of phytanic acid in the mouse, rat, rabbit, and chinchilla, the degree of accumulation depending upon the level of dietary intake. The relative concentration of phytanic acid, expressed as a percentage of the total fatty acids, was as high as 20-60% in liver and 30-40% in serum. Phytenic acid, which may be an intermediate in the conversion of phytol to phytanic acid, also accumulated. When phytol was withdrawn from the diet, tissue and serum concentrations of phytanic acid fell rapidly, which indicates the ability of the normal animal to metabolize phytanic acid readily. At high dosages in the diet, phytol inhibited growth and caused death within 1-4 weeks. In the mouse, dietary phytanic acid and dietary phytol fed in equivalent amounts were of comparable toxicity. Accumulation of tissue phytanic acid occurred more rapidly when phytanic acid was fed than when phytol was fed in equal amounts. In none of the animals fed either phytol or phytanic acid were there any signs of neurological defects. Histologic examination of rats fed phytol showed some fat accumulation, glycogen depletion, and karyokinesis in the liver. There were no pathologic changes in the retina or in the peripheral and central nervous system such as those described in Refsum's disease.


A skin-sensitizing and thermolabile antibody in the mouse.


Reactions of anti-Gm(f) sera.

Reactions of anti-Gm(f) sera.


Genes and immunoglobulins.

Genes and immunoglobulins.


Linkage study of gamma globulin groups.

Linkage study of gamma globulin groups.


Increases in cortical depth and glia numbers in rats subjected to enriched environment.


Pa 1, a new inherited alpha-2-globulin of human serum.


Allotypic differentiation of rabbit gamma-globulins as a cause of posttransfusion shock.


Drug-induced haemolytic reactions due to antibodies against the erythrocyte/dipyrone complex.


The number of nerve cells in the cerebral cortex of man.


Anti-Gm and anti-globulinic antibodies after multiple pregnancies.


Definition of criteria for classification of oral cytologic preparations.


A study of Golgi preparations from the dorsal lateral geniculate nucleus of the adult cat.


Patterns of form and function in the central nervous system of Ariolimax.


A comparative study of the reticular formation of the guinea pig.


The demonstration of acid hydrolase, thermostable reduced diphosphopyridine nucleotide tetrazolium reductase and peroxidase activities in human lipofuscin pigment granules.


Characterization of enzymes hydrolyzing acylnaphthylamides. 3. Role of kynurenine formamidase.


Some comments on the mechanism of the Schiff reaction.


A histochemical and biochemical study of nuclear adenosine triphosphate hydrolysis in embryo heart.


Autoradiographic characterization of sulfated acid mucopolysaccharides in experimental cirrhosis.


Demonstration of catecholamines in adrenergic nerve fibers by fixation ii in aqueous formaldehyde solution and fluorescence microscopy.


Indole reactions of enterochromaffin cells and mast cells.


Standard smears for grading the content of acid-fast bacilli in sputum.


Disc electrophoresis (destaining, staining, protein recovery).


Structure of the common bile duct in man: presence or absence of smooth muscle.


Your slides: a visual aid or annoyance?

Your slides: a visual aid or annoyance?


The role of vitamin K in clotting factor synthesis. I. Evidence for the participation of vitamin K in the conversion of a polypeptide precursor to factor VII.


Infrared spectrophotometry its use in characterizing histochemical reaction mechanisms.


Drug-induced release and pharmacodynamic effects of histamine in the guinea-pig heart.


Intellectual abilities of symbolic and semantic judgment.


Selective staining of magnesium by titan yellow applied to incinerated tissue sections.


Methyl green-pyronin as a stain for autoradiographs of plant material.


An air-drying procedure for mammalian male meiotic chromosomes, following softening in gluconic acid and cell separation by an ethanol-acetic mixture.


Histological staining with two direct textile dyes: pontamine black RRX and pontamine fast black PGR.


Sieve cell differentiation; accurate determination by polarized light.


Durable mounts of the iodine stain for the phosphorylase reaction.


Two cases of progressive multifocal leuko-encephalopathy with unusual aspects.


A report on the FALG and trifalgic acid methods of staining.


Flotation-fluid staining; toluidine blue applied to maraglas sections.


Detection of viral antigen by autoradiography and immunofluorescence in epithelial cells of the respiratory tract in natural and experimental influenza infection.


A new silicone rubber duplicating material advantageous for teaching and research in physical anthropology.


Results of primary surgical treatment of 107 patients with carcinoma of the stomach.


Bleeding syndrome in a patient with IgA myeloma: interaction of protein and connective tissue.


Laboratory studies on a family with a father and son affected by acute leukemia.


The fine structure of neurons and synapses of the habenula of the cat with special reference to subjunctional bodies.


Persistence of Retzius-Cajal cells in developing dog brain.


Corticospinal fibers in the raccoon.

Corticospinal fibers in the raccoon.


Sulfur content of paper electrophoretic fractions in human serum.


The role of radiotherapy in the palliation of advanced bronchogenic carcinoma.


Study of modified bovine serum by gel filtration on pearl-condensed agar.


Serum protein changes after gastrectomy as a model of acute phase reaction.


Comparative peptide sequences of kappa and lambda chains of human immunoglobins.


Immunology: research at Mill Hill Institute.


Influence of superimposed nematode infection and grain supplement on some blood constitutents of calves on pasture.


Studies of the lipoprotein method used for detecting altered serum lipoproteins in equine infectious anemia.


Immunologic deficiency in Aleutian disease of mink.


The primary vesical sphincter.

The primary vesical sphincter.


Retropubic prostatectomy: a review with special reference to urinary infection.


Basal bodies of bacterial flagella in Proteus mirabilis. II. Electron microscopy of negatively stained material. This paper investigates further the question of whether the flagella of Proteus mirabilis emerge from basal bodies. The bacteria were grown to the stage of swarmer differentiation, treated lightly with penicillin, and then shocked osmotically. As a result of this treatment, much of the cytoplasmic content and also part of the plasma membrane were removed from the cells. When such fragmented organisms were stained negatively with potassium phosphotungstate, the flagella were found to be anchored-often by means of a hook-in rounded structures approximately 50 mmicro wide, thus confirming Part I of our study. In these rounded structures a more brilliant dot was occasionally observed, which we interpret as being part of the basal granule. A prerequisite for the demonstration of the basal granules within the cells was, however, the removal of both the cytoplasm and the plasma membrane from their vicinity. In some experiments, the chondrioids were "stained" positively by the incorporation into them of the reduced product of potassium tellurite. The chondrioids were here observed to be more or less circular areas from which rodlike structures extended. The chondrioids adhered so firmly to the plasma membrane that they were carried away with it during its displacement by osmotic shocking, while the basal bodies were left behind. This observation disproves our previous suggestion that the flagella might terminate in the chondrioids. The basal bodies often occur in pairs, which suggest that they could be self-reproducing particles.


Loss of the zona pellucida in mice, and the effect of tubal ligation and ovariectomy.


The detection of antibodies to spermatozoa and to blood group antigens in cervical mucus.


A method for the direct observation of ovulation inhibition in the mature rat.


A mobile intensive-care unit in the management of myocardial infarction.


Prognosis after recovery from ventricular fibrillation complicating ischaemic heart-disease.


Myopathy remitting in pregnancy and responding to high-dosage oestrogen and progestogen therapy.


Gas endarterectomy. Techniques, applications, and initial results.


Jugular bulb creatine kinase as an indication of slight transient brain damage.


Migraine without headache.

Migraine without headache.


Suppression of lactation by stilboestrol.


Puerperal thromboembolism and suppression of lactation.


David and Goliath.

David and Goliath.


Cerebral vulnerability to ischaemia.

Cerebral vulnerability to ischaemia.


The long arm of the M.R.C.

The long arm of the M.R.C.


Treatment of hepatic COMA.

Treatment of hepatic COMA.


Thrombosis and suppression of lactation.


Booms.

Booms.


Spinal neurofibromas.

Spinal neurofibromas.


Salmon disease.

Salmon disease.


Choice of antibiotic.

Choice of antibiotic.


St. Christopher's Hospice.

St. Christopher's Hospice.


Specialist medicine within the European community.


Shedding of bacteria to the air from contaminated towels in paper sacks. Possible significance for operating-rooms.


Adaptation of an avian arthritis viral agent to tissue culture.


Influence of methylproline isomers upon actinomycin biosynthesis.


Histological changes in the bovine mammary gland after infusion with Streptococcus agalactiae extract.


Fluorescein staining of guinea-pig lymphocytes induced by Echis colorata venom.


The occurrence of Pseudomonas in the reproductive tract of mares and its effect on fertility.


Cytophotometric investigations on the influence of heavy water upon the nucleic acid content of tumour cells.


A useful new stain for electron microscopy.


Effect of short-term fasting on thyroid activity of cattle at various environmental temperatures.


An electron microscopy study of vitally stained single cells irradiated with a ruby laser microbeam. An electron microscope study has been made of vitally stained single cells whose cytoplasm has been subjected to a localized ruby laser microbeam. Light and moderate laser absorption (the resultant of stain concentration and laser energy density) produced restricted selective damage of mitochondria in cells stained with Janus green B; heavy laser absorption resulted in mitochondrial damage, as well as in nonselective interaction with other cell structures. With four other basic vital stains, the polysomes, ergastoplasm, mitochondria and other organelles at the irradiated site were uniformly damaged. Unstained cells showed no morphological alterations. With light primary damage (that restricted to the irradiation site), no secondary effects of the incident radiation were observed. With moderate primary damage, however, secondary damage of the mitochondria in the unirradiated cell portions was produced, which was reversible within 4 hr after irradiation. Heavy primary lesions caused severe secondary alteration of all cell structures that was irreversible and cell death occurred within 2 hr. Surviving cells examined 24 hr after light and moderate irradiation could not be distinguished from unirradiated controls. The possible mechanisms involved in the production of laser-induced cellular alterations are discussed.


Progressive serum protein changes in turkeys infected with Histomonas meleagridis.


An electron microscopic study of the interaction of macroglobulin (IgM) antibodies with bacterial flagella and of the binding of complement.


Passive anaphylactic reaction in mouse peritoneal mast cells in vitro.


Identification of the agent responsible for the abnormal immunoelectrophoretic pattern of serum in Duchenne's progressive muscular dystrophy.


Immunoelectrophoretic investigations of the serum of carriers of Duchenne's progressive muscular dystrophy.


Comparison of the C-terminal amino-acid sequence of two horse immunoglobulins IgG and IgG(T).


Proteinuria in patients with homotransplanted kidneys.


Interactions of narcotics and their antagonists with human serum esterase. II: nature of the antagonism.


Interactions of narcotics and their antagonists with human serum esterase. I: sites of action and nature of the inhibitory effect.


Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group.


Some properties of proline-sRNA synthetase from rat liver.


Generation of reducing power in chemosynthesis. IV. Energy-linked reduction of pyridine nucleotides by succinate in Thiobacillus novellus.


Changes in electrophoretic migration due to impregnation of the paper strips with various buffers.


Changes in electrophoretic migration due to impregnation of the paper strips with non-buffer solutions.


The use of cellulose acetate for the electrophoretic separation and quantitation of serum lactic dehydrogenase isozymes in normal and pathologic states.


Huckleberry Finn. A psychoanalytic study.


A psychoanalytic study of the Marschallin theme from der Rosenkavalier.


The effect of long-term phenindione treatment on thyroid function.


Totally synthetic steroid hormones. XII. The preparation and catalytic hydrogenation of novel plus or minus-estra-1,3,5(10),8,14,16-hexaenes and plus or minus-13-ethylgona-1,3,5(10),8,14,16-hexaenes.


Detection of uridine 3'-ethyl phosphate and homologues in digests of ribonucleic acid hydrolyzed with pancreatic ribonuclease in the presence of traces of ethanol.


Hypothalamic stimulation and the inhibition of the activity of cardiac sympathetic and parasympathetic nerves.


DNA metabolism in perfused organs. II. Incorporation into DNA and catabolism of thymidine at different levels of substrate by normal and x-irradiated liver and intestine.


Prevention of RH haemolytic disease. A method based on the post-delivery injection of the mother with anti-D antibody.


ATP+ca++-linked contraction of red cell ghosts.


Specific binding of gamma-G globulin to erythrocytes.


Biosynthesis of the fatty acids in aseptically reared larvae of the blowfly Calliphora erythrocephala (Meig.).


Letter to the editor. Classification of immunoglobulins.


The purification of human placental plasminogen (profibrinolysin).


Pontine triggering of phasic changes in sensory transmission during deep sleep.


External standardization in homogeneous liquid scintillation counting of H3, C14, and P32, singly or in combination.


Suppressor sensitive mutants of the RNA phage MS-2.


Pernicious anemia. II. Immunological studies.


Does propyl-thio-uracil have extra-thyroidal effects in man?


Gastric pepsin, mucus and clinical secretory studies. II. The role of the mucous barrier in the defense of the stomach vs. peptic ulceration. Carbohydrate histochemistry of gastric epithelial secretions in dog.


Evaluation of drug therapy in chronic diseases.


Reaction of dissociated IgM anti-gamma-globulins with rabbit immunoglobulin G (IgG).


Immunoglobulins in serum and nasal secretions following infection with type 1 parainfluenza virus and injection of inactivated vaccines.


Immunologic responses in the axolotl, Siredon mexicanum.


"Protein A" from Staphylococcus aureus. 3. Reaction with rabbit gamma-globulin.


Allelic light chain allotype distribution in purified IgG and IgM rabbit antibodies.


Selective immunoglobulin deficiencies in rats infected with Moloney virus.


Human diphtheria antitoxin in immunoglobulin classes IgG and IgA.


Biologic activities of aggregated gamma-globulin. 8. Aggregated immunoglobulins of different classes.


Mechanisms of immunologic injury of rat peritoneal mast cells. 3. Cytotoxic histamine release.


Differential synthesis of bacteriophage-specific proteins in MS2-infected Escherichia coli treated with actinomycin.


Serum protein-bound iodine and phenylketonuria.


Hematologic alterations in pregnant rheusus monkeys.


Immunosuppressive therapy. The relation between clinical response and immunologic competence.


Cytoplasmic: nuclear ratios of epithelial cells in oral aspirates.


Histidine and keratohyalin granules.

Histidine and keratohyalin granules.


A stain for sweat pores.

A stain for sweat pores.


Antibiotics and infectious serositis in White Pekin ducklings.


The homogeneous-gamma-G-immunoglobulin produced by mouse plasmacytoma 5563 and its subsequent heterogeneity in serum. The mouse plasma cell tumour 5563 has been shown to synthesize and secrete a single molecular species of gammaG-immunoglobulin, which was identified by labelling with (14)C-labelled amino acids. The heterogeneity of G-myeloma globulin as it is found in serum of tumour-bearing mice is due to subsequent changes in the charge properties of the newly secreted molecules. These changes have been reproduced in vitro. On incubation with sterile serum, the newly formed radioactive myeloma protein changed its chromatographic and electrophoretic properties to coincide with those of myeloma protein isolated from serum. Incubation of purified myeloma protein band a, under a variety of conditions, led to the characteristic pattern of serum myeloma protein showing multiple electrophoretic bands. The chemical nature of the molecular changes is not yet known. It is suggested that seruminduced changes could contribute to the electrophoretic heterogeneity of specific antibodies within the gammaG-class of immunoglobulins. This demonstration of the production of a single molecular species of immunoglobulin by a plasma cell tumour provides support for the concept of ;one-cell-one antibody'.


Detection of intracardiac thrombi using radio-iodinated antifibrinogen (RIAF) and precordial scanning: experimental and clinical studies.


Studies on the oral administration of saliva-parotin-A. IV. Oral and intraintestinal administration of 131-I-labelled saliva-parotin-A to rats.


Production and use of silver-coated radioactive gold colloids.


Studies on the proteolytic activity of gamma-globulin preparations. 1. The proteolytic activities of several gamma-globulin preparations were tested. These included sulphate-precipitated human and bovine preparations and human and bovine Cohn fraction II preparations as well as purified gamma-globulin preparations. Up to 14mg. of diffusible peptides and glycopeptides/g. of gamma-globulin was liberated after dialysis and up to 10mg. of peptides/g. after incubation and trichloroacetic acid precipitation, as products of the degradation process in incubated gamma-globulin. 2. in-Aminohexanoic acid and p-chloromercuribenzoic acid, as well as heating at 60 degrees for 40min., were shown to inhibit strongly these proteolytic activities. Streptokinase was shown to activate strongly the proteolytic activity of all the human preparations (sulphate-precipitated, Cohn fraction II, and purified gamma-globulin). 3. Two distinct pH optima were shown for human and bovine gamma-globulin preparations: one at pH8, the other at pH3.8 (the latter activity could be demonstrated only in the presence of cysteine). 4. Both (131)I-labelled human Cohn fraction II and bovine fibrinogen were attacked by a sulphate-precipitated preparation of gamma-globulin. Of the synthetic substrates tested toluene-p-sulphonyl-l-arginine methyl ester was hydrolysed by both the sulphate-precipitated and Cohn fraction II preparations, as was benzoyl-l-arginine amide at pH5, but only in the presence of cysteine. 5. These data are interpreted to indicate that at least two enzymes are present in gamma-globulin preparations, one being similar to the plasmin system, the other similar to cathepsin B.


A delayed prolonged increase in venular permeability following intrapleural injections in the rat.


Studies on the oöthecal protein of the tortoise beetle, Aspidomorpha.


Decalcified fossil dentine.

Decalcified fossil dentine.


The changing pattern of air pollution in the United States.


Influence of DNA on growth and viability of transformable group H streptococci.


An outbreak of Tunga penetrans in a pig herd.


Oscar Gilje (1903-1966).

Oscar Gilje (1903-1966).


The mononuclear-cell infiltrate in allergic contact dermatitis. 1. Participation of thymic cells.


The effect of dimethyl sulfoxide on the percutaneous absorption of mercuric chloride in the guinea pig.


Comparison of steroids in topical treatment of psoriasis.


Cellular changes in the psoriatic epidermis. V. The submicroscopic intracellular distribution of mercury compound in the psoriatic epidermis.


Culture of adult human epidermal cells obtained from roofs of suction blisters.


Cryoglobulins and rheumatoid factor in systemic lupus erythematosus.


Cryoglobulins and rheumatoid factor in sera from chronic false positive seroreactors for syphilis.


Plantar pseudochromohidrosis simulating malignant melanoma.


Extramammary Paget's disease.

Extramammary Paget's disease.


Pseudoxanthoma elasticum with a knuckle pad on the thumb.


Scabies Norvegica.

Scabies Norvegica.


A histochemical study of the granulocyte zinc content in cutaneous neoplasia and in skin reactions to internal malignancy.


The effect of temperature on the glucose utilization by Bacillus stearothermophilus.


The influence of aliphatic saturated dicarboxylic acids on Ashbya gossypii. I. Growth and riboflavin synthesis.


The influence of aliphatic saturated dicarboxylic acids on Ashbya gossypii. II. Polarographic investigations.


Helena Krzemieniewska 1878-1966.

Helena Krzemieniewska 1878-1966.


The itaconic and itatartaric acid formation by UV and gamma irradiated isolates of Aspergillus terreus NRRL 1960.


The activity of lactate, succinate and malate dehydrogenase in staphylococci.


Etiology of some bacterial diseases of poplar in Poland. I. Bacteriosis caused by Pseudomonas Migula and Erwinia Winslow.


Particle size of the severe strain of bean yellow mosaic virus. Electron microscope investigations.


Transduction in Rhizobium meliloti.

Transduction in Rhizobium meliloti.


Modified procedure for the microscopic and macroscopic study of viral plaques. A virus plaque method that consistently gives good visual contrast for macroscopic observation and also permits microscopic study is described. Cells are grown in plastic flasks and the gelled overlay medium can be of any desired agar concentration or volume. A fixing solution is used prior to removal of the agar overlay, and dye is added to the fixing solution or staining can follow fixation and agar removal. The bottom of the flask with the fixed monolayer is separated from the rest of the container and handled as a slide. A new mounting medium is described.


Variations of human plasma and serum viscosities with their protein content.


Antibiotic sensitivity of Micrococcus radiodurans. A wild-type strain of Micrococcus radiodurans and its nonpigmented mutant W(1) were tested for sensitivity to 10 antibiotics selected from the standpoint of their mechanism of action. Representatives of groups of antibiotics inhibiting deoxyribonucleic acid (DNA) synthesis, DNA-dependent ribonucleic acid synthesis, protein synthesis, and cell wall synthesis were selected. M. radiodurans and its mutant exhibited full susceptibility to all antibiotics tested (mitomycin C, actinomycin D, chloramphenicol, dihydrostreptomycin, erythromycin, neomycin, kanamycin, benzylpenicillin, bacitracin, and vancomycin), the degree of susceptibility being of the same order as that of a standard strain of Staphylococcus aureus 209 P, with the exception of dihydrostreptomycin.


Morphologic aspects of vascular permeability to fat.


Stroboscopic reflected dark-field cinemicrography: pulmonary fibrination (as in maternal abruptio placentae) versus meconium embolism (as in amniotic embolism).


Effect of digitonin and digitoxin on the phospholipid metabolism of mammalian tissue culture cells.


Inhibition of catechol-O-methyl transferase by some acid degradation products of adrenaline and noradrenaline.


The preparation of ferritin-labelled antibodies and other protein-protein conjugates with bis-diazotized benzidine.


Transport of narcotic analgesics by choroid plexus and kidney tissue in vitro.


Ratios of the Fab fragments I and II from rabbit antibodies and non-specific gamma-globulins.


Precipitation of some plasma proteins by the addition of dextran or polyethylene glycol.


The effect of alpha-2-macroglobulin in human serum on trypsin, plasmin, and thrombin activities.


Anatomical organization of the brachial spinal cord of the cat. II. The motoneuron plexus.


Anatomical organization of the brachial spinal cord of the cat. I. The distribution of dorsal root fibers.


Monoamines in the subfornical organ.

Monoamines in the subfornical organ.


Dream form and strength of impulse in dreams of falling and other dreams of descent.


Crystallographic study of rabbit Fc. I. A comparison of crystals from different allotypes.


An investigation of the induction of beta-galactosidase in a broken spheroplast preparation of Escherichia coli.


Diagnostic value of serum-creatine-kinase in coronary-care unit.


Simple test to determine the site of urinary-tract infection.


Long-term treatment of multiple sclerosis with corticotrophin.


Hydrocortisone metabolism in rheumatoid arthritis.


Myocardial infarction in a patient with a circulating anticoagulant.


Peritoneal dialysis in acute renal failure following malaria.


Neonatal death associated with isovalericacidaemia.


Urinary steroid and gonadotrophin excretion in women following long-term use of oral contraceptives.


Psychosis associated with the use of a sequential oral contraceptive.


The effect of crude secretin in maturity-onset diabetes mellitus.


Effect of clofibrate on platelet economy in man.


Adrenal steroids and haemolysis in paroxysmal nocturnal haemoglobinuria.


Hydroxocobalamin versus cyanocobalamin in the treatment of tobacco amblyopia.


Crystalline bodies in lymphocytes of patients with Down's syndrome.


A school in Wessex.

A school in Wessex.


Hazards of immunisation.

Hazards of immunisation.


Alcoholic cardiomyopathy.

Alcoholic cardiomyopathy.


Killed-measles-virus vaccine.

Killed-measles-virus vaccine.


Origin of Kaposi's sarcoma from the reticulo-endothelial system.


Fractionation of beef liver ribosomes with specific antiserum.


Investigations on ceruloplasmin in chronic schizophrenia.


Cell types in the pituitary of the eel, Anguilla anguilla L., at different stages in the life-cycle.


Changes in the dermis of human hairy skin resulting from stripping the keratinized layer off the epidermis.


Spider phobias.

Spider phobias.


Epithelial-cell reutilization of nuclear material and selective accumulation of lymphoid cells in allergic contact dermatitis.


Symbolism of the umbrella.

Symbolism of the umbrella.


Itch duration in the involved skin of atopic dermatitis (prurigo Besnier).


Suction blisters in the study of cellular dynamics of inflammation.


Delayed dermal and epidermal reactivity in atopic dermatitis (prurigo Besnier). I. Delayed reactivity to bacterial and mold allergens.


Delayed dermal and epicutaneous reactivity in atopic dermatitis (prurigo Besnier). II. Epicutaneous reactivity in atopic dermatitis.


Cell transformation and mitogenic effects in blood leucocyte cultures of atopic dermatitis patients.


Tape-stripping method for cytological diagnosis of mycosis fungoides.


Lysosomes and acantholysis in human skin.


Onychomycosis caused by Phyllostictina Sydow.


Do results of culture for gonococci vary with sampling phase of menstrual cycle?


Iron metabolism and anaemia in systemic lupus erythematosus and rheumatoid arthritis.


Studies on the structural and biological nature of the aster associated metachromatic granules in sea urchin eggs by means of light and electron microscopy.


Mast cells in the lymphnode sinus of the rat.


Supravital staining of mitochondria with Illuminor R.


A Bouin-lead acetate mixture for the cytological study of pancreatic islets in aldehyde fuchsin-trichrome stain.


Beta-mercaptoethylamine and cystamine-induced histamine release in the dog.


Kinetics of lymphocyte proliferation in the immune response.


Plasma cells in the human thymus.

Plasma cells in the human thymus.


Homologies in the position of cysteine residues of K and L type chains of human immunoglobins.


Products of the peptic digestion of human gamma-G-immunoglobulin.


Variability in the specific interactions of H and L chains of gamma-G-globulins.


Disk electrophoresis of isolated rat-serum lipoproteins.


Subfractionation of rat serum low density lipoproteins.


A staining procedure for demonstration of multiple forms of aldolase.


Two structurally different types of rabbit light chains.


Isolation and characterization of rabbit colostral IgA.


Peptide differences in purified mouse antibodies.


Localization of immunoglobulins in human nasal mucosa.


An agarose-gel zone electrophoresis technique for in-vivo protein binding studies of radio-active isotopes.


Comparison of DNA revealed by Feulgen and by ultra-violet light in rabbit spermatozoa after storage in the male efferent ducts.


Failure of function of the "early protein" induced by an influenza virus in cells infected by Newcastle disease virus.


Rheumatoid arthritis as an antiatheromatous syndrome.


Tissue reactions in experimental animals caused by atypical mycobacteria--evaluation of pathogenicity. I. Early reactions.


Renal histology in 30 cases of isolated proteinuria. Frequency of hyaline and fibrinoid deposits in renal arterioles.


Occurrence of virus-like bodies in transplantable vaginal neoplasms in mice.


I.S.R.R.T.--teachers' seminar, London, 1966.


The effect of endoxan, hydrocortisone and antistine on cell metabolism in tissue culture in vitro.


Incidence and forms of leukaemia among the Congolese Bantus.


Intracutaneous fluorescent antiglobulin test in patients with systemic lupus erythematosus.


The immunological value of the mast cell disruption--inhibition test.


The transformation of human mononuclear leukocytes in vitro. II. Precursors of large mononuclear cells on coverslips.


Agglutinin synthesis regulation independent of antigen.


Metabolism of bovine immunoglobulin. I. Metabolism of bovine IgG in cattle with chronic pyogenic infections. Isolation of IgG-slow by anion exchange chromatography is described. The turnover of IgG-I(131) has been studied in 10 cows, 5 of which were hyperimmunoglobulinemic, i. e. with serum immunoglobulin levels above 3.0gm/100 ml. These hyperimmunoglobulinemias were caused mainly by pyogenic infections. When these cows were compared with 5 normoimmunoglobulinemic cows the salient turnover data were, high fractional turnover rates, short plasma half lives, low Ev:Iv ratios and extended plasma volumes (table I). The results are discussed in relation to similar findings in other animal species and man. Possible mechanisms of the observed hypercatabolism are outlined.


A study of porcine enteroviruses isolated from swine in the Toronto area. II. Characterization of the viruses as members of the picornavirus group. Five antigenic types of enteric viruses from swine in the Toronto area were characterized as members of the enterovirus subdivision of the picornavirus group. The criteria used in the characterization of these viruses were those established by the International Enterovirus Study Group.


Altered complement component C3A (beta-1C--beta-1A) in patients with glomerulonephritis.


Compleat immunology: science or septophrenia?


Scleroderma treated with the diethylaminoethylester Hydriodide salt of Penicillin G.


Further studies on use of polymyxin B sulfate with dihydrostreptomycin and penicillin for control of Vibrio fetus in a frozen semen process.


Experimental skeletal tuberculosis in the guineapig. A method for producing local lesions and an autoradiographic study of their accessibility to tritium-labelled dihydrostreptomycin.


Proteins of the human prostate tissue as characterized by electrophoresis, immunodiffusion and immunoelectrophoresis in agar gel, combined with histochemical staining methods.


The identification and delineation of myocardial infarcts.


Histochemistry of thyroid tumors. Significance of two enzymes and PAS-positive materials.


Observations on the distribution of the proteinpolysaccharide complex and collagen in bovine articular cartilage.


The effect of various chemotherapeutic agents on Sarcoma 37 ascites tumor cells.


On the use and abuse of the critical electrolyte concentration approach to the localization of tissue polyanions.


Metal salts-hematoxylin staining of skin keratohyalin granules.


Method for urinary cytology in endocrine assessment.


The effect of the immune tolerant state on early behaviour of domestic fowl.


"Silent educator" promotes understanding, home care.


Functional bite technique in fixed bridge construction.


Advantages and limitations of oral exfoliative cytology.


ADA proposes new program for dental laboratory technicians.


Immune mechanisms for destruction of erythrocytes in vivo. I. The effect of IgG rabbit antibodies on rat erythrocytes.


Dr. Cooper honored.

Dr. Cooper honored.


Penn gets grant 7,500,000 dollars for development of Center for Oral Research.


Squamous cell carcinoma of the floor of the mouth and the alveolar process.


The basic requisites of all occlusions.

The basic requisites of all occlusions.


Dental education for the future.

Dental education for the future.


Immune mechanisms for destruction of erythrocytes in vivo. II. Heparinization for protection of lysin-sensitized erythrocytes.


Patient silent educator.

Patient silent educator.


The use of sialography in diagnosis.

The use of sialography in diagnosis.


I. Focus on tomorrow. Health science education in the space age.


Focus on the future: communications and health in tomorrow's community.


The need for vision.

The need for vision.


The challenge of change.

The challenge of change.


The still image.

The still image.


The use of 8 mm loop films in individualized instruction.


The Public Health Service Audiovisual Facility.


A new public antigenic determinant Gya (Gregory).


Serum protein-bound iodine levels in adolescents.


Studies on a unique diagnostic serum globulin in papular mucinosis (lichen myxedematosus).


Kappa chain cold precipitable immunoglobulin G (IgG) associated with cold urticaria. I. Clinical observations.


Wiskott-Aldrich syndrome: review and report of a large family.


Consequences of neonatal thymectomy in New Zealand black mice.


Immune hemolysis: a simplified method for the preparation of EAC'4 with guinea pig or with human complement.


False positive radio-immunoautograph lines associated with immunoglobulins from normal sera.


Production of immunoglobulins and their subunits by human tissue culture cell lines.


Studies on human lymphocytes in vitro. IV. Comparative fine structural features of the established Burkitt lymphoma cell lines AL-1, EB-2 and phytomitogen-transformed lymphocytes.


Plasma protein constituents of amyloid fibrils.


The effect of antigenic competition on antibody production to heterologous proteins, termination of immunologic unresponsiveness and induction of autoimmunity.


Notation for human immunoglobin subclasses.


Pharmacological investigations of some bis-quaternary ammonium salts of NN-bis-(aminoacylo)piperazine derivatives. II. Influence on cholinergic system, cholinesterase activity and histamine liberation.


Short neurons and their synaptic relations in the specific thalamic nuclei.


Inability of anti-insulin serum to neutralize insulin after the hormone has become bound to muscle.


Prevention of rhesus iso-immunisation disorder of the newborn.


Silver impregnation of degenerating dendrites, cells and axons central to axonal transection. I. A Nauta study on the hypoglossal nerve in kittens.


The role of the thyroid and food intake in the ageing of collagen fibres. I. In the young rat.


Use of zinc ions for fractionation of pig gamma-G-globulin and its structural subunits.


Thyroid activity and heat production in cattle following sudden ambient temperature changes.


Tissue dynamics of steady state growth in Hydra littoralis. II. Patterns of tissue movement.


Structure and anticoagulant activity of bridge-substituted dicoumarols.


Intramitochondrial transformations during oocyte maturation in the mouse.


The microscopic structure of the adult raccoon (Procyon lotor) and woodchuck (Marmota monax) spleens.


Stimulus characteristics and spatial encoding in sequential short-term memory.


Novel alterations in sera from pseudopregnant and deciduoma-bearing rats.


Recognition of altered autologous constituents as foreign by phagocytic cells.


Mycoplasma hominis in Ayre's smears.

Mycoplasma hominis in Ayre's smears.


Chromosomal composition of HeLa and L cells in tissue cultures.


Osmotic resistance of leucocytes in irradiated patients with slightly advanced malignant tumours.


Tentative clinical application of tetramezyl-mannitol (R52).


The frequency of Kappa and Lambda chains in pathologic serum gamma-G, gamma-A, gamma-D and gamma-mu immunoglobulins.


A phloxine-azure-hematoxylin sequence for differential staining of cells in pancreatic islets.


Double staining for comparative measurements in squash preparations.


A glutaraldehyde-dichromate-silver sequence for differentiating norepinephrine cells from epinephrine cells in neonatal and adult rats--paraffin sections.


Toluidine blue O and naphthol yellow S; a highly polychromatic general stain.


A Romanowsky-type stain for canine blood; phloxine and rose bengal used in place of eosin.


A modified Dominici technic for autoradiography: acidified eosin-orange and alcoholic toluidine blue.


Progressive familial myoclonic epilepsy with Lafora bodies. Electron microscopic and histochemical study of a cerebral biopsy.


Possible medical factors contributing to the fatal crash of a race pilot: a case report.


Thioflavin S fluorescent and Congo red anisotropic stainings in the histologic demonstration of amyloid.


Serological studies of parasitized cattle. II. Electrophoretic properties of serial serum samples. Electrophoretic examinations using cellulose acetate strips were made on 17 serum samples collected at two-week intervals from each of three calves before and for about four months after they were placed on parasite-infected pastures in June, 1964. Four additional serum samples taken during the winter months when the animals were stabled and two obtained after they were again exposed to infected pastures in June 1965, were also examined. Two control animals of the same age, that were placed on clean pasture in 1964 and not exposed to infected pasture until June 1965, were bled on the same dates and their sera examined in parallel. All five calves showed an increase in the proportion and amount of gamma-globulin in their serum as they increased in age but the gain was greatest in the two exposed calves that developed the highest complement-fixing titres with nematode antigens. Complement-fixing titres rose slowly in the other exposed calf and its serum gamma-globulin level remained relatively comparable to that of the two controls.


DNA content and size of sex chromatin positive female nuclei during the cell cycle.


Barr bodies in relation to DNA values and nuclear size in cultured human cells.


Immunofluorescent and immunophoretic data on antigenic properties of Candida albicans.


The routine determination of polycyclic hydrocarbons in airborne pollutants.


Electron microscopic demonstration of dehydrogenase activity with a new osmiophilic ditetrazolium salt (TC-NBT).


The Krebs in glomeruli of normal rat kidney and in compensatory hypertrophy.


Structural homologies in immunoglobulins.


The effect of adrenaline and noradrenaline on hormone secretion and blood flow from the thyroid vein in sheep with exteriorized thyroids. 1. Emotional stimulus to the sheep has previously been shown to cause increased thyroid hormone secretion; the influence of adrenaline and noradrenaline in this process has been investigated.2. Sheep bearing exteriorized thyroid glands on carotid artery-jugular vein loops were used. Thyroid vein blood was collected through a cannula in the jugular vein within the loop, and blood flow was measured by a plethysmographic technique.3. (131)I (50 muc) was injected intramuscularly (I.M.) into the sheep, and 4-7 days later the concentration of total and protein bound (131)I in thyroid vein blood was measured in samples taken every 10 min for 4 hr. Intracarotid injections of 1 mug, I.V. injections of 5 mug, or I.V. infusions at 10 mug/min for 10 min, of adrenaline or noradrenaline were administered 1.5 hr after commencement of sampling. Blood flow from the thyroid was measured in similar experiments.4. No significant changes in thyroid hormone secretion could be attributed to adrenaline or noradrenaline, and it was concluded that circulating catecholamines do not influence the release of thyroid hormone observed after brief emotional stimulus in the sheep.


Propagation of mammalian viruses in Protista II. Isolation of complete virus from yeast and Tetrahymena experimentally infected with picorna viral particles or their infectious RNA.


Dual localization of beta-glucuronidase in endoplasmic reticulum and in lysosomes.


Immune response to substituted arsanil-azo-human gamma globulin conjugates in mice tolerant to human gamma globulin.


Immunoelectrophoretic analysis of serum proteins of patients affected by kala-azar.


Observations on adult polynuclear leukocyte nucleus stained with basic dyes.


On the ultrastructure of leukemic monocytes.


Cerebellifugal fibres to the cochlear nuclei and superior olivary complex.


Method for staining both acid-fast and chromophobic tubercle bacilli with carbolfuschsin.


Phosphate uptake in an obligately marine fungus. II. Role of culture conditions, energy sources, and inhibitors. Phosphate uptake in the obligately marine fungus, Thraustochytrium roseum, is maximal at pH 7.5 to 7.8, is dependent on temperature, and varies with phosphate concentration. Pyruvate and succinate stimulate phosphate uptake, although they do not increase respiration. The uncoupling agents, 2,4-dinitrophenol and dicoumerol, inhibit phosphate uptake but stimulate oxygen consumption only in the presence of NaCl. Oligomycin inhibits both processes. Among the inhibitors of protein synthesis, chloramphenicol reduces phosphate uptake without affecting respiration. Puromycin is unique in that it greatly enhances phosphate uptake and abolished the lag period associated with this phenomenon. It does not affect respiration.


An exposure control for the Kodak Carousel Model 700 projector.


306 cases of toxic adenoma: clinical aspects, findings in radioiodine diagnostics, radiochromatography and histology; results of 131-I and surgical treatment.


Abnormal chromatographic pattern of gamma-globulin in acute rheumatoid arthritis.


Methods of forced diuresis and its application in barbiturate poisoning.


Acute lymphoblastic leukaemia treated with a combination of prednisone, vincristine, and rubidomycin. Value of pathogen-free rooms.


Spirometry and blood-gas tensions in bronchial asthma and chronic bronchitis.


Cardiac failure in kwashiorkor.

Cardiac failure in kwashiorkor.


Persistence of virus in lens for three years after prenatal rubella.


Plasma-levels of glucose, non-esterified fatty acid, glycerol, and insulin four years before the onset of diabetic ketosis.


Trials of five antibacterial creams in the control of nasal carriage of Staphylococcus aureus.


Cerebral-cortex perfusion-rates in extracranial cerebrovascular disease and the effects of operation.


Transcortin in the plasma of patients with breast cancer.


Radiologically undetectable pulmonary collapse in the supine position.


Bilateral renal calculi and aminoaciduria after excessive intake of Worcestershire sauce.


A simple device to immobilise infants.

A simple device to immobilise infants.


Treatment of hyperthyroidism.

Treatment of hyperthyroidism.


Anticoagulant treatment for myocardial infarction.


The only way.

The only way.


Leukaemoid reactions.

Leukaemoid reactions.


Huntington's chorea.

Huntington's chorea.


This villainous saltpetre.

This villainous saltpetre.


Tuberculosis and pneumoconiosis.

Tuberculosis and pneumoconiosis.


A course in psychology and sociology for medical students.


Hypersensitivity to ampicillin and tetracycline.


Douglas McClean.

Douglas McClean.


Differentiation of synaptic bulbs in Clarke's column.


Cytomegalovirus type cytopathic changes in spontaneously degenerating human embryonic cell cultures.


Abolition of passive immunity to bacterial infections by iron.


Problems of the origin of the anodic part of cerebrospinal fluid gamma-G-globulins in infalmmatory affections of the central nervous system.


Evidence for the placental transfer of tri-iodothyronine in human beings.


Immunoglobulin synthesis by the human fetus.


A correlative immunologic, microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants.


Transplacental passage of thyroid hormones.


Histochemical studies of canine renal homotransplants with special reference to alkaline phosphatase and its isoenzymes.


Experimental renal heterotransplantation. 3. Passive transfer of transplantation immunity.


Lack of demonstrable IgG in phytohaemagglutinin-stimulated human transformed cells cultured in a serum-free medium.


Treatment of renal homografts with local graft radiation and actinomycin C or D.


AN UNIQUE TYPE OF AXONAL ALTERATION (so-called axonal dystrophy) as seen in Goll's nucleus of 277 cases of controls. A contribution to the pathology of aging process.


Mitotic activity in epithelial rests of Malassez.


The proteins and protein-bound carbohydrates of the serum of the developing pig. 1. The concentrations of total nitrogen, hexosamine and protein-bound hexose and the amounts of these constituents precipitated by trichloroacetic acid were determined in the serum of pigs at various ages from 57 days after copulation to 42 days after birth. The concentrations of the same constituents were also determined in the serum of mature pigs. 2. A rise in the concentrations of total nitrogen, hexosamine and protein-bound hexose between 90 days' gestation and term was entirely due to material soluble in trichloroacetic acid. This material disappeared from the serum by 7 days after birth. 3. Electrophoresis of the serum proteins showed that the concentration of alpha(1)-globulin fell steadily during gestation, being lower at term than at 57 days' gestation. No alpha(1)-globulin was detected at 7 days of age. 4. It was concluded that high values for non-protein nitrogen in the serum of newborn piglets, determined after precipitation of the proteins with trichloroacetic acid, is largely due to the presence of one or more mucoproteins and not to alpha(1)-globulin. 5. The protein migrating in the alpha(1)-globulin position is possibly a foetal protein of the fetuin type.


Acid mucosubstance and basic protein in mouse Paneth cells.


The use of phenazine methosulfate for improving the histochemical localization of ketose reductase (L-iditol:NAD oxidoreductase, or sorbitol dehydrogenase).


The effect of endogenous antibody on insulin-assay in the newborn infants of diabetic mothers.


On the presence of gamma G and beta-1 C globulins in renal glomeruli of aging and neonatally x-irradiated mice.


Systemic neuroaxonal dystrophy in Suffolk sheep.


Immunogenetic studies on mongolism.

Immunogenetic studies on mongolism.


Performance of institutionalized mental retardates on the M-F Symbol Sort.


Continuous automatic determination of sulfur dioxide in the presence of auto engine exhaust.


Mechanisms of pulsus alternans.

Mechanisms of pulsus alternans.


Ultrastructural localization of Mg++-dependent dinitrophenol-stimulated adenosine triphosphatase in human blood platelets.


Positive long-acting thyroid stimulator response in the complement-deficient mouse.


Motor end plate reactivity to divalent metal ions histochemical studies.


Correlation between the presence of sulfated polysaccharides and mineralization in a marine coccolithophorid protozoon: histochemical and autoradiographic studies.


Histochemical observations of the enzymatic hydrolysis of gelatin films.


The synchronization of oestrus in cattle with progestagen-impregnated intravaginal sponges.


Comparative studies on various antituberculosis chemotherapies--from the results of the Tuberculosis Research Committee (Ryoken).


Inter heavy-light chain disulphide bridge in immune globulins.


The immune globulin content of the serum of calves in England.


Salt solubility of reaginic antibodies.

Salt solubility of reaginic antibodies.


Hypothyroidism induced by a transplanted fibrosarcoma in the rat.


Effect of cortisone on plasma volume, total blood volume and serum protein.


Serum concentration of alpha-2-macroglobulin, haptoglobin and alpha-1-antitrypsin in diabetes mellitus.


Fracture healing and mast cells. I. The periosteal callus in rats.


Fracture healing and mast cells. II. Influence of 17-hydroxy-corticosterone.


The slide.

The slide.


Variations in isosexual pseudoprecocious puberty.


Characterization and properties of an inhibitor of factor 8 in the plasma of patients with hemophilia A following repeated transfusions.


Localization of lysozyme activity in a Paneth cell granule fraction.


The polymorphism of "prealbumins" and alpha-1-antitrypsin in human sera.


Absence of insulin-like or insulin-binding action of alpha-2-macroglobulin.


Urinary protein clearances in chronic renal diseases with and without uremia.


Quantitative immunoassay by disc electrophoresis.


Selenium in blood and human tissues.

Selenium in blood and human tissues.


Inhibition of plasmin activity by alpha-2-macroglobulin.


Rhinovirus neutralizing antibody in tears, parotid saliva, nasal secretions and serum.


The removal by phospholipase C of a layer of lanthanum-staining material external to the cell membrane in embryonic chick cells. Fixation of embryonic chick cells (heart, neural retina, and limb bud) in the presence of lanthanum ions shows the presence of an electron-opaque layer, about 50 A thick, external to the cell membrane. This layer, designated LSM (for lanthanum-staining material), is not removable by trypsin, pronase, EDTA, DNase, alpha-amylase, neuraminidase, or N-acetyl-L-cysteine. However, phospholipase C, in concentrations as low as 0.001 mg/ml, succeeds in stripping the LSM from the cell surface. Heating the enzyme preparation does not inhibit this activity, but removal of divalent cations does; both of these results are consistent with the known properties of phospholipase C. The LSM is present at the cell surface in the control tissues and on cells dissociated from the tissues by proteolytic enzymes and EDTA. These results are interpreted to mean that the LSM is probably an integral part of the cell and not an extraneous coat. How this phenomenon bears on the problem of cellular adhesion is discussed, as is the possible chemical composition of the LSM.


Presence of kappa and lambda light chain determinants in 3 S-gamma-1-globulins of pooled normal human plasma.


Severe head injuries. A six-year follow-up.


Prevention of corneal-graft failure with the immunosuppressive drug azathioprine.


A possible interrelation between glucose-6-phosphate dehydrogenase and dehydroepiandrosterone in obesity.


Champagne-cork injury to the eye.

Champagne-cork injury to the eye.


Evaluation of clinical methods for detecting proteinuria.


Spontaneous arteriosclerosis in the wild African elephant. Its relation to the disease in man.


Impaired platelet-connective-tissue reaction in man after aspirin ingestion.


Induction of hyperglycaemia as treatment for peptic ulcers.


A new positive-pressure respirator for newborns.


Emergency treatment of hypercalcaemia.

Emergency treatment of hypercalcaemia.


Ageing.

Ageing.


Syphilis past and present.

Syphilis past and present.


Paying for the N.H.S.

Paying for the N.H.S.


Hallucinogen and teratogen?

Hallucinogen and teratogen?


Tides and babies.

Tides and babies.


Needs of science.

Needs of science.


Limb prostheses.

Limb prostheses.


The case for geriatrics.

The case for geriatrics.


Thrombosis and oestrogens.

Thrombosis and oestrogens.


Purpura after warfarin.

Purpura after warfarin.


Studies on histamine release and degradation in rhesus and squirrel monkeys.


Removal of a salivary stone in the submaxillary (Wharton's) duct near the orifice--using the Cavitron.


Handling germinated pollen on millipore membrane during the Feulgen and autoradiographic procedures.


Plain water as a rinsing agent preferable to sulfurous acid after the Feulgen nucleal reaction.


Agar gel electrophoresis: an advantageous technique for the investigation of certain biological stains.


Vital staining with neutral red and trypan blue of 3H-thymidine-labeled cells prior to autoradiography.


On glycogen in the cochlear duct of foetuses and young of albino rats.


Synchronisation of oestrus in ewes.

Synchronisation of oestrus in ewes.


Globuli interossei as a manifestation of bone resorption.


Serum proteins in the hedgehog.

Serum proteins in the hedgehog.


Histamine release from rat mast cells induced by a mast cell degranulating fraction in bee venom.


Margination of chromatin in dog kidney cells infected with infectious canine hepatitis virus.


Swine polioencephalomyelitis virus in germfree pigs: viral isolation, immunoreaction, and serum electrophoresis.


Preservation and observation of anaplasmas with tails in capillary tubes.


Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra.


Exocellular enzymes in lens root and auxin catabolism.


Substrate specificity and post-mortem effects in mammalian pineal acetylserotonin methyltransferase activity.


Frequence potentiation and paired stimulation potentiation of cat papillary muscles in calcium and in strontium containing media.


The hypothalamo-hypophyseal antidiuretic system in physical exercises.


Release of a bradykinin-like substance of nervous stimulation of a frog stomach muscle preparation.


Generation of membrane potentials in lepidopteran muscle. I. Analysis of a mixed electrode system in the skeletal muscle fibres of Sphinx ligustri (L.).


Effects of temperature on the duration and velocity of myocardial contraction in normal and low calcium media.


Lactate and pyruvate in the brain of rats during changes in acid-base balance.


The role of the sciatic nerve in the sympathetic innervation of the hind limb vasculature in the dog.


Modification by acoustical stimulation of the visually induced discharge patterns of colliculus superior neurons in the cat.


Suppression by amphotericin B of the effect exerted by aldosterone on active sodium transport.


Na efflux in cardiac Purkinje fibres: Effect of extracellular K, temperature, NaN3 and ouabain.


Sound-proofed rooms for experimentation in sensory physiology.


Studies on the activation of phosphorylase phosphatase isolated from adrenal cortex.


Covalent aggregation of rabbit immunoglobulin G and liberation of free H and L chains in the absence of exogenous reducing agents.


A comparative study on the interaction of sodium tungstate and potassium phosphotungstate with haemoglobin.


Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system.


A histochemical study of the esterases in the bladder of the toad (Bufo Marinus).


Comparative thyroid activity in two species of Peromyscus.


An artefact in radioautography due to binding of free amino acids to tissues by fixatives. The binding of labeled free amino acids to liver and to purified protein by commonly used fixatives was investigated. Glutaraldehyde caused 25% of free leucine to be bound to serum albumin in solution, whereas formaldehyde bound only 0.5%. Liver slices were incubated for 2 min in the presence of labeled leucine and of puromycin, which permits absorption of leucine into the cell but inhibits incorporation into protein. Both counting and radioautographic techniques showed that glutaraldehyde bound 30 times, and osmic acid six times, as much free amino acid as did formaldehyde. By comparing liver slices incubated with and without puromycin for 2 min, it was calculated that in radioautographs prepared after fixation with glutaraldehyde, osmic acid, or formaldehyde 63, 25, and 4% respectively of the grains were due to binding of free amino acid. Formaldehyde, freshly prepared from paraformaldehyde, gives good preservation and is the recommended fixative for radioautography. When levels of free substrate in a tissue are high at the time fixative is added, the amount of binding of free substrate induced by the fixative should be included as a control in radioautographic experiments.


The morphologic structure of isolated bacterial lipopolysaccharide.


The use of bis-diazotized benzidine for preparing ferritin-conjugated antibodies for electron microscopy.


A histochemical study of Gaucher's disease and Niemann-Pick's disease.


A new technique for sampling bone marrow in monkeys.


Histochemically demonstrable lipids in human eccrine and apocrine sweat glands.


Infcormation transfer in molluscan embryos.


Bone marrow and lymphoid cell injection of the pig foetus resulting in transplantation tolerance or immunity, and immunoglobulin production.


Cytological demonstration of carboxyhaemoglobin in human erythrocytes.


Indole nature of enterochromaffin substance.


Nerve fibres in optic nerve of rat.

Nerve fibres in optic nerve of rat.


C-terminal half of immunoglobulin lambda-chains.


Human serum antibodies against rat colon mucosa.


A histological and histochemical study on the effects of adrenal cortical steroids in the fetal and neonatal rat thymus.


Inhibitory and lethal effects of DNA on transformable streptococci.


The presence of two types of carbohydrate-amino acid linkage in the same glycoprotein.


The fragmentation of human IgD during storage.


The sarcoplasmic reticulum and its association with the T system in an insect. The fine structure of the sarcoplasmic reticulum and the transverse tubular system of the femoral muscle of the cockroach, Leucophaea maderae, was studied after prefixation in glutaraldehyde, postfixation in osmium tetroxide, and embedding in Epon. The sarcoplasmic reticulum in this muscle reveals features not previously reported. The sarcoplasmic reticulum is abundant, consisting mainly of a fenestrated envelope which surrounds each myofibril at all levels in the sarcomere. This sarcoplasmic reticulum envelope is continuous transversally as well as longitudinally along the myofibrils. Dyadic junctions are formed by a single T system element which contacts the unfenestrated sarcoplasmic reticulum of adjacent myofibrils in an alternating manner at the ends of the A band. At the dyads, regularly spaced thickenings of the sarcoplasmic reticulum membranes bordering the dyadic spaces are noted. These thickenings, however, do not contact the T tubule membrane. Typical dyadic contacts also are seen between the cell surface membrane and sarcoplasmic reticulum. Z line-like material is seen in contact with the membranes of the cell surface and longitudinal branches of the T systems.


Mitotic division of neuroglia in the normal adult rat.


A study of newt mitotic chromosomes by negative staining. A method is described for bursting single, selected mitotic cells on a fluid surface. Cells from cultures of newt heart tissue were burst on dilute solutions containing potassium and sodium with and without added calcium and also on dilute calcium chloride solution. The material was negatively stained with uranyl acetate or sometimes with ammonium molybdate or sodium phosphotungstate. The bodies of chromatids spread on NaCl/KCl solutions showed many parallel fibers about 150 A in diameter. Loops with a complex nodular structure were observed projecting from the sides and ends of chromatids. In calcium-containing solutions there was evidence of fiber coagulation; the chromatid body was more compact and laterally projecting fibers tended to be pulled out straight. Especially in the absence of calcium the chromosomal fibers had a nodular form and appeared to be composed of irregularly folded fibrillar elements. The question as to whether chromosomal fibers, which range in diameter from about 50 to 300 A, consist of single, folded threads or of two or more adjacent subunits is discussed.


Observations on nuclear differentiation in Ascaris.


Chemotherapy of epidermal infection with Dermatophilus congolensis.


On the histochemistry of azo group-free thiazole dyes.


Transferrin variants in Greeks.

Transferrin variants in Greeks.


Cytological studies of the ductuli efferentes of the opossum.


The physiological role of the lymphoid system, 3. Leucophilic gamma-globulin and the phagocytic activity of the polymorphonuclear leucocyte.


Sodium nitroprusside test for the detection of isoniazid and acetylisoniazid in urine.


Intermittent chemotherapy.

Intermittent chemotherapy.


Continuous arterial infusion chemotherapy. Experience with 44 cases.


Electrophoretic patterns of proteins in the blastocoelic fluid of the rabbit following ovariectomy.


Incus autografts and homografts in rats.


Studies in human hypophyseal ablative procedures.


The antibody mechanism of ragweed allergy. Electrophoretic and chemical studies. IV. Two reaginic variants demonstrated by rivanol fractionation, the major variant without relationship to beta-2A globulin.


Studies on the elimination of the complement inhibiting activity of human gamma-globulin using degradation with plasmin or gel filtration.


The action of phytohemagglutinin in rabbits. I. The enhancement of the primary immune response to human serum albumin, bovine gamma globulin and sheep erythrocytes.


Immunochemical comparison of proteins in human gingival pocket fluid, serum and saliva.


Dualistic thiourea moiety taste response of methimazole.


Skin biopsy.

Skin biopsy.


Thymic aplasia with lymphopenia, plasma cells, and normal immunoglobulins. Relation to measles virus infection.


Estimation of thyroid function by timing the arterial sounds.


The effects of hypothyroidism upon the ear, nose and throat. A clinical and experimental study.


Myxovirus as a possible etiologic agent in subacute inclusion-body encephalitis.


Effect of aging on the nerve supply to human teeth.


Effect of different colored stains on laser microbeam impact sites on tooth enamel.


The relation of RNA and protein synthesis to the sedimentation of muscle ribosomes: effect of diabetes and insulin.