Estimation of mucosal mucin as an aid in the differentiation of Crohn's disease of the colon and chronic ulcerative colitis.


Abnormal fetal heart rates and rhythms prior to labor.


A procedure for rapid and sensitive staining of protein fractionated by polyacrylamide gel electrophoresis.


The absorptive activity of ameloblasts during the maturation of enamel.


Ultrastructure of the carotid body of the cat as revealed by various fixatives and the use of reserpine.


Carboxyhemoglobin levels due to traffic exhaust.


The effect of the gamma isomer of benzene hexachloride upon the microflora of submerged rice soils. II. Effect upon nitrogen mineralization and fixation, and selected bacteria.


The influence of methimazole on the catecholamine excretion of cold-stressed rats.


Initial response of human thyroid, adrenal cortex, and adrenal medulla to acute cold exposure.


Histamine-liberating activity of serum protein exposed to DEAE-cellulose.


Fragmentation of human IgG globulin with papain, trypsin and pepsin.


Non-iodine containing compounds and [127I]iodotyrosine-like substances studied by paper- and thin-layer chromatography.


Immunoglobulin G of restricted electrophoretic mobility in certain human sera.


"Bound" complement in the epidermis of patients with pemphigus vulgaris.


Salivary immunoglobulins: normal adult values and dissociation between serum and salivary levels.


Sequence of events during germination of putrefactive anaerobe 3679 spores. The sequence of changes during germination of putrefactive anaerobe 3679h spores was studied under aerobic conditions in a solution containing l-alanine and sodium pyrophosphate. Evidence that specific changes occurred in two distinct regions of the spore is given by data on several criteria that were used to measure germination. During the initial stage of germination, the absorbancy decreased, dipicolinic acid was released, the spores lost their resistance to heat and toxic chemicals, and the spore periphery (cortex) darkened gradually under phase-contrast microscopy. The final stage of germination was characterized by changes in the central spore region (core), notably phase darkening of the spore center and stainability with mercurochrome, and by a slight additional absorbancy decrease.


Antibiotic treatment of anthrax infection in mice. Quantitative measurements of mean time to death, percentage of survivors, and viable cell populations in the whole body were employed to determine the effects of penicillin, dihydrostreptomycin, chlortetracycline, oxytetracycline, chloramphenicol, and antiserum on the course of anthrax infection in mice. By all parameters tested, penicillin and dihydrostreptomycin were most effective in the treatment of the disease. Therapy initiated in the later stages of the disease was more effective than that initiated in the earlier stages. Quantitative studies indicated that it was more difficult to eliminate organisms from the kidney than from any other organ or tissue. These measurements for the evaluation of antibiotic therapy are suggested for the study of other bacterial diseases.


Thermosensitive replication of a kanamycin resistance factor. A strain of Proteus vulgaris isolated from the urinary tract of a patient with postoperative pyelonephritis and resistant to sulfonamide, streptomycin, tetracycline, and kanamycin (KM) was found to transfer only KM resistance by cell-to-cell conjugation. The genetic determinant controlling the transferable KM resistance was considered to be an R factor and was designated R (KM). Successive transfer of KM resistance was demonstrated also from Escherichia coli 20S0, which received the R (KM) factor, to other substrains of E. coli K-12 or Salmonella typhimurium LT-2. The transfer of the R (KM) factor was strongly affected by the temperature at which the mating culture was kept. The transfer frequency of R (KM) at 25 C was about 10(5) times higher than at 37 C. The R (KM) factor was spontaneously eliminated from the host bacterial cells when P. vulgaris was cultured at 42 C, but no elimination occurred at 25 C. This elimination of the R (KM) factor at elevated temperature was also observed when the R (KM) factor infected E. coli and S. typhimurium. On the other hand, a normal R factor could not be eliminated from the same E. coli host strain by cultivation at the higher temperature. We consider the thermosensitive transfer and the spontaneous elimination of the R (KM) factor at higher temperature to depend upon thermosensitive replication of the R (KM) factor.


Effects of adrenochrome semicarbazone on blood loss in the mouse.


Effects of steroidal antifertility agents after two to six years of continuous use.


Some features of the antibody response of sheep.


Purpura with hypergammaglobulinaemia.

Purpura with hypergammaglobulinaemia.


Cells in bovine milk: differential staining in suspension: collecting, counting and examining on millipore membrane.


Enhancing tetrazolium-based histochemical stains by exposure to light.


Orcein-hematoxylin in iodized ferric chloride as a stain for elastic fibers, with metanil yellow counterstaining.


Relationships among pH, osmolality, and concentration of fixative solutions.


Standby pacing in multiple arrhythmias.

Standby pacing in multiple arrhythmias.


The use of papain in clearing plant tissues for whole mounts.


Luxol fast blue MBS and phloxine; a stain for mitochondria.


A simple method for purification of labeled thyroxine and measurement of free thyroxine in serum.


Removal of epidermis with sodium bromide for cholinesterase staining of dermal nerves.


Attaching frozen sections to slides for efficient handling in lipid staining.


3. Electrophoretic differentiation of myeloma and macroglobulinemia M-proteins. Effects of D,L-penicillamine and ephacridine lactate on M-proteins.


Effect of thymectomy on the golden hamster (Mesocricetus auratus). IV. Comparative studies on two hamster strains.


Coronal cementogenesis in cattle.

Coronal cementogenesis in cattle.


Extracellular sudanophilic material in dental structures.


The surgical significance of chylous ascites.


Controlling EDTA treatment to produce permeable Escherichia coli with normal metabolic processes.


The effect of the gamma-isomer of benzene hexachloride upon the microflora of submerged rice soils. I. Effect upon algae.


Aggregation of immunoglobulin fragments in concentrated urine.


Micro gel electrophoresis.

Micro gel electrophoresis.


Rapid testing of gamma-G-globulins for papain sensitivity.


Studies on the heterogeneity and serum binding of human growth hormone.


On the interaction of long-acting thyroid stimulator with thyroid microsomes.


Ultrastructure of the prawn nerve sheaths. Role of fixative and osmotic pressure in vesiculation of thin cytoplasmic laminae. The sheaths from freshly teased nerve fibers of the prawn exhibit a positive radial birefringence, consistent with their EM appearance as highly organized laminated structures composed of numerous thin cytoplasmic sheets or laminae bordered by unit membranes and arranged concentrically around the axon. The closely apposed membranes in these sheaths are fragile and often break down into rows of vesicles during fixation. Desmosome-like attachment zones occur in many regions of the sheath. The membranes within these zones resist vesiculation and thereby provide a "control" region for relating the type of vesicles formed in the fragile portions of the sheaths to the specific fixation conditions. It is proposed that during fixation the production of artifactual vesicles is governed by an interplay of three factors: (a) direct chemical action of the fixative on the polar strata of adjacent unit membranes, (b) osmotic forces applied to membranes during fixation, and (c) the pre-existing natural relations between adjacent membranes. It is found that permanganate best preserves the continuity of the membranes but will still produce vesicles if the fixative exerts severe osmotic forces. These results support other reports (19) of the importance of comparing tissues fixed by complementary procedures so that systematic artifacts will not be described as characteristic of the natural state.


Familial goiter due to an organification defect in euthyroid siblings.


The experimental healing of soft tissues.


A functional and morphologic study of intracranial thyroid allografts in the dog.


Hyperthyroidism and demonstration of circulating long-acting thyroid stimulator following hypophysectomy for chromophobe adenoma.


The use of Mohs' chemosurgery technique in the treatment of skin cancers.


Studies with intravenous gamma globulin.


Inter-and intra-species variations within the Xh antigen.


The preparation of gamma-globulin for intravenous use in Paris.


Instability of immune serum globulin solutions. II. In vivo studies on solutions which have fragmented during storage and on those fragmented by digestion with plasmin.


Studies on the stability of human gamma globulin.


Observations on the fragmentation of venous and placental immune serum globulins.


The preparation of plasmin treated immune serum globulin for intravenous use.


Intravenous gamma globulin. I. Background.


Intravenous use of plasmin treated immunoglobulin G. I. Preliminary report on tolerance by immunologically deficient patients.


Designated discussion.

Designated discussion.


Turnover of standard-gammaglobulin, pH-4-gammaglobulin and pepsin desaggregated gammaglobulin and clinical implications.


Paper chromatography of the streptomycins and some related compounds.


On the cytomorphologic and cytochemic characteristics of the aseptic inflammation. Fluorescent microscopic characteristics of the cytoplasmatic ribonucleoproteides.


Histochemistry of mucopolysaccharides in brain tumors.


Responses of thymidine labeling of nuclei in gray matter and nerve following sciatic transection.


Microglia cells in diffuse and granulomatous encephalitis in the rabbit.


Insulin binding proteins in normal serum. Qualitative and quantitative studies in vivo in cats.


Insulin binding proteins in normal serum. The in vitro association of homologous 125-I labelled insulin and normal serum proteins.


The effect of thyroidectomy on the hypothalamus of the rat with special reference to the hypothalamic-hypophyseal neurosecretory system.


Preparation of concentrated anti Semliki Forest virus gamma-globulins.


The split-line phenomenon and the microscopic structure of bone.


Interaction of heparin with the plasma proteins in relation to its antithrombin activity.


Further observations on tuberculosis of the right middle lobe in simple pneumoconiosis.


I. Observations on the differential diagnosis of medulloblastoma and ependymoblastoma.


Refsum's disease.

Refsum's disease.


Serum proteins and serum enzymes in tuberous sclerosis.


Exfoliative cytology of the early lesions of experimental oral cancer in the hamster.


"Auto-immune" chronic hepatitis.

"Auto-immune" chronic hepatitis.


Dietary intake of pesticide chemicals. Calculated daily consumption of pesticides with foods are discussed and compared with currently accepted values. Residues of chlorinated organic pesticide chemicals were commonly found in all diet samples and all food classes within samples except beverages at a daily intake of 0.0014 mg per kilogram of body weight. Meat, fish, and poultry were the major source of pesticide residues and, when combined with dairy products, account for more than half of the intake of chlorinated organic pesticide chemicals. Fruits, garden fruits, and grain foods each accounted for about 10 percent of the intake of chlorinated pesticides. The DDT, its two analogs, dieldrin, lindane, and heptachlor epoxide account for 85 percent of the total intake of chlorinated pesticides. A single pesticide, DDT, accounts for one-third of the total. There was no statistically significant change in frequency or quantities of these compounds during this study. Frequency and quantities of the 14 additional chlorinated pesticides were too low to be meaningful.


Histochemistry of bone formation in normal and tetracycline-treated chick embryos. I. Lipids.


A histological survey of the hammock ligament.


Immunoglobulin structure: variation in amino acid sequence and length of human lambda light chains. Variation and conservation in the primary structure of human lambda light chains is revealed by complete amino acid sequence of three Bence Jones proteins. These proteins differ in amino acid sequence in from 38 to 48 positions; they are of unequal length in the amino-terminal half of the chain but have identical sequence in the last 105 amino acids.


Physical work capacity, Ecg reaction to work test and coronary angiogram in coronary artery disease.


Histochemical and electron microscopic studies of dog kidney cells in the early stages of infection with infectious canine hepatitis virus.


Replication of infectious laryngotracheitis virus in chicken kidney cell culture.


Morphologic features of Haemobartonella felis.


Effect of antibiotic therapy on experimental leptospirosis infection and development of acquired resistance in guinea pigs.


Primary carcinoma of the lung: treatment of 1284 cases.


Studies of monoclonal immunoglobulins (M-components) in various kindreds.


"Selective" pituitary insufficiency secondary to busulfan.


Potentiation of tolbutamide by dicumarol.


Studies on two patients with concomitant pernicious anemia and immunoglobulin deficiency.


Alpha-1-antitrypsin, an inhibitor for thrombin and plasmin.


The specificity of the anti-hyaluronidase developed in beekeepers serum against bee venom hyaluronidase.


On immunoelectrophoretic quantitation.

On immunoelectrophoretic quantitation.


Antibodies directed to singly and doubly charged forms of the p-azobenzenearsonate group.


Antisera to covalently linked proteins.

Antisera to covalently linked proteins.


Amino-terminal studies of some pathological human serum immunoglobulins.


Presence of a unique serum protein in sera obtained from patients with neoplastic diseases and in embryonic and neonatal sera.


Quantitative determination of serum immunoglobulins by single radial immunodiffusion on cellulose acetate.


Heterogeneity of the light chains of rabbit immunoglobulin G fractions and of a series of antibodies directed towards antigens of differing complexity.


Equine anti-hapten antibody. IV. The effect of polyalanylation on affinity.


Cellulose-fixed immunoglobulin subunits.


A time-lapse study of effects of anticellular antibody on membrane mobility and phagocytic activity of HeLa cells.


Thyroxine transport in thyrotoxicosis and hypothyroidism. (a) The thyroxine-binding proteins were investigated in 23 cases of untreated thyrotoxicosis and 16 cases of untreated hypothyroidism, employing reverse flow paper electrophoresis with the glycine acetate system at pH 8.6 in the Durrum type cell.(b) In active thyrotoxicosis, all sera exhibited diminished thyroxine-binding prealbumin (TBPA) capacities. however, 17 of the 23 sera also had diminished thryroxine-binding alpha globulin (TBG) capacities, as well as markedly elevated free thyroxine fractions. In contrast, six thyrotoxic sera had normal TBG capacities and normal or slightly elevated free thyroxine fractions.(c) In hypothyroidism, the TBPA capacities showed no consistent deviation from the normal range. 11 of the 16 sera had elevated TBG capacities as well as markedly diminished free thyroxine fractions. In contrast, five hypothyroid sera had normal TBG capacities and normal or nearly normal free thyroxine fractions.(d) In thyrotoxicosis and hypothyroidism, the inverse correlation between free thyroxine fraction and TBG was much closer than that with TBPA. When diagnostic categories were considered separately, only TBG bore a significant inverse relation to the free thyroxine fraction. It is therefore suggested that in thyroid diseases TBG may sometimes play a more important role than TBPA in determining the free thyroxine fraction.(e) The demonstrated variations in the binding proteins were considered sufficient to explain the abnormalities of the free thyroxine fractions in thyroid disease.


Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C' hemolysis by cold agglutinins. The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of beta-globulins, C'4 and C'3. The red cells of such patients are abnormally resistant to C' hemolysis by cold agglutinin. Normal red cells can be made equally resistant to C' hemolysis by incubation with cold agglutinin and normal serum at temperatures which allow transient reactions between the red cells and cold agglutinins. The development of resistance to C' hemolysis was related to increasing susceptibility to agglutination in anti-beta(1c)- and anti-beta(1e)-sera and by increasing uptake of (131)I activity from labeled anti-beta-globulin serum containing antibodies for both globulins. There was decrease in the adsorption of (131)I-labeled cold agglutinin during the development of resistance to C' hemolysis and reduced susceptibility to agglutination by cold agglutinins. Since cold agglutinins have been demonstrated to dissociate from the red cell, leaving fractions of C' globulin attached, it is postulated that repeated transient reactions produce the accumulation of incomplete C' complexes. Steric hindrance by the adsorbed C' complexes is probably responsible for the inhibition of the reaction with cold agglutinin. There is evidence that the adsorbed C' complexes also interfere with the hemolytic action of C' even when cold agglutinin has become reattached to the red cells. The accumulation of C' complexes by cold agglutinins appears to be the most important factor in the abnormal resistance to C' hemolysis exhibited by the patient's red cells. Other factors, such as the heterogeneity within a population of normal cells, appear to be of minor significance.


Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse.


Equipment for the lecture theatre.

Equipment for the lecture theatre.


A simplified method for preparing slides and lecture notes.


Apanel discussion on thyroid disease. The 1966 Erskine memorial lecture.


Conversion of H3-phytol to phytanic acid and its incorporation into plasma lipid fractions in heredopathia atactica polyneuritiformis.


Mechanism of action of phenolic disinfectants. VII. Factors affecting binding of phenol derivatives to Micrococcus lysodeikticus cells.


Histochemical studies of PAS positive reticular cells in mouse thymus, with special reference to their relation to mast cells and pancreatic B-cells.


Application of membrane filtration to antibiotic quality control sterility testing.


Mechanisms of antithyroidal activity of methimazole.


Synthesis of the gamma-G heavy chain in rabbit lymph node cells.


Physiological release of histamine-14-C in the pyramidal cat.


Alkali degradation of rabbit gamma-G-immunoglobulin.


Fluorescence polarization of human gamma-G-immunoglobulins.


Incorporation of radioactive amino acids into gamma-globulin in a cell-free system from rat spleen.


Fetus-specific serum proteins in several mammals and their relation to human alpha-fetoprotein.


Localization of the lateral geniculate nucleus monophasic waves associated with paradoxical sleep in the cat.


Effect of bilateral optic nerve section on visual system monophasic wave activity in the cat.


Photomyoclonic response of epileptic and non-epileptic subjects during wakefulness, sleep and arousal.


The relationship between the intensity of repetitive photic stimulation and the cerebral response.


EEG frequency analysis related to age in normal adults.


Sleep patterns in late middle age males: an EEG study.


An electronic method for determining time-locked changes in neuronal firing rate.


An averaging technique for detection of EEG-intracellular potential relationships.


Topographical and methodological approach in the analysis of visual evoked potentials and of the alpha rhythm.


Alpha theory and non-specific cortical activation.


Encephalopathies in liver disease.

Encephalopathies in liver disease.


The analysis of foci by simultaneous bipolar and unipolar recordings.


Mogadon therapy of infantile spasms.

Mogadon therapy of infantile spasms.


Electroencephalographic follow-up examination in haemolytic disease of the newborn.


Status with psychomotor attacks.

Status with psychomotor attacks.


EEG changes in mumps meningoencephalitis of the adult.


Incidental seizures ("Gelegenheitskrämpfe") in aged persons.


Chronic subdural haematomas in intracranial vascular malformations.


EEG investigation in stutterers.

EEG investigation in stutterers.


Post-traumatic focal EEG activity in correlation with the direction of the blow to the head.


Electroencephalographic investigations on the question of the initial state under neuroleptic therapy.


EEG and rheoencephalographic investigations in a variety of vegetative conditions with respiratory anoxia.


Rheography of function.

Rheography of function.


Recovery cycle of visual evoked potentials in man.


Unit discharges from the claustrum of the cat activated by peripheral stimulation.


Evoked potentials in subjects with intracranial space-occupying lesions.


The evolution of physiological sleep in states of epilepsia partialis continuans.


A case report of subcortical direct diffusion in epilepsy with a focus in the anterior frontal region detectable in the post-ictal phase.


Observations on two kinds of post-traumatic status epilepticus.


Experimental epilepsy of myoclonic type induced by introduction of cobalt powder into the lower brain stem.


Strychnine tetanus in spinal cats. An analysis of motor and electrical phenomena.


Electrophysiological studies in 5 cases of primary hemifacial spasm.


Clinical and EEG effects of sleep deprivation in epileptics.


Polygraphic studies on the effect of high intravenous doses of thiamine in man.


Tonic deviational seizures and simultaneous unilateral depression of cortical activity.


"Stiff-man" syndrome. Clinical aspects and electrophysiological studies of a case.


Patterns of thalamic transmission during the deepest stage of natural sleep in the cat.


Changes occurring during sleep in the EEG discharges provoked by repetitive photic stimulation.


Abnormal movements persisting during sleep (fasciculations, facial spasm, spinal automatic movements).


The evolution of some types of rhythmical myoclonus during sleep.


Spontaneous sleep as an activator of the EEG.


Electroencephalographic studies in breath-holding attacks of infancy.


Some different aspects of post-tetanic phenomena in myasthenia gravis.


Clinical and EEG study of a case of barbiturate coma.


Centrifugal control of the olfactory bulb as revealed by induced slow potential changes.


Diffuse electrocortical effects elicited in the cat by stimulation or functional inactivation of the medial portion (pars magnocellularis) of the medial geniculate body.


EEG and behavioral study in cats with chronic thalamic lesions with particular regard to the spindles and paroxysmal activity.


Relations between the limbic system and the reticular meso-diencephalic formation at unitary level.


Modifications of cortical responsiveness in humans induced by drugs acting on the central nervous system.


Some aspects of the clinico-electroencephalographic examination in a case of infantile subacute sporadic encephalitis.


Electrophysiological study of the facial reflexes in normal subjects.


Further observations on the phenomena which occur in the spinal cord during desynchronized sleep.


On the limbic origin of some electrical activity recorded from frontal leads in humans.


Electroencephalographic findings in brain stem tumours.


Clinical and neurophysiological observations on the effect of Valium in one case of Ramsay-Hunt's "dyssynergia cerebellaris myoclonica".


The limitations of EEG examination in the diagnosis and localization of meningiomas.


EEG in brain abscess.

EEG in brain abscess.


The diagnostic role of EEG in cerebrovascular accidents.


Effect of dietetic therapy on EEG in phenylketonuria.


Electromyography of the extraocular muscles in ophthalmoplegia.


The relationship between a dysrhythmic electroencephalogram and the ulcer syndrome in children.


Observations in petit mal status.

Observations in petit mal status.


Centrencephalic epilepsy induced by electrical convulsive treatment.


Neurological and EEG follow-up in encephalitis due to West Nile fever.


The shoulder-hand syndrome in coronary disease.


The cytology and cytochemistry of acute leukaemias--a critical review.


Nitric acid leucofuchsin technique for myelinated nerves using cryostat sections.


A simple silver method for the demonstration of reticulin fibres.


Cheap labour-saving method of removing stain from methanol-acetic acid-water (50-20-50) used in differentiating amidoschwartz 10B used in protein staining.


Impaired renal acidification in patients with hypergammaglobulinemia.


The plasma cells of the cerebrospinal fluid.


Strucutral characteristics of human immunoglobulins.


The relative densities of monosynaptic pathways to the cell bodies and dendrites of the cat ventral horn.


Two types of lambda polypeptide chains in human immunoglobulins based on an amino acid substitution at position 190.


Characterization of a human macroglobulin. V. A Waldenström macroglobulin with antibody activity.


Polorography of CSF proteins.

Polorography of CSF proteins.


Electron microscopy of negatively-stained lipids.


The effects of negative stains on lipids and proteins observed in the electron microscope.


Gynecological findings in adolescence. A study of 514 patients.


A light and electron microscopic study of the pecten of the pigeon eye.


The fine structure of the zona glomerulosa and the zona fasciculata of the adrenal cortex of the opossum.


Changes in cells, matrix and water of calcifying turkey leg tendons.


The ultrastructure of myofibers in a reptilian heart: the boa constrictor.


Septal projections to nuclei functioning in oxytocin release.


The effect of pregnancy on the elastic membranes of mesometrial arteries in the guinea pig.


Control of periodontal problems in orthodontics by use of water irrigation.


Isopaque 440 (metrizoate); a new cardiovascular contrast medium. Experience with 100 consecutive cases.


Azide inhibition of mitochondrial electron transport. I. The aerobic steady state of succinate oxidation.


Editorial. A comment on teaching methods.


Diagnoses of psychotic patients with the Kahn test of symbol arrangement.


Azide inhibition of mitochondrial electron transport. II. Spectral changes induced by azide.


A comparison of agarose with agar in the immuno-electrophoretic demonstration of gamma-A-globulin.


Organo-chlorine pesticide residues in human depot fat.


Abdominal decompression in the treatment of the toxaemias of pregnancy.


Comparative incidence of goitre in pregnancy in Iceland and Scotland.


Maternal urinary oestrogen excretion as evidence of a foetal role in determining gestation at labour.


Some immunological studies of the nephrotic syndrome of Nigerian children.


Response to bypass ileostomy in ulcerative colitis and Crohn's disease of the colon.


Early symptoms of temporal arteritis.

Early symptoms of temporal arteritis.


Treatment of infertility and secondary amenorrhoea with follicle-stimulating hormone and chorionic gonadotrophin.


Loss of brain potassium in kwashiorkor.

Loss of brain potassium in kwashiorkor.


Hypolipidaemia in anaemia. Implications for the epidemiology of ischaemic heart-disease.


Measurement of effective renal plasma-flow by the clearance of 125-I-hippuran.


Treatment of chronic intrahepatic cholestasis with phenobarbitone.


Appraisal of the application of 99mTc in the assessment of gastric function.


A method of distinguishing death due to cardiac arrest from asphyxia.


Antilymphocyte serum.

Antilymphocyte serum.


Active immunisation against tetanus.

Active immunisation against tetanus.


Fallacies in medical education.

Fallacies in medical education.


Medical staffing in the National Health Service in England and Wales.


Hospital medical staffing in Scotland.

Hospital medical staffing in Scotland.


Repair mechanisms and variations in UV sensitivity within the cell cycle.


Antithyroid treatment: a personal series.


Serum alpha globulin fraction: survival-and-recovery effect in irradiated mice. An alpha macroglobulin fraction (19S) was isolated from the serum of rats and BC(3)F(1) mice by zonal ultracentrifugation. Both the isologous and heterologous macroglobulin fractions increased survival among BC(3)F(1) mice x-irradiated with 750 roentgens. The mouse macroglobulin fraction also enhanced radiation recovery of hematopoietic tissue as measured by colony-forming assay and iron-59 incorporation into erythropoietic cells. The overall difference in hematopoietic activity in the irradiated (400 roentgens) mice treated with the macroglobulin fraction, in comparison with this activity in the controls, was three- to fivefold in the bone marrow and nine- to tenfold in the spleen between days 4 and 7 after irradiation. This effect was not obtained with the isologous serum protein fraction containing proteins of smaller molecular weight.


Removal of background stain from paper electrophoresis strips by the use of electric current.


Transurethral electrocautery procedures in patients with cardiac pacemakers.


Presymptomatic Wilson's disease.

Presymptomatic Wilson's disease.


Herpes-simplex particles in acute necrotising encephalitis.


Herpes simplex encephalitis treated with idoxuridine and external decompression.


Incidence of antibodies against beta-lipoproteins (Ag system), and the factors influencing isoimmunisation in transfused patients in the U.S.A. and Italy.


Use of pentagastrin in a test of gastric acid secretion.


The antagonistic effect of carnitine in hyperthyroidism. Preliminary report.


Evaluation of carnitine--an antagonist of thyroid hormone. Clinical pharmacology report.


Glucose, free fatty acid, and insulin interrelations in kwashiorkor and marasmus.


Resolution of acute massive pulmonary embolism after pulmonary arterial infusion of streptokinase.


Comparison of colony-forming ability of normal and leukaemic human marrow in cell culture.


The tuberculin test.

The tuberculin test.


Chloroquine in the salt.

Chloroquine in the salt.


New laws on control of drugs?

New laws on control of drugs?


Nodules of the ear.

Nodules of the ear.


Postgraduate potpourri.

Postgraduate potpourri.


Cephaloridine in chronic bronchitis.

Cephaloridine in chronic bronchitis.


Plugging a persistent ductus.

Plugging a persistent ductus.


Cohort mortality from carcinoma of the cervix.


Acute necrotising encephalitis.

Acute necrotising encephalitis.


When is an anecdote?

When is an anecdote?


Hypersensitivity to tetracycline.

Hypersensitivity to tetracycline.


Side-effects of oral contraceptives.

Side-effects of oral contraceptives.


Psychotropic--hypnotic drug combination.


Automation of protein-bound iodine (PBI) determination.


Preliminary results of investigations on the use of the intradermal gamma-globulin test in viral hepatitis.


Simplified procedures for the BEI-determination.


Serum thyroxine determination.

Serum thyroxine determination.


Free thyroxine in serum.

Free thyroxine in serum.


"Free thyroxine index" in diagnosis of thyroid disease.


Determination of secretion rate for cortisol and aldosterone.


Estimation of protein concentration in urine and solutions of albumin and globulin.


The juxtaglomerular apparatus of the stenosed kidney in human hypertension.


Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor.


Absorption and control of specificity of antisera.


Corticosteroids in the treatment of viral hepatitis in children. A clinicopathological comparative study.


Allergy to seminal fluid.

Allergy to seminal fluid.


Gammaglobulin in prevention of rubella and congenital defect: a study of 30,000 pregnancies.


Incidence of rubella antibodies among pregnant women in six areas: prophylactic effect of two doses of gammaglobulin. Report to the Public Health Laboratory Service Rubella Working Party.


Paraproteins, benign or malignant?

Paraproteins, benign or malignant?


Metabolism of bovine immunoglobulin. II. Metabolism of bovine IgG in cattle with secondary hypoimmunoglobulinemia. The turnover of I(131)-labelled IgG has been studied in cattle with mild hypoimmunoglobulinemia secondary to gastrointestinal disorders. A gastrointestinal loss of immunoglobulin was the most likely cause of the hypoimmunoglobulinemic condition. Thus, 6 animals with severe digestive symptoms (diarrhoea) had increased turnover rates of I(131)-IgG, whereas animals that had recovered from diarrhoeal diseases had normal or even low turnover rates (table I). It is concluded that the pattern of immunoglobulin metabolism is closely related to the clinical picture of the digestive disease.


Renal and hepatic pathology following initial remission of acute leukemia induced by prednisone.


The appearance and staining properties of cell droplets and their relationship to lysosomes.


Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study.


Studies of Burkitt lymphoma cells. I. Establishment of a cell line (B35M) and its characteristics.


Balloon cell nevi.

Balloon cell nevi.


A new nasal decongestant in otolaryngology.


The effect of hair sprays, nasal sprays and deodorant sprays on the eyes.


DNA replication in salivary gland nuclei of Drosophila melanogaster at successive larval and prepupal stages.


The performance of positive crankcase ventilation systems on automobiles in Cincinnati, Ohio: report no. 2.


Computer analysis of the California cycle.


Determination of nitrogen oxides in auto exhaust.


Diazochrome transparencies for 35 mm slide projection.


Visual factors affecting transfer of training from a simulated to a real control situation.


Abolition of the permeability-enhancing properties of Hageman factor by specific antiserum.


A simple, direct, and sensitive technique for measurement of specific protein in dilute solution.


Relationship of lipoprotein lipase activity to triglyceride uptake in adipose tissue. Fasted rats injected with actinomycin or fed glucose show increased lipoprotein lipase activity of epididymal adipose tissue. Data from the actinomycin-treated animals showed a direct correlation between the lipoprotein lipase activity and the uptake of lipoprotein triglyceride by the epididymal fat pad in vitro and in vivo. Data from the animals fed glucose confirmed these findings in vitro. These data strongly suggest that lipoprotein lipase plays a major role in triglyceride deposition in adipose tissue.


Lupoid hepatitis.

Lupoid hepatitis.


Laparotomy for jaundice.

Laparotomy for jaundice.


Growth hormone in African pygmies.

Growth hormone in African pygmies.


Treatment of sarcoidosis. Report of a controlled therapeutic trial.


Fructose-induced hyperuricaemia.

Fructose-induced hyperuricaemia.


Diurnal variations of fibrinolytic activity and plasma-11-hydroxycorticosteroid levels.


Subclavian-steal syndrome and motor accidents.


The effect of vagotomy on gastric secretion elicited by pentagastrin in man. A multicentre study.


24-hour and 72-hour preservation of canine kidneys.


Effect of variation of the interval between venepuncture and measurement of platelet adhesiveness by the Payling Wright method.


A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma.


Nature of the gastric secretagogue in Zollinger-Ellison tumours.


Chlorpropamide treatment in diabetes insipidus.


Identity of the haemopoietic stem cell.

Identity of the haemopoietic stem cell.


The future of obstetrics and gynaecology.


Growth-hormone deficiency.

Growth-hormone deficiency.


The clinical application of Bayes' theorem.


Adverse reactions to psychotropic drugs.


Thromboembolism and oestrogen therapy.

Thromboembolism and oestrogen therapy.


Perthes-like changes in thalidomide children.


The cloistered thyroidologist.

The cloistered thyroidologist.


Mineral changes after norethynodrel.

Mineral changes after norethynodrel.


Comparison of high and low dosage levels of 131-I in the treatment of thyrotoxicosis.


A heparinoid-hyaluronidase ointment in the treatment of chronic leg ulcers.


Multi-ingredient cold remedies.

Multi-ingredient cold remedies.


Absorption of intact protein molecules across the pulmonary air-tissue barrier. The majority of heterologous serum albumin and globulin molecules introduced into the pulmonary alveoli of dogs are absorbed into the circulatory system antigenically intact. This function of the alveoli has both physiologic and pathologic importance.


Comparison of methods of detection for free estrogens and estrogen acetates on thin-layer chromatograms.


Freud, Signorelli, and Lacan: the repression of the signifier.


Lupus-like syndrome induced by procainamide.


Renal tubular acidosis. Three cases with immunoglobulin abnormalities in the patients and their kindreds.


Extrinsic laryngeal carcinoma. A clinical evaluation of 124 cases.


Carotid transposition for cancer chemotherapy.


Erythema elevatum diutinum. Presentation of a case and evaluation of laboratory and immunological status.


Cutaneous sarcoidosis and tuberculoid leprosy. A comparative histopathologic and histochemical study.


Reactive perforating collagenosis.

Reactive perforating collagenosis.


Cytoplasmic basic proteins of the frog oocyte. Cytochemical detection and electrophoretic characterization.


The effect of synovectomy on articular cartilage.


Follow-up notes on articles previously published in the journal. Elastosis in chronic acidosis: extensive calcification in tendons and soft tissues.


Cholinesterase enzymes in human primary teeth.


Estimation of the absolute thyroid uptake of stable 127-I using a simplified method and comparison of the results with two classic methods.


Adolescents brush better with an electric toothbrush.


The influence of premature primary molar extraction on bicuspid eruption.


Analogue computer studies of the growth characteristics of Escherichia coli following dihydrostreptomycin treatment.


Physico-chemical & antigenic characterization of human seminal plasma proteins: gamma globulins of human seminal plasma.


Wilms' tumor.

Wilms' tumor.


Sequential administration of hormones for control of conception.


Distinguishing skin scale particles.

Distinguishing skin scale particles.


Effect of ambulation in experimental tuberculosis.


Nasal decongestants.

Nasal decongestants.


Modern trends in the therapy of venous affections of the lower limbs.


Passive immunization with gamma globulin.


[Clinical and experimental studies on serum protein-bound iodine in children. 1. Serum protein-bound iodine values in normal children].


Dyes as research tools in biology and medicine.


Radiofrequency cordotomy for intractable pain.


Hemocholecyst. Report of a case associated with anticoagulation therapy.


Simplified method of staining cytology smears by the Papanicolaou method.


Cytochemical studies on leukemic cells. I. Stable Nadi oxidase, peroxidase, DOPA oxidase and Sudan black B reaction.


Cytochemical studies on leukemic cells. II. PAS, succinic dehydrogenase, alkaline and acid phosphatase and nonspecific esterase reaction.


Rubella immunity of pregnant women in Stockholm.


Effect of prolonged cyclic therapy with estrogen-progestin combinations on thyroid function.


A case of thymic alymphoplasia with synthesis of IgM globulin.


Retrocorneal pigmentation with special reference to the formation of retrocorneal membranes by uveal melanocytes.


Effect of dihydrostreptomycin on adenosine triphosphatase activity.


Marginalia: introduction to immunoglobulins.


Symbols: content and process.

Symbols: content and process.


L.E. cell phenomenon.

L.E. cell phenomenon.


Carcinoma of tongue.

Carcinoma of tongue.


Histochemical study of the mucosubstances in the canine stomach. I. The resting mucosa.


Levels of serum immunoglobulins in patients with rheumatoid arthritis.


Training behavior therapists.

Training behavior therapists.


Natural history of Refsum's syndrome in a Gloucestershire family.


Fragmentation of immunoglobulin G in immune serum globulin. Prepared by the Committee on Plasma and Plasma Substitutes of the Division of Medical Sciences, National Research Council.


Successful treatment of epizootic cough in the horse.


Viruses and renal carcinoma of Rana pipiens. 3. The relationship between input multiplicity of infection and inclusion body formation in frog virus 3-infected cells.


Some factors affecting ouabain-induced ventricular arrhythmia in the reserpine-treated cat.


Substitution reactions of the 2-aminophenoxaz-3-one system.


The ultimobranchial body of the chick embryo.


Cytoplasmic changes in the crypt cells of the mouse small intestine.


Mechanism of thrombocytopenia in idiopathic thrombocytopenic purpura (ITP). IV. Evaluation of fluorescent antibody method and specific staining of platelets and megakaryocytes of ITP.


Comparison of comprehension of two forms of compressed speech.


Benign enlargement of the prostate.

Benign enlargement of the prostate.


An effective hypnotic in malignant disease.


Studies in vitro of the passage of serum proteins across the intestinal wall of young rats.


Immunogenetic studies on mongolism.

Immunogenetic studies on mongolism.


Studies on spatial vector analysis of the electrocardiogram in hyperthyroidism.


Possible solutions to some educational problems in veterinary medicine.


Surgical management of primary hyperthyroidism.


Serum proteins in children with recurrent pustular eruptions.


The exposure to carbon monoxide of occupants of vehicle moving in heavy traffic.


Evaluation of a new topical nasal decongestant.


The chemical structure of the heavy chains of rabbit and human immunoglobulin G (IgG).


Studies on the amino acid sequence of heavy chains from rabbit immunoglobulin G.


The Mackler tube instead of feeding gastrostomy for inoperable cancer of the esophagus.


DMSO and other combatants against bacteria isolated from leukemia and cancer patients.


Clinical evaluation of dimethyl sulfoxide in equine applications.


Disturbances of visuo-motor integration in cats with small lesions of the caudate nucleus.


Glycopeptides of immunoglobulins. Investigations on IgA myeloma globulins. The oligosaccharide units of a type K and a type L IgA immunoglobulin have been examined. The two proteins differed in their content of 6-deoxy-l-galactose and N-acetylneuraminic acid, and in the d-mannose/d-galactose ratio. With glycopeptides prepared from the type K protein, specific glycosidases liberated the N-acetylneuraminic acid and 7-8 residues of 2-acetamido-2-deoxy-d-glucose, and mild acid hydrolysis released most of the 6-deoxy-l-galactose. The type K immunoglobulin appeared to contain 3 oligosaccharide units, whereas the type L protein probably contained 3 or more units.


Radiotherapy in the management of carcinoma of the lung.


Methods of demonstration of lipid deposits in angiokeratoma corporis diffusum. (Diagnostic significance of skin biopsies).


Immunoglobulins and interferon responses in infectious and transfusion associated hepatitis.


A comparison of light microscopy staining methods applied to a polyester and three epoxy resins.


Thiacetazone toxicity--a case note.

Thiacetazone toxicity--a case note.


The origin, development and differentiation of Brunner's glands in the rat.


An anatomy of words used in a word-matching phonetic symbolism experiment.


Toxic reaction with 'isozone'.

Toxic reaction with 'isozone'.


The adamantyl group in medicinal agents. 3. Nucleoside 5'-adamantoates. The adamantoyl function as a protecting group.


A study on binding of PAS with serum albumin by BCG metachromasy.


Sorting and arranging KTSA objects according to emotional category and preference under simulated "psychosis".


Standardization and construct validity of the physiognomic cue test.


Relationship of the anticomplement Coombs test to the classes of immunoglobulins.


Scrapie in the rat: an electron-microscope study. I. Amyloid bodies and deposits.


Effect of metallic cations on human serum: study by starch-gel electrophoresis. II. Effect of Hg++, Cr+++, Ag+, Ni++, Cd++, Zn++, Ba++, Mg++, Al+++, and Fe+++.


Lupoid hepatitis: computer analysis defining "hepatitis" and "cirrhosis" phases and relationships between hepatocellular damage and immune reactions in the liver.


The role of circulating fluid volume and related physiological parameters in the control of aldosterone secretion.


The reproducibility and accuracy of plasma volume estimation in the sheep with both 131I gamma globulin and Evan's blue.


Return of gamma-aminobutyrate transaminase activity in mouse brain after inhibition by aminooxyacetic acid: chemical and histochemical observations.


The psyche-soma comples: an exercise in symbolic logic.


Diagnostic value of the Rivanol test in the evaluation of Dysproteinemia in rheumatoid arthritis in children.


Disbalance of immunoglobulins. The clinical importance of increased serum levels of immunoglobin-A and -G in combination with normal or diminished immunoglobulin-M concentrations.


Evaluation of renal filter selectivity by quantitative immunoelectrophoresis.


The pathogenesis of hydrocephalus in newborn rats deficient in vitamin B12.


Enzymatic digestion in the cytochemical demonstration of glycogen.


The reproducibility of tests of thyroid function.


Lack of proteolytic digestion in the causation of pernicious anaemia.


Successful exclusion of a massive, intra-abdominal haemophilic pseudo-tumour, with primary wound healing.


Diagnosis of babesiasis by fluorescence microscopy.


The electrophoretic pattern of serum proteins in normal animals.


Immunological studies in the cat. I. The serological response to some foreign proteins.


Perforated BEEM capsules for precipitate-free transfer of ultrathin sections through staining solutions.


Cyanuric chloride and n-methyl morpholine in methanol as a fixative for polysaccharides.


A staining sequence for A, B and D cells of pancreatic islets.


Tests for nucleic acid selectivity of Einarson's gallocyanin-chrome alum stain on monolayers of strain L-929 mouse fibroblasts.


A safranin-fast green stain for the differentiation of the nuclei of rumen protozoa.


Staining pollen tubes in the style; cotton blue versus carmine for general use.


On-the-slide impregnation by albumen-OsO4, selective for ciliary basal bodies and osmiophilic granules in synaptic terminals.


Improved preparation of polyvinyl alcohol-HgC12 fixative used for fecal smears.


Equipment for simultaneous processing of groups of slides for radioautography.


Viable and nonviable human cartilage homografts.


Effects of actinomycin and puromycin on the cytochemical-staining characteristics of vaccinia-infected cells.


Studies on blood vascular silver-blackened fibers (SF, BSF) related to heart beat and blood vascular phenomenon in vertebrates. VI. Observation on behaviors of silver-blackened fibers (SF) of the heart to drugs. Light and electron microscopic observations on morphological changes in myopolycin.


Studies on blood vascular silver-blackened fibers (SF, BSF) related to heart beat and vascular phenomenon in vertebrates. V. Biochemical observations on silver-blackable fibers (SF) related to the autonomicity of the heart: isolation of crystals and analysis of silver-blackable fibers.


Ataxia telangiectasia.

Ataxia telangiectasia.


Degrees and variations in immunoglobulin responses in infectious hepatitis.


Reappraisal of Whipple's disease.

Reappraisal of Whipple's disease.


Early premature ventricular beats, repetitive ventricular response, and ventricular fibrillation.


Argot, symbolic deviance and subcultural delinquency.


A morphologic and histochemical study of three oxidative enzymes in the hamster submandibular gland.


Lupoid hepatitis with oesophageal varices.


The fibre systems of sputum: significance and simple techniques of demonstration.


Treatment of thyrotoxicosis based on thyroidal suppressiblity.


A follow-up of thyrotoxic patients treated by partial thyroidectomy.


Chronic mucocutaneous candidiasis, deficiency of delayed hypersensitivity, and selective local antibody defect.


Medical and surgical treatment of Q-fever endocarditis.


Threshold adrenocortical sensitivity in man and its possible application to corticotrophin bioassay.


Effect of deafferentation on human physiological tremor.


Antibody and tuberculous lesions.

Antibody and tuberculous lesions.


The scrapie agent.

The scrapie agent.


Who's for screening?

Who's for screening?


A dangerous status symbol.

A dangerous status symbol.


Radioimmunoassay of angiotensin.

Radioimmunoassay of angiotensin.


Fatty acids and multiple sclerosis.

Fatty acids and multiple sclerosis.


Economics of road safety.

Economics of road safety.


Amantadine.

Amantadine.


William Budd.

William Budd.


The "at risk" infant.

The "at risk" infant.


An experiment in university teaching. I.


The responsibility of the anesthesiologist to the chronically ill patient.


Intranasal medication.

Intranasal medication.


Gamma-M synthesis during the secondary antibody response in mice.


High specific activity labeling of protein with I-131 by the iodine monochloride method.


Neutralization of alpha-staphylotoxin cytotoxic effect with human and monkey immune globulins.


Influence of diet and heredity on the serum protein components of the rat.


Gm and Inv antigenic character of serum and cerebrospinal fluid IgG in multiple sclerosis.


Optimal labeling of antibody with fluorescein isothiocyanate.


Immunity in staphylococcal infection: effect of gamma globulin on burn infections.


Actinomycin D: inhibition of estrogen-induced enzyme synthesis in uteri of adrenalectomized rats.


The results of adrenalectomy in advanced breast cancer in 500 consecutive patients.


A topical nasal decongestant for children.


Synthesis of azaindenes. The benzo[c]pyrazolo[1,2-a]cinnolinium cation, a novel heteroaromatic cation.


Senile dementia.

Senile dementia.


Antibody heterogeneity and serological reactions.


Modified hematoxylin and eosin staining technique for frozen sections.


I-131-triiodothyronine resin uptake, serum protein-bound iodine and serum cholesterol tests in normal dogs.


Metabolic balance studies with norethynodrel and chlormadinone acetate. The metabolic effects of daily administration of 5 mg norethynodrel or 2 mg.  chlormadinone acetate were studied on 6 women maintained on 80 mcg mestranol.  Metabolic studies were made for 7 days on mestranol alone and for 3 weeks after the progestagen was given.  In each case in which it was measured, body weight remained fairly constant but lean and fat body mass shifted toward a decrease in fat or a loss in body water or a real increase in high density components.  There was a positive nitrogen balance and a more negative phosphorus balance when subject received the progestogen.  When progestagen and estrogen were used there was more marked sodium retention than with estrogen alone.


The natural history of the autonomous hyperfunctioning thyroid nodule.


A healthy tooth and its supporting tissues.


Growth of rubella virus in BHK21 cells. II. Enhancing effect of DEAE-dextran, semicarbazide and low doses of metabolic inhibitors.


On the mechanism of the inhibition of compensatory ovarian hypertrophy by goitrogens.


Prolactin as a goitrogenic agent in amphibia.


Some factors affecting the interferon-induced antiviral state.


Reovirus type 2-infection, cycloheximide, and cell death.


Further observations concerning the effect of actinomycin D on thyroidal iodide transport in rats.


Response of the thymus and immunologically induced lymphopenia.


The effect of scientific and technological advance on medicine; its implications for medical education.


The influence of improved mixture quality on engine exhaust emissions and performance.


Estimation of smog effects in the hydrocarbon-nitric oxide system.


A method for standardizing the photographic reproduction of charts and graphs.


Intramural production of non-technical films.


A storage and retrieval system for projection slides.


Quantity dipping and processing of radioautographic slides.


Conglobate acne vulgaris associated with low levels of serum gamma globulin.


Acid mucopolysaccharide and mast cell variations in endometrium and some uterine tumors.


Clinical staging of carcinoma of the uterine tube.


Hypersensitivity due to antigen-antibody interaction.


The buccal mucosa cell count in health, protein-calorie deficiency, infection and old age.


Prevention of rhesus haemolytic disease. A preliminary report.


The fine structure of the lymphatics and the passage of China ink particles through their walls. 1. The fine structure of the lymphatics of the cattle lung and the passage of China ink through their walls.


The fine structure of the lymphatics and the passage of China ink particles through their walls. 2. Electron microscopic findings of the fine structure of the internal thoracic lymphatics of living rabbits and sites of escape of carbon particles from the vessels.


The therapeutic challenge of the advanced cancer patient.


Sex chromatin screening with millipore technic.


Influence of infection with parainfluenza 3 virus on the staining of KB cells with acridine orange.


Preliminary report on the effects of L-triiodothyronine, radioactive iodine-131, and methimazole on experimental murine leprosy.


Museum preparations of the segments of the human lung.


Quantitative occurrence of bacteria in hyperplastic prostatic tissue and its correlation to bacteriuria.


3-S-gamma-1-globulin levels of normal human serum and urine.


Comparative histochemical localization of lysosomal enzymes in rat tissues.


Fluorochrome staining of mycobacteria.

Fluorochrome staining of mycobacteria.


An evaluation of cryostat technique in a routine surgical laboratory.


Comparative evaluation of palliation with fluorometholone (NSC-33001), 5-fluorouracil (NSC-19893), and combined fluorometholone and 5-fluorouracil in advanced gastrointestinal cancer.


The use of oral decongestants in the management of diverse types of nasal congestion.


Palliative operations in congenital heart disease. Current status.


Comparative studies with isoniazid alone, isoniazid with thiacetazone and isoniazid with para-aminosalicylic acid in ambulatory treatment of pulmonary tuberculosis.


The immunoglobulins: nomenclature, structural aspects and changes in disease.


Immune globulins and the gastrointestinal tract.


A rapid hematoxylin and eosin stain.

A rapid hematoxylin and eosin stain.


A new fixative for the cytochemical examination of blood and bone marrow smears.


The stained urinary sediment examination.


Some molecular controls in biology.

Some molecular controls in biology.


The mechansim of bacterial sexuality.

The mechansim of bacterial sexuality.


The tension state: treatment with audio-visual aid.


A staining method for smears of peripheral blood.


1,2-dibromopyracylene: a new aromatic system.


Phenazocine hydrobromide BPC in the management of incurable malignant disease.


The use of gamma-globulin in the prophylaxis of transfusion hepatitis.


Gamma globulin in outbreaks of infectious hepatitis.


Physiology and ultrastructure of electrotonic junctions. I. Supramedullary neurons.


Physiology and ultrastructure of electrotonic junctions. II. Spinal and medullary electromotor nuclei in mormyrid fish.


Role of brainstem auditory structures in sound localization. I. Trapezoid body, superior olive, and lateral lemniscus.


Histology of infection by Pseudomonas lachrymans.


A guide for producing 35 mm. black and white slides from radiographs.


Postoperative anticoagulant prophylaxis of venous thrombosis with dicoumarol.


Diuretics as an adjunct in the treatment of acute venous thrombosis.


Marked aortic hemosiderin deposits in a patient with hemochromatosis.


Oncocytic papillary cystadenoma of the larynx. Presentation of two cases.


Therapeutic aids.

Therapeutic aids.


A place to explore.

A place to explore.


An approach to abnormalities in gamma globulin.


The nature of lipid globules in Hensen's cells.


Ultrastructure of the organ of Corti following intermixing of cochlear fluids.


Acid phosphatase-positive cytoplasmic bodies in leukocytes of rheumatoid synovial fluid.


The management of suspected recurrent intra-abdominal cancer.


Evidence for the existence of an IgM immuno-globulin to insulin.


The limiting thickness of protein films.


Meaning, value, and the theory of promotion.


The immunoglobulins.

The immunoglobulins.


Organometallic compounds in nucleic acid chemistry. LA-3610-MS.


The seminiferous tubule in mammals.

The seminiferous tubule in mammals.


Cell movement and cell contact in sea urchin morphogenesis.


Heavy metals in biological systems.

Heavy metals in biological systems.


Producing mental health teaching materials.


Cardiac arrhythmias in premature infants: an indication of autonomic immaturity?


Small-intestinal structure and function and haematological changes in dermatitis herpetiformis.


Incidence and management of supraventricular arrhythmias after acute myocardial infarction.


Relation between bradycardia and the site of myocardial infarction.


Chronic dehydration and sodium depletion in patients with established ileostomies.


Serum-creatine-kinase in cases of stroke, head injury, and meningitis.


Differences in acid-base levels and oxygen-saturation between central venous and arterial blood.


Tuberculin sensitivity in Crohn's disease. A controlled study.


Circulatory effects of nicotine aerosol inhalations and cigarette smoking in man.


After Sainsbury.

After Sainsbury.


Significance of erythrocytosis and increased erythropoietin secretion after renal transplantation.


Investigation of pancreatic function.

Investigation of pancreatic function.


Equipment of ambulances.

Equipment of ambulances.


Tick-borne encephalitis.

Tick-borne encephalitis.


Capital investment in the hospital service.


Management of renal hypertension complicated by renal insufficiency.


Mental illness in doctors.

Mental illness in doctors.


Behavior: a new synthesis?

Behavior: a new synthesis?


A no-smoking ward.

A no-smoking ward.


Pharmaceutical industry and the N.H.S.

Pharmaceutical industry and the N.H.S.


Bridewell revisited.

Bridewell revisited.


James Rögnvald Learmonth.

James Rögnvald Learmonth.


Leonard Colebrook.

Leonard Colebrook.


Origin of bacteria in bileduct bile.

Origin of bacteria in bileduct bile.


Pregnancy and scoliosis.

Pregnancy and scoliosis.


Plasma free aminoacid pattern in protein-calorie malnutrition. Reappraisal of its diagnostic value.


Changes in blood-volume produced by treatment in the nephrotic syndrome.


Coronary-artery disease in hypothyroidism. Observations in clinical myxoedema.


Total-dose iron-dextran infusions in general surgery.


The distribution of electrolytes and water in patients after taking lithium carbonate.


Intensive intravenous potassium replacement therapy.


When is consent?

When is consent?


Management of burns.

Management of burns.


Chymopapain and the intervertebral disc.


Calcium in arteries.

Calcium in arteries.


The E.S.R.

The E.S.R.


Wages of addiction.

Wages of addiction.


Now for the difficult ones.

Now for the difficult ones.


Antibiotics in renal failure.

Antibiotics in renal failure.


Early evaluation of psychotropic drugs in man. A trial that failed.


Work load and the general practitioner.

Work load and the general practitioner.


Proteinuria and nephrotic syndrome associated with chronic rejection of kidney transplants.


Control of diarrhea in secondary hypogammaglobulinemia by fresh plasma infusions.


Symposium on hyperthyroidism. Laboratory tests in diagnosis.


Spontaneous reactivation of experimental herpes simplex keratitis in rabbits.


Carcinoma of the prostate in sex chromatin positive (XXX/XY) Klinefelter's syndrome.


Mucogenic adenocarcinoma of the prostate.


Cancer cryotherapy.

Cancer cryotherapy.


Combination therapy in hay fever and allergic rhinitis.


On the genetics of the human allotypes, Gm and Inv.


The cellular pattern in invasive oncospheres of Hymenolepis diminuta as revealed by an enzyme-acetic acid-orcein method.


Chronic familial granulomatosis. Report of five cases and review of the literature.


The prognostic value of the serum proteins in ulcerative colitis.


Chemotherapy of inoperable malignancy.

Chemotherapy of inoperable malignancy.


Progressive hypergammaglobulinaemic hepatitis.


The survival of renal allografts in dogs treated with immunosuppressive drugs.


Dangers of immunization in immunologically incompetent individuals.


The differentiation and maturation of specific immune mechanisms.


Ligand-binding sites for streptolysin O and staphylococcal protein A on different parts of the same myeloma globulin.


DMSO an adjutant to physical therapy in the chronic frozen shoulder.


Polypeptide chain structure of rabbit immunoglobulins. 3. Secretory gamma-A-immunoglobulin from colostrum.


Positive staining of protein molecules for electron microscopy.


Extracellular potential field of antidromically activated CA1 pyramidal neurons.


IgM and IgG antibodies after immunization with organ-specific testicular antigen.


Comparison of the haemoglobin and gamma globulin molecule from the aspect of structure and the genetic control of synthesis.


The droplets of immature rat kidney.

The droplets of immature rat kidney.


Comparative study of teaching methods in human gross anatomy.


Orientation of collagen fibres in rat dentine.


Morphology of prostatic cancer and its relationship to nodular hyperplasia.


Effects of continuous feeding of hygromycin B on performance, fertility and hatchability of a commercial laying stock.


The nature of polysomes isolated from spleen cells of rats stimulated by antigen.


The role of audio-visual materials in more effective instruction for nurses.


The difference is you.

The difference is you.


Anti-antibodies.

Anti-antibodies.


Tolerance.

Tolerance.


Prevention of Rhesus haemolytic disease.


Prevention of Rh-haemolytic disease.

Prevention of Rh-haemolytic disease.


Zinc and magnesium in human prostate gland: normal, hyperplastic, and neoplastic.


Biology of the prostate gland: the electron microscopy of cytoplasmic filamentious bodies in human benign prostatic cells adjacent to cancerous cells.


Separation of a histamine-binding fraction from normal human serum.


Prisms in strabismus.

Prisms in strabismus.


The chemistry of the immunoglobulins.

The chemistry of the immunoglobulins.


Common tests of thyroid function in serum.


Fat mobilizing substance (FMS).

Fat mobilizing substance (FMS).


Brain abscess due to Actinobacillus actinomycetemcomitans.


Toxoplasma antibody levels in persons associated with sheep.


Gamma globulins: structure and control of biosynthesis.


Cystourethrography as a teaching aid for residents.


The zeta potentials of some selected solids in respect to plasma and plasma fractions.


Ocular vaccinia.

Ocular vaccinia.


Methylene blue (methylthionine) vital staining of the cornea and conjunctiva.


Trypan blue. Vital staining of cornea and conjunctiva.


Use of water-soluble polymers for the isolation and purification of human immunoglobulins.


Influence of guanidine on the production and antiviral action of interferon and on the synthesis of cellular proteins.


FDNB staining of proteins separated by disc electrophoresis.


Separation and quantitation of lactic dehydrogenase isoenzymes by disc electrophoresis.


Gas-liquid chromatography of derivatives of several amino acids that occur in the actinomycins.


Electrophoretic separation of soluble rat liver cell proteins on gelatinized cellulose acetate.


Studies on the elastase-serum protein interaction. I. Molecular identity of the inhibitors in human serum and direct demonstration of inhibitor-elastase complexes by zone and immunoelectrophoresis.


Ability of normal and tumor tissues to take up heterologous proteins.


The cytotoxic and cytostatic effect of actinomycins C and K on glia-like tumors growing in vitro.


The relation between structure and function in electron transport systems. II. Effect of solvent treatment on membrane structure.


Phospholipid model membranes. I. Structural characteristics of hydrated liquid crystals.


Substituted 2-oxazolidinethiones.

Substituted 2-oxazolidinethiones.


3-halogenated thyronines.

3-halogenated thyronines.


Identification of Candida albicans, other Candida species and Torulopsis glabrata by means of immunofluorescence.


RNA synthesis in intact rat liver nuclei.


Stability of structures of human gamma-globulin.


The existence of an acid-active hyaluronidase in serum.


"A.T. 10" and dihydrotachysterol.

"A.T. 10" and dihydrotachysterol.


Studies on the nature of plasma thyroid stimulating activity in hyperthyroidism.


Generation and use of antibodies to angiotensin II.


Sequence of IgM and IgG antibody synthesis in mice.


Variations in the C-terminal half of immunoglobulin gamma-chains.


The amino acid sequence of the N-terminal 84 residues of a human heavy chain of immunoglobulin G (Daw).


Variation of sedimentation coefficient with rotor velocity. The sedimentation coefficients of three proteins, which appeared homogeneous in the ultracentrifuge, have been determined at different rotor velocities. Two of the proteins, ovalbumin and human gamma-globulin, showed sedimentation coefficients that were approx. 10% higher at rotor velocities below 20000rev./min. than at 56100rev./min. The third protein, haemocyanin of Jasus lalandii, could not be investigated over the same rotor-velocity range, but it showed a similar effect.


Cyanogen bromide cleavage and partial sequence of the heavy chain of a pathological immunoglobulin G. The heavy chain of a pathological immunoglobulin G (Daw) of type L, subclass gamma(2b) (We) and Gm(a+)(f-), has been cleaved with cyanogen bromide. The five fragments resulting from the cleavage have been isolated and analysed. The papain-digest fragments, Fab and Fc, have also been cleaved with cyanogen bromide and the products analysed and compared with those from the heavy chain. The order of the five fragments in the heavy chain has been established and the location of some of the inter-chain and inter-fragment disulphide bonds has been determined. The sequence of the N-terminal fragment consisting of 34 residues is reported.


Enzymic degradation of the Fc fragment of rabbit immunoglobulin IgG. The digestion of the Fc fragment of rabbit immunoglobulin IgG by several proteolytic enzymes was investigated by using gel filtration and starch-gel electrophoresis in 8m-urea-formate as criteria of the extent of degradation. Though fragment Fc and mildly reduced fragment Fc proved resistant to tryptic hydrolysis, papain and pepsin cleaved the fragment at acidic pH values and appeared to give rise to a similar spectrum of products. A (limit) peptide comprising the C-terminal 113 residues of the heavy chain was isolated and identified from the pepsin-digest products of fragment Fc. The products of proteolytic digestion of fragment Fc were no longer able to inhibit passive cutaneous anaphylaxis by rabbit anti-(bovine serum albumin) or demonstrate reversed passive cutaneous anaphylaxis in the guinea pig. Nor were they able to inhibit the intestinal absorption of heterologous immunoglobulin IgG in the young mouse. These studies imply that the site or sites responsible for these biological properties of intact fragment Fc reside in the N-terminal 30-40% of the fragment.


Studies on the rapidly labeled RNA of rabbit bone marrow cells.


Structure of normal and contracted tail sheaths of T4 bacteriophage.


The myosin filament. I. Structural organization from antibody staining observed in electron microscopy.


Hill reaction site in chloroplast membranes: non-participation of the quantasome particle in photoreduction.


Multiple sclerosis: brain immunoglobulin-G and albumin.


A "new" allotypic specificity (A9) of rabbit immunoglobulin.


Gastric secretion during pregnancy and lactation in the rat. 1. Gastric acid secretion has been studied in the rat before, during and after pregnancy using different types of stomach preparation. During the same periods the histamine-forming capacity (HFC) has been determined in gastric mucosa and mammary gland.2. In rats with a whole stomach fistula interdigestive acid secretion is increased during pregnancy and lactation.3. In rats with a denervated chronic pouch secretory response to stimulation with gastrin and histamine is augmented during pregnancy and lactation.4. The histamine forming capacity (HFC) of the gastric mucosa is increased 2-3 times during the last days of pregnancy and also during lactation.5. The HFC of the mammary gland is increased 2-3 times during lactation as compared with the fully developed gland in pregnancy.


Fc fragment of immunoglobulin G in normal human plasma and urine.


Immunoglobulins and transferrin in marine lamprey sera.


Insulin and the sodium pump of the Maia muscle fibre.


Allotypic specificity of serum protein in inbred strains of rats.


Haemolytic plaque formation by unimmunized mouse peritoneal lymphocytes.


Depression of reticulocytes by gamma globulin after splenic x-irradiation.


A new technique for staining cover slips for fluorescence microscopy.


Anti-gamma globulin agglutinators and gamma globulin factors in multitransfused haemophiliac patients.


The regulatory process in the de-repression of enzyme synthesis. Alkaline phosphatase of Bacillus subtilis. 1. The kinetics of de-repression of alkaline phosphatase in Bacillus subtilis were studied after the removal of P(i). Enzyme activity appeared about 10min. after removal of P(i), whereas ;enzyme-forming potential' appeared after 6min. 2. Protein synthesis is not impaired for at least 20min. on removal of P(i), but RNA synthesis is considerably diminished. 3. Adding chloramphenicol to cells without P(i), just at the time they start to make enzyme-forming potential, does not affect the differential rate of enzyme synthesis compared with total protein. Enzyme-forming potential accumulates to about normal levels in the presence of chloramphenicol, even though peptide-bond formation is inhibited by more than 95%. 4. Similar experiments performed with actinomycin C show more complex effects. Actinomycin initially prevents RNA synthesis and also the synthesis of enzyme-forming potential. After some minutes RNA synthesis resumes at a low rate, to be followed 4min. later by enzyme synthesis. Enzyme-forming potential can accumulate in the presence of actinomycin after the resumption of RNA synthesis. Protein synthesis, initially inhibited by actinomycin as a consequence of the effect on RNA synthesis, is later directly inhibited by actinomycin. 5. Adding actinomycin to de-repressed cells already making enzyme stops enzyme synthesis within 4-5min. Enzyme synthesis resumes, as before, 4min. after the resumption of RNA synthesis. 6. Adding P(i) together with actinomycin to de-repressed cells synthesizing enzyme does not result in a lower yield of enzyme compared with actinomycin alone. 7. Actinomycin is less effective an inhibitor of RNA and protein synthesis in P(i)-starved cells if P(i) is also added. 8. These results are discussed in view of the three main models for the regulation of enzyme induction: regulation at the level of transcription only, at translation only, or a coupled model in which transcription requires concomitant translation. It is concluded that the present evidence most powerfully supports the model of transcriptional regulation.


Extensive degradation of antibody by pepsin.


Affinity labeling of equine anti-beta-lactoside antibodies.


Isolation and characterization of allergens from ragweed pollen. IV.


Heavy-chain subclasses of human gamma-G-globulin. Peptide and immunochemical relationships.


Isolation of a new glycoprotein-a and a gamma-G-globulin from individual cow milks.


The inhibitory effect of uncouplers of oxidative phosphorylation on mitochondrial respiration.


Curare and Alloferin in paediatrics.

Curare and Alloferin in paediatrics.


Divergent responses of serum glycoprotein fractions to tissue injury in adrenalectomized rats.


Study of the interaction of barbiturates and dicumarol and their effect on prothrombin activity, hemorrhage, and sleeping time in rats.


Theoretical aspects of L.S.D. therapy.

Theoretical aspects of L.S.D. therapy.


Special aids for the 1968 National Children's Dental Health Week. Bureau of Dental Health Education.


Electron microscopy of an antibody-hapten complex.


Elimination of normal horse IgG labelled with Iodine-131 in rats receiving horse anti-rat lymphocytic IgG.


Endocrine function in patients with untreated chromophobe adenomas.


Prolongation of allograft survival by an alpha globulin isolated from normal blood.


The clinical use of antilymphocyte globulin in renal homotransplantation.


The association of upper gastrointestinal ulceration and orthotopic hepatic allotransplantation in the dog.


Renal transplantation at the University of Colorado.


Three years' clinical experience with cadaver kidney transplantation.


Instability of the complement system in patients with renal allografts.


Cerebrospinal fluid paper electrophoresis in healthy volunteers.


The cleavage of rabbit immunoglobulin G by trypsin after mild reduction and aminoethylation.


Effects of silver ions on deoxyribonucleic acid-polycyclic hydrocarbon complexes.


Bifunctional reagents and the quaternary structure of proteins.


Stimulation by uncouplers of the efflux of alpha-oxoglutarate from rat-liver mitochondria.


Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa. Methods are described for the isolation and purification of pepsinogen D, a minor zymogen occurring to the extent of about 5% of the potential proteolytic activity in neutral extracts of the pig gastric mucosa. The physical and chemical properties of this zymogen indicate that it is very similar to, if not identical with, dephosphopepsinogen.


Cytochemical studies on DNA-complexes during cell multiplication and cell differentiation.


Projector slide changing and focusing as operant reinforcers. Uninstructed subjects choose to view, in sharp focus where possible, projected visual images in preference to various simpler auditory and visual stimuli (e.g., buzzers of flashing lights). The rate of responding on the lever rapidly increased above the operant level (projector inoperative) even though the stimuli were nonsense syllables. When focusing also was made contingent on responses, the subjects promptly started sharpening the focus of legible but blurred nonsense syllables. When the visual material was colored landscape scenes, the rates of slide-changing generally decreased, because of increased viewing time relative to the nonsense syllables, at the same time that the latencies of focusing decreased. Both the sharpness of focus and the total time spent with the image in sharp focus increased greatly with the colored slides, establishing that the subjects were under control of the stimulus events. Extinction of both responses occurred very rapidly when the controls became inoperative.


An experimental approach to modifying attitude toward patient-care and child-rearing practices.


Quantitative determination of immunoglobins as a diagnostic tool for paraproteinemia.


Renal transplantation in the inbred rat. I. Morphologic, immunologic, and functional alterations during acute rejection.


Synchronisation of oestrus in sheep: the use of pessaries.


The influence of immunologic factors on the development of experimental silicosis in guinea pigs.


Cyanuric chloride for improved cytologic fixation.


Action of papain on normal rabbit immunoglobulin M.


Antibodies to relatively homogeneous haptens: the temporal pattern of their antigen-binding energies.


Treatment of bladder cancer in Egypt. I. General principles and methods of treatment.


Activity of aminopeptidases (amino naphthylamidases) during early limb bud differentiation in the chick embryo.


Distribution of an arginine-lysine interchange in the invariable half of human L-type Bence-Jones proteins.


Aleutian disease gammopathy of mink induced with an ultra-filtrable agent.


Increased IgG synthesis during the induction of immunological paralysis in adult guinea pigs.


Oesophageal abnormalities in Sjögren's syndrome.


Metallophil cells in subcutaneous nodes of Yoshida sarcoma in rats.


Genetic (Gm) determinants of the gamma-2c (Vi) subclass of human IgG immunoglobulins. A study with special reference to Gm(c3) and Gm(c5), and their relationship with the Gm(b) determinants.


Topochemistry of acid carbohydrates in the human aortic and coronary intima.


Cryogenics: the indications and implications for nursing.


Histologic and chemical studies of the smooth muscle in the human cervix and uterus. This study compared chemical and histological measurements of the amount of smooth muscle in the human cervix to determine the extent of correlation of the 2 types of quantifications.  Macroscopically normal uteri and cervical specimens from 31 nonpregnant women, aged 21-55 years, were studied.  Histological estimates were made of muscle amount, and chemical measurements of actomyosin were made.  It was seen that the mean muscle content of the cervix increased from the lower to the upward part.  The smallest amount (6.4%) was in the lower cervix; midcervix muscle content increased to 18%; and upper was 28.8%.  Chemically, the mean actomyosin content of the uterus was significantly greater than that of the cervix (7.54 vs. 3.72 mg/gm) (P=.01).  The 2 types of measurements were correlated in their ability to quantitate muscle mass and amount in the human cervix.


Rupture of the fetal membranes. An experimental, clinical, and histologic study.


Cryoglobulins, rheumatoid factors and connective tissue disorders.


Nucleolar staining in the differentiation of acute leukaemias.


Nursing care in renal transplantation.

Nursing care in renal transplantation.


Determination of neutral urinary 17-oxosteroids with hydroxide of Hyamine 10-x in the Zimmermann reaction.


Ultrathin frozen sections. I. Methods and ultrastructural preservation. A relatively simple method for obtaining ultrathin, frozen sections for electron microscopy has been developed. Tissues, cultured cells, and bacteria may be employed. They are fixed in 1.25-4% glutaraldehyde for 1-4 hr, are washed overnight in buffer at 3 degrees C, and are embedded in 20% thiolated gelatin or pure gelatin. Before sectioning they are partially dehydrated in 50% glycerol, frozen in liquid nitrogen on a modified tissue holder, and subsequently maintained at -70 degrees C with dry ice. Finally, they are sectioned very rapidly with glass knives on a slightly modified Porter-Blum MT-1 microtome in a commercial deep-freeze maintained at -35 degrees C and are floated in the trough of the knife on a 40% solution of dimethylsulfoxide (DMSO). The sections are picked up in plastic loops and transferred to distilled water at room temperature for thawing and removal of the DMSO, placed on grids coated with Formvar and carbon, air-dried, and stained with phosphotungstic acid, sodium silicotungstate, or a triple stain of osmium tetroxide, uranyl acetate, and lead. Large flat sections are obtained in which ultrastructural preservation is good. They are particularly useful for cytochemical studies.


Preservation of myelin lamellar structure in the absence of lipid. A correlated chemical and morphological study. The fine structure of myelin was studied in glutaraldehyde-fixed rat sciatic nerves depleted of lipid by acetone, chloroform:methanol (2:1 v/v), and chloroform:methanol:concentrated HCl (200:100:1, v/v/v). One portion of each of these nerves, plus the extracts, was saponified and analyzed by gas-liquid chromatography for fatty acids. The remainder of each nerve was stained in osmium tetroxide in CCl(4) (5g/100cc) and was embedded in Epon 812. Thin sections, examined in the electron microscope, revealed the preservation of myelin lamellar structure with a 170 A periodicity in nerves depleted of 98% of their lipids. Preservation of myelin lamellar structure depended on glutaraldehyde fixation and the introduction of osmium tetroxide in a nonpolar vehicle (CCl(4)) after the lipids had been extracted. It is concluded that the periodic lamellar structure in electron micrographs of myelin depleted of lipid results from the complexing of osmium tetroxide, plus uranyl and lead stains, with protein.


Endemic goiter in Greece: an iodine balance study in the field.


Serum protein alterations produced in women by synthetic estrogens.


The effect of choriocarcinoma on serum thyroid hormone-binding capacity.


Localization of myoglobin in human skeletal muscle using fluorescent antibody technique.


Preliminary attempts at ultrastructural polysaccharide localization in root tip cells.


Some histochemical observations on transitional epithelium of man.


Glomerular localization and transport of aggregated proteins in mice.


Effects of 1, 1, 3-tricyano-2-amino-1-propene on the pre-and postnatal development of the rat.


Raised levels of a new immunoglobulin class (IgND) in asthma.


Multiple transmissible drug resistance in an outbreak of Shigella flexneri infection.


Replacement of aortic and mitral valves with a pulmonary autograft.


Urinary excretion of calcium and magnesium in patients with calcium-containing renal stones.


Large-dose urography. Is there an optimum dose?


Controlled treatment trials of trachoma in American Indian children.


Von Willebrand's disease associated with intermittent thrombocytopenia.


Pyruvate excretion in diabetes mellitus and non-diabetic patients on corticosteroids after sodium lactate.


Cytological method for assessing the topography of neoplastic cells on the ectocervix.


A test for the bactericidal activity of eye-drops.


Insulin and insulin-like.

Insulin and insulin-like.


The cells in lymph.

The cells in lymph.


Mortality trends for acute and chronic nephritis and infections of the kidney.


Hodgkin's disease in woodworkers.

Hodgkin's disease in woodworkers.


Phytohaemagglutinin in aplastic anaemia.


Inhalation of beta-adrenergic blockers by asthmatics.


5-hydroxytryptophan for depression.

5-hydroxytryptophan for depression.


Macroamylasemia: a newly recognized cause for elevated serum amylase activity.


Globulins in silicotic lungs.

Globulins in silicotic lungs.


Fusion of LLC-MK2 tissue culture cells induced by measles virus.


Aldrich-Wiskott-Syndrome with Thrombocytophagy and Lipopigment in the Reticuloendothelial System.


The use of reduced glutathione for the improvement of the therapeutic effectiveness of blood and plasma substitutes in the treatment of haemorrhagic shock (experimental study).


A rapid turbidimetric method for serum gamma-globulins.


Reticular fibers in Hassall's corpuscles.


Comparative studies of the lymphatic system of four species of amphistomes.


A method for preparing serial paraffin sections of the adult ant brain.


Binding of tritium-labeled polycyclic hydrocarbons to DNA of mouse skin.


Exchange of gamma-globulin between blood, cerebrospinal fluid and brain in the cat.


Genetics and physiology of colicin-tolerant mutants of Escherichia coli. A series of colicin-tolerant (tol) mutants of Escherichia coli K-12, which adsorbed colicins but were not killed by them, were isolated and studied genetically and physiologically. Three major classes of mutants were found: tol II, tolerant to colicins A, E1, E2, E3, and K; tol III, tolerant to A, E2, E3, and K; and tol VIII, tolerant to E1 only. The sites of tol II and tol III mutations mapped near the gal region (gene order: tol-gal-bio) and were cotransduced with gal by P1. In heterozygous diploids, tol(+) was dominant over tol; tol II and tol III gave full complementation. All the tol mutations that mapped near gal rendered the bacteria more fragile during growth and hypersensitive to deoxycholate and to ethylenediaminetetraacetic acid. The tol VIII mutation mapped between str and his. These mutants were extremely sensitive to deoxycholate and were also hypersensitive to methylene blue, acridines, and various other compounds. The sensitivity is attributed to increased uptake due to selective alteration of the permeability barrier. The colicin-tolerant mutations are interpreted as affecting some components of the cytoplasmic membrane which mediate between the adsorbed colicin molecules and the target sites of their biochemical effects in the bacterial cell.


Electron microscopy of a strain of Bordetella bronchiseptica. A strain of Bordetella bronchiseptica that had been isolated from a rat hepatoma cell culture was investigated by means of electron microscopy. Bacteria were examined after (i) negative staining with phosphotungstate or uranyl acetate, (ii) metal shadowing with platinum-palladium, and (iii) fixation with glutaraldehyde followed by embedding, sectioning, and staining. The multilayered bacterial cell walls appeared lobulated in negatively stained and in metal-shadowed specimens; the lobules were demarcated by grooves, 100 to 200 A in width, but without interruption of continuity in any layer of the cell wall. Cross sections of fixed material revealed wrinkled cell walls in many-but not all-preparations. Bacterial cell membranes and cytoplasm were similar to those of other gram-negative bacilli (e.g., Escherichia coli). Bacteria fixed in 1.5% glutaraldehyde contained intertwined or whorled fibrils, down to about 20 A in thickness. The flagella were peritrichous, measured about 200 A in width, and were composed of braided strands, about 20 A in width.


Nephelometric assay of bovine antistaphylocoagulase serum. A nephelometric assay of staphylococcal coagulase has been utilized to measure coagulase inhibition by bovine anticoagulase serum. Suitably diluted antisera produced maximal inhibition when incubated with purified coagulase at pH 7.3 in phosphate-buffered saline for 15 min at 22 C or 1 hr at 4 C. Neutralization of coagulase activity was measured as the reduction in the clotting rate of a fibrinogen-plasma substrate, and was directly proportional to the concentration of antiserum over a wide range of coagulase activity. A unit of anticoagulase was defined as the amount of inhibitor that neutralized one unit of coagulase. In addition to the heat-stable (56 C, 30 min) antibody contained in the crude gamma-globulin fraction, a heat-labile, nondialyzable coagulase inhibitor was also detected in the sera from 15 of 16 randomly selected dairy cows.


Immunochemical studies on glutamate dehydrogenase and on two mutant forms of the protein. Studies on the active product of pepsin digestion of rabbit immunoglobulin G (IgG), F(ab')(2) produced from antiserum against Neurospora glutamate dehydrogenase, showed it to behave in the same way, in both antienzyme and precipitation experiments, as homologous IgG. It is proposed that the inhibition of glutamate dehydrogenase by this antibody preparation is by the same mechanism as proposed for IgG and F(ab), a change in the configuration of the catalytic site brought about by antibodies. Antibodies prepared against two mutant proteins behaved in antienzyme studies in the same way as antibodies prepared against the wild-type protein. It is thought therefore that the antigenic sites on the mutant proteins which initiate the production of neutralizing antibodies were not affected by the mutation which had changed the catalytic properties of the mutant proteins.


Effect of chlormadinone acetate on the body weight of female rats.


Studies on the transfer of myeloma protein synthesis with RNA isolated from the C3H plasma cell tumor (X5563). II. In vivo and in vitro culture of RNA-treated cells.


Studies of the effect of induced immune lymphopenia. I. Enhanced effects of rabbit anti-rat lymphocyte globulin in rats tolerant to rabbit immunoglobulin G.


Adjuvanticity of lactic dehydrogenase virus: influence virus infection on the establishment of immunologic tolerance to a protein antigen in adult mice.


The nature of antibodies and the immune response in rainbow trout (Salmo gairdneri).


Disc electrophoretic patterns of the polypeptide chains of guinea pig immunoglobulins.


The relationship between the Inv (1) and (2) genetic antigens of kappa human light chains.


Physicochemical properties of reaginic antibody. VI. Effect of heat on gamma-E-, gamma-G- and gamma-A-antibodies in the sera of ragweed sensitive patients.


Localization and quantitation of transplantation antibodies.


Immunoglobulin isoantigens (allotypes) in the mouse. IV. Allotypic specificities common to two distinct immunoglobulin classes.


Immunoglobulins of the leopard shark. I. Isolation  and characterization of 17 S and 7 S immunoglobulins with precipitating activity.


An antigenic determinant of human gamma-globulin susceptible to papain digestion.


Mixed gamma G-gamma M cold agglutinin.

Mixed gamma G-gamma M cold agglutinin.


A new serum factor in normal rabbits. 3. Specificity for antigenic determinants uncovered by papain or pepsin digestion.


Utilisation of ammonia nitrogen for protein synthesis in man, and the effect of protein restriction and uraemia.


Histological diagnosis of rejection of renal homografts in man.


Clinical science.

Clinical science.


Virus and Burkitt's lymphoma.

Virus and Burkitt's lymphoma.


Structure and function in idiopathic steatorrhoea.


A protein-free diet for chronic renal failure?


Hydrogen peroxide and gas embolism.

Hydrogen peroxide and gas embolism.


Genetic factors in otosclerosis.

Genetic factors in otosclerosis.


Sudanophilic leucodystrophy with meningeal angiomatosis in two brothers: infantile form of diffuse sclerosis with meningeal angiomatosis.


School medical inspections and the family doctor.


Peripheral nerve glycolipids in metachromatic leukodystrophy.


Ultrastructural features of intracellular lipid in normal human muscle.


Absorption and metabolism of uniformly 14C-labeled phytol and phytanic acid by the intestine of the rat studied with thoracic duct cannulation.


Investigation of glycoprotein material associated with hepatic amyloid.


The characterization of certain alpha globulins in immunoelectrophoresis of human serum, using Evans blue dye.


Electrophoretic study of the in vitro binding of 3,4-benzpyrene to the plasma proteins.


Glomerulopathy and hematoxylin bodies in Rauscher murine leukemia.


Dendritic patterns in the somatic sensory cortex of the cat.


The tangential organization of dendrites and axons in three auditory areas of the cat's cerebral cortex.


Methods for the study of small phagosomes and their relationship to lysosomes with horseradish peroxidase as a "marker protein".


P-hydroquinone and p-benzoquinone as histochemical reagents. I. A new tetrazolium method for amino groups, and the mechanism of formazan staining of paraffin and fresh frozen sections.


An improved silver methenamine technique for the detection of periodic acid-reactive complex carbohydrates with the electron microscope.


Dichroism of cresyl violet-stained cerebroside sulfate ("sulfatide").


Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation. 1. The changes in the rate of histamine formation and in the histamine content of the parietal cell containing region of the gastric mucosa have been studied in rats under the influence of agents which evoke or abolish vagal excitation.2. The hypoglycaemia producing agents, insulin and 2-deoxyglucose (2-DG), raised the mucosal histamine-forming capacity (HFC) in a way similar to that previously observed on re-feeding, gastrin injection, and distension of the stomach wall.3. In cats, insulin injection elicited an elevation of mucosal HFC similar to the corresponding effect of insulin in rats.4. Hoechst 9980, which inhibits post-ganglionic cholinergic transmission, counteracted the elevation of mucosal HFC following vagal excitation, but did not inhibit changes produced by gastrin, thus indicating the absence of a cholinergic intermediary link between gastrin and changes in mucosal histamine.5. It is emphasized that although re-feeding, vagus excitation, gastrin and distension all produce similar changes in mucosal histamine, the clarification of the precise role of histamine as a natural stimulant for the parietal cells may require a fresh kind of approach.


Normal blood values of the adult female monkey (Macaca mulatta).


Histological and histochemical techniques applied to the Agaricales.


Regulatory genes controlling the synthesis of heavy chains of human immunoglobulin-G.


Gamma-globulin foetal bovine sera: significance in virology.


Cholinesterases in a vascular structure in the floor of the fourth ventricle of the cat.


Tissue reactions in the oral mucosa to catgut, silk, and mersilene sutures.


The serological relationship of South African bovine enterovirus strains (Ecbo SA-I and-II) and the growth characteristics in cell culture of the prototype strain (Ecbo SA-I).


A contribution to the problem of the extraneural manifestations of subacute sclerosing leucoencephalitis.


Immunoelectrophoretic analysis of soluble proteins from human spleen.


The presence of the hydrocarbons pristane and phytane in human adipose tissue and the occurrence of normal amounts in patients with Refsum's disease.


Agglutinin-adsorbing latex method for blood-grouping of blood-stains and other specimens.


Cytochemistry of nucleoproteins in malignant cells of primary and secondary tumours.


Topochemistry of enzymes of choroid plexus and ependyma of four animal species. II. Diaphorases and dehydrogenases.


Histochemical investigations of the liver in carbon tetrachloride poisoning.


Enzyme histochemistry in bone tissue. II. Histochemical detection of hydrolytic and oxidative enzymes in callous tissue.


Influence of orotic acid on the hepatic parenchyma. 8. Changes of the localization of acid phosphatase and AS-esterase in the liver after application of orotic acid and vitamin B 12.


Some histochemical changes in the central nervous system of the rat after its surgical damage in different developmental stages.


Cytochemical studies in Trichomonas vaginalis.


A cytospectrophotometric study of some reactions occuring in the lymphocyte nucleus during acute staphylococcal infection in the guinea-pig.


DNA synthesis in the myocardium of growing, mature, senescent and dystrophic mice.


Experimental cholesterine sclerosis as reflected in blood coagulation.


Examination of the anticoagulant and clearing-like effect of serum in experimental cholesterine sclerosis.


In vitro studies on the effect of hexachlorophene and its dimethylether on the liver fluke, Fasciola hepatica L.


Stages in infantile psychosis. A case report.


Skeletal changes in murine runt disease.


Chemotherapy of experimental avian mycoplasma infections.


The interaction of antibiotics, bacteria and the bacterial L-phase in vivo.


Inhibition of mitochondrial respiration by uncouplers of oxidative phosphorylation.


Cold agglutinins, the direct coombs' test and serum immunoglobulins in Mycoplasma pneumoniae infection.


Catecholamine stores and the negative inotropic effect of beta-adrenergic blocking drugs on the isolated rabbit heart.


Modification of mechanical and metabolic actions of sympathomimetic amines on the heart.


Time-dependency of the variations during forced inflations of the respiratory pressure-volume curve in the dog.


Electrical activities in the rabbit vagina.


Effect of infusion of histamine in normal saline and in glucose on gastric secretion in rats with permanent gastric fistulas.


Pharmacologic receptors of an annelid Lumbricus terrestris.


A procedure for the quantitative determination of DNA and RNA in plant tissues.


The absence of cholesterol synthesis in Sepia officinalis L.


Biosynthesis of 3-beta-sterols in a snail, Arion rufus L., from 1-14C-acetate.


Studies on the development of an asynchronism of repolarization in isolated myocardial fibres.


The excitation-contraction coupling during paired stimulation potentiation in conditions of an induced asynchronism of repolarization.


Adrenaline effects on the plateau of the cardiac action potential.


Latency and intracellular distribution of dopamine-beta-hydroxylase in bovine adrenal medulla.


The reaction of 4-(p-trimethylammoniumphenylazo)-2-chloromercuriphenol with the thiol groups of beta-lactoglobulin.


Separation of nucleic acid components on tightly cross-linked Sephadex.


Influence of pH on fatty acid inhibition of methane production by mixed rumen bacteria.


Viral RNA polymerase levels induced in non-permissive "escherichia coli" cells by suppressor-sensitive mutants of bacteriophage MS2.


Interaction between cholesterol and other biological surfactants at interface.


The interaction of trypsin and sodium dodecyl sulfate.


Formation of empty particles from poliovirus by alkaline treatment and by heat.


[Double-stranded RNA from "Escherichia coli" infected with the bacteriophage MS2: the parental RNA-labelled replicative forms and properties of an infectious RNA-containing structure].


The incidence of antibodies to a soluble nuclear antigen in the sera of patients with systemic lupus erythematosus and rheumatoid arthritis estimated with the mixed haemadsorption technique.


The production of immunoglobulins by human peripheral blood lymphocytes in vitro.


Malignant changes in New Zealand black mice.


Inverse effect on the serum levels of gamma-G- and gamma-M-globulins after prednisone treatment of lupoid hepatitis.


Rheumatoid factor in synovial effusions: local production and consumption.


Presence of aggregated gamma-G-globulin in certain rheumatoid synovial effusions.


The occurrence of immunoglobulins in the dermo-epidermal junction of the skin in lupus erythematosus and related syndromes.


Serum ceruloplasmin in liver cirrhosis.

Serum ceruloplasmin in liver cirrhosis.


Evaluation of acaricidal dips for control of Psoroptes ovis on sheep.


Combining the catecholamine fluorescence and methylene blue staining methods for demonstrating nerve fibres.


Iodine transfer and concentration in the prepartum cow, fetus, and neonatal calf.


Intensive coronary care. Arrhythmias after acute myocardial infarction.