Staining method for the examination of the small intestinal villous pattern in necropsy material. A new technique for the rapid identification of villous structure in postmortem material is described. It has been used with success for over a year and has proved superior in the authors' hands to previously described methods.


Value of gel filtration on Sephadex G-200 in the analysis of blood group antibodies. Analysis of blood group antibodies on Sephadex G-200 columns is described. The position of blood group antibodies when whole serum containing them is subjected to gel filtration is studied and compared with the position of the gamma-globulins and of standard blood group antibodies. The technique on its own cannot be used to identify the immunoglobulin nature of the antibody but is very useful when employed in conjunction with the antiglobulin test using specific antisera and with other methods. The technique is rapid, simple, and reliable.


Enteric pathogens in monkeys.

Enteric pathogens in monkeys. From 1964 to 1967, 6,646 monkeys, representing 10 primate species, were examined for Shigella and Salmonella infections upon arrival at the National Center for Primate Biology. Of these animals, 12% were infected with Shigella, and 75% of the Shigella isolates were S. flexneri 4. The incidence of Salmonella infections decreased from 12 to 3% during the period of study. Epidemiological studies of animals in the colony for 90 days or more indicated no seasonal variation in the occurrence of Shigella and Salmonella. Many of the isolates from incoming monkeys as well as from laboratory-conditioned animals were resistant to chloramphenicol, dihydrostreptomycin, and tetracycline. The possible operation of drug-resistance factors in these infections is discussed.


Electron microscopic study of membranes and walls of bacteria and changes occurring during growth initiation. Thin sections of stationary-phase Streptococcus lactis cells showed that the wall and membrane are 20 and 7 nm thick, respectively. Whole cells were examined by negative staining with ammonium molybdate and by shadowing. On air-drying of whole cells, the membrane pulled away from the wall revealing adhesions between these organelles. Adhesions could not be seen after subculture of the stationary-phase cells into complex media or into solutions containing glucose, KCl, and CaCl(2) in tris(hydroxymethyl)aminomethane buffer. The adhesions were also observed in stationary-phase cells of other gram-positive bacteria. Fractured freeze-etched cells of S. lactis had a smooth outside surface, but the inside of the wall (or outside of the membrane) had a regular structure, repeating at 10 nm, which could correspond to the adhesions observed in the negatively stained air-dried cells. Freeze-etching also revealed holes in the outside wall which had the shape of inverted truncated cones. The outside diameter of the cone was 60 nm, and the diameter on the inside surface of the wall was 20 nm. The membrane had upstanding plugs, 20 nm in diameter, which could fill the holes in the wall.


Acute axonal dystrophy caused by fluorocitrate: the role of mitochondrial swelling. Fluorocitrate, a Krebs cycle inhibitor, induices neurons to rapidly expel multitudinous lysosomes, mitochondria, and other cytoplasmic constituents into their axons. After convulsive seizures commence, spectacular axonal balloons develop owing to obstruction of axonal flow by "log jams" of extruded organelles. A swelling of neuronal mitochondria is apparently responsible for the disgorgement of cytoplasmic material into axons.


Relation of anti-gamma-globulin antibodies to transplantation antibodies in human renal allograft recipients.


Karyokinesis of the somatic nucleus of Aspergillus nidulans. II. Nuclear events during hyphal differentiation.


The immunofluorescent skin test in systemic lupus erythematosus.


Protein staining of ribboned epon sections for light microscopy.


Viral hepatitis.

Viral hepatitis.


Viral hepatitis. Immunoglobulin response during the course of the disease.


Stereotaxic thalamotomy for pain relief.


Effect of Cerastes cerastes venom on blood and tissue histamine and on arterial blood pressure.


Autoradiographic analysis of proteins synthesized by human lymphocytes. I. Multiple myeloma and macroglobulinaemia. Evidence relevant to clonal selection theory.


Autoradiographic analysis of proteins synthesized by human lymphocytes. II. Chronic lymphatic leukaemia, lymphoma and lymphosarcoma, Hodgkin's disease, reticulum cell sarcoma and infectious mononucleosis.


Hypofibrinogenaemia with a possibly defective fibrinogen associated with firbinolysis.


Significance of contralateral axillary metastases in carcinoma of the breast.


Intermittent peritoneal dialysis in end-stage renal failure.


Psychiatric aspects of spontaneous abortion. I. A matched control study of women with living children.


Investigation of ureteric function by isotope renography: with particular reference to patients with "unexplained" renal pain.


Effect of the Trendelenburg tilt and other procedures on the position of endotracheal tubes.


The discriminant function in early carcinoma of the breast.


Effect of oral contraceptives on glucose tolerance.


Studies on an iron-binding component in human gastric juice.


IgM metabolism in coeliac disease.

IgM metabolism in coeliac disease.


Effect of brain distension on cerebral circulation.


Fat staining in carious dentin.

Fat staining in carious dentin.


Further evidence for the absence of elastic fibers during movement of the palatal shelves in mice.


Liver transplantation.

Liver transplantation.


Science and people.

Science and people.


The first year of the Abortion Act.

The first year of the Abortion Act.


Asymptomatic hiatus hernia.

Asymptomatic hiatus hernia.


Incontinence.

Incontinence.


From paint to pike?

From paint to pike?


DOPA in Parkinson's disease.

DOPA in Parkinson's disease.


Some experiences of therapeutic abortion.


Return to a hospital in South-East Nigeria.


Psychiatric problems in accident departments.


What should the patient eat?

What should the patient eat?


Current work of Birmingham medical graduates 1959-63.


Conditions in psychiatric hospitals.

Conditions in psychiatric hospitals.


Teaching of radiology.

Teaching of radiology.


Effect of L-DOPA on depression.

Effect of L-DOPA on depression.


Why teach microbiology?

Why teach microbiology?


Oral contraceptives and folate metabolism.


Sex, age, and hyperparathyroidism.

Sex, age, and hyperparathyroidism.


Arvin and platelets.

Arvin and platelets.


Antenatal diagnosis of adrenocortical hyperplasia.


Venous thromboembolism and blood-group.

Venous thromboembolism and blood-group.


Dissimilar adenomas and hyperparathyroidism.


Heparin and protamine in graft rejection.


Clinical haematology.

Clinical haematology.


Nervous-system damage related to hyaline-membrane disease.


Oxygen administration after myocardial infarction.


Lithium.

Lithium.


Induction of labour in rhesus disease.

Induction of labour in rhesus disease.


Hawk or dove?

Hawk or dove?


Fructosaemia-"acute-tyrosinosis".

Fructosaemia-"acute-tyrosinosis".


Oral chlorpropamide in diabetes insipidus.


Aortic hypoplasia: a cause of sudden death?


Skin reaction to vinblastine.

Skin reaction to vinblastine.


A personal medical reference card.

A personal medical reference card.


B.C.G. and the tuberculin test.

B.C.G. and the tuberculin test.


Anti-macrophage component of antilymphocytic serum.


Histochemical diagnosis of Hirschsprung's disease.


Gastroenteritis.

Gastroenteritis.


Histochemical anomaly in myotonic dystrophy.


Macrocytosis in Down's syndrome.

Macrocytosis in Down's syndrome.


Arthur Salusbury MacNalty.

Arthur Salusbury MacNalty.


Effects of adrenalectomy on thyroid function in starved rats.


Wall chart of abnormal values.

Wall chart of abnormal values.


Bitris and his pain: a case study from Nigeria.


Renal lesions in young adoptively immunized NZB/B1 mice.


Refsum's disease: nature of the enzyme defect. Two siblings with Refsum's disease, an inherited disorder of lipid metabolism, oxidized intravenously injected uniformly labeled phytanic acid-C(14) at rates less than 5 percent of those found in normal subjects. The defect in oxidation of phytanic acid persisted in cultures of fibroblasts from the patients' skin. The rate of oxidation of the phytanic acid-C(14) was less than 1 percent of that found in cultures of fibroblasts from normal skin. However, pristanic acid, previously shown to be the first product of phytanic acid degradation, was oxidized at a normal rate in the patients' cultures. These results indicate that the enzymatic defect in Refsum's disease is in the first step of the pathway for degradation of phytanic acid, that is, in the unusual alpha-oxidative process that leads to a shortening of phytanic acid by one carbon atom.


Light chains of rabbit immunoglobulin: assignment to the kappa class. Normal rabbit gamma globulin was reduced under conditions presumed to break only interchain disulfide bridges, and the reduiced product was then blocked with C(14)-iodoacetamide. The light chains were separated from the heavy chains and subjected to peptic digestion. Two radioactive peptides were recovered from the digest. The peptides are apparently overlapping and represent the carboxyterminuis. Comparison of this region in the rabbit light chains with the corresponding amino acid sequences in various mouse and human light chains indicates that the rabbit light chains are of the (K)-class.


White blood cell cultures in genetic studies on the human mucopolysaccharidoses. Cultures of white cells derived from peripheral blood of individuals homozygous and heterozygous for the inherited mucopolysaccharidoses revealed a distinct intracellular metachromatic staining with toluidine blue O. These short-term cultures circumvent the technical problems of skin fibroblast cultures and provide a simple screening procedure to detect the heterozygous state for the mucopolysaccharidoses, as well as offering an opportunity to study the heterozygous state of various inherited storage diseases.


Serum C'3 lytic system in patients with glomerulonephritis. The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C'3 is 80 to 90 percent complete in 20 minutes at 37 degrees C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.


The formation of immunoglobulins by circulating lymphocytes.


Binding of alkali metal ions by cyclic polyethers: significance in ion transport processes. Values for the formation constant (log K), the change in enthalpy (triangle upH degrees ), and the change in entropy (triangle upS degrees ) have been determined for the interaction of lithium, sodium, potassium, rubidium, and cesium ions with the two isomers of the cyclic polyether, 2,5,8,15,18,21-hexaoxatricyclo[20.4.0.0(9,14)] hexacosane. The stability order of these metal ions with either isomer is identical to the permeability order for these same metal ions with the structurally related antibiotics, valinomycin and monactin.


Allopurinol influence on iodine metabolism.


Immunological sex differences. A study of patients with rheumatoid arthritis, their relatives, and controls.


Does the poor immunological reactivity of the thymus really depend on the vascular barrier of Marshall and White?


Loop induction system.

Loop induction system.


The localization of lipids during oogenesis in Anabas scandens (Cuvier).


A new immunoradioactive agent: 32P-conjugated antibody.


Tinker boards--a tactile kinesthetic approach to learning.


Changing nuclear histone patterns during development. II. Isolation and partial characterization of "decapodine" from sperm cells of the crab Emerita analoga.


Calcium kinetic studies in patients with malabsorption syndrome.


The survival and rejection of epithelium in experimental corneal transplants.


Immunoglobulin biosynthesis. I. A myeloma variant secreting light chain only.


Immunoglobulin biosynthesis. II. Four independently isolated myeloma variants.


Immunoglobulin biosynthesis. 3. Blocks in defective synthesis.


Electron microscopy investigation of the structure of cytoplasmic ribosomes of bean leaves.


Leukemia in close relatives--accident or predisposition?


Some observations on the use of gamma globulin to attenuate morbilli.


Psychological diagnostics.

Psychological diagnostics.


Medical grand rounds from the University of Alabama Medical Center.


Mechanism of action of human immunoregulatory alpha globulin.


Antilymphocyte globulin pretreatment combined with azathioprine in the prolongation of dog renal allografts.


A DEAE-cellulose batch technique for antilymphyocyte globulin preparation.


Dispersion staining of human tissues.

Dispersion staining of human tissues.


Transplantation of mouse mammary carcinoma through matrix tissue cultures.


Studies of human leukemia and lymphoma cells by membrane immunofluorescence and mixed hemadsorption tests.


Effects of dietary tryptophan and methionine on protein in the serum and liver of rats.


Fine structural localization of acid phosphatase activity in myeloma cells.


Structure of lettuce necrotic yellows virus. II. Electron microscopic studies on the effect of pH of phosphotungstic acid stain on the morphology of the virus.


Inhibition of induction of interferon synthesis in L-cells pretreated with interferon.


Histological and histochemical observations of the megakaryocyte following ionizing x-irradiation.


The effects of administration of heterologous antithymus serum to New Zealand rabbits.


The binding of iron to plasma proteins-the effects of chelating agents.


Safety of CA-7 (fibrinolytic enzyme) for direct pulmonary artery perfusion.


Detection and estimation of chondroitin sulphate in submicrogram quantities as a complex on acrylamide gel.


A simple staining method for nuclear studies in filamentous fungi.


The fine structure of liver in children with Hurler's syndrome.


Changes in blood coagulation and fibrinolysis in women receiving oral contraceptives. Comparison between treated and untreated women in a longitudinal study. To determine the changes that occur in blood coagulation and fibrinolysis in women receiving oral contraceptives, 23 women were studied before and at regular intervals after starting therapy with oral contraceptives.  In 15 women, blood samples were drawn for analysis after 1, 3, 6, and 12 months of contraceptive usage.  In 8 other women repeated analyses were performed during 2 tablet cycles.  This group's data were compared to an untreated group.  The women received a variety of oral contraceptive preparations.  The parameters examined were: the number of platelets, platelet adhesiveness, fibringen, Factor II, Factor VII, and Factor X activities, Factor VIII, plasminogen and the antifibrinolytic activity of plasma.  In the group of 15 women a significant increase in the plasminogen concentration occurred after 4 months.  At 5-6 months, the number of platelets were significantly increased, but platelet adhesiveness decreased after 2-3 and 5-6 months of usage.  Factors II, VII, and X activities increased after 2-3 and 5-6 months.  Antifibrinolytic activity increased after 5 to 6 months.  In the group of 8 women, considerable variation in the fibrinogen, plasminogen, and spontaneous fibrinolytic activity was observed, with maximal concentration observed during the middle of the tablet period and with minimal concentration  before the start of the next period.  When these cyclic variations were compared to the untreated group, it was discovered that more variation was found in the group receiving oral contraceptives.


Morphologic and cytochemical study on neonatal liver "giant" cell transformation.


The structure and some properties of the isolated mitotic apparatus.


Paraproteinemia in the pregnant woman and in her child. I. Paraproteinemia in pregnancy.


The medical audit in continuing education.


Semantic differential investigation of sexually symbolic concepts.


Influence of HL-A incompatibility on cadaveric renal transplantation.


A method of management of inoperable carcinoma of the bladder.


Lignocaine in the management of ventricular arrhythmias.


Modes of transmission of hepatitis in Melbourne.


A child development approach to language in the preschool disadvantaged child.


Sex differences in the Bender Gestalt performance of children.


Easter Island's stone giants: a neuro-psychiatric view.


Studies on electrophoretic pattern of serum-proteins of buffaloes (Bos bubalis).


Researches on iodine pools of muscular and adipose tissues. A preliminary communication.


Thyroid stimulating substances in human saliva.


Control of persistent ventricular ectopic beats by alprenolol, a new beta-adrenergic blocking agent.


Secretory cells in the middle ear mucosa of the guinea pig. Cytochemical and ultrastructural study.


Circular dichroism studies on native fetuin and some of its derivatives.


Peptide pattern studies on bovine rhodopsin.


Electron microscopy of very low density lipoproteins from egg yolk using negative staining.


Genetics of variability.

Genetics of variability.


Structure and evolution of light and heavy chains of immunoglobulins.


Antibody structure, diversity, and specificity.


Results of radiotherapeutic treatment of relapsing Hodgkin's disease.


Malignant mesothelioma of the tunica vaginalis propria testis. Report of two cases.


Bronchial artery perfusion for treatment of advanced lung cancer.


LHD-isoenzyme patterns in the nonmalignant and malignant uterine cervix.


Show pity for the audience.

Show pity for the audience.


Chemical, electrophoretic and immunochemical studies of the seromucoid fraction of serum: a species comparison.


Patterns of nucleic acid synthesis in the early mouse embryo.


Prostatic and cystic enlargement.

Prostatic and cystic enlargement.


Continuous compression of rabbit articular cartilage producing loss of hydroxyproline before loss of hexosamine.


A combined tissue stain for the selective staining of collagen, elastic fibers and acidic carbohydrates.


Immunologic changes in synovial fluid following synovectomy of the knee for rheumatoid arthritis.


Electron microscope study of the structure of Escherichia coli riboomes and CM-like particles.


A clinical trial of anti-Rho(D) immunoglobulin in the prevention of Rho(D) immunization.


Immunopathologic investigations in lupus erythematosus.


Surgical treatment of patients with cervical disk lesions.


Redox control of lysosomes in human synovia.


Isoimmune anti-IgA causing anaphylactoid transfusion reactions.


Morphological counterparts of functional disturbances of pancreatic islets in aged people and in diabetics. Attempt at correlation.


Use of drugs and intrauterine devices for birth control. The current use of oral contraceptives and intrauterine devices for population control is reviewed including the mechanism of their antifertility actions and the use-effectiveness of each method.  The use-effectiveness of the IUD has been calculated as 1.5-3.0 pregnancies per 100 woman-years of exposure.  The IUD has a high continuation rate (70% after 2 years) and is excellent for poorly motivated population groups.  The most serious common side-effect--pelvic infection--can be controlled by more careful screening and modern antibiotic therapy.  Other side-effects include irregular bleeding and uterine perforation, but not at significantly high levels.  Oral contraceptives have been found to be virtually 100% effective, even in the new lower dose preparations containing around .5 mg progesterone and .05-.15 mg estrogen per tablet.  New hormonal contraceptive approaches include pills which progesterone only, high postcoital estrogen administration, and long-acting injectable progestogen (Depo-Provera).  All of these methods are highly effective but have some undesirable side-effects and require further study.  Careful examination of the recent research reports connecting oral contraceptive use with increased risk of thromboembolism indicate that whatever the danger in oral contraceptive use, the direct physical hazards of pregnancy after  contraceptive failure are much higher and more serious.  Though a 100% safe contraceptive is a desirable ideal, the safety of current oral contraceptives and IUDs is higher than most other aspects of modern life.


Physical and chemical studies on glycoproteins. IV. The influence of sialic acid on the conformation of fetuin.


Enzymatic synthesis of actinocinyl peptides.


Fine structure of protein bodies isolated from rice endosperm.


Further observations on the glucose-induced respiration in Ehrlich ascites cells treated with rotenone.


Cardiac transplantation as palliation of advanced heart disease.


Primary malignant tumors of the small bowel.


The time dependence of the concentration of 5-hydroxytryptamine and staining characteristics of enterochromaffin cells in the human doudenum post-mortem.


Changes of immunoglobulin synthesis in old people.


A reference preparation for human serum immunoglobulins.


Molecular weight of a purified chicken antibody.


Heterogeneity of antibody-forming cells. An electron microscopic analysis. Cell suspensions from draining lymph nodes of immune and nonimmune rats were reacted in vitro with (125)I-labeled antigens. In light microscopic radioautographs of smears, 17% of the immunized cells were tagged by specific antigen; 2.0% of control cells were positive. In electron microscopic radioautographs, 90% of the labeled elements from immune donors were lymphocytes, blast and plasma cells; 10% were monocytes-macrophages or other elements, including naked nuclei. 15% of the labeled cells from control materials were lymphocytes and plasma cells, while 85% were monocytes-macrophages and naked nuclei. Within cell suspensions derived from immunized animals there were almost twice as many lymphocytes marked by isotope as plasma cells, and the lymphocytes ranged in morphology from mature monoribosomal elements to immature polyribosomal cells. Antibody-forming cells fixed labeled antigen at their surfaces. The monocyte-macrophage class was distinguished by a high mean grain count and by distribution of grains within cytoplasmic vacuoles and lysosomes.


Quantitation of IgA and IgM in umbilical cord serum of normal newborn infants.


Metachromatic granules in cultivated fibroblasts derived from patients with genetic disorders.


The mother as source of power. A psychoanalytic study of three Greek myths.


Guided affective imagery (GAI). A method of intensive psychotherapy.


Immunological responsiveness of scrapie infected mice.


The supply and distribution of anti-Rh (D) gamma globulin.


Symbolic aspects of presidential assassination.


Graft versus host reaction in Wiskott-Aldrich syndrome: antemortem diagnosis of human GVH in an immunologic deficiency disease.


Direct antiglobulin consumption test: tests on leucocytes and platelets from patients with malignant disease and some observations on quantitation.


Evolutionary dissociation of gamma G2 and Gm (n) antigens.


Rapid method for the investigation of vaginal cytology.


Modified method for staining tissular mastocytes.


Changes in hematology of the perinatal pig.


Protein concentrations in sputa from asthmatic children. Albumin, lactoferrin, gamma A and gamma G.


Transurethral resection with subarachnoid block. Complication of late hypotension.


Pseudohypoparathyroidism: no improvement following total thyroidectomy.


Survival-times after cardiac allografts.


The genetic factor in pernicious anaemia. A family study in patients with gastritis.


Diagnosis of viral respiratory infections by electron microscopy.


Impaired delayed hypersensitivity in primary biliary cirrhosis.


A metabolic and hormonal basis for classifying ateliotic dwarfs.


Controlled trials of phenobarbitone therapy of neonatal jaundice.


Cardiac transplantation.

Cardiac transplantation.


A controlled trial of dexamethasone snuff in chronic perennial rhinitis.


Thyroxine in blood and tissues.

Thyroxine in blood and tissues.


Halothane: hepatitis or allergy?

Halothane: hepatitis or allergy?


Rifampicin.

Rifampicin.


Hostels for addicts.

Hostels for addicts.


Papilloedema.

Papilloedema.


Family medicine at the Tel Aviv Medical School.


Assault in a mental hospital.

Assault in a mental hospital.


Conditions in psychiatric hospitals.

Conditions in psychiatric hospitals.


Dopa in Parkinson's disease.

Dopa in Parkinson's disease.


Asymptomatic hiatus hernia.

Asymptomatic hiatus hernia.


Aortic hypoplasia.

Aortic hypoplasia.


Clinical haematology.

Clinical haematology.


Isotope renography.

Isotope renography.


Immunoglobulins in injured patients.

Immunoglobulins in injured patients.


Richard Alan John Asher.

Richard Alan John Asher.


Matthew Sydney Thomson.

Matthew Sydney Thomson.


Association of reaginic activity with IgA serum fractions from patients sensitive to grass pollens and house dust.


Lionel Wolman.

Lionel Wolman.


Epidermiologic relationship of age of parents to type and extent of facial clefts.


Attempt at evaluation of functional conditions in the region of cleft lip (employing EMG and EEG examinations).


Growth of the fingers and periods suited for operation on their congenital defects.


Viability of rabbit skin frozen in liquid nitrogen after immersion in liquid paraffin as judged by its growth in tissue cultures.


Reaction of bone, muscle and subcutaenous tissue to lyophilized cartilage grafts.


Plastic operations of ulcers and osteomyelitic fistulae undergoing malignant changes.


Plastic operations in tissue damaged by irradiation.


Transplantation of four toes to hand.

Transplantation of four toes to hand.


Prominent ears: correction with buried mattress sutures.


Subcutaneous silicone granuloma.

Subcutaneous silicone granuloma.


Fluorescent staining for mycobacteria in sarcoid and tuberculous granulomas.


A developmental approach to language disorders.


Four approaches to the diagnosis of perceptual disturbances in reading disability.


A follow-up study of children with disorders of speech (who had received education at the John Horniman school, Worthing).


An experiment in audio and audio-visual group therapy.


An analysis of gastric parietal cell antibodies and thyroid cell antibodies in patients with pernicious anaemia and thyroid disorders.


Visual imagery as a factor in teaching elaborative language to mentally retarded children.


Chromatographic separation of a rat serum growth factor required by Trypanosoma lewisi.


Interference from extraction thimbles in the gas chromatographic analysis of insecticides.


Minnesota percepto-diagnostic test (MPD): age norms and IQ adjustments.


Variability on tests of cognitive and perceptual-motor development in kindergarten children.


Binucleate human oocytes from large follicles.


Marking multiple-choice questions.

Marking multiple-choice questions.


Myokymia with impaired muscular relaxation.


Clinical haematology.

Clinical haematology.


Doxycycline and the teeth.

Doxycycline and the teeth.


Cyclophosphamide in multiple sclerosis.

Cyclophosphamide in multiple sclerosis.


Effects of acute hypernatraemia.

Effects of acute hypernatraemia.


An early use of antilymphocyte serum.

An early use of antilymphocyte serum.


Learning as a basis for a program in human understanding.


Preparing the schools.

Preparing the schools.


Investigations on immunoglobulins in children with enlarged thymus.


Auto-immune hemolytic anemias.

Auto-immune hemolytic anemias.


Rapid diagnosis of viral infections by immunofluorescent staining of viral antigens in leucocytes and macrophages.


A comparison of operative approach for prostatectomy, 1948 and 1968.


Hemostasis in surgical procedures.

Hemostasis in surgical procedures.


The nuclei of the septal area in the cow.


Comparison between chicken and guinea pig thyroid with respect to the incorporation of 131-I in vitro.


Imparting diagnostic information to mothers: a comparison of methodologies.


Sieve plate pores of Nicotiana.

Sieve plate pores of Nicotiana.


Ultrastructural localization and distribution of free cholesterol (3 beta-hydroxysterols) in tissues.


Selective or truncal vagotomy? A double-blind randomised controlled trial.


Hypertension in patients on regular haemodialysis and after renal allotransplantation.


The diagnosis of rejection of renal allotransplants in man.


Relation between Hong Kong virus and former human A2 isolates and the A-EQU12 virus in human sera collected before 1957.


Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo.


Gross fragmentation of cardiac myofibrils after therapeutic starvation for obesity.


Relation between birth-weight and rupture-delivery interval.


Carpal-tunnel syndrome. Results of surgical decompression.


Rapid identification of rubella-virus antigen from throat swabs.


The Marburg agent and structures associated with leptospira.


Plasma-hydrocortisone response to ethanol in chronic alcoholics.


Action of fenfluramine on isolated human smooth muscle.


Chronic heart-block.

Chronic heart-block.


Interpretation of changes in the uterine cervix.


Control of chemotherapy.

Control of chemotherapy.


Pathologists on Zuckerman.

Pathologists on Zuckerman.


Fibrinolysis and deep-vein thrombosis.

Fibrinolysis and deep-vein thrombosis.


Teaching general practice.

Teaching general practice.


An experiment involving substitution of tape-slide programmes for lectures.


Salmonella ponna in Hampshire.

Salmonella ponna in Hampshire.


Psychiatry.

Psychiatry.


Treatment of heroin addiction.

Treatment of heroin addiction.


The first year of the abortion act.

The first year of the abortion act.


Delinquent girls.

Delinquent girls.


Notifying results of abortions.

Notifying results of abortions.


Clinical haematology.

Clinical haematology.


Health services in Latin America.

Health services in Latin America.


Faecal blood-loss after sodium acetylsalicylate taken with alcohol.


Myokymia with impaired muscular relaxation.


Diploma in the history of medicine.

Diploma in the history of medicine.


Immunosuppression and cancer.

Immunosuppression and cancer.


Glucagon therapy in heart-failure.

Glucagon therapy in heart-failure.


Pathogenesis of acne.

Pathogenesis of acne.


Solute load and urine flow in diabetes insipidus.


Mobilisation after myocardial infarction.


Postoperative deep-vein thrombosis.

Postoperative deep-vein thrombosis.


Score for respiratory-distress sydrome.

Score for respiratory-distress sydrome.


Treatment and analysis of the DI George syndrome.


Appetite suppressants and pulmonary hypertension.


Ronald Wilson Fairbrother.

Ronald Wilson Fairbrother.


Moloney lymphoma antibodies from mice; localization in spleens of Moloney lymphoma bearing mice.


Rabbit erythrocyte hemolysis by lipophilic, aryl molecules.


Influence of temperature on the inhibition by colchicine of allergic histamine release.


Gamma-globulin levels of healthy infants in Jakarta.


Determination of milk somatic cells using fluorescence microscopy.


Tonsillectomy: mother's view.

Tonsillectomy: mother's view.


Immunofluorescence of bone marrow specimens in human leukemia and lymphoma.


The phosphatases of peripheral white blood cells in workers exposed to trichloroethylene and perchloroethylene.


Change of cardiac rhythm in the rabbit after an atrial premature beat.


Lactulose: a gas-liquid chromatography method of determination and evaluation of its use to assess intestinal mucosal damage.


Isoelectric focusing of serum proteins in acrylamide gels followed by electrophoresis.


Binding of trace amounts of ionic indium-113m to plasma transferrin.


Hyperthyroidism from the additive effect of unsuppressible thyroid hormonogenesis and administered hormone.


Phosphorylated compounds in erythrocytes frozen with dimethylsulfoxide during 150 days of storage.


Changes of glycolytic intermediates of erythrocytes during storage in acid citrate dextrose medium.


Some questions concerning improvements in blood preservation.


Late addition of inosine to stored ACD-adenine blood. Effects on erythrocyte viability and metabolism.


Electrophoretic pattern of some isoenzymes in reticulocyte preparations.


In-vitro-effect of a Fava Bean extract and of its fractions on reduced glutathione in glucose-6-phosphate dehydrogenase deficient red cells.


Isozymes of human pyruvate kinase.

Isozymes of human pyruvate kinase.


The demonstration of further enzyme abnormality of the erythrocyte membrane in paroxysmal nocturnal haemoglobinuria: elevated adenosine triphosphatase activity.


Electronomicroscopic and cytochemical studies of erythrocytes in hemolytic anemia.


Cardiac hemodynamics in alcoholic patients with chronic liver disease and a presystolic gallop. 10 male subjects with chronic liver disease and with normal cardiovascular findings, except for the presence of a presystolic gallop, underwent right and left heart catheterization. In general, all of the patients had a high resting cardiac output, narrow arteriovenous oxygen difference, a low peripheral vascular resistance, and normal left ventricular end-diastolic pressures and volumes. The plasma volume was increased in the seven patients in which it was determined. On exercise, all of the patients demonstrated a significant increase in the left ventricular end-diastolic pressure and mean pulmonary artery pressure, while the stroke index remained the same or fell in seven of the subjects. It appears logical to assume that the excessive intake of alcohol is associated with an impairment in the metabolic and contractile properties of the left ventricle and the resultant hemodynamic effects may not be readily discerned in the resting state. However, upon exercise these patients, with a congested circulation, can show abnormal cardiac dynamics.


Effect of physiological variations in free fatty acid concentration on the binding of thyroxine in the serum of euthyroid and thyrotoxic subjects. The effect of variations in the concentration of free fatty acids (FFA) on the binding of thyroid hormones in serum has been studied in 20 euthyroid subjects and 19 thyrotoxic patients. In the euthyroid group, neither the pronounced decreases in FFA induced by the oral administration of glucose or the intravenous administration of nicotinic acid, nor the marked increases in FFA which followed the administration of nicotinic acid or 2-deoxyglucose were accompanied by significant changes in the per cent of free thyroxine (T(4)), the protein-bound iodine (PBI), the per cent of endogenous T(4) bound by the T(4)-binding globulin (TBG) or T(4)-binding prealbumin (TBPA), or the resin sponge uptake of triiodothyronine (T(3)). In the thyrotoxic group, the decline in FFA concentration which followed glucose administration was accompanied by slight, but statistically significant, decreases in the PBI and both the per cent and absolute concentration of free T(4). Such changes might have been indicative of an increased intensity of T(4) binding secondary to the decrease in FFA. The serum PBI was decreased, however, a change contrary to that which would be expected to follow an increase in the intensity of T(4) binding. Furthermore, comparable changes in free T(4) and PBI did not accompany the decrease in FFA induced by the administration of insulin. Neither manipulation significantly affected the protein binding of endogenous T(4) or the resin sponge uptake of T(3). It is concluded that within a wide physiological range of concentration, FFA do not significantly influence the transport of T(4) in the serum of euthyroid subjects. In the serum of patients with thyrotoxicosis, FFA may have a slight effect on the binding of T(4), but the nature of any such effect is obscure, since parallel, rather than contrary changes in PBI and the proportion of free T(4) followed alterations in FFA concentration.


Electrophoretic analysis of serum proteins of chickens experimentally infected with Marek's disease agent.


Reduction of immune responses in radiation chimeras. Attempts on their restoration.


General introduction.

General introduction.


Perspectives in organ transplantation.

Perspectives in organ transplantation.


As I see it: O.R. education.

As I see it: O.R. education.


Observations for nursing in relation to the pre- and post-transplant patient.


Surgical nursing and the law 1969.

Surgical nursing and the law 1969.


Member in the spotlight (Miss Volberg Hedbeck).


An OR Technician program.

An OR Technician program.


Fluorescence staining for the determination of cell viability. Primuline was shown to differentiate between viable and nonviable yeast cells taken from certain environments; the technique may be applicable to higher cells.


Normal and defective production of immunoglobulins in the intestinal tract.


Metabolism of 35S-labelled antithyroid drugs in man. Differences in the metabolic fate of antithyroid drugs influence the optimal frequency of administration and their therapeutic efficacy. (35)S propylthiouracil differed from the (35)S imidazoles (carbimazole and methimazole) in the more rapid absorption and excretion and the shorter biological half-life in the plasma of the former. Renal function may have a more important influence on the biological half-life of the drugs than thyroid status. Further work is required to determine the optimal frequency of administration for each compound.


Tetanus in Ontario: a review of the epidemiological and clinical features of 102 cases occurring in the 10-year period 1958-1967.


Identification of microglia in light and electron microscopy.


The immunoglobulins: a review.

The immunoglobulins: a review.


Synaptic patterns of the superficial layers of the superior colliculus of the rat.


Antibody responses to Brucella ovis in maternal and fetal sheep.


Immunologic aspects of experimental Mycoplasma pneumoniae infection.


Immology of the mycoses. II. Characterization of the immunoglobulin and antibody responses in histoplasmosis.


Transurethral prostatic resection without catheter drainage.


Nursing care study.

Nursing care study.


Immunoglobulins of dogs. Identification of seven immunoglobulins and sequence of their antibody response.


Cryosurgery for cancer. An evaluation.

Cryosurgery for cancer. An evaluation.


Transcapsular prostatectomy.

Transcapsular prostatectomy.


Symptomatic control of fever in lymphoma and leukemia.


Total abdominal hysterectomy.

Total abdominal hysterectomy.


Legally hazardous areas of O.R. nursing.


Prevention of rhesus iso-immunisation.

Prevention of rhesus iso-immunisation.


Experimental retinal detachment.

Experimental retinal detachment.


Reaction of centrifugal nerves in the human retina two weeks after photocoagulation.


Histamine cephalalgia--an often overlooked cause of headache.


Surface phenomena of tear films.

Surface phenomena of tear films.


Meesman's corneal dystrophy.

Meesman's corneal dystrophy.


Effect of ACTH on target-organ blood flow, with special reference to an extra-adrenal effect.


Nephrotoxic nephritis in monkeys. Sequential light, immunofluorescence, and electron microscopic studies.


Recurrence of glomerulonephritis in the transplanted kidney.


Prediction of immunoglobulins from patterns of cellulose acetate electrophoresis.


Surgical treatment of congenital aortic stenosis.


Catabolism of rabbit serum gamma globulin aggregates by peritoneal leucocytes and by their granules.


Repeating particles associated with an electrolyte-transport membrane.


Serum proteins, protein-bound iodine and triiodothyronine uptake in the elderly.


Prevention of senile and presenile dementia by bishydroxycoumarin (Dicumarol) therapy.


The development of children borm prematurely with birth weights of three pounds or less.


The overhead projector in a school of radiography.


"Sebaceous cysts" are trichilemmal cysts.


Metabolism of menadione-6,7-3H in the rat.


Equine antihapten antibody. The molecular weights of the subunits of equine immunoglobulins.


The reductive conversion of N-terminal pyroglutamyl into prolyl residues in polypeptides and proteins.


The attachment site of carbohydrate in a mouse immunoglobulin light chain.


Methyl green-pyronin stain for the diagnosis of trachoma.


Immunoglobulins in non-specific ulcerative disease of the colon.


The dynamics of osteon formation in inert bones.


Biologic studies on hamster tumors induced by the murine sarcoma virus (Moloney).


Enhancement by glucose of the inhibition of an Ehrlich ascites tumor by tetraazatricyclododecane.


Centrioles in hepatocytes.

Centrioles in hepatocytes.


Cerebellar cortex of rat and other animals. A structural and ultrastructural study.


On the identity of PAS positive granules and lysosomes in the nerve cells of the rat.


Morphology of neuromuscular spindles in the chicken druing development.


The radiotherapy of pain in patients suffereing from advanced cancer.


Relationship of some blood components to morbidity and mortality in auction calves.


Non-specific inhibition of A2 influenza virus by human sera.


Stimulation of thyroid metabolism by thyrotropin, cyclic 3':5'-AMP, dibutyryl cyclic 3':5'-AMP and prostaglandin E1.


Preparation and evaluation of porcine sera against human immunoglobulins.


Arthritis induced by antithyroid medication.


Statistical methods applied to the diagnosis of hypothyroidism.


The sensitivity to thiacetazone and para-aminosalicylic acid and the virulence in the guinea pig of East African strains of Mycobacterium tuberculosis.


The ethionamide sensitivity of East African strains of Mycobacterium tuberculosis resistant to thiacetazone.


The growth-regulating activity of polyanions: a theoretical discussion of their place in the intercellular environment and their role in cell physiology.


Electrophoresis of human salivary amylase in gel slabs.


Molecular geometry and carcinogenic activity of aromatic compounds. New perspectives.


Neuropsychological bases of schizophrenia.


Splitting of second heart sound in ventricular ectopic beats.


Systemic lupus erythematosus.

Systemic lupus erythematosus.


Molecular expression of evolutinary phenomena in the primary and tertiary structures of cytochrome c.


Histamine release and mast cell degranulation induced by 2,4-dinitrophenol in rat tissues.


The uptake and rate of clearance of 125I gamma-G globulin in lampreys (Lampetra fluviatilis).


Paraproteinemia in the pregnant woman and in her child. II. Transient paraproteinemia in the child.


Fluorescent europium chelate sta.

Fluorescent europium chelate sta. The europium chelate of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (thenoyl-trifluoroacetone; TTA) is firmly bound to microorganisms. It fluoresces brightly at 613 nm with activation at 340 nm. Cells may be stained with 10(-3)m chelate in 50% ethyl alcohol, followed by washing with 50% ethyl alcohol. Equal or better stains are produced with 10(-3)m aqueous europium salt, water wash, and 10(-2)m aqueous TTA. A noncomplexing buffer should be used to maintain the pH at 6.5 to 6.8.


Sympathetic overactivity in tetanus.

Sympathetic overactivity in tetanus.


Have we had Hong Kong flu before?

Have we had Hong Kong flu before?


Contraceptive steroids and sexual activity.


Physiology through the veiw-finder. A review of the status and future of teaching films and television.


Proteins of the amniotic fluid in the light of studies on gamma-globulins.


Immunosuppression.

Immunosuppression.


Quantitative changes occurring in the serum proteins during lactation in the ewe.


The course of naturally acquired helminth infections of horses given regular anthelmintic treatment.


Role of gamma globulin complexes in rheumatoid arthritis.


A study of the cytoplasmic granules in renal papillary interstitial cells in relation to hypertension.


Immunological differentiation of etiologic types of atrophic gastritis.


Congenital cytomegalic inclusion disease. A longitudinal study of 20 patients.


Growth of children with congenital heart disease.


Oxyngen-18 and fluoroproline studies on the synthesis of hydroxyproline and oxoproline in actinomycin.


The flavoproteins of ascites tumor cells.


Immunoglobulins of sheep.

Immunoglobulins of sheep.


Corneal injury produced by carbon dioxide laser radiation.


Ocular complications of infection in the paranasal sinuses.


Uptake of dicoumarol by rat liver mitochondria.


Identification of aerobic heterotrophic soil bacteria to generic level by using multipoint inoculation techniques.


The action of phytohemagglutinin in rabbits. IV. The relationship between the action of PHA-M, PHA-P and antigen.


Comparison of the localization of acetylcholinesterase and non-specific cholinesterase activities in mammalian and avian retinas.


IgA absence associated with short arm deletion of chromosome No. 18.


Sickle cell anemia. (A case report).

Sickle cell anemia. (A case report).


Immunoglobulin abnormalities and current status of treatment of multiple myeloma.


An unusual case of bacterial gingivitis.


An end to cavities.

An end to cavities.


Dental education: the concern of all dentistry.


Army will commission dental hygienists.

Army will commission dental hygienists.


Contoured abutment crown retainers for removable partial dentures.


Dental evaluation of hydromorphone (Dilaudid) for oral and maxillo-facial surgery.


Methodology and evaluation of undergraduate curriculum in obstetrics and gynecology.


Autoradiography with acrylamide gel slab electrophoresis.


Decontamination of empty antilous cotton sacks.


The influence of traffic on atmospheric pollution. The High Street-Warwick.


Complement dependent hemolysis of sheep erythrocytes coupled with non-antibody human IgG.


Histoimmunologic specificity of an anti-lymphoid tissue sarcoma gamma-globulin bound to methotrexate.


Inhibition of release of slow-reacting substance by arsenic.


Segregation of the nucleolar materials produced by quinoxaline antibiotics in JTC-13 cells. Comparison of effects among 4-nitro-quinoline 1-oxide, actinomycin-B, and quinoxaline antibiotics.


Carbon [14C] dioxide evolution from glucose [1-14C] by a microsome-free supernatant of Ehrlich ascites tumor cells.


The lysozyme of bacteriophage lambda. II. Amino acid and end group analysis.


Effects of phenobarbital on the synthesis and degradation of the protein components of rat liver microsomal membranes.


Areas of adhesion between wall and membrane of Escherichia coli.


Turbidimetric method for the assay of antiviral antibodies. A rapid, simple assay method has been developed for antiviral antibodies. The technique has been applied to antisera, immune gamma-globulins, and immunospecifically purified antibody for two strains of influenza virus, Asian 305 and PR8, and to antisera to tobacco mosaic virus. Turbidity changes due to the specific interaction of a virus with its antibody were measured by the increase in optical density in a sensitive wavelength region, e.g., 436 nm. Successful application of the method required that nonspecific effects which give rise to turbidity changes be eliminated. This was accomplished by proper choice of ionic strength (0.3 m) and pH (5.5), and by the addition of normal serum or serum albumin to the virus before contact with the antibody. Sensitivity of the method allowed quantitation of antibody down to the level of 10 mug of antibody protein per ml. The specificity of the reaction causing the turbidity change was established by experiments which showed that precipitation of virus-antibody complexes removed the reactive component in the serum, and by the absence of turbidity changes for nonspecific pairs (virus plus unrelated antisera).


Gamma A-gamma G mixed cryoglobulin.

Gamma A-gamma G mixed cryoglobulin.


Urinary excretion of calcium and magnesium in primary hyperparathyroidism.


Portal bacteraemia in cases of ulcerative colitis submitted to colectomy.


Heparin and human lipid metabolism.

Heparin and human lipid metabolism.


Neonatal hepatitis: a new syndrome?

Neonatal hepatitis: a new syndrome?


The water story.

The water story.


Genetics in the aetiology of disease.

Genetics in the aetiology of disease.


More effects of cigarettes.

More effects of cigarettes.


Teaching of psychiatry.

Teaching of psychiatry.


Treatment of tetanus.

Treatment of tetanus.


Failure of cervical cytology?

Failure of cervical cytology?


Waiting for Broderick.

Waiting for Broderick.


Induced abortion and Rh-isoimmunisation.


Coeliac disease in a diabetic child.

Coeliac disease in a diabetic child.


Nosocomial brachial palsy.

Nosocomial brachial palsy.


Treatment of gastric mycosis.

Treatment of gastric mycosis.


Controlled trial of propranolol in thyrotoxicosis.


Successful treatment of three cases of very severe barbiturate poisoning.


Increased incidence of tetracycline-resistant pneumococci in Liverpool in 1968.


Managment of functioning thyroid cancer.


Goitre: seasonal fluctuations in New South Wales.


The identification of the high-risk patient in Rhesus sensitization by the use of post-partium foetal cell counts.


Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli.


The multimedia approach to teaching nursing.


Steps to learning.

Steps to learning.


A picture is still worth more than a thousand words.


Audiovisual communications: some pro's and con's.


Methodological aspects of cerebrospinal fluid immunoelectrophoresis.


The dorsal root distribution to the substantia gelatinosa of the rat with a note on the distribution in the cat.


Silver impregnation of degenerating dendrites, cells and axons central to axonal transection. II. A Nauta study on spinal motor neurones in kittens.


Nodular lymphoid hyperplasia of the small intestine and hypogammaglobulinemia.


The disruption of lysosome-like particles of Solanum tuberosum cells during infection by Phytophthora erythroseptica Pethybr.


The extraneous coat of lung alveoli.

The extraneous coat of lung alveoli.


Prevention of varicella by zoster immune globulin.


Passive immunization against chicken pox.


Tetanus.

Tetanus.


Group therapy with young psychotic children.


Skin reactions to anti-gammaE antibody in atopic, nonatopic, and immunologically deficiency children and adults.


Cellular and chemical changes during myelination: histologic, autoradiographic, histochemical and biochemical data on myelination in the pyramidal tract and corpus callosum of rat.


Luteinizing hormone levels in plasma and urine in women during normal menstrual cycles and in women taking combined contraceptives or chlormadinone acetate.


Isohemagglutinins in parasitic infections.


Effect of race and stage of disease on the serum immunoglobulins in sarcoidosis.


The use of the nomarski interference system in microscopic studies of somatic cells in bovine milk and other body fluids.


The effect of iodination on the activity and structure of acid phosphomonoesterase from human prostate.


Parafollicular cells of the thyroid as studied with Davenport's silver impregnation.


Response of incurable endometrial cancer to progesterone withdrawal.


Permeability of lung capillaries to macromolecules in foetal and new-born lambs and sheep. 1. The permeability of lung capillaries to macromolecules was investigated in immature and mature foetal lambs, new-born lambs and young sheep. The placental circulation of the foetal animals was maintained intact after delivery by Caesarian section. New-born lambs and sheep were mechanically ventilated. Samples of plasma and lymph that had drained from the lung via the thoracic duct were collected over a period of 1-5 hr.2. The proteins in plasma and lymph samples were separated by fractionation on columns of Sephadex G-200. Plasma yielded three peaks of protein concentration. The K(av) value of each peak was determined, and, by calibrating the columns with known proteins, the mean radius of equivalent sphere (a) of the proteins in peak I was shown to be similar to that of fibrinogen >/= 110 A, peak II to gamma-globulin approximately 54 A and peak III to albumin approximately 34 A. Lung lymph contained the same three constituent peaks as plasma but in lower concentration. In all four groups mean lymph/plasma concentration (L/P) ratio was significantly different for each of the three peaks, being lowest for the largest molecules (peak I) and highest for the smallest (peak III).3. In five mature foetal lambs polydisperse polyvinylpyrrolidone labelled with (125)I ([(125)I]PVP) was injected I.V. early in the experiment: count rates in fractionated samples showed for plasma a continuous decline with time after injection, and for lung lymph an increase to a maximum then a decline. Steady-state L/P ratios for eleven fractions of PVP of differing molecular size ranging from 110 to 17 A were derived by compartmental analysis. For a given molecular size PVP L/P ratios were similar to protein L/P values.4. The regression of PVP L/P ratio on K(av) was linear (correlation coefficient r = 0.99), and the slope of the regression of protein L/P ratio on K(av) was significantly steeper for new-born lambs than for mature foetuses (P < 0.025) and sheep (P < 0.005), and steeper for immature foetuses than sheep (P < 0.01).5. PVP and protein L/P ratios (mature foetuses) plotted against a showed a sigmoid relation with agreement between the two sets of L/P ratios. The goodness of fit between our experimental results and Landis & Pappenheimer's (1963) capillary pore theory (eqn. (1)) was examined: L/P ratios for the larger molecules (>/= 75 A) appeared to be too high. By recalculating ratios on the assumption that the largest molecules (110 A) escape unrestricted from the capillary via leaks, the discrepancy disappears.6. Values for pore radius (r), and pore area per unit path length (A/Deltax) have been calculated for each of the four groups; r ranged from 90 to 150 A, A/Deltax from 3.3 to 0.2 cm x 10(3).kg(-1). In new-born lambs the value of r was significantly smaller, and A/Deltax larger than that of any other group. The inferences to be drawn from these results are discussed.


Immunopathological aspects oa ataxia telangiectasia.


Haemathological and electrophoretic studies in the course of experimental fasciolosis.


Thyroid allografts implanted in the marrow space of rabbits. A functional and morphological evaluation.


Diagnostic use of infant cry.

Diagnostic use of infant cry.


Structural analysis of a slowly sedimenting proteolytic fragment of human immunoglobulin M.


Biologic activity and morphology of three types of rabbit IgM antibody subunits.


Antigen-induced cell proliferation in cultures from antibody-deficient chickens.


The effect of intravenous antigen on circulating monocytes in animals with delayed hypersensitivity.


A comparative antigenic study of gamma E-globulin and myeloma-IgND.


Studies on brain antigens. II. Water soluble antigenic proteins of bovine brain.


Histamine release from human leukocytes by anti-gamma E antibodies.


A method for the immunoadsorption of cells to an antibody-coated polyurethane foam.


Use of thymectomized, irradiated rats to study immunogenicity of bovine gamma globulin.


Immunoglobulins of the Rhesus monkey (Macaca mulatta). 3. Structure and activity of rhesus IgG and IgM antibodies synthesized in the primary response and in the hyperimmune state.


Cytochemical studies on chromosome ultrastructure.


A new staining procedure for electron microscopical cytology.


Early traumatic epilepsy. Definition and identity.


Jejunal atresia in twins with presumed congenital rubella.


Recovery in Landry-Guillain-Barré syndrome after prolonged respiratory support.


D-xylose absorption before and after portasystemic venous anastomosis.


Lipoid proteinosis in an inbred Namaqualand community.


Inheritance of high blood-pressure in the spontaneously hypertnsive rat.


Dietary osteomalacia.

Dietary osteomalacia.


Acute salicylate poisoning.

Acute salicylate poisoning.


Local radiation protection.

Local radiation protection.


Prognosis in multiple sclerosis.

Prognosis in multiple sclerosis.


An ABC of medical genetics. II. Chromosomes and chromosome mutations.


Should diabetis marry?

Should diabetis marry?


Conditions in psychiatric hospitals.

Conditions in psychiatric hospitals.


Survivl-times after cardiac allografts.

Survivl-times after cardiac allografts.


Maintenance dose of Arvin.

Maintenance dose of Arvin.


Health services in Latin America.

Health services in Latin America.


Herpes-like virus.

Herpes-like virus.


Body-weight, food, and energy.

Body-weight, food, and energy.


Fragmentation of cardiac myofibrils after therapeutic starvation.


Induction of labour in rhesus disease.

Induction of labour in rhesus disease.


The first year of the Abortion Act.

The first year of the Abortion Act.


The signed-rank (Wilcoxon) test.

The signed-rank (Wilcoxon) test.


Control of chemotherapy.

Control of chemotherapy.


Aphasia in thalamic haemorrhage.

Aphasia in thalamic haemorrhage.


Release of free fatty acids from canine subcutaneous adipose tissue by histamine and compound 48-80.


Genetic study of cystic fibrosis of the pancreas using white blood cell cultures.


Neurological syndromes associated with pes cavus.


Immunity to protozoal infections.

Immunity to protozoal infections.


Humoral and cellular responses to gram-negative infections.


Microheterogeneity of the testosterone binding globulin of human pregnancy serum demonstrated by isoelectric focusing.


Testosterone binding globulin: an attempt at its purification.


The steroid binding beta-globulin in plasma: pathophysiological data.


Sex differences in the incidence of tumours at various sites.


Amyloidosis--a complication of pustular psoriasis. Two patients with generalized pustular psoriasis developed amyloidosis with a fatal outcome. It is suggested that generalized pustular psoriasis may predispose to the development of secondary amyloidosis either by prolonged stimulation of the reticuloendothelial system or through abnormal immunoglobulin synthesis.


On the morphology and subdivision of the cerebellar nuclei of the rat.


Binding of tritiated actinomycin and cell differentiation.


A plan for physician education and communication.


The psychoanalytic theory of dreaming--1968.


Quantitative studies on enzymes in structures in striated muscles by labeled inhibitor methods. I. The number of acetylcholinesterase molecules and of other DFP-reactive sites at motor endplates, measured by radioautography. Di-isopropylfluorophosphate (DFP) labeled with phosphorus-32 was applied to fragments of the diaphragm and sternomastoid muscles of the mouse, in conditions in which it saturated all available sites at the motor endplates. After adequate washing and exchange with unlabeled DFP, single endplates were obtained by microdissection and their radioactivity was found by beta track radioautography. The number of sites phosphorylated by DFP-(32)P per endplate was relatively constant for each muscle: in the sternomastoid, about 9 x 10(7) sites per endplate, in the diaphragm, about 3 x 10(7). Reaction with DFP-(32)P was abolished by prior treatment with unlabeled DFP. Labeling was unaffected by prior fixation in formaldehyde, but was inversely proportional to the time of incubation in the Koelle staining medium, when this preceded labeling. The contribution of acetylcholinesterase (AChase) to this total number of DFP-reactive sites was determined by three methods. The first involved reactivation of the phosphorylated AChase by pyridine-2-aldoxime methiodide (2-PAM), in conditions in which the reactivation of other enzymes would be insignificant. The other two methods involved protection of the active centers of AChase from phosphorylation by labeled DFP by use of 284C51, an inhibitor highly specific for this enzyme, or by use of eserine. Each of these methods indicated that about 35% of the DFP-reactive sites at endplates of the sternomastoid and diaphragm are AChase. The mean number of AChase molecules was thus found to be 3.1 x 10(7) and 1.1 x 10(7)per endplate in sternomastoid and diaphragm, respectively. No significant reaction of labeled DFP with muscle and nerve was observed. Mast cells in the muscle had a concentration of DFP-reactive sites far higher than the endplates.


Visuals for a television course in anatomy and physiology.


Differential effect of polycyclic hydrocarbons on the demethylation of the carcinogen dimethylnitrosamine by rat tissues.


Eight-millimetre colour sound film loops in physiology and pharmacology.


Simultaneous demonstration of ileal mucosa cell types.


Student perception of the instructional value of visual illustration.


Pushkin and Parricide: The Miserly Knight.


Duchamp's Young Man and Girl in Spring.

Duchamp's Young Man and Girl in Spring.


The eagle and the axe: a study of Whitman's "Song of the Broad-Axe".


A rapid phloxine B method for demonstratin Mallory bodies in liver sections.


Ultrastructural aspects of Paget's disease of the vulva.


Dentistry in Denmark.

Dentistry in Denmark.


Correlation between the antigenic and catalytic properties of staphylococcal nuclease.


Nassau County's Health Department Library.


The cause of the myocardial "hyaline degeneration" induced in rats fed predominantly maize diets supplemented with either the NNRI food formulae or skimmed-milk powder.


Some molecular aspects of antibody formation.


The immunofluorescent "band" test for lupus erythematosus. I. Morphologic variations of the band of localized immunoglobulins at the dermal-epidermal junction in lupus erythematosus.


Hyaline reticuloxanthoma. A new mesodermal tumor.


Rapid contrast stain as a diagnostic aid for fungous infections.


A new insecticidal isomer of hexachlorocyclohexane (BHC).


Effect of glucocorticoid treatment on calcium-activated rat liver mitochondrial adenosinetriphosphatase.


Origin and migration of facial muscle primordia and their significance in development of the cranial nervous system.


A heart transplantation. 8. Immunological and haematological aspects.


Placental transfer of group A type-specific streptococcal antibody.


Splenectomy in childhood and the hazard of overwhelming infection.


Maturation and aging changes in rabbit spermatozoa isolated by ligatures at different levels of the epididymis.


Operative technique for transposition of the great vessels with previous Baffes' procedure.


Feline anaphylaxis: some observations.

Feline anaphylaxis: some observations.


Ganglion, amacrine and horizontal cells of the cat's retina.


The additive to the analgesic.

The additive to the analgesic.


Detection of immunoglobulins in calf sera.


Effects and metabolism of hormones in normal and neoplastic prostate tissue.


Immunologic "short circuits".

Immunologic "short circuits".


Long-acting thyroid stimulator and exophthalmos.


Total abdominal hysterectomy.

Total abdominal hysterectomy.


Possible respiratory sites in a blue-green alga Nostoc sphaericum as demonstrated by potassium tellurite and tetranitro-blue tetrazolium reduction.


Kynurenine formamidase in rat skin. Partial purification and characterization.


The role of plasma transport proteins in hormone homeostasis, with particular reference to thyroid hormone.


Task relevance and auditory evoked responses.


Electrophysiology of "epileptic" neurons: spike generation.


The alpha average. 3. Clinical application in children.


Initial EEG signs of a developing epileptic focus: the precursor slow wave.


A comparison of EEG modifications induced by coagulation of subthalamus, preoptic region and mesencephalic reticular formation.


Effect of penetrating wounds upon the electrical activity of the brain.


Interhemispheric spread of drug-induced electrical cortical activity.


EEG changes in subgaleal hematomas.

EEG changes in subgaleal hematomas.


Selective amplification of neural spike responses.


A comparison between scalp and needle electrodes for the EEG.


Are there brain systems related to specific situations?


Which computer?

Which computer?


Digital analysis of the EEG in coma.

Digital analysis of the EEG in coma.


A n automatic EEG monitor using analogue techniques.


Analysis of EEG activity recorded from electrodes implanted in deep structures of the human brain.


Cerebral response to sinusoidally modulated light in man.


Topographic observations on visual pattern-evoked potentials.


Analysis of evoked responses to sinusoidally modulated light.


On-line Fourier analysis of steady-state evoked potentials to alternating wave length stimuli.


Evoked responses to acceleration and to tachistoscopic presentation of patterned visual stimuli.


Evoked cerebral sensory responses in relation to complexes and other EEG activity; further observations with particular reference to arousal complexes and other phenomena of sleep in man.


Harmonics in visual evoked responses.

Harmonics in visual evoked responses.


Automatic analysis of EEG topography with an analogue computer.


Changes in the amplitude probability function of the EEG under varying normal conditions.


Output integration of broad-band frequency analysis (time interval histogram with the aid of a data retrieval computer).


The occurrence of spontaneous sleep in healthy subjects in long-term serial EEG recordings.


Integration of methods of investigation in cerebral processes.


Periodic changes of the EEG associated with changes of intracerebral haemodynamics during sleep.


Serial EEG studies on patients receiving various forms of ECT.


Blood calcium and the EEG.

Blood calcium and the EEG.


Blood flow in deep brain structures as determined by local rheosubcorticography in patients with various forms of epilepsy and hyperkinesia.


Electrical activity of human subcortical structures in drowsiness and sleep (a study combining visual analysis and processing of data by computer).


Clinical and EEG analysis of the role of subcortical structures in the mechanisms of aphasia and anosognosia.


Concerning the problem of pathogenesis and treatment of Raynaud's syndrome and disease.


Dynamics of integrated electrical activity of the brain in sleeping man.


Electrophysiological and pharmacological analysis of reaction to self-stimulation.


Concerning the reciprocal forms of bilateral disturbances of electrical activity in focal lesions of the brain.


Neurophysiological mechanisms of ascending activating influence of the hypothalamus on the cerebral cortex in fasting.


Variations of the level of steady potential in deeper structures of the human brain in sleep.


Mechanism of adrenalin and aminazine action on the direct application to the midbrain reticular formation.


Electrophysiological analysis of the effect of aminazine on the cerebral activating system.


Some crucial points in investigation of the neurophysiological basis of human mental activity.


Mechanisms of regulation of neuron excitability.


The effect produced by novocaine and products of its breakdown on some structures of the limbic system and on the nucleus caudatus.


Synaptic transmission of nervous processes.


Ionic mechanisms of excitation and inhibition.


Background and evoked impulse activity of neurons.


Some data on oxygen dynamics in subcortical structures of the human brain.


Electrophysiological characteristics of the hypothalamic and frontal parts of the alimentary centre.


Concerning functional interrelations in subcortical structures and between the latter and the cortex in hyperkinetic patients.


The effect of hypothalamic stimulation on the propagation of somato-sensory evoked potentials over cerebral cortex.


Pecularities of functional relationship between the hypothalamus and the brain-stem reticular formation.


Concerning the electrical activity of the brain in children with diencephalic syndrome.


Control of walking and running by means of electrical stimulation of the mesencephalon.


Pharmacological analysis of EEG desynchronization reactions to afferent stimuli in man.


Concerning the influence of non-specific brain-stem structures on the vegetative functions of the brain in cerebral pathology.


Dynamics of cellular activity of subcortical structures of the human brain during certain motor and psychological tests.


Concerning the role of thalamic structures in the genesis and regulation of alpha rhythm.


Electrical activity of the thalamus, amygdaloid nucleus and hippocampus in some forms of epilepsy.


Thyroid hormone secretion rate and biological half-life (t one half) of L-thyroxine-131 I in the musk shrew (Suncus murinus).


Evaluation and treatment of shock, respiratory failure.


Inhibition of adjuvant arthritis by protein antigens. I. Inhibitory capacities and dose relationships of different proteins.


Studies on the antigen reacting with the thyroid-stimulating immunoglobulin (LATS) in thyrotoxicosis.


A reference preparation for human serum immunoglobulins.


'Nuclear' antigens and antinuclear antibodies in mink sera.


Ultrastructural studies of carcinoma of the human prostate gland.


On the active site of alpha-chymotrypsin. Absolute configurations and kinetics of hydrolysis of cyclized and noncyclized substrates.


Studies on the alpha oxidation of phytanic acid by rat liver mitochondria.


Morbid conditions at death in old men.

Morbid conditions at death in old men.


Observations on the postnatal development of Clarke's column in the kitten.


Quantitative estimation of human immunoglobulins. I. Estimation of IGG, IGA and IGM immunoglobulins by the method of simple radial immunodiffusion.


Effect of TSH on the 24-hr 131-I uptake in Graves' disease.


Detection of antibody activity.

Detection of antibody activity.


A "Lepore" type of hybrid gamma-globulin. No explanation has been available concerning the gamma globulin defect in a unique family with one member whose serum was devoid of all the usual Gm genetic antigens. In the present study, it was found that this serum lacks ordinary gammaG1 and gammaG3 proteins and contains instead hybrid molecules of the type gammaG3-gammaG1. These were demonstrated most clearly by the precipitation of gammaG1 proteins with antisera specific for gammaG3 antigens. The analogy to the delta-beta chain hybrids, established for Lepore-type hemoglobins, was striking. An unequal homologous crossover involving mispairing of heavy chain cistrons would readily explain the deletion of genetic markers.


Staining technique in disc electrophoresis for disclosing absence of normal serum proteins in patients with hematologic neoplasms.


Fibrinolysis and coagulation. Effect of calcium and of coagulation on the lysis of fibrin clots.


The uterine cervix as a potential local antibody secretor.


Use of the Souttar tube in the management of advanced esophageal cancer.


Serum immunoglobulins in healthy children and in children with chronic recurrent upper respiratory tract infections.


Late systolic sounds in health.

Late systolic sounds in health.


Lysosomal changes in epithelial cells of the mouse thymus after hydrocortisone treatment.


The effect of hydration of the rabbit cornea on the histochemical demonstration of acid mucopolysaccharides.


The replicative organization of DNA in polytene chromosomes of Drosophila hydei.


Ontogenetic development of the complement system.


Production of different classes of immunoglobulins by individual cells in the guinea-pig.


Cytolysis of mouse lymph node cells by alloantibody: a comparison of guinea-pig and rabbit complements.


Analysis of soluble antigens in guinea-pig epidermis. II. Physico-chemical characterizations of tissue-specific antigens.


The immune response suppressed by specific antibody.


A new allotypic antigen of rabbit colostral gamma A immunoglobulin.


The serologic diagnosis of rheumatoid arthritis. The latex-rabbit gamma-globulin fixation test.


Isolation and characterization of free gamma chain of immunoglobulin produced by an established cell line of human myeloma cell origin. I. Gamma chain in culture medium.


Immunologic unresponsiveness in the adult guinea pig. IV. Induction of unresponsiveness with aggregated serum proteins.


Alterations in immune responses by attenuated Venezuelan equine encephalitis vaccine. I. Adjuvant effect of VEE virus infection in guinea pigs.


Pattern of immunoglobulin production in individual cells of human hematopoietic origin in established culture.


Evaluation of human rabies immune globulin and homologous and heterologous antibody.


Superior vena cava replacement. Report of a successful autogenous composite vein graft.


Palliative treatment in tricuspid atresia. Combined balloon atrioseptostomy and surgical alteration of pulmonary blood flow.


Death from weight-control pills. A case report with objective postmortem confirmation.


Insulin and glucose studies after one year of treatment with a sequential-type oral contraceptive. Plasma insulin and blood glucose were measured during an intravenous glucose tolerance test at the University of Minnesota hospital clinic on 28 women on oral sequential contraceptives (15 tablets of 80 mu-g mestranol, 5 tablets of 80 MCG  mestranol and 2 mg chlormadinone acetate) both prior to drug initiation and after 1 year of use.  No statistical difference in either glucose or insulin levels or weight change was seen after 1 year of therapy.  A significant positive association was found between the elevation of glucose and insulin with the drug at cerain time periods during the glucose test, and if there was a family history of diabetes mellitus.  A higher frequency of abnormal glucose and insulin levels has been found among users of combination-type drugs as compared to the sequential type.


Relationship between regional aortic susceptibility to atherosclerosis and macromolecular structural stability.


Electron microscopy of tissues stained by the osmiun-iodide technique of Champy-Maillet. Preliminary report.


Principles of the application of antirabies serum.


Histochemical studies in pulmonary oxygen toxicity.


Automated ultramicro-estimation of total serum protein and protein fractions, with the changes due to renal tract disease in children with spina bifida.


Methylcholanthrene-induced thyroiditis. Susceptibility of buffalo strain rats.


Serum proteins in post-kala-azar dermal leishmaniasis.


Studies on proteins and antibodies in the sera of smallpox cases.


Prevention of Rh immunization.

Prevention of Rh immunization.


Bronchodilator action of pentaerythrityl tetranitrate in experimental pulmonary embolism.


The transformation of human lymphocytes by monkey antisera to human immunoglobulins.


The production of two molecular classes of antibody in the toad, Xenopus laevis, homologous with mammalian gamma-M (19S) and gamma-G (7S) immunoglobulins.


Isolation and identification of oxoproline in actinomycin X2. (V). Hydrolysates.


Study of ruptured fetal membranes by Nile blue sulfate staining.


Endocrine studies in patients with the "empty sella syndrome".


Serum glycoproteins in naturally acquired malaria in man.


Whipple's disease with cardiac and renal abnormalities.


Our experience with sequential estrogen-progestin treatments to inhibit ovulation.


Results of treatment of stomach cancer. An appraisal of efforts for more extensive surgery and a rort of 1,983 cases.


The presence of delayed hypersensitivity reactions in patients toward cellular extracts of their malignant tumors. 1. The role of tissue antigen, nonspecific reactions of nuclear material, and bacterial antigen as a cause for this phenomenon.


Cryosurgery for tumors of the head and neck.


Differentiation of hepatic and hematopoietic cells and synthesis of blood serum proteins in organ cultures of the liver.


Clinical neuropathological conference.

Clinical neuropathological conference.


The isolation and preliminary analysis of the hyaline layer of sea urchin eggs.


The intracellular location of the adenine- and thymine-rich component of deoxyribonucleate in testicular cells of the crab, Cancer productus.


Studies on the effect of protamine sulfate on cells of Vicia faba roots.


Effects of inhibition of ribosomal RNA synthesis on the stimulation of lymphocytes by phytohaemagglutinin.


Transneuronal degeneration in brains of monkeys asphyxiated at birth.


Adverse reactions following administration of human gamma globulin.


Studies on isopropyl-imidazolidine-thione: a potent goitrogen.


Localization of the oxidative defect in phytanic acid degradation in patients with Refsum's disease. The rate of oxidation of phytanic acid-U-(14)C to (14)CO(2) in three patients with Refsum's disease was less than 5% of that found in normal volunteers. In contrast, the rate of oxidation of alpha-hydroxyphytanic acid-U-(14)C and of pristanic acid-U-(14)C to (14)CO(2), studied in two patients, while somewhat less than that in normal controls, was not grossly impaired. These studies support the conclusion that the defect in phytanic acid oxidation in Refsum's disease is located in the first step of phytanic acid degradation, that is, in the alpha oxidation step leading to formation of alpha-hydroxyphytanic acid. The initial rate of disappearance of plasma free fatty acid radioactivity after intravenous injection of phytanic acid-U-(14)C (t(1/2) = 5.9 min) was slower than that seen with pristanic acid-U-(14)C (t(1/2) = 2.7 min) or palmitic acid-1-(14)C (t(1/2) = 2.5 min). There were no differences between patients and normal controls in these initial rates of free fatty acid disappearance for any of the three substrates tested. There was no detectable lipid radioactivity found in the plasma 7 days after the injection of palmitic acid-1-(14)C or pristanic acid-U-(14)C in either patients or controls. After injection of phytanic acid-U-(14)C, however, the two patients showed only a very slow decline in plasma lipid radioactivity (estimated t(1/2) = 35 days), in contrast to the normals who had no detectable radioactivity after 2 days. Incorporation of radioactivity from phytanic acid-U-(14)C into the major lipid ester classes of plasma was studied in one of the patients; triglycerides accounted for by far the largest fraction of the total present between 1 and 4 hr.


Refsum's disease: characterization of the enzyme defect in cell culture. Refsum's disease (heredopathia atactica polyneuritiformis, HAP) is an inherited neurological disorder associated with storage of the branched-chain fatty acid, phytanic acid (3,7,11,15-tetramethylhexadecanoic acid). Cultured fibroblasts derived from skin biopsies of HAP patients did not contain elevated levels of phytanate, yet showed rates of phytanate-C-(14)C oxidation less than 3% of those seen in cells from control subjects. Cells of control subjects converted phytanate to alpha-hydroxyphytanate, to pristanate (the [n-1] homologue of phytanate) and to 4,8,12-trimethyltridecanoate, compounds previously identified as intermediates on the major pathway for phytanate metabolism in animals, providing the first direct evidence that this same oxidative pathway is operative in human cells. None of these breakdown products could be found after incubation of phytanate with HAP cells. Labeled alpha-hydroxyphytanate and labeled pristanate were oxidized at normal rates by HAP cells. Oxidation of the latter proceeded at normal rates both when added to the medium at very low tracer levels and at levels 100 times greater. Phytanate was incorporated into and released from lipid esters at normal rates by HAP cells. Elevated levels of free phytanate in the medium were no more toxic to HAP cells than to control cells over the 48- to 72-hr exposures involved in these studies, as evidenced by morphologic criteria and by ability to oxidize labeled palmitate. These findings are consistent with the hypothesis that the cells from HAP patients are deficient in a single enzyme involved in the alpha-hydroxylation of phytanate, while the enzymes involved in later steps are present at normal or near-normal levels.


On the nature of the high iron diamine method for sulfomucins.


Electron microscopic demonstration of zinc in the hippocampal formation using Timm's sulfide silver technique.


Minor joint trauma.

Minor joint trauma.


Sociology and medicine separation or symbiosis?


Chlormadinone acetate as oral contraceptive. A clinical trial.


Practical and theoretical implications of fetal-maternal lymphocyte transfer.


Use of antibiotics in acute gastroenteritis among infants in hospital.


Heparin therapy in the haemolytic-uraemic syndrome.


Serum lipids and lipoproteins in untreated diabetic children.


Thyrotoxic hypercalcaemia treated with porcine calcitonin.


Teaching resources for patient education.


Cold-insoluble complexes and complement levels in systemic lupus erythematosus.


Cancer palliation by solid tumor chemotherapy. 1.


Clinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts.


Studies of the immunologic defects associated with intestinal lymphangiectasia, with some observations on dietary control of chylous ascites.


The application of multicompartmental analysis to problems of clinical medicine. Combined clinical staff conference at the National Institutes of Health.


Drug treatment of thyrotoxicosis.

Drug treatment of thyrotoxicosis.


Lymphoblastic leukaemia.

Lymphoblastic leukaemia.


An immunochemical study of plasma cells in the intestinal mucosa in adult coeliac disease.


A new case of alpha chain disease, presenting as a malabsorption syndrome.


Ribonucleic acid synthesis in nuclei isolated from rat liver.


Luteal function in the merino ewe and the effect of exogenous progestagen.


Studies on the G cells of the pyloric mucosa, the probable site of gastrin secretion.


Tactile perception of direction and number in patients with unilateral cerebral disease.


Primary amenorrhea secondary to noncommunicating hydrocephalus. Case report.


A peculiar polysaccharide accumulation in muscle in a case of cardioskeletal myopathy.


A new carmine staining technique for fungal nuclei.


Cryosurgery of the prostate.

Cryosurgery of the prostate.


The role of lipids in acid-fastness of mycobacteria.


Cytologic manifestations of the phagocytosis of L1210 chromosomes by L1210 cells in culture.


Changes in serum proteins in the immediate postoperative period.


Cytochemical studies on the oogenesis of Dytiscus marginalis L.


Histologically demonstrable bound lipid apparently associated with relatively stable, mature collagen fibres.


The mast cells in the brain of the triturus pyrrhogaster (Boie). I. The histologic studies.


The nasal drop addict.

The nasal drop addict.


Cinematography of brain structures prepared by perfusion staining.


Differential staining of aborted and nonaborted pollen.


Brazilin-toluidine blue O and hematoxylin-darrow red methods for brain and spinal cord.


Synthetic orcein as a stain for chick embryo cartilage matrix.


The use of acrylamide gel in immobilizing alizarin-stained skeletal preparations.


Preparation of brain slices for macroscopic study by the copper sulfate-phenol-ferrocyanide technique.


Chromosome preparations from mouse embryos during early organogenesis: dissociation after fixation, followed by air drying.


Studies of the 131-I3 test using acetalized polyvinyl alcohol sponge as adsorbant. (II).


As I see it: O. R. education.

As I see it: O. R. education.


Surgical care of the child: a new challenge for the operating room nurse.


Evolution, revolution or renaissance?

Evolution, revolution or renaissance?


Orientation and staff development in a general hospital.


"In vitro" preparation of crab gill for use in ion transport studies.


A method permitting prolonged and repeated studies of rat's gastric secretion.


Formation and excretion of ammonia in Teleostei. II. Occurrence and transort of ammonia in the blood.


Reflex responses induced in the human finger flexor muscles by rhythmical strch of the muscle.


Strontium action potentials in cardiac Purkynĕ fibers.


Use of glycylglycine-14C to determine dipeptidase activity.


Structural differences in normally and poorly iodinated thyroglobulin.


The base sequence at the 5'-terminus of bacteriophage Q-beta RNA.


Alanyluracils in plants.

Alanyluracils in plants.


The aminoacid sequen of the coat protein of the bacteriophage MS-2 and localization of the amber mutation in the coat mutants growing on a su+3 suppressor.


Mechanism of action of thyrotrop through the cyclic 3',5'-AMP system.


Localization of the bicarbonate and carbonate pools by whole-body autoradiography.


Mechanical activity of frog's heart in sucrose solutions.


The influence of the rate of infusion on the kalemotropic effect of epinephrine.


Liver phosphorylase and its regulating enzymes during ontogenesis of the chick embryo.


Coupling between Cl flux and Na or K flux in cardiac Purkynĕ fibers. Influence of pH.


Capacitance reactions of isolated veins to monoamines and acetylcholine.


The heterogeneous decomposition of nitric oxide on supported catalysts.


The hypothalamic distribution of the stria terminalis in the rat.


Quantitative analysis of the cerebral cortex. I. Aselectivity of the Golgi-Cox staining technique.


Immunologic response with reference to the humoral changes in surra.


Further investigation on the organic-inorganic relationships in calcifying cartilage.


Stimulation of biosynthesis of tobacco mosaic virus by antimetabolites.


Hepatitis antigen. Correlation with disease and infectivity of blood-donors.


Human infection with the agent of feline pneumonitis.


Systemic fat embolism associated with the toxic effects of aviation-fuel inhalation and general anaesthesia.


Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction.


Oral zinc sulphate in leg ulcers.

Oral zinc sulphate in leg ulcers.


Growth-hormone response to oral glucose in children with simple obesity.


Prediction of malignancy in solitary thyroid nodules.


Dynamic and static lung volumes, blood-gas tensions, and transfer factor in chronic obstructive bronchitis.


Dermatoglyphic defects in children with leukaemia.


Stimulation of insulin secretion in vitro by essential aminoacids.


Insulin and atheroma.

Insulin and atheroma.


New drugs against tuberculosis.

New drugs against tuberculosis.


War and peace.

War and peace.


Human gonadotrophins in the treatment of infertility.


Pregnancy diagnosis.

Pregnancy diagnosis.


Boys before the courts.

Boys before the courts.


Rubella vaccines.

Rubella vaccines.


The genes.

The genes.


Psychiatric unit in a district general hospital.


Tapes-slides or lectures?

Tapes-slides or lectures?


Therapeutic abortion.

Therapeutic abortion.


Rifampicin.

Rifampicin.


Thyroxine in blood and tissues.

Thyroxine in blood and tissues.


Iron-binding component in human gastric juice.


Psychiatric problems in accident departments.


Lithium.

Lithium.


Phenobarbitone for neonatal jaundice.

Phenobarbitone for neonatal jaundice.


L-asparaginase and blastogenesis.

L-asparaginase and blastogenesis.


Resistance of Pseudomonas aeruginosa.

Resistance of Pseudomonas aeruginosa.


Antenatal diagnosis of adrenocortical hyperplasia.


Experience at a burns centre.

Experience at a burns centre.


Reaction to trifluoperazine abuse.

Reaction to trifluoperazine abuse.


Luteinising hormone in XYY men.

Luteinising hormone in XYY men.


A homozygous chromosomal variant.

A homozygous chromosomal variant.


Fragmentation of cardiac myofibrils after therapeutic starvation.


Subacute sclerosing panencephalitis.

Subacute sclerosing panencephalitis.


Robert Thomson Leiper.

Robert Thomson Leiper.


Sydney Alfred Smith.

Sydney Alfred Smith.


James Blair Hartley.

James Blair Hartley.


Ernest McMurchie Dunlop.

Ernest McMurchie Dunlop.


Thomas Lionel Hardy.

Thomas Lionel Hardy.


Emlyn Evans Lewis.

Emlyn Evans Lewis.


Nursing care for thoracic surgical diseases.


The occurrence of glycogen-membrane complexes in fungi. An electron microscope study.


Centenary: Charcot's other joints.

Centenary: Charcot's other joints.


FII haemagglutination test for serum antigammaglobulin factors in arthritides sero-positive and sero-negative by other tests.


Electrophoresis of human saliva and identification of inherited variants of amylase isozymes.


Management message emphasized by visual training aids.


Hyaline corneal opacities in a case of Rieger's anomaly.


The requirement of more than one antigenic determinant for immunogenicity. Rabbits primarily stimulated with a BSA (bovine serum albumin)-sulfanilic acid complex will produce a good secondary response to the sulfanilic acid hapten if the carrier used in the secondary stimulus is again BSA, and not if the secondary carrier is HGG (human gamma globulin). In the latter situation, a good secondary response is obtained, however, if the rabbits are pretreated a few weeks earlier with free HGG. We conclude that the immune stimulus involves the recognition of carrier determinants unrelated to the hapten. As the receptors for recognition of unrelated determinants are probably situated on different cells, we suggest that the immune stimulus leading to antibody formation requires the interaction of two antigen-bridged cells.


The effects of heterologous anti-thymocyte sera in mice. 3. High susceptibility of germfree mice to the suppressive effects of IgG from rabbit anti-mouse thymocyte serum. A quantitative graft-vs.-host (GVH) assay was used to compare the reactivity of spleen cells from germfree (GF) and conventionally reared (CV) mice against allogeneic tissue before and after treatment with rabbit anti-mouse thymocyte serum (ATS) and its IgG fraction (AT-IgG). AT-IgG produced a far greater and longer lasting suppression of this reactivity in GF than in CV mice. Moreover, CV mice recovered from suppression twice as rapidly as did GF mice. In both groups, the rate of recovery was exponential. These results suggest that recovery from the suppressive effects of ATS or AT-IgG was the result of generation of new cells. Transfer of mice born and initially reared in a conventional animal room to germfree isolators, with subsequent maintenance on the same diet that the germfree mice received, did not change the reactivity of their spleen cells in the assay used nor their susceptibility to AT-IgG. Removal of GF mice to a conventional animal room resulted in a prompt reduction in susceptibility to AT-IgG. The possibility that this might be related to the elaboration of a plasma factor affecting lymphocyte stability was discussed. Spleen cells taken from GF mice at various times after such "conventionalization" showed a transient but marked hyperreactivity to tissues of the allogeneic recipients. The amount of reduction in reactivity of spleen cells from such mice treated with AT-IgG was always proportional to the activity of spleen cells from comparable untreated mice. It was suggested that the increased reactions evoked should be ascribed to an adjuvant effect rather than to specific immunologic sensitization. Blood lymphocyte counts correlated very poorly with the state of suppression, confirming previous observations. It was also shown that while AT-IgG had little or no effect on blood granulocyte counts in both GF and CV mice, marked reductions in circulating granulocytes followed administration of AT-IgG during the period of increased granulocytopoiesis that resulted from conventionalization. This demonstrated that AT-IgG can produce functional impairment of target cells other than lymphocytes.


Antibody and immunoglobulin production at the cellular level in bursectomized-irradiated chickens. The effect of bursectomy combined with sublethal X-irradiation in the newly hatched chicken on the immunoglobulin and antibody producing capacity in later life was investigated. The previous findings of a significant incidence of hypogammaglobulinemia in such animals were confirmed. Spleen cells from severely hypogammaglobulinemic animals synthesized and secreted little or no immunoglobulin. Such spleen lymphoid cells contained fewer immunoglobulin antigenic determinants than spleen cells from irradiated control animals as evidenced by their relative inability to respond by an increased DNA synthesis after in vitro culture with rabbit antiserum to chicken immunoglobulin. Therefore, the deficiency in the immunoglobulin synthesis extends not only to actively secreting cells such as plasma cells, but to the entire lymphoid cell population. As expected, most irradiated-bursectomized chickens, irrespective of plasma immunoglobulin levels failed to produce detectable amount of circulating antibodies to Brucella abortus antigen in the primary immune response. Severely hypogammaglobulinemic animals were completely unable to elaborate any plaque forming cells (PFC) in the primary response to sheep red blood cells (SRBC). The results of this investigation support the contention that in the severely hypogammaglobulinemic bursectomized-irradiated chicken the entire antibody producing and immunoglobulin producing cell line is absent. The possibility remains that precursor or stem cells are present but are not appropriately directed to antibody synthesis by other cell types.


Temperature changes induced by imidazoline sympathomimetics in the rat.


The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors. The role of serum factors in the phagocytosis of pneumococci was studied employing a spectrophotometric assay which measures reduced nitro blue tetrazolium (NBT) dye. Dye reduction occurs within the phagocyte shortly after bacterial ingestion as measured by the phagocytic index technique and by the uptake of (125)I-pneumococci. Bacteria prepared with gammaG antibody were not phagocytosed unless a small volume of fresh normal serum was added. Using fresh sera deficient in single complement components, it was demonstrated that the first four components are necessary for optimal bacterial phagocytosis. When highly purified complement components were added to the antibody-coated pneumococci, enhancement of phagocytosis was achieved only with the sequential addition of C1, C4, C2, and C3. Evidence has been presented that human C3 bound to an immune complex exhibits peptidase activity and that this activity is essential for phagocytosis. A heat-labile, dialyzable serum cofactor which enhances C3 peptidase activity enhanced the phagocytosis of pneumococci prepared with purified complement components. A second phagocytosis-promoting cofactor, which is not a complement component, was found to be a heat-labile, 5-6S, beta pseudoglobulin. This protein may stabilize C3 peptidase activity or inhibit enzymatic inactivation of C3.


Management of ventricular fibrillation outside hospital.


First-year follow-up after recovery from acute myocardial infarction with complete heart-block.


Transfer of antibiotic resistance from animal and human strains of Escherichia coli to resident E. coli in the alimentary tract of man.


Pulmonary disease due to inhalation of derivatives of Bacillus subtilis containing proteolytic enzyme.


Phlebotomy and iron-overload in porphyria cutanea tarda.


Allergic reactions of the lungs to enzymes of Bacillus subtilis.


Relative changes in free-fatty-acid and glucose utilisation by ischaemic myocardium after coronary-artery occlusion.


The haemorrhagic diathesis of heatstroke. A consumption coagulopathy successfully treated with heparin.


Proofed poplin and balloon cloth in a wrap-around operating-gown.


Prednisone-induced leucocytosis in nephrotic syndrome.


Organic dusts and allergic lung diseases.


Experimental renal hypertension.

Experimental renal hypertension.


Gains and losses.

Gains and losses.


A vaccine withdrawn.

A vaccine withdrawn.


Abdominal aortic aneurysms.

Abdominal aortic aneurysms.


Catecholamines and the heart.

Catecholamines and the heart.


The role of the paediatrician in adoption medical practice.


The frequency of conditions due to mutant genes of large effect.


Cadmium toxicology.

Cadmium toxicology.


Lithium.

Lithium.


Oral contraceptives and depression.

Oral contraceptives and depression.


Thyroxine in blood and tissues.

Thyroxine in blood and tissues.


Treatment of insulinoma with streptozotocin.


Treatment of tetanus.

Treatment of tetanus.


Insulin and atheroma.

Insulin and atheroma.


Localization of urinary-tract infection.


Leucocyte-migration inhibition in autoimmune diseases.


Dermatoglyphics of leukaemic children.

Dermatoglyphics of leukaemic children.


Control of growth-hormone secretion.

Control of growth-hormone secretion.


Fat embolism.

Fat embolism.


Oral zinc sulphate in leg ulcers.

Oral zinc sulphate in leg ulcers.


New drugs against tuberculosis.

New drugs against tuberculosis.


Resistance of Pseudomonas aeruginosa.

Resistance of Pseudomonas aeruginosa.


Urinary calcium and magnesium in hyperparathyroidism.


Coeliac disease in a diabetic child.

Coeliac disease in a diabetic child.


Fragmentation of cardiac myofibrils after therapeutic starvation.


Hepatitis antigen.

Hepatitis antigen.


Psychiatric unit in a general hospital.

Psychiatric unit in a general hospital.


Carpal-tunnel syndrome.

Carpal-tunnel syndrome.


Biochemical assessment of protein-calorie malnutrition.


Withdrawal of anticoagulant therapy?

Withdrawal of anticoagulant therapy?


Polyunsaturated fatty acids in ruminant tissues in relation to atheroma in man.


Self-help bed-handles.

Self-help bed-handles.


Winifred Ferguson Young.

Winifred Ferguson Young.


Alterations in liver RNA induced by atropine and disulfoton.


Serum levels of immunoglobulin A (IgA) in atopic patients.


The Chediak-Higashi syndrome: continuous suspension cultures derived from peripheral blood.


Gnotobiotic pigs: procurement, microbial flora, serum proteins and lymphatic tissues.


Studies on the transfer of thio-oxazolidone-type goitrogens into cow's milk in goitre endemic districts of Finland and in experimental conditions.


Two types of Sertoli cells in man.

Two types of Sertoli cells in man.


In vitro uptake of tritiated testosterone and oestradiol by the lateral lobe of the hypertrophied human prostate and the accessory sex glands of the rat--a pilot study.


On the vascular lesions of thrombotic thrombocytopenic purpura with special reference to its pathogenesis.


Blood-fibrinolysis during chrysotherapy.


Dermal-epidermal junction in lupus erythematosus.


Problems of play and mastery in the blind child.