In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. A technique for the in vitro culture of rheumatoid synovial tissue with (14)C-amino acids and isolation and quantitation of the newly synthesized immunoglobulins has been developed. This technique has been used to compare immunoglobulin synthesis of 12 rheumatoid synovia with that of synovia from nonarthritic patients and with that of normal human lymph nodes and spleen. In addition, the spleen of a patient with Felty's syndrome has also been examined. Immunoglobulin synthesis in rheumatoid synovia has been shown to be quantitatively and qualitatively similar to that of normal human spleen and lymph nodes although somewhat less active than the Felty's syndrome spleen examined. 79% of the immunoglobulin produced in rheumatoid synovia was of the IgG type, whereas IgM comprised 10% and IgA, 11% of the total. Less than 10% of the IgM synthesized was found to be rheumatoid factor. A fraction containing approximately 90% of its radioactivity in the form of IgG has been obtained for further studies.


Antithyrotoxic factor content of various roughages and cow feces based on repression of induced liver malic enzyme in thyrotoxic rats.


Iodinated phenylalanines. Tests for selective localization in pancreas and preparation of 3,4,5-triiodophenylalanine.


Effect of C'1 esterase on vascular permeability in man: studies in normal and complement-deficient individuals and in patients with hereditary angioneurotic edema. When purified human C'1 esterase is injected intradermally in man, increased vascular permeability results. This effect is not blocked by soybean trypsin inhibitor and is not abolished by pretreatment with the antihistamine, pyribenzamine, or by compound 48/80. Thus, the effect is not due to the release of endogenous histamine. The decreased permeability response of individuals with a specific hereditary deficiency of C'2 is evidence for the complement-dependent nature of this reaction. The apparently normal response to intradermal C'1 esterase developed by individuals with an acquired specific deficiency of C'3 suggests that the vasoactive substance may be derived from one of the early reacting complement components. Characteristic attacks of angioedema have been provoked by the intradermal injection of human C'1 esterase in two individuals with hereditary angioneurotic edema. Patients with hereditary angioneurotic edema are unresponsive to intradermal injections of C'1 esterase immediately after attacks.


The case for perineal prostatectomy.

The case for perineal prostatectomy.


Full-color and three-dimensional effect in radiographic displays.


Events in the natural history of prostate cancer: using salvage curves, mean age distributions and contingency coefficients.


Hypoxaemia in bronchial asthma.

Hypoxaemia in bronchial asthma.


Cyclic drug regimen for acute childhood leukaemia.


Recurrent monocular blindness of uncertain cause.


Changes in the life-span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin.


Investigation and treatment of amenorrhoea developming after treatment with oral contraceptives.


Frequency of satelliting of the human chromosomes 21 and 22 and the identity of the mongol chromosome.


Urinary oestrogen in late pregnancy. Oestriol excretion as a guide to impending foetal death before term.


Practicability and cost of oestriol assays for saving babies in amternity hospital.


Furazolidone in the treatment of cholera.


Intestinal absorption in protein-calorie malnutrition.


Intravenous chlormethiazole in pre-eclamptic toxaemia in labour.


Unusual chromosomes and malignant disease.


A new look at the D.P.H..

A new look at the D.P.H..


Replication of genetic material in a test-tube.


Test-tube organ cultures of ciliated epithelium for the isolation of respiratory viruses.


When to leave school?

When to leave school?


Who goes where.

Who goes where.


Carbohydrate metabolism in the newborn.

Carbohydrate metabolism in the newborn.


Value for money in hospitals.

Value for money in hospitals.


Measles in Africa.

Measles in Africa.


Bacteriology in the surgery.

Bacteriology in the surgery.


Spinal sensory-motor seizures.

Spinal sensory-motor seizures.


Radiation dose in isotope encephalography.


Splenic aspiration in acute leukaemia.

Splenic aspiration in acute leukaemia.


Ammonia nitrogen and protein synthesis.

Ammonia nitrogen and protein synthesis.


Automated screening for cervical smears?


Dynamics of the common duct.

Dynamics of the common duct.


Systemic infections in heroin addicts.

Systemic infections in heroin addicts.


Immunoglobulins in the newborn.

Immunoglobulins in the newborn.


Serum enzymes and uric acid during treatment with amiloride.


Cytomegalovirus infection and infantile spasms.


Urinary insulin in the newborn.

Urinary insulin in the newborn.


Cultivating leukaemic lymphocytes.

Cultivating leukaemic lymphocytes.


Chromosomes 21-22 and neutrophil alkaline phosphatase in leukaemia.


A tragic moving-staircase mishap.

A tragic moving-staircase mishap.


Performance of hospitalized male alcoholics on the Kahn test of symbol arrangement.


Localization of slow potential responses in the Necturus retina.


Institutionalized infants' concept formation ability.


Induction of experimental glomerulonephritis in the rat by homologous major urinary protein.


Assay of circulating immunoglobulins in patients with fibrosing alveolitis.


A nuclear staining artefact in immunofluorescence.


Humoral immunity in congenital rubella.

Humoral immunity in congenital rubella.


Rapid continuous determination of nitric oxide concentration in exhaust gases.


The need for a pollution-free vehicle.

The need for a pollution-free vehicle.


Metabolism of gamma-G-globulin in the nephrotic syndrome in adults.


The role of melatonin in the regulation of thyrotrophin secretion.


Studies of the insulin-like activity of serum. II. Characterization of insulin-like activity of serum protein fractions from normal human subjects.


Studies on the insulin-like activity of serum. 3. The influence of the pancreas on the insulin-like activity of serum.


Longitudinal EEG and clinical study of children with febrile convulsions.


Neuronal development and ontogeny of evoked potentials in auditory and visual cortex of the dog.


Post-reinforcement electrocortical synchronization and facilitation of cortical auditory evoked potentials in appetitive instrumental conditioning.


Comparison of reticular and cochlear multiple unit activity with auditory evoked responses during various stages induced by anesthetic agents. II.


Meperidine-induced changes in the maternal and fetal electroencephalograms of the guinea pig.


Electrophysiological studies of central nervous performance during monotony.


A multi-channel isolated stimulator.

A multi-channel isolated stimulator.


The rapidity of EEG time changes during mental function.


Phase analysis differences in left, mixed and right preferent groups.


Spatial display and parameter computation of the human epileptic spike focus by computer.


Coherence as a measure of relationship between EEG records.


A neuropathological study of a case of petit mal epilepsy.


Routine computer analyses of clinical EEG's with the aid of automatic curve reader for ink recordings.


Time-course analyses of quantitated EEG amplitude relationships between cerebral structures in cats and rabbits.


The study of eye movements during waking and drowsiness.


The Lennox-Gastaut syndrome: a severe type of childhood epilepsy.


The polyphasic spike phenomenon.

The polyphasic spike phenomenon.


The EEG in establishing brain death. A 10-year report with criteria and legal safeguards in the 50 states.


Visual evoked potentials to colored light in normal controls and light sensitive epileptics.


Age and barbiturate induced fast asymmetries of the EEG.


Measures of evoked response similarity.

Measures of evoked response similarity.


The comparative ontogenesis of visually evoked responses in rat, cat and human infant.


Some interactions of the vertex potentials.


Cortex and scalp recorded somato-sensory evoked potentials in man.


Comparative topography of visual, auditory and somatic cerebral evoked responses in normal man.


Changes in somato-sensory evoked potentials during the contingent negative variation (CNV).


Electroencephalographic correlates of preparation set.


Anxiety, stress and contingent negative variation (CNV).


Evaluation of the electroencephalogram of dyslexic children.


The Jacksonian hypothesis: a re-appraisal in the light of single unit recording in focal epileptogenic gray matter of man.


Auditory cerebral deafferentation and epileptogenicity.


H reflex studies and the effects of intravenous diazepam(valium) in subacute sclerosing leucoencephalitis.


The differentiation of tranquilizers by quantitative EEG.


Analysis of electroencephalographic correlates of human sensori-motor processes.


Response to sine wave modulated light in normal subjects and in patients.


The light sensitive epilepsy of Papio papio. Topographic study of cortico-subcortical electroencephalographic paroxysmal activity.


Contributions of the intracarotid sodium amytal and metrazol tests to the understanding of the mechanism of "centrencephalic" epilepsy.


Comparative effects of hypothalamic stimulation on neocortical and hippocampal EEG in rostral midbrain transected cats and effects of some adrenergic and cholinergic agonists.


The study potentials in chronic experimental epilepsy.


Inhibition in focal epileptogenesis.

Inhibition in focal epileptogenesis.


Sequential functional changes in single cortical neurons during spreading cortical depression.


Intracellular potentials of motor cortex neurons in cerebral ischemia.


The DC field in the cortex beneath an epileptic focus.


Possible cortical neurotransmitters as defined by micro-iontophoresis.


Biogenic amines and the EEG.

Biogenic amines and the EEG.


Amino acids released from the cortical surface in cats following stimulation of the mesial thalamus and midbrain reticular formation.


Cholinergic mechanisms and the EEG.

Cholinergic mechanisms and the EEG.


Progress in the clinical application of evoked potentials. Introduction and methodologic considerations.


Clinical applications of evoked potential techniques in infants and children.


Progress in the clinical application of evoked potentials in hearing problems.


Clinical application of visual evoked responses.


Some problems of measurement of the evoked potentials.


Conjunct interpretation of serum 131I-triiodothyronine binding and protein bound iodine as indices of thyroid function in patients with abnormal thyroxine-binding globulin levels.


Thyroid physiology in lambs as affected by iodine supplementation of the pregnant ewe's diet.


Acute glomerulonephritis following skin infection due to streptococci of M-type 2.


Intracranial haemorrhage and clotting defects in low-birth-weight infants.


Immunoglobulins and rubella-virus antibodies in adults with congenital rubella.


Airways obstruction before and after isoprenaline, histamine, and presnisolone in patients with chronic obstructive bronchitis.


Antinuclear antibodies in infectious mononucleosis.


Effect of gluten-free diet on dermatological, intestinal, and haematological manifestations of dermatitis herpetiformis.


Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy.


Topical triamcinolone acetonide in recurrent aphthous stomatitis. A clinical trial.


Salicylate ingestion and idiopathic hair loss.


Antilymphocyte serum in the later stages of experimental allergic encephalomyelitis.


A portable incubator for long-distance transport of cultures.


Pathogenesis of heart-failure in acute-on-chronic respiratory failure.


Acute glomerulonephritis and skin sepsis.


The cause of glandular fever.

The cause of glandular fever.


X rays and childhood cancer.

X rays and childhood cancer.


Bed or armchair?

Bed or armchair?


Cold water for burns and scalds.

Cold water for burns and scalds.


The nicotine habit.

The nicotine habit.


Crisis in American medicine.

Crisis in American medicine.


Hospital medical staff. Time for structural alteration?


Diazepam for treatment of phobias.

Diazepam for treatment of phobias.


Another amitriptyline side-effect?

Another amitriptyline side-effect?


Iron deficiency without anaemia.

Iron deficiency without anaemia.


Oral contraceptives and cell replication.


Corticosteroids in pregnancy.

Corticosteroids in pregnancy.


Oedema in pregnancy.

Oedema in pregnancy.


Gamma-radiation damage to Starr-Edwards valves.


Carbohydrate metabolism in the newborn.

Carbohydrate metabolism in the newborn.


Hypoxaemia in bronchial asthma.

Hypoxaemia in bronchial asthma.


Growth hormone in African pygmies.

Growth hormone in African pygmies.


Steroid therapy and hyperosmolar non-ketotic coma.


Viral diagnosis by immunofluorescence.

Viral diagnosis by immunofluorescence.


Hypocalcaemic fits in neonates.

Hypocalcaemic fits in neonates.


Treatment of Burkitt's lymphoma.

Treatment of Burkitt's lymphoma.


Gene amplification in the oocyte nucleus of mutant and wild-type Xenopus laevis.


Passive sensitization of Salmonella adelaide to the bactericidal action of antibody and complement.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1968.


Intensive care ward in a neurosurgical unit.


The presence of immunoglobulin in the bursa of Fabricius.


Differentiation of avian thrombocytes from leukocytes by use of Giemsa's stain.


Isolation and some properties of rabbit IgM immunoglobulin.


Studies on fluorescent cobrotoxin.

Studies on fluorescent cobrotoxin.


Multimolecular forms of profibrinolysin revealed by a zymogram technique.


Leukocyte alkaline phosphatase: a quantitative and qualitative study in normal and leukemic cells.


Some clinical features of hyper- and hypo-thyroidism in the elderly.


Value of cytotoxic drugs in malignant disease.


Contamination of eye drops used for vital staining. Bacteriological analyses of rose bengal-fluorescein, alcian blue and fluorescein-novesin, instilled from a needle-mounted tube.


Ultrastructure of mucous thread in inferior conjunctival fornix.


Fluorescent antibody studies of Vibrio fetus: staining characteristics in semen, preputial exudate, and pure culture.


Effect of ultraviolet irradiation on the acid-fastness of difficult to culture and unculturable mycobacteria.


An immunoglobulin abnormality in pulmonary emphysema.


The microscopy of "brown degeneration" in the adrenal gland of the mouse.


Polycyclic hydrocarbons in singed food in Iceland.


On the occurrence of two types of argyrophil cells in the pancreatic islets of the holocephalan fish, Hydrolagus colliei.


Ultrastructure of the sinus gland of the crayfish, Procambarus clarkii.


Thyroxine and triiodothyronine turnover in the chicken and the bobwhite and Japanese quail.


Effects of thyroxine analogs on isolated tadpole tail-tips.


Ontogenetic changes of lactate dehydrogenase isozymes in two species of Ambystoma.


Studies of Rorschach content: a review of research literaure. 3. Theoretical formulations.


Isolation of some alpha-1-globulins from rat serum.


The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town.


IgG cryoglobulinaemia Case report and immunological studies of a patient with recurrent ulcerative stomatitis and high content of cold precipitable immunoglobulin in serum.


Three M-components in serum from an apparently healthy person.


Glomerular localization of DNA and antibodies to nuclear constituents.


Serological diagnosis of primary biliary cirrhosis: a potential clue to pathogenesis.


The mechanisms involved in testicular degeneration in man. Advance of a theory of the pathogenesis in "idiopathic" hypospermatogenesis.


Influence of incubation temperature on the content of different corrinoids in the cells of Propionibacterium shermanii.


The juxtaglomerular apparatus in fetal and newborn mice.


The histochemistry of carbohydrate-rich substances in certain ungulate salivary glands.


Chromosomal changes associated with differentiation.


IgG associated with microsomes from autochthonous hepatomas and normal liver of rats.


Formal discussion: the role of transplantation in the experimental investigation of human leukemia and lymphoma.


Formal discussion: on the cellular origins and distinctive features of cultured cell lines derived from patients with leukemias and lymphomas.


Immunologic studies in American patients with Burkitt-like lymphoma.


Definition of an antigenic system associated with Burkitt's lymphoma.


The role of immunology in the treatment of leukemias and hematosarcomas.


Properties of Syrian hamster cells transformed in the presence of carcinogenic hydrocarbons.


Intraprostatic lymphatics.

Intraprostatic lymphatics.


The nature of human serum insulin-like activity (ILA)P Characterization of ILA in serum and serum fractions obtained by acid-ethanol extraction and adsorption chromatography. Studies were undertaken in an attempt to clarify the apparent heterogeneous nature of human serum insulin-like activity. Methods of preparative zone electrophoresis on Pevikon, acid-ethanol extraction of trichloroacetic acid serum protein precipitates, adsorption chromatography on DEAE-cellulose and Dowex 50, gel filtration chromatography, and insulin antiserum immunoreactivity were used. The results establish the presence of a substance in serum with in vitro biological properties similar to insuln but with different physicochemical properties. The major portion of serum ILA measured by bioassay techniques can be attributed to the effects of this substance. Whereas the in vitro biological effects of this substance on muscle and adipose cells were similar to those of crystalline insulin, the substance is distinguished from insulin by: (1) the failure of insulin antiserum to inhibit its in vitro biological effect; (2) a slower electrophoretic mobility (in the gamma-beta globulin zone); and (3) a larger molecular weight, between 40,000 and 50,000 in these studies. It is similar to insulin since both are soluble in acid-ethanol. The results further indicate that previously described insulin-like activity in gamma-beta globulin preparations, the major portion of total serum insulin activity described in acid-ethanol extracts of serum, "bound" insulin, "atypical" insulin, and antibody nonsuppressible insulin-like activity bioassayed in diluted serum are all one and the same substance.


Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise. Urine was collected from 6 healthy male adults at rest and from 20 male adults after a marathon race (25 miles). The concentrated urines were quantitatively analyzed, by single radial immunodiffusion, for their content in 12 different plasma proteins: tryptophan-rich prealbumin, albumin, alpha(1)-acid glycoprotein, alpha(1)-antitrypsin, ceruloplasmin, haptoglobin, Gc-globulin, transferrin, hemopexin, beta(2)-glycoprotein I, gammaA-globulin, and gammaG-globulin.Albumin, gammaA-globulin, and gammaG-globulin represent the major part of the plasma proteins detected in normal urine excreted by humans at rest (12, 0.5, and 2.5 mg respectively, out of a total excretion of 17.5 mg of plasma proteins per 24 hr). The other plasma proteins were excreted at a lower rate (< 0.4 mg/24 hr). The relative content of tryptophan-rich prealbumin, alpha(1)-antitrypsin, Gc-globulin, transferrin, and gammaG-globulin was lower in normal urine than in normal serum, whereas that of alpha(1)-acid glycoprotein, beta(2)-glycoprotein I, and gammaA-globulin was higher. The ratio of gammaG-globulin to gammaA-globulin was 4.9:1. When plotted on a logarithmic scale, no direct relationship between the molecular weight of a protein and the value of its renal clearance could be observed.Strenuous exercise increased (up to 50-fold) the excretion of plasma proteins which represent 82% of the total proteins found in urine, instead of 57% in urine collected from humans at rest. There was particularly a significant rise of tryptophan-rich albumin, albumin, alpha(1)-acid glycoprotein, transferrin, gammaA-globulin, and gammaG-globulin (0.26, 127, 11.8, 3.3, 1.2, and 2.0 mug respectively, out of a total excretion of 167 mug of plasma proteins per min). The ratio of gammaG-globulin to gammaA-globulin was 16:1. After exercise, the renal clearance of proteins increased from 2 to 40 times, but, as for the urine of normal subjects at rest, no direct relationship between molecular weight and renal clearance could be observed.


Interferon production and RNA inhibitors.


The effect of trimethaphan camphorsulfonate on the human digital circulation.


Immunosuppression in allogeneic murine tumour system. A model for the study of antilymphocyte serum.


Apparatus for recording electrocardiograms, incorporating automatic search and high-speed playback.


Bacteriology in the surgery.

Bacteriology in the surgery.


Blasts in lepromatous leprosy.

Blasts in lepromatous leprosy.


Antibodies to IgM in normal human sera.

Antibodies to IgM in normal human sera.


Mixed agglutination between established Burkitt cell lines and fresh biopsy specimens.


Staining of mast cell acid glycosaminoglycans in ultrathin sections by ruthenium red.


Juvenile bilateral carotid artery thrombosis.


An autopsy case of acute myelogenous leukemia associated with ascending transverse spinal syndrome and review of the literature.


Blood mucoids in juvenile rheumatoid arthritis.


Hypoplastic left ventricle syndrome. Analysis of thirty autopsy cases in infants with surgical considerations.


The IgA system. II. The clinical significance of IgA deficiency: studies in patients with agammaglobulinemia and ataxia-telangiectasia.


New York State action to combat air and water pollution.


The development and manufacture of control equipment. Organization of industrial programs.


Limit setting and psychological maturation.


The innervation of the mammalian lung. 3. Regression of the intrinsic nerves and of their afferent receptors following thoracic sympathectomy, cervical vagotomy or thoracic stripping of the vagus.


Antihaemophilic globulin (AHG) in multiple myeloma and macroglobulinaemia.


Effects of an anti-androgen, SH 714 (6-chlor-delta-6-1, 2-alpha-methylen-17-alpha-hydroxyprogesterone acetate, cyproterone acetate) on canine prostatic hyperplasia.


Studies on the development of the gonads in embryos of the domestic pig (Sus scrofa dom. L.). 3. An attempt at defining the nature of cells displaying PAS-positive granules in the differentiating ovary anlage.


Preservation of the iodine stain for the phosphorylase reaction.


Effect of whole x-irradiation of rats on net synthesis of albumin, fibrinogen, alpha-1-acid glycoprotein, and alpha-2-globulin (acute phase globulin) by the isolated, perfused rat liver.


A modification of the hemolytic plaque assay for use with protein antigens.


Gamma-G-antibody to human anti-hemophilic globulin (factor 8).


The inhibition by normal gamma-G-globulins of antibodies specific for individual gamma-G-myeloma proteins.


Rejection of lethal tumors after subcutaneous inoculation: a phenomenon of antigenic expression?


Surgical treatment of dextrocardia with inversion of ventricles and double-outlet right ventricle.


Surgical treatment of cardiac defects associated with variations in cardiac position.


Pesticide concentrations in fat.

Pesticide concentrations in fat.


Acetic acid in the treatment of superficial wounds infected by Pseudomonas aeruginosa.


Effect of abdominal operation upon protein excretion in man.


Left-ventricular endomyocardial fibrosis and mitral incompetance. A new syndrome.


Supply of human immunoglobulin in England and Wales for the prophylaxis of certain infectious diseases.


Progressive patient care. 2.

Progressive patient care. 2.


Evidence of a common antigenic specificity on heavy chains from human IgG, IgM and IgA.


Caseinolytic and fibrinolytic activities of human plasma in starch block electrophoresis.


The use of a ubiquinone-deficient mutant in the study of malate oxidation in Escherichia coli.


The inhibition of succinate oxidation in isolated mitochondria by uncouplers.


On the nature of electron and energy transport in mitochondria. II. Multiple activation of mitochondrial respiration.


Localization of fibrinogen in the tumor tissue.


A transplantable hyalinogenic tumor of the mouse.


DNA-RNA hybridization studies of myeloma tumors in mice.


A suggested mechanism of uncoupling of respiratory-chain phosphorylation.


Studies on cell-free synthesis of rat immunoglobulins, I. A cell-free system for protein synthesis prepared from lymph-node microsomal vesicles.


Laryngectomy.

Laryngectomy.


Surgical alleviation of coronary artery disease.


Confabulation following brain injury. Its analogues and sequelae.


Some aspects of psychotic behavior in young children.


The transport of beryllium in rat blood.


Infusion of isologous immune plasma in chronic lymphocytic leukemia.


Amyloidosis associated with cyclic neutropenia in the dog.


Coexistence of polycythemia vera and biclonal gammopathy (gamma-GK and gamma-AL) with two Bence Jones proteins (BJK and BJL).


An automatic add-subtract mode switch for use with response averagers.


Electromyographic observations in chronic lathyrism.


Tetrodotoxin analysis of direct cortical responses.


Interaction of direct cortical responses--a possible dendritic site of inhibition.


Re-analysis of the antidromic cortical response. I. Potentials evoked by stimulation of the isolated pyramidal tract.


Intracellular phenomena and spread of epileptic seizure discharges.


EEG and mental abilities.

EEG and mental abilities.


Habituation of evoked potentials in the rat under conditions of behavioral control.


The muscle silent period: variability in normal man.


Telemetered EEG from a football player in action.


Anticonvulsant properties of nitrazepam (mogadon).


Paroxysmal cerebral discharge associated with paroxysmal atrial tachycardia.


Some observations on bedside (portable). EEGs.


Behavior disorders of childhood and electroencephalogram.


Electrographic correlates of conative states.


A demonstration of the effect of eye position and accommodation on the occipital alpha rhythm.


The concept of attention and the EEG alpha-rhythm.


Visual evoked potentials to color light in normal controls.


EOG and EEG measurement while learning to position the eyes when the lids are open and closed.


The influence of paroxysmal spike and wave EEG activity on sensory evoked potentials in man.


Cholinergic induction of thalamo-cortical seizures in cats.


Alteration in photo-evoked response following x-irradiation of the monkey cerebral cortex.


Relation of brain injury to slow potential changes accompanying H-ion concentration changes in the blood.


Inhibitory effect of hippocampal seizures on unit responses evoked by fifth nerve stimulation in squirrel monkey.


Evidence for dual amygdalo-hypothalamic projection system.


Analysis of nigro-caudate relations.

Analysis of nigro-caudate relations.


Relationships of evoked surface and single unit activity in the cerebellum.


Quantitative analysis of horizontal eye movements.


Fainting (syncope), with particular reference to breath-holding spells in young children.


Electroencephalographic changes following head injuries.


EEG changes in recent post-partum hypopituitarism.


Epilepsy which ceased after pneumoencephalography (PEG) performed with air under pressure.


An electrodiagnostic study in arteriosclerotic peripheral vascular disease.


The mode of action of mineral-oil emulsion adjuvants on antibody production in mice.


Vibriocidal activity, immune globulin producing cells and immune globulin levels in Theropithecus gelada after administration of a vibrio cholerae antigen.


Pan- and auto-agglutination in albumin: a serological and immunochemical study of five cases.


Further studies of antigen stimulation of deoxyribonucleic acid synthesis in rabbit spleen cell cultures. I. The effects of centrifuged proteins.


Further studies of antigen stimulation of deoxyribonucleic acid synthesis in rabbit spleen cell cultures. II. The effects of specific antibody.


Distribution of alpha-chain subclasses in normal and pathological IgA-globulins.


Identical allotypic markers of heavy polypeptide chains present in different immunoglobulin classes.


Some considerations of the doctor-patient relationship in the practice of surgery.


On human symbiosis and the vicissitudes of individuation.


Ultrastructural localization of pemphigus autoantibodies.


Comparison of amino acid and alfalfa supplementation of purified diets ruminants.


Recent progress in surgery of the esophagus. II. Clinical entities.


Experimental coronary artery narrowing in swine. I. Morphologic and histochemical changes.


he effect of cations on the binding of 3,4-benzpyrene by plasma proteins.


Long acting thyroid stimulator of Graves's disease.


First aid for fractures. 3. Spine, ribs and clavicle.


Immunologic amnesia. Study of an 11-year-old girl with recurrent severe infections associated with dysgammaglobulinemia, lymphopenia and lymphocytotoxic antibody, resulting in loss of immunologic memory.


Prediction from the assessment of neuromotor and intellectual status in infancy.


The human cornea: a light and electron microscopic study of the normal cornea and its alterations in various dystrophies.


The differential staining of peritubular and intertubular matrices in human dentine.


Nursing aspects of fluid therapy in the postoperative patient.


An electron-microscopic study of zinc iodide-osmium impregnation of neurons. I. Staining of synaptic vesicles at cholinergic junctions.


Screening of antimycoplasma antibiotics.


Effect of antibiotics on the growth of various strains of Mycoplasma.


The mode of action of quinoxaline antibiotics. Interaction of quinomycin A with deoxyribonucleic acid.


Combined cytochemical and electron microscopic demonstration of beta-glucuronidase activity in rat liver with the use of a simultaneous coupling azo dye technique. Rat liver was fixed in formal-cacodylate-sucrose and frozen sections were incubated in a simultaneous-coupling medium containing naphthol AS-BI glucuronide as substrate and hexazonium pararosanilin as the diazo reagent. By light microscopy, the sections demonstrated beta-glucuronidase activity as red discrete granules in the pericanalicular cytoplasm and as a generalized cytoplasmic stain in the parenchymal cells. Brief treatment of sections in cold ethanol prior to incubation markedly enhanced the staining for the enzyme and made it possible to demonstrate sufficient amounts of the reaction product in sections embedded in epoxy resin following dehydration and propylene oxide treatment. Electron microscopy revealed that the reaction product was moderately electron opaque and deposited in greater amounts in the vacuolated dense bodies and occasionally in the dense bodies which did not show obvious vacuoles. In each dense body, the deposits occurred preferentially at the edge as well as in the area surrounding the vacuoles in the matrix. Control sections incubated in the presence of glucosaccharo-1:4-lactone were devoid of the reaction product. No deposits of the reaction product were found in the nucleus, mitochondria, or microbodies. The limitations of the present cytochemical technique for use in electron microscopy are briefly discussed.


Some observations on the demonstration of mucin in human tissue.


Fine structural alterations associated with venom action on squid giant nerve fibers. (1) Block of conduction and marked increase in permeability of the squid giant axon, when surrounded by adhering small nerve fibers, is caused by the venoms of cottonmouth, ringhals, and cobra snakes and by phospholipase A (PhA). This phenomenon is associated with a marked breakdown of the substructure of the Schwann sheath into masses of cytoplasmic globules. Low concentrations of these agents which render the axons sensitive to curare cause less marked changes in the structure of the sheath. (2) Rattlesnake venom, the direct lytic factor obtained from ringhals venom, and hyaluronidase caused few observable changes in structure, correlating with the inability of these agents to increase permeability. (3) Cottonmouth venom did not alter the structure of giant axons freed of all adhering small nerve fibers. This is in agreement with previous evidence that the venom effects are due to an action of lysophosphatides liberated as a result of PhA action. Cetyltrimethylammonium chloride, a cationic detergent, produces effects that resemble those of venom and PhA. (4) The results provide evidence that PhA is the component of the venoms that is responsible for their effects. It also appears that the Schwann cell and possibly the axonal membrane are the major permeability barriers in the squid giant axon.


A review of the modern concepts of immunology.


Passage of antibiotics through the digestive tract of normal and scouring calves and their effect upon the bacterial flora.


Autoradiography of water-diffusible substances in sections of whole baby rats.


Staining of oligodendroglia with silver ammino tungstate in unembedded and embedded material.


Qualitative analysis by thin-layer chromatography of some common dyes used in biological staining.


Uses of a polyethylene foam (Ethafoam) in cryostat operation.


A stain for differentiating two types of acidophil cells in the rat pituitary.


Optimum timing of Leifson's flagella stain by interval variations on one slide.


Differential staining of cartilage and bone in the intact chick embryonic skeleton in vitro.


Staining whole mounts of an insect (Tribolium confusum) reproductive system for succinic dehydrogenase and nonspecific esterase.


Characteristics for two classes of embryonic cells in oncospheres of Hymenolepsis diminuta stained for cytoplasmic substances.


A rotation experience helps educate nurses.


Obstructive lymphopathy.

Obstructive lymphopathy.


Preparation of I-131-gamma-globulin aggregates.


Embryonal serum alpha-globulin in cancer patients: diagnostic value.


Construction of film-loop programs: a new twist.


The aetiology of gallstones.

The aetiology of gallstones.


Hallucinations, alcohol withdrawal, and thiamine deficiency.


Detection of antinuclear factor activity in rheumatic diseases.


Medical brain drain perspectives.

Medical brain drain perspectives.


Is verapamil a beta-blocker?

Is verapamil a beta-blocker?


Frederick Lucien Golla.

Frederick Lucien Golla.


James Dixon Boyd.

James Dixon Boyd.


Normal immune responses of bursaless chickens to a secondary antigenic stimulus.


Effect of F(ab')2 from rabbit anti-mouse lymphocyte IgG on the graft versus host reaction in F1 hybrid mice.


In vivo and in vitro effect of anti-lymphocytic IgG on sensitized spleen cells.


Gamma globulin production and antibody synthesis in chickens bursectomized as embryos.


Effects of cercarial extracts of Schistosoma mansoni on HeLa cells.


Transport piece in the urines of premature infants.


A histological study of the mesencephalic nucleus of the fifth cranial nerve.


The neuromuscular spindles in the adult chicken. I. Morphology.


The corpus callosum of the dog.

The corpus callosum of the dog.


A new tissue culture method for studies on antibody synthesis in vitro by lymphoid cell suspensions.


Ultracentrifugation using acrylamide gel.


Therapeutic incompatibilities.

Therapeutic incompatibilities.


Comparative light and electron microscopic observations of the cytoplasmic matrix in renal carcinomas.


Professor Dr. Karol Zodrow July 13, 1916--October 12, 1966.


Immunochemical investigations of aqueous and phenol extracts from S and R forms of Salmonella typhimurium.


Agar gel electrophoresis for determination of components of culture filtrate of BCG and virulent tubercle bacilli. I. The application of histochemical staining methods for detecting of proteins, polysaccharides, nucleic acids and lipids in culture filtrates of BCG and tubercle bacilli strains.


Serum proteins, glycoproteins and antibodies in guinea pigs infected with BCG and virulent Mycobacterium tuberculosis.


Effect of BCG immunization on succinic and lactic dehydrogenase activity of guinea pig liver in experimental tuberculosis.


Effect of infection with Mycobacterium tuberculosis and BCG on the lactic dehydrogenase and succinic dehydrogenase activity of guinea pig liver.


Studies on mycobacterial sensitizing fractions. I. Preparation of PPD-S tuberculin for diagnostic use.


Immunoglobulin levels in serum of normal infants and preschool children as determined by immunochemical analysis.


Electron microscopic studies of fibrinoid.


The size of Dientamoeba fragilis in culture.


Morphological changes in lasmodium vivax in patients under treatment with chloroquine.


Symposium on equine bone and joint diseases. Osteolysis in pathological material.


Histamine release following intravenous injection of d-tubocurarine.


Lower brain-stem EEG synchronizing mechanisms in the rabbit.


Variability of the EEG in schizophrenia: quantitative analysis with a modulus voltage integrator.


Effects of vestibular stimulation during sleep.


Effects of experimental intracranial hypertension on cerebral blood flow, EEG and blood-brain barrier.


Epilepsia partialis continua (EPC) and petit mal attacks observed in the same patient.


Accidental convulsions in recurrent post-traumatic meningitis.


The effects of hypnotic suggestion on the acoustic evoked potential.


A new rapid method for genetic typing of human immunoglobulins.


Cryotherapy for inoperable rectal cancer.


Urinary Fc and F'c fragments.

Urinary Fc and F'c fragments.


Neutralization of sensitized lactic dehydrogenase virus by anti-gammglobulin.


Studies of thoracic duct lymphocytes of mice. I. Immunoglobulin synthesis in vitro.


Antibody nature of an AHG (factor 8) inhibitor.


Pyoderma gangrenosum treated with 6-mercaptopurine and followed by acute leukemia.


Subclinical vitamin-D deficiency following gastric surgery. Histological evidence in bone.


Investigations into the epidemiology of leishmaniasis. Unsuccessful search for the reservoir host of kala-azar in Baghdad.


Diagnosis of Conn's and other adrenal tumours by left adrenal phlebography.


Cystic fibrosis of the pancreas. A generalised disturbance of water and electrolyte movement in exocrine tissues.


Psychiatric dinosaurs.

Psychiatric dinosaurs.


Obliteration of spinal-cord arteriovenous malformation by percutaneous embolisation.


Estimating energy expenditure.

Estimating energy expenditure.


Mortality and infection in extensively burned patients treated with silver-nitrate compresses.


Local chemoprophylaxis for burns with gentamicin and other agents.


Estimation of endogenous renin in human blood.


Clostridium welchii resistance to tetracycline.


Poliomyelitis associated with type-2 poliovirus vaccine strain. Possible transmission from an immunised child to a non-immunised child.


Response of sweat glands to pilocarpine in the Bantu of Uganda.


Reversible renal failure in idiopathic nephrotic syndrome with minimal glomerular changes.


Measurement of splenic red-blood-cell mass with radioactive carbon monoxide.


Pathogenesis of hyperthyroidism. Dual role of iodine in thyroid function.


Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan.


The silver swaddler. Device for preventing hypothermia in the newborn.


Gonorrhoea.

Gonorrhoea.


Psychiatric care of the adolescent.

Psychiatric care of the adolescent.


Therapeutic abortion.

Therapeutic abortion.


Clioquinol and other halogenated hydroxyquinolines.


By any name.

By any name.


Motivation of the physically disabled.

Motivation of the physically disabled.


Menstrual rhythms.

Menstrual rhythms.


The special hospitals.

The special hospitals.


Early discharge after hernia repair.

Early discharge after hernia repair.


Poisoning on the farm. Report of a case of organophosphorus poisoning.


Cerebral effects of beta-adrenergic blockade.


Hypocalcaemic fits in neonates.

Hypocalcaemic fits in neonates.


Hypocalcemic fits in neonates.

Hypocalcemic fits in neonates.


Haemorrhage and clotting state in the newborn.


World-wide viruses.

World-wide viruses.


Effects of legalising abortions.

Effects of legalising abortions.


Oral contraceptives and cell replication.


Epilepsy and schizophrenia.

Epilepsy and schizophrenia.


Bleeding-time after aspirin ingestion.

Bleeding-time after aspirin ingestion.


Cold water for burns and scalds.

Cold water for burns and scalds.


Lyon hypothesis and x-linked disease.

Lyon hypothesis and x-linked disease.


Marrow aplasia and methyldopa.

Marrow aplasia and methyldopa.


Cyclic regimen for childhood leukaemia.

Cyclic regimen for childhood leukaemia.


Modified resin for hyperkalaemia.

Modified resin for hyperkalaemia.


Effects of synthetic human corticotrophin.


Nutrition at great heights.

Nutrition at great heights.


Histologic and teased-fiber measurements of sural nerve in disorders of lower motor and primary sensory neurons.


micro-teaching in preparing faculty.

micro-teaching in preparing faculty.


An audiotutorial approach to learning.

An audiotutorial approach to learning.


Sephadex gel filtration method for determination of protein-bound 131-I-triiodothyronine as an in vitro test of the thyroid function.


Studies of the stainability of necrotic striated muscle and muocardium.


Producing 35 mm. black and white slides from illustrations and cine film.


The legacy of academician Burian.

The legacy of academician Burian.


Plastic surgery in research on the pathological process in the maxillo-facial sphere.


Proposed classification of rare congenital cleft malformations in the face.


The management of the bilateral cleft lip deformity. A progress report.


Clinical observation of the spontaneous regeneration of the mandible.


Eleven years impression of surgery of cleft palate.


Congenitally short urethra.

Congenitally short urethra.


Aplasia of the vagina. Reconstruction by a free skin graft.


The longterm result of operations for aplasia of the vagina.


The sexuological aspects of hypospadias.


The estimation of galactose, mannose and fucose in glycoproteins by radioisotope dilution. 1. The principle of radioisotope dilution, as used previously for the estimation of mannose in egg albumin, was applied on a semi-micro scale to the estimation of fucose, mannose and galactose in some glycoproteins. The sugars were separated by partition chromatography on columns of Celite 545. 2. The release of mannose from egg albumin in 2n-hydrochloric acid at 100 degrees after various times was determined by the radioisotope-dilution method and found to have a half-time of 7min. 3. The destruction of mannose in 2n-hydrochloric acid after 3hr. at 100 degrees was found to be small if air was excluded. The destruction was slightly increased by the presence of lysozyme containing tryptophan in an amount equimolar with the mannose. The same amount of free tryptophan caused considerable loss of mannose. 4. Analytical values are reported for the non-amino sugar contents of egg albumin, rabbit gamma-globulin and some samples of blood-group-specific substances. The values found were similar to the most reliable estimates published previously.


Visual recognition, developmental lag, and strephosymbolia in reading retardation.


Structural changes in mitochondria induced by uncoupling reagents. The response to proteolytic enzymes. Interaction of uncoupling reagents with bovine serum albumin markedly inhibited its hydrolysis by proteolytic enzymes. The inhibition presumably is due to conformational transitions in the protein substrate induced by the binding of the ligand-uncoupling reagents. The proteolysis of casein, a protein that does not bind these reagents, was not affected, indicating that the proteinases themselves were not inactivated. In contrast, interaction of uncoupling reagents with freshly isolated rat liver mitochondria enhanced their susceptibility to proteolytic enzymes. This was shown by an increase in the release of ninhydrin-reacting material, by an increase in free acid groups and by a decrease in the turbidity of the mitochondrial suspensions. These effects, although opposite in direction to those obtained with albumin, are also presumed to indicate structural changes in the mitochondrial proteins and a disorganization of the protein-phospholipid complex. It is suggested that such structural alterations are expressed functionally as the uncoupling of oxidative phosphorylation.


The histochemical demonstration of protein in epithelial mucins.


Some observations on the electron microscopy of lipids.


Combined protein and DNA measurements in plant cells using the dinitrofluorobenzene and feulgen techniques.


Research on reading aids for the blind--a dilemma.


A new, simple route to tetracyclic intermediates for the synthesis of diterpenoid alkaloids.


Synthesis in the series of diterpene alkaloids 8. A stereospecific synthesis of pentacyclic intermediates with a bridge in ring B.


Ultrastructural changes in rat mast cells during anaphylactic histamine release.


Characteristics of protein synthesis in vitro by lymphocytes from human peripheral blood.


Apical organization in the somatic hyphae of fungi.


The starch-gel electrophoresis of glucose-6-phosphate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase of Streptococcus faecalis, S. faecium and S. durans.


Fine structural basis of hemoglobin filtration by glomerular capillaries.


Roles of intellectual abilities in the learning of concepts.


N-terminal sequences of heavy and light chains of leopard shark immunoglobulins: evolutionary implications.


Immunogenic response of the venoms of fer-de-lance, Bothrops atrox asper, and la cascabella, Crotalus durissus durissus, following photooxidative detoxification.


Immunization studies with Naja naja venom detoxified by photooxidation.


Effect of the route of administration on the neutralizing potency of antivenins.


Thyroid function tests.

Thyroid function tests.


Amyloid in corneal dystrophies. Differentiation of lattice from granular and macular dystrophies.


Comments on findings of elevated protein-bound iodine in superior limbic keratoconjunctivitis: I.


Comments on superior limbic filamentous keratitis: II.


Ring fibers in human spleens.

Ring fibers in human spleens.


Glomerular lesions in NZB/NZW mice. Electron microscopic study of development.


Identification of immunoglobulin G in the vitreous of rabbits.


Fluorescein staining in primary pigmentary degeneration of the Retina. A histological study in rats.


Precipitins to pneumococcal C-substance polysaccharide in the serum of patients with chronic bronchial disorders.


Interactions of the complement system with native and chemically modified endotoxins. Endotoxic lipopolysaccharides (LPS) isolated from Serratia marcescens, Veillonella alcalescens, and Salmonella typhosa were potent in their ability to induce fixation of complement (C') in normal guinea pig, rabbit, mouse, and human serum. The C'-fixing ability of LPS was pronounced even when assays were performed in undiluted serum, and was lost after each of four chemical modifications which resulted in loss of biological toxicities. The detoxification procedures had in common the cleavage of ester-bound, long-chain carboxylic acids. The ability of biologically active LPS to fix C' in normal guinea pig serum was reflected chiefly in dramatic uptake of classical C'3 (C'3t); fixation of C'1, C'4, and C'2 was virtually undetectable. Hence, it was the capacity for fixation of C'3t which was lost most overtly during detoxification. Addition of immune serum to the assay mixtures resulted in detectable fixation of C'1 and C'4. Biologically active LPS also fixed more of these components than did detoxified LPS. Immune serum restored the ability of detoxified LPS to fix C'3t, but whether this is by the original pathway is not yet clear. We concluded that the loss of certain biological activities and the loss of ability to fix C'3t in normal serum after LPS detoxification involved loss or rearrangement of substrates on LPS which either initiated or supported, or both, its interaction with the complement system. It was apparent that the ability to fix C' can serve as a valuable in vitro indicator of the integrity of the toxic conformation of biologically active LPS membrane fragments. These experiments supported the hypothesis that certain of the biological activities induced by endotoxins are mediated via the complement system.


Psychiatric disturbance leading to potassium depletion, sodium depletion, raised plasma-renin concentration, and secondary hyperaldosteronism.


Why replace a missing tooth.

Why replace a missing tooth.


Bacterial precipitins in serum of patients with cystic fibrosis.


Fluorescent antibodies in diagnosis of infections.


Hypermagnesaemia and platelet function in uraemic bleeding.


Partial E-18 long-arm deletion.

Partial E-18 long-arm deletion.


Glucagon in sulphonylurea hypoglycaemia?


Immunoglobulin synthesis in long term cultures of lymph nodes from Hodgkin's disease.


Districts: Pennsylvania Dental Association.


Bubber behind bars.

Bubber behind bars.


Alkaline solvent systems for thin-layer chromatography of bile acids. Thin-layer chromatographic separation of the common bile acids and their taurine and glycine conjugates in chloroform-methanol-ammonia is reported. An alkaline system offers advantages for the separation and nondestructive staining of bile acid conjugates.


Caring for a patient having open-heart surgery.


Nursing care of the gallbladder patient.


Preventive dentistry--a challenge.

Preventive dentistry--a challenge.


Dental research at Philadelphia General Hospital.


Middle of the road.

Middle of the road.


Symposium on research and utilization of educational media for teaching the deaf. Media personnel in a school for the deaf.


Corneal endothelial changes during the hypersensitivity reaction.


Corneal epithelium changes in rabbit congenital glaucoma.


Prognostic factors in malignant tumors of the lung: an analysis of 582 cases.


The treatment of transposition of the great vessels.


As I see it: three R's of nursing.

As I see it: three R's of nursing.


President's address.

President's address.


Greetings from the National Association of Theatre Nurses.


Cryotherapy for malignant tumors. Immunologic response.


Outlook in Rh-haemolytic disease.

Outlook in Rh-haemolytic disease.


The psychological costs of quality and equality in education.


Albumin exchange between plasma and ascitic fluid.


Studies on DNA replication during synchronized vegetative growth and gametic differentiation in Chlamydomonas reinhardtii.


Localization of iron and leghaemoglobin in the legume root nodule by electron microscope autoradiography.


Respiration of rat peritoneal mast cells during histamine release induced by antigen-antibody reaction.


Studies on the nuclei of cultured human leukemic lymphoblasts (CCRF-CEM cells): method of isolation.


Cytochemical studies on the concurrent synthesis of DNA and histone in primary spermatocytes of Urechis caupo.


Polyneuritis cranialis associated with industrial trichloroethylene poisoning.


A new method for the cytological examination of the cerebrospinal fluid.


Microgliomatosis.

Microgliomatosis.


Bibliographies on diseases of medical progress. Adverse reactions to heparin and heparinoids.


The effect of an intra-uterine plastic device on the mast cell count in the rat uterus.


Effect of cyanide intoxication on the metachromatic material found in the central nervous system.


Pharmacology and toxicology of a defibrinating substance from Malayan pit viper venom.


Therapeutic defibrination in the treatment of thrombotic disease.


Anticoagulant therapy with a purified fraction of Malayan pit viper venom.


Complement deficiency and chromosomalbreaks in a case of Swiss-type agammaglobulinaemia.


Host temperature and control of 24-hour and 48-hour cycles in malaria parasites.


Rapid diagnosis of influenza.

Rapid diagnosis of influenza.


Low intracardiac potentials in myocardial infarction as a cause of failure of inhibition of demand pacemakers.


Severe head injuries.

Severe head injuries.


A new approach to anticoagulant therapy.


Coxsackie-virus encephalitis.

Coxsackie-virus encephalitis.


Arts v. science.

Arts v. science.


Where to nurse the elderly.

Where to nurse the elderly.


Emergencies in dental practice.

Emergencies in dental practice.


Family planning in medical education.

Family planning in medical education.


Holography.

Holography.


Independence in maintenance haemodialysis.


Paralysis in echovirus-3 infection.

Paralysis in echovirus-3 infection.


Effect of 32-p on leucocyte cultures.

Effect of 32-p on leucocyte cultures.


Platelet behaviour in multiple sclerosis.


Pyruvate kinase in human erythrocytes.

Pyruvate kinase in human erythrocytes.


Dysautonomia and aminoaciduria.

Dysautonomia and aminoaciduria.


Jujube in common bile duct.

Jujube in common bile duct.


Preventing depression with tryptophan.

Preventing depression with tryptophan.


Uric acid in bone-marrow.

Uric acid in bone-marrow.


Hypotension after oral propranolol.

Hypotension after oral propranolol.


Recurrent monocular blindness.

Recurrent monocular blindness.


Infection by anaesthetic apparatus.

Infection by anaesthetic apparatus.


Osteoporosis: disease or senescence?

Osteoporosis: disease or senescence?


Steroid excretion in aetiocholanolone fever.


Inheritance of calcium renal stones.

Inheritance of calcium renal stones.


Cri-du-chat with chromosomal mosaicism.

Cri-du-chat with chromosomal mosaicism.


Theatre nurse training.

Theatre nurse training.


Multiple myeloma. I. A review of the problems of protein structure.


Premature beats and acute myocardial infarction.


Family planning.

Family planning.


Perception of the speech code.

Perception of the speech code.


The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo.


Basic structure of group A arbovirus strains Middelburg, Sindbis, and Semliki Forest examined by negative staining.


Latent renal tubular acidosis in Sjøgren's syndrome.


Retinal atrophy in osteopetrosis.

Retinal atrophy in osteopetrosis.


Tazettine chemistry. X. The structure of products obtained from O-methyltazettine methine methosalts under the Hofmann elimination conditions.


Transposition of the great arteries: clinical and physiological observations on 74 patients treated by palliative surgery.


Diphenylhydantoin prevention of arrhythmias in the digitalis-sensitized dog after direct-current cardioversion.


Bradykinin and its allies.

Bradykinin and its allies.


Chemical and biological applications of Mössbauer spectroscopy.


Studies on passive haemolysis mediated by antiserum globulin antibodies.


Immunogenic potency of human gamma-globulin in mice.


Potentiation of lymph node antibody synthesis by normal thymus in vitro.


A new class of immunoglobulin in human serum.


Haemorrhagic reactions elicited at sites of passive cutaneous anaphylaxis by the intravenous injection of aggregated gamma-globulin.


Steroid-protein interactions. XVI. Isolation and characterization of the corticosteroid-binding globulin of the rabbit.


Ultrastructure of the tegument of adult Schistosoma mansoni.


Plasmodium lophurae infections and related serum protein changes in 2-week-old normal and hormonally bursectomized chickens.


Senile dementia.

Senile dementia.


An interdisciplinary approach to health education: the use of new research data.


The localization of tetracycline microfluorescence in tumors of the urinary tract.


Long-term follow-up of bacteriuria in pregnancy.


Adrenaline production by an intrathoracic phaeochromocytoma.


Transplacental haemorrhage after external cephalic version.


Karyotyping clonal evolution in a cystic adenoma of the ovary.


A gastric factor promoting iron absorption.


Pregnancy in a patient with a mitral-valve prosthesis.


Bagassosis.

Bagassosis.


Suberosis. Respiratory disease in cork workers.


Evidence for the existence of a lymphoid stem cell.


A "germfree" human isolator.

A "germfree" human isolator.


Revolting students.

Revolting students.


After Bikini.

After Bikini.


Aetiological factors in intestinal cancers.


Means of population control.

Means of population control.


Protein malnutrition after partial gastrectomy.


A new long-acting local analgesic.

A new long-acting local analgesic.


The ridge in endomyocardial fibrosis.

The ridge in endomyocardial fibrosis.


Training doctors in clinical biochemistry. A scandinavian comparison.


Bacteriological impurity of dairy-cream samples in London.


Fasten seat-belts.

Fasten seat-belts.


Pethidine in acute myocardial infarction.


Iron deficiency without anemia.

Iron deficiency without anemia.


Pancreozymin and serum-insulin levels.

Pancreozymin and serum-insulin levels.


Striated muscle in human thymus.

Striated muscle in human thymus.


Is lysergide a teratogen?

Is lysergide a teratogen?


Measurement of blood-glucose levels.

Measurement of blood-glucose levels.


Epileptic fits and amitriptyline.

Epileptic fits and amitriptyline.


Incidence of Klinefelter's syndrome and seasonal variation.


Klebsiellae in chronic respiratory disease.


Platelet function.

Platelet function.


Severe head injuries.

Severe head injuries.


Autoantibodies and methyldopa.

Autoantibodies and methyldopa.


Amenorrhoea after oral contraceptives.

Amenorrhoea after oral contraceptives.


Hypocalcaemie fits in neonates.

Hypocalcaemie fits in neonates.


Hypocalcaemic fits in neonates.

Hypocalcaemic fits in neonates.


Analgesic nephropathy.

Analgesic nephropathy.


XYY and intelligence.

XYY and intelligence.


Vitamin D, cholesterol, and calcium.

Vitamin D, cholesterol, and calcium.


A sign of gut perforation.

A sign of gut perforation.


The preconceptional menstrual period.

The preconceptional menstrual period.


Henry St. Clair Colson.

Henry St. Clair Colson.


William Allin Mill.

William Allin Mill.


Adjuvanticity of vitamin A.

Adjuvanticity of vitamin A.


Possible formation of an azulene-type radical obtained on heating 3,4-benzpyrene.


DNA synthesis in the development of antibody-forming cells during the early stages of the immune response.


Purification of antilymphocytic antibody.


Clinical evaluation and radiotherapeutic management of Hodgkin's disease and the malignant lymphomas.


Progress toward abatement of air pollution.


Concanavalin A in vivo: induction of hemorrhagic skin lesions (Arthus-like reactions) in mice. Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble (a2)- macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.


Thioflavine-T reactivity in calcifying epithelioma of Malherbe.


Histological and biochemical considerations in chemotherapy of tumours of the head and neck.


Demonstration of human reagin using monkey tissues. VI. Pharmacologic studies of in vitro passive sensitization of monkey ileum with sera from atopic patients.


Immunotherapy in ragweed hay fever.

Immunotherapy in ragweed hay fever.


Further ultrastructural observations on polysaccharide localization in plant cells.


The distribution of the protein-polysaccharide complex in the nucleus pulposus matrix in young rabbits.


Electron microscopy of keratin layer stripped human epidermis.


Studies on the in vitro behavior of agammaglobulinemic lymphocytes. Circulating lymphocytes from patients with congenital X-linked agammaglobulinemia, sporadic congenital agammaglobulinemia, and acquired agammaglobulinemia have been cultured in vitro. They have been shown to proliferate in a normal manner under stimulus of phytohemagglutinin and antigens to which the patient was sensitized. Agammaglobulinemic cells have been shown to synthesize protein at a rate similar to that of normal cells, and the character of the extracellular protein produced is also similar. Agammaglobulinemic lymphocytes have been found to produce a small quantity of immunoglobulin G, similar to that found in normal cell cultures. The quantity of immunoglobulin produced may be increased by exposure of the cells to phytohemagglutinin. From these data, it appears that the basic lesion responsible for agammaglobulinemia is not a deficiency in lymphocyte-mediated antigen recognition or cellular proliferation. It would also appear that the basic deficiency in these disorders does not involve the structural or regulatory genes necessary for the synthesis of immunoglobulins. By exclusion, the pathogenesis of the deficiency would appear to involve cells other than circulating lymphocytes.


Membrane pores and herpesvirus-type particles in negatively stained whole cells.


A simple and reliable test for sickling.


Aseptic methods in the operating suite.

Aseptic methods in the operating suite.


Relation between serum-free-fatty acids and arrhythmias and death after acute myocardial infarction.


Pulmonary oedema in bacterial shock.

Pulmonary oedema in bacterial shock.


Bone disease and calcium absorption in primary biliary cirrhosis with special reference to vitamin-D therapy.


Histochompatibility antigens on the HL-A locus in generalised gestational choriocarcinoma. A family study.


Assay of calcitonin in human plasma.

Assay of calcitonin in human plasma.


A sleep regimen for acute myocardial infarction.


An electric pessary for stress incontinence.


An extractor for the relief of obstructed air passages.


Reducing strangulated haemorrhoids with ethyl chloride.


Aetiology of complete heart-block.

Aetiology of complete heart-block.


Detection of urinary infection.

Detection of urinary infection.


Changing requirements in the treatment of diabetes.


Prognosis after rupture of anterior cerebral aneurysm.


Chloroquine in pulmonary sarcoidosis.

Chloroquine in pulmonary sarcoidosis.


A waterborne outbreak of gastroenteritis in adults associated with Escherichia coli.


The stiff aching back. The differential diagnosis of ankylosing spondylitis.


Hospital medical-staff structure.

Hospital medical-staff structure.


Height and weight of British men.

Height and weight of British men.


To be taken as directed.

To be taken as directed.


Hypomagnesaemia in nephrosis.

Hypomagnesaemia in nephrosis.


Measurement of blood-glucose levels.

Measurement of blood-glucose levels.


Tolbutamide and propranolol.

Tolbutamide and propranolol.


Treatment of hypercalcaemia.

Treatment of hypercalcaemia.


Oral-contraceptive opposition to hypocholesterolaemic action of clofibrate.


Blue light for jaundice in infants.

Blue light for jaundice in infants.


Mortality trends of renal diseases.

Mortality trends of renal diseases.


Audible Parkinsonian tremor.

Audible Parkinsonian tremor.


Cardiac-valve surgery in factor-VII deficiency.


Erythrocyte G.-6-P.D. and renal stasis.

Erythrocyte G.-6-P.D. and renal stasis.


A new type of pyruvate-kinase deficiency of human erythrocytes.


Antibody and tuberculous lesions.

Antibody and tuberculous lesions.


Estimating energy expenditure.

Estimating energy expenditure.


Aspirin adsorption with activated charcoal.


Uric acid in bone-marrow.

Uric acid in bone-marrow.


Oral contraceptives and serum-cholesterol.


Methylmalonic-acidaemia-hyperglycinaemia.


Amenorrhoea after oral contraceptives.

Amenorrhoea after oral contraceptives.


Asymptomatic hyperparathyroidism 30 years after parathyroidectomy.


Hypertension in two young sisters.

Hypertension in two young sisters.


Control of malaria cycle.

Control of malaria cycle.


Acute renal failure in diabetic acidosis.


Physiological inhibition of factor 8.

Physiological inhibition of factor 8.


Placental haemorrhage after version.

Placental haemorrhage after version.


Immunoglobulin synthesis in subacute sclerosing panencephalitis during x-irradiation of the brain.


Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy.


Experiences with perineal urethroplasty for stricture.


Gm factors in non-human primates.

Gm factors in non-human primates.


Effect of graded doses of carbimazole and propylthiouracil on the synthesis of the thyroid hormones.


Spectrophotometric determination of microgram quantities of protein without nucleic acid interference.


Treatment of thyroid crisis by beta-adrenergic blockade.


Separation of ribonucleic acids by polyacrylamide gel electrophoresis.


The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent.


Urinary tract complications of anticoagulation therapy; "pseudotumour" of the kidney.


Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical charaterization. A fragment termed fragment Fc' and a related fragment termed fragment pFc' produced by the actions of papain and pepsin respectively on human immunoglobulin G have been isolated and characterized. Amino acid analyses and experiments utilizing cyanogen bromide to cleave the methionyl bonds of the Fc' and pFc' fragments make it possible to locate both fragments within the known chain structure of the immunoglobulin G molecule. The pFc' fragment is probably a non-covalently linked dimer situated at the C-terminal end of the molecule, containing about 232 amino acid residues and having a molecular weight of 26000. The Fc' fragment is a similar dimer of about 182 residues extending from near residue 14 to near residue 105 (numbered from the C-terminal end) of the gamma-chain and has a molecular weight of 21000.


A simple plate test for the determination of protocatechuic acid utilization by soil bacteria.


Ultrastructural changes in embryonic mouse neural tube cells after urethane exposure.


Sex education as community education.

Sex education as community education.


Hepatorenal lesions in rats fed a low lipotrope diet and exposed to aflatoxin.


Familial occurrence of thyroiditis in purebred beagles.


A study of the possible correlation of euglobulin lysis time and dilute blood clot lysis time in the determination of fibrinolytic activity.


More chest roentgen signs and how to teach them. Annual Oration in memory of L. Henry Garland, M.D., 1903-1966.


Miniature teaching exhibit.

Miniature teaching exhibit.


Organ antibodies after local irradiation.


Carbon monoxide and air pollution from automobile emissions in New York City. Local business-day traffic determines the diurnal carbon monoxide concentrations at individual sites in Manhattan. Concentrations during the day can be predicted from readings taken in early morning.


Qualitative changes in immunoglobulin G in multiple sclerosis-cerebrospinal fluid.


Heredopathia atactica polyneuritiformis, biochemical defect and dietary treatment.


Paper electrophoretic fractionation and chemical determination of horse serum proteins and lipoproteins.


A lipid mobilizing substance from the calf mid-brain.


A clinico-immunological study of serum and synovial fluid antinuclear factors in rheumatoid arthritis and other arthritides.


Antibodies to salivary duct cells, and other autoantibodies, in patients with Sjögren's syndrome and other idiopathic autoimmune diseases.


Antibody deficiency syndrome: a case with normal immunoglobulin levels.


An approach to the study of soluble antigen-antibody complexes in clinical disease.


Effect of ageing of serum on consumption of antibody by beta-1C-globulin determinants; evidence for circulating breakdown products in glomerulonephritis.


Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults.


Immunological features of idiopathic Addison's disease: characterization of the adrenocortical antigens.


Antitoxic and antiviral antibodies in Cohn fractions of human plasma.


Amino acid sequence around disulfide bridges of pit immunoglobulin lambda-chains.


Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow.


The prenatal calcification of the first primary molar.


Investigation of proteinuria in pregnancy by immuno-electrophoresis.


Heterologous carriers in the anamnestic antihapten response. Anamnestic antihapten responses were obtained to trinitrophenyl (TNP) when rabbits sensitized to trinitrophenyl-hemocyanin (TNP-KLH) were challenged with TNP-heterologous protein conjugates. Hapten-heterologous carrier conjugates elicited antihapten titers similar in magnitude to those elicited by the homologous carrier conjugate. Hapten-heterologous carrier recall of antihapten was successful as early as 37 days and as late as 11 months after sensitization. There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier. The results are discussed in terms of immunogenicity of sensitization, suppressive effects of persisting postsensitization antibody, and submolecular haptenic environment as factors possibly affecting the heterologous recall process.


Experimental chronic glomerulitis.

Experimental chronic glomerulitis. Three of 16 rabbits injected (intravenously) daily with crystalline bovine serum albumin (BSA) for periods in excess of 10 wk developed chronic glomerulonephritis. In vivo, animals with chronic proteinuria formed variable quantities of soluble complex after injection of antigen while animals without proteinuria exhibited rapid removal of the injected BSA. In vitro studies demonstrated that a major part of the antibodies produced by rabbits with chronic nephritis lacked precipitating properties. Interpretations of these observations were presented in the discussion. It is suggested that, in addition to quantity, quality of antibody plays an important role in the development of chronic serum sickness. Complexes formed with nonprecipitating antibody, which are less rapidly removed from circulation, would have a greater opportunity to deposit in glomeruli and induce inflammation.


Estimation of duration of gestation by amniotic fluid cytology.


Screening blood donors for hepatitis virus.


Effects of early hypophysectomy on the development of the ossicular chain of rats.


Chronic intravascular coagulation syndrome.


Anaphylactoid edema: 1937-1967.

Anaphylactoid edema: 1937-1967.


Studies on the innervation of taste buds.


A comparison between the fibres of the periodontal membrane and the fibres of the annular ligament in the oval window.


Fluorescent microscopy in nasal cytology.


Proteins of middle ear secretion in serous ottitis. An electrophoretic and immunoelectrophoretic study.


Cellular pattern and nerve supply of the vestibular sensory epithelia.


Synthesis and cytopathogenesis of African swine fever virus in procine cell cultures.


Changes in phenoxazinone synthetase activity during the growth cycle of Streptomyces antibioticus.


Influence of actinomycin, cycloheximide, ethionine, and 5-fluorouracil on glycogen synthesis in the rat uterus.


Common peptides from the N-terminal half of heavy chain of immunoglobulin G from normal rabbit serum and a specific antibody. Fragment C-1, the N-terminal half of the heavy chain of rabbit immunoglobulin G, was prepared by cyanogen bromide cleavage from the heavy chain of immunoglobulin G obtained both from the pooled serum of normal rabbits and from specific anti-dinitrophenyl antibody. Tryptic digestion of fragment C-1 after the lysine residues had been allowed to react with S-ethyl trifluorothioacetate led to the isolation of six peptides from inert immunoglobulin G and specific antibody that appear to account for most of this section of the heavy chain. This approach should make possible comparative sequence studies of the Fd section of the heavy chain from different allotypes and from specific antibodies.


The partial sequence of two large peptides from the N-terminal half of heavy chains from normal rabbit immunoglobulin G. The partial amino acid sequence of two large peptides is described. These were prepared from the N-terminal half of the heavy chain of immunoglobulin G from pooled normal rabbit serum by tryptic digestion after the in-amino groups of the lysine residues had been blocked with S-ethyl trifluorothioacetate. These peptides are believed to account for about 145 residues of fragment C-1, the N-terminal section of rabbit immunoglobulin G heavy chain prepared by cyanogen bromide cleavage. The evidence from the present paper and the preceding paper (Cebra, Givol & Porter, 1968) suggests that it may be possible to deduce a predominant amino acid sequence for most, if not all, of this section of the molecule.


Action of rifamycins on RNA polymerase.

Action of rifamycins on RNA polymerase.


Biogenesis of peptide antibiotics. I. Dynamics of antimycin A biosynthesis by Streptomyces antibioticus NRRL 2838.


Tritiated thymidine effects on DNA, RNA, and protein synthetic rates in synchronized L-cells.


Effect of o,p'-DDD and similar compounds on thyroxine binding globulin.


Wiskott-Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity.


Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever.


Pulmonary alveolar proteinosis associated with IgG monoclonal gammopathy.


Prostatic surgery and the cardiovascular patient.


Performance of a hinged metal knee prosthesis. A case report with a follow-up of three and one-half years and histological and metallurgical data.


Premeiosis and premeiotic DNA synthesis in the left ovary of the female chick embryo.


A light and electron histochemical approach to the node of Ranvier and myelin of peripheral nerve fibers.


The fine structure of ceroid in human atheroma.


The location of onuphic acid in Hyalinoecia tubicola.


Correlated histochemical staining and S35O4- labeling of salivary gland mucosubstances.


Observations on mitochondrial staining for succinic dehydrogenase.


Localization for electron microscopy of nucleoside phosphatases in human liver.


Serum proteins and endotoxins in chronic ulcerative colitis.


Variations in embryospecific globulins of human blood sera in foetuses and the newborn.


Cancer of male breast. II.

Cancer of male breast. II.


Only an appendix.

Only an appendix.


Teraphloid-diploid mosaicism in a surviving infant.


Uveal effusions.

Uveal effusions.


Studies on plasma cholinesterase isoenzymes in glaucoma.


Renal transplantation in the inbred rat. II. An immunohistochemical study of acute allograft rejection.


Biologically effective immunization against angiotensin.


Congenital sensory neuropathy with anhidrosis.


Immunochemical estimation of some proteins in Nigerian paired maternal and fetal blood.


Changes in structure of coronary arteries: susceptibility to arteriosclerosis in old rats.


Sequential renal changes in choline deficient weanling rats. Conventional and electron histochemistry.


Distribution of immunoglobulins in human rectal mucosa. I. Normal control subjects.


Enterochromaffin cells and 5-hydroxytryptamine in the human intestinal tract.


Distribution of immunoglobulins in human rectal mucosa. II. Ulcerative colitis and abnormal mucosal control subjects.


he use of radiation in the management of cancer of the colon and rectum.


Response and specificity of antibodies for Candida albicans. Rabbit antibodies for Candida albicans, reacting in agglutination and fluorescent-antibody reactions, were present in both IgM and IgG protein fractions. The two types of immune globulins were separated from ammonium sulfate-precipitated gamma-globulin either by filtration through a column of Sephadex G-200 or by diethylaminoethyl column chromatography performed by stepwise elution with various concentrations of sodium chloride. In the fluorescent-antibody test, initial separation of the IgG fraction, prior to its conjugation with dye, proved to be essential for the high specificity of this reaction. Investigation of the specificities of the two types of antibodies revealed that the IgG was highly specific, whereas the IgM was not very specific. Each antigen fraction, extracted by various methods, demonstrated its own characteristic antibody response. Only the IgG fraction yielded serotype-specific antibody useful for detection of a serotype of C. albicans in agglutination and fluorescent-antibody tests. The results indicate the importance of IgG for specific serological reactions with the Candida species.


Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice.


Effect of structural and stereochemical methylproline isomers on actinomycin biosynthesis. The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3- >4- >5-methyl-dl-proline. Cis-3-methyl-dl-proline was 14 times more active than the trans isomer. It was also found that 4- and, possibly, 5-methylproline were incorporated into the actinomycin molecule. When 4-methylproline was present, three new actinomycins, representing 50 to 60% of the antibiotic mixture, were synthesized. Growth of the organism may be stimulated at concentrations (0.1 to 1.0 mug per ml) of 3-methylproline that inhibit antibiotic formation, thus providing additional evidence for a different mechanism of actinomycin synthesis from that of protein synthesis. Azetidine-2-carboxylic acid, piperdine-2-carboxylic acid, and hydroxyproline (but not sarcosine) reversed the inhibition due to 3-methylproline.


Serum complement in the rejection of sarcoma I ascites tumor grafts.


"Protein A" from Staphylococcus aureus. IV. Production of anaphylaxis-like cutaneous and systemic reactions in non-immunized guinea-pigs.


Reversed type allergic skin reactions by anti-gamma-E-globulin antibodies in humans and monkeys.


Antibody responses in rabbits to the group B arbovirus Kumjin: serologic activity of the fractionated immunoglobulins in homologous and heterologous reactions.


Homocytotropic antibody response in the rat infected with the nematode, Nippostrongylus brasiliensis. II. Characteristics of the immune response.


Homocytotropic antibody response in the rat infected with the nematode, Nippostrongylus brasiliensis. 3. Characteristics of the antibody.


Passive hemagglutination procedures for protein and polysaccharide antigens using erythrocytes stabilized by aldehydes.


Aseptic methods in the operating suite. 2. The operating suite and equipment.


Anticoagulant and antimalarial action of heparin in simian malaria.


Enhancement of replication of vesicular stomatitis virus in human lymphocyte cultures treated with heterologous anti-lymphocyte serum.


Effect of penicillamine on failure of renal acidification in Wilson's disease.


Ectopic growth-hormone production and osteoarthropathy in carcinoma of the bronchus.


Effects of salicylates on human platelets.


Role of the kidney in fibrinolytic activity of blood.


Development and course of extrahepatic portal obstruction in children.


Collapse of left lung induced by artificial airway.


Catecholamines in phaeochromocytoma. Normal storage but abnormal release?


Jejunal biopsy modified for paediatric use.


Flexibility and experiment.

Flexibility and experiment.


Sampling of foetal blood.

Sampling of foetal blood.


Plague in Vietnam.

Plague in Vietnam.


Operative decompression in intestinal obstruction.


Immunology and human evolution.

Immunology and human evolution.


Mental health of East London.

Mental health of East London.


Virus and kidney.

Virus and kidney.


Lung scanning and pulmonary embolism.

Lung scanning and pulmonary embolism.


Infantile rickets persists in Glasgow.

Infantile rickets persists in Glasgow.


Heroin dependence. A community experiment in therapeutics.


Draughts or should I close the window?

Draughts or should I close the window?


The Royal Commission.

The Royal Commission.


Caring for old people.

Caring for old people.


Brain operation for gambler.

Brain operation for gambler.


Glucagon in sulphonylurea hypoglycaemia?


Chromatin-positive and XYY boys in approved schools.


The preconceptual menstrual period.

The preconceptual menstrual period.


Iron in Brunner's glands in haemosiderosis.


Mortality trends of renal disease.

Mortality trends of renal disease.


Amenorrhoea after oral contraceptives.

Amenorrhoea after oral contraceptives.


Inhibition of demand pacemakers.

Inhibition of demand pacemakers.


Experimental diabetes due to insulin inhibition.


Age and lymphocyte-nucleic-acids.

Age and lymphocyte-nucleic-acids.


Origin of bacteria in bileduct bile.

Origin of bacteria in bileduct bile.


Dietary sugar and serum-cholesterol.

Dietary sugar and serum-cholesterol.


Enzymes in Down's syndrome.

Enzymes in Down's syndrome.


Clioquinol for diarrhoea?

Clioquinol for diarrhoea?


Evaluation of a new diagnostic test.

Evaluation of a new diagnostic test.


Epileptic fits and amitriptyline.

Epileptic fits and amitriptyline.


Peristalsis and sympathetic activity.

Peristalsis and sympathetic activity.


L.E. cells after oral contraceptives.

L.E. cells after oral contraceptives.


Modified resin for hyperkalemia.

Modified resin for hyperkalemia.


Heart-block in hypebaric oxygen.

Heart-block in hypebaric oxygen.


Tonic pupil after temporal arteritis.

Tonic pupil after temporal arteritis.


Automated examination techniques.

Automated examination techniques.


Cystic fibrosis of the pancreas.

Cystic fibrosis of the pancreas.


Aspartic acid and cancer.

Aspartic acid and cancer.


Gastric factor in iron absorption.

Gastric factor in iron absorption.


Therapeutic abortion.

Therapeutic abortion.


Spontaneous evolution of a shoulder presentation.


Uncoating and development of vaccinia virus in miniature cells induced with an extract from marine algae.


Glial alpha-glycerophosphate dehydrogenase and central myelination.


Structural units in chromatin and their orientation on membranes.


Critical re-evaluation of immunosuppressive therapy in canine renal allografts.


Cholera studies in non-human primates. 8. Comparison of methods for the enumeration of immunologically active cells and early immune globulin, precipitin, vibriocidin and antitoxin formation.


Primary acquired lactase deficiency with acquired hypogammaglobulinemia. Report of a case and review of the literature.


Cytoplasmic changes in pancreatic acinar cells of the rat caused by one-aminocyclopentane carboxylic acid (ACPC).


The infantile sella turcica. New roentgenologic and anatomic concepts based on a developmental study of thsphenoid bone.


Cirrhotic (hepatic) lobular glomerulonephritis. Correlation of ultrastructural and clinical features.


The use of logical flow charts as an aid in teaching roentgen diagnosis.


Unusual congenital anomalies in the inner ear.


Patterns of keratinization in oral leukoplakia.


Oral contraceptives--choice of product.

Oral contraceptives--choice of product.


Chromatographic patterns of uroproteins.


The measurement of the synthetic rate of albumin in man.


Congenital insensitivity to pain in an imbecile boy.


Effect of selected experimental conditions on penetration and maturation of cercariae of Schistosoma mansoni in mice. II. Parasite-related conditions.


Binding of dihydrostreptomycin to ribosomal subunits.


Structure of the poliovirus replicative intermediate RNA.


The myenteric plexus in drug-induced neuropathy.


The paradox in therapeutic defibrination.


Immunological restitution in lymphopenic immunological deficiency syndrome.


Evidence that there are two forms of fluoride in human serum.


Relation between rat slow alpha-2-globulin and alpha-2-macroglobulin of other mammals.


Polymelanosomes of the melanocyte and their substructures.


Analysis of the mucopolysaccharide of a myxoma of the mandible.


Specificity of carcinogenic action in F-nor-steranthrene hydrocarbons.


Naturally occurring antibodies to the cuticle of nematodes.


A comparative study of symptom relief in esophageal cancer with the development of a useful index of palliation.


Dawson's encephalitis.

Dawson's encephalitis.


Benign and malignant tumors of the small intestine.


Pernicious anemia and immunologic deficiency.


When do we let the patient die?

When do we let the patient die?


Electrophoretic analysis of serum proteins from paralyzed and unparalyzed chickens exposed to Marek's disease.


Paraproteinaemia.

Paraproteinaemia.


Staining of the reducing material in the tubero-hypophysial system of the rat with osmium tetroxide.


The effects of alpha-methyl-3, 4-dihydroxy-L-phenylalanine (methyldopa, Aldomet) on erythrocytes.


Metachromasia and alcian blue staining of the intervertebral disc of the cat.


Reduced articular processes of thoracic vertebrae, a 'minor skeletal variant' in the mouse.


The overhead projector and transparencies.


Nonbook media in nursing education.

Nonbook media in nursing education.


Lymphoma--meningitis. Listeria meningitis and septicemia in an adult with malignant lymphoma.


Observations on the morphology and histochemistry of the oviducts of the sheep.


The effect of 6-mercaptopurine on the turnover of I-131-gamma globulin and I125-albumin in rabbits.


Developmental aphasia: a speculative view with therapeutic implications.


Positive and negative colloidal iron as cell surface electron stains.


Alterations in the liver due to acute amino acid deficiency. An electron microscopic study of young rats force-fed a threonine-devoid diet.


Plasma 3S gamma-1-globulin: identity with erythrocyte carbonic anhydrase B. The 3S (gamma1), 2S (gamma2), and 0.5S (gamma2) fractions of human plasma are heterogeneous in protein composition. Although each fraction contained a relatively small amount of protein antigenically related to the immunoglobulin light chains, most of the proteins were unrelated to immunogloublin G or its light chains. Of the 3S (gamma1)-globulins the greater part was immunochemically identical to carbonic anhydrase B and had carbonic anhydrase activity. These findings explain earlier reports of an immunochemical similarity between 3S (gamma1)-globulins and immunoglobulin light chains in spite of marked differences in amino acid and peptide composition between the two. Apparently not all plasma gamma-globulins are necessarily immunoglobulins.


Medication in child psychiatry.

Medication in child psychiatry.


Environmental hazards associated with a radio frquency pacemaker.


On prognosis and rehabilitation in schizophrenic and paranoid psychoses. A comparative follow-up study of two series of patients first admitted to hospital in 1950 and 1960 respectively.


Structure and biological properties of immunoglobulins.


A histochemical study of epithelial mucin in the chick chorioallantois.


Human gamma globulin in the treatment of bacterial infections.


Physical and chemical differences between rabbit antibodies to the 2,4-dinitrophenyl and the 2,4,6-trinitrophenyl groups.


Effect of thyroid hormones on the intestinal transport of valine in vitro.


Periodic hypersomnia.

Periodic hypersomnia.


Contribution to the histochemistry of Toolan's human adenocarcinoma "1U" (H.Ad. + 1U) i hamster cheek pouch.


Effect of lymphoid leukosis and Marek's disease on the immunological responsiveness of the chicken.


Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues.


A simple procedure for high-efficiency radioiodination of proteins.


Conservative treatment of gangrene using mineralocorticoid-induced moderate hypertension.


The effect of cations on the binding of 3,4-benzpyrene by plasma proteins.


Surgery of the esophagus (concluded).

Surgery of the esophagus (concluded).


Assessment of abnormalities in intellectual development.


2-chain immunoglobulin A molecules: abnormal or normal intermediates in synthesis. Immunoglobulin A (gammaA) myeloma proteins secreted by plasma-cell tumors of mice are of two types, a common four-chain molecule and a rare two-chain (3.9S) molecule. The close similarity between two-chain gammaA molecules and four-chain gammaA molecules and their polymers is demonstrated in tryptic peptide maps of isolated polypeptide chains and by precipitin reactions with rabbit antiserums to gammaA immzunoglobulins. However, a difference between these two types is distinguishable with homologous antiserums. Homologous antiserums to two-chain gammaA immunoglobulins are specific and do not cross-react with four-chain gammaA immutnoglobulins.


Allergic reactions to mercury in red tattoos and in mucosa adjacent to amalgam fillings.


Cross-sensitization among nitrofurylaminothiadiazoles.


The presence of Langerhans cells in human dermis with special reference to their potential mesenchymal origin.


A new treatment of ichthyosis and other hyperkeratotic conditions.


Fine structure of interphase nuclei. (An experimental study with critical review of preparatory methods).


Squamous cell carcinoma in psoriasis vulgaris. Three cases of squamous cell carcinoma developing in psoriatic lesions.


Ultrastructural evidence related to monoamine-storage in the axoplasm of unmyelinated nerves of human dermis.


Lysosomes in Fabry's disease.

Lysosomes in Fabry's disease.


Cancer to the mxillary sinus in a patient with the basal-cell nevus syndrome.


Vitiligo with raised borders. Report of two cases.


Darier's disease and cystic changes of the bones.


Early congenital syphilis and thrombocytopenia.


Evaluation of drug influence on the itch duration in the skin of patients with atopic dermatitis, various eczemas and psoriasis. I. Experiments in involved skin. Comparison with itch threshold technique.


Evaluation of drug influence on the itch duration in the skin of patients with atopic dermatitis, various eczemas and psoriasis. II. Experiments in unaffected skin. Comparison with itch threshold technique and clinical evaluation.


Histamine release produced in human skin by compound 48:80.


Effective oral nasal decongestion. A double-blind, crossover analysis.


Hypersensitivity responses in monkeys. Histamine, skin response, 48-80, passive transfer (man to monkey, monkey to monkey) and other features related to human reactivity.


Occlusion of plasma proteins by human fibrin: studies using trace-labelled proteins.


Spirochete from the rabbit tick, Haemaphysalis leporispalustris (Packard). I. Isolation and preliminary characterization. An unidentified spirochete, referred to as the 277F agent, was isolated from Haemaphysalis leporispalustris ticks from two cottontail rabbits by inoculation of the tick suspension into embryonated chicken eggs. Because of its minute width (0.1 mu), the organism was difficult to see when stained by the Giemsa method, but was readily demonstrated by silver impregnation or fluorescent-antibody procedures. In dark-field microscopy, the spirochetes appeared uniformly and rather tightly coiled, and exhibited typical corkscrewlike motility. After yolk-sac inoculation, the agent was highly lethal for chick embryos and was recovered in large quantity from several embryonic tissues and fluids. It could also be maintained in nonfertile eggs and in an enriched liquid medium. This previously undescribed spirochete could pass through Berkefeld N but not Seitz EK filters. It was relatively resistant to heat and to penicillin or sulfadiazine, but was markedly inhibited by streptomycin, broad-spectrum antibiotics, and homologous neutralizing antiserum. Of several species of animals tested for susceptibility to this spirochete, only the snowshoe hare gave evidence of infection.


Human renal transplants. II. Immunofluorescent and immunoferritin studies.


Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach.


CCTV and tape recorders help extend the dietitian's "reach".


Hormonal regulation of liver enzyme synthesis.


Intravenous gamma globulin. Metabolism of gamma globulin fragments in normal and agammaglobulinemic persons.


A fetal serum protein in a new role.

A fetal serum protein in a new role.


Alpha-1 fetoglobulin in the diagnosis of human hepatoma.


Contributions to the study of blood constituents in domestic animals in South Africa. 6. Normal values for serum protein fractions in sheep as obtained by electrophoresis on cellulose acetate strips.


Ultrastructure of the thyroid in a case of Hashimoto goitre. (Struma lymphomatosa).


Effect of plasma cell tumor on antibody production by mouse spleen cells.


Consequences of natural exposure to rubella during pregnancy.


The effects of estradiol valerate upon the serum and bone of the lizard Scleoporus cyanogenys.


Separation and identification of aromatic carbonyl compounds as their 4-nitrophenylhydrazones by paper and thin-layer chromatography.


Orientation with tapes and slides.

Orientation with tapes and slides.


The skin window as a diagnostic tool in pediatric allergy.


A new apparatus for use in the cryotherapy of prostate obstruction.


Anticoagulant therapy as a potentially effective method for the prevention of presenile dementia: two case reports.


A study of possible proteolytic enzymes in human skin by a silver protein method.


Mortality and hardness of local water-supplies.


Aseptic methods in the operating suite. 3. Preparation of the patient and performance of the operation.


Significant bacteriuria after major gynaecological surgery.


Serum-fructose levels after sucrose or its constituent monosaccharides.


Report of a sub-committee on quantitation of muscle biopsy findings. Appendix B to the Minutes of the Meeting of the Research Group on Neuromuscular Diseases, held in Montreal, Canada, on 21 September, 1967.


Prophylaxis of influenza with a synthetic isoquinoline.


Nail-fold capillaries in connective-tissue disorders.


Clinical study of eight children with visual dysfunction and educational problems.


Foot-and-mouth disease.

Foot-and-mouth disease.


Carnosinaemia.

Carnosinaemia.


Addiction new style.

Addiction new style.


Drug dependence: a symptom.

Drug dependence: a symptom.


Penfield on memory.

Penfield on memory.


Toxic effects of busulphan.

Toxic effects of busulphan.


The heart in hypertension.

The heart in hypertension.


Psychiatric care of the adolescent.

Psychiatric care of the adolescent.


When should randomisation begin?

When should randomisation begin?


Medical students and general practice.

Medical students and general practice.


Early discharge after hernia repair.

Early discharge after hernia repair.


A new approach to anticoagulant therapy?


M.C.Q. and the membership.

M.C.Q. and the membership.


Dermatoglyphics in partial C trisomies.

Dermatoglyphics in partial C trisomies.


Measurement of blood-glucose levels.

Measurement of blood-glucose levels.


Pancreozymin and serum-insulin levels.

Pancreozymin and serum-insulin levels.


Cancer and dermatoglyphics.

Cancer and dermatoglyphics.


Failure of ampicillin in meningitis.

Failure of ampicillin in meningitis.


Lipomucopolysaccharidosis?

Lipomucopolysaccharidosis?


Lignocaine for arrhythmias.

Lignocaine for arrhythmias.


Oral contraceptives and cell replication.


Pregnancy after mitral-valve prosthesis.


Transient iminoaciduria in pyelonephritis.


Chromosomes in juvenile breast cancer.

Chromosomes in juvenile breast cancer.


Parenteral methotrexate for psoriasis.

Parenteral methotrexate for psoriasis.


Hypocalcemic fits in neonates.

Hypocalcemic fits in neonates.


Effect of shower-bathing on dispersal of recently acquired transient skin flora.


Histocompatibility antigens in choriocarcinoma.


Inheritance of calcium renal stones.

Inheritance of calcium renal stones.


Antilymphocyte serum.

Antilymphocyte serum.


Ethyl alcohol and porphyrin metabolism.

Ethyl alcohol and porphyrin metabolism.


Riley virus in wild mice.

Riley virus in wild mice.


Pulmonary blood-volume in high-altitude pulmonary oedema.


Diazepam for treatment of phobias.

Diazepam for treatment of phobias.


In-vivo storage of primate kidneys.

In-vivo storage of primate kidneys.


Renal failure in nephrotic syndrome.

Renal failure in nephrotic syndrome.


Failure of methimazole to affect peripheral thyroid indices in man.


In vitro histamine release from blood cellular elements of rabbits infected with Schistosoma mansoni.


Early and late effects of growth hormone on the rat diaphragm.


Congenital pulmonary atresia with ventricular septal defect. Review of the clinical course of fifty patients with assessment of the results of palliative surgery.


The kidney in blackwater fever: light and electron microscopic observations.


Hyaline globules of the adrenal medulla.


Serum protein fractions in patients with Down's syndrome (mongolism).


Forehead flap reconstruction of the floor of the mouth.


Data processing and the operating room nurse.


Testing students learning of surgical asepsis in the operating room.


The OR technician--assistant or adversary?


Communicating with the deaf patient in the operating room.


Editorial: on aggressiveness.

Editorial: on aggressiveness.


Plasma protein changes in normal, thymectomized, and bursectomized chickens during a Plasmodium lophurae infection.


Some features of the immunological unresponsive state induced in rats to cestode antigens.


Antigenic determinants specific for aggregated gamma G-globulins.


A simple and rapid method for cold staining of tuberculosis bacillus.


The isolation of immunoglobulins of the adult opossum (Didelphys virginiana).


Assignment of direct and facilitated hemolytic plaques in mice to specific immunoglobulin classes.


Transfer of cutaneous hypersensitivity to tuberculin in the guinea pig by gamma G2 from immunized donors.


Tolerance in vitro: suppression of immune responsiveness to bovine gamma-globulin after injection of antigen into intact lymphoid organs.


Carbodiimide-induced bentonite-antigen complexes: readily prepared immunoadsorbents.


Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture.


Comparison of thyroid secretion rates in chickens as determined by (1) goiter preventin, (2) thyroid hormone substitution, (3) direct output and (4) thyroxine degradation methods.