Pulse-radiolysis and spectral studies of the interaction of cetylpyridinium chloride and methylene blue with connective-tissue glycosaminoglycans and related compounds. 1. Hydrated electrons produced by pulse radiolysis were used to study the interaction of polyanionic glycosaminoglycans and related compounds with the counterions Methylene Blue and cetylpyridinium chloride. 2. The effect of added salt (potassium chloride) on the interaction indicates that the relative binding affinities, with respect to the types of anionic site present, increases for both counterions in the order CO(2) (-)<CO(2) (-)+O.SO(3) (-)<CO(2) (-)+O.SO(3) (-) +N.SO(3) (-)<O.SO(3) (-). The interactions of the polyanions with cetylpyridinium chloride are considerably stronger than those with Methylene Blue. 3. The effects of added salt on the metachromasia resulting from polyanion-Methylene Blue interaction were examined spectrophotometrically. 4. The collective results demonstrate a direct relationship between anionic site-dye binding and metachromasia, although a residual dye binding can be detected by pulse radiolysis when metachromasia is completely removed.


Selective effects of a new metal-complexed azo dye on proteins of the Reed-Sternberg cell.


Alpha-1 acute-phase globulins of rats. Isolation and some properties. 1. A method is described for the isolation of certain of the alpha(1)-globulins of rat plasma that are known to increase in concentration after tissue damage (acute-phase globulins). 2. Although apparently homogeneous when examined by disc electrophoresis at pH9, these proteins could be subdivided further by isoelectric fractionation. 3. Treatment with neuraminidase removed approx. 60% of the sialic acid originally present in these proteins and gave almost completely homogeneous material of decreased mobility when examined by disc electrophoresis in polyacrylamide gel. When subjected to immunoelectrophoresis this material gave a single arc. 4. The homogeneity of the isolated materials was examined by ultracentrifugation. The single peak thus found is consistent with molecular weights of 45000-46000. 5. The isolated materials were shown to be glycoproteins containing approx. 15% of carbohydrate, and to have isoelectric points in the range pH4.4-4.8.


Cellular differentiation of the immune system of mice. V. Class differentiation in marrow precursors of plaque-forming cells. Marrow cells and thymocytes of unprimed donor mice were mixed in vitro and transplanted into X-irradiated syngeneic hosts. 18 hr later sheep erythrocytes were injected to induce immune responses. Splenic plaque-forming cells (PFC) secreting IgM (direct PFC) or IgG (indirect PFC) hemolytic antibody were enumerated at the time of peak responses. By transplanting graded and limiting numbers of marrow cells with 5 x 10(7) thymocytes, inocula were found that contained few precursors of PFC (P-PFC) reaching the recipient spleens, interacting with thymocytes, and generating PFC. However, the frequency of responses in relation to the number of grafted marrow cells did not follow Poisson statistics, presumably because the interaction of marrow cells with thymocytes was more complex than a single or a one-to-one cell event. The frequency of direct PFC responses was greater than that of indirect PFC responses in 13 of 15 groups of mice tested. This was interpreted as evidence for the existence of two classes of P-PFC, each of which was restricted to generate either direct or indirect PFC. The precursors of direct PFC were approximately 15 times more frequent than those of indirect PFC. Since thymic antigen-reactive cells were not differentiated for antibody class, it follows that antigen-sensitive units reactive to sheep erythrocytes owe their class restriction to specialized marrow cells. Specialization of P-PFC may have arisen within marrow cell lines by differentiation, or may have been conferred upon P-PFC by interaction with other cells, including those of the irradiated host.


Cellular differentiation of the immune system of mice. IV. Lack of class differentiation in thymic antigen-reactive cells. Thymocytes and marrow cells of unprimed donor mice were mixed in vitro and transplanted into X-irradiated syngeneic mice. 18 hr later, sheep erythrocytes were injected to induce immune responses. Splenic plaque-forming cells (PFC) secreting IgM (direct PFC) or IgG (indirect PFC) hemolytic antibody were enumerated at the time of peak responses. By transplanting graded and limiting numbers of thymocytes with 4 x 10(7) marrow cells, inocula were found which contained one or a few thymic antigen-reactive cells (ARC) reaching the recipient spleens, interacting with marrow cells, and inducing PFC formation. The frequency values of ARC inferred from direct and indirect plaque assays were very similar, 1 in approximately 10(7) thymocytes. Furthermore, statistical analysis indicated that the formation of direct PFC was not independent of the formation of indirect PFC. This was interpreted to mean that ARC were not specialized themselves and did not determine the molecular class of antibody to be secreted after interaction with marrow cells. Spleens of thymus-marrow grafted mice containing one or two ARC and non-limiting numbers of marrow precursors of PFC (P-PFC), had direct and indirect PFC clustered in several focal areas. Assuming that each focal area represented the progeny of one P-PFC that had interacted with ARC, these results confirmed the statistical evidence for lack of class differentiation in thymic ARC, and also indicated that each ARC or its progeny cells interacted with more than one P-PFC of either class.


C3 leukotactic factors produced by a tissue protease. When various rat tissues are incubated in homologous serum, a factor chemotactic in vitro for neutrophils is generated. The amount of chemotactic activity is a function of duration of incubation and the quantity of heart tissue or serum employed. Addition of trypsin inhibitor or antibody to the third component of complement (C3) precludes generation of chemotactic activity. In addition, antibody to C3 ablates chemotactic activity even after its formation. Purified human C3 (beta(1C)-globulin) effectively substitutes for serum in the generation of chemotactic activity by heart tissue. The active product, as determined by gel filtration or by ultracentrifugal analysis in a sucrose density gradient, appears to be a cleavage product of C3 with a molecular weight of approximately 14,000. In addition, a larger C3 fragmentation product varying in molecular weight, depending upon experimental conditions, is also found. The protease in rat heart tissue capable of cleaving C3 into chemotactic fragments is a serine esterase with trypsin-like properties and can be inhibited by organophophorous compounds or trypsin inhibitors. The use of amino acid esters in the manner of competitive substrate inhibition confirms the trypsin-like nature of the protease. The presence of a protease in heart, and presumably in other normal tissues, capable of fragmenting C3 into factors with chemotactic activities may explain the development of the acute inflammatory response when tissues are non-specifically injured. If true, this would reinforce the role of the complement system in the mediation of nonimmunologically induced inflammation.


Crossing over between genes in the immunoglobulin heavy chain linkage group of the mouse. Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N. C., two new heavy chain linkage groups, G(3,5,7,8)H(9,11)F(f)A(-) and G(3,5,8)H(9,11)F(f)A(-), were found, each of which genetically controls both the 3 and 5 distinct immunoglobulin determinants. In inbred strains the 3 and 5 determinants are found independently. The new heavy chain allotype G(3,5,7,8)H(9,11)F(f)A(-) probably arose from a homologous (intragenic) cross-over between G(3,8)H(9,11)F(f)A(-) and G(5,7,8)H(9,11)F(f)A(14) heavy chain linkage groups. It was suggested that genes controlling G(3,8)G(5,7,8), G(3,5,8), and G(3,5,7,8) are alleles. Another homozygous wild mouse (Kyushu, Japan) showed a new heavy chain allotype, (2)G(1,6,7,8)H(9,16)F(s)A(15). The 2 and G(1,6,7,8) determinants are also separated in inbred strains. The 2 determinant in inbred mice is not on the gammaF, gammaH, or gammaA heavy chain and is probably on a gammaG or gammaG-like immunoglobulin heavy chain. Papain digestion of serum from the Kyushu mouse showed two electrophoretically different Fc fragments, one carrying the G(1,6,7,8) and the other the 2 determinant. The new heavy chain allotype, (2)G(1,6,7,8)H(9,16)F(s)A(15), of the Kyushu wild mouse probably arose from a nonhomologous (unequal) cross over between (2)G(-)H(9,16)F(s)A(15) and G(1,6,7,8)H(9,11)F(f)A(12,13,14) heavy chain linkage groups. The linkage group of the Kyushu wild mouse has at least five heavy chain genes, while that of the inbred mice has four.


Idiotypy of rabbit antibodies. II. Comparison of idiotypy of various kinds of antibodies formed in the same rabbits against Salmonella typhi. The idiotypic patterns detected in the anti-Salmonella typhi serum of one given bleeding have been sought in other bleedings of the same rabbit. Idiotypic patterns carried by antibodies of the second bleeding are not always found in those of the first bleeding. Bifurcated precipitation zones in gels (double diffusion in cells) have been observed in the reaction of several anti-idiotypic sera with the sera of the first and second bleedings of three rabbits, and apparently indicate that idiotypic patterns which were carried by the same molecule in the first bleeding were carried by two separate molecules in the second bleeding. In a comparison of idiotypy of two anti-S. typhi serum samples of one rabbit, the collection of which had been separated by a very long interruption of the immunization, all the idiotypes detected in the early bleeding were also detected in the late bleeding; several idiotypes were detected in the serum of the late bleeding and not in that of the early bleeding. Idiotypy has been observed and compared in IgM and in IgG antibodies. There are, in each of these two classes, antibodies that are not distinguished from antibodies of the other class by anti-idiotypic sera, and consequently that carry the same idiotypic patterns. A comparison has been made between the idiotypy of the two kinds of antibodies which, in anti-S. typhi sera, are precipitated and not precipitated by the polysaccharide. Certain idiotypic patterns are carried only by the antibodies of the first kind. There are also idiotypic patterns which are carried by antibodies of these two kinds, among which certain anti-idiotypic antibodies do not discriminate. Possible cellular implications of observations made on idiotypy at different stages of the immunization of one individual have been discussed.


Water-borne epidemic of infectious hepatitis at Ustí nad Labem in 1965.


Genetic counselling in X-linked muscular dystrophy.


Canine proliferative and necrotizing tracheobronchitis, with intranuclear inclusion-body and hyaline membrane formation.


Alpha-1-antitrypsin deficiency and chronic pulmonary disease.


Alprenolol during halothane anaesthesia in surgical patients.


The effect of anionic, cationic, and nonionic detergents on the percutaneous absorption of sodium chromate (51Cr) in the guinea pig.


Ultrastructural localization of aryl sulfatase in human epidermis.


Oxygen consumption of the germinal epithelium in psoriatic human skin as measured by the Cartesian diver micro-gasometer.


Argininosuccinic aciduria in hereditary hair diseases.


Aminoaciduria in xeroderma pigmentosum.

Aminoaciduria in xeroderma pigmentosum.


Observations on the granularity of mast cells in human skin.


The occurrence of certain serum factors in the dermal-epidermal junction and vessel walls of the skin in lupus erythematosus and other (skin) diseases.


Contact dermatitis due to spandex.

Contact dermatitis due to spandex.


The blood platelets in immune hypersensitivity.


The histopathological and cytological diagnosis of cutaneous leishmaniasis in two cases of leishmania tropica.


Congenital skin defects.

Congenital skin defects.


Letterer-Siwe's disease.

Letterer-Siwe's disease.


Langerhans cells in the human sebaceous gland and external hair sheath in Letterer-Siwe's disease.


Neurotrophic ulcer associated with the Wallenberg syndrome.


Immunological aspects of pemphigus and its treatment with antipolio vaccande (Sabin) in steroids.


Histochemical types and sizes of fibres in normal human muscles. A biopsy study.


Axonic swellings demonstrated by a supravital methylene blue technique.


Effect of chlorpromazine on the fine structure of rabbit blood platelets.


Quantitative and histochemical studies on the desorption and readsorption of aldolase in cross-striated muscle.


Bronchogenic carcinoma: changing concepts of management with irradiation.


Intracellular localization of catalase (peroxidatic) activity in plant microbodies.


Experimental studies on the tumour inhibitory effect of heparin-degranol (Zitofenton).


Microelectrophoresis in agarose gel of soluble rat liver proteins during aminoazo dye carcinogenesis.


The affinity of cultured cells for a silver salt after viral inoculation.


The localization of prostatic carcinoma. An autopsy study.


Hypertrophy of the prostate. Duration of preoperative treatment and operative mortality.


Immunoglobulin levels in patients with abscess formation.


Protein-bound iodine during antithyroid treatment.


Urinary excretion of free and conjugated histamine in various gastrointestinal disorders.


Treatment of immunologic diseases with cytostatics.


Histogenesis of the lens capsule in tissue culture.


Serum immunoglobulins and organ-specific, cellular hypersensitivity in ulcerative colitis and Crohn's disease.


Carbon monoxide hazard in city traffic. An examination of traffic policemen in three Swedish towns.


Image, symbol, and person. The strategy of psychological defense.


The microvascular architecture of the rat submaxillary gland: possible relationship to secretory mechanisms.


Disseminated infection caused by Mycobacterium kansasii. Report of a case and brief review of the literature.


Application of the zinc iodide-osmium tetroxide impregnation of synaptic vesicles in cephalopod nerves.


Immunological and chromosomal studies in first-degree relatives of children with acute lymphoblastic leukaemia.


Fate of iodide derived from intrathyroidal hyrolysis of thyroglobulin.


Dendritic spines in the visual cortex of the mouse: introduction to a mathematical model.


Headache and the dry nose.

Headache and the dry nose.


Histamine release by some muscle relaxants.


Adsorptions of purified serum proteins on metalized glass slides and their significance for the immunoelectroadsorption method.


Spongy degeneration in the white matter of the central nervous system in the newborn: pathological findings in three infants, one with hyperglycinaemia.


Electron microscopy of giant-cell (temporal) arteritis.


Encephalitis with myoclonus in Whipple's disease.


The cytodiagnosis of prostatic cancer.

The cytodiagnosis of prostatic cancer.


Clive Marshall Samuel, M.B.E., T.D., M.B. Lond., M.R.C.G.P., D.I.H., D.P.H.


Urinary osmolality in acute renal failure due to glomerulonephritis.


Effect of suction on blood-flow in ischaemic limbs.


Pseudomyxoma peritonei.

Pseudomyxoma peritonei.


Thermographic patterns in pulmonary vascular disease.


Intranasal adminstration of HPV-77 rubella vaccine grown in WI-38. Lack of infection by this route.


Effect of folic-acid supplement on serum-vitamin-B12 levels in patients on anticonvulsants.


An apnoea-alarm mattress.

An apnoea-alarm mattress.


Measurement of vibro-tactile threshold in peripheral nerve injury.


All together now.

All together now.


M.M.R. in the seventies.

M.M.R. in the seventies.


Alcohol and the blood.

Alcohol and the blood.


Dispensing in the country.

Dispensing in the country.


Leprosy.

Leprosy.


Slicing machines.

Slicing machines.


Structure of cartilage.

Structure of cartilage.


The health team in the community.

The health team in the community.


Medicine, a humane science.

Medicine, a humane science.


Biological rancidification.

Biological rancidification.


Diabetic ketoacidosis during acute heroin abstinence.


The responsibilities of the consultant grade.


Pentazocine addiction.

Pentazocine addiction.


Spread of foot-and-mouth disease.

Spread of foot-and-mouth disease.


Mycobacteria, skins, and needles.

Mycobacteria, skins, and needles.


Skin, needles and blood-samples.

Skin, needles and blood-samples.


Visiting in a children's ward.

Visiting in a children's ward.


Mother-baby contact in special-care baby units.


Asthma mortality and pressurised aerosols.


Homocystinuria, addisonian pernicious anaemia, and partial deletion of a G chromosome.


Interpreting the Abortion Act.

Interpreting the Abortion Act.


Vestibular studies in a case of congenital nystagmus.


Interpretation of the Heaf test.

Interpretation of the Heaf test.


The distending force in the production of communicating syringomyelia.


Fluoride.

Fluoride.


Catecholamine hyperpnoea.

Catecholamine hyperpnoea.


Plasma testosterone and luteinising hormone in XYY men.


Lymphocytes, anti-tumour agents, and target cells.


Oral contraceptives and prophylaxis of thromboembolism.


Irradiation of sensitised lymphocytes.

Irradiation of sensitised lymphocytes.


Haemolytic-uraemic syndrome and heparin therapy.


Hypoplastic-left-heart syndrome in siblings.


Leslie George Norman, C.B.E., M.D., B.Sc. Lond., F.R.C.P., D.P.H.


Cyril Arthur Rankin Nitch, M.S. Lond., F.R.C.S.


Interaction of adrenal and gonadal steroids with proteins in human plasma.


Hereditary deafness in man.

Hereditary deafness in man.


Genetics of immunoglobulin kappa-chains: chemical analysis of normal human light chains of differing Inv types. The relationship between Inv phenotype and the amino acid residue at position 191 in kappa-type light polypeptide chains derived from the immunoglobulins of ten normal human sera was investigated. In each case, the amino acid present at position 191 correlated with the Inv phenotype of the individual. Kappa chains of seven Inv (-1,3) homozygotes had valine, while those of three Inv (1,3) heterozygotes had some chains with leucine and some with valine at this position. Genes encoding the Inv (1) and Inv (3) variants appear to be expressed equally in the heterozygous state, since approximately equal amounts of each gene product was recovered from heterozygotes. The correlation between Inv phenotype and the amino acid residue present at position 191 is identical to that previously established for kappa-type Bence-Jones proteins and myeloma protein light chains. These observations support the hypothesis that the valine-leucine interchange is encoded by two allelic forms of a single kappa-chain common region gene.


The WHO immunology laboratories at Lausanne.


Some aspects of variability of enzymes in cellular regulation of activities.


Sarcoidosis and the acoustic nerve.

Sarcoidosis and the acoustic nerve.


Some properties of human colostral cells.


Projections from the cingulate cortex in the rat.


Phase-contrast observation on influence of ruby laser-radiation on living cells.


Charles Aubrey Pannett.

Charles Aubrey Pannett.


Present employment of University of Aberdeen medical graduates, 1956-58.


Alexander Brunschwig.

Alexander Brunschwig.


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


Blood gases and lung function.

Blood gases and lung function.


Immunological reactions involving two cell types.


Laboratory models of reaginic allergy.

Laboratory models of reaginic allergy.


Huge filling defect in the bladder caused by intravesical enlargement of the prostate.


Ventricular extrasystoles induced by epinephrine, nicotine, ethanol, and vasopressin in dogs with myocardial lesions.


Familial alpha-1, antitrypsin deficiency and pulmonary emphysema.


Primary carcinoma of the male breast.

Primary carcinoma of the male breast.


An enzymic method for the trace iodination of immunoglobulins and other proteins. 1. A method is described for the trace iodination of immunoglobulins and other serum proteins by a system consisting of lactoperoxidase, hydrogen peroxide and iodide. 2. gammaG immunoglobulin that had been labelled to a specific radioactivity of 5muc/mug. by use of carrier-free [(125)I]iodide gave no evidence of denaturation when analysed by electrophoresis and density-gradient ultracentrifugation. 3. Tryptic hydrolysis and peptide ;mapping' of a completely characterized peptide radioiodinated by this method showed that the [(125)I]iodide was bound to tyrosyl residues. 4. Proteins differ in their susceptibility to iodination by this method. Human gammaG immunoglobulin, for example, is iodinated more than ten times as readily as is human alpha(2)-macroglobulin under the same conditions. 5. Lactoperoxidase catalyses the iodination of proteins much more readily than does horseradish peroxidase.


Immunoglobulins in sow mammary secretions throughout lactation and their significance as anti-(Escherichia coli) antibodies to the young pig.


Diazotized m-aminobenzyloxymethylcellulose as the insoluble matrix for an immunoadsorbent used in the purification of antigens and antibodies.


Affinity and heterogeneity of antibodies induced by epsilon-2,4-dinitrophenylinsulin.


Induction of glomerulonephritis with streptococcal membrane antiserum.


Immunologic determination of proteins found in low concentrations in human serum.


The treatment of severe myasthenia gravis with immunosuppressive agents.


Immunoglobulins of intestinal fluids.

Immunoglobulins of intestinal fluids.


tRNA synthesis in HeLa cells: a precursor to tRNA and the effects of methionine starvation on tRNA synthesis.


C-reactive protein, immunoglobulin and serum protein analyses of sera from cases of lepromatous leprosy and tuberculosis.


Acute porphyria in a hyperthyroid patient.


Renal vascular involvement in a case of polymyalgia rheumatica with temporal arteritis. A study of successive biopsies.


Polygonal crystalline structures and crystalline aggregates of cylindrical particles in human glioma.


Myelin stain for the cultured brain tissue.


The syndrome of immunoglobulin deficiency and pernicious anemia. A study of ten cases.


Hypothalamo-hypophyseal system in the minnow, Phoxinus phoxinus L. with a note on the effects of hypophysectomy.


A critical evaluation of vaso-seminal vesiculography.


The analog computer as a training aid in nuclear medicine.


Cryosurgery of the prostate in a hyperbaric chamber.


Factors influencing early function of cadaver renal transplants.


Failure of Australia antibody to prevent post-transfusion hepatitis.


Pseudopolyposis in ulcerative colitis.

Pseudopolyposis in ulcerative colitis.


Serum-free-fatty-acids and their relation to complications after acute myocardial infarction.


Antagonism of the hypotensive action of bethanidine and debrisoquine by tricyclic antidepressants.


The vas deferens in cystic fibrosis.

The vas deferens in cystic fibrosis.


The Kveim test in Crohn's disease.

The Kveim test in Crohn's disease.


Suction amnioscope.

Suction amnioscope.


Immunological observations in chronic mucocutaneous candidiasis.


Cytological method for assessing topography of neoplastic change in endocervical canal.


Hepatitis virus.

Hepatitis virus.


Working women.

Working women.


Spread of foot-and-mouth disease.

Spread of foot-and-mouth disease.


Mothers in hospital.

Mothers in hospital.


Delivery after previous caesarean section.


Animals for research.

Animals for research.


Turista in Teheran. Travellers' diarrhoea at the Eighth International Congresses of Tropical Medicine and Malaria.


Unrestricted visiting in a children's ward. The first twenty years.


L-dopa for progressive suparanulcear palsy.


Depression during L-dopa treatment.

Depression during L-dopa treatment.


Whiplash injury and subdural haematoma.

Whiplash injury and subdural haematoma.


Dibrommanitol for chronic myeloid leukaemia.


Vascular lesions in malignant hypertension.


Psychiatric unit in a general hospital.

Psychiatric unit in a general hospital.


Crystalloid administration in shock and surgical trauma.


Oral contraceptives and hypetension.

Oral contraceptives and hypetension.


Hypertension in the African.

Hypertension in the African.


Choice of potassium supplements.

Choice of potassium supplements.


Pharmacological blockade of carcinoid flushing provoked by catecholamines and alcohol.


Pathogenesis of retrolental fibroplasia.


The significance of brain-amine concentrations.


Genetic punctuation signals.

Genetic punctuation signals.


Transfer factor in chronic obstructive bronchitis.


Mitral valve prosthesis, warfarin anticoagulation, and pregnancy.


Pregnancy diagnosis.

Pregnancy diagnosis.


A case of sarcoidosis and primary biliary cirrhosis.


Cardiac surgery and bacterial endocarditis.


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


Skins and needles.

Skins and needles.


Fenfluramine and phenmetrazine.

Fenfluramine and phenmetrazine.


The toxoplasma dye test in idiopathic retroperitoneal fibrosis.


Reaction to trifluoperazine abuse.

Reaction to trifluoperazine abuse.


A problem in peritoneal dialysis.

A problem in peritoneal dialysis.


Audiovisual aids.

Audiovisual aids.


Perception revisited.

Perception revisited.


The oto-toxic effect of streptomycin and dihydrostreptomycin on the foetus.


The effect of glutaraldehyde fixation on the elucidation of the morphogenesis of annulate lamellae in oocytes of Rana pipiens.


Ultrastructure of human labial salivary glands. II. Intranuclear inclusions in the acinar secretory cells.


Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis.


Passive transfer to human recipients of the capillarotoxic serum factor stimulated by heparin.


Reducing variability of Ptinus tectus Boield. (Col., Ptinidae) for bioassay of contact insecticides.


In situ Feulgen reaction with Schiff reagent at different temperatures.


Plan of organization is the key to effective administration.


Serum-cholesterol and ABO and rhesus blood-groups.


ABO and Lewis blood-groups and serum-cholesterol.


Hepatitis-associated antigen in chronic liver disease.


Azathioprine for Crohn's disease.

Azathioprine for Crohn's disease.


Prophylaxis of influenza B with UK 2054.


Serum-insulin in acromegaly.

Serum-insulin in acromegaly.


Synergistic effect of edetic-acid/antibiotic combinations on Pseudomonas aeruginosa.


Colchicine-like effect on astrocytes after portacaval shunt in rats.


Blood-groups and serum-cholesterol.

Blood-groups and serum-cholesterol.


Membranous glomerulonephritis.

Membranous glomerulonephritis.


What is a home?

What is a home?


The origin of faecal fat.

The origin of faecal fat.


Drug-induced lung disease.

Drug-induced lung disease.


Topical treatment of burns.

Topical treatment of burns.


Icidental splenectomy.

Icidental splenectomy.


Neonatal ophthalmia.

Neonatal ophthalmia.


Speaking at medical meetings.

Speaking at medical meetings.


Should a consultant post be permanent?

Should a consultant post be permanent?


Experimental myasthenia gravis.

Experimental myasthenia gravis.


Carcinoma-in-situ and microinvasive carcinoma of the cervix.


Chromosomal aberrations in an ovarian cystadenoma.


Beans--a source of L-dopa.

Beans--a source of L-dopa.


Voluntary sterilisation.

Voluntary sterilisation.


Who should seek consent?

Who should seek consent?


Field study of U.K.2054 against natural infection with A2-Hong Kong-68 influenza virus.


Asthma mortality and pressurised aerosols.


Medical staffing in the N.H.S.

Medical staffing in the N.H.S.


L-asparaginase and blastogenesis.

L-asparaginase and blastogenesis.


Immunosuppressive action of L-asparaginase.


Natural history of postoperative deep-vein thrombosis.


Antilymphocyte serum and the reticuloendothelial system.


Orgasm and premature labour.

Orgasm and premature labour.


Chronic granulomatous disease.

Chronic granulomatous disease.


When is the Cryptococcus dangerous?

When is the Cryptococcus dangerous?


Alchemists not imprisoned.

Alchemists not imprisoned.


The British Cancer Council.

The British Cancer Council.


Immunological mystery of coeliac disease.


Coeliac disease and diabetes.

Coeliac disease and diabetes.


Tape-slides or lectures.

Tape-slides or lectures.


Dyslexia and serum-uric-acid.

Dyslexia and serum-uric-acid.


Alkaline phosphatase in pseudogout.

Alkaline phosphatase in pseudogout.


Heparin and lipid metabolism.

Heparin and lipid metabolism.


Role of lysosomes in amelogenesis.

Role of lysosomes in amelogenesis.


Congenital, sporadic dysgammaglobulinaemia (absence of IgA and partial deficit in IgG and IgM).


Determination of sheep anti-Salmonella typhimurium immunoglobulin class by antiglobulin testing.


The occurrence of nerve fiber degeneration in brains of mice inoculated with scrapie.


Keratohyalin: extraction and in vitro aggregation. Kercatohyalin can be extracted from epidermis by 1.0 molar phosphate buffer (pH 7.0), as demonstrated histochemically and ultrastructurally. If the extracted material is dialyzed against water, it aggregates to form granules that are similar to keratolhyalin granules in size, shape, histochemical staining, and electron opacity.


A silver nitrate stain for alpha-2 cells in human pancreatic islets.


The argyrophil reaction in islet cells of adult human pancreas studies with a new silver nitrate procedure.


A simple quantitative method for alpha-amylase determinations.


Aspirin intolerance and asthma. A clinical and immunological study.


City-smoke and medical chaos.

City-smoke and medical chaos.


Selective suppression of cerebral evoked potentials to patterned light in amblyopia ex anopsia.


Changes induced in stabilized image visibility by experimental alteration of the ongoing EEG.


Long-term EEG changes during direct cortical stimulation.


Functional changes of somato-sensory system during deep sleep.


The influence of end-tidal carbon dioxide tension on EEG changes during routine hyperventilation in different age groups.


Action of drugs on the electrical activity of the red nucleus.


Behavioural and EEG arousal induced by stimulation of unspecific projection systems in a patient with post-traumatic apallic syndrome.


Discriminant analysis in average evoked response studies: the study of single trial data.


Ontogenetic study on development of secondary components of evoked response in rabbit.


Analysis of the ascending activation of evoked potentials in cerebral cortex to stimulation of urinary bladder receptors.


Peculiarities of electrical activity and steady component of cerebral cortex during sleep and wakefulness in infants between 3 and 12 months of age.


Analysis of hypothalamic influences on mono- and polysynaptic potentials of the spinal cord and on the electrocorticogram.


Physiology and pathological physiology of deep structures of human brain (essays).


Changes in blood serotonin titre in rabbits during sustained stimulation of the anterior segments of the hypothalamus with electric current.


Extra- and intracellular investigation of neurone responses in the motor cortex of alert rabbits to acoustic and photic stimuli.


Rhythmical oscillations of electrical activity in the vertebrate brain. I. Rhythmical oscillations of electrical activity in the olfactory analyser of vertebrates.


Concerning the relation between the duration of depression of basic cortical rhythms and the latent period of motor reaction in man.


Changes in electrical and conditioned activity after ablation of the laternal hypothalamus in rabbits.


Influence of the frequency of rhythmic photic stimulation on the harmonic composition of the driving response in the human brain.


Relation of electrical to metabolic evidence of cell excitation.


Electrographic expression of human trace conditioned reflexes to signals of different modalities.


Influence exerted on the electrical activity of the brain by benzactyzine, apzofenum (alpha, alpha-diphenylpropionic acid beta-diethylamino-ethyl ester hydrochloride) and corresponding quinuclidine ethers.


Local prepotential, spreading impulse and closing of the temporary connection.


Trace phenomena in a dominant state.

Trace phenomena in a dominant state.


Development of extinctive inhibition in children in early ontogenesis.


Organization of cortical mechanisms for closing motor conditioned connections.


Modulation of the activity of optic cortex neurons in waking rabbit by different non-visual stimuli.


The effect of calcium and magnesium on dendritic potentials.


Steady potentials of the human brain during alertness, anesthesia and sleep.


Some mechanisms of the rhythmicity of electrical activity of the cerebral cortex.


On neuronal organization of focal epileptiform discharge.


Neurophysiological characteristics of the cortex isolated from subcortical nervous influences.


Unit activity of the neuronally isolated cortex in a chronic experiment.


Propagation of epileptiform activity from neocortex and hippocampus in rabbits and monkeys.


EEG and the declaration of death.

EEG and the declaration of death.


Some aspects of evoked responses to stimulation in cerebral disaster.


Serial electrophysiological studies (EEG, EMG, ERG, evoked responses) in a case of 3 months' survival with flat EEG following cardiac arrest.


EEG studies following resuscitation after cardiac arrest in 60 babies.


EEG findings in dying and resuscitated adult patients.


The effects of hypoxia on the blood pressure and EEG in newborn babies.


Subjective estimates of sleep: an EEG evaluation.


The use of methohexitone in electrocorticography.


Are we Geoffrey Parr's successors?

Are we Geoffrey Parr's successors?


A pseudo-random binary sequence generator: an aid to testing low frequency-wave analysers.


EEG changes in Wilson's disease.

EEG changes in Wilson's disease.


An effect of oral contraceptives on the EEG of normal females.


An electroencephalographic and psychiatric study of 32 insane murderers.


Hormonal influences on mediators of allergic reactions.


The influence of adenosine triphosphate on isolated rat peritoneal mast cells.


Present status of biochemical and pharmacological analysis of secondary cellular damage in antibody-mediated allergic reactions.


Some observations on the molecular mechanisms of immediate-type allergic reactions.


The clinical spectrum and early diagnosis of Dawson's encephalitis, with preliminary notes on treatment.


Intolerance to milk protein.

Intolerance to milk protein.


The viral nucleic acids formed in chick-embryo cells infected with Semliki forest virus.


Paradox of cardiac arrhythmia in anaesthesia.


The albumin-alpha globulin ration in various physiological states in cattle.


Histamine release from human lung by specific antisera.


Immunofluorescent studies of the skin in rosacea.


Modern methods of teaching dentistry.

Modern methods of teaching dentistry.


Cutaneous resorption of heparin and heparinoids investigated by autoradiography.


Comparative pharmacokinetics of coumarin anticoagulants. V. Kinetics of warfarin elimination in the rat, dog, and rhesus monkey compared to man.


Histochemistry of viable frozen-stored human gingiva.


Essential paraproteinaemia.

Essential paraproteinaemia.


Paraproteins.

Paraproteins.


Transient paraproteins.

Transient paraproteins.


Neonatal thyrotoxicosis.

Neonatal thyrotoxicosis.


Pregnancy-associated plasma proteins in trophoblastic disease.


Protein turnover studies in heavy proteinuria.


The iceman changeth. Toward an empirical approach to creativity.


Streamline methods of slide production.

Streamline methods of slide production.


Adaptive mechanisms of young disadvantaged stutterers and nonstutterers.


The bulk reproduction of tapes and slides.


Audio visual teaching in dermatology.

Audio visual teaching in dermatology.


Audio visual teaching in medicine.

Audio visual teaching in medicine.


The Rh factor: past, present, and future.


Clinical observations on malabsorption.

Clinical observations on malabsorption.


Protein synthesis during hibernation. ANL-7535.


Serum protein alterations of 90Sr-fed swine. BNWL-714.


Electrophoretic analysis of spinal fluid on strips of cellogel.


The fine structure of various types of myeloma cells as revealed by electron microscopy.


Lack of binding of complement by IgD.

Lack of binding of complement by IgD.


Nucleoprotein changes in thymocytes after tetanus toxoid stimulation.


Inhibition of DNA synthesis and chromosome aberrations in cultured ehrlich ascites tumor cells following treatment with luteoskyrin.


Mode of action of trichothecin on multiplication of Newcastle disease virus in cultured cells.


Quantitative determination of renal vascular changes related to age and hypertension.


Postmortem changes in endothelial cells of aortic valve homografts.


Cyclophosphamide treatment of mouse systemic lupus erythematosus.


Iron metabolism by reticuloendothelial cells in vitro. Physical and chemical conditions, lipotrope deficiency, and acute inflammation.


Sclerotin in the spore walls of Aspergillus sp.


Histochemical studies on N-acetyl-beta-galactosaminidase in the ovary of sexually mature women.


Histochemical study on mucopolysaccharides in calcium bilirubinate gallstones.


Quantitative determination of immunoglobulins in cerebrospinal fluid.


Cytochemical demonstration of the co-enzyme ubiquinone in normal human blood and bone marrow cells.


A case of IgAK-myelomatosis with two urinary Bence-Jones proteins (BJK and BJL) and multiple chromosomal abnormalities.


Reaction of nervous tissue to application of ionizing radiation.


Immune globulins to Coxiella burneti in man determined by radioisotope precipitation technic.


Alpha-hydroxy fatty acids in hereditary ataxic polyneuritis (Refsum's disease).


Impaired opsonic activity but normal phagocytosis in low-birth-weight infants.


Autoimmunity to the heart in cardiac disease. Current concepts of the relation of autoimmunity to rheumatic fever, postcardiotomyand postinfarction syndromes and cardiomyopathies.


Esophageal substitution.

Esophageal substitution.


Total thyroidectomy in the management of thyrotoxic and euthyroid Graves' disease.


Drug-induced porphyrin biosynthesis. II. Simple procedure for screening drugs for porphyria-inducing activity.


Immunoglobulins and the X-chromosome.

Immunoglobulins and the X-chromosome. Serum levels of immunoglobulins (Ig) G, M, and A were determined in 28 women with an additional X-chromosome (XXX), and in equal numbers of age-matched normal women and men. Mean IgM levels were found to be highest in the XXX group, intermediate in normal women, and lowest in men; these differences were statistically significant. Mean IgM values obtained from seven XXY and three XXXY cases were almost identical with those of normal women and XXX women respectively. No such sex linkage was observed for IgA and IgG levels. These results support the suggestion that the serum level of IgM is related to the number of X chromosomes present.


Effect of pretreatment with carbimazole in patients with thyrotoxicosis subsequently treated with radioactive iodine. Preliminary treatment with carbimazole in a series of 181 patients with thyrotoxicosis selected for treatment with radioactive iodine did not make any significant difference to the subsequent response to (131)I therapy.


The sense of time and history.

The sense of time and history.


Iatrogenic hypothyroid psychosis.

Iatrogenic hypothyroid psychosis.


Cognitive interference by nonverbal symbols in schizophrenics.


Psittacosis in imported parrots, its quick diagnosis by using the Coons technique confirmed by isolation of the causative agent.


Development and study of filler composition of aerosol dispensers for controlling flying insects.


Operating room forum. Follow these steps in missing-sponge cases.


Release of histamine from rat mast cells: a comparison of the effects of 48-80 and two antigen systems.


Cellular mechanisms involved in the release of slow reacting substance of anaphylaxis.


Enzymatic mechanisms in complement-dependent chemotaxis.


Electron microscopy in rapid diagnosis.

Electron microscopy in rapid diagnosis.


Role of complement and leukocytes in immunologic release of vasoactive amines from platelets.


Antagonistic effect of ellagic acid on histamine liberators.


Some cellular functions in acute allergic reactions.


Studies of changes in rum proteins in cows and calves in a herd affected with Johne's disease.


Immunological studies in the cat. Attempts to induce delayed hypersensitivity.


Recent advances in the metabolism and function of vitamin D.


The role of the nurse in renal transplantation.


A special report from the president.

A special report from the president.


Renal transplantation logistics and the operating room nurse.


Progress report on an OR postgraduate program.


Intermittent claudication.

Intermittent claudication.


As I see it: O.R. education.

As I see it: O.R. education.


An overview of audiovisual modes of instruction.


Member in the spotlight. Mary L. Roberts Wilson, R.N.


OR nursing research.

OR nursing research.


The fine structure of Bruch's membrane in the human eye.


Cycloheximide and cortisol inhibiton of estradiol-stimulated uterine uptake and distribution of homologous serum albumin and alpha globulin in the rat.


Effects of estrogens on plasma angiotensinogen and renin activity in nephrectomized rats.


Biomedical communication: a multidisciplinary approach.


The group psychotherapy literature 1968.


Pharmacological characteristics of cyclohexylamine, one of metabolites of cyclamate.


Immunoelectrophoretic and chromatographic demonstration of IgG, IgA, and fragments of gamma-globulin in the human seminal fluid.


Prevention of rhesus disease.

Prevention of rhesus disease.


The Theatre Nursing Education and Research Fellowship Fund.


Training operating theatre attendants.

Training operating theatre attendants.


TB tele-lectures.

TB tele-lectures.


Surgeon's viewpoint--nurse and future.

Surgeon's viewpoint--nurse and future.


Visit to an organ-transplant center. 1. The nurses.


Diagnosis of IgD myeloma.

Diagnosis of IgD myeloma.


IgA and partial deletions of chromosome 18.


Palliation of pain in cancer patients.

Palliation of pain in cancer patients.


Ultrastructural changes in the neural lobe of the hypophysis of the kangaroo rat (Dipodomys merriami) following intraperitoneal injection of hypertonic sodium chloride.


Estrogen: direct effects on hypothalamus or pituitary in relation to pituitary weight changes.


Primary dysmenorrhea: combination vs sequential therapy.


Effect of experimentally induced thyroiditis on biosynthesis of thyroxine in rats.


The influence of iodine in thyroid iodine accumulation and turnover in euthyroid Australian subjects.


Studies on the antithyroid activity of naturally occurring L-5-vinyl-2-thiooxazolidone and its urinary metabolite in rats.


The post-extrasystolic T wave change: a correlate of the inotropic state.


Intra-atrial tele-electrocardiography.

Intra-atrial tele-electrocardiography.


Myocardial pathology following scorpion venom injection.


Immunologic deficiency in the congenital rubella syndrome.


Brain hexokinase: immunohistochemical localization at the light microscopic level.


Specific dissociation of bacteriophage f2 protein to an 11S component.


Selective reduction and mercuration of cystine IV-V in bovine pancreatic ribonuclease.


Thiolation for labeling of proteins, using catalysis by silver and imidazole combined.


A biochemic test for differential diagnosis between acanthocytosis and spino-cerebellar degenerations.


Herdopathia atactica polyneuritiformis (Refsum's disease). The diagnostic value of phytamic acid determination in serum lipids.


Lysogeny among mycobacteria.

Lysogeny among mycobacteria.


Number of gammaglobulin containing cells after the single local administration of antigen.


Isolation and characterisation of immunoglobulins in the serum of precolostral piglets.


The National Library of Medicine and medical education.


The relationship between amino acid incorporation and cardiac work level in the rat heart-lung preparation.


Abnormal cerebrospinal fluid total protein and gamma-blobulin levels in 256 patients admitted to a psychiatric unit.


Familial goiter with dimished synthesis of thyroglobulin.


Hereditary chronic polyneuropathy. Electrophysiological and pathological studies in an affected family.


A spastic paraplegic syndrome in South India.


Demonstration of pathogenic fungi in formalin-fixed tissues by immunofluorescence.


Proliferation of immunologically active cells in the intestines of primates during secondary response to cholera toxin.


Treatment of Dawson's encephalitis wit5-bromo-2'-deoxyuridine. Double-blind study.


Fluorescent protein-dye conjugates. II. Gamma globulin conjugated with various dyes.


Changes of evoked potential duration in the course of defensive conditioning in dogs.


Instant electrocardiograms as a teaching aid.


Increased ratio of glycine- to taurine-conjugated bile salts in patients with ileal disorders.


An evaluation of serologic and antimicrobial therapy in the treatment of tetanus in the United States.


An immunolical explanation for the starry sky histological pattn of a malignant lymphoma.


An outbreak of gastroenteritis associated with ingestion of raw clams.


Diverticular disease of the colon--a disease of the century.


Clonidine.

Clonidine.


Reticuloendothelial blockade and A.L.S.

Reticuloendothelial blockade and A.L.S.


Hugh Barber M.D. Lond., F.R.C.P.

Hugh Barber M.D. Lond., F.R.C.P.


Peter Owen Martin McGirr M.D. Sheff., D.P.H., D.I.H.


Effect of clopamide and hydrochlorothiazide on plasma ammonia.


Prognosis in the irritable-bowel syndrome. A prospective study.


Fasting serum triglyceride, cholesterol, and lipoprotein levels during oral-contraceptive therapy.


Some effects of oral contraceptives on carbohydrate metabolism.


Relationship of infecting urinary organism to the faecal flora in patients with symptomatic urinary infection.


Vitamin-B12 deficiency and diabetic neuropathy.


Method for estimating individual drug-dosage regimens. An application of the occupancy principle.


Arterial blood gases after atropine sulphate in healthy volunteers.


Recovery of resistance (R) factors from a drug-free community.


Evidence for reduction and methylation of folate in the intestine during normal absorption.


Lack of inhibition of hepatic cholesterol synthesis by dietary cholesterol in cases of familial hypercholesterolaemia.


Postoperative elevation of the hand.

Postoperative elevation of the hand.


Device for removing head of femur.

Device for removing head of femur.


Metabolic effects of oral contraceptives.


National intelligence.

National intelligence.


A shifting curve.

A shifting curve.


Osteotomy of the upper tibia.

Osteotomy of the upper tibia.


Northwick Park.

Northwick Park.


A little more about CS.

A little more about CS.


Accidents at work.

Accidents at work.


Liaison between phsicians and psychiatrists in a teaching hospital.


Should a consultant post be permanent?

Should a consultant post be permanent?


Dispensing in the country.

Dispensing in the country.


Polioantibody titres in children aged 7-15 years in London.


Disorders of brain and connective tissue in a patient with 47,XYY karyotype.


Failure of transmission of the extra chromosome in subjects with 47,XYY karyotype.


Magnesium and the haemodialysis patient.


Blood-groups and serum lipids and phosphatases.


Turista.

Turista.


Asthma mortality and pressurised aerosols.


Subdural haematoma and anticoagulant treatment.


Mycobacteria, skins, and needles.

Mycobacteria, skins, and needles.


Effect of phenobarbitone and pre-eclamptic toxaemia on neonatal jaundice.


Treatment of tetanus.

Treatment of tetanus.


Ischaemic heart-disease complicating nephrotic syndrome.


IgA immunoglobulins and autoimmunity.

IgA immunoglobulins and autoimmunity.


Five gangliosidoses.

Five gangliosidoses.


Rectal perforation by thermometer.

Rectal perforation by thermometer.


Repeated abortions in XO-XX mosaicism.

Repeated abortions in XO-XX mosaicism.


Day care for geriatric patients.

Day care for geriatric patients.


Dermatoglyphics in leukaemia.

Dermatoglyphics in leukaemia.


Renal production of agiotensin II.

Renal production of agiotensin II.


Bernard Leo Salmon Murtagh, M.B. Birm., F.F.A. R.C.S.


Discovery of the LE cell and its morphology.


Immunologic factors in lupus erythematosus cell formation.


Diagnostic aspects of lupus erythematosus cells and antinuclear factors in disease states.


Induction of lupus erythematosus in the skin.


Mechanism and dynamics of closed head injuries (preliminary report).


Amyloid in late postirradiation necrosis of brain.


Soluble proteins in normal and diseased human brains.


An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response.


Treatment of lymphopenic hypogammaglobulinemia and bone-marrow aplasia by transplantation of allogeneic marrow. Crucial role of histocompatiility matching.


Behaviour of mouse mast cells during anaphylaxis in vitro.


The effect of 19S alpha-2 globulin from human serum on the hemoglobin content of bone marrow of rradiated mice.


Stimulation of thymic and bone marrow regeneration in irradiated mice by protein fractions of human serum and sheep spleen.


Metabolism of immunoglobulins.

Metabolism of immunoglobulins.


Antithrombin 3. Protection against death after injection of thromboplastin. Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.


Effects of phenethyl alcohol on toxinogenic Staphylococcus aureus.


The significance of hyaline necrosis in liver biopsies.


Influence of Plasmodium berghei yoelii or P. chabaudi or both on the course of splenomegaly and immunoglobulins in mice.


A simple test for measuring platelet aggregation. Results in von Willebrand's disease and uraemia.


Fluorescent antibody levels in mice infected with Plasmodium vinckei and P. chabaudi.


Acid mucopolysaccharide localization in intestinal absorptive cells after irradiation. BNWL-714.


Some considerations on cultured chorionic cells from the human placenta by means of steroid enzymes and an electron microscope.


A method for immediate visualization of proteins in acrylamide gels and its use for preparation of antibodies to enzymes.


Determination of human serum lipoprotein patterns by agarose gel electrophoresis.


Pyridoxine chemistry. XXI. Thin-layer chromatography and thin-layer electrophoresis of compounds in the vitamin B6 group.


Complement immunofluorescent staining in bullous pemphigoid.


Antibodies against folic acid. I. In vitro biophysical effect.


Starch gel electrophoretic examination of serum proteins, with special reference to some gamma globulins not previously described.


Some observations on the developmental histology of the human foetal uterus.


Observations on the mechanisms of development of congenital anomalies in the rat produced by anti-rat kidney sera.


A case of circumscribed myosarcoma of the prostate.


Gamma globulin studies of biospy material and serum in solitary plasmacytoma of the spine.


Recovery of thyroid hormone biosynthesis after a single injection of methylthiouracil as judged by thyroidal radioiodine uptake, thyroidal protein-bound iodine, thyroidal radioiodinated amino acids and thyroglobulin in the rat.


Experimental autologous immune-complex nephritis: an electron microscope and immunohistochemical study.


A histochemical study of lysosomal enzymes in the retina of the rat.


Fixation of proteins by osmium tetroxide, potassium dichromate and potassium permanganate. Model experiments with bovine serum albumin and bovine gamma-globulin.


An inhibitor of reovirus in sheep serum.


Load-consequent changes in the microstructure of human skin.


The action of chlormadinone acetate (6-chloro-delta6-dehydro-17alpha-acetoxyprogesterone) upon experimentally induced ovulation in the rabbit. 1. The ovulation response to electrical stimulation of the median eminence, or to the intrapituitary infusion of median eminence extract, was observed in control rabbits and animals pre-treated with chlormadinone acetate.2. Chlormadinone acetate pre-treatment did not significantly reduce the proportion of rabbits ovulating in response to electrical stimulation. However, there was a significant reduction in the average number of ruptured follicles when compared with the animals in the control group.3. Chlormadinone acetate pre-treatment significantly reduced the proportion of animals ovulating in response to the intrapituitary infusion of median eminence extract as compared with the control series. However, there was no significant reduction in the average number of ruptured follicles (in those rabbits that ovulated) when compared with the control groups.4. Chlormadinone acetate pre-treatment produced no significant effect upon either the proportion of animals ovulating, or the average number of ruptured follicles, following I.V. injection of 50 mug LH.5. The conclusion drawn is that chlormadinone acetate blocks copulattion-induced ovulation in the rabbit by action at a site in the central nervous system located above the median eminence. The possible effects of chlormadinone acetate upon the secretion of FSH, the pituitary sensitivity to releasing factors and the ovarian sensitivity to LH are discussed.


Prevention of anaphylactoid reaction by glucocorticoid and endotoxin-conditioning.


Properties of a small virus associated with infectious canine hepatitis virus.


Pituitary enlargement with longstanding myxoedema.


Lobular carcinoma of the breast an ultrastructural comparison with certain duct carcinomas and benign lesions.


Glycogen changes with age in oral epithelia of the rat.


Otitis media and its complications (1967 and 1968).


Audio visual aids in medical education.

Audio visual aids in medical education.


The high-risk infant. Implications in adoption.


Ultrastructure of eosinophilic staining epidermal cells in toxic epidermal necrolysis and fixed drug eruption.


Eosinol counterstain for routine paraffin embedded tissue.


A modified phosphotungstic acid haematoxylin stain for formalin-fixed tissues.


A scheme for the detection of patients requiring treatment with anti-D gamma-globulin.


Cytochemical observations on the adenovirus type-12-transformed hamster-embryo cell cultures.


Effect of bilateral nephrectomy on transfusion requirements of patients undergoing chronic dialysis.


Antibody production in immunosuppressed recipients of renal allografts.


Mycoplasma pneumoniae as a determinant of the Guillain-Barré syndrome.


Pyarthrosis complicating rheumatoid arthritis.


Unusual host-parasite relationship in blood-donors responsible for transfusion-induced falciparum malaria.


Effect of dipyridamole on the incidence of clinically detectable deep-vein thrombosis.


Hereditary factors in pernicious anaemia and their relation to serum-immunoglobulin levels and age at diagnosis.


Depression of interferon production in mice after treatment with anti-lymphocyte serum.


A double-balloon ureteric-stone extractor.


Care of the mentally subnormal.

Care of the mentally subnormal.


Should a board tell?

Should a board tell?


The Hodgkin maze.

The Hodgkin maze.


In hospital or at home?

In hospital or at home?


Suicide and the press.

Suicide and the press.


Examination of water-supplies.

Examination of water-supplies.


Interface of protein nutrition and medicine in the tropics.


Salmonella dublin skin lesions in a veterinary surgeon.


Are subnormality hospitals an anachronism?


A hypotensive episode caused by amitriptyline?


Catecholamine hyperpnoea.

Catecholamine hyperpnoea.


L-dopa for progressive supranuclear palsy.


Oral contraceptives and blood-iron.

Oral contraceptives and blood-iron.


Bilateral rupture of the patellar ligaments in systemic lupus erythematosus.


Colchicine and chromosome aberrations.

Colchicine and chromosome aberrations.


Practical and theoretical implications of fetal-maternal lymphocyte transfer.


Hepatitis in a haemodialysis unit.

Hepatitis in a haemodialysis unit.


Epimembranous nephropathy.

Epimembranous nephropathy.


Combination of penicillin and metronidazole.


The effect of neuraminidase on lymphocyte cultures.


Lymphocytotherapy for pseudomonas infections, tuberculosis, and leprosy.


L-asparaginase and blastogenesis.

L-asparaginase and blastogenesis.


Evan Jones.

Evan Jones.


Frederick Hugh Young.

Frederick Hugh Young.


Genetically controlled variations in the Bence-Jones proteins and their implications to the three-dimensional structure of immunoglobulins. ANL-7535.


Plasma urate levels in mongolism.

Plasma urate levels in mongolism.


Variable patterns of immunoglobulin and complement deposition in the kidneys of patients with systemic lupus erythematosus.


Proliferative glomerulonephritis in children. A correlation of varied clinical and pathologic patterns utilizing light, immunofluorescence, and electron microscopy.


Immunoglobulin E in dermatoses. Levels in atopic dermatitis and urticaria.


Elastotic nodules of the antihelix.

Elastotic nodules of the antihelix.


Hidroacanthoma simplex. A report of two cases.


Studies on the localization of rat liver mitochondrial 5'-endonuclease.


Origin of the pericellular baskets of the pyramidal cells of the human motor cortex: a Golgi study.


Non-synaptic ring images in silver-impregnated lateral geniculate nucleus.


The relationship of supravital staining of the corneal endothelium to the temperature-reversal effect.


Optic atrophy following herpes zoster ophthalmicus in a child.


Supravital staining of the corneal endothelium and evidence for a membrane on its surface.


Infectious mononucleosis: current status of candidate virus.


Controlled clinical studies of orally administered antiemetic drugs.


Isolation of synaptic complexes in a caesium chloride density gradient: electron microscopic and immunohistochemical studies.


Evidence for RNA transport in rat optic nerve.


Axoplasmic transport in the optic nerve and tract of the rabbit: a biochemical and radioautographic study.


Fast and slow phases of axoplasmic flow in ventral root nerve fibres.


Cancer of the colon and rectum--general aspects, diagnosis, treatment, and prognosis. A review.


Comparison of the behaviour of a soluble and a membrane-bound enzyme in transected peripheral nerves.


The ultrastructure of the epidermis in lichen ruber planus as revealed by electron microscopy. II. Cytoplasm and nucleus in certain basal and spinous cells.


Acid mucopolysaccharides closely associated with collagen fibrils in normal human synovium.


A fine structure study on spermiogenesis in the Arachnida, Leiobunum sp. (Phalangida; Harvestmen).


Effects of a sequential oral contraceptive on endocervical corbohydrate histochemistry.


Radiation therapy of carcinoma of the cervical stump.


Electrophoretic patterns of serum proteins in leprosy.


Experimental cardiac anaphylaxis. Physiologic, pharmacologic and biochemical aspects of immune reactions in the isolated heart.


Aspects of a computer-assisted system for calling blood donors from a specialized panel.


Metabolism of small molecular weight monodisperse nuclear RNA.


Prevention of Rh-sensitization by anti-D immunoglobulin. Report of the 3rd meeting of the study group at Freiburg on 27-28 January 1968. II.


A clinical trial of alpha-6-deoxyoxytetracycline (doxycycline) in the treatment of urinary tract infections.


Investigation into a modification of the biphasic 131-I test.


Current status of tetanus prophylaxis.

Current status of tetanus prophylaxis.


A periodic acid-silver methenamine restaining method for cryostat sections of renal tissue previously used in the immunofluorescence technique.


New colored maleimides for the demonstration of bound sulfhydryl.


Electron microscopic demonstration of adenosine triphosphate phosphohydrolase activity in herring gull salt glands.


An immunoglobulin-enzyme bridge method for localizing tissue antigens.


Light microscopic study of the peroxidatic activity of catalase in formaldehyde-fixed rat liver.


Changes in enzyme activities of various muscle fiber types in rat induced by different exercises.


Changing nuclear histone patterns during development. 3. The deoxyribonucleic acid content of spermatogenic cells in the crab Emerita analoga.


Lead ion and phosphatase histochemistry. 3. The effects of lead and adenosine triphosphate concentration on the incorporation of phosphate into fixed tissue.


Cytochemical evidence for the existence of peroxisomes in Botrytis cinerea.


Iodine and persulfate as histochemical blocking agents for tyrosine and tryptophan residues in human gingiva.


Histochemical demonstration of 5-hydroxytryptamin in a malignant carcinoid of the small intestine.


Non-neoplastic surface epithelium continuous with invasive cervical carcinoma.


Synthes of alpha-2 (acute phase) globulin by fetal and neonatal rat liver in vitro.


Immunosuppressive treatment of nephrotic syndrome.


Selective anticoagulant therapy in connexion with prostatectomy.


Cancer palliation by solid tumor chemotherapy. 3.


Clinicopathologic conference. Multiple endocrine adenomatosis.


Microbial transformations of peptide antibiotics. IV. Inducers of actinomycin and dihydrostaphylomycin S enzymes in Actinoplanes missouriensis.


The production, preparation, testing and use of antilymphocyte globulin.


Fluorescence depolarization. 3. Selective excitation of contributions from thermally induced intramolecular displacements.


Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions.


Immunoglobulins and the X-chromosome.

Immunoglobulins and the X-chromosome.


Rhesus sensitization and abortion.

Rhesus sensitization and abortion.


Passive immunization against chicken-pox.


Operating room. Procedure for renal homotransplant.


RNA metabolism in mammalian cells at elevated temperature.


Visual display board improves OR scheduling.


In vitro epiphyseal-plate growth in various oxygen tensions.


Response of simian virus 40-transformed cell lines and cell hybrids to superinfection with simian virus 40 and its deoxyribonucleic acid. Whereas normal human and monkey cells were susceptible both to intact simian virus 40 (SV40) and to SV40 deoxyribonucleic acid (DNA), human and monkey cells transformed by SV40 were incapable of producing infectious virus after exposure to SV40, but displayed susceptibility to SV40 DNA. On the other hand, mouse and hamster cells, either normal or SV40-transformed, were resistant both to the virus and to SV40 DNA. Hybrids between permissive and nonpermissive parental cells revealed a complex response: whereas most hybrids tested were resistant, three of them produced a small amount of infectious virus upon challenge with SV40 DNA. All were resistant to whole virus challenge. The persistence of infectious SV40 DNA in permissive and nonpermissive cells up to 96 hr after infection was ascertained by cell fusion. The decay kinetics proved to be quite different in permissive and nonpermissive cells. Adsorption of SV40 varied widely among the different cell lines. Very low adsorption of SV40 was detected in nonsusceptible cells with the exception of the mKS-BU100 cell line. A strong increase in SV40 adsorption was produced by pretreating cells with polyoma virus. In spite of this increased adsorption, the resistance displayed by SV40-transformed cells to superinfection with the virus was maintained.


Reaction of chick embryo cells infected with leukosis strain MC29 virus with fluorescein-labeled antibody. Immune serum was prepared in the rabbit with BAI strain A leukosis virus isolated by centrifugal fractionation from the plasma of chickens with myeloblastic leukemia and further purified on a potassium tartrate gradient. Antibody to group-specific antigen was demonstrated in the serum by immunoelectrophoresis and immunodiffusion. Fluorescein-conjugated serum was used unabsorbed and absorbed with chick cells for study of acetone-fixed chick embryo cells uninfected or infected with strain MC29 avian leukosis virus. With unabsorbed serum, large numbers of cytoplasmic particles stained in a few cells within 2 hr after exposure to virus, and the cell number increased greatly in 24 hr. Absorption of the serum abolished the early reaction. Staining with absorbed serum was delayed until about 14 hr after culture exposure to virus, but essentially all cells were stained within 72 hr at the time when all cells were morphologically altered. Differences between the responses to unabsorbed and absorbed serum suggested cytoplasmic formation or concentration of chick tissue antigen similar to that incorporated in leukosis virus particles. The characteristics of staining with absorbed serum were similar to those observed by others in analogous studies with avian tumor viruses.


Studies on the nucleocapsid structure of a group A arbovirus. When Sindbis virus (273S) was treated with sodium desoxycholate, a nonhemagglutinating 136S particle was liberated from the virion, representing the viral nucleocapsid (core). Electron microscopically it appeared as a spherical particle 35 nm in diameter, showing ringlike morphological units 12 to 14 nm in diameter on its surface. When the one- and two-sided images of core particles were correlated, their structure could be demonstrated to have the T = 3 arrangement of 32 hexamer-pentamer morphological units within a symmetrical surface lattice. The core contained a further spherical structure (12 to 16 nm in diameter) which was designated as the central core component. Two proteins were found associated with the core, a third viral protein belonged to the hemagglutinating surface structures. The significance of these findings for virus classification is discussed.


Tomorrow's community physician.

Tomorrow's community physician.


Early pituitary implantation with yttrium-90 for advanced breast cancer.


Phaeochromocytoma: a persistent diagnostic problem.


The vanishing testis.

The vanishing testis.


Buccal sex-chromatin and breast cancer.

Buccal sex-chromatin and breast cancer.


Depression of contractility in rat heart muscle by free fatty acids during hypoxia.


Increased susceptibility of males to infection.


The community paediatrician.

The community paediatrician.


Specialist registration.

Specialist registration.


Vascular factors in acute pancreatitis.

Vascular factors in acute pancreatitis.


Routine medical examinations.

Routine medical examinations.


Meat for the dog.

Meat for the dog.


Hernia and intestinal injury.

Hernia and intestinal injury.


Treatment of salmonella enteritis.

Treatment of salmonella enteritis.


Computer-based screening system for patients at risk of hypothyroidism.


Acid mucopolysaccharides in cultured human fibroblasts.


After the Royal Commission. A visitor's impressions.


Diphosphonates in the treatment of myositis ossificans.


Pseudomyxoma peritonei.

Pseudomyxoma peritonei.


Hydroxyurea in the treatment of refractory psoriasis.


Oral contraceptives and blood-iron.

Oral contraceptives and blood-iron.


Nuclear immunofluorescence: a guide to treatment in S.L.E.


The guaiacum test for occult blood in faeces.


Diverticular disease of the colon.

Diverticular disease of the colon.


Teratogenicity of lithium in mice.

Teratogenicity of lithium in mice.


Prevention of the post-transfusion syndrome.


Effect of nephrectomy on transfusion requirements of dialysis patients.


Inheritance of chronic granulomatous disease.


Treatment of hypertriglyceridaemia.

Treatment of hypertriglyceridaemia.


Symptomatic relief by hypnotic treatment.


Parchment-skin palms.

Parchment-skin palms.


Penetration of a beta-amanitin-rabbit-albumin conjugate into hepatic parenchymal cells.


Chondroitin-4-sulphate mucopolysaccharidosis--a new variant of Hurler's syndrome.


Aetiology of coeliac disease.

Aetiology of coeliac disease.


Frederic Charles Bartlett Kt., C.B.E., M. A. Cantab., F.R.S.


Androgenic induction of alpha-2-u-globulin in the rat: requirement of an intact pituitary.


Microradiographic study of the arterial circulation of the brain.


Symposium on care of the gravely ill surgical patient. The critically ill patient.


Dermo-epidermal junction in invasive squamous cell carcinoma. An electron microscopic study.


The water-binding properties of the water-soluble substances in the horny layer.


Proteolytic enzymes in the skin. II. A comparative study of skin homogenates of five mammalian species.


Influence of solvents and surface active agents on the barrier function of the skin towards Sarin. 3. Restoration of the barrier function.


Percutaneous absorption of Soman and Tabun, two organophosphorus cholinesterase inhibitors.


Hydrolysis of Soman and Tabun (two organophosphorus cholinesterase inhibitors) in cutaneous tissues.


Alcohol dermatitis.

Alcohol dermatitis.


Maibach HI: Sensitizing capacity of usnic acid derived from lichenized fungi.


Sensitizing properties of p-amino-diphenylamine.


Delayed reactivity to bacterial and viral extracts in the aged.


Adrenocortical suppression with small doses of topical corticosteroids.


Long term prognosis of chronic paronychia.


Anticomplementary reactions and their relation to some auto-immune phenomena in syphilitic infection.


Quantitative studies on cortisol-induced decay of lymphoid cells in the thymolymphatic system.


Total and half body irradiation. Effect on cognitive and emotional processes.


Developmental and clinical correlates of cerebral dysrythmia.


Measurements of protein leakage in the acute and recovery stages of a thermal injury.


Communications--a supplement to medical library service. The University of Wisconsin Medical Center and University Extension established a Medical Communications Center in the Medical Library of the University in September of 1967. THE OBJECTIVES OF THE MEDICAL COMMUNICATIONS CENTER WERE: [List: see text]


Home programming by occupational therapy: an approach to the habilitation and rehabilitation of atypical development in children.


Improvement of microscopic observation of insufficiently stained specimens by using an amplitude-contrast device.


Stained smear in amoebiasis.

Stained smear in amoebiasis.


The effect of alternating prednisone therapy on insulin binding.


Evaluation of diagnostic methods in amoebiasis.


Structural changes in Escherichia coli infected with a phi X174 type bacteriophage.


A persistent and inapparent infection of L cells with the virus of lymphocytic choriomeningitis.


Thyroid-stimulating hormone and thyroxine levels in the plasma of patients with Down's syndrome.


Investigation of proteinuria associated with hypertension in pregnancy.


Pathologist in prognosis of human breast cancer.


Whipple's operation in a man of 25 years; prizewinning nursing care study.


Editorial: Seven faults of scientific sessions.


Primary malignant melanoma of the oral cavity. Report of a case.


Immunochemistry of IgE.

Immunochemistry of IgE.


The mechanism of histamine release from isolated rat peritoneal mast cells induced by d-tubocurarine.


Detecting IgE antibody (reagin) by the red cell linked-antigen antiglobulin reaction.


Te function of the caudate nucleus in the control of some paroxystic activities in the neuraxis.


Effect of various salts on the activity of enzymes implicated in amino-acid metabolism.


Vagal inhibition of frog's heart perfused with sucrose solution.


Investigation of the fatty acid composition of the snail "Arianta arbustorum".


Synthesis of macromolecules in epithelial cells of the cultured amphibian lens. IV. Requirement of DNA replication for the synthesis of RNA and protein during the "G2" period of the cell cycle.


The regional localization of arylamidase activity in bovine brain.


Interaction between isolated amphibian skin and insulin.


Insulin and glucagon secretion by isolated islets of Langerhans.


The effects of repetitive activation on single motor unit potentials.


Aggregation-dissociation equilibria of the hen's egg-white ribonuclease.


Selective extraction of polypeptides from poliovirus by concentrated urea.


Negative result: treatment of patients with rheumatoid arthritis with gamma globulin: a double-blind controlled study.


The present status of antinuclear antibody serology.


Cellular proliferation on the vitreous surface after photocoagulation.


A comparison of chloroplast membrane surfaces visualized by freeze-etch and negative staining techniques; and ultrastructural characterization of membrane fractions obtained from digitonin-treated spinach chloroplasts. Spinach chloroplast lamellae were washed free of negatively staining surface particles (carboxydismutase and coupling factor protein) and the resulting smooth-surfaced lamellae still showed the usual large (175 A) and small (110 A) particles seen by freeze-etching. Therefore, the freeze-fracture plane probably occurs along an internal surface of the chloroplast membrane. Fractions obtained by differential centrifugation of digitonin-treated chloroplast membranes were studied by negative staining, thin sectioning, and freeze-etching techniques for electron microscopy. The material sedimenting between 1,000 g and 10,000 g, enriched in photosystem II activity, was shown to consist of membrane fragments. These freeze-etched membrane fragments were found to have large particles on most of the exposed fracture faces. The large particles had the same size and distribution pattern as the 175 A particles seen in intact chloroplast membranes. The material sedimenting between 50,000 g and 144,000 g, which had only photosystem I activity, was found to consist of particles in various degrees of aggregation. Freeze-etching of this fraction revealed only small particles corresponding to the 110 A particles seen in intact chloroplasts. A model is presented suggesting that chloroplast lamellar membranes have a binary structure, which digitonin splits into two components. The two membrane fragments have different structures, revealed by freeze-etching, and different photochemical and biochemical functions.


Uptake  peroxidase into the smooth-surfaced tubular system of the gastric acid-secreting cell.


Electron microscope analysis of young and old red blood cells stained with colloidal iron for surface charge evaluation. Human and rabbit red blood cells, separated into "young" and "old" age groups by differential flotation on phthalate esters, were fixed with glutaraldehyde and labeled with colloidal ferric oxide. Electron micrographs of thin sections of young cells showed a uniform and dense depostion of positive iron particles. Old cells showed particles deposited irregularly, leaving unlabeled gaps on the membrane surface. Red cells incubated with 10 units/ml receptor-destroying enzyme (RDE) demonstrate a reduced labeling, similar to that of old cells. After neuraminic acid had been removed from red cells by 20 units/ml RDE, no iron particles were found on membrane surfaces. The different labeling of young, old, and RDE-treated human and rabbit red cells was correlated with their electric mobility and agglutinability by poly-L-lysine. The contradiction between the apparent similarity in charge density of human and rabbit red cells as estimated by density of iron particles and the markedly lower electric mobility of rabbit red cells is discussed.


Isolation and characterization of chromatin from Neurospora crassa. Different preparations of chromatin isolated from mycelia of Neurospora crassa were analyzed for DNA-associated RNA and proteins. The UV absorption spectra, the ultrastructure of chromatin, and the amino acid composition of the acid-extractable proteins were studied. The protein:DNA ratios range from 1.5 to 2.8; the RNA:DNA ratios range from 0.5 to 1.24. UV absorption shows a macimum at 259 mmicro and a minimum at 238-239 mmicro. The E280/E260 ranges from 0.59 to 0.70. Electron microscopy reveals a fibrous structure with individual fibers of 120-150 A average diameter. Attempts were made to study the protein by polyacrylamide gel electrophoresis and amino acid analysis. The results indicate that Neurospora chromatin does not contain basic proteins comparable to calf thymus histone. The ratios of basic to acidic amino acids range from 0.93 to 1.19. On electrophoresis, no bands are seen whose positions correspond to those of histones. Staining for basic proteins with fast green or eosin Y at pH 8.2 also shows a negative reaction, suggesting the absence of histones.


Osmium zinc iodide reactive sites in the epidermal Langerhans cell. Fixation of epidermis with a mixture of osmium tetroxide and zinc iodide (OsO(4)-ZnI(2)) for 24 hr renders the central periodic lamella of the Langerhans cell granule (LCG), the Golgi region, and the nuclear envelope of epidermal Langerhans cells preferentially visible. The use of this technique on Langerhans cells in normal epidermis and in epidermis of patients with histiocytosis (Letterer-Siwe disease) allows a broader visualization of the LCG's than was heretofore possible with routine glutaraldehyde-osmium tetroxide fixation and uranyl acetate-lead staining. The identical staining of Golgi apparatus and LCG favors the view that there is close relation between the Golgi area and the LCG's. Different staining characteristics of the LCG's near the Golgi region and at the cell periphery, respectively, may suggest that the LCG undergoes changes on its way from the Golgi area towards the extracellular space. The hypothesis is advanced that the material which is heavily impregnated with metal after fixation with OsO(4)-ZnI(2) might be a lipid.


Reduction in surface charge as an explanation of the recognition by macrophages of nuclei expelled from normoblasts. The density and distribution of electric charge on the surface of rabbit bone marrow cells was visualized by electron microscopy after the cell surfaces had been stained with charged colloidal iron particles. Expulsed erythroid nuclei are less negatively charged than any other cell in the bone marrow. They carry from about one-half to one-third of the charge density on the remaining future reticulocyte. The reduction in the surface charge density is already apparent when the nucleus is partially expulsed. Practically no positive charge was found on its surface or on the surface of any other bone marrow cell. The possibility that the reduced negative charge on the surface of expelled erythroid nuclei is one of the means by which the macrophage distinguishes it from other bone marrow cells is discussed.


The physiology of immunity.

The physiology of immunity.


The influence of specific chemical factors in the solvent on the absorption of macromolecular substances from the small intestine of the new-born calf. 1. The absorption, without change, of [(131)I] and [(125)I]solutes of high molecular weight after duodenal infusion has been measured in anaesthetized calves less than 20 hr old by analysis of lymph collected from the thoracic or intestinal duct.2. Factors present in boiled bovine colostrum whey known to be necessary for the rapid absorption of [(131)I]bovine serum gamma-globulin have now been shown to accelerate the passage of [(131)I]polyvinyl pyrrolidone (PVP) of mean mol. wt. 160,000 (K.60) into the lymph in a comparable manner.3. [(131)I]PVP K.30 (mean mol. wt. 40,000) and [(131)I]human serum albumin could be absorbed to some degree in the absence of solvent factors necessary for the absorption of solutes of higher mol. wt. and a large proportion of the solute thus absorbed passed directly into the portal capillaries.4. Lactate and pyruvate and salts of certain lower volatile fatty acids resemble factors in colostrum whey in their facilitation of the absorption of both gamma-globulin and PVP K.60: these active compounds were not however found in colostrum in significant quantities.5. Potassium isobutyrate was the most effective of the compounds tested and at concentrations of 56.7 m-mole/l. generally accelerated absorption to a greater degree than did colostrum whey itself.6. Absorption of both gamma-globulin and PVP K.60 from colostrum whey was characterized by a profuse flow of lymph containing relatively low concentrations of labelled solute. In contrast, when these solutes were fed in solutions containing simple compounds such as potassium isobutyrate they appeared in very high concentrations in the lymph, the flow of which remained relatively scant.7. When [(125)I]PVP was administered in water, little was absorbed. If, however, such an infusion was followed 3 hr later by a duodenal infusion of colostrum, [(125)I]PVP passed into the lymph almost immediately. This response was too rapid for the colostrum to have reached the absorbing cells in the terminal ileum.8. Intravenous infusions of L+lactate have been found to facilitate the absorption of [(125)I]PVP K.60 introduced into the duodenum in water. This indicates that some of the solvent factors which accelerate absorption may reach the terminal ileum via the blood vascular system after they themselves have been absorbed from the upper small intestine.


Limitations of metachromasia as a diagnostic aid in pediatrics.


Effects of semen collection and storage temperates on sperm viability ad fertility in turkeys.


A staining technique for spleen nofules. A comparison od Do's.


Diagnostic limitations of metachromasia.


Primary treatment of patients with resectable breast carcinoma.


Use and abuse of gamma globulin.

Use and abuse of gamma globulin.


Sequential approach to oral contraceptive therapy.


The timing of DNA synthesis in Amoeb  proteus.


A-V aids speak up in your office.

A-V aids speak up in your office.


Immunoglobulins.

Immunoglobulins.


Detection of Chlamydia (Bedsonia) in certain infections of man. I. Laboratory procedures: comparison of yolk sac and cell culture for detection and isolation.


Immunological localization of chromogranins in sheep sympathetic neurones, and their release by nerve impulses.


Helping the clumsy child in school.

Helping the clumsy child in school.


Glycoproteins: their biochemistry, biology and role in human disease (first of two parts).


Breaking communication barriers.

Breaking communication barriers.


Urinary C19 and C21 steroid patterns in iosexual precocious puberty during long-term treatment with gestagens.


A familial 3-18 reciprocal translocation resulting in chromosome duplication-deficiency (3?plus-18q minus).


Psychosis due to acute hypothyroidism during the administration of carbimazole.


Antibodies of the IgA type in intestinal plasma cells of germfree mice after oral or parenteral immunization with ferritin. In adult germfree C(3)H mice immunized with horse spleen ferritin, either subcutaneously or intraperitoneally, plasma cells containing specific antibodies were found in lymph nodes and spleen and, in smaller numbers, also in the lamina propria of the intestine. In extraintestinal sites, these antiferritin-containing plasma cells were mainly of the IgM class after a single stimulation, and of the IgG(1) class after repeated stimulation. In the intestine, all the anti-ferritin-containing cells appeared to be of the IgA class. Circulating antibodies, after repeated stimulation, were for the major part IgG(1) and IgG(2). In germfree mice given ferritin in their drinking water, antiferritin-containing cells were abundant in the intestinal mucosa, much less numerous in the mesenteric lymph nodes, and extremely scarce in other lymphoid tissues. All these cells, whatever their location, appeared to belong exclusively to the IgA class. Similarly, all the circulating antibody in these animals was found to be IgA. These findings illustrate the role of the gut as a site of antibody synthesis, as well as its selective commitment to the production of antibodies of the IgA class.


Studies on antigenic competition.

Studies on antigenic competition. Antigenic competition was studied in a haptenic system. It was found that: (a) The extent of competition is greater when larger doses of antigen are employed. (b) Antigenic competition appears to be independent of the carrier molecule. (c) The affinity of the antibody produced in antigenic competition is approximately equal to the affinity of antibody formed by animals immunized with only one antigen. (d) Antigenic competition only occurs when both antigens are injected so as to drain into the same regional lymph nodes. The results suggest that antigenic competition occurs locally at the site of antigen stimulation and is not mediated by a circulating factor, by tolerance induction, or by suppression due to synthesis of cross-reacting antibodies.


Heavy and light chain allotypic markers on rabbit homocytotropic antibody. Evidence has been presented that rabbit homocytotropic antibody prepared against ovalbumin bears allotypic markers of both group a (heavy chain) and group b (light chain). This was shown by specific removal of activity in passive cutaneous anaphylaxis assays by anti-allotype immunoadsorbents. The homocytotropic antibody has properties which indicate that it belongs to a new class of rabbit immunoglobulin. These results demonstrate that this newly described class possesses the allotypes of both groups a and b, as has been previously shown for other rabbit immunoglobulin classes.


Polyribosomes of Escherichia coli. II. Experiments to determine the in vivo distribution of polysomes, ribosomes and ribosomal subunits.


Renal segmental staining technique evaluating intra-arterial injection of supravital stains.


Rabbit homocytotropic antibody. A unique rabbit immunoglobulin analogous to human IgE. Rabbits immunized with egg albumin produce a homocytotropic antibody. The antibody is identified by its ability to produce passive anaphylaxis in rabbit skin. The time of appearance of this antibody, its persistence and recall after booster injections depends, in part, on the route of immunization and the adjuvant employed. The physicochemical characteristics of the homocytotropic antibody obtained was similar regardless of the immunization schedule used. The anaphylactic activity of these antisera showed some heterogeneity when chromatographed on diethylaminoethyl (DEAE)-cellulose, but all fractions were inactivated by heating and absorption with a specific antisera. The anaphylactic activity could be separated from rabbit IgG and IgA, and was not blocked by absorption with antisera specific for these classes of immunoglobulins. Anaphylactic activity was completely removed by absorption with a specific antiserum which did not react with any of the known rabbit immunoglobulins. The passive cutaneous anaphylaxis titer of a rabbit serum containing homocytotropic antibody was reduced by 50% after absorption with an antisera (anti-FcND) specific for human IgE. On the basis of these distinctive physicochemical characteristics, it is concluded that rabbit homocytotropic antibody represents a unique class of rabbit immunoglobulin, analogous to human IgE.


Bacilli bodies in the lumen and epithelium of the jejunum in Whipple's disease.


Comparative trial of diazepam and pheneturide in treatment of epilepsy.


Early diagnosis of pregnancy.

Early diagnosis of pregnancy.


Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer.


Herpes-simplex-virus infection after renal transplantation.


Distribution of blood between infant and placenta after birth.


Immune-complex disease of the kidney associated with chronic hepatitis and cryoglobulinaemia.


Hidden rheumatoid factor in seronegative nodular rheumatoid arthritis.


Fatal systemic measles in a child receiving cyclophosphamide for nephrotic syndrome.


Cardiovascular dynamics in women receiving oral contraceptive therapy.


Dynamic aspects of proinsulin release from perifused rat pancreas.


Inhibition of dapsone excretion by probenecid.


E.B. virus, infectious mononucleosis, and Burkitt lymphoma.


Functions of the district hospital.

Functions of the district hospital.


The burned hand.

The burned hand.


Inhalation and mist tents in cystic fibrosis.


Anatomy and function of the lymphatic capillaries.


Failure of transplacental transmission of Australia antigen.


Spread of foot-and-mouth disease.

Spread of foot-and-mouth disease.


Salmonella typhimurium, colitis, and pancreatitis.


Methysergide in mania.

Methysergide in mania.


Suction and blood-flow.

Suction and blood-flow.


Gastric emptying in infants.

Gastric emptying in infants.


Haemophilus influenzae in cystic fibrosis.


Dermatoglyphics and leukaemia.

Dermatoglyphics and leukaemia.


Blood gases after atropine administration.


Phenformin and ethyloestrenol for Raynaud's disease.


Galactose-1-phosphate-uridyl-transferase activity in blood in translocation Down's syndrome.


Detection of phenothiazine derivatives in the urine.


Testing antilymphocyte serum.

Testing antilymphocyte serum.


Pathogenesis of spina bifida.

Pathogenesis of spina bifida.


Gamma-globulin for Burkitt's lymphoma?

Gamma-globulin for Burkitt's lymphoma?


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


Genetic influences on serum-uric-acid.

Genetic influences on serum-uric-acid.


Potential carcinogenic effect of streptozotocin.


William Dameshek, M.D. Harvard.

William Dameshek, M.D. Harvard.


Urinary incontinence after prostatectomy.


Glycoproteins: their biochemistry, biology and role in human disease.


On medical priority.

On medical priority.


Acute tropical polyarthritis.

Acute tropical polyarthritis.


Studies on the reactions of rheumatoid and normal sera with undigested and papain-or pepsin-digested human gammaglobulins.


Arthritis and drugs; the ongoing quest to reveal its causes. II.


Response of ischemic heart disease to chondroitin sulfate-A.


Variables in host resistance pertaining to septicemia. I. Blood glucose level.


Effect of centrophenoxine hydrochloride on thyroxine metabolism in the rat.


Streptomycin and dihydrostreptomycin medication during pregnancy and their effect on the child's inner ear.


The relative role of eggs and adult worms in the development of liver damage in mice infected with Schistosoma mansoni.


Anti-serum to cultured human lymphoblasts: preparation, purification and immunosuppressive properties in man.


Effect of dihydrostreptomycin on protein synthesis in whole cells and in cell-free extracts of a streptomycin-dependent strain of Escherichia coli B. The effect of dihydrostreptomycin on the incorporation of amino acids into protein in antibiotic-deprived cells of a streptomycin-dependent strain of Escherichia coli B has been compared with its effect on protein synthesis in extracts from cells of the same strain. Stimulation of phenylalanine incorporation into protein in whole cells occurred within 5 min of addition of dihydrostreptomycin to a deprived culture and was maximal at an antibiotic concentration of 20 mug/ml. Stimulation of protein synthesis in cell-free extracts from antibiotic-deprived cells was maximal at a dihydrostreptomycin concentration of 10 mug/ml in systems programmed with f2-ribonucleic acid and poly AGU, whereas extracts from cells grown on nonlimiting concentrations of dihydrostreptomycin were unaffected by the addition of antibiotic. These results indicate that protein synthesis is an antibiotic-requiring process in streptomycin-dependent E. coli B.


The development of nerve-muscle junctions in monolayer cultures of embryonic spinal cord and skeletal muscle cells.


Cytochemical localization of peroxidatic activity of catalase in rat hepatic microbodies (peroxisomes). Prominent staining of rat hepatic microbodies was obtained by incubating sections of aldehyde-fixed rat liver in a modified Graham and Karnovsky's medium for ultrastructural demonstration of peroxidase activity. The electron-opaque reaction product was deposited uniformly over the matrix of the microbodies. The microbodies were identified by their size, shape, presence of tubular nucleoids, and other morphologic characteristics, and by their relative numerical counts. The staining reaction was inhibited by the catalase inhibitor, aminotriazole, and by KCN, azide, high concentrations of H(2)O(2), and by boiling of sections. These inhibition studies suggest that the peroxidatic activity of microbody catalase is responsible for the staining reaction. In the absence of exogenous H(2)O(2) appreciable staining of microbodies was noted only after prolonged incubation. Addition of sodium pyruvate, which inhibits endogenous generation of H(2)O(2) by tissue oxidases, or of crystalline catalase, which decomposes such tissue-generated H(2)O(2), completely abolished microbody staining in the absence of H(2)O(2). Neither diaminobenzidine nor the product of its oxidation had any affinity to bind nonenzymatically to microbody catalase and thus stain these organelles. The staining of microbodies was optimal at alkaline pH of 8.5. The biological significance of this alkaline pH in relation to the similar pH optima of several microbody oxidases is discussed. In addition to staining of microbodies, a heat-resistant peroxidase activity is seen in some of the peribiliary dense bodies. The relation of this reaction to the peroxidase activity of lipofuscin pigment granules is discussed.


Plasma proteins. A review.

Plasma proteins. A review.


Functional aspects of disordered immunoglobulins.


The expanding family of human immunoglobulins.


Operable heart disease in the newborn period.


Purification and electron microscopy of potato leafroll virus.


Observation on negatively stained tobacco ringspot virus and its two RNA-deficient components.


Fine structure of zinnial leaf tissues infected with dahlia mosaic virus.


Isolation and characterization of the ribonucleoprotein of influenza virus.


Immunologic basis of atopic disease.

Immunologic basis of atopic disease.


Efferent nerve fibers in the anterior visual pathways in bilateral congenital cystic eyeballs.


People workers: a local health department's experience with health education aides.


The topography of the bacterial cell wall.


Regeneration of ventral root fibers into dorsal roots shown by axoplasmic flow.


Experimental antibodies to nuclei of cells of different origin and their reactions with calf thymocyte nuclear fractions.


On the estimation of the number of antibody-forming cells.


N-terminal sequence heterogeneity of guinea pig anti-DNP kappa chains.


In vitro studies on the heterogeneity of equine antibodies to human lymphoid tissue.


Low molecular weight mercaptoethanol sensitive antibody in rabbits.


A fully automated method for immunochemical quantitation by passive hemolysis inhibition.


Batch preparation of rabbit gammaG globulin with deae-cellulose.


Histochemistry of corneal macular dystrophy.


Comparison of methods for the laboratory diagnosis of ocular adenovirus type 3 infection.


Comparative pharmacokinetics of coumarin anticoagulants. VI. Effect of plasma protein binding on the distribution and elimination of bishydroxycoumarin by rats.


Histochemistry of the periodontal ligament. IV. The glycosidases.


Natural history of prostatic obstruction. A prospective survey.


The cytology of vesicular conditions affecting the oral mucosa. 2. Keratosis follicularis.


Dependence of the topooptical staining reaction of the ergastoplasm of the liver cells on the redox state.


Cystic fibrosis: distribution of mucopolysaccharides in fibroblast cultures.


The influence of experimental thyroiditis on thyroid function.


L-Triiodothyronine and dinitrophenol-induced hypertension.


Association of "lanthanum-staining material" with hemagglutination by rubella virus.


Nerve fibers in the umbilical cord and placenta of two species of sub-human primates (Macaca phillipensis and Galago crassicaudatus).


Selective staining of neurosecretory substance. A critical analysis.


A study of some factors influencing phagocytosis of cariogenic streptococci by caries-free and caries-active individuals.


Release of histamine and formation of smooth-muscle stimulating principles in guinea-pig lung tissue induced by antigen and bee venom phosphatidase A.


Retinoblastomas with DNA precipitation.

Retinoblastomas with DNA precipitation.


Treating the cancer patient.

Treating the cancer patient.


A diagnostic preschool for atypical children.


Response characteristics of movement-detecting neurons in pretectal region of the cat.


Brain tumors induced in dogs by the Schmidt-Ruppin strain of Rous sarcoma virus. Neuropathological and immunological observations.


Mast cells in desquamative gingivitis, lichen planus, and pemphigoid.


Immunoglobulins.

Immunoglobulins.


Influence of fixatives on mast cell count.


Serum immunoglobulins in kwashiorkor.

Serum immunoglobulins in kwashiorkor.


Hypoimmunoglobulin G, hyperimmunoglobulin M, intestinal nodular hyperplasia, and thrombocytopenia. An unusual association.


Enlargement of the prostate gland.

Enlargement of the prostate gland.


The nucleolar DNA of three species of Drosophila in the hydei complex.


Experimental studies on spermiogenesis in Drosophila.


Community treatment of end-stage renal failure by dialysis and renal transplantation from cadaver donors.


Modification of the vascular lesions of rejection in cadaveric renal allografts by dipyridamole and anticoagulants.


Hypovolaemia in status asthmaticus.

Hypovolaemia in status asthmaticus.


Traumatic thrombosis of the internal carotid artery.


Diabetes mellitus presenting with bilateral foot-drop.


A controlled study of adenotonsillectomy.


Erythema nodosum leprosum: a clinical manifestation of the arthus phenomenon.


A new pancreatic hormone and the etiology of diabetes mellitus.


Diet and atherosclerosis.

Diet and atherosclerosis.


"Strange english PIGS".

"Strange english PIGS".


Ban on cyclamate sweeteners.

Ban on cyclamate sweeteners.


Chronic cyanide neurotoxicity.

Chronic cyanide neurotoxicity.


Living cells.

Living cells.