Studies on the antiperinuclear factor.

Studies on the antiperinuclear factor.


Antibodies in human brucellosis.

Antibodies in human brucellosis.


Laboratory studies in acute alcoholics.

Laboratory studies in acute alcoholics. Laboratory studies on 109 acutely intoxicated male and female alcoholics admitted to the general medical wards of a community general hospital were undertaken. Initially the program was designed to study the thyroid function of these patients, as a previous report had noted that large numbers of alcoholics were thyroid-deficient. During the study, however, other laboratory examinations, which might be confusing or misleading in alcoholics, were also measured. These additional estimations included the serum glutamic oxaloacetic transaminase (SGOT), the serum cholesterol and the serum amylase. No patients were found to be hypothyroid. The results of the tests indicate the need for caution in interpreting SGOT and serum amylase results in acute alcoholics.


Skull bones in plastic.

Skull bones in plastic.


Potentiation of the tolbutamide effect by dicoumarol.


The use of heavy metal salts as electron stains.


Induction of passive cutaneous anaphylaxis in monkeys by human gamma-E antibody.


Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.


Infectious hepatitis.  Evidence for two distinctive clinical, epidemiological, and immunological types of infection.


Studies of rubella and its prevention with immune globulin.


Increased red blood cell production in chronic myelocytic leukemia.


Oral contraceptives for haemophilia.

Oral contraceptives for haemophilia.


Leukaemia and neonatal death-rates.

Leukaemia and neonatal death-rates.


Metabolic acidosis of the cerebrospinal fluid associated with subarachnoid haemorrhage.


A controlled trial of long-term steroid treatment in haemophilia.


Adrenocartical response to the stress of an acute myocardial infarction.


X-linked retinitis pigmentosa and linkage studies with the Xg blood-groups.


Platelet abnormality in human scurvy.

Platelet abnormality in human scurvy.


Evidence of a pseudomyxovirus in the brain in subacute sclerosing leucoencephalitis.


Effect of oral contraceptives on haemoglobin, packed-cell volume, serum-iron, and total iron-binding capacity in healthy women.


Atopic eczema and thyroid autoimmunity.

Atopic eczema and thyroid autoimmunity.


Mysterious fracture of the tibia.

Mysterious fracture of the tibia.


Bleeding tendency associated with "new" abnormality of platelet behaviour.


Hypotension after angiography.

Hypotension after angiography.


Slowly developing pressor response to small amounts of noradrenaline in rabbits.


Training the specialist.

Training the specialist.


Delayed hypersensitivity.

Delayed hypersensitivity.


Anaesthesia for dental surgery.

Anaesthesia for dental surgery.


Pulmonary respirator syndrome.

Pulmonary respirator syndrome.


The reason why.

The reason why.


Prevention of rhesus haemolytic disease.


Foot-and-mouth disease in man.

Foot-and-mouth disease in man.


IV. Cellular immune faculties. Competence and memory.


Lost to follow-up.

Lost to follow-up.


Corneal staining in systemic lupus erythematosus.


2 types of lambda polypeptide chains in human immunoglobulins. Two antigenic subtypes of human lambda polypeptide chains were distinguished by rabbit antiserum produced to a lambda Bence Jones protein. Lambda Bence Jones proteins and G myeloma proteins with lambda light chains were identified as being in one or the other subtype. The Oz (+) lambda chain subtype is present in light chains from pooled normal human immunoglobulin G and in whole normal immunoglobulin G molecules.


Autoradiographic plaques for the detection of antibody formation to soluble proteins by single cells. Single cells that synthesize antibody to soluble proteins can be detected and counted by an autoradiographic procedure. The method is based on the specific binding of I(131)-labeled antigen to the antidogy which has been produced by and has diffused around cells in an agarose medium and which has been precipitated by an antibody to gamma globulin. The antigen-binding zones appear as dark spots on high-speed x-ray film exposed to the dried agarose preparations.


Exploratory and analytical survey of therapeutic exercise. Fifth question and discussion period.


Electroencephalographic and eye movement patterns during sleep in chronic schizophrenic patients.


Steady potential of cerebellar cortex. Results of direct, olivo- and ponto-cerebellar activation.


Synchronization characteristics of paroxysmal EEG activity.


Cross-correlation of human alpha activity: normative data.


Topographical arrangement between thalamic ventro-lateral nucleus and precentral motor cortex in man.


Influence of stimulation of the optic pathways on hippocampal after-discharges in the rabbit.


Reversible depression of hippocampus by local injections of anesthetics in monkeys.


Effects of imipramine on the sleep-dream cycle: an EEG study in boys.


The electrical activity of the olfactory bulb in cats with nasal and tracheal breathing.


The EEG in familial dysautonomia (Riley-Day syndrome).


Technical advances in the analysis of single, acoustically evoked potentials.


Behavioral experimental epilepsy in monkeys. I. Clinical seizure recording apparatus and initial data.


Immunofluorescence study of rheumatoid factor in liver tissue of patients with rheumatoid arthritis and hepatic diseases.


Basement zone antibodies in bullous pemphigoid.


Etiology of viral hepatitis.

Etiology of viral hepatitis.


Role of the carrier protein in the antibody elicited to DNP hapten.


Trace proteins in biological fluids. IV. Physicochemical properties and sites of formation of gamma-trace and beta-trace proteins.


Radiation studies on mice of an inbred tumor-resistant strain. The alteration of endogenous susceptibility to amyloidosis by x-irradiation.


Inhibition of cell-free foot-and-mouth disease virus-ribonucleic acid synthesis by antibody.


Main-stem extrasystoles with aberrant ventricular conduction mimicking ventricular extrasystoles.


Rheumatoid arthritis with IgA deficiency.


Autoimmune proliferative glomerulonephritis in monkeys.


Release of histamine from human basophils.


An evaluation of human lymphocyte nuclear RNA with acridine orange.


Serum esterases among registered breeds of dogs as revealed by immunoelectrophoretic comparisons.


Altered thyroxine metabolism resulting from the chemical carcinogen 3-methylcholanthrene.


Effects of sex hormones and antifertility steroids in brain thresholds in the rabbit.


Combination of delipidized high density lipoprotein with lipids.


Effects of norethandrolone on the transport in serum and peripheral turnover of thyroxine.


Tolerance to the lenticular effects of opiates.


Allergic gastroenteropathy. A cause of excessive gastrointestinal protein loss.


Scanning electron microscopy of sectioned tissue.


The placenta in cases of hemolytic disease of the newborn.


Antigenic analysis of entamoeba histolytica by means of fluorescent antibody. V. Comparison of 15 strains of entamoeba with information on their pathogenicity to guinea pigs.


Production and characterization of arbovirus antibody in mouse ascitic fluid.


Skin and muscle indurations in phenylketonuria.


Morphology of Mycobacterium leprae in tissue sections.


Hereditary syndromes with auditory and dermatological manifestations.


Ultraviolet light-induced kinin formation in human skin.


The role of cell-uptake of polycyclic compounds in photodynamic injury of Tetrahymena pyriformis.


The uptake and localization of proteins, Evans Blue and carbon black in the normal and pathological thymus of the guinea-pig.


Beta-1C and immune globulin formation in vitro by tissues from germ-free and conventional rodents of various ages.


Serial sampling of cell cultures using gelatin coated slides in coplin jars.


Studies of cryoproteins in systemic lupus erythematosus. Cryoproteins observed in patients with systemic lupus erythematosus were shown to be of "mixed type," consisting largely of IgG and IgM. The IgM moiety possessed anti-IgG globulin reactivity and precipitated in the cold after mixing with a source of IgG. The IgM fraction of one cryoprotein precipitated only with the same patient's IgG. Antisera prepared against purified cryoproteins regularly recognized IgM, IgG, the 11 S component of C', and alpha(2)-macroglobulin. C'4 (beta(1E)) and C'3 (beta(1C)) were recognized by four and two antisera, respectively. Antisera prepared against two cryoproteins reacted (after absorption) only with the sera of origin. These "unique" antigens were associated with IgM, were destroyed by mercaptoethanol treatment, and, in one patient, were shown to disappear subsequent to clinical improvement.


Studies on the metabolic error in Refsum's disease. Studies utilizing mevalonic acid-2-(14)C and D(2)O as precursors failed to provide evidence for an appreciable rate of endogenous biosynthesis of phytanic acid in a patient with Refsum's disease. Orally administered tracer doses of phytol-U-(14)C were well absorbed both by seven normal control subjects (61 to 94%) and by two patients with Refsum's disease (74 and 80%). The fraction of the absorbed dose converted to (14)CO(2) in 12 hours was 3.5 and 5.8% in Refsum's disease patients and averaged 20.9% in seven control subjects. Labeled phytanic acid was demonstrated in the plasma of both control subjects and patients given phytol-U-(14)C, establishing phytol in the diet as a potential precursor of phytanic acid. This labeled phytanic acid had disappeared almost completely from the plasma of the seven control subjects by 24 to 48 hours, whereas it persisted at high concentrations in the plasma of the two patients for many days. We conclude that the phytanic acid accumulating in Refsum's disease is primarily of exogenous origin and that patients with Refsum's disease have a relative block in the degradation of phytanic acid and possibly other similar branched-chain compounds. This may relate to a deficiency in mechanisms for release of phytanic acid from stored ester forms or, more probably, to reactions essential to oxidative degradation of the carbon skeleton.


Observations on commensal cultures of Bordetella bronchiseptica and rat hepatoma cells. Electron microscopy.


The ultrastructure of the functioning kidney.


Electron microscopic localization of phosphatase activities within striated muscle fibers.


Changing trends in infectious hepatitis.


Cancer of the colon.

Cancer of the colon.


The Langerhans cell in human gingival epithelium.


A modification to an established technique for the assessment of fissure caries in the rat.


Histological changes in exocrine rat pancreas after water deprivation.


Radioactive isotopes in clinical medicine. I.


Interactions of the complement system with the surface and endotoxic lipopolysaccharide of Veillonella alcalescens. Electron microscopic studies demonstrated that lesions were produced on the endotoxic lipopolysaccharide (LPS) as well as on the cell surface of V. alcalescens after reaction with fresh guinea pig serum. These lesions were approximately 90 A in diameter, and were seen on two characteristic structural entities derived from LPS preparations after incubation with serum. The use of numerous inhibitors, inactivators, and reaction conditions affecting hemolytic C' activity revealed that these lesions were mediated by the C' system. Concomitant with lesion formation, C' was fixed; the effect on classical C'3 activity was pronounced. It is concluded that endotoxic LPS, as contained in the outer three-layered membrane of the bacterial cell, is a substrate for the C' enzymes. It is suggested that certain biological activities of endotoxin may derive from its effects on the C' system.


Biological activity of the cleavage product of human immunoglobulin G with cyanogen bromide. Treatment of human IgG with cyanogen bromide in 0.05 M HCl under specified conditions resulted in the cleavage of about half of its methionyl peptide bonds. A major fragment of about 5S was isolated from the reaction mixture by gel filtration in quantitative yield. The CNBr fragment reacted fully with goat antiserum against human light chain, but its reaction with anti-heavy chain was markedly decreased. The treatment with CNBr caused a drastic decrease in the following biological activities of IgG: complement fixing, skin binding, reaction with antiglobulin factors, and reaction with specific anti-Gm(12) serum. On the other hand, the reaction with serum of anti-Gm(1) or anti-Gm(4) specificity was not impaired and antibody activity, namely antistreptolysin and isohemagglutinin, was retained after the treatment with CNBr. It is concluded that the CNBr cleaves preferentially the methionyl bonds in the Fc portion of IgG, and that the major fragment obtained, denoted F(ab'')(2), has still the combining properties of a divalent antibody. The possible therapeutic uses of F(ab'')(2) are discussed.


Pigment formation in mast cells in tissue culture.


The initial, rapid-phase disappearance of intravenous radioinsulin in diabetes.


The genetic control of gamma-globulin heavy chains. Studies of the major heavy chain subgroup utilizing multiple genetic markers. The genetic control of gammaG1-heavy chains was investigated by taking advantage of two recently described genetic antigens, Gm(z) and Gm(y), both produced by heteroimmunization of rabbits with myeloma proteins. These were studied in conjunction with known genetic markers, Gm(a) and Gm(f). The results indicated that among Caucasians there are two major allelic genes, Gm(za) and Gm(fy), coding for distinct varieties of gammaG1-heavy chains. Each of these contains a pair of genetic antigens which are located on different fragments of the chain and can be separated by enzymatic splitting with papain. The different areas of the heavy chains appear to be under the control of the same gene. In Mongoloid populations a grouping of three genetic antigens, Gm(f), (y), and (a), was found on isolated myeloma proteins and normal gamma-globulins indicating the presence of a Gm(fya) gene. The possible genetic events leading to the contrasting Caucasian and Mongoloid genes are discussed. In the gamma-globulin system the occurrence of multiple genetic antigens in different positions of the same heavy chains is the general rule. A better understanding of the relationships between the genes for the gammaG1-subgroup to those for the gammaG2- and gammaG3-subgroup has been obtained through the use of the multiple genetic markers. Strong evidence was obtained for intergenic crossover mechanisms to explain racial differences in the relationships of these genes as well as certain unusual gene complexes found through family studies. Further evidence was obtained for mapping the closely linked genes for the three subgroups in a specific order.


Phylogeny of immunoglobulin structure and function. I. Immunoglobulins of the lemon shark. Lemon sharks immunized with bovine serum albumin produced two molecular forms of antibodies detectable by passive hemagglutination of antigen-coated, tanned sheep erythrocytes. Throughout the course of immunization 2-ME-sensitive antibody was associated with a 19S immunoglobulin fraction (4-5 mg/ml serum) while late in the course of immunization antibody was found also associated with a 7S immunoglobulin fraction (7-8 mg/ml serum). No evidence for any anamnestic response was found in these animals. Naturally occurring hemagglutinins for sheep erythrocytes were found to be 2-ME-sensitive and present in the 19S immunoglobulin fraction. These immunoglobulin fractions were readily purified by DEAE-cellulose chromatography and Sephadex G-200 gel filtration. Both immunoglobulin molecules yielded equimolar amounts of H and L polypeptide chains when subjected to extensive reduction and alkylation followed by gel filtration in 5 M guanidine-HCl. Antigenically reactive H and L chains were obtained by partial reduction and alkylation followed by gel filtration in 1 M propionic acid. The 7S and 19S immunoglobulin H chains were indistinguishable by fingerprints of tryptic digests, disc electrophoretic patterns, antigenic properties, and mass (molecular weight approximately 70,000), thus suggesting these two molecules to belong to the same immunoglobulin class. The shark 19S and 7S immunoglobulin L chains were indistinguishable from each other by similar criteria and were different from the H chains. These L chains exhibited the electrophoretic heterogeneity of their mammalian counterparts. The 7S (shark immunoglobulin) molecule was shown to have a molecular weight of approximately 160,000 and to consist of 2H and 2L polypeptide chains (total mass congruent with180,000). The 19S molecule was shown to have a molecular weight of 800,000-900,000; therefore, there were probably five 7S subunits per 19S molecule, comparable to mammalian gammaM. Other reasons for considering the 7S and the 19S lemon shark molecules to belong to a class of immunoglobulins comparable to the gammaM class of mammals are that they both have high carbohydrate contents, and H chains of mass similar to micro chains. The lemon shark serum proteins with electrophoretic mobilities comparable to gamma G of mammals were not related to the immunoglobulins of this species. These proteins had no antibody activity and had no antigenic or chemical similarity to either the H chains, the L chains, or the intact immunoglobulin molecules from the lemon shark.


Oragrafin and the triiodothyronine uptake test of thyroid function.


Effect of cortisone on the PBI and the resin uptake I-131-triiodothyronine.


Limited heterogeneity of gamma globulin in hypogammaglobulinemia. When serums of 11 patients with hypogammaglobulinemia were examined by acrylamide-gel electrophoresis, combined with diffusion analysis, for the gamma chain of immunoglobulin G, the electrophoretic distribution of immunoglobulin G differed from that of normal individuals. The differences consisted of limited heterogeneity and bimodal distributions of the proteins at times. Isolated immunoglobulin G from four of the patients showed similar phenomena. The findings indicate a deficient gene population in these patients.


Lambda chains in cold agglutinins.

Lambda chains in cold agglutinins. Type L light chains have been found in the cold agglutinins in the serums of three patients with chronic hemolytic anemia. Altholugh two of these cold agglutinins are unusual in that they do not have specificity to I or i red-cell antigens (one of these has, in addition, cryoglobuilin property), the third is a cold agglutinin of I specificity. Previously reported cold agglutinins from such patients have all been of type K; this is tlhe first report of type L cold agglutinins associated with chronic hemolytic anemia.


Infusion thrombophlebitis and its prevention.


Estimation of beta-IG globulin in glomerulonephritis. Serum beta(IC) globulin, the third component of the complement system, was estimated by the single diffusion method (Oudin) and its significance in human glomerulonephritis was evaluated. This protein was depressed in two of three cases of acute proliferative glomerulonephritis and nine of 12 cases of acute glomerulonephritis. Beta(IC) globulin continued to be low in two cases of active subacute glomerulonephritis whereas it returned to normal in five of the cases of acute glomerulonephritis. Values were normal in eight patients with membranous glomerulonephritis, four with chronic glomerulonephritis and one with hereditary glomerulonephritis, as well as in patients with other renal diseases and diseases of non-renal origin. In addition, levels were elevated in six patients with diseases of possible immune pathogenesis. It is concluded that beta(IC) globulin estimation is a useful aid in the diagnosis and prognosis of glomerulonephritis in humans.


A new technique for detecting malignant cells in sputum. Evaluation in 200 patients having primary cancer of the lung.


Evaluation of chemotherapy of cancer by regional perfusion.


Concluding remarks: the regulation of hemoglobin and immunoglobulin synthesis.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23-1967.


Serum complement level in patients with nephrotic syndrome.


Corneal amyloidosis.

Corneal amyloidosis.


Paroxysmal cold haemoglobinuria and measles.


Serum protein-bound iodine and serum thyroxine during perphenazine therapy.


Commuter exposure to atmospheric lead.

Commuter exposure to atmospheric lead.


A direct approach to cochlear anatomy and pathology in man.


Acid phosphatases from different organs and animal forms compared by starch-gel electrophoresis.


Quantitative comparison of immunoglobulins in atopic (reaginic) and nonatopic (nonreaginic) individuals: higher gamma-D levels in atopic sera.


Studies on neuromelanin. I. A melanin system in the human adult brainstem.


Immune deficiencies, aplastic anemia and abnormalities of lymphoid tissue in thymoma.


Irradiation for treatment of carcinoma of the lung in indigent and private patients.


Sex seminars with medical students.

Sex seminars with medical students.


Histochemical reactions of the enterochromaffin cells and the 5-hydroxytryptamine content of the mammalian duodenum.


Role of the thymus and other central lymphoid tissues in immunological disease.


Comparative acute toxicity of four drugs. A study of neomycin, gentamicin, kanamycin, and dihydrostreptomycin.


Transition from elastin to collagen in internal elastic membranes. Staining, polarization, and fluorescence microscopic studies of the renal arterial system.


Effects of stimulus and response contingencies on a surface negative slow potential shift in man.


Changes in latency and form of the photically induced average evoked response in human infants.


Visullay evoked cortical potentials and reaction time in relation to site of retinal stimulation.


On the cerebral evoked response in man as a function of the intensity of flicker stimulation.


DC potential changes recorded between brain and skull in the rabbit after eating and drinking.


Local blood flow in different regions of the brain-stem during natural sleep and arousal.


Visual evoked potentials as recorded from the scalp and from the visual cortex before and after surgical removal of the occipital pole in man.


An appraisal of hyoscine as an EEG activating agent.


Electronic simulation as an aid in evaluating computer-analyzed EEG data.


Evoked potential recovery from tape recorded zero crossings of the EEG.


An aspect of the physiology of corpus callosum.


Collective teaching of clinical electroencephalography by projecting graphs on a large screen.


Electro-clinical study of a case of addiction to Merinax.


The EEG response to hyperpnea and the acid-base equilibrium in the blood under the influence of Ospolot.


Hoffmann's reflex in children with cerebral palsy.


Somato-sensory evoked cortical potentials in man.


The carpal tunnel syndrome.

The carpal tunnel syndrome.


Polygraphic recordings during syncope.

Polygraphic recordings during syncope.


A particular change in EEG morphology.

A particular change in EEG morphology.


The electroencephalogram in complex forms of migrane.


Changes of intracranial pressure, cortical impedance and oxygen availability associated with changes in the EEG during sleep.


Traps, tricks and triumphs in EEG: 1936-1966 (the second Geoffrey Parr Memorial Lecture).


Pneumoencephalographic and EEG observations in 106 children with infantile spasms.


The echoencephalogram as an aid to interpreting electroencephalograms.


Average steady state responses to coloured stimuli.


EEG activation by procyclidine hydrochloride in temporal lobe epilepsy.


Structure of enzymes in vitro.

Structure of enzymes in vitro.


Survival in 6086 cases of bronchial carcinoma.


Hypercalcaemia and gastric hypersecretion in the familial endocrine-adenoma syndrome.


Circulatory effects of heroin in patients with myocardial infarction.


Premyxoedema and coronary-artery disease.


Factor-IX deficiency in the nephrotic syndrome.


Value of hydroxyproline indices in malnutrition.


Suppression of Coombs-positive haemolytic anaemia in NZB mice by antilymphocyte globulin.


Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.


Heparin treatment of haemorrhagic diathesis in cyanotic congenital heart-disease.


Interpretation of laboratory tests.

Interpretation of laboratory tests.


A simple automatic respirator.

A simple automatic respirator.


Ulcerative colitis and Crohn's disease.

Ulcerative colitis and Crohn's disease.


Immunosuppressive drugs and chronic renal disease.


Heroin in myocardial infarction.

Heroin in myocardial infarction.


Proteases in mast cells.

Proteases in mast cells.


Cerebellar haemangioblastoma a misnomer.


An ABC of modern immunology. VI. Cell-mediated immunity.


Sulphormethoxine in chloroquine-resistant falciparum malaria in Thailand.


New evidence for islet-cell origin of insulin-like activity in serum.


Functional activity of a chemically induced thymic sarcoma.


Effect of antilymphocytic antibody and antibody fragments on skin-homograft survival and the blood-lymphocyte count in rats.


Variability of gastric secretion in patients with and without the Zollinger-Ellison syndrome.


Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan.


Receptor mechanisms in the hyperglycaemic response to adrenaline in man.


Hypothermic subarachnoid irrigation for intractable pain.


Reversal of diazoxide effects by tolbutamide.


Insulin-like activity as a third islet-cell hormone.


Barometer of medical education.

Barometer of medical education.


Islet-cells and insulin.

Islet-cells and insulin.


Responsibilities of research.

Responsibilities of research.


Colloid infusion and haemodilution after severe HAEMORRHAGE.


Fever in Still's disease.

Fever in Still's disease.


"Irritable colon of childhood".

"Irritable colon of childhood".


Sulphonamides in malaria.

Sulphonamides in malaria.


An ABC of modern immunology. VII. Immunological competence.


Intensive care as a specialty.

Intensive care as a specialty.


Arrangements for hospital medical staff.


With a surgical team in South Vietnam.

With a surgical team in South Vietnam.


"The safety of oral contraceptives".

"The safety of oral contraceptives".


Effects of oral contraceptives.

Effects of oral contraceptives.


Oral contraceptives and depression.

Oral contraceptives and depression.


Methotrexate in psoriasis.

Methotrexate in psoriasis.


Allergic dermatitis produced by oral clioquinol.


Experimental eosinophilia X. Relation of antigen-antibody complex size and protein molecular weight to cell responses.


Reduction and alkylation of immunoglobulins from normal, irradiated and splenectomized rabbits.


Fetal liver: a source of immunoglobulin producing cells in the mouse.


Smallpox vaccination of patients with increased risk of complications.


Interstitial keratitis associated with hidradenitis suppurativa.


Fetal alpha-1-globulin of rat serum.

Fetal alpha-1-globulin of rat serum.


Circulating LgG globulin anti-LgG globulin complex in a patient with carcinoma of the lung and severe neuromyopathy.


Postthymectomy wasting associated with autoimmune phenomena. I. Antiglobulin-positive anemia in A and C57BL-6 Ks mice. 1. Mice of A and C(57)BL/6 Ks strains, thymectomized at birth acquire wasting disease in 84.1% (A) and 77.1% (C(57)BL/6 Ks) of the cases. There is no sex predelection. 2. Anemia in these animals is characterized by shortened red cell survival and increased fragility to hypotonic salt solutions. Among thymectomized A mice reticulocytosis is absent and extramedullary hematopoiesis is found in the spleen in the presence of bone marrow hypoplasia for the erythroid and lymphocyte series. 3. Positive antiglobulin tests of the red cells were observed in all the thymectomized C(57)BL/6 Ks (7/7) and 71.2% of the A strains (62/87). Normal mice do not show positive Coombs' tests. 4. The globulin coat on the A strain consists of IgM, whereas beta(1C) and IgG are not detectable. By contrast, red cell coats of NZB mice developing spontaneous autoimmune hemolytic anemia show IgM and beta(1C), but these erythrocytes do not react with anti-gamma chain antibodies. Another difference in the globulin coats of the two types of erythrocytes is that the IgM on NZB red cells has available light chain determinants but these are apparently hidden or absent in the case of sensitized erythrocytes. The difference in antibody coating, association with a component of complement in one but not the other, suggests a different mechanism for the immune surface phenomenon in each instance. 5. Anemia in NZB mice is associated with reticulocytosis while that in thymectomized A mice is not. 6. Thymectomy appears to initiate a chain of events leading to a series of autoimmune phenomena which may be due to alteration in host response consequent to loss of thymic tissue and thymic dependent functions or alternatively to infection to which increased susceptibility exists as a result of thymic extirpation.


Morphology of pancreatic B cell secretion in neonatal rabbits.


Fine structural studies on the development of heterophil, eosinophil, and basophil granulocytes in rabbits.


Quantitative studies of late radiation changes in hematopoietic organs of RFM-U and BALB-c mice and their relation to leukemia.


"The safety of oral contraceptives". A case study in medical administration.


Carcinoma of oesophagus treated by coloplasty and irradiation.


Isolation of immunoglobulin A (IgA) from human colostrum.


Reduction and proteolytic degradation of immunoglobulin A from human colostrum.


An experimental test of two general relationships to describe the adsorption of antibodies by cells and tissues.


An evaluation of the number of b4 allotypic determinants on rabbit gamma-G-immunoglobulin using double-labeled, soluble complexes with univalent antibody fragments.


Studies on papain produced subunits of human gamma-G-globulins. I. Physicochemical and immunochemical properties of gamma-G-globulin Fc-fragments.


Studies on papain produced subunits of human gamma-G-globulins. II. Structures of  peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.


An in vivo assay to determine the ability of antibody subunits to bind to antigen.


Verbal and symbolic processes in slips of the tongue.


The immune response to human gamma-G-immunoglobulin in rabbits unresponsive to Fc fragment and H chain protein.


Nature of the immune response to Mycoplasma pneumoniae.


Immunochemical properties of Fc fragment of rabbit gamma-G-globulin.


Protein conjugates of polysaccharide from Cryptococcus neoforman s.


Canine immunoglobulins. I. Evidence for six immunoglobulin classes.


Canine immunoglobulins. II. Antibody activities in six immunoglobulin classes.


Precipitation and neutralization of bacteriophage f2 by rabbit antibodies.


Macroglobulins in chronic pancreatitis and liver cirrhosis. Comparison with the rheumatoid factor macroglobulin.


Current cancer concepts. Adrenalectomy as palliative treatment.


A clinical trial of the progestational steroid ethynodiol diacetate as an oral contraceptive.


Histochemical study of dentine in rats following hypophysectomy.


Autoradiography with 125-I-labeled antibodies as a means of localizing TMV antigen in plant cells.


Sweat-gland carcinoma. A clinicopathologic problem.


A rapid method of preparing smears of effusions and solid mass aspirates for cytologic diagnosis.


Renal homotransplantation. The cytology of the urine sediment.


Methods for preparing tissue culture in disposable microplates and their use in virology.


The venereal nature of inclusion conjunctivitis.


Comparison of procedures for laboratory diagnosis of oculogenital infections with inclusion conjunctivitis agents.


Phosphorylation coupled to malate oxidation in Acetobacter xylinum.


Studies of the congenitally goitrous sheep. The iodinated compounds of serum, and circulating thyroid-stimulating hormone. 1. A group of normal and congenitally goitrous Merino sheep were investigated to identify the metabolic defect present in the abnormal animals. 2. Protein-bound iodine concentrations of serum from goitrous animals (average 5.7mug./100ml.) were higher than normal (average 4.2mug./100ml.; P 0.001), but the hormonal iodine measured as butanol-extractable (131)I was low in the serum of goitrous (average 40.3% of protein-bound (131)I) compared with that of normal (84.2%; P 0.02) sheep. The non-hormonal iodine of the serum of goitrous sheep appeared to include iodotyrosines and iodinated protein. 3. Starch-gel-electrophoretic separations of sera from normal and goitrous sheep after (131)I injection (100-500muc) showed no qualitative differences in the radioactivity of protein components. No significant differences in thyroxine-binding in vitro by serum proteins of normal and goitrous sheep were observed. 4. The clearance rates of (131)I-labelled iodotyrosines (t((1/2)) 1.2-2.9hr.) and iodothyronines (t((1/2)) 33.5-47.4hr.) were similar in normal and goitrous sheep. 5. The concentration of circulating thyroid-stimulating hormone was significantly higher (P<0.01 in three sheep, P<0.05 in one sheep) in goitrous sheep. 6. The congenital goitre appears to be due to compensatory hypertrophy of the gland resulting from an inability to synthesize an adequate supply of thyroid hormone.


The conformation of eye-lens proteins studied by means of optical rotatory dispersion.


Localized swelling of the inner compartment in negatively stained mitochondria.


Conformational changes in sperm-whale metmyoglobin due to combination with antibodies to apomyoglobin. 1. No ferrihaem was detected in the precipitate formed by metmyoglobin with an antiserum to apomyoglobin and the extinction at 410mmu of metmyoglobin, due to ferrihaem, was decreased by the univalent fragments of apomyoglobin antibodies. It was concluded that the combination of apomyoglobin antibodies with metmyoglobin caused the release of ferrihaem. As the removal of ferrihaem from metmyoglobin is accompanied by a conformational change, it was concluded that the conformation of metmyoglobin was altered by the apomyoglobin antibodies. 2. Antisera to metmyoglobin were divided into two groups; antisera of the first group revealed differences between the immunological reactivities of metmyoglobin and apomyoglobin, whereas no differences were detected with antisera of the second group. 3. Metmyoglobin was only partially re-formed by adding haematin to the precipitate produced by apomyoglobin with an antiserum of the first group, whereas complete re-formation of metmyoglobin was achieved in the presence of antisera of the second group. No metmyoglobin was formed on the addition of haematin to the precipitates produced by either metmyoglobin or apomyoglobin with the anti-apomyoglobin serum. 4. Immune precipitates formed by antisera to metmyoglobin dissociated at pH1.8, whereas those formed by the anti-apomyoglobin serum did not dissociate. 5. These results suggest that apomyoglobin possessed different conformations when combined with metmyoglobin antibodies and apomyoglobin antibodies.


Carboxy-terminal amino acids of gamma-A and gamma-M heavy chains. The carboxy-terminal amino acids of alpha-and micro-chains from human immunoglobulins and alpha-chains from mouse immunoglobulins have been determined by carboxypeptidase digestion and hydrazinolysis. The data suggest the following carboxy-terminal sequences: human micro: Ala-Gly-Thr-Cys-TyrCOOH; human alpha: Thr-Cys-TyrCOOH; murine alpha: (Ileu, Cys)-TyrCOOH.


Electrophoresis of cerebrospinal fluid proteins.


Inhibition of protein and RNA synthesis in HeLa cells by levallorphan and levorphanol.


TRIC agent infections of the eye and genital tract.


Natural history of trachoma in Taiwan school children.


Trachoma in Jamaica. Epidemiologic and microbiologic observations on mild disease.


Clinical evaluation of monkey eye infection with TRIC agent. A numerical scoring system of disease severity.


Studies of tubular alterations in diffuse renal disease. II. Quantitative evaluation of cellularity and length of proximal convoluted tubules in the kidney of lupus nephritis.


Catatonia induced in monkeys by antibrain antibody.


Bear meat trichinosis. Profound serum protein alterations, minor eosinophilia, and response to thiabendazole.


Natural tropomyosin and the factor sensitizing actomyosin adenosine triphosphatase to ethylenedioxybis(ethyleneamino)tetra-acetic acid.


The fine structure of fibrin.

The fine structure of fibrin.


Studies on experimental insulin immunity. II. The organ distribution of insulin in immune rabbits.


Eosinophil granules and uranyl acetate. An electron microscope study of guinea-pig bone marrow.


An analysis of the role of serum in parathyroid hormone-induced bone resorption in tissue culture.


A new fixation method for Schizosaccharomyces pombe.


Loss of 3H-thymidine-labelled material from chick blastoderm nuclei after feulgen hydrolysis.


Mechanisms of the inhibition of chemotaxis by phosphonate esters. Studies in the time course of the response of rabbit polymorphonuclear leukocytes (PMN's) to the complement-associated chemotactic factor have revealed that the response is virtually complete by 60 min with less than 15% additionally responding cells thereafter. Phosphonate esters with a well defined capacity to inhibit serine esterases have been used to study the cell-associated enzymes of the rabbit PMN required for the chemotactic response. Two types of inhibition of the cell response to the chemotactic factor have been found: (a) cell-dependent inhibition occurring as a result of pretreatment of PMN's with phosphonate esters; and (b) chemotactic factor-dependent inhibition demonstrated only when the phosphonate ester is present during the chemotactic response. Differences were found in these two modes of inhibition caused by various phosphonates, in terms of their time course of inhibition, in the dose response curves, and in the structure-activity relationships. It has been conclusively demonstrated that the phosphonate esters have no direct inhibitory effect on the chemotactic factor. This has been shown by retention of activity of the chemotactic factor following incubation with phosphonate esters and subsequent removal by dialysis. In addition, the activity of the chemotactic factor and its physical-chemical characteristics in density gradient ultracentrifugation were unaltered in the continued presence of a potent phosphonate inhibitor of chemotaxis. The uptake of the dye trypan blue was studied in cells treated with phosphonate in such a manner to induce cell-dependent inhibition of chemotaxis. Even when 84% cell-dependent inhibition of chemotaxis occurred, no uptake of the dye by leukocytes was found. Thus, phosphonate-induced inhibition of cell responsiveness in chemotaxis was not associated with generalized cell damage as defined by exclusion of the dye. It is concluded that cell-dependent inhibition is due to the presence of a cell-bound esterase which is already activated and thus susceptible to inhibition by phosphonate esters before contact of the cell with the chemotactic factor. The second type of inhibition, chemotactic factor-dependent inhibition, is considered due to a cell-bound esterase which becomes susceptible to inhibition by phosphonate esters only after contact of the PMN with the chemotactic factor. It is postulated that the chemotactic factor activates this phosphonate-resistant precursor making it susceptible to the inhibitory action of the phosphonate ester.


The regulation of pinocytosis in mouse macrophages. IV. The immunological induction of pinocytic vesicles, secondary lysosomes, and hydrolytic enzymes. Bovine sera contain factors which are capable of agglutinating mouse erythrocytes and stimulating the pinocytic activity of cultivated mouse macrophages. The hemagglutinating and vesicle-inducing activities of sera increase with the age of the animal and are absent in fetal calf serum. The majority of this material is recovered in globulin fractions prepared with Na(2)SO(4)-(NH(4))(2)SO(4) and is absent in bovine fraction II. It behaves as a macroglobulin in studies employing zone electrophoresis, Sephadex G-200 filtration, sucrose density gradient centrifugation, and in its sensitivity to 2-mercaptoethanol and heat. Absorption of bovine sera with either mouse erythrocytes or spleen cells removes the hemagglutinating and pinosome-inducing properties of the sera. The addition of small quantities of bovine macroglobulin to mouse macrophages results in a stimulation of pinocytic activity, phase-dense granule formation and the cellular content of three acid hydrolases. In the presence of heat-labile factors, the macroglobulin initiates the hemolysis of mouse erythrocytes and the cytolysis of mouse macrophages. This material is thought to represent an interspecies gammaM-type antibody directed against common antigenic determinants on the mouse erythrocyte and macrophage surface.


LE cell test and antinuclear antibodies.


Dangers of resonium A in the treatment of hyperkalemia in renal failure.


Treatment of hyperkalemia with a calcium-resin.


Freud's contribution to language theory.


The LE factor in rheumatoid arthritis. Clinical and serological studies.


Serological findings in cases of juvenile rheumatoid arthritis.


Immunoglobulins in umbilical cord plasma. I. Healthy infants.


Immunoglobulins in umbilical cord plasma. II. Congenital deformities, other abnormalities, and multiple pregnancies.


Use of ampicillin instead of streptomycin in Salmonella-infected mouse peritoneal macrophage cultures.


Criteria for the purity of isolated proteins.


Gm(s) and Gm(t): genetic determinants of human gamma-globulin.


Electrophoretic determination of leptospiral enzymes.


Phosphorylation in hydrogen bacteria.

Phosphorylation in hydrogen bacteria. The electron-transport system of cell-free extracts obtained from Hydrogenomonas H-20 has been studied with particular reference to phosphorylation associated with the oxyhydrogen reaction. Cell-free preparations of this organism exhibit oxidative phosphorylation with hydrogen and succinate as electron donors. This activity could be uncoupled with a number of agents. Ratios of phosphorylative activity to oxidative activity observed varied from 0.2 to 0.7. Factors affecting the efficiency of phosphorylation were examined. Inhibitor and spectrophotometric studies indicated that phosphorylation with hydrogen as electron donor occurs exclusively at a site in an abbreviated electron transport chain between H(2) and cytochrome b. The possible occurrence of a cytochrome b oxidase and the requirement for a quinone are discussed, as well as the correlation between the abbreviated pathway and the energy generation by the cell. Evidence is presented which indicates that nicotinamide adenine dinucleotide does not participate in the hydrogen oxidation path which is coupled to adenosine triphosphate formation.


Thyroid function in chronic excess iodide ingestion: comparison of thyroidal absolute iodine uptake and degradation of thyroxine in euthyroid Japanese subjects.


Nonhormonal iodine escape from the normal and abnormal thyroid gland.


Effect of hyperthyroidism and hypothyroidism on collagen metabolism.


An initial evaluation of animated serial sections as an instructional method for facilitating three-dimensional awareness of anatomic regions.


Effects of therapeutic and toxic doses of propylthiouracil in rats.


The induction of paracrystalline thread-complexes in the nuclei of amphibian cells by actinomycin D and other DNA-binding antibiotics.


Districts, Pennsylvania Dental Association.


Whipple's disease. A report of two cases and a review of the literature.


Preferential formation of antibodies specific toward D-amino acid residues upon immunization with poly-DL-peptidyl proteins.


The relation of contractile enhancement to action potential change in canine myocardium.


Nature of isoantibodies combining with human cell cultures.


Cytochemical studies on the effect of antigen on peritoneal exudate cells from guinea pigs with delayed hypersensitivity.


Studies of gamma-G red cell heteroantibodies in normal and in mononucleosis serum.


Organochlorine pesticides in the atmosphere.


Gm(g)--a "new" gamma-globulin factor.

Gm(g)--a "new" gamma-globulin factor.


Optical filtering of electron micrographs: reconstruction of one-sided images.


Rapid quantitative determination of very small amounts of proteins.


Negative staining with osmium tetroxide vapour.


Effect of isoramnetol on capillary permeability.


The macroglobulin titre in serum from patients with rheumatoid arthritis.


A new beta-adrenergic receptor blocking agent, H 56/28, in the treatment of cardiac arrhythmias.


The role of the phagocyte in host-parasite interactions. V. Phagocytic and bactericidal activities of leukocytes from patients with different neoplastic disorders.


The submicroscopic basophile structure of chromosomes in Ehrlich ascites tumor cells.


Evaluation of indomethacin by a controlled, cross-over technique in 30 patients with ankylosing spondylitis. A clinical evaluation of indomethacin employing a controlled, cross-over technique with an inert placebo was undertaken in 30 patients with ankylosing spondylitis. Patients were studied for the frequency and dose relationship of side effects and for the subjective response of morning stiffness, chronic spinal pain, acute exacerbations of pain and peripheral arthralgia. Objective evaluation assessed measured change in movements of the cervical and lumbar spines, in chest expansion and in the range of movement of involved peripheral joints.Evaluation of the results indicated that a significant number of patients experienced side effects in the form of headache and dizziness while receiving indomethacin in doses above 150 mg. per day. Many other side effects reported by the patients were not found to occur at a statistically significant level. The significance of pulmonary infections encountered in three patients was reviewed. Relief of chronic spinal pain and peripheral arthralgia occurred in 14 and 16 patients, respectively (p < 0.05). Relief of morning stiffness and acute exacerbations of pain, and increase in the range of movement of any of the segments of the spine or the involved peripheral joints were not significant (p > 0.05). Based on the results of this study, it is suggested that the role of indomethacin in the management of ankylosing spondylitis be re-evaluated and that the daily therapeutic dose of this drug which has been heretofore recommended be decreased.


Studies of bovine Mycoplasma mastitis.

Studies of bovine Mycoplasma mastitis.


On amyloidosis and paraproteinemia in seven transplantation sublines of a murine plasma cell leukemia.


The histochemistry of mucopolysaccharides.


Block staining with lead acetate.

Block staining with lead acetate.


Staining of thin sections with lead acetate.


Plasma testosterone production rates in patients with prostatic cancer and benign prostatic hypertrophy.


Effect of training with motion pictures versus flash cards upon football play recognition.


Endemic treponematoses.

Endemic treponematoses.


On the virus etiology of Duhring's disease.


Histamine in human skin. A spectrofluorometric assay.


Antimycotic effect in vitro of a detergent. Fungicidal and fungistatic effect of the detergent and its components on Trichophyton mentagrophytes. Trichophyton rubrum and Epidermophyton floccosum.


Treatment of lupus vulgaris with INH exclusively.


Ampicillin in the treatment of gonorrhoea.


The rise and fall of 19S immunological memory against sheep red cells in the mouse.


Detection of an organ specific protein in the human thymus.


Daily progestogen for contraception: a clinical study.


The variability of the auditory averaged evoked response during sleep and dreaming in children and adults.


An animal model of light sensitive epilepsy.


Experimental epilepsy induced by cobalt powder in lower brain-stem and thalamic structures.


Averaged evoked potentials and intramodality selective attention.


Maturation of the primary cortical response to stimulation of medial geniculate body.


Sleep laboratory adaptation in normal subjects and depressed patients ("first night effect").


Effect of butyrolactone and gamma-hydroxybutyrate on the EEG and sleep cycle in man.


A jacket for stimulating and recording from monkeys.


The EEG in intracranial space-occupying processes.


The value of EEG in the diagnosis of intracranial tumours.


Contributions to the EEG study of brain-stem tumours.


EEG data on acoustic neurinomas.

EEG data on acoustic neurinomas.


EEG data on some tumours of the posterior fossa (4th ventricle and cerebellum).


EEG aspects in tumours of the basal nuclei.


EEG studies in hypophyseal tumours.

EEG studies in hypophyseal tumours.


EEG value in the diagnosis of endocranial tumours.


Bioelectrical alterations in supra- and infratentorial tumours in children.


Bioelectrical alterations in midline cerebral tumours.


Serial and comparative EEG in comatose states.


EEG in temporal tumours.

EEG in temporal tumours.


Changes in impregnability of cat neocortex induced by direct stimulation and epileptic seizures.


Cortical spindles induced by single electrical stimulation of the claustrum.


The electrographic prognosis of central nervous system reactions to treatment with tuberculostatics.


Electro-clinical aspects of behavioral disorders in children.


Neocortical excitability changes induced by an ectosylvian epileptic focus.


Electro-clinical correlations in closed cranio-cerebral injuries.


Alterations of flash-evoked potentials in the visual pathway and cortex during various phases of sleep.


The recovery cycle of the auditory thalamo-cortical complex and its alterations by subcortical diffuse influences.


Reticular alteration of the recovery cycle of the somaesthetic thalamo-cortical complex.


Alterations of the recovery cycle of the somaesthetic thalamo-cortical complex by brain-stem transection and caudate lesion.


Relationships between the relay and association nuclei of the cat thalamus.


DC analysis of neocortical paroxysmal discharges projected from a hippocampal penicillin focus.


Clinical and EEG aspects in some cases of subarachnoid haemorrhage.


The association of electrodermogram (EDG) with EEG recording in the diagnosis of some neuro-endocrine disturbances.


Deep sleep phase alterations in patients with loss of the adrenal secretory rhythm and in hypophysectomized patients. (The effects of hypothalamo-hypophyseal stressing by metopyron).


Changes in the spontaneous activity of the neurones in the somato-sensory cortex by single electrical stimuli applied to the head of the caudate nucleus in the cat. Investigations with extracellular micro-electrodes.


Alterations in hippocampal activity in the rabbit in terms of blood adrenalin and cortisone levels.


Hippocampal necortical arousal dissociation under reticular and hormonal influences.


The value of EEG in post-traumatic endocranial haematoma.


EEG alterations in chronic tetany in children.


Clinical appraisal of activation with Megimide, Baytinal and alcohol in chronic alcoholism.


Electro-clinical correlations in chronic alcoholism with psychical disturbances.


Conditioned reflexes during chloralose anesthesia.


EEG data in multiple sclerosis (the pure spinal form).


EEG studies on the transmission of visual stimuli to the hippocampus.


EEG dynamics in certain chronic hepatopathies.


Consensual and opposite effects exerted by various subcortical lesions on neocortical epileptic activity.


EEG catamnesis in pseudotumoral encephalitis.


Relationships between electrographic pattern and biochemical changes after topical application of strychnine, eserine and Nembutal.


The metabolism of serotonin and the EEG in cirrhotics.


Study of the conduction velocity of peripheral motor nerve fibers in some neurological diseases.


Electroencephalographic pattern in epidemic typhus.


Electro-clinical correlations in certain non-tumoral raised intracranial pressure syndromes.


Two statistical models describing overlap between motor units.


On the origin of the Hering-Traube waves (HTW).


Prolonged recordings of spontaneous activity of single units in the hypothalamus.


Influences of antagonistic flashing on optic nystagmus.


Influences of labyrinthine and optic stimulation on hippocampal discharges.


Unit acitivity in the visual cortex during sleep and wakefulness.


Single cell responses in hypothalamus to caudate and peripheral stimuli.


The striate cortices as the true cyclopean eye.


Stimulation range of monopolar and concentric bipolar electrodes placed in a spinal motor nucleus.


Potentiation of bufotenine-like syndrome induced by diethyltryptamine in reserpinized rats.


Effect of imipramine on paradoxical sleep in newly born rabbits.


EEG activity of the olfactory bulb of the unrestrained rabbit under LSD-25 and chlorpromazine.


Effect of brain stem transections on respiratory responses to electrical stimulation of the medulla oblongata.


The effect of 5 per cent CO2 inhalation on the functional and metabolic activity of the cortex in cerveau isolé preparations.


A contribution to the understanding of anodal break excitation of nerve.


Electrode polarization effects in brain impedance measurements.


Rhythmic oscillations in amplitude of the cortical evoked potential in response to click stimuli in the anesthetized cat.


Levitation in the treatment of large-area burns.


Effects of a specific gastrin antagonist on gastric acid secretion in pouch dogs.


The twin minicoil artificial kidney.

The twin minicoil artificial kidney.


Relation between carcinoma of the bladder and infestation with Schistosoma haematobium.


Spirometry for preoperative assessment of airways resistance.


Variations in synalbumin insulin antagonism during glucose-tolerance tests.


Beta-cytotrophic effects of glucose, glucagon, and tolbutamide in man.


Insulin in bile and other body fluids.

Insulin in bile and other body fluids.


Plasma-insulin in mild juvenile diabetes.


The bacterial degradation of chloramphenicol.


Health, santé, salud.

Health, santé, salud.


Local authorities' management and staffing.


Cephalosporins.

Cephalosporins.


Diurnal rhythm in salicylate excretion.

Diurnal rhythm in salicylate excretion.


Tertiary structure of chymotrypsin.

Tertiary structure of chymotrypsin.


Epidemiology of asthma.

Epidemiology of asthma.


Employment of married women doctors in hospitals in the oxford REGION.


Autoantibodies and chromosomal aberrations.


Antibiotic-resistant streptococci.

Antibiotic-resistant streptococci.


Corticosteroids in influenza.

Corticosteroids in influenza.


A new and easy staining method for collagen and reticular fibres.


On the histophysiology of the pituitary gland in conjunction with the testicular cycle in the mahseer, Tor (Barbus) tor (Ham.).


Neurosecretory activity in the brain of the water-beetle, Dytiscus marginalis.


Pharmacological studies of a new series of bicyclic thymoleptics.


A colorimetric method for the quantitative determination of thiazolidine-4-carboxylic acids.


Studies on the mechanism of nidation. XX. Relation of histamine release to estrogen action in the progestational rat.


Increased total thyroxine with normal free thyroxine in antithyroid antiserum.


Interactions of Shope papilloma virus and rabbit skin cells in vitro. I. Immunofluorescent localization of virus inocula.


Chronic lymphadenopathy simulating malignant lymphoma.


Early detection of oral cancer by application of four methods.


Embryogenesis in Hymenolepis diminuta. II. Glycogen distribution in the embryos.


Purification and characterization of the 2 S-gamma-2-globulin of normal human plasma.


Structural studies of the immunoglobulins. IV. Heavy and light chains of the gamma-M pathological macroglobulins.


Ultrastructure and cytochemistry of metabolic DNA in Tipula. A DNA body is present in the females of the fly Tipula oleracea and is formed in contact with the sex chromosomes in the oogonial interphases. At each oogonial mitosis, the DNA body follows the chromosomes to one anaphase group and is included in one of the telophase nuclei. The body increases appreciably in size during the interphase of meiosis. All oocytes have the body, but only a few nurse cells possess it. The DNA body synthesizes its DNA at a different time than the chromosomes, as is shown by incorporation of tritiated thymidine, and contains 59% of the DNA of the nucleus, as is disclosed by spectrophotometric measurements. At late diplotene the DNA body disintegrates, releasing its DNA into either the nucleus or the cytoplasm. When studied in the electron microscope, the DNA body appears composed of a tight mass of intertwined fibrils. Demonstration that the main mass of the body is composed of DNA is obtained from cytochemical tests which reveal that the DNA body is Feulgen positive, stains green with azure B, incorporates H(3)-thymidine, and after digestion with DNase is Feulgen negative. The DNA of the body is complexed with histone, like the DNA of the chromosomes, as is revealed by an intense alkaline fast green staining. Electron microscope examination of oocytes reveals that one side of the DNA body is in close contact with the nuclear envelope and that the other side possesses an outer shell composed mainly of particles 150 to 250 A in diameter. Between the outer shell and the chromosomes there is a band of low electron opacity, 4000 to 7000 A thick. In the light microscope, this light band together with the outer shell is Feulgen negative and stains violet with azure B; this is confirmation of the presence of RNA. In the oocytes the nucleoli are found inside the DNA body. These nucleoli have a nucleolonema composed mainly of particles 150 to 250 A. The nucleoli are Feulgen negative, alkaline fast green negative, stain violet with azure B, and do not stain with azure B after RNase digestion, thus confirming their RNA content. The presence of the nucleoli inside the DNA body and of a band of RNA between the body and the chromosomes is indicative of a high RNA synthetic activity. Since the DNA of the body is complexed with histone, as in the chromosomes, and the nucleoli are located inside the body, the simplest interpretation of the DNA body is that it represents hundreds of copies of the operons of the nucleolar organizing region or neighboring regions. The situation found in Tipula has several basic features in common with the polytene chromosomes of other Diptera and with the hundreds of nucleoli present in Triturus oocytes. In all three cases, genes seem to be copied hundreds of times but are kept in different types of packages. A DNA body like the one in Tipula oleracea is found in other species of Diptera and in the Coleoptera. There is no indication, from the present investigation, that the DNA body is in any way associated with a virus.


The fine structure of elastic fibers.

The fine structure of elastic fibers. The fine structure of developing elastic fibers in bovine ligamentum nuchae and rat flexor digital tendon was examined. Elastic fibers were found to contain two distinct morphologic components in sections stained with uranyl acetate and lead. These components are 100 A fibrils and a central, almost amorphous nonstaining area. During development, the first identifiable elastic fibers are composed of aggregates of fine fibrils approximately 100 A in diameter. With advancing age, somewhat amorphous regions appear surrounded by these fibrils. These regions increase in prominence until in mature elastic fibers they are the predominant structure surrounded by a mantle of 100 A fibrils. Specific staining characteristics for each of the two components of the elastic fiber as well as for the collagen fibrils in these tissues can be demonstrated after staining with lead, uranyl acetate, or phosphotungstic acid. The 100 A fibrils stain with both uranyl acetate and lead, whereas the central regions of the elastic fibers stain only with phosphotungstic acid. Collagen fibrils stain with uranyl acetate or phosphotungstic acid, but not with lead. These staining reactions imply either a chemical or an organizational difference in these structures. The significance and possible nature of the two morphologic components of the elastic fiber remain to be elucidated.


Physical studies of phospholipids. 3. Electron microscope studies of some pure fully saturated 2,3-diacyl-DL-phosphatidyl-ethanolamines and phosphatidyl-cholines. On heating pure, fully saturated 2,3-diacyl-DL-phosphatidyl-ethanolamines and 2,3-diacylphosphatidyl-cholines (lecithins) in water to the transition temperature at which large endothermic heat changes occur, they are observed, by light microscopy, to form myelin figures. This result is discussed in terms of the large difference in the transition temperature for "melting" of the hydrocarbon chains of unsaturated and saturated phospholipids and is illustrated by means of differential thermal analysis (D.T.A.) curves. These structures have been examined by electron microscopy after negative staining and after reaction with osmium tetroxide. Typical phospholipid lamella structures are seen in the phosphatidylcholines after negative staining, and in the phosphatidyl-ethanolamines after both negative staining and osmium fixation. The distances across these lamellae have been measured. Some preliminary investigations of the nature of the osmium tetroxide reaction with the phosphatidyl-ethanolamines have been made.


Changes in the concentrations of the gamma-c-globulin and the gamma G-globulin of bovine cerebrospinal fluid with maturation.


Current cancer concepts. Hypophysectomy as palliative treatment.


Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis.


Effect of low-molecular-weight dextran on postoperative renal function.


Folic-acid deficiency in chronic arsenic poisoning.


Fibrinolysis in pulmonary vascular disease.


Serum beta-glucuronidase, glucose tolerance, and atherosclerotic disease.


The first drink.

The first drink.


Classification of chronic bronchitis.

Classification of chronic bronchitis.


Dreaming.

Dreaming.


Cancer research.

Cancer research.


No more jelly?

No more jelly?


Pre-employment medical examination.

Pre-employment medical examination.


Terminal cancer at home.

Terminal cancer at home.


Clinical teaching in the United States.

Clinical teaching in the United States.


Psychiatric consultation in general practice.


A basic misunderstanding.

A basic misunderstanding.


Heroin and cocaine addiction.

Heroin and cocaine addiction.


The speaking-aid.

The speaking-aid.


Medicine in Bhutan.

Medicine in Bhutan.


Gastrin.

Gastrin.


Treatment of leukaemia by aminoacid imbalance.


Treatment of multiple sclerosis with tranylcypromine.


Acute renal failure associated with sulthiame.


Mucopolysaccharides in amyloidosis.

Mucopolysaccharides in amyloidosis.


A ring X chromosome in dwarfism.

A ring X chromosome in dwarfism.


Chromosome abnormalities, neoplasia, and autoimmune disease.


Phosphokinase activity of erythrocytes in mongolism.


Reaction to chlorhexidine and cetrimide.


Electrocardiographic abnormalities associated with subarachnoid hemorrhage.


Bacteraemic shock due to gram-negative bacilli.


Testosterone and blood fibrinolytic activity.


Immunological aspects of trophoblast activity.


Thrombosis in women of child-bearing age.


Immunological studies in experimental allergic encephalomyelitis and in multiple sclerosis with special reference to pathogenesis and diagnosis.


Nature of vesicles associated with the nervous system of cephalopods.


The disulphide bridges of immunoglobulin kappa-chains. The arrangement of the disulphide bridges of the major component of the light chains of immunoglobulins (kappa-chains) has been studied in the Bence-Jones proteins. Three disulphide bridges have been found. An interchain bridge at the C-terminus has been shown to occur in the dimers of all the proteins studied and was characterized by symmetrical peptides. In the monomer form, the C-terminal half-cystine of the corresponding peptides was linked to a lone half-cystine residue. A second common disulphide-bridge peptide in which a single amino acid difference could be related to the Inv factors of the individual proteins was found in Bence-Jones proteins and in the kappa-chains of normal and abnormal immunoglobulins. Peptides characteristic of a third disulphide bridge studied in three specimens were found to have differences in some residues, but also striking similarities. A methionine peptide has also been characterized in two specimens as a by-product of the technique employed. It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.


Immunoglobulin kappa-chains. Comparative sequences in selected stretches of Bence-Jones proteins. Three type K Bence-Jones proteins have been fully reduced and carboxymethylated with high-specific-activity iodo[(14)C]acetate. A tryptic digest and a chymotryptic digest of each protein were fractionated on a Sephadex column and the radioactive peptides were purified by paper electrophoresis. All the proteins studied had five unique carboxymethylated cysteine sequences. Three of these were identical with the exception of a single substitution, and two had some variations. The common peptides could be placed in the C-terminal half of the molecule. The variations around the other two half-cysteine residues provided information about the nature of the variability of the primary sequence of immunoglobulin kappa-chains. The results are consistent with the hypothesis that the chains derive from a common ancestor by somatic mutation of a small number of genes or by gene doubling and selection in the course of evolution. The isolation of the N-terminal peptide in methionine-containing Bence-Jones proteins is also described.


Quantitative immunoglobulin levels (IgG, IgA and IgM) in children, determined by the Hyland Immunoplate technique. Quantitative immunoglobulin levels (IgG, IgA and IgM) were determined in 200 infants and children ranging in age from 2 months to 15 years, using the Hyland "Immunoplate" technique. The mean values obtained ranged from 346 mg. % for IgG in the youngest age group to 814 mg. % in the oldest; for IgA the mean values ranged from 49 mg. % in the youngest age group to 114 mg. % in the oldest; for IgM the mean values ranged from 47 mg. % in the youngest age group to 97 mg. % in the oldest age group. The method used proved to be reproducible from day to day and was much more rapid than a previously used double-diffusion technique.


LATS production by lymphocyte culture in patients with Graves' disease.


Determination of the thyroxine iodine content of serum contaminated by organic iodines. A method based on gel filtration.


Close linkage in genes controlling gamma-A and gamma-G heavy chain structure in BALB/c mice.


Significance of carbon monoxide as an air pollutant.


Immunological aspects of malignant disease.


A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.


Allergenic residues in penicillins.

Allergenic residues in penicillins.


Cutaneous sensitivity to purified benzylpenicillin.


Peritoneal dialysis in hypercatabolic acute renal failure.


Return to normal of the electrocardiogram after myocardial infarction.


Effect of salicylate infusion on plasma-insulin and glucose tolerance in healthy persons and mild diabetics.


Electrolyte replacement in paediatric cholera.


Development areas in the hospital service.


Fibrinolysis and urolithiasis.

Fibrinolysis and urolithiasis.


Hypertrophic neuropathy.

Hypertrophic neuropathy.


Hypersensitivity to penicillin.

Hypersensitivity to penicillin.


An ABC of modern immunology. 8. Defects and evasions.


A survey of surgical management of lumbar disc prolapse in the United Kingdom and Erie.


Cutaneous anthrax.

Cutaneous anthrax.


A classification of tetanus.

A classification of tetanus.


Money and medicine.

Money and medicine.


Inheritance of atrial septal defect.

Inheritance of atrial septal defect.


Persistence of aortic-valve homografts.

Persistence of aortic-valve homografts.


XO-XX-XXX mosaicism with Turner stigmata.


Azauridine in viral eye infections.

Azauridine in viral eye infections.


Radiation myopathy.

Radiation myopathy.


150 Patients with cardiac infarction treated in a coronary unit.


Immunoglobulins in saliva and serum in dental caries.


Ferrous sulphate with ascorbic acid in iron-deficiency anaemia.


Effect of caffeine versus placebo supplementation on blood-glucose concentration.


Gastric fibrinolysis. A possible aetiological link with peptic ulcer.


An automatic peritoneal dialysis system.


A simple and efficient method of separating peripheral-blood leucocytes for in-vitro studies.


Isotope uptake and scanning of stomach in man with 99mTc-pertechnetate.


Who teaches our teachers?

Who teaches our teachers?


Narcotic antagonists.

Narcotic antagonists.


Control of the asbestos hazard.

Control of the asbestos hazard.


Morbidity and social class.

Morbidity and social class.


University medical staff.

University medical staff.


Hemiplegia in a diabetic producing unilateral peripheral neuritis and hypoglycaemic attacks.


Gastroferrin and iron-deficiency anaemia.


Thyroid hormone and calcium metabolism.

Thyroid hormone and calcium metabolism.


Peritoneal dialysis in renal failure.

Peritoneal dialysis in renal failure.


Peritoneal dialysis in hypercatabolic acute renal failure.


Breast cancer and heredity.

Breast cancer and heredity.


Classifying protein-calorie malnutrition.


Aminoacid loss in peritoneal dialysis.

Aminoacid loss in peritoneal dialysis.


Familial alpha-lipoprotein deficiency (Tangier disease) with neurological abnormalities.


Oestrogen treatment of recurrent aphthous mouth ulcers.


Serum-cholesterol and capacity for physical work of middle-aged sedentary males.


Cytomegalovirus hepatitis in the adult.

Cytomegalovirus hepatitis in the adult.


Relation between urinary calcium and sodium in patients with idiopathic hypercalciuria.


Effect of vasopressin on serum-levels of human growth hormone.


Isolation of a virus from Burkitt lymphoma cells.


Metabolic anomalies in porphyria. The result of impaired biological oxidation?


Plasma levels of ionised calcium and magnesium in thyroid disease.


A pneumatic pressure-transducer.

A pneumatic pressure-transducer.


Standards of obstetric care.

Standards of obstetric care.


Blood group and stomal ulcer.

Blood group and stomal ulcer.


Techniques of renal biopsy.

Techniques of renal biopsy.


Self-treatment as an alternative to rationing of medical care.


West Indian one-year-olds. A comparative analysis of health and service utilisation.


Measles virus and panencephalitis.

Measles virus and panencephalitis.


Magnesium-deficiency thrombosis.

Magnesium-deficiency thrombosis.


Peritoneal dialysis in renal failure.

Peritoneal dialysis in renal failure.


Hematological effects of oral contraceptives.


Frusemide in acute pulmonary oedema.

Frusemide in acute pulmonary oedema.


Absence of the thymus.

Absence of the thymus.


A sign of chromosomal aberration?

A sign of chromosomal aberration?


Ultrastructure of Cowdry type A inclusions. 1. In human herpes simplex encephalitis.


Heterogeneous system degeneration of the central nervous system associated with peripheral neuropathy.


The influence of the plasma inorganic iodine concentration on thyroid function in dehalogenase deficiency.


Hypertrophied plasma cells in regional enteritis.


Hyperthyroidism and steatorrhea in an adolescent. Report of a case.


Chromatographic subfractionation and characterization of Cohn's fraction 3 from human palsma.


Dependence of fetal PBI and cholesterol on maternal values.


Education in orthodontics for the general practitioner.


The periodontal status of incoming Air Force Academy cadets.


Studies with cultured brown adipose tissue. 3. A cytochemical study of rabies virus inclusion bodies.


Pigeon breeder's lung in children.

Pigeon breeder's lung in children.


Plasma cells in the circulation in infants and children.


Thymic alymphoplasia with immunoglobulin synthesis.


Effect of estrogen, thyroxin, and their combination on dental caries and salivary glands in ovariectomized and intact female rats.


Effects of radioprotective chemicals on the histopathologic changes of oral radiation death in mice.


Similarities of keratinization and amelogenesis.


The clearing factor lipase (CFL) response to synthetic sulfonated polysaccharides in the rat.


Hyaline bodies in odontogenic cysts: a histochemical study for hemoglobin.


Presence of lipids in keratohyalin granules of human gingiva.


Demonstration of auto-immune antiliver antibodies in the sera of patients suffering from cirrhosis of liver.


Technique of bilateral palliative adrenalectomy.


A modification of Cajal's gold-sublimate method for tissue fixed in formalin.


Effect of Echis colorata venom inoculation on the nervous system of the dog and guinea pig.


Antinuclear factors in nephrotic syndrome secondary to systemic lupus erythematosus and in leprosy.


Chemical characterization of fluorescein isothiocyanate-protein conjugates.


Antibodies against staphylococcal teichoic acids and type-specific antigens in man.


The effect of kaolin on immunoglobulins: an improved technique to remove the nonspecific serum inhibitor of reovirus hemagglutination.


"Protein A" from Staphylococcus aureus. II. Arthus-like reaction produced in rabbits by interaction of protein A and human gamma-globulin.


Factors affecting the degree of nonspecific staining given by fluorescein isothiocyanate labelled globulins.


Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin.


Antigenic analysis of a metazoan parasite, Toxocara canis. II. Purification and analysis of two antigenic components.


On the virus etiology of keratoacanthoma.


Psoriasis. A statistical, clinical and laboratory investigation of 255 psoriatics and matched healthy controls.


Occurrence of Trichophyton mentagrophytes var. asteroid. On hairs of guinea pigs with ringworm lesions.


Cryoglobulinemia and porphyria hepatica chronica (porphyria cutanea tarda).


Notation for human immunogobulin subclasses. After consultation between immunologists from a number of countries a nomenclature for human immunoglobulins was proposed in 1964 and was published in the Bulletin of the World Health Organization.(1) However, that proposed scheme of notation, which has already gained wide acceptance, left several specialized areas of nomenclature still to be resolved; one of these was the subclasses of immunoglobulins. Some of the research workers most closely concerned with the problem have now agreed upon a unified scheme for the notation of the human immunoglobulin subclasses, and, in particular, of the immunoglobulin G subclass, for which two different nomenclatorial schemes have been followed in recent years. Their proposals are given below.


Measles vaccination in Iceland: three-year follow-up of antibody titres in adults and children.


An EEG aspect of the mechanism of visual adaptation.


EEG and gamma-EG correlations in the diagnosis of brain tumours.


In vitro vital staining of chelonian blastoderms.


A single-patient haemodialysis-monitoring and dialysate-proportionating machine.


Location of nucleic acids by electron probe x-ray microanalysis.


Histamine release in guinea pig anaphylaxis. II. Inhibiting effect of specific versus nonspecific (peptone) desensitization.


Fine structural study of a possible mechanism of secretion by the interrenal cells of the brown pelican.


The development of renal lesions in NZB-NZW mice immunohistological studies.


Results of treatment of cancer of the female breast in a community general hospital.


Spontaneous regression of pulmonary metastases following palliative nephrectomy. Case report.


The influence of tracer doses of radio-iodine on the level of protein-bound iodine in serum.


Hypercupremia in a patient with multiple myeloma.


An evaluation of methacycline hydrochloride (6 methylene oxytetracycline).


Effect on guinea pigs of intratracheally administered Ziehl--Neelsen positive pollens. (Data concerning the aetiological correlation between pollen granulomata and sarcoidosis).


Catabolism of albumin and gamma globulin after treatment with ionising radiation to the abdomen.


Histochemistry and biophysical histology of the matrices of some mineralized tissues.


A chromosome translocation in association with periarteritis nodosa and macroglobulinemia.


A "monoclonal" type, low molecular weight protein related to gamma-M-macroglobulins.


Mass screening for hypothyroidism by the achilles reflex time.


A light and electron microscopical study of collagen degeneration.


Microbial metabolism of actinomycins and other heterodetic antibiotic peptides.


Influence of antisera from histoincompatible mice on electrophoretic mobility of EL4 tumor cells.


Thyrotrophic hormone secretion in rats after partial or total interruption of nueral afferents to the medial basal hypothalamus.


Metabolic control mechanisms in mammalian systems. I. Hormonal induction of phosphofructokinase in the rat uterus.


Dissociation, reaggregation, and subunit structure studies of some human gamma-M-globulins.


Electrophoresis of bovine serum at acid pH.


Community medical television system dedicated.


Breast cancer and heredity.

Breast cancer and heredity.


Clinical and serological profiles in leprosy.


Clinical effects of xylitol on carbohydrate and lipid metabolism in diabetes.


Nephrotic syndrome associated with bacteraemia after shunt operations for hydrocephalus.


A new method of measuring blood-pressure in mice.


Effect of ethylchlorophenoxyisobutyrate on weight, plasma volume, total body-water, and free fatty acids.


Blood-lymphocytes in newborn and adult.

Blood-lymphocytes in newborn and adult.


Abnormal histidine metabolism in thyrotoxicosis in man. A possible index of impaired folate function.


Responsibility after gastrectomy.

Responsibility after gastrectomy.


Synthetic foods and deficiency states.

Synthetic foods and deficiency states.


Imported ills.

Imported ills.


Respiratory virus infections.

Respiratory virus infections.


Teaching about cancer.

Teaching about cancer.


Designing for road safety.

Designing for road safety.


Medical research.

Medical research.


Preventive medicine and the gastrectomised patient.


Doctors as witnesses.

Doctors as witnesses.


pH during exchange transfusion.

pH during exchange transfusion.


Homograft interaction.

Homograft interaction.


Response of lymphocytes to tetracycline.


Smoking obscured.

Smoking obscured.


Carcinoma of bronchus.

Carcinoma of bronchus.


Insulin secretion and glucagon.

Insulin secretion and glucagon.


A new axis-deviation calculator.

A new axis-deviation calculator.


Paediatrics and the undergraduate curriculum.


"Mint sweets" and dental caries.

"Mint sweets" and dental caries.


Foetal sex in antepartum haemorrhage.

Foetal sex in antepartum haemorrhage.


Patients waiting.

Patients waiting.


Cryoprecipitable proteins in sickle-cell anaemia.


The thymus and autoimmunity.

The thymus and autoimmunity.


Comparison of hydroxocobalamin and cyanocobalamin in the treatment of pernicious anaemia.


Physical fitness and immunity to heart-disease in Masai.


Plasma-renin and aldosterone secretion in hypertensive patients with renal or renal artery lesions.


Neuropathy in the diabetic and non-diabetic populations.


Encephalitis after the reduction of steroid maintenance therapy.


Bicarbonate therapy during embolectomy. Prevention of acidosis shock and acidosis arrest.


Improvement in bronchial asthma not reflected in forced expiratory volume.


Pseudomonas aeruginosa cross-infection due to contaminated respiratory apparatus.


Aminogenic alopecia. Loss of hair associated with argininosuccinic aciduria.


Renal excretion of hydroxocobalamin in man.


Medical schools: more or bigger?

Medical schools: more or bigger?


The mnemon.

The mnemon.


Pigeons.

Pigeons.


Neuropathology of acute intermittent porphyria.


The practice of neuropathology, past, present and future.


Those awards.

Those awards.


Central sterile supply.

Central sterile supply.


Liver metabolism and contraceptive steroids.


Oral contraceptives and thromboembolic episodes.


XX/XY lymphoid chimaerism.

XX/XY lymphoid chimaerism.


Chédiak-Higashi syndrome.

Chédiak-Higashi syndrome.


Australian Health Service costs.

Australian Health Service costs.


Osteomalacia after gastrectomy.

Osteomalacia after gastrectomy.


Profiles in leprosy.

Profiles in leprosy.


Colour-blindness and alcohol addiction.

Colour-blindness and alcohol addiction.


Renin in diabetes insipidus.

Renin in diabetes insipidus.


Research in subnormality hospitals.

Research in subnormality hospitals.


Systemic lupus erythematosus with circulating anticoagulant discovered after postextraction hemorrhage.


Some altered gastric mucins associated with esophagogastric ulcers in swine.


Physiologic responses of ruminants to toxic factors extracted from rumen bacteria and rumen fluid.


Hyper-gamma M-globulinemia in experimental anaplasmosis.


Measurements of oxidoreduction processes AND ATP levels in an isolated crustacean neuron.


Serum proteins in Huntington's chorea.

Serum proteins in Huntington's chorea.


Detection of histamine by a new fluorescent omicron-phthalaldehyde stain.


Histochemical acylation of aldehydes produced by periodic acid oxidation.


Use of the direct-coloring thiocholine technique for demonstration of intracellular neuronal cholinesterases.


Identification of two fowl beta-macroglobulins with precipitating antibody activity.


Antibody formation and experimentally induced chimerism in very young rabbits.


Interference with the determination of aldrin and benzene hexachloride residues by gas chromatography.


Goitrogenic activity of onion volatiles.


Investigations into sex dimorphism during nuclear interphase of the argasid tick, Ornithodoros savignyi (Audouin, 1827).


Observations on a strain of bluetongue virus by electron microscopy.


New psychological conceptions of memory.


Polyribosomal synthesis and assembly of the H and L chains of gamma globulin.


Thyroxine utilization in non-pregnant, steroid-induced pseudopregnant, and pregnant monkeys.


Seasonal changes in serum lipids and proteins in the 13-lined ground squirrel.


Effects of beta-adrenergic receptor blockade in normal subjects before, during, and after triiodothyronine-induced hypermetabolism.


Preferential staining of collagen by acid dyes in methanol.


Intracellular plasma protein: a manifestation of cell injury in myocardial ischemia.


Effects of (plus or minus)-5-vinyl-2-oxazolidinethione, a goitrogen in rapeseed meal, on the rate of growth and thyroid function of chicks.


Metrial gland and other glycogen containing cells in the mouse uterus following mating and through implantation of the embryo.


Biochemical effects of prednisolone on human liver cells in tissue culture.


Cerebral metabolism during epileptic seizures in man.


Cerebral somatosensory responses evoked during sleep in man.


Visually evoked responses in migraine.

Visually evoked responses in migraine.


The hippocampal electrical correlates of the homeostatic regulation of motivation.


A study on the duration of cortical after-discharge in the cat.


The electroencephalogram in three cases of periodic psychosis.


Correlation between electroencephalography and angiography in cerebrovascular accidents.


Status of the segmental innervation in thyrotoxic periodic paralysis.


Intramuscular methohexital for rapid induction of short duration sleep in the EEG laboratory: a study of forty-four hyperkinetic children.


EEG in prediction of Huntington's chorea. An eighteen year follow-up.


Thermoelectric freezing stage for serial brain sectioning.


A system for selection of responses for averaging.


Gas chromatographic analysis of histamine metabolites in urine. Quantitative determination of ring methylated imidazoleacetic acids in healthy man.


Descending hypothalamic medullary pathways in the cat.


Morphological changes occurring in the developing chick choroid plexus.


Projections from the fornix to the hippocampal formation in the squirrel monkey.


Synthesis of potential antineoplastic agents. XIV. Some 2-substituted 2,3-dihydro-1h-perimidines.


Number of nucleoli in various cell types of the mouse.


A pharmacologic comparison of norethindrone and chlormadinone acetate.


A comparative investigation of neuroglia in representative vertebrates: a silver carbonate study.


Quantitative determination of serum immunoglobulins in various diseases.


Light and electron microscopic observations in a superficial corneal dystrophy probable early Reis-Bücklers' type.


Hemorrhage in hyaline bodies (drusen) of the optic disc during an attack of migraine.


The psychobiology of racial violence.

The psychobiology of racial violence.


Ora serrata pearls. Clinical and histological correlation.


Neuropathy in Tangier disease. Alpha-Lipoprotein deficiency manifesting as familial recurrent neuropathy and intestinal lipid storage.


Mechanism by which certain dietary substances interfere with the peripheral activity of thyroxine.


Effect of goitrin analogues and related compounds on the rat thyroid gland.


Antibodies in human sera to rabbit erythrocytes.


Antibodies of IgA and IgG class in normal human urine.


Body-image symbols of repression.

Body-image symbols of repression.


Past ego states emerging in hypnoanalysis.


Infectivity and antigenicity of streptomycin-dependent Salmonella typhosa.


The influence of the route of administration of Newcastle disease virus on host response. II. Studies on artificial passive immunity.


Neonatal infections with Pseudomonas aeruginosa associated with contaminated resuscitation equipment.


Obstetrics in developing countries.

Obstetrics in developing countries.


Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea.


Ruptured intracranial aneurysm. Clinical series.


Ruptured intracranial aneurysm. Community study.


Stimulation of glucagon secretion by oral glucose.


Effect of adrenergic beta-blockade on parkinsonian tremor.


Tonsillectomy and multiple sclerosis.

Tonsillectomy and multiple sclerosis.


Radioactive method for the measurement of lymphocyte transformation in vitrol.


Cytomegalovirus infection in the newborn and in early childhood. Three atypical cases.


Effect of red blood-cells and adenosine on platelet adhesiveness.


Low-molecular-weight dextran in treatment of bone-pain crises in sickle-cell disease. A double-blind trial.


Water hemlock poisoning.

Water hemlock poisoning.


Heterologous aortic valve transplantation.


Neurogenic effects of angiotensin.

Neurogenic effects of angiotensin.


Absorption of vitamin B 12 in the rat.

Absorption of vitamin B 12 in the rat.


Objective measurement of parkinsonian tremor.


Memory molecules.

Memory molecules.


Gastric ulcer or gastric cancer?

Gastric ulcer or gastric cancer?


How many alcoholics?

How many alcoholics?


Effect of transplantation immunity on lymphocyte cultures.


Achalasia.

Achalasia.


Thumping the precordium.

Thumping the precordium.


A parent's voice.

A parent's voice.


Drug addiction.

Drug addiction.


Unrecognised alcoholism.

Unrecognised alcoholism.


Smoking obscured.

Smoking obscured.


Pesticides and food additives.

Pesticides and food additives.


Laryngectomy in management of dysphagia.


Familial Guillain-Barré syndrome.

Familial Guillain-Barré syndrome.


Platelets in multiple sclerosis.

Platelets in multiple sclerosis.


Thiazides and cerebral ischaemia.

Thiazides and cerebral ischaemia.


Tetanus prophylaxis.

Tetanus prophylaxis.


Responsibility after gastrectomy.

Responsibility after gastrectomy.


Diazepam in intravenous anesthesia.

Diazepam in intravenous anesthesia.


Chromosome in chronic lymphatic leukaemia.


Chromosomes in premyeloid leukaemia.

Chromosomes in premyeloid leukaemia.


Induced allergic encephalomyelitis.

Induced allergic encephalomyelitis.


Cardiomyopathies: recruits step forward.


Effects of atropine on heart-rate in healthy man.


Thyrotoxicosis and Hashimoto goitre in a pair of monozygotic twins with serum long-acting thyroid stimulator.


Spontaneous bruising associated with a defect in the interaction of platelets with connective tissue.


Empirical or rational? The nature and basis of psychiatry.


In-vivo effects of the synalbumin insulin antagonist and of B-chain albumin.


Effects of adrenaline and of smoking in patients with peripheral atherosclerotic vascular disease.


Significance of variation in satellite incidence in normal human mitotic chromosomes.


Lymph-node permeability factor in human synovial tissue as a possible mediator of chronic joint inflammation.


Rheumatic heart-disease.

Rheumatic heart-disease.


Prevention of cancer.

Prevention of cancer.


Psychiatric beds.

Psychiatric beds.


Minding and fostering.

Minding and fostering.


Dandruff.

Dandruff.


Safety in the animal house.

Safety in the animal house.


Nutrition research in India.

Nutrition research in India.


Hip fractures in the elderly.

Hip fractures in the elderly.


Planning a new medical school.

Planning a new medical school.


Mothers in hospital. The nurse's viewpoint.


An epidemic of acute nodular goitre.

An epidemic of acute nodular goitre.


Chloramphenicol in renal disease.

Chloramphenicol in renal disease.


Recurrent aphthous ulcers.

Recurrent aphthous ulcers.


Tracheostomy and artificial ventilation in chronic lung disease.


Metabolic effects of autonomic blockade.


Oral contraceptives and depression.

Oral contraceptives and depression.


The sequence of events in neonatal apnoea.


Ileostomy and excision of the large intestine for ulcerative colitis.


Cadaveric renal transplantation.

Cadaveric renal transplantation.


Cell culture and the Chediak-Higashi syndrome.


Stimulation of gastric-acid secretion by histamine, pentagastrin, and pentagastrin-propantheline after vagotomy in man.


Extracellular volume in patients with chronic renal disease treated for hypertension by sodium restriction.


Treatment of dracontiasis with niridazole.


Pulmonary surface tension and pathological changes in infants dying after respirator treatment for severe hyaline membrane disease.


Intrinsic-factor antibody in diabetes mellitus.


Childbirth chills are they an immunological reaction?


New device for determining direction of cardiac vectors.


Screening and practice of medicine.

Screening and practice of medicine.


Circulating cancer cells.

Circulating cancer cells.


Cancer of the cervix.

Cancer of the cervix.


The mystique of the barium meal.

The mystique of the barium meal.


Delayed in hospital.

Delayed in hospital.


Virus-like particles in cardiac biopsy.

Virus-like particles in cardiac biopsy.


Haemolytic anaemia after nalidixic acid.


Achilles tendon reflex to evaluate thyroid function during pregnancy and in subjects taking oral contraceptives.


Passive cutaneous anaphylaxis induced in mice with rabbit 5S antibody fragaments.


Role of aggregated bovine albumin in pathogenesis of serum sickness nephritis in rabbits.


Adaptation of the hemolytic plaque technique for enumeration of immune cells responding to heterologous immunoglobulin antigens.


Immunoglobulin classes of serum neutralizing antibody formed in response to infection with human A2 influenza virus.


Detection of five components having antibody activity in rat antisera.


Experimental "hydralazine erythematodes" of the guinea pig.


Joint involvement in systemic lupus erythematosus and in scleroderma (systemic sclerosis).


Mechanism of cardiac valvular fusion and stenosis.


Terminal axonal patterns in cat spinal cord. I. The lateral corticospinal tract.


Results of combined treatment in patients with cancer of the stomach: palliative gastrectomy, large-dose Mitomycin-C, and bone marrow transplantation.


Carcinogenesis in the esophagus. 3. Polycyclic aromatic hydrocarbons and phenols in whisky.


Some technical improvements in the paper chromatography of sugars. A method of sample desalting and a sensitive staining reagent.


Cellular heterogeneity in the production of an anti-hapten antibody. Single lymph node cells from rats immunized with a conjugate of 3-iodo-4-hydroxy-5-nitrophenyl acetic acid chloride (NIP) and chicken globulin were tested against either NIP or NNP conjugated with bacteriophage. NNP is related to NIP but has a nitro group instead of iodine. The conjugated phages were still infective but easily inactivated by anti-hapten sera at a serum concentration of 10(-7). Phages carrying a related hapten were less sensitive to antibody than phages conjugated with the immunogenic hapten. When NIP-T2 and NNP-T4 conjugates were incubated in microdrops containing a single lymph node cell from an anti-NIP animal, strong inactivation of either or both phages occurred in some cases. For the reasons given in the text this inactivation was considered to be due to anti-NIP antibody produced by the cell in the microdrop. Inactivation of the two kinds of phages by the anti-NIP cells was highly nonrandom; some cells inactivated almost all of the 1700 or so NIP-T2 phages in the drop but left almost all NNP-T4 phages viable. Others had a very strong cross-reaction and inactivated equal proportions (up to 75%) of both phages. The remaining active cells exhibited an intermediate degree of cross-reaction. Control experiments indicated that there was a true cellular heterogeneity in the specificity of the anti-NIP produced by different cells. They suggested that the observed heterogeneity of specificities was limited to the structure of the hapten and was not influenced by the structure of the carrier. As all the cells studied were induced by a single hapten, the observed cellular heterogeneity was probably not caused by a heterogeneous antigen. It seems more likely that latent heterogeneity was present in the cells before they were stimulated by the NIP hapten.


Alteration of the response of platelets to surface stimuli by pyrazole compounds. Sulfinpyrazone and phenylbutazone block the aggregating action of collagen, antigen-antibody complexes, and gamma globulin-coated surfaces on blood platelets. These drugs do not block the action of ADP or thrombin. Inhibition of surface-induced aggregation appears to be the result of a decreased response of the platelets to surface stimuli, giving rise to diminished release of platelet constituents, such as ADP and serotonin. The intravenous infusion of these drugs produced results similar to those found in the in vitro experiments. Administration of phenylbutazone in doses sufficient to produce marked suppression of the platelet-collagen reaction impaired hemostatic plug formation at the ends of transected mesenteric vessels in rabbits. Since platelet function is considered a factor influencing platelet survival, the effect of phenylbutazone on platelet survival was examined. It was found that phenylbutazone prolonged platelet survival to more than twice the normal time and reduced platelet turnover by nearly 50%. These studies show that drugs which suppress platelet response to surface stimuli alter platelet function in vivo.


Studies on the control of antibody synthesis. Interaction of antigenic competition and suppression of antibody formation by passive antibody on the immune response. In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.


The quantitation of nonspecific staining as a guide for improvement of fluorescent antibody conjugates.


Inhibition of the biosynthesis of steviol by a growth retardant.


Experimental cerebral edema: enzyme-histochemical study.


Carcinogens in a cracked petroleum residuum. The contributions of various polycyclic aromatic hydrocarbons to the carcinogenic potency of a catalytically cracked oil.


Inadequate automobile control but more horsepower, more chrome, and more red herring.


Studies on blood vascular silver-blackened fibers (SF, BSF) related to heart beat and vascular phenomenon in vertebrates. IV. Electron-microscopical structure of silver-blackened fibers(SF) of the heart.


The N-terminal sequence of the heavy chain of rabbit immunoglobulin IgG. The absence of an N-terminal amino acid with a free alpha-amino group from the heavy chain of rabbit immunoglobulin IgG has been confirmed and no evidence could be found of a blocking formyl, acetyl or propionyl group. The N-terminal amino acid appears to be pyrrolid-2-one-5-carboxylic acid (PCA) in all molecules. A mixed amino acid sequence follows in the approximate proportions: PCA-Ser-Val-Glu-Glu-Ser-Gly-Gly-Arg, 50%; PCA-Ser-Leu-Glu, 20%; PCA-Glu(NH(2)), 20%. The heavy chains of a purified antibody, namely anti-(human serum albumin), and of immunoglobulin IgG from a rabbit homozygous at the allotypic loci both showed a similar mixed N-terminal sequence.


Improved technique for separation and identification of bovine beta globulins by starch-gel electrophoresis.