Fluorescent-antibody approach to study of rhizobia in soil. Application of fluorescent-antibody (FA) techniques to the study of rhizobia as free-living soil bacteria was explored. Antiserum to a particular strain of Rhizobium japonicum proved specific in both agglutination and FA tests. Within the R. japonicum group, 2 of 12 strains were stained by the conjugate and these fluoresced brightly; all others were entirely negative. FA tests were negative for 7 strains of R. meliloti, 9 strains of R. leguminosarum, 9 strains of R. trifolii, 6 strains of R. phaseoli, and 65 unidentified bacteria isolated from 12 soils. R. japonicum grew in autoclaved soil and was readily detectable by FA examination of contact slides. The FA technique also detected antibody-reacting bacteria in a field soil whose rhizobial content was unknown. Fluorescent cells were probably R. japonicum, since nodules developed on soybean plants grown in the same soil sample and FA preparations of the crushed nodules proved positive. Autofluorescence was not a problem, but nonspecific adsorption of conjugate restricted observations to microscopic fields free from soil particles. Nonspecific adsorption was substantial, irrespective of the soil used.


In vitro analyses of the binding of 131-I-iodide to milk protein.


Actinomycin analogues containing pipecolic acid: relationship of structure to biological activity. Streptomyces antibioticus synthesizes a mixture of actinomycins which differ at the "imino acid" site of the peptide chains. In the presence of exogenous pipecolic acid, several new actinomycins were synthesized and 70% of the proline in the antibiotic mixture was replaced by the analogue. Three new antibiotics (designated Pip 1alpha, Pip 1beta, and Pip 2) were isolated from culture filtrates, purified, and crystallized. The molar ratio of pipecolic acid to proline was: Pip 1alpha, 1:0; Pip 1beta, 1:1; Pip 2, 2:0. These compounds inhibited the growth and cell division of gram-positive, but not gram-negative, bacteria. The relative inhibitory activity against bacteria, Escherichia coli deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase in vitro, and RNA synthesis in Bacillus subtilis and mouse L-929 cells was: actinomycin IV = Pip 1beta > Pip 2 > Pip 1alpha. Protein synthesis in B. subtilis was less affected, and DNA synthesis was inhibited only at higher concentrations of antibiotic tested. In L cells, DNA formation was reduced less than RNA synthesis, whereas protein synthesis was not blocked under the experimental conditions employed. Kinetic studies with B. subtilis revealed that RNA synthesis was inhibited rapidly followed by an inhibition of protein synthesis. All four antibiotics markedly inhibited the replication of vaccinia virus and reovirus in tissue culture cells, but the production of poliovirus was resistant to the antibiotics. These actinomycins bind to DNA, resulting in an elevation of its T(m) and a decrease in the peak extinction of the actinomycins. The mode of action, as well as the structure-activity relationships among the actinomycins, are discussed relative to a previously proposed model of binding.


Gastrectomy.

Gastrectomy.


Increasing nursing skills and responsibilities in neurosurgical nursing.


Abnormalities of conduction and arrhythmias in the most common cardiopathies amongst the South African Bantu.


Studies on human peripheral lymphocytes: antibody and DNA synthesis and incorporation of 14C-labelled amino acids, following antigenic stimulus.


The disgnostic significance of fractionation of sera with paraproteins by gel filtration.


Comments on Dr. Tenzel's letter.

Comments on Dr. Tenzel's letter.


Studies on diabetic retinopathy. 3. Influence of diabetes on intramural pericytes.


Observations with the light microscope on the distribution and connexions of the oxytalan fibre of the lower jaw of the mouse.


The use of Wool Fast Blue BL for the electrophoresis of human parotid saliva proteins in acrylamide gel.


Immunoglobulin E, a new class of human immunoglobulin.


The significance of the cortex for the travelling phenomenon of brain waves.


Alpha blocking during visual after-images.


Topography of the human motor potential.


Disturbances of rapid eye movements during sleep in patients with lesions of the nervous system.


Cortical temperature during paradoxical sleep in the monkey.


Frequency-following (microphonic-like) neural responses evoked by sound.


Delayed termination of the muscle silent period in cerebellar disorders.


Cross-correlation of electromyograms showing interference patterns.


An investigation of auditory evoked responses of mentally retarded adults during sleep.


The effect of selected neuromuscular blocking agents and spinal cord transection on cortical after-discharge duration in the cat.


A neutral buoyancy micro-electrode for prolonged recording from single nerve units.


EMG findings in mild cases of myasthenia gravis during and after a short course of moderate doses of ACTH.


Symptomatic nocturnal myoclonic jerks.

Symptomatic nocturnal myoclonic jerks.


Interference of high frequency thalamic stimulation in conditioned "avoidance".


An electroencephalographic investigation in acute quinine poisoning.


Partial and generalized seizures induced by cobalt powder in the ventral amygdala of the cat.


Megimide and intracarotid amytal in epileptic subjects and the comparison of the convulsive threshold of the two cerebral hemispheres.


A statistical study of waking-sleeping and sleep stages in cats with chronic lesions of the thalamus.


Intracarotid Megimide in the study of the hemispheral convulsive threshold in man.


Preliminary observations on the power spectrum of the human EEG.


Conduction velocity in the sciatic nerve of man.


Modifications of nerve action potentials in relation to different parameters of stimulation.


The problem of epileptic psychosis: presentation of three cases.


Papez circuit and regulation of the hippocampal theta rhythm in the cat.


Micro-electrode recordings from the human thalamus. Some observations on the functional characteristics of somato-sensory neurons.


Neurophysiological and clinical observations in a case of epilepsia partialis continuans.


The recovery cycle of the visual evoked potentials in normal subjects and in patients with endogenous depression.


Clinico-polygraphic considerations on "slow sleep" idiopathic narcolepsy.


A statistical study of the amount of diffuse synchronous spike and wave activity during nocturnal polygraphic recording in epileptics.


Autonomic attacks and paroxysmal EEG features during development.


Motor conduction velocity in alcoholic patients.


Subcortical linkages between thalamic trigeminal relay nuclei.


Sleep EEG patterns during the apallic syndrome.


The sleep cycle in coma: prognostic value.


Intracellular study of synaptic activities in neurons of nucleus lenticularis.


Is the EEG of value in reanimation? The clinician's point of view.


The EEG of recent cranial trauma in a reanimation service.


Recent techniques of electrical reanimation of the heart and the EEG.


The EEG and reanimation in cardiac surgery.


Long term EEG and EMG studies after cardiac arrest.


Morphology and evolution of the EEG in acute cerebral anoxia (42 cases).


Significance of the EEG recorded during operations on the carotid.


Value of the EEG during reanimation of acutely decompensated patients with chronic pulmonary insufficiencies.


Prevention of post-anesthetic respiratory insufficiency by controlled narcosis.


The EEG in hyperbaric oxygen therapy.

The EEG in hyperbaric oxygen therapy.


EEG problems in a children's reanimation service.


Prognostic value of neurophysiological studies in the first hours following resuscitation: a review of 120 children after cardiac arrest.


The electroencephalogram during renal insufficiency.


Nocturnal sleep in chronic uremic patients undergoing extrarenal detoxication.


The epilepsy of renal insufficiency and incidental epileptic attacks during extrarenal detoxication.


Epileptic attacks provoked by injections of concentrated non-convulsant substances. I. The special case of insulin.


Epileptic attacks provoked by injections of concentrated non-convulsant substances. II. The case of ammonium salts.


EEG aspects of acute intermittent porphyria.


EEG evolution in a case of hepatic coma  complicated by acute hepatitis and successfully treated by repeated exchange transfusions.


Telemetric recordings in epileptic subjects while at work.


Evoked potentials in coma.

Evoked potentials in coma.


Value of EEG monitoring in reanimation of comas due to acute drug intoxication.


The EEG during acute intoxication with hypnotics.


Epilepsy with respiratory changes including prolonged apnea during severe digitalis intoxication.


Contraindications to smallpox vaccination.


Heterologous antilymphocyte globulin.

Heterologous antilymphocyte globulin.


Adaptation of response-recognition training film for use in the classroom.


Estimaion of the universality of Freudian and Jungian sexual symbols.


Signs of creativity on the Kahn test of symbol arrangement.


Ruthenium tetroxide for fixing and staining cytoplasmic membranes.


Interatrial conduction in the rat.

Interatrial conduction in the rat.


Quantitative determination of antibody-bound labeled antigens by filtration through cellulose porous membranes.


Reaction of proteins with glutaraldehyde.


Selective absence of IgA: a family study.


Undergraduate training in otolaryngology in the University of Newcastle upon Tyne.


The demonstration of antibodies to para-aminosalicylic acid in human serum.


Chromosomal changes of immunoglobulin-producing cell lines from human lymph nodes with and without lymphoma.


Pathogenesis of avian lymphoid leukosis. II. Immunologic reactivity during lymphomagenesis.


Plasma cell leukemia in BALB-c mice inoculated with subcellular material. II. Serological changes.


The clinical use of the superior vena cava-pulmonary artery shunt: a report of 20 cases.


The effect of reticuloendothelial blockade on antibody formation and immunologic tolerance.


Early immunoglobulin formation and hemagglutinating and bactericidal titers in Erythrocebus patas after oral adminstration of a weakly pathogenic Shigella strain.


Sex-linked factor influencing the catabolism of serum gammaG-globulins and transferrins in the mouse.


Phylogenetic studies of shark immunoglobulins.


Control of growth of axemic cultures of mammalian cells by serum lipids.


Delayed motor development.

Delayed motor development.


Developmental hyperactivity.

Developmental hyperactivity.


Developmental clumsiness.

Developmental clumsiness.


Delayed speech. Developmental mutism.

Delayed speech. Developmental mutism.


Developmental dyscalculia.

Developmental dyscalculia.


Developmental dyslexia.

Developmental dyslexia.


Cluttering. Central language imbalance.

Cluttering. Central language imbalance.


Dysacusis.

Dysacusis.


Right-left discrimination.

Right-left discrimination.


Developmental Gerstmann syndrome.

Developmental Gerstmann syndrome.


Syndromes of "minimal cerebral damage".

Syndromes of "minimal cerebral damage".


Extrathyroid effects of some antithyroid drugs and their metabolic consequences.


The long-acting thyroid stimulator: its role in Graves' disease.


Smog: Los Angeles running hard, standing still.


Clinical comparative experiment on 2 ointments of different extractive heparinoid concentrations (double blind test).


A case of Fahr's disease with an unusual perivascular pas-positive matrix in the molecular layer of the cerebellar cortex.


Studies on poliovirus inhibitors in sera of domestic animals. II. Determination of poliovirus inhibitors by the precipitation-in-agar-gel method.


A simple method for histochemical indentification of acid mucopolysaccharides in cryostat sections.


Homework for low vision patients.

Homework for low vision patients.


Studies on erythro-kinetics in infancy. 8. Mixing, disappearance rates and distribution volume of labelled erythrocytes and plasma proteins in early infancy.


Ultrastructural studies in alcoholic liver disease.


Our method for sorting out the mentally retarded children among the deaf.


Serological and physico-chemical characteristics of antibodies against Listeria monocytogenes in normal human sera.


Deamination to prevent the competitive effect of proteins in the metachromatic staining of sections at low pH-values.


Histochemical studies on the rat submaxillary gland during post-natal development.


Acetylation of histones by a kinase from rat liver nucle.


The role of ribosomal protein for the binding of dihydrostreptomycin to ribosomes.


Combined psychotherapy and deconditioning of a child's phobia.


Stimulus trace in the mentally retarded: defect or developmental lag?


Alternation of glycerokinase activity in rat liver in different nutritional and hormonal states.


Motility in Pseudomonas fluorescens with special reference to survival advantage and negative chemotaxis.


Effect of mestranol and chlormadinone acetate on urinary excretion of FSH and LH.


Binding of 125-I-labeled anti-L chain to polysomes of rat spleen in vitro.


Stoichiometry and site specificity of uncouplers of mitochondrial oxidative phosphorylation.


Lindane toxicity and protein-deficient diet.


Chloride efflux in cardiac Purkyno fibres and hydrogen ion concentration.


The thiocyanate oxygen equilibrium in "Helix pomatia" haemocyanin.


"In vitro" enzymatic formation of an auxin-like substance from L-tryptophan.


Capillary permeability to and extravascular dynamics of myoglobin, albumin and gammaglobulin in the uvea.


Limited enzymatic degradation of bacteriophage MS2 RNA.


[Alkaline and acid phosphomonoesterase and phosphodiesterase activities in chicken eggs. II].


Laevorotation between pH 5.1 and 8.8 of beta-lactoglobulin A and B with blocked thiol groups.


Enhancement of the dissociation in alkaline medium of beta-lactoglobulin B by blocking the thiol groups.


Potassium movements during electrical stimulation of the isolated rat aorta.


The phagocytic activity of the trabecularmeshwork endothelium. An electron-microscopic study of the vervet (Cercopithecus aethiops).


Palliation of breast cancer.

Palliation of breast cancer.


Effects of laser irradiation on some serologic properties of human gamma globulin.


Retention of urine due to simple prostatic enlargement: treatment by prostatic injection.


On the cilium cell relationship in the adenohypophysis of the mouse.


Studies on the organon vasculosum laminae terminalis. II. Comparative morphology of the organon vasculosum laminae terminalis of fishes, amphibia, reptilia, birds and mammals.


Plasma cell myeloma with D-myeloma protein (IgD myeloma).


The unusual association of myasthenia gravis and hypergammaglobulinemia.


Primary amyloidosis with "monoclonal" immunoglobulin A proteinemia.


Heart transplant: early postoperative care.


The diagnostic significance of serum electrophoresis in acute renal disease.


The OR nurse in the patient care circuit.


Determination of serum IgM levels for the diagnosis of T. rhodesiense infection. A study of 45 cases.


Psychological testing: its usefulness in teaching psychotherapy and psychodynamics to medical students.


The production of fluorescent antibody reagents for virus diagnosis in the albino mouse. I. Hyperimmune anti-species serum.


Variations in the carbohydrate content of rabbit gamma-G-globulin.


Studies of plasma protein synthesis by peripheral cells from normal persons and patients with infectious mononucleosis.


Diagnostic and prognostic values of measurement of serum vitamin B12-binding proteins.


Serum protein alterations in adjuvant-induced arthritis.


Transient distributions ensuing when ultracentrifugal equilibrium is disturbed by a substantial increase in speed.


Aggregation of an immunoglobulin fragment by sulfhydryl oxidation.


Cryogenic technics in stereotaxic neurosurgery. Cryohypophysectomy and cryothalamectomy.


Cooperative studies of sequens, a sequential oral contraceptive agent, in Japan.


Controlled trial of soya-bean oil in myocardial infarction.


Influence of gastric emptying-rate and of insulin response on oral glucose tolerance in thyroid disease.


Insulin-stimulated lipogenesis in arterial tissue in relation to diabetes and atheroma.


Acute renal failure in the cold-agglutination syndrome.


Decrease of total serum-bilirubin concentration in newborn infants after phenobarbitone treatment.


Tachycardia and the neuropathy of porphyria.


Retention of cyanocobalamin, hydroxocobalamin, and coenzyme B12 after parenteral administration.


Fatal hypoglycaemia in rats following total pancreatectomy combined with partial hepatectomy.


The infective process in scrapie.

The infective process in scrapie.


Phenacetin.

Phenacetin.


Persistence of treponemes after treatment of syphilis.


International classification of breast tumours.


Preparation for paediatrics.

Preparation for paediatrics.


Electronic editors.

Electronic editors.


Another respiratory-virus vaccine.

Another respiratory-virus vaccine.


Late effects of torture.

Late effects of torture.


Pay-off, heuristics, and pattern recognition in the diagnostic process.


Teaching and research in a district general hospital.


Cross-circulation between man and baboon in hepatic coma.


Sequels of unwanted pregnancy.

Sequels of unwanted pregnancy.


Renal function in nephritis.

Renal function in nephritis.


Complications of methohexitone.

Complications of methohexitone.


Hypertension in pyelonephritis.

Hypertension in pyelonephritis.


Changes of oxygen affinity of blood at low and high pressures.


Cancer in children.

Cancer in children.


Immunoglobulins in De Lange syndrome.

Immunoglobulins in De Lange syndrome.


Urinary magnesium and renal stones.

Urinary magnesium and renal stones.


Serum-gonadotrophins after oxytocin in man.


Haemolytic-uraemic syndrome.

Haemolytic-uraemic syndrome.


Phenylbutazone for prolapsed discs?

Phenylbutazone for prolapsed discs?


Atraumatic endotracheal-tube valve.

Atraumatic endotracheal-tube valve.


Toxicity of a trimer of malononitrile.

Toxicity of a trimer of malononitrile.


Urinary acid mucopolysaccharides in Morquio's disease.


Arnold Learoyd Walker.

Arnold Learoyd Walker.


Henry Albert Harris.

Henry Albert Harris.


IgA deficiency: family studies.

IgA deficiency: family studies.


Effect of lymphocyte stimulants on specific antibody synthesis in vitro.


Collagenase digestion for distinguishing neural from reticular fibres in silver stains.


Staining pericellular boutons of glutaraldehyde-fixed nervous tissue; a chromation-silvering sequence for frozen sections.


Supravital staining of mammalian brain with intra-arterial methylene blue followed by pressurized oxygen.


Acid orcein-iron and acid orcein-copper stains for elastin.


Absorption and fluorescence spectra of euchrysine GGNX and acridine orange; effects of heparin, NaCl and a cation exchange resin.


A modified one-step trichrome stain for demonstration of fine connective tissue fibers.


The use of haematoxylin for squash preparations of chromosomes.


Diazo methylene violet as a protein reagent.


Human operator response speed, frequency, and flexibility: a review, analysis and device demonstration. NASA Contract Rep NASA CR-874.


Comparison of a T4 resin sponge uptake method with a protein-bound iodine procedure.


Technics for the analysis of biliary calculi.


Sickle cell disease and viral hepatitis.


Nephropathy induced by D-penicillamine.

Nephropathy induced by D-penicillamine.


Treatment of thyrotoxicosis.

Treatment of thyrotoxicosis.


Selective chemical sympathectomy.

Selective chemical sympathectomy.


Drugs for tuberculosis.

Drugs for tuberculosis.


Inhibition of RNA polymerase of Escherichia coli by an antimicrobial substance B44P (streptovaricin).


Antigen-indued histamine release from peritoneal mast cells of mice producing reagin-like antibody.


Glycogen contents of primate hair follicles.


Surface coats containing polysaccharides on human epidermal cells.


Intercellular adhesion and surface coats of epidermal cells in psoriasis.


Comparative analysis of the IgG heavy chain carbohydrate peptide.


Estimation of fetal maturity by amniotic fluid exfoliative cytology,.


Cross-circulation between man and baboon.


Acute hepatic coma treated by cross-circulation with a baboon and by repeated exchange transfusions.


Symptoms and survival in lung cancer.

Symptoms and survival in lung cancer.


Cephaloridine compared with penicillin and streptomycin in exacerbations of chronic mucopurulent bronchitis. Report to the Research Committee of the  British Tuberculosis Association.


A comparative study of ampicillin, tetracycline hydrochloride, and methacycline hydrochloride in acute exacerbations of chronic bronchitis.


Caeruloplasmin and green plasma in women taking oral contraceptives, in pregnant women, and in patients with rheumatoid arthritis.


Calorie requirements of children recovering from protein-calorie manutrition.


Ascorbic-acid levels in leucocytes of patients with gastrointestinal haemorrhage.


Abnormalities in urinary gonadotrophin excretion in men with a 47,XYV sex chromosome constitution.


Measles as an index of immunological function.


Hypertension in pyelonephritis.

Hypertension in pyelonephritis.


Vaccination against measles.

Vaccination against measles.


Aspirin intolerance.

Aspirin intolerance.


Cancer in cats and dogs.

Cancer in cats and dogs.


Factors in population growth.

Factors in population growth.


Hospital infection from contaminated ice.


Genetics of anencephaly and spina bifida?


A classification of chronic hepatitis.

A classification of chronic hepatitis.


The family of the fatally burned child.

The family of the fatally burned child.


Bagdade JD: Basal insulin and obesity.

Bagdade JD: Basal insulin and obesity.


Sequels of unwanted pregnancy.

Sequels of unwanted pregnancy.


X-rays and childhood cancer.

X-rays and childhood cancer.


Renal function in nephritis.

Renal function in nephritis.


Implants and the human body.

Implants and the human body.


Familial XY gonadal dysgenesis.

Familial XY gonadal dysgenesis.


YY syndrome in a Mexican.

YY syndrome in a Mexican.


Deficient argininosuccinase activity in brain in argininosuccinicaciduria.


Urinary magnesium and renal stones.

Urinary magnesium and renal stones.


Urinary rhythm after renal transplantation.


The vulnerable oesophagus.

The vulnerable oesophagus.


Management of cervical carcinoma-in-situ.


Improved skin-marking.

Improved skin-marking.


Diabetes mellitus and pernicious anaemia.


Treating neonatal vasospasm.

Treating neonatal vasospasm.


Intestinal absorption of peptides.

Intestinal absorption of peptides.


Aviator's cancer.

Aviator's cancer.


Educating deaf children.

Educating deaf children.


Predicting serum-calcium after haemodialysis.


Anti-tumour effect of activated lymphocytes.


Fracture of the distal radius including sequelae--shoulder-hand-finger syndrome, disturbance in the distal radio-ulnar joint and impairment of nerve function. A clinical and experimental study.


Endocrine investigations in De Lange's and Seckel's syndromes.


Audiovisual education: yesterday, today, and tomorrow.


Evaluation of audiovisual methods of medical teaching.


Immunochemical and morphologic comparison of donor tissues with immunoglobulin-producing tissue culture lines from two patients with malignancies.


Adapting the dental operatory for visual education.


Hyperviscosity syndromes.

Hyperviscosity syndromes.


Differential release of histamine by 5-hydroxy-tryptamine, noradrenaline and reserpine from neoplastic mast cells in vitro: biological and fluorescence microscope observations.


The aged thyroid gland.

The aged thyroid gland.


Clinical enzymology and diseases of the lungs. A critical reappraisal.


The effects of Clostridium histolyticum collagenase on amino sugar-containing compound-collagen complexes.


Antigens, RNAs, and macrophages.

Antigens, RNAs, and macrophages.


Temporary inhibition of antibody production by 6-mercaptopurine.


Some cytochemical properties of the lumbosacral neuronal inclusions of the pigeon.


A new audiovisual aid to heart-sound instruction.


Fluorescence staining of glycerinated myofibrils with 1-anilino naphthalene-8-sulfonate.


Antibiotic toxicity in white mice.

Antibiotic toxicity in white mice.


The jelly baby. Conception, immaculate and non-immaculate.


An evaluation of hypnagogic hallucinations.


An electrophoretic study of serum glycoproteins in clinical Johne's disease of cattle.


The immunoelectrophoretic patterns of some body fluids of sheep.


Turnover of 57Co-labelled vitamin B12-transcobalamin II and autologous 131-I-labelled IgG in a patient with antibody to transcobalamin II.


An improved method of processing bone marrow for chromosomes.


A new type of inclusion bodies in lymphocytes.


Immunoglobulin changes in the course of infectious mononucleosis.


Comparative aspects of primary structures of proteins.


Effect of iodide on recovery of function of rat thyroid gland after administration of antithyroid agents.


Endocrine role of follicles in the regulation of corpus luteum function in the rabbit.


Stimulation by insulin and prostaglandin E1 of glucose metabolism and inhibition of lipolytic action of theophylline on fat cells in the absence of K+.


Comparative studies on rabbit gamma-G and gamma M haemolytic anti- bodies.


Isolation and properties of a low molecular weight beta-2-globulin occurring in human biological fluids.


Ontogeny of the immune response. V. Further characterization of 19S gamma-G- and 7S gamma-G-immunoglobulins in the true primary immune response in germfree, colostrum-deprived piglets.


Banding of the pulmonary artery: a palliative surgical procedure.


Treatment of homocystinuria with a low-methionine diet, supplemental cystine, and a methyl donor.


Leprosy. IV. The quantitation of immune globulins (IgG, IgA, and IgM) in leprosy sera.


Leukocyte bound gamma-globulin in patients with Stevens-Johnson syndrome.


A case of familial intrahepatic cholestasis.


Inhibitory effects of monoclonal immunoglobulins on anti-globulin reaction.


The change in the shape of peritoneal macrophages after stimulation, as studied by the tragacanth-PAS technique.


Electron-cytochemical localization of acid phosphatase activity in the digestive caeca of the desert locust.


The effect of polyene macrolides on the prostate gland and canine prostatic hyperplasia.


The requirement for sensitized lymphocytes in one form of antigen-induced histamine release from rabbit platelets.


Aspiration lung biopsy. A useful radiologic supplement.


Localization of immunoglobulins in the developing chicken bursa of Fabricius.


Fibrous xanthomas of the conjunctiva.

Fibrous xanthomas of the conjunctiva.


On the structure of the leukemia viruses.


The influence of lysozyme on the appearance of epiphyseal cartilage in organ culture.


Guinea pig adipose tissue responsiveness to catecholamines.


In vivo and in vitro effect of sulfathiazole on serum glycoproteins.


A note on the mechanism of the Marchi reaction in degenerating myelin.


Incidence and distribution of various connective tissue fibers in oral fibromas.


Congenital epulis (congenital granular-cell myoblastoma). Report of two cases.


Microscopic and microrespirometer (QO2) study of the effect of cigarette smoking on human oral soft tissues. Preliminary report of an in vivo study.


Neuronal geometry: determination with a technique of intracellular dye injection. In a study of the specificity of neuronal connections in lobster abdominal ganglia, the dye Procion Yellow M4RS was electrophoretically injected into identified cell bodies. This dye spreads into fine branches of cells, survives fixation and routine histological procedures, and permits the reconstruction of cell shapes through examination of serial sections of ganglia. Certain cells were found to have an internal bilateral symmetry. Repeated injection of the same cells in ganglia from different animals showed that cells have characteristic shapes and that the neuropil is highly structured. This method of dye injection should have general applicability in studies where a knowledge of the geometry of specific cells is important.


That polluting automobile.

That polluting automobile.


Computer-assisted instruction.

Computer-assisted instruction.


Therapeutic problems of ulcerative colitis with hyperthyroidism.


Acute hyaline necrosis of the liver. A surgical trap.


A philosophy of treatment of esophageal carcinoma.


Electron-microscopic observations on whole human mitotic chromosomes.


Further electron microscope studies on fibrillar organization of the ground cytoplasm of Chaos chaos. Further evidence for fibrillar organization of the ground cytoplasm of Chaos chaos is presented. Fixations with osmium tetroxide at pH 6 or 8 and with glutaraldehyde at pH 6 or 7 were used on two preparations: (a) single actively streaming cells; (b) prechilled cells treated with 0.05% Alcian blue in the cold and returned to room temperature for 5-10 min. In addition, a 50,000 g pellet of homogenized cells was examined after fixation with glutaraldehyde-formaldehyde alone. In sections from actively streaming cells considerable numbers of filaments were observed in the uroid regions after glutaraldehyde fixation, whereas only traces of filaments were seen after osmium tetroxide fixation at either pH 6 or 8. Microtubules were not seen. In sections from dye-treated cells, filaments (4-6 mmicro) and fibrils (12-15 mmicro) were found with all three fixatives. The 50,000 g pellet was heterogeneous but contained both clumps of fibrils and single thick fibrils like those seen in the cytoplasm of dye-treated cells. Many fibrils of the same dimensions (12-15 mmicro wide, 0.5 micro long) were also seen in the supernatant above the pellet. Negative staining showed that some fibrils separated into at least three strands of 4-6 mmicro filaments.


The relationship of breast cancer to thyroid disease.


Testosterone-binding globulins in human plasma: studies on sex distribution and specificity. When human plasma is mixed with testosterone-(3)H and subjected to electrophoresis on paper in glycine acetate buffer at pH 8.6, at least two proteins other than albumin bind the testosterone. In normal women 80.5 +/- 1.9% (SEM) of the recovered radioactivity migrates with the beta-globulins, 7.3 +/- 0.80% with the inter-alpha-globulins, and 4.3 +/- 0.40% with albumin. In normal men the percentages are 69.3 +/- 3.0%, 14.3 +/- 1.6%, and 6.2 +/- 1.1%, respectively. These differences between men and women in binding among the beta-globulins and inter-alpha-globulins are statistically significant (P < 0.001). The highest percentages of radioactivity associated with the beta-globulins are seen in infants of both sexes, men receiving diethylstillbestrol, and pregnant women. These same subjects have the lowest percentages of radioactivity associated with the inter-alpha-globulins. Experiments with carrier testosterone indicate that at least some of the differences between the normal men and women and infants can be explained by differences in the concentration of endogenous testosterone. This factor alone, however, cannot explain the increased binding among the beta-globulins in the men receiving diethylstilbestrol or in the pregnant females. In this system estrone, estradiol, dehydroisoandrosterone, androsterone, 17alpha-hydroxyprogesterone, and 19-nortestosterone compete with testosterone for binding sites on the proteins. None is as potent as testosterone itself.


Studies of peripheral thyroxine distribution in thyrotoxicosis and hypothyroidism. Compartmental analysis of the peripheral distribution of labeled thyroxine was applied to various groups of subjects with thyrotoxicosis and hypothyroidism. It was observed that the hepatic incorporation of thyroxine was augmented in subjects with Graves' disease when compared to non-Graves' disease control groups at all levels of thyroid function. Decreased values of hepatic incorporation occurred in primary hypothyroid subjects. These lowered values were not acutely corrected by elevation of the serum thyroxine level, but were observed to be rectified after several months' therapy with exogenous thyroid hormone. These alterations of the hepatic thyroxine-(131)I incorporation were independently verified by direct quantitative liver scintiscan determinations. Employing a dual thyroxine tracer system, we were able to demonstrate that during the early phases of equilibration of a tracer dose of thyroxine, alterations in the rate of deiodination were observed to be present in the various thyroid disease states. Increased deiodination rates were found in subjects with Graves' disease and the reverse was noted in patients with primary hypothyroidism. Kinetic analysis of thyroxine compartmental distribution during this early phase of equilibration of a labeled thyroxine tracer indicated that the primary tissue uptake occurred in the liver. These findings supported the contention that the amount of labeled thyroxine incorporated in the liver may be directly related to the deiodination rate of thyroxine by that organ. The pathogenetic basis of these alterations is presently unknown.


Isolation and characterization of permeability factors from rabbit neutrophils. Four basic proteins that increase vascular permeability have been isolated in purified form from rabbit neutrophilic granules. These proteins are termed band 1, 2, 3, and 4 protein according to their electrophoretic migration in acrylamide gel. Molecular weights of band 1 and 2 protein derived from amino acid composition were 4800 and 5300, respectively. These values are in good agreement with those obtained for these proteins by gel diffusion techniques. The molecular weight of band 3 protein was also in the range of 5000 by the latter technique. The molecular weight of band 4 protein determined by ultracentrifugal analysis and amino acid composition was 12,000. Although all four proteins had the capacity to induce immediate increase in vascular permeability, only band 2 protein was found to release histamine from isolated rat peritoneal mast cells. Furthermore, it has been shown that the permeability-inducing activity of band 2 protein can be inhibited by pretreating rabbits with antihistamine. Band 2 protein did not release histamine from rabbit platelets and depletion of rabbit platelets from the circulation had no influence on the permeability-inducing activity of this protein. Band 1, 3, and 4 proteins did not release histamine from isolated rat peritoneal mast cells and their capacity to increase vascular permeability remained unaffected by treatment of rabbits with antihistamine. These investigations suggest that the histamine-releasing activity of band 2 protein is a specific phenomenon and is associated with particular amino acid grouping or spacial configuration of the molecules. By the same token, the increase in vascular permeability induced by the nonhistamine-releasing band 1, 3, and 4 proteins represents a specific phenomenon (or phenomena) not particularly related to the over-all charge of these molecules.


Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to Fc fragment. The opsonic properties of immune gammaG-globulins isolated from patients with chronic septicemic conditions, principally subacute bacterial endocarditis were studied. Opsonic capacity as well as complement-fixing properties of gamma-globulins appeared to be closely associated with integrity of Fc structures. Progressive pepsin digestion of immune gammaG-globulins, as monitored by successive loss of Gm(a) and Gm(b) antigens, abolished opsonic activity. Colostral gammaA, containing agglutinating antibacterial antibodies but no demonstrable complement-fixing activity, was devoid of opsonic capacity. Reduction of gamma-globulin opsonins with 0.01 or 0.1 M mercaptoethanol progressively abolished opsonic activity in parallel with loss of ability of treated gamma-globulins to fix complement with bacteria. Treatment of gamma-globulin opsonins with 0.01 M sodium metaperiodate also produced complete loss of opsonic capacity in parallel with loss of Gm(b) Fc antigens. These findings, together with antiopsonic effects demonstrable with anti-gamma-globulin factors showing primary reactivity with Fc structures, indicate that the opsonic property of immune gamma-globulins requires the participation of structures integral to the Fc region of gamma-globulin.


Lateral giant fibers of cray fish: location of somata by dye injection. Using a new technique for injecting fluorescent dye, we have analyzed the intraganglionic architectutre of the lateral giant interneuron in crayfish. Each lateral giant interneuron comprises a giant axon, an ipsilateral dendritic arborization of fairly constant form, and a contralateral soma. Antidromic axon spikes produce only, small, electronic potentials in the soma; direct depolarization there fails to produce electrically excitable membrane responses and cannot discharge the main axon.


As I see it: O.R. education.

As I see it: O.R. education.


Reflextions on heart transplantation.

Reflextions on heart transplantation.


First heart transplant.

First heart transplant.


The disappearing operating room nurse.

The disappearing operating room nurse.


Member in the spotlight (Jerry Peers).

Member in the spotlight (Jerry Peers).


Whose loss?

Whose loss?


As I see it: O. R. education.

As I see it: O. R. education.


Directory of AORN chapters by state and city.


Current practice committee proves effective.


A student's viewpoint.

A student's viewpoint.


Editorial: what are we doing to assist and encourage the OR nurse?


Lung cancer: implications for nursing care.


The New Zealand surgical team in Vietnam 1966-67.


Royal Perth Hospital, Australia; theatre management course.


Iron--the missing element.

Iron--the missing element.


Visual aids to teaching midwifery.

Visual aids to teaching midwifery.


High-risk surgery: nursing the patient with hepatic lobectomy.


Forming concepts.

Forming concepts.


The handicapped child: emotional needs.

The handicapped child: emotional needs.


Actinomycin monolactone, an intermediate in the biosynthesis of actinomycin.


Immunological studies of proteins associated with the subcellular fractions of thrombasthenic and afibrinogenaemic platelets.


Catabolism of native and denatured serum 131-I-proteins by polymorphonuclear leucocytes.


Effects of histones and polylysine on the synthetic activity of the giant chromosomes of salivary glands of dipteran larvae.


Aetiology of regional enteritis.

Aetiology of regional enteritis.


Ventricular fibrillation complicating acute myocardial infarction.


Mechanism of folate deficiency in patients receiving phenytoin.


Impairment of intestinal deconjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy.


Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid.


Iron-binding properties of gastric juice in idiopathic haemochromatosis.


Thymic and parathyroid origin of calcitonin in man.


Glucose intolerance in newborn infants undergoing surgery for alimentary-tract anomalies.


Psychic reactions after analgesia with nitrous oxide for caesarean section.


Arvin treatment for sickle-cell crisis.

Arvin treatment for sickle-cell crisis.


Erythrocyte-transketolase activity in megaloblastic anaemia.


Hazards of cardiac catheterisation.

Hazards of cardiac catheterisation.


Management of cervical carcinoma-in-situ.


Treatment of chronic hepatitis.

Treatment of chronic hepatitis.


Disintegration at Lord's.

Disintegration at Lord's.


Dissappearing blood.

Dissappearing blood.


Social work in general practice.

Social work in general practice.


The Blackburn poliomyelitis epidemic. An analysis of the 109 cases admitted to hospital.


Hospital caseloads in Liverpool, New England, and Uppsala. An international comparison.


Commonwealth medical immigrants.

Commonwealth medical immigrants.


An attack of tetanus.

An attack of tetanus.


Malaria and the population explosion.

Malaria and the population explosion.


Hospital-based family planning.

Hospital-based family planning.


[Oestrogens, progesterone, and platelets].


Progesterone level and response to oxytocin at term.


Prader-Willi syndrome.

Prader-Willi syndrome.


Erythroid-cell enzyme activity in chronic renal failure.


The vulnerable oesophagus.

The vulnerable oesophagus.


Synovectomy for haemophilic haemarthrosis.


Two forms of haemophilia.

Two forms of haemophilia.


Death during therapeutic starvation.

Death during therapeutic starvation.


Autoimmune diseases in Nigerians.

Autoimmune diseases in Nigerians.


Radiation dose in isotope encephalography.


Splenomegaly and sickle-cell trait.

Splenomegaly and sickle-cell trait.


Annular pancreas in Down's syndrome.

Annular pancreas in Down's syndrome.


Sex-chromatin-negative women and epilepsy.


XYY chromosomal constituion in criminal psychopaths.


Histochemical diagnosis of biliary atresia.


Oral penicillins in chronic osteomyelitis.


Urinary magnesium and renal stones.

Urinary magnesium and renal stones.


Fiddler's Horner's syndrome.

Fiddler's Horner's syndrome.


Charles Arthur Lovatt Evans.

Charles Arthur Lovatt Evans.


Robert Daniel Lawrence.

Robert Daniel Lawrence.


Ronald Melville Norman.

Ronald Melville Norman.


A system for machine identification of bacteria.


Assessment of compositional relatedness between proteins.


Effect of internally injected radioisotopes on the connective tissue in the Indian catfish, Heteropneustes fossilis Bloch.


Rapid staining and identification of mycobacteria by fluorescence microscopy using uranine.


Immunoelectrophoretic study on the antigen composition of a mouse sarcoma.


Some immunological factors in small intestine disease. A review.


Rhinitis medicamentosa.

Rhinitis medicamentosa.


Experimental studies on the autotransplantation of thyroid gland using micro-vascular anastomoses.


Five years' experience in renal transplantation with immunosuppressive drugs: survival, function, complications, and the role of lymphocyte depletion by thoracic duct fistula.


Atrial septotome for palliative septectomy in infants with transposition of the great vessels.


Immunosuppression by cyclophosphamide in NZB X NZW mice with lupus nephritis.


Delayed pressure urticaria.

Delayed pressure urticaria.


A method for demonstration of sweat gland activity.


Dermatological manifestations of the immunity deficiency syndromes.


Immunoglobulin class E--anaphylactic antibodies.


Dissociation of histamine release and 22Na uptake in rat mast cells exposed to compound 48/80 in vitro.


Kinins and anti-inflammatory steroids.

Kinins and anti-inflammatory steroids. 1. This investigation was designed to re-examine the possibility that anti-inflammatory steroids interfere with the kinin-forming system.2. We conclude that the anti-inflammatory action of corticosteroids cannot be explained by the inhibition of kinin formation. This view is based on the following findings.3. Neither hydrocortisone nor prednisolone nor dexamethasone inhibited the activation or activity of intrinsic plasma kinin forming enzymes resulting from dilution, incubation with kininase inhibitors, or exposure to glass, monosodium urate microcrystals or to precipitated complexes of rheumatoid factor and aggregated human gamma-globulin.4. Hydrocortisone did not inhibit the action of the active kinin-forming enzymes, human salivary or urinary kallikrein, or plasmin on purified kininogen.5. Hydrocortisone, prednisolone and dexamethasone did not inhibit the hydrolysis of benzoyl-arginine-ethyl ester by human plasmin, plasma kallikrein or hog pancreatic kallikrein.6. Kinin formation occurred normally in plasma taken from two patients receiving betamethasone and one receiving prednisone.


Site of ionic binding of sodium and histamine in mast cell granules.


Influence of anti-rheumatic agents on histmine release from actively and passively sensitized rat peritoneal mast cells.


Histamine release from lung tissue of rat induced by bee venom fractions and compound 48-80.


Rhinitis and polyps.

Rhinitis and polyps.


Rotator cuff tendinitis.

Rotator cuff tendinitis.


Panhypoplasia of the bone marrow. I. Demonstration of a plasma factor with anti-erythropoietin-like activity.


Positive direct Coombs' test without hemolytic anemia, attributed to penicillin therapy.


Needed: a library for audiovisuals.

Needed: a library for audiovisuals.


Heart transplants in Canada.

Heart transplants in Canada.


Cutaneous hypersensitivity to deoxyribonucleic acid (DNA) in patients with ulcerative colitis.


Studies of testosterone binding globulin.


Observations against a causal relationship between the long-acting thyroid stimulator and ophthalmopathy in Graves' disease.


Analysis of prefission morphogenesis in Paramecium aurelia.


The C'la fixation and transfer test: examples of its applicability to the detection and enumeration of antigens and antibodies at cell surfaces.


Studies of human C-reactive protein in an in vitro phagocytic system.


Studies on human peripheral blood lymphocytes in vitro. V. Biosynthesis of immunoglobulins.


Studies on the ontogeny of the mouse immune system. II. Immunoglobulin-producing cells.


Neutralization and sensitization of herpes simplex virus with antibody fragments from rabbits of different allotypes.


Relationship of germinal centers in lymphoid tissue to immunologic memory. 3. Proliferative response of primed cells from splenic white and red pulp following reexposure to antigen in vitro.


Formation and transfer of antibodies in congenital murine infections with a type 2 reovirus.


Detection of gamma A antibody-releasing cells to erythrocyte and lipopolysaccharide antigens.


Rabbit blocking and binding antibodies to human intrinsic factor and intrinsic factor-B12 complex.


Antibody production stimulated in vitro in Burkitt lymphoma cells.


The association of the c7 allotype of rabbits with some light polypeptide chains which lack b locus allotypy.


Prognostic value of intraoperative blood-flow measurements in femoropopliteal bypass vein-grafts.


Heart-block following acute myocardial infarction. Treatment with demand and fixed-rate pacemakers.


Methohexitone relaxation for desensitising agoraphobic patients.


Some complications of using methohexitone to relax anxious patients.


Disodium cromoglycate in the treatment of bronchial asthma.


Chronic respiratory disease in a rural community.


Absence of coagulation abnormalities in children with cyanotic congenital heart-disease.


The hydrocortisone test in primary and tertiary hyperparathyroidism.


Sphingolopids and phospholipids of myelin in multiple sclerosis.


Flow-rates through disposable intravenous cannulae.


Disinfection of lung ventilators by alcohol aerosol.


Alcohol and the liver.

Alcohol and the liver.


Influenza.

Influenza.


Patient or donor?

Patient or donor?


Progress in nottingham.

Progress in nottingham.


Talking about addiction.

Talking about addiction.


N.H.S. medical staff in Scotland.

N.H.S. medical staff in Scotland.


Ethical and social aspects of treatment of spina bifida.


Reactions to penicillins.

Reactions to penicillins.


Children's hospitals, children's departments, and hospital child-health community centres.


Exercise-induced asthma.

Exercise-induced asthma.


Organ transplantation.

Organ transplantation.


Sequels of unwanted pregnancy.

Sequels of unwanted pregnancy.


L.E. cells after oral contraceptives.

L.E. cells after oral contraceptives.


Uptake of 65Zn in fractured bones.

Uptake of 65Zn in fractured bones.


Death during therapeutic starvation.

Death during therapeutic starvation.


Foetal cells in antepartum haemorrhage.

Foetal cells in antepartum haemorrhage.


A new human trisomy?

A new human trisomy?


Failure of suppression of arginine-induced growth-hormone response by dexamethasone.


Feedback control of male gonadotrophin secretion.


Arvin treatment for sickle-cell crisis.

Arvin treatment for sickle-cell crisis.


Management of cervical carcinoma-in-situ.


Serum-lipids in bushmen.

Serum-lipids in bushmen.


Increased anti-leukaemia activity of E. coli asparaginase in mice infected with L.D.H.-elevating virus.


Composition of vacuoles in P.H.A.-simulated blasts.


Propionate and acetate excretion in chloramphenicol toxicity.


Quadrilateral periarticular humping in indicidual digits.


Measurement of splenic haematocrit.

Measurement of splenic haematocrit.


A new polydactyly/imperforate-anus/vertebral-anomalies syndrome?


Blood-glucose levels after caffeine.

Blood-glucose levels after caffeine.


Cytomegalovirus infection with raised alkaline phosphatase.


Robert Eric Barnsley.

Robert Eric Barnsley.


The prophylaxis of Rh hemolytic disease with Rh immunoglobulin.


Diffuse (nonmyelomatous) plasmacytosis with dysproteinemia.


Detection of early myocardial infarction by the acid fuchsin staining technic.


Thyroid function evaluation in patients with increased or decreades thyroxine-bindling protein.


A new semiautomated method for the concentration of cerebrospinal fluid for cytologic examination.


Perilimbal amyloid tumor.

Perilimbal amyloid tumor.


Outbreak of viral hepatitis in a municipal hospital.


Staining of bilirubin and biliverdin in tissue.


Immunological unresponsiveness of guinea pigs to major antigens in heterologous whole serum.


Vectorcardiographic observations of postextrasystolic T wave changes associated with interpolated ventricular beats.


Catabolism of human gammaG-immunoglobulins of different heavy chain subclasses. I. Catabolism of gammaG-myeloma proteins in man. The rates of catabolism of human gammaG-immunoglobulins of subclasses gammaG(1), gammaG(2), gammaG(3), and gammaG(4) were studied by determining the rates of elimination from the circulation of pairs of (131)I-and (125)I-labeled gammaG-myeloma proteins in 57 patients suffering from cancer other than multiple myeloma. On the average, gammaG(1)-, gammaG(2)-, and gammaG(4)-myeloma proteins were catabolized at a rate similar to that of normal gammaG-immunoglobulin, whereas gammaG(3)-myeloma proteins were catabolized more rapidly than normal gammaG-immunoglobulin. The average half-lives for the myeloma proteins were 12.3 days for normal gammaG, 11.6 days for gammaG(1), 12.4 days for gammaG(2), 8.2 days for gammaG(3), and 11.3 days for gammaG(4). However, significant differences in catabolic rates were observed when individual myeloma proteins of a single subclass were compared. These individual variations were present within all four heavy chain subclasses. The extent of differences ranged from 10 to 47%. The catabolic rate of normal gammaG was in an intermediate range when compared with myeloma proteins of relatively long and short half-lives. The rate of catabolism of an individual myeloma protein did not correlate with its light chain type, Gm factor, carbohydrate content, or electrophoretic mobility. These findings indicate that the structure(s) related to the catabolism of gammaG-immunoglobulins are complex and differ from one immunoglobulin molecule to another.


National resources for continuing medical education.


Computer-based and computer-planned continuing medical education for the future.


Infectious mononucleosis: immunoglobulin synthesis by cell lines. Immunoglobulin synthesis by 16 long-term suspension cultures of mononuclear cells derived from peripheral blood of nine patients with heterophile-positive infectious mononucleosis (IM) has been demonstrated by radioimmunoelectrophoretic techniques. All cell lines synthesized molecules with IgG (gamma) heavy chain specificity. 14 cell lines produced molecules with IgM (mu) heavy chain specificity and 11 cell lines produced molecules with IgA (alpha) heavy chain specificity. No detectable synthesis of molecules with IgD (delta) heavy chain specificity was observed by these cell lines derived from peripheral blood of patients with IM. 13 cell lines produced molecules with type K (kappa) light chain specificity and 6 cell lines produced molecules with type L (lambda) light chain specificity. Of interest, 9 of 16 lines produced IgG (gamma), IgA (alpha), and IgM (mu) heavy chain molecules and 5 of these cell lines produced molecules with type K (kappa) and type L (lambda) light chain specificity as well. Further characterization by combined polyacrylamide gel filtration, immunodiffusion, and radioautography indicated the presence of newly synthesized immunoglobulin molecules with both heavy and light polypeptide chains in close association as well as free light polypeptide chain synthesis. Investigation of the localization of immunoglobulin in single cells by immunofluorescent techniques revealed that 5-22% of cells in these lines were strongly reactive with a fluorescein isothiocyanate-conjugated rabbit antisera directed against the antigenic determinants of human IgG and cross-reactive with the determinants common to IgA and IgM. No heterophile antibody, heteroagglutinin, or hemolytic antibody could be demonstrated in these cell lines derived from peripheral blood of patients with heterophile-positive infectious mononucleosis.


Growing clinical significance of methcillin-resistant Staphylococcus aureus.


Epidemiological and clinical picture of Addison's disease.


Symptoms of carcinoma of the colon and rectum.


Immediate renal-graft biopsy and subsequent rejection.


Endomyocardial fibrosis in a North American Negro. Probable familial incidence.


Effect of a pyrimido-pyrimidine compound on platelet behaviour in vitro and in vivo.


Value of fluid deprivation in large-dose urography.


Diffusion anoxia at birth.

Diffusion anoxia at birth.


Serum-insulin response to glucose and aminoacids in the premature infant.


Methicillin-resistant staphylococci.

Methicillin-resistant staphylococci.


Financing of health services in the U.S.A.


Hodgkin's disease: a search for a definition.


Sociological research.

Sociological research.


Biological views of race.

Biological views of race.


A broad look at the lymphomas.

A broad look at the lymphomas.


Biology and ethics.

Biology and ethics.


Yet another examination?

Yet another examination?


To impart the precepts and the instruction.


Biological causes and effects of paralytic shellfish poisoning.


Social work in general practice.

Social work in general practice.


Folic acid absorption in man.

Folic acid absorption in man.


Health and social services.

Health and social services.


An epidemic of mussel poisoning in North-East England.


Another hazard of percutaneous renal biopsy.


An effective antiherpetic drug?

An effective antiherpetic drug?


Disposable surgical gloves.

Disposable surgical gloves.


Hypertension in pyelonephritis.

Hypertension in pyelonephritis.


A new L-asparaginase with antitumour activity?


Vagotomy and acid secretion in gastric ulcer.


The YY syndrome.

The YY syndrome.


IgA and partial deletions of chromosome 18.


Basal insulin and obesity.

Basal insulin and obesity.


Gaucher cells in chronic granulocytic leukaemia.


A new sex-chromosome mosaicism.

A new sex-chromosome mosaicism.


The mammalian homologue of the avian bursa of Fabricius. I. Neonatal extirpation of Peyer's patch-type lymphoepithelial tissues in rabbits: methods and inhibition of development of humoral immunity.


Discussion in large classes via public-address system.


Chloroform anaesthesia. A clinical comparison of chloroform and halothane administered from precision vaporisers.


Cardiac arrhythmia during hypothermia controlled by propranolol.


A resumé of the current status of the development of plasma-cell tumors in mice.


Langat virus encephalitis in mice. I. The effect of the administration of specific antiserum.


A case of congenital indifference to pain (neurologic and psychiatric findings).


Hyaline reticuloxanthoma. The chemical nature of its hyaline.


Effect of diet, sulphonylureas, and phenformin on peripheral glucose uptake in diabetes and obesity.


The source of retinal emboli.

The source of retinal emboli.


Changes in ventilation, gas exchange, and circulation during exercise after recovery from myocardial infarction.


Coeliac-axis compression.

Coeliac-axis compression.


Serum-growth hormone and glucose intolerance in renal failure.


Oral maintenance therapy for pernicious anaemia.


Prospective leucocyte typing in cadaver renal transplantation.


Pharmacologic alteration of steroid hormone functions.


Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients.


Direct surgery in the treatment of posterior communicating aneurysms.


Addition of aminoacids to peritoneal-dialysis fluid.


Automated method for monitoring ventricular ectopic beats.


Personal and population medicine.

Personal and population medicine.


Running towards Olympus.

Running towards Olympus.


Breaking through on TV.

Breaking through on TV.


Abuse of methylamphetamine.

Abuse of methylamphetamine.


Type-IV hyperlipoproteinaemia.

Type-IV hyperlipoproteinaemia.


Saving the drop-out.

Saving the drop-out.


More medical scientists.

More medical scientists.


Health in the world of tomorrow.

Health in the world of tomorrow.


Cost and complexity of medicine.

Cost and complexity of medicine.


Ethical and social aspects of treatment of spina bifida.


Aspirins and enzymes.

Aspirins and enzymes.


X-rays and childhood cancer.

X-rays and childhood cancer.


Hodgkin's disease: a search for a definition.


Is Down's syndrome a modern disease?

Is Down's syndrome a modern disease?


Soya-bean oil in myocardial infarction.

Soya-bean oil in myocardial infarction.


Prophylactic lithium?

Prophylactic lithium?


Insulin antagonism in human serum.

Insulin antagonism in human serum.


Aspirin, vitamin-C deficiency, and gastric haemorrhage.


Oral contraceptives and the vital organs.


Foetoglobin and primary liver cancer.

Foetoglobin and primary liver cancer.


Methohexitone relaxation.

Methohexitone relaxation.


Methicillin-resistant staphylococci.

Methicillin-resistant staphylococci.


Employers' liability for cancer of the scrotum.


Looking for teaching aids?

Looking for teaching aids?


Treatment of baboon renal allotransplants with subcellular kidney cell antigens and other specific globulins.


Chronic hepatitis: effect of prolonged suppressive treatment and comparison of azathioprine with prednisolone.


Treatment of baboon renal allotransplants with subcellular kidney cell antigens and other specific globulins: histopathological observations.


Kidney cell fractions and immunoglobulins in baboon renal allotransplantation: serological observations.


Histopathological alterations in perfused,preserved and reinserted renal autotransplants.


Urticaria and angioedema.

Urticaria and angioedema.


Studies in myoclonus epilepsy (Lafora body form). I. Isolation and preliminary characterization of Lafora bodies in two cases.


Immune deposit diseases or of mink and mice. Possible analogies to the connective tissue disorders.


Special aids for the 1969 National Children's Dental Health Week. Bureau of Dental Health Education.


Endocrine function in emotionally disturbed and normal men.


Leprosy.

Leprosy.


Retinal histology in amaurotic idiocies and tapeto-retinal degenerations.


On masturbation: a study of Jean Genet's "Our Lady of the Flowers".


[Peculiarities of the function of the thyroid gland in leukoses and lymphogranulomatoses].


Antibody production in the frog.

Antibody production in the frog.


Spontaneous glomerulonephritis in sheep. II. Studies on natural history, occurrence in other species, and pathogenesis.


Prevention of tuberculous cavity formation by immunosuppressive drugs.


Serum levels of IgG, IgM, and IgA in rheumatoid arthritis.


Transient osteoporosis of the hip. A nontraumatic variety of Südeck's atrophy.


Chronic otitis media in the Southwestern American Indian. II. Immunologic factors.


Progressive ophthalmoplegia. Report of cases.


Phosphate treatment of hypercalcaemia due to carcinoma. Thirteen patients with hypercalcaemia due to carcinoma received inorganic phosphate, orally or intravenously, as palliative treatment for their high serum calcium levels. The serum calcium promptly fell in all patients fully treated, and there was a striking clinical improvement in most patients. The blood urea was usually unchanged or became nearer to normal, while the serum phosphate altered variably. Only two of the eight patients who were studied at necropsy had microscopical nephrocalcinosis; corneal calcification was evident in both before phosphate treatment was started.This oral inorganic phosphate (1 gramme thrice daily) is a safe and effective means of treating hypercalcaemia due to carcinoma. An intravenous infusion of 1 gramme over eight hours may sometimes be required initially for patients who are vomiting.


Four cases of rickettsial endocarditis.

Four cases of rickettsial endocarditis.


Serologic diagnosis of visceral larva migrans.


Studies of immune deposits in synovial membranes and corresponding synovial fluids.


Semiautomatic microtechnique for serial dilution-antibiotic sensitivity testing in the clinical laboratory.


Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states.


Isoelectric fractionation of proteins on a microscale in polyacrylamide and agarose matrices.


Growth in vitro of herpes simplex virus in human lymphoma cell lines.


Effect of horse serum, fetal calf serum, calf serum, bovine serum, and fetulin on neoplastic conversion and chromosomes of mouse embryo cells in vitro.


Squamous cell carcinoma of the bladder.

Squamous cell carcinoma of the bladder.


Studies on the metabolism of tryptophan in patients with benign prostatic hypertrophy or cancer of the prostate.


Fallot's tetralogy: a case study.

Fallot's tetralogy: a case study.


Senile cataract.

Senile cataract.


IgG-B1C cryoglobulins in acute glomerulonephritis.


Chemical cleavage of proteins. Selective fragmentations and modifications reveal structure.


Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S. The smaller fragment, with a molecular weight of about 15,000, possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for guinea pig ileum.


Morphology of the islets of Langerhans after ligation of the pancreatic duct in rats.


Three IgA myeloma immunoglobulins from the BALB/ mouse: precipitation with pneumococcal C polysaccharide. Three of 64 IgA immunoglobuilins, derived from plasma cell tumors induced by mineral oil in BALB/c mice, precipitated with species-specific pneumococcus C polysaccharide. A related antigen was also found in group O and some group H streptococci. A difference in ability to precipitate a C polysaccharide from a pneumococcus type XIV was demonstrated between protein 603 which did precipitate and protein 167 which did not precipitate this polysaccharide. Studies of the 167 and 603 proteins showed differences in electrophoretic mobility and polypeptide chains. The antigen-combining site of the 167 and 603 proteins resided on the papain-digestion Fab fragment.


The endocrine pancreas of old obesehyperglycemic mice.


The treatment of lung cancer by split-dose irradiation.


Probability values for protein bound iodine, thyroid I-131 uptakes and T3 resin uptakes for hypothyroidism, euthyroidism and hyperthyroidism.


Electrocardiographic changes following diaphragmatic inspiration.


Some aspects of chemotherapy in breast carcinomatosis.


Secondary syphilis with unusual clinical and laboratory findings.


Pathologic findings in a case of cardiac transplantation.


Escherichia coli serotypes in urinary-tract infection in a medical ward.


Effect of saline infusion on protein excretion before, during, and after surgery.


Gastric iron binding in haemochromatosis, secondary iron overload, cirrhosis, and diabetes.


Treatment of acute paracetamol poisoning.


Abnormalities in IgA-containing mononuclear cells in the gastric lesion of pernicious anaemia.


Propranolol and iodine-131 in the management of thyrotoxicosis.


Metachromasia and skin-fibroblast cultures in juvenile familial amaurotic idiocy.


Exanthematous disease in patas monkeys caused by a herpes virus.


Hope for an undernourished world.

Hope for an undernourished world.


Bacteria and the skin.

Bacteria and the skin.


Rubella.

Rubella.


Developing paediatricians.

Developing paediatricians.


Aids for the disabled.

Aids for the disabled.


Propranolol in hyperthyroidism.

Propranolol in hyperthyroidism.


Apologia.

Apologia.


Typhoid fever in the previously immunised.


Malaria and population explosion.

Malaria and population explosion.


Cyclic regimen for childhood leukaemia.

Cyclic regimen for childhood leukaemia.


Cross-circulation between man and baboon in hepatic coma.


Asthmatic breathing in mice.

Asthmatic breathing in mice.


Aggression and the XXYY anomaly.

Aggression and the XXYY anomaly.


Radiation dose in isotope encephalography.


Methicillin-resistant staphylococci.

Methicillin-resistant staphylococci.


Tachycardia and neuropathy of porphyria.


Heat-stress and renal failure.

Heat-stress and renal failure.


Electrolyte abnormalities in porphyria.

Electrolyte abnormalities in porphyria.


Management of cervical carcinoma-in-situ.


Carcinoma of colon and rectum.

Carcinoma of colon and rectum.


Effect of ethacrynic acid and other diuretics on glucose utilisation by adipose tissue.


Species insulin information.

Species insulin information.


Insulin response in thyroid disease.

Insulin response in thyroid disease.


Allergic reaction to B.C.G.

Allergic reaction to B.C.G.


Chloroquine blindness?

Chloroquine blindness?


Hodgkin's disease.

Hodgkin's disease.


Mussel poisoning.

Mussel poisoning.


The definition of asthma.

The definition of asthma.


Methohexitone relaxation.

Methohexitone relaxation.


Procarbazine and cheese.

Procarbazine and cheese.


The nurse's uniform symbolic or sacrosanct?


The effect of thiouracil and excess thyroxine on the hypothalamus of the rat with special reference to neurosecretory phenomena.


Non-thermal effect of microwave radiation in vitro on peritoneal mast cells of the rat.


[Synthesis of actinomycin related compounds. I].


Observations on the chromatinic bodies of two species of the actinoplanaceae.


Structural features of mesosomes (chondrioids) of Bacillu subtilis after freeze-etching. Freeze-etched cells of Bacillus subtilis have been studied with the electron microscope. The outer surface of the plasma membrane, i.e. the side facing the cell wall, is covered with numerous granules and short strands, each measuring approximately 50 A in diameter. These strands are occasionally seen to enter the cell wall. The inner surface of the plasma membrane, i.e. the side facing the cytoplasm, appears to be sparsely dotted with small particles measuring about 50 A. The envelope of mesosomes differs from the plasma membrane. Blunt protrusions arise from its outer surface; the inner surface appears smooth. Stalked particles, as described by other investigators after negative staining with phosphotungstic acid, were not observed on any membrane surface in our material. Preparations were also made of specimens prefixed in osmium tetroxide prior to freeze-etching. Under these conditions the bacterial membranes appeared to be surprisingly well preserved. In contrast to directly frozen, unfixed cells, some osmium tetroxide-fixed preparations showed a differentiation in cytoplasm and nucleoplasm, which made it possible to observe the close association of the mesosome with the latter.


The localization of enzyme activities by substrate film methods--evaluation and perspectives.


Gaucher's disease: abnormalities in immunoglobulins.


Immunological studies of submaxillary saliva from patients with cystic fibrosis and from normal children.


IgA deficiency and susceptibility to infection.


Allergic reactions to tetanus toxoid.

Allergic reactions to tetanus toxoid.


Drugs which affect the structure and function of DNA.


[Histochemical studies on Gomori-positive substances. IV. Gomori-positive material in the paraventricular organ of various vertebrates].


The nucleus of the paraventricular organ and its fibre connections in the domestic fowl (Gallus domsticus).


A unique lymphoproliferative disorder associated with an IgM platelet agglutinin, diffuse hypergammaglobulinemia, amyloid deposition and excessive urinary excretion of IgG fragments.


A method of management of inoperable carcinoma of the bladder.


Aids for the partially sighted.

Aids for the partially sighted.


Diabetic retinopathy: newer concepts of its pathology and treatment.


Rare forms of paraproteinaemia: a case of gamma-D myeloma.


Some facts on the problem of the appearance and quantitative relationships of the beta-2 immune globulins.


New diazo reagent for specific staining of conjugated bilirubin in tissue sections.


Histologic and immunofluorescent studies on the site of origin of glucagon in mammalian pancreas.


A ninhydrin histochemical test specific for hair keratin.


Cytochemical demonstration of basic proteins by Dansyl staining.


Characterization of the nuclei of Ehrlich ascites carcinoma by means of quantitative cytochemistry.


Chick bioassay of vitamin K compounds using dicumarol and pivalyl as anticoagulants.


Evaluation of gastric lavage cytology under direct vision by the fibergastroscope employing Hanks' solution as a washing solution.


Free thyroid hormones: "free thyroxine".


Excretory urography before prostatectomy.


Prostatic obstruction in Singapore.

Prostatic obstruction in Singapore.


Laboratory suggestion: coverslip staining rack.


Simple preparation of acid-fast and fungus stain control slides.


Rh immunoglobulin and its use in preventing erythroblastosis.


A new gold stain for astrocytes.

A new gold stain for astrocytes.


Reducing absenteeism resulting from upper respiratory complaints.


The neonatal thymus and immune paresis.

The neonatal thymus and immune paresis.


Secondary antibody deficiency.

Secondary antibody deficiency.


Effect of incubation in Krebs-Ringer solution or humid air on the amine content, fluorescence and staining characteristics of the duodenal enterochromaffin and dopamine cells.


Isolation and identification of immune globulins in the opposum (Didelphys virginiana).


The immunoglobulin response of rats to Amplicaecum robertsi infestations.


Fixation and sensitizing capacity in the guinea pig of horse IgA, rabbit and chicken IgG.


The hydrostatic mechanism of papilledema.


Effect of serotonin and antiserotonin substances on the thyroxine-binding capacity of serum protein fractions.


Coccidioidal granuloma of lid.

Coccidioidal granuloma of lid.


Effect on fat metabolism of a new heparinoid of fungal origin.


Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study.


An electron microscopic study of intracellularly stained neurons.


On the structure of the actinomycin-DNA complex.


Interaction of different classes of antibiotics with nucleic acids.


Action of acridine dyes and related compounds on nucleic acid synthesis and active transport in tissue culture cells.


The amino acid sequence of the Fc fragment of rabbit immunoglobulin G. I. The isolation and amino acid composition of tryptic peptides.


The amino acid sequence of the Fc fragment of rabbit immunoglobulin G. II. Cleavage of the Fc fragment with cyanogen bromide.


Study of macromolecular interactions by equilibrium molecular sieving.


Prevention of rheusus iso-immunization.

Prevention of rheusus iso-immunization.


IgG anti-D in prevention of rhesus iso-immunization--a second report and review of 100 pregnancies.


Sulfur dioxide and acute effects of air pollution.


Dermatologic autoimmunity.

Dermatologic autoimmunity.


Dissociation of [3H]cholesterol and 125I-labelled plasma protein influx in normal and atheromatous rabbit aorta. A quantitative histochemical study.


Increase of gamma g-globulin in coronary heart disease.


A new technique for making häutchen preparations of unfixed aortic endothelium.


Constriction (banding) of Blalock-Taussig anastomosis for intractable congestive cardiac failure and pulmonary oedema.


A study of an inhibitor in bovine serum active against respiratory syncytial virus.


Isolation and characterization of kappa and lambda chains of normal human gammaG-immunoglobulin.


Different ratios of the LDD and DDD diastereoisomers of phytanic acid in patients with Refsum's disease.


Clinical application of acid elution technique to estimate the degree of transplacental foeto-maternal transfusion in pregnancy.


The staining mechanism of aldehyde-fuchsin, with reference to the oxytalan fiber in the mouse.


Cytofluorometric determination of lysine with dansylchloride.


Intracristal localization of succinic dehydrogenase activity with a new osmium-containing tetra-tetrazolium salt.


The histamine-binding property of serum.


The protective effect of different immunoglobulins against herpetic encephalitis and skin infection in guinea pigs.


Acridine orange staining of monkey kidney cells infected with adenoviruses and their associated viruses.


Disc plate assay of vaccinia antibodies.


On the nature of the cystine-dependent phenotype of poliovirus.


Characterization of messenger RNA in protoplasts of Saccharomyces carlsbergensis.


The rare phenotype Gm (-1,2) in three generations.


Stimulation of DNA synthesis in the culture of mouse spleen cells by means of heterologous antilymphocytic and antiglobulin sera.


Application of the Giemsa stain for sugarcane and corn mosaic and streak diseased tissues.


Operation, external irradiation, radioactive isotopes, and chemotherapy in treatment of metastatic ovarian malignancies.


Serum antinuclear antibodies in progressive systemic sclerosis (scleroderma).


Review of fifty-four subjects with monoclonal gammopathy.


Suppressing Rh-immunization.

Suppressing Rh-immunization.


Rh-immunization by pregnancy: results of a survey and their relevance to prophylactic therapy. A series of Rh-negative primiparae has been studied in order to gain further insight into the process of immunization by pregnancy. The distribution of foetal cell counts in blood samples taken after delivery was determined for 2,029 mothers giving birth to ABO-compatible babies and for 417 mothers with ABO-incompatible babies.A total of 760 mothers were tested for the development of Rh antibodies six months after the delivery of an ABO-compatible Rh-positive baby and 236 were further followed up through a second Rh-positive pregnancy. The incidence of anti-D six months after delivery is estimated to be 8.5%, and there is evidence of a direct relation between the count of foetal cells after delivery and the risk of developing antibodies. A further 8.5% of mothers were estimated to develop anti-D by the end of the second pregnancy, and it is postulated that these individuals had been primed by the first pregnancy. There is some evidence that the larger stimuli of Rh-positive blood in the first pregnancy are more likely to result in overt antibody formation, while the smaller stimuli are more likely to prime, antibodies not being detected until a second stimulus occurs during the second pregnancy.These findings are relevant to the programme for preventing Rh-immunization by injecting anti-D gammaglobulin.


The prostaglandins.

The prostaglandins.


Antibodies to echovirus type 30 in the Canadian population.


Natural synchrony in the slime mould Physarum polycephalum.


Sex hormones in the Middle Ages.

Sex hormones in the Middle Ages.


Amyloid. IV. Is human amyloid immunogenic?


Physical and psychological development of children with early failure to thrive.


Electrophoretic mobility of guinea pig peritoneal exudate cells in hypersensitivity reactions.


Thymic alymphoplasia associated with the hemolytic-uremic syndrome.


Palliative balloon atrial septostomy for total anomalous pulmonary venous connection in infancy.


Whipple's disease presenting with ocular inflammation and minimal intestinal symptoms.


Total salvage in adenocarcinoma of the rectum and rectosigmoid.


Immunoglobulin synthesis in a cell-free system.


Morphology of bovine viral diarrhoea virus.


A method of preparing fungus controls.

A method of preparing fungus controls.


The chemical composition of wool. 7. Separation and analysis of orthocortex and paracortex.


Artificial histidine-containing mutants of tobacco mosaic virus.


The amino-terminal sequence of the heavy chain of human immunoglobulin M.


Differential sedimentation coefficients. I. Precise measurement. Determination of concentration dependence for IgG-immunoglobulin.


The nature of myeloma proteins.

The nature of myeloma proteins.


A temperate bacteriophage of Clostridium perfringens.


Selective staining of secretory granules of adrenal medullary cells by silver methenamine: a light and electron microscopic study.


Immunoglobulin E: a new class of human immunoglobulin.


Experimental immune inflammation in the synovial membrane. I. The immunological mechanism.


Immunoglobulin class of antibodies to cow's milk casein in infant sera and evidence for low molecular weight IgM antibodies.


Immunological responses of the toad, Xenopus laevis, to the antigens of the ciliate, Tetrahymena pyriformis.


Study of precipitating antibodies in Coombs sera by agar gel diffusion.


Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases.


Ferritin-antibody localization of erythrocyte antigenic sites in immunohemolytic anemias.


Hypersensitivity to Ascaris antigens. IV. Production of homocytotropic antibodies in the rat.


Biologic properties of rat antibodies. I. Antigen-binding by four classes of anti-DNP antibodies.


Types of canine serum immunoglobulins.

Types of canine serum immunoglobulins.


Catabolism of human gamma-G immunoglobulins of different heavy chain subclasses. II. Catabolism of gamma-G myeloma proteins in heterologous species.


Immunoglobulins produced in response to Japanese encephalitis virus infections of man.


Anti-nuclear antibodies in mice. I. Influence of age and possible genetic factors on spontaneous and induced responses.


Nonspecific stimulation of antibody production in  surgically bursectomized chickens by bursa-containing diffusion chambers.


Immunological aspects of premature ovarian failure associated with idiopathic Addison's disease.


Autoantibody-containing cells in the gastric mucosa in pernicious anaemia.


Insulin reserve in patients with chronic pancreatitis.


Effect of thyroid funtion and of obesity on discriminant function for mammary carcinoma.


Platelet-phosphohexokinase levels in Down's syndrome.


Cutaneous leishmaniasis of the guineapig. Action of sensitised lymphocytes on infected macrophages.


Safety in biliary-tract surgery.

Safety in biliary-tract surgery.


Unsaturated fats and coronary heart disease.


Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin.


Smoking and pregnancy.

Smoking and pregnancy.


Domiciliary midwifery in Wolverhampton.

Domiciliary midwifery in Wolverhampton.


Clinical significance of deaths after discharge from hospital unrecorded in the hospital notes.


Treatment of pathological fracture of the femur.


Corticosteroids for spinal metastases.

Corticosteroids for spinal metastases.


Emotion and non-specific infection as possible aetiological factors in Graves' disease.


Laparoscopy and ovulation.

Laparoscopy and ovulation.


Immunofluorescent study of the vervet monkey disease agent.


Secretin and pancreozymin-cholecystokinin after glucose.


Aseptic methods in the operating-theatre.


Scanning electron microscopy of rat intestinal microvilli.


Disposable surgical gloves.

Disposable surgical gloves.


Pregnancy after aortic valve prothesis.

Pregnancy after aortic valve prothesis.


Inhibition of renal tubular reabsorption of homocystine by lysine and arginine.


Lepromatous leprosy.

Lepromatous leprosy.


D.N.A. in retinoblastoma.

D.N.A. in retinoblastoma.


A thrombocytopoietic factor in embryonic liver.


A new polydactyly/imperforate-anus/vertebral-anomalies syndrome.


Resistance of the rabbit to streptozotocin.


Operating-suite climates.

Operating-suite climates.


Papilloedema in Guillain-Barré syndrome.


Insulin and atherosclerosis.

Insulin and atherosclerosis.


Fibrin deposits on the syncytium of the normal human placenta: evidence of their thrombogenic origin.


Studies on the pancreatic A1-cells and their reactions to gastrin administration.


Diffuse corneal staining from dermatological therapy. A contact lens symptom artifact.


Phosphate carrier of rat-liver mitochondria: its role in phosphate outflow.


Objective assessment of nasal airway in children: an evaluation of decongestant therapy.


Immunoglobulins G, A, and M in systemic lupus erythematosus. Relationship to serum complement titer, latex titer, antinuclear antibody, and manifestations of clinical disease.


ISG recommended for infectious hepatitis.


Pyridine nucleotide stimulation of lipid phosphorylation.


Mechanism of urinary continence. I. Embryologic, anatomic and pathologic considerations.


Nephroblastoma--Wilms' tumour.

Nephroblastoma--Wilms' tumour.


Psychiatric aspects of learning problems.


A study of factors controlling activity of neurons within the paraventricular, supraoptic and ventromedian nuclei of the hypothalamus.


Demonstration of spermatozoa in stains on wood by a histochemical technique.


Ultrastructure of sonic and digitonin fragments from beef heart mitochondria.


Reversible photoreduction of chlorophyll a to a compound, Ch-a-H2 610, with an absorption maximum at 610 nm.


The effect of the absence of corneal epithelium or endothelium on the stromal keratocytes.


Retinal arteriolar annuli.

Retinal arteriolar annuli.


Incidence and pathology of Spirocerca lupi in Kenya.


Immunoglobulin binding by the miracidia of Fasciola hepatica.


Tumours of the endocrine glands in cattle, sheep and pigs found in a British abattoir survey.


Further observations on histochemical changes in scrapie mouse brain. Comparison with experimental viral encephalitides.


Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components. Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.


Cells involved in the immune response. IV. The response of normal and immune rabbit bone marrow and lymphoid tissue lymphocytes to antigens in vitro. Cell suspensions of immune rabbit lymph nodes and spleen were capable of undergoing blastogenesis and mitosis and of incorporating tritiated thymidine when maintained in culture with the specific antigen in vitro. They did not respond to other, non-cross-reacting antigens. The blastogenic response obtained with immune lymph node cells could be correlated with the antibody synthesizing capacity of fragment cultures prepared from the same lymph nodes. Cell suspensions of immune bone marrow responded to non-cross-reacting antigens only whereas cell suspensions of immune thymus, sacculus rotundus, and appendix did not respond when exposed to any of the antigens tested. On the other hand, neither fragments nor cell suspensions prepared from lymph nodes, spleen, and thymus of normal, unimmunized rabbits responded with antibody formation and blastogenesis when exposed to any of the antigens. However, normal bone marrow cells responded with marked blastogenesis and tritiated thymidine uptake. The specificity of this in vitro bone marrow response was demonstrated by the fact that the injection of a protein antigen in vivo resulted in the loss of reactivity by the marrow cell to that particular antigen but not to the other, non-cross-reacting antigens. Furthermore, bone marrow cells of tolerant rabbits failed to respond to the specific antigen in vitro. It was also demonstrated that normal bone marrow cells incubated with antigen are capable of forming antibody which could be detected by the fluorescent antibody technique. This response of the bone marrow cells has been localized to the lymphocyte-rich fraction of the bone marrow. It is concluded that the bone marrow lymphocyte, by virtue of its capacity to react with blastogenesis and mitosis and with antibody formation upon initial exposure to the antigen, a capacity not possessed by lymphocytes of the other lymphoid organs, has a preeminent role in the sequence of cellular events culminating in antibody formation.


The effect of acetylsalicyclic acid on platelet function. Acetylsalicylic acid (ASA, aspirin) and sodium salicylate inhibit platelet aggregation induced by collagen, antigen-antibody complexes, gamma globulin-coated particles or thrombin. These compounds suppress the release of platelet constituents, such as adenosine diphosphate (ADP) and serotonin, induced by such stimuli. Since ASA and sodium salicylate do not inhibit ADP-induced platelet aggregation, it appears that their effect on the action of the other stimuli is due to a decrease in the amount of ADP released. The administration of ASA to rabbits (in doses which inhibited collagen-induced platelet aggregation) impaired hemostasis, prolonged platelet survival, and diminished the amount of deposit formed in an extracorporeal shunt.


The individual antigenic specificity of antibodies to streptococcal carbohydrates. Although a single electrophoretically uniform antibody component with specificity for the group carbohydrate may comprise the bulk of the gamma-globulin in rabbits immunized with streptococcal vaccines, this is not always the case. Not infrequently, electrophoresis may reveal multiple antibody components. Nevertheless, it has been feasible by various preparative procedures to isolate from a single antiserum at least two antibody components with similar reactivity for the carbohydrate both of which are electrophoretically monodisperse. Light chains from such antibodies reveal a restricted pattern when examined by disc electrophoresis. Antibodies to streptococcal carbohydrates have been examined for their individual antigenic specificity. Goats were immunized with isolated Group C and Group A-variant antibodies raised in rabbits. Individual antigenic specificity of these antibodies was brought out by absorption of the goat anti-antiserum with Fr II of pooled normal rabbit sera. Additional absorption of the goat anti-antisera with Fr II diminished but did not eliminate the reactivity for the homologous antibody. Immunoelectrophoretic studies with papain fragments of purified streptococcal antibodies localized the specificity to the Fab fragment. Specificity was not confined to the isolated light chains of the antibody.


Receptors for complement of leukocytes.

Receptors for complement of leukocytes. Sheep red blood cells sensitized by 7S, but not by 19S rabbit anti-Forssman antibodies, adhere and form rosettes on mouse macrophages and on a few monocytes and polymorphonuclear cells (PMN). When, however, C' factors from mouse serum are added to the antigen-19S antibody complex (EAC'), rosettes are formed on most mouse peritoneal macrophages and PMN and on a few monocytes. In addition EAC' also adheres to 10-25% of lymph node lymphocytes but not to thymus lymphocytes. EAC' prepared with 7S anti-Forssman antibodies has identical properties. The adherence of red cells induces an increase in the membrane activity of the leukocytes and causes injury to the red cells which rapidly become deformed and fragmented. Adherence of EAC' occurs at 37 degrees C and is minimal at 4 degrees C. Probably only the first four C' components are involved in this phenomenon as mouse serum deficient in C'5 or rabbit serum, deficient in C'6 can be used as a source of C' components. Treatment of EAC' with EDTA does not modify its leukocyte-adherence properties. The adherence of EAC' to the leukocytes is not inhibited in the presence of serum. The receptors for C' on macrophages, PMN, and monocytes differ from those found on lymphocytes. Rosette formation by EAC' on macrophages, PMN, and monocytes depends on divalent cations (Mg(++)) and can be reversed by Na(3)H EDTA, while adherence to lymphocytes is independent of these ions and occurs in the presence of 0.01 M Na(3)H EDTA. Both types of receptors for C' components are destroyed by trypsin treatment of the leukocytes, in contrast with the receptors for 7S antibodies on the same cells which persist after enzyme treatment.


Results of resection for oat-cell carcinoma of the lung.


Cadaveric renal transplantation.

Cadaveric renal transplantation.


Hepatic dysfunction associated with renal transplantation.


Intranasally administered rubella vaccine.


Rubella virus and human lymphocytes in culture.


Pituitary-adrenal function tests in patients with untreated pituitary tumours.


Pre-cancerous changes in bladder epithelium.


Choroquine-resistant Plasmodium falciparum malaria in the United Kingdom.


Hypercalcaemia from calcium ion-exchange resin in patients on regular haemodialysis.


Hypercalcaemia from calcium resin in patients with chronic renal failure.


Lymphocyte viraemia in congenital rubella.


Aluminium resin for the treatment of the hyperkalamia of renal failure.


A simplified cardiac resuscitation trolley for ward use.


Defect in urinary acidification in adults with sickle-cell anaemia.


Corticosteroids and the liver.

Corticosteroids and the liver.


Defence at Porton.

Defence at Porton.


Dropped finger.

Dropped finger.


Scarcity of primates.

Scarcity of primates.


Adoption.

Adoption.


Regional policy for hospital disinfection and sterilisation.


An amateur opines.

An amateur opines.


Community services for mentally infirm old people.


Children at risk.

Children at risk.


A mature student's observations on examiner's technique.


XXYY with manic-depression.

XXYY with manic-depression.


Fluid deprivation in large-dose urography.


Electrolyte abnormalities in porphyria.

Electrolyte abnormalities in porphyria.


Effects of oestrogen-gonadotrophins treatment.


Distal potassium secretion in man.

Distal potassium secretion in man.


Metabolism of bilirubin in the Gunn rat.


Haemolytic-uraemic syndrome.

Haemolytic-uraemic syndrome.


Primary hyponatraemia of infancy?

Primary hyponatraemia of infancy?


Blastosis during anti-lymphocyte-globulin treatment.


Mussel poisoning.

Mussel poisoning.


Plasmapheresis and positive-pressure ventilation in hepatic coma with respiratory arrest.


Folic-acid absorption in man.

Folic-acid absorption in man.


Phenobarbitone and neonatal jaundice.

Phenobarbitone and neonatal jaundice.


Clioquinol and thyroid-function assessment.


In-vitro activation and reinfusion of autologous human lymphocytes.


Coroner's post-mortem order upheld against religious beliefs.


Stefan Jellnek. M. D. Vienna.

Stefan Jellnek. M. D. Vienna.


Norman Frederick Hallows. D.M. Oxon., M.R.C.P.


Iwo Robert W. Lominski. M.D. Cracow, D. Sc. Glasg., F.R.C.P.G., F.R.S.E.


A Freudian reading of Keats's Ode To Psyche.


Effect of monthly gamma-globulin administration on the serum gamma-globulin level of premature infants.


The effect of conflicting uncoditioned reflexes on serum cholesterol level in the rat.


Preparative separation of fibrinogen, gamma globulins, transferrin, albumin and ceruloplasmin from a single sample of plasma.


An artefact caused by the binding of protein to dextran gel.


Immunoglobulins and disease.

Immunoglobulins and disease.


Histochemical studies on papillary hyperplasia of the palate. I. Metachromasia, mast cells, acid mucopolysaccharides, and glycogen.


Study of glycogen content and "basement membrane" in benign and malignant oral lesions.


Antinuclear antibodies in Coombs-positive acquired hemolytic anemia.


Erythrophagocytosis in vitro. I. Specificity and sensitivity.


Complicated communications challenge the church and chaplains.


Pathogenesis of gastric microcirculatory and mast cell changes in restraint stress.


The synthesis of immunoglobulin-g by cultured human lymphocytes.


The development of selectivity of protein absorption from the intestine during suckling in the rat.


The determination of glucosamine and galactosamine in some glycoproteins by radioisotope dilution. 1. The principle of radioisotope dilution was applied on a semi-micro scale to the determination of glucosamine and galactosamine in some glycoproteins, such as immunoglobulins, a urinary glycoprotein and blood-group-specific substances. 2. The glycoprotein was hydrolysed in the presence of [1-(14)C]glucosamine or [1-(14)C]galactosamine or both. The amino sugars were made to react with naphthyl isothiocyanate and the products formed were isolated by the method of Scott (1962). The specific radioactivities determined from liquid-scintillation counting and the extinction at 240mmu or 222mmu were used to calculate the content of amino sugars in the protein analysed. 3. Where the values could be compared with those found by other workers, differences were in general not very great. The advantages of the method are that high concentrations of acid can be employed and undesirable side reactions, which may occur with the free sugars, do not affect the results. A potential source of error of the method is discussed.


A reliable staining method for semi-thin sections in experimental neurfanatomy.


Paradoxical interocular transfer of mirror-image discriminations in the optic chiasm sectioned monkey.


Nuclear structures in nerve cells in multiple sclerosis.


The corticothalamic projection from the pericruciate and coronal gyri in the cat. An experimental study with silver-impregnation methods.


Visualizing your presentation.

Visualizing your presentation.


Deposition of janus green b and pinocyanol in mitochondria of supravitally stained KB cells.


Twinning of sea urchin embryos by treatment with dithiothreitol. Roles of cell surface interactions and of the hyaline layer.


Cortical fibers in fertilized eggs of the sea urchin Strongylocentrotus purpuratus.


Clinical experiences with computerized monitoring of cardiovascular variables in the postoperative thoracic patient.


Granule-lamella complex in monkey renal proximal tubular cells.


Cytochemical differentiation of the guinea pig sperm flagellum with phosphotungstic acid.


Effects of clofibrate on fibrinolysis, platelet stickiness, plasma-fibrinogen, and serum-cholesterol.


Urinary excretion of calcium and other electrolytes in renal lithiasis.


Electron microscopical observations on the surface coating of human blood platelets.


Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis.


Cholera carriers in a Calcutta slum.

Cholera carriers in a Calcutta slum.


Cytotoxins released from plastic perfusion apparatus.


Nitrosamines in African alcoholic spirits and oesophageal cancer.


Distribution of alcohol in urine and sweat after drinking.


Electrocardiographic transmissions by public telephone.


Glucagon.

Glucagon.


Disinfection of ventilators by ultrasonic nebulisation.


Vaccination against mumps.

Vaccination against mumps.


General practitioner and obstetrician.

General practitioner and obstetrician.


The origins of violence.

The origins of violence.


Foetal circulation and asphyxia.

Foetal circulation and asphyxia.


Advice on abortion.

Advice on abortion.


A ten-year cervical-smear screening programme.


Sewage disposal.

Sewage disposal.


Safety of domiciliary midwifery.

Safety of domiciliary midwifery.


Talking about addiction.

Talking about addiction.


Matching blood for recipients of dextrans.


Ethical and social aspects of treatment of spina bifida.


Methohexitone relaxation.

Methohexitone relaxation.


Ejection of D.N.A.-containing macrostrands from nuclei of lymphocytes.


Coffee, alcohol, and liver enzymes.

Coffee, alcohol, and liver enzymes.


Arginine infusion and growth-hormone secretion.


Methicillin-resistant staphylococci.

Methicillin-resistant staphylococci.


Caeruloplasmin and green plasma.

Caeruloplasmin and green plasma.


Hypoglycaemia in pancreatitis.

Hypoglycaemia in pancreatitis.


General practitioners and the hospital service.


Chloroquine blindness?

Chloroquine blindness?


R. N. A. Synthetic activity of human oocyte.


Environmental temperature and death-rate of women from breast neoplasms.


Reports on congenital abnormalities.

Reports on congenital abnormalities.


Chromosomes of tall men in mental hospitals.


Chromosome studies in primary sterility.


Emotional problems and reactions of the medical team in a chronic haemodialysis unit.


Complications of depressed skull fracture.


The care of the dying.

The care of the dying.


Pregnancy in patients with hepatic cirrhosis. Management and outcome.


The neurosecretory cells of the brain of Aedes aegypti in relation to larval molt, metamorphosis and ovarian development.


Maintenance of the morphology of rat bone marrow leukocytes during cytochemical staining for lactate dehydrogenase activity.


Role of the thymus in tolerance. VII. Distribution of nonaggregated and heat-aggregated bovine gamma globulin in lymphoid organs of normal newborn and adult rats.


Hyperkinesis--revisited.

Hyperkinesis--revisited.


Notes on morphologically less usual forms of chronic lymphadenosis.


Granulocytic alkaline phosphatse in the inflammatory exudate.


Exchange transport of sugars in erythrocytes of patients suffering from hereditary spherocytosis.


The protective influence of haptoglobin on hemoglobinuric kidney. I. Bioch- emical and macroscopic observations.


Preliminary attempts at ultrastructural sulfhydryl demonstration.


Some remarks to the Sterba's fluorescent method in application to the neurosecretory cells.


Feulgen-DNA changes in rat liver cell nuclei during the early phase of ischaemic necrosis.