Differentiation within the bacterial flagellum and isolation of the proximal hook. Purified and crude flagellar isolates from cells of Bacillus pumilus NRS 236 were treated with acid, alcohol, acid-alcohol, or heat, and were examined electron microscopically in negatively stained and shadow-cast preparations. Under certain conditions, each of these agents causes the flagella to break between the proximal hooks and the spiral filaments. In such preparations, filaments are seen in various stages of disintegration, whereas hooks of fairly constant length retain their integrity and morphological identity. When crude isolates of flagella are treated under these conditions, the hooks remain attached to membrane fragments or bear basal material. These findings substantiate previous structural observations that led to the view that the proximal hook is a distinct part of the bacterial flagellum and further confirm that the hook is tightly associated with basal material and the cytoplasmic membrane. It appears that the hook is a polarly oriented structure, and that the interactions between the hook and the basal material or the cytoplasmic membrane are different from those between the hook and the filamentous portion of the organelle. Moreover, both types of interaction apparently differ still from those by which the flagellin subunits are held together in the flagellar filament. Hooks were isolated by exploiting the differences in relative stability shown by the various morphological regions of the bacterial flagellum.


Surface structure of streptomycete spores as revealed by negative staining and freeze-etching. The application of a simple negative staining technique and freeze-etching has revealed detailed information on the species-specific surface structure of spores and aerial hyphae of streptomycetes.


Tendon and ligament insertion. A light and electron microscopic study.


New method for control of immunologic problems from the Rh-incompatible pregnancy.


Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. We have investigated the formation of fibrin, platelet aggregates, and subendothelial deposits in lipoid nephrosis. Fibrin formation was found in 10 cases of active lipoid nephrosis. Platelet aggregates were found in eight cases and subendothelial deposits in nine. Fibrin and platelets were also found in cases of nephrotic syndrome due to other causes, and in glomerulonephritis. Fibrin was generally absent in lipoid nephrosis in remission and in benign recurrent hematuria. It is suggested that what seems to be a lower incidence in females is more apparent than real and that fibrin or related material may be present in a less easily identifiable form. Steroid therapy apparently had no effect on the presence or absence of fibrin. Most instances were associated with elevated serum cholesterol and alpha(2)-globulin. It is suggested that elevated serum lipids as well as the disease process in the kidney play a role in this phenomenon. It is further suggested that intraglomerular fibrin formation could lead to irreversible renal damage in lipoid nephrosis.


Breast cancer and reproductive history of women in South Wales.


Rhabdomyosarcoma of the paratesticular tissues in children. Report of eight cases.


Therapeutic abortion using prostaglandin F2alpha.


Renin secretion in renal hypertension.

Renin secretion in renal hypertension.


Adult coeliac disease in hyposplenic patients.


Antigen-binding lymphocytes in human blood.


Immunosuppressive effects of heterologous antilymphocyte serum in monkeys.


Results of kidney transplantation.

Results of kidney transplantation.


Portable laminar-air-flow isolator.

Portable laminar-air-flow isolator.


Hypoglycaemia in children with kwashiorkor.


Osteoporosis.

Osteoporosis.


Treatment of central retinal vein thrombosis with ancrod.


Hospital, press, and public.

Hospital, press, and public.


Diet and vascular disease.

Diet and vascular disease.


Ventilation and bacterial spread in hospital.


Amoebic meningitis.

Amoebic meningitis.


What kind of university?

What kind of university?


Function of the school doctor.

Function of the school doctor.


Defective adaptor delays resuscitation.

Defective adaptor delays resuscitation.


Press and profession.

Press and profession.


Bicarbonate and cerebral blood-flow.

Bicarbonate and cerebral blood-flow.


Rifamycin antibiotics in chronic bronchitis.


Intra-abdominal bleeding complicating peritoneal dialysis.


Prostaglandins for induction of therapeutic abortion.


Vasectomy and A.I.H.

Vasectomy and A.I.H.


Dangers of decimals.

Dangers of decimals.


Leech out of reach.

Leech out of reach.


Treatment of essential hyperlipidaemia.

Treatment of essential hyperlipidaemia.


Creatinine excretion.

Creatinine excretion.


Misdirected money-raising?

Misdirected money-raising?


Hospital staffing structure.

Hospital staffing structure.


Subluxation of the sacroiliac joint.

Subluxation of the sacroiliac joint.


Oral lignocaine.

Oral lignocaine.


Ampicillin rashes.

Ampicillin rashes.


Hospital milk kitchen.

Hospital milk kitchen.


Australia antigen in Rumania.

Australia antigen in Rumania.


Leukaemia and immune response.

Leukaemia and immune response.


Resuscitation ambulances.

Resuscitation ambulances.


Small-for-dates babies and the pill.

Small-for-dates babies and the pill.


Post-exercise ketosis.

Post-exercise ketosis.


Viraemia in rabies.

Viraemia in rabies.


Appeal to doctors.

Appeal to doctors.


Idiopathic thrombocytopenic purpura and low blood-iodine.


Treatment of acute prophyria variegata with propranolol.


John, 17 months.

John, 17 months.


Early diagnosis of cancer of the breast.


Death penalty.

Death penalty.


Treatment of acute lithium intoxication.


Serum-free-fatty-acids and arrhythmias after acute myocardial infarction.


Arthur Thomas Paterson, M.D. Edin., F.R.C.S.E., D.P.H.


Henry Joseph Brennan, M.D. Manc., F.F.A.R.C.S.


Controlled trial of amantadine hydrochloride in Parkinson's disease.


In-vitro activity of twelve antibacterial agents against Neisseria gonorrhoeae.


Neonatal coagulation defect due to anticonvulsant drug treatment in pregnancy.


Saddle pulmonary embolism: a surgical emergency?


Suppression of oestradiol secretion and luteinising-hormone release during oestrogen-progestagen oral contraceptive therapy.


Normal child after maternal thalidomide ingestion in critical period of pregnancy.


A disposable bath.

A disposable bath.


When to operate on the rheumatic mitral valve.


Gonorrhoea.

Gonorrhoea.


A health services research council?

A health services research council?


Winter and heart-disease.

Winter and heart-disease.


Attack on smallpox.

Attack on smallpox.


Outcome of acute otitis media.

Outcome of acute otitis media.


Solar retinopathy.

Solar retinopathy.


Subnormality in the seventies: priority in resources.


Preliminary assessment of the 1967 Abortion Act in practice.


Cold weather and myocardial infarction.

Cold weather and myocardial infarction.


Radiation-induced breast cancer.

Radiation-induced breast cancer.


Simplified peritoneal dialysis.

Simplified peritoneal dialysis.


Toxic reaction to Corynebacterium ulcerans.


Intrusion.

Intrusion.


Who benefits?

Who benefits?


Screening clinics.

Screening clinics.


Kwashi shakes.

Kwashi shakes.


Death penalty.

Death penalty.


Viraemia in rabies.

Viraemia in rabies.


Once a bad'n?

Once a bad'n?


Serum immunoelectrophoresis in patients with Ewing's sarcoma.


Recovery of resistance factors from a drug-free community.


Hospitals, press, and public.

Hospitals, press, and public.


Plasma-cell dyscrasia following prolonged stimulation of reticuloendothelial system.


Misdirected money-raising.

Misdirected money-raising.


Antitrypsin deficiency in lung disease.

Antitrypsin deficiency in lung disease.


Hospital staffing structure.

Hospital staffing structure.


Venous thromboembolism and blood-group.

Venous thromboembolism and blood-group.


Lipid disorders and heart-disease.

Lipid disorders and heart-disease.


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


5-Fluorouracil and radiotherapy for gastrointestinal cancer.


Analgesic abuse and tumours of renal pelvis.


Dangers of decimals.

Dangers of decimals.


Arm circumference in children.

Arm circumference in children.


The burned hand.

The burned hand.


Immune tolerance and pollen allergy.

Immune tolerance and pollen allergy.


Isoprenaline and practolol.

Isoprenaline and practolol.


Effect of nephrectomy on blood-transfusion requirements.


Varicella and cytosine arabinoside.

Varicella and cytosine arabinoside.


Toxicity of folic acid.

Toxicity of folic acid.


A sensitive test for folic-acid deficiency.


Mr. Crossman at a crossroads.

Mr. Crossman at a crossroads.


Brucellosis.

Brucellosis.


Reticuloendothelial blockage and A.L.S.

Reticuloendothelial blockage and A.L.S.


Intrathecal methotrexate.

Intrathecal methotrexate.


Isolated trigeminal neuropathy.

Isolated trigeminal neuropathy.


Typhoid carriage in pregnancy with infection of neonate.


War prevention and the doctor.

War prevention and the doctor.


Bone abnormalities and XYY syndrome.

Bone abnormalities and XYY syndrome.


Leucocyte interferon production in immunological deficiency diseases.


Consultant opinion.

Consultant opinion.


Assault in a mental hospital.

Assault in a mental hospital.


Douglas Hamilton MacLeod, M.S. Lond., F.R.C.P., F.R.C.S., F.R.C.O.G.


Morphological studies on horse kidney culture cells infected with cytopathic equine orphan (CEO) virus.


Behavior of antibody-producing cells and their related cells in equine infectious anemia.


Immunoglobulin determinants on the surface of mouse lymphoid cells.


Interpretation of beta globulin in metabolic profiles.


Hot, acidified rhodamine B and methylene blue; a differential stain dichromatic for hair follicular keratins, achromatic for epidermal keratin.


Neutral red as a lipid fluorochrome.

Neutral red as a lipid fluorochrome.


Specificity and sensitivity of insulin staining by aldehyde fuchsin, pseudoisocyanin and toluidine blue.


Transverse mounting of ribbons on groups of slides for comparing different stains in adjacent sections.


Vital staining by Fe and Mn salts for electron microscopy of plant tissue (Elodea).


A centrifugation technique for preparing medium-free resinous mounts of Feulgen-stained pollen tubes.


Effects of sunlight on stained sections mounted in various media.


The clinical value of assaying proteins in the cerebrospinal fluid. A comparative study in methods.


Behaviour growth and development course, first year medicine McGill University.


The integumentary mucous secretions of the earth worm Megascolex mauritii.


The nature and composition of the outer layers of the cuticle of Acanthosentis oligospinus n.sp. (Acanthocephala) from the fish Macrones gulio.


Pathomorphology of experimental influenza. I. Lungs.


A further contribution to the study of the contact region of Octopus synaptosomes.


Pathomorphology of experimental influenza. II. Liver.


Pathomorphology of experimental influenza. 3. Spleen.


Coagulation studies with linear copolymers of aliphatic hydrocarbons and maleic acid: new class of anticoagulants.


Natural F-actin. IV. Length distribution and its change studied by electron microscopy.


Nonenzymatic polymerization of fibrinogen by protamine sulfate. An electron microscope study.


Substrate-induced dissociation of lysozyme dimers.


Discrepancies between systemic anaphylaxis and the Schultz-Dale reaction.


Response of the sensitized heart to oxidized and reduced streptolysin O.


Fluorescence microscopy of the small intestines of rats and sheep, with reference to the presence of immunoglobulin in globule leucocytes.


Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung.


Ultrastructural localization of acid mucosubstance and antimonate-precipitable cation in human and rabbit platelets and megakaryocytes.


A technique for the radioautography of germ cells in whole mounts of seminiferous tubules.


Distribution of acid and alkaline phosphatase activity in undemineralized sections of the rat tibial diaphysis.


Isolation of plasma lipoproteins by zonal ultracentrifugation in the B14 and B15 titanium rotors. Lipoproteins were isolated from plasma of man, dog, rabbit, rat, and chicken by ultracentrifugation in continuous density gradients using the B14 titanium and B15 titanium zonal rotors. Both the VLDL and the LDL of human plasma were separated easily from the HDL and from the other more plentiful plasma proteins by centrifugation for only 1 or 2 hr in the B14 or B15 rotor, respectively. Satisfactory separation of the HDL from the more dense plasma proteins was not achieved with these rotors. The human LDL achieved isopycnic equilibrium (d 1.04) on prolonged periods (> 24 hr) of centrifugation in a sucrose-KBr density gradient. The pattern of distribution of cholesterol and phospholipid throughout the density gradient coincided with the pattern of distribution of the lipoprotein-protein measured spectrophotometrically or chemically. The concentration of cholesterol and phospholipid in the lipoproteins isolated by zonal ultracentrifugation agreed with analyses reported for lipoproteins isolated by sequential centrifugation in solutions of increasing density. The lipoproteins isolated by zonal ultracentrifugation were characterized further by their electrophoretic behavior. The fractions which were identified as the LDL (d 1.04-1.05) from all species migrated on paper as a beta-globulin; the LDL from plasma of dogs contained an additional component which has been designated as an alpha(2)-globulin. The fractions which were identified as the HDL from all species migrated as an alpha(1)-globulin. Reaction of human LDL with either rabbit antihuman beta-lipoprotein or rabbit antihuman serum resulted in a single immunodiffusion band. The S(f, 1.063) of the human LDL was calculated to be 6.0. When plasma from humans or rabbits was centrifuged in the B15 rotor, the HDL was not visible as a distinct peak and was not separable from the bulk of the more dense plasma proteins; when plasma from dogs or chickens was centrifuged under identical conditions, the HDL was clearly detectable. Even though the mean density of the HDL from dogs or chickens was not different from that of man or rabbits, the visibility of this lipoprotein in dogs and chickens was probably due to its high concentration in the plasma of these species. When plasma from the rat was centrifuged under similar conditions, the HDL was also clearly in evidence. Although rat plasma contained a relatively small concentration of HDL, the lipoprotein had a lower mean density than did the HDL of the other species and was therefore more easily separable from the dense plasma proteins. The procedure of zonal ultracentrifugation for the isolation of lipoproteins by flotation is simultaneously preparative and analytical and should find useful application in the investigation of the soluble lipoproteins from plasma and tissues.


Submicroscopic distribution of ruthenium red in human glioblastoma multiforme.


Pancreatic insufficiency and neutropenia with associated immunoglobulin deficit.


Immunologic studies in patients with malignant melanoma in Uganda.


Microscopic root canal technique.

Microscopic root canal technique.


Studies on histamine release from leukocytes of penicillin-sensitive individuals.


Studies on adult metachromatic leukodystrophy. 1. Clinical, morphological and histochemical observations in two cases.


Sensitization to carrier antigens following delayed reactions to the hapten.


Histological and histochemical studies of experimentally-induced degeneration and regeneration in normal and dystrophic mouse muscle.


Studies on the ability of the soluble proteins from skin, painted in vivo with DNFB, to cause contact sensitivity in the guinea pig.


2-(4-imidazolyl)cyclopropylamine.


Operating room forum: O.R. nurses: handle with special care.


Gamma globulin in urinary protein in  chronic pyelonephritis.


Immunofluorescent examination of biopsies from long-term renal allografts.


Deep-freeze preservation of normal and pathologic human semen.


State of the ejaculatory ducts, deferent duct ampullae, seminal vesicles and posterior urethra after various operations for benign prostatic hyperplasia. A vasovesiculographic and urethroscopic study.


A case of prostate hyperplasia.

A case of prostate hyperplasia.


Transitional cell epithelioma of the bladder: correlation of cytologic and histologic diagnosis.


Observations on the epidemiology, diagnosis and treatment of demodicosis in dogs.


On the Z-substance of striated muscle.

On the Z-substance of striated muscle.


On step-like plaque-growth.

On step-like plaque-growth.


Studies on the effects of proteins on phosphate uptake by sand dollar embryos.


Regulation of glutamate pyruvate transaminase in the amphibian (Rana hexadactyla) kidney and liver homogenates.


Kinins and kininogen in endotoxin shock.


The larval ring gland of Drosophila melanogaster: a comparison of Ebony and Oregon strains by use of a qualitative protein stain.


Palliative treatment of metastasized breast cancer with 5-FU in slow intravenous infusion.


Correlation between protein changes and blood leucocytes in experimental trichinellosis.


Neonatal splenectomy in rats.

Neonatal splenectomy in rats.


Classification of ventricular extrasystoles according to form.


Thyroid function in protein-depleted rats.


Effect of antilymphocyte antibody on humoral antibody formation.


In vitro differentiation of a mouse neuroblastoma. Mouse tumor C1300 has been established in tissue culture. The cells have a round cell morphology in both the subcutaneous tumor and in suspension culture. However, when given a surface on which to attach, they send out processes up to 3 mm in length and assume the morphology of mature neurons. The attached cells are stained by the Bodian silver procedure for neurons, whereas the cells grown in suspension are not. Electron microscopy reveals that the attached cells contain neurofilaments, neurotubules, and densecore vesicles indicative of nerve fibers. Both free-floating and attached cells have tyrosine hydroxylase activity characteristic of sympathetic nervous tissue. Apparently cell attachment can induce morphological differentiation from an anaplastic round cell to a cell which has many properties of a mature neuron.


Staining microfilariae for structures other than nuclei.


Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate. A sensitive and specific radioimmunoassay for adenosine 3',5'-cyclic phosphate (cyclic AMP) has been developed which allows measurement of the nucleotide in extracts of 5-10 mg of tissue. The radioimmunoassay is sufficiently specific for cyclic AMP to eliminate the need for prior chromatographic separation of the cyclic nucleotide from other tissue nucleotides. The radioimmunoassay system is based upon competition of cyclic AMP with a labeled cyclic AMP derivative of high specific activity for binding sites on an antibody specific for the cyclic nucleotide. Antibody to cyclic AMP was obtained by immunizing rabbits with an antigen prepared by conjugating succinyl cyclic AMP with human serum albumin. A high specific activity derivative of cyclic AMP was prepared by synthesizing succinyl cyclic AMP tyrosine methyl ester (SCAMP-TME) and iodinating the phenolic hydroxyl group of the tyrosine moiety with (125)I. Free and antibody-bound (125)I-SCAMP-TME were separated by precipitation of the antibody-bound fraction with a second antibody (goat anti-rabbit gamma globulin). Displacement of (125)I-SCAMP-TME by unlabeled cyclic AMP when plotted as a semilogarithmic function was linear over a concentration range of 2-100 picomoles. The specificity of the antibody was tested against structurally related nucleotides, nucleosides, and purine bases. All had less than 0.005 per cent of the potency of cyclic AMP in inhibiting (125)I-SCAMP-TME binding. The marked differences in affinity of the various cyclic nucleotides to cyclic AMP antibody would suggest that antibodies can be developed for each of the cyclic nucleotides by the principles used in this work.


Antihuman lymphoblast globulin.

Antihuman lymphoblast globulin.


The lympho-epithelial organs of Homo sapiens revisited.


Quantitative assay of a single proteolytic enzyme in a crude mixture of bacterial proteinases.


Enzymoserological separation of bacterial proteinases.


Increase in sensitivity of the rhodamine B method for keratinization by the use of fluorescent light.


Abnormalities of the costochondral junction in cases of perinatal death, with special reference to hyaline membrane disease.


Growth of Rous hamster sarcoma on the chorio-allantoic membrane.


Further studies on the interaction in vitro between mammalian Rous sarcoma cells and chicken fibroblasts.


Cushion-like intimal lesions and platelet aggregates in intramyocardial arteries of man.


Changes in the concentration of lymphocytes in the intestinal epithelium of hibernating ground squirrels (Citellus tridecemlineatus).


Estrogenic regulation of uterine pyruvate kinase.


Postexercise hyperhistaminemia, dermographia, and wheezing.


Rheumatoid arthritis with positive LE clot test in children.


Contribution to steady potential shifts of slow depolarization in cells presumed to be glia.


Units during habituation, discrimination learning, and extinction.


Slow potential changes in cat brain during classical appetitive conditioning of jaw movements using two levels of reward.


Auditory averaged evoked potentials in man during selective binaural listening.


Somato-sensory response to mechanical stimulation as recorded in the human EEG.


Eye movement artifact in the CNV.

Eye movement artifact in the CNV.


EEG alpha activity influenced by visual input and not by eye position.


Effects of binocular fusion and binocular rivalry on cortically evoked potentials.


The effects of alcohol on visual and somato-sensory evoked responses.


Solid miniature silver-silver chloride electrodes for chronic implantation.


Electrode jelly and skin reaction over several days. Comparison of two electrode jellies.


An EEG study during angiocardiographic procedures in children.


EEG studies in children with leukaemia.

EEG studies in children with leukaemia.


A correlation between evoked potentials and point-to-point interocular suppression.


The contingent negative variation in cases of known brain lesions.


Electrophysiological changes induced by pontine split in cats.


Preferred and non-preferred EEG frequency components in post-central areas; observations with particular reference to the 3-7 c-sec range.


Experimental investigation on the epileptogenesis of kittens.


Experimental hypothyroidism and body temperatures.


Habituation of the orienting reflex during sleep.


The development and spread of focal seizures in the newborn monkey.


Overdose of tricyclic antidepressants and REM sleep rebound.


EEG and cortical structure.

EEG and cortical structure.


A test for distinguishing secondary from primary bilateral synchrony in epileptic subjects.


Effects of electrographic seizure discharges on conditioned avoidance responses in man.


Periodic myoclonic epilepsy in the kitten: an experimental study on the reactivity of the immature brain.


Differential diagnosis of organic epileptic foci and functional epilepsy of maturation by means of a vertical montage.


Epileptic seizures in chronic alcoholics.


On-line analysis of EEG with a small computer.


Considerations on the automatic analysis of EEG data.


Sleep-like patterns and abnormal arousal reactions in brain stem lesions.


Evoked response audiometry (film).

Evoked response audiometry (film).


Language-evoked response audiometry in aphasia.


The basic rhythm in man is not occipital in origin.


The influence of motor activity on the alpha rhythm.


Bilateral depression in photo-evoked response as a late effect of unilateral visual cortex X-irradiation.


Contribution to the methodology of evoked potentials recording during sterotactic surgery for pain.


Visual evoked potentials in epileptic patients.


Electroencephalographic studies before and after head injuries.


Recognition of the traumatic origin of EEG abnormalities.


Seizures in brain tumors.

Seizures in brain tumors.


EEG patterns in a case of subacute sclerosing leucoencephalitis after intravenous administration of two benzodiazepine derivates.


EEG control of a cortisone psychosis.

EEG control of a cortisone psychosis.


EEG changes in combined sclerosis.

EEG changes in combined sclerosis.


Health effects of air pollution. Report on a symposium.


Juvenile chronic lymphocytic thyroiditis: clinical, laboratory and histological correlations.


Thyroxine biosynthesis in human goitrous cretinism.


Two-phase chemotherapy of pulmonary tuberculosis.


Suppressibility of thyroid function during treatment with antithyroid drugs in Grave's disease.


Induction of hepatic delta-amino-levulinic acid synthetase by oral contraceptive steroids.


Histological methods for peripheral nerves. I.


An iron-containing artefact in tissue sections.


Picric acid--Schiff methylene blue technique to demonstrate nucleic acids in formalin-fixed paraffin sections.


Studies on the accessory factor for Toxoplasma dye test. Guinea pig serum as a source of the accessory factor.


Increased sickling of parasitised erythrocytes as mechanism of resistance against malaria in the sickle-cell trait.


Plasma-zinc in health and disease.

Plasma-zinc in health and disease.


Echoviruses, carditis, and acute pleurodynia.


Plasma-corticosteroid levels in accidental hypothermia.


Pituitary-adrenal response to surgical stress in patients receiving corticotrophin treatment.


Suction amnioscopy for fetal blood-sampling.


Use of test strips with colour meter to measure blood-glucose.


Renal-clip hypertension in rabbits immunised against angiotensin II.


A random-zero sphygmomanometer.

A random-zero sphygmomanometer.


Fetal hibernation?

Fetal hibernation?


Green and white.

Green and white.


Mr. Irvine's bill.

Mr. Irvine's bill.


Angiotensin and renovascular hypertension.


Intensive care of the newborn.

Intensive care of the newborn.


Sudden unexpected death.

Sudden unexpected death.


Solitary ulcer of the rectum.

Solitary ulcer of the rectum.


Allergic alveolitis in malt workers.

Allergic alveolitis in malt workers.


Complaints in hospitals.

Complaints in hospitals.


A scheme for integration.

A scheme for integration.


Structure of the National Health Service. New green-paper.


L-dopa in depressed patients.

L-dopa in depressed patients.


Measurement of behavioural changes in patients on L-dopa.


Treatment of drug-induced dyskinesias.

Treatment of drug-induced dyskinesias.


Professor Miller on psychiatry.

Professor Miller on psychiatry.


Vasectomy and A.I.H.

Vasectomy and A.I.H.


Serum-lactic-dehydrogenase activity and intravascular haemolysis.


Separation of serum-alkaline phosphatase.


Leucocyte G.-6-P.D. levels and bactericidal activity.


Poisoning with multiple antidepressant drugs.


Treatment of carbon-monoxide poisoning.

Treatment of carbon-monoxide poisoning.


Prostaglandins.

Prostaglandins.


University upheaval.

University upheaval.


Mycoplasma pneumoniae polyradiculitis.

Mycoplasma pneumoniae polyradiculitis.


Origins of war.

Origins of war.


Pattern of development and loss of bone with age.


Toxicity of folic acid.

Toxicity of folic acid.


Assessing the sputum.

Assessing the sputum.


Appeal to doctors.

Appeal to doctors.


Safety containers for medicines.

Safety containers for medicines.


Future of postgraduate medical education.


The Ladies Guild of the Royal Medical Benevolent Fund.


Measurement of G.F.R. in renal disease.

Measurement of G.F.R. in renal disease.


Unusual behavior of a C.S.F. protein.

Unusual behavior of a C.S.F. protein.


Propranolol in acute porphyria.

Propranolol in acute porphyria.


Aspirin and blood fibrinolysis.

Aspirin and blood fibrinolysis.


Water additives.

Water additives.


Detection of bacteriuria.

Detection of bacteriuria.


Epilepsy and G.-6-P.D. deficiency.

Epilepsy and G.-6-P.D. deficiency.


Effect of A.L.S. and prednisolone on the electrophoretic mobility of lymphocytes.


Suicide with plastic bag and ethyl ether.


Stimulation of Brunner's glands.

Stimulation of Brunner's glands.


Bilateral absence of testes.

Bilateral absence of testes.


Rarity of Ewing's sarcoma among U.S. Negro children.


Abortion capital.

Abortion capital.


Oral contraceptives and serum-proteins.

Oral contraceptives and serum-proteins.


Bovine leukosis and human cancer.

Bovine leukosis and human cancer.


Case of juvenile chronic myeloid leukaemia.


Syphilis and hepatic cirrhosis.

Syphilis and hepatic cirrhosis.


IgA and autoimmunity.

IgA and autoimmunity.


Cryoglobulinaemia and nephritis.

Cryoglobulinaemia and nephritis.


Albert Victor Neale, M.D. Birm., F.R.C.P., D.P.H.


The radiology of small bowel lesions.

The radiology of small bowel lesions.


The fate of some foreign proteins in the cat.


A turbidity test for the estimation of immune globulin levels in neonatal calf serum.


Polyacrylamide disc electrophoresis of cerebrospinal fluid and cerebral cyst fluids.


Brain tumors.

Brain tumors.


Immunochemistry of staphylococcal nuclease. II. Inhibition and binding studies with sequence fragments.


Salt effects on antigen-antibody kinetics.


The plasma factor and transport of indoleamino acids.


Ultrastructure of the superior cervical ganglion fixed with zinc iodide and osmium tetroxide.


Chlorambucil treatment of patients with cold agglutinin syndrome.


Cytoplasmic basophilia of Purkinje cells of the rabbit.


Stellate cells and their synapses on Purkinje cells in the cerebellum of the frog.


Tape-slide programmes in medical education at the university of Newcastle upon Tyne.


Teaching aids for the demonstration of astigmatism and astigmatic vision.


The biologic activities of guinea pig antibodies. I. Separation of gamma1 and gamma2 immunoglobulins and their participation in allergic reactions of the immediate type.


The biologic activities of guinea pig antibodies. II. Modes of complement interaction with gamma 1 and gamma 2-immunoglobulins.


The capacity of human immunoglobulin E to mediate the release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung.


The measurement of immunoglobulin associated with human peripheral lymphocytes.


Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey.


Synthesis of secretory IgA in the rabbit. II. Production of alpha, light and T chains by in vitro cultures of mammary tissue.


Synthesis of secretory IgA in the rabbit. 3. Interaction of colostral IgA fragments with T chain.


Correlation between ocular inflammation and antibody production. I. Serum antibody response following intravitreal immunization with protein antigens.


Correlation between ocular inflammation and antibody production. II. Hemolytic plaque formation by cells of the uveal tract.


Antigenic specificity of gamma A polymers.


A new serum factor in normal rabbits. V. Induction in neonatal rabbits.


Immunoglobulin classes of antibody-forming cells in mice. II. Class restriction of plaque-forming cells demonstrated by replica plating.


Immunoglobulin classes of antibody-forming cells in mice. I. Localized hemolysis-in-agar plaque-forming cells belonging to five immunoglobulin classes.


Isoelectric separation of mouse immunoglobulins.


Evidence for conformational unfolding of immunoglobulin heavy chains in propionic and acetic acids.


3',5' cyclic adenosine monophosphate in depression and mania.


Ophthalmic Graves' disease. Diagnosis and pathogenesis.


Female sterilisation by tubal electrocoagulation under laparoscopic control.


Clonal origin for individual Burkitt tumours.


Muscle water and electrolytes in pyloric stenosis.


Aortic-valve disease in Turner's syndrome.


Relation between bone mass and muscle weight.


Prevention of venous thrombosis.

Prevention of venous thrombosis.


Pressure on G.M.C.

Pressure on G.M.C.


Fetoproteins.

Fetoproteins. After a brief summary of the discovery of fetoproteins, the pathological implications of them are discussed.  An analysis of the antigenic structure of hepatomas induced in mice led to the discovery of this protein's elaboration by the hepatomas.  In mice, fragments of the tumor could be maintained in vitro and these synthesized fetoprotein; fetoprotein production could also be maintained after grafting of hepatomas.  However, the mouse model is less amenable than the rat because only 30% of mouse vs. 80% of rat hepatomas synthesize fetoprtein.  3 fetoproteins have been studied in the rat model in relation to hepatomas.  2 of the 3 are also found in adult humans (lipoprotein esterase and alpha 2 glycoprotein) and arise in response to both neoplastic and nonneoplastic conditions.  The 3rd, globulin antigen L.A. (liquid amniotique) is regularly and specifically associated with primary and transplanted hepatomas.  In humans, the association between fetoproteins and hepatocellular carcinoma has been studied since 1965; the commonly cited figure of association is 60%, though important geographical variations may occur.  Benign liver tumors, bile duct tumors, and 2ndary liver tumors do not secrete fetoproteins, and the only nonhepatic neoplasm which has been shown to do so is testicular teratoblastoma, with which fetoproteins are associated in about 10% of cases.  2 recent observations on fetoproteins concern laboratory animals.  Hepatomas developed in monkeys given N-nitrosodiethylamine, and most of the tumors made fetoprotein.  Also, positive fetoprotein tests were found in 5/10 pyridoxine-deficient baboons.


The recurrent laryngeal nerve at thyroidectomy.


Antiviral action of rifampicin.

Antiviral action of rifampicin.


Neurologists.

Neurologists.


Single-cell origin for Burkitt's tumour?


Death of the professor of medicine.

Death of the professor of medicine.


Iatrogenic leg dermatitis.

Iatrogenic leg dermatitis.


Posture of the unconscious patient.

Posture of the unconscious patient.


Professional reputation.

Professional reputation.


Sex and gender.

Sex and gender.


Integrated system for the purchase, distribution, and use of drugs in hospital.


The alpha 1-fetoprotein test in hepatocellular carcinoma.


Herpes encephalitis treated with intravenous idoxuridine.


Coeliac infertility-folic-acid therapy.

Coeliac infertility-folic-acid therapy.


Subluxation of the sacroiliac joint.

Subluxation of the sacroiliac joint.


Coagulation defect due to anticonvulsant drug treatment in pregnancy.


Long-term anticoagulants.

Long-term anticoagulants.


Protein-binding of drugs.

Protein-binding of drugs.


Eosinophilia in childhood asthma.

Eosinophilia in childhood asthma.


Serum immunoelectrophoresis in patients with Ewing's sarcoma.


Multiple sclerosis in Israel.

Multiple sclerosis in Israel.


Care of the mentally subnormal.

Care of the mentally subnormal.


Psychiatric unit in the district general hospital.


Resuscitation ambulances.

Resuscitation ambulances.


Lithium toxicity.

Lithium toxicity.


Salts supplements with lithium.

Salts supplements with lithium.


Rectal perforation by thermometer.

Rectal perforation by thermometer.


Skin-grafting leg ulcers.

Skin-grafting leg ulcers.


Rubella vaccines.

Rubella vaccines.


Arm circumference in school children.

Arm circumference in school children.


Femoral saphenous cannula.

Femoral saphenous cannula.


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


Diagnosis of colour-vision defects in very young children.


Travellers' diarrhoea.

Travellers' diarrhoea.


Origins of war.

Origins of war.


Lymphocyte transformation in the Guillain-Barré syndrome.


Management of convulsions.

Management of convulsions.


Valium and epilepsy.

Valium and epilepsy.


Treatment of essential hyperlipidaemia.

Treatment of essential hyperlipidaemia.


Au antigen in at-risk patients.

Au antigen in at-risk patients.


Genetics of schizophrenia.

Genetics of schizophrenia.


Inhibition of iron absorption by pancreatic extracts.


Creatinine clearance in patients with proteinuria.


Prostaglandins.

Prostaglandins.


Treatment of arrhythmias with verapamil.


Dermatoglyphics and leukaemia.

Dermatoglyphics and leukaemia.


Care of the mentally subnormal.

Care of the mentally subnormal.


Samuel Hall Wass.

Samuel Hall Wass.


Everard Harry George Williams.

Everard Harry George Williams.


William Goldie.

William Goldie.


Patterns of recurrent disease in breast cancer.


Hospital food as a possible source of Escherichia coli in patients.


Late metabolic sequelae of vagotomy and gastroenterostomy.


Clinical evaluation of internal mammary-artery implantation.


Infection from intravenous catheters.

Infection from intravenous catheters.


Diffuse pulmonary disease with transfer defect occurring with coeliac disease.


Double-blind clinical trial of bromhexine as a mucolytic drug in chronic bronchitis.


Safety devices for anaesthetic connections.


Nature of concentrating defect in sickle-cell nephropathy. Microradioangiographic studies.


New ways with digoxin.

New ways with digoxin.


Visible proof.

Visible proof.


New deal for the mentally handicapped.

New deal for the mentally handicapped.


Immunoglobulin deficiency and pernicious anaemia.


Hazards for pregnant nurses.

Hazards for pregnant nurses.


Sea-blue histiocytes.

Sea-blue histiocytes.


Roots of aggression.

Roots of aggression.


Application of triage to the provision of medical care in developing countries.


Amantadine in Parkinson's disease.

Amantadine in Parkinson's disease.


Winter and heart-disease.

Winter and heart-disease.


Appeal to doctors.

Appeal to doctors.


Dangers of decimals.

Dangers of decimals.


Distance marker rings on endotracheal tubes.


Detection of bacteriuria.

Detection of bacteriuria.


Natural gas, unnatural causes.

Natural gas, unnatural causes.


"Sixty plus".

"Sixty plus".


Mental-hospital admissions and aircarft noise.


Mental-hospital admissions and aircraft noise.


Bacteria in suction machines.

Bacteria in suction machines.


Fetal hibernation.

Fetal hibernation.


Treatment of carbon-monoxide poisoning.

Treatment of carbon-monoxide poisoning.


John, 17 months.

John, 17 months.


Chromosome and D.N.A. abnormalities in ovarian cystadenomas.


Combined surgery and chemotherapy for carcinoma of the bronchus.


The Hodgkin maze.

The Hodgkin maze.


Insulin and the heart.

Insulin and the heart.


Athletic pseudonephritis in relation to rate of exercise.


Diet and atherosclerosis.

Diet and atherosclerosis.


Polyunsaturated fatty acids and myocardial infarction.


Hereditary haemorrhagic telangiectasia: aggravation by oral contraceptives?


Mitochondrial aspartate transaminase.

Mitochondrial aspartate transaminase.


Oscillation during the immune response.

Oscillation during the immune response.


Steroid therapy for haemophilia.

Steroid therapy for haemophilia.


Simian virus reference centre.

Simian virus reference centre.


Marburg virus.

Marburg virus.


Francis Peyton Rous, M.D. Johns Hopkins.


Edward Rowland Alworth Merewether, C.B., C.B.E., M.D. Durh., F.R.C.P., D.I.H., F.R.S.E.


Leonard Haydn Howells, M.D. Lond., B.Sc. Wales, F.R.C.P.


The loss of thyrotrophin in the urine of nephrotic rats as a model to study the pathogenesis of endocrine disorders in hypoproteinemia.


Properties of protective malarial antibody.


Eight types of bisalbuminaemia.

Eight types of bisalbuminaemia.


Hemostatic adenomectomy.

Hemostatic adenomectomy.


Quality control in special histologic staining.


The termination of optic fibres in the lateral geniculate nucleus of some primates.


Inhibition of allergic reactions in man and other species by cromoglycate.


The National Library of Medicine: how it serves the dentist.


Cutaneous streptothricosis in a bull.

Cutaneous streptothricosis in a bull.


Effect of serum from irradiated rats on gastrointestinal function.


Lead effects on corn mitochondrial respiration. Oxidation of exogenous nicotinamide-adenine dinucleotide and succinate by corn mitochondria was measured as a function of lead chloride concentration. Lead chloride (50 to 62 micromoles per liter) stimulated oxidation of exogenous reduced nicotinamide-adenine dinucleotide by 174 to 640 percent depending on the reaction mediums, whereas lead chloride (12.5 micromoles per liter) inhibited succinate oxidation by more than 80 percent. When inorganic phosphate was included in reaction mediums the subsequent addition of lead was without effect due to the low solubility of lead phosphate. If addition of lead was followed by addition of phosphate the inhibition of succinate oxidation by lead was released, but there was no reduction in the stimulation of oxidation of reduced nicotinamide-adenine dinucleotide by lead. The effects of lead on plant growth might be accentuated under conditions of phosphate deficiency.


Radioimmunoassays employing immunosorbents.


Immunofluorescent studies of the replication of rat virus (HER strain) in tissue culture.


Efficiency testing of passive immunization against Venezuelan equine encephalomyelitis in mice.


Diagnosis of congenital cardiac defects with use of a fiberoptic catheter-pressure-cinetrace system.


Cancer, emotions, and nurses.

Cancer, emotions, and nurses.


An allergic circulatory collapse following the administration of muscle relaxants.


Determination of psychotropic drugs in body fluids.


Acrylamide gel electrophoresis of the S-sulfo derivatives of fibrinogen.


Esophageal carcinoma: palliation by indwelling tubes.


The capillary in the human vestibular labyrinth. A histochemical staining technique.


Skin appendage tumors.

Skin appendage tumors.


Immunofluorescent staining of Salmonella species with flagellar sera. Salmonellae stained with flagellar sera by either the direct or indirect fluorescent-antibody technique fluoresced at the cell surface. Investigations showed that fimbriae, flagellar material, and capsule antigens were not the participating antigens in this reaction. Cell surface staining was inhibited by mannose but was unaffected by glucose, galactose, lactose, maltose, and sucrose. Specific absorption of the flagellar sera by intact cells and purified somatic antigen showed that O antigens were the site of the surface staining. The advantages of using flagellar sera in fluorescent-antibody screening of materials for the presence of salmonellae are discussed.


Electrophoretic separation of multiple bands with beta-glucuronidase activity in human sera.


Exposure of garage and service station operatives to carbon monoxide: a survey based on carboxyhemoglobin levels.


Degradation of benzene hexachloride by a soil bacterium.


Mechanisms of histamine release by compound 48-80. 1. Rat and guinea-pig lung tissues were incubated for 20 min at 37 degrees C in Krebs-Ringer phosphate buffer at pH 7.4, or in Tyrode-Tris buffer at pH 8.2, and the release of histamine produced by adding different concentrations of compound 48/80 to the incubation medium was determined.2. At pH 7.4, increasing concentrations of 48/80 increased the release of histamine from the rat lung, with a tendency towards a maximum. No release of histamine from guinea-pig lung was observed at this pH. At pH 8.2, histamine release occurred both from rat and guinea-pig lung, and was proportional to the logarithm of the concentration of compound 48/80.3. Histamine release from rat lung by 20 mug/ml. of 48/80 decreased when the pH was raised from 7.4 to 8.2; but the release caused by 1 mg/ml. of 48/80 increased both in rat and guinea-pig lung as the pH was raised.4. 2-4-Dinitrophenol (DNP) inhibited the release of histamine from rat lung by a concentration of 20 mug/ml. of 48/80; the inhibition was prevented by glucose. DNP did not affect histamine release from rat or guinea-pig lung by a concentration of 1 mg/ml. of 48/80 and enhanced the release when the pH was raised from 7.4 to 8.2.5. 1 mg/ml. of 48/80 did not inhibit the enhanced oxygen consumption produced by DNP in the isolated rat diaphragm.6. Iodoacetic acid (IAA) or a Ca/Mg-free medium inhibited the release of histamine by 20 mug/ml. of 48/80 from rat lung but not the release produced by 1 mg/ml. in either rat or guinea-pig lung.7. The degranulation of rat mesentery mast cells caused by 20 mug/ml. of compound 48/80 was inhibited by DNP. The degranulation evoked by 1 mg/ml. of 48/80 was also sensitive to this inhibitor; in this instance, however, the metachromatic staining reaction of the mesentery mast cells was greatly diminished.8. It is concluded that two processes of histamine release by compound 48/80 occur in rat lung. One, dependent on cell metabolism, involves, mast cell granule secretion. The other, independent of cell metabolism, seems to consist of a simple exchange reaction between histamine and compound 48/80, and this is the only one occurring in guinea-pig lung.


Exceptions to bilateral symmetry in the epithalamus of lower vertebrates.


The location of chemical components on ultrathin sections of Bacillus cereus embedded in glycol methacrylate.


DNA activity in the endometrial stroma of the cycling rat as measured by Feulgen staining and by [3H]thymidine incorporation.


The relationship between group A and group C meningococcal polysaccharides and serum opsonins in man. The interaction in vitro between human granulocytes and meningococci in the presence of sera from volunteers immunized by Gotschlich et al. with purified group A and group C meningococcal polysaccharides was studied. Phagocytosis of meningococci did not occur in the presence of preimmunization sera. In all volunteers tested, group-specific opsonins were detected in groups A and C polysaccharide antisera. Opsonic activity appeared within 1 wk after immunization and persisted for at least 14 months. Titers of opsonic activity ranged from 1:20 to 1:320; highest titers were noted in 2-4 wk antisera. Meningococcal opsonins were detected in both 19S and 7S immunoglobulins. Opsonic activity in low-titer antisera depended on heat-labile factors present in both normal and immune sera, whereas phagocytosis was observed in the presence of heat-inactivated high-titer antisera. Phagocytosis of group A meningococci in the presence of certain group A polysaccharide antisera was inhibited by N-acetyl mannosamine, but not by mannose, mannosamine, N-acetyl glucosamine, N-acetyl galactosamine, or N-acetyl neuraminic acid. Absorption studies with sera from patients with natural meningococcal infections revealed that these polysaccharides are the major antiphagocytic determinants for group A and group C meningococci. These studies are consistent with previous reports suggesting that immunization with group A and group C polysaccharides may well provide group-specific protection against meningococcal infections.


Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits. MPC-11 myeloma tumor cells were adapted to growth in continuous culture. The cultured cells resembled the parent tumor in that they produced the fully assembled gamma globulin molecules as well as six unassembled molecules. Although cultured and tumor cells synthesized excess light chains, the molar ratio of light (L) to heavy (H) chains was approximately 1.7:1 in the culture, and 3.5:1 in the tumor. The cultured cells also produced fewer half molecules and free light chains than the parent tumor. Peptide column analysis did not reveal differences in the primary structure of the H chains derived from the parent tumor and the culture. The L chains may have differed by a minor peptide. As much as 20% of the newly labeled cytoplasmic proteins and almost 100% of the proteins secreted by the cultured myeloma cells could be precipitated by specific antiserum. The immune precipitates contained seven different gamma globulin molecules, six of which were characterized according to their molecular size and H and L chain content as fully assembled molecules (H(2)L(2)), heavy chain dimers (H(2)), half molecules (HL), H, light chain dimers (L(2)), and L chains. All gamma globulin subunits as well as the complete H(2)L(2) molecule were produced and secreted by splenic clones of the parent MPC-11 tumor, and agar clones of the cultured cells. This indicates that the various gamma globulin subunits were produced by the same cell and did not reflect cellular heterogeneity with respect to gamma globulin synthesis.


Sore throat therapy.

Sore throat therapy.


Sodium levothyroxine (Synthroid R) intoxication in a child.


Technical aids in surgery.

Technical aids in surgery.


Short thoughts on long hair.

Short thoughts on long hair.


Responses of skeletal muscle pH to injury: a new technique for determination of tissue viability.


Changes over time in blood basophil counts of x-irradiated rabbits.


A study of lymph node polysomes and proteins during antibody production.


Palliative radiation therapy in patients with cancer of the colon and rectum.


Delayed intestinal obstruction following treatment for cancer.


Antibody binding of thyroxine in the primate subjected to hetero- and isoimmunization against components of the thyroid gland.


Goitrogenic effect of walnut and its action on thyroxine excretion.


Relationships between the effects of iodide, methimazole and thyrotropin on the intermediary metabolism of bovine thyroid slices.


A serum fraction with "sulfation factor activity" stimulates in vitro incorporation of leucine and sulfate into protein-polysaccharide complexes, uridine into RNA, and thymidine into DNA of costal cartilage from hypophysectomized rats.


Influence of diethylstilbestrol on the renin-angiotensin system of male rats.


Parameters of thyroid function in serum of 16 selected vertebrate species: a study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins.


Influence of the pituitary gland on sodium conservation, plasma renin and renin substrate concentrations in the rat.


Quantitative interference microscopy of polytene chromosomes. II. Cytochemical studies via ultramicrospectrophotometry.


Mucopolysaccharide histochemistry of Musca domestica. I. A report on the occurrence of a new type of KOH-labile alcianophilia.


Secretory granules and immunoglobulins in epithelial cells of the large intestine.


Subcellular distribution of immunoglobulin in the large intestine of monkey and sheep.


Columnar cells with secretory granules in the large intestine of the macaque (Cynamolgus irus).


Immunofluorescent localization of the LH cell of the human adenohypophysis.


Antidiuretic effect and complications of chlorpropamide therapy in diabetes insipidus.


Endemic cretinism in the Andean region of Ecuador.


Effect of estrogen on the metabolism of metyrapone and release of ACTH.


New technique for assessing acrosomal characteristics of spermatozoa.


Disaccharidase deficiency in children with immunologic deficits.


Tropical sprue in children.

Tropical sprue in children.


Factors affecting protein iodination using chloramine T and the assessment of homogeneity of serum 131-I-proteins.


Rabbit milk transferrin: physiological studies and comparison with serum transferrin.


Serum agglutinators reacting with pepsin treated gamma-globulin. I. "Naturally occurring" reactants in the serum of subhuman primates (final report). Rep No 815.


Tumors and serum glycoproteins. The 'symbodies'.


Success and failure in present chemotherapy and the implications of asparaginase.


Oxidation of reduced nicotinamide adenine dinucleotide by Mycobacterium phlei.


Recognition of Anaplasma marginale Theiler in Dermacentor andersoni Stiles (=D. venustus Marx) by the fluorescent antibody method. I. Smears of nymphal organs.


Tryptophanless death in Bacillus subtilis. A decline in colony-forming ability is observed in actively growing cultures of a tryptophan arginine auxotroph of Bacillus subtilis after removal of tryptophan (tryptophanless death). This phenomenon can be prevented by simultaneous starvation of the other required amino acid or by chloramphenicol administered in bacteriostatic concentration but not by actinomycin. Addition of tryptophan analogues not only prevents the death but also allows recovery of the cells that have lost the ability to form colonies on solid media. The term tryptophanless death is therefore inappropriate. Chloramphenicol but not actinomycin inhibits the recovery brought about by tryptophan analogues.


Tinctorial and morphologic properties distinguishing actinomycosis and nocardiosis.


Transitory demineralization of the femoral head.


Ultrastructure of the eosinophil granule-internum; the problem of reversed relative density.


Quantitative investigations on the effect of pentamethylenetetrazol on the supraoptic neurones in rabbit.


Histamine shock and fracture healing in rats, with special reference to the mast cell count in the periosteal callus.


Termination of the olivocerebellar system in the cat.


Antibody to lactate dehydrogenase. IV. Enzyme-inhibiting and inhibition-interfering components.


A clinical trial designed to test the relative value of two simple methods of reducing the risk of venous stasis in the lower limbs during surgical operations, the danger of thrombosis, and a subsequent pulmonary embolus, with a survey of the problem.


Contraception with chlormadinone acetate in woman with previous contraceptive jaundice. The oral contraceptive chlormadinone acetate has been given for eight months to a woman who had developed jaundice during four pregnancies, and twice while taking a combined contraceptive pill. No side-effects or changes in liver function were observed. This is further evidence that progestogens used for contraception, and in particular those derived from hydroxyprogesterone, are less hepatotoxic than the oestrogenic components.


Pregnancy and chlormadinone acetate.

Pregnancy and chlormadinone acetate.


Short-term habituation of the auditory evoked response in man.


Evoked response audiometry under sedation.


Dentoesthetics thru visual aids.

Dentoesthetics thru visual aids.


Tumours, hormones, and cellular differentiation.


Pregnancy following cadaver kidney homotransplantation.


Diabetic lacy vacuolation of iris pigment epithelium; a histopathologic report.


Microtubules in retinoblastoma.

Microtubules in retinoblastoma.


New technique for preparing sheets of pure corneal epithelium.


The interplatelet zone.

The interplatelet zone.


A search for the platelet secretory pathway using electron dense tracers.


Ultrastructure of hereditary telangiectasia.


Pulmonary artery hypertension in infants with congenital heart disease. Palliative management by pulmonary artery binding.


The binding of crystal violet by isolated bacterial cell-wall material.


Lactate dehydrogenase isozymes of thyroid tissue in various thyroid gland diseases.


Cytochemical observations on the localization of sulphydryl groups in budding yeast cells and in the phialides of Penicillium notatum Westling during conidiation.


Unique staining of vasa recta of kidney by o-phthalaldehyde.


Effect of prenatal povidone-iodine perineal antisepsis on serum protein-bound iodine.


Thio-tepa chemotherapy for ovarian carcinoma. Influence of remission and toxicity on survival.


Hypoglycemia associated with serous cystadenocarcinoma of the ovary.


Effects of estrogens on pressor responses to angiotensin and renin.


Effect of immunosuppressive agents on retention of antigen in the mouse spleen.


Histochemical demonstration of acetylcholinesterase in the hypothalamus of the female guinea-pig.


Studies on the spectrum of globulins in encephalomyelitis disseminata.


Lymphographic demonstration of cisterna chyli trauma. Intralymphatic injection of patent blue violet during operation.


Leucocytic infiltration into the hypoglossal nucleus following injury to the hypoglossal nerve.


Hereditary resistance to coumarin anticoagulant drugs in man and rat.


Variations in metabolism of coumarin anticoagulant drugs.


IV. Pharmacogenetics and drug toxicity. Variation of drug metabolism in animals and the prediction of drug action in man.


Effect of the fluorescein to protein ratio on anti-Treponema pallidum conjugates. The effect of using different labeling techniques and various amounts of fluorescein-isothiocyanate was tested with several pools of antisera to Treponema pallidum. Optimal labeling occurred in all serum pools at a fluorescien to protein ratio of 15. The use of pure dye and the dialysis method of labeling is recommended as the method of choice because of its effectiveness in the reduction of nonspecific staining.


The "free thyroxine index".

The "free thyroxine index".


Physiologic and clinical estimates of the relief of nasal flow obstruction in allergic rhinitis: effects of a topical decongestant (oxymetazoline).


Inhibition of human skin collagenase by human serum.


A dependant drainage balloon catheter.

A dependant drainage balloon catheter.


An oral combination of antihistamines and nasal decongestants.


Recurrent chylous ascites.

Recurrent chylous ascites.


Diagnosis of systemic lupus erythematosus semiquantitative immunofluorescent method of LE factor determination in frozen and paraffin sections.


Morphology of rat liver cells in chronic carbon disulfide poisoning.


Usefulness of cytochemical and electron microscopic investigations for the evaluation of the degree of liver cell damage in human biopsy material.


Electrophoretic investigations of proteins of the corneal epithelium in experimental photophthalmia.


A general method for the specific staining of intracellular antigens with ferritin-antibody conjugates. A general method is described whereby an intracellular macromolecule can be specifically stained with its antibody conjugated to ferritin. In this method cells or cell organelles are fixed, embedded in bovine serum albumin cross-linked with glutaraldehyde or formaldehyde, and then sectioned. This procedure preserves antigenic determinants as well as the cellular ultrastructure. The application of the ferritin-antibody conjugate to the section produces specific staining of the exposed antigen.


Phase difference in the induction of tyrosine hydroxylase in cell body and nerve terminals of sympathetic neurones. The induction of tyrosine hydroxylase in the nerve terminals of the rat heart by reserpine lags behind that in the stellate ganglion by two to three days. Cycloheximide given three days after reserpine blocks the further rise of the enzyme in the nerve terminals. The increase in tyrosine hydroxylase activity of the lumbar ganglion is as marked as that in the stellate ganglion. The increase of enzyme activity in the sciatic nerve after reserpine administration resembles that found in the heart nerve terminals. Determination of enzyme activity in segments of sciatic nerves indicates a two-day lag and then a proximal-distal transport of enzyme, but the apparent rate is not sufficient to account for the increase in enzyme in the nerve terminals. These findings are compatible with the local synthesis of induced tyrosine hydroxylase in the nerve terminals rather than the peripheral movement of the completed enzyme.


Big E.

Big E.


Mycobacteriology laboratory methods. Rep No 323.


Light and electron microscopic study of the pars intermedia of the lizard, Klauberina riversiana.


Prevention and treatment of erythroblastosis fetalis.


Classes of blood-group antibodies.

Classes of blood-group antibodies.


Biochemical changes in serum of pure and mixed Streptococcus faecalis and Bacillus subtilis infections in rats. Rats inoculated with Streptococcus faecalis developed endocarditis and demonstrated a 6- to 30-fold increase in aldolase, isocitric dehydrogenase, phosphohexose isomerase, and lactic dehydrogenase. The animals infected with Bacillus subtilis did not develop overt disease nor significant increases in enzyme activities, but viable organisms were recovered at 2 weeks. Rats inoculated with mixed culture of these organisms showed a 2- to 10-fold increase of enzyme activities without evidence of pathological anatomic changes. Both organisms were recovered at necropsy. The total protein and glycoproteins followed the patterns of enzyme activities. There were major changes in alpha(1), alpha(2), and beta globulins and glycoglobuulins at the early stages of infection. The protein-bound hexose changes coincided with the severity of S. faecalis infection, but were at normal levels after 72 hr of infection of B. subtilis and S. faecalis mixed infections. The results indicate that B. subtilis infection modified the pathogenicity of S. faecalis and by an unknown mechanism affected protein and glycoprotein production in serum of experimental rats.


Diagnostic staining of neoplastic skin lesions with toluidine blue.


Metachromatic granules in cultured fibroblasts in Morquio's disease.


Report of the Joint Efforts by the Physicians in Schools Committee of the Los Angeles County Medical Association and the Los Angeles City Unified School District to Meet the Special Health Education Needs of Children in Grades 5 and 6 of the Elementary School.


Treatment of acute otitis media: a controlled study of 142 children. Results of the use of ampicillin, penicillin G and symptomatic therapy in the treatment of acute otitis media in 142 children were compared. Antibiotic therapy conveyed significant benefit. No major differences were observed between penicillin and ampicillin, except in the age group under 3 years where ampicillin was associated with the best results. Ampicillin appears to be the drug of choice. Its superiority over symptomatic therapy was statistically significant. Long-term sequelae were not observed in any of the three treatment groups. The relative merits of erythromycin and ampicillin require further study.


Alpha 1-antitrypsin deficiency and emphysema.


Another polyendocrine disorder: pheochromocytoma and diffuse toxic goiter.


Innovations in teaching physical therapy.


Audio-tutorial independent study of goniometry.


Establishing boundary lines for families of children with behavior disorders.


Monoclonal gammopathy, thyroid crisis and congenital heart disease in a patient with trisomy syndrome (Down's syndrome or mongolism).


Gastrointestinal protein loss in toxaemic patients.


Observations on the histochemical and chemical distribution of glycogen in the chick heart.


A review of the use of audiovisual equipment in psychotherapy.


Histology of the para-anal sebaceous glandular organs of the bat Eonycteris spelaea (Chiroptera: Pteropidae).


Nuclear sex dimorphism in the Mongolian gerbil.


Cobalt as a vital stain for yeast mitochondria in squash preparations.


Newer methods of evaluating fetal maturity.


Adrenalcorticosteroid and salicylate actions on human and canine haversian bone formation and resorption.


Congenital insensitivity to pain and its orthopedic implications.


Effect of pH, bicarbonate, and acetazolamide and active release of cellular histamine.


The nail in lichen planus.

The nail in lichen planus.


An ultrastructural study of cell junctions in pemphigus vulgaris.


The ganglion psalterii (Spiegel). A brief review of anatomical and physiological aspects of the subfornical organ in mammals.


The termination of callosal fibers in the paravisual cortex of the rat.


Gammaglobulin in experimental tuberculosis and its therapeutic application in pulmonary tuberculosis.


Serological characteristics of particulate antigens of Dermatophilus.


Electron microscopic evidence for a double hair-like nap appearing at low frequency on Bacillus anthracis Sterne spores.


A training program in language and motor skills for culturally-deprived children.


The hospital incidence and clinical significance of congenital heart malformations resulting from rubella embryopathy. A retrospective study is reported of 75 children with rubella embryopathy syndrome, admitted to the Health Centre for Children, Vancouver General Hospital, during the four-year period from July 1, 1964 to July 1, 1968.Sixty-four of the 75 had cardiovascular malformations, 37 had ophthalmological defects, 31 had nerve deafness and three were mentally retarded. The most common cardiovascular defects were patent ductus arteriosus (36 patients), ventricular septal defect (22 patients) and pulmonary valvular stenosis (17 patients).Ninety-three per cent of the mothers had a history of exposure to rubella during their first trimester.The administration of gamma globulin to mothers exposed to rubella did not prevent fetal damage.Although this group of patients accounted for only 6% of children requiring open-heart surgery, it did account for 27% of the children having closed-heart surgical procedures and 10% of the case load of the cardiac catheterization laboratory.


The detection of Treponema Pallidum by a rapid, direct fluorescent antibody darkfield (DFATP) procedure.


Depression of mitosis by gamma-globulin from splenic x-irradiated animals.


A comparison of carneal epithelium regeneration in normal and buphthalmic rabbits.


Studies on MOTT bacilli (Mycobacteria other than tubercle bacilli).


Urinary tract malakoplakia: report of a fatal case with ultrastructural observations of Michaelis-Gutman bodies.


Tracheoesophageal fistula due to cancer.


An improvement of Weigert's resorcin fuchsin stain.


Metastatic colorectal carcinoma. Response to hepatic infusion. A review.


Radioimmune assay for histocompatibility antigens.


The importance of careful examination in the early diagnosis of squamous cell carcinoma of the tongue.


The innervation of the cat spleen.

The innervation of the cat spleen.


A study in intracardiac conduction.

A study in intracardiac conduction.


Clinicopathological conference: a seventy-one year old man with weakness, weight loss and change in bowel habits.


Progress in abating air pollution.

Progress in abating air pollution.


The alpha-foetoprotein test for liver cancer.


Effect of rabbit antilymphocyte gamma-globulin in mice tolerant or sensitized to normal rabbit gamma-globulin.


Development of an antifertilization test in rabbits. A sensitive method to test steroids for antifertilization activity in rabbits is outlined.  Animals in synchronized estrus and without corpora lutea receive .5 mg daily oral chlormadinone acetate or 1 mg.  daily progesterone administered subcutaneously for 8 days beginning on Day 21 after sterile mating.  Artificial insemination and administration of 25 I.U. human chorionic gonadotropin is performed on Day 27.  The animals are sacrificed 48 hours later and the ovaries inspected for ruptured, hemorrhagic, and ripe follicles, and the presence of corpora lutea.  The genital tract is inspected for unfertilized, fertilized, and degenerating eggs.  In this developing experiment, unfertilized eggs were recovered.


In situ analysis of normal and abnormal patterns of the mitotic apparatus in cultured rat-kangaroo cells.


Some properties of hyalin: the calcium-insoluble protein of the hyaline layer of the sea urchin egg. The principal protein component of the hyaline layer of sea urchin eggs is the calcium-insoluble protein first described by Kane and Hersh. The protein hyalin is abnormally high in acidic amino acids, almost devoid of basic amino acids, and characteristically rich in valine and proline. Essentially all of the cysteine present is found in the disulfide form; no evidence points to intermolecular disulfide linkages. Hyalin from several species has a minimal subunit weight of about 100,000, though evidence exists for a particle three times this weight in urea or guanidine hydrochloride from one species. Optical rotatory dispersion measurements indicate no alpha-helix content, though the dispersion has unique characteristic features. Addition of small quantities of calcium causes hyalin to gel to a birefringent fibrous form. The fibrous, birefringent form of hyalin is rendered isotropic upon addition of EDTA, but the birefringence is restored with re-addition of divalent cation.


The isolation of a major structural element of the sea urchin fertilization membrane. Procedures for isolating the contents of the cortical granules from the ova of the sea urchin, Strongylocentrotus purpuratus, are reported. Dithiothreitol is used to remove the vitelline coat; the "demembranated" eggs are then subsequently activated with butyric acid. By means of these procedures, the hyaline protein and crystalline or paracrystalline material have been isolated from the cortical granules. The crystalline material consists of sheets of cylinders or tubules 150-200 A in diameter. This material is believed to be a major structural element of the fertilization membrane which, in the absence of the vitelline coat, does not form.


Development of the spore wall during ascospore formation in Saccharomyces cerevisiae.


Cytochemical localization of endogenous peroxidase in thyroid follicular cells. Endogenous peroxidase activity in rat thyroid follicular cells is demonstrated cytochemically. Following perfusion fixation of the thyroid gland, small blocks of tissue are incubated in a medium containing substrate for peroxidase, before being postfixed in osmium tetroxide, and processed for electron microscopy. Peroxidase activity is found in thyroid follicular cells in the following sites: (a) the perinuclear cisternae, (b) the cisternae of the endoplasmic reticulum, (c) the inner few lamellae of the Golgi complex, (d) within vesicles, particularly those found apically, and (e) associated with the external surfaces of the microvilli that project apically from the cell into the colloid. In keeping with the radioautographic evidence of others and the postulated role of thyroid peroxidase in iodination, it is suggested that the microvillous apical cell border is the major site where iodination occurs. However, that apical vesicles also play a role in iodination cannot be excluded. The in vitro effect of cyanide, aminotriazole, and thiourea is also discussed.


A fine structural study on the merozoite of Eimeria tenella with special reference to the conoid apparatus.


Irreversible methylcholanthrene-induced thyroiditis in Buffalo strain rats.


The "9+1" pattern of microtubules in spermatozoa of Mesostoma (Platyhelminthes, Turbellaria). The living spermatozoa of the flatworm Mesostoma georgianum have a sperm body about 100 mu long and 0.5 mu wide, and two motile free flagella, ca. 200 mu long. In sections examined with the electron microscope, these flagella have the usual nine pairs of peripheral doublet microtubules and have a single central core unit which is connected to the A members of the doublets by spokelike structures. There are also short connections between the doublets and the flagellar membrane. In material negatively stained with phosphotungstic acid, the doublet microtubules seem to have very different elastic properties than the core; they tend to fall on the copper grids in coils of rather uniform diameter (2-4 mu), while the core is much more rigid and is often found extending alone, along a relatively straight course, for very long distances (up to 73 mu). After negative staining, the core has a striking appearance with a dense center around which are wound two hollow structures in a double helix of 45 degrees pitch. The center-to-center distance of each gyre is approximately 650 A, and the hollow structures are ca. 180 A in diameter.


Morphological studies of the Kupffer cells in tumor-bearing hosts through the silver impregnation.


Softening of the cartilage and arthritis of the rheumatoid type. Discussion in relation to classical aspects of chondromalacia.


Electrophoretic behavior of sonicated human serum proteins.


Cataracta brunescens, deafness and arthropathy.


Metachromatic leucodystrophy.

Metachromatic leucodystrophy.


Proteolytic enzymes in the skin. 3. Studies on the extractability, stability and modifier characteristics of the caseinolytic enzymes in the rat skin.


Further studies on the peroxidation of the surface lipids of the skin of rodents.


Cross-sensitization between synthetic primin and related quinones.


Allergic contact dermatitis caused by paper.


An electron microscope study of the band structure of the leprosy bacillus and other mycobacteria.


The experimental use of oral phenylalanine mustard in the treatment of malignant melanomas.


Routine patch testing V. Correlations of reactions to the site of dermatitis and the history of the patient.


Aspects of the natural history of herpes zoster. A follow-up investigation of outpatient material.


Leg ulcers. A report of two cases caused by sarcoidosis.


Rapid myelin sheath staining in paraffin, frozen and celloidin sections. A new modification of the Weigert-Loyez staining method.


Type I dysgammaglobulinemia, systemic lupus erythematosus and lymphoma.


Studies of cryoprecipitation. 3. Hemodynamic and metabolic adaptation to a circulating single component cryoglobulin.


Metastatic thyroid carcinoma provoking hyperthyroidism, with elevated circulating thyrostimulators.


Immunofluorescence studies on the affinity of pemphigus antibodies to epithelial intercellular substances.


Isolated midbrain in cats.

Isolated midbrain in cats.


Slow potential shifts in dorsal hippocampus during "epileptogenic" perfusion of the inferior horn with high-potassium CSF.


Axonal conduction studies based on some considerations of temperature effects in multiple sclerosis.


Electroencephalographic analysis of the central action of dihydroxyphenylalanine.


Notes on glycogen deposits in Limnaea auricularia var. rufescens and the parasitic larval stages of Fasciola gigantica and Echinostoma revolutum. A histochemical study.


Averaged "after-activity" and the alpha regeneration cycle.


Motor performance and sensory-evoked potentials.


A method of measuring the potentials evoked by simultaneous stimulation of different retinal regions.


Spot welding for connecting chronically implanted electrodes.


Comparative pathophysiology of the epileptic focus.


The intranuclear organization of the pacemaker for the rabbit's theta rhythm, studied by Golgi technique.


Some remarks on epileptic psychoses in children.


EEG investigations of smallpox vaccination.


Atypical electroencephalographic findings in infants.


EEG investigations in children with lesions in the peripheral part of the visual system.


Serial observations on a case of subarachnoid haemorrhage and ophthalmoplegic migraine.


Localization of cerebral processes by the EEG and cranial scan.


Peripheral vestibular disturbances in the electronystagmogram.


Comparison of cortical responses to stimulation of thalamus and fornix.


Relations between thalamic, cortical and subperiosteal derivations of expectancy waves and orienting potentials.


Electrophysiological analysis of spontaneous repetitive serial discharges in electromyography.


Single fibre electromyography in studies of the stability of neuro-muscular transmission.


Recording techniques of rheography II, possible at the present time.


Interpretation of resting rheoencephalograms.


EEG examinations in fat embolism.

EEG examinations in fat embolism.


Electroencephalographic findings in the post-traumatic psychiatric syndrome.


EEG changes following temporary cardiac arrest and open cardiac massage.


Acute poisoning with disulfiram in a child.


Effect of Vandid on paroxysmal discharges in the EEG of epileptics.


EEG differential diagnosis of Jakob-Creutzfeldt disease.


Correlation of EEG and clinical neurological findings in babies.


The effect of transverse section of the cortex on the shape and behaviour of potential fields during epileptic activity.


Thalamo-cortical components of reaction time.


An electron microscope study of the structure of Tipula iridescent virus.


Location of antibody to horseradish peroxidase in popliteal lymph nodes of rabbits during the primary and early secondary response.


Localization of the antigen in popliteal lymph nodes of rabbits during the formation of antibodies to horseradish peroxidase.


A method for in situ cytophotometric estimation of absolute amount of ribonucleic acid using azure B1.


The thyrotropin secreting basophils in the adenohypophysis of Anoptichthys jordani.


From the history of prostatic hypertrophy. A medico-historical investigation of its pathology and palliative surgical treatment up to the beginning of the 20th century. Appendix: from the history of lithotomy. A short survey of the development of the different methods.


Tentative method of routine analysis for polynuclear aromatic hydrocarbon content of atmospheric particulate matter. 11104-02-69T.


Immune reactions to Nippostrongylus brasiliensis in the rat. 3. Some pharmacological characteristics of primary and secondary immune response in vivo.


A pathway for nutrients from the medullary cavity to the articular cartilage of the human femoral head.


Hapten-carrier specificity of rabbit homocytotropic antibody.


20th annual meeting of the histochemical society, Atlantic City, April 12-13, 1969. Symposium on hormone localization in cells and tissues.


Reactive groups in hormone cytochemistry.


Low suprapubic prostatectomy: a continuing report, 1961-1965.


Classifications of anterior pituitary cell types with immunoenzyme histochemistry.


Hypotensive therapy in stroke survivors.


Cerebellar tumours presenting with clinical features of phaeochromocytoma.


Goitre prophylaxis by addition of potassium iodate to bread. Experience in Tasmania.


Cellular localisation of Australia antigen in the liver of patients with lymphoproliferative disorders.


Intermittent left bundle-branch block without obvious heart-disease.


Increase in thyrotoxicosis in endemic goitre area after iodation of bread.


A vertebral bone-biopsy instrument.

A vertebral bone-biopsy instrument.


Joint replacement.

Joint replacement.


Insulin, obesity, and aminoacids.

Insulin, obesity, and aminoacids.


Rabies.

Rabies.


Stress, multiple sclerosis, and corticosteroids.


The colon and the surgeon.

The colon and the surgeon.


Extracorporeal fertilisation.

Extracorporeal fertilisation.


Family-planning services within hospitals.


Psychiatric units in general hospitals.

Psychiatric units in general hospitals.


Fetal sex.

Fetal sex.


Sex and gender.

Sex and gender.


Neonatal haemorrhage following maternal anticonvulsant therapy.


Treatment of carbon-monoxide poisoning.

Treatment of carbon-monoxide poisoning.


Pressure on G.M.C.

Pressure on G.M.C.


Selenium--a possible teratogen?

Selenium--a possible teratogen?


The handless and footless families of Brazil.


Death of the professor of medicine.

Death of the professor of medicine.


Echoviruses and carditis.

Echoviruses and carditis.


Cryofibrinogenaemia in patients on oral contraceptives.


Ventilation and bacterial spread in hospital.


Australia antigen and smooth-muscle antibody in acute and chronic hepatitis.


Nursing posture after acute myocardial infarction.


Who benefits?

Who benefits?


Radiation-induced breast cancer.

Radiation-induced breast cancer.


Deaths with dental anaesthetics.

Deaths with dental anaesthetics.


Effects of general anaesthetics on microbutules.


Iatrogenic leg dermatitis.

Iatrogenic leg dermatitis.


Juvenile chronic myeloid leukaemia.

Juvenile chronic myeloid leukaemia.


Leukaemia mortality in Norway.

Leukaemia mortality in Norway.


Immunoglobulin assay.

Immunoglobulin assay.


Gerald Henry Cooray.

Gerald Henry Cooray.


Cardiac surgery for the cyanotic infant.


Diamine oxidase (histaminase) in blister fluid and blood plasma during pregnancy.


The 131-I-triiodothyronine-resin uptake test during labour.


Inclusion conjunctivitis and Reiter's syndrome in a married couple. Chlamydia infections in a series of both diseases.


Malaria, anaemia and pregnancy.

Malaria, anaemia and pregnancy.


Adrenergic mechanisms in the effects of histamine in the pulmonary circulation of the cat.


Recent observations on the treatment of late ocular syphilis and neurosyphilis.


The capillary in the human cochlea.

The capillary in the human cochlea.


Application of mixed haemadsorption--a mixed antiglobulin reaction--to soluble antigens fixed on glass slides.


Recent progress in pharmacogenetics.

Recent progress in pharmacogenetics.


The evaluation of present antileprosy compounds.


Suppression of leukocytic mitosis by sera of hepatitis-implicated donors.


Atypical cytology with contraceptive hormone medication. A preliminary report.


Bronchopulmonary helminthosporiosis.

Bronchopulmonary helminthosporiosis.


Anaphylactoid purpura. 3. Early morphologic glomerular changes.


Association of parathyroid hyperplasia with neoplasia.


Lymphoid hyperplasia of the large intestine associated with dysgammaglobulinemia. Report of a case.


Isoenzymes of transaldolase in Candida utilis. I. Isolation of three isoenzymes from yeast extracts.


Cell-free transfer of leucine by transfer ribonucleic acid from mouse liver and plasma cell tumors into rabbit hemoglobin.


Anti-gamma-globulin factors in serum and tissue of cancer patients.


Cells involved in the immune response. XV. The organ source of the antigen reactive cells in the normal rabbit.


Immune reactions to Nippostrongylus brasiliensis in the rat. II. Primary and secondary immune response: in vitro characterization.


The importance of antibody concentration, binding constant, and heterogeneity in the suppression of immunity to the Rh factor.


Enhanced contrast in electron microscopy of unstained biological material. I. Strioscopy (dark-field microscopy).


Procedures for the immunization of goats with human immunoglobulins and complement.


Staining of immature collagen in cattle.


Thyroid diseases and immunoglobulin levels.


Substructure in the iron core of ferritin molecules.


The immunological deficiency diseases.

The immunological deficiency diseases.


Intractable angina pectoris.

Intractable angina pectoris.


Recognition and therapy of digitalis toxicity.


Plasma volume and plasma colloid osmotic pressure.


Determination of phenytoin in serum in the presence of barbiturates, sulthiame and ethosuximid by thin-layer chromatography.


The suitability of new drugs for intermittent chemotherapy of tuberculosis. An experimental study.


The stereostructures of pulchellidine and pulchellin.


Cortisone nephropathy in the rabbit. The effect of warfarin administration.


Quantitative immunoglobulin determination. Comparison of two methods. Estimation of normal levels and levels in persons lacking IgA and IgD.


Studies of echovirus type 6 antigens in immunodiffusion. 1. Antigen composition of native and heated virus preparations.


Phages of lysogenic Thermoactinomyces vulgaris.


Immunofluorescent studies using fractionated immunoglobulin of sera of fowls with Marek's disease.


Improvement in separation of system I and system II particles of photosynthesis obtained by digitonin treatment.


Separation, purification and some properties of pneumococcal neuraminidase isoenzymes.


The purification and properties of formamidase from rat liver.


N-Terminal sequences of equine and human immunoglobulin heavy chains.


Sex-associated urinary protein in the rat.


Argininosuccinic aciduria. A case.

Argininosuccinic aciduria. A case.


Fluorescent staining of elastic tissue with Rhodamine B and related xanthene dyes.


Combined histochemical staining of 1,2-glycol and sulfate groupings of mucopolysaccharides in paraffin sections.


The histochemical localization of lactic dehydrogenase isoenzymes in the rat nephron by means of an improved polyvinyl alcohol method.


Architectural changes in gingivitis and some implications of the plasma cell response.


New fixative solution and durable staining for mast cells.


Studies on cartilage. 3. Phosphotungstic acid (PTA) positive material in chondrocytes.


Hypothalamic neurosecretion and metamorphosis in Xenopus laevis. IV. The effect of extirpation of the presumed TRF cells and of a subsequent PTU treatment.


Choroidal nodules and retinal detachments in rheumatoid arthritis. Improvement with fall in immunoglobulin levels following prednisolone and cyclophosphamide therapy.


Enzyme histochemistry of embryonic nasal mucosa.


Electron microscopic study on the human pancreatic islets.


Neuro-ophthalmology.

Neuro-ophthalmology.


Cardiac arrest following induction with propanidid. A case report.


Prolonged survival of skin allografts in rats treated with heterologous anti-skin serum.


Immunology of reaginic allergy: in vitro studies.


Immunochemical mechanisms of immediate-type hypersensitivity reactions.


Biological function of gamma E antibodies and mechanisms of reaginic hypersensitivity.


Allergens and antigens of Dermatophagoides farinae.


Some factors influencing the serum IgE levels in atopic diseases.


Unfolding of human secretory immunoglobulin A.


The use of red blood cell stroma as an immunoabsorbent and analytical tool. I. Studies with immune sera.


Solid phase radioimmunoassay of human beta 1C globulin.


The changing role of the nurse: an alternative to elimination.


Autoantibodies in patients with thyrotoxicosis in an endemic goitre area after iodation of bread.


Drug therapy in parkinsonism.

Drug therapy in parkinsonism.


Intravascular coagulation in acute hepatic necrosis.


125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis.


Immunological picture in Indian childhood cirrhosis.


Nephrotic syndrome associated with inhaled allergens.


Iron absorption from brown bread.

Iron absorption from brown bread.


Prevention of leucocyte-antibody formation.


Clinical evaluation of a new fibreoptic colonoscope.


Toxic metabolic defect in polycystic disease of kidney. Evidence from microscope studies.


Bacterial enzymes in the gut.

Bacterial enzymes in the gut.


Poverty today.

Poverty today.


Keeping rabies out.

Keeping rabies out.


Unselective B.C.G. vaccination.

Unselective B.C.G. vaccination.


A troublesome servant.

A troublesome servant.


Monitoring in anaesthesia.

Monitoring in anaesthesia.


The plague's last visit?

The plague's last visit?


Contamination of infant feeds in a Milton milk kitchen.


Pseudomonas aeruginosa infection in a neonatal nursery, possibly transmitted by a breast-milk pump.


North Sea gas.

North Sea gas.


Incontinence pads.

Incontinence pads.


Expectorant properties of bromhexine.

Expectorant properties of bromhexine.


Atheroma in a transplanted heart.

Atheroma in a transplanted heart.


Sudden unexpected death.

Sudden unexpected death.


Treatment of arrhythmias with verapamil.


Renal-clip hypertension.

Renal-clip hypertension.


Winter and heart-disease.

Winter and heart-disease.


Remission of astrocytoma following amphotericin-B treatment.


Ideal means of fertility control?

Ideal means of fertility control?


Hyperpyrexia in antidepressant poisoning.


Antigen-binding lymphocytes.

Antigen-binding lymphocytes.


Primary sex-ratio and size of family.

Primary sex-ratio and size of family.


Gastric tissue in the rectum.

Gastric tissue in the rectum.


Treatment of drug-induced dyskinesias.

Treatment of drug-induced dyskinesias.


Possible complication of hypothermic-saline subarachnoid injection.


Platelet-collagen reaction and bleeding syndrome.


Treatment of gravitational leg ulcers.

Treatment of gravitational leg ulcers.


Virus-like structure in Sjögren's syndrome.


As a man sews......

As a man sews......


Diagnosis of colour-vision defects in young children.


Down's syndrome and infectious hepatitis.


Gluten-free diets.

Gluten-free diets.


Blood-groups and heart-disease in Bristol.


Bone abnormalities in the XYY syndrome.

Bone abnormalities in the XYY syndrome.


Recurrent laryngeal nerve at thyroidectomy.


Intrathecal methotrexate.

Intrathecal methotrexate.


Normal serum and red-cell folate levels in a child with coeliac disease.


Prevention of venous thrombosis.

Prevention of venous thrombosis.


Varicella and cytosine arabinoside.

Varicella and cytosine arabinoside.


Gonorrhoea.

Gonorrhoea.


Hospital milk kitchen.

Hospital milk kitchen.


Surgical training.

Surgical training.


L-dopa in senile dementia.

L-dopa in senile dementia.


Assessment of mentally handicapped children.


Pharmacology of the ureter.

Pharmacology of the ureter.


Severely disturbed adolescents.

Severely disturbed adolescents.


Sjogren-Larsson syndrome.

Sjogren-Larsson syndrome.


Anthony Leonard Woolf; M.D. Lond., M.R.C.P., F.R.C.Path.


Geoffrey Pryce Goodwin. M.B. Cantab., F.F.A.R.C.S.


A guide to the care of the injured patient. 2.


Results of breast cancer treatment.

Results of breast cancer treatment.


Further doubts about oral contraceptives.


Chlormadinone contraceptive withdrawn.

Chlormadinone contraceptive withdrawn.


The effect of localized injection of adjuvant material on the draining lymph node. I. Histology.


Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant.


Induction of antibody synthesis. Effect of blocking defined determinants of an antigen.


Cellular and humoral aspects of the primary immune response of the toad, Bufo marinus.


Impurities in conjugated globulins for immunofluorescence techniques.


Chromatographic characterization of tanned erythrocyte agglutinating factor in guinea pig serum.


Surgical treatment of the postphlebitic leg.


Use of suction with suprapubic bladder drainage.


Oral contraceptives, hypertension, and toxemia.


Uterine leiomyoma. Incidence of degenerative change and a correlation of associated symptoms.


The origin of cellular monolayers in tissue cultures from mouse kidney.


A selective straining reaction in malignant blood cells of man.


Trasicor: review of the pharmacology and clinical results.


Cytochemical variants of neutrophil leukocyte populations in chronic myelocytic leukaemia. A microspectrophotometric study of the change in the periodic acid-Schiff (PAS) reaction in blood and bone marrow neutrophils during busulfan treatment.


The effect of injection of chlorinated hydrocarbon pesticides on hatchability of eggs.


A method of identifying narcotic analgesics in human urine after therapeutic doses.


The neurosecretory system of the adult Calliphora erythrocephala. IV. A histological study of the corpus cardiacum and its connections with the nervous system.


Correlation between nuclear size and Feulgen-DNA value in lymphocytes.


The cytology of intrauterine contraceptive devices.


Studies on nuclear structure by staining for acidic protein in the vaginal smear.


The detection of Cryptococcus neoformans in sputum cytology. Report of one case.


Cytodiagnosis of malakoplakia. Report of a case.


A study and new description of Corynebacterium vaginale (Haemophilus vaginalis).


An improved method for the fluorochrome staining of mycobacteria in tissues and smears.


Adrenal function in hypothyroidism.

Adrenal function in hypothyroidism. In ten patients with hypothyroidism the adrenal response to stimulation with tetracosactrin was found to be normal, and to be unchanged after they had been treated with thyroxine. Though the response to insulin hypoglycaemia was less in the hypothyroid phase, it was never outside the normal limits. Hence it seems unlikely that the adrenal response to stress is appreciably lowered in hypothyroidism.


Electrocardiogram of the month.

Electrocardiogram of the month.


Application of quantitative chromatographic technique in the determination of CSF gamma globulin to MS.


Experimental glomerulonephritis in unresponsive rabbits after breaking immunologic tolerance.


Quantitative immunochemical studies of cerebrospinal fluid proteins in relation to clinical activity of multiple sclerosis.


The fine structure of the mammalian lymphoreticular system.


A simple rapid micromethod for detecting chronic granulomatous disease of childhood.


Biochemical, endocrine, and other indices during quinestrol therapy. The effect of .025 mg quinestrol twice daily for 6 months was studied in 8 menopausal and postmenopausal women.  There was no change in mean body weight, blood pressure readings, pulse rate or electrocardiograms.  Vaginal smears showed an estrogenic effect of the drug which included cornification of the vaginal epithelium.  There was a slight decrease in beta lipoproteincholesterol and serum acid phosphatase.  There was an increase in serum creatine between the third and sixth months of treatment with no change in serum creatinine.  In non-diabetic women, glucose-induced hypophosphatemia was accentuated.  In diabetic women, the glucose tolerance appeared to improve.  In both groups, increases in serum insulin caused by a glucose load were less under quinestrol therapy than without.


Dioxoisoquinoline-4-carboxanilides, novel nonsteroidal anti-inflammatory agents with a species-specific effect on basal metabolism.


Pharmacologic blockade of reflex vasodilatation: effects on postulated neurohumoral mechanisms.


Surgical palliation of hypoplastic left side of the heart.


Pain clinics.

Pain clinics.


Electron microscopy of bovine and human cervical mucus.


Retreatment of persistent and recurrent carcinoma of the cervix with irradiation.


Radiotherapeutic management of surgical recurrences and postoperative residuals in tumors of the head and neck.


Reactivity of human gamma G erythrocyte autoantibodies with fetal, autologous and maternal red cells.


Identification of parathyroid glands by toluidine blue staining.


Second-look operation for colon carcinoma after fluorouracil therapy.


Antibody-coated tube method for radioimmunoassay of human growth hormone.


A simple and rapid thin-layer chromatographic technique for the detection of methylmalonic acid in urine.


Lactate dehydrogenase isoenzyme(s) linked to IgA immunoglobulin in a patient with a myocardial infarction.


Quantitation and specific detection methods after disc electrophoresis of serum proteins.


Isoenzymes of Drosophila alcohol dehydrogenase. I. Isolation and interconversion of different forms.


Immunological activity of cytochrome c. I. Precipitating antibodies to monomeric vertebrate cytochromes c.


Immunological activity of cytochrome c. 3. Enhancement of antibody detection and immune response initiation by cytochrome c polymers.


Characterization of a nocardiophage for Nocardia restrictus.


The clinical significance of the LE cell.


The envelope of Herpesvirus.

The envelope of Herpesvirus.


Recent virologic applications of ferritin conjugates.


Automatically controlled continuous recovery of plasma protein fractions for clinical use. A preliminary report.


Depletion of lymphocytes for the protection of renal allografts.


Human sera as source of IgG subclass-specific reagents.


Keratin fibres. II. Separation and analysis of medullary cells.


Studies on the blood of the Tasmanian devil.


Regulation of non-specific phosphatases by protein charges in the amphibian kidney homogenate.


Variations of plasma kininogen content due to high sodium intake in rats.


Liquid immersion of stain-type stony fossils.


Photographing skeletal structures in small fishes.


The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation. I. The mature oocyte.


The surgery of exophthalmic ophthalmoplegia.


Comparative study on the auditory ossicles related to the pathogeny of otosclerosis.


The two types of A-cells in the islets of Langerhans of normal and synthalin-treated guinea-pigs.


Actinomyces in tonsillar tissue. A histological study of a tonsillectomy material.


The specificity of circulating antibodies in experimental infections with Mycobacterium bovis and Mycobacterium tuberculosis demonstrated by immunofluorescence.


Peroperative evaluation of the juxtaglomerular apparatus in human kidneys. A rapid frozen-section technuque especially applicable to hypertensive patients.


Studies on Yersinia enterocolitica with special reference to bacterial diagnosis and occurrence in human acute enteric disease.


Immunoglobulin E.

Immunoglobulin E.


Cross-resistance between agents which condition for acute necrosis.


Loss of rubella antibody from immune globulin treated with kaolin. Sera and immune globulin (IG) preparations are customarily treated with kaolin before titration of their rubella hemagglutination-inhibiting (HI) antibody in order to rid them of nonspecific inhibitors of hemagglutination. The treatment was shown in this investigation to have no adverse effect on the antibody level of the sera but was found to remove considerable amounts of gamma-globulin from IG preparations. Evidence of this removal was obtained by serological tests, by spectrophotometric determination of protein concentration and by disc electrophoresis. In contrast to kaolin, heparin-manganese chloride (MnCl(2)) treatment of IG preparations had essentially no effect on the level of antibody globulin by all the criteria used. Heparin-MnCl(2)-treated IG lots were in these respects similar, if not identical, to their untreated counterparts. Since nonspecific inhibitors associated with the beta-lipoprotein fraction of serum are removed by the method employed to fractionate the IG samples, it seems unnecessary to treat the latter in any way for the HI test. No difficulty was encountered in this investigation with several untreated IG lots.


A simplified procedure for spinal fluid cytology.


A study of posters in dental health education.


Clinical evaluation of mepivacaine and lidocaine.


Individuality in development.

Individuality in development.


The influence of various pharmacological agents on the desynchronization produced by DOPA in the cerveau isolé preparation.


Hippocampal responses to neocortical stimulation in the chloralose-anesthetized cat.


Electroencephalographic signs employed in the location of ruptured intracranial arterial aneurysms.


Some aspects of so-called "petit mal status".


Immunoenzyme techniques: enzymes as markers for the localization of antigens and antibodies.


Comparison of three methods of teaching oral hygiene to school children.


Interferon and respiratory syncytial virus.


Carcinoma of the oesophagus after gastric surgery.


Prenatal diagnosis of Tay-Sachs disease.


Xg blood-groups and clonal-origin theory of chronic myeloid leukaemia.


Possible inherited leukaemogenic factors in familial acute myelogenous leukaemia.


Association between circulating haemoglobin level, serum-cholesterol, and blood-pressure.


Modification by L-dopa of a case of progressive supranuclear palsy. With evidence of defective cerebral dopamine metabolism.