Postoperative analgesia with hydromorphone and meperidine: a double-blind comparison.


Dicoumarol biosynthesis: origin of the methylene bridge.


Prevention of rhesus immunization. A controlled clinical trial with a comparatively low dose of anti-D immunoglobulin. A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 mug) in preventing rhesus immunization.In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.


Slow potential changes in the human brain associated with expectancy, decision and intention.


Possibility of the clinical use of sensory evoked potentials transcranially recorded in man.


Evoked potential studies in response to light in the baboon (Papio papio).


Serum fibrin degradation products throughout normal pregnancy. Fibrin/fibrinogen degradation products in the serum of 169 healthy pregnant and 43 healthy non-pregnant subjects of a similar age group showed a significant increase throughout pregnancy, the highest levels being obtained in the third trimester. There was no correlation with plasma fibrinogen levels or euglobulin lysis times. Though these changes may be due to other alterations in pregnancy not primarily associated with fibrinolysis, it is possible that actual fibrinolysis is not decreased in late pregnancy, as has been previously asssumed.


The spatial sum of evoked responses to a single stimulus (light or sound) recorded from the human scalp.


Somato-sensory evoked potentials in thalamus and cortex of man.


Nervous mechanisms underlying phasic changes in thalamic transmission during deep sleep.


Pharmacologically induced alterations of cortical and subcortical evoked potentials compared with physiological changes during the awake-sleep cycle in cats.


Cerebellar system evoked responses: the effect of ascending inflows upon single unit activity in the inferior olives in the cat.


Bibliography of human evoked potentials.


Click-evoked responses in cats with tenotomized middle ear muscles during sleep and waking.


Analysis of antibody staining patterns obtained with striated myofibrils in fluorescence microscopy and electron microscopy.


Binding properties of a Waldenström macroglobulin antibody.


Serum measles antibody titers in patients with subacute sclerosing panencephalitis, compared with parents and siblings.


The effect of vasopressin on hormone secretion and blood flow from the thyroid vein in sheep with exteriorized thyroids. 1. Vasopressin has been shown to activate the thyroid in some species, and also to be released into the bloodstream after emotional and other stresses.2. Emotional stimuli applied to sheep have previously been shown to increase thyroid secretion and the possible influence of vasopressin in this process has been investigated. Sheep bearing exteriorized thyroid glands were used, so that thyroid vein blood could be collected in undisturbed conscious animals.3. (125)I or (131)I (50 muc) was injected I.M. into the sheep; 4-7 days later, samples of thyroid vein blood were collected at 10 min intervals for 4 hr, and the concentration of total and protein bound (125)I or (131)I was measured. Intravenous infusions of 0.3, 3.0 or 31 m-u./min arginine or lysine vasopressin, or close arterial infusions of 3.0 or 31 m-u./min arginine vasopressin were administered 1.5 hr after commencement of blood sampling. Blood flow from the thyroid was measured by a plethysmographic technique during similar experiments.4. No significant changes in thyroid hormone secretion were observed as a result of vasopressin infusion, and it was concluded that vasopressin release does not play a part in the activation of the thyroid resulting from emotional stimulus in the sheep.


Effectiveness, reproducibility, and weight-relation of screening-tests for diabetes.


Theories and hypotheses in social psychiatry: an analysis of the evidence.


C'3 synthesis in the human fetus and lack of transplacental passage. Allotypic differences in the third component of complement between mothers and their newborns provided evidence for synthesis of this complement component by the fetus. There was no indication that this protein traversed the placenta. The known low level of C'3 in the neonate was confirmed, and the maternal concentration was found to be significantly elevated.


Liquid detergent in aqueous fixing fluids, to promote rapid wetting and sinking of plant specimens.


Vital staining by Procion navy blue M3RS in laboratory mammals.


Staining of pathogenic fungi with Gomori's aldehyde-fuchsin in both old and new sections.


The diazosafranin method; control of nitrite concentration and refinements in specificity.


Accelerated clearing of plant leaves by NaOH in association with oxygen.


Rapid one-solution differential staining with textile dyes: Pontacyl dark green B and Pontamine fast scarlet 4BA.


Staining methods for calcium--a comparison based on reactions shown by cardiac calcinosis in DBA mice.


Gross differential staining of the hypophysis.


Metachromatic reaction of pancreatic B cells to toluidine blue; influence of pH on staining.


Diastase removal of glycogen from sections or smears after staining.


Genetics of the immune response. Report of a WHO Scientific Group.


Ultrastructure of the surfaces of cells infected with avian leukosis-sarcoma viruses. When stained with ruthenium red (RR), chick embryo cells infected with various strains of Rous sarcoma virus (RSV) and with avian leukosis viruses RAV-1 and RAV-3 showed an increase in the layer of acid mucopolysaccharides (AMPS) at their surfaces as compared with uninfected cells. This increase was most prominent in cells infected with the Fujinami strain of RSV. The layer was resistant to digestion with neuraminidase or trypsin but was readily removed by exposure to hyaluronidase. The thickness of this AMPS layer was not correlated with the varying degree of loss of contact inhibition exhibited by cells infected with the different strains of virus. The staining of the cell envelope with a solution of phosphotungstic and chromic acids (PTA-CR) suggested the presence of glycoproteins. The outer surface of the virions showed the same staining as the cell surface with RR and PTA-CR, and the budding virus particle was seen to incorporate the RR layer of the cell into its structure. The RR layers of cells and virions appeared to fuse, as did those between virus particles, suggesting that these layers play a role in the aggregation of virus particles and in their adherence to the surface of the cell.


Slide photography improves dental education.


A fibrillar intercellular material between reaggregating embryonic chick cells. Lanthanum staining of embryonic chick cell reaggregates reveals an intercellular material composed of fibrils. Fibrillar arrays may be composed of parallel fibrils with a 35 A center-to-center spacing. Fibrils may also be disoriented, long, and tortuous. Newly dissociated cells show little lanthanum staining surface material, but appreciable amounts are present after 6 hr of reaggregation. Examination of intact tissue does not give the same clear evidence of a fibrillar matrix surrounding the cells, but treatment with a number of agents permits observation of intercellular fibrils, and in some cases there is evidence of orientation. Thus fibrillar material must be taken into account in considering mechanisms of cell aggregation.


Establishment of a clonal strain of hepatoma cells which secrete albumin. A clonal strain of epithelial cells (designated MH(1)C(1)) has been established from the transplantable Morris hepatoma No. 7795. The cells have maintained distinctive morphology throughout more than 20 subcultures (split 1:5) at 2- to 4-week intervals in supplemented Ham's F 10 medium. They contain many highly refractile, round, cytoplasmic bodies which stain bright red with Oil Red O. The population doubling time was 2 wk when the clonal strain was first established. It has gradually decreased to 1 wk. The cells synthesize rat serum albumin and secrete it into the culture medium as determined immunologically by microcomplement fixation and double diffusion. Albumin secretion (3-6 microg albumin/mg cell nitrogen/24 hr) occurs throughout the logarithmic phase of cell proliferation and has not diminished during serial propagation since the strain was initiated 15 months ago.


Use of potassium pyroantimonate in the localization of sodium ions in rat kidney tissue. Potassium pyroantimonate added to fixative solutions has been used in tissue localization of sodium ions. The distribution and specificity of the resulting precipitate in rat kidney is described in this study. Two reproducible patterns of precipitate were obtained in control tissues. The first pattern, which occurred after fixation in solutions containing aldehyde, showed the precipitate to be mainly extracellular. The second pattern, showing the precipitate in both intracellular and extracellular locations, occurred after aldehyde fixation in those experimental situations favoring cellular swelling or after fixation with solutions containing osmium tetroxide. It appeared that sodium ions could move after fixation but that sodium pyroantimonate precipitate could not. Since model systems demonstrated that dense precipitate formed when potassium pyroantimonate was added to solutions containing certain biological amines or some divalent cations, it appeared likely that the reagent did not provide specific tissue localization for sodium ions.


Sites of nucleolus production in cultured Chinese hamster cells. Chinese hamster cell strains in the early passages in culture display wide variation in number of nucleolus-like bodies per cell, though such strains are characteristically euploid. A variety of criteria indicate that the nucleolus-like bodies are true nucleoli. Their Azure B- and fast green-staining properties indicate the presence of RNA and protein; they have typical nucleolar fine structure, including both fibrous and granular components; radioautography reveals that their patterns of uptake of uridine-(3)H into RNA are similar to those reported for nucleoli of other cell types; actinomycin D, at a level which selectively inhibits ribosomal RNA synthesis, greatly reduces their RNA synthesis and also causes segregation of fibrous and granular nucleolar components. Colchicine was used to experimentally fragment the nuclei of these cells into a number of separate karyomeres, each presumably containing some, or only one, of the chromosomes of the complement. Almost all the karyomeres contain nucleolus-like bodies which, by the same criteria applied to the multiple nucleolus-like bodies of uninuclear cells, appear to be true nucleoli. The nucleoli of individual karyomeres of the same cell often differ from each other in fine structure while the multiple nucleoli of a uninuclear cell generally resemble each other. The evidence presented in this study indicates that Chinese hamster cells contain many nucleolus-producing sites scattered through the genome.


Structural changes of isolated rat peritoneal mast cells induced by adenosine triphosphate and adenosine diphosphate.


The essential elements in educating patients.


Protein and immunoglobulin content of rete testis fluid of rams.


Marionette show of the Women's Auxiliary to the Greater St. Louis Dental Society.


PDA member receives 25,000 dollars "loss of use of hands" benefit through group insurance plan.


Two years' experience with renal transplantation.


Dental plaque and the streptococci as etiological agents in dental caries.


Clinical evaluation of Fiorinal with codeine in control of pain of dental origin.


Adapted dental chair for the wheel chair patient.


Studies on the radiosensitive phase of the antibody response. 3. Recovery and the secondary response: USNRDL-TR-68-69.


Systemic 5-fluorouracil for palliation of gastrointestinal cancer.


Development of new instructional materials in the IMC network.


Extraction of crystal violet-iodine complex from Gram positive bacteria by different solvents and its implication on Gram differentiation.


Pituitary ablation, insulin dosage, and course of diabetic retinopathy.


Some aspects of the oto-toxic antibiotics.


The electron-microscopy of the osmiophilic granules of the synaptic terminals.


The prevention of infection in cardiac transplantation.


Immunochemical quantitation of serum beta1A-globulin in health and disease.


Two thousand woman-years' experience with a sequential contraceptive. A more effective method of taking a sequential contraceptive.


Presence of corpus luteum as evidence of ovulation in women treated with low doses of chlormadinone acetate. 50 women under continuous treatment for 1-31 months with 500 mcg chlormadinone acetate daily were studied.  Culdoscopy was performed between Day 14 and 23 of their menstrual cycles.  A corpus luteum was thought to be observed in 37 cases.  In 18 with suspected corpus luteum a wedge resection of the ovary was done.  Examination of patients 10 days after operation revealed no complications.  In 4 cases subsequent culdoscopic examinations revealed no traces of biopsy damage.  In 5 an endometrial biopsy was obtained the same day as the ovarian one or shortly thereafter.  The 18 ovarian biopsies showed recent corpora lutea in 12, old corpus luteum in 1, follicular and theca-lutein cysts in 2, and normal follicles without corpus luteum in 3.  Endometrial biopsies revealed 2 instances of normal secretory endometrium and 1 case of irregular endometrium with corpora lutea.  Evidence of ovulation occurred in 70%.  The reported pregnancy rate with low-dose progestogen therapy has been 3.7/100 years of woman exposure.  The exact mechanism of contraception by chlormadinone acetate has not been determined.


Loudness recruitment and its measurement with special reference to the loudness discomfort level test and its value in diagnosis.


The structure of human immunoglobulins.

The structure of human immunoglobulins.


Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. II. Effects of hemin and bilirubin on enzyme induction.


Optimal oxygen tension for human lymphocytes in culture.


The liver during recovery from protein-calorie malnutrition.


Host fixation and kinetics of antitissue antibodies.


The monocyte-histiocyte-system.

The monocyte-histiocyte-system.


Occurrence of large hyaline bodies in the preoptic nerve cells of Zoarces viviparus L.


On lipid droplets in renal interstitial cells. I. A histochemical study.


On the histochemical differences of aldehyd-fuchsin positive material in the fibres of the hypothalamo-hypophyseal tract of rana temporaria.


The demonstration of phospholipids in certain cells in neurosecretory nuclei in the rat with Baker's acid Haematein after Fixation in glutaraldehyde-formol-calcium.


Studies on microatomized protein foods based on blends of low fat groundnut, soy, and sesame flours, and skin-milk powder and fortified with vitamins, calcium salts, and limiting amino acids. V. Relative efficacy in the treatment of kwashiorkor.


A modification for the combined staining of cells and fibers in the nervous system.


President's page. A. A. O. Audio-Visual Library.


A unified urological nursing unit.

A unified urological nursing unit.


As I see it: O. R. education.

As I see it: O. R. education.


Our students wear white hats.

Our students wear white hats.


Member in the spotlight (Ina Love Williams).


Committee at work. National Membership Committee.


Bone resorption.

Bone resorption.


Effect of vitamin A in vitro on histamine release and structure of mast cells.


Lasting changes in acriflavine-binding induced in mammalian cells by exogenous DNA.


Ultrastructural localization of antibody by antigen label with peroxidase.


Urgent extensive operation in cases of thyroid malignancy.


Inhibition of membrane transport in Streptococcus faecalis by uncouplers of oxidative phosphorylation and its relationship to proton conduction. We studied the effect of compounds that uncouple oxidative phosphorylation on membrane function in Streptoccocus faecalis, an organism which relies upon glycolysis for the generation of metabolic energy. At low concentrations (ranging from 10(-7) to 10(-4)m), tetrachlorosalicylanilide, tetramethyldipicrylamine, carbonylcyanide m-chlorophenylhydrazone, pentachlorophenol, and dicoumarol strongly inhibited energy-dependent transport of rubidium, phosphate, and certain amino acids. However, these compounds had little effect on the generation of adenosine triphosphate via glycolysis or on its utilization for the synthesis of macromolecules. They also did not seriously inhibit uptake of those monosaccharides and amino acids which do not require concurrent metabolism. It is proposed that the uncouplers interfere with the utilization of metabolic energy for membrane transport. The uncouplers accelerated the translocation of protons across the cytoplasmic membrane. It appears that a proton-impermeable membrane is required for transport, perhaps, because a proton gradient is involved in the coupling of metabolic energy to the translocation of substrates across the membrane.


Isolation and properties of an actinomycin sensitive mutant of Escherichia coli.


Fungus photography: culture plates with ultraviolet fluorescence.


Skin grafts and the care of the grafted patient.


An audio-visual approach to employee orientation in a small institution.


Utilization of videosonic equipment with mentally retarded.


A case study: total hysterectomy.

A case study: total hysterectomy.


Symposium on operating room nursing. Foreword.


Expanding horizons in operating room nursing.


Toward a more effective program of operating room administration.


The case for operating room technicians.


Preparation of the professional nurse for practice in the operating suite.


Effective teaching of nursing in the operating room through newer media.


Patient-centered care in operating room nursing.


Care of laminectomy during pregnancy.

Care of laminectomy during pregnancy.


Operating theatre staffing.

Operating theatre staffing.


Passive cutaneous anaphylactic-like reactions in young chicks.


Inhibition of Trichinella spiralis complement fixation by immune macroglobulin.


Pharmacologic dissociation of immunologic release of histamine and slow reacting substance of anaphylaxis in rats.


Spectrum of ovine immunoglobulins.

Spectrum of ovine immunoglobulins.


Immunoglobulin in fetal lamb lung and its fluid.


High-risk surgery: nursing care of head-and-neck surgical patients.


Percutaneous cordotomy for relief of intractable pain.


Preparative electrophoresis of serum proteins on plaster of paris.


Protein-bound iodine after urinary tract radiography with hypaque.


A new immunodiffusion method for quantitative determination of proteins in biological fluids based on a separate application of antibody and antigen to small agar discs.


Prevention of cracking of wells in the immunodiffusion agar-plate.


The quantitative relationship between anxiety-depressive states and the triiodothyronine I-131 binding capacity of alpha and beta globulins--a biochemical test and graphic index for investigation of protein-hormonal physiology in psychiatric disorders.


Genetic control of dicumarol levels in man. The mean half-life of dicumarol in the plasma of seven sets of identical and seven sets of fraternal twins after a single oral dose of 4 mg/kg was 43.6+/-SD 17.9 hr. Half-lives ranged from 7 to 74 hr in these 28 normal adults not receiving other drugs for 2 wk preceding dicumarol administration. Large differences among unrelated individuals in dicumarol half-life disappeared almost completely in identical twins, but persisted to some extent in most sets of fraternal twins. These results indicate that marked differences among subjects in dicumarol half-life are under genetic rather than environmental control. Reproducibility of values for dicumarol half-life was demonstrated. A direct relationship between the dose and the half-life of dicumarol occurred in unrelated volunteers administered progressively larger doses at 10-day intervals. Dose dependence of the half-life of a drug results in increased variability of half-life and hence in greater risks of toxicity on long-term therapy. Risks of toxicity on the one hand and of failure to anticoagulate adequately on the other can be reduced by determining dicumarol half-life before starting long-term therapy. Half-lives for dicumarol and phenylbutzone tended to be correlated in the 28 twins, but no correlation occurred between dicumarol and antipyrine half-lives.


Cardiac care research with television.

Cardiac care research with television.


The immunoglobulins in health and disease.


Goitrogenic effects of (minus)-5-vinyl-2-oxazolidinethione, a goitrogen in rapeseed, in growing chicks.


Advances in the treatment of virus diseases.


Protein bound iodine. General.

Protein bound iodine. General.


Hyaline droplet formation in the renal epithelium of patients with haemoglobinuria. Renal hyaline droplet formation is described in two patients with haemoglobinuria. The droplets were shown to contain haemoglobin by a histochemical method. The findings are correlated with the results of recent experimental studies which have demonstrated that renal hyaline droplets are phagosomes containing absorbed protein and not products of cellular degeneration as was previously thought.


Hyaline cast formation in patients treated with cephaloridine. The administration of 6 g. cephaloridine daily produced large numbers of hyaline casts during treatment, occasionally accompanied by red and white cells and albumin. These cleared when treatment ended and are of uncertain and doubtful significance.


Observations on the levels of gamma G, gamma A, gamma M globulins, anti-A and anti-B agglutinins, and antibodies to Escherichia coli in Down's anomaly. The levels of gammaG, gammaA, and gammaM globulins were estimated in a group of patients with Down's anomaly and in groups of mentally retarded children and normal children, matched for age and sex, using an immunological method. Higher levels of gammaG globulin were observed in patients with Down's syndrome, in association with a small but significant lower concentration of gammaM globulin. The titres of anti-A and anti-B agglutinins and antibodies to Escherichia coli, estimated before and after treatment of serum with 2-mercaptoethanol, were found to be within normal levels. These data seem to suggest that patients with Down's syndrome do not produce ;faulty' immunoglobulins as has been previously postulated. It is suggested that the abnormal levels of immunoglobulins found in Down's anomaly are not peculiar to patients with Down's syndrome but occur in other disorders in which the reticuloendothelial system or the lymphocytes are involved.


Results of a double staining method for DNA and RNA.


The surface structure of M. leprae.

The surface structure of M. leprae.


Protein pattern of cerebrospinal fluid in mental disease.


Intestinal antibodies to wheat fractions in celiac disease.


Immunohistology of the lung in Goodpasture's syndrome.


Mixed cryoglobulins and glomerulonephritis.


Preventing mental impairment. How can the pediatrician help?


Light chain types in pig antibodies to the 2,4-dinitrophenyl group.


Specific enzymatic and chemical hydrolysis of kininogen and kinin-yielding peptides.


Arterial insufficiency of the brain: progression prevented by long-term anticoagulant therapy in eleven patients.


Equine goiter due to excess dietary iodide.


Diagnosis, treatment, and control of vibriosis in an artificial insemination center.


Diagnostic aids--anterior segment of the eye.


Anaemia and L.E. cell phenomena in rheumatic and rheumatoid diseases.


Lipid fixation during preparation of chloroplasts for electron microscopy. Reaction of osmium tetroxide with isolated spinach chloroplasts fixed completely the glycolipids, phosphatidyl glycerol, and phosphatidyl choline. Under the same reaction conditions only 30% of the chlorophyll was fixed. Reaction of potassium permanganate with isolated spinach chloroplasts fixed more than 90% of the glycolipids, phosphatidyl glycerol, and phosphatidyl choline, provided the reaction period was long enough. Potassium permanganate also fixed the chlorophyll. Reaction of osmium tetroxide and potassium permanganate with isolated (14)C-lipids from Chlorella pyrenoidosa fixed 59% and 66% of the radioactivity, respectively. The lipids that were not fixed included sterols and pigments. Electron micrographs show that chloroplasts extracted with chloroform-methanol after fixation in osmium tetroxide or potassium permanganate differ from those dehydrated with acetone mainly in that in the former, osmiophilic globules have been removed and there seems to be some fusion of the boundary membranes and grana membranes. These effects may be due to the extraction of unfixed, neutral lipids such as sterols and quinones.


Rat assay of a simulated human diet for antithyrotoxic substances.


Scaling studies of phonetic symbolism.

Scaling studies of phonetic symbolism.


Comparative pharmacokinetics of coumarin anticoagulants. 3. Factors affecting the distribution and elimination of bishydroxycoumarin (BHC) in isolated liver perfusion studies.


Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination.


Effect of perfusion rate and distribution factors on drug elimination kinetics in a perfused organ system.


The multimedia approach to health instruction for prospective teachers.


Disinfection of lung ventilators.

Disinfection of lung ventilators.


Bone and marrow biopsy with saw-toothed modification of Vim-Silverman needle.


Experimental approach to the renewal of the skin surface.


Immune responses.

Immune responses.


Crystallographic data for the Fab fragment of a human myeloma immunoglobulin.


Other surface active agents for use with the PAF sedimentation technic for intestinal parasites.


The treatment of peripheral occlusive arterial disease with alpha-tocopherol as compared with vasodilator agents and antiprothrombin (dicumarol).


Demonstration of Histoplasma capsulatum in peripheral blood by the use of methenamine-silver nitrate stain (Grocott's).


Rapid measurement of erythrocyte carbonic anhydrase isozymes by means of cellulose acetate membrane electrophoresis.


Schistosomal phosphatases. Histochemical localization of alkaline and acid phosphatase in cercariae of Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum.


Effect of acute administration of acetysalicylic acid on the prothrombin activity of bishydroxycoumarin-treated rats.


Electrophoretic distribution of serum proteins of normal and an arthritic white-tailed deer (Odocoileus virginianus).


The relation between the severity of displacement of fractures and the variations in serum proteins.


Human reaginic antibodies and immunoglobulin E.


A new ADA service: patient-counseling films for use in the dental office.


Reduction of nonspecific background staining in the fluorescent treponemal antibody-absorption test. The nonspecific background fluorescence which occurs with the fluorescent treponemal antibody-absorption test for syphilis was found to result from a reaction between serum-treated Treponema pallidum organisms and the conjugated antihuman gamma-globulin. It was also shown that beta-lipoprotein and albumin were the important contributing factors in human serum. Various dilutions of 2.5% trypsin in phosphate-buffered saline specifically reduced background fluorescence under proper test conditions. By employing a trypsin digestion method, a semiautomated procedure utilizing a visual readout has been postulated as feasible.


Antibody response to Staphylococcus aureus in rabbits: sequence of immunoglobulin synthesis and its correlation with passive protection in mice. Antibody in hyperimmune rabbit antisera specific for Staphylococcus aureus teichoic acid was shown to be associated with the IgM fraction. Treatment of such sera with mercaptoethanol destroyed its activity in passive mouse protection tests, whereas absorption with antirabbit IgG had no effect. Antibody response in normal rabbits immunized by a single or by three daily injections of a killed vaccine of S. aureus was followed by a sensitive passive hemagglutination test. Antibody detected during the "primary" response was completely susceptible to reduction with mercaptoethanol. Most of the antibody detected after a secondary antigenic stimulation at 10 weeks was also susceptible to mercaptoethanol. The antibody titers correlated well with mouse protective activity, and this activity of the serum was also shown to be associated with the IgM fraction.


Lipid composition of the nervous system in Refsum's disease. The compositions of the major lipids and their constituent fatty acids and fatty aldehydes from cerebral gray matter, white matter, and myelin, spinal cord myelin, and sciatic nerve were determined in a 57 yr old woman who died of Refsum's disease. There were deficiencies of ethanolamine glycerophosphatides (EGP) in gray matter and frontal lobe myelin, and a lipid with the chromatographic properties of lyso-EGP accumulated in all tissues. The proportions of the remaining lipids were nearly normal in the central nervous system tissues. In the sciatic nerve the proportions of sphingolipids were small; this observation is consistent with the severe demyelination noted on pathologic examination. Cholesteryl esters were not detected in any tissue. Phytanate (3,7,11,15-tetramethylhexadecanoate) was present in the glycerophosphatides from each tissue. Higher proportions of phytanate were found in choline glycerophosphatides (CGP) than in EGP or in serine glycerophosphatides (SGP). Hydrolysis with phospholipase established that phytanate was confined to the 1-position of CGP. More phytanate was found in CGP from myelin than from gray or white matter. Fourfold higher proportions of phytanate were found in CGP from sciatic nerve than in CGP from the central nervous system: in sciatic nerve, 24% of the fatty acids of CGP consisted of phytanate. The proportions and compositions of sphingolipid hydroxy fatty acids and odd-numbered fatty acids were normal in each tissue. These findings argue against a defect in sphingolipid alpha-hydroxy acid metabolism in Refsum's disease. The results are consistent with the view that the accumulation of phytanate is responsible for the demyelination.


Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease. This study was made to determine the extent of absorption of chlorophyll phytol from the intestine of man, and the importance of chlorophyll as a source of the phytanic acid that accumulates in Refsum's disease. Uniformly (14)C-labeled pheophytin a (the Mg-free derivative of chlorophyll a) was fed to normal human subjects and to patients with Refsum's disease. Feces were collected and analyzed. In all subjects, 90-95% of the administered radioactivity was recovered in the feces, still largely in the form of pheophytin a. The phytol radioactivity recovered in the feces averaged about 95% of that in the administered material, which indicates that there had been little absorption of the phytol moiety. Similarly, after 250 g of cooked spinach had been fed to a normal subject, almost the entire phytol content was found in the feces. Less than 5% of the ingested spinach phytol was accounted for in the thoracic duct lymph of another subject. It was concluded that not more than about 5% of the ingested chlorophyll phytol is absorbed by man, whether normal or afflicted with Refsum's disease. On this basis we conclude that the major portion of the phytanic acid that accumulates in Refsum's disease could not be derived from dietary chlorophyll.


Effect of aminotriazole on thyroid function in the rat.


The cytology of inflammatory secretions of the colonic mucosa.


The functional significance of the presence of acid phosphatase at the nucleic-acid synthesizing sites in the nuclei of the neurons of the cephalothoracic ganglionic masses of palaemnius.


Structural and histochemical changes in the axons following nerve crush.


Iron content of Brunner's glands in acquired hemosiderosis.


Apical localization of glycoproteins in gastric mucous cells.


Histochemical patterns in single peripheral nerve fibers.


Cardiac surgery in neonates: a chance for life.


The Schultz--Dale reaction of the depolarized guinea-pig uterus. 1. The sensitized guinea-pig uterus contracted on addition of antigen (egg-albumin), even after it had been completely depolarized in an isotonic potassium sulphate solution.2. The contractile response of the depolarized preparation started at a later time after addition of the antigen, and had a smaller amplitude, than the Schultz-Dale contraction induced in the ordinary Ringer solution.3. A contracting substance was released from the depolarized uterus. The average histamine equivalent of this substance was 89% of the histamine concentration which reproduced the anaphylactic contraction and probably proportional to the mechanical response.4. The main component of the material released from the uterus in the ordinary Ringer was histamine. The material released from the depolarized uterus did not contain any demonstrable histamine activity.


Nursing the patient after heart surgery.


The presence of complement "bound" in vivo in the skin of patients with pemphigoid.


Histochemical observations in skin cancer, keratoacanthoma, and some other tumors of the skin.


Some hydrolases in the venomous gland of Cynips folii females.


The reaction of fatty acyl thiolesters with proteins.


Radiation therapy for rhabdomyosarcoma of the orbit.


a clinicopathologic report of 54 cases.

a clinicopathologic report of 54 cases.


Studies on the conformation of purified human and canine gamma-A-globulins and equine gamma-T-globulin by optical rotatory dispersion.


Molecular sieve studies of interacting protein systems. 3. Measurement of solute partitioning by direct ultraviolet scanning of gel columns.


Studies of cervical mucus and serum from infertile women.


Double-blind trial of a sequential oral contraceptive (Sequens) in the treatment of dysmenorrhoea.


Chlormadinone acetate as an oral contraceptive: clinical results and the incidence of ovulation.


Staining of immature collagen by resorcin-fuchsin in infant kidneys.


A technique for staining certain types of transparent particles, to facilitate size analysis by television scanning microscopy.


Investigation of staining, polarization and fluorescence-microscopic properties of pseudo-elastic fibres in the renal arterial system.


Serum protein values in newborn Egyptian infants.


Potassium, glucose, and insulin treatment for acute myocardial infarction.


Anticoagulants in "irreversible" acute renal failure.


Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome.


Prognosis of general paresis after treatment.


Immunological reconstitution of sex-linked lymphopenic immunological deficiency.


Mortality from Hodgkin's disease in the United States. Evidence for the multiple-aetiology hypothesis.


Design and use of plastic tents for isolation of patients prone to infection.


Human calcitonin.

Human calcitonin.


Assessment in rheumatoid arthritis.

Assessment in rheumatoid arthritis.


E. B. antibodies and infectious mononuleosis.


Delayed fertilisation.

Delayed fertilisation.


Too few neuropathologists.

Too few neuropathologists.


The Hong Kong-68 influenza A2 variant.

The Hong Kong-68 influenza A2 variant.


Menstruation and examinations.

Menstruation and examinations.


The duration of pregnancy.

The duration of pregnancy.


Hypercalcaemia and calcium resin.

Hypercalcaemia and calcium resin.


Premature feeding?

Premature feeding?


Urinary electrolytes in renal lithiasis.


Humidification of inspired air.

Humidification of inspired air.


Gastric iron-binding in haemochromatosis.


Alterations of fibrinolysis and blood coagulation.


Early detection of cancer.

Early detection of cancer.


Bradycardia in myocardial infarction.

Bradycardia in myocardial infarction.


Environmental temperature and death-rate from intestinal neoplasms.


Even more concentrated antihaemophilic globulin.


Hemolytic-uraemic syndrome.

Hemolytic-uraemic syndrome.


Hyposmia following laryngectomy.

Hyposmia following laryngectomy.


Abuse of "Filon".

Abuse of "Filon".


Inhibition of reagin-induced passive cutaneous anaphylaxis.


Preventing air-embolism after abdominal injury.


Methotrexate in psoriasis.

Methotrexate in psoriasis.


Alkaline phosphatase in liver cirrhosis and rectal cancer.


Beta-glucuronidase activity in cholestatic liver.


Feeding the newborn.

Feeding the newborn.


Autoallergy in pemphigus.

Autoallergy in pemphigus.


47-48 mosaicism in newborn with trisomy D.


Abuse of methylamphetamine.

Abuse of methylamphetamine.


Donald Hugh Paterson.

Donald Hugh Paterson.


Non-allelic nature of the basic sequences of normal immunoglobulin K chains.


Anaphylactic transfusion reactions associated with anti-IgA antibody.


Observations on the nature and significance of the long-acting thyroid stimulator.


Immmunosuppressive drugs in the treatment of autoimmune haemolytic anaemia.


The secretory activity and the cuticle of the corneal endothelium.


Carbon monoxide: analysis of exhaust gas investigations in Paris.


Air pollution.

Air pollution.


IgA and partial deletions of chromosome 18.


Leprous endocrinopathy.

Leprous endocrinopathy.


TRIC-agent neonatal conjunctivitis.

TRIC-agent neonatal conjunctivitis.


Urinary hydroxyproline and protein nutrition.


Electrolyte abnormalities and porphyria.


G.K.I. in acute myocardial infarction.

G.K.I. in acute myocardial infarction.


Blood potassium, glucose, and insulin in patients undergoing peritoneal dialysis and haemodialysis.


Antinuclear antibodies in cryoglobulinaemic diseases.


Micturating cystourethrography.

Micturating cystourethrography.


Adaptation to low-protein intakes.

Adaptation to low-protein intakes.


Serum-alkaline-phosphatase in cystic fibrosis of the pancreas.


Preservation of leucocytes for delayed counts.


Aortitis and ankylosing spondylitis.

Aortitis and ankylosing spondylitis.


Umbilical-cord IgM and amniotic infection.


Ignis sacer.

Ignis sacer.


Cellular and humoral responses to measles in subacute sclerosing panencephalitis.


Effect of anaesthesia on intracranial pressure in patients with space-occupying lesions.


Bacterial contamination of the upper small bowel in tropical sprue.


Transient and permanent deafness following treatment with ethacrynic acid in renal failure.


Acquired resistance to treatment with arvin.


Viral transformation of cells from persons at high risk of cancer.


Control of growth-hormone secretion in health and disease.


Youth and age in hospital medicine.

Youth and age in hospital medicine.


Another crisis.

Another crisis.


Cancer risk and viral transformation.

Cancer risk and viral transformation.


Measures of dementia and senile change.

Measures of dementia and senile change.


Priorities.

Priorities.


Accident and emergency services.

Accident and emergency services.


Buerger's disease reassessed.

Buerger's disease reassessed.


Outbreak of A2-Hong Kong-68 influenza at an international medical conference.


A coloured career-structure?

A coloured career-structure?


Total clearance of pelvic organs for carcinoma; nursing care study.


Thyroid adenocarcinoma: a functioning tumour.


Critical study of ribonucleic acid staining by gallocyanin-chromalum.


Biosynthesis of fatty acids in the larvae of the blowfly, Aldrichina grahami, reared aseptically.


Occurrence of arginase in the blowfly, Aldrichina grahami, and changes in its activity in the life cycle.


Contraction characteristics of papillary muscle during changes in acid-base composition of the bathing-fluid.


Changes in the ocntents of phosphatides and composition of their fatty acids in mung bean seedlings (Phaseolu auresu).


Force-frequency relationship of human atrial muscle in vitro: beta-adrenergic mechanisms.


Studies on regulatory aspects of nutrition at molecular level. I. Enzyme turnover during fasting.


Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods.


The effect of age on the variation of the phosphorus content in the muscle, liver adn brain of rats.


The extracellular space of the isolated intestinal epithelium of the Greek tortoise.


Effect of total-body x-irradiation on the properties of polyribosomes in normal rat liver.


Structural changes in mitochondria induced by uncoupling reagents. The response to snake-venom phospholipase A.


Acetyl disulfide, (CH3COS)2, a major active component in the thiolacetic acid histochemical method for acetylcholinesterase.


The preparation and properties of the membranal DPNH dehydrogenase from Escherichia coli.


Acetyl disulfide, (CH3COS)2, and bis-(thioacetoy) aurate (I) complex, Au(CH3CHOS)2,-histochemical substrates of unusual properties with acetylcholinesterase.


Fluctuations in the acid phosphatase activity of spherosomes in guard cells of Campanula periscifolia.


Selective staining of nervous tissue for light microscopy following preparation for electron microscopy.


Histochemistry of demyelination and myelination.


A rapid method for preparing tissue for light and electron microscopy.


Ultracentrifugal studies of the aggregation of human immunoglobulin G by freezing and by heating.


Primary biliary cirrhosis. Immunoglobulins in surgical appraisal.


Different susceptibilities of chick embryo liver cells in vitro to aflatoxin, actinomycin D, and mitomycin C.


Origin of arterial prosthesis lining from circulating blood cells.


The concept of autoimmunity.

The concept of autoimmunity.


Autoimmune disease in humans.

Autoimmune disease in humans.


Serological studies in autoimmune haemolytic anaemia.


Evidence of an auto-immune reaction i viral plasmacytosis (Aleutian disease) of mink as demonstrated by the Coombs test.


Haemolytic aneamia. The use of an animal model.


The chemical structure of immunoglobulins.


Gm genes and gamma G molecules.

Gm genes and gamma G molecules.


Immuno-globulin metabolism.

Immuno-globulin metabolism.


Prophylaxis and therapy with human immunoglobulin preparations.


In vitro lymphocyte changes in 24-hour cultures.


Cellular dynamics in lymph nodes and skin reactions.


Changes in the rates of synthesis of certain plasma proteins following tissue damage due to talc injection. A study using the perfused rat liver.


Immunofluorescent demonstration of staphylococcal leucocidin components F and S.


Polymorphonuclear cell fractions which stimulate increase on an acute phase protein in the rat.


Effect of bacterial flora on iron absorption in the rat.


Drug-induced autoimmune disease: haemolytic aneamia and lupus cells after treatment with methyldopa.


Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement. Two mechanisms have been described whereby rabbit platelets in vitro may be induced to release their contained histamine by the reaction of antigen and antibody. Both processes require the participation of the complement system. In the first, the adherence of platelets to particulate antigens such as zymosan or erythrocytes which have fixed complement through the third component was followed by histamine release. Plasma lacking C6 activity was fully active in this system. In the second mechanism, the reaction of soluble antigen with antibody in the presence of plasma also caused release of histamine from platelets and platelet clumping was observed. The release process, which appeared to follow the adherence of platelets to the immune complex, required the action of C6 and perhaps the later-acting components. No evidence could be obtained that a soluble factor was produced which caused the release. Instead, an inhibitor of the release process was detected after incubation of antigen, antibody, and plasma. Antibody preparations capable of giving complement-dependent PCA reactions in rabbits were also shown to induce the release of histamine from platelets in vitro.


Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice. Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.


Morphological lesions of intramuocarial arteries in 100 cases examined post mortem.


Contribution to the study of regenerative-degenerative qualities of the fasciculi optici in mammals under experimental conditions.


Development of the human nasopharyngeal epithelium.


Comparative histochemical studies on the development of teeth in man and in the mouse.


Allometric growth of the eye in the chick and the rat during ontogenetic development.


Pathological and biochemical study of metachromatic leucodystrophy.


Dextran plasma volume expanders: chemistry and biological activities.


Free immunoglobulin light chains in connective tissue diseases.


Rheumatoid pleurisy and pericarditis.

Rheumatoid pleurisy and pericarditis.


Immunoelectrophoresis of egg and plasma proteins during development of the house sparrow, Passer domesticus.


A "silent" phase of hypocomplementemic persistent nephritis detectable by reduced serum beta-1c-globulin levels.


Members of Pennsylvania Dental Association.


Studies on the immunoglobulins.

Studies on the immunoglobulins.


Haemolytic anaemia in a patient taking thioacetazone.


Corneal grafting and the nursing management.


Intraoperative cytodiagnosis.

Intraoperative cytodiagnosis.


A postmortem study of cerebrospinal fluid with histologic correlation.


An evaluation of a simplified technique for colonic exfoliative cytology.


Surface phenomena of the tear film.

Surface phenomena of the tear film.


Comparison of the 125T-3 and 125T-4 tests in the diagnosis of thyroid gland function in the dog.


Ocular pathology of diabetes mellitus.

Ocular pathology of diabetes mellitus.


Mode of action of a gastric-secretion antagonist.


Some pharmacodynamic properties of cellulose sulphate, a kininogen-depleting agent in the rat.


Infectious peritonitis in cats.

Infectious peritonitis in cats.


Electron microscopic study of polyoma-induced salivary gland tumors, with special reference to cell-virus interactions.


Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Cocarcinogenes by cyclopropenoid fatty acids and the effect of gossypol and altered lipids on aflatoxin-induced liver cancer.


Replication of a genophore during sucessive cell division cycles in Escherichia coli K-12, synchronized with cold-shock.


DNA synthesis and genophore replication in Escherichia coli K-12 synchronized with thymine starvation.


Investigations on the variability of pathogenicity of Newcastle diasese virus (NVD). VI. Influence of chick-embryo incubation temperature.


Germination anomaly in spores of streptomycin dependent Bacillus substilis.


ATP-ase activity of membrane fragments of Streptococcus haemolyticus.


Acid phosphatase activity of exudative cells of peritoneal cavity of guinea pigs infected with tubercle and BCG bacilli.


Studies on versicolin, a new antifungal antibiotic from Aspergillus versicolor. 3. Relationship between antibiotic synthesis and basic cellular metabolism.


The occurrence of Azotobacter spp. in soils from monocultures of rye and potatoes.


Further studies on the staining of tubercle bacilli.


On the mechanism of ultraviolet-light action on Escherichia coli recombination.


Genetics of citric acid producinig strains of Aspergillus niger. I. Citric acid synthesis by morphological mutants induced iwth UV.


Hemorrhagic reactions in the hamster produced by interaction of protein A from Staphylococcus aureus human gamma-globulin and endotoxin.


Influence of antirheumatic agents on the release of histamine from sensitized rat peritoneal mast cells. II. Antibody production.


Whipple's disease and papilledema. An unreported presentation.


Effect of immunosuppressive therapy for renal transplantation in man on marrow and blood.


Silver staining of nerve endings in human digital glabrous skin.


A histochemical study of the mucins of te adult human nasopharynx.


Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins.


Identification of the A protein as a structural component of bacteriophage R17.


Localized amyloidosis of the urethra: report of a case.


Medical treatment of benign nodular prostatic hyperplasia with cyproterone acetate.


Blood loss during transurethral prostatectomy.


Long-term effects of oral contraceptives on the ovary and pituitary.


A method for staining centrosomes on cytological smears.


Long-term contraceptive effect of injectable progestogens: inhibition and reestabilishment of fertility. The antifertility effect of long-acting injectable progestogens was evaluated in 2,000 young, fertile women observed during 34,800 woman-months.  Depo-medroxyprogesterone (Depo-MPA) was injected intramuscularly every 6 months in 1,580 women.  The compound was used at different dosages, for a total of 30,900 months.  There was a total incidence of 2.72 pregnancies per 100 woman-years.  Injectable chlormadinone acetate was given every 3 months, 100 mg intramuscularly.  This dosage seemed inadequate, since a total of 25.5 pregnancies per 100 woman-years occurred in 1600 months observations.  Injectable norethisterone enanthate, 200 mg, was administered to 130 women every 3 months.  In 2300 months of observation, there was a total incidence of 9.4 pregnancies per 100 woman-years.  In most subjects, fertilization occurred promptly upon abandoning the method;  however, from 7 to 18 months were required when depo-mpa was used.  In subjects wishing to become pregnant sooner, ovulation was induced with clomiphene citrate and human chorionic gonadotropin.  Histologic and histochemical observations in ovarian tissue obtained by biopsy demonstrated development of follicles up to the graafian stage.


Intracapsular prostatic resection.

Intracapsular prostatic resection.


On the mechanism of action of delta-HCH (hexachlorocyclohexan) in fungi.


Astrocytic neuroglial cells, oligodendrocytes and microgliacytes in the spinal cord of the toad. I. Light microscopy.


Transfer of 14C-thiouracil during pregnancy.


Treatment of advanced endometrial carcinoma with a progestational agent.


Cervical carcinoma. Metastases to the solar region.


Alizarin red in the study of the apposition and resorption on bone.


Alizarin and tetracycline binding by bone mineral.


Tetracycline bone labeling in anatomy.

Tetracycline bone labeling in anatomy.


Lead acetate as a vital marker for the analysis of bone growth.


Chloro-s-triazines as markers and fixatives for the study of growth in teeth and bones.


Procion dyes as matrix markers in growing bone and teeth.


Normal craniofacial skeletal growth of the rat.


The influence of different types of early treatment on the prognosis of severe burns.


Distribution and losses of plasma proteins during the early stage of severe burns.


Bullous pemphigoid associated with systemic lupus erythematosus.


Scleromyxedema. A dramatic response to melphalan.


Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjögren's syndrome.


Formation of yeast mitochondria. I. Kinetics of amino acid incorporation during derepression.


Punctate keratopathy of West Indians.

Punctate keratopathy of West Indians.


Undescribed endothelial processes of the choriocapillaris extending to the retinal pigment epithelium of the chick.


Alleviatiin of dietary cirrhosis with betaine and other lipotropic agents.


Rubella and pregnancy.

Rubella and pregnancy.


Immunoglobulin D in serum, body fluids and lymphoid tissues.


Studies into the occurrence of soluble antigen--antibody complexes in disease. I. A biological assay for soluble complexes.


Studies into the occurrence of soluble antigen-antibody complexes in disease. 3. Rheumatoid arthritis and other human diseases.


Studies into the occurrence of soluble antigen-antibody complexes in disease. II. Criteria for distinguishing soluble complexes from other macromolecular histamine releasers.


Immunological aspects of Goodpasture's syndrome.


Carcinoma of the male breast: a reappraisal.


A natural RNA-DNA complex in bacterial cells.


BCG vaccination against mycobacterium ulcerans infection (Buruli ulcer). First results of a trial in Uganda.


Effect of prednisone on the survival of patients with cirrhosis of the liver. A report from the Copenhagen Study Group for Liver Diseases.


Excessive urinary excretion of certain porphyrinogenic steroids in human acute intermittent porphyria.


Comparison of efficacy of 3 and 12 months' anticoagulant therapy after myocardial infarction. A controlled clinical trial.


Myokymia with impaired muscular relaxation.


A critical appraisal of a method fo estimating urinary 17-oxosteroids and total 17-oxogenic steroids. A memorandum prepared at the request of the clinical Endocrinology Committee of the Medical Research Council.


Action of antilymphocytic sera on reactions caused by immune-complex formation.


A heated ultra-high-efficiency filter for mechanical ventilators.


Cannabis.

Cannabis.


Mechanisms of memory.

Mechanisms of memory.


Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect.


Vomiting.

Vomiting.


Infection in hospital.

Infection in hospital.


Dental inertia.

Dental inertia.


A computer-assisted system for learning clinical diagnosis.


Some hospital admissions associated with cannabis.


Early detection of cancer.

Early detection of cancer.


Evaluating drug trials unseen.

Evaluating drug trials unseen.


Fatal "lomotil" poisoning.

Fatal "lomotil" poisoning.


Lysergide and cannabis as possible teratogens in man.


Phenazopyridine-hydrochloride haemolysis.


Natural history of aortic stenosis.

Natural history of aortic stenosis.


Renal transplantation.

Renal transplantation.


Examination of clinical examiners.

Examination of clinical examiners.


Plasmapheresis in hepatic coma.

Plasmapheresis in hepatic coma.


Cerebral metabolism after portacaval shunt.


Analysis of psychiatric diagnosis.

Analysis of psychiatric diagnosis.


Cutting out tonsillectomy.

Cutting out tonsillectomy.


Significance of adrenergic innervation of the bladder outlet during ejaculation.


YY-syndrome forms.

YY-syndrome forms.


Urinary magnesium and renal stones.

Urinary magnesium and renal stones.


The polydactyly--imperforate-anus--vertebral-anomalies syndrome.


Premature menopause in autoimmune diseases.


Nitroblue-tetrazolium test in children with fatal granulomatous disease and newborn infants.


YY syndrome and sampling techniques.

YY syndrome and sampling techniques.


Human calcitonin.

Human calcitonin.


51Cr Excretion in bile.

51Cr Excretion in bile.


Adrenal cortex and post-hepatic syndrome.


Interplay of vibrio cholerae strains in Calcutta.


Combined and sequential oral contraceptives and progesterone.


Flying into a breech.

Flying into a breech.


Immunoglobulin assembly in a mouse myeloma.


Influence of age and hypertension on splenic hyaline arterioscerosis.


Staining conditions influencing morphological index of acid-fast bacilli.


Neuron staining by basic dyes versus basic metal-dye complexes: differences shown by histochemial blocking reactions.


Combination of Gomori and Ziehl-Neelsen stains for showing acid phosphatase activity and Mycobacterium tuberculosis in macrophages.


The selective staining of curous bodies in lymph nodes of patients as a means for diagnosis of sarcoid.


Stainng plant cell nucleoli with AgNO3 after formalin-hydroquinone fixation.


A method for immunocytochemical study of human gastrointestinal suction biopsies.


Hematoxylin staining of tissue embedded in epoxy resins.


Modification of the Bodian technique applied to insect nerves.


Deteriorated paraldehyde: an insidious cause of failure in aldehyde-fuchsin staining.


Staining mitochondria in Saccharomyces cerevisiae.


Observations on the caudate nucleus of the cat impregnated with the Golgi method.


Detection of multiple forms of proteolytic enzymes by starch gel electrophoresis.


Developmental phases in intermitosis and the preparation for mitosis of mammalian cells in vitro.


The cellular immune response of nonhuman primates to crude type 2 cholera toxin.


Detection of complex carbohydrates in the Golgi apparatus of rat cells. Two methods used for the electron microscopic detection of glycoproteins were applied to a variety of cell types in the rat; one involved successive treatment of sections with periodic acid, chromic acid, and silver methenamine; and the other, a brief treatment with a chromic acid-phosphotungstic acid mixture. The results obtained with the two methods were identical and, whenever the comparison was possible, similar to those obtained with the periodic acid-Schiff technique of light microscopy. In secretory as well as in nonsecretory cells, parts of the Golgi apparatus are stained. The last saccule on one side of each Golgi stack is strongly reactive (mature face), and the last saccule on the other side shows little or no reactivity (immature face); a gradient of reactivity occurs in between these saccules. The more likely explanation of the increase in staining intensity is that carbohydrate is synthesized and accumulates in saccules as they migrate toward the mature face. In many secretory cells, the mature face is associated with strongly stained secretory granules. Other structures stained are: (1) small vesicles, dense and multivesicular bodies, at least some of which are presumed to be lysosomal in nature; (2) cell coat; and (3) basement membrane. The evidence suggests that the Golgi saccules provide glycoproteins not only for secretion, but also for the needs of the lysosomal system as well as for incorporation into the cell coat and perhaps basement membrane.


Aleutian disease of mink: properties of the etiologic agent and the host responses.


Interactions between keratinocytes and dendritic cells.


Intralabyrinthine perfusion.

Intralabyrinthine perfusion.


Pharmacology of venoms--introductory remarks.


Mechanism of histamine release by animal venoms.


Promoting audio-visual aids.

Promoting audio-visual aids.


Iodine metabolism in endemic goitre in countries of the Middle East. 3. On the pathogenesis of simple goitre.


Chronic pulmonary artery occlusion with a silastic transvenous balloon catheter.


The nature and significance of the long-acting thyroid stimulator.


The Bangkok variant of the serum group-specific component (Gc) and the frequency of the Gc alleles in Thailand.


Thyroid--adrenocortical responses to anaesthesia in man.


Editorial.

Editorial.


Nerve cells in the extracranial portion of the hypoglossal nerve in human fetuses.


Ammonium interations with proteins.

Ammonium interations with proteins.


The heterogeneity of human immunoglobulins.


An audio-visual teaching unit for dermatology.


Quantitative estimation of immunoglobulins and other serum proteins by immunological methods.


Comments on quantitative estimation of immunoglobulins and other serum proteins by immunological methods.


Structure of immunoglobulins.

Structure of immunoglobulins.


Pathology of immunoglobulins. Some aspects of monoclonal gammopathy.


Specificity of the immune response to the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl groups. Ligand binding and fluorescence properties of cross-reacting antibodies. THE PRINCIPAL RESULTS OF THE PRESENT STUDY ARE: (a) the failure to find an antibody subset that binds a cross-reacting ligand better than the comparable homologue in spite of the use of isolation methods that select for such antibody molecules; (b) the isolation of antibody subsets with virtually indistinguishable average intrinsic association constants for homologous and cross-reacting ligands, but which nevertheless have physical properties (Qmax and relative fluorescence coefficient) that readily distinguish these subsets according to their origin in response to antigenic stimulation with DNP- or with TNP-protein; (c) the demonstration, by precipitin reaction and measurement of association constants for homologous and cross-reacting haptens, of generally greater cross-reactivity among high affinity anti-DNP and anti-TNP antibodies, i.e. low affinity antibodies are generally more discriminating; (d) the selection of anti-DNP and anti-TNP antibody subsets that are distinctive in their ability to show spur formation in gel diffusion reactions with homologous and cross-reacting antigens. These results suggest that in the initial cellular response to antigenic stimulation, DNP-BgammaG and TNP-BgammaG stimulate virtually nonoverlapping sets of antigen-sensitive cells, despite the great similarity of these two immunogens. With prolonged stimulation this specificity wanes, giving rise to a more degenerate response evident in the greater cross-reactivity of the antibodies produced later in immunization.


Cephalic and pharyngeal structures in microfilariae revealed by staining.


A quantitative study of the stimulation of DNA synthesis in lymph node cell cultures by anti-lymphocyte serum, anti-gamma globulin serum, specific antigen, and phytohemagglutinin. Rabbit anti-guinea pig lymphocyte serum is an efficient stimulus of the synthesis of DNA by guinea pig lymph node cells in vitro. The ability of ALS to stimulate lymphocytes is characterized by its lack of dependence on prior sensitization, the magnitude of the response it elicits, and the stimulation of all sensitive lymph node cells simultaneously within a very narrow range of ALS concentrations. In contrast to this homogeneous response to ALS, the stimulation of lymph node cells by antigen proceeds in graded fashion over a wide range of concentrations, thus reflecting the heterogeneity of the response of sensitized cells to antigen. PHA gives a response which is intermediate between that of ALS and antigen. ALS appears to have specificity for membrane determinants shared by lymphocytes but not found on other tissues. This specificity does not involve cell-bound gamma globulin. The serum activity mediating lymphocyte stimulation as well as cytotoxicity is readily removed by absorption with lymph node cells.


The human secretory immunoglobulin system: immunohistoligical localization of gamma A, secretory "piece," and lactoferrin in normal human tissues. The immunohistological localization of gammaA, secretory "piece" (SP), and lactoferrin (LF) in the mucosae of a variety of normal human tissues was investigated using specific fluoresceinated antisera. gammaA staining was localized in the apical portion of the mucosal epithelium, intercellular spaces, basement membrane area, and plasma cells of the interstitium or lamina propria of a number of normal human tissues. SP was ubiquitous in the mucosal epithelium of all tissues studied which included parotid and submaxillary glands, bronchi, pancreas, GI tract, sweat glands, kidney, and gall bladder. In addition, SP staining was localized in the intercellular spaces and on the surface of the epithelial cells lining the lumen of the secretory glands. No SP staining was observed in the plasma cells of the interstitium or lamina propria surrounding the secretory glands in these tissues, and no SP staining was observed in sections of normal spleen or lymph node tissue. SP staining was observed in the sweat glands, pancreas, and kidney in the absence of gammaA staining. LF was much less ubiquitous in the epithelial cells of the various tissues studied and appeared to be restricted primarily to the acinar epithelium of the bronchial mucosae, parotid, and submaxillary salivary glands, and was also found in renal tubular cells. A hypothetical model for the transport of gammaA and SP across mucosal membrane epithelium is presented.


An experience in preparing programmed instructional material in nursing.


New frontiers in orthodontics.

New frontiers in orthodontics.


The surgical attack in invasive bladder cancer.


Immunology of pregnancy: significance of blood group incompatibility between mother and foetus.


The ichthyosiform dermatoses.

The ichthyosiform dermatoses.


Milk proteins.

Milk proteins.


Studies of serum long-acting thyroid stimulator (LATS) in relation to exophthalmos after therapy for thyrotoxicosis.


Serum lipoproteins.

Serum lipoproteins.


The prevention of Rhesus haemolytic disease.


Experimental Rh immunization and immunosuppression by passive antibody; a survey of experimental programs in Rh negative volunteers.


Clinical evaluation of Rh immunoglobulin in the prophylaxis of immunization to the Rh factor.


The timing of sensitisation and its relevance to the prevention of Rh-haemolytic disease.


Prevention of Rh isoimmunization with anti-Rh gamma G globulin clinical trial on mothers.


The pathogenesis and prevention of Rh immunization in pregnancy.


Rh immunisation.

Rh immunisation.


Community air quality guides. Aldehydes.


Specificity of human anti-gamma-globulin factors for heavy chain subgroup determinants and autologous gamma-globulin fragments.


Diagnostic paraprotein in papular mucinosis.


Immunoglobulin levels in blood bank donors of a tropical country.


Tolerance of intravenous gamma globulin.


A comparison of neutralising antibodies to rubella virus in gamma-globulin and 'convalescent' sera.


Localization of the immunoglobulin factors Gm (a).(b) and Gm(x) in lymphoid tissue obtained from melanesian subjects of Gm-ab-ab and Gm-ax-ab phenotype.


The function of the eosinophil.

The function of the eosinophil.


African ethnopsychiatry in the field.

African ethnopsychiatry in the field.


Direct immunodiffusion technique for Ig quantitation.


Polyacrylamide gels of increasing concentration gradient for the electrophoresis of lipoproteins.


Phytanic acid in tissue lipids in Refsum's disease.


Screening method for detection of specific aminoacidemias.


Autoimmune haemolytic anaemias. I. Serological studies with pure anti-immunoglobulin reagents.


Quantitative distribution of human thyroglobulin autoantibodies in different immunoglobulin classes.


Purification of cold agglutinins from patients with chronic cold haemagglutinin disease. Evidence of their homogeneity from starch gel electrophoresis of isolated light chains.


Characterization and development in tissue cells of a virus of transmissible gastroenteritis of swine.


Some properties of a testosterone-binding component of human pregnancy serum.


The mutational alteration of the primary structure of yeast iso-1-cytochrome c.


Effects of iodine-131 thyroid damage on lactation and thyroid function in the bovine.


Accelerated maturation and persistent growth impairment in the rat resulting from thyroxine administration in the neonatal period.


Do-it-yourself spot announcements and candid film make successful safety week.


Dialysis as a tool in the study of erythropoietin.


A germfree infant.

A germfree infant.


Penetration of gown material by organisms from the surgeon's body.


Suppression of pancreatic glucagon release by the hypoglycaemic sulphonylureas.


Successful renal allotransplantation in presence of lymphocytotoxic antibodies. Importance of preoperative cross-matching.


Determination of faecal blood-loss after combined alcohol and sodium-acetylsalicylate intake.


Neoplasia and the coeliac syndrome in adults.


Pituitary-gonadotrophic function in Turner's syndrome.


Adrenocorticotrophic responses to a single injection of tetracosactrin depot and to a standard tetracosactrin infusion.


Serological diagnosis of idiopathic Addison's disease in patients on prolonged prednisolone therapy for steatorrhoea.


Treatment of hydrocephalus.

Treatment of hydrocephalus.


B.C.G. and the tuberculin test.

B.C.G. and the tuberculin test.


Progress at Southampton.

Progress at Southampton.


CBW.

CBW.


Histocompatibility differences and cancer.


Hunting the carrier.

Hunting the carrier.


Aspirin, alcohol, and gastric haemorrhage.


B.M.A. and the green-paper.

B.M.A. and the green-paper.


Possible role for dietary leucine in the pathogenesis of pellagra.


Pay scales for clinical teachers.

Pay scales for clinical teachers.


Cost of treatment of addiction.

Cost of treatment of addiction.


Shortage of chemical pathologists.

Shortage of chemical pathologists.


Buerger's disease reassessed.

Buerger's disease reassessed.


Emotional problems in a chronic dialysis unit.


In-vitro tests of antilymphocyte sera.

In-vitro tests of antilymphocyte sera.


Early detection of cancer.

Early detection of cancer.


Alpha-adrenergic receptors in human omentum?


Alcoholism in industry and family.

Alcoholism in industry and family.


Slides black and slides blue.

Slides black and slides blue.


Growth-hormone release and venepuncture.


Epidemiology and the Green-Paper.

Epidemiology and the Green-Paper.


The professional epidemiologist.

The professional epidemiologist.


Marking multiple-choice questions.

Marking multiple-choice questions.


Cutting out tonsillectomy.

Cutting out tonsillectomy.


Electrokinetic mobility of blood-platelets.


IgA and abnormal chromosome 18.

IgA and abnormal chromosome 18.


Folic acid and anticonvulsants.

Folic acid and anticonvulsants.


A coloured career-structure?

A coloured career-structure?


Ammonia nitrogen in "small-for-dates" newborn babies.


Mediastinal emphysema and mucocutaneous syndrome.


L.A.P. isoenzymes in neonatal hepatitis and biliary atresia.


Anticoagulants in cardiac infarction.

Anticoagulants in cardiac infarction.


Robert Leech Newell.

Robert Leech Newell.


David Thomson.

David Thomson.


William Hedley Jones.

William Hedley Jones.


Inhibition of the thyroid-stimulating globulin (LATS) by particulate and soluble cell fractions.


Histological, histochemical, and cytological observations on the adrenal gland of the wild white-footed mouse, Peromyscus leucopus.


Studies in female homosexuality. IV. Social and psychiatric aspects.


Schizophrenia-like psychosis in thyroid crisis.


Diabetes mellitus and prostatic hyperplasia.


Intrinsic neuronal organization of the vestibular nuclear complex in the cat. A Golgi study.


A unique class of rabbit immunoglobulins eliciting passive cutaneous anaphylaxis in homologous skin.


The effect of iodination on the precipitin reaction. The anti-p-azophenyltrimethylammonium (anti-AP) hapten system.


The prevention of rhesus immunization.

The prevention of rhesus immunization.


Structures of the lymph node and their possible function during the immune response.


Further investigations on the gammaglobulin content of human silicotic lesions using immunofluorescence.


Human heart transplantation.

Human heart transplantation.


Effect of temperature on it situ Feulgen reaction with Schiff reagent at less acid pH.


The nature of the iodinophilous vacuole of myxosporidan spores, and a proposal to synonymize the genus Myxosoma Thélohan, 1892 with the genus Myxobolus Bütschli, 1882.


Ice application to induce voiding.

Ice application to induce voiding.


Adrenaline induced acceleration of histamine formation in vitro, studied by two isotopic methods.


Aspects of Rh incompatibility.

Aspects of Rh incompatibility.


Refsum's disease and a related disorder.


Surgical relief of intractable pain due to cancer.


Alterations of iodine metabolism in asymptomatic thyroiditis.


In-vitro binding of histologic stains by collagen.


Aspects of fat metabolism in anorexia nervosa.


Detection of plasmodia by acridine orange stain.


Glomerular lesions induced in Pekin ducks by dietary administration of dimethylnitrosamine.


Experimental autoimmune nephrosis in rats. Morphogenesis of the glomerular lesion: immunohistochemical and electron microscopic studies.


Coumadin induced small bowel obstruction: report of a case.


The pathology of Trypanosoma siniae infection in pigs.


Comparative studies on the pathology and host physiology of malarias. IV. Serum protein alterations in Plasmodium coatneyi malaria: A comparison of cellulose acetate and polyacrylamide disc electrophoretic patterns.


Parasitological studies in British Honduras. 3. Some coccidial parasites of mammals.


Studies on the role of histamine and serotonin in graft rejection.


Determination of beta 1c globulin in the blood serum of children with diseases of the kidneys.


Purification of estradiol receptor from rat uterus and blockade of its estrogen-binding function by specific antibody.


The air transport of lead compounds present in automobile exhause gases.


Adrenocortical insufficiency in spite of high corticosteroid excretion in a patient with thyrotoxicosis.


Adverse reactions following administration of human gamma globulin.


Induction of inflammation, fever, and acceleration of adjuvant-disease by surfactants.


Separation of lactate dehydrogenase osozymes by paper electrophoresis.


The prophylactic antiarrhythimic effect of quindine in myocardial infarction. A controlled clinical trial.


Staining of fungal hyphae in tissue sections.


Bound coagulase or clumping factor. An investigation into its nature by means of selective destruction and a comparison with soluble coagulase.


Automatic slide staining in clinical bacteriology.


Hemodynamic correction of transposition of the great vessels in infants.


Radioimmunoassay determination of plasma-renin activity.


Eye examinations in patients taking oral contraceptives.


Serum-bile-acids in the stagnant-loop syndrome.


Platelet adhesiveness in postoperative deep-vein thrombosis.


Clinical application of serum-total-thyroxine estimation, resin uptake, and free-thyroxine index.


Treatment of Moloney lymphoma with lethal doses of dimethyl-myleran combined with injections of haemopoietic cells.


The glycogen content of human ectocervical tissue of females receiving steroid contraceptive therapy.


Endemic goitre in Sudan.

Endemic goitre in Sudan.


Structures associated with leptospires possibly relevant to the Marburg agent.


Renin and angiotensin as a mechanism of diuretic-induced antidiuresis in diabetes insipidus.


The Signed-Rank (Wilcoxon) test in the rapid analysis of biological data.


Graft treatment of immunity deficiency.

Graft treatment of immunity deficiency.


Drifting or navigation?

Drifting or navigation?


Cannabis continued.

Cannabis continued.


Resistant falciparum malaria.

Resistant falciparum malaria.


Hypertension in the African.

Hypertension in the African.


Continuous chemotherapy in the prevention of recurrent bacteriuria.


Where are the teachers of community medicine?


Establishment of a cholera treatment unit under epidemic conditions in a developing country.


Earnings-related social security.

Earnings-related social security.


Pay scales for clinical teachers.

Pay scales for clinical teachers.


Royal Commission on Medical Education.

Royal Commission on Medical Education.


Urinary steroid estimations.

Urinary steroid estimations.


Diagnosing brucellosis.

Diagnosing brucellosis.


Renal allotransplantation in presence of lymphocytotoxic antibodies.


Oral contraceptives and the urethral syndrome.


Metabolic changes in depression.

Metabolic changes in depression.


Adrenocortical function in mental illness.


Trisomy after colchicine therapy.

Trisomy after colchicine therapy.


Iron binding by gastric juice.

Iron binding by gastric juice.


Treatment of thyrotoxicosis.

Treatment of thyrotoxicosis.


Detecting hypothyroidism.

Detecting hypothyroidism.


B.M.A. and the-Green-Paper.

B.M.A. and the-Green-Paper.


Bradyarrythmia in myocardial infarction.


Alterations of fibrinolysis and blood coagulation.


Blood-potassium in patients undergoing haemodialysis.


Acute coronary heart-disease.

Acute coronary heart-disease.


Measurement of glomerular filtration-rate.


Ipecac syrup for poisoned children.

Ipecac syrup for poisoned children.


Serum-aminopherase levels in aortic dissection.


Early detection of cancer.

Early detection of cancer.


Skin reactions in cancer chemotherapy.

Skin reactions in cancer chemotherapy.


Clofibrate and the fibrinolytic system.

Clofibrate and the fibrinolytic system.


Clofibrate and the fibrinolytic system. (2).


Premature menopause in autoimmune diseases.


Effector mechanisms in immunity.

Effector mechanisms in immunity.


Maldistribution anaemia?

Maldistribution anaemia?


Phenacetin.

Phenacetin.


Anatomical aspects of transplant lung.

Anatomical aspects of transplant lung.


Laboratory data and diagnosis.

Laboratory data and diagnosis.


Action of phenobarbitone in preeclampsia.


Anaesthetic deaths and the sickle-cell trait.


Advisory Committee's Report on Cannabis.


Production, biological and therapeutic properties of some individual actinomycins.


Modification of Parkinsonism--chronic treatment with L-dopa.


Anti-Rh globulin in Massachusetts.

Anti-Rh globulin in Massachusetts.


Some host responses to nematode infections.


Surgical palliation in complete transposition of the great vessels: experience with the Edwards procedure.


Discontinuous electrophoresis on polyacrylamide gel slab.


Chemotherapy of malignant renal tumors.

Chemotherapy of malignant renal tumors.


Retention of health information.

Retention of health information.


Neuropathologic changes in a case of sulfite oxidase deficiency.


Electron microscopic structure of the "inclusion bodies" in Pick's disease.


Problems of the physically handicapped. 3. Getting beneath the surface.


A child suffering from intussusception.

A child suffering from intussusception.


The phagocytic function of the reticuloendothelial system in rats treated with Polybrene, Liquoid and compound 48/80.


Serologic tests in rheumatic diseases.

Serologic tests in rheumatic diseases.


Alteration of drug metabolism in rats and mice by an environment of cedarwood.


Microtubules in brain homogenates.

Microtubules in brain homogenates. Microtubules from neurons are preserved in homogenates of mammalian brain by medium containing organic solvents at acidic pH. By means of negative staining and electron microscopy, the relative concentration of microtubules in suspensions can be assayed. Microtubules from brain have a filamentous and substructure.


The use of cronolone-impregnated pessaries in two goats.


Peptide antibiotics.

Peptide antibiotics.


An autoradiographic study on metabolism of serotonin in cerebral nerve cells using 5-hydroxytryptophan-C14.


Fatal granulomatous disease.

Fatal granulomatous disease.


Wiskott-Aldrich syndrome. A study of 6 cases with determination of the immunoglobulins A, D, G, M and ND.


Secretory immunoglobulins.

Secretory immunoglobulins.


As I see it: O. R. education.

As I see it: O. R. education.


Myasthenia gravis, autoimmunity and the thymus.


Surgical suite and team nursing are compatible.


The disappearing OR nurse.

The disappearing OR nurse.


Will the OR nurse be needed in the future?


Testing your legal I. Q.

Testing your legal I. Q.


Continuity of care in cardiac surgery.

Continuity of care in cardiac surgery.


Beta-10-globulin and complement in nephritis. Serological and immunohistological studies in acute, chronic, membranous and lupus glomerulonephritis.


Liberation of pharmacologically active substances from mast cells by animal venoms.


Some physiological and immunological factors in inhibition of gastric secretion and natural history of gastric atrophic lesions.


A teaching plan for cardiac surgical patients.


Effect of administration of a combined estrogen-progestin contraceptive on the level of individual plasma proteins.


Carbamylated human immunoglobulins tested by electrophoresis in agarose and antibody containing agarose.


Postoperative cardiac nursing research: a method for identifying and categorizing nursing action.


Assay of protein-quinone coupling involving compounds structurally related to the active principle of poison ivy.


Gel electrophoresis destaining apparatus.


Polyacrylamide gel electrophoresis in a continuous molecular sieve gradient.


A new procedure for the palliation of transposition of the great vessels. An experimental study.


A simple procedure for the fractionation of the tryptic peptides of the C-terminal half of immunoglobulin lambda-chains.


The peripheral sensory pathway in friedreich's ataxia. An examination by light and electron microscopy of the posterior nerve roots, posterior root ganglia, and peripheral sensory nerves in cases of friedreich's ataxia.


Thiacetazone-isoniazid combination in the treatment of pulmonary tuberculosus.


Metabolic control mechanisms in mammalian systems. Hormonal regulation of phosphofructokinase in the rat prostate and seminal vesicles. 1. The hormonal regulation of phosphofructokinase was investigated in the accessory reproductive organs of the orchidectomized rat. 2. Phosphofructokinase activities declined to 51% and 47% in the prostate and 9% and 6% of the normal values in seminal vesicles 4 and 8 weeks after castration respectively. Administration of testosterone (100mug./100g. body wt.) for 3 days reversed substantially the effects of orchidectomy, and phosphofructokinase activity increased to 173% in the prostate and 536% in seminal vesicles as compared with the values of castrated controls. 3. Time-course studies demonstrated that after a single injection of testosterone (5mg./100g. body wt.) phosphofructokinase activity was maximally elevated to 236% in the prostate and 342% in seminal vesicles at 24hr. 4. Dose-response studies revealed that 2.5mg. of testosterone propionate/100g. body wt. was the minimal amount necessary to induce significant increases in enzyme activity in both accessory sex organs; maximal increases were obtained with a dose of 5mg./100g. body wt. 5. The observed enzyme increases induced by testosterone were inhibited by the simultaneous administration of oestradiol-17beta, and phosphofructokinase activity in this group of rats remained at 97% in the prostate and 137% of the control values in seminal vesicles. Oestradiol-17beta by itself failed to produce any significant effect on enzyme activity in either of these secondary sexual tissues. 6. The nature of the testosterone-induced increases in phosphofructokinase activity was studied by using a variety of inhibitors of RNA and protein synthesis. Cycloheximide, 5-fluorouracil and ethionine largely blocked the androgen-stimulated rise in enzyme activity observed 24hr. after steroid injection. The inhibitory effect of ethionine was completely reversed by the simultaneous administration of methionine. 7. Actinomycin, which is known to inhibit the synthesis of messenger RNA as well as the synthesis of other cellular RNA fractions, when given simultaneously with the hormone, also inhibited the testosterone-induced increases in prostatic and seminal-vesicular phosphofructokinase. However, when the antibiotic was given 6 or 12hr. after injection of the steroid, practically no inhibition of phosphofructokinase induction was obtained. This indicates that, once the enzyme-forming machinery is turned on and allowed to operate for a few hours, actinomycin is incapable of reversing the hormone-induced enzyme responses. 8. The results presented suggest that new RNA and protein synthesis may be involved in the observed androgen-induced increases in phosphofructokinase activity in the prostate and seminal vesicles of the orchidectomized rat.


Maternal and congenital rubella before 1964: frequency, clinical features, and search for isoimmune phenomena.


Cytochemistry of sea urchin gametes. II. Ruthenium red staining of gamete membranes of sea urchins.


A comparison of the articular and vascular manifestations of polymyalgia rheumatica and giant-cell arteritis.


Immunoglobulin structure: variability and homology.


Antigenic streptococcal components in acute glomerulonephritis. Fluorescein-labeled immunoglobulin G fractions from serums of patients with acute glomerulonephritis and from many normal serums stained the glomerular basement membrane and mesangium of renal tissue from patients with early acute glomerulonephritis; these serums did not stain the corresponding tissues from patients with any other kidney disease. Previous absorption of the serum fraction with frozen and thawed nephritogenic beta hemolytic streptococci abolished all staining. Other bacteria studied did not abolish the staining. Only the plasma membrane of the streptococcus absorbed the immunoglobulin G fraction; such absorption eliminated staining. Fluorescein-labeled antiserums against streptococcal plasma membrane had staining properties similar to patients' serums.


Human serum inhibitor of C'1 esterase: identity with alpha-2-neuraminoglycoprotein. A comparison of highly purified C'1 esterase inhibitor from human serum and alpha(2)-neuraminoglycoprotein from human plasma by immunofusion, immuneelectrophoresis, and discgel electrophoresis showed them to be antigenically identical.


Antigenic histamine release from fractionated and unfractionated peritoneal cells from sensitized rats.


Mitochondrial malic enzyme: the source of reduced nicotinamide adenine dinucleotide phosphate for steroid hydroxylation in bovine adrenal cortex mitochondria.


Inhibition of mitochondrial respiration by uncouplers of oxidative phosphorylation. II. The site of inhibition of succinate oxidation by the uncouplers.


Monoclonal immunoglobulins from random mutations.


The nature of the erythrocyte coating substance in tumour-bearing rats.


A nasal decongestant for high-altitude flying.


Serendipitous precise and unique staining of cell nuclei.


Observations on serum proteins in chronic schizophrenia.


Phosphorus analogs of nitrogenous drugs. II. 10H-Dibenzo[1,4]thiaphosphorins as central nervous system depressants.


An aziridinone derived from 1-aminoadamantane.


3-(Dialkylamino)methyladamantane-1-carboxylic acids.


Synthesis of some antithyroid compounds. I.


Effect of actinomycin-D on antibody synthesis by spleen cells of immunized rats.


Electrophoretic study of the serum proteins of normal and "lymphoid tumour"-bearing Xenopus.


Clinical and biochemical studies of plasmacytic and monocytic dyscrasias and their interrelationships.


Catalase activity of yeast grown in anaeronic conditions.


Infrequently encountered infections with gram-positive bacilli.


Evaluation of thyroid function during and after pregnancy.


Thyroid function in human pregnancy. II. Serum butanol-extractable iodine values of pregnant women 14 through 44 years.


Innervation of the human umbilical cord and umbilical vessels.


Observations on the fine structure of peripheral nerve myelin.


The effect of sleep upon the electroencephalogram in patients with brain tumors.


Alteration in the sleep-wakefulness patterns by benzodiazepines in the cat.


Reticular influences on lateral geniculate neuron activity.


Orienting and habituation to auditory stimuli: a study of short term changes in average evoked responses.


Light-induced epilepsy in the baboon, Papio papio: cortical and depth recordings.


A special purpose digital computer (Biomac 500) used in the analysis of the human electromyogram.


Suppression of focal spikes by somato-sensory stimuli.


An interval-to-frequency converter for neurophysiological use.


Acoustic evoked potentials and amplitude of the EEG.


The identification of the types of Langerhans islets cells. I. Light microscopical study.


Amino acids of the adrenal medulla and the effect of potassium dichromate oxidation on them.


Cytochemical localization of acid mucosubstances within rabbit, chicken, frog and fish skeletal muscle fibers.


The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor. The fraction of human serum designated as C'1 esterase inhibitor is known to inhibit the action of C'1 esterase, a plasma kallikrein, and PF/Dil, an enzyme in plasma enhancing cutaneous vascular permeability. In the present study, C'1 esterase inhibitor has been found to block the actions of plasmin and the C'1r subcomponent of the first component of complement, and to retard the generation of PF/Dil. No inhibition of blood clotting or of the generation of plasmin was demonstrable.


Influence of defined incompatibilities and area of burn on skin-homograft survival in burned-subjects.


Effector mechanisms in immunity.

Effector mechanisms in immunity.


Cadaveric renal transplantation. An analysis of 65 cases.


Low plasma-bilirubin in epileptics on phenobarbitone.


Transplantation of allogeneic haemopoietic tissue in adult anaemic mice of the W series using antilymphocytic serum.


Intestinal capillariasis. A new disease in man.


Device for control of oxygen concentration with Bird respiration.


Diagnosis of Wilson's disease in children with liver disease. A report of two families.


Government in public?

Government in public?


Information about adverse effects of drugs.


Renal transplantation.

Renal transplantation.


Hyaline-membrane disease, oxygen, and pulmonary fibroplasia.


Interferon and herpes conjunctivitis.

Interferon and herpes conjunctivitis.


Analysis of psychiatric diagnosis.

Analysis of psychiatric diagnosis.


Examination of clinical examiners.

Examination of clinical examiners.


Two systems of marking objective examination questions.


The aggressive psychopathic offender.

The aggressive psychopathic offender.


International health.

International health.


Royal Commission on Medical Education.

Royal Commission on Medical Education.


General practice and the green-paper.

General practice and the green-paper.


Teaching behavioral science.

Teaching behavioral science.


Teaching behavioural science.

Teaching behavioural science.


Antibiotics in renal failure.

Antibiotics in renal failure.


Oral contraceptives and carcinoma-in-situ.


Electrolyte abnormalities in porphyria.

Electrolyte abnormalities in porphyria.


Diet and cardiovascular diseases.

Diet and cardiovascular diseases.


Arginine infusion and growth-hormone secretion.


Feeding the newborn.

Feeding the newborn.


Hospital scientists.

Hospital scientists.


Radiation treatment of thyrotoxicosis.

Radiation treatment of thyrotoxicosis.


Early detection of cancer.

Early detection of cancer.


Atropine psychosis.

Atropine psychosis.


Alterations in fibrinolysis and blood coagulation.


Alterations of fibrinolysis and blood coagulation.


Family-planning services in Africa and the Middle East.


General practitioner and obstetrician.

General practitioner and obstetrician.


Careers for dental technicians.

Careers for dental technicians.


Chalones and cancer.

Chalones and cancer.


Blood potassium, glucose, and insulin in cardiac surgery.


The anaesthetist's place.

The anaesthetist's place.


Anticonvulsant drugs and congenital abnormalities.


Mallet finger.

Mallet finger.


William Michael Court Brown.

William Michael Court Brown.


Renal transplantation in man. Experience in 35 cases.


Widening of the cranial sutures: a roentgen observation during periods of accelerated growth in patients treated for deprivation dwarfism.


Acid mucopolysaccharides in cultured fibroblasts of cystic fibrosis of the pancreas.


Serum protein bound iodine (PBI) level and its relation to the clinical state, thyroid iodine uptake and the level of protein bound radioactive iodine (PBI-131).


Granulomatous thymoma or Hodgkin's disease of thymus? A clinical and histologic study and a re-evaluation.


Characteristics of new cell lines derived from Burkitt lymphomas.


Immunoglobulin-producing cells in human pericancerous lymph nodes.


Hormonal cytology of pregnancy.

Hormonal cytology of pregnancy.


Induction of both reaginic and blocking antibodies with a low molecular weight fraction of timothy pollen extract.


Biochemical indices of fetal condition.

Biochemical indices of fetal condition.


Disodium cromoglycate, a new compound for the prevention of exacerbations of asthma.


Development of broad audio-visual services with limited facilities.


Rear-screen projection.

Rear-screen projection.


Low-budget exhibit production.

Low-budget exhibit production.


Residual activity of benzene hexachloride formulations on the bovine coat.


Haemoglobin electrophoresis.

Haemoglobin electrophoresis.


Hypogammaglobulinaemia in the United Kingdom. Summary report of a Medical Research Council working-party.


Anticoagulants and coronary artery disease.


Conjugates of chitinase with fluorescein isothiocyanate or lissamine rhodamine as specific stains for chitin in situ.


Dihydrostreptomycin in the isolation of pathogenic Escherichia coli.


Studies on the gomori-positive glial cells. I. The changes in the periventricular gomori-positive glial cells in rats of various ages.


Immunoglobulin levels in infants with low birth weights.


Immunoglobulins in 13-15 trisomy syndrome due to a translocation.


NAD(P)-linked oxidoreductions and the nicotinamide nucleotide specificity of glutamate dehydrogenase in rat-liver mitochondria.


Control of nicotinamide nucleotide-linked oxidoreductions in rat-liver mitochondria.


Spontaneous rupture of the spleen on plasma cell leukemia.


Metabolism of organic insecticide chemicals.


Genetics and structure of hemoglobin lepore.


Heme synthesis in impaired globin synthesis.


Synthesis of adult and fetal hemoglobins in the cord blood.


Differences between the structure and function of human adult and foetal erythrocytes.


Vectorial aspects of 2,3-diphospho-D-glycerate: 2-phosphohydrolase in the human red cell membrane.


Purification and characterization of diphosphoglycerate phosphatase from human erythrocytes.


The mature erythrocyte and lipid biosynthesis.


Serum proteins in guinea pig scurvy.

Serum proteins in guinea pig scurvy.


Balloon catheter palliation for infants with transposed great arteries. Report of two cases with successful balloon atrial septostomy.


Detection of intracellular botulinum E toxin by fluorescent antibody technique.


Immunological aspects of infertility.

Immunological aspects of infertility.


Histamine release, pulmonary blood shunts, and rapid, shallow breathing in the dog.


Anticryptoccal serum factors in experimental liver disease.


Purificaton and morphology of Tribec arbovirus.


A study on the fixation of large mature feline myelinated ventral lumbar spinal-root fibers.


Study of monozygotic twins discordant for schizophrenia. Some biologic variables (lactate-pyruvic ratio; 3,4-dimethoxyphenlethylamine; S19 macroglobulin; antirabbit red cell hemagglutin; protein bound iodine).


Leucocytic lysosomal hydrolases in the process of pinocytosis.


Scleroderma, immunological and genetic disease in three families.


Studies on the gamma-globulin group systems in the Polish population.


Adrenal medullary basophilia in ox, pig and sheep. A histochemical, immunohistochemical and cell fractionation study.


The surgical anatomy of the benign prostatic hypertrophy.


Relationship of amyloid to aging. Review of the literature and systematic study of 83 patients derived rom a general hospital population.


Oral mucosal cytology in infant malnutrition.


Variation of the alpha 2-macroglobulin homologue with age in some mammals.


Plasma prothrombin during treatment with Dicumarol. I. Immunochemical determination of its concentration in plasma.


Plasma prothrombin during treatment with Dicumarol. II. Demonstration of an abnormal prothrombin fraction.


Nuclear size in diagnosis of Entamoeba histolytica on stained smears.


Primary inducible fluorescence in secretory granules of tumor cells supravitally stained by a toluidine blue dye.


Transitional epithelium of urinary tract in normal and dehydrated rats. A histochemical and electron microscopic study.


Gamma benzene hexachloride in treatment of pediculosis and scabies.


Implications for clinical nursing practice from a study of postoperative open heart patients.


Kidney transplantation.

Kidney transplantation.


Hospital routines as rites of passage in developing maternal identity.


Aortic aneurysm: a patient study.

Aortic aneurysm: a patient study.


Implantation of a carotid nerve stimulator.


Care of patients with the carcinoid syndrome.


Patient care in progressive systemic sclerosis.


Direct current cardioversion in digitalized patients with mitral valve disease.


Human pituitary nuclear inclusions vs invaginations.


Deficiency of vitamin B12-binding alpha globulin in two brothers.


The detection of imidazoles including histidine and some of its derivatives in biological fluids.


A new orthodontic teaching simulator.

A new orthodontic teaching simulator.


Electrophoretic pattern of serum proteins in myocardial infarction in tropics.


Clinical diagnosis of acute massive pulmonary embolism.


A new coronary prognostic index.

A new coronary prognostic index.


Mortality in a coronary-care unit analysed by a new coronary prognostic index.


Immunoglobulin for the prevention of infectious hepatitis in persons working overseas.


Evidence for soluble immune complexes in the pathogenesis of the glomerulonephritis of quartan malaria.


Effect of fasting on glucose and insulin metabolism of obese patients.


Effect of corticotorphin on skeletal maturation and linear growth in six patients with severe asthma.


Growth-hormone release by glucagon.

Growth-hormone release by glucagon.


A new biopsy needle.

A new biopsy needle.


Perinatal problems.

Perinatal problems.


Sighs and porters.

Sighs and porters.


Salt and blood-pressure.

Salt and blood-pressure.


Hawk or dove?

Hawk or dove?


Automated protein analysis.

Automated protein analysis.


Green-Paper tiger.

Green-Paper tiger.


Human genetics.

Human genetics.


Seebohm sophistry and Green-Paper gallimaufry.


A personal medical reference index.

A personal medical reference index.


Fresh evidence a year later.

Fresh evidence a year later.


Hospital treatment of acute poisoning.

Hospital treatment of acute poisoning.


Duration of pregnancy.

Duration of pregnancy.


Retiring old drugs gracefully.

Retiring old drugs gracefully.