Role of lupus erythematosus factor and accessory serum factors in production of extracellular nuclear material.


The relationship between cortical synchrony and behavioral inhibition.


Pathogenesis of endemic goitre in Eastern Nigeria.


Electroencephalographic correlates of learning in subcortical and cortical structures.


The effect of sleep onset on the auditory averaged evoked response.


The effects of local cooling of the cortical surface on the motor cortex response following stimulation of the pyramidal tract.


Effects of diphenylhydantoin on spontaneous and evoked activity in the cat under chloralose anesthesia.


Micro-pipette pullers: some detail and technology.


Analog inked-trace reader for automatic continuous high-speed multi-channel operation.


Shifts of cortical standing potential in hypoxia and asphyxia.


Temporal epilepsy and hippocampal discharges induced by oxyprivic anoxia.


Cortical DC potential, EEG and membrane potential during seizure activity and hypoxia.


EEG alterations in the course of clinical and experimental investigations of tissue hypoxia.


Analysis of blood gases in patients with "generalized slowing" of the EEG with special reference to the study of the peripheral PvO2.


EEG investigations in the post-operative transitory period following general surgery and open heart surgery with extracorporeal circulation.


EEG features during open heart surgery under extracorporeal circulation. Personal experience of 30 cases.


EEG characteristics of migranous cerebral attacks of a deficitory type (hemiplegic migrane).


Triphasic potentials following a state of deep coma(coma dépassé) in patients with intoxication by hypnotics.


The restitution of EEG after strangulation hypoxia and decerebrate rigidity. Case demonstration with special clinical progress.


Flattening of the EEG and periodic discharges during acute illnesses in the child involving the brain. Discussion of the role of cerebral anoxia.


The EEG treatment of hypoxic and other cerebral disorders by improvement of the blood supply.


Methods of assessing neonatal anoxia with EEG studies.


On the value of the carotid compression test as a provocative method in clinical electroencephalography.


Specificity of neonatal anoxia in the EEG pattern of the child of school age who presents with praxic or language difficulties.


Clinical and electrophysiological aspects of post-anoxic myoclonus with particular reference to action myoclonus.


Electroencephalographic aspects of acute and chronic cerebral hypoxia in cerebral circulatory insufficiency.


Effects of diazepam (Valium) on the responses evoked by light stimuli in man (lambda waves, occipital "driving" and average visual evoked potentials).


Thyrotoxic encephalopathy.

Thyrotoxic encephalopathy.


EEG studies in uraemic patients during extracorporeal haemodialysis or intermittent peritoneal dialysis.


Definition and value of the average alpha rhythm and its topography.


Recording the EEG spectrum.

Recording the EEG spectrum.


Electroencephalographic foci: conditions for their localization.


EEG, respiratory, ocular and myographic correlations in the Pickwick syndrome and other apparently related conditions: proposal for a hypothesis.


Treatment of infantile spasms with Mogadon.


Electromyographic F waves in normal and pathological conditions.


Diagnostic and prognostic value of the electromyographic findings in polyradiculoneuritis.


A method of demonstrating and measuring disturbances of central innervation: electrotonomyography.


Electromyographic studies in experimental cortisone myopathy.


Cortisone neuromyopathies. (An electromyographic study of 28 children).


Variations of proprioceptive reflex excitability during clinical absences and at the beginning of photosensitive centrencephalic grand mal.


Electrotherapy of spasticity.

Electrotherapy of spasticity.


Treatment of spasmophilia in the adult by magnesium lactate.


Spasmophilia: a clinical neuro-muscular form of primary magnesium deficiency.


A case of the epileptic form of latent tetany due to magnesium deficit.


Polygraphy in differential diagnosis of paroxysmal loss of consciousness.


The electroencephalographic effect of mental and physical activity in patients with brain atrophy.


Measurement of the frequency content of the EEG by manual period and frequency analysis.


Computer frequency analysis of the electroencephalogram.


EEG in phenylketonuria.

EEG in phenylketonuria.


EEG--head injuries and late progression.


Steroid treatment of infantile spasms with hypsarrhythmia.


EEG findings in two patients with a rare degenerative nervous disorder.


Influence of ischaemia on muscle fibre activity.


H and F reflexes in man.

H and F reflexes in man.


Electromyographic examination of the erectores spinae in patients suspected of having nerve root lesions.


Can the computer of average transients be of additional help in EMG.


Impulses recorded with micro-electrodes in human muscle nerves during stimulation of mechanoreceptors and voluntary contractions.


Motor unit potentials and fibrillation potentials from the musculus recti oculi in comparison with action potentials from normal musculus biceps brachii.


Toxicity of contrast media. Experimental electrophysiological studies in the rabbit.


Electrophysiological observations in cases of partial and total rupture of the Achilles tendon.


The effect of sub-paralytic doses of curare on neuromuscular transmission.


Vibratory induced motor effects in normal man and in patients with spastic paralysis.


Experiences with EEG recordings during spontaneous night sleep in patients with epilepsy.


The prognosis of epilepsy with special regard to the course of EEG.


Automatic EEG tape computer system for analog-digital data processing of frequency spectral information.


Physiological mechanism of the slow 10c/sec cortical rhythmic activity.


An experimental study of auto- and cross-correlations of spontaneous activity as recorded from scalp and cortex.


Influence of tissue hypoxia upon the EEG-cerebral blood flow relationship.


Regional cerebral blood flow and EEG frequency content.


The path of the ultrasound beam through the brain in echo-encephalography.


The electroencephalogram in children with febrile convulsions.


A technique for studying the time course of small evoked potentials.


Eye movement and the summated lambda response.


Potentials evoked by tapping recorded from the human scalp over the cortical somato-sensory region.


Visual potentials evoked in binocular rivalry.


Electrocoagulation of the amygdalae in an epileptic patient.


Jakob-Creutzfeldt disease-EEG observations with special reference to occurrence of complexes and their relationship to other body events.


Variations in cortical oxygen availability related to sensory stimulation, operant response and spontaneous delta bursts.


Seizures following resuscitation in children.


Effect of propylthiouracil and methimazole on the oxygen comsumption of hypothyroid rats receiving thyroxine or triiodothyronine.


Thin-layer gel filtration of thyroid iodoproteins. Studies on rat transplantable thyroid tumors.


Effect of methimazole on amino acid utilization by calf thyroid slices.


Histamine and histaminase release by guinea pigs at various intervals during anaphylactic shock.


Methyl green as a stain for amyloid.

Methyl green as a stain for amyloid.


Bacilli-lipid associations in Whipple's disease.


Amyloidosis in mice bearing a transplantable plasma cell tumour.


Silver methenamine stain for electron microscopy.


Subunits in chloroplast lamellae.

Subunits in chloroplast lamellae.


Relation of blood-glucose to haematocrit, birthweight, and other body measurements in normal and growth-retarded newborn infants.


A new method of active immunisation to autologous human tumour tissue.


Treatment of urinary schistosomiasis with trichlorophone.


Cleft lip and palate deformities and insulin antagonism.


Reliability of pupillary changes as a clinical sign of hypoxia.


Effect of calcium on mental symptoms in partial parathyroid insufficiency.


In-vivo and in-vitro effects of polyvinylpyrrolidone on platelet adhesiveness in human blood.


Two cases of hepatitis due to Toxoplasma gondii.


Possible immunological factors in human malignant melanoma in Uganda.


A bedside monitor for use with central dialysate supply.


Rethinking medical records.

Rethinking medical records.


Cranial arteritis and polymyalgia rheumatica.


Summaries and selective destruction as a solution to the hospital record storage problem.


Growth-control mechanisms.

Growth-control mechanisms.


Training in medical laboratory technology. A statement on behalf of the Institute of Medical Laboratory Technology.


Medrogestone therapy in advanced endometrial adenocarcinoma.


Application of cryosurgery to gynecologic malignancy.


A plaque assay for lambda attachment.

A plaque assay for lambda attachment.


The effect of gamma-globulin in prevention of fibrinogen-transmitted hepatitis.


Electron microscopic localization of viral antigens in mouse mammary tumors by ferritin-labeled antibody. I. The homologous systems.


Evidence for the incorporation of L-thiazolidine-4-carboxylate into actinomycins by Streptomyces antibioticus.


Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. Chemical and immunological characterisation with special reference to multiple sclerosis.


Effect of dihydrostreptomycin of the binding of specific sRNA to 30S ribosomal subunits and re-associated 70S ribosomes.


Evidence for estradiol binding sites in the hypothalamus-effect of drugs.


The effect of carcinogenic and noncarcinogenic compounds on the O-dealkylating activity of the hepatic microsomal enzyme system of the rat.


The influence of nutritional change on polyribosomes of the liver.


The effects of overstimulation: rat people.


Sense, affect, and image in development of the symbolic process.


The symbolic process of recidivist and non-recidivist children as assessed by the Kahn test of symbol arrangement.


Column chromatography and spectroscopy in the analysis of airborne polycyclics.


Amino-terminal amino-acid sequences of human plasma 3S gamma 1-globulin and carbonic anhydrase B.


Detection of genetic antigens utilizing gamma globulins coupled to red blood cells.


Demonstration of copper and acid phosphatase activity in hepatocyte lysosomes in experimental copper toxicity.


Effect of actinomycin on protein synthesis by lymphocytes.


Observations on the RNA metabolism of leukaemic cell cultures.


Antigen and antibody localization in Hassall's corpuscles.


Specificity in transcription of the reovirus genome.


Synthesis of gamma G antibody and immunoglobulin on polyribosomes in a cell-free system.


Leprosy. A preliminary review of the experimental evaluation of drugs for the treatment of leprosy.


Myocardial effects of bishydroxycoumarin and warfarin.


Disc electrophoresis of saline extracts of Schistosoma mansoni.


Ultrastructure of Anaplasma marginale fixed with glutaraldehyde and osmium tetroxide.


A source of false iodine-131 uptake and protein bound iodine values in dogs.


On possible mechanisms of hyposensitization: some pertinent laboratory findings.


Changes in ultrastructure of embryonic chick liver during morphogenesis.


Aggregation of Ig G globulin in vivo. 3. Study of Ig G globulin aggregation by unimolecular layer method.


Intracellular recording from cortical pyramids and small interneurons as identified by subsequent staining with the recording microelectrode.


Soluble NADH and NADPH dehydrogenases in the optic lobes of Sepia officinalis. I. Dicumarol-sensitive enzymes.


Soluble NADH and NADPH dehydrogenases in the optic lobes of Sepia officinalis. II. Dicumarol-insensitive enzymes.


A stable silver solution for axon staining in paraffin sections.


Brain vascular permeability to I-125 gamma globulin and leukocytes in allergic encephalomyelitis.


Effect of dietary carbohydrate on the serum protein components of two strains of rats.


Reproductive death of irradiated cultured mammalian cells and its relation to mitosis.


Intracellular development of infectious bronchitis virus.


Multiple intracerebral hemorrhages of unusual nature. A clinical and pathological case report.


Our experience in the surgical treatment of malignant and benign esophageal tumors.


Variations in the isotopic composition of carbon in urban atmospheric carbon dioxide. Measurement of the abundance of atmospheric carbon dioxide as an indicator of air pollution has been of very limited value because of variations in urban areas in the substantial concentration of natural carbon dioxide produced from combustion and noncombustion (natural) sources. A solution to this problem is the use of precise isotopic assay of ratios of carbon-13 to carbon-12 in atmospheric carbon dioxide. There is very little variation of carbon isotopic composition in samples taken over rural or urban areas where rapid mixing and diffusion of gaseous combustion products is possible. Significant differences in this composition in samples taken at centrally located points at street level in the lower Manhattan business district show an increase in concentration of atmospheric carbon dioxide of roughly 20 percent produced primarily by automobile exhaust.


Palliative surgery for mitral atresia.

Palliative surgery for mitral atresia.


Intrapericardial aortopulmonary anastomosis for tetralogy of Fallot. Clinical experience.


IgG myeloma in cerebrospinal fluid with a total protein of 32 mg.-100 ml.


Prophylaxis in rubella.

Prophylaxis in rubella.


Catabolism of serum gamma G-globulins in a cancer patient and a normal volunteer.


Contingent negative variation and evoked responses recorded by radio-telemetry in free-ranging subjects.


Phantom spike-waves and the fourteen and six per second positive spike pattern: a consideration of their relationship.


Spectral analysis of low frequency components in the electrical activity of the hippocampus during learning.


The pseudomyasthenic syndrome of Eaton and Lambert: an electrophysiological study.


Averaged responses from association areas in waking cat.


The relationship between association responses and activity in the pyramidal tract.


Prevention of supersensitivity in partially isolated cerebral cortex.


The distribution and characterization of the erythrocyte. Receptors in man and animals for lectins from Maclura pomifera.


Experimental herpes simplex encephalitis. Electroencephalographic, clinical, virologic, and pathologic observations in the rabbit.


Effect of oral contraceptives on vitamin K-dependent clotting activity.


Comparative EEG frequencies in Rhesus, Stumptail, and Cynomolgus monkeys.


The use of methohexitone in sleep electroencephalography.


Indwelling multiple micro-electrodes in the brain.


Simultaneous investigation of operant behavior and certain psycho-physiological activities.


The influence of collicular and frontal oculo-motor structures on the sensory reactivity of the cortical visual area.


Severe acute necrosis of the pons with long survival. Electro-clinical symptoms and absence of cerebral lesions.


EEG in Jakob-Creutzfeldt-Heidenhain's disease.


Tentative application in psychiatry of the contingent negative variation.


A study of lateralized convulsions in children.


"Petit mal variant" or Lennox syndrome.

"Petit mal variant" or Lennox syndrome.


Comparison of the sleep-waking cycle in two animal species in various experimental conditions.


Paradoxical sleep and hormonal equilibrium; interdependence between paradoxical sleep and sexual functions in the rabbit.


Influence on sleep of hyperthyroidism.

Influence on sleep of hyperthyroidism.


Recent findings in experimental insomnia in the rat.


On a case of narcolepsy with paroxysmal phenomena. A diurnal and nocturnal study.


Comparative polygraphic study of the 24 hour cycle in Pickwickians, the obese and narcoleptics.


Unspecific EEG abnormalities in night sleep.


Disturbances of the organization of sleep in the pathological newborn.


EEG study of sleep in children with cerebral motor disabilities.


The sleep of enuretic children.

The sleep of enuretic children.


Paroxysmal episodes during going to sleep and sleep in young children.


Disturbances of sleep in patients with confusional and demential syndromes.


New clinical findings on the subjective experience of the "intermediate stages" of sleep.


Electrographic organization of spontaneous night sleep after pre-frontal lobotomy.


Signs of diurnal sleep in the post-concussional patient (examined in a dark room).


Study of the 24 hour cycle in prolonged coma. A. Electro-clinical.


Reorganization of nocturnal sleep after post-traumatic coma.


Deprivation of sleep as a method of activating epileptic attacks.


A controversial problem: insomnia in the guinea pig.


Comparative study of spontaneous sleep and nocturnal sleep under neuroleptics in mental patients.


Action of Mogadon on the stages of REM sleep.


Symonds' nocturnal myoclonus.

Symonds' nocturnal myoclonus.


The organization of night sleep in epileptics.


Effects of attacks on the organization of the night sleep of epileptics.


Spirographic and EMG analysis of respiration during sleep monitored by EEG in normal man.


Disturbances of sleep in two brain-stem vascular syndromes, one with anatomo-clinical confirmation.


The EEG of abnormal sleep in a child suffering from lethargic encephalitis of viral origin.


Post-natal maturation of the auditory system: electrocortical responses to pure tone stimulation.


A comparison between the effects of circumscribed lesions of the reticular formation and of the subthalamus.


The EEG and the impairment of sleep by traffic noise during the night: a problem of preventive medicine.


The six per second spike and wave complex (the wave and spike phantom).


Some observations on the physiological mechanisms of "thalamic" pain.


Electro-clinical correlations of polyphasic spike discharges.


Further studies on reference electrodes.


The amygdala and hippocampus in olfactory aura.


Centrencephalic seizure discharges in patients with focal hemispheral lesions.


Death?

Death?


Electroencephalograms in the 65 and over.


Nuclear changes in the course of development of the sea urchin studied by means of Hale staining.


Basic ribonucleoprotein granules in the Haliotis oocyte.


Presence of collagen in plant nuclei.

Presence of collagen in plant nuclei.


Neurosecretory cells in a cestode, Hymenolepis diminuta. A group of nerve cells in the rostellum become progressively more fuchsinophilic during the first 16 days of development; they then release their secretion into their axons at about the time that the first proglottid is released.


Colostral immunoglobulin-A: synthesis in vitro of T-chain by rabbit mammary gland. When minced mammary tissue from lactating rabbits was incubated in vitro with C(14)-labeled lysine and isoleucine, it incorporated radio-activity into colostral immunoglobulin A. The only portion of this colostral molecule with significant labeling was T-chain, with little or no labeling of light or heavy chains. It was thus demonstrated that T-chains are synthesized by mammary gland. Because the remainder of the molecule was derived from unlabeled material, in vivo it was probably derived from serum.


Ultrastructure of gamma-M immunoglobulin and alpha macroglobulin: electron-microscopic study. Electron microscopy of purified Waldenström macroglobulins and normal human and rabbit gammaM immunoglobulins revealed spider-like structures with five legs varying in length and often joining a central ring. Usually only the central more rigid part of this structure (about 150 by 170 angstroms) was clearly visible, but occasionally particles were seen with longer very flexible legs having a total span of about 350 angstroms. Molecules of gammaM antibody retained antibody activity during preparation for electron microscopy. Human and rabbit alpha macroglobulins revealed more rigid symmetric structures (100 by 200 angstroms) which resembled the Russian letter .


Reiter Protein Complement-Fixation (RPCF) test as a serological test for syphilis. A clinical study.


Exfoliative cytology of human horny layer. Methods of cell removal and microscopic techniques.


The protein-polysaccharide complex of the developing human periodontium.


Odontoblast aspiration and fluid movement in human dentine.


Ultrastructural significance of histochemical reactions on the enamel surface of erupted human teeth.


Autoimmunity and termination of immunological unresponsiveness.


Functional stability of messenger RNA to potato tuber slices.


Thyroid activity in relation to prognosis in mammary cancer.


Regional anesthesia. A critical assessment of its place in therapeutics. E. A. Rovenstine Memorial Lecture.


Correlation of dose of x-radiation to the rat thyroid gland with degree of subsequent impairment of response to goitrogenic stimulus.


Scabies.

Scabies.


Testing of wheat flour for the presence of nitrite and nitrosamines.


Renal transplantation. A nursing care study.


Gaucher's disease. Review of the literature and report of twelve new cases.


Family diagnosis and therapy using videotape playback.


The therapeutic nursery as an aid in diagnosis of delayed language development.


Suxamethonium induced bronchospasm.

Suxamethonium induced bronchospasm.


Quenching mouse liver in isopentane and propane at -155 C. Some morphologic and chemical effects.


The functional activities of IgG and IgM anti-A and anti-B.


The reactivity of subunits of IgM anti-B.


The IgA system. 3. IgA levels in the serum and saliva of pediatric patients--evidence for a local immunological system.


The dynamic behaviour of Hassall's corpuscles and the transport of particulate matter in the thymus of the guinea-pig.


Prenatal treatment of cretinism: preliminary studies of its value in postnatal development.


Thyroid-stimulating hormone in thyroid dysgenesis.


Autosomal linkage between the albumin and Gc loci in humans. Naskapi and Montagnais families segregating for albumin Naskapi give evidence for close linkage of the Gc and albumin loci with a high probability. One possible case of crossover is included in the data.


Plasma protein and lipid pattern in the nephrotic syndrome.


Protein-losing enteropathy associated with gastrointestinal allergy.


Resolution and organization of platelet-rich mural thrombi in carotid arteries of swine.


Vitamin E deficiency: a sequential study by means of light and electron microscopy of the alterations occurring in regeneration of skeletal muscle of affected weanling rabbits.


A light and electron microscopic study of hyaline droplet and vacuole formation in the adrenal glands of rats treated with methylandrostenediol.


Origin of cerebrospinal fluid gamma globulin in subacute sclerosing leukoencephalitis.


The pathogenesis and prevention of Rh immunization.


Treatment of thyrotoxicosis.

Treatment of thyrotoxicosis.


Antilymphoid sera in clinical renal allotransplantation.


Clinically useful antimicrobial agents. Some current concepts in therapy.


Observations on the histochemical basis of reticulin staining (bromine-silver method).


Comparison of guinea pig gamma 1-and gamma 2-immunoglobulins by peptide mapping.


Use of thin-layer chromatography for the preliminary diagnosis of Refsum's disease (Heredopathia atactica polyneuritiformis).


Further observations on amphiphil cells in the pancreatic islets.


The effect of certain steroids on the serum protein concentrations of the lizard, Uromastix hardwickii Gray.


Relationship of "epithelial rests of Malassez" to other periodontal structures.


The distribution, structure, origin and nature of the dental cuticle of Gottlieb.


The influence of development on the number and appearance of silver grains in electron microscopic radioautography.


Histologic localization of follicle-stimulating and luteinizing hormones in the rat testis.


Thin layer chromatographic study of lipid extraction from cryostat sections of rat hypothalamus by some fixatives.


Demonstration of biologic polyanions by alcian blue in salt solutions and by alcian yellow or hexadecylpyridinium-hexathiocyanatoferrate.


Peripheral neuropathy of metachromatic leucodystrophy: observations on segmental demyelination and remyelination and the intracellular distribution of sulphatide.


A technique of staining sections of paraffin-embedded plant materials without employing a graded ethanol series.


The structure and assembly of collagen fibrils. I. Native-collagen fibrils and their formation from tropocollagen.


Experimental study of decidualization.

Experimental study of decidualization.


Production of lymphocytosis by polysaccharide polysulphates (heparinoids).


The histochemical properties of some periodate-reactive mucosubstances of the pregnant Syrian hamster before and after methylation with methanolic thionyl chloride.


Synthesis of ribonucleic acid and histone change during spermatogenesis in the grasshopper Chortophaga viridifasciata.


Maturity at birth and adult protein bound iodine.


N- and C-terminal sequences of a heavy chain disease protein and its genetic implications.


Temperature changes following systemic and intracerebral administration of naphazoline and B-45 to the rat.


The estimation of IgM immunoglobulin in dried blood, for use as a screening test in the diagnosis of human trypanosomiasis in Africa.


The indirect fluorescent antibody technique applied to dried blood, for use as a screening test in the diagnosis of human trypanosomiasis in Africa.


Detection of morphine and related alkaloids in mice homogenates by thin layer chromatography.


The G. S. F. technique for electron microscopy differentiation of genetic material.


Studies on the lipoid content of M. domestica L strains susceptible and resistant to DDT and lindane.


Posttransfusion hepatitis.

Posttransfusion hepatitis.


Studies on ragweed pollen allergens. V.

Studies on ragweed pollen allergens. V.


Identical twins with short stature, elevated IgA, and asthma.


Shoulder-hand syndrome. A case of unusual aetiology.


Prevention of Rh-hemolytic disease.

Prevention of Rh-hemolytic disease.


Notation for human immunoglobulin subclasses.


Phylogenetic studies on the immune response. II. The immune response of the Australian echidna Tachyglossus aculeatus.


Immunological studies of an atypical (myeloma) immunoglobulin.


The immunoglobulins in Hodgkin's disease.


Localization of mouse isoantigens on the cell surface as revealed by immunofluorescence.


The passive transfer of delayed hypersensitivity in the guinea-pig. II. The ability of passively transferred antibody to cause local inflammation and retention of antigen and the role of these phenomena in the passive transfer of delayed hypersensitivity.


Immunological studies concerning the nephritis of systemic lupus erythematosus. Antibodies were eluted from the isolated glomeruli prepared from the kidneys of 10 patients with the nephritis of systemic lupus erythematosus. Antibodies reacting primarily with buffer extracts of nuclei were eluted by acid treatment, and antibodies reacting mainly with DNA and nucleoprotein were eluted with deoxyribonuclease. Quantitative immunochemical studies revealed a high concentration of antinuclear antibody per milligram of gamma-globulin in glomerular eluates compared with that in the corresponding serums. The gamma-globulin of two eluates was found to consist predominantly of antinucleoprotein antibody. The selective elution of antinuclear antibodies was also indicated by the absence of other serum antibodies in the eluates. DNA antigen was demonstrated in the glomeruli of two kidneys with nephritis by means of isolated anti-DNA antibody labeled with fluorescein. In one of these cases, anti-DNA antibodies were also found concentrated in the glomeruli and, in the second, circulating anti-DNA antibodies were demonstrated in the patient's serum. The immunochemical evidence for the high specific activity of antinuclear antibodies and the association of DNA antigen with DNA antibody in glomeruli add further support for the antigen-antibody complex hypothesis for renal injury in systemic lupus erythematosus.


The stability and structure of mixed lipid monolayers and bilayers. I. Properties of lipid and lipoprotein monolayers on OsO4 solutions and the role of cholesterol, retinol, and tocopherol in stabilizing lecithin monolayers.


Immunoglobulin synthesis in mice: suppression by anti-allotype antibody. In the mouse, antibody directed against an immunoglobulin allotype, Ig-1b, passed from mother to offspring or injected into neonates, suppresses synthesis of immunoglobulin carrying Ig-1b. In allotype homozygotes as well as heterozygotes the allotype suppression is manifested both by a delay of several weeks in attaining initial detectable allotype levels and a reduction in allotype level continuing into adulthood. A possible mechanism for the differentiation of the immune system consistent with both the kinetics of suppression reported here for the mouse and the comparatively longer lived and more complete allotype suppression described for the rabbit is discussed. Evidence for a strong intralitter (as opposed to interlitter) correlation of age of onset of immunoglobulin allotype synthesis is presented.


Antihapten antibody specificity and L chain type. Two types of light polypeptide chain (kappa and lambda) are present in guinea pig immunoglobulins. The ratios of K/L molecules in anti-hapten antibodies differ sometimes markedly from that found in normal serum. Anti-DNP antibodies and anti-pipsyl antibodies have, respectively, a higher and a lower than normal K/L ratio. The possibility that the L chain type affects the range of configurations which the antibody-combining site may assume was investigated. Fractional precipitation of anti-DNP antibodies from serum of guinea pigs immunized with DNP(44)-BSA was performed using limiting amounts of antigen. Antibody fractions were purified from each precipitate, their affinities for epsilon-DNP-L-lysine measured by fluorescence quenching (K(0)) and the K/L ratio estimated by precipitation with specific antisera. Increasing concentrations of L molecules were found in fractions with decreasing K(0). In other experiments, fractional precipitation and purification of antibodies which cross-react with DNP was performed in serum of animals immunized with pipsyl-BGG. The K/L ratio in antibodies isolated from these fractions was much higher than in fractions which do not cross-react with DNP. These results show that K molecules are better adapted to react with the DNP hapten than L molecules. The K/L ratio in anti-DNP antibody was shown to increase in the course of immunization, at the same time that the K(0) is increasing. This rise in K(0) is markedly delayed when larger doses of antigen are employed.


The stability and structure of mixed lipid monolayers and bilayers. II. The effect of retinol and alpha-tocopherol on the structure and stability of lipid bilayers.


Experimental studies on the pathogenesis of leucodystrophies. 3. Cellular accumulation of injected sulphatides in brain, peripheral nerve and kidney.


Thyrotrophin test and carbimazole suppression test in hypometabolic patients without thyrogenic myxoedema.


Nuclear division in Neurospora crassa during conidiation and germination.


High frequency of mast cells in spleens of A-strain mice.


Neuronal argyrophilia in early degenerative states: a light and electron-microscopic study of the Glees and Nauta techniques.


Nucleolar changes in spinal ganglion neurons during the course of axon regeneration.


Morphological classification of the basal melanocytes of the human skin.


Elective localization of 3H-corticosterone in mast cells.


Studies on human lymphocytes stimulated in vitro with anti-gamma and anti-mu antibodies.


A simple staining technique for electron microscopy with lead-uranyl acetate.


Whole body sagittal technique in mice employing a new bio-autographic method: its utility for the evaluation of the body distribution of antibacterial drugs.


The separation and identification of vanilmandelic acid and related compounds by electrophoresis on cellulose acetate.


Physical and chemical characteristics of particulates in a diesel exhaust.


Whipple's disease: review of literature and case report.


Steroid amelioration of immunogenic insulin-resistant diabetes: a proposed mechanism.


Methadone in the relief of pain--a clinical note.


Structure and function of periderm. II. Inner structure of peridermal cells.


The visualization of the lining film of the lung alveolus with the use of Maillet's modification of Champy's method.


Hyperthyroidism: etiology and treatment.


A comparative evaluation of some staining techniques for intestinal protozoa in stool specimens.


The prevention of Rh haemolytic disease.


Ocular hemosiderosis.

Ocular hemosiderosis.


The prophylactic value of gamma globulin in rubella.


Effect of potassium perchlorate on the foetal rabbit thyroid.


A study of defective colour vision with the Ishihara test plates.


Mode of action of hydralazine on guinea pig atria.


Effect of some polycyclic aromatic hydrocarbons on protein synthesis in vitro. 1. The effect of the strongly carcinogenic polycyclic aromatic hydrocarbons benzo[a]pyrene, 3-methylcholanthrene and dibenz[a,h]anthracene and of the non-carcinogenic anthracene, pyrene and phenanthrene on protein synthesis was studied in vitro with subcellular systems from rat liver. 2. Both types of hydrocarbons affect amino acid activation and inhibit transfer of labelled amino acids from transfer RNA to ribosomes. 3. Only the carcinogenic compounds stimulate the incorporation of labelled algal-protein hydrolysate and of some individual amino acids into transfer RNA. The most active dose was 10mmug. under the conditions used. This effect is abolished by preincubation of pH5 enzymes with the carcinogens before the addition of radioactive amino acids. 4. The carcinogens stimulate the incorporation of some amino acids into ribosomal protein whereas the non-carcinogenic compounds have no such effects. 5. Polynucleotide-dependent stimulation of protein synthesis is greatly enhanced in the presence of the carcinogenic hydrocarbons when either free amino acids or transfer RNA charged with labelled amino acids are used. The non-carcinogenic compounds induce a partial inhibition of this process. 6. It is concluded, in agreement with other authors, that carcinogens may increase the number of active incorporation sites on both transfer and ribosomal RNA. Possible mechanisms of such an effect are discussed.


The effect of various combined chemotherapeutic agents on sarcoma 37 ascites tumor cells. I.


I-131-labeling of proteins by the iodine monochloride method.


Treatment of bladder cancer in Egypt, Part II: reconstruction technics.


A stereotaxic method of surgery for the relief of intractable pain.


The effect of various combined chemotherapeutic agents on sarcoma 37 ascites tumor cells. II.


Suppression of synthesis of allotypically defined immunoglobulins and compensation by another sub-class of immunoglobulin.


New research results in practical dream interpretation.


The effect of donor treatment with heterologous antilymphocyte globulin on kidney homograft survival.


Comparative studies on some enzymes of atypical and other mycobacteria.


Metachromatic properties of the typhoid Vi and O antigens.


Studies on the mechanism of action and of the Semple antirabic vaccine produced by the State Vaccine and Serum Institute, Warsaw.


Ataxia-telangiectasia.

Ataxia-telangiectasia.


Chromatographic analysis of the bleeding sap of inoculated and non-inoculated soya plants.


Mycolytic properties of some soil bacteria.


The spreading of cerebral edema from a cold injury in cats.


Adaptation of Rhizobium to Thiuram.

Adaptation of Rhizobium to Thiuram.


Antibiotic edeine. 3: Pilot plant scale fermentation and isolation of edeine complex.


Antibiotic edeine: IV: Desalting of edeine preparations by gel filtration technique.


Apparatus for continuous recording of bacterial growth under constant temperature.


Studies on continuous cultures of Pediococci.


Effect of the preparations isolated from peat on Saccharomyces fragilis.


Determination of histamine in small biopsies and histological sections.


A source of error in the study of Golgi-stained material.


Tumour glucose-6-phosphate dehydrogenase inhibition by actinomycin.


Metabolic studies on the accumulation of tetraphenylporphinesulfonate in tumours.


Electron microscopic evidence for the existence of an intercellular substance in rat cerebral cortex.


An electron-microscopic observation on the transfer of gamma-globulin and of ferritin protein through the human placenta.


Cytochemical studies on cytoplasmic RNA-associated basic proteins in oocytes, somatic cells, and ribosomes.


The cardiovascular adaptation of the dog to muscular exercise after graded hemorrhages.


The cardiovascular adaptation of the dog to muscular exercise. Role of the arterial pressoreceptors.


The cardiovascular adaptation of the anesthetized dog to muscular work after graded hemorrhages. Role of the arterial pressoreceptors.


Splanchnic hemodynamics during induced muscular exercise in the anesthetized dog.


Electrophoretic characteristics and their relationship to the enzyme activities of subcellular components in the amphibian muscle fibre.


Excretion and distribution of 32P in the organs of rats after a single administration of synthetic lysine-vasopressin.


Detection of a thyroid stimulating factor in a choriocarcinoma occurring in a male.


Electron transfer components of the phosphorylating respiratory chain.


Cyclophosphamide in the treatment of myelomatosis.


Correlating operating room nursing with the total nursing curriculum.


Immunohistochemical observations on the human silicotic nodule.


Immunological cross-reactivity between plasma membrane and endoplasmic reticulum of Ehrlich ascites carcinoma.


Cytological studies of the pathogenesis of chronic lymphatic leukaemia.


Antithrombin activity of serum from the native or recalcified blood.


Review of the Czechoslovak haematological literature published in the Czechoslovak journals in 1965. Biochemistry of blood.


Dissociation of low density lipoprotein-antibody precipitates at alkaline pH. The effect of alkaline pH on the dissociation of immunoprecipitates of low density lipoproteins (LDL) of the S(f) 0-10 class was studied by immunological and ultracentrifugal methods. The precipitates prepared at the equivalence point were dissolved and centrifuged in sodium chloride solutions of density 1.063 and pH's between 10.25 and 11.5. Analytical centrifugation of the top fraction, which floated at density 1.063, after dialysis against 0.9% sodium chloride of pH 7.4 revealed the presence of LDL and of soluble LDL-antibody complex. The amount of soluble complex was greater for the preparations obtained at lower pH than those obtained at higher pH and was undetectable at pH 11.5. The yield of immunoglobulin from the bottom fractions was maximal when the pH of the centrifugation medium was 11.0. Below pH 11.0, the greatly reduced yield of immunoglobulin was due partly to incomplete dissociation and partly to aggregation of soluble complex, while above pH 11.0 the decreased yield was possibly due to alkaline denaturation of the globulin. The immunoglobulin separated at pH 11.0 and dialyzed to pH 7.4 was reprecipitatable by LDL, and the reactivity did not seem to be appreciably influenced by the alkaline treatment.


Formation of cytotoxic factor by macrophages from normal guinea pigs.


Age changes in structure and responses of reticuloendothelial cells of rat liver.


Silver protein staining of nerve fibers in celloidin sections.


Improved resolution of fine caryological details by staining and examination before and after autoradiography.


Staining paraffin-embedded plant tissues with acridine orange.


A modified Bradley's squash technique for studying embryo sacs in gramineae.


An orcein-oil red O stain for concomitant demonstration of elastic tissue and lipid.


Acceleration of the Movat pentachrome one stain by heat.


Neutral red-fast green FCF, a single-solution stain for mammalian tissues.


Hormonal and biological activities of 3beta, 17alpha-diacetoxy-6-chloropregna-4,6-diene-20-one (AY-11,440).


Combined parasympathetic and beta-receptor blockade as a clinical test.


A brief method for the identification of the alpha-1-acid glycoprotein variants.


Microbial transformations of peptide antibiotics. I. Degradation of actinomycins by Actinoplanes species.


Cross-induction of Escherichia coli lysogens by an ultraviolet irradiation product. I. The dispensability of concurrent macromolecular syntheses in the formation of a metabolically unstable inducer.


Isolation of kappa and lambda chains from normal human gamma-G-immunoglobulin by ion-exchange chromatography.


Electrophoretic and immunological studies of plasma alpha-lipoproteins in avian erythroblastosis.


Isolation of a 0.5S gamma 2-globulin from normal human plasma.


Studies on the neurosecretory cells in the cerebral ganglion of Potamon magnum magm (Pretzman).


Serum proteins in ulcerative colitis: electrophoretic patterns in the inferior mesenteric artery and vein.


Lysis of Escherichia coli by ethylenediaminetetraacetate and phospholipases as measured by beta-galactosidase activity. A permeaseless mutant of Escherichia coli, which produces beta-galactosidase constitutively, was treated briefly with ethylenediaminetetraacetate and then with the phospholipases of Bacillus cereus. Cell lysis occurred, as indicated by an increase in beta-galactosidase activity and a decrease in absorbancy of the cell suspension. The susceptibility of the cells to attack by ethylenediaminetetraacetate and the phospholipases was markedly affected by the age of the cells when harvested. The results suggest that permeability changes may be associated with the activity of a phospholipase that specifically degrades phosphatidyl ethanolamine. A sonic-treatment method for determining the total beta-galactosidase content of E. coli cells, which is independent of their age when harvested, is described.


Gel filtration applied to some clinical problems.


Characterization of mycoplasma strains from cats. Mycoplasma strains (B1, B2, CS, and S1A) were isolated from the saliva of normal cats. These were compared with a strain (CO) isolated from the eye of a cat with severe conjunctivitis. On the basis of morphology, biochemical reactions, and antigenic composition, two distinct species were recognizable. Strains CO, B1, and B2 were antigenically unrelated to the other species tested; strains CS and S1A possessed antigenic components in common with Mycoplasma arthritidis, M. salivarium, M. hominis, type 1, and M. orale, types 1 and 2. It was tentatively suggested that the two cat species be called M. felis and M. gateae, respectively.


Occurrence of hyperthyroidism in patients receiving thyroid hormone.


Bilateral exophthalmos in seminoma.

Bilateral exophthalmos in seminoma.


The dependence of cold agglutinin activity on K chains.


Observations on the lipolytic activity of human serum and pituitary fractions in vitro.


Evaluation of light chain antigen binding by radioimmunoelectrophoresis.


Studies on the induction of immunologic unresponsiveness. II. Kinetics.


Cryosurgery of the prostate: a preliminary report.


Cytocidal action of colchicine in vitro on lymphocytes in chronic lymphocytic leukaemia.


Diagnosis: the clinician and the computer.


Antigenicity in mice of antilymphocyte gamma-globulin.


Effect of mixtures of atabrine and antibacterial agents on the emergence of resistant strains of Mycobacterium tuberculosis.


Two structurally distinct classes of kappa-chains in human immunoglobulins.


Balanced synthesis of light and heavy chains of immunoglobulin G.


Phylogenetic differences among the Gm factors of non-human primates.


Concanavalin A reaction with human normal immunoglobulin G and myeloma immunoglobulin G. Concanavalin A precipitated less than 5 percent of immunoglobulin G from human serum. It reacted with all of 42 myeloma serums of the immunoglobulin G type tested, but no more than approximately 50 percent of the total myeloma protein was ever precipitated. The fact that not all of the protein was precipitated and that the amounts precipitated varied from serum to serum may be interpreted as demonstrating heterogeneity of the carbohydrate in these myeloma proteins. Other glycoproteins precipitated by concanavalin A were identified, and subsequently separated from concanavalin A by chromatography.


The anovular  corpus luteum in the golden hamster [Mesocricetus auratus Waterhouse) and comparisons with the normal corpus luteum and follicle of atresia.


Synthesis of beta-1E and beta-1C components of complement in human foetuses.


An improved method for the histochemical demonstration of phosphorylase in tissue sections.


Paroxysmal nocturnal hemoglobinuria. Report of a case with refractory megaloblastic-hypoplastic bone marrow, bizarre erythrocyte morphology, and a positive Coombs' test.


Chemical characterization of the peptic fragment of rabbit gamma-G-immunoglobulin.


Endometrial carcinoma of proxtatic utricle (uterus masculinus).


Vaginal cytology as an aid to hormone therapy in postmenopausal cancer of the breast.


Divalent 4.5 S fragment of rabbit gamma-G-immunoglobulin antibody obtained by tryptic hydrolysis.


Canine leishmaniasis in the U.A.R.

Canine leishmaniasis in the U.A.R.


The influence of the microbial flora on liver injury and associated serum gamma-globulin elevation. A study in germ-free rats treated with 3'-methyl-4-dimethylaminoazobenzene.


Agricultural poisons.

Agricultural poisons.


Hypothyroidism following treatment of thyrotoxicosis with radioiodine.


Organochlorine pestidices in Antarctica.


Immunoglobulins in Tibetans.

Immunoglobulins in Tibetans.


Effect of anti-rat lymphocyte antibody on humoral antibody formation.


Post-embedding staining with ferritin labelled antibodies.


Transneuronal cell degeneration in the olfactory bulb shown by the Golgi method.


Multiple myeloma without a paraprotein. Report of a case with observations on chromosomal composition.


Accumulation of newly synthesized RNA templates in a unique class of polyribosomes during embryogenesis.


Renal vein thrombosis and the nephrotic syndrome. Immunofluorescence studies.


The antibody deficiency syndrome. Clinical considerations.


Mercaptopurine hepatotoxicity in a patient with chronic active hepatitis.


Children with communication problems: how does one evaluate them?


A new immuno-electron microscope technique with use of metal chelate antibody (MCA).


Cartilage matrix depletion by rheumatoid synovial cells in tissue culture. Articular cartilage fragments were added to monolayer cultures of synovial membrane cells. After 3 wk of incubation, the cartilage fragments were examined histologically for metachromasia and basophilia, and for fluorescent staining using a rabbit antiserum to cartilage protein-polysaccharide. Cartilage incubated with cells derived from rheumatoid synovial membranes showed striking loss of metachromasia and basophilia as well as diminished to absent fluorescent staining. Cartilage fragments incubated with cells from normal synovia, or with cells from the synovial membrane of a patient with Reiter's syndrome, did not show these changes and resembled control cartilage incubated in tissue culture medium alone. It appears, therefore, that rheumatoid synovial cells in tissue culture are able to deplete the matrix of articular cartilage.


Sequential changes in the relative affinity of antibodies synthesized during the immune response. The anti-2,4-dinitrophenyl (DNP) antibodies synthesized by suspensions of lymph node cells obtained at various intervals from rabbits that had been immunized with DNP-bovine gamma-globulin increased progressively in their affinity for the dinitrophenyl determinant. This change accompanied and was apparently responsible for a similar change in the binding properties of anti-DNP antibodies isolated from the serum. The rate of change in affinity was related to the dose of immunogen: increasing the dose delayed the change. The antibodies formed during a brief (5 hr) incubation in vitro were heterogeneous in their binding properties. Therefore, the mixing in the circulation of molecules synthesized at different times may contribute to, but is not alone responsible for, the heterogeneity in the serum antibodies. Variability in binding did not appear to be related to heterogeneity in immunoglobulin class. Indeed, the variations in relative affinity occurred entirely within the gammaG-immunoglobulins.


Renal transplantation in the inbred rat. 3. A study of heterologous anti-thymocyte sera. Heterologous rabbit anti-rat thymocyte sera, its immunoglobulin G fraction, and the bivalent and univalent antibody fragments obtained by pepsin digestion are potent immunosuppressive reagents when tested in a system of renal allotransplantation between the LBN F(1) hybrid and Lewis rat strains. The AT F(ab')(2) is not lymphocytotoxic in vitro but has agglutinating ability, while the AT Fab' neither agglutinates nor is cytotoxic to rat lymphocytes, but will inhibit the in vitro reaction. The AT IgG and the F(ab')(2) are more immunogenic in their host than normal rabbit IgG and F(ab')(2), probably due to increased delivery of the antibody to the immune system. Donor pretreatment studies demonstrate that a cross-reacting, highly immunogenic antibody with anti-lymphocyte specificity may bind to renal sites and be transferred to the new host after transplantation. In addition, the crude unabsorbed anti-thymocyte antisera may induce a nephritis characteristic of immune complex disease which can be eliminated by complete absorption with serum proteins. Further in vivo and in vitro evidence is presented that the AT IgG contains small amounts of antibody to glomerular basement membrane antigens and may induce an autologous phase-nephrotoxic nephritis. The amount of in vivo binding by AT IgG to GBM was reduced by subcutaneous rather than intravenous administration. Most of the rabbit antisera tested contain antibody in low titer to sheep erythrocytes and in vivo experiments indicate that the nature of the immunodepressive effect of AT globulin to sheep erythrocytes is due in part to the passive transfer of antibody and is not necessarily due to a specific anti-lymphocyte effect.


The relative affinity of antibodies synthesized in the secondary response. In response to a second injection of rabbits with a dinitrophenylated antigen, given 2 months to 2 yr after the first injection, there was rapid synthesis of large amounts of antibody high in relative affinity for the dinitrophenyl (DNP) determinant. The antibodies formed 3 days after restimulation were already high in affinity. Amounts of antigen too small to elicit detectable antibody production may prime the animal for a partial secondary response characterized by the formation of antibody of intermediate affinity after a second antigenic stimulus. Investigations into the specificity requirements for the secondary response indicated that variation in the carrier protein and in the haptenic determinant could be tolerated. Thus, after immunization with DNP-bovine gamma-globulin, DNP-hemocyanin elicited the vigorous production of high affinity anti-DNP antibodies. However, DNP serum albumin was much less effective: it elicited a secondary response in some animals primed with DNP-bovine gamma-globulin only when the interval between injections was increased from 10 to 28 wk. A secondary response was also evoked when the haptenic determinent of the second immunogen differed slightly from that of the one injected initially (i.e., 2,4,6-trinitrophenyl versus 2,4-dinitrophenyl).


Phosphotungstic acid stain and epidermal cell surface. An electron microscopic study.


Immediate reaction to penicillin. Association with penicilloyl-specific skin-sensitizing antibodies and low titers of blocking (IgG) antibodies.


The effects of endotoxin on the immune response in the rat. 3. Elimination of I125-labeled bovine gamma-globulin from the circulation of rats.


Histochemical and biochemical studies of strain L fibroblasts treated with a lathyrogen. Increased synthesis of polysaccharides.


Pernicious anaemia as a cause of infertility.


A new method for detection and measurement of intrinsic-factor antibodies.


Adrenaline in bronchial asthma.

Adrenaline in bronchial asthma.


Aminophylline in bronchial asthma.

Aminophylline in bronchial asthma.


Pathogenesis of the acute renal failure associated with incompatible transfusion.


Measurement of body water and intracellular electrolytes by means of muscle biopsy.


Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis.


Tryptophan in the treatment of depression.


Antibodies to synthetic human gastrin I.


A comparison of the effects of insulin hypoglycaemia and arginine infusion on release of human growth hormone.


Chemoprophylaxis against tuberculosis.

Chemoprophylaxis against tuberculosis.


Thyrotoxicosis.

Thyrotoxicosis.


Foot-and-mouth disease.

Foot-and-mouth disease.


Intrinsic-factor antibodies.

Intrinsic-factor antibodies.


Appointment systems in general practice.


Administration and the general practitioner.


Temporary registration and requalification.


Dangers of L.S.D.

Dangers of L.S.D.


The functional overlay.

The functional overlay.


Exposure of skin-grafts.

Exposure of skin-grafts.


Glucose and serum-triglycerides.

Glucose and serum-triglycerides.


Calcium and magnesium and renal stones.

Calcium and magnesium and renal stones.


Lead in drinking water.

Lead in drinking water.


Trisomy 18 and neonatal hypoglycemia.

Trisomy 18 and neonatal hypoglycemia.


Bovine Burkitt's lymphoma.

Bovine Burkitt's lymphoma.


Malaria--recent progress and problems.

Malaria--recent progress and problems.


Fast potential spike of frog skin generated at the outer surface of the epithelium. Experiments were performed to test which structure of frog skin epithelium is responsible for the electrical excitation (fast, all-or-none potential spike) displayed by this tissue during stimulation with a current pulse. Preselected cells of the outer epithelial surface were punctured by microelectrodes under microscopical observation. The major part of the transepithelia resting resistance and the major part of the spike were recorded between microelectrode tip and outside bathing solution. A leak between microelectrode and punctured membrane is made responsible for the attenuation of spike amplitude observed under these recording conditions. It is shown that if the spike is generated at but one of the series membranes of the epithelium, this membrane must be at the outermost border of the tissue.


Relationship between growth phase and conjugation efficiency in Escherichia coli K-12.


The thermal shrinkage process of collagen fibres as revealed by polarization optical analysis of topooptical staining reactions.


Isolation and some properties of reduced diphosphopyridine nucleotide: 2,6-dichlorophenolindophenol soluble reductase from Mycobacterium phlei.


Ultrastructural changes of collagen fibres in wheals produced by intracutaneous injection of different substances in the rat.


Prevention and control of experimental atherosclerosis in the rabbit. A biological factor.


Periodic thymidine kinase production in synchronous plasmodia of Physarum polycephalum: inhibition by actinomycin and actidion.


Papillary "tumours" of the left ventricle.


Surgical treatment of the Fallot's tetralogy.


A case report of pituitary tumor presenting as Forbes-Albright syndrome: determination of pituitary prolactin content.


Polycyclic aromatic hydrocarbons formed by pyrolysis of carbohydrates, amino acids, and fatty acids.


Regression of the intrinsic nerves and other sequelae with reimplantation of the lung.


Lupus erythematosus cell (LE-cell) test without a blood clot.


Studies in myasthenia gravis. 2. The relation of some clinical and immunological data.


Real chromatid deletions versus gaps.

Real chromatid deletions versus gaps.


The cell types in the endocrine pancreas of the human fetus.


Histological and submicroscopic studies on arteriolar hyalinosis of the human testis.


Morphological changes and radiosensitivity of mouse oocytes.


Orthogonal phase relations in the EEG.

Orthogonal phase relations in the EEG.


Absence of beta-globin synthesis and excess of alpha-globin synthesis in homozygous beta-thalassemia.


The renal effect in vitro of different irrigating fluids used in transurethral surgery.


Separation of malarial parasites according to age by density gradient centrifugation.


Characterization of the serum immunoglobulins to the somatic antigen of S. typhosa in an infant following intrauterine immunization.


Familial granulocytopenia and associated immunoglobulin abnormality. Report of three cases in young brothers.


A new method of active immunisation to autologous human tumour tissue.


Structural differences within the gamma G class of immunoglobulins.


Relative efficiency of immune cytolysis by IgG and IgM antibodies.


Histochemistry of the mucosaccharides in the epiphyseal plate of young rabbits.


Release of histamine and slow reacting substance with mast cell changes after challenge of human lung sensitized passively with reagin in vitro.


Concentration of immunoglobulins in lethally x-irradiated mice.


Cerebellum of mormyrids.

Cerebellum of mormyrids.


Longitudinal differentiation of the small intestine.


Mast cells free of histamine in Rana catasbiana.


Haptoglobins, transferrins and serum gamma-globulin types in Malayan aborigines.


Suppression of the primary Rh immune response with passive Rh IgG immunoglobulin.


Increased protein-bound iodine and thyroxine-binding globulin in acute intermittent porphyria.


Lissamine green--a supravital stain for determination of corneal endothelial viability.


Electron microscopy of classically stained astrocytes.


The symbolization of logical relationships in a line-drawing medium.


Serum level of the fourth component of complement in various diseases.


Circulatory and respiratory adaptation during prolonged exercise.


Tools to evaluate child development.

Tools to evaluate child development.


Survival of patients with small carcinomas of the head of the pancreas. Biliary-intestinal bypass vs. pancreatoduodenectomy.


Benign hypertrophy of the masseter muscles associated with hypofibrinogenaemia. A case report.


Gamma-M deficiency predisposing to meningococcal septicaemia.


The influence of actinomycin on early embryonic development.


Number, volume, surface and inner strcture of the rat liver cells nucleoli.


Acid-soluble nuclear proteins in developmental stages of Lytechinus variegatus.


In vitro culture of large areas of membranous biological structures.


Evidence for a subpopulation of cells with an extended G2 period in normal adult mouse liver.


Variable sensitivity of starfish ovarian tissue to radial nerve factor.


Isolation of microfilaments from Amoeba proteus.


In vivo studies on the optimum time for the action of colchicine on mouse lymphoid tissue.


Electrophoresis of sperm-absorbed univalent sea urchin fertilizin.


Synchronized cell division induced by medium change.


Tumor cell-tumor cell emperipolesis.

Tumor cell-tumor cell emperipolesis.


Unusual intra-cellular bacterial infection in large, free-living amoebae.


Fertilization membranes structure analysis with the surface replica method.


Viability studies on megakaryocytes in mechanically and enzymaticlly suspended rat bone marrow.


Mitosis of bi- and multinucleate HeLa cells.


Macronuclear chromatin structure in Euplotes.


Criteria for biologic evaluation of anterior tooth filling materials.


Intracellular changes in cells of Escherichia coli infected with a filamentous bacteriophage.


Interferon production and viral ribonucleic acid synthesis in chick embryo cells.


The cytopathic effects of HGP virus and Coxsackievirus B type 5 on HEp2 cells.


Chemical structure of African swine fever virus investigated by electron microscopy.


Cytological examination of the sputum.

Cytological examination of the sputum.


Radioimmunoassay for determining plasms-levels of angiotensin II in man.


"Arterialization" and "venization" of vessels involved in traumatic arteriovenous fistulae: aetiology and pathogenesis. (An experimental study).


Measurement of angiotensin II in blood.

Measurement of angiotensin II in blood.


Fibrinolytic effects of diguanides plus ethyloestrenol in occlusive vascular disease.


Reduction of platelet stickiness by phenformin plus ethyloestrenol.


Isotope encephalography in the diagnosis of dementia due to communicating hydrocephalus.


Faecal excretion of lead by children.

Faecal excretion of lead by children.


Plasma-zinc concentrations in patients with psoriasis, other dermatoses, and venous leg ulceration.


Changes in plasma levels of insulin and growth-hormone levels after a protein meal.


New schools in Africa.

New schools in Africa.


The nature of the neuropathy complicating acute intermittent porphyria.


Acute respiratory failure in asthma.

Acute respiratory failure in asthma.


Medicine in Zambia.

Medicine in Zambia.


Experience of multiple-choice-question examination for part I of the M.R.C.P.


Termination of pregnancy by vacuum aspiration.


A method for concentrating cancer cells in sputum.


Glucose tolerance and diabetes in chronic liver disease.


A seven-year field trial of two typhoid vaccines in Guyana.


Influence of neomycin sprays on the spread of resistant staphylococci.


Pituitary-adrenal function after occlusive topical therapy with betamethasone-17-valerate.


Cytomegalovirus infection associated with pregnancy.


Surgace IgM specificity on cells derived from a Burkitt's lymphoma.


Is lysergic-acid diethylamide a teratogen?


Steroid hormones and varicose veins.

Steroid hormones and varicose veins.


The immunologicial consequences of cell death.


Typhoid vaccines.

Typhoid vaccines.


Lead in drinking water.

Lead in drinking water.


Clinical pharmacology. Its role and its intergration into the education of the medical student.


Calcium metabolism after castration.

Calcium metabolism after castration.


Insulin and glucose response to glucagon in Down's syndrome.


Maurice Davidson.

Maurice Davidson.


Diagnosis of allergy by an in-vitro test for allergen antibodies.


Nature of the transferable factor which causes abnormal platelet behaviour in vascular disease.


Severe respiratory distress syndrome mimicking cyanotic heart-disease in term babies.


Symptomatic, radiological, and functional improvement following treatment of urinary schistosomiasis in Egypt.


The effect of postoperative infection on the anaemia of chronic inflammation.


Satellite-counts on mitotic chromosomes of monozygotic and dizygotic human twins.


Mycoplasmas and erythema multiforme.

Mycoplasmas and erythema multiforme.


Fatal human disease from vervet monkeys.


Experimental production of microangiopathic haemolytic anaemia in vivo.


Red-blood-cell fragmentation in microangiopathic haemolytic anaemia: in-vitro studies.


An electronically controlled bladder irrigator and tidal drainage apparatus.


Intracerebral haemorrhage and microaneurysms.


Affectional bonds and anxiety.

Affectional bonds and anxiety.


Disease transmitted from monkeys to man.


Advice on addiction.

Advice on addiction.


Rheumatic fever in approved schools.

Rheumatic fever in approved schools.


Influence of doctors' and patients' attitudes in the treatment of neurotic illness.


A critical look at antidepressant drug trials.


The right to a blood-test.

The right to a blood-test.


Haemopoietic stem cells in the peripheral blood.


Blood-test accepted as evidence.

Blood-test accepted as evidence.


Too much room for doubt.

Too much room for doubt.


Responsibility for casualties.

Responsibility for casualties.


A simple chromosome stain.

A simple chromosome stain.


Sex chromatin in female breast cancer.

Sex chromatin in female breast cancer.


Kuru, rainfall, and nutrition.

Kuru, rainfall, and nutrition.


Emptying the Kiil kidney.

Emptying the Kiil kidney.


Peritoneal dialysis in malaria.

Peritoneal dialysis in malaria.


What is a beta-blocker?

What is a beta-blocker?


Verapamil and cardiac pain.

Verapamil and cardiac pain.


Acid mucopolysaccharides and atherosclerosis.


Pyridoxine treatment in homocystinuria.

Pyridoxine treatment in homocystinuria.


Magnesium levels and thyroid disease.

Magnesium levels and thyroid disease.


Why Demosthenes mouthed pebbles?

Why Demosthenes mouthed pebbles?


Cytological examination of the sputum.

Cytological examination of the sputum.


Cytomegalovirus mononucleosis.

Cytomegalovirus mononucleosis.


Arthur John Hibbert Tomlinson.

Arthur John Hibbert Tomlinson.


Effect of phenyramidol and bishydroxycoumarin on the metabolism of tolbutamide in human subjects.


Linked groups of residues in immunoglobulin k chains.


Structure at the hinge region in rabbit immunoglobulin-G.


Carbohydrate supply as a regulator of rat liver phosphoenolpyruvate carboxykinase activity. Administration of glucose, fructose, and glycerol to fasted rats produced a significant depression of liver phosphoenolpyruvate carboxykinase activity within 4 to 8 hours; galactose and ribose were much less effective. All the compounds yielded appreciable quantities of liver glycogen. The depression of phosphoenolpyruvate carboxykinase activity by glucose and glycerol was diminished by the concomitant administration of 2-deoxyglucose. The latter depressed glycogen formation from administered carbohydrate in muscle but not in liver. In rats made diabetic by alloxan, depression of elevated phosphoenolpyruvate carboxykinase activity by insulin was dependent upon a dietary source of carbohydrate. These results were interpreted to indicate that depression of certain gluconeogenic enzymes after carbohydrate ingestion is initiated by the metabolism of carbohydrate in some extrahepatic site.


Red cells coated with immunoglobulin G: binding and sphering by mononuclear cells in man. Human monocytes, macrophages, and certain lymphocytes bind firmly to red cells coated with immunoglobulin G, whether or not it is acting as antibody. Monocyte binding is specific for cells coated with immunoglobulin G and is inhibited specifically by this immunoglobulin or its Fc-fragment in solution. Although not involving serum complement and not usually a prelude to erythrophagocytosis, this binding causes rapid morphological injury to red cells, as manifested by their sphering, increased osmotic fragility, deformation, and fragmentation. It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed.


Multiple myeloma.

Multiple myeloma.


Histochemical study of the oxidative enzymes in the olfactory bulb of the rat.


Studies on the elastolytic activity of serum.


On the direct effect of cobalt on nucleic acid and protein metabolism in rat's bone marrow cultivated in vitro.


Pathogenesis of prostatic hyperplasia and neoplasia.


Positive direct Coombs tests and antinuclear factor in patients treated with methyldopa.


Decreased taste sensitivity after D-penicillamine reversed by copper administration.


Erythropoietin and hepatoma.

Erythropoietin and hepatoma.


Screening tests for growth-hormone deficiency in dwarfism.


Results of treatment of progressive lesions in spina bifida occulta five to ten years after laminectomy.


Chemical aspects of amyloid-Congo red binding.


Induction of antibody formation and tolerance in vitro to a purified protein antigen.


Primary immune response in cultures of spleen cells.


Bedsores.

Bedsores.


Site of action of antilymphocyte globulin.


Mysterious sarcoma.

Mysterious sarcoma.


Sequelae to pulmonary embolism.

Sequelae to pulmonary embolism.


Tonsillectomy.

Tonsillectomy.


Werner's syndrome.

Werner's syndrome.


Intensive care.

Intensive care.


Social medicine and management.

Social medicine and management.


Cervical carcinoma. The beginning of the end?


The thymus. Yesterday, today, and tomorrow.


Venous stasis and fibrinolysis.

Venous stasis and fibrinolysis.


Pernicious anaemia and infertility.

Pernicious anaemia and infertility.


Folic acid and neuropathy in epilepsy.

Folic acid and neuropathy in epilepsy.


Cannabis in early pregnancy.

Cannabis in early pregnancy.


Is lysergide a teratogen?

Is lysergide a teratogen?


Deleted chromosome 18 with paternal mosaicism.


Sex chromatin in rat bone-marrow cells.

Sex chromatin in rat bone-marrow cells.


Survival after imipramine poisoning.

Survival after imipramine poisoning.


Sex-chromatin values in rat epithelium.

Sex-chromatin values in rat epithelium.


Cephaloridine toxicity.

Cephaloridine toxicity.


Prolonged total fasting for obesity.

Prolonged total fasting for obesity.


A new method for inducing hypothermia.

A new method for inducing hypothermia.


Septal and arterial shunts in tricuspid atresia.


Enzyme activity in de Lange's syndrome.

Enzyme activity in de Lange's syndrome.


Hypoglycaemic effect of trigonelline.

Hypoglycaemic effect of trigonelline.


A Hurler's syndrome variant.

A Hurler's syndrome variant.


Specificity of the Ph1 chromosome.

Specificity of the Ph1 chromosome.


Small-intestinal diarrhoea.

Small-intestinal diarrhoea.


Glucose absorption in coeliac disease.

Glucose absorption in coeliac disease.


Micropuncture and histologic study of submaxillary glands of young rats.


Advances in the treatment of tuberculosis.


Protein deficiency in temperate zones.

Protein deficiency in temperate zones.


Relationship of nitrogen oxides in auto exhaust to eye irritation--further results of chamber studies.


Lead from auto exhaust: effect on mouse bone lead concentration.


"Clean catch" urines in the newborn--bacteriology and cell excretion patterns in first week of life.


Nature of organic iodinated compounds in the circulation of euthyroid and hyperthyroid subjects stimulated with porcine thyrotrophin.


Development of thyroidal suppression by triiodothyronine during six months' treatment of thyrotoxicosis with antithyroid drugs.


Etiology and treatment of hyperthyroidism in the adult.


Studies on the mechanisms of hypersensitivity phenomena. XV. Enhancement of passive sensitization of human leukocytes by heparin.


Studies on the mechanisms of hypersensitivity phenomena. XVI. In vitro assays of reaginic activity in human sera: effect of therapeutic immunization on seasonal titer changes.


Inhancement activity of mouse immunoglobulin classes.


Studies on the immunoglobulins which stimulate the ingestion of glutaraldehyde-treated red cells attached to macrophages.


The role of antibody bivalence in the neutralization of bacteriophage.


A stoichiometric assay for the fourth component of complement in whole human serum using EAC'la-gp and functionally pure human second component.


Identification of gamma-E-antibodies as a carrier of reaginic activity.


Immunochemical quantitation of the third, fourth and fifth components of human complement: concentrations in the serum of healthy adults.


Phylogeny of immunoglobulin structure and function. II. Immunoglobulins of the nurse shark.


Antibody concentration and temperature as determinants of in vitro sensitization and histamine release in isolated cardiac tissues.


Crystalloid structure in the microbodies of plant embryo cells.


Histopathological studies of malignant lymphoma and leukemia with lipid staining.


Evaluation of hydroxyprogesterone caproate in the treatment of benign prostatic hyperplasia.


Current concepts in the management of hemolytic disease of the newborn.


The subcellular fractionation of the electric organ of Torpedo.


Immune response and changes in gammaglobulins in thymectomized and/or appendectomized rabbits.


Carcinogens, enzyme induction, and gene action.


Studies on the mode of action of vitamin K.


Extra-adrenal endocrine deficiencies in Addison's disease.


Clinicopathologic Conference. Chronic lymphocytic leukemia complicated by disseminated histoplasmosis.


Isozymes of aspartate aminotransferase in tissues and blood of man.


Macroglobulinemia and vasculitis in Sjögren's syndrome. Experimental observations relating to pathogenesis.


Blood lead of persons living near freeways.


Relation of pesticide concentrations in fat to pathological changes in tissues.


Antibodies to the carboxyl-terminal tetrapeptide of gastrin.


Fixation of aortic valve homografts with metal rings.


Pulmonary lymphatic drainage.

Pulmonary lymphatic drainage.


The role of functional demand on the development of pulmonary lesions during hemorrhagic shock.


Palliation for malignant esophagotracheal fistula.


Effects of beta-adrenergic blockade during exercise in hypertensive and ischaemic heart-disease.


Coronary-artery disease in hypothyroidism.


Oesophageal atresia.

Oesophageal atresia.


Autoimmune disease and chromosomal instability.


Severe systemic infections complicating "mainline" heroin addiction.


Prednisolone metabolism and rheumatoid arthritis.


Effect of aerosol isoprenaline on blood-gas tensions in severe bronchial asthma.


An inexpensive and safe blood-warming unit.


Endothelium and atherosclerosis.

Endothelium and atherosclerosis.


Power or persuasion?

Power or persuasion?


Nephrology.

Nephrology.


Diversity of living organisms.

Diversity of living organisms.


Sympathomimetic drugs in asthma.

Sympathomimetic drugs in asthma.


Referred pain.

Referred pain.


The hospital clinician's role, from two standpoints. 2. As a hospital administrator sees it.


Virus-induced antigen.

Virus-induced antigen.


Immunisation against human tumours.

Immunisation against human tumours.


Lymphocytes in Epidermophytosis.

Lymphocytes in Epidermophytosis.


Corticotrophin and platelet stickiness.

Corticotrophin and platelet stickiness.


The "at risk" infant.

The "at risk" infant.


Treatment of hypercalcaemia.

Treatment of hypercalcaemia.


Pituitary-adrenal function after topical steroids.


Serum-Hepatitis from frozen blood.

Serum-Hepatitis from frozen blood.


Evaluating antidepressant drug trials.

Evaluating antidepressant drug trials.


Diazepam in labour.

Diazepam in labour.


Effects of beta-blockade on coronary flow.


Coronary-artery disease in myxoedema.

Coronary-artery disease in myxoedema.


Hyperosmolar non-ketotic coma.

Hyperosmolar non-ketotic coma.


Lead in dringking water.

Lead in dringking water.


Serologic factors in human transplantation.


The thyroid and fibrinolysis.

The thyroid and fibrinolysis.


Response of men with advanced prostatic carcinoma to exogenous administration of testosterone.


Appearance of Hodgkin's disease in a patient with systemic lupus erythematosus.


Significance of obtaining four phases of sleep in children.


Development of retinal vessels in the rat.


Immunochemical studies on taka-amylase A. Kinetic studies on the inhibition of amylase activity by anti-taa antibody.


The fine structure of Chondrococcus columnaris. 3. The surface layers of Chondrococcus columnaris. An electron microscope study of the myxobacterium Chondrococcus columnaris has revealed the following structures in the peripheral layers of the cells: (1) a plasma membrane, (2) a single dense layer (probably the mucopeptide component of the cell wall), (3) peripheral fibrils, (4) an outer membrane, and (5) a material coating the surfaces of the cells which could be stained with the dye ruthenium red.The ruthenium red-positive material is probably an acid mucopolysaccharide and may be involved in the adhesive properties of the cells. The outer membrane and plasma membrane both have the appearance of unit membranes: an electron-translucent layer sandwiched between two electron-opaque layers. The peripheral fibrils span the gap between the outer membrane and the mucopeptide layer, a distance of about 100 A, and run parallel to each other along the length of the cell. The fibrils appear to be continuous across the ends of the cells. The location of these fibrillar structures suggests that they may play a role in the gliding motility of these bacteria.


Intestinal lymphangiectasia: a protein-losing enteropathy with hypogammaglobulinemia, lymphocytopenia and impaired homograft rejection. Intestinal lymphangiectasia is a disease characterized by dilated intestinal lymphatics, protein-losing enteropathy, hypoalbuminemia, and edema. The immunologic status of 18 patients with intestinal lymphangiectasia was studied. Concentrations of IgG, IgA, and IgM were measured by immune precipitation and metabolism of these three immunoglobulins was studied using purified radioiodinated proteins. The serum concentration and total body pool of each immunoglobin were greatly reduced. The fraction of the intravascular protein pool catabolized per day was increased to 34% for IgG, 59% for IgA, and 66% for IgM; these are in contrast with control values of 7%, 28%, and 17%, respectively. Synthetic rates of the immunoglobulins were normal or slightly increased. Primary circulating antibody response was tested in five patients with Vi and tularemia antigens. Titers elicited in patients with the Vi antigen were significantly lower than those seen in a control group, whereas no difference was seen between patient and control responses to the tularemia antigen. Lymphocytopenia was noted in patients with intestinal lymphangiectasia. The mean circulating lymphocyte count was 710 +/- 340/mm(3) in contrast to 2500 +/- 600/mm(3) in controls. Cellular hypersensitivity was studied with skin tests and skin grafts. 91% of normal individuals reacted to at least one of the four skin test antigens: purified protein derivative, mumps, Trichophyton, and Candida albicans; in contrast, only 17% of patients with intestinal lymphangiectasia had a positive reaction. Each of three patients tested with dinitrochlorobenzene had a negative reaction. Finally, all four patients who received skin homografts have retained these grafts for at least 12 months. The immunological disorders in patients with intestinal lymphangiectasia appear to result from loss of immunoglobulins and lymphocytes into the gastrointestinal tract secondary to disorders of lymphatic channels. Lymphocyte depletion then leads to skin anergy and impaired homograft rejection.


The relation of immunoglobulin class, pattern of anti-nuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. Sera from 55 patients with systemic lupus erythematosus were studied to clarify the significance of the patterns of nuclear fluorescence observed. The sera in which the IgG fraction produced a peripheral pattern of nuclear fluorescence were found to contain complement-fixing antibodies to native DNA and to DNA-histone complexes. This correlation did not exist when complement-fixing activity was compared to the IgM nuclear patterns. Sera which contained only complement-fixing antibodies to denatured DNA and which did not react with native DNA or nucleoprotein did not produce the peripheral pattern of nuclear fluorescence. The data suggest that single strands of DNA were not the reactive groups in the nucleus responsible for the peripheral pattern. The results support the conclusion that DNA within a DNA-protein complex may be the nuclear antigen responsible for the peripheral pattern of nuclear fluorescence. Analysis of the clinical data revealed that a close correlation existed between the presence of IgG peripheral pattern, complement-fixing antibodies to DNA and histone-DNA complexes, and clinical manifestation of active disease.


Mouth ulcers associated with prolonged chewing of gum containing aspirin.


Some clinical aspects and treatment of anonymous mycobacterial infections.


Plasma lipoproteins in liver disease. I. Immunologically distinct low-density lipoproteins in patients with biliary obstruction. Sera from patients with extrahepatic biliary obstruction were found to have an abnormal lipoprotein (obstructive lipoprotein) which failed to react with antibodies to normal lipoproteins of d < 1.063. Preparations of this abnormal lipoprotein made by a combination of immunoprecipitation and multiple polyanion precipitations revealed a high content of free cholesterol (26%) and phospholipids (61%) but only trace amounts of cholesterol esters and triglycerides. Protein content varied from 13% to a corrected low of 5% when ultracentrifugation was also performed. Amino acid analyses of the latter preparations resembled that of lipoproteins of d < 1.006. The reasons underlying the apparent unreactivity of the abnormal lipoprotein were explored. No evidence could be found for soluble antigen-antibody complexes of gamma-globulin and the abnormal lipoprotein, nor for inhibition of antigen-antibody complex formation by serum factors. Purified preparations of obstructive lipoprotein did not react with antisera to high- or low-density lipoproteins prepared from normal sera. Moreover, rabbits immunized with the abnormal lipoproteins produced specific antibodies to this lipoprotein which reacted with a d < 1.006 lipoprotein in normal sera. All other lipoprotein fractions from normal sera were unreactive. It is not known whether this lipoprotein is abnormal by virtue of the presence of a unique peptide or because of secondary alterations in lipoprotein structure.


Autonomy of H-2 genes in individual immunocytes.


Metabolism of labelled carcinogenic hydrocarbons in rats.


Reconstitution of elastin.

Reconstitution of elastin.


Sex-linked hereditary thrombocytopenia as a variant of Wiskott-Aldrich syndrome.


Multiple myeloma associated with two serum M components, gamma-G type K and gamma-A type L.


Bitypic gammopathy.

Bitypic gammopathy.


Conformational change and complementarity in the combination of H and L chains of immunoglobulin-G.


5-oxo-5H-benzo[e]indole, a new type of highly sarcomagenic lactone. The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.


Studies of rheumatoid pulmonary disease. II. "Intermediate" protein components in the sera of patients with rheumatoid arthritis with simultaneous pleuropulmonary lesions.


Fetal immunoglobulins: immunofluorescent identification and localization in bone marrow.


Immunoglobulins--town and gown--the American Board.


The clinical significance of plasma thyroid-stimulating activity in hyperthyroidism.


Neonatal thyrotoxicosis: report of three cases involving four infants.


Sensori-neural deafness of peripheral origin.


Recurring middle ear infection and serum proteins in children.


Studies on the nervous system of Tetrathyridia (Cestoda: Mesocestoides).


Carcinoma of the colon in the old and young.


Prevention of Rh-haemolytic disease.

Prevention of Rh-haemolytic disease.


The pharmacology of heparin and heparinoids.


The histidine decarboxylases.

The histidine decarboxylases.


Replication of SV5 RNA and the effects of superinfection with poliovirus.


Argyrophile and argentaffin reactions in individual granules of enterochromaffin cells of the guinea pig.


Myeloarchitectonics of the septum in the brain of the dog.


Microtubules in human aortic intimal cells.


Myeloarchitectonics and connections of substantia innominata in the dog brain.


Ultrastructural changes during zoospore formation in phytophthora parasitica.


Quantitative cellular fluorimetry: I. Effect of in vitro thioacetamide exposure on fluorescence of mammalian cell lines.


Febrile mucocutaneous syndromes (ectodermosis erosiva pluriorificialis, Stevens-Johnson's syndrome etc.) in adenovirus infections.


Cobalt contact dermatitis.

Cobalt contact dermatitis.


Occupational dermatitis from hydrazine hydrate used in boiler protection. Cross sensitization to apresoline, isoniazid and phenelzine.


The mechanism of action of the skin photosensitizing furocoumarins.


Prurigo simplex subacuta. A group of cases with atopic background.


Clinical features of sarcoidosis in Lebanon.


Pellagra-like syndrome associated with isoniazid therapy.


Electron microscopy of Merkel's "Tastzelle", a potential monoamine storing cell of human epidermis.


Quantitative analysis of epidermal lipids by thin-layer chromatography with special reference to seasonal and age variation.


Influence of nutrition and light on the peroxide content of the skin surface lipids of rats.


CRST syndrome and variant.

CRST syndrome and variant.


Early formation of keratohyalin granules in rat epidermis.


Changes in the temporomandibular joint in psoriasis arthropathica.


Treatment of plantar warts with cytostatics.


Perilesional leucoderma in metastatic melanoma. The use of the Wood's light for early detection of this rare reaction.


Lichen myxoedematosus in an eight year old boy.


Condylomata acuminata--past and present.


Localization and content of histamine in normal and diseased skin.


The effect of an intraperitoneally applied p-methoxyphenethylmethylamine-formaldehyde compound on the mast cell count in the skin of the rat's ear.


Cell proliferation in epidermis during the development of contact reactions as revealed by autoradiography after injection of thymidine-H3. 1. The epithelial cells.


Cell proliferation in epidermis during the development of contact reactions as revealed by autoradiography after injection of thymidine-H3. 2. The lymphoid cells.


Seasonal variations in contact dermatitis.


Twelve years of sensitization to neomycin in Finland. Report of 1760 cases of sensitivity to neomycin and-or bacitracin.


Utereotrophic effect of topically applied estradiol-17-beta-benzoate.


Effect of dimethyl sulfoxide on skin. A macroscopic and microscopic investigation on human skin.


Eccrine spiradenoma.

Eccrine spiradenoma.


Studies on embryo-specific proteins. Physiological characteristics of embryo-specific alpha-globulin.


A simple method for angio- and histoangiography.


Influence of short-term alcohol consumption on the excretion of some components of the vitamin-B group in the urine of rats.


The nucleus lateralis tuberis in the fresh water teleost, Clarias batrachus Linn.


A rapid method for staining thin sections of vestopal W-embedded tissue for light microscopy.


Conditioned activity depression in hypothyroid and hyperthyroid rats.


The chemotherapy of virus diseases.

The chemotherapy of virus diseases.


Silver-shadowing of giant salivary gland chromosomes.


Kerr effect study of the aqueous solutions of three globular proteins.


Experimental neuromorphological analysis of secondary degeneration of nerve bundles, its morphological appearance and dynamics. II. The time course and appearance of secondary degeneration in the pyramidal tract of the rat.


A contribution to the cytology of the carotid body.


Preparing surgical technicians.

Preparing surgical technicians.


An evaluation form for the O.R. technician.


Management of Rh disease.

Management of Rh disease.


The role of a developmental paediatrics centre.


Comparative study of phytotoxicity and cytological effects of dipterex and its O-methyl ether.


Neurosecretory activity in supraoptic nucleus of normal rats.


Membrane filters and microfilariae: a new diagnostic technique.


On the "red" character of a mutant of Newcastle disease virus (NDV).


The separation of protons and electrons as a fundamental biological process.


Brain research and behavioural activity.


Effect of specific antibodies on the excitability of internally perfused squid axons. Giant axons from the squid Dosidicus gigas were internally perfused with rabbit antiaxoplasm antibodies and their effect upon the action potential and the membrane potential was studied. Necessary requirements for the antibodies to affect these parameters in a consistent manner were: (a) removal of the bulk of axoplasm from the perfused zone, accomplished by initially perfusing with a cysteine-rich (400 mM) solution, and (b) addition of small amounts of cysteine (30 mM) to the antibody-containing solution. When these experimental conditions were met, conduction block ensued generally within 3 hr of the first contact of the axon inner surface with the antibody Antineurofilament antibodies and nonspecific antibodies had no effect. External application of antiaxoplasm antibodies had no effect.


Albumin, transferrin and gamma-globulin metabolism during lactation in the rat.


An observation of fine tubules within the endoplasmic reticulum in a dog liver.


On the distribution of the Gc variant Gc Aborigine in Melanesian populations; determination of Gc-types in sera from Tongariki Island, New Hebrides.


The distribution of Gc-types in selected populations from South-East Asia, Polynesia and Australia.


The effect of basic vital dyes on the acid phosphatase activity of the granulated juxtaglomerular cells.


Electron microscope observations of some forms of viral hepatitis. Contribution to the understanding of the morphological evolution and pathogenetic mechanism of jaundice.


Dysgammaglobulinaemia type IV C.

Dysgammaglobulinaemia type IV C.


Antigen-induced changes in lymphoid cell histones. 3. In vitro and in extract. Previous papers in this series have reported an acute, transitory effect of antigens on lymphoid cell nuclei. In the previous reports the effect was related to a change in ammoniacal silver (A-S) stainability of smears and cryostat sections. The variable substrate was identified as histone. This paper reports the results of an extended series of studies of histone and chromatin extracts from thymus glands exposed to antigen in vivo and in vitro. The antigen effect on A-S stainability is demonstrable not only in vitro but also in chromatin fibers representing a DNA-histone complex. However, it is not demonstrable in isolated histone fractions. The inference is drawn that the antigen-induced alteration in A-S stainability is brought about not by any quantitative change in histone, but by a biologically significant shift in histone binding, perhaps to DNA. It is suggested that alteration in DNA-histone binding during gene activation may alter A-S stainability of histones.


Dihydrofolic reductase in human blood cells. II. Enzyme activity after amethopterin and actinomycin C administration.


Antigen-induced changes in lymphoid cell histones. IV. Changes in solubility of isolated chromatin. In this study we have examined the solubility of deoxyribonucleoprotein (DNP) isolated from control and antigen-affected thymocytes. 2-M sodium chloride extracts containing the DNP of rat thymus glands were serially diluted. A comparison was made of the effect of dilution on fiber formation in the control and test series. Fiber formation is usually complete for the control material at a salt concentration between 0.63 and 0.57 M. The test material shows some fiber formation within this range. However, a significant portion of the DNP is precipitated at dilutions of 0.54-0.48 M. Ammoniacal silver (A-S) stains the control fibers a characteristic yellowish color. With the test material, those fibers formed within the control range tended to be stained yellowish brown by A-S, whereas those formed only after greater dilution stained blackish. These data, coupled with our previous observations on altered A-S staining, clearly demonstrate an antigen-induced physical and/or chemical alteration of the histone or histone-DNA complex of lymphoid cell chromatin.


Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae.


Differential identification of mycobacteria. 3. Use of thiacetazone, thiophen-2-carboxylic acid hydrazide, and triphenyltetrazolium chloride.


Seminal vesiculography in various prostatic diseases.


Four years' clinical experience with 138 kidney transplants.


Postoperative vesical neck contracture.

Postoperative vesical neck contracture.


Action of prilocaine on the vagus nerve and on adrenaline induced extrasystole in dogs.


Quantitative changes of ribonucleic acid (RNA), desoxyribonucleic acid (DNA), protein and dry matter in different organs of pea seedlings, during germination and cell elongation.


Splanchnic and general hemodynamics after acute hemorrhage in the anesthetized dog.


Effect of hyperpolarizing current on cardiac Purkinje fibres in K-enriched Tyrode.


Convergence of retinal and lateral line stimulation on tectum opticum and cerebellar neurones.


Human thyroglobulin: iodination and sedimentation rate.


Competitive inhibition of "in vitro" methane production by mixed rumen bacteria.


Phosphatases and esterases in the digestive gland of the crayfish "Orconectes virilis".


Iodide uptake studies on isolated thyroid cells.


Simultaneous intestinal transfer of D- and L- methionine in irradiated rabbits.


Subcellular structure of bovine thyroid. I. Beta-glucuronidase: a marker-enzyme for lysosomal particles.


RNA synthesis in rat liver after partial hepatectomy.


X-radiation induced disturbances of RNA metabolism in regenerating rat liver.


Ionic regulation of the haemolymph in the larvae of the dragonfly Ischnura elegans (Vanderlinden) (Odonata; Zygoptera).


The effect of biotin deficiency on the biosynthesis of the fatty acids in a blowfly, Aldrichina grahami during metamorphosis under aseptic conditions.


Esophageal motion during breathing.

Esophageal motion during breathing.


Dynamic parameters of myocardial contractility under influence of calcium and strontium.


Fatty liver induced by injection of L-tryptophan.


Alpha-oxidation as an alternative pathway for the degradation of branched-chain fatty acids in man, and its failure in patients with Refsum's disease.


Nucleotide metabolism in tissue culture cells at low temperatures. II. Feedback mechanisms during the synthesis of nucleoside and deoxynucleoside triphosphates at low temperatures.


The mechanism of the repression by inorganic phosphate of phytase synthesis in the germinating wheat embryo.


Antigenicity of 5-hydroxyindole-3-acetic acid, a derivative of serotonin. I. Preparation of protein conjugates of 5-hydroxyindole-3-acetic acid.


Antigenicity of 5-hydroxyindole-3-acetic acid, a derivative of serotonin. II. Antibodies specific to 5-hydroxyindoleacetic acid.


Detection of cells producing antibodies against the dinitrophenyl group.


A method for enhancing visualization of precipitin lines in agar analysis.


Radioimmunoassay for follicle-stimulating hormone (FSH) with 125-I-labeled FSH.


Fatal arrhythmias caused by the pressure of the ball-valve prosthesis upon the left ventricular myocardium.


Specific potentiation and its interaction with unspecific effects on the excitability cycle of the visual thalamo-cortical complex.


Tone cessation as a conditioned stimulus. II. Inhibition.


Amplitude relationships between evoked potential components during trace conditioning.


Effects of cerebellar stimulation on cobalt-induced epilepsy in the cat.


Spectrum analysis of residual EEG changes following post-natal x-irradiation in rats.


The variability of single evoked vertex potentials in man.


Semliki Forest virus effects on the rat central nervous system.


A solid state differential amplitude discriminator for single unit recording.


Selected trial averaging of sensory evoked brain responses.


An improved swivel for recording from behaving subjects.


Before the computer.

Before the computer.


Computers.

Computers.


A random function generator model for EEG signals.


The use of automated low frequency wave analysers in quantitative electroencephalography.


Automatic evaluation of EEG background activity.


EEG analysis using an analogue frequency analyser and a digital computer.


Magnetic tape recording in the EEG laboratory.


The EEG as a monitor of cerebral disturbance during fast and slow haemodialysis of patients in chronic renal failure.


Metrological preliminaries in quantification of the EEG.


Encoding verbal descriptions of data for computer processing.


The analysis, synthesis and identification of evoked responses and contigent negative variation (CNV).


The contingent negative variation (CNV) in a patient with spike and wave discharges evoked by photic stimulation.


EEG and limb tremor: an attempt to assess the contribution of cardiovascular factors to frequency content.


An investigation of pyramidal tract cells in the somatosensory cortex.


Observer bias in the measurement of motor unit potentials.


The EEG in three of Gjessing's patients with periodic catatonia.


The influence of medication and clinical state on the EEG in periodic endogenous depression.


Development of the contingent negative variation during the learning of a temporal interval.


A pelvic-brachial tonic postural reflex mediated through the cervical afferents.


The electroencephalogram in anorexia nervosa.


Differential epileptogenic action of penicillin on cortical and subcortical brain structures.


Click evoked micro-reflex and cortical potentials in the cat.


Evoked visual, somatosensory, myogenic, oculogenic and electroretinographic potentials of photosensitive epileptic patients and normal control subjects.


Visual evoked response to plain and patterned light in amblyopia ex-anopsia.


Some differences in the EEG of brain tumors and cerebral vascular accidents.


Further studies of i.v. diazepam (Valium) and evoked potentials of photosensitive epileptic subjects and normal controls.


EEG and behavioral findings in temporal lobe epileptics (before and after temporal lobectomy).


EEG findings in chronic rheumatoid arthritics receiving gold therapy.


The EEG in congenital heart disease.

The EEG in congenital heart disease.


The high incidence of mental disturbances in the family of schizophrenic children with excess of immature slow waves in the EEG.


Polygraphic studies in newborn infants.

Polygraphic studies in newborn infants.


The significance of some unusual EEG findings.


Startle disease (pathological surprise reaction).


The value of the EEG in the differential diagnosis between ischaemia and space-occupying lesions.


History of development of clinical electroencephalography in the Netherlands.


Some correlations between the results of echoencephalography and electroencephalography.


Echo pulsations in arterio-venous aneurysms.


The EEG in 17 cases of lesions of the brain stem, established post mortem.