Whole body skeletal scintiphotography in the detection of occult metastatic breast carcinomas. Whole body skeletal scintiphotography was carried out in a series of 111 breast cancer patients. The results of scintiphotography were compared with the results of roentgenography and with the diagnostic usefulness of serum alkaline phosphatase levels and the presence or absence of bone pain. In 27 percent of cases, lesions were first identified with the scintiphotos. When lesions were present on both scintiphotos and roentgenograms, involvement generally appeared greater on the scintiphotos. Two false negative studies were recorded. Sixty-seven percent of patients with early metastasis-that is, those with positive scintiphotos and negative roentgenograms-were asymptomatic. Serum alkaline phosphatase levels were normal in 38 percent of those with early skeletal involvement. Skeletal scintiphotography is superior to other commonly employed techniques used to assess bone metastasis in breast carcinoma.


Atypical diabetic coma.

Atypical diabetic coma.


IgG-1(kappa) M component after bone marrow transplantation.


Biosynthesis of the fifth component of complement (C5) by human fetal tissues.


Antinuclear antibodies and nuclear antigens in rheumatoid synovial fluids.


Generation of chemotactic factors in guinea pig serum via activation of the classical and alternate complement pathways.


Thirty-two fatal cases of severe diabetic ketoacidosis, including a case of mucormycosis.


Experimental allergic uveitis. Studies on characterization and isolation of the pathogenic retina antigen.


Serological studies of Haemophilus influenzae. IV. The antibody response in rabbits against capsular and O antigens of H. influenzae.


Leucocyte migration inhibition to Mycoplasma fermentans in patients with rheumatoid arthritis.


Tubular lesions produced by autoantibodies to tubular basement membrane in human renal allografts.


The effect of hypoxia on radiation life-shortening in Drosophila melanogaster.


Inhibition of allergic reactions by cromoglycate and by AH 7079 in patients with allergic airway disease.


The location of antibacterial activity in the rat prostatic secretions.


Inhibition of bacterial urease.

Inhibition of bacterial urease.


Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF.


Alpha chain of glycoprotein hormones: presence in human serum after thyroid stimulating hormone releasing hormone.


Ultrastructure of giant pigment granules (macromelanosomes) in the cutaneous pigmented macules of neurofibromatosis.


Oxidation of furans. 2. Synthesis and biological properties of 6-hydroxy-2H-pyran-3(6H)-ones and derivatives.


In vivo metabolite condensations. Formation of N1-ethyl-2-methyl-N3-(2,6-dimethylphenyl)-4-imidazolidinone from the reaction of a metabolite of alcohol with a metabolite of lidocaine.


Synthesis of the thyrotropin-releasing hormone enantiomer and some diastereoisomers and in vitro studies of their biological activity.


Tubeless hypotónic duodenography.

Tubeless hypotónic duodenography.


Synthesis of antimicrobial nitroimidazolyl 2-sulfides, -sulfoxides, and -sulfones.


Protective role of prednisolone upon galactosamine-induced hepatitis in rats.


Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.


Cordycepin and alpha-amanitin: inhibitors of transcription as probes of aldosterone action.


Prevention and mitigation of head injury from antiquity to the present.


The mechanism of injury in blunt abdominal trauma.


Defective hemoglobin function: a complication of hyperalimentation.


Lung transplantation: a review of its current studies.


Response to thyrotropin-releasing hormone compared with thyroid suppression tests in euthyroid Graves' disease.


Evolution of 5S RNA and the non-randomness of base replacement.


Studies on the division cycle of mammalian cells. VII. X-ray sensitivity and repair capacity of synchronously dividing murine mastocytoma cells.


Alpha-fetoprotein in Rh-immunized pregnancies.


X-ray-induced alterations in marker replication pattern in Bacillus subtilis W23.


Sudanophilic lipids in the unmyelinated primate cerebral white matter after intrauterine hypoxia and acidosis.


The role of ontogeny in the establishment of species-specific patterns.


Laser flash photolysis studies of chlorin and porphyrin systems. I. Energetics of the triplet state of bacteriochlorophyll.


Proceedings: Treatment of perennial childhood asthma.


Effects of measles on the immune response of Nigerian children.


Proceedings: Control of infection in children with leukaemia and lymphomas.


Treatment of chronic urinary tract infection in children. I. Propicillin-dicloxacillin combination for Pseudomonas aeruginosa infections.


Letter: Monkeys for research.

Letter: Monkeys for research.


Fetal cell counting as a guide to prevention of Rh sensitization.


Phosphorylase and glycogen synthetase during myoblast differentiation.


Structural studies on the specific capsular polysaccharide from Rhizobium trifolii, TA-1.


The preparation and biological activity of novel amino acid analogs of butirosin.


Granulomatous bacterial arthritis.

Granulomatous bacterial arthritis.


The open fracture. Cause, effect and management.


Delay in the onset of immune hemolysis in vivo apparently due to heparinization.


Antibiotics. An overview.

Antibiotics. An overview.


Comparison of gram-negative bacillary and staphylococcal osteomyelitis of the femur and tibia.


A comparison of the fluorometric and microbiological assays for estimating riboflavin content of blood and liver.


Australia antigen in professional blood donors and student volunteers at Poona.


Acute severe insulin resistance. A case report.


A theoretical EHT study of structure-activity relationships in a series of sulfonamides.


Eye diseases in two families of animals.


Undernutrition.

Undernutrition.


Nutrition and behavior and learning.

Nutrition and behavior and learning.


Nutrition and disease.

Nutrition and disease.


Two different patterns of segmentation in eggs of Bufo arenarum.


Degradation of progesterone by aspergilli-side chain cleaving enzymes.


Blood group mosaicism involving the rhesus and Duffy blood groups.


Radiation induced pericarditis in Hodgkin's disease.


Three examples of Rh-positive, good responders to blood group antigens.


Behaviour of intravenously injected 51CrCl3 in irradiated and nonirradiated mice.


Electron irradiation of monkey skin.

Electron irradiation of monkey skin.


Distribution of 226Ra in the bones of mice.


Gold in the dermis following gold therapy for rheumatoid arthritis.


Identification and clinical implications of isoantibodies in patients with idiopathic dysgammaglobulinemia.


Heparin sensitivity. Report of a case.

Heparin sensitivity. Report of a case.


Diagnosis of deep infection with Candida. A study of Candida precipitins.


Dispersal activities of the sibling species Drosophila melanogaster and Drosophila simulans.


The chemical composition and serological reactions of lipopolysaccharides from serogroups A,B,X, and Y Neisseria meningitidis.


Hepatitis B antigen: distribution of ad and ay subtypes in blood donors and hepatitis patients. Hepatitis B antigen (HBAg) from blood donors and patients with hepatitis was tested for ad and ay subspecificity by immunodiffusion in agarose. A total of 59 sera from blood donors and 81 sera from hepatitis patients were subtyped.Subtyping of HBAg from blood donors showed ad and ay subspecificity in 64.4 and 35.6% of cases respectively. Patients' sera on the other hand showed HBAg with ad and ay subspecificity in 6 and 94% of cases respectively. Therefore, ad subtype was more frequently associated with blood donors whereas ay subtype was predominant among hepatitis patients. The relationship between clinical findings and HBAg subtype is also discussed.


Editorial: In pursuit of Pneumocystis carinii.


The extensor assembly of Saimiri sciurea.


A logic to long-term care.

A logic to long-term care.


Community care for the elderly: an alternative to institutionalization.


Genetical study of Angami Nagas (Nagaland, India): A1A2BO, MN, Rh blood groups, ABO(H) secretion, PTC taste sensitivity and colour-blindness.


Further studies on genetically mediated differences in monooxygenase activities and spin state of cytochrome P450 iron from rabbit, rat, and mouse liver.


Further genetic and enzymological characterization of the three Bacillus subtilis deoxyribonucleic acid polymerases.


Calorimetric studies of thymidylate synthesis.


Polymorphism of Rhesus monkey serum prealbumin. Purification and partial structure.


The effects of modification of the COOH-terminal regions of bovine thyrotropin and its subunits.


The effects on rabbits of immunization with bovine thyroid-stimulating hormone and its subunits. Rabbits were immunized with bovine thyroid-stimulating hormone (bTSH), bovine Inteinizing hormone (bLH), and their subunits. In two immunization experiments, thyroid-stimulating activity was found in the serum of 6 out of 12 rabbits immunized with bTSHbeta subunits. The thyroid-stimulating activity in the anti-bTSHbeta sera was greater at 2 h than at 8, was eluted with the globulin fraction from Sephadex G-100, was completely neutralized by both anti-bTSH and anti-rabbit gamma globulin, and was completely suppressed by administration of triiodothyronine (T(3)) to the immunized rabbit. These findings led to the conclusion that the thyroid-stimulating activity resided in soluble complexes of rabbit TSH bound to anti-bTSHbeta. Two of nine rabbits immunized with bTSH developed thyroid-stimulating activity in their serum, but it was nonsuppressible by T(3). None of the animals immunized with bTSHalpha, bLH, bLHbeta, or bLHalpha developed serum thyroid-stimulating activity.Hypopituitary hypothyroidism, evidenced by decreased serum thyroxine (T(4)) and thyroidal (131)I uptake and by the histologic appearance of large follicles with flat cells, was found in the bTSHbeta- and bTSH-immunized animals, despite the presence of thyroid-stimulating activity in the serum of many. The reasons for this paradox are unclear; possibly the complexes block the effect of TSH on the rabbit thyroid.


B lymphocytes in untreated patients with malignant lymphoma and Hodgkin's disease. B and T lymphocytes in 37 untreated patients with malignant lymphoma and Hodgkin's disease were studied. B cells in the peripheral blood were investigated with respect to surface immunoglobulins and in a few patients with respect to intracytoplasmic immunoglobulins by means of immunofluorescence. T cell function was studied by direct phytohemagglutinin (PHA) microtest (from the same sample of whole blood), mixed lymphocyte culture (MLC), and by delayed hypersensitivity to various antigens. In the 13 patients with Hodgkin's disease the histologic subtype was nodular sclerosis in nine, lymphocyte predominant in two, mixed cellularity in two. Only one of these patients had disseminated disease (stage IV); he showed impaired cellular immunity, a very low percentage of B cells and low levels of serum immunoglobulins. Of the remaining patients with Hodgkin's disease, with one exception, normal percentages but rather low absolute numbers of B lymphocytes per mm(3) of blood were found. One patient with a low percent and low absolute number of B lymphocytes showed very high serum IgG. Of 24 patients with non-Hodgkin's malignant lymphoma, seven (29%) showed monoclonal B cell proliferation in the peripheral blood (five mukappa, two gammakappa). By morphologic criteria, 14 patients had involvement of bone marrow, five of these had involvement of peripheral blood. Four of the latter five patients showed marked increases in percentages and absolute numbers of B lymphocytes in the peripheral blood reflecting the monoclonal proliferation. In three additional patients monoclonal proliferation of lymphocytes was found by immunofluorescence although the blood smears appeared morphologically normal. Serum immunoglobulin abnormalities without monoclonal B cell proliferation in the peripheral blood were observed in six patients.


Characterization of ileal vitamin B12 Binding using homogeneous human and hog intrinsic factors. Elucidation of the mechanism of intrinsic factor (IF)-mediated vitamin B(12) (B(12)) binding to ileal binding sites has been hampered by the use of crude or only partially purified preparations of IF in previous studies. We have used homogeneous human IF and hog IF isolated by affinity chromatography to study [(57)Co]B(12) binding to ileal mucosal homogenates. The following observations were made: (a) Human IF-B(12) and hog IF-B(12) were bound to human, monkey, hog, dog, rabbit, mouse, hamster, and guinea pig ileal, but not jejunal, homogenates in amounts significantly greater than free B(12) or B(12) bound to five other homogeneous B(12)-binding proteins; (b) only IF-mediated B(12) binding was localized to ileal homogenates and was inhibited by EDTA; (c) values for the association constant (K(a)) for the various ileal homogenates mentioned above and human IF-B(12) and hog IF-B(12) ranged from 0.3 x 10(9) M(-1) to 13.0 x 10(9) M(-1). Apparent differences in the K(a) for human IF-B(12) and hog IF-B(12) existed in most species; (d) the number of ileal IF-B(12) binding sites per gram (wet weight) of ileal mucosa ranged from 0.3 x 10(12) to 4.9 x 10(12). The same value was always obtained with human IF-B(12) and hog IF-B(12) for any given homogenate preparation; (c) 100-fold excesses of free B(12) or human IF and hog IF devoid of B(12) did not significantly inhibit human IF-B(12) and hog IF-B(12) binding to human and hog ileal homogenates. THESE EXPERIMENTS PERFORMED WITH HOMOGENEOUS IF INDICATE THAT: (a) gastric factors other than IF are not required for B(12) binding to ileal IF-B(12)-binding sites: (b) the mechanism of ileal IF-B(12) binding is different from that of free B(12) or of B(12) bound to non-IF-B(12)-binding proteins; (c) human IF and hog IF have different structures; (d) human IF-B(12) and hog IF-B(12) bind to the same ileal binding sites; and (c) human and hog ileal IF-B(12) binding sites bind free B(12) and human and hog IF devoid of B(12) poorly, if at all.


Medical education and medical care. Problems at the interface. Urban problems: Social Security and the teaching hospital.


Medical education and medical care in Puerto Rico.


Detection of fibrinogen antigens with two latex techniques applied to urine concentrates. Fibrinogen antigens were measured either with an agglutination inhibition method (using latex particles coated with fibrinogen; Diagen test) or with a direct agglutination technique (using latex particles coated with a mixture of anti-D and anti-E antibodies; Thrombo-Wellcotest). Both methods were compared with the tanned red cell haemagglutination inhibition immunoassay (TRCHII) during progressive degradation of fibrinogen with plasmin and using purified fibrinogen fragments or urine concentrates from chronic glomerulonephritis or transplanted patients. Due to the different sensitivity of the two latex techniques to fibrinogen and its plasmin derivatives, their combined use may be helpful to distinguish the nature of the fibrinogen-like material excreted in urine.


The localization of calcium in skeletal muscle: its distribution in muscles in which the caffeine-induced contracture was arrested.


Relapsing form of subacute necrotizing encephalomyelopathy.


Direct evidence for a colchicine-induced impairment in the mobility of membrane components. Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.


Intestinal resorption of gold salts used for treatment of rheumatoid arthritis.


Determination of carbonic anhydrase (E.C. 4.2.1.1.) activity by means of the pH-stat-technique.


Immunological investigations into the causes of aspecific ABR-reactions.


Human meningoencephalitis caused by the free-living amoebae.


Mouth care.

Mouth care.


Under the cover of his charm.

Under the cover of his charm.


A nurse for all reasons.

A nurse for all reasons.


Aegyptopithecus endocasts: oldest record of a pongid brain.


Semi-natural and enclosed groups of Macaca mulatta: a behavioral comparison.


Small analytical BD-cellulose columns for rapid chromatography of aminoacyl-tRNAs.


A rapid electrophoretic procedure for the detection of SDS-released oncorna-viral RNA using polyacrylamide-agarose gels.


Isozyme variability in species of the genus Drosophila. VII. Genotype-environment relationships in populations of D. melanogaster from the Eastern United States.


Glucose 6-phosphate dehydrogenase from brook, lake, and splake trout: an isozymic and immunological study.


Regulation of phenylalanine biosynthesis in Pseudomonas aeruginosa.


Comparative analysis of malate dehydrogenases of Drosophila melanogaster.


The sialic acids of toad oviduct mucoprotein.


The production and purification of specific anti-soybean agglutinin antibody by affinity chromatography.


Metabolism of sialic acids in toad oviduct.


Phosphotransacetylase from Bacillus subtilis: purification and physiological studies.


Study of correlation between structural motility and reactivity of SH groups in alpha-amylase.


Pig kidney particulate aminopeptidase. A zinc metalloenzyme.


Acetolactate synthase of Pseudomonas aeruginosa I. Purification and allosteric properties.


Acetolactate synthase of Pseudomonas aeruginosa. II. Evidence for the presence of two nonidentical subunits.


Haloperidol in the treatment of nausea and vomiting due to cytotoxic drug administration.


Anxiolytic effects of a new triazolobenzodiazepine, U-31,889.


Nitroglycerin: clinical pharmacological effects of form and route of administration.


Clindamycin palmitate hydrochloride: a clinical trial in a pediatric office practice.


Treatment of acute hypercalcemia with furosemide.


Double-blind study of acetylcysteine-isoproterenol and saline-isoproterenol in non-hospitalized patients with asthma.


Influence of intravenous administration of hypertonic solution on pain sensibility.


Comparison of various precipitin tests in the detection of alpha-fetoprotein in serum.


Macrophage-mediated resistance to intracellular infection induced by poly-L-glutamic acid.


The stoichiometry of J chain in human secretory IgA.


Recombination of the polypeptide chains of a Waldenström's IgM that binds IgG.


Quantitative phagocytosis by neutrophils. I. A new method with immune complexes.


Migration inhibition of rat peritoneal cells induced by streptococcal mucopeptides. Characteristics of the reaction and properties of the mucopeptide preparations.


Quantitative phagocytosis by neutrophils. II. Release of the C5-cleaving enzyme and inhibition of phagocytosis by rheumatoid factor.


Human antibody to dengue soluble complement-fixing (SCF) antigens.


Isolation of mucin from human submaxillary secretions.


Inversion injuries of the ankle.

Inversion injuries of the ankle.


Rosette formation by guinea pig thymocytes and thymus derived lymphocytes with rabbit red blood cells.


Diverticula of the appendix.

Diverticula of the appendix.


Renal failure associated with the use of thio-tepa.


The role of computers in the nuclear medicine laboratories.


Cholesterol gallstones.

Cholesterol gallstones.


Whole-body counting.

Whole-body counting.


Acute diverticulitis.

Acute diverticulitis.


Safety tests of orgotein, an antiinflammatory protein.


Effect of osmotic concentration and pH on sclerotia and cleistothecia production in alkaline and fertile soil Aspergilli.


An attempt to classify the toxic proteins of Elapidae and Hydrophiidae venoms.


On the natural history of coccidial infections in feeder cattle.


Influence of fixation on physiological properties of frog gastric mucosa.


Metabolism of 14C-histamine in goats and pigs treated with aminoguanidine.


On the elimination of transfused heparin-induced diamine oxidase (DAO) activity in rabbits.


Effect of organ removal or damage on the heparin-induced diamine oxidase (DAO) response in rat and rabbit.


Application of gas chromatography, mass spectrometry, and computer methods in clinical biochemistry.


The outcome of stroke at hospital discharge in New York City blacks.


Studies on the methylation of mercuric chloride by pure cultures of bacteria and fungi.


Monomolecular films of bacteriochlorophyll and derivatives at an air-water interface: surface and spectral properties.


Australia antigen and circulating antibodies in chronic aggressive hepatitis.


Mucolipidosis 3 (pseudo-Hurler polydystrophy): cytological and ultrastructural observations of cultured fibroblast cells.


Relief of musculoskeletal and associated psychopathological symptoms with meprobamate and aspirin: a controlled study.


Controlled evaluation of a new topical corticosteroid in psoriasis.


Diazepam (calmpose) in eclampsia: a preliminary report of 16 cases.


A double-blind comparison of active and inert douches in vaginitis.


Safety and effectiveness of haloperidol for mentally retarded behaviorally disordered and hyperkinetic patients.


The effect of lithium and other antidepressant medications on the autonomic nervous system.


Serum levels of anhydrous ampicillin administered orally in normal infants.


Disposition of arabinosylcytosine (NSC-63878) and 6-THIOGUANINE (NSC-752) in solid L1210 leukemia tumor-bearing mice.


Studies of Anatrichosoma (Nematoda: Trichinellida) with descriptions of Anatrichosoma rhina sp. n. and Anatrichosoma nacepobi sp. n. from the nasal mucosa of Macaca mulatta.


An improved method for the scanning electron microscopy of spermatozoa.


Advances in radiotherapy--improved results following treatment with high energy electrons and 25 MEV X-ray. 1.


Metabolic profile of a new immunosuppressive agent, oxisuran: binding, RE stimulation, drug interaction.


Diffusive and electrostatic effects with insolubilized enzymes subject to substrate inhibition.


Near-cytotoxic gold salt therapy in long standing drug-refractory rheumatoid arthritis. A prospective investigation.


A qualitative demonstration of the degradation of folic acid by Pseudomonas fluorescens UK-1.


Antigenic relationship between lysozymes and its use in isolation and purification of this type of enzyme.


Cartilaginous transformation of the aortic valve.


Beta-fetoprotein as a thymus-dependent factor in humans.


Fibrin degradation products in the postoperative period. Evaluation of a new latex agglutination method.


Development of nonspecific factors of antiinfection resistance of monkeys in ontogenesis.


Endocarditis caused by Bacillus subtilis.


Studies on the variables in Rh slide testing.


Miliary tuberculosis.

Miliary tuberculosis.


Studies on the bacteriophage of a natural lysogenic Mycobacterium fortuitum.


Clinical significance of casual isolation of acid-fast organisms from sputum of tuberculous patients.


Letter: Correlation of lymphocyte transformation with tuberculin skin-test sensitivity.


Tropical problems in nutrition.

Tropical problems in nutrition.


Pseudomonas aeruginosa resistant to carbenicillin and gentamicin. Epidemiologic and clinical aspects in a cancer center.


Urate secretion in man: the pyrazinamide suppression test.


Neisseria gonorrhoeae auxotyping: differentiation of clinical isolates based on growth responses on chemically defined media. A system is described for differentiating clinïcal isolates of Neisseria gonorrhoeae based on their growth or absence of growth on a set of 11 chemically defined agar media. The complete medium, NEDA, contains all of the compounds required for gonococcal growth; but isolates differ in their ability to grow on NEDA from which selected compounds are individually omitted. The differential compounds include L-proline, L-arginine, L-ornithine, L-methionine, hypoxanthine, uracil, thiamine, and thiamine pyrophosphate. A distinctive pattern of growth responses on the standard media defines an auxotype. Twenty auxotypes were found among a group of 251 gonococci which were isolated from patients examined in the clinics of one city during a 3-month span of time. Another collection of 74 strains from several different countries yielded two additional auxotypes. The stability of the nutritional requirements on which the auxotyping depends was verified in two ways. Cultures isolated from different anatomic sites of a patient or from sexual partners represented the same auxotype, as did cultures which were repeatedly isolated from cases of presumptive treatment failures. Also, the auxotypes of gonococci remained the same after numerous subcultures. The reproducibility of results and the variety and number of auxotypes indicate the potential value of the auxotyping system as an epidemiological tool.


Detection and identification of diagnostic Histoplasma capsulatum precipitates by counterelectrophoresis. Studies were carried out to develop and evaluate a counterelectrophoresis (CEP) technique for the rapid and specific identification of the diagnostically important histoplasmosis H and M precipitin bands. Well-defined and centrally located precipitin bands were produced by using a discontinuous buffer system and a gel matrix composed of agarose and ionagar no. 2. A template was devised which allowed the selective identification of the H and M precipitins. Comparative evaluations were performed with the microimmunodiffusion (ID) and complement fixation tests. In 52 sera from persons with histoplasmosis, either the H or M precipitin, or both, were identified in 42 (81%) of the cases with the CEP technique and in 43 (83%) with the ID test. With sera from 28 persons with heterologous diseases, the CEP technique, like the ID test, failed to react. The specificity of the CEP technique was dependent upon the use of the identity template. The CEP technique is recommended for routine use in laboratories testing moderate numbers of sera. It provides accurate and reproducible results within 90 min, in contrast to the ID test, which requires 18 to 24 h.


Specific immunodiffusion test for blastomycosis. A specific immunodiffusion test for blastomycosis has been developed. The test permitted the detection of approximately 80% of 113 proven cases of blastomycosis. Two diagnostically important precipitins designated A and B were frequently recognized in patients with blastomycosis. Routine use of reference sera containing the A and B precipitins in immunodiffusion tests would permit the specific diagnosis of blastomycosis without the need for parallel tests with coccidioidin and histoplasmin.


Variation in colonial morphology of Neisseria gonorrhoeae after growth on media containing antimicrobial agents. Stable colonial types 1, 2, 3, and 4 were prepared from eight strains of Neisseria gonorrhoeae. Four of the strains, termed laboratory strains, had been transferred over 100 times; three strains, termed clinical strains, were transferred only three to five times after isolation from patients, and one stabilized clinical strain was transferred purposefully 30 times after isolation from a patient. Colonial types of the three categories were grown on four media containing the following agents at the level used in diagnostic media: (i) vancomycin, colistin, and nystatin; (ii) these antibiotics plus trimethoprim lactate; (iii) trimethoprim lactate alone; and (iv) a control with no antimicrobial agents. When grown on media containing the antimicrobial agents, colonial types 1, 2, and 3 of all strains showed specific and consistent changes that precluded accurate identification of the types. In general, the colonies were smaller, more dense to transmission of light, and more granular than colonies grown on control medium. More colonies showed these type changes in the clinical strains and on media containing trimethoprim lactate. Colonies of type 4 showed little or no change. The changes in colonial morphology of types 1, 2, and 3 were pronounced enough to make colony typing difficult if the antimicrobial agents, particularly trimethoprim lactate, were present in media.


In vitro studies with Modoc virus in Vero cells: plaque assay and kinetics of growth, neutralization, and thermal inactivation. A sensitive and quantitative assay system is described for plaquing Modoc virus in Vero cells. Neutralizing antibodies to Modoc virus could be detected by using this in vitro system by their interference with viral plaque formation. Virus was readily neutralized within 30 min at 37 C by a 1:10 dilution of hyperimmune hamster serum. The rate of neutralization and the total amount of virus neutralized was not altered significantly by the addition of 20 U of guinea pig complement to the hyperimmune hamster serum. A study of the growth of Modoc virus in Vero cells is also presented. After an initial latent period of 20 h, viral titer increased exponentially for 20 h. By 83 h after infection, 8,000 plaque-forming units of virus were detected per cell. The stability of viral infectivity in phosphate-buffered saline at pH 7.4 was evaluated. No reduction in viral titer was detected after 3 days at 7 or 22 C. A continuous decrease in infectivity at 37 C was observed, however, throughout the observation period.


Microtissue culture plaque assay for Herpesvirus saimiri. A microtissue culture method for the plaque assay of Herpesvirus saimiri has been developed. Virus titrations carried out in Microtest II tissue culture plates (Falcon) yielded reproducible results that agreed well with those obtained by employing macrocultures. The described method is quantitative, reproducible, economical, and suitable for routine assay of large numbers of virus samples.


Sensitivity of three selected bacterial species to ozone. THE MINIMAL LETHAL CONCENTRATION OF OZONE IN WATER WAS DETERMINED FOR THREE BACTERIAL SPECIES: Escherichia coli, Bacillus cereus, and Bacillus megaterium. A contact period of 5 min was selected. The lethal threshold concentration for the cells of B. cereus was 0.12 mg/liter while that for E. coli and B. megaterium was 0.19 mg/liter. Low concentrations of ozone were ineffective when organic matter was present to interfere with the action of ozone on the bacterial cells. Also determined during the study was the sensitivity of spores of B. cereus and B. megaterium to ozone in water. The threshold concentration required to kill the spores of both species was 2.29 mg/liter. The cells and spores of these organisms exhibited the "all-or-none" die-away phenomenon normally associated with ozone treatment.


Modification of the starch block electrophoresis method for the preparation of immunoglobulin A from multiple myeloma sera on a large scale. Separation of immunoglobulin A from a large sample of human serum from patients with multiple myeloma was done by utilizing a large zone electrophoresis apparatus.


Clinical evaluation of sodium amylosulfate in human blood cultures. Sodium amylosulfate was shown to be a useful anticoagulant additive for increased isolation of bacteria from clinical blood cultures.


Temperature adaptability of psychrotrophic Pseudomonas. The rate of oxidation of glucose and alanine at low temperatures by washed cells of psychrotrophic strains of Pseudomonas is related to growth temperature.


Comparison of atmospheric conditions for culture of clinical specimens of Neisseria gonorrhoeae. We cultured 55 clinical specimens of Neisseria gonorrhoeae in the following atmospheric conditions: (i) 10% carbon dioxide in a CO(2) incubator; (ii) a candle extinction jar; (iii) an air convection incubator; and (iv) an anaerobic jar without added CO(2). The number and size of colonies growing on modified Thayer-Martin medium were evaluated after incubation of cultures for 24 and 48 h at 36 C. After 24 h, the specimens from the candle extinction jar had the greatest number and size of colonies, but after 48 h growth was approximately equal for specimens from the candle jar and the CO(2) incubator. Only 19 of 55 specimens grew in the air convention incubator. None of 55 clinical specimens or of 10 laboratory strains grew anaerobically. Development of colonial morphology for colony types 1, 2, 3, and 4 was studied at 24 h on a base medium that contained no hemoglobin. The relative numbers of the four colony types in specimens were comparable after 24 h of incubation in any of the three atmospheric conditions under which growth occurred, but the different types were distinguished most readily when grown in the candle extinction jar.


Lytic activity of vibrio phages on strains of Vibrio fetus isolated from man and animals. Five phages isolated from lysogenic strains of Vibrio fetus var. venerealis and two from V. fetus var. intestinalis were tested for lytic activity on 95 V. fetus strains from various animal and human hosts. In addition, virion and plaque morphology of the seven phages were compared. Electron micrographs showed that all were the kite-tailed variety with minor variations in head and tail dimensions. Plaques of V45 and V2 were small, clear and irregular; those of V3, V8, and V19 were large, clear and regular at the edge; the plaques of V16 and V20 were intermediate in size, clear, and very irregular at the edge with satellite plaques. The number of strains lysed by one or more phages were as follows: 29 of 30 from cattle; 7 of 11 from sheep; 1 of 5 from pigs; 1 of 1 from a monkey; and 33 of 42 from human hosts. Four natural groups of phages were derived by statistical measures of percentage of similarity in lytic activity. Group III lysed more strains (46 of 95) than any of the others. Twenty-five strains were lysed by group IV, 23 strains by group I, and 19 strains by group II. Results of this study indicate that phage typing should be a practical supplement to other differential tests for V. fetus.


Effect of glutaraldehyde on cell viability, triphenyltetrazolium reduction, oxygen uptake, and beta-galactosidase activity in Escherichia coli. Acid (pH 5) and alkaline (pH 8.5) glutaraldehyde solutions were compared for their effects on cell viability, oxygen uptake, and beta-galactosidase activities in Escherichia coli. The action of glutaraldehyde at pH 7 on dehydrogenase activity was also studied. Dehydrogenase activity was inhibited at aldehyde concentrations which had little effect on cell viability. In contrast, oxygen uptake and beta-galactosidase activity took place in cells killed by acid or alkaline glutaraldehyde. The effect of glutaraldehyde on dehydrogenase activity and beta-galactosidase activity of disrupted suspensions was also investigated. The dialdehyde was considerably less inhibitory to these enzyme systems than to those of whole cells, and it is thus feasible that the results with whole cells are a consequence of its interaction with, and strengthening of, the outer cell surface, thereby preventing ready access of substrate to enzyme.


Microtiter solid-phase radioimmunoassay for hepatitis B antigen. A micro-solid-phase radioimmunoassay (micro-SPRIA) for hepatitis B antigen (HB Ag) was developed for use with microtiter serological equipment. Radiolabeled immunoglobulin G was prepared from human and animal sera containing hepatitis B antibody (HB Ab); it was not necessary to isolate specific HB Ab by immunochemical means. A micro-SPRIA prepared with guinea pig reagents was approximately as sensitive as the AusRIA radioimmunoassay, but, like the AusRIA test, yielded false positive results. A micro-SPRIA prepared with human reagents was slightly less sensitive but did not yield false positive results. These micro-SPRIA tests offer several advantages, including conservation of reagents, adaptability to other antigen-antibody systems, ease of performance (especially when testing large numbers of specimens), and economy.


Peroxidase diffusion in the normal sensory retina.


Treatment of central nervous system leukemia with intrathecal cytosine arabinoside.


Controlled prospective trial of Pseudomonas aeruginosa vaccine in children with acute leukemia.


Yolk sac tumor (endodermal sinus tumor) and alpha-fetoprotein. A report of three cases.


Congenital diverticulum of the left ventricle associated with hypoplastic right ventricle and ventricular septal defect.


The effect of clinical pharmacy services on patients with essential hypertension.


Editorial: Nitrates in the prophylactic treatment of angina pectoris.


Influence of albumin on the hepatic uptake of unconjugated bilirubin.


Suppression of plasma renin by atherogenic levels of serum cholesterol in rabbits.


Relationship between plasma cortisol and peak expiratory flow rat in exercise-induced asthma and the effect of sodium cromoglycate.


Induction of glycoprotein mating factors in diploid yeast of Hansenula wingei by vanadium salts or chelating agents.


Non-histone proteins. The effect of nuclear washes and comparison of metaphase and interphase chromatin.


Binding of a tritiated thyrotropin-releasing factor to a prolactin secreting clonal cell line (GH3).


Transition-state analogs of an aliphatic amidase.


Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus.


Inhibition of leucocyte migration by tumour-associated antigens of the colon and rectum. The test of leucocyte migration inhibition has been used to detect lymphocyte sensitization to tumour-associated antigens of the colon and rectum. The procedure for the isolation of antigens from colorectal adenocarcinomata and normal colonic mucosa is described. The circulating lymphocytes of 22 patients suffering from colorectal adenocarcinomata of various stages have been examined and compared with the results obtained for identical studies performed on the peripheral lymphocytes of 15 control subjects. Sensitization of lymphocytes to tumour antigen was demonstrated in 15 of the 22 patients when culture was performed in homologous AB serum. Of these 15 patients only six showed inhibition of leucocyte migration in the presence of tumour extract when culture was performed in autologous serum. These observations would suggest the presence of factors in the serum of such patients which may prevent the expression of cellular immunity to tumour antigens.


Gluconeogenesis from amino acids in mature wether sheep.


Studies of the protein requirement of the neonatal rat.


Differential effects of protein-calorie restriction and subsequent repletion on neuronal and nonneuronal components of cerebral cortex in newborn rats.


Letter: Selenium and dental caries susceptibility.


Conformation of sodium cromolyn in aqueous solution using light scattering and magnetic birefringence.


Partial purification of antigen E from mixed stems and leaves of short ragweed plant.


Assay of thiotepa by PMR spectrometry.

Assay of thiotepa by PMR spectrometry.


Concentration of penicillin V and tetracycline in maxillary sinus secretion after repeated doses.


Shift in viral strains of hepatitis B in Stockholm as reflected by subtypes of hepatitis B antigen.


Hepatitis-associated antigen, subtypes D and Y. An epidemiological and clinical evaluation.


Experimental alcoholic hepatitis: a new primate model. Research into the pathogenesis of alcoholic cirrhosis has suffered from the lack of an animal model of alcoholic hepatitis, considered by many to be the link between alcoholic fatty liver and cirrhosis. The entire constellation of histologic features characteristic of alcoholic hepatitis has been produced for the first time in baboons by administration of ethanol with a nutritionally adequate diet. This includes fat, necrosis. inflammation, alcoholic hyaline, fibrosis, and central hyaline sclerosis.


Phosphate-induced protein chromatography. High phosphate concentration is shown to cause a large proportion of the proteins of a cell-free extract of Escherichia coli to bind to agarose columns to which L-valine is attached. With a decreasing concentration gradient of potassium phosphate, the proteins elute in relation to their solubility in concentrated ammonium sulfate. This column technique appears to provide a general tool for the purification of proteins.


Unstable angina.

Unstable angina.


The pattern of epilepsy in Uganda.

The pattern of epilepsy in Uganda.


Pathogenic leptospira isolated from toad kidneys.


Comparative aspects of morphogenesis in three prokaryotic genera.


Readiness for synthesis of red and brown pigments in the imaginal eye disks of Drosophila melanogaster.


Nitrogen fixation by photosynthetic microorganisms.


Biology of Trypanosoma cruzi.

Biology of Trypanosoma cruzi.


Characterization of circadian oscillations in alanine dehydrogenase activity in non-dividing populations of Euglena gracilis (Z).


Studies on the biochemical basis of oxygen toxicity.


Antigenic variants of influenza B virus. From 1967 to 1971 little antigenic variation was detected in the prevalent influenza B viruses but in December 1972 a new antigenic variant of influenza B was isolated in Hong Kong from sporadic cases of influenza. The new variant, B/Hong Kong/5/72, possessed a haemagglutinin antigen which showed considerable antigenic differences from that of former influenza B strains while its neuraminidase antigen was closely related to that of the earlier, 1967-71, isolates. The B/Hong Kong/5/72 variant became the predominant influenza B strain in the United Kingdom by early summer 1973, and in both the United Kingdom and Japan this strain was associated with outbreaks of influenza. Strains antigenically intermediate between the 1967-71 isolates and B/Hong Kong/5/72 were isolated in a number of countries, often concurrently with B/Hong Kong/5/72-like strains.Serological studies indicated that antibody to B/Hong Kong/5/72 was infrequent in the populations in the United Kingdom and the U.S.A., suggesting the possibility of future epidemic activity associated with the new variant. In addition, conventional inactivated influenza vaccines containing the older influenza B isolates given to volunteers stimulated poor antibody responses to B/Hong Kong/5/72 virus. These studies indicate the desirability of immunizing high risk patients against B/Hong Kong/5/72-like viruses before the coming influenza season. Vaccine containing the new variant influenza B strain are currently available in the United Kingdom.


Specificity of cell wall labeling with triated diaminopimelic acid in Bacillus subtilis.


Psychotrophic gram-positive bacteria: temperature effects on growth and solute uptake.


Antigenic comparison between in vivo and in vitro grown tubercle bacilli.


Control of tartrate utilization in Aspergillus flavus.


The phyloantigenic position of nocardiae revealed by examination of cytoplasmic antigens.


Favorable effects in vitro and in vivo of two clinical isolates of Pseudomonas aeruginosa on nutritionally deficient Staphylococcus aureus strains.


Distribution along X-chromosome of recessive lethals induced by direct and indirect X-radiation effect in Drosophila.


Supplementary parenteral nutrition in patients with malignant disease. Guidelines to patient selection.


Australia (hepatitis-associated) antigen in urban endemic hepatitis at Poona.


Effect of phenobarbital and DL-ethionine on 4-(dimethylamino)azobenzene-metabolizing enzymes and carcinogenesis.


Analysis of the schedule of DNA replication in heat-synchronized Tetrahymena. The temporal schedule of DNA replication in heat-synchronized Tetrahymena was studied by autoradiographic and cytofluorometric methods. It was shown that some cells, which were synchronized by selection of individual dividing cells or by temporary thymidine starvation, incorporated [(3)H]thymidine into macronuclei in a periodic fashion during the heat-shock treatment. It was concluded that supernumerary S periods occurred while cell division was blocked by high temperature. The proportion of cells which initiated supernumerary S periods was found to be dependent on the duration of the heat-shock treatment and on the cell cycle stage when the first heat shock was applied. Cytofluorometric measurements of Feulgen-stained macronuclei during the heat-shock treatment indicated that the DNA complement of these cells was substantially increased and probably duplicated during the course of each S period. Estimates of DNA content also suggested that the rate of DNA synthesis progressively declined during long heat-shock treatments. These results indicate that the mechanism which brings about heat-induced division synchrony is not an interruption of the process of DNA replication. Further experiments were concerned with the regulation of DNA synthesis during the first synchronized division cycle. It was shown that participation in DNA synthesis at this time increased as more cells were able to conclude the terminal S period during the preceding heat-shock treatment. It is suggested that a discrete period of time is necessary after the completion of DNA synthesis before another round of DNA synthesis can be initiated.


The relationship of concanavalin A binding to lectin-initiated cell agglutination. We have investigated the relationship of concanavalin. A binding to the cell surface of normal and transformed cells and the subsequent agglutination of the transformed cells. At room temperature almost no differences could be detected in agglutinin binding between transformed and untransformed cells. At 0 degrees C, however, where endocytosis was negligible, the transformed cells bound three times more agglutinin. However, transformed cells and trypsin-treated normal cells do not agglutinate at 0 degrees C although the amounts of agglutinin bound at 0 degrees C are sufficient to permit agglutination when such cells are shifted up to room temperature. Both transformed and trypsin-treated normal cells show a marked increase in agglutination at 15 degrees C as compared to agglutination at 0 degrees C. From this, as well as the observation that mild glutaraldehyde fixation of the cell surface inhibited agglutination but not agglutinin binding, it was concluded that concanavalin A-mediated cell agglutination requires free movement of the agglutinin receptor sites within the plane of the cell surface.


Localization of polysome-bound albumin and serine dehydratase in rat liver cell fractions. The polysomes involved in albumin and serine dehydratase synthesis were identified and localized by the binding to rat liver polysomes of anti-rat serum albumin and anti-serine dehydratase [(125)I]Fab dimer and monomer. Techniques were developed for the isolation of undegraded free and membrane-bound polysomes and for the preparation of [(125)I]Fab monomers and dimers from the IgG obtained from the antisera to the two proteins, rat serum albumin and serine dehydratase. The distribution of anti-rat serum albumin [(125)I]Fab dimer in the polysome profile is in accordance with the size of polysomes that are expected to be synthesizing albumin. By direct precipitation, it has been demonstrated that nascent chains isolated from the membrane-bound polysomes by puromycin were precipitated by anti-rat serum albumin-IgG at a level of 5-6 times those released from free polysomes. Anti-rat serum albumin-[(125)I]Fab dimer reacted with membrane-bound polysomes almost exclusively compared to the binding of nonimmune, control [(125)I]Fab dimer; a significant degree of binding of anti-rat serum albumin-[(125)I]Fab to free polysomes was also obtained. The [(125)I]Fab dimer made from normal control rabbit serum does not react with polysomes from liver at all and this preparation will not interact with polysomes extracted from tissues that do not synthesize rat serum albumin. Both anti-serine dehydratase-[(125)I]Fab monomer and dimer react with free and bound polysomes from livers of animals fed a chow diet or those fed a high 90% protein diet and given glucagon. In the latter instance, however, it is clear that the majority of the binding occurs to the bound polysomes. Furthermore, the specificity of this reaction may be further shown by the use of kidney polysomes that do not normally synthesize serine dehydratase. When these latter polysomes are isolated, even after the addition of crude and purified serine dehydratase, no reaction with anti-serine dehydratase-Fab fragments could be demonstrated. These results indicate that the reaction of the Fab fragments are specific for polysomes that synthesize rat serum albumin or rat liver serine dehydratase. Furthermore, they demonstrate that even with this high degree of specificity, some polysomes in the fraction labeled "free" are in the process of synthesizing rat serum albumin while bound polysomes to a significant, if not major, degree are the site of the synthesis of rat liver serine dehydratase.


Effect of aldosterone on active and passive conductance and ENA in the toad bladder.


Nitrobenzene reduction and reductive cleavage of azobenzenes in two species of Arachnida.


An electron cytochemical study of 6-phosphogluconate dehydrogenase activity in infected erythrocytes during malaria.


Enzymatic oxidation of linolenic acid in aqueous wheat flour suspensions.


Analysis of lipoxygenase nonvolatile reaction products of linoleic acid in aqueous cereal suspensions by urea extraction and gas chromatography.


Symposium on the patient with long-term illness. Foreword.


Social isolation and the nursing process.


Juvenile diabetes mellitus.

Juvenile diabetes mellitus.


Long-term care of the patient with cancer.


Human sexuality and nursing practice.

Human sexuality and nursing practice.


Pulpal responses to "composite" dental materials lined with Tubulitec or Dropsin.


A histopathologic study of replanted teeth with superficially demineralized root surfaces in Java monkeys.


Jejunal disaccharidases in children with selective IgA deficiency.


The immunoglobulin concentrations in serum and bowel secretion in patients with Crohn's disease.


Prevention of Rh-immunization. Modified production of IgG anti-Rh for intravenous application by ion exchange chromatography (IEC).


Production of antibodies against hepatitis-associated antigen in donkeys.


Some aspects of leucocyte behaviour in haemodialysis.


Congenital hypoproconvertinemia (factor VII deficiency). A report of two cases belonging to two different kindreds.


Platelet defect in a case of Ehlers-Danlos syndrome.


Pyknocytosis in heat-stroke.

Pyknocytosis in heat-stroke.


Beta-adrenergic blockade in essential hypertension. Effects of propranolol on hemodynamic parameters and plasma renin activity.


Mixed sodium chloride aerosol and nitrogen dioxide in air: biological effects on monkeys and rats.


Lymphocytic beta-glucuronidase in the lymphoproliferative syndromes.


The availability of food folate in man.

The availability of food folate in man.


Some applications of quantitative whole-body scanning in haematology.


Carcinoma of the duodenum: comparison of surgery, radiotherapy, and chemotherapy.


Proceedings: the role of humoral factors and diamine oxidase activity in shock after intestinal ischaemia in rabbits.


Proceedings: factors determining marker concentration during continuous blood-volume measurement during haemorrhage and infusion.


Proceedings: implantation of pancreatic islets into the portal vein of diabetic rats.


Proceedings: the survival of transplanted isolated pancreatic islets in the omentum and testis.


Proceedings: human and computer-aided diagnosis of lower gastro-intestinal disorders in 468 patients.


The origin, course and termination of vestibulospinal fibers in the toad. An experimental-anatomical study, with comments on other descending supraspinal fiber systems to the spinal cord.


Effects of artificial mothers and visual experience on adrenal responsiveness of infant monkeys.


Testosterone-binding globulin in stump-tailed macaque monkeys (Macaca speciosa).


Acute and chronic oral toxicity of chlorinated dibenzofurans to salmonid fishes.


The search for chlorinated dibenzofurans and chlorinated dibenzodioxins in wildlife populations showing elevated levels of embryonic death.


Biological responses of the nonhuman primate, chicken, and rat to chlorinated dibenzo-p-dioxin ingestion.


Etiology of chick edema disease.

Etiology of chick edema disease.


Electron microscopic localization of occluding junctions in the primate ciliary process and pars plana.


Changes in corticosteroid usage by chronic asthma patients during a year of cromoglycate treatment.


Immersion refractometry of isolated bacterial cell walls. Immersion-refractometric and light-scattering measurements were adapted to determinations of average refractive indices and physical compactness of isolated bacterial cell walls. The structures were immersed in solutions containing various concentrations of polymer molecules that cannot penetrate into wall pores, and then an estimate was made of the polymer concentration or the refractive index of the polymer solution in which light scattering was reduced to zero. Because each wall preparation was heterogeneous, the refractive index of the medium for zero light scattering had to be estimated by extrapolation. Refractive indices for walls suspended in bovine serum albumin solutions ranged from 1.348 for walls of the rod form of Arthrobacter crystallopoietes to 1.382 for walls of the teichoic acid deficient, 52A5 strain of Staphylococcus aureus. These indices were used to calculate approximate values for solids content per milliliter, and the calculated values agreed closely with those estimated from a knowledge of dextran-impermeable volumes per gram, dry weight, of the walls. When large molecules such as dextrans or serum albumin were used for immersion refractometry, the refractive indices obtained were for entire walls, including both wall polymers and wall water. When smaller molecules that can penetrate wall pores to various extents were used with Micrococcus lysodeikticus walls, the average, apparent refractive index of the structures increased as the molecular size of probing molecules was decreased. It was possible to obtain an estimate of 1.45 to 1.46 for the refractive index of wall polymers, predominantly peptidoglycans in this case, by extrapolating the curve for refractive index versus molecular radius to a value of 0.2 nm, the approximate radius of a water molecule. This relatively low value for polymer refractive index was interpreted as evidence in favor of the amorphous, elastic model of peptidoglycan structure and against the crystalline, rigid model.


Role of methionine in biosynthesis of prodigiosin by Serratia marcescens. Methionine alone did not allow biosynthesis of prodigiosin (2-methyl-3-amyl-6-methoxyprodigiosene) in nonproliferating cells (NPC) of Serratia marcescens strain Nima. However, when methionine was added to NPC synthesizing prodigiosin in the presence of other amino acids, the lag period for synthesis of prodigiosin was shortened, an increased amount of the pigment was formed, and the optimal concentrations of the other amino acids were reduced. Less prodigiosin was synthesized when addition of methionine was delayed beyond 4 h. The specific activity of prodigiosin synthesized by addition of (14)CH(3)-methionine was 40 to 50 times greater than that synthesized from methionine-2-(14)C or (14)COOH-methionine. NPC of mutant OF of S. marcescens synthesized norprodigiosin (2-methyl-3-amyl-6-hydroxyprodigiosene), and the specific activity of this pigment synthesized in the presence of (14)CH(3)-methionine was only 5 to 13 times greater than that synthesized from methionine-2-(14)C or (14)COOH-methionine. A particulate, cell-free extract of mutant WF of S. marcescens methylated norprodigiosin to form prodigiosin. When the extract was added to NPC of mutant OF synthesizing norprodigiosin in the presence of (14)CH(3)-methionine, the prodigiosin formed had 80% greater specific activity than the norprodigiosin synthesized in the absence of the extract. The C6 hydroxyl group of norprodigiosin was methylated in the presence of the extract and methionine. Biosynthesis of prodigiosin by NPC of strain Nima also was augmented by addition of S-adenosylmethionine. Various analogues of methionine such as norleucine, norvaline, ethionine, and alpha-methylmethionine did not affect biosynthesis of prodigiosin by NPC either in the presence or absence of methionine.


Sites of cellular autolysis in Lactobacillus acidophilus. Ultrastructural changes which occur during cellular autolysis of Lactobacillus acidophilus strain 63AM Gasser in 0.05 M citrate buffer, pH 5.0, were examined. Early in the process, randomly distributed electron-dense patches were seen on the wall surface, along with an accompanying eversion of mesosomes. Later, after a loss of about 20% of the initial cellular turbidity, dissolution from the outside of nascent cross walls was seen. This observation was related to the normal process of cell separation. After this stage, short lengths of the cylindrical portion of the wall appeared to be completely removed in a random manner over the entire surface. This dissolution produced gaps in the wall which allowed the extrusion of membrane and cytoplasm. Although membrane was usually extruded through one major, polar, subpolar, or septal site, other secondary points of membrane extrusion were also frequently seen in the same cell section.


Isolation of the bacteriophage lambda receptor from Escherichia coli. A factor which inactivates the phage lambda can be extracted from Escherichia coli. This factor is a protein and is located in the outer membrane of the bacterial envelope. It is found in extracts of strains which are sensitive to phage lambda, but not in extracts of strains specifically resistant to this phage. We conclude that this factor is the lambda receptor, responsible for the specific adsorption of the phage lambda to E. coli cells. A partial purification of the lambda receptor is described. Inactivation of the phage by purified receptor is shown to be accompanied by the release of deoxyribonucleic acid from the phage.


New procedure for the isolation of membrane vesicles of Bacillus subtilis and an electron microscopy study of their ultrastructure. A rapid procedure for the isolation of membrane vesicles of Bacillus subtilis is described that minimizes the action of proteolytic enzymes, excreted by this organism, on the membrane proteins. The membrane vesicles obtained have, in addition to a low endogenous respiration rate, a low endogenous activity for transport of amino acids and carboxylic acids. In the presence of the electron donor, ascorbate-phenazine methosulfate, the transport activities for these compounds were comparable to the activities of intact cells. In addition, these activities were retained for a prolonged period of time. Electron microscopy examination of thin sections of the vesicles showed that the preparation consisted almost exclusively of membrane vesicles which were not contaminated with other cell components. The membrane vesicles, which are six to seven times smaller in diameter than protoplasts, often enclosed smaller vesicles. Freeze-etching of intact cells, protoplasts, and membrane vesicles showed that the orientation of the membrane of the vesicles was identical to the orientation of the plasma membrane in intact cells and protoplasts. This also held for the majority of the membranes of the enclosed vesicles, only 15% having the opposite orientation.


Kinetic studies of citrate synthase from rat kidney and rat brain.


Developmental block in citric acid cycle mutants of Bacillus subtilis. Mutants deficient in different enzymes of the citric acid cycle can be subdivided into two groups according to the frequency at which they produce heat-resistant spores in nutrient sporulation medium. However, the majority of cells can develop in this medium only to the axial filament stage I of sporulation; aconitase and isocitrate dehydrogenase mutants need the addition of glutamate to reach this stage.


Multiple genes for lysozyme in birds. Studies on black swan egg white lysozymes.


Structural organization of three pools of acetyl coenzyme A in Tetrahymena.


Effect of adenosine monophosphate on intermediate metabolism and ribonucleic acid synthesis in Tetrahymena.


Effect of tolbutamide on the intracellular flow of acetyl coenzyme A in Tetrahymena.


Studies on a nuclease from Ustilago maydis. I. Purification, properties, and implication in recombination of the enzyme.


Ionization behavior of the histidine residue in the catalytic triad of serine proteases. Mechanistic implications.


Serum heat stable alkaline phosphatase levels in normal and abnormal pregnancies.


Response of rats to amino acid supplementation of brown egg albumin.


Amino acid utilization during total parenteral nutrition in the surgical neonate.


The long-term total intravenous feeding of infants using peripheral veins.


Structural organization of the pars plana-ora serrata transition in the human and monkey eye with emphasis on protein barriers.


Circulating tissue antigens. II. Studies on an organ-specific antigen of human liver.


Solubilized myocardial adenylate cyclase: activation by prostaglandins.


Letter: Neurotoxic effects of glutamate.


Neurofibromatosis, renal artery aneurysms and hypertension: case report.


Letter: Stimulant drugs for problem children.


Anterior urethral valves.

Anterior urethral valves.


Determination of trace quantities of anticholinesterase pesticides.


Streptococcal epidemic in an aircraft carrier.


Carbonic anhydrase: a new method of detection on polyacrylamide gels using conductivity measurements.


Lipid-protein interactions of erythrocyte membranes: comparison of normal O, Rh (D) positive with the rare O, Rh null.


Mucopolysaccharidosis 3 A (Sanfilippo A disease): deficiency of a heparin sulfamidase in skin fibroblasts and leucocytes.


Study on the existence of TRH in the cerebrospinal fluid in humans.


Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats.


Comparison of techniques for quantifying serum alpha1-antitrypsin.


A tanned cell haemagglutination test for the detection of hepatitis-associated-antigen (Au-Ag) and antibody (anti-Au).


Voltammetric identification of organochlorine insecticides, polychlorinated biphenyls, polychlorinated naphthalenes and polychlorinated benzenes.


Experiments on Rouleu formation.

Experiments on Rouleu formation.


Dose-related effects of isoprenaline on the distribution of cardiac output and myocardial blood flow in conscious monkeys.


Experience with the use of computer simulation models in medical education.


The treatment of asthma.

The treatment of asthma.


Immunochemical analysis of tissue antigens in different corneal layers and sclera.


Effect of different complex nutrients on neomycin production by Streptomyces fradiae H.


Competition between inoculum strains of Rhizobium japonicum in the process of soybean nodulation during three planting periods.


Distribution of ABO and rhesus blood groups in patients with gastric carcinoma, with reference to its site of origin.


Tuberculous enteritis. A report of three patients.


Transmission of IgA to the rabbit foetus and the suckling rat.


Studies on the mode of action of glutaraldehyde on Escherichia coli.


Germination of spores of Bacillus cereus in milk and milk dialysates: effect of heat treatment.


Cross-reactive human blood group H-active polysaccharide from Helix pomatia. I. Detection with catfish anti-H and eel sera.


Border disease-like syndrome in lambs: antibodies to hog cholera and bovine viral diarrhea viruses.


A quantitative comparison of the faecal microflora of baboons fed a natural diet or a synthetic diet complete or deficient in pyridoxine or riboflavin.


Increased serum thyroxine levels in euthyroid narcotic addicts.


Abnormalities of hypothalamo-hypophyseal-thyroid axis in patients with Graves' ophthalmopathy.


A simple precipitin test for corticosteroid-binding globulin: use in a search for the absence of corticosteroid-binding globulin in 10,000 subjects.


Ferritin-tagged antibody cross-reactions among rinderpest, canine distemper, and measles viruses.


The production of interferon by chemostat cultures of mouse LS-cells grown in chemically-defined, protein-free medium.


Characterization of three phages lytic for Brucella species.


The growth of two togaviruses in cultured mosquito and vertebrate cells.


The length of the filamentous Pseudomonas aeruginosa bacteriophage Pf.


The significance of plasma proteins in urinary casts.


The effects of agents that modify muscarinic tone upon behavior controlled by an avoidance schedule that employs signaled unavoidable shock.


Standardized horse antihuman lymphocyte globulin for clinical use.


Mechanisms of motor control of two types of tracking movements in monkeys.


Electron microscope study of the endothelium of stored and cryopreserved monkey corneas.


Pseudomonas aeruginosa endocarditis. Report of a case, with review of the literature.


Esterase-2 in Ephestia kühniella. I. Genetics and characterization.


Diversity of RNA sequences in Drosophila melanogaster.


Search for nonallelic structural genes for gamma-chains of fetal hemoglobin in some primates.


On the relationship between the urea-soluble and citric acid-soluble proteins of bovine snout epidermis.


Some observations on future trends in nuclear diagnostic instrumentation.


The past seventy-five years in radiotherapy.


Pyruvate kinase from Hydrogenomonas H 16.


An enzyme from Bacillus subtilis B with exo-beta-N-acetylmuramidase activity.


Invertebrate animals--what can they contribute to cancer research?


Delayed cellular immunity response as measured by tuberculin testing of an elderly population.


Blood groups and hypertension.

Blood groups and hypertension.


Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion. The effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (O(2)a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischaemic and non-ischaemic areas of brain. As a result of focal cerebral ischaemia, 5-HT may accumulate in the brain and contribute to the progression of infarction.


Effect of carotid ligation on cerebral blood flow in baboons. I. Response to altered arterial PCO2. Measurements of cerebral blood flow (CBF) were made in anaesthetized baboons before and after ipsilateral carotid artery ligation and also after bilateral carotid ligation. Results showed that at normocapnia (PaCO(2) 38-39 mmHg) there was little change in cerebral blood flow on ipsilateral carotid ligation, but when both carotid arteries were tied the blood flow to the brain fell significantly. At hypercapnia (PaCO(2) 58-60 mmHg) the CBF/CO(2) gradient fell significantly on ipsilateral carotid ligation; on bilateral carotid ligation there was only minimal rise in cerebral blood flow in response to the rise in PaCO(2). At hypocapnia (PaCO(2) 20-21 mmHg) the gradients of fall in the CBF were similar before and after ipsilateral carotid ligation; after bilateral carotid ligation there was minimal change in the CBF in response to the fall in the PaCO(2). It is suggested that, although cerebral blood flow may be normal after ipsilateral carotid ligation, the circulatory reserve of the brain is not sufficient to meet physiological challenges. This may be the reason for the development of delayed neurological complications after carotid artery ligation.


Inactivation of transforming DNA by ultraviolet light. I. Near-UV action spectrum for marker inactivation.


Inactivation of transforming DNA by ultraviolet light. II. Protection by histidine against near-UV irradiation: action spectrum.


Inactivation of transforming DNA by ultraviolet light. 3. Further observations on the effects of 365 nm radiation.


Repair of ultraviolet-induced DNA damage in the subcellular systems of Bacillus subtilis.


Influence of disodium etidronate on clinical and laboratory manifestations of Paget's disease of bone (osteitis deformans).


Editorial: Diphosphonate treatment in bone disease.


Different effects of bursectomy of chickens on immune response to Newcastle disease virus and Salmonella pullorum antigens.


Toxicity resulting from feeding experimentally molded corn to broiler chicks.


The effect of external shell treatments on salmonella penetration of chicken eggs.


Epidemiology of Marek's disease (MD): studies on the incidence of MD precipitins in some zoo birds.


Respiratory rate and succinic dehydrogenase activity in the egg of Ciona intestinalis (ascidian) upon fertilization.


Bone formation and calcification in gastric cancer--case report and review of literature.


The parasexual cycle in Aspergillus flavus.


Monoamine oxidases: versatility of catalytic properties and possible biological functions.


Semisynthetic penicillins.

Semisynthetic penicillins.


Drug metabolism in canine duodenum.

Drug metabolism in canine duodenum.


Chemical structure and biochemical activity of cord factor analogs. 2. Relationships between activity and stereochemistry of the sugar moiety.


Interference of influenza-specific IgA antibodies present in throat washings with isolation of the virus.


Discontinuous ficoll gradient separation of normal and malignant cells: cytologic applicability. I.


Structure and configuration of the polyprenoid side chain of dihydromenaquinones from Myco- and Corynebacteria.


Roentgenographic evaluation in total hip replacement. A study of 100 McKee-Farrar prosthetic replacements.


Results of total hip replacement. A clinical follow-up study.


Clinical follow-up of total hip replacement.


A comparative review of the McKee-Farrar and Charnley total hip prostheses.


The statistics of the McKee-Farrar method of total hip replacement.


Three years of experience with total hip replacement.


Complications after total hip arthroplasty according to Charnley in a Swedish series of cases.


Some complications of total hip replacement.


A comparison of anubis baboons, hamadryas baboons and their hybrids at a species border in Ethiopia.


Adult male replacement in one-male troops of purple-faced langurs (Presbytis senex senex) and its effect on population structure.


Contribution to the ecology of Colobus polykomos satanas (Waterhouse, 1838) of Rio Muni, Republic of Equatorial Guinea.


Cyclic changes in cervical mucus and LH levels in the bonnet macaque (Macaca radiata).


Ovarian steroid patterns in peripheral plasma during the menstrual cycle in the rhesus monkey.


Persimmon bezoar in an epiphrenic esophageal diverticulum with endoscopic removal.


Threshold 60-Hz current required for ventricular fibrillation in subjects of various body weights.


Preparation HOE 105 (citenazone) in chemoprophylaxis of variola in monkeys: a preliminary communication.


Follow-up studies in oral lichen planus.


Screening of drugs for genetic effects.

Screening of drugs for genetic effects.


Morphologic changes in lymph node deposits of oral squamous carcinoma.


Healing of gingival mucoperiosteal flaps after marginal incision in apicoectomy procedures.


Mucoepidermoid carcinoma in a lymph node of the parotid sheath simulating condylar tumor.


An atypical mandibular tumor caused by Mycobacterium balnei.


Deoxyribonucleic acid repair replication in Pseudomonas aeruginosa after sublethal doses of silver sulfadiazine.


Malnutrition studies in Macaca mulatta. 3. Effect on cerebral lipids.


A simple method of estimating renal clearance by renography.


Lymphocyte transformation and serum agar gel diffusion of rabbits immunized against Neisseria gonorrhoeae and Neisseria catarrhalis.


Induction and reversion of the L-form of Neisseria gonorrhoeae.


Some enzymological properties of a hatching enzyme (chorionase) isolated from the fresh-water teleost, Oryzias latipes.


Immunochemical studies of adenosine deaminases from several vertebrates and a mollusc.


Isoelectric spectra of different classes of anti-erythrocyte antibodies.


Angina pectoris: diagnosis, evaluation and therapy.


Rapid quantitation of the immunopreciptin reaction in agarose gel by electroimmunodiffusion with paper discs.


A simple method for the simultaneous detection of human immunoglobulins of both light chain types.


The bithorax complex--a model for cell determination in Drosophila.


Accumulation of histidine, 3-methylhistidine, and homocarnosine in the brains of protein-calorie deficient monkeys.


Morphology and life history of Mitraspora cyprini Fujita, parasitic in the kidney of goldfish.


Pseudomonas aeruginosa infections in rats fed on monosodium glutamate with observations on the Pseudomonas flora in their intestines.


Penicillin resistance of gonococci in South Vietnam.


The diagnosis of farmer's lung.

The diagnosis of farmer's lung.


The effect of dextran-40 on capillary blood flow and capillary diffusion capacity in the anterior tibial muscle of subjects with intermittent claudication.


Paradox of the immune response to uncomplicated gonococcal urethritis.


A sensitive assay for the determination of dopamine in plasma.


The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas.


The growth of mixed population of Lactobacillus casei and nisin producing strain of Streptococcus lactis in batch and continuous cultures.


Behaviour of aflatoxins in some meat products.


Calcification and ossification in epulides in man (excluding giant cell epulides).


The latex agglutination test for the study of the M protein of group A streptococci and of the corresponding antibodies.


Hyperalimentation-a review.

Hyperalimentation-a review.


New jejunostomy feed.

New jejunostomy feed. Three patients with duodenal fistulae were fed solely with an easily prepared, inexpensive jejunostomy feed for 14, 21, and 23 days respectively. Sodium, potassium, and nitrogen balances became positive, diarrhoea did not develop, and body weight increased. The feed was life-saving: the patients' superficial veins were thrombosed, and percaval feeding was considered undesirable.


The modes of inhibitory effects of PCBs on oxidative phosphorylation of mitochondria.


Introductory remarks: new agents in psychiatry.


Chemistry of trazodone.

Chemistry of trazodone.


Pharmacology of trazodone.

Pharmacology of trazodone.


Clinical experience with a new psychotropic drug, trazodone: a review of literature.


Systematic clinical studies with trazodone: methodological aspects.


Trazodone in the treatment of organic brain syndromes, with special reference to psychogeriatrics.


Cerebral edema unresponsive to conventional therapy in neurosurgical patients with unsuspected nutritional failure.


Trazodone in the treatment of schizophrenias.


Trazodone in the treatment of affective disorders.


Trazodone and psychosomatic medicine.

Trazodone and psychosomatic medicine.


Trazodone in the treatment of psychoneuroses: a double-blind study.


A comparison of 4-hydroxybenzoic acid hydrazide (PAHBAH) with other reagents for the determination of glucose.


A correlation of radiographic, functional, and morphologic changes in baboon lung allografts. A comparison of two immunosuppressive regimens.


Transplantation of the lung. Correlation of physiologic, immunologic, and histologic findings.


Malaria debriefing: experience with 1552 returnees from Southeast Asia.


Clinical and serological responses to plague vaccine U.S.P.


Efficacy of surgery for intervertebral discopathy in military personnel.


The meaning of mottling on the colloidal radiogold liver scan.


Dermatophytes in military personnel.

Dermatophytes in military personnel.


Albert Calmette. The Saigon years 1891-1893: A historical review.


Causative factors resulting in the placement of dental restorations: A survey of 8891 restorations.


Use of psychotherapeutic drugs in the acute detoxification of heroin addicts.


Changes in red cell carbonic anhydrase B and serum iodothyronines in hyperthyroid subjects following 131-I treatment.


Editorial: The military as a leader in the struggle against atherosclerosis.


Proceedings: Cromolyn sodium. A panel discussion.


Mutations as possible replication errors in bacteria growing under conditions of thymine deficiency.


Effect of restricted use of phosphate-based detergents on Onondaga Lake. A marked decrease in the concentration of total inorganic phosphate in the epilimnion and hypolimnion of Onondaga Lake, New York State, has been observed during the 1(1/2) years between July 1971 and January 1973. This decrease has been correlated to the implementation of phosphate-limiting legislation. The response of characteristic plankton species has been investigated.


Diphtheria.

Diphtheria.


Biliary atresia: the current state of confusion.


Trypanosoma cruzi infections in Rhodnius prolixus refed on different hosts.


Bovine mycoplasmas: serological studies by double immunodiffusion, growth precipitation and growth inhibition.


Serum luteinizing hormone concentrations in male monkeys (Macaca fascicularis).


Proteases of Clostridium botulinum. IV. Inhibitors against proteases from Clostridium botulinum.


Fractionation of Listeria monocytogenes serotype 5.


Saturation in the competitive protein-binding assay of serum thyroxine.


Determination of serum glucose with o-toluidine without glacial acetic acid.


The presence of furan derivatives in patients receiving fructose-containing solutions intravenously.


Serum IgG, IgM and IgA concentration determined by the "linear plate" immunodiffusion technique in a normal population.


Ultrastructure of the 5S RNA locus in salivary gland chromosomes of drosophila melanogaster.


A study of lipoxidase in pea seeds and seedlings.


Selection for altered recombination frequency in Drosophila melanogaster.


Clinicopathologic conference: Acute illness with elevated serum amylase.


Nutritive value of processed Saccharomyces cerevisiae, Scenedesmus obliquus and Spirulina platensis as measured by protein synthesis in vitro in rat skeletal muscle.


Oxypertine and primate behaviour.

Oxypertine and primate behaviour.


The basic pharmacology of oxypertine.

The basic pharmacology of oxypertine.


Syntheses of the beta-D-glucosides of 4- and 5-hydroxy-1-naphthyl N-methylcarbamate.


Defective drug metabolism in rat liver in endotoxin shock.


Biosynthesis of mycolic acids. Formation of a C32 beta-keto ester from palmitic acid in a cell-free system of Corynebacterium diphtheriae.


Studies on the biosynthesis of glucolipid in Tetrahymena pyriformis.


Responses of trigeminal units in the monkey bulbar lateral reticular formation to noxious and non-noxious stimulation of the face: experimental and theoretical considerations.


Interhemispheric comparison of mirror image stimuli in chiasm-sectioned monkeys.


The relationship of subsurface cisternae and cisternal organs to symmetrical axon terminals in the primate sensorimotor cortex.


Sporogony of Leucocytozoon spp. in mammalophilic simuliids.


The management of chronic pain.

The management of chronic pain.


Correlations between pathological changes in the hind paws of rats with adjuvant arthritis and their response to anti-inflammatory and analgesic drugs.


Enteric infections in captive monkeys.

Enteric infections in captive monkeys.


Biochemical tests for cancer.

Biochemical tests for cancer.


Serological and prognostic significance of partial absorption anti-human globulin test for incomplete Rh antibodies.


Soft tissue sarcomas: an outline guide to management.


Unproven methods of cancer management. Gerson method of treatment for cancer.


Hepatitis associated antigen amongst blood donors in Delhi by counter-electrophoresis.


Carcinoma of the stomach.

Carcinoma of the stomach.


A follow-up study on diphtheria carriers among children below 5 years in a rural population of Lucknow District.


The scope of oral glibenclamide in the non-ketotic young diabetics.


Classics in oncology: Johannes Müller (1801-1858).


Some serological studies on Bacteroides corrodens.


Synthesis of lipoic acid by Streptococcus faecalis 10C1 and end-products produced anaerobically from low concentrations of glucose.


Newer methods for evaluating thyroid nodules.


Isolation and partial characterization of a temperature-sensitive mutant of Bacillus subtilis impaired in the development of competence for genetic transformation.


Intestinal fistulae.

Intestinal fistulae.


The healthy male carrier of the gonococcus.


Thought for food.

Thought for food.


Intravenous feeding of the newborn.

Intravenous feeding of the newborn.


IgA deficiency and autoimmune haemolytic anaemia.


Genetic dissection of behavior.

Genetic dissection of behavior.


Importance of dilantin blood levels in managing epilepsy.


Is there a protein problem?

Is there a protein problem?


The relation of starvation to hypoglycaemia and adrenocortical activity in newborn and six-week-old piglets.


Permeability of the mammary gland to large antibiotic molecules.


Observations on the synchronization of oestrus in Sarda sheep.


Changes in the cell pattern in vaginal smears of cattle during pregnancy.


Congenital heart abnormalities in the cat. A description of sixteen cases.


Electron-microscopic changes of the liver and kidneys in chickens treated with tannic acid.


An electron microscopical study of the cerebral cortex of the calf. 1. The normal calf.


The concept of population in biology. A logical analysis with a suggestion to diminish the confusion of thought.


Diisopropylfluorophosphate uptake by granulocytopoietic cells in chronic myeloid leukaemia and in normal individuals.


Ultrastructural features of phytohemagglutinin and concanavalin A-responsive lymphocytes in chronic lymphocytic leukemia.


Serum haemopexin concentration in patients with various haemoglobinopathies. Effect of splenectomy.


Splenic function and infection in sickle cell anemia.


Ribonucleic acid and phytohemagglutinin on rat leukocyte cultures within diffusion chambers.


Study of the effect of actinomycin D on the thrombocytopoiesis of mice, using 75Se-labelled methionine.


Experimental iris suture observed by electronmicroscope. A preliminary report.


Structure and function of nucleosides and nucleotides.


Recent results in insect pheromone chemistry.


Solid phase synthesis of peptides with carboxyl-terminal amides--thyrotropin-releasing factor (TRF).


Stereochemistry of the coenzyme-B12-dependent methylamalonyl-CoA-mutase reaction. Investigation with ethylmalonyl-CoA.


Nuclear medicine and radiochemistry.

Nuclear medicine and radiochemistry.


5'-Nitrates of pyrimidine nucleosides: nitric acid analogs of nucleotides.


Chemistry and significance of the carbohydrate moieties of human serum glycoproteins.


Methoxymethyl isocyanate as a new agent for reversible protection of SH groups in protein and peptide chemistry.


The Lutheran, Duffy and Kell blood groups.


Authropometric and genetic studies in a Russian Old Believer population.


Ag (x, y, a1, z, t) antigens in a Japanese population.


An immunological approach to the study of inherited differences in the activity of human erythrocyte phosphoglucose isomerase.


Absorption studies of iron and vitamin B12 by INMAS whole body counters.


Media for the isolation and preservation of N. gonorrhoeae.


Isolation of Kaisodi virus from ixodid ticks in he Kyasanur Forest disease area of Shimoga district, Mysore State, India.


Immunoglobulin specificity of Rh antibodies.


Localization of sucrase in the microvillous membrane of rabbit intestinal mucosal cells.


Limited proteolysis of human IgG by fruit bromelain.


Difference-spectrophotometry of the interaction of cycloheptaamylose with saccharifying alpha-amylase from Bacillus subtilis.


Neutral and amino sugar composition of thyroglobulin. Comparison of the compositions of different fractions of hog thyroglobulin and of thyroglobulins from various animal species.


Studies on mammalian glycosidases. V. Effects of metal ions upon acidic and neutral alpha-glucosidases, beta-galactosidases, and alpha-mannosidases in liver extract of rabbit.


Constant irrelevant cues and stimulus generalization in monkeys.


Effects of various coronary vasodilators on myocardial oxygen consumption.


Fine-structural changes of the synovial membrane in arthrosis deformans.


Glomerulonephritis associated with (infected) ventriculo-atrial shunt.


Notes on the use of stereological methods in comparative placentology.


Trace elements in human nutrition. Report of a WHO expert committee.


Ventricular tracking pacemaker and teletransmitter follow-up system.


Thyrotropin-releasing hormone as a pituitary-function indicator. A comparison with other tests.


Hypersensitivity pneumonitis in the monkey.


Amino acid transport in the cornea. I. 3-Aminoisobutyric acid uptake in the toad.


Encephalitozoonosis (nosematosis) of the cornea.


Use of horseradish peroxidase in identification of serum antibodies and immune complexes.


Metabolism and metabolic action of lead and other heavy metals.


Toxicity of beryllium and other elements in missile propellants.


Cyanophages-viruses attacking blue-green algae.


Cessation of deoxyribonucleic acid polymerase activity in amino acid-starved Tetrahymena pyriformis.


Immune response of guinea pigs to common enterobacterial antigen.


Touch epilepsy.

Touch epilepsy.


Chemistry and biology of the polyene macrolide antibiotics.


Immunologic homogeneity and electrophoretic heterogeneity of mouse melanoma tyrosinases.


Pulmonary arterial pressure and structure in the baboon Papio papio.


The sensitivity of the colloidal carbon technique in measuring pulmonary vascular permeability changes.


Cavitating pulmonary infarct: an unusual complication of parenteral alimentation.


Letter: Intragastric versus nasojejunal feeding of low-birth-weigh infants.


Mangement of intraurethral condyloma acuminatum.


Cellular and humoral immune response to group B streptococci.


Chemicals used topically for ringworm in Australia.


Letter: Prostaglandins, nutmeg and diarrhea.


Locomotor affinities of Hominoid tali from Kenya.


Gonorrhea amnionitis.

Gonorrhea amnionitis.


Amniotic fluid evaluation after intrauterine transfusion.


Optimal utilization of Rh immunoglobulin in induced abortion. A study which was designed to characterize and refine methods of identifying, educating, and treating Rh-negative women while monitoring Rh immunoglobulin use in an active abortion service is described.  A simple system for the rapid analysis of Rh immunoglobulin use was developed.  During a 7-week period, 255 of 265 Rh-negative unimmunized women received Rh immunoglobulin.  9 of the 10 women refusing it were older multiparas.  Previous surveys have shown the utilization rates ranging from 42% to 68%.  The 96.2% acceptance shown in this study is believed to demonstrate that optimal utilization can be approached with the appropriate procedures.  At PRETERM, an out-patient abortion service in Washington, D.C., where this study took place, all women requesting abortion are tested for Rh type by the routine slide method.  Serum from each specimen found to be Rh-negative is then tested for the presence of Rh antibody.  Results from Rh-negative women are hand carried from the laboratory to the medical area, where the lab results and a vial of Rh immunoglobulin are attached to the patient's chart.  The medical receptionist informs the counselor of the patient's blood type before the abortion.  The woman and her counselor discuss the implications of Rh-negative blood type and abortion and the use of Rh immunoglobulin.  An attempt is made to convince all women of the need for Rh immunoglobulin, regardless of their future child-bearing plans.  Immediately after the abortion, with the patient's consent, a nurse administers the Rh immunoglobulin.  All used and unused vials are returned to the laboratory.  An Rh-negative identification card is given to the patient.  There is no additional charge for Rh testing or Rh immunoglobulin.  The authors believe that with the increasing incidence of induced abortion, such procedures are vital if Rh immunization and Rh hemolytic disease of the newborn are to be prevented.


Studies on the phospholipase A2 in pyloric caeca of the starfish Asterina pectinifera.


Cell-free translation of influenza virus messenger RNA.


Ultrastructural basis of toxic hepatitis.


Adverse reactions to intravenous diazepam: a report from the Boston Collaborative Drug Surveillance Program.


Problems and progress in physiological psychology.


Proceedings: Cancer of the kidney--radiation therapy and its indications in non-Wilms' tumors.


Proceedings: Diagnosis and staging of prostatic carcinoma.


Proceedings: Radiation therapy in malignant testis tumors. I: Seminoma; II: Carcinoma.


Transfusion with wrong type of blood claimed too late.


Extended combination therapy of childhood rhabdomyosarcoma.


Prognostic signs and the management of the mycosis fungoides.


A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukemia patients.


The identification of two protease inhibitors in Drosophila melanogaster.


Binding of tryptophan to plasma proteins in several species.


Characterization of an unstable carbonic anhydrase (CAII) variant in the guinea pig (Cavia porcellus).


[Oxygen uptake and heat production of cynomolgus monkey (Macaca irus) in a primate restraining chair at ambient temperature of 25 degrees C and 10 degrees C (author's transl)].


Thymineless death in Lactobacillus acidophilus R-26. II. Factors determining the rate of the reproductive inactivation.


Productivity and heat generation of fermentation under oxygen limitation.


Increased resistance to malaria after Mycobacterium tuberculosis infection.


Regulation of biosynthesis of excessive metabolites. XIV. Incorporation of (U-14C) asparagine into the molecule of tetracycline.


The interaction of protein substrates (antigens) during an in vitro degradation by rabbit cathepsin D.


Personal health expenses among rural communities of North Arcot District.


Nutritional assessment of rural pre-school children.


The effect of trimethoprim on the activity of sulfonamides and antibiotics in experimental infections.


Distribution of trimethoprim-sulfamethoxazole in tissues of rhesus monkeys.


Antibacterial action of trimethoprim-sulfamethoxazole.


Various regimens of trimethoprim-sulfamethoxazole used in the treatment of gonorrhea.


Trimethoprim-sulfamethoxazole in the treatment of infections of the ears, nose, and throat.


Effects of trimethoprim and sulfisoxazole, alone and in combination, on growth and carriage of Neisseria meningitidis.


Trimethoprim-sulfamethoxazole in the treatment of typhoid and paratyphoid fevers.


Treatment of chronic carriers of Salmonella typhi and Salmonella paratyphi B with trimethoprim-sulfamethoxazole.


Phenylmorphan agonists-antagonists.

Phenylmorphan agonists-antagonists.


Synthesis and antibacterial activity of some substituted 4-quinolone-3-carboxylic acids.


Synthesis and antimalarial effects of 1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine and related substances.


The lambda head-tail joining reaction: purification, properties and structure of biologically active heads and tails.


Distribution of histone messenger RNA among free and membrane-associated polyribosomes of a mouse myeloma cell line.


Amino acid sequence of lysozyme from baboon milk.


Chemical modification of lincomycin: synthesis and bioactivity of selected 2,7-dialkylcarbonate esters.


Mesoionic purinone analogs. IV. Synthesis and in vitro antibacterial properties of mesoionic thiazolo(3,2-a)pyrimidin-5,7-diones and mesoionic 1,3,4-thiadizolo(3,2-a)pyrimidin-5,7-diones.


Electrokinetic studies of bacteria. 3. Effect of polyvalent metal ions on electrophoretic mobility and growth of Streptococcus faecalis.


Microbial food chains and food webs.

Microbial food chains and food webs.


Dual classification of tympanoplasty.

Dual classification of tympanoplasty.


Conserved terminal sequence in 18SrRNA may represent terminator anticodons.


DNA-binding proteins specific for cells infected by adenovirus.


Multiple heavy chains classes and light chain types on surfaces of cultured human lymphoid cells.


Successive visual discrimination performance in the monkey with brief stimuli.


Measurement of pituitary hormones: clinical applications. 4. Thyroid stimulating hormone.


Organochlorine pesticide residues and polychlorinated biphenyls in human milk, Colorado--1971-72.


Eggshell thinning, chlorinated hydrocarbons, and mercury in inland aquatic bird eggs, 1969 and 1970.


International cooperative study of organochlorine and mercury residues in wildlife, 1969-71.


Organochlorine pesticides and polychlorinated biphenyls in black duck eggs from the United States and Canada--1971.


Actinic keratoses in Bantu albinos. Clinical experiences with the topical use of 5-fluoro-uracil.


A one-year survey of a rural orthopaedic clinic in Zululand.


Dysentery and colienterocolitis. Some aspects of pathogenesis and pathological anatomy.


Age-induced changes of cerebral arteries in rats. An electron microscope study.


Dysplastic gliosis (spongioblastosis) and the Rosenthal fibres. Pathogenetic contributions.


Morphogenesis of plasmatic arterionecrosis as the cause of hypertensive intracerebral hemorrhage.


Upper gastrointestinal radiologic findings in hyperlipoproteinemic subjects.


Protein--energy deficiency in nonhuman primates: biochemical and morphological alterations.


Evidence for intestinal malabsorption of iodine in protein-calorie malnutrition.


Essential fatty acid deficiency in red cells after thermal injury: correction with intravenous fat therapy.


Protein-calorie malnutrition in Egypt. I. Immunoelectrophoretic studies on urinary proteins.


Pulmonary aspergillosis caused by Aspergillus fischeri var. spinosus: report of a case and value of serologic studies.


Monoclonal IgG-lysozyme (muramidase) complex in acute myelomonocytic leukemia: an unusual finding.


Multiple diverticula of the esophagus.

Multiple diverticula of the esophagus.


Intestinal neurofibromas in von Recklinghausen's disease.


Serum and amniotic fluid lactic dehydrogenase in pregnant women.


Chronic manganese intoxication.

Chronic manganese intoxication.


Editorial: Nourishment in illness.

Editorial: Nourishment in illness.


Some aspects of parenteral nutrition.

Some aspects of parenteral nutrition.


Quartan malarial infections in Aotus trivirgatus with special reference to renal pathology.


Candida albicans septicaemia during first half of pregnancy successfully treated with 5-fluorocytosine.


Editorial: Struggle with malaria.

Editorial: Struggle with malaria.


Combined test for assessment of anterior pituitary function. A combined test consisting of the simultaneous administration of insulin, thyrotrophin-releasing hormone (TRH), and luteinizing hormone and follicle stimulating hormone-releasing hormone (LH/FSH-RH) was performed in 24 people. Eleven of these also had the three individual tests performed separately, and the remaining 13 had a separate test of either LH/FSH-RH and TRH together or singly at a later date. In both normal people and patients, whether the tests were performed alone or in combination, no difference was found between the hormone responses (growth hormone, cortisol, LH, FSH, thyroid-stimulating hormone) seen to these stimuli.It is proposed that combined administration of insulin and the hypothalamic releasing hormones may be used as a single test for the assessment of anterior pituitary function. The test is convenient and time saving, and with care can be performed in outpatients.


Letter: Brachial plexus palsy after parenteral feeding.


New type of allergic asthma due to IgG "reaginic" antibody. This study was undertaken to examine the possibility that IgE is not the only immunoglobulin responsible for immediate allergic reactions. A group of asthmatics were investigated in whom immediate allergic reactivity of the bronchi to common inhalant allergens had been confirmed by provocation tests. Their sera were fractionated and the reaginic activity of the immunoglobulin classes was studied by passive cutaneous anaphylaxis testing in monkeys. The results showed that the immediate allergic reactions were due to IgE antibodies in most patients, but there was a group with reactions due to short-term anaphylactic IgG antibodies. It was not possible to inhibit the IgG-mediated responses with disodium cromoglycate. As these two groups had clearly different serum IgE levels the estimation of IgE provided an important guide to the management of these patients.


Letter: Thyrotrophin-releasing hormone, prolactin, and cholesterol.


Cefoxitin, a new semi-synthetic cephamycin: an in-vitro and in-vivo comparison with cephalothin. The activity of cefoxitin was compared with that of cephalothin against 229 bacterial strains. Cefoxitin was more active against most Gram-negative strains, notably against indole-producing Proteus spp., which are usually resistant to the cephalosporins. Cefoxitin was not susceptible to any significant extent to degradation by beta-lactamases produced by Gram-negative organisms. Against Gram-positive organisms, however, cefoxitin was considerably less active than cephalothin, but minimum inhibitory concentrations for Staphylococcus aureus were well within therapeutically attainable blood levels.Pharmacokinetic studies in 18 volunteers showed a higher and longer sustained antibiotic activity in serum and urine after injections of cefoxitin than after equal doses of cephalothin. Urinary recovery of cefoxitin activity was also much higher than that of cephalothin. No evidence of toxicity due to cefoxitin was found. Cefoxitin was slightly less painful after intramuscular injection than cephalothin.


Prostaglandin F2a and primate corpus luteum: a correlation of structure and function.