Depressive disorders: toward a unified hypothesis. Our scientific understanding of psychiatric syndromes, including the phenomena of depression, has been hampered because of: (i) the use of metapsychological concepts that are difficult to test; (ii) methodological and linguistic barriers that prevent communication among psychoanalysts, behaviorists, experimental psychologists, and psychiatrists; and (iii) the reluctance of psychiatrists to accept animal models as possible approximations of certain aspects of human psychopathology. We have attempted to demonstrate that the animal models simulate some of the central features of clinical depression (for example, helplessness and object loss), thereby allowing one to rigorously investigate them from developmental, behavioral, and biochemical perspectives. The object loss model, as a concrete version of a metapsychological-psychoanalytic concept, has enabled primatologists to study the disruption of an attachment bond. The behavioral model accommodates this concept to a broader generalization: loss of reinforcement or loss of control over reinforcement. We have reviewed the evidence that these processes involve the diencephalic centers of reward or reinforcement, thereby permitting integration of the psychoanalytical and behavioral formulations with the biochemical hypotheses. Also, we have presented data strongly suggesting that the breaking of an attachment bond in the primate represents significant loss of reinforcement that induces helplessness and disrupts motivated behavior. Finally, we have argued that the depressive syndrome could be caused by interactions of genetic, chemical, developmental, and interpersonal factors, all of which impinge on the diencephalic centers of reinforcement.


Experimental subacute spongiform virus encephalopathies in primates and other laboratory animals. The host range of subacute spongiform virus encephalopathies is described. The asymptomatic incubation period and the duration of the illnesses in various species of animal hosts is discussed along with information on additional species of Old World and New World monkeys and the domestic cat, which have been shown to be susceptible to subacute spongiform virus encephalopathies.


Instrumental conditioning of large-magnitude, daily, 12-hour blood pressure elevations in the baboon. Blood pressure and heart rate were monitored continuously in four baboons during extended exposure to a daily 12-hour conditioning procedure providing food and shock-avoidance as contingent consequences of prespecified increases in diastolic blood pressure. Sustained and significant increases (30 to 40 mm-Hg) in both systolic and diastolic blood pressure were maintained throughout the daily 12-hour conditioning sessions, accompanied by elevated heart rates.


Induction of an enzyme in genetically deficient rats after grafting of normal liver. Tissue from normal rat livers was grafted onto the livers of rats that were genetically deficient in bilirubin uridine diphosphate glucuronyltransferase activity. Twelve weeks after the grafting operation, the liver of the recipient rats had bilirubin uridine diphosphate glucuronyltransferase activity.


Controlled biliary drainage for large injuries of the liver.


Functional and morphologic changes after lung allografting in baboons.


Adult versus infant brain damage: behavioral and electrophysiological effects of striatectomy in adult and neonatal rabbits.


Structure and function of natural proteinase inhibitors.


Immunological study of carcinoembryonic antigen (CEA) and a related glycoprotein. A comparison has been made of the immunological properties of CEA (carcinoembryonic antigen) and another perchloric acid-soluble macromolecule which occurs in colonic and certain other carcinomata and which is here termed CEX. By using a variety of antisera it was shown that the two substances share common antigenic groups as well as having characteristic ones of their own. These latter groups have enabled the preparation of (a) antisera which give a gel diffusion line only with CEA and (b) and antiserum which gives a line only with CEX. No immunological difference could be found between CEX and the NGP of Mach or the NCA of von Kleist and Burtin. CEX was found in foetal gut, in plasma and associated with CEA in virtually all the tissues and fluids in which the latter occurs; the two appear to go hand-in-hand and no proof was found that CEX is either less or more cancer specific than CEA-it is merely found in greater quantity; neither substance showed absolute cancer specificity. The usefulness of a radioimmunoassay for CEX is discussed, and also the possibility of interference by CEX in the radioimmunoassay for CEA. Evidence of two molecular species of CEA has been found.


Significance of Pseudomonas aeruginosa in sputum. Pseudomonas aeruginosa was isolated from the sputum of 63 patients. In 34 the organism was a commensal, in 14 it was causing chronic suppuration, and in 10 had interfered with antibiotics directed against other organisms and was thus indirectly pathogenic. In five patients, all of whom died, the organism could have been acting as an acute pathogen. Attempts should be made to determine the nature of the organism's pathogenicity in a given patient and appropriate therapy withheld or administered accordingly.


Multiple precipitation of sera containing monoclonal IgG proteins in radial immunodiffusion.


Trial of chloramphenicol for meningitis in northern savanna of Africa. In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment.It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.


Visually evoked responses in the rat, guinea pig, cat, monkey, and man.


Delayed response deficits in squirrel monkeys with unilateral lesions in the midbrain reticular formation.


Hippocampal lesions produced by prolonged seizures in paralyzed artificially ventilated baboons.


Morphologic sex differences in primate brain areas involved in regulation of reproductive activity.


Activation of nisin production by UV-irradiation in a nisin-producing strain of Streptococcus lactis.


Regeneration of Drosophila melanogaster male leg disc fragments in sugar fed female hosts.


The biological effects of the bark of Saccoglottis gabonensis Urban (Humiriaceae) on microorganisms.


Conformational changes following interaction between retinol isomers and human retinol-binding protein and between the retinol-binding protein and prealbumin.


Interactions of all-trans, 9-, 11-, and 13-cis-retinal, all-trans-retinyl acetate, and retinoic acid with human retinol-binding protein and prealbumin.


Structure of a pentahexosylceramide (Forssman hapten) from canine intestine and kidney.


Combined action of beta-lactum antibiotics against gram-negative bacilli.


Experimental study of latency in typhus infection.


Immunological reactivity of chloramphenicol. I. Detection of antibodies, determination of levels and hypersensitivity.


Australia antigen: current concepts.

Australia antigen: current concepts.


The gonococcus--a tough bug to grow.

The gonococcus--a tough bug to grow.


Metabolic acidosis in infants infused with commercial amino acid mixtures.


Effects of maternal employment on the child. II.


The genetics of blue-green algae.

The genetics of blue-green algae.


Behavioral development after forelimb deafferentation on day of birth in monkeys with and without blinding. Four infant monkeys underwent somatosensory deafferentation of both forelimbs within hours after birth. Ambulation, climbing, and reaching toward objects developed spontaneously in each case. Thumb-forefinger prehension could be trained by operant shaping methods. Two infants deafferented at birth and blinded by eyelid closure were retarded in motor development by only 1 to 2 weeks. Results indicate that topographic sensory feedback and autogenetic spinal reflexes are not necessary after birth for the development of most types of movement performed by the forelimb musculature in monkeys.


Chlorhexidine as an inhibitor of pure bacterial and fungal cultures and dental plaque micro-organisms in sterilized saliva.


Comparative biology of prokaryotic resting cells.


Histochemical interpretation of fluorescein angiogram. II. Background fluorescence and macular dark spot.


Diazepam as therapy for convulsive seizures precipitated by chemical intoxicants.


Ecology of entomogenous viruses and fungi.


Experimental manipulation of desmosome structure.


Bacteria, spirochetes, and rickettsia as insecticides.


Increased aggregation of C-phycocyanin produced by phenol and benzene.


The characterization of the RNAs and aminoacyl-tRNA synthetases of the blue-green alga, Anacystis nidulans.


Fractionation of ribonucleic acid by centrifugation in mixed sodium-potassium iodide density gradients.


A new intratypic variant of coxsackie B6 virus.


Screening tests for argininosuccinic aciduria, orotic aciduria, and other inherited enzyme deficiencies using dried blood specimens.


Alkaline phosphatase of Drosophila melanogaster. I. Partial purification and characterization.


Esterase polymorphisms in Microtus ochrogaster: interaction and linkage.


Morphogenic effects of halogenated thymidine analogues on Drosophila. I. Quantitative analysis of lesions induced by 5-bromodeoxyuridine and 5-fluorouracil.


Induction of null-activity mutants for the acid phosphatase-1 gene in Drosophila melanogaster.


Levels of RNA and DNA in Drosophila melanogaster at different stages of development: a comparison between one bobbed and two phenotypically non-bobbed stocks.


Molecular pathology of ceruloplasmin.

Molecular pathology of ceruloplasmin.


Distribution of erythrocyte carbonic anhydrase B-type alleles in Japanese farm horses.


Conformational studies of nucleoprotein. Circular dichroism of deoxyribonucleic acid base pairs bound by polylysine.


Cross-linking of elongation factor EF-G to the 50S ribosomal subunit of Escherichia coli.


Mitochondria and chloroplasts as descendants of prokaryotes.


Neurofibrosarcoma of the orbit (malignant change in a plexiform neurofibromatosis).


Genome amplification and gene expression in the ciliate macronucleus.


Effect of cocaine on Na channel in toad skin.


Differential cytotoxicity of activated lymphocytes on allogeneic and xenogeneic target cells. II. Activation by phytohemagglutinin.


Survival and function of bursa-derived cells in bursectomized chickens.


Replicating DNA molecules from eggs of Drosophila melanogaster.


Immunological analysis of acidic proteins in the chromatin of Ehrlich ascites tumor cells.


Disappearance of multiple esophageal diverticula following treatment of esophagitis: serial endoscopic, manometric, and radiologic observations.


Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled (1-3H)cadaverine.


Automated photometric microbiological assay for monensin in poultry rations.


Infrared studies of DDT, structurally related halogenated pesticides, and some metabolites.


Collaborative study of a colorimetric determination of nitroglycerin in sublingual tablets.


Turbidimetric evaluation of bacterial culture resistance in disinfectant testing.


The death rate of lysogenic bacteria after ultraviolet induction follows Gompertz's law.


Recent evidence on tRNA and tRNA acylase-mediated cellular control mechanisms: a review.


Intrahepatic localisation of Australia antigen by fluorescent antibody technique.


Quantitative studies of Australia antigen in acute and chronic hepatitis. Evidence for an inverse relationship between circulating Au-antigen and transaminase values in patients with progression from acute to chronic hepatitis.


WHO Expert Committee on Biological Standardization: twenty-fifth report.


Ultrastructural studies of spermatogenesis in Drosophila melanogaster Meigen.


Ultrastructural study on contractile structures in mammalian nephron. Their development in the metanephros of human embryo.


Cholinesterase-containing nerve fibres on blood vessels in lungs of some laboratory mammals.


Regulation of tRNA.

Regulation of tRNA.


Factors affecting the zinc content of E. coli alkaline phosphatase.


Partial purification and properties of a nucleoside hydrolase from Crithidia.


Activation of glutaraldehyde-crosslinked chymotrypsinogen-A. Enzymatic activity and circular dichroism studies.


Purification and properties of enolase from swine kidney.


Triosephosphate isomerases and aldolases from light- and dark-grown Euglena gracilis.


Immunoglobulins of colostrum. I. Preparation and identification of ovine colostral immunoglobulins.


Immunization of animals with Australia antigen.


Possible linkage relationships between certain blood groups and schizophrenia or other psychoses.


Effects of genetic variation and culture conditions on the social behavior of Drosophila melanogaster.


Prostaglandin synthesis by the pregnant rat uterus at term and its possible relevance in parturition.


The distribution and induction of some drug-metabolizing enzymes in man.


Further experiments to establish that the analgesic action of aspirin-like drugs depends on the inhibition of prostaglandin biosynthesis.


Effects of indomethacin on rat gastric acid secretion and mucosal blood flow.


Platelet diphenoloxidases in progressive muscular dystrophy (P.M.D.).


Androgen-induced social dominance in infant female rhesus monkeys.


Care of the neurogenic bladder.

Care of the neurogenic bladder.


The general practitioner and the Oncology Organization.


Sarcocysts in the heart muscle of a foal.


Advances in methods of fertility regulation: report of a WHO scientific group.


Use of disodium cromoglycate during the course of specific desensitizing treatment in asthmatic patients.


Physiological gradients in development. A possible role for messenger ribonucleoprotein.


Reaction of bovine and ovine pituitary growth hormones with tetranitromethane.


Light-scattering effects on the circular dichroism of chloroplasts.


Relationships among enzymes of the beta-ketoadipate pathway. I. Properties of cis,cis-muconate-lactonizing enzyme and muconolactone isomerase from Pseudomonas putida.


Growth, isolation, and characterization of a yeast manganese alcohol dehydrogenase.


Relationships among enzymes of the beta-ketoadipate pathway. II. Properties of crystalline beta-carboxy-cis,cis-muconate-lactonizing enzyme from Pseudomonas putida.


Specialized paranodal and interparanodal glial-axonal junctions in the peripheral and central nervous system: a freeze-etching study.


Relationships among enzymes of the beta-ketoadipate pathway. 3. Properties of crystalline gamma-carboxymuconolactone decarboxylase from Pseudomonas putida.


Alterations of spatio-tactile discrimination after lesions of primate spinal cord.


Evidence for LH and FSH binding protein(s) in human and rat serum.


Effects of testosterone oenanthate on plasma concentrations of thyroxine, cortisol, testosterone and hormone binding proteins in patients with hypogonadism.


Reduced plasma thyrotropin response to thyrotropin releasing hormone after dexamethasone administration in normal subjects.


Glucose, FFA, IRI and GH response to I.V. glibenclamide.


Adverse reactions of antirheumatic drugs.


Differences in access into the central nervous system of ME7 scrapie agent from two strains of mice.


Scrapie in mice. Some effects on the brain lesion profile of ME7 agent due to genotype of donor, route of injection and genotype of recipient.


Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation.


Non-specific agglutination of Mycoplasma gallisepticum by rheumatoid factor-like antiglobulin in chickens infected with Streptococcus faecalis or Staphylococcus aureus.


Levels of IgM and IgG in the sera of normal and leukaemic calves.


Further evidence of plasma membrane material in skim milk.


Experimental brain death. I. Morphology and fine structure of the brain. The morphological characteristics of brain death were examined in baboons and cats after artificial cerebral ischaemia. All animals showed autolytic changes in the brain, ischaemic neuronal changes, midbrain haemorrhages, focal necrosis of the brain-stem, demarcation at C 1/C 2 cord segment, and displacement of cerebellar tissue. Ultrastructural examination revealed extreme brain oedema, autolytic changes, and complete obstruction of capillaries by astrocytic and endothelial swelling and intravascular blebs. These data indicate that brain death develops in several stages. If the process starts in the supratentorial space it first leads to a breakdown of the cerebral circulation and to transtentorial herniation. As a result, midbrain haemorrhages develop and the infratentorial pressure begins to rise. The second stage is terminated by demarcation of the brain. The circulatory arrest is initially caused by venous compression but becomes irreversible when vascular obstruction develops.


Blood parasites of Pekin Robins (Liothrix luteus).


Zschokkella floridanae sp. n. (Myxosporidea) from the goldspotted killifish, Floridichthys carpio (Günther).


Effects of glutaraldehyde and osmium tetroxide on hypotrichous ciliates, and determination of the most satisfactory fixation methods for electron microscopy.


Haematozoa in domestic chickens and guinea fowl in Tanzania and transmission of Leucocytozoon neavei and Leucocytozoon schoutedeni.


The polychlorinated biphenyls Aroclors 1248 and 1260: effect on and accumulation by Tetrahymena pyriformis.


Variation in glyoxylate bypass inducibility among strains of Tetrahymena pyriformis.


Hydroxyproline in Tetrahymena.

Hydroxyproline in Tetrahymena.


The prognosis following surgical removal of mastocytomas in dogs.


Biodegradation of oleates.

Biodegradation of oleates.


Thiazides and hypokalaemia in diabetic ketoacidosis.


Studies on Fes, a mutation affecting cystocyte cytokinesis, in Drosophilia melanogaster.


Relative safety of self inflicted overdose with relatively newer medications.


Aggregation of horseshoe crab (Limulus polyphemus) amebocytes and reversible inhibition of aggregation by EDTA.


Occlusion of the posterior ciliary arteries.


The effects of inhibition of protein synthesis on the phenotype of Abnormal-abdomen.


Multiple gene control of the tRNA aminoacylating system in Drosophila melanogaster.


A new sex factor of Pseudomonas aeruginosa.


Isolation of a transducing phage forming plaques on Pseudomonas maltophilia and Pseudomonas aeruginosa.


Possible human-animal paranormal events.


Benthic marine and blue-green algal species as a source of choline.


A neural system analysis of memory storage and retrieval.


The utilization of bacteria as food for Paramecium bursaria.


Intraluminal duodenal diverticulum in a child.


Plasma epinephrine and plasma norepinephrine concentrations in early diabetes.


The drosopterin pattern in various eye color mutants of the fruitfly. Drosophila melanogaster.


Maternal effects on x-ray-induced sex chromosome loss in mature sperm of Drosophila melanogaster: a storage effect in mature oocytes.


Simultaneous bilateral focal seizures without loss of consciousness.


Dominance measurements of low and high protein reared rhesus macaques.


Size heterogeneity of human IgA myeloma proteins. Relationships between polymers and "J" chain.


On the specificity of Pseudomonas aeruginosa alkaline proteinase with synthetic peptides.


Selective activation of T lymphocytes. Its possible application in the immunomanipulation of tumours.


East Coast fever: the infectivity for cattle of infective particles of Theileria parva harvested in various substrates.


Babesia argentina: intraerythrocytic location of babesial antigen extracted from parasite suspensions.


Characterization of a glycoprotein in the cyst fluid of Cysticercus tenuicollis from the goat.


Isolation of blood-stage merozoites from Plasmodium knowlesi malaria.


The responses to various stimuli of microfilariae of Dirofilaria corynodes, of Dipetalonema marmosetae and of unidentified species of filariae in Saimiri sciureus and Cacajao monkeys.


Measuring health care.

Measuring health care.


The establishment and maintenance of a small, inexpensive baboon colony for behavioral research.


Gastric pseudoadenomyosis in a Macaca mulatta.


Progesterone levels in the Sooty mangabey (Cercocebus atys) during the menstrual cycle, pregnancy and parturition.


Aortic intimal lesions and serum lipids in wild baboons.


Convenient sites for venipuncture in smaller primates.


Precursors of 5 S ribosomal RNA in Bacillus subtilis.


Whole-body retention of 65Zn after single and daily oral administration in young and adult mice.


Psychiatric and psychological research in the Navy before World War II.


An alternative method of flap reflection for mandibular third molars.


Acinic cell adenocarcinoma of minor salivary gland origin.


Optometry: ophthalmology's obligation.

Optometry: ophthalmology's obligation.


Serum triiodothyronine, total thyroxine, and thyroxine to triiodothyronine ratios in paired maternal-cord sera and at one week and one month of age.


Electromyography of the oral phase of deglutition in the Rhesus monkey (Macaca mulatta).


Effect of prostaglandins on oviduct motility in estrous rabbits.


Growth inhibition by L-phenylalanine in Agmenellum quadruplicatum. A clue to some amino acid interrelationships.


Metabolism and function of polyisoprenol sugar intermediates in membrane-associated reactions.


The effects of ethanol on the liver.

The effects of ethanol on the liver.


Immunochemical studies on cobrotoxin.

Immunochemical studies on cobrotoxin.


Production of anti-idiotypic and anti-class specific antibody using micro amounds of myeloma serum.


Corneal pathogenicity of Serratia marcescens in the rabbit.


Improved methods of non-oral neonatal feeding: a commentary.


Research on dengue in tissue culture. V. Production of anti-dengue antibodies in tissue cultures from monkeys inoculated with an attenuated type I dengue virus strain.


Pathogenesis and immunity of dengue infection in man.


Effect of synthetic thyrotropin-releasing factor (TRF) on pituitary TSH secretion in man, with special reference to the evaluation for TRF test.


If your patient can't tolerate the cold--suspect cryoglobulinemia.


Federal Medical Chiefs on progress and plans: Department of Defense.


Federal Medical Chiefs on progress and plans: Department of Health, Education, and Welfare.


Federal Medical Chiefs on progress and plans: Army Medical Department.


Federal Medical Chiefs on progress and plans: Navy Medical Department.


Federal Medical Chiefs on progress and plans: Air Force Medical Services.


Federal Medical Chiefs on progress and plans: Veterans Administration.


Preliminary report: comprehensive screening and education for sickle cell anemia.


Experience with mixed infections of Plasmodium falciparum and vivax.


Phencyclidine induced psychosis. The need to avoid unnecessary sensory influx.


Low-cost system of dispensing solutions to parallel-flow dialyzers.


Case for diagnosis.

Case for diagnosis.


Prolongation of active useful life.

Prolongation of active useful life.


Maternal dietary supplementation and infant birth weight.


Discrimination learning without reward.

Discrimination learning without reward.


WHO expert committee on drug dependence. Nineteenth report.


Chemotherapy of malaria and resistance to antimalarials. Report of a WHO scientific group.


Observations following high intensity white light exposure to the retina.


Abrasion of composite restorative material.


Limits for single cell protein utilization in human feeding.


An evaluation of nitrous oxide oxygen analgesia after two years of use.


Prescribing supplemental fluorine in fluoride deficient water suppliers.


Isozyme variability in species of the genus Drosophila. VI. Frequency-property-environment relationships of allelic alcohol dehydrogenases in D. melanogaster.


A novel hypoglycemic compound.

A novel hypoglycemic compound.


The basis for progress in chemotherapy.

The basis for progress in chemotherapy.


Cancer chemotherapeutic agents.

Cancer chemotherapeutic agents.


L-asparaginase for the treatment of cancer.


Chemotherapy of skin cancer.

Chemotherapy of skin cancer.


Chronic recurrent pancreatitis and pancreatic pseudocysts.


Effects of progesterone on the ocular hypertensive response to prostaglandin.


Detection of small amounts of pesticides in human biological material by thin-layer chromatography.


A chemotherapy-radiotherapy Rx regimen for children with stage 3 Hodgkin's disease.


A personal tribute to Sidney Farber, M.D. (1903-1973).


Protein A from Staphylococcus aureus. XVI. Alkylation with iodoacetic acid at different pH-values.


The purification of human polyclonal IgE by immunosorption.


Quantitative studies on the interaction of concanavalin A, the carbohydrate-binding protein of the jack bean, with model carbohydrate-protein conjugates.


J chain in pig immunoglobulins.

J chain in pig immunoglobulins.


Active sites of turtle and duck low molecular weight antibody to 2'4'dinitrophenol.


Early interactions between inhibitors and antibodies to lysozyme.


Equine anti-hapten antibody. VII. Anti-lactoside antibody induced by a bacterial vaccine.


Rabbit  -fetoprotein: immunochemical purification and partial characterization.


Immunochemical analysis of rat brain microsomes.


Detection of the e14 and e15 rabbit allotypic specificities by immunodiffusion in PEG agar.


Effect of cycloheximide on L-leucine transport by Penicillium chrysogenum: involvement of calcium. Cycloheximide (actidione) has an immediate inhibitory effect on amino acid transport by nitrogen-starved or carbon-starved mycelium suspended in phosphate buffer. High concentrations of phosphate alone are slightly inhibitory; cycloheximide appears to potentiate the effect of phosphate. Ca(2+) reverses the inhibition of transport caused by phosphate plus cycloheximide. Ca(2+) did not relieve the inhibition of protein synthesis. Cycloheximide promotes a continual uptake of (45)Ca(2+) by the mycelium. The cumulative results suggest that (i) membrane-bound Ca(2+) is involved in amino acid transport, (ii) cycloheximide labilizes the membrane-bound Ca(2+), and (iii) phosphate forms a complex with Ca(2+) making it unavailable for its role in transport. The effect of cycloheximide described above is observed within 1 to 2 min after addition of the antibiotic. This initial inhibition occurs more rapidly with 10(-3) M cycloheximide than with 10(-5) M cycloheximide. However, after a longer preincubation time, a curious inverse relationship between cycloheximide concentration and amino acid transport is observed. The mycelium incubated with 10(-5) M cycloheximide remains strongly inhibited (unless the antibiotic is washed away). The mycelium incubated with 10(-3) M cycloheximide recovers about 40% of the transport activity lost during the rapid initial phase. We have no obvious explanation for the inverse effect.


A mathematical model for the determination of viscoelastic behavior of brain in vivo. I. Oscillatory response.


The fracture characteristic of bone substance.


Movement and metabolism of phorate under field conditions after granular band applications.


Effects of physical and chemical agents on competing- and transforming-abilities of DNA in Bacillus subtilis.


Isolation of infectious bursal disease virus and distribution of precipitating antibodies in chicken sera.


Controlled evaluation of flurazepam hydrochloride, a new nonbarbiturate hypnotic.


The current status of HAA testing at Brooke Army Medical Center. A review of two years' experience.


Case for diagnosis.

Case for diagnosis.


Synchronized versus nonsynchronized electrocardioversion.


A study of communications between Walter Reed Army Medical Center and surrounding mental health units.


The relationship of mid-face fractures to mandibular fractures in various forms of trauma: study of 4,015 cases.


The treatment of closed head injury.

The treatment of closed head injury.


Volkmann's ischemia treated by transfibular fasciotomy.


Some challenges for military medicine in the next decade.


Vasopressin-resistant diabetes insipidus associated with short-term demethylchlortetracycline (declomycin) therapy.


Closed injuries of the ankle.

Closed injuries of the ankle.


Hormonal changes in pathological pregnancy.


Inhibitory effect of antibiotic Wr-142 on synthesis of nucleic acids and proteins in B. subtilis cells.


The effect of chloramphenicol on the production of cyanophycin granule polypeptide in the blue green alga Anabaena cylindrica.


Species and stage interaction in the feeding behaviour of vectors of Chagas disease (the importance of determinants in planning for greater efficacy and standardization of xenodiagnostic procedures).


Enzymatic characterization of a phenylalanine auxotroph of the blue-green bacterium Synechococcus cedrorum.


Human glomerular basement membrane. Selective solubilization with chaotropes and chemical and immunologic characterization of its components.


Characterization of monkey pox virus DNA genome.


Early events in cell-animal virus interactions.


Development and application of a rapid cell sorter.


Quantitation of serum lipids by a simple TLC-charring method.


The immunoassay of thyroid-stimulating hormone and its clinical applications.


Purification and molecular properties of an unspecific carboxylesterase (E1) from rat-liver microsomes.


Association-dissociation behaviour and hydrodynamic properties of apoferritin monomer and dimer.


Isolation of high-molecular-weight DNA from mammalian cells.


The synthesis and stability of ribosomal RNA in blue-green algae.


Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme.


Resorption of amyloid and enzymatic studies in amyloidosis.


Treatment of multirooted teeth with internal root resorption and perforation. Case history.


How to increase the utilization and efficiency of the office laboratory for fixed prosthesis.


Studies on the adaptation of the toad Bufo viridis to high salinities: oxygen consumption, plasma concentration and water content of the tissues.


Survival versus growth of a facultative psychrotroph meat and products of meat.


The oviducts of the Egyptian cow in health and disease.


A primordial bifunctional polyglucan-forming enzyme.


Purulent pneumococcal pericarditis. A continuing problem in the antibiotic era.


An assessment of the role of parenteral alimentation in the management of surgical patients.


Effects of saline and colloid resuscitation on renal function.


Serotonin and central nervous system function.


Congenital goiter in four euthyroid siblings with glandular and circulating iodoproteins and defective iodothyronine synthesis.


Gene loci for the skin and their chromosomal positions.


Antimicrobials. New nitrofuran derivatives.


Preparation and biological activity of various 3-deazapyrimidines and related nucleosides.


Gonorrhoea.

Gonorrhoea.


Biological basis for high-LET radiotherapy.


Aural tuberculosis in children.

Aural tuberculosis in children.


Absorption of edema following ankle fractures.


Influence of heparin-plasma, EDTA-plasma, and serum on the determination of insulin with three different radioimmunoassays.


Potential environmental chemical hazards. 3. Industrial and miscellaneous agents.


Serum immunoglobulin levels in five villages of the Republic of Chad and in onchocerciasis patients with and without microfilaruria.


Suppression of Plasmodium falciparum malaria in Aotus monkeys by milk diet.


Cell mediated immunity in mice innoculated with epimastigotes or trypomastigotes or Trypanosoma cruzi.


General mechanisms of regeneration as elucidated by experiments of planarians and by a new formulation of the morphogenetic field concept.


An atypical immunoglobulin A in benign monoclonal gammopathy.


Repair processes on deoxyribonucleic acid.


Toxicological problems relating to changes in the environment.


Molecular structure and biosynthesis of the fatty acid synthetase-multienzyme complex of yeast.


Studies of lipid A fractions from the lipopolysaccharides of Pseudomonas aeruginosa and Pseudomonas alcaligenes. Lipid A fractions from Pseudomonas aeruginosa and Pseudomonas alcaligenes have similar compositions and structural features. By means of hydrazinolysis of the parent lipopolysaccharides and partial hydrolysis of the deacylation products, it was established that both lipids are derived from the beta-(1-->6)-linked disaccharide of glucosamine. Phosphorylated derivatives of the disaccharide from Ps. aeruginosa were also characterized. The lipids differ mainly in the absence of hexadecanoic acid and 2-hydroxydodecanoic acid from the lipid from Ps. alcaligenes. Evidence that in Ps. aeruginosa these acids are ester-linked to residues of 3-hydroxyalkanoic acids (including 3-hydroxydecanoic acid) was obtained. Heterogeneity of lipid A fractions was indicated by t.l.c., and by gel filtration of de-O-acylation products from mild alkaline methanolysis of the lipids.


Blockage of highly-stable "kindled" seizures in rats by antecedent footshock.


Alumina cream-induced focal motor epilepsy in cats. 2. Thickness and cellularity of cerebral cortex adjacent to epileptogenic lesions.


Alumina cream-induced focal motor epilepsy in cats. 1. Lesion size and temporal course.


The significance of electroencephalographic paroxysms in children less than 3 years of age.


Genetic factors in spike-wave absences.

Genetic factors in spike-wave absences.


Effect of trypsin and ethylenediamine tetra acetic acid on the rate of adhesion of KB cells.


The effect of glibenclamide on non-esterified fatty acid levels in the plasma of the severely alloxan diabetic rat.


Antibodies to venous tissue in phlebothrombosis.


Production of lesions in various tissues by amino acids.


A simple procedure for detecting proteins synthesized in organ cultures.


Role of pili in the virulence of Neisseria gonorrhoeae. Gonococci of the colonial types that are associated with virulence, types 1 and 2, have pili that enable the bacteria both to attach in vitro to human epithelial cells and to resist phagocytosis by polymorphonuclear leukocytes. These piliated gonococci also agglutinate various mammalian and chicken erythrocytes. Gonococci of an avirulent colonial type, i.e., type 4, have no pili and neither attach to epithelial cells or erythrocytes nor resist phagocytosis. Like the type 4 bacteria, mechanically or enzymatically (trypsin) depiliated type 1 gonococci failed to attach to epithelial cells and erythrocytes and were susceptible to phagocytosis. Pili of types 1 and 2 gonococci were antigenically similar. Both type 1 gonococci and pili isolated from them induced in rabbits antibody that (i) precipitated gonococcal pili in immunodiffusion, (ii) reacted with piliated gonococci as tested by indirect immunofluorescent analysis, (iii) inhibited attachment of piliated gonococci to both human epithelial cells and erythrocytes, and (iv) opsonized piliated gonococci.


Local cerebral blood flow in experimental middle cerebral artery vasospasm.


Vascular compression of the duodenum following severe brain injury. Case report.


A re-examination of stereoscopic mechanisms in area 17 of the cat.


The time course of the cerebral circulatory response to metabolic depression.


The origin of life.

The origin of life.


Molecular hysteresis and its cybernetic significance.


The cytochalasans: a new class of biologically active microbial metabolites.


Iron-sulfur proteins: structural chemistry of their chromophores and related systems.


Ascending cholangitis after successful surgical repair of biliary atresia.


2-hydroxy-5-carbomethoxybenzyloxyamine: a new potent inhibitor of histidine decarboxylase.


Impaired performance of delayed matching in monkeys by heptabarbitone, pentobarbitone sodium and guinalbarbitone sodium.


The actions of histamine on blood flow and capillary filtration coefficient (C.F.C.) in the cat small intestine.


Excretion of catecholamine metabolites following intraventricular injection of 6-hydroxydopamine in the Macaca speciosa.


Evidence for multiple forms of receptors for amiloride in transporting epithelia.


Improved purification of rat brain choline acetyltransferase by using an immunoabsorbent.


Radiochemical assay of UDP glucuronyltransferase (p-nitrophenol).


Cytoplasmic transfer of RNA complementary to repetitious DNA sequences during early sea urchin embryogenesis.


Wildlife review. The effects of pesticides on British wildlife.


The survival of Brucella abortus in milk and milk products.


Chemotherapy with hydroxyurea, leucopheresis and splenectomy in the treatment of chronic myeloid leukemia at the problastic phase.


Causes and genesis of myeloid leukemia.

Causes and genesis of myeloid leukemia.


Chromosome alterations in chronic myeloid leukaemia, present aspects of the problem.


Chronic myelogenous leukemia: preleukemia or leukemia?


Chronic myeloid leukaemia: advances in cytochemistry.


Cell population growth in chronic myeloid leukaemia.


Clinical problems of preventive medicine. The prevention and control of infectious ovine abortion.


Observations on the cytokinetics of chronic myeloid leukaemia.


Blood coagulation abnormalities in chronic myeloid leukaemia.


Preliminary observations on a theilerial species pathogenic to cattle isolated from buffalo (Syncerus caffer) in Tanzania.


Immune reactions in chronic myeloid leukaemia.


Studies on the genesis of anemia in chronic myeloid leukaemia--in vitro response of bone marrow cells to erythropoietin.


A comparative essay of drugs in the treatment of chronic myeloid leukaemia.


Clinical pharmacology of dibromohexitols.


Dibromomannitol and chronic myeloid leukaemia results of a cooperative study.


New trends in the management of chronic myeloid leukaemia.


Treatment of the blastic phase of chronic myeloid leukaemia. A question to solve.


Therapeutic experiences in chronic granulocytic leukaemia.


Chronic myeloid leukaemia: course, life expectancy, and an analysis of dibromomannitol and busulfan treatment.


Therapeutic effect of the removal of leukocytes by cell separator.


Results in the treatment of chronic myeloid leukaemia.


The affinity of mycobacterial glycopetides for guinea-pig gamma immunoglobulin and its fragments.


Conglutinating activity in apparently healthy human and animal sera.


Cellular immunity in experimental glomerulonephritis of rats. II. A sequential study of immunological events occurring during development of the disease.


Purification and characterization of cytochrome b5-like hemoprotein associated with outer mitochondrial membrane of rat liver.


The potential use of high-performance liquid chromatography in residue analysis.


Studies on ribosomal ribonucleic acid from yeast. I. Isolation and characterization of anomalous heavier 30 S robonucleic acid.


An enzyme preparation inactivating all penicillins and cephalosporins. Commercial penicillinases vary in their capacity to destroy penicillinase-resistant penicillins and cephalosporins. A new freeze-dried preparation containing both beta-lactamase I and II was found to inactivate all penicillins and cephalosporins at levels above those likely to be encountered in clinical specimens.


An outbreak of diphtheria in a hospital for the mentally subnormal. An account is given of two separate outbreaks of diphtheria amongst mentally subnormal patients and nursing staff. In a total hospital population of about 1000 the number of people involved as carriers or cases was 60 and there were five deaths. The 60 people comprised 56 patients, of whom four were involved in both outbreaks, and four nurses. The organisms isolated were C. diphtheriae mitis but five strains were non-toxigenic. It is postulated that the outbreak began following the conversion of a non-toxigenic organism to a toxigenic one by bacteriophage action. The fatal cases were examples of membranous pharyngo-laryngo-tracheo-bronchial diphtheria with well marked pseudo-casts of the upper air passages.


Experimental hypercalcaemia and whole blood clotting. Experimental hypercalcaemia was induced in rats by (1) transplantation of the solid Walker 256 tumour, and (2) intraperitoneal injections of calcium gluconate. Whole blood clotting was studied by means of thromboelastography and whole blood clotting times in polystyrene and glass test tubes. At serum calcium levels between 10.3 and 11.5 m-equiv/l a slight delay in clot formation was found which was reversible by the addition of EDTA to whole blood. Acute, calcium-gluconate-induced hypercalcaemia, however, leads to a significant shortening of the clotting time in the polystyrene tube and to a lesser degree in the glass tube. Maximal factor XII activation in vitro with ellagic acid levels the difference of clotting times again. From these experiments it is concluded that acute hypercalcaemia induces a hypercoagulable state, possibly by partial contact activation, and thus may favour thrombus formation in vivo.


The enterohepatic circulation of bile acids as they relate to lipid disorders.


Measurement of myocardial blood flow by means of external counting method using 86-rubidium.


The catalytic mechanism of carbonic anhydrase. It is shown that an "inverse" relationship between the pH dependencies of the rates of hydration of CO(2) and dehydration of HCO(3) (-) by carbonic anhydrase (EC 4.2.1.1) is a direct consequence of the thermodynamic equilibrium between CO(2) and HCO(3) (-) and independent of any assumptions about the catalytic mechanism. It is further shown that proposed mechanisms for carbonic anhydrase involving HCO(3) (-) as the substrate in the dehydration reaction and a proton transfer reaction, EH(+) right harpoon over left harpoon E + H(+), as an obligatory step during catalysis obey the rule of microscopic reversibility. This includes mechanisms in which the proton dissociation is from a zinc-coordinated water molecule. Such mechanisms can be in accord with the observed rapid turnover rates of the enzyme, since rapid proton exchange can occur with the buffer components, EH(+) + B right harpoon over left harpoon E + BH(+). Mechanisms in which H(2)CO(3) is the substrate in dehydration avoid the proton-transfer step, but require that H(2)CO(3) combines with enzyme more rapidly than in a diffusion-controlled reaction. Physico-chemical evidence for and against a zinc-hydroxide mechanism is discussed.


Metabolic demands after surgery.

Metabolic demands after surgery.


Intravenous nutrition: the materials available.


Management of prolonged intravenous feeding.


Epidemiology of Chagas' disease and methods of detecting T. cruzi.


Immunology in cutaneous leishmaniasis.

Immunology in cutaneous leishmaniasis.


Transmission of hepatitis and Australia antigenaemia within a liver unit.


Caffeine contractures in depolarized heart muscle.


Clinical hypersensitivity states and serum protein modifications.


Coagulation of hyperglobulinaemic mink blood by glutaraldehyde.


Response to selection in synthetic lines of Drosophila melanogaster.


Right-sided bacterial endocarditis. New concepts in the treatment of the uncontrollable infection.


The respiratory chain of Azotobacter vinelandii. I. Spectral properites of cytochrome d.


Feedback controlling oxygen production in a cross-reaction between two photosystems in photosynthesis.


The turnover times of photosynthesis and redox properties of the pool of electron carriers between the photosystems.


The formation of pyrimidine dimers in the DNA of fungi and bacteria.


The management of radiation caries.

The management of radiation caries.


An investigation into the spread of bacterial infection in lower-limb amputations.


Silver phosphanilamidopyrimidine. A new silver sulfadiazine analogue effective against Pseudomonas infection in burned mice.


Cortical projection of group I muscle afferents to areas 2, 3a, and the vestibular field in the rhesus monkey.


Observations on the rates of ion movement and hypercapnia in aqueous humor.


Purification of the human complement protein C1q by affinity chromatography.


Expression of the a, x, and y variable region genes of heavy chains among IgG, IgM, and IgA molecules of normal and a locus allotype-suppressed rabbits.


Antigenicity of formaldehyde-inactivated staphylococcal enterotoxin B.


Detection of idiotypic determinants on human monoclonal proteins with specific rabbit antisera and hemagglutination-inhibition.


Perimenstrual aggression in groups of female rhesus monkeys.


The influence of the nucleolar organizer region on sperm utilization in Drosophila melanogaster.


Asymmetric transcription of SPP1 in vivo.


Dietary data and estimates of energy expenditure.


The effects of stimulants and depressants on cocaine self-administration behavior in the rhesus monkey.


Radiotherapy in the treatment of osteoarthrosis of the knee.


Respiratory disease in cork workers ("suberosis").


Light and electron microscopy of parathyroid carcinoma. Report of three cases.


Ectopical decidua formation in the ovary (so-called deciduoma).


Repair in arterial tissue. A scanning electron microscopic (SEM) and light microscopic study on the endothelium of rabbit thoracic aorta following a single dilatation injury.


Lateral pterygoid: two muscles?

Lateral pterygoid: two muscles?


Neurohistological observations on the heart of the Indian rhesus monkey, Macaca rhesus.


Lymphoid cells converted by lymphoid RNA extracts in vitro and in vivo to synthesize allogeneic immunoglobulins.


Interspecies "transfer" of delayed hypersensitivity in vitro with RNA extracts.


Lactase-phlorizin hydrolase complex from monkey small intestine: stimulation of phlorizin hydrolase activity by organic acids.


The use of glutaraldehyde fixation to analyze the mechanism of factor catalyzed reassociation of eukaryotic ribosomal subunits.


Dissociation of eukaryotic ribosomes by purified initiation factor EIF-3.


Isolation of carcinogenic aminoazo dye-binding protein and its identification as alcohol dehydrogenase.


Multiple DNA polymerase activity solubilized from higher plant chromatin.


Are interoceptive stimuli sufficient for instrumental conditioning?


Affinity chromatography of thermolysin and of neutral proteases from B. subtilis.


Nucleus-associated RNA in measles virus-infected cells.


Atomic coordinates for ferricytochrome c2 of Rhodospirillum rubrum.


Detection of biliary tract disease at operation.


The influence of sodium, potassium and lithium on the response of glycogen synthetase I to insulin and epinephrine in the isolated rat diaphragm.


Prepacked milk feeds for continuous intragastric feeding.


Cryopreservation of infective particles of Theileria parva.


The bacteriochlorophyll absorption band shifts linked with the energy state of photosynthetic bacteria membranes.


Electron microscopy of incontinentia pigmenti.


Kinetics of the two-sited enzyme. II. A method of distinguishing between anticooperative and independent active sites based on competitive inhibition.


Borna disease (BD), a slow virus infection. Biological properties of the virus.


Electron microscopy of intimal plaques following induction of large superficial mechanical injury (transverse injury) in the rabbit aorta.


Comparative microspectrophotometric study of the DNA content in the diagnosis of pre-tumorous processes and cancer.


On the presence of a concanavalin-A reactive coat over the endothelial aortic surface and its modifications during early experimental cholesterol atherogenesis in rabbits.


Cytoplasmic fusions between liver parenchymal cells and infiltrating cells in chronic aggressive hepatitis.


Cytogenetic studies in protein-calorie malnutrition.


Combining intra-abdominal arterial grafting with gastrointestinal or biliary tract procedures.


Intrajejunal administration of an elemental diet at neutral pH avoids pancreatic stimulation. Studies in dog and man.


Parenteral alimentation in infants and children with life-threatening illness.


Selective inhibition of phagocytic activity of rabbit alveolar macrophages by cystic fibrosis serum.


Computer files and analyses of laboratory data from tuberculosis patients.


Serum alpha 1-antitrypsin variants. Prevalence and clinical spirometry.


Glomerular changes in acute plasmodium falciparum infection. An immunopathologic study.


Organ-specific differences in the methylation of transfer RNA in vitro.


Radioassay of serum folate.

Radioassay of serum folate.


Oxidative activation of benz(a)anthracene and methylated derivatives in mutagenesis and carcinogenesis.


Scanning electron microscopy of human, monkey, and rabbit spermatozoa.


Monkey ovarian contractility--its relationship to ovulation.


Copper levels in tissues of rhesus monkeys bearing intrauterine or intra-abdominal copper devices.


Fertility of abnormal hemoglobin carriers in Porto Alegre, Brazil.


Blood groups, secretor status and ability to taste phenylthiocarbamide in some Muslim groups.


Immunoglobulin characteristics of antibodies to malarial S-antigens in man.


Oculomotor defects in cerebellectomized monkeys.


Structural changes in sheep antibody induced by interaction with polypeptide antigens.


Letter: Oculomotor control system.

Letter: Oculomotor control system.


The phagolysosomal system of the pigment epithelium. A key to retinal disease.


Platelet-induced vitreous membrane formation.


Laser trabeculotomy in monkeys.

Laser trabeculotomy in monkeys.


Yersinia pseudotuberculosis infection in a Siberian tiger and a spider monkey.


Undifferentiated salivary gland carcinoma in a baboon.


Renal carcinoma in a rhesus monkey.

Renal carcinoma in a rhesus monkey.


Intraocular echinococcosis in a rhesus monkey.


Indirect inguinal hernia in two baboons.


Dermatophilosis (cutaneous streptothricosis) in owl monkeys.


Pesticide effect on rumen microbial function.


Destruction of psychrophilic strains of Bacillus by chlorine.


Immunochemical and immunofluorescence studies of beta-trace protein in different species and organs, with special reference to the central nervous system.


Ultraviolet absorption characteristics of myelin from the central nervous system.


Inflammatory changes in the non-infected prostate gland. A clinical, microbiological and histological investigation. 36 patients (18 with chronic prostatitis and 18 with chronic urethritis) were studied to determine the incidence and nature of prostatic inflammatory changes in patients with clinically diagnosed chronic prostatitis and chronic urethritis without the occurrence of aerobic and anaerobic bacteria, Mycoplasms, and fungi or viruses in the prostatic tissue or prostatic secretion.  Excretory urography (IVP), cytoscopy and urethroscopy were performed on all patients.  Prostatic biopsy was done transperineally by the method of Veenema.  None of the biopsy specimens exhibited acute inflammatory changes.  Chronic inflammation in the form of infiltration around the acini with mononuclear inflammatory cells occurred without simultaneous infection in 17 cases.  Changes were slight in 11 cases, moderate in 5 and severe in 1.  No relationship was found between changes in the appearance of epithelium and occurrence of inflammatory changes. Causes of inflammatory reaction is not known.  Current research is being done to determine possible cell-bound hypersensitivity using lymphocyte migration technique.


Unilateral diverticulum of the ureter: a case report and scanning electron microscopic study.


Letter: RH sensitization associated with drug use.


Letter: Mechanism of host specificity in malarial infection.


Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types.


Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.


Cursive epilepsy and gelastic epilepsy.

Cursive epilepsy and gelastic epilepsy.


Antiepileptic therapy and rickets in children.


Applications of the electron beam in the treatment of cancer of the skin and lips.


Relative surface doses from supervoltage radiation.


Lung corrections for 8-MV X rays.

Lung corrections for 8-MV X rays.


Localization and content of thyrotrophin releasing factor (TRE) in median eminence of the hypothalamus.


Peripheral plasma levels of oestrogens, progesterone and 17alpha-hydroxyprogesterone during gestation in the rhesus monkey.


Peripheral plasma levels of oestrogen and progesterone in pregnant rhesus monkeys treated with dexamethasone.


Concordance of radioassay and microbiological assay in the study of the ethanol-induced fall in serum folate level.


Anticomplementary hepatitis B antigen. Prognostic importance in chronic active liver disease.


Peripheral control of hormone metabolism.


Protection with split and whole virus vaccines against influenza.


Letter: Pathogenesis of measles.

Letter: Pathogenesis of measles.


Plasma C3 and C4 concentrations in management of glomerulonephritis. As part of a larger study of serial complement profiles in glomerulonephritis plasma C3 and C4 concentrations were measured using commercially available immunodiffusion plates. A total of 303 samples were obtained from 128 patients suffering from forms of nephritis associated with hypocomplementaemia-namely, lupus nephritis, mesangiocapillary glomerulonephritis (M.C.G.N.), and acute glomerulonephritis.These simple measurements of C3 and C4 gave clinically useful information. In lupus nephritis C3 and C4 generally correlated and C4 concentrations were more often and more profoundly depressed than C3 concentrations. Neither C3 nor C4 concentrations alone correlated well with the antinuclear factor titre.In both acute glomerulonephritis and M.C.G.N. the C3 concentrations were frequently lower than 20% of normal (which was never the case in patients with lupus), while the C4 concentration was usually normal and was almost never depressed in the absence of C3 depression. This suggests activation of complement at the C3 level by the "bypass" pathway in acute nephritis as well as in M.C.G.N., though both may be operating in some patients. In acute glomerulonephritis but not in M.C.G.N. C3 concentrations returned to normal within eight to 12 weeks.The two varieties of M.C.G.N. identified by the site of the deposits in the capillary glomerular walls differed in their C3 levels. In 10 patients with intramembranous dense linear deposits the C3 was always low over very long periods of time, rising in three out of four patients only after transplantation and immunosuppression. Other patients with M.C.G.N., in contrast, often showed normal C3 concentrations. Concentrations of C4 did not differ in either group, being normal in 80% of samples from all types.


Letter: Prepacked milk feeds for continuous intragastric feeding.


Study on Saskatchewan community clinics suggests total health expenditure not less.


Study on Saskatchewan community clinics suggests total health expenditure not less. Report's data and interpretation suspect.


Resistance of Pseudomonas aeruginosa to gentamicin. The resistance to gentamicin 4 mug./ml. of 250 Pseudomonas aeruginosa isolates was measured by a proportion method. Twenty-eight (11.2%) of the cultures fell into the most resistant group, in whose populations between 10 and 100% of the organisms were resistant. A relatively high percentage of urinary isolates and a comparatively low percentage of isolates from respiratory sources occurred in this group. Three of the 28 were resistant to carbenicillin 150 mug./ml. and 6 of 18 tested were as resistant to gentamicin 8 mug./ml. as they were to 4 mug./ml. The distribution of Ps. aeruginosa isolates between the different grades of resistance did not change significantly during the 10 months in which the survey was performed.


Study on Saskatchewan community clinics suggests total health expenditure not less. Report fails to deal with incentive issue for clinics physicians.


Pharmacologic studies of camptothecin (NSC-100880): distribution, plasma protein binding, and biliary excretion.


A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo.


Motor behaviors of neonatal rhesus monkeys: measurement techniques and early development.


Reversal learning in the neonatal rhesus monkey.


Mother-infant separation in squirrel monkeys living in a group.


Plasma thyrotropin response to thyrotropin-releasing hormone in patients with pituitary and hypothalamic disorders.


Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide.


Immunization of female baboons with hapten-coupled gonadotropins. Female baboons (papio anubis) were immunized with gonadotropin preparations that had been structurally altered by hapten-coupling and the effects of such immunizations upon the events of the menstrual cycle were observed.  Antibodies were detected against the immunizing antigen within 3-5 weeks.  Cross-reaction of antibodies to sulphanil-azo-human luteinizing hormone (LH), human chorionic gonadotropin and ovine LH with unaltered baboon LH was marked only during the first 8 weeks, the period of immunoglobulin M (IgM) abundance, then  dropped sharply as the antisera shifted to nearly all IgG.  This drop did not occur with monkey and baboon immunizations.  Ovulation was disrupted for 2-3 months with human and ovine gonadotropin immunizations but sulphanil-azo-monkey or baboon LH caused anovulation for 4-8 months.  A reduction of hormone secretion correlated with titers of cross-reactivity.  This evidence suggested that hapten-coupling produced changes in gonadotropins with enhance their antigenicity and the cross-reactivity of antibodies raised to them.


Plasma thyrotropin and its response to thyrotropin releasing hormone in normal pregnancy.


Immunobiological entity of human leukemia reproduced in cayman.


Drinking as an avoidance response by the pigtail monkey (Macaca nemestrina).


Delayed recovery of function following orbital prefrontal lesions in infant monkeys. Monkeys given orbital prefrontal lesions at 1, 4, or 8 weeks of age exhibited a severe learning disability when they were tested at 1 year of age, but showed substantial recovery by the time they were 2 years old. These results suggest that the protracted maturation of intact cortical regions is important in recovery of function after early brain injury.


Letter: Carbon dioxide and pH: effect on species succession of algae.


The completion cholangiogram: failure to empty due to pseudo-obstruction.


Preoperative preparation of the colon with an elemental diet.


Temperature-sensitive mutants of toxinogenic corynebacteriophage beta. I. Genetics.


Properties of an oncornavirus glycoprotein: evidence for its presence on the surface of virions and infected cells.


In vitro action of bufexamac and selected hydroxamic acids on isolated rat liver lysosomes.


Effect of glibenclamide upon 45 calcium efflux from perifused islets.


Application of the radial immunodiffusion method to the study of IgG and the free light chains of immunoglobulins in the tubular and glomerular proteinuria.


The synthesis of nucleic acids in Bacillus subtilis infected with phage PBS 1.


Structural studies on antigen E of ragweed pollen.


Ocular abnormalities among congenitally deaf children.


Preventive treatment of tuberculin-negative contacts. Five children who had been in close contact with highly infectious tuberculous individuals presented recently to the tuberculosis service of The Montreal Children's Hospital. Four had developed serious pulmonary tuberculosis and one tuberculous meningitis, all within the three months which followed a post-contact negative tuberculin test.The management of tuberculin-negative children recently exposed to active infectious tuberculosis by repeated skin tests and chest radiography alone is inadequate for their protection. These children are at high risk of developing disease by the time their tuberculin sensitivity has become evident. It is inadvisable to vaccinate them with BCG until three months after their last exposure to the disease. A plea is made for preventive chemotherapy in these cases.


Diazepam and benzoctamlne: effects on certain objective parameters of muscular spasticity.


Flurazepam versus diazepam in an anaesthesia: a clinical study.


Comprehensive clinical studies with trazodone.


Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins.


A controlled study of the clinical effects of amantadine hydrochloride (Symmetrel).


The comparative effects of SE1520, frusemide, and cyclopenthiazide in healthy subjects.


Treatment of chronic staphylococcal osteomyelitis with minocycline hydrochloride: a case report.


Attempts at prophylaxis for murine Pneumocystis carinii pneumonitis.


Immunological properties of a trypanosomal lipopolysaccharide and its effects on the infection with Trypanosoma (Schizotrypanum) cruzi.


Quantitative aspects of the migration inhibition reaction.


Immunoadsorbent purification of antisera to impure abnormal serum antigens. Application to murine leukemia plasma virus.


A factor in respiratory tract secretions interfering with the ammonium sulfate test of Farr.


Transformation of lymphocytes in gonorrhea before and after therapy. Patients were studied for lymphocyte transformation responses to a variety of Neisseria gonorrhoeae antigens and to a Neisseria catarrhalis sonicate. Cells from infected patients manifested significant uptake of tritiated thymidine in response to one or more gonococcal antigens. In some cases, deoxyribonucleic acid synthesis was so marked in lymphocytes not challenged by antigens in vitro that added blastogenesis was either obscured or inhibited. At five weeks posttherapy, lymphocytes were relatively nonreactive to gonococcal antigenic stimulation. Blastogenesis in response to N. catarrhalis was also seen for a few gonorrhea patients and normal controls. Cross-antigenicity of catarrhalis organisms and gonococci was indicated by the disappearance of reactivity to catarrhalis sonicate by the lymphocytes of almost all convalescent gonorrhea patients.


Rubella immunization of volunteers via the respiratory tract. The efficacy of various routes of administration of the live attenuated rubella virus vaccine was evaluated by using 46 seronegative volunteers who were divided into 4 vaccine groups: subcutaneous, nosedrops, spray into posterior oropharynx and nose using large particle aerosol, and inhalation of small particle aerosol through the mouth. Seroconversion was observed in all of the vaccinees regardless of route of immunization. Nasal secretion antibody 6 weeks after immunization was highest in the volunteers who received the vaccine by nose drops (all members of this group had demonstrable nasal secretion antibody after immunization). Only half of the volunteers in the subcutaneous group developed demonstrable nasal secretion antibody. This suggests that nasal secretion antibody was best stimulated when vaccine was given directly into the nose. Volunteers were challenged with the vaccine intranasally at 6 to 8 weeks. None of the volunteers exhibited clinical symptoms or fourfold or greater serum antibody rises after challenge, but fourfold or greater nasal secretion antibody rises were observed in three volunteers in the subcutaneous vaccine group and two in the aerosol group, suggesting that those volunteers had not been protected against challenge. Rubella virus was isolated 8 to 12 days after challenge in two persons in the subcutaneous group and three in the aerosol vaccine group, but none in the nose drops or spray groups. Thus, protection after nasal challenge appeared to be best in those groups which also had the best nasal secretion antibody response after immunization. However, protection did not seem to be correlated with either nasal secretion or serum antibody levels.


Mechanisms of immunity in typhus infections. I. Multiplication of typhus rickettsiae in human macrophage cell cultures in the nonimmune system: influence of virulence of rickettsial strains and of chloramphenicol. Monocytes from the peripheral blood of nonimmune human subjects transformed in cell culture into macrophages with increased phagocytic capacity for killed typhus rickettsiae. When such cells were exposed to living virulent Rickettsia mooseri (Wilmington strain) or R. prowazeki (Breinl strain), or to the attenuated E strain of R. prowazeki, in the presence of medium containing normal human serum, all three strains readily entered the macrophage, but the subsequent fate varied according to strain and its virulence. Thus, R. mooseri grew readily to attain very high intracellular populations which eventually destroyed the macrophage in 3 to 5 days and escaped to infect other cells. Virulent R. prowazeki also grew at about the same rate for the first 2 to 3 days but then often abruptly ceased to multiply. Circumstantial evidence suggests a toxic effect on host cells by smaller numbers of R. prowazeki organisms than with R. mooseri. The attenuated E strain of R. prowazeki failed to grow in most cells and eventually disappeared, but did grow to substantial numbers in the very rare cell in some cultures, suggesting the presence of a few cells which may not be typical macrophages. The growth of R. mooseri in the macrophage cytoplasm was inhibited by chloramphenicol in the culture medium. When the drug was removed after 3 days, growth began after a lag period and assumed a normal rate.


Immunological quantitation of hepatic tryptophan oxygenase in endotoxin-poisoned mice. An apparent inhibition of induction of mouse hepatic tryptophan oxygenase by endotoxin has been reported previously, as evidenced by low catalytic activity. This could be due either to decreased tryptophan oxygenase levels or to inactivation of existing enzyme molecules. To resolve this question, the enzyme was quantitated immunologically in control and endotoxin-poisoned mice. Tryptophan oxygenase was purified and used as an antigen to prepare antienzyme antibodies. The antiserum was shown to be monospecific by immuno-electrophoresis. Addition of the antiserum to high-speed supernatant fluids of liver homogenates of control or endotoxin-poisoned mice resulted in precipitation of the enzyme. Radial immunodiffusion assays revealed that there was less enzyme in livers of mice that received 1 mean lethal dose of endotoxin. It was concluded that endotoxin interfered with the synthetic process that results in enhanced levels of tryptophan oxygenase.


Stimulation of anti-Brucella vaccination in mice by tetramisole, a phenyl-imidothiazole salt. The effect of tetramisole (hydrochloride of racemic 2, 3, 5, 6,-tetrahydro-6-phenyl-imidazo [2, 1-b] thiazole) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant. Immunity to Brucella abortus challenge was estimated by the reduction in number of B. abortus colonies per gram of spleen in those mice which escaped full immunization and also by calculation of mean infective doses for each group of mice. All tetramisole treatments significantly reduced the number of B. abortus live cells in spleen from infected mice. Tetramisole, injected twice (at the time of vaccination and 48 h later), induced a significant 3.5-fold increase of the protection brought about by Brucella vaccine alone. A single injection of 1.25 mg/kg at the time of vaccination resulted also in a significant increase of the immunity given by vaccination. No modifications of the vaccine potency were observed if tetramisole administration preceded vaccination. In such a mouse assay, tetramisole-induced stimulation was not accompanied by specific antibody increases, although measured by three serological tests.


Effect of heat-labile factors on the neutralization of vaccinia virus by human. The effect of unheated guinea pig and human prevaccination serum on the neutralization of vaccinia virus was studied. Enhancement of neutralization was found in all sera containing antibody and was more marked (20- to 150-fold) in sera obtained in the first weeks after primary vaccination than in sera from immune adults or cord sera (4- to 25-fold). The enhancing factor was thought to be complement because it was destroyed by heating and ethylenediaminetetraacetic acid treatment. The fresh serum-enhanced neutralization test represents a highly sensitive and specific test which can be applied to measure low levels of vaccinia antibody not detectable by other means.


Antibody responses to meningococcal polysaccharide vaccines. Over the past 4 years 19 lots of group C polysaccharide vaccine and five lots of group A polysaccharide vaccine have been tested for their immunogenicity in man. For each lot tested, groups of 18 to 50 men received 50 mug of vaccine subcutaneously. Sera were obtained prior to and 2 weeks after vaccination. The analytical and serological methods used in these studies were Sepharose 4B chromatography for the estimation of molecular size, the radioactive antigen binding assay, and the indirect hemagglutination (IHA) test for measuring the antibody response. Results have shown that the radioactive antigen binding assay is preferable to the IHA test as a measure of antibody response. Group C meningococcal vaccines have been highly stable when stored at 4 C in powdered form. All lots of group C vaccine tested to date have been of equal potency, with molecular weight varying from 520,000 to 2,000,000. Group A polysaccharides have been found to be unstable after 2 years of storage at 4 C. Optimal antibody response to the group A vaccines appears to be directly related to the molecular size of the preparation.


Resistance to Mycoplasma synoviae is bursal dependent. Bursectomizing small bursa line birds produced susceptibility to Mycoplasma synoviae. This suggested that M. synoviae is B cell dependent, but does not rule out a T cell effect.


A system of intravenous hyperalimentation.


A new approach to diverticula of the inner part of the second duodenum.


Predictive oncology. 1.

Predictive oncology. 1.


The fine structure of the retinal transient layer of Chievitz.


Is there a potential defect in the blood-retinal barrier at the choroidal level of the optic nerve canal?


Spectrofluorometric determination of carbidopa (L-(-)-alpha-hydrazino-3, 4-dihydroxy-alpha-methylhydrocinnamic acid) in plasma.


Treatment of gonorrhea. Tetracyclines.

Treatment of gonorrhea. Tetracyclines.


II. Transportation systems in the diagnosis of gonorrhea.


Acute alterations in the bactericidal capacity of rabbit alveolar macrophages following stress.


The role of diphosphonates in osteoporosis of disuse.


Purification and some properties of isocitrate lyase from Pinus pinea.


Biophysical characterization of a mitogenic erythro- and lympho-agglutinating phytohemagglutinin (PPHA) of Phaseolus vulgaris.


Performance under temporal schedules by monkeys with partial ablations of prefontal cortex.


Comparison of behavioral effects of nicotine, d-amphetamine, caffeine and dimethylheptyl tetrahydrocannabinol in squirrel monkeys.


Macromolecular synthesis and cell division in x-irradiated Tetrahymena.


Antibody and antibiotic action on Rickettsia prowazeki in body lice across the host-vector interface, with observations on strain virulence and retrieval mechanisms.


Amniotic fluid creatinine in the Rh-sensitized pregnancy.


Umbilical blood flow, cardiac output, and organ blood flow in the immature baboon fetus.


Epidemiology of hepatitis B antigen in Panama.


Effect of inotropic agents on canine trabecular muscle rendered highly permeable to calcium.


Glycogen of the brain and vital organs of monkeys recovering from systemic ischemia.


Pseudomonas aeruginosa contamination of hydrophilic contact lenses and solutions.


Retinal laser damage thresholds as a function of image diameter.


The free flap: composite tissue transfer by vascular anastomosis.


The effects of protein deprivation on dominance measured by shock avoidance competition and food competition.


Sialic acid deficiency of human red blood cells associated with persistent red cell, leucocyte, and platelet polyagglutinability.


Significance of large red blood cells.

Significance of large red blood cells.


Evaluation of spinal inhibitory activity in epilepsy by the H wave recovery curve.


Symposium: microsurgery of the outflow channels. Laboratory research.


Psychological studies of patients with epilepsy and popular prejudice.


Depamide in the treatment of epilepsy. A clinical trial.


Effect of head and body tilt on flicker-induced nystagmus in monkeys.


Dietary management of diverticular disease.


Homogeneous glycogen synthetase b from rat liver.


Bovine pyruvate kinases. I. Purification and characterization of the skeletal muscle isozyme.


Characterization of phycocyanin from Chromonas species.


Control of infectious hazards for the biophotographer.


Microsomal electron transport. The role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase in liver microsomal lipid peroxidation.


A new alpha-D-mannosidase occurring in Golgi membranes.


An in-vivo stimulatory effect of 3,3',5-tri-iodo-L-thyronine on polyphenol oxidase activity in an ascidian.


Prolactin release induced by synthetic thyrotrophin releasing factor in female rats.


Experimental infection of dogs and monkeys with two rabies serogroup viruses, Lagos bat and Mokola (IbAn 27377): clinical, serologic, virologic, and fluorescent-antibody studies.


Exotoxins of Pseudomonas aeruginosa. I. Factors that influence the production of exotoxin A.


Exotoxins of Pseudomonas aeruginosa. II. Concentration, purification, and characterization of exotoxin A.


Exotoxins of Pseudomonas aeruginosa. 3. Characteristics of antitoxin A.


Combinations of edetic acid and antibiotics in the treatment of rat burns infected with a resistant strain of Pseudomonas aeruginosa.


Brief communication: a continuous in vitro source of Herpesvirus saimiri.


Transformation of cell cultures as an indication of the carcinogenic potential of chemicals.


Side effects of spasmolytic agents in the monkey. Intracisternal phenoxybenzamine and phentolamine.


Hormonal regulation of rapidly labeled RNA in normal preneoplastic and neoplastic tissues of mouse mammary gland.


A single method for measuring total thyroxine and free thyroxine index in serum.


Antibody production in protein calorie malnutrition.


Oxalosis caused by aspergilus infection.


Letter: Effects of vitamin E: good and bad.


Letter: Serology of toxoplasmosis, isosporosis and sarcosporidiosis.


Prenatal hypothyroidism and brain composition in a primate.


pH-dependent changes in composition of carcinoembryonic antigen.


Ventilation of toad lungs in the absence of the buccopharyngeal pump.


Letter: Infection and transformation of bovine lymphoid cells in vitro by infective particles of Theileria parva.


Fetal infection of the baboon (Papio cynocephalus) with vaccinia virus.


Comparison of temperature and pH effects on cells, walls, and autolysin of Listeria monocytogenes.


Comparative effects of ovarian steroids on glycogen metabolism of rat, rabbit and guinea pig uterine tissue.


Early life nutritional deprivation: persistent alteration of blood and urine amino acids in mice.


Calcification and decalcification rates in vitro. A new technique.


Responses of rat kidney and toad bladder to the pentapeptide ring structures of neurohypophysial hormones.


Diamide: a new radiosensitizer for anoxic cells.


Diagnostic and prognostic value of some tests of autoimmune hemolytic anemia in diseases of the lymphoreticular system.


Anthrax in Iran.

Anthrax in Iran.


Oxymetholone treatment in hypoproliferative anaemia. I. Frequency of response.


Correlation between oestriol levels and serum iron-binding capacity in pregnancy.


Quantitative studies of macrophages in blood cultures in chronic lymphocytic leukaemia.


A new anomaly of platelet aggregation. A report of two families.


Thrombocytopathia with abnormalities in platelet release reaction. Some evidence for platelet factor 4 deficiency.


Screening of blood donors for hepatitis-associated antigen and antibody.


Automated seroagglutination test with Brucella and salmonella suspensions.


Implant with postoperative drain after evisceration.


The effect of tobramycin on Pseudomonas keratitis.


Selection of treatment in squamous carcinoma of the floor of the mouth.


Clinical evaluation of a 10 percent intravenous fat emulsion for parenteral nutrition in thermally injured patients.


Effects of estrogen upon bile: implications with respect to gallstone formation.


Total body potassium measurements as a guide to intravenous alimentation.


Effects of various gases on the survival of dried bacteria during storage. Salmonella newport and Pseudomonas fluorescens were dried together in papain digest broth and sucrose-glutamate, and stored in several gases at various water activities (a(w)) between 0.00 and 0.40 at 25 C for various periods up to 81 weeks. Both S. newport and P. fluorescens, dried in papain digest broth and stored in air, died rapidly if the conditions were very dry (0.00 a(w)) or moist (0.40 a(w)). Storage in carbon dioxide and argon gave greater survival than storage in air but lower survival than did storage in nitrogen or in vacuo. When the organisms were dried in a sucrose-glutamate mixture the differences between the gases were very small, and variations in residual water were less important. Of the inert gases, argon gave the best survival when the organisms were dried in papain digest broth, especially at 0.00 a(w); the survival in neon and krypton was lower and in xenon and helium it was much lower.


Rapid method for detection of Pseudomonas aeruginosa on MacConkey agar under ultraviolet light. A simple screening technique for the detection of Pseudomonas aeruginosa colonies by their fluorescence on MacConkey agar under ultraviolet light is proposed. From 306 nonlactose fermenting cultures screened under the ultraviolet light, 108 fluorescent isolates were obtained. These were screened biochemically, with 103 (94.8%) being verified as P. aeruginosa. From the 198 nonfluorescing cultures, only one suspected P. aeruginosa was isolated.


Continuous pressure monitoring in experimental obstructive hydrocephalus. I. The dynamics of acute ventricular obstruction.


The perforated diverticulum of the duodenum.


Continuous pressure monitoring in experimental obstructive hydrocephalus. II. The origin of undulating ventricular waves and periodic respirations.


The identification of a unique p-nitrophenol conjugating enzyme in guinea pig liver microsomes.


On porcine enterokinase. Further purification and some molecular properties.


On the relation of heavy metals to the activity and heat stability of alkaline phosphatase from human placenta.


Altered response to scrapie tissues in neurological disease. Possible evidence for an antigen associated with reactive astrocytes.


Experimental kuru in the chimpanzee. A neuropathological study.


Digitalis as an antianginal agent.

Digitalis as an antianginal agent.


Interstitial pulmonary fibrosis and von Recklinghausen's disease. An ultrastructural and immunofluorescent study.


Endobronchial tuberculosis.

Endobronchial tuberculosis.


Incontinentia pigmenti: a systemic genodermatosis with striking cutaneous findings.


Gonococcal infections in infants and children. Lessons from fifteen cases.


Surgical aspects of nontuberculous bacterial meningitis in infancy and childhood. The successful use of conservative surgery in management of some of its complications.


Some recent concepts on anterior pituitary control.


Suppression of chicken immunoglobulin ontogeny by F(ab')2 fragments of anti-mu chain and by anti-L chain.


Synthesis, intracellular distribution, and secretion of immunoglobulin and H-2 antigen in muring splenocytes. A/J spleen cells were labeled with [(3)H]leucine and at intervals thereafter were homogenized and separated into microsomes and cell sap. Ig and H-2 antigens were assayed in the cell fractions and cell supernatants using immunoprecipitation. In addition, cells labeled by enzymatic radioiodination were incubated to determine the rates of release of Ig and H-2 antigens from the surface. The results indicate that the majority of Ig and H-2 antigens remain membrane bound throughout their intracellular life. In contrast to Ig, H-2 antigens are neither secreted nor shed from the cell surface. It is suggested that Ig is a peripheral protein of the cell membrane, whereas H-2 antigens are integral ones. The release of Ig on a fragment of plasma membrane could occur at fixed cell surface areas that contain no H-2 antigens or from which they have migrated before release.


The enhancement of macrophage bacteriostasis by products of activated lymphocytes. It was reported previously that the incubation of normal guinea pig macrophages with partially purified products of activated lymphocytes resulted in altered macrophage function including increased cell adherence to culture vessels, spreading, phagocytosis, and glucose carbon-1 oxidation. Studies reported here demonstrate that such macrophages also exhibit enhanced bacteriostasis. Lymphocytes were stimulated with concanavalin A, the culture supernatant was chromatographed over Sephadex G-100 and the fraction of mol wt 25,000-55,000, rich in lymphocyte mediators, was cultured with normal guinea pig macrophages for 1-3 days. Macrophages incubated with fractions from unstimulated lymphocyte cultures served as controls. The resulting macrophage monolayers were infected with Listeria monocytogenes. Macrophages incubated with mediator-rich fractions exhibited 2- to 10-fold enhanced bacteriostasis compared to controls. Further studies indicate that this enhancement was attributable to intrinsic changes in the macrophages and not simply a consequence of the number of macrophages on the monolayers. The studies support the concept that macrophage bacteriostasis can be enhanced by lymphocyte mediators. However, macrophages, which have been preincubated directly with sensitive lymphocytes and antigen exhibit even greater bacteriostasis and sometimes bactericidal capacity, suggesting that either a labile lymphocyte factor or direct lymphocyte macrophage interaction may also be involved in bactericidal activity.


Comparative activity of bacterial beta-lactamases on penicillins and cephalosporins.


Monoclonal macroglobulinemia in NZB-NZW F1 mice. Serum monoclonal macroglobulins were detected in over 30% of NZB/NZW F(1) mice greater than 11 mo of age. The monoclonal nature of the IgM was shown by restricted electrophoretic mobility, characteristic appearance on immunoelectrophoresis, restriction to a single light chain type, and ability to induce anti-idiotypic antisera. The monoclonal macroglobulins were separated from antibodies to DNA and RNA that migrated in the 7S region of sucrose gradients. Enlarged lymph nodes were often present in mice with monoclonal IgM, and a transplantable IgM-producing lymphoid tumor was established from the spleen of one animal.


In vitro activity of cefazolin against recent clinical bacterial isolates.


Studies on therapy of staphylococcal infections in monkeys. 8. Comparison of cephalothin, cephaloridine, cefazolin, cephacetrile, and cephanone.


Cefazolin in the treatment of gonorrhea.


Tularaemic pneumonia: pathogenesis of the aerosol-induced disease in monkeys.


Cefazolin in the treatment of uncomplicated gonorrhea in men.


The natural history of platelet-rich mural thrombi in systemic arteries of hypercholesterolaemic monkeys: light- and electron-microscope observations.


A clinical and histologic assessment of subperiosteal implants.


Short small-bowel syndrome.

Short small-bowel syndrome.


The effect of human granulocyte elastase on bacterial suspensions.


Microbiological studies on non-gonococcal urethritis in Brisbane.


Prophylaxis against septicaemia in acute leukaemia: the use of oral framycetin.


Cromolyn sodium.

Cromolyn sodium.


Intramembranous particle aggregation in lymphoid cells.


Prostaglandin production and bone resorption by dental cysts.


Gammopathy in hamsters with xenogeneic tumours.


The transmission of Sarcocystis tenella in sheep.


The effect of heterologous anti-thymocyte serum upon the course of infection with Trypanosoma cruzi in Mice.


The intranuclear development of Toxoplasma.


Studies on colostral antibodies to Theileria parva using the indirect fluorescent antibody test.


Chagas' heart disease. First demonstrable correlation between neuronal degeneration and autonomic impairment.


Left ventricular function in patients with coronary artery disease.


Myocardial transit times from intracoronary dye-dilution curves in normal subjects and patients with coronary artery disease.


Renovascular hypertension in the pediatric patient.


Development of large-scale fractionation methods. IV. A simple method for the large-scale preparation of alpha1-acid glycoprotein.


Tactile discrimination performance in the monkey: the effect of commissure section on transfer of training between the hands.


Effect of neuroleptics on aggressive behavior.


Studies on the biosynthesis of malate dehydrogenase isozymes in rabbit liver. Isolation of the in vivo labelled isozymes by specific antibodies.


Hydrosoluble adjuvant-active mycobacterial fractions of low molecular weight.


Genetic control of insect population. I. Cage studies of chromosome replacement by compound autosomes in Drosophila melanogaster. A genetic method for insect control was evaluated using the test organism, Drosophila melanogaster. The technique involved the displacement under a system of continuous reproduction, of standard strains by those carrying compound autosomes. The eradication of the replacements could subsequently be achieved through the use of temperature-sensitive lethal mutations.-While certain compound autosome strains failed to displace standards in population cages, even at the initial release ratio of 25:1, others were highly successful. Indeed, for some strains when the ratio of compounds to standards was as low as 9:1, the population rapidly went to fixation in favor of the compound line.-Hatchability was found to be an insufficient index of fitness to estimate the initial ratios of compounds to standards that would guarantee fixation of the former. Differences in other fitness components, such as development time, were detected that could seriously modify displacement, especially with continuous overlapping generations. The importance of examining the fitness of various compound lines and selecting the most competitive in cages, prior to field tests, cannot be overemphasized.


Differential response to selection on the two sexes in Drosophila melanogaster. Artificial selection for short wing was performed in two Drosophila melanogaster populations with partially different gene pools: the C populations were derived from a Canton stock while the H lines were derived from a cross between Canton and a b, cn, vg strain. It is shown that in both populations selection on females (CF, HF) was more effective than selection on males (CM, HM). This difference cannot be explained in terms of differences in additive genetic variability between the two sexes because: (1) both sexes contribute to the genetic variability utilized by selection applied to one sex only, and (2) switching selection pressure on females in the M lines does not result in a response comparable to that obtained in the F populations; this rules out almost completely recombination as the responsible agent for the differences between the selection limits reached by M and F selections.-These results, together with several additional observations concerning sexual dimorphism, fitness and the effect of natural selection, suggest that a complex interaction should be involved in the differential response of M and F lines, controlling the wing length phenotype.


A convenient method for liquid scintillation counting of barium carbonate-14C.


Anthrax in Louisiana, 1971: an evaluation of the Sterne strain anthrax vaccine.


Pharmacological comparison between tolbutamide and two second generation hypoglycemic sulfonylureas (glibenclamide and glisoxepide).


On the genetics of the primary generalized epilepsy with sporadic myoclonias of impulsive petit mal type. A clinical and electroencephalographic study of 399 probands.


Anthrax in Louisiana, 1971: epizootiologic study.


Electroencephalographic correlates of delayed-alternation and visual discrimination learning in rhesus monkeys.


A gas chromatographic method of quantitating DDT in the presence of interfering polychlorinated biphenyl.


Isolation of glucosamine from the capsids of a picornavirus.


Long term infection of diploid African green monkey brain cells by Schwarz measles vaccine virus.


Anthrax. Biological and immunological principles of diagnosis and prevention. Communication 7. Diagnosis of anthrax by means of anthraxin.


Effect of glucose or glycerin in cultivation media on the fatty acid composition of Listeria monocytogenes.


Localization of calcium antimonate in the atrial and ventricular muscle fibers of the cat heart.


Serum immuno-globulins in children with bilharzial infection.


Transmission of three strains of Plasmodium falciparum from monkey to man.


Studies on human malaria in aotus monkeys. 3. Exoerythrocytic stages of the Salvador II strain of Plasmodium vivax.


Difference in surface charge between host cells and malarial parasites.


Failure of holothurin to significantly affect Chagas' disease in mice.


Effect of progesteroids on the cellular response to inflammation in the monkey.


Virulence of rifampicin-resistant mutants of Shigella and enteropathogenic Escherichia coli with special reference to their cell invasiveness.


Slime production by Pseudomonas aeruginosa. 3. Purification of slime and its physicochemical properties.


Triazenes, a new group of indirect mutagens. Comparative investigations of the genetic effects of different Aryldialkyltriazenes using Saccharomyces cerevisiae, the host-mediated assay, Drosophila melanogaster, and human chromosomes in vitro.


Comparative mutagenic activity and toxicity of triethylphosphate and dichlorvos in bacteria and Drosophila.


Invited discussion: Approaches to the serologic characterization of Hodgkin's disease.


Invited discussion: Tumor-associated antigen in Hodgkin's disease.


Complications of intensive megavoltage radiotherapy for Hodgkin's disease.


Modern radiotherapy in carcinoma of the larynx.


Endoscopic treatment of esophageal diverticula.


Physicochemical investigation of DNP preparations obtained at low ionic strength.


Glycogen metabolism of human diploid fibroblast cells in culture. I. Studies of cells from patients with glycogenosis types II, 3, and V.


Meningococcal meningitis presenting as acute cerebellar ataxia.


Mucolipidosis 3 (Pseudo-Hurler polydystrophy): multiple lysosomal enzyme abnormalities in serum and cultured fibroblast cells.


Inactivation of enzymes induced by substrate: a model and some considerations.


Primer activity of a low molecular weight glycogen from a patient with an unusual glycogen storage disease.


Differentiation in Nostoc muscorum: nitrogenase is synthesized in heterocysts. Cellular differentiation can be observed in certain filamentous blue-green algae after transfer of the cells from medium containing NH(4) (+) or NO(3) (-) to nitrogen-free medium. The appearance of differentiated cells (heterocysts) is accompanied by an increase in the activity of nitrogenase, an enzyme complex that reduces N(2) to NH(3). We have separated vegetative cells from heterocysts in differentiated filaments of Nostoc muscorum, and analyzed their proteins by polyacrylamide-gel electrophoresis. The pattern of incorporation of (35)SO(4) (-) into proteins of the two cell types during differentiation indicates that the increase in nitrogenase activity is due to the de novo synthesis of nitrogenase proteins predominantly, if not exclusively, in heterocysts.


Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis. Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate synthetase (EC 2.7.6.1) is 2.5- to 3.0-fold higher than among normal people. The molecular basis for this increased enzyme activity was studied. Antibody to purified human phosphoribosylpyrophosphate synthetase of erythrocytes was obtained from immunized rabbits. Studies with the IgG fraction of this antiserum show the presence of normal quantities of immunoreactive enzyme, but 2.5- to 3.0-fold higher activity per molecule in affected members of the B. family. In addition, by use of a stain for phosphoribosylpyrophosphate synthetase activity, a difference in electrophoretic mobility was demonstrated on cellulose acetate gel between the partially purified enzyme from normal people and an affected member of the B. family. These studies suggest that the enzyme aberration responsible for purine overproduction and gout in the B. family results from a structurally altered enzyme with increased activity per molecule.


Strychnine binding associated with glycine receptors of the central nervous system. [(3)H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 muM, respectively.


Proton-coupled accumulation of galactoside in Streptococcus lactis 7962. When cells of the anaerobe Streptococcus lactis 7962 are deprived of their normal fermentable energy source, active transport of galactosides is completely abolished although the membrane carriers are still capable of facilitating the equilibration of sugars across the cell membrane. In these nonmetabolizing cells it was possible to test the Mitchell hypothesis of obligatory coupling of proton movement with sugar transport. This hypothesis was supported by alkalinization of the medium observed when thiomethylgalactoside was added to a lightly buffered suspension of S. lactis cells. Conversely, addition of protons resulted in active transport of thiomethylgalactoside. Accumulation of thiomethylgalactoside to a concentration more than 20-times that in the external medium was induced by suddenly exposing cells to a medium at pH 6; no accumulation of thiomethylgalactoside was observed with cells exposed to pH 8.Active transport of thiomethylgalactoside occurred in the absence of energy metabolism when S. lactis cells were treated with valinomycin. This ionophore allowed intracellular K(+) to flow out, thus imposing a membrane potential (inside negative). This potential resulted in a proton uptake and an associated active transport of galactoside. The membrane potential was measured from the distribution ratio (inside/outside) of K(+) in the presence of valinomycin. The pH gradient was measured from the distribution ratio of [(14)C]methylamine. The protonmotive force, calculated from the membrane potential and the pH gradient, was found to be directly related to the accumulation of galactoside, in accordance with the chemiosmotic hypothesis.


Survey of DNA polymerase activity during the early development of Drosophila melanogaster. The pattern of DNA polymerase activity in developing Drosophila melanogaster has been studied in seven stages of embryonic development as well as in unfertilized eggs. The crude polymerase-containing extracts, most likely of cytoplasmic origin, utilize, in the following order of decreasing template efficiency, "activated" calfthymus DNA, poly(A).oligo(dT), and poly(A).oligo(U). The highest enzymes levels occur in unfertilized eggs; the activity remains high during the first 9 hr of embryogenesis, but shows a progressive decline in the later stages. Deoxyribonuclease exhibits a similar trend. The unfertilized eggs of two genotypically different females had nearly identical levels of DNA polymerase.


Relation of detergent HLB number to solubilization and stabilization of D-alanine carboxypeptidase from Bacillus subtilis membranes. The ability of various nonionic detergents to solubilize D-alanine carboxypeptidase and other membrane-bound enzymes was correlated to a physical property of the detergent, the HLB number. Only a fairly narrow range of detergents were effective solubilizing agents. Purified carboxypeptidase required either a detergent or detergent plus a lipid fraction for stability. Only those detergents effective in solubilizing the enzyme were effective in stabilizing it.


Australia antibody production elicited by heat-treated human plasma protein solution.


The production in the pregnant cow of anti-human immunoglobulin to be used for the antiglobulin test.


Evidence of the existence of the rhesus complex Cde (r') in a Chinese.


The treatment of angina pectoris.

The treatment of angina pectoris.


Sequenced external counterpulsation and intraaortic balloon pumping in cardiogenic shock.


Central effects of 6-hydroxydopamine.

Central effects of 6-hydroxydopamine.


Visual defect does not produce stereotyped movements.


A statistical method for the classification of behavior untis occurring in primate communication.


Comparative methods for isolation of polysomes from the oviduct of laying hen.


Studies on the bacteriophage MS2. XXII. Conformation of MS2 RNA in acid medium.


The ribosomal cycle in bacteria treated with an inhibitor of protein synthesis.