Subtype of affective psychoses classified by response on amineprecursors and monoamine metabolism.


Synthesis and resolution of vinylglycine, a beta,gamma-unsaturated alpha-amino acid.


Synergistic action of increased oxygen tensions and PABA-folic acid antagonists on bacterial growth.


T cell recognition of cell-surface antigens. II. Antigen recognition is necessary yet not sufficient for triggering T cell-mediated immunity.


Synthesis of RNA by Escherichia coli RNA polymerase on the chromosomes of Drosophila melanogaster.


Target calcifications of the spleen in chronic brucellosis (Brucella suis).


Temperature-sensitive bobbed mutants in Drosophila melanogaster.


Terrestrial adaptations in the hands of Cercopithecinae.


The actions of narcotic antagonists in morphine-dependent rhesus monkeys.


Synaptic alterations in developing cortical infarction: an experimental investigation in monkeys.


Surgical correction of subglottic stenosis of the larynx in infants and children. Progress report.


The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. We have investigated whether mammalian cells can repair pyrimidine dimers in their mitochondrial DNA which have been induced by ultraviolet light. The assay system is based upon the ability of the phage T4 UV endonuclease to nick covalently closed circular mitochondrial DNA that contain pyrimidine dimers. Our results show that dimers are not removed from the mitochondrial DNA of mouse L cells or human KB and HeLa cells. There is also no evidence for photoreactivation of mitochondrial DNA. Analyses of ethidium bromide-cesium chloride equilibrium density gradients of mitochondrial DNA isotopically labeled before and after exposure to ultraviolet light show that the total amount of DNA replication is depressed after exposure. In addition, an increase in the frequency of molecules banding at a position expected for intermediate replicating forms and open circular daughter molecules suggests that the rate of replication is slower (or arrested) in molecules with pyrimidine dimers. The absence of a significant amount of mixing of label incorporated before and after ultraviolet-irradiation is evidence against the occurrence of a large amount of genetic exchange between mitochondrial DNA molecules under these conditions.


The activation of Cls with purified Clr.


The anti-Rho(D) responses of immunized volunteers following spaced antigenic stimuli.


The antibody response to different measles virus antigens under various conditions of immunization.


The barrier function of the gram-negative envelope.


The cancer syndrome.

The cancer syndrome.


The cat eye syndrome.

The cat eye syndrome.


The cerebro-oculo-facio-skeletal syndrome.


The characterization of ribosomal subunits of eukaryotes by ultracentrifugal techniques. Criteria of purity.


The circular dichroism of a Drosophila melanogaster satellite DNA.


The application of an indirect method of infecting ticks with piroplasms for use in the isolation of field infections.


The decline of cell-mediated immunity in aging mice.


The concentrations of progesterone, estrone and estradiol-17 beta in the peripheral plasma of the rhesus monkey during the final third of gestation, and after the induction of abortion with PGF 2 alpha.


The double hemidesmosome: a new intercellular junction (1).


The ecology of chigger-borne rickettsiosis (scrub typhus).


The effect of ambient temperature on the anti-D assay using the Auto-Analyzer. Using the AutoAnalyzer, the percentage agglutination effected by the anti-D antisera studied showed a varied dependence on the ambient temperature over the manifold subsequent to the incubation period at 37 degrees C. This leads to assays which are a function of the ambient temperature. It is suggested that the entry of a relatively large volume of rouleaux-dispersing agent results in an elution of bound antibody to a new position of equilibrium, the shift being dependent on the particular equilibrium constant of the antibody and the rate of its attainment on the ambient temperature. A constant ambient temperature will lead to greater accuracy of anti-D assay.


The effect of dopamine on gastric adrenergic receptors in the goat.


The effect of different serum concentrations of antimicrobial agents on the Lactobacillus casei folate assay.


The effect of efferent duct ligation on the uptake of 65-ZN by the epididymis and vas deferens of rhesus monkeys (Macaca mulatta). A study dealing with the uptake of zinc-65 by different segments of the epididymis and vas deferens of the rhesus monkey (Macaca mulatta) in the presence or absence of spermatozoa is reported.  It was determined that zinc-65 uptake by the vas deferens of the control side was significantly higher than that of the epididymal segments (vas deferens vs. caput, proximal and distal corpus, or cauda, p less than .01).  Amon g the epididymal segments themselves there was no significant difference .  Efferent duct ligation consistently reduced the uptake of zinc-65 in all portions of the epididymis and vas deferens (control vs. ligated: caput, corpus, cauda, and vas, p less than .01).  The percentage reduction in the uptake by different segments of the epididymis and vas remained virtually constant in the ligated side (caput, 57%; proximal corpus, 53%; distal corpus, 64%; cauda, 55%; vas deferens, 55%).  Nevertheless, zinc-65 uptake by vas continued to be significantly greater than that of the epididymis.  It is noted that the reduced zinc-65 accumulated on the ligated side could at least be partly due to absence of spermatozoa.  It is further suggested that the lowered uptake of zinc-65 by the epididymis and vas deferens following efferent duct ligation in the monkey may be also due to a local androgen deficiency.


The effect of hydergine on the transit time of cerebral circulation in diffuse cerebral insufficiency.


The effect of inferotemporal lesions on memory for visual stimuli in rhesus monkeys.


The effect of intragastric pH variations on the gastric acid response to sham feeding in duodenal ulcer patients.


The effect of insulin on the permeability of phosphatidyl choline bimolecular membranes to glucose.


The effect of minocycline on Candida albicans. Minocycline, a new tetracycline derivative, was found to inhibit the growth of Candida albicans. Inhibition was much affected by the composition of the medium and was difficult to demonstrate in fluid cultures. Study of the rate of budding in shallow broth cultures in Petri dishes showed that the addition of 20 mug/ml minocycline prolonged the lag phase by three hours. C. tropicalis was similarly inhibited and C. guilliermondii and C. parapsilosis to a lesser degree. Six other tetracyclines were tested and found to inhibit Candida only in very high concentrations.


The effect of propranolol on left ventricular function in angina pectoris as measured by systolic time intervals.


The effect of species-specific vocalization on the discharge of auditory cortical cells in the awake squirrel monkey. (Saimiri sciureus).


The effect of sulphur dioxide on oxidising enzyme systems in plant tissues.


The electrocardiogram of the Japanese (Coturnix coturnix japonica) and Bobwhite (Colinus virginianus) quail.


The function of the bladder neck in female goats.


The erythrocyte sedimentation rate in Rh-positive and Rh-negative donors.


The genes for ribosomal ribonucleic acid.


The genetics of Penicillium chrysogenum.


The hypocalcaemic effect of toluidine blue in sheep.


The histochemical demonstration of hydrolytic enzymes in adjuvant-induced arthritis in rats.


The goose that laid the golden bile: gallstone dissolution in man with chenodeoxycholic acid.


The influence of pure polychlorinated biphenyl compounds on hepatic function in the rat.


The effect of synthetic thyrotropin releasing hormone (TRH) on cell proliferation of the anterior pituitary gland in organ culture. Preliminary report.


The influence of stereochemical factors on drug disposition.


The inhibition by somatostatin of the thyrotropin response to thyrotropin-releasing hormone in normal subjects.


The isolation and partial characterization of sulfonamide-resistant carbonic anhydrases from the liver of the male rat.


The kinetics of substrate-competitive inhibition in ternary-complex mechanisms for enzyme reactions involving two substrates.


The isolation of symbiotic streptococci.


The late effects of neonatal hyperthyroidism upon the hypothalamic-pituitary-thyroid axis in the rat.


The long term care of the patient suffering from cerebral palsy. 3.


The long-term effects of marginal protein-energy deficiency.


The measurement of systolic time intervals by echocardiography.


The multi-step cancer therapy concept with time-optimal post-therapy Theoretical aspects.


The membrane association and dissociation of human glyceraldehyde-3-phosphate dehydrogenase under various conditions of hemolysis. Immunochemical evidence for the lack of binding under cellular conditions.


The nature and time of occurrence of radiation-induced nondisjunction of the acrocentric X and fourth chromosomes in Drosophila melanogaster females.


The neurological mechanisms of pain. A review.


The occurrence in sera with m-components of different proteins related to amyloid fibrils.


The president's page: health care delivery.


The physiology of mould-yeast dimorphism in the genus Mycotypha (Mucorales).


The problem of cultivation of Mycobacterium leprae. A review with criteria for evaluating recent experimental work. Some criteria are presented to help evaluate papers appearing in the literature claiming successful cultivation of M. leprae either in the absence or in the presence of tissue-cultured cells. Recently, electron microscopic studies have definitely shown M. leprae to belong to the genus Mycobacterium and its division to occur through transverse section. A survey is given of the mycobacterial strains isolated in the last 10 years from leprosy lesions. These strains belong to taxonomically different species and cannot be considered to be M. leprae. No substantiated claim was made concerning the in vitro growth of M. leprae and the application of the tissue culture technique has been equally disappointing. The view is expressed that progress towards the in vitro cultivation of M. leprae can be made only as a result of increased knowledge about the intracellular environment and the metabolic activities of this organism, to be obtained by the application of modern biochemical and histochemical techniques.


The processing of edge information in visual areas of the cortex as evidenced by evoked potentials.


The protection of mice by a specific anti-Erysipelothrix insidiosa-neuraminidase-antiserum against Erysipelothrix insidiosa infection.


The purification and some properties of brewer's yeast apotransketolase.


The purification of the DNA polymerase from Micrococcus luteus.


The red crowned mangabey, Cercocebus torquatus, in western Nigeria.


The rejection of malignant and non-malignant homografts: a new hypothesis.


The relation between nutritional deprivation and immunity.


The response of the heterotopic pituitary to thyrotropin releasing hormone (TRH).


The risks associated with treatment in the African diabetic.


The role of bicarbonate in proximal tubular sodium chloride transport.


The sensitivity of the Rh--anti-Rh system to ordered water of hydration.


The solution of the paradox of psychotherapy and its corollaries.


The specificity of anti-galactocerebroside antibody and its reaction with lysolecithin-solubilized myelin.


The synthesis and distribution of DNA in the macronucleus of Euplotes eurystomus.


The synthesis of phospholipase C by Bacillus cereus. II. A screening method for mutants.


The treatment of unstable ankle fractures.


The transplacental passage of thyroxine and foetal thyroid function in the rat.


The use of an ultrasonic bath to disrupt cells suspended in volumes of less than 100 micro liters.


The role of the mental health practitioner in long-term medical treatment.


The use of bovine carotid grafts for hemodialysis and hyperalimentation.


The utilization of 2-ketogluconate by Hydrogenomonas eutropha H 16.


The vitamin A transporting system in porcine plasma.


The vascular lesions of neurofibromatosis.


The wheat embryo cell-free system.

The wheat embryo cell-free system.


The Law and force-feeding.

The Law and force-feeding.


The Sargenti revival.

The Sargenti revival.


Thiosulphate compleximetric determination of bismuth in some organic pharmaceutical chemicals.


Theory for the sequence of human and rat enamel dissolution by acid and by EDTA: a correlated scanning and transmission electron microscope study.


Thrombocythemia and myocardial ischemia with normal coronary angiogram.


Thymectomy and bursectomy in chickens with simultaneous experimental and spontaneous autoimmune disease.


Thyrotropin-releasing hormone (TRH): distribution in hypothalamic and extrahypothalamic brain tissues of mammalian and submammalian chordates.


Topology of the caudal fat body of the tumor-w mutant of Drosophila melanogaster.


Tissue response to cryosurgery of oral cavity in rhesus monkeys.


Toxicity of aerosol propellants in the respiratory and circulatory systems. IV. Cardiotoxicity in the monkey.


Toxicity of halogenated oxyquinolines in dogs. A clinical study. II. History, symptoms, laboratory findings, therapy, and follow-up.


Toxicologic studies of four fluorescent whitening agents.


Transient diabetes insipidus in a newborn infant.


Transmission of parotin through the sacs of everted intestine and its demonstration in mesenteric perfusate.


Transmission of Plasmodium fragile to Aotus trivirgatus monkeys.


Total cerebral blood flow in the monkey measured by hydrogen clearance.


Transpeptidases and D,D-carboxypeptidases in bacilli.


Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours.


Total intravenous hyperalimentation in the management of cecal fistulas: Report of two cases.


Trisomy D in bone marrow cells in a patient with chronic myelogenous leukemia.


Triple tetracycline in lower respiratory tract infections.


Trisomy 18 mosaicism in two siblings.

Trisomy 18 mosaicism in two siblings.


Triterpenoid carotenoids and related lipids. The triterpenoid carotenes of Streptococcus faecium UNH 564P. 1. The occurrence of a novel series of triterpenoid carotenes in Streptococcus faecium UNH 564P is reported. 2. This series, which comprises the C(30) analogues of phytoene, phytofluene, zeta-carotene, 7,8,11,12-tetrahydrolycopene and neurosporene, appears to be analogous to the C(40) Porter-Lincoln series and a pathway of triterpenoid carotene dehydrogenation is proposed to account for the formation of these compounds. 3. Two cis isomers of the C(30) analogue of neurosporene are described. 4. An appropriate system of nomenclature for these novel compounds is proposed.


Triterpenoid carotenoids and related lipids. Triterpenoid monohydroxy- and monoglucosyloxy-carotenoids from Streptococcus faecium UNH 564P. 1. The characterization of two novel triterpenoid xanthophylls occurring in Streptococcus faecium UNH 564P is described. 2. Both are derived formally, and probably biosynthetically, from the C(30) analogue of neurosporene and have been identified as 4-hydroxy-4,4'-diaponeurosporene and its glucoside, 4-d-glucopyranosyloxy-4,4'-diaponeurosporene. 3. Problems associated with the use of specific glucosidases in defining the anomerism of carotenoid glucosides are discussed.


Tryptic fragments of Fc from normal human IgG and their interaction with staphylococcal protein A.


Tuberculous perforation of the small intestine.


Two methodological problems.

Two methodological problems.


Two methods of extraction and partial purification of Drosophila melanogaster RNA polymerase.


Two-dimensional polyacrylamide gel electrophoresis for separation of ribosomal proteins.


Two types of molecular evolution. Evidence from studies of interspecific hybridization. To assess the significance of macromolecular sequence differences among species, we compared the serum albumins of 81 pairs of vertebrate species capable of producing viable hybrids. Micro-complement fixation experiments showed that the average difference between the albumins within such pairs was only 3 immunological distance units for placental mammals (31 pairs), but 36 units for frogs (50 pairs). Albumin immunological distance is strongly correlated with other measures of genetic distance, including those made with DNA annealing techniques. It therefore seems likely that mammalian species pairs capable of hybridization are far more similar at the macromolecular sequence level than is the case for most hybridizable frogs. We think the most likely explanation for the marked molecular restriction on hybridization among mammals is that the ratio of regulatory evolution to protein evolution is higher for mammals than for frogs. Mammals may have experienced unusually rapid regulatory evolution; indeed, this could be the factor responsible for their unusually rapid anatomical evolution.


Two-step inhibition of Bacillus cereus penicillinase by dicloxacillin.


Ultra-structure, in vitro cultivation and metabolism of cells isolated from arthritic human bone.


Ultrahistochemical demonstration of calcium ions by a freeze-substitution method.


Ultrasonography of the chest wall.

Ultrasonography of the chest wall.


Ultrastructural study of liver cell injury due to UTP deficiency.


Ultrasound and scintigraphy in the differential diagnosis of obstructive jaundice.


Unusual metabolism of caffeine in the squirrel monkey.


Uptake and subcellular distribution of vitamin B12 in mouse L1210 leukemic lymphoblasts.


Urban rodent-borne disease and rodent distribution in Israel and nighboring countries.


Use of microculture plates and the multiple automated sample harvester for in vitro microassay of bacterial toxins. An in vitro cytotoxicity microassay for the measurement of nanogram quantities of Pseudomonas aeruginosa exotoxin and Vibrio cholerae enterotoxin is described.


Use of central and peripheral temperature measurements in care of the critically ill child.


Use of the single radial diffusion technique for influenza antibody surveys. A survey of antibody to the influenza A/Hong Kong/1/68 (H3N2) and the variant A/England/42/72 (H3N2) was carried out by two methods, haemagglutination-inhibition (HI) and single radial diffusion (SRD). A comparison of the sensitivity of the two tests indicated that the proportion of sera that produced a zone of 2.5 mm or larger in the SRD tests was equivalent to the proportion that gave HI titres of 1: 40 or more. The test was carried out on serum samples collected from various regions of England. The results showed that approximately 70% had antibody to the A/HK/1/68 virus and only 35% had antibody to A/England/42/72. The SRD test was shown to have several practical advantages for seroepidemiological studies.


Use of trace elements in intravenous hyperalimentation solutions.


Use of 8-anilino-1-naphthalenesulfonic acid in radioimmunoassay of triiodothyronine.


Uses of prolactin- and growth hormone-producing rat pituitary tumor cells in culture.


UDP-glucuronyltransferase activity towards oestriol in fresh and cultured foetal tissues from man and other species.


UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene.


Vaccination against Marek's disease: immunizing effect of purified turkey herpes virus and cellular membranes from infected cells.


Vesicoureteral reflux in the primate.

Vesicoureteral reflux in the primate.


Vertebrobasilar arterial insufficiency with dementia. Controlled trials of treatment with betahistine hydrochloride.


Viral hepatitis and autoimmune liver diseases.


Viral vaccines: various cell substrates and long-term prospective studies.


Von Willebrand's disease in Italy. A study of 13 families from a small area in the province of Vicenza.


31P-NMR studies of tRNA.

31P-NMR studies of tRNA.


5'-Nucleotidase and an acid phosphatase of spinal cord. Comparative histochemistry and specificity of the enzymes in mouse and cat spinal cords. Cytologic localization in mouse substantia gelatinosa.


Panel discussion: practical importance of generic equivalence.


'A matter of routine'; relationships between temporary disablement patterns of stress and type of care.


"The classification of viruses; why, when, and how".


A case of neurilemmoma in the mandible.

A case of neurilemmoma in the mandible.


A comparison of cortical functions in man and the other primates.


A double-blind crossover trial of disodium cromoglycate in asthmatic patients living under environmental control.


A fragment from the constant portion of IgG obtained by peptic digestion at high temperatures.


A fine structural study on the extracellular activity of alkaline phosphatase and its role in calcification.


A hazy ('bull's eye') plaque variant of bovine viral diarrhea virus.


A hominid mandible from East Rudolf, Kenya.


A method for alpha-L-iduronidase assay.

A method for alpha-L-iduronidase assay.


A new method for measuring the stress effects in minor oral surgery.


A precursor of the neck appendage protein of B. subtilis phage phi 29.


A pleiotropic mutation affecting expression of polar development events in Caulobacter crescentus. A developmental mutant of C. crescentus with altered polar surface structures has been isolated. The mutant lacks a flagellum and pili, and may have an abnormal DNA phage receptor site. A revertant regains the normal structures simultaneously. This point mutation allows normal flagellin synthesis, stalk formation, equatorial cell division, and rate of growth. The mutant phenotype indicates that the assembly of the polar surface structures is coordinately regulated and independent of mechanisms regulating cell polarity and division.


A pteridine adsorbent for affinity chromatography.


A quantitative method for analysing competition where individuals cannot be identified.


A rapid method for the separation of guinea pig IgGl and IgG2.


A note on the adjustment of rates.

A note on the adjustment of rates.


A rapid procedure for the radioimmunoassay of rat growth hormone.


A reinterpretation of research on aggression.


A sporulation medium for Bacillus anthracis.


A stochastic locomotor control model for the goldfish (Carassius auratus).


A study of the ultrastructure of human basophil leukocytes.


Abdominal wound infections and plastic wound guards.


Abortion and menstrual extraction for the ambulatory patient. Complications attending menstrual regulation, office suction and curettage abortion, and ambulatory hospital suction and curettage abortion are discussed and minimum criteria for outpatient abortion are sought.  Guidelines established by the American College of Obstetricians and Gynecologists for the performance of abortion are reiterated.  Uterine perforation, pelvic infections, hemorrhage, and incomplete evacuation are complications which should not exceed usual hospital rates when abortion is performed in an office.  The possibilities that dilatation of the cervix in abortion may result in an increased risk of future stillbirth deliveries and premature delivery, that secondary infertility can result from subclinical salpingitis or the development of  intrauterine synechia, and that an increased risk of ectopic pregnancy may result from abortion are long-term complications that must be considered.  Standards, preoperative procedures, equipment and operative technique, and postoperative procedures and considerations in menstrual regulation are presented.  The usual procedures for office and hospital suction curettage abortion are presented and discussed.


Absence of disulfide bridges between heavy and light chains in IgA from chicken bile.


Accumulation of tritiated thyrotropin releasing hormone in different organs, especially in the thyroid.


Activation by ferrous ions of an alpha-mannosidase in rat testis and liver.


Activity and sexual behavior of neurological mutants in Drosophila melanogaster.


Active avoidance and discrimination learning in rats with protein or calorie deficit and centrophenoxine or palmitoyl ethanolamide treatment in early postnatal life.


A salmonellosis outbreak in New York City attributed to a catering establishment.


A technique for standardizing the jet injector and Mantoux tuberculin skin tests.


Acute myeloblastic leukemia after cure of ovarian cancer.


Acute myeloproliferative disorder following long-term chlorambucil therapy.


Adreno-leukodystrophy (sex-linked Schilder's disease). A pathogenetic hypothesis based on ultrastructural lesions in adrenal cortex, peripheral nerve and testis. Striated adrenal cells in the zona reticularis and inner fasciculata apparently constitute the initial adrenolytic lesion in patients with adreno-leukodystrophy (ALD). Cytoplasmic ballooning and macrovacuolization develop after the striations, and probably represent exaggerated responses to adrenocorticotropin (ACTH). Intracytoplasmic lamellae and lamellar-lipid profiles, containing a free 3beta-hydroxysterol, are the ultrastructural correlates of the striations seen with the light microscope. The ultrastructural demonstration of intracytoplasmic lamellae and lamellar-lipid profiles in adrenal striated cells, testicular interstitial cells, Schwann cells and brain macrophages from patients with ALD provides further morphologic evidence for a systemic metabolic defect common to the nervous and endocrine systems. In our experience, adrenal biopsy has proven to be the most effective procedure for the diagnosis of adreno-leukodystrophy. An hypothesis proposing a membrane abnormality affecting its stability and turnover might explain the concomitant destruction of adrenal cortex and brain in these patients.


Albumin, immunoglobulin A and G concentrations in sputum during and after status asthmaticus.


Airborne infection.

Airborne infection.


Aldosterone secretion in infantile malnutrition.


Aldosterone-induced protein in toad urinary bladder. Simultaneous electrophysiological and biochemical experiments demonstrated a specific aldosterone-induced protein in paired urinary hemibladders isolated from the toad Bufo marinus. Whenever aldosterone stinlmulated short-circuit current, aldosterone specifically increased [(35)S] methionine incorporation into a low-molecular-weight protein (about 12,000). Comparative studies with dexamethasone and insulin and inhibitory studies with spironolactone and actinomycin D suggest mineralocorticoid specificity.


Allograft tolerance in the absence of circulating antibodies.


Alpha 1-antitrypsin in septic infections during infancy.


Alpha1 antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis. alpha(1) Antitrypsin deficiency is a significant factor in the pathogenesis of neonatal cholestasis and progressive juvenile cirrhosis. The diagnosis may be suggested by the liver biopsy appearances and confirmed by immunochemical analysis of the serum. Genetic counselling of affected families is of importance, as medical treatment is ineffective at the present time.


Alpha1-antitrypsin and its deficiency.

Alpha1-antitrypsin and its deficiency.


Alteration of antigenic components of rat parotid gland following denervation.


Alteration of nociception by stimulation of cerebellar structures in the monkey.


Alteration of epididymal function and its relation to maturation of spermatozoa. Alteration of epididymal function and its relation to maturation of spermatozoa was studied in 54 adult male albino rats.  Levels of free and bound sialic acid in the spermatozoa and luminal contents of the epididymis and vas deferens were determined.  A group of 10 received rabbit antiserum to ovine luteinizing hormone (LHAS) sc .2 ml/day for 5 days.  2 groups of 8 animals each received 2.5 mg cyproterone acetate twice daily for either 15 or 30 days.  16 animals served as intact controls and 12 animals served as castrate controls.  Epididymis and vas deferens sperm counts were not affected by LHAS for 5 days or by cyproterone acetate for 15 days; however, sperm counts were decreased in the corpus (p less than .02), cauda (p less than .05), epididymidis and vas deferens  (p less than .01) when rats were treated with cyproterone acetate for 30 days.  Castration resulted in a marked reduction in all regions within 5 days.  In the intact rats spermatozoa sialic acid decreased in the cauda epididymidis (p less than .01) and increased in the vas deferens (p less than .001).  Sialic acid concentration was similar in those treated with either LHAS or cyproterone acetate for 30 days.  Bound sialic acid in the epididymal fluid increased (p less than .02) to a maximum in the corpus and cauda and decreased in the vas deferens (p less than .05).  LHAS or cyproterone acetate caused a reduction in bound sialic acid in the fluid of the epididymis and vas deferens.


Alterations in circulating thyroid hormones and thyrotropin in hepatic cirrhosis: evidence for euthyroidism despite subnormal serum triiodothyronine.


Amino acid sequence studies of human IgA myeloma proteins.


An experimental study on the effect of local hemostatics on bone healing in rabbits.


An idiotypic cross-reaction between two streptococcal antibodies from an individual rabbit.


An immunochemical characterization of the phytochrome destruction reaction.


An improved method for liquid scintillation counting of 59Fe in ferrokinetic studies.


An in vitro system for studying the kinetics of interchain disulfide bond formation in immunoglobulin G.


An assessment of provider behavior in shared professional facilities.


An omega protein from Drosophila melanogaster.


An A-V shunt for long-term hyperalimentation in azotaemic patients.


Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids.


Analysis of mathematical models of the effect of pH on fermentation processes and their use for calculating optimal fermentation conditions.


Antagonism of prostaglandins induced uterine contraction by cyproheptadine hydrochloride.


Anti-histone KSAchicken antibody from guinea pig.


An inexpensive methodology for immunization surveys.


Antibacterial action of the essential oils of some Australian Myrtaceae with special references to the activity of chromatographic fractions of oil of Eucalyptus citriodora.


Antibiotics, antiseptics and tubercle bacilli.


Antibody activation of mutant human fructosediphosphate aldolase B in liver extracts of patients with hereditary fructose intolerance.


Antibody affinity. VI. Synthesis of bivalent lactosyl haptens and their interaction with anti-lactosyl antibodies.


Anticomplementary sera in cutaneous vasculitis.


Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures.


Antisera produced to purified extracellular pectolytic enzymes from Sclerotinia fructigena.


An investigation of Takahashi's antitubercle phosphatide kaolin agglutination test (KAT) in leprosy.


Application of the continuous maximum principle to fermentation processes.


Arteriovenous fistula for self-treatment of hemophilia.


Arterial lesions associated with neurofibromatosis.


Assay of rifampicin in serum.

Assay of rifampicin in serum. Two methods for the assay of rifampicin in serum are described. The first is a conventional plate diffusion method, measuring concentrations down to 0.02 mug/ml, and the second a chemical extraction followed by measurement of the inhibition of uptake of (14)C-uridine by Staphylococcus aureus, which estimates in the range of 0.02 to 0.001 mug/ml. The methods were used to measure serum concentrations in man following doses of about 1050 mg and 75 mg rifampicin.


Association of type II congenital dyserythropoietic anaemia and von Willebrand's disease.


Assembly and secretion of immunoglobulin A.


Autoconjugates in Tetrahymena.

Autoconjugates in Tetrahymena.


Autodilution of fungal spore suspensions for viable counting.


Automated determination of the IgG and IgM fractions of Rhesus antibodies.


Autonomous rDNA molecules containing single copies of the ribosomal RNA genes in the macronucleus of Tetrahymena pyriformis.


B cell-derived immunoglobulin on activated mouse T lymphocytes.


Background activity in single cells of monkey visual cortex during visual tracking.


Bacteremic Pseudomonas pneumonia.

Bacteremic Pseudomonas pneumonia.


Apparent changes in cancer mortality, 1968. A study of the effects of the introduction of the Eighth Revision International Classification of Diseases.


Bacteriological findings in perinatal pneumonia.


Baker's yeast cytidine deaminase: substrate and inhibitor specificity, and a hypothesis on metabolic and regulatory significance.


Beta-glucuronidase in the streptococcal groups B and D.


Bilateral recurrent pneumothoraces: a rare complication of miliary tuberculosis.


Biochemical changes in the artery wall during genesis and regression of atheromatous lesions.


Blood group investigations among the gypsy population of Hungary. I. Examination of ABO, MN and Rh blood groups.


Biphasic stimulo-inhibitory effect of flavonoids on cell proliferation in vitro.


Bovine adrenal medullary dopamine-beta-hydroxylase: studies on the structure.


Bronchial lymphoid tissue.

Bronchial lymphoid tissue.


Bursal and postbursal cells in chicken. Occurrence of postbursal cells in bone marrow, thymus and spleen.


Cannabis: review of behavioral effects in animals.


Capillaria hepatica: granuloma formation to eggs. II. Peripheral immunological responses.


Carbonic anhydrase isoenzyme B in erythrocytes of subjects with thyroid disorders.


Carbonic anhydrase isoenzymes in nine troops of Kenya baboons, Papio cynocephalus (Linnaeus 1766).


Carriage of potentially pathogenic bacteria in the hair.


Blood-group U antigen on Rhnull leukocytes.


Cause and identification of taste and odour compounds in water.


Cell growth cycle and expression of histocompatibility antigens on cultured human lymphoid cells.


Changes in metabolism of undamaged sections of myocardium following infarction.


Changes in the autoimmunologic reactivity of Wistar rats receiving Freund's complete adjuvant.


Characteristics of unit responses in superior colliculus of the Cebus monkey.


Characteristics of acid phosphatase in Porcellio laevis latreille (Porcellionidae, Isopoda).


Characterization of degradation products of the cell wall released during growth and sporulation of Bacillus megaterium.


Chemical and biological basis of adjuvants.


Chemical, serological and biological properties of a serotype-specific polysaccharide antigen in Leptospira.


Chitinase activity during Drosophila development.


Chromosome abnormalities in rabbit preimplantation blastocysts induced by superovulation.


Chronic membranous glomerulonephritis caused by hepatitis B antigen-antibody immune complexes.


Chronic liver disease and hepatitis-B antigen: a prospective study. A long-term follow-up of 45 patients with chronic hepatitis and 41 with cirrhosis is reported. Hepatitis-B antigen (HBAg) was present in 19 (42%) of the chronic hepatitis patients and in 20 (49%) of those with cirrhosis. The clinical course and biochemical and histological findings in the HBAg-positive and the HBAg-negative cases were similar, suggesting that HBAg-positive chronic liver disease is not a distinct clinical entity. The presence of antigen and autoantibodies was not found to be mutually exclusive. In HBAg-positive cases antigen tended to persist for months and years. When no irreversible lesions exist disappearance of the antigen may be a sign that the liver disease will resolve.


Cicatricial pemphigoid. Immunofluorescent studies.


Clinical and laboratory studies with tobramycin.


Clinical effects and uses of hypothalamic releasing and inhibiting factors.


Clinical manifestations of coxsackievirus infections in children.


Clonazepam in the treatment of epilepsy.


Coexistent respiratory allergy and cystic fibrosis.


Common parameters in genetic athymia and senescence.


Comparative structure, morphogenesis and biological characteristics of the respiratory syncytial (RS) virus and the pneumonia virus of mice (PVM).


Comparative value of various methods for the preparation of complement-fixing rubella antigen.


Comparative study of platelet aggregation in various species.


Comparison between determination of free thyroxine index and effective thyroxine ratio in human serum. Four thyroid function indices were determined in the sera of 181 patients: total thyroxine (T-4), the triiodothyronine resin uptake (T-3 B.C.-index), the free thyroxine (T-4) index, and the effective thyroxine ratio (E.T.R.).A statistically significant correlation between the free T-4 index and E.T.R. could be established though this correlation seemed to be worse than could be expected from the literature. Two sets of correlation coefficients were shown: one obtained with the ordinarily used Pearson or product-moment correlation and one with the Spearman rank correlation. Because the assumptions and requirements for the proper use of the product-moment correlation statistics, such as a normal distribution of both variables, are seldom met, expecially not if a selected number of controls and patients is used for the correlation, it is advisable to use some kind of rank correlation statistics instead.The advantages and disadvantages of the E.T.R. and free T-4 index determination are described.


Comparison of the lodoamino acid distribution in thyroglobulins obtained from various animal species.


Comparison of different methods for determination of glomerular filtration rate in renal disease.


Comparison of transportation media for the culturing of N. gonorrhoeae.


Consumer price differentials between generic and brand name prescriptions.


Contractile responses and 45Ca movements in monkey ileal smooth muscle.


Contribution to the study of the genesis and regulation of characteristic quantities of the quantitative ballistocardiogram.


Contributions to the optimal use of human blood. IV. Quantitative analysis of the immunoglobulin isolation.


Correlated responses of different scute genotypes to long-term selection for increased abdominal bristle number in Drosophila melanogaster.


Contributions to the optimal use of human blood. V. A method to increase the yield of anti-D immunoglobulin by processing Cohn's fraction III.


Corynebacterium parvum as a therapeutic antitumor agent in mice. I. Systemic effects from intravenous injection.


Corynebacterium parvum as a therapeutic antitumor agent in mice. II. Local injection.


Cross-reactivity of Neisseria gonorrhoeae and Neisseria meningitidis and the nature of antigens involved in the bactericidal reaction.


Cytophilic properties of IgA to human neutrophils.


Cytotoxic effects of imipramine on platelets.


Demonstration of acid-base phosphorylation in chromatophores in the presence of a K+ diffusion potential.


CCNU (NSC-79037): preclinical toxicologic evaluation of a single intravenous infusion in dogs and monkeys.


Descriptive studies of a psychiatric hospital population.


Detection and enumeration of salmonella and pseudomonas aeruginosa.


Development and use of meningococcal vaccines.


Determination of the light chain type of paraproteins, identification of heavy chain disease.


Determination of apoceruloplasmin by radioimmunoassay in nutritional copper deficiency, Menkes' kinky hair syndrome, Wilson's disease, and umbilical cord blood.


Developmental biochemistry of bovine foetal muscle. I. DNA, RNA, dry matter and total nitrogen.


Diabetic acidosis and abnormal chest roentgenogram.


Diagnosis of active tuberculosis in a university hospital. Active tuberculosis was diagnosed in 100 patients at Sunnybrook Medical Centre during the five-year period 1968-72. These cases were studied to find out if any delay had taken place in establishing the diagnosis and starting treatment. Delay was found most frequently when patients presented with atypical disease or when microbiological investigations were negative or misinterpreted. However, in nine patients with positive Ziehl-Neelsen smears the diagnosis was delayed more than one week. Usually such delays were caused by a failure to send specimens promptly for examination for acid-fast bacilli. Lack of communication between the laboratory and the clinician was found to be responsible for delays in starting treatment in several patients. It is essential that the clinician in a general hospital be alert to the possibility of tuberculosis and that there be close cooperation between the clinical staff and the diagnostic services.


Differences in the first progeny of Drosophila melanogaster strains in interspecific competition.


Differential protein clearance in benign and malignant diseases. Application of automated immunonephelometric assay.


Differential uptake of human beta-glucuronidase isoenzymes from spleen by deficient fibroblasts.


Diphtheria deaths in the United States, 1959-1970.


Distribution of human placental lactogen in the last half of normal and complicated pregnancies.


Distribution of IgA subclasses in sera and bone marrow plasma cells of 21 normal individuals.


Disulfide bridges of human immunoglobulins A1 and A2.


Distribution of repetitious sequences in chick nuclear DNA. By an improved method of hydroxylapatite chromatography, the reassociated sequences of chick nuclear DNA were isolated, and their base composition analysed. By increasing the amount of reassociation, the G + C content of the renatured sequences decreased progressively to reach a mean value corresponding to that of the total DNA. In order to study the distribution of the families, or group of families having different amount of reassociation, DNA was fractionated by CsC1 density gradient centrifugation. Fractions having different G + C content were obtained, and their reassociation rates analysed. At high C(o)t value of renaturation (C(o)t=50) the amount of reassociated sequences included in the high or in the low buoyant density DNA fractions was approximately the same, but their G + C content was as expected different. At lower C(o)t values of renaturation (between C(o)t of 0.2 and the C(o)t of 10), the results indicated an heterogeneity of the repeated sequences in the A + T rich DNA fractions, as compared to the G + C rich ones.


Double-blind crossover study of diphenylhydantoin in angina pectoris.


Double paraprotein aemias (IgMK plus IgGK and IgGK plus BJL).


Drosophila rhodopsin: photochemistry, extraction and differences in the norp AP12 phototransduction mutant.


Directories of ambulatory health care facilities.


Early diagnosis of tuberculous meningitis.


Dynamics of nucleic acids and total proteins in the thymus and the bursa of Fabricius of chickens, under the action of cortisol.


East coast fever: 60Co-irradiation of Theileria parva in its tick vector, Rhipicephalus appendiculatus.


East Coast fever: quantitative studies of Theileria parva in cattle.


Editorial: Insulin: rates and routes of delivery.


Editorial: Meningococcal infections.

Editorial: Meningococcal infections.


Editorial: Prolonged intravenous feeding.


Editorial: Synthetic defect in ganglioside metabolism.


Editorial: Therapy in genetic disease.

Editorial: Therapy in genetic disease.


Effect of antibody-complement on multiple vs. single compartment liposomes. Application of a fluorometric assay for following changes in liposomal permeability.


Effect of dissolved carbon dioxide on life activity of antibiotic-producing microorganisms.


Effect of formaldehyde, glutaraldehyde and sucrose on the tissue antigenicity.


Effect of light and temperature on the bleaching of the yellow mutant Y-1 of Euglena gracilis.


Effect of hypoglycemic sulfonylureas on hepatic fructose metabolism in the rat.


Effect of nitroglycerin on the mechanical and metabolic performance of the isolated aerobic and hypoxic rat heart.


Effect of nitroglycerine on the quantitative ballistocardiogram.


Effect of oxygen tension on the aldolases of Mycobacterium tuberculosis H37Rv.


Effect of penicillin irradiation on bacterial growth and penicillin resistance.


Effect of thyrocalcitonin on the blood calcium level and degree of adhesion of the hepatocytes.


Effect of viscosity on swimming velocity of bacteria. A theory is given for the swimming velocity of a flagellated bacterium and its variation with the viscosity of the surrounding fluid. The theory is shown to agree fairly well with the experimental observations of Schneider and Doetsch on Pseudomonas aeruginosa for viscosities greater than 2 centipoise. However, it fails to account for the decrease of velocity observed when the viscosity decreases from 2 to 1.1 centipoise.


Effect of vitamin A and protein-calorie undernutrition on immune responses.


Effect of L8027, a new potent inhibitor of prostaglandin biosynthesis, on the metabolism and response to glucagon of rat adipose tissue.


Effects of (-)delta 9-trans-tetrahydrocannabinol on social behavior of squirrel monkey dyads in a water competition situation.


Effects of a polychlorinated biphenyl mixture (aroclor 1254) and DDT on biliary thyroxine excretion in rats.


Effects of an oral enzyme preparation, Chymoral, upon serum proteins associated with injury (acute phase reactants) in man.


Effects of bacterial products on lymphocytes and macrophages: their possible role in natural resistance to listeria infetion in mice.


Effects of luteinizing hormone releasing hormone and thyrotrophin releasing hormone on rabbit adipose tissue.


Effects of positive pressure ventilation on intrarenal blood flow in infant primates.


Effects of proline and hydroxyproline on amino acid levels in Drosophila.


Effect of C-reactive protein, PHA, PWM and choline phosphate in 3H-thymidine uptake of leukocytes of leprosy patients and normal individuals.


Effects of stearic spin-labels on the photochemical activities of chromatophores from Rhodospirillum rubrum.


Effects of somatostatin on the secretion of thyrotropin and prolactin.


Effects of structural heterozygosity on the recovery of autosomal (II-3) translocations from x-irradiated mature and immature oocytes of Drosophila melanogaster.


Effects on the pituitary-thyroid axis and prolactin secretion of single and repetitive oral doses of thyrotropin-releasing hormone (TRH).


Electro-oculography.

Electro-oculography.


Electron microscopic appearance of dentin after decalcification and recalcification in vitro.


Electroradioimmunoassay (ERIA): a new type of double antibody radioimmunoassay based on electroimmunodiffusion.


Endoprostheses in the treatment of femoral neck fractures.


Enhancement of fat elimination during intravenous feeding.


Enhancement of immunogenicity of a BALB-c myeloma protein in BALB-c mice.


Environmental pollution, social costs, and health policy in the United States.


Epidemiological study on brucellosis of the Mongolian People's Republic.


Epizootiology of Minchinia nelsoni in susceptible wild oysters in Virginia, 1959 to 1971.


Equilibrium dialysis.

Equilibrium dialysis.


Epidemiology of selected sarcomas in children.


Erosions of the skull.

Erosions of the skull.


Erythroblastosis: the potential for eradication.


Ethylene oxide sterilization kinetics.

Ethylene oxide sterilization kinetics.


Essential L-amino acids for hyperalimentation in patients with disordered nitrogen metabolism.


Epidemiological problems in paediatric intensive therapy and resuscitation unit.


Evaluation and treatment of multiple myeloma and related disorders.


Evaluation of a quantitative platelet-collagen adhesiveness test system.


Evaluation of the bag--CO2-generating-tablet method for isolation of Neisseria gonorrhoeae.


Events surrounding the early development of Euglena chloroplasts: experiments with streptomycin in non-dividing cells.


Events surrounding the early development of Euglena chloroplasts: cellular origins of chloroplast enzymes in euglena.


Evidence for inducible, L-malate binding proteins in the membrane of Bacillus subtilis. Identification of presumptive components of the C4-dicarboxylate transport systems.


Evolution of the marked chromosomes of primates: experimental evidence for centric fusion.


Experimental catecholamine-induced chronic cerebral vasospasm. Myonecrosis in vessel wall.


Ethylenediaminetetraacetate-induced release of RNA and proteins associated with ultrastructural changes in Trichomonas vaginalis.


Experimental subacute sclerosing panencephalitis in the hamster. Ultrastructure of the chronic disease.


Experimental transmission of sarcocysts from cattle to mice.


Experimental tuberculosis in lechwe antelope in Zambia.


Explanation of a new CHA document: board, CEO, and medical staff relationships.


EEG and vigilance during the petit mal attack.


Facilitated diffusion of CO2 across albumin solutions. The steady-state CO(2) flux across thin layers of 30 g/100 ml albumin solutions was measured in two different CO(2) partial pressure ranges (boundary PCO(2) values 3 and 8 torr, and 160 and 650 torr, respectively). From the data the apparent diffusion coefficient for CO(2), DCO(2), was calculated. In the high PCO(2) range a value of DCO(2) was found which is to be expected on the basis of diffusion of dissolved CO(2) only. In the low PCO(2) range DCO(2) was about 100% higher than in the high PCO(2) range, when carbonic anhydrase was present and the pH was approximately 7.7. DCO(2) depended on the concentration of carbonic anhydrase. It increased with increasing pH. It is concluded that an additional diffusion of bound CO(2) (facilitated CO(2) diffusion) occurs in the low PCO(2) range and that this transport involves the hydration of CO(2). From the diffusion coefficients in the two PCO(2) ranges the rate of facilitated diffusion was determined. Approximate calculations show that this rate (at pH </= 7.7) can be explained on the basis of the proposed mechanism of facilitated CO(2) diffusion: bicarbonate diffusion and simultaneous proton transport by albumin diffusion. The view that facilitated CO(2) diffusion is mediated by the diffusion of albumin is supported by the experimental finding of a considerable suppression of the facilitated CO(2) flux in the presence of gelatinized agar-agar.


Evidence for heterogeneity of LW antigen revealed in a family study.


Falx "calcification"--does this exist?

Falx "calcification"--does this exist?


Evidence for C1 on human platelets.

Evidence for C1 on human platelets.


Fatty acid composition of monkey milk lipids.


Fertilization and development in vivo of rabbit oocytes cultivated in vitro.


Fibrinogen derivatives in a case of abruptio placentae.


Fibrinopeptides. 3. Synthesis of the protected nonapeptide sequence of fibrinopeptide-B of green monkey.


Fibrinolytic responses under alterations of acid-base balance and hypoxia.


Fish and shellfish hygiene. Report of a WHO Expert Committee convened in cooperation with FAO.


Fluorometric analysis of intermediates of the glycolytic and citric acid cycle pathway in human platelets.


Factors influencing variations in distribution of dental manpower in an urban area.


Food poisoning and salmonella infections in England and Wales, 1969-1972. An analysis of reports to the Public Health Laboratory Service.


Fractionation of staphylococcal enterotoxin A by isoelectric focusing.


Frequencies of streptococci of groups A, B, C, D, and G in urethra and cervix swab specimens from patients with suspected gonococcal infection.


Further studies on the biological properties of guinea-pig IgG1 antibodies: anti-lymphocyte antibodies.


Generalized hypersensitivity reaction and visceral arteritis with fatal outcome during glibenclamide therapy.


Genetic determination of tuberculin hypersensitivity in chicken inbred lines.


Genetic load in natural populations: is it compatible with the hypothesis that many polymorphisms are maintained by natural selection? Recent studies of genetically controlled enzyme variation lead to an estimation that at least 30 to 60% of the structural genes are polymorphic in natural populations of many vertebrate and invertebrate species. Some authors have argued that a substantial proportion of these polymorphisms cannot be maintained by natural selection because this would result in an unbearable genetic load. If many polymorphisms are maintained by heterotic natural selection, individuals with much greater than average proportion of homozygous loci should have very low fitness. We have measured in Drosophila melanogaster the fitness of flies homozygous for a complete chromosome relative to normal wild flies. A total of 37 chromosomes from a natural population have been tested using 92 experimental populations. The mean fitness of homozygous flies is 0.12 for second chromosomes, and 0.13 for third chromosomes. These estimates are compatible with the hypothesis that many (more than one thousand) loci are maintained by heterotic selection in natural populations of D. melanogaster.


Genetically expressed abnormalities in the fetus.


Glycoside cleavage reactions on erythromycin A. Preparation of erythronolide A.


Growth and active biomass production of Lactobacillus casei.


Growth of microorganisms during exponential phase.


GM3 (hematoside) sphingolipodystrophy.

GM3 (hematoside) sphingolipodystrophy.


Haemoproteus balearicae sp. nov., from crowned cranes, Balearica pavonina pavonina and B. pavonina gibbericeps.


Halothane hepatitis. Current concepts.

Halothane hepatitis. Current concepts.


Health aspects of environmental pollution control: planning and implementation of national programmes. Report of a WHO Expert Committee.


Heat-stable stimulating factor for fatty acid synthetase from Mycobacterium tuberculosis H37Rv.


Glutaraldehyde induced activation and polymerization of horse liver alcohol dehydrogenase.


Hemagglutinins and enzyme inhibitions: comparative studies on the reactivity of anti-A agglutinins of Helix pomatia and Euhadra callizona amaliae.


Hematogenous Streptococcus faecalis pyelonephritis in the rat. A histologic, immunopathologic and bacteriologic study. The demonstration of bacterial antigens in active pyelonephritis in man has been inconsistent. In this paper we have studied 110 rats with experimental pyelonephritis induced by a single intravenous injection of Streptococcus faecalis. The animals were studied at intervals up to 1 year; bacteremia, urine and renal parenchymal bacterial counts were monitored. In these animals it was observed that bacteriuria and positive bacterial cultures of renal tissue persisted up to 1 year in some rats. Bacteria and their antigenic products in small foci were detected by immunofluorescence in the pyelonephritic lesions. The highly focal distribution of the bacterial antigens in bacteriologically positive tissues of this model suggest the need for careful fixation technics, availability of large tissue specimens and careful control of immunologic factors. These specific requirements to detect bacterial antigens may preclude the practical study of human pyelonephritic kidneys.


Hepatitis associated (Australia) antigen in Hawaii.


Hepatitis B antigen and pathological changes in the liver.


Histamine, putrescine and benzylamine oxidation during subcutaneous tissue inflammation in guinea-pig.


Gonococcal arthritis. Clinical features correlated with blood, synovial fluid and genitourinary cultures.


Histochemical patterns of hemangioma in oral mucosa.


Histological studies on the ovaries of Egyptian buffaloes with special reference to the corpus luteum.


Hodgkin's disease terminating in acute myeloid leukaemia.


Hookworm enteropathy.

Hookworm enteropathy.


Human liver alpha-D-mannosidase activity.


Hormonal contraceptives and carbohydrate tolerance. II. Influence of medroxyprogesterone acetate and chronic oral contraceptives. Glucose tolerance in a group of women using injection of a depot progestogen (Depo Provera 150) for 7 months and in a group who had used various types of oral contraceptives (OCs) for at least 3 years were done to help understand the clinical  significance of the reported changes.  After 4 months of Depo Provera treatment there was no significant change in glucose or insulin levels from protreatment levels.  After 7 months, the mean basal glucose level was significantly higher than pretreatment (p.01).  OGTT glycemia levels were not significantly higher (p.01) than pretreatment and fasting serum triglycerioles were decreased.  Growth hormone levels were significantly lowered (p.01) from pretreatment levels.  In the group using oral contraceptives, early insulin levels after a glucose load were lower (p.01) in women treated with OCs than in controls.  Borderline abnormal mean glucose assimilation levels (K) were seen in 11 women of the 80 studied.  This was not significantly different from the control group.  The group using Neogynon showed the highest insulin levels of all subgroups.  It is suggested that the nortestosterone derivatives may play a role in the impairment of carbohydrate metabolism.


Human myeloma marrow cells in immunologically deficient mice. Intact human bone marrow cells from 7 patients with myelomatosis were inoculated intravenously into adolescent CBA mice rendered immunologically deficient by thymectomy followed by total body irradiation (600 rad). Each inoculum of human myeloma marrow cells and subsequent passages of intact mouse marrow and spleen cells resulted in the presence of morphological changes in the marrow, spleen and peripheral blood of a proportion of these mice which were closely similar to those seen in the human donor. A substantial amount of human immunoglobulin (IgG and IgA) was detected in the sera of some of the mice showing morphological changes. Mice prepared identically but remaining uninoculated or receiving intact human bone marrow cells from 3 patients with no evidence of haematological malignancy showed none of these changes when examined after similar intervals.There are at least 3 possible explanations for these findings: in mice receiving human myeloma marrow cells they might be accounted for by the persistence and replication of these cells in an immunologically deficient host. In mice receiving a first, second or third passage of abnormal mouse marrow and spleen cells they might similarly be accounted for by the survival and multiplication of a stem cell secreting both mouse and human immunoglobulins. Alternatively, the mouse stem cells may in some way have been transformed following infection by a transmissible agent originally present in the myeloma donor marrow cells.


Hybrid alpha-amylases produced by transformants of Bacillus subtilis. I. Purification and characterization of extracellular alpha-amylases produced by the parental strains and transformants.


Hybrid alpha-amylases produced by transformants of Bacillus subtilis. II. Immunological and chemical properties of alpha-amylases produced by the parental strains and the transformants.


Hyperalimentation at home.

Hyperalimentation at home.


Hyperalimentation in the management of gastro-intestinal-cutaneous fistulae.


Hypobilirubinemia in patients with polychlorinated biphenyls poisoning.


Hypothalamic hypopituitarism in an adolescent girl: assessment by a direct functional test of the adenohypophysis.


Hypothalamic releasing substances and inhibitors.


HL-A phenotypes, immunoglobulins and K and L chains in multiple myeloma.


Hypothalamus as an endocrine organ--I.

Hypothalamus as an endocrine organ--I.


HMO--friend or foe?

HMO--friend or foe?


Hydrolysis and synthesis of aortic cholesterol esters in atherosclerotic baboons. Effect of polyunsaturated phosphatidyl choline on enzyme activities.


Identification of D-erythro-dihydroneopterin triphosphate, the first product of pteridine biosynthesis in Comamonas sp. (ATCC 11299a).


IgA and IgM immunoglobulin levels in chronic bronchitis of the child.


IgG anti-Lea.

IgG anti-Lea.


Immunization against bovine besnoitiosis with a live vaccine prepared from a blue wildebeest strain of Besnoitia besnoiti grown in cell cultures. 1. Studies on rabbits.


Immunization of rabbits against FSH and effects on the zona pellucida.


Immunochemical classification of nonisolated light chains of immunoglobulins.


Immunochemical nature of schistosomal antigens in the induction of delayed hypersensitivity.


Immunochemical investigations of bromelin fragments of normal human IgG.


Immunochemical studies on dextrans. 8. Specificity and cross-reactivity with dextrans of the antibodies formed in rabbits to isomaltohexaonic acid coupled to bovine serum albumin.


Immunoferitin analysis of membrane antigen density: A. Young and old human blood cells B. Developing erythroid cells and extruded erythroid nuclei.


Immunoglobulin classes in the hen's egg: their segregation in yolk and white.


Immunoglobulin levels in sera of patients with parasitic infections.


Immunoglobulins in the airway washings and bile secretions of chickens.


Immunohaematological aspects of modern prenatal, maternal and newborn care.


Immunological evidence for the existence of two kinds of L2 components in myosin light chains.


Immunological rebound after cessation of long-term chemotherapy in acute lymphocytic leukaemia: changes in distribution of T and B cell populations in bone marrow and peripheral blood.


In vivo stimulation of prolactin secretion in the rat by thyrotropin releasing factor, related peptides and hypothalamic extracts.


Increased cellular immunity against host cell antigens induced by vacciniavirus.


Induction of minute mutations in Drosophila melanogaster by calf thymus DNA.


Influence of change of body position on arterial oxygenation and acid-base status in the horse in lateral recumbency, anaesthetized with halothane and efficiency of postanaesthetic oxygen administration.


Influence of early social environment on behaviour of the protein-calorie malnourished rats.


Influence of osmotic pressure on transformable and non transformable variants of Neisseria meningitidis. 1. Survival and turbidity changes.


Influence of the redox potential of the medium on the activity of polyphenol oxidase.


Immunosuppression by Junin virus. Ultrastructural study.


Inhibition of mammalian dihydrofolate reductase by selected 2,4-diaminiquinazolines and related compounds.


Inhibition of tyrosinase-catalyzed melanin formation by catechol phenyl sulfones.


Interaction between C1q, C1r and C1s from human serum.


Interaction of thyrotropin-releasing hormone and dopamine on the release of prolactin from the rat anterior pituitary in vitro.


Interaction of concanavalin A with model substrates.


Incidence of vasectomies refused and reasons for refusal. Survey of clinics and physicians.


Internal regulation of physiological processes through local venoarterial pathways: a review.


Intracellular ribonuclease activity in stationary phase cells of Bacillus subtilis.


Intractable malabsorption with a flat jejunal mucosa and selective IgA deficiency. A case report with immunological and autoradiographic studies.


Investigation of the diuretic effect of glibenclamide in healthy subjects and in patients with pituitary and nephrogenic diabetes insipidus.


Intramolecular fatty acid distribution in milk fat triglycerides of monkeys.


Isolation and characteristics of a ureolytic strain of Selenomonas ruminatium.


Isolation and identification by sequence analysis of experimentally induced guinea pig amyloid fibrils. Amyloidosis was produced experimentally in guinea pigs by multiple casein injections. Amyloid fibrils were isolated and fractionated and a protein obtained that had an amino acid composition comparable with A protein, a unique nonimmunoglobulin constituent of secondary amyloid deposits. N-terminal sequence analysis demonstrated a sequence homologous with that of A proteins from human and monkey preparations but preceded by a 5-residue peptide which had an N-terminal histidine. A definite species specificity in A protein from human and guinea pig was identified on immunologic analysis.


Isolation and purification of human serum alpha-1 acid glycoprotein.


Isolation and partial characterization of carbonic anhydrase from erythrocytes of Meleagris gallopavo.


Isolation of bovine adenovirus type 1 in the Sudan.


Isolation of desialylated and low-iodinated thyroglobulin in an experimental rat thyroid tumour.


Isolation of human serum alpha-2 HS glycoprotein.


Isolation of messenger ribonucleoproteins from mammalian cells.


Isolation, properties, and structure of human IgA myeloma globulins.


Isolectins of Phaseolus vulgaris. A comprehensive study of fractionation.


Kinetic model of secondary metabolite production and its use in computation of optimal conditions.


Juvenile xanthogranuloma of the oral cavity. An electron microscopic study.


Lactate dehydrogenase isozymes of the Mongolian gerbil, Meriones unguiculatus. 3. Immunochemical studies on the nature of testicular LDH-X.


Lectins from Abrus precatorius and Ricinus communis. I. Immunochemical relationships between toxins and agglutinins.


Kinetics of RNA labeling in toad bladder epithelium: effects of aldosterone and related steroids. Sucrose gradient analysis revealed an aldosterone-dependent increase in the incorporation of [(3)H]uridine into a nonmethylated, rapidly labeled RNA that sedimented at 9-12 S. This effect was antagonized by an anti-mineralocorticoid, spironolactone (SC 9420), and was not elicited either by a glucocorticoid, cortisol, or by the inactive isomer, 17-alpha-isoaldosterone. These findings are in accord with the inference that mRNA is induced by aldosterone during the latent period and that the induced mRNA mediates the action on sodium transport.


Letter: Demeclocycline hydrochloride and diminished sex drive.


Letter: Diabetic ketoacidosis.

Letter: Diabetic ketoacidosis.


Letter: Formation of 235-nanometer absorbing substance during glutaraldehyde fixation.


Letter: Non-comatose "diabetic coma".

Letter: Non-comatose "diabetic coma".


Letter: Hyperglycemia and sickness.

Letter: Hyperglycemia and sickness.


Letter: Polymerization of glutaraldehyde at fixative pH.


Letter: Prazosin in patients with chronic renal failure.


Letter: Question raised regarding diagnosis of Hunter syndrome.


Letter: Side effect of tranylcypromine.

Letter: Side effect of tranylcypromine.


Letter: Rubella-specific IgM and a new inhibitor.


Letter: Standardization of the E.S.R.

Letter: Standardization of the E.S.R.


Letter: The growth of Neisseria lactamica on media selective for pathogenic Neissericaeae.


Letter: Treatment of status epilepticus with sodium valproate.


Letter: Urethral burning as a side effect of cromolyn sodium.


Letter: Tuberculous polyradiculitis.

Letter: Tuberculous polyradiculitis.


Letter: Venoarterial difference in alpha1-antitrypsin levels.


Lung mechanics in antigen-induced asthma.


Lipoprotein lipase: properties of the enzyme isolated from post-heparin plasma.


Lyophilization, vacuum drying, and subsequent storage of Nosema pyrausta spores.


Management of angina pectoris. Therapeutic methods and physiologic mechanisms.


Management of the urethral diverticulum in women: a modified operative technique.


Mechanism of immunoglobulin polymer assembly.


Marasmus and Pneumocystis carinii pneumonia in institutionalised infants. Observations during an endemic.


Mechanism of inhibition of Bacillus subtilis DNA polymerase 3 by the arylhydrazinopyrimidine antimicrobial agents. Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of the nuclease similarly proceeds through formation of the ternary complex. The ternary complex was isolated by agarose chromatography. Like inhibition of the nuclease, optimum formation of the complex requires duplex DNA with single-stranded regions such as bacteriophage lambda DNA (purely single- and double-stranded DNA are ineffective) and is antagonized by specific deoxyribonucleoside triphosphates. Formation of the ternary complex requires a di- or polyvalent cation and is inhibited by sulfhydryl reagents and high ionic strength. The complex dissociates with a half-life of the order of minutes at 4 degrees .


Mechanistic studies of the reduction of Rhus vernicifera laccase by hydroquinone.


Membrane immunoglobulin in acute lymphocytic leukaemia cells.


Leucocyte migration inhibition by antisera to immunoglobulin chains and fragments.


Meningococcal meningitis: an atypical case. A case of meningococcal meningitis is described in a patient who had not received antibiotics before admission. Three lumbar punctures were performed over a seven-day period, but only the cerebrospinal fluid from the third yielded a positive culture. The importance of repeated lumbar punctures in patients with undiagnosed meningitis is emphasized.


Mesoionic purinone analogs. 7. In vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo(3,2-a)pyrimidine-5,7-diones.


Metabolism of palmotoxins B0 and G0 in vitro.


Method for the production of clinically applicable human immunoglobulin preparation with high IgA content.


Measurement of vibration of the basilar membrane in the squirrel monkey.


Methods used for the analysis of proteins in the urine.


Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.


Microbial glucosidation of dihydroxyanthraquinones. General properties of the glucosidation system.


Microbiologic assay of erythrocytic folate content by the aseptic addition method.


Microbiological changes in the uneviscerated bird hung at 10 degrees C with particular reference to the pheasant.


Misconception about chelation.

Misconception about chelation.


Model experiments for peptide fragment coupling without racemization-prone activated amino acid derivatives.


Modifying effect of cysteine on the induction of chromosomal aberrations by thioTEP in a culture of human leukocytes.


Molecular events of immune response.

Molecular events of immune response.


Monospecific serum for typing Haemophilus influenzae type b produced by immunization with Escherichia coli strain 'Easter'.


Mouse bone marrow lymphocytes and their differentiation.


Multiple systemic and ocular malformations associated with maternal LSD usage.


Mutants of Bacillus subtilis with altered capacity to be donors of DNA in spontaneous transformation. Communication II. Some properties of the mutants.


New type of delayed light emission from photosynthetic bacteria.


New, improved thin layer chromatography for polychlorinated biphenyls, toxaphene, and chlordane components.


Newer aminoglycosides--amikacin and tobramycin: an in-vitro comparison with kanamycin and gentamicin. Tobramycin and amikacin are new aminoglycoside antibiotics which resemble gentamicin and kanamycin respectively in pharmacokinetic, toxicological, and some microbiological respects. Minimum inhibitory concentrations for these four antibiotics have been determined against 393 bacterial strains (13 species from eight genera) isolated from clinical materialKanamycin was the least active, 89% of the Pseudomonas aeruginosa strains being resistant. Resistance was also found in 21% of the Klebsiella aerogenes, 16% of the indoleproducing Proteus species, 4% of the E. coli and 3% of the Enterobacter spp. tested. Providenca stuartii strains were often resistant to gentamicin and tobramycin.Apart from these exceptions, however, all the organisms tested were sensitive to all four compounds, gentamicin and tobramycin usually showing the highest intrinsic activity.Amikacin was the most active compound against a selection of strains chosen because of their resistance to one or more of the aminoglycosides. Thus, amikacin represents a significant advance over kanamycin and seems to be superior to gentamicin in terms of its in-vitro properties. This is especially the case in those unusual circumstances when gentamicin-resistant strains are a problem. We suggest that amikacin warrants further investigation since it may prove to be a valuable alternative to gentamicin in the treatment of life-threatening infections.


Nonequilibrium thermodynamic analysis of the coupling between active sodium transport and oxygen consumption. Sodium transport and oxygen consumption have been simultaneously studied in the short-circuited toad skin. A constant stoichiometric ratio was observed in each skin under control condition (NaCl-Ringer's solution bathing both sides of the skin) and after block of sodium transport by ouabain. During alterations of sodium transport by removal and addition of K to the internal solution the stoichiometric ratio is constant although having a value higher than that observed in other untreated skins. The coupling between active sodium transport and oxygen consumption was studied after a theoretical nonequilibrium thermodynamic model. Studies were made of the influence of Na chemical potential difference across the skin on the rates of Na transport and oxygen consumption. A linear relationship was observed between the rates of Na transport and oxygen consumption and the Na chemical potential difference. Assuming the Onsager relationship to be valid, the three phenomenological coefficients which describe the system were evaluated. Transient increases in the rate of sodium transport and oxygen consumption were observed after a transitory block of sodium transport by removal of Na from the external solution. Cyanide blocks completely the rate of oxygen consumption in less than 2 min and the short-circuit current measured after that time decays exponentially with time, suggesting a depletion of ATP from a single compartment.


Norepinephrine metabolism in the rat brain following acute and chronic administration of thyrotropin releasing hormone.


Nucleotide sequence of Bacillus megaterium 5 S RNA.


Nutritional requirements of adult Drosophila melanogaster: the influence of the casein concentration on the duration of life.


Navajo infant mortality, 1970.

Navajo infant mortality, 1970.


Observations of uridine diphosphate glucuronyltransferase activity towards oestriol and xenobiotics in developing and cultured tissues from mouse and man.


National resource requirements for abortion services.


Observations on the ultrastructure of platelets in Glanzmann's disease.


Occlusion of the posterior ciliary artery. 3. Effects on the optic nerve head.


Occlusion of the posterior ciliary artery. I. Effects on choroidal circulation.


Ocular findings associated with ring B chromosome.


On ethology and human behaviour.

On ethology and human behaviour.


On 14C-nicotine distribution and movements in slices from monkey cerebral cortex.


Optical radiation and Zeiss short-pulsed xenon photocoagulators. I. Clinical considerations of articulation with the Fankhauser slit-lamp delivery system.


Optokinetic nystagmus.

Optokinetic nystagmus.


Oral amoxicillin in acute uncomplicated gonorrhea. Of 53 patients with acute uncomplicated gonorrhea treated with amoxicillin 2 g and probenecid 1 g orally as a single administration, six failed to return for follow-up examination, 10 developed postgonococcal urethritis and one was a treatment failure. The remainder achieved symptomatic cure in an average of 2.3 days. Adverse drug effects were infrequent, mild and transient. We conclude that this dose of amoxicillin and probenecid is a safe and effective treatment regimen.


On aging, dying, and denying. Delivering care to older dying patients.


Oxygen consumption and sodium transport in the toad urinary bladder.


Outpatient intravenous medications in the management of cystic fibrosis.


Pancreatic ribonuclease: enzymic and physiological properties of a cross-linked dimer. Monomeric ribonuclease A has very low activity toward typically double-stranded RNA's; the dimeric form of ribonuclease A obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate . polyuridylate and 440 times the activity of the monomer toward the double-stranded RNA of a virus from Penicillium chrysogenum. The half-life of the dimer in the bloodstream of the rat is 12 times that of the mononmer.


Paronychia caused by HB-1 organisms.

Paronychia caused by HB-1 organisms.


Ophthalmic preservatives and vehicles.

Ophthalmic preservatives and vehicles.


Partial amino acid sequences of variable regions of a human IgG1 (kappa) myeloma protein with anti-rubella activity.


Pathology of acute poisoning with the insecticide Sevin in the bent-nosed clam, Macoma nasuta.


Partial purification and some properties of tobacco etch virus induced intranuclear inclusions.


Peptides from the dinitrophenyl binding site of myeloma IgA of mouse MOPC 315.


Perinatal care in British Columbia: Diagnosis and management of hemolytic disease of the newborn. We undertook to measure standards of perinatal care in British Columbia by studying the management of hemolytic disease of the newborn as the sample situation.Our data show that many isoimmunized pregnant women are delivered in hospitals that have infrequent experience with this problem, and by physicians who have little experience with this disease.The physician referral pattern, in regard to maternal isoimmunization, indicated that the more severely affected patients were managed by specialists, particularly those attached to teaching hospitals. However, 25% of the infants treated by exchange transfusion were managed by nonspecialists in nonteaching hospitals.Hospital record search, used as a method of medical audit and as a source of data for comparison with physician reports, did not result in dependable or complete information. Rates of disagreement between items from two data sources, physician report and hospital record, were frequently very high. Our experience suggests that comparison of these two data sources is not an ideal method of assessment of quality of care.A smaller caseload of isoimmunized pregnant women will result from the present prevention program. Nevertheless, cases will continue to occur. Our work supports the conclusion that a program of continuing education covering the diagnosis and management of hemolytic disease of the newborn is still necessary.


Pharmacological studies on cephacetrile in human volunteers.


Pharmacology of uricosuric drugs.

Pharmacology of uricosuric drugs.


Pheromonal control of mating patterns in Drosophila melanogaster.


Phoratoxin, a toxic protein from the mistletoe Phoradendron tomentosum subsp. macrophyllum (Loranthaceae). Immunological properties and tests for proteinase inhibiting and antibiotic effects.


Physical-chemical characteristics of J chains obtained from IgM.


Plasma triglyceride metabolism in rabbits injected with tetrachlorobiphenyls.


Platelet function and coagulation profile in lupus erythematosus. Studies in 50 patients.


Pleuropulmonary manifestations of Waldenstrom's macroglobulinemia.


Possible control mechanisms in tetracycline production: a kinetic model.


Pet ownership in a suburban-rural area of California, 1970.


Precipitin cross-reactions between human and animal J-chains.


Preclinical toxicologic evaluation of tetrahydrouridine (NSC-112907) in beagle dogs and rhesus monkeys.


Preclinical toxicologic evaluation of 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl),-dihydrochloride (NSC-135758) in dogs and monkeys.


Preclinical toxicology of alpha-2'-deoxythioguanosine (NSC-71851).


Preclinical toxicology studies with ICRF-159 (NSC-129943)--a new antineoplastic drug.


Preparation and properties of a conjugate containing dextranase and concanavalin A.


Preparation, gas chromatographic behavior, and spectroscopic properties of hydroxylated chlorobiphenyls.


Prevention of folate deficiency by food fortification. V. A pilot field trial of folic acid-fortified maize meal.


Primary drug-resistant Mycobacterium tuberculosis isolated in Massachusetts in 1972.


Primitive immunoglobulins and other proteins with binding functions in the shark.


Primary isoniazid-resistant tuberculosis in children. Clinical features, strain resistance, treatment, and outcome in 26 children treated at Kings County Medical Center of Brooklyn between the years 1961 and 1972.


Proceedings: Abnormalities in rheumatoid synovial collagen: studies on synovial polymeric collagens (PC) from normal individuals and patients with rheumatoid and other arthropathies.


Proceedings: Ante-natal plasmapheresis in severe rhesus iso-immunization.


Proceedings: Influence of tubercle aggregate size on the severity of adjuvant arthritis in the rat.


Proceedings: Joint involvement in spondylo-epiphyseal dysplasias.


Progress of competence development in Bacillus subtilis.


Prolactin release in the sheep.

Prolactin release in the sheep.


Problems, personnel, and proficiency of small hospital laboratories.


Properties of mouse leukemia viruses. VII. The major viral glycoprotein of friend leukemia virus. Isolation and physicochemical properties.


Properties of the principal liver target protein of a hepatic carcinogen.


Propranolol in the management of hypertension in a long-term dialysis program.


Protective effect of different lining materials placed under composite resin restorations in monkeys.


Protein-calorie malnutrition in young miniature swine: brain free amino acids.


Protein-calorie malnutrition in young miniature swine: serum free amino acids.


Proteins S14 and S19 are near-neighbors in the E. coli ribosome.


Pseudo-Hurler polydystrophy (mucolipidosis 3). A clinical, biochemical and ultrastructural study.


Pseudo-Chediak-Higashi anomaly in acute leukemia. A significant morphologic corollary?


Pseudomonas aeruginosa infection in cystic fibrosis. Distribution of B and T lymphocytes in relation to the humoral immune response.


Pseudomonas aeruginosa infection in cystic fibrosis. Relationship between mucoid strains of Pseudomonas aeruginosa and the humoral immune response.


Pulpal response to phosphoric acid.

Pulpal response to phosphoric acid.


Purification and properties of glycogen phosphorylase a from the muscle of the blue crab, Callinectes danae.


Purification and properties of 3-aminopropanal dehydrogenase from a Pseudomonas species.


Purification and properties of L-asparaginase from Serratia marcescens.


Purification by ionic precipitation of the first component of human complement and complement esterase.


Purine metabolism in Neisseria meningitidis. 1. Utilization of exogenous adenine.


Quantitative haemadsorption assay of measles and parotitis virus in the presence of each other.


Quinazolines as inhibitors of dihydrofolate reductase. 2.


Quantitative role of base exchange in phosphatidylethanolamine synthesis in isolated rat hepatocytes.


Radio-isotopic assessment of phytohaemagglutinin-stimulated lymphocytes from patients with protein calorie malnutrition.


Radioimmunoassay for serum triiodothyronine: evaluation of simple techniques to control interference from binding proteins.


Radioimmunoassay of serum triiodothyronine on small, reusable, Sephadex columns.


Radioimmunoassay of thyrotrophin releasing hormone (TRH).


Radioimmunoassays for adriamycin and daunomycin.


Radioimmunologic measurements of naturally occurring antibodies. 3. Antibodies reactive with Escherichia coli of Bacteroides fragilis in breast fluids and sera of mothers and newborn infants.


Radiosensitivity to gamma rays of spores of a DNA polymerase deficient mutant of Bacillus subtilis.


Radiotherapy of carcinoma of the cervix.


Rate of thrombin-fibrinogen reaction in some mammalian species.


Rates of RNA synthesis during early embryogenesis in Drosophila melanogaster.


Re-evaluation of EDTA-chelated biuret reagent.


Reasons for the redox potential in microbial cultures.


Recent advances in ophthalmic genetics. Genetic counselling.


Receptive fields in single cells of monkey visual cortex during visual tracking.


Recovery of hepatitis B antibody from human plasma products separated by a modified Cohn fractionation.


Relation between the induction of hydroxylation and of glucuronidation in chick liver.


Relationship between survival, photoproduct production and repair capacity in a variant of Bacillus cereus.


Relationships between coenzyme Q and vitamin E.


Respiratory dilution effect in Bufo arenarum spermatozoa.


Respiratory disease profile in 22 patients with alpha 1-antitrypsin deficiencies.


Results of synovectomy of the knee in haemophilia.


Retention of cadmium in mice studied by whole body autoradiography.


Retropharyngeal abscess as the presenting feature of tuberculosis of the cervical spine.


Ribulose diphosphate oxygenase. V. Presence in ribulose diphosphate carboxylase from Rhodospirillum rubrum.


Rocket immunoselection for detection of heavy-chain diseases.


RH immunization in spontaneous abortion.


Salivary immunoglobulin A and albumin: values in children presenting with atypical mycobacterial lymphadenitis compared with normal controls.


Scanning electron microscopy of the human, guinea-pig and rhesus monkey seminal coagulum.


Red cell D antigen sites and titration scores in a family with weak and normal Du phenotypes inherited from a homozygous Du mother.


Secondary antibody deficiency syndrome in haemoblastosis.


Secretory and serum IgA in children with protein-calorie malnutrition.


Selective impairment of cell antigenicity by fixation.


Separation of hepatitis-associated antigen (HAA) from human plasma for the production of rabbit anti-HAA.


Sequence of meiotic events in female Drosophila melanogaster. Temperature-sensitive periods of autosomal crossing-over and secondary nondisjunction of X chromosomes.


Seroepidemiology and chemoprophylaxis disease due to sulfonamide-resistant Neisseria meningitidis in a civillian population.


Serologic diagnosis of mycoplasma infections by passive hemagglutination using sheep red blood cells sensitized by glutaraldehyde.


Serotyping of group B streptococci by slide agglutination fluorescence microscopy, and microimmunodiffusion.


Serum glutamic oxalacetic transaminase and serum glutamic pyruvic transaminase levels in buffalo-calves with enteric diseases.


Selected reminiscences of the Giza Memorial Ophthalmic Institute (Cairo).


Severe ABO haemolytic disease due to high titre IgG anti-B in an A2 mother.


Short term routine antibiotic prophylaxis in surgery.


Sleep in the armadillo Dasypus novemcinctus at moderate and low ambient temperatures.


Simultaneous assay by mass fragmentography of vanillyl mandelic acid, homovanillic acid, and 3-methoxy-4-hydroxy-phenethylene glycol in cerebrospinal fluid and urine.


Smoking behaviour: motivational determinants and modification techniques. A review.


Some aspects of childhood malnutrition as a public health problem.


Some general characteristics of the organization of the genome and the phenotypic expression of mutations in Drosophila.


Some motes on the concept of cross-reactivity.


Some immunologic considerations in focal scleroderma and progressive systemic sclerosis in children.


Some potential economic benefits of eliminating mortality attributed to schistosomiasis in Zanzibar.


Some properties of Staphylococcus aureus alpha and delta lysins.


Some quantitative and qualitative aspects of the stomach microflora of the conventional rat and hamster.


Specificity of antibodies: primary structural basis of hapten binding. The primiary structure of the 83 residues of the NH(2)-terminus of the V(II), region was determined for each of three different antibodies to hapten which were produced in inbred guinea pigs. Each antibody had a different and distinctive primary structure within each of the two "hypervariable" regions (Hv1 and Hv2) included in the analyzed part of the variable region of the heavy chain. The sequences of Hvl and Hv2 in the three antibodies were either unique or of restricted variability compared with those of "normnal" immunoglobulin G2. Further implication of Hv1 and Hv2 in contributing to ligand-binding specificity of antibodies came from the placement of residues modified by affinity labeling reagents in these hypervariable regions.


Spherulin as a complement-fixing antigen in human coccidioidomycosis.


Spontaneous (pathologic) rupture of spleen in malignancies.


Stepping movements of the forelimbs and the Schiff--Sherrington phenomenon.


Stereotactic operations in generalized forms of epilepsy.


Sterotactic hypothalamotomy in erethic children.


Some factors affecting staff attitudes toward offering intrauterine devices to adolescent patients.


Streptococcal infections in children. Comparison of the therapeutic effectiveness of erythromycin administered twice daily with erythromycin, penicillin phenoxymethyl, and clindamycin administered three times daily.


Structural studies on a human IgA1 myeloma protein with a carboxy terminal deletion.


Structure and function of the endocrine cell types of the islets.


Structure of wet specimens in electron microscopy. Improved environmental chambers make it possible to examine wet specimens easily. Several recent technological advances have increased the practicality and usefulness of the technique of electron microscopy of wet objects. (i) There have been gains in the effective penetration of high-voltage microscopes, scanning transmission microscopes, and high-voltage scanning microscopes. The extra effective penetration gives more scope for obtaining good images through film windows, gas, and liquid layers. (ii) Improved methods of obtaining contrast are available (especially dark field and inelastic filtering) that often make it possible to obtain sufficient contrast with wet unstained objects. (iii) Improved environmental chamber design makes it possible to insert and examine wet specimens as easily as dry specimens. The ultimate achievable resolution for wet objects in an environmental chamber will gradually become clear experimentally. Resolution is mainly a function of gas path, liquid and wet specimen thickness, specimen stage stability, acceleration voltage, and image mode (fixed or scanning beam) (13). Much depends on the development of the technique for controlling the thickness of extraneous water film around wet objects or the technique for depositing wet objects onto dry, hydrophobic support films. Although some loss of resolution due to water or gas scattering will always occur, an effective gain is anticipated in preserving the shape of individual molecules and preventing the partial collapse that usually occurs on drying or negative staining. The most basic question for biological electron microscopy is probably whether any living functions of cells can be observed so that the capabilities of the phase contrast and interference light microscopes can be extended. Investigators are now rapidly approaching a final answer to this question. The two limiting factors are (i) maintaining cell motility in spread cells immersed in thin layers of media and (ii) reducing beam radiation damage to an acceptable level. The use of sensitive emulsions and image intensifiers can bring the observation dose below that required to stop cell motility. Use of a timed, pulsed deflector system enables sufficiently short exposures to be obtained to eliminate blurring due to Brownian motion. Environmental chambers have enhanced the possibilities of electron diffraction analysis of minute crystals and ordered biological structures. High-resolution electron diffraction patterns (especially kinematic) of protein crystals can only be obtained in a wet environment. Hence, it may now be possible to obtain undistorted images of protein molecules. Moreover, by subjecting diffraction patterns to image-iterative techniques (56), it will be possible to phase the electron diffraction patterns to give a calculated image with a higher resolution than that which can be produced by electron microscope objective lenses. Environmental chambers offer exciting prospects for the determination of water structure and water and ice nucleation (atmospheric science). Nucleation data near the molecular level have been badly needed for some time. The application of environmental chambers in industrial chemistry, for example, in studies of polymerization, catalysis, and corrosion, are awaiting exploration. They offer an unusual approach to measurements of reaction kinetics through images that should be both sensitive and rapid.


Studies of complement complex C5b,6 eluted from--EAC-6: reaction of C5b,6 with EAC4b,3b and evidence on the role of C2a and C3b in the activation of C5.


Studies on neutral red-induced hypocalcaemia.


Study of genetic markers in bronchial asthma and diabetes mellitus.


Study of transitional stages in continuous culture of microorganisms.


Subacute sclerosing panencephalitis (SSPE) agent in hamsters. 3. Induction of defective measles infection in hamster brain.


Subconvulsive epileptiform discharge and behavioral impairment.


Subsite affinities of bacterial liquefying alpha-amylase evaluated from the rate parameters of linear substrates.


Surface and intracellular markers of mouse mesenteric and peripheral lymph node and Peyer's patch cells.


Synthesis and biological properties of 6'-amino-6'-deoxygentamicin A.


Synthesis of human connecting peptide derivatives and their immunological properties.


Systemic approach to the detection of explosive residues. 3. Commercial dynamite.


Studies on antiseptic soap.

Studies on antiseptic soap.


Systemic mastocytosis: control of lifelong diarrhea by ingested disodium cromoglycate. A 16-year-old boy with systemic mastocytosis from birth had a lifelong history of pronounced diarrhea. Treatment with ingested disodium cromoglycate (DSCG) restored a normal bowel movement pattern and this has been maintained for the six months he has been on treatment. Changes in dosage have repeatedly demonstrated a close relationship between the dose of ingested DSCG and the control of the diarrhea. This case report indicates the potential efficacy of ingested DSCG in the treatment of some gastrointestinal disorders.


Termination of Bacillus subtilis chromosome replication as visualized by autoradiography.


Testing acaricide susceptibility of the brown dog tick, Rhipicephalus sanguineus (Latreille, 1806), with a disposable pipette method.


Successful enforcement of an immunization law.


The carbohydrate composition of glycopeptides isolated from IgA2 immunoglobulin.


The colicin K of Escherichia coli K235.

The colicin K of Escherichia coli K235.


The cortical response in Xenopus laevis ova.


The control of plasma glucose in the surgical patient.


The determination of size and molecular weight of casein micelles by means of light-scattering and electron microscopy.


The economics of rehabilitation.

The economics of rehabilitation.


The effect of bilirubin on the assay of gentamicin. An experiment was set up to examine the effect of ;jaundiced' serum on the estimation of gentamicin levels in serum. Varying amounts of gentamicin were assayed in the presence of a range of bilirubin concentrations and compared with assayed levels in normal serum.


The effect of cobalt-60 radiation on the dental pulps of monkeys.


The characteristics of volunteers in crisis intervention centers.


The effect of diphenylhydantoin on thyroid function.


The effect of early cyclophosphamide treatment on the subsequent immunity of chickens to coccidial infections.


The effect of fermentation conditions on the filtration characteristics of fermented broths.


The effect of microorganisms and sorption on the protease activity of plant roots.


The effect of immunosuppression on the development of immunity to fowl typhoid.


The effect of phototherapy on the hyperbilirubinemia of rhesus incompatibility.


The effect of physiological conditions on the synthesis of the cell wall and disintegration of Bacillus megaterium.


The effect of uneven dietary protein to calorie distribution on nitrogen retention and weight gain.


The effect of pyrithioxine and pyridoxine in rats with early protein or calorie malnutrition. 3. Individual behavior of adult rats in relation to different stimulus intensity of observation box.


The effect on reproduction in female rabbits of antibodies to a specific autoantigen in the secretions of the male accessory sex glands.


The fibrin(ogen) degradation products and platelets in meningococcal infection.


The effects of centrophenoxine and palmitoyl ethanolamide on individual activity in rats with early protein or calorie malnutrition.


The fractionation of maternal serum by means of ion-exchange chromatography.


The function of the endosymbiotic bacteria of blattoidea.


The functional morphology of the coronary microcirculation in the dog.


The genetic identification of a heterochromatic segment on the X chromosome of Drosophila melanogaster. An autosomal euchromatic maternal-effect mutant, abo (= abnormal oocyte), interacts with, or regulates the activity of, the heterochromatin of the sex chromosomes of Drosophila melanogaster. It is shown that this interaction or regulation with the X chromosome involves a specific heterochromatic locus or small region that maps to the distal penultimate one-eighth of the basal X-chromosome heterochromatic segment.


The gut-associated lymphoid system: nature and properties of the large dividing cells.