At-risk register.

At-risk register.


Epidemiology of gallstone disease.

Epidemiology of gallstone disease.


Mortality in urinary schistosomiasis.

Mortality in urinary schistosomiasis.


Spontaneous intracerebral haematoma in a patient undergoing haemodialysis.


Dilution and transfusion.

Dilution and transfusion.


Coordinated care of the child with spina bifida.


Virus-like particles in infectious hepatitis.


Au antigen in liver cirrhosis.

Au antigen in liver cirrhosis.


Aplastic anaemia and infectious hepatitis.


Infectious hepatitis and Down's syndrome.


H.A.A. at the barber's?

H.A.A. at the barber's?


Tropical sprue in Africa.

Tropical sprue in Africa.


Intestinal transport of fructose.

Intestinal transport of fructose.


Carrageenan: effects in animals.

Carrageenan: effects in animals.


Serum gamma-glutamyl transpeptidase as a diagnostic aid.


Preservation of serum-acid-phosphatase.

Preservation of serum-acid-phosphatase.


Junior hospital staff in training.

Junior hospital staff in training.


Effect of propranolol on serum-thyroxine.


Lay hypochondria.

Lay hypochondria.


Effect of allopurinol on pyrimidine metabolism in the Lesch-Nyhan syndrome.


Abnormal pharmacokinetics of phenytoin in a patient with uraemia.


Delayed psychosis due to L.S.D.

Delayed psychosis due to L.S.D.


Sex-chromatin and menstrual cycle.

Sex-chromatin and menstrual cycle.


Small blood-vessels in migraine.

Small blood-vessels in migraine.


Register of interpreters.

Register of interpreters.


Rapid axonal transport of sulfated mucopolysaccharide proteins. When sulfur-35-labeled sodium sulfate is injected intraocularly in the goldfish, labeled sulfated mucopolysaccharides rapidly appear in the contra-lateral optic tectum of the brain, demonstrating the axonal flow of sulfated mucopolysaccharides. The transport rate is the same as that observed for proteins labeled after intraocular injection of tritiated proline. Treatment of the sulfur-35-labeled material with precipitants and enzymes reveals the presence of substances with properties similar to those of heparan sulfate (the major component) and chondroitin sulfate. Dermatan sulfate was not detected.


Radioresistance of cooperative function of carrier-specific lymphocytes in antihapten antibody responses. Transfer of lymphoid cells from strain-2 guinea pigs immunized to bovine gamma globulin into syngeneic recipients immunized with dinitrophenyl ovalbumin markedly enhances the secondary antidinitrophenyl response of the recipient to challenge with dinitrophenyl-bovine gamma globulin. This function of the carrier bovine gamma globulin-specific cells is resistant to irradiation with up to 5000 rads, although the capacity of the irradiated cell population to transfer immunologic memory for bovine gamma globulins or to be stimulated by antigen to synthesize DNA in vitro is abolished by this treatment.


Tumors of the skin. Considerations on total excision.


Benzene hexachloride poisonong.

Benzene hexachloride poisonong.


Studies on comparison of staining of Treponema pallidum with that of Borrelia recurrentis as seen from long-term preservation of the specimen. II. Negative staining.


Study on histologic changes of periodontal membrane incident to experimental tooth movement.


Automation of a quantitative immunochemical microanalysis of human serum transferrin: a model system.


A simple way to index, file and retrieve slides.


Current concepts of the pathogenesis and management of asthma.


Rubella vaccine.

Rubella vaccine.


Induction of T antigen, new surface antigen, and transplantation immunity by a nontumorigenic variant of type 3 bovine adenovirus.


Slides add emphasis to food service training program.


Studies on the morphopoiesis of the head of bacteriophage T-even. 8. Multilayered polyheads.


Electron microscope observations on actomyosin and actin preparations from Physarum polycephalum, and on their interaction with heavy meromyosin subfragment I from muscle myosin.


Preservation of intercellular substances by the cationic dye alcian blue in preparative procedures for electron microscopy.


The drops of life: fluids and electrolytes.


The drops of life. I.V. therapy as a nursing responsibility.


Good-by, Mary.

Good-by, Mary.


Hypervolaemia in status asthmaticus.

Hypervolaemia in status asthmaticus.


RN reports from Chicago.

RN reports from Chicago.


Effect of L-dopa on seborrhoea of parkinsonism.


Death is a family matter.

Death is a family matter.


Diagnosing thyroid carcinoma.

Diagnosing thyroid carcinoma.


Abortion: a stormy subject.

Abortion: a stormy subject.


A multi-media curricular approachin the making.


Carcinogenic natural products.

Carcinogenic natural products.


Irradiated humans: microbial flora, immunoglobulins, complement (C'3), transferrin, agglutinins, and bacteriocidins.


"Plotting" the basic curriculum.

"Plotting" the basic curriculum.


The OR nurse in the patient care circuit.


Editorial: the challenge and the future in nursing.


Anesthesia for the aged.

Anesthesia for the aged.


Change--can nursing make it?

Change--can nursing make it?


An historical review of "Die Symbolik des Traumes". (Chapters I-VI).


Idiopathic infantile arterial calcification--a misnomer?


Selective zinc iodide-osmium tetroxide impregnation of synaptoid vesicles in the rat neurohyophysis.


Thyroid function tests: a review.

Thyroid function tests: a review.


Increased glycogen accumulation in normal stimulated lymphocytes in vitro by modifying the conditions of cultivation.


A comparative cytochemical study of leukocytes of some animal species.


Bone marrow and spleen interrelation in local irradiation: data of cytometry and Fe59 incorporation.


The acid-base conditions of ACD blood during storage.


Naturally occurring anti-CW antibody and the frequency of the CW antigen in blood donors of the county Pest.


Effects of deleterious oral habits on the dento-facial complex.


Clinical and metabolic study in hypothyroidism.


Modern management of the Rh incompatible pregnancy.


Seminar on care of the newborn. IV. Newborn hematologic problems.


The quantitation of nerve biopsy findings.


Cytology of the tonsils.

Cytology of the tonsils.


The effect of experimental constriction on the structure of the sciatic nerve.


Balloon atrial septostomy in complete transposition of the great vessels.


Rhabdomyosarcoma of the middle cranial fossa.


Technical aids in surgery. The palliative operation for obstructive jaundice due to carcinoma of the pancreas.


Evaluation of EDTA as the chelator in the biuret reagent.


Clinical and immunological studies following immunotherapy with aqueous and alum precipitated reagweed fraction A.


The decision making process in cancer patient care.


IgE levels, antibodies against smooth muscle and eosinophilia in asthmatic patients and normal controls.


IgE levels in external secretions.

IgE levels in external secretions.


Classes in oncology: George Nicholas Papanicolaou's new cancer diagnosis presented at the Third Race Betterment Conference, Battle Creek, Michigan, January 2-6, 1928, and published in the Proceedings of the Conference.


Membrane antigens of human colonic carcinoma and non-tumoral colonic mucosa: results obtained with a new isolation method.


The therapeutic dietitian's role in the Alimentation Group.


Relationship between a metabolic rhythm and emergence rhythm in Drosophila melanogaster.


Physiological factors in the courtship processing of Drosophila melanogaster.


Morphogenetic effects of juvenile hormone and juvenile hormone mimics on adult development of Drosophila.


Effects of protein-calorie malnutrition on drug metabolism in rat liver microsomes.


The separate effects of protein and calorie malnutrition on the development and growth of rat bones and teeth.


Quantitative comparison of biological dressings.


Carotid perfusion hypothermia for brain surgery using cardiac arrest without bypass.


George Nicholas Papanicolaou (1883-1962).


Neurologic disorders following live measles-virus vaccination.


Professional standards review organizations. Analysis of their development and implementation based on a preliminary review of the Hospital Admission and Surveillance Program in Illinois.


Clinical and physiopathological considerations on the hyperosmolar states with or without ketoacidosis.


Whole body counter studies of iron absorption in patients with subtotal gastrectomy.


The use of a nonabsorbable indicator ( 51 CrCl 3 ) method for measuring  14 C-labelled fatty-acid absorption in the intestine.


Lower pH limit for the existence of blue-green algae: evolutionary and ecological implications. Observations on a wide variety of acidic environments, both natural and man-made, reveal that blue-green algae (Cyanophyta) are completely absent from habitats in which the pH is less than 4 or 5, whereas eukaryotic algae flourish. By using enrichment cultures with inocula from habitats of various pH values, the absence of blue-green algae at low pH was confirmed.


Sexual differentiation of pituitary function: apparent difference bewteen primates and rodents. Surges in luteinizing hormone secretion resembling those which occur spontaneously during the menstrual cycle were induced by acute elevations in circulating estrogen concentrations in both male and female rhesus monkeys gonadectomized in adulthood. These experiments demonstrate that in primates, in contrast to rodents, exposure of the hypothalamohypophyseal unit to androgens throughout fetal and postnatal development does not prevent the differentiation of the control system that governs cyclic gonadotropin secretion.


Sexual behavior in rhesus monkeys after vasectomy. Vasectomy had no statistically significant effect on the sexual behavior of vigorous adult rhesus monkeys. Of two groups of males matched for level of sexual performance, one was vasectomized and the other underwent sham vasectomy. In sex tests administered within the month after surgery, the groups showed no difference (P .05) in rate of mounting, intromission, or ejaculation, or in any other measure of sexual or sex-related behaviors.


Motor cortex reflexes associated with learned movement. In primates, sensory input can generate reflex motor cortex output in association with learned movement when the sensory input has a strong and direct connection to the motor cortex-for example, when a stimulus calling for repositioning of the hand consists of a perturbation of hand position. This finding supports the proposal that neurons of primate motor cortex may function in a transcortical servo-loop.


Polychlorinated biphenyl- and triphenyl-induced gastric mucosal hyperplasia in primates. Polychlorinated biphenyl or triphenyl ingestion by subhuman primates for 3 months produced hyperplasia and dysplasia of the gastric mucosa. The concentration of the biphenyl within the experimental diet was less than an order of magnitude greater than that occurring in random food samples sold in the United States and less than levels which have occurred in food products as a result of industrial accidents. The increased cellularity, abnormal dysplastic growth pattern, and invasion of the adjacent tissue region indicate compromised gastric function and are suggestive of an eventual neoplastic transformation.


Reproductive function in the human male. Report of a WHO scientific group.


The Medical Society of Copenhagen 1772-1972.


Health hazards in the use of the laser microprobe for toxic and infective samples.


The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience.


Oxidation of catechol in plants. 3. Purification and properties of the diphenylene dioxide 2,3-quinone-forming enzyme system from Tecoma leaves.


Fat metabolism in higher plants. LVI. Distribution and nature of biotin in chloroplasts of different plant species.


The characterization and regulatory properties of pyruvate kinase from cotton seeds.


Structure and function of amylases. II. Multiple forms of bacillus subtilis  -amylase.


Carbonic anhydrase catalyzed oxygen-18 exchange between bicarbonate and water.


Recovery of function: implications for theories of brain function.


The effects of vibratory and electrical stimulation on habituation in the ciliated protozoan, Spirostomum ambiguum.


The hippocampus and behavioral maturation.


The involvement of calcium in contractility in the ciliated protozoan, Spirostomum ambiguum.


Fluorescence polarization and pigment orientation in photosynthetic bacteria.


Role of cell wall antolysin in chain formation by a mutant strain of Streptococcus faecalis.


Effects of calcium and bound sialic acid on the viscosity of mucin.


Representation of the cochlear partition of the superior temporal plane of the macaque monkey.


Sulfatide synthesis in neurons: a defect in mice with a hereditary myelination disorder.


Distinct projections to the red nucleus from the dentate and interposed nuclei in the monkey.


Lithium stimulates secretion of acetylcholine in the absence of extracellular calcium.


Brain amino acids in baboons with light-induced epilepsy.


Human prolactin.

Human prolactin.


Isolation and partial characterization of immunoglobulin from a urodele amphibian (Necturus masculosus).


The bentonite granuloma. Characterization of a model system for infectious and foreign body granulomatous inflammation using soluble mycobacterial, histoplasma and schistosoma antigens.


Quantitative analysis of activity in eye muscle motoneurons during saccadic eye movements and positions of fixation.


Influence of saccadic eye movements on unit activity in simian lateral geniculate and pregeniculate nuclei.


Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.


GLC determination of nitroglycerin and isosorbide dinitrate in human plasma.


Kinetics of  -lactamase inactivation of penicillins I: effect of side-chain structure, ionic strength, pH, and temperature.


Selenium heterocycles. 8. Synthesis and antibacterial activity of selenosemicarbazide and 1,3,4-selenadiazolylcarbamic acid esters.


Field application of immunodiffusion and complement fixation tests for diagnosis of equine infectious anemia.


Relationship between histopathological and serological findings in field cases of equine infectious anemia.


Some characteristics of high macarbomycin-resistant mutants of Escherichia coli isolated from gnotobiotic pigs.


Short term heritable changes affecting viability in Drosophila melanogaster.


Blood carbonic anhydrase activity in the newborn.


Total intravenous nutrition. Experience with fat emulsions and hypertonic glucose.


Prevention of postoperative ketosis in the diabetic. Use of high-caloric intravenous solutions.


Venobronchial fistula. A rare complication of central venous catheterization for parenteral hyperalimentation.


Photic stimulation and visual physiology: implications for behavioral studies.


Reversal learning in the developing malnourished rhesus monkey.


H-2 histocompatibility alloantigens. Some biochemical properties of the molecules solubilized by NP-40 detergent.


RNA polymerase from vegetative cells and spores of Bacillus cereus T. II. Peptide composition.


The reaction of hydroxylamine with 4-thiouridine.


The regulation of cell growth. I. Identification and partial characterization of a DNA synthesis stimulating factor from the serum of partially hepatectomized rats.


Exploratory behavior of cebus monkeys after having been reared in partial isolation.


Colour coding in rhesus monkey prestriate cortex.


Tacitin: a preliminary evaluation in chronic alcoholic patients presenting the target symptomatology of anxiety.


Thioridazine for newly admitted psychiatric patients.


Clinical evaluation of a possible catechol-O-methyl transferase inhibitor in endogenous depression.


Topical clotrimazole in dermatophytosis.


U-28,774 (ketozolam): an early evaluation of a new antianxiety agent.


The use of fluphenazine enanthate in psychotic patients.


Chlorazepate dipotassium in the treatment of anxiety associated with chronic gastrointestinal disease.


A double blind, phase I clinical study oxazepam and protriptyline combined.


Hemocytic changes associated with the encapsulation and melanization of some insect parasites.


The cutaneous mucinoses.

The cutaneous mucinoses.


Mast cell infiltrates of the skin and the mastocytosis syndrome.


Temperature-sensitive initiation of chromosome replication in a mutant of Bacillus subtilis. A mutant of Bacillus subtilis Ts37 has been isolated in which deoxyribonucleic acid (DNA) synthesis is inhibited at high temperature. The results presented here indicate that the process of initiation of DNA replication is temperature sensitive in this mutant. After shifting to 45 C, DNA increases 40 to 50% before synthesis ceases; an inhibition of protein synthesis permits an equivalent amount of DNA to be synthesized. A density shift experiment coupled with a marker frequency analysis shows that DNA synthesized at 45 C is highly enriched in the markers situated at the end of the chromosome. Transforming DNA extracted from a culture which has been incubated at 45 C exhibits the relative transforming efficiency for origin and terminus markers characteristic of completed chromosomes. After a shift back from 45 C to 30 C, reinitiation appears to occur always in the same region of the bacterial chromosome; in addition, replication as well as cell division is synchronized.


Acid-base titration of streptococci and the physical states of intracellular ions. Acid titrations of intact and butanol-treated cells of Streptococcus faecalis revealed that nearly all of the intracellular K(+) ions could diffuse into the suspending medium in association with small anions, including ribonucleic acid breakdown products, when the cell membrane was damaged. In contrast, nearly all of the intracellular Mg(2+) ions appeared to be firmly bound to stable internal cell components but could be displaced reversibly by hydronium ions. The cell membrane acted as a barrier to ion movements, and Mg(2+) displacement from intact cells required more acid conditions, by as much as 2.5 pH units, than did displacement from butanol-damaged cells. Some 15 to 20% of the cell magnesium appeared to be associated with surface structures in that it could be removed at pH 7 with ethylenediaminetetraacetic acid or displaced by Co(2+), Ni(2+), Sr(2+), or La(3+). Magnesium could be displaced from isolated cell walls and membranes by hydronium ions in the pH range from 5 to 3, over which carboxyl groups were titrated. Displacement of magnesium from ribosomes also took place between pH 5 and 3, but it was more difficult to identify the magnesium-releasing groups because both protein carboxyl groups and purine and pyrimidine ring nitrogens can become protonated in this pH range. Isolated protoplast membranes remained structurally intact when completely depleted of magnesium. Furthermore, protoplasts isolated from intact cells were found to have greatly enhanced resistance to osmotic shock in acid media, even when solute loss was not extensive. Osmotic resistance was lost when the protoplasts were again placed in neutral media, and this reversibility suggested that acidification caused changes in the physical properties of membranes as well as solute leakage from cells.


Macromolecular syntheses during germination and outgrowth of Bacillus subtilis spores. Alanine and glucose used jointly are known to be necessary and sufficient for spore germination in Bacillus subtilis 168. By testing them separately, we have verified that alanine provokes optimal phase-darkening of the spores but inhibits macromolecular syntheses, while glucose is specifically needed for initiating those syntheses. By using them in succession we obtained evidence suggesting that: (i) sporal modifications which lead to phase-darkening must occur before macromolecular synthesis can start; (ii) the amino acid pool, on which the early protein synthesis is solely dependent, expands during incubation in alanine which allows degradative but prevents synthetic activities; and (iii) progression of degradations in alanine not promptly followed by syntheses in glucose produce a metabolic imbalance in the germinating spore. A sharp transition in the origin of building blocks was shown by using a tryptophan-defective mutant. At first the synthesis of proteins depended on pre-existing amino acids from turnover of sporal material since it occurred in the absence of any exogenous amino acid and its rate remained unaltered by supplying either all amino acids except tryptophan or tryptophan alone. Eventually, protein synthesis became dependent strictly on exogenous tryptophan and strongly on the supply of several other amino acids, not required later during vegetative growth. Clearly, by the start of outgrowth, all building blocks must be provided either by endogenous de novo synthesis or by exogenous supply.


Inactivation of aspartic transcarbamylase in sporulating Bacillus subtilis: demonstration of a requirement for metabolic energy. The aspartic transcarbamylase (ATCase) activity of Bacillus subtilis cells disappears rapidly from stationary-phase cells prior to sporulation. ATCase activity does not appear in the culture fluid during the stationary phase; hence the enzyme appears to be inactivated in the cells. The enzyme is inactivated normally in two different mutants lacking proteases; the activity is very stable in crude extracts of cells or in the culture fluid. These results suggest that ATCase is not inactivated by the general proteolysis that occurs in sporulating bacteria. The inactivation of ATCase can be completely inhibited after it has begun by oxygen starvation or addition of fluoroacetate. Inhibitors of oxidative phosphorylation and electron transport also interrupt the inactivation of ATCase. The inactivation of ATCase is very slow in two mutant strains that are deficient in enzymes of tricarboxylic acid cycle. Addition of gluconate to stationary cultures of the mutant strains, which is known to restore depleted adenosine 5'-triphosphate pools in these bacteria, also restores inactivation of ATCase. These experiments support the conclusion that the generation of metabolic energy is necessary for the inactivation of ATCase in stationary cells. ATCase activity is stable in growing cells in which ATCase synthesis is repressed by addition of uracil; the enzyme is inactivated normally, however, when such cells cease growing.


Penicillin-binding component of Bacillus cereus. (14)C-penicillin is irreversibly bound by Bacillus cereus 569. Incubation of penicillin-treated cells in a cell wall digestion medium results in solubilization of approximately 60% of the irreversibly bound lable. The extent of the solubilization is the same when cells are prepared by either a cold or 37 C treatment procedure. However, spheroplasts prepared by the cold treatment are leaky. When the resulting spheroplasts are incubated in supplemented medium, reduced rates and levels of penicillinase synthesis, relative to induced whole-cell controls, are observed. Spheroplasts from both cold and 37 C prepared cells exhibit this phenomena, although the spheroplasts from 37 C prepared cells synthesized approximately sixfold higher levels of penicillinase. The size distribution of the label solubilized during the preparation of spheroplasts was examined by using Bio Gel P-150 columns. Although no label appeared in the exclusion volume fractions when the cell wall digest of the 37 C treated cells was chromatographed, approximately 10% of the label from cold-treated cells did appear. These results suggest that the presence of irreversibly bound penicillin is required for the synthesis of induced levels of penicillinase and that the irreversibly bound penicillin can be solubilized as a labile complex with material which is excluded from BioGel P-150. It may be concluded that the penicillin-binding lipoprotein complex which has been previously observed is the penicillin-specific binding site. However, the location of this complex in relation to the cell membrane could not be determined.


Association of many regions of the Bacillus subtilis chromosome with the cell membrane. Unsheared lysates of Bacillus subtilis 168T(-) containing uniformly labeled deoxyribonucleic acid (DNA) were exposed to varying doses of gamma rays to introduce double-strand scissions in the chromosome. From an estimate of the number-average molecular weight and the amount of DNA bound to membrane after irradiation, about 70 to 90 regions of the bacterial chromosome were detected in membrane fractions. Since this number was independent of the molecular weight of the DNA (i.e., the extent of fragmentation of the chromosome), it is thought to represent an upper limit in the number of membrane-binding sites per chromosome.


Induction of superoxide dismutase by molecular oxygen. Oxygen induces superoxide dismutase in Streptococcus faecalis and in Escherichia coli B. S. faecalis grown under 20 atm of O(2) had 16 times more of this enzyme than did anaerobically grown cells. In the case of E. coli, changing the conditions of growth from anaerobic to 5 atm of O(2) caused a 25-fold increase in the level of superoxide dismutase. Induction of this enzyme was a response to O(2) rather than to pressure, since 20 atm of N(2) was without effect. Induction of superoxide dismutase was a rapid process, and half of the maximal level was reached within 90 min after N(2)-grown cells of S. faecalis were exposed to 20 atm of O(2) at 37 C. S. faecalis did not contain perceptible levels of catalase under any of the growth conditions investigated by Stanier, Doudoroff, and Adelberg (23), and the concentration of catalase in E. coli was not affected by the presence of O(2) during growth. S. faecalis, which had been grown under 100% O(2) and which therefore contained an elevated level of superoxide dismutase, was more resistant of 46 atm of O(2) than were cells which had been grown under N(2). E. coli grown under N(2) contained as much superoxide dismutase as did S. faecalis grown under 1 atm of O(2). The E. coli which had been grown under N(2) was as resistant to the deleterious effects of 50 atm of O(2) as was S. faecalis which had been grown under 1 atm of O(2). These results are consistent with the proposal that the peroxide radical is an important agent of the toxicity of oxygen and that superoxide dismutase may be a component of the systems which have been evolved to deal with this potential toxicity.


Intergeneric complementation of anthranilate synthase subunits. Partially purified subunits of anthranilate synthase were prepared from Bacillus subtilis and Pseudomonas aeruginosa. The large component from B. subtilis (I(B)) complements well with the small component from P. aeruginosa (II(P)) to reconstitute a glutamine-reactive anthranilate synthase. This interaction can be demonstrated with crude extracts from a B. subtilis trpX mutant and a P. aeruginosa trpA mutant. Complementation was also observed with the large component from P. aeruginosa (I(P)) and the small subunit from B. subtilis (II(B)). At saturation the heterologous complex I(B)II(P) has 93% of the activity of the homologous complex I(B)II(B), whereas the hybrid I(P)II(B) is only 22% as active as the homologous complex I(P)II(P).


Effects of mutational loss of specific intracellular proteases on the sporulation of Bacillus subtilis. Two protease-deficient mutants of Bacillus subtilis 168 (Trp(-)) were isolated and compared with the parental strain with respect to production of intracellular proteases and sporulation. A mutant lacking the metal-requiring "neutral" protease intracellularly sporulated as well as the parental strain. A second mutant, deficient in an as yet uncharacterized intracellular protease, failed to sporulate normally. It is proposed that this new protease is also involved in intracellular protein turnover.


Characterization of the polydisperse closed circular deoxyribonucleic acid molecules of Bacillus megaterium. The polydisperse circular deoxyribonucleic acid (DNA) molecules which comprise up to 30% of the total extractable DNA of Bacillus megaterium strain 216 have been purified and partially characterized. Banding in cesium chlorideethidium bromide by "gradient relaxation" in a fixed-angle rotor provided good resolution of circular and chromosomal DNAs for preparative separations. Renaturation studies on purified circular DNA failed to reveal a rapidly renaturing fraction, and DNA-DNA hybridization studies indicated that the majority of the chromosomal nucleotide sequences are represented in the heterogeneous-size population of circular molecules. It is concluded that the circular DNA of B. megaterium does not represent typical bacterial plasmid DNA. The possibility that the circular DNA molecules are the result of the expression of a defective bacteriophage is discussed.


Role of intestinal microflora in the metabolism of guanidinosuccinic acid. Among a variety of bacteria isolated from the gastrointestinal tracts of rats and humans, only streptococci of group N are capable of degrading guanidinosuccinic acid added to their culture medium. The urinary excretion of guanidinosuccinic acid by germfree rats is greater than that of conventional rats. The excretion of this compound by gnotobiotic rats correlates with the capacity of their intestinal microflora to degrade guanidinosuccinic acid in culture. Thus, guanidinosuccinic acid excretion is low in rats infected exclusively with Streptococcus faecalis, and the excretion is not altered when germfree rats are infected with an organism unable to degrade guanidinosuccinic acid (Lactobacillus). These findings suggest that the intestinal microflora, particularly Streptococcus, play a role in the metabolism of guanidinosuccinic acid by the host.


Chorismate mutase from Streptomyces aureofaciens: a heat-stable enzyme. Chorismate mutase from Streptomyces aureofaciens was purified 12-fold. This enzyme preparation did not show any activity when tested for anthranilate synthetase, prephenate dehydrogenase, or prephenate dehydratase. The catalytic activity of chorismate mutase has a broad optimum between pH 7 and 8. The initial velocity data followed regular Michaelis-Menten kinetics with a K(m) of 5.3 x 10(-4) M, and the molecular weight of the enzyme was determined by sucrose gradient centrifugation to be 50,000. Heat inactivation of chorismate mutase, which occurs above temperatures of 60 C, is reversible. The enzyme activity can be restored even when chorismate mutase is treated at the temperature of a boiling-water bath for 15 min. Heat-denatured and renatured enzymes showed the same Michaelis constant and the same molecular weight as the native enzyme. l-Phenylalanine, l-tyrosine, l-tryptophan, and metabolites of the aromatic amino acid pathway were tested as potential modifiers of chorismate mutase activity. The activity of the enzyme was inhibited by none of these substances. Chorismate mutase of S. aureofaciens was not repressed in cells grown in minimal medium supplemented with l-phenylalanine, l-tyrosine, or l-tryptophan.


Escherichia coli mutants permissive for T4 bacteriophage with deletion in e gene (phage lysozyme). Escherichia coli mutants have been isolated that are permissive for the infection by T4 phage with deletion in the cistron for the phage lysozyme, the e gene. Some, but not all, of these mutants are simultaneously permissive for the infection by T4 phage defective in the t gene, the product of which has also been implicated in the release of progeny phages. Most of these mutants shared the following properties: temperature sensitivity in growth and cell division, increased sensitivity towards a number of unrelated antibiotics and colicins, and increased sensitivity towards anionic detergents (sodium dodecyl sulfate and sodium deoxycholate). The possible biochemical basis for these phenotypes is discussed.


Role of reduced exogenous organic compounds in the physiology of the blue-green bacteria (algae): photoheterotrophic growth of an "autotrophic" blue-green bacterium. The unicellular blue-green bacterium Agmenellum quadruplicatum strain BG-1 was found to be capable of rapid photoheterotrophic growth but unable to grow in the dark on a variety of reduced organic substrates. The generation time on glycerol was 12 h, and on CO(2), 3 h. Glycerol carbon was converted into cellular carbon with a very high efficiency. This high efficiency of carbon conversion, the action spectrum for growth on glycerol, cell pigmentation, gas exchange measurements, and immediate ability of photoheterotrophically grown cells to evolve O(2) (upon the addition of CO(2)) suggest the involvement of both photosystems I and II of photosynthesis during photoheterotrophic growth.


Role of reduced exogenous organic compounds in the physiology of the blue-green bacteria (algae): photoheterotrophic growth of a "heterotrophic" blue-green bacterium. Nostoc sp. (strain Mac) was shown to be capable of using glucose, fructose, or sucrose as a sole source of carbon and energy in the dark. In the light in the absence of exogenously supplied CO(2), this strain exhibited a more versatile metabolism. In addition to the three sugars above, glycerol and acetate served as sole sources of carbon. This photoheterotrophic growth in the absence of exogenously supplied CO(2) appears to involve O(2)-evolving photosynthesis. The action spectrum for photoheterotrophic growth on acetate closely resembles the action spectrum for photosynthesis. The physiology of photoheterotrophic growth was further investigated through determinations of stable carbon isotope ratios and measurements of gas exchanges. These investigations suggest that respired CO(2) from substrate oxidation is assimilated by the photosynthetic machinery.


Deoxyribonucleic acid-membrane complexes in the Bacillus subtilis transformation system. The fate of transforming deoxyribonucleic acid (DNA) in Bacillus subtilis was studied by isolating the DNA-membrane complex on Renografin gradients. Soon after uptake, transforming DNA binds to the cell membrane and displays a greater resistance to shear than the recipient genome-membrane complex. Ten minutes after uptake, a portion of the donor DNA is released from the membrane. Most of the released donor radioactivity represents unintegrated, biologically inactive DNA. Recombinant or integrated DNA is enriched 1.5- to 1.7-fold in the membrane. This enrichment last at least 30 min after termination of DNA uptake, and probably much longer. The data suggest that transforming DNA may be integrated into the recipient genome on, or close to, the cell membrane.


Structural difference between walls from hemispherical caps and partial septa of Bacillus subtilis. Walls from partial septa of Bacillus subtilis bacteria are more sensitive than end walls to digestion by B. subtilis autolytic amidase. This result indicates that, after synthesis, B. subtilis septal walls are modified to an amidase-resistant form.


Mutant of Bacillus subtilis with a temperature-sensitive autolytic amidase. A procedure incorporating a petri plate assay for autolysins has been developed for the systematic isolation of mutants with a temperature-sensitive autolytic amidase. We suggest maa as the name for the gene for this enzyme. One such mutant has been characterized as having a heat-sensitive amidase in a variety of studies with both crude autolysin preparations and purified amidase solutions.


Micrococcus lysodeikticus bacterial walls as a substrate specific for the autolytic glycosidase of Bacillus subtilis. The Bacillus subtilis 168 autolytic glycosidase degrades Micrococcus lysodeikticus cells or cell walls, whereas the B. subtilis autolytic amidase does not. The criteria used to establish this fact included: the determination of chemical bonds broken, heat-inactivated kinetics, pH dependence curves, and the physical separation of glycosidase from amidase. The physical separation involved LiCl elution from two different ion-exchange materials, walls from B. subtilis 168 strain betaAO, and walls from mutant strain betaA173 derived from strain betaAO. No evidence was obtained for B. subtilis vegetative bacteria making any more autolysins than one autolytic amidase and one autolytic glycosidase.


Large surface blebs on Escherichia coli heated to inactivating temperatures. Large surface blebs were observed with phase-contrast optics on Escherichia coli B/r and B(s-1) heated to temperatures at which colony-forming ability was lost. Characterization of such blebs was consistent with the view that they were formed by a physical process and were bounded by the outer membrane of the cell. A hypothesis for thermal inactivation of E. coli is presented that places membrane damage near the primary lethal event.


Stimulation of cell division by croton oil in blue-green bacteria. The potent tumor-promoting agent croton oil, which has been shown previously to be strongly mitogenic in mammalian cells, stimulates cell division in snake mutants of the blue-green bacterium Agmenellum quadruplicatum.


Minicells of Bacillus subtilis.

Minicells of Bacillus subtilis. After nitrosoguanidine (N-methyl-N'-nitro-N-nitrosoguanidine) mutagenesis, two Bacillus subtilis mutants (div IV-A1 and div IV-B1) were isolated that are defective in the location of division site along cell length. Both mutations were transferred into strain CU403 by transformation, and their properties were studied in the CU403 genetic background. Location of divisions in close proximity to cell pole regions in both mutants results in minicell production. Purified minicells contain a ratio of ribonucleic acid to protein comparable to that found in the parent cells. Autoradiographs of (3)H-thymine incorporation into deoxyribonucleic acid (DNA), thymine-2-(14)C incorporation into DNA, electron micrographs, and chemical analyses for DNA all fail to demonstrate DNA in the minicells. Minicells produced by both mutants are highly motile, an indication of functional energy metabolism. Electron micrographs reveal that minicells are produced by a structurally normal division mechanism and that minicells contain a normal cell surface. The div IV-A1 mutation has been mapped by PBS1 transduction linked to ura. The div IV-B1 mutation is closely linked to pheA by both PBS1 transduction and by co-transformation.


Influence of magnesium ions on porosity of the Bacillus megaterium cell wall and membrane. The presence of magnesium chloride (0.01 M) caused a relatively small but significant reduction in the equivalent porosity of the protoplast membrane, but not in that of the cell wall, in intact Bacillus megaterium cells.


Prolactin response to thyrotropin releasing hormone in normal subjects.


Changes in iodine metabolism and thyroglobulin structure in metastatic follicular carcinoma of the thyroid with hyperthyroidism.


L-dopa suppression of TRH-stimulated prolactin release in man.


Plasma growth hormone response to thyrotropin-releasing hormone in patients with active acromegaly.


The structure of the medial geniculate nucleus (MGN): a cyto- and myeloarchitectonic study in the squirrel monkey.


Control of responding by location of auditory stimuli: role of differential and non-differential reinforcement. Sound was presented to monkeys through one of two loudspeakers, each adjacent to a response key. A response on the key adjacent to the sound source was reinforced (correct response). A response on the other key produced a timeout (incorrect response). Under these conditions, over 90% of responses were correct within one or two sessions. When the procedure was changed so that a response on either key was reinforced independently of which speaker was sounding, similar control by location developed within one or two sessions. When conditions were modified by moving the keys away from the immediate vicinity of the speakers, the animals required about 20 sessions to reach a stable level of greater than 90% correct responses under differential reinforcement conditions. No control by location developed under nondifferential reinforcement conditions.


Behavioral assessment of pain detection and tolerance in monkeys. Cebus albifrons monkeys received electrical stimulation of the hindlimbs over a wide range of intensities. On trials signalled by a blue light, the animals were permitted to escape shock by pressing a disc, or shock was terminated after 8 sec (free escape). Escape force (disc pressure) was found to increase as stimulation intensity increased well beyond escape threshold, while shock duration curves reached plateau at the mid-range of intensities. The shock duration curves generated by free escape responses should be comparable to pain detection functions obtained by similar operations in humans, and the curves were stable over months of testing, as is generally found in pain-detection studies. On trials signalled by a red light, the animals received intense tail shock immediately after escape responses (punished escape), or, if they endured leg shock for 8 sec without escaping, then they could avoid tail shock with a panel press. The shock duration curves generated by punished escape responses should be comparable to pain tolerance functions as defined for human subjects, and the escape thresholds were considerably higher on red-light trials. As in human studies, the tolerance curves were not stable over repeated testing sessions, and some feature of the paradigm forced a progression toward extremely high levels of tolerance.


Operantly conditioned patterns on precentral unit activity and correlated responses in adjacent cells and contralateral muscles.


Hippocampal influence on unit activity of hypothalamus, preoptic region, and basal forebrain in awake, stting squirrel monkeys.


"Cold" fiber population innervating palmar and digital skin of the monkey: responses to cooling pulses.


Peripheral neural determinants of temperature discrimination in man: a correlative study of responses to cooling skin.


Survival of common bacteria in liquid culture under carbon dioxide at high temperatures.


A Rhesus incompatible baby.

A Rhesus incompatible baby.


The proximal negative response of the primate retina.


Estrogen formation by the isolated perfused rhesus monkey brain. Perfusion of two isolated brains from immature male rhesus monkeys with [(3)H]androstenedione resulted in the identification of free and conjugated [(3)H]estrone and free [(3)H]estradiol from the perfusates. In the dissected cerebral tissues, estrogens were recovered only from the hypothalamus and limbic system. The production of estrogens from androstenedione during the 40-minute perfusions in these two experiments totaled 1.58 and 2.83 nanograms.


Thyroidectomy cells and their response to thyrotrophin releasing hormone (TRH) in the rat.


Serum lysozyme in pulmonary tuberculosis.


Bullous retinal detachment. An unusual manifestation of idiopathic         central serous choroidopathy.


Hypothalamic hypothyroidism: diminished thyroidal response to thyrotropin-releasing hormone.


Cyclopia.

Cyclopia.


Pilocarpine uptake by pigmented uveal tissue.


Morphology of receptor innervation of spinal ganglia.


Experimental infections with African trypanosomes. V. Preliminary parasitological, clinical, hematological, serological, and pathological observations in rhesus monkeys infected with Trypanosoma rhodesiense.


Studies on the immunization of monkeys against dengue. I. Protection derived from single and sequential virus infections.


Studies on the immunization of monkeys against dengue. II. Protection following inoculation of combinations of viruses.


Vascular changes in the anterior uvea of the rabbit produced by prostaglandins.


Expandable silicone implants for scleral buckling. I. Introduction of a new concept.


Mitochondrial DNA from Drosophila melanogaster.


Postoperative wound infection in colonic and rectal surgery.


Long-term anticoagulant treatment after myocardial infarction. A review.


Acute alcoholic fatty liver in the Rhesus monkey.


Renal function in chronic intravascular haemolysis associated with prosthetic cardiac valves.


Peptide composition of human plasma apolipoproteins A, B and C.


Dietetics reaches out.

Dietetics reaches out.


Principles of viable preservation of parasitic Protozoa.


Immunospecific purification of human anti-IgM serum utilizing cord serum immunoadsorbent.


Babesia canis: the life cycle and laboratory maintenance in its arthropod and mammalian hosts.


Babesia argentina: the infectivity and immunogenicity of irradiated blood parasites for splenectomized calves.


Learning in monkeys after combined lesions in frontal and anterior temporal lobes.


Matching within and between sense modalities in the monkey (Macaca mulatta).


Dietary effect on liver fatty acid synthetase.


Osmotic opening of the blood-brain barrier in the monkey without associated neurological deficits. Hypertonic urea or lactamide solutions osmotically open the blood-brain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology.


Gas-filled structures providing buoyancy in photosynthetic organisms.


On the histogenesis of the cells in fracture callus. Electron microscopic autoradiographic observations in parabiotic rats and studies on labeled monocytes.


Catecholamine storage in liver metastases of a malignant carotid body tumour. A biochemical and morphological study.


Interactions between modified phage T4 particles and spheroplasts.


The development of TSH producing pituitary tumours in the mouse.


A method of central venous alimentation catheter placement for use in small infants.


Effect of nitrate, ammonia and nitrogen starvation on the regulation of nitrate reductase in Cyanidium caldarium.


A comparison of pre-operative and primary radiotherapy in the treatment of carcinoma of the hypopharynx.


Thoracic enteric cysts and diverticulae.


Massive haemorrhage in elephantiasis neurofibroma.


Enzyme typing of malaria parasites.

Enzyme typing of malaria parasites. Analysis of various isolates of Plasmodium falciparum from East and West Africa and from South-east Asia showed that some of the parasite enzymes can exist in more than one electrophoretic form. At least one form of each enzyme was common to parasites from all three regions. The enzyme forms could be used to differentiate morphologically indistinguishable samples of P. falciparum.


Experimental infection of animals with influenzavirus types A and B. The knowledge that domestic cats were susceptible to infection with freshly isolated A/Hong Kong/68 influenzavirus led to studies on the susceptibility of some other animal species to this virus, as well as to studies on the ability of egg-passaged Hong Kong virus and an Asian virus to infect cats. The ability of a recent isolate of influenzavirus B to infect these animals was also studied. Macaca radiata monkeys could be infected with fresh isolates of A/Hong Kong virus by intranasal instillation or by contact with infected animals. They could also be infected with influenzavirus B by intranasal challenge, but contact transmission was not demonstrated. Mongrel dogs were found to be susceptible to A/Hong Kong/68 virus by intranasal instillation, but not to type B virus. Domestic cats could be infected with A/Hong Kong/68 virus passaged 6 times in eggs. They were also susceptible to infection with an established laboratory strain of Asian virus. Cats could be infected with influenzavirus B either by intranasal challenge or by contact with infected animals. In no case was clinical illness found following infection, but the infected animals shed virus from the throat and developed haemagglutination inhibiting antibodies.


Anthrax.

Anthrax.


Temperature-dependent transition in L-histidine ammonia-lyase.


Fractionation of chromatin components.

Fractionation of chromatin components.


Various blood glucose values in the rat.


Preparation of 125I-labelled thyrotrophin-releasing hormone.


Falsely high fluorescence in cortisol determinations due to the carbamazepine.


Different amounts of insulin secretion following an equal total decrease of blood glucose as an indication of possible extrapancreatic activities of different sulfonylurea drugs.


The microbiologic determination of serum folic acid activity. I. Study of the assay system.


A trial of haemagglutination, circumoval precipitin and gel diffusion tests in hookworm infection.


Effect of cortisone on immunologic cardiac injury in albino rats.


The immune response of a cyprinid fish to infections of the acanthocephalan Pomphorhynchus laevis.


Measurement of the infectivity of Trypanosoma cruzi in faeces of Rhodnius by comparison of dose-response curves.


United States-Japan cooperative drug abuse study.


Function of the alpha cell in diabetic ketoacidosis.


Auditory processing of biologically significant sounds.


Effects of chlordiazepoxide upon successive red-green discrimination responses in Japanese monkeys, Macaca fuscata.


Fine structure of the chloroplast membranes of Euglena gracilis as revealed by freeze-cleaving and deep-etching techniques.


The handling of contaminated abdominal wounds.


Ultrastructure and ion distribution of the intestinal cell during experimental vitamin-D deficiency rickets in rats.


Fatal necrotizing angiitis after sulfadimethoxine therapy presenting as anaphylactoid purpura.


Regional variations in mouse skin: quantitation of epidermal compartments in two different body sites.


Puzzling structures in the renal glomeruli of 13 patients. An electron microscopical study.


Procedures in radiation therapy dosimetry with 5 to 50 MeV electrons and roentgen and gamma rays with maximum photon energies between 1 and 50 MeV.


Genealogical mating activity in free-ranging groups of rhesus monkeys (Macaca mulatta) on Cayo Santiago.


In vitro synthesis of DNA spontaneously released by bacteria or frog auricles.


Electroanesthesia studies: cerebral blood flow and oxygen utilization during electroanesthesia in the rhesus.


Ophthalmic care in Greenland.

Ophthalmic care in Greenland.


The ocular inflammation produced following intravitreal injection of a stable L-phase variant of Neisseria meningitidis.


Echovirus type 17 in the neonate.

Echovirus type 17 in the neonate. An outbreak of echovirus type 17 in a neonatal nursery with recovery of virus from the stools of the seven affected infants and the cerebrospinal fluid of one is described. Intensive nursing care and supportive therapy prevented a possible fatal outcome in all instances. A further case in another community is described in which a 5-week-old child succumbed to his illness and echovirus type 17 was isolated from autopsy tissues - lung, liver, kidney and spleen. This child had presumably received poor home care. The suggestion is made that while echovirus type 17 is not frequently associated with adult disease, it may exhibit affinity for infant tissues. This is thought to be the first time that this virus has been associated with clinical disease in a neonatal nursery and also the first account of its recovery from postmortem tissues.


Cytotoxic effect of dimethylsulfoxide on the ultrastructure of cultured Rhesus kidney cells.


Characteristics of the pituitary binding sites for thyrotropin releasing factor.


Gonadal function and the biological and physicochemical properties of follicle stimulating hormone.


Radioimmunoassay of rhesus monkey follicle stimulating hormone (RhFSH).


Hyperthyroidism induced by thyrotropin-releasing hormone in mice.


Induced LH surges in the rhesus monkey: strength-duration characteristics of the estrogen stimulus.


Grading of protein calorie malnutrition.


The kinetics of the killing of mouse tumour cells in vivo by immune responses.


Genetic properties of substituted derivatives of N-methyl-4-aminoazobenzene in relation to azo-dye carcinogenesis.


Cellular immunity to human urinary bladder carcinoma. I. Correlation to clinical stage and radiotherapy.


Cellular immunity to human urinary bladder carcinoma. II. EEffect of surgery and preoperative irradiation.


Induction of delayed-type sensitivity-like reactions in the eye by the injection of lymphokines.


Prostaglandin synthesis, inhibition, and intraocular pressure.


The effect of arterial PCO2 on inner-retinal oxygen availability in monkeys.


The effect of arterial PCO2 on inner-retinal oxygen consumption rate in monkeys.


Treatment of defects of the ulna in children by establishing cross-union with the radius.


Dome fracture of the talus. A report of ten cases.


Activity of aminoglycoside antibiotics aganst Pseudomonas aeruginosa: specificity and site of calcium and magnesium antagonism.


Immunology of Escherichia coli: K antigen and its relation to urinary-tract infection.


Comparative activity of sisomicin against mycobacteria in vitro and against Mycobacterium tuberculosis in mice.


Fetal-maternal plasma calcium relationships in rat and sheep.


A survey to assess potential human disease hazards along proposed sea level canal routes in Panamá and Colombia. I. Introduction.


A survey to assess potential human disease hazards along proposed sea level canal routes in Panamá and Colombia. II. geography of proposed routes.


Problems in interpreting tuberculin skin tests. When is a converter not a converter?: a review.


Pyrimethamine-induced leukopenia and thrombocytopenia in a patient with malaria and tropical sprue: case report.


Building a new wing.

Building a new wing.


Case for diagnosis: focal interstitial myocarditis.


The development of a MHCS role in race relations.


Mental hygiene command consultation program at an army training center.


Experience with drug abuse.

Experience with drug abuse.


A clinical evaluation of 81 heroin addicts in Vietnam.


Neuroepidemiology.

Neuroepidemiology.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1973.


Effects of testosterone treatment in adulthood on sexual behaviour of female pseudohermaphrodite rhesus monkeys.


Validity of the quadratic fitness function.


Complications of total hip replacement arthroplasty.


Early results of Charnley-Müller total hip reconstruction.


The Amsel frustration effect: interpretations and research.


Enhanced emigration of crevicular leukocytes mediated by factors in human dental plaque.


Observations on endopeptidases in human carious dentin.


Respiratory disease and ABO and rhesus blood groups.


Long term maintenance of Theileria annulata strains by freezing at -70 degrees C.


Hemophilia B in a phenotypically normal girl with XX (ring) XO mosaicism.


Abnormal factor X(factor X Friuli) coagulation disorder.


Hypofibrinogenemia after Echis colorata bite in man.


Heinz body susceptibility of red cells and exchange transfusion.


Factors influencing the uptake of vitamin B 12  by normoblastic and vitamin B 12 -deficient bone marrow cells.


The fibrinolytic enzyme system in malignant lymphomas.


Whole-body autoradiography of   1-tetrahydrocannabinol and   1(6)-tetrahydrocannabinol in mouse. Pharmacokinetic aspects of   1-tetrahydrocannabinol and its metabolites.


Factors influencing the secretion of human prolactin and growth hormone in menstrual and gestational women.


Porcine coronaviruses: co-infection of cell cultures with transmissible gastroenteritis virus and hemagglutinating encephalomyelitis virus.


Heteroxanthin in Euglena gracilis.

Heteroxanthin in Euglena gracilis.


Action of lysozyme on Anabaena ambigua Rao.


Isolation of and production of antibody to cow chromaffin granule membrane.


Membranes of Tetrahymena. 3. The effect of temperature on membrane core structures and fatty acid composition of Tetrahymena cells.


An ultrastructural study of the red pulp of the spleen in malaria.


Occlusion of the vortex veins. An experimental study.


The Cancer Control Program of the National Cancer Institute.


A comparison of different compounds for TBG-blocking used in radioimmunoassay for tri-iodothyronine.


Unproven methods of cancer management. Krebiozen and carcalon.


A new extrapigmentary effect of alpha-MSH. Promotion of sodium uptake in the heart of toads and rats.


Cookbook cancer therapy.

Cookbook cancer therapy.


A study of immunoglobulins in protein calorie malnutrition.


Immunoglobulins and C 3  levels in normal Indians: details of methodology, standardization, variation and statistical methods.


A new simplified sugar medium for fermentation test with plague, pseudotuberculosis and diphtheria organisms.


Colorectal polyps.

Colorectal polyps.


Rx of bladder cancer: complex and controversial.


Viability of N. gonorrhoeae in transport media.


An approach to the control of carcinoma of the endometrium.


The treatment of wounds with special reference to the value of the blood clot in the management of dead space. IV. Operations for carcinoma of the breast by William S. Halsted, M.D., reprinted from Johns Hopkins Hospital Reports, Vol. II, No. 5, 277-280, 1891.


Vaccine trials for osteogenic sarcoma. A preliminary report.


Peripheral ossifying fibroma: report of case.


Preservation and biodegradation of the morphogenetic property of bone matrix.


"Rynacrom" (sodium cromoglycate).

"Rynacrom" (sodium cromoglycate).


William Stewart Halsted (1852-1922).

William Stewart Halsted (1852-1922).


Inpatient surgery on an ambulatory basis.


Serum concentrations of ampicillin in newborn infants after oral administration.


Protein calorie malnutrition and infection with hepatitis-associated antigen.


Hyperammonemia: another hazard in parenteral alimentation.


Nasogastric tube feedings. Practical considerations in prescription and evaluation.


Nutritional care after head and neck surgery.


Changing concepts in prenatal care.

Changing concepts in prenatal care.


Virus-like particles in natural scrapie of the sheep.


The use of fluorescent antibody technqiues to detect Theileria parva in the salivary glands of the tick Rhipicephalus appendicalatus.


Observations on the haematology of experimentally induced Babesia argentina and B. bigemina infections in splenectomised calves.


Haemoglobin reactive protein in cattle: partial characterisation.


Chemical and microbial degradation of ten selected pesticides in aquatic systems.


Laboratory experiments with uropathogenic bacteria and chlorhexidine.


Metabolism of radioactive-labeled fat emulsions in the postoperative and posttraumatic period.


Vitamin B 12  absorption in protein-calorie malnourished children and during recovery: influence of protein depletion and of diarrhea.


Malnutrition studies in Macaca mulatta. II. The effect on organ size and skeletal growth.


Communication among primates.

Communication among primates.


Heart: excitation-contraction coupling.

Heart: excitation-contraction coupling.


Normal tissue tolerance to particle and heavy ion radiation.


The DNA of Tetrahymena pyriformis GL strain. A mild method for preparation and its characterization.


Immunologic studies on intracellular isoenzymes; the mitochondrial and cytoplasmic leucyl-tRNA synthetases.


Value of immunodiffusion tests in the diagnosis of systemic mycotic diseases.


A comparison of effective thyroxine ratio and free thyroxine in serum.


The specific immunoprecipitation of polyribosomes synthesizing an immunoglobulin light chain.


Diphtheria toxin and related proteins. I. Isolation and properties of mutant proteins serologically related to diphtheria toxin.


The mechanism of the antihypertensive action of  -methyldopa in hypertensive rats.


Lymphocyte heterogeneity and function.

Lymphocyte heterogeneity and function.


Diphtheria toxin and related proteins. II. Kinetic studies on intoxication of HeLa cells by diphtheria toxin and related proteins.


Diphtheria toxin and related proteins. 3. Reconstitution of hybrid "diphtheria toxin" from nontoxic mutant proteins.


Magnetic circular dichroism of cobalt-copper and zinc-copper bovine superoxide dismutase.


Transport of vitamin B 12  in Escherichia coli. Location and properties of the initial B 12 -binding site.


Combination of specific antibodies with the human vitamin A-transporting protein complex.


Aspergillus fumigatus in samples of moldy silage.


Oxidation of catechol in plants. IV. Purification and properties of the 3,4,3',4'-tetrahydroxydiphenyl-forming enzyme system from Tecoma leaves.


Basal body addition in ciliary rows of Tetrahymena pyriformis.


Tyrosine and catecholamine metabolism in wild-type Drosophila melanogaster and a mutant, ebony.


Radiologic seminar CXXVII: jejunal diverticulosis.


Lithium fluoride: an inexpensive calibration check for the general hospital.


The value of lumbar spinal tap in the diagnosis of closed head injury.


WHO Expert Committee on Rabies: sixth report.


Pharmacogenetics. Report of a WHO scientific group.


Reye syndrome. 3. The hypoglycemia.

Reye syndrome. 3. The hypoglycemia.


Megavoltage port radiography for therapy evaluation.


Infantile cirrhosis with hereditary alpha 1 -antitrypsin deficiency. Clinical improvement in two siblings.


Tuberculosis of the skin.

Tuberculosis of the skin.


Planning for dialysis and transplantation facilities.


The visual component in the courtship of Drosophila melanogaster.


Disappearance of radioactivity from plasma following intravenous administration of tritiated thyrotrophin-releasing hormone (Ro 8-6270) to man.


The ingestion of gonococci by epithelial cells.


Attachment of gonococci to the urethral mucosal cells of patients with gonorrhoea--a critical early stage in the pathogenesis of the infection?


The lipolytic activity of Micrococcaceae from human and animal sources.


Raised intracranial pressure and cerebral blood flow. 2. Supratentorial and infratentorial mass lesions in primates. Changes in cerebral blood flow with increasing intracranial pressure were studied in anaesthetized baboons during expansion of a subdural balloon in one of two different sites. With an infratentorial balloon, cerebral blood flow bore no clear relation to intracranial pressure, but was linearly related to cerebral perfusion pressure. Apart from an initial change in some animals, cerebrovascular resistance remained constant with increasing intracranial pressure, and autoregulation appeared to be lost from the outset. With a supratentorial balloon, cerebral blood flow remained constant as intracranial pressure was increased to levels around 60 mm Hg, corresponding to a cerebral perfusion pressure range of approximately 100 to 40 mmHg. Cerebrovascular resistance fell progressively, and autoregulation appeared to be effective during this phase. At higher intracranial pressure levels (lower cerebral perfusion pressure levels), autoregulation was lost and cerebral blood flow became directly dependent on cerebral perfusion pressure. The importance of the cause of the increase in intracranial pressure on the response of the cerebral circulation and the relevance of these findings to the clinical situation are discussed.


Outgrowth of Bacillus cereus spores harboring bacteriophage CP-51 DNA. I. Initiation of bacteriophage development. Time of initiation of bacteriophage CP-51 RNA synthesis, inhibition of host DNA synthesis, initiation of CP-51 DNA synthesis, and release of phage was determined in infected Bacillus cereus cells and outgrowing spores harboring phage DNA. The development of phage in outgrowing spores is initiated 45 min after induction of spore germination and then proceeds at a rate similar to that observed in infected cells. Although spore RNA synthesis is inhibited by the presence of chloramphenicol or puromycin during germination, these antibiotics do not inhibit initiation of phage DNA transcription in outgrowing spores.


Genetic study of suppressor-sensitive mutants of the Bacillus subtilis bacteriophage phi 29. With bacteriophage phi29 of Bacillus subtilis 133, suppressor-sensitive (sus) hydroxylamine mutants have been isolated. Intracistronic and intercistronic quantitative complementation placed the mutants in 13 cistrons, and three-factor crosses have been used to assign an unambiguous order for 10 cistrons. Recombination frequencies have been presented for several regions of the genome to facilitate comparison of the sus system with the previously published temperature-sensitive mapping systems.


Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses. Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses.


Protein differences associated with a phototransduction mutant of Drosophila.


Phencyclidine action on neural mechanisms of somesthesis.


Daily fetal movement recording and fetal prognosis.


Lecithin-sphingomyelin ratio and a rapid test for surfactant in amniotic fluid. A comparison.


Interocular transfer of reversed and nonreversed discrimination via the anterior commissure in monkeys.


Sexual behaviour of White Leghorn cocks bearing basal hypothalamic lesions in various locations.


A method for the construction and use of contact occluders for small animals.


Peripheral and central stimulus detection in auditory pathways of monkeys.


Diabetic keto-acidosis complicated by disseminated intravascular coagulation.


Gonococcal arthritis in pregnancy.

Gonococcal arthritis in pregnancy.


Anorectal gonorrhea presenting as ulcerative proctitis.


Colonization of burns by Streptococcus faecalis related to contaminated porcine xenografts.


Massive extracranial hematomas in two squirrel monkeys.


Canine alimentary neoplasia.

Canine alimentary neoplasia.


On the pharmacodynamics of Benzatcin.

On the pharmacodynamics of Benzatcin.


Tremor in diving.

Tremor in diving.


Effect of various microorganisms found in cosmetics on the normal and injured eye of the rabbit.


Conjunctivitis associated with Coxsackie B-1 virus in a laboratory worker.


Ocular and central nervous system findings in tetraploid-diploid mosaicism.


Repair after xenon arc photocoagulation. 3. An electron microscopic study of the evolution of retinal lesions in rhesus monkeys.


The phenogenetics of a super-suppressor in Drosophila melanogaster. II. Suppression and back-mutation.


Severe problems with gastric emptying after gastric surgery.


Deep freezing of boar semen. I. Effects of diluent composition, protective agents, and method of thawing on survival of spermatozoa.


Radioisotope-survey of metastases of breast carcinoma to bone using Sr-87m and whole body scanner.


An exo- -N-acetylglucosaminidase from Bacillus subtilis B; characterization.


Kinetic properties of microsomal UDP-glucuronyltransferase. Evidence for cooperative kinetics and activation by UDP-N-acetylglucosamine.


Differentiation of homologous forms of hepatic microsomal UDP-glucuronyltransferase. I. Evidence for the glucuronidation of o-aminophenol and p-nitrophenol by separate enzymes.


Differentiation of homologous forms of hepatic microsomal UDP-glucuronyltransferase. II. Characterization of the bilirubin conjugating form.


Adrenergic mechanism in Tetrahymena. I. Changes in monoamine oxidase activity during growth.


Storage of insecticides in the fat body of Spodoptera littoralis (Boisd.) as a possible mechanism of resistance.


Resistance to carbon dioxide, an anoxic stress in Drosophila melanogaster.


A study of the differentiation of bracts in Drosophila melanogaster using two mutations, H 2  and sv de .


Intracellular response by Tetrahymena pyriformis to fluids from unimmunized animals.


Mechanical factors in the design of chronic recording intracortical microelectrodes.


Immunochemical studies of two human liver carboxyl esterases.


The filtration coefficient of the intraocular vasculature as measured by low-pressure perfusion in a primate eye.


The effect of arterial PCO 2  on relative retinal blood flow in monkeys.


The intercellular junctional complexes of retinal pigment epithelia.


Effect of exogenous interferon on herpetic keratitis in rabbits and monkeys.


Gel filtration of thyroxine-binding proteins. Identification of rat plasma protein fractions separated on sephadex G-200.


Disodium cromoglycate.

Disodium cromoglycate.


Separation of NTA and EDTA chelates by thin-layer chromatography.


The hypothermic effect of tetrodotoxin in the unanaesthetized cat. 1. The hypothermic effect on unanaesthetized cats of tetrodotoxin injected I.V. or into the lateral cerebral ventricle was examined.2. At an ambient temperature (T(a)) of 22 degrees C, tetrodotoxin given intraventricularly was over 400 times more potent in lowering body temperature (T(b)) than when given I.V. The magnitude of the hypothermia was dose-dependent for both routes. Decreases in T(b) as great as 6.8 degrees C were induced by infusions or multiple injections of tetrodotoxin into the ventricle.3. Tetrodotoxin also lowered T(b) at T(a) = 13, 30 or 35 degrees C. Tachypnoea, which lasted for longer durations and which became more intense the higher the T(a), accompanied development of hypothermia. Shivering was observed only during recovery from hypothermia at 13 degrees C.4. During the tetrodotoxin-induced hypothermia, animals were still able to regulate against environmental thermal stresses.5. EDTA disodium salt, leucocytic pyrogen and prostaglandin E(1) antagonized the hypothermic effect of tetrodotoxin when they were administered during recovery from tetrodotoxin.6. Activation of heat-loss mechanisms, and the absence of compensatory shivering during development of hypothermia after tetrodotoxin administration, plus lowering of T(b) by tetrodotoxin at T(a) above as well as below the thermoneutral temperature, indicate that lowering of the thermoregulatory set-point is the mechanism by which centrally or peripherally administered tetrodotoxin lowers T(b). Further evidence for set-point lowering after intraventricular administration of tetrodotoxin is provided by persistence of the ability to regulate against both heat and cold stresses during hypothermia. The possibility that the decrease in set-point could be due to the well known action of tetrodotoxin to block transient increases in membrane sodium ion conductance is discussed in terms of a recent hypothesis regarding ionic control of the thermoregulatory set-point.


Scanning electron microscopy of the normal and BCG-stimulated primate respiratory tract.


Differential release of acetylcholine from the hypothalamus and mesencephalon of the monkey during regulation. 1. In unanaesthetized monkeys acclimated to primate chairs, 101 isolated sites in the hypothalamus and mesencephalon were perfused at a rate of 30-50 mul./min by means of push-pull cannulae. The perfusate, which contained an anticholinesterase, was assayed for acetylcholine (ACh) activity on the guinea-pig ileum in the presence of neostigmine.2. The body temperature of each animal was monitored continuously during an experiment by colonic and brain thermistors. To alter the ambient temperature by 15-20 degrees C, either a stream of warm air was passed over the monkey's trunk or containers of ice were placed in its chair chamber to cool the same region.3. Assays of the effluent revealed that the release of ACh varied according to the ambient temperature as follows: elevated only during cooling; elevated only during warming; elevated by both thermal stimuli; suppressed only by cooling; suppressed only by warming; suppressed by both thermal stimuli; elevated during cooling but suppressed by warming; and elevated by warming and suppressed by cooling.4. A composite anatomical ;mapping' of all perfusion sites revealed that in response to either peripheral cooling or warming, the output of ACh varied at only 36% of all sites anterior to the mid-hypothalamic plane, but at 65% of those loci caudal to this coronal plane.5. In the anterior, preoptic area, cooling enhanced the output of ACh at 88% of the active releasing sites, whereas warming reduced the release of ACh at 80% of these perfusion loci. Posterior to this region, ACh release was elevated by cooling at about half of the active releasing sites, but lowered by warming at nearly every active perfusion locus. Within the mesencephalon, the ratio of the temperature-induced change in ACh release was similar but in an opposite direction, since the level of ACh in the effluent collected from two out of three sites was augmented by cooling, but diminished by warming.6. These results provide additional evidence for the neurochemical model of Myers & Yaksh (1969), which suggests that a cholinergic pathway originating in the anterior, preoptic region transmits efferent signals for heat production. Further, within the posterior hypothalamic area as well as in the mesencephalon of the monkey, the characteristics of the ACh releasing sites reflect a function delegated primarily to heat gain, although evidence of a cholinergic pathway for the heat loss system is also presented.


Immunoglobulins as aspecific opsonins. 3. The opsonizing power of fragments of polyclonal and monoclonal immunoglobulin G.


The effect of lymphocyte supernatant fluids on the intracellular growth of virulent tubercle bacilli.


Lactase and other enzymes bound to a phenol-formaldehyde resin with glutaraldehyde.


An intravenous fat emulsion as a nitrogen sparer: comparison with lucose.


The induction by Listeria monocytogenes and plant mitogens of lymphocyte supernatant fluids which inhibit the growth of Mycobacterium tuberculosis within macrophages in vitro.


Technique of injection into the spinal cord of monkeys.


High voltage electron microscopy of the central nervous system in Golgi preparations.


Inhibition of collagen synthesis by the proline analogue cis-4-hydroxyproline.


The pathophysiology of irreversible hemorrhagic shock in monkeys.


The use of 7-chlorolincomycin in the treatment of childhood respiratory disease.


Aflatoxin B 1  producing potential of isolates of Aspergillus flavus Link ex Fries from cotton, maize and wheat.


Clinical and manometric effects of nitroglycerin in diffuse esophageal spasm.


Replacement therapy for inherited enzyme deficiency. Use of purified ceramidetrihexosidase in Fabry's disease.


The environmental causes of aggression.

The environmental causes of aggression.


Tuberculosis drug therapy. A review.

Tuberculosis drug therapy. A review.


The time course of preparatory processes in split-brain monkeys performing a variable foreperiod reaction time task.


Modifications in cortically-induced peripheral motor nerve activity induced by the center median in the cat and the squirrel monkey.


Urinary epinephrine and norepinephrine responses to chair restraint in the monkey.


The enhanced efficacy of disodium cromoglycate (DSCG) in DSCG predosed rats.


Serological responses of patas monkeys (Erythrocebus patas) to vaccination against cholera and yellow fever.


Vacuole formation in human erythrocyte ghosts.


The role of renal arteriography in pediatric hypertension.


Symposium on the role of heavy particle radiation in the treatment of cancer. Introduction.


Radiobiology of heavy particle radiation therapy: cellular studies.


High-LET radiation: clinical facilities available with neutron beams.


Pretherapeutic investigations with accelerated heavy ions.


A hospital-based superconducting accelerator facility for negative pi-meson beam radiotherapy.


Clinical dosimetry for negative pi mesons.


Preparation, physiology, and dosimetry of  111 In-labeled radiopharmaceuticals for cisternography.


Salivary IgA in periodontal disease.

Salivary IgA in periodontal disease.


A rapid mycobacterial drug susceptibility test.


Laboratory suggestions: a method for teaching the technic of electroimmunodiffusion for detection of the australia antigen and other proteins.


Letters to the editor: quantitation of cerebrospinal fluid proteins.


Tobramycin: bacteriological evaluation.

Tobramycin: bacteriological evaluation.


The effect of Pa CO2  on the metabolism of ischemic brain in squirrel monkeys.


Fat metabolism in higher plants. LV. Acetate uptake and accumulation by class I and II chloroplasts from Spinacia oleracea.


Choline sulfatase of Pseudomonas aeruginosa.


Long-term continuous exposure to sulfuric acid mist in cynomolgus monkeys and guinea pigs.


Fastigial nucleus connections to the septal region in monkey and cat: a demonstration with evoked potentials of a bilateral pathway.


Age effects of social behavior deficits following prefrontal lesions in monkeys.


Multiple coding of species-specific vocalizations in the auditory cortex of squirrel monkeys.


An ultrastructural study of the centre median and ventrolateral thalamic nuclei of the monkey.


An ultrastructural study of the termination of afferent fibres within the ventrolateral and centre median nuclei of the monkey thalamus.


The effect of prenatal malnutrition on dimensions of cerebral cortex.


The in vitro incorporation of ( 3 H)thymidine into DNA and of  32 P into phospholipids and RNA in the aorta of Rhesus monkeys during early atherogenesis.


Experimental immunization with attenuated mutants of Pseudomonas aeruginosa.


Autodegradation of RNA of bacterial ribosomes.


Corticosteroid ointments: comparison by two human bioassays.


Value of an acetaminophen-chlorzoxazone combination (parafon forte) in the treatment of acute musculoskeletal disorders.


Evaluation of a bacteriostatic soap, P-300, on skin flora of patients in protected environments.


A double-blind comparison of thioridazine (Mellaril) versus diazepam (valium) in patients with chronic mixed anxiety and depressive symptoms.


On the anti-anxiety properties of a new benzodiazepine, ORF 8063.


When to use cytotoxic drugs in rheumatoid arthritis.


Planning a treatment program for rheumatoid arthritis.


A contribution to the microbiology of urethritis.


A comparison between the clearances of inulin, endogenous creatinine and  51 Cr-EDTA.


Fluorescence histochemistry of monoamine-containing cell bodies in the brain stem of the squirrel monkey (Saimiri sciureus). I. The locus caeruleus.


Increased virulence of the E vaccine strain of Rickettsia prowazeki passaged in the lungs of white mice and guinea pigs.


Mechanisms in the suppression of delayed hypersensitivity in the guinea pig by 6-mercaptopurine. The mechanism of suppression, of delayed hypersensitivity to tuberculoprotein by 6-mercaptopurine (6-MP) was studied in guinea pigs. Under the conditions of the protocol, suppression of tuberculin delayed skin test reactivity was not associated with a significantly altered end-organ response to mediators of permeability. No significant alteration of in vivo lymphoid activity, as measured by reconstitution studies, was found. In addition, lymphoid cells from 6-MP-treated animals reacted in a fashion similar to those of placebo-treated animals with respect to (a) antigen-induced lymphocyte proliferation, (b) antigen-induced liberation of macrophage inhibitory factor activity, (c) direct inhibition by antigen of peritoneal exudate cell migration. Conversely, suppression was seen in levels of blood monocytes and in vitro function of macrophages from 6-MP-treated animals in several respects: (a) adherence to glass, (b) migratory rate, (c) phagocytic capacity. Therefore, it would appear that a ma]or mechanism of 6-MP-induced suppression of delayed hypersensitivity is through its action on effector cells.


Use of the microprecipitation method in agar gel (MPA) in the diagnostics of toxoplasmosis. 3. Correlation of MPA, complement-fixation reaction (CFT) and Sabin-Feldman's dye test (SFT) in serodiagnosis of human toxoplasmosis.


Hyaluronidase applied to the gingiva of rhesus monkeys.


Prevention of development of carriers in typhoid and paratyphoid fever.


International trends toward humanization of health services.


All volunteer: military medicine tomorrow.


Contraceptive steroids: modifications of carbohydrate and lipid metabolism.


Case for diagnosis.

Case for diagnosis.


PABA. A more effective sunscreen.

PABA. A more effective sunscreen.


A survey to assess potential human disease hazards along proposed sea level canal routes in Panama and Colombia. 3. Survey methods.


Patterns of illicit drug use in viral hepatitis patients.


Prognostic scales for personality disorders in the Naval Service.


Characteristics of naval recruits with histories of drug abuse.


The evolution of the support of medical research in the Veterans Administration.


Aflatoxicosis in the laying Japanese quail (Coturnix coturnix japonica).


Avian riboflavinuria. 8. The fate of the riboflavin-binding protein-riboflavin complex during incubation of hen's eggs.


Nonsusceptibility of some avian species to turkey leucocytozoon infection.


Extraction of calcium from blood fibrin with a solution of tetrasodium-ethylenediaminetetraacetate (Na4EDTA).


Thyroid metabolism of chickens. 1. Estimation of hormone concentration by the thyroxine binding globulin technique.


The nurse's role in parenteral hyperalimentation.


104 days with Rodney K.

104 days with Rodney K.


Dodecyldiaminoethyl glycine as an inhibitor of bacteria, fungi and dental plauqes.


Basic thalamic structure and function. Introductory remarks.


Some principles of organization in the dorsal lateral geniculate nucleus.


The medial geniculate body and associated thalamic cell groups: behavioral studies.


On the organisation of the visual cortical projection to the pulvinar in Macaca mulatta.


The connections of the dorsomedial nuclei.


Chemosterilization of the tropical house mosquito Culex pipiens fatigans Wied.: laboratory and field cage studies. Tris(1-aziridinyl)phosphine sulfide was found to be an excellent sterilant for male Culex pipiens fatigans. When male pupae were exposed to a 0.6% solution for 3 hours, the ensuing adults were rendered permanently sterile with no apparent reduction in their vigour or longevity based on laboratory and field cage studies. Females, however, exposed to the same dosage for the same length of time were partially fertile.


WHO cooperative studies on the phage-typing of mycobacteria. 1. Phage lysis of Czechoslovak and Italian strains of Mycobacterium tuberculosis. Although phage-typing of some pathogenic microbes-e.g., Escherichia coli and the genera Salmonella, Staphylococcus, and Streptomyces-is in routine use, little progress has yet been made in the phage-typing of mycobacteria, chiefly because mycobacteriophages possess a polyvalence that prevents the reliable identification of individual species of mycobacterium. Furthermore, laboratories cannot compare their results because they employ different methods and culture media and also because the phages used cannot be accurately identified. It has been shown that internationally reproducible results can be obtained for M. tuberculosis by selecting suitable mycobacteriophages and sensitive culture media, and by using a standardized technique of phage-typing. Under these conditions, phage lysis may be utilized to classify strains of M. tuberculosis.


Management and marketing in health care. Some lessons for the United States from the British system. The British health care system has been examined by sociologists, political scientists, and medical care specialists before, but in this presentation a section of the British health care system is viewed through the eyes of modern business management, particularly as to cost and consumer effectiveness. Examination of positive features as well as problems may be helpful in relation to some future health care delivery system in the United States. Cross fertilization between the disciplines of management and medicine has much to offer to the rapidly changing delivery of health care in the United States.


Human placental lactogen in high-risk pregnancy.


Effects of prenatal nutrition upon pregnancy risk.


Hemolytic disease.

Hemolytic disease.


Calories versus protein in children's nutrition.


Hemorrhagic disease due to vitamin K deficiency in a premature infant: a syndrome which may resemble disseminated intravascular coagulation (DIC).


Plumbism at the Green Parrot Goat Farm.

Plumbism at the Green Parrot Goat Farm.


Decreased performance behavior with carbaryl--an indication of clinical toxicity.


Comparative study of peroxidases from the thyroid and the submaxillary gland of goat (Ca pra hiscus).


Cell density as a selective parameter in Tetrahymena.


Comparative studies of anti-A agglutinins from various snails of the genus Helix (Helix pomatia and Helix aspersa).


Changes caused by air-drying and alcohol dehydration of spread insect sperm and fungal spore chromosome fibres.


Histochemical and biochemical studies on the localization and activity of lysosomal enzymes in fracture callus.


Occurrence of the genotype Cde-Cde in Papua New Guinea.


Present status and future problems of medical care in Japan.


Blood group genetic patterns and heterogeneity in New Guinea.


Purification and properties of pyocin S2.


Degenerative myelopathy in the aging German Shepherd dog: clinical and pathologic findings.


Immunological cross-reaction between thiol proteases of plant origin: stem and fruit bromelains.


Bioautography in paper and thin-layer chromatography and its scope in the antibiotic field.


Gonococcal septicemia.

Gonococcal septicemia.


A check-list of the species of the genus Leucocytozoon (Apicomplexa, Plasmodiidae).


The resorption of cilia in Cyathodinium piriforme.


East Coast fever of cattle:  60 Co irradiation of infective particles of Theileria parva.


Sublethal cytotoxic effects of mercuric chloride on the ciliate Tetrahymena pyriformis.


The conversion of phenylalanine to tyrosine in Tetrahymena pyriformis.


Changes in relative frequencies of behaviors in pigtail monkeys (Macaca nemistrina) following dorsolateral frontal ablations.


Influence of the implantation of Lactobacillus acidophilus in chicks on the growth, feed conversion, malabsorption of fats syndrome and intestinal flora.


The effects of N,N-dimethyltryptamine on operant behavior in squirrel monkeys.


Electron optical investigations on the morphological alterations produced by subacute sclerosing panencephalitis (SSPE) virus in Cercopithecus aethiops (R 6 CA) kidney cells.


Comparative investigations on immunodiffusion methods for detecting Australia antigen.


Technique for making evident the precipitation bands obtained in immunodiffusion reactions gel.


Sarcocystis in mice inoculated with toxoplasma-like oocysts from cat feces. Sarcocysts morphologically similar to Sarcocystis muris were observed in mice after inoculation with Toxoplasma-like oocysts found in feces of a stray cat. Cats that were fed mice infected with the oocysts shed similar oocysts in their feces. Sarcocysts were found histologically in about 50 percent of mice inoculated with 40,000 or more oocysts and examined 42 days or longer after exposure. Most inoculated mice developed low Toxoplasma dye-test antibody titers 3 to 4 weeks after exposure, but Toxoplasma antibody was usually not detectable in infected cats.


Hypothalamo-pituitary interrelationships in thyroid pathology, with special reference to cretinism.


Role of the placenta and of plasma hormone binding in the pathogenesis of cretinism.


Hypothalamic hypothyroidism: its possible relationshp to endemic goiter.


Alcohol preference.

Alcohol preference.


Studies of the development of alcohol addiction in infant monkeys.


Animal models of ethanol dependency.

Animal models of ethanol dependency.


The reinforcing property of ethanol in the rhesus monkey. I. Initiation, maintenance and termination of intravenous ethanol-reinforced responding.


Biochemical and metabolic aspects of alcoholism.


The affinity and temporal variation of isoelectric fractions of rabbit anti-lactose antibody.


Fatty acid synthetase activity in Euglena gracilis variety bacillarius. Characterization of an acyl carrier protein dependent system.


Stopped-flow studies of high pH activity and acetazolamide inhibition of bovine carbonic anhydrase. Enzyme-catalyzed hydrolyses of 3-pyridyl and nitro-3-pyridyl acetates.


Preoperative irradiation for osteogenic sarcoma.


The reaction of phenyl N-methylacetimidate with bovine serum albumin and bovine carbonic anhydrase.


Increased alkaline phosphatase in the tissues and hemolymph of the snail Biomphalaria glabrata infected with Schistosoma mansoni.


The complex of ATP-dependent deoxyribonuclease from Bacillus subtilis with DNA and its thermostability.


Preparation of mammalian gametes and reproductive tract tissues for scanning electron microscopy.


Carbon-13 nuclear magnetic resonance studies on thyrotropin-releasing factor and related peptides.


Lysis of lyophilized escherichia coli cells with egg-white lysozyme without ethylenediaminetetraacetic acid.


Triple massive-dose drug therapy in combined treatment of advanced ovarian carcinoma.


Development of a single, simple in vitro thyroid function test.


A method of correcting for collimator penetration by high energy gamma rays.


The distribution of l-thyroxine labeled with radioactive iodine-125 in the ears of squirrel monkeys.


The effects of antimalarial drugs on nucleic acid synthesis in vitro in Tetrahymena pyriformis.


Study of efficiency of some modifications of medium B-2 for the primary cultivation of tubercle bacteria.


Detection of vaccinia antigen and antibody by counterelectrophoresis.


[Diagnosis and therapy of pyelonephritis in various age groups].


Mitotic activity of peritoneum in contact with a regenerating area of peritoneum.


Variations in crypt cell cycle time and mitotic time in the small intestine of the rat.


The pars distalis of the pituitary as a source of liver growth stimulating factors during liver regeneration.


The influence of temperate bacteriophage phi105 on transformation and transfection in Bacillus subtilis.


Lactose synthetase in mammary gland of the California sea lion.


The optical rotatory properties of poly- -D-glutamic acid.


The effect of 2-mercaptoethanol (ME) and EDTA on the sub-species structure of horse liver alcohol dehydrogenase (LADH) in 8 M urea.


The psychiatric nonhospital: a model for change.


Conformational studies of anthrax polypeptide, subtilis polypeptide, and synthetic poly- -L-glutamic acid.


Control of pain and infection.

Control of pain and infection.


Storage iron kinetics. 3. Study of desferrioxamine action by selective radioiron labels of RE and parenchymal cells.


Brain cholesterol. XVI. Incorporation of different precursors into baboon tissue sterol.


Insulin response to intravenous alimentation.


Myocardial steal produced by coronary vasocilation in chronic coronary artery occlusion.


Hypothalamic hypopituitarism. A case of panhypopituitarism with TSH and LH deficiency of hypothalamic origin.


Cerebrospinal fluid transferrin II studies in ischemic disorders of the central nervous system.


Antibiotic stability in solutions used for intravenous nutrition and fluid therapy.


Successfully treated candida endophthalmitis in a child.


Mixed lymphocyte reactivity in rhesus sibships.


The efferent neural supply to the vertebrate ear.


Electrical activity of single auditory nerve fibers.


Noise-and drug-induced hearing loss in monkeys.


HOE 296, a new antimycotic compound with a broad antimicrobial spectrum. Laboratory results.


The synthesis and metabolic fate of  14 C-viminol, a new analgesic, in the rat and the dog.


Immobilized enzymes: the catalytic properties of lactate dehydrogenase convalently attached to glass beads.


Specific binding of ribonucleic acid by antiadenosine antibodies.


Plasmic degradation of human fibrinogen. II. Further characterization of fragment D.


Immunochemical studies on lactate dehydrogenase.


Stabilization of Bacillus subtilis  -amylase by amino group acylation.


"Photo-onycholysis" due to tetracycline.


GENERAL ASPECTS OF INFECTION CONTROL IN THE OPERATING ROOM AND INTENSIVE CARE UNIT.


New models in geriatrics and long-term care.


Federal government involvement in training medical directors of long-term care facilities.


Edema of the spinal cord following experimental impact trauma.


Experimental local thalamic application of xylocaine through silicone rubber chemode.


Localized renal parenchymal infections in children.


Milk-of-calcium in caliceal diverticulum.


A study on proteolytic oral microorganisms.


Metabolism of the hydroxyethylrutosides. Biliary and urinary excretion of 3',4',5-(hydroxyethyl- 14 C), 7-tetra-O-( -hydroxyethyl)-rutoside in rats and monkeys after parenteral administration.


Protection from exercise-induced asthma by pre-exercise cromolyn sodium and its relationship to serum IGE levels.


Thyrotropin releasing hormone: secretion and actions.


The purification and properties of an extracellular protease from Aspergillus oryzae NRRL 2160.


Iron binding of gastric mucins.

Iron binding of gastric mucins.


The unstable oblique distal fibular fracture.


Some biochemical properties of a cryomacroglobulin.


Nucleotide metabolism in the whole blood of various vertebrates: enzyme levels and the use of high pressure liquid chromatography for the determination of nucleotide patterns.


Clinical implications of Medicare upon an extended-care facility population.


Autologous tooth transplantations.

Autologous tooth transplantations.


Connecticut dentists' views on expanded duty dental auxiliaries--preliminary report.


Panoramic radiology--1973.

Panoramic radiology--1973.


Replantation case and technic.

Replantation case and technic.


What is our condition to be?

What is our condition to be?


A surgical approach to the problem lower denture.


Hydrotherapy in dentistry.

Hydrotherapy in dentistry.


Carbaryl synergism by substituted 1,3-benzodioxoles and related compounds and inhibition of mixed function oxidase.


The marmoset periodontium in health and disease.


Studies of the metabolism and distribution of prothrombin in healthy men with homologous  125 I-prothrombin.


The effect of several tissue thromboplastins on the activation of the abnormal factor X (factor X Friuli).


Identification of fibrinogen derivatives in plasma samples.


Measurement of fibrin proteolysis in vivo by a radioactive fibrin-millipore tube technique.


Use of antibody synergism to screen human multiparous sera for lymphocytotoxins.


Antisera to lysosomes. Effect on allograft rejection.


The rhesus monkey as a model for evaluation of the preservation of stored whole blood.


Selected types of frozen blood for patients with multiple blood group antibodies.


Hemolytic disease of the newborn due to anti-Js a .


A method for preservation of papainized and Rh-sensitized red cells.


Central venous alimentation.

Central venous alimentation.


A specific method for the quantitative determination of  -glucose-1-phosphate.


A compilation of amino acid analyses of proteins. IV. Residues per thousand residues series 1.


Precipitation of RNA, DNA, and nucleoprotein particles from very dilute solutions.


EDTA prevents the photocatalyzed destruction of the products of catecholamine oxidation.


Comparison of NCS solubilization and a wet combustion technique for  14 C measurement in dried biological tissues.


THR (lopremone): psychobiological responses of normal women. I. Subjective experiences.


Methaqualone withdrawal.

Methaqualone withdrawal.


THR (lopremone): psychobiological responses of normal women. II. Pituitary-thyroid responses.


Toxicological and teratological studies of 4((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)-1-piperazine ethanol hydrochloride (Tiaramide hydrochloride), an anti-inflammatory drug.


Kinetic properties of microsomal UDP-glucuronyltransferase. Regulation by metal ions.


Organelle formation in the presence of a protease inhibitor.


The use of buoyant density profiles in determining the length and spacing of repeated sequences in DNA.


Membrane proteins of Rhodopseudomonas spheroides. IV. Characterization of chromatophore proteins.


Uptake of calcium in chromaffin granules of bovine adrenal medulla stimulated in vitro.


Transcription of Tetrahymena mitochondrial DNA in vivo.


Presence of ergosterol in light-grown and dark-grown Euglena gracilis Z.


Diamine oxidase in rabbit liver. 1. Assay conditions and subcellular localization.


Diamine oxidase in rabbit liver. 2. Submicrosomal distribution.


Dna synthesis in isolated HeLa nuclei. A system for continuation of replication in vivo.


Studies for the effect of some dietary factors prevalent in the oasis on the rate of growth and serum protein fractions of experimental animals.


Luetic deafness.

Luetic deafness.


A model for experimental vasomotor rhinitis.


Independent control of ribosomal gene replication in polytene chromosomes of Drosophila melanogaster. The saturation values for ribosomal RNA hybridization have been determined for DNA from diploid and polytene tissues of Drosophila melanogaster. These values have been measured in XO and XX larvae which have, respectively, one and two nucleolus organizers in the diploid chromosome set. The results show that (1) in diploid cells the ribosomal (r)DNA is present in amounts proportional to the number of nucleolus organizers, (2) in polytene cells the rDNA is under-replicated with respect to the euchromatic DNA, and (3) in polytene cells the amount of rDNA is independent of the diploid number of nucleolus organizers. These observations suggest that somatic variations in rDNA content may involve independent polytenization of the nucleolus organizer without change in the number of ribosomal cistrons per organizer. The independent polytenization of rDNA is proposed as the chromosomal explanation for the relative increase in rDNA in flies of the XO constitution.