A rapid method for estimating microsomal oxidase activity in the housefly with (14C)parathion as substrate.


Immunoglobulin abnormalities in multiple sclerosis.


Levels of serum immunoglobulins in juvenile rheumatoid arthritis.


Similarities between the scrapie agent and the agent of the potato spindle tuber disease.


Longterm clinical study with glibenclamide.


Properties of SSPE virus; tissue culture and animal studies.


Isolation of Trypanosoma cruzi in an acutely infected patient.


Editorial: Of what measures are second generation suphonylureas?


Whole-body counting: analysis of retention data for isotopes having prominent fecal excretion.


A method for counting and concentrating living Trypanosoma cruzi in blood lysed with ammonium chloride.


Immunity to Eimeria maxima: reactions of antisera in vitro and protection in vivo.


Immunological and biochemical studies on fractionated bull spermatozoa.


Immunoglobulin levels in a laboratory-acquired case of human Chagas' disease.


Hematozoa from Colorado birds. IV. Galliformes.


Bacteriocinogeny in the Athiorhodaceae.

Bacteriocinogeny in the Athiorhodaceae.


A rapid method for the purification of immunoglobulin M (IgM) from the sera of certain mammalian species.


Low grade osteomyelitis of the jaws-with actinomycosis.


The radioallergosorbent test (RAST) in the diagnosis of atopic allergy.


Adhesion of dextran to Streptococcus mutans.


Evolution of reaginic antibodies in specific hyposensitization.


The relationship between blood coagulation and thrombosis and atherosclerosis in man, monkeys and carnivores.


The effect of molecular iodine on platelet aggregation in vitro.


Immunological studies on the blood coagulation Factor X and its warfarin-induced precursor.


Some serum globulin changes in East Coast fever.


Are all the Salmonella serological O factors polysaccharides?


The cytogenetic analysis of a fractured gene in Drosophila. The data presented in this study are derived from the analyses of Notch mutants known to be associated with visible cytological deficiencies. One mutant, Df(1)N(62b1), described as a right-side deficiency, bears a deletion that apparently initiates within the Notch locus and extends to the right as far as the locus of dm. Recombination experiments using heterozygotes of Df(1)N(62b1) with a series of intragenic point mutants within the Notch cistron suggest that this deficiency represents a deletion for the right-end portion of the gene. A consideration of the cytology of Df(1)N(62b1) supports the cytogenetic inference that, if a Notch locus-3C7 relationship is valid, the missing portion of the gene as assayed by recombination experiments has an interband position between 3C7 and 8.-The data derived from two left-side deficiencies with a genetic lesion in Notch and a deletion extending to w are somewhat equivocal, but they do support the presumed Notch locus-3C7 band relationship and thereby enhance the likelihood that Df(1)N(62b1) is correctly interpreted.-Cytogenetic information presently available suggests that, although a significant portion of the Notch cistron has a position on the salivary map identified as interband 3C7 to 8, the 3C7 band is part of the total picture of the Notch gene.


Protein-calorie malnutrition diagnosis by hair tissue: a review.


A porcine immunoglobulin Fcmu polymer that has no J chain.


The subcellular distribution of 14C-glibenclamide in different tissues of rat.


Characterization of the selenium in rat liver mitochondria as glutathione peroxidase.


Purification of a hemagglutinin from Limulus polyphemus by affinity chromatography.


A note on the use of reduced transport fluid (RTF) for isolation of Neisseria gonorrhoeae.


Susceptibility of mucoid Pseudomonas aeruginosa to gentamicin disks.


Letter: Somatostatin action on pancreas.


The radiologist in prevention and diagnosis of instrumental perforation of the esophagus.


The alcohol dehydrogenases of Drosophila melanogaster: frequency changes associated with heat and cold shock. Laboratory populations of Drosophila melanogaster were subjected to heat and cold shock of sufficient duration and intensity to cause about 90 percent mortality. Alcohol dehydrogenase phenotypes were determined in survivors and controls. Significant changes in phenotypic frequencies occurred as a result of both treatments such that relative fitness appeared to be dependent on temperature. The alcohol dehydrogenase phenotype most frequently surviving heat under laboratory conditions is the same phenotype as that previously found to be higher in frequency in natural populations in areas with higher average temperature.


Intracellular proteolytic activity in developing myxospores of Myxococcus xanthus.


Hematozoa of passeriform birds from insular Newfoundland.


Fissure sealants. Laboratory studies.

Fissure sealants. Laboratory studies.


Blood groups in Zambia.

Blood groups in Zambia.


Population studies on the Aland Islands. II. Historical population structure: inference from bioassay of kinship and migration.


The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor.


Identification of the structural gene of levansucrase in Bacillus subtilis Marburg.


Specific recognition in gene conversion. The extent of repair synthesis in SPP1 transfection of B. subtilis.


A technique for isolating the enamel organ of the rat incisor for histologic studies.


Experimental study on fractures of the mandibular condylar process (mandibular condylar process fractures).


Closed condylotomy in the treatment of osteoarthritis of the temporomandibular joint.


A histologic study of experimentally induced periapical inflammation in primary teeth in monkeys.


Treatment of oroantral communication.

Treatment of oroantral communication.


Absorbable synthetic suture material for internal fixation of fractures of the mandible.


Aspiration cytology in the diagnosis of orofacial masses.


An improved high-level whole-body counter.


Cellular necrosis model in tissue culture: uptake of 99mTc-tetracycline and the pertechnetate ion.


Iron hydroxide particle retention in primate lungs.


Orosomucoid content of pleural and peritoneal effusions. 22 nonneoplastic, noninflammatory effusions (cirrhosis and congestive heart failure), 12 non-neoplastic inflammatory effusions (tuberculosis, lupus erythematosus, rheumatoid arthritis, and idiopathic pleuropericarditis), and 58 neoplastic effusions (cancer of lung, breast, ovary, and pancreas, and lymphoma) were analyzed by radial immunodiffusion for orosomucoid concentration. The average concentration +/-SE was 35+/-4, 65+/-17, and 130+/-13 mg/100 ml in the three types of effusion, respectively. By gel filtration and ion exchange chromatography, orosomucoid was isolated from 12 nonmalignant and 14 malignant fluids. The orosomucoid preparations reacted as single components in acrylamide gel electrophoresis at pH 9.0, and in immunodiffusion and immunoelectrophoresis against antisera to human serum and to human plasma orosomucoid. In radial immunodiffusion, the slope of the line relating concentration to the square of the diameter of the precipitate area was identical for orosomucoid isolated from normal human plasma and from nonneoplastic effusions, but was subnormal for orosomucoid isolated from neoplastic fluids. All orosomucoid preparations had normal amino acid composition. Orosomucoid from the nonmalignant effusions had normal carbohydrate content. 11 of 14 samples of orosomucoid isolated from neoplastic fluids had abnormalities in carbohydrate composition, consisting of subnormal content of sialic acid (11 of 14), hexose (10 of 14), and hexosamine (3 of 14), and abnormally high content of hexosamine (4 of 14). Discriminant analysis showed that concentration of orosomucoid distinguished between neoplastic and nonneoplastic noninflammatory effusions more effectively than concentration of total protein, albumin, alpha(1), alpha(2), beta, or gamma-globulin.


Multiple complications and death following protriptyline overdose.


Clorazepate dipotassium in the treatment of intractable epilepsy.


Autotransfusion in the subhuman primate.


Surgical management of perforated duodenal diverticula.


Nonoperative roentgenologic instrumentation technics of the postoperative biliary tract. Treatment of biliary stricture and retained stones.


Nitrogen and amino acid metabolism in adults with protein-calorie malnutrition.


[Repeat intervention of the biliary tract from the internistic viewpoint].


An electron microscopic study of the intracellular development of echovirus 22.


Studies on the mechanisms of influenza virus infection in hamster trachea organ culture. Correlation of reduced viral adsorption with age-related resistance to infection.


Comparison of maternal and cord serum titres for measles and for rubella antibodies.


Bovine respiratory syncytial virus: host range in laboratory animals and cell cultures.


Enzymic properties of diamine oxidase from hog kidney.


Impairments in primate information processing resulting from nitrogen narcosis.


Hippocampal, hypothalamic and lateral geniculate activity during visual discrimination in the monkey.


Cell mediated lympholysis in man. A case of "non relevant" killing of third party persons.


Carbonic anhydrase activity in the saliva of children and its relation to caries activity.


Nasal congestion as a side effect of cromolyn sodium.


Thyrotropin-releasing hormone in chicks.


Letter: Replacement treatment of hypothyroidism.


Stabilization and activation of a human glucose-6-phosphate dehydrogenase variant with enzyme deficiency by specific antibody.


[The antibacterial activity of thyme and wild thyme oils].


Iodometric determination of penicillins using iodine monochloride.


Fine structure of Haemoproteus columbae Kruse during macrogametogenesis and fertilization.


Intestinal parasite survey of kindergarten children in New Orleans.


Recent advances in the pathophysiology of the parathyroid glands.


Chemotaxis toward amino acids in Bacillus subtilis.


Conjugation and phage MS 2 infection with Hfr Escherichia coli.


Molecular heterogeneity of the bdellovibrios: metallo and serine proteases unique to each species.


Autolytic activity associated with myxospore formation in Myxococcus xanthus.


Algicidal effect of 2,4-dichlorophenoxy acetic acid on blue-green alga Cylindrospermum sp.


Selective inhibition of plasmid DNA production in Bacillus megaterium by 6-(p-hydroxy-phenylazo)-uracil: evidence for multiple maintenance systems.


Proceedings: Effects of PCB administration on two generations and its chronic toxicity on the third generation in mice. 2.


Proceedings: Mechanism of action of circulatory drugs with regard to effects on venous return. 2.


Prevention of tuberculous cavity formation by desensitization with tuberculin-active peptide.


Hypersensitivity lung disease in the turkey raising industry.


Extrinsic allergic alveolitis owing to hypersensitivity to chickens-significance of sputum precipitins.


Ontogeny of Tamm-Horsfall urinary glycoprotein.


Serum proteins and alkaline phosphatase levels in patients with tuberous sclerosis.


A calorimetric study of the binding of sulfonamides and cyanate to carbonic anhydrase.


Hemoglobin S-Ga Georgia disease: a case report.


Letter: Intrathoracic foregut cysts.

Letter: Intrathoracic foregut cysts.


Sodium valproate in treatment of epilepsy. Sodium valproate has a simple chemical structure unlike other anticonvulsants. It has been given to 63 patients with various types of epilepsy whose attacks were frequent and of whom 40 had failed to respond to other anticonvulsants. Fits stopped completely in 27 patients (43%) and 14 (22%) showed a reduction of attacks by more than 50%. The best results were in patients with absences (typical and atypical) associated with spike and wave discharges on the electroencephalogram. Myoclonic epilepsies responded well and improvement occurred with tonic-clonic seizures and focal motor fits. There was little or no improvement in temporal lobe epilepsy. Sodium valproate given alone did not cause unwanted effects but it potentiated many other anticonvulsants. An unusual side effect was temporary hair loss. A number of patients became more alert, school performances improved, and the management of subnormal patients became easier.


Influence of local hydrophobic environment on acid dissociation constants of coordinated water molecules.


Immune damage to liposomes containing lipids from Schistosoma mansoni worms.


Measurement of posture in japanese monkey (Macaca fuscata) by telemetry.


Mutagenicity testing of cyclamate and some pesticides in Drosophila melanogaster.


Comparative characterization of microbiological and biological assays of protein quality of some foodstuffs.


Amylase content of mixed saliva in children.


Malignant external otitis and facial paralysis.


Serum IgE levels in individuals infected with Schistosoma mansoni and Schistosoma haematobium.


Animal atmospheric exposure chamber system using a modified tank respirator.


Gonorrhea.

Gonorrhea.


The IUD and prostaglandins: a review of the evidence.


Microbial production of cobalamin (vitamin B 12).


Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Various species of Streptomyces possess aminoglycoside-modifying enzymes. Streptomyces kanamyceticus contains an enzyme that acetylates the 6'-amino group of kanamycin A and B, gentamicin C(1a), and neomycin. Streptomyces spectabilis produces an enzyme that acetylates the 2'-amino group of the hexose ring of gentamicin C(1a). These enzymes catalyze reactions identical to those catalyzed by enzymes found in gram-negative bacteria containing R(antibiotic resistance)-factors. The discovery of these enzymes suggests the possibility of an evolutionary relationship between the aminoglycosideinactivating enzymes (produced by resistance determinants) in bacteria containing R-factors and similar enzymes found in the actinomycetes.


Methyldopa: physicochemical characterization of the erythrocyte autoantibody.


The etiology and implications of lactose intolerance.


An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.


Galvanic skin responses (GSR) and plethysmographic changes induced by chlorimipramine, imipramine and placebo.


Physical compatibility and chemical stability of cephapirin sodium in combination with non-antibiotic drugs in large-volume parenteral solutions. II.


The ultrastructure of the rat renal medulla as observed after improved fixation methods.


Activity of BB-K8 (amikacin) against clinical isolates resistant to one or more aminoglycoside antibiotics. One hundred fifty-two bacterial strains that possess resistance to kanamycin A, gentamicin, or tobramycin, or to more than one of these antibiotics, were collected from various sources in Canada, Europe, Japan, and the United States. This collection was composed of Staphylococcus aureus and Pseudomonas aeruginosa and members of the Enterobacteriaceae family. Their susceptibility to BB-K8 (amikacin), a new broad-spectrum semisynthetic derivative of kanamycin A, and to the other agents, was determined on Mueller-Hinton Medium by the twofold agar dilution method. Test results revealed that 60.5% of the isolates were resistant to 8 mug of tobramycin per ml, 67.1% to 8 mug of gentamicin per ml, 86.2% to 20 mug of kanamycin A per ml, and only 8.6% to 20 mug of amikacin per ml. Of interest is the fact that the amikacin-resistant strains were generally resistant to all of the other aminoglycosides. The broad spectrum of amikacin was not totally unexpected, because the compound has been shown to be a poor substrate for most enzymes that inactivate other aminoglycosides through O-phosphorylation, O-adenylylation, or N-acetylation. A number of susceptibility profiles were obtained when the organisms were tested against a series of nine aminoglycosides. The majority of these profiles resembled those found for organisms that possess known mechanisms of enzymatic inactivation.


Editorial: Familial medullary carcinoma of the thyroid.


Biliary magnesium loss in the postoperative patient.


Cell death and autonomous gene action in lethals affecting imaginal discs in Drosophila melanogaster.


Biological properties of macarbomycin, an antibiotic containing phosphorus.


Letter: Four minor antibiotics from macarbomycins.


EM49, a new peptide antibiotic. I. Fermentation, isolation, and preliminary characterization.


Letter: Synthesis of (S)-4-amino-2-hydroxybutyryl derivatives of 3',4'-dideoxykanamycin B and their antibacterial activities.


Sarcoidal reactions in animals intensively immunized with tetanus vaccine.


Two types of melanogenesis in monolayer cultures of melanoma cells.


Effects of 2,4-dinitrophenol and dinactin on heat-sensitive and ecdysone-specific puffs of Drosophila salivary gland chromosomes in vitro.


Antigenic differences between normal mouse epidermis and methylcholanthrene-induced squamous-cell carcinomas.


Long-term management of airway secretions and bronchospasm in chronic obstructive lung disease.


Transient peripheral plasmacytosis.

Transient peripheral plasmacytosis.


Isolation and in vitro cultivation of the mammalian microsporidian Encephalitozoon cuniculi.


Early appearance and regional differences in intraneuronal and extraneuronal lipofuscin accumulation with age in the brain of a nonhuman primate (Macaca mulatta).


Bone mineral content of the femoral neck after irradiation.


Evaluation of bladder diverticulum using fiberoptic bronchoscope.


Problems in the extraction DNA when utilizing pancreatic RNAase and pronase.


Properties and function of the pyruvate: ferredoxin oxidoreductase from the blue-green alga Anabaena cylindrica.


The effects of protein synthesis-inhibiting antibiotics on the puffing pattern of Drosophila salivary gland chromosomes in vitro.


Population mean marrow dose and leukaemia significant dose from beam-therapy in Japan, 1971.


The anatomical basis of prosopagnosia.

The anatomical basis of prosopagnosia. Evidence is presented that patients with prosopagnosia have right anterior inferior occipital lesions in the region of the occipital temporal junction. Many if not all cases have an additional lesion in the left hemisphere; this is often but apparently not always symmetrical with the right hemisphere lesion. This evidence is discussed in relation to the anatomical connections of these regions and the results of experiments in animals.


Isozymes of lysozyme in leukocytes and egg white: evidence for the species-specific control of egg-white lysozyme synthesis. Two structurally distinct forms of eggwhite lysozyme (EC 3.2.1.17) are known. The egg white of some species contains both of these forms, while the egg white of other species appears to contain only one or the other of them. We have immunological and electrophoretic evidence that the chicken, which has only one lysozyme type in its egg white, contains both types in its polymorphonuclear leukocytes. Experiments on Embden goose bone marrow showed that this tissue also contains both lysozymes, even though the egg white of this species contains only one of them. Our studies suggest that many avian species have the genetic loci that code for both forms of lysozyme, but that a species-specific regulatory mechanism controls whether one or the other or both of them are expressed during egg white production. The fact that two distinct lysozymes are present in chicken leukocytes may be of significance to the antibacterial mechanism of these cells, especially in light of the fact that they lack myeloperoxidase, an important leukocyte enzyme in mammals.


The activity-related ionization in carbonic anhydrase. The catalytic activity of carbonic anhydrase (EC 4.2.1.1) is linked to the ionization of a group in close proximity to the essential zinc ion. Studies have been undertaken to delineate the ionizations germane to the active-site chelate system. Several imidazole ligand systems were studied in order to approach a representative chelate. The simplest involved the complexation of Zn(II) by imidazole and by N-methylimidazole. As well, two bidentate systems, Zn(II)-4,4'-bis-imidazoylmethane and Co(II)-cyclic-L-histidyl-L-histidine were investigated. It was found that in a species containing metal-bound water and imidazole coordinated by means of the pyridinium nitrogen, the most acidic group was the pyrrole N-H in the imidazole ring. By the use of N-methylimidazole, the pK(a) of a metal-bound water molecule in a tri-imidazole ligand field was found to be 9.1. Noting the preference for labilization of the pyrrole hydrogen, the catalytic features of carbonic anhydrase are reexamined assuming that the pK(enz) is associated with the N-H ionization, and not with the ionization of metal-bound water.


Viral infections of the fetus.

Viral infections of the fetus.


Serum and cerebrospinal fluid magnesium and calcium contents in idiopathic grandmal epilepsy.


An introduction to principles of veterinary clinical pharmacology: the elimination of drugs. 1. Rate of drug elimination.


Manifestations of copper deficiency in a patient with systemic sclerosis on intravenous hyperalimentation.


Blood viscosity in Waldenström's macroglobulinemia.


Biochemical and genetic studies in two families with Fabry disease.


Scanning electron microscopy in the ultrastructural analysis of the mammalian cerebral ventricular system.


Renal tubular antigen excretion in normal human urine. I. Immunochemical indentification.


New attachment after treatment of intrabony defects in monkeys.


Selective release of content from microsomal vesicles without membrane disassembly. II. Electrophoretic and immunological characterization of microsomal subfractions. Rough and smooth microsomes were shown to have similar sets of polypeptide chains except for the proteins of ribosomes bound to the rough endoplasmic reticulum (ER). More than 50 species of polypeptides were detected by acrylamide gel electrophoresis, ranging in molecular weight from 10,000 to approximately 200,000 daltons. The content of rough and smooth microsomes was separated from the membrane vesicles using sublytic concentrations of detergents and differential centrifugation. A specific subset of proteins which consisted of approximately 25 polypeptides was characteristic of the microsomal content. Some of these proteins showed high rates of in vivo incorporation of radioactive leucine or glucosamine, but several others incorporated only low levels of radioactivity within short labeling intervals and appeared to be long-term residents of the lumen of the ER. Seven polypeptides in the content subfractions, including serum albumin, contained almost 50% of the leucine radioactivity incorporated during 5 min and cross-reacted with antiserum against rat serum. Almost all microsomal glycoproteins were at least partly released with the microsomal content. Smooth microsomes contained higher levels of albumin than rough microsomes, but after short times of labeling with [(3)H]leucine the specific activity of albumin in the latter was higher, supporting the notion that newly synthesized serum proteins are transferred from rough to smooth portions of the ER. On the other hand, after labeling for 30 min with [(3)H]glucosamine, smooth microsomes contained higher levels of radioactivity than rough microsomes. This would be expected if glycosidation of newly synthesized polypeptides proceeds during their transit through ER cisternae. The labeling pattern of membrane proteins in microsomes obtained from animals which received three daily injections of [(3)H]leucine, the last administered 1 day before sacrifice, followed the intensity of bands stained with Coomassie blue, with a main radioactive peak corresponding to cytochrome P 450. After the long-term labeling procedure most content proteins had low levels of radioactivity; this was especially true of serum proteins which were highly labeled after 30 min.


Antibody-mediated effects on the periodontium.


Reversible, thermotropic alteration of nuclear membrane stucture and nucleocytoplasmic RNA transport in Tetrahymena. We examine the effect of cooling upon the freeze-etch ultrastructure of nuclear membranes, as well as upon nucleocytoplasmic RNA transport in the unicellular eukaryote Tetrahymena pyriformis. Chilling produces smooth, particle-free areas on both faces of the two freeze-fractured macronuclear membranes. Upon return to optimum growth temperature the membrane-associated particles revert to their normal uniform distribution and the smooth areas disappear. Chilling lowers the incorporation of [(14)C]uridine into whole cells and their cytoplasmic RNA. Cooling from the optimum growth temperature of 28 degrees to 18 degrees C (or above) decreases [(14)C]uridine incorporation into cells more than into their cytoplasmic RNA; chilling to below 18 degrees C but above 10 degrees C causes the reverse. [(14)C]Uridine incorporation into whole cells and their cytoplasmic RNA reflects overall RNA synthesis and nucleocytoplasmic RNA transport, respectively. RNA transport decreases strongly between 20 degrees and 16 degrees C, which is also the temperature range where morphologically detectable nuclear membrane transitions occur. This suggests that the nuclear envelope limits the rate of nucleocytoplasmic RNA transport at low temperatures. We hypothesize that a thermotropic lipid phase transition switches nuclear pore complexes from an "open" to a "closed" state with respect to nucleocytoplasmic RNA transport.


Osseous grafts and implants in the restoration of large oral defects.


In vitro and in vivo activity of certain thiosemicarbazones against Trypanosoma cruzi.


Amine functions of reduced basicity. Hypoglycemic and natriuretic alpha-alkoxybenzylamidoximes, amidines, and cycloamidines.


Comparison of culture-induced, phenobarbital-induced and naturally-developing UDP-glucuronyltransferase.


Nature of residual erythrocyte catalase activity in Swiss-type acatalasemia.


Migration of mast cells through the area postrema.


A rapid technique for separation of thymocytes from suspensions by centrifugation through silicone oil.


Electron microscopic autoradiographic study of cholesteral passage across arterial and capillary endothelium.


Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin.


A woman with multiple congenital anomalies, mental retardation and mosaicism for an unusual translocation chromosome t(6;19).


Partial trisomy 13 in a case of Cyclopia with 13-14 translocation.


Factors involved in the production of amblyopia.


Ruptured cervical aneurysm with neurofibromatosis.


Cutis verticis gyrata and the Lennox syndrome.


Cerebral degenerative disorders of infancy and childhood.


Endogenous glyceride synthesis rate in baboons fed diets containing sucrose or glucose.


Lymphoma in owl monkeys (Aotus trivirgatus) inoculated with Herpesvirus saimiri: clinical, hematologic and pathologic findings.


Recognition impaired and association intact in the memory of monkeys after transection of the fornix.


A non-modality specific impairment in spatial learning after fornix lesions in monkeys.


Specialization of the left hemisphere in baboon-evidence from directional preferences.


Segmental middle cerebral artery occlusion in primates: an experimental method requiring minimal surgery and anesthesia.


The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: an experimental study by the technique of hydrogen clearance in baboons.


The amino acid sequence of streptomyces griseus trypsin. II; The tryptic peptides.


Animal DNA-dependent RNA polymerases. Molecular structures and immunological properties of calf-thymus enzyme AI and of calf-thymus and rat-liver enzymes B.


An immunological investigation of the structure and function of ribulose 1,5-bisphosphate carboxylase.


Isolation of carbonic anhydrase from dog erythrocytes and determination of its N-terminal amino-acid sequence.


Editorial: Diabetes in the young.

Editorial: Diabetes in the young.


Recent advances in surgery of the brain. Dr. P. Kutumbiah endowment lecture--1971.


Place of the anesthetist in the intensive care unit.


Coccidia of the cotton rat, Sigmodon hispidus, from Alabama.


Mandibular joint involvement in a case of Fanconi's syndrome with renal failure.


Use of parenteral hyperalimentation in treatment of alkaline reflux gastritis.


Coeliac disease. Barium studies.

Coeliac disease. Barium studies.


Unusual spondyloepiphyseal and spondylometaphyseal dysplasias of childhood.


The blockade of the local generation of prostaglandins explains the analgesic action of aspirin.


Effects of puff-adder venom on coagulation, fibrinolysis and platelet aggregation in the baboon.


Transferable resistance to carbenicillin and gentamicin in Pseudomonas aeruginosa.


The clinical usefulness of C-reactive protein (CRP) determinations in bacterial meningitis and septicemia in infancy.


Detection of biological false positive syphilis serum reactions.


A carbenicillin R factor from Pseudomonas aeruginosa.


Combined action of sulbenicillin and gentamicin.


Epiphyseal injuries.

Epiphyseal injuries.


The child who convulses with fever.

The child who convulses with fever.


Pediatric surgery. Current concepts.

Pediatric surgery. Current concepts.


Normal serum triiodothyronine concentration and the lack of TSH response to TRH in patients with euthyroid Graves' disease.


Viral and non-viral properties of the scrapie agent.


Fluorescein angiography of the glaucomatous disc.


Kuru and Creutzfeldt-Jakob disease. Experimental models of noninflammatory degenerative slow virus disease of the central nervous system.


Enhancement of baboon liver allografts with noncytotoxic preparations of alloimmune IgG.


Antimacaque thymocyte globulins. Toxicity and immunodepressive effect in the human species.


Genetic transformation of the blue-green bacterium, Anacystis nidulans.


Food preservation and antibacterial properties of four fluoroalkane compounds.


Human antibody response to group A streptococcal teichoic acid.


Prolactin and thyrotropin in thyroid diseases: lack of evidence for a physiological role of thyrotropin-releasing hormone in the regulation of prolactin secretion.


Vertebral epidermal transamidases.

Vertebral epidermal transamidases.


Relative rates of transcapillary movement of free thyroxine, protein-bound thyroxine, thyroxine-binding proteins, and albumin. The rate of appearance of labeled thyroxine (T4) and albumin in lymph from various areas after simultaneous i.v. injection of the labeled substances in conscious ambulatory sheep has been used to estimate the relative rates of transcapillary movement of stable T4 and albumin. Labeled T4 appeared in hepatic lymph at the same rate as albumin. In intestinal and leg lymph, labeled T4 appeared eight and four times as rapidly as albumin indicating that T4 crosses capillaries in these areas independently of and much more rapidly than albumin and other proteins having similar distribution kinetics. The lymph:plasma ratios for all the T4-binding proteins including albumin were very similar in any one area showing that the relative fractional rates of transcapillary movement of these proteins were very similar. Therefore in extrahepatic areas, transcapillary movement of T4 in the protein-bound form was quantitatively much less important than in the free form. The findings support earlier views, recently questioned, that free T4 is of considerable physiological significance.


Poly-DL-alanyl skin isograft rejection by purified anti-poly-DL-alanyl antibodies.


Interaction between an R factor and an element conferring resistance to mercuric ions in Pseudomonas aeruginosa.


X-ray induced mitotic recombination in Drosophila melanogaster. 3. Dose dependence of the "pairing" component.


Direct assay for sigma factor activity and demonstration of the loss of this activity during sporulation in Bacillus subtilis.


Phenotypic properties of Bacillus subtilis mutants defective in recombination and repair functions.


The ribosomal proteins of Drosophila melanogaster. 3. Further studies on the ribosomal protein composition during development.


Actions of chinoform and oxine on the isolated phrenic nerve-diaphragm preparation of the rat: the accumulation of chinoform by rat diaphragm strip.


A "double-blind" trial of disodium cromoglycate in Thai asthmatic children.


Interferon production by simian lymphoblastoid cell lines.


Cerebral infarction. Evolution of histopathological changes after occlusion of a middle cerebral artery in primates.


The induction of a fatal desmoplastic mesothelial reaction in rabbits with mouse Ehrlich ascites carcinomata.


Induction of autoallergic gastritis in dogs.


Clinical and hormonal response to bromocriptin (CB-154) in the galactorrhea syndromes.


Growth hormone in adults with protein-calorie malnutrition.


Immunochemical quantitation of human transcortin.


Thyroxine-binding globulin in infant protein-calorie malnutrition.


Nanophyetus salmincola infections in kippered salmon.


Carcinoma of the cervix: establishment of a hyperbaric oxygen trial associated with the use of the cathetron.


Nitroglycerin to unmask reversible asynergy. Correlation with post coronary bypass ventriculography.


The development of the macronucleus in the ciliated protozoan Stylonychia mytilus.


Computerized intravenous glybenclamide test in early diagnosis of diabetes mellitus.


In vitro secretion of insulin after glucose, sulphonylureas, adrenergic and cholinergic substances studied by isolated perfused rat pancreas.


Letter: Development of gelatin-urease films.


Simplified water-loading test in bacteriuria.


Response of units in striate cortex of squirrel monkeys to visual and electrical stimuli.


Effects of dentate cooling on rapid alternating arm movements.


Cross-reactivity of monkey pituitary extracts in human radioimmunoassays.


Effect of exogenous estradiol-17 beta on vitellogenic oocyte growth in ovaries of the toad Bufo bufo bufo (L.) during the postspawning period.


Variations in plasma amino acid concentrations after abdominal surgical procedures.


Investigations on some physico-chemical and immunological properties of viral hepatitis antigen (HB Ag).


Brain growth in children with marasmus. A study using head circumference measurement, transillumination and ultrasonic echo ventriculography.


Intra-abdominal vascular complications of diabetic ketosis.


Carcino--embryonic antigen and its significance.


Effect of palatoplasty and cleft extent on facial and dental relations.


Factors affecting fluid movement and intercellular space formation in the toad bladder.


Inhibition of inter-microbial predation by chlorinated hydrocarbons.


Effect of beta-N-oxalyl-L-alpha, beta-diaminopropionic acid on glutamate uptake by synaptosomes.


Coronary bypass grafts.

Coronary bypass grafts.


Endarterectomy in surgical treatment of coronary disease.


Eradication of carriage of Neisseria meningitidis in families: a study in Brazil.


The human fallopian tube: a laboratory model for gonococcal infection.


Comparison of three agents of acute infectious nonbacterial gastroenteritis by cross-challenge in volunteers.


Gas chromatography as a potential means of diagnosing arthritis. I. Differentiation between staphylococcal, streptococcal, gonococcal, and traumatic arthritis.


Transmission of rat virus in milk of rats.


Studies with (plus)--octanoylcarnitine in experimental diabetic ketoacidosis.


Absorption of amino acids in malnourished rats.


Hypergraphia in temporal lobe epilepsy.

Hypergraphia in temporal lobe epilepsy.


Furosemide and pentobarbital in cryogenic cerebral injury and edema.


Intraluminal duodenal diverticulum. A rare cause of acute pancreatitis.


Fusion of the scoliotic spine in young children.


The role of genetic balance in control of transcription rate in the X-chromosomes of Drosophila melanogaster.


Mitosis-like macronuclear division in a ciliate.


The histones of the ciliated protozoan Stylonychia mytilus.


Leukocyte antigens of primates.

Leukocyte antigens of primates.


Children with protein-calorie malnutrition evacuated to Gabon during the Nigerian civil war.


Teaching better nutrition by domiciliary management of cases of protein calorie malnutrition in rural areas (a longitudinal study of clinical and economical aspects).


Depression of immunity in protein-calorie malnutrition: a post-mortem study.


Lead poisoning. Current status of the problem facing pediatricians.


Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins.


The EEC syndrome.

The EEC syndrome.


Letter: Random deviations or asynchronous DNA synthesis?


Reduced susceptibility to scrapie in mice after steroid administration.


Dominance and sexual behavior: a hypothesis.


The action of protein synthesis inhibitors and thyrotropin releasing factor on the ultrastructure of rat thyrotrophs.


Accurate office diagnosis of vaginitis.

Accurate office diagnosis of vaginitis.


Ultrastructural changes in the bacterial vegetative endocarditis.


Proceedings: Overview of the mammary gland.


Proceedings: The mammary glands of rhesus monkeys.


Recovery of Neisseria meningitidis from the nasopharynx. Comparison of two techniques.


Proceedings: Neuroendocrinology of lactation.


Oculodentodigital dysplasia. Picture of the month.


Diphenylhydantoin--induced hepatic necrosis.


Quantitative scintigraphic method of estimating the circulation of cerebrospinal fluid.


Unit activity in accessory optic system in alert monkeys.


Cerebellopontine cisternography with a positive contrast medium.


Dose distribution analysis of moving-strip technique for abdominal irradiation using 10 MV x rays.


Letter: Norrie's disease.

Letter: Norrie's disease.


BB-K8: A new aminoglycoside for intravitreal injection in bacterial endophthalmitis.


Comparative responsiveness of euthyroid and hypothyroid rat pituitary tissue to thyrotropin releasing hormone in vitro.


Arterial infusion of 5-fluorouracil as a treatment for carcinoma of the prostate.


Enhancement and deactivation of some microsomal glycosyl transferases.


Purification and some serological properties of staphylococcal nuclease.


Passive electrical properties of toad urinary bladder epithelium. Intercellular electrical coupling and transepithelial cellular and shunt conductances. The electrical resistances of the transcellular and paracellular pathways across the toad urinary bladder epithelium (a typical "tight" sodium-transporting epithelium) were determined by two independent sets of electrophysiological measurements: (a) the measurement of the total transepithelial resistance, the ratio of resistance of the apical to the basal cell membrane, and cable analysis of the voltage spread into the epithelium; (b) the measurement of the total transepithelial resistance and the ratio of resistances of both cell membranes before and after replacing all mucosal sodium with potassium (thus, increasing selectively the resistance of the apical membrane). The results obtained with both methods indicate the presence of a finite transepithelial shunt pathway, whose resistance is about 1.8 times the resistance of the transcellular pathway. Appropriate calculations show that the resistance of the shunt pathway is almost exclusively determined by the zonula occludens section of the limiting junctions. The mean resistance of the apical cell membrane is 1.7 times that of the basal cell membrane. The use of nonconducting materials on the mucosal side allowed us to demonstrate that apparently all epithelial cells are electrically coupled, with a mean space constant of 460 microm, and a voltage spread consistent with a thin sheet model.


Gonogrow, an improved, selective medium for the isolation of Neisseria gonorrhoeae.


Evaluation of skin cleansing procedures using the wipe-rinse technique.


The use of sodium sulfite as a neutralizer for evaluating povidone-iodine preparations.


Fracture of the talus. A study of its genesis and morphology based upon cases with associated ankle fracture.


Rupture of the posterior talotibial ligament with the avulsion of a bone fragment from the talus.


Cardiohemodynamic effects of nitroglycerin and several vasodilators.


Angina pectoris induced by intravenous administration of 50 per cent glucose.


Thymineless death in Bacillus subtilis: correlation between cell lysis and deoxyribonucleic acid breakdown. Bacillus subtilis carrying an inducible defective phage is several times more sensitive to thymineless death than a mutagenized derivative that behaves as a nonlysogen. When the integrity of the deoxyribonucleic acid (DNA) of both strains was examined during thymine starvation by transformation experiments, sedimentation studies, and measurements of acid-soluble DNA degradation products, it was shown that extensive DNA breakdown occurred only in the lysogenic strain. During thymine starvation of this strain, there is a progressive proclivity to lysis, followed by leakage of DNA and DNA degradation products. Such leakage was not observed in the nonlysogen. A correlation between proclivity to lysis and extensive DNA degradation is indicated.


Sensitivity of an early step in the sporulation of Bacillus subtilis to selective inhibition by ethidium bromide. When a final concentration of 0.4 mug of ethidium bromide (EB) per ml, which is subinhibitory to vegetative growth, is added to sporulating cells of Bacillus subtilis Marburg during either stage 0 or the early part of stage 1, morphogenesis is blocked. If the given concentration of EB is added after the early part of stage 1, sporogenesis is unaffected. The synthesis of the serine protease and antibiotic, which are believed to be associated with sporulation events during the early part of stage 0, are not inhibited by EB. Enhanced binding of [(14)C]benzylpenicillin to sporulating cells during septation (stage 2) is a measure of the presence of terminal enzymes for germ cell wall peptidoglycan synthesis. EB does not interfere with the binding of penicillin to sporulating cells, but penicillin remains more permanently bound to EB-treated postlogarithmic cells than to untreated sporulating cells. The absence of an interval of increased penicillin binding activity during stage 2 by sporulating cells treated with EB indicates that EB blocks sporulation prior to the completion of the germ cell wall.


Adenine nucleotide changes associated with the initiation of sporulation in Bacillus subtilis. At the end of the exponential growth phase of Bacillus subtilis, there is a decrease in the energy level of the cell, whether expressed as adenosine triphosphate concentration or adenylate energy charge. Phosphate limitation of exponentially growing cells produces a similar decrease in the energy level of the cell, and sporulation is derepressed in the presence of 10 mM glucose. A reduction in the tryptophan concentration of the medium during phosphate limitation of the tryptophan auxotroph B. subtilis 168 prevented the decrease in energy charge. Cells do not sporulate under these conditions. Energy charge values of 0.30 to 0.35 found during sporulation do not lead to cell death.


Nitrogenase activity and photosynthesis in Plectonema boryanum. Nitrogen-starved Plectonema boryanum 594 cultures flushed with N(2)/CO(2) or A/CO(2) (99.7%/0.3%, vol/vol) exhibited nitrogenase activity when assayed either by acetylene reduction or hydrogen evolution. Oxygen evolution activities and phycocyanin pigments decreased sharply before and during the development of nitrogenase activity, but recovered in the N(2)/CO(2) cultures after a period of active nitrogen fixation. Under high illumination, the onset of nitrogenase activity was delayed; however, the presence of 3-(3, 4-dichlorophenyl)-1, 1-dimethylurea (DCMU) eliminated this lag. Oxygen was a strong and irreversible inhibitor of nitrogenase activity at low (>0.5%) concentrations. In the dark, low oxygen tensions (0.5%) stimulated nitrogenase activity (up to 60% of that in the light), suggesting a limited but significant respiratory protection of nitrogenase at low oxygen tensions. DCMU was not a strong inhibitor of nitrogenase activity. A decrease in nitrogenase activity after a period of active nitrogen fixation was observed in the N(2)/CO(2-), but not in the A/CO(2-), flushed cultures. We suggest that this decrease in nitrogenase activity is due to exhaustion of stored substrate reserves as well as inhibition by the renewed oxygen evolution of the cultures. Repeated peaks of alternating nitrogenase activity and oxygen evolution were observed in some experiments. Our results indicate a temporal separation of these basically incompatible reactions in P. boryanum.


Salivary Pseudomonas aeruginosa.

Salivary Pseudomonas aeruginosa.


Mechanism of inhibition of bacterial growth by adenine.


The stability of taka-amylase A immobilized on various sizes of matrix.


Septum formation in Escherichia coli: characterization of septal structure and the effects of antibiotics on cell division. Septa can be demonstrated in sections of Escherichia coli strains B and B/r after fixation with acrolein and glutaraldehyde. The septum consists of an ingrowth of the cytoplasmic membrane and the mucopeptide layer; the outer membrane is excluded from the septum until the cells begin to separate. Mesosomes have also been observed. The septum is highly labile and, except in the chain-forming strains, E. coli D22 env A and CRT 97, not easily preserved by standard procedures. The labile nature of the septum may be due to the presence of autolysin(s) located at the presumptive division site. Blocking division by addition of ampicillin (2 to 5 mug/ml) to cells of E. coli B/r produces a bulge at the middle of the cells; bulge formation is stopped by addition of chloramphenicol. Cephalosporins also induce bulge formation but may stop cell elongation as well as division. Bulge formation, due to the presumed action of an autolysin(s), may be an initial step in the septation sequence when the mucopeptide is modified to allow construction of the septum. In a nonseptate filament-forming strain, PAT 84, which ceases to divide at 42 C, bulge formation only occurs in the presence of ampicillin at the time of a shift-down at 30 C or at 42 C in the presence of NaCl (0.25 to 0.34 M). Experiments with chloramphenicol suggest that the filaments are fully compartmentalized but fail to divide owing to the inactivation, rather than loss of synthesis, of an autolysin at 42 C.


Separation of transfer RNA's from Bacillus subtilis, Bacillus stearothermophilus and chicken liver by polyacrylamide gel electrophoresis.


Partial purification and some properties of cyclamate sulfamatase.


Evidence for the role of disulfide bonds in the masking of chromophore groups in bovine kappa-casein.


Interspecific variability of red cell phosphoglycerate kinase in primates.


Clinical significance of native DNA antibodies in systemic lupus erythematosus and other connective tissue diseases.


Hperglycaemic hyperosmolar non-ketotic metabolic decompensation in diabetes.


The characterization of a Bacillus capable of blue-green bactericidal activity.


Induction of the L-phase of Listeria monocytogenes by rabbit alveolar macrophages in vitro.


Recent advances in parenteral nutrition.


Aliphatic alcohols and bacterial motile behavior.


Glycolipids of urinary tract transitional epithelium.


Studies on the degradation of sym-homospermidine by Pseudomonas aeruginosa.


Proceedings: Secretion of airway in anaphylactic shock and the effect of certain drugs.


Secondary respiratory infection in hospital patients: effect of antimicrobial agents and environment. A prospective study of 358 medical and 234 postoperative patients with clinical evidence of secondary chest infection showed that previous administration of antimicrobial agents greatly reduced the chance of obtaining a clear-cut laboratory report. In patients with radiographical evidence of pneumonia this led to a fourfold decrease in the overall rate of isolation of potential pathogens. Furthermore, 81 diverse "coliforms" were isolated from 258 medical and surgical patients who had received previous antimicrobial therapy while only four coliforms (all Escherichia coli) were isolated from 334 untreated patients. Thus the general hospital environment on its own seemed to have a negligible influence in promoting the growth of coliform flora in sputum. Any unique effect of underlying disease in this regard was masked by that of previous therapy. Finally, the results raised the possibility that previous antimicrobial therapy might have increased the risk of secondary pneumonia in hospital patients.


Use of elemental diets to correct catabolic states prior to surgery. An elemental diet was used to prepare 11 severely debilitated malnourished patients for operation. Indications included: 1) as a substitute for parenteral hyperalimentation when catheter sepsis occurred with the latter; 2) high small fistulae; 3) short bowel syndrome; 4) radiation enteritis; and 5) partial obstruction of the gastrointestinal tract. All patients were converted to a positive nitrogen balance as evidenced by a substantial gain in weight and in serum albumin levels. All tolerated corrective operations without difficulty and their wounds healed per primum.


Serum antibody in patients with breast disease: Correlation with histopathology. Antibody to a breast cancer antigen was detected by immunodiffusion or complement fixation in at least one serum sample in 46% of 84 patients with a diagnosis of carcinoma, 34% of 96 patients with fibrocystic disease and 25% of 44 patients with fibroadenoma. A single serum sample obtained from screenees of the Detection Center for Breast Diseases was tested by immunodiffusion only and antibody was found in 3 of 206 screenees (1.5%). Eleven of 13 patients with breast cancer metastatic to lymph nodes and no detectable serum antibody either had recurrence or were dead within 12 months of mastectomy. Fifteen of 18 patients with breast cancer metastatic to lymph nodes and with detectable serum antibody were alive and free of disease for up to 24 months. Histologic slides from patients with a diagnosis of fibrocystic disease or fibroadenoma were reviewed for the presence of ductal epithelial hyperplasia. Ductal epithelial hyperplasia was present in a similar per cent of patients with no detectable serum antibody as those with antibody detected in the serum. Severe sinus histiocytosis of the axillary lymph nodes was present in 45% of those cancer patients with serum antibody and only 11% of those cancer patients with no detectable serum antibody.


Unresponsiveness of exocrine rat pancreas to calcemic challenges (hypercalcemia, EDTA hypocalcemia or calcitonin administration) which influence stomach function.


Origin of cerebellar climbing fibers in the rhesus monkey.


Evaluation of genetic structure of Drosophila melanogaster population with respect to the characteristic radius incompletus. Report II. Verification of Wright and Fisher systems.


Contamination of cord blood with maternal blood during delivery.


The fine structure of cysts of Frenkelia (the M-organism).


The age of Ixodes ricinus ticks as a factor of their susceptibility to pp-DDT, imidan and carbaryl.


Inactivation of allantoinase of Pseudomonas aeruginosa in vivo.


Sequential gene activation by ecdysone in polytene chromosomes of Drosophila melanogaster. II. The effects of inhibitors of protein synthesis.


Monolayer mass culture on disposable plastic spirals.


EM49, a new peptide antibiotic. 3. biological characterization in vitro and in vivo.


Suppression of tumor growth and regression of established tumor with oil-attached mycobacterial fractions.


Distribution and excretion of cyclocytidine in monkeys, dogs, and rats.


DNA reassociation kinetics of closely related species.


Intercellular adhesion: modification by dielectric properties of the medium.


Changes in serum thyroxine-binding proteins in endemic goitre and endemic cretinism.


A comparison of effective thyroxine ratio, free thyroxine index and free thyroxine concentration in correcting for thyroxine-binding abnormalities in serum.


The clinical application of a new prosthetic arteriovenous shunt. Characteristics and advantages over the standard A-V shunt and the A-V fistula.


Prevention of induced autophagy by emetine in exocrine cells of mouse pancreas and seminal vesicle.


Isolation and partial characterization of the internal structural proteins from murine intracisternal A particles.


Fine structural alterations in mesothelial cells associated with cardiac anomaly.


Nuclear fibrous lamina in pathological human synovial membrane.


The behavior of delta-aminolevulinic acid levels in the blood of patients on regular dialysis treatment (RDT).


On the effects of tricarboxylic acid cycle intermediates on sodium transport by the toad bladder.


Ketogenesis and the Indian diabetic.

Ketogenesis and the Indian diabetic.


Letter: Hyperamylasemia and diabetic ketoacidosis.


Relationship of delayed-type hypersensitivity and acquired cellular resistance in experimental airborne tuberculosis.


Specific human antibodies to enterotoxins A, B, and C1 of Staphylococcus: their increased synthesis in staphylococcal infection.


Letter: Alcohol and the liver.

Letter: Alcohol and the liver.


Multiple gene sites for 5S and 18 plus 28S RNA on chromosomes of Glyptotendipes barbipes (Staeger). Ribosomal RNAs (28 + 18S and 5S) and 4S RNA extracted from the chironomid Glyptotendipes barbipes were iodinated in vitro with (125)I and hybridized to the salivary gland chromosomes of G. barbipes and Drosophila melanogaster. Iodinated 18 + 28 S RNA labeled three puffed sites with associated nucleoli on chromosomes IR, IIL, and IIIL of G. barbipes and the nucleolar organizer of Drosophila. Labeled 5S RNA hybridized to three sites on chromosome IIIR, two sites on chromosome IIR and one site in a Balbiani ring on chromosome IV of Glyptotendipes. Most of the label produced by this RNA was localized seven bands away from the centromere on the right arm of chromosome III, and we consider this to be the main site complementary to 5S RNA in the chironomid. This same RNA preparation specifically labeled the 56 EF region of chromosome IIR of Drosophila which has been shown previously to be the only site labeled when hybridized with homologous 5S RNA. Hybridization of G. barbipes chromosomes with iodinated 4S RNA produced no clearly localized labeled sites over the exposure periods studied.


The structural basis of selective gene expression in eukaryotes.


Thrombin substrates and the proteolytic site of thrombin action on human-platelet plasma membranes.


Effect of unilateral visual deprivation on the activities of acetylcholinesterase, cholinesterase and carbonic anhydrase of the optic lobe of pigeon.


Editorial: Blind children.

Editorial: Blind children.


Urinary excretion of fibrinogen-related materials, complement, and immunoglobulins in proliferative glomerulonephritis and after renal transplantation. Using a radial immunodiffusion technique we measured the urinary concentration of material related to complement (C3), IgM, and IgG along with fibrin-fibrinogen degradation products and heterophile (sheep) haemagglutinins in 15 patients with proliferative glomerulonephritis and in 10 patients after renal transplantation. There was a significant correlation between all variables measured, and serial studies showed that with the exception of IgG-related materials potentially useful information could be obtained on the detection of rejection and the response to treatment in both conditions. The significance of these observations is discussed.


Prolactin response to thyrotrophin releasing hormone in thyrotoxicosis.


Effects of vasopressin on toad bladder membrane proteins: relationship to transport of sodium and water.


Editorial: Facial hyperkinesis.

Editorial: Facial hyperkinesis.


Artificial feeding of prisoners.

Artificial feeding of prisoners.


Inquest on hunger-striker.

Inquest on hunger-striker.


The agar gel double diffusion test for detection of the Australia antigen.


On the chemical aspects of penicillin activity.


The influence of dietary intake on endogenous acid production. Theoretical and experimental background.


Synthesis of von Willebrand factor by cultured human endothelial cells. Cultured human endothelial cells synthesize and secrete a protein(s) which has Factor VIII antigen but which lacks Factor VIII clot-promoting activity (J. Clin. Invest. 52, 2757-2764, 1973). Von Willebrand factor activity has been identified in medium from cultured human endothelial cells. This activity was demonstrated by the ability to correct the defect in platelet adhesiveness of blood obtained from patients with von Willebrand's disease. This activity also supported ristocetin-induced aggregation of washed normal human platelets. The von Willebrand factor activity from cultured endothelial cells has physicochemical and immunologic properties like those of the von Willebrand factor activity and the Factor VIII antigen present in human plasma and the Factor VIII antigen synthesized by human endothelial cells in vitro. Rabbit antibody to chromatographic fractions containing endothelial cell von Willebrand factor inhibits the platelet retention of normal blood in glass bead columns.


Effect of the lesion of the mammillary bodies on the performance in the open field.


Studies on the activated sludge bacteria participating in the biodegradation of methanol, formaldehyde and ethylene glycol.  I. Isolation and identification.


Studies on the activated sludge bacteria participating in the biodegradation of methanol, formaldehyde and ethylene glycol. II. Utilization of various carbon and nitrogen compounds.


35Cl nuclear magnetic resonance study of zinc and phosphate binding of E. coli alkaline phosphatase.


Protomer stability and sclerotization in vitro.


An immunochemical study of the calcium ion-binding protein (troponin-C) and the inhibitory protein (troponin-I) of the troponin complex and their interaction.


Distribution of microtubules in the golgi apparatus of Euglena gracilis.


Plasticity of cortical cell firing patterns after load changes.


The membrane surfaces of the toad bladder: scanning and transmission electron-microscopy.


D2O-alanine exchange reactions catalyzed by alanine racemase and glutamic pyruvic transminase.


Neutral proteinase of rabbit skin: an enzyme capable of degrading skin protein and inducing an inflammatory response.


Analytical-band centrifugation of the active form of pig kidney diamine oxidase.


Biogenesis of multiple cellulase components of Pseudomonas fluorescens var. cellulosa. I. Effects of culture conditions on the multiplicity of cellulase.


Staining of myofibrils with fluorescent antibody against the 10S component of the original alpha-actinin preparation.


Proceeding: The site of conduction block in peripheral nerves compressed by a pneumatic tourniquet.


Proceedings: Effect of prostaglandins on water transport across the isolated toad bladder.


Proceedings: The effect of ouabain, low temperature and exposure to Li solutions on cation fluxes in amphibian oocytes.


Proceedings: The effect of thyrotrophin releasing factor on the secretion of thyroid stimulating hormone and prolactin from the chicken anterior pituitary gland.


The limitations and dangers of commerciogenic nutritious foods.


HL-A antigens and some immunological parameters in psoriasis.


The relevance of a serological classification of chronic hepatitis.


Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis.


Gastrointestinal transit time in ovarian carcinoma irradiated with 60Co.


Estimation of the size of a T-cell-induced lytic lesion.


Brain activity during emotional states.

Brain activity during emotional states.


Effect of bicarbonate on oxygen transport in juvenile diabetic ketoacidosis.


Prevention of adhesion in injury of the extensor mechanism of the fingers.


Structure activity relationship in sixteen membered macrolide antibiotics.


Potential antileprotic agents. 3. Inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines.


Studies of prolactin and TSH secretion by continuous infusion of small amounts of thyrotropin-releasing hormone (TRH).


The use of 4-6 MeV electrons for the conservative treatment of retinoblastoma.


The ultrastructure of the human placental bed.


Diphtheria toxin and mutant proteins.

Diphtheria toxin and mutant proteins.


The surgical treatment of carcinoma of the oesophagus.


Enhancement of cord factor-toxicity by sulfolipid.


Stereochemistry and toxicity of cord factor.


Evaluation of some morphological characteristics of spores of two species of Microsporida by scanning electron microscope and freeze-etching techniques.


Functional and electron microscopic changes in the trabecular meshwork remaining after trabeculectomy in cynomolgus monkeys.


Failure to induce autoimmune disease with neonatal bursectomy in chickens.


Studies on the mouse mammary tumour agent (MTA). IV. Lactate and malate dehydrogenase isozymes in normal mammary gland of R3f, C57BL and in virus-induced and spontaneous mammary adenocarcinoma in C57BL and R3 mouse strains.


Distribution of alkaline phosphatase in the digestive system of a few teleost fishes.


Mechanisms regulating ovarian cycle in the toad Bufo bufo bufo (L): role of presence of second growth phase oocytes in controlling recruitment from pool of first growth phase oocytes.


Some biological and morphological characteristics of the agent 3053 LB isolated from the plasma of a leukemic cow.


Roentgenologic determination of foetal maturity.


Microcalorimetry applied to certain species of bacteria growing in sterilized separated milk.


Secretion of collagen by corneal epithelium. II. Effect of the underlying substratum on secretion and polymerization of epithelial products.


Incorporation of 3H-thymidine in rhesus monkey (Macaca mulatta) embryos.


Antibodies against Sertoli cells in human infertility.


Endogenous endotoxemia during hemorrhagic shock in the subhuman primate.


Postoperative nutrition and colonic wound healing, serum protein metabolism, and body weight.


Insulin response in patients undergoing prolonged intravenous hyperalimentation.


Cortisol responses to normotensive and hypotensive oligemia in unanesthetized primates.


Treatment of acute renal failure with intravenous administration of essential amino acids and glucose.


Portacaval shunt in established experimental mammary carcinoma.


Pulmonary function studies with Xenon 133 after orthotopic cardiopulmonary autotransplantation in primates.


Acid and gastrin response to acute hypercalcemia in conscious monkeys.


An inhibitor, obtained from primates, of gastrin-stimulated gastric acid in rats.


Gastrin response to feeding.

Gastrin response to feeding.


External compression of the cardia related to gastroesophageal reflux.


Normothermic vs hypothermic perfusion in treatment of acute experimental spinal cord injury.


Cerebral blood flow and its responsiveness to arterial PCO2: alterations before and after experimental head injury.


Middle cerebral arterial spasm from subarachnoid blood: spasmolysis with topical use of nitroglycerin.


Effect of cryosurgery on the tympanic membrane.


Long-term recording of primate cochlear potentials through an inner ear electrode implant.


Correlation between buccal smear abnormalities and serum protein levels in infants suffering from protein calorie malnutrition and vitamin A deficiency.


Non-reciprocal intragenic mitotic recombination in Drosophila melanogaster.


The genetics of some second chromosome melanotic tumour mutants of Drosophila melanogaster.


Glycoside conjugative activity in different insect and vertebrate species.


Detection of metabolic carcinogen intermediates in urine of carcinogen-fed rats by means of bacterial mutagenesis.


Nitroglycerin-induced suppression of excitation of afferent cardiac sympathetic nerves during myocardial ischemia.


Regulation of neutral protease productivity in Bacillus subtilis: transformation of high protease productivity. A transformable strain of Bacillus subtilis 6160, a derivative of B. subtilis 168, produces three kinds of casein hydrolytic enzymes (alkaline protease, neutral protease, and esterase) in a culture medium. B. natto IAM 1212 produces 15 to 20 times as much total proteolytic activity as does B. subtilis. Extracellular proteases produced by the two strains were separated into each enzyme fraction by diethylaminoethyl-Sephadex A-50 column chromatography. The difference in the total protease activities of extracellular proteases between the two strains was due to the amount of neutral protease. The ratios of neutral protease activity to alkaline protease activity (N/A) were 1.1 in B. subtilis 6160 and 13.0 in B. natto IAM 1212. Enzymological and immunological properties of alkaline protease and neutral protease obtained from the two strains were quite similar or identical, respectively. Specific activities measured by an immunological analysis of the two neutral proteases against casein were also equal. A genetic character of high protease productivity in B. natto IAM 1212 was transferred to B. subtilis 6160 by the deoxyribonucleic acid-mediated transformation. Among 73 transformants that acquired high protease productivity, 69 produced a higher amount of neutral protease and the ratios of N/A were changed to 15 to 60. Three other strains were transformed in the productivity of neutral protease and alpha-amylase simultaneously, and one showed considerable change in the production of alkaline protease and neutral protease. The specific activities (casein hydrolytic activities/enzyme molecules) of neutral proteases from the representative four transformants were equal to those of the two parental strains. These results suggested the presence of a specific gene(s) that participated in the productivity of neutral protease in B. subtilis.


Protein-calorie malnutrition. A host determinant for Pneumocystis carinii infection.


Further investigations on pulsatile movements in the cerebrospinal fluid pathways.


The healing of experimentally induced pulpitis.


M-protein.

M-protein.


Problems of immunology in myasthenia, polymyositis and Guillain-Barré syndrome.


Immunoglobulins of the Indian buffalo.

Immunoglobulins of the Indian buffalo.


Absorption spectra of algal and chloroplast suspensions: a simple method using conventional spectrophotometers.


Letter: Biological effects of azomycin (2-nitro-imidazole): inhibition of ribonucleotide reductase.


Antibody deficiency syndromes in children. Analysis of serum immunoglobulins in 1170 hospitalized children.


Chromatographic separation and serologic analysis of antibodies in the sera of mothers with ABO incompatibility.


Influence of Corynebacterium diphtheriae and pseudodiphtheriae on embryonic quinea pig cell cultures. II. Ultrastructural studies on infected culture cells.


Enzymatic repair of deoxyribonucleic acid; the biochemical and biological repair properties of a deoxyribonucleic acid polymerase from micrococcus luteus.


The enzymic and non-enzymic degradation of colneleic acid, an unsaturated fatty acid ether intermediate in the lipoxygenase pathway of linoleic acid oxidation in potato (Solanum tuberosum) tubers. Colneleic acid is an unsaturated ether fatty acid derived from linoleic acid via a lipoxygenase-mediated enzyme pathway. It is degraded (a) by an enzyme in potato tubers which is heat-labile and non-dialysable and (b) by a model system containing catalytic amounts of Fe(2+) ions. Both enzyme- and Fe(2+)-catalysed systems have similar properties with respect to pH optima (pH5.0-5.5), oxygen requirement (0.6-0.7 mol of O(2) consumed/mol of ether degraded), inhibitors and reaction products. An unstable product breaks down to C(8) and C(9) carbonyl fragments. Both systems are inhibited by low concentrations of antioxidants (e.g. 5mum-butylated hydroxytoluene) and some chelating agents (e.g. 5mum-diethyldithio-carbamate). The model system is strongly inhibited by metal ions, particularly Cu(2+) and Fe(3+), at 20mum. Hydrogen peroxide and haemoproteins do not substitute for the enzyme or Fe(2+) ions but the non-haem iron protein, ferredoxin, does catalyse the degradation.


New problems in sonar diagnosis in obstetrics and gynecology.


Pathophysiology of Salmonella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies.


A physiological model to study gallbladder function in primates.


Letter: Long-term parenteral nutrition.

Letter: Long-term parenteral nutrition.


Letter: Pheochromocytoma and hyperparathyroidism.


Cost of medical care in a practice of internal medicine. A study in a group of seven internists.


Amoxicillin: in vitro susceptibility of "blood culture strains" of gram-negative bacilli and comparisons with penicillin G ampicillin, and carbenicillin.


Determination of blood acetylcholinesterase inhibition caused by reversible inhibitors in vivo.


Amoxicillin in the treatment of uncomplicated gonococcal urethritis in males.


Minicells of Bacillus subtilis. A unique system for transport studies.


Letter: Acute brucellosis presenting as epididymo-orchitis.


Contamination of blood cultures from a commercial beta-lactamase preparations.


Diabetic ketoacidosis presenting as neurosurgical emergencies. Three cases of ketoacidosis in previously unsuspected diabetics are described. Each was admitted to hospital as a neurosurgical emergency. The recognition of this rare presentation is stressed since prompt treatment of the metabolic disturbance rapidly resolves the neurological abnormality.


The bladder lymphatics. A study of drug transport.


Serum beta 2-glycoprotein 1 phenotype frequencies in an English population.


Mannose phosphate isomerase: additional variants in primates.


A method for cloning anchorage-dependent cells in agarose.


Plant carbonic anhydrase. Properties and carbon dioxide hydration kinetics.


Structure of immunoglobulin A. Cysteine-containing peptides of the alpha chain of an immunoglobulin A-1 myeloma protein.


Potatoes and spina bifida.

Potatoes and spina bifida.


The TSH, FSH and prolactin responses to continuous infusions of TRH and the effects of oestrogen administration in normal males.


Thyroid function in euthyroid subjects with autonomous thyroid nodules.


Proceedings: 313. Unit activity of the prefrontal cortex and light-lever press reaction.


Control of sn-glycerol 3-phosphate oxidation in brown adipose tissue mitochondria by calcium and acyl-CoA.


Disc-gel electrophoresis of plus and minus strains and of gymnothecial cultures of Arthroderma tuberculatum.


Effect of dimethyl sulfoxide on natural resistance to bacterial infections in mice.


Ultrastructure of Rhodospirillum rubrum after freeze-etching.


Mutagenic activity of the insecticide oxydemetonmethyl in a resistant strain of Drosophila melanogaster.


Titration of precipitating antibody in equine infectious anemia.


Bacillus cereus outgrowth "early proteins" and their possible role in control of transcription.


Genetic analysis of rec mutants of Bacillus subtilis. Evidence for at least six linkage groups.


Multi-locus polymorphism and selection in a population of Drosophila melanogaster. I. Linkage disequilibrium on chromosome 3.


Ankle sprains in young athletes. Relation of severity and disability.


Light and electron microscopic studies of rat kidney after administration of inhibitors of the citric acid cycle in vivo. A morphological and histochemical study of the pars recta during malonate poisoning.


Effects of 5-bromodeoxyuridine on rat embryo cell cultures.


Quantitative cytochemical estimation of the effect of pentagastrin (0.005-5 pg-ml) and of plasma gastrin on the guinea-pig fundus in vitro.


Quantitative changes in mitochondria of guinea pig myocardium following anaesthesia with halothane.


Urinary acidification and carbonic anhydrase distribution in bladders of Dominican and Colombian toads.


Clinical assessment of glybenclamide (daonil) in diabetes mellitus.


Neurofibromatosis with meningioma orbit (a case report).


TRH stimulated TSH response in euthyroid healthy subjects and patients with thyroid dysfunction.


Biological characterization of a high energy neutron beam for radiation therapy.


Localization error in the radiotherapy of Hodgkin's disease and malignant lymphoma with extended mantle fields.


Urine homovanillic acid and tissue dopa oxidase in patients with melanoma.


The RBE of neutrons in vivo.

The RBE of neutrons in vivo.


A comparative study on drug hydroxylation and glucuronidation in liver microsomes of phenobarbital and 3-methylcholanthrene treated rats.


A report on three years' fast neutron therapy from the Medical Research Council's cyclotron at Hammersmith Hospital, London.


An experimental model for chronic communicating hydrocephalus.


Sequential changes of vascular ultrastructure in experimental cerebral vasospasm. Myonecrosis of subarachnoid arteries.


Extradural ossification following an extradural hematoma. Case report.


Effects of operantly conditioning epileptic unit activity on seizure frequencies and electrophysiology of neocortical experimental foci.


Recent research on malaria in mammals excluding man.


New knowledge of toxoplasma and toxoplasmosis.


Errors in performance and interpretation of echocardiograms.


The influence of ovarian sonication on fetal development in the rat.


The pancreatic beta-cell recognition of insulin secretagogues. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone.


Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoadsorbents.


Effect of vitamin B-12 deprivation on the rates of synthesis and degradation of rat liver fatty acid synthetase.


Chemical and physical properties of a carotenoprotein from Rhodospirillum rubrum.


Studies on Fd-fragments of human immunoglobulins. II. The preparation and characterization of peptic (Fab')2-fragments and an Fd'-fragment of IgA-myeloma proteins.


The influence of magnesium on the chlorophyll fluorescence yield of isolated chloroplasts.


Studies of serum from patients with breast cancer.


Comparative scrapie activity of brain material and cerebrospinal fluid from scrapie-affected rats.


Studies on dextranase. II. New exo-dextranase from Brevibacterium fuscum var. Dextranlyticum.


The sulfhydryl groups of porcine pancreatic alpha-amylase: unmasking, reactivity and function.


Activation energy of glucuronide biosynthesis.


DNA-dependent poly (G) synthesizing activities in DNA-dependent RNA polymerase fractions from cauliflower inflorescence.


Single-dose oral therapy for uncomplicated gonorrhea: comparison of amoxicillin and ampicillin given with and without probenecid.


Therapy of uncomplicated gonococcal urethritis in the male with a single dose of amoxicillin.


Treatment of uncomplicated gonorrhea with amoxicillin.


Experimental Pseudomonas granuloma in the skin of guinea pigs.


Treatment of uncomplicated gonorrhea in women with a single dose of amoxicillin.


The trypanosomes of anura.

The trypanosomes of anura.


Comparative study of the function of polytene chromosomes in laboratory stocks of Drosophila melanogaster and the l(3)tl mutant (lethal tumorous larvae). I. Analysis of puffing patterns in autosomes of the laboratory stock Batumi-L.


Diagnostic ultrasound in radiation treatment planning.


Changed pattern of transcription and replication in polytene chromosomes of Drosophila melanogaster resulting from eu-heterochromatin rearrangement.


Prednisolone-induced mucormycosis in rhesus monkeys.


Metabolism of carbaryl by selected human tissues using an organ-maintenance technique.


Lymphocyte stimulation in Candida albicans infections.


Mycologic, serologic and histologic findings in bovine abortion associated with Allescheria boydii.


Growth of measles virus in nervous tissues. II. Neurotropic properties of a SSPE virus in hamsters.


Effect of estrogen on serum total and free thyroxine and triiodothyronine in a thyroxine-binding globulin deficient family.


Normal values of the serum protein fractions in cynomolgus monkeys used as experimental animals.


Recent developments in magnesium research in pediatrics.


Glutathione reductase in the sea urchin egg. II. Cleavage-associating fluctuation of the activity and its possible regulatory mechanism.


Management of urinary tract infection in acute paraplegic patients with special reference to the paper strip screening test for infection.


Evidence of homology between the beta-chain of human haptoglobin and the chymotrypsin family of serine proteases.


The incidence of ABO and Rh blood groups in the Bellary area--a random survey.


Haemorrhagic complications after penicillin therapy.


The patterns of infection in cystic fibrosis.


Faulty proteins: altered gene products in senescent cells and organisms.


Circulatory effects of intravenously administered rolitetracycline and other tetracyclines in animal experiments.


Different immunofluorescent titres of Candida albicans blastospores and pseudohyphae.


Reflex (sensory precipitation) epilepsy (review and case report).


Agar ingestion and serum bilirubin values in newborn infants.


Genetic improvement of plant protein.

Genetic improvement of plant protein.


Comparative in vitro activity of kanendomycin, kanamycin, gentamicin and streptomycin against 100 consecutive cultures of tubercle bacilli recovered from patients.


National health insurance proposals: which one will it be?


Accumulation of dietary polychlorinated biphenyls (Aroclor 1254) by rainbow trout (Salmo gairdneri).


Immunológical studies in lymphoma patients IX. Detection of antimycotic antibodies.


A method to demonstrate the specificity and sensitivity of fluorescent antibody by immunoelectrophoresis and immunodiffusion using ultraviolet light photography.


Electroimmunodiffusion on cellulose acetate: a rapid method for analysis of bovine lactoferrin in chromatography effluents.


Uptake of glibornuride by microdissected pancreatic islets.


Isolation and purification of an organ-specific autoantigen from rabbit seminal plasma.


Letter: Effects of formaldehyde and glutaraldehyde fixation on the monoamine oxidase activity in isolated rat liver mitochondria.


Transcription of mammalian satellite DNAs by homologous DNA-dependent RNA polymerases.


Coatings as barriers to prevent polychlorinated biphenyl contamination of silage.


Effect of photooxidative conditions on levels of superoxide dismutase in Anacystis nidulans.


Analysis of herbicides.

Analysis of herbicides.


Synthesis of 3'-amido-3'-deoxyadenosine 3',5'-cyclophosphate.


Exchange within heterozygous inversions in Drosophila melanogaster. The exchange behavior of non-attached, whole arm, X chromosome inversions was reexamined using nondisjunction in XXY females as an indirect measure of the frequency of nonexchange tetrads. Crossing over is quite normal in these inversion heterozygotes and is independent of the arrangement of the basal heterochromatin.


Specificity of purified hemagglutinin (lectin) from Lotus tetragonolobus.


Complementation analysis of late lethal mutants of Drosophila melanogaster. Late larval and pupal lethal mutants of Drosophila define those gene functions which are essential for the development of pupae (metamorphosis) but not for embryonic or larval development. In a previous report the isolation of a large number of such mutants was outlined, and a description of the imaginal disc defects in those mutants was described. This report concerns genetic analysis of those mutants. 3746 different pairwise combinations of mutants have been tested for complementation. Only 10 pairs fail to complement. In all of the cases tested, the lethal mutation in each member of a non-complementing pair has a similar map location. In addition to the non-complementing pairs one group of seven partially-complementing mutants has been identified. Comparisons of the imaginal disc defects within the non-complementing pairs and the lethal hybrids formed by the respective pairs were made to test for uniformity of phenotype. No significant qualitative differences were detected between any non-complementing pairs or their respective hybrids.


Hypertension detection by dentists.

Hypertension detection by dentists.


Marginal leakage of various restorative materials.


Effects of 60Co gamma irradiation on aflatoxin B1 and B2 production by Aspergillus flavus.


Seizures in patients over the age of 40: a general hospital study.


Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain.


Electrocardiogram as a guide to potassium replacement in diabetic ketoacidosis.


Cecal diverticulum strangulated in femoral hernia.


Amniotic fluid tests for fetal maturity.


Development of enteric parasites in parenterally fed rats.


Stimulation of prolactin and growth hormone release by TRH infused into a hypophysial portal vessel.


Tay-Sachs' disease and Fabry's disease: clinical and chemical diagnosis of two metabolic eye diseases.


Relationship of ambient temperature to serum prolactin in heifers.


Intravenous hyperalimentation.

Intravenous hyperalimentation.


The diagnosis of myocardial infarction in the Wolff-Parkinson-White syndrome.


The social context of coronary artery surgery.


The effects of extraoral low-pull traction to the mandibular dentition of Macaca mulatta.


Neuromuscular and skeletal adaptations to altered function in the orofacial region.


Gastric clearance of serum albumin in normal man and in certain gastroduodenal disorders. Serum albumin gastric loss was estimated from the measurement of non-dialysable radioactivity of the gastric juice after intravenous injection of radioiodinated serum albumin (RISA). Immunochemical quantitation of serum albumin was performed in some of the samples. In the control group, the mean gastric clearance of albumin was 1.71 ml per hour with a range of 0.41 to 4.41 ml per hour. This represented a gastric loss of 1.9 gram of albumin per day and 11% of the daily degradation of albumin. There was no significant change in the gastric albumin loss after stimulating the gastric secretion. No significant difference in the gastric albumin leakage was found between normal subjects and patients with gastric or duodenal ulcer. IN PERNICIOUS ANAEMIA ALBUMIN LOSS INTO THE STOMACH WAS GREATER (MEAN: 3.72 ml per hour; SD 1.52 ml) than in the normal group and accounted for the greater albumin fractional catabolic rate. This fact had never been proved before. In both patients with giant rugae of the gastric mucosa the gastric clearance of serum albumin was also increased. It is concluded first that albumin is not secreted by the chief and parietal cells of the mucosa and probably passes through the gastric wall between the cells of the mucosa, perhaps during the exfoliation of the surface epithelial cells, and secondly that the stomach is one of the sites of serum albumin breakdown, a fact that supports the view that the gastrointestinal tract plays a major role in the catabolism of serum albumin.


Dietary fat and coronary heart disease: A review. I. Diet in the prevention of coronary heart disease and some pathogenetic aspects.


Resistance of Neisseria gonorrhoeae to penicillin in 199 gonococcal infections in women and the response of those infections to penicillin treatment.


Physical changes in the bone tissue of the skull due to head injury.


Kinetic behavior of enzymes in artificial membranes. Inhibition and reversibility effects.


The role of insulin and growth hormone in fetal growth.


Letter: Comparison of pain cry in neonates with and without feeding tube.


Effect of caffeine on crossing-over in Drosophila melanogaster.


Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.


Antigenicity of normal and tumoral glycoproteins correlated with their action on serum glycoproteins.


The influence of radiation on blood vessels and circulation. Chapter VII. Functional response of heart and major vessels.


Special needs of long-term patients.

Special needs of long-term patients.


Actions of lithium ions and insulin on glucose utilization, glycogen synthesis and glycogen synthase in the isolated rat diaphragm.


Stepping movements evoked by repetitive dorsal root stimulation in a mesencephalic cat.


Cortico-mamillary tracts of the brain.

Cortico-mamillary tracts of the brain.


Dominant afferentation and quantitative reorganization of auditory and visual analyzers in the brainstem of carnivores and primates, including man.


Cleavage of actin by thrombin.

Cleavage of actin by thrombin. Under certain conditions actin can be split by thrombin. Actin prepared in the presence of excess Ca(++) was found to be resistant to thrombin. However, if actin was purified without added Ca(++), both G- and F- actin underwent thrombic digestion, although a considerable proportion of actin molecules remained intact. Similar results were obtained with actin (in 50% sucrose) devoid of nucleotide and divalent cations but retaining its native characteristic. The removal of tightly bound Ca(++) from actin by EDTA accelerated the thrombic splitting and made the complete fragmentation of G-actin possible. Thrombin first cleaves actin into two pieces and subsequently one of them, fragment K (molecular weight 37,000 on sodium dodecyl sulfate-polyacrylamide gel), splits further, resulting in fragments L (molecular weight 27,000) and M (molecular weight about 10,000).


Actin antibody: the specific visualization of actin filaments in non-muscle cells. Actin purified from mouse fibroblasts by sodium dodecyl sulfate gel electrophoresis was used as antigen to obtain an antibody in rabbits. The elicited antibody was shown to be specific for actin as judged by immunodiffusion and complement fixation against partially purified mouse fibroblast actin and highly purified chicken muscle actin. The antibody was used in indirect immunofluorescence to demonstrate by fluorescence light microscopy the distribution and pattern of actin-containing filaments in a variety of cell types. Actin filaments were shown to span the cell length or to concentrate in "focal points" in patterns characteristic for each individual cell.


Radiology of small intestinal bleeding.

Radiology of small intestinal bleeding.


Homology between bakers' yeast cytochrome b2 and liver microsomal cytochrome b5. The amino-acid sequence of the hemebinding region of bakers' yeast cytochrome b(2) [L-(+)-lactate dehydrogenase, EC 1.1.2.3] has been determined. It shows a strong similarity with the sequence of microsomal cytochrome b(5), and appears to be compatible with the same kind of peptide-chain folding, in agreement with data obtained previously by various physiochemical methods. The comparison shows that the fifth and sixth heme ligands must be histidine residues, thus substantiating previous conclusions drawn in particular from photooxidation experiments and nuclear magnetic resonance studies. The data reported in this paper suggest a common origin for the two proteins. Implications for their biochemical evolution are presented.


Functional differences in the multiple hemocyanins of the horseshoe crab, Limulus polyphemus L. Hemocyanin in the hemolymph of the horseshoe crab, Limulus polyphemus L., is a high-molecular-weight copper protein which binds oxygen cooperatively and shows a higher oxygen affinity at pH 7 than at pH 9. Treatment with EDTA (ethylenediaminetetra-acetate) disaggregates the hemocyanin molecules and abolishes both the reverse Bohr effect and cooperative oxygen binding. Chloride ions interact with the EDTA-treated material and, in the presence of saturating amounts of NaCl, a reverse Bohr effect is restored, but cooperativity is not. The EDTA-treated hemocyanin contains at least five electrophoretically distinct hemocyanins. These hemocyanins have similar molecular weights (about 66,000) but are functionally dissimilar. They have different oxygen affinities and different responses to chloride ions. The effect of chloride ions on unfractionated hemocyanin is due to pH-dependent chloride interactions with only two of the five hemocyanin components. The functional differences between the hemocyanin components may provide Limulus with a valuable respiratory flexibility in its interaction with the environment. The kinetics of oxygen combination and dissociation for the various hemocyanin preparations show that variations in the rate of oxygen dissociation are primarily responsible for the observed differences in oxygen affinity. The rate of oxygen dissociation varies 20-fold under conditions where the apparent rate of oxygen combination shows less than a 2-fold variation. Cooperative interactions in the untreated hemocyanin are most obvious in the "off" reaction, which increases in rate as successive oxygen molecules are released.


Myonecrosis in chronic experimental vasospasm.


The effects of testosterone on the sexual skin and genitalia of the male talapoin monkey.


Degradation of immunoglobulins by secretions of human reproductive tracts.


Proceedings: Electrical responses of the limbic regions to exogenous testosterone and stimulation of the genital regions.


The first two electron linear accelerators in South Africa.


Proplast in cavity obliteration and soft tissue augmentation.


Studies on physiology and biochemistry of mammalian epididymis: Histology, enzyme and electrolyte composition of epididymis--a comparative study.


Influence of biological criteria on the magnitude of damage induced by gamma-rays and gamma-irradiated medium.


Genetic effects induced in Drosophila melanogaster cultured on irradiated glucose medium.


Induction of mutations by thioridazine hydrochloride, an active ingredient of Mellaril.


Fermentative production of alpha-amylase by Aspergillus flavus.


Detection of preformed enterotoxins of staphylococci in dairy products employing serological method.


Etiology of tuberculosis cutis in Jakarta.


Need for improved plant proteins in world nutrition.


Influence of external factors on extracellular amino acid accumulation by Bacillus megaterium strain C II 19.


Australia antigen in chronic liver diseases.


Gonadotropins and their antibodies.

Gonadotropins and their antibodies.


Viruses and the etiology of diabetes.

Viruses and the etiology of diabetes.


Fetal electrocardiographic evaluation of Rh-immunized pregnancies. Preliminary results by a new averaging technique.


Preliminary results of Rh-prophylaxis during pregnancy.


Morphologic changes of uterine wall following intra-amniotic injection of hypertonic saline in the rhesus monkey.


Firing patterns of hypothalamic supraoptic neurons during water deprivation in monkeys. Water deprivation in monkeys caused an acceleration of action potential firing of supraoptic neurons, but not of neurons located 2 to 3 millimeters above the hypothalamic supraoptic nucleus. Whereas in the normally hydrated animal only 12 percent of the neuroendocrine cells discharged periodically, the proportion of these periodic bursters increased markedly with increasing plasma osmolarity. This finding suggests that such periodically firing supraoptic neurons are those engaged in active neurohypophyseal hormone secretion.


Intrathoracic meningocele associated with multiple neurofibromatosis: a rare cause of mediastinal tumour.


Prevention of Rh immunization in Germany.


Irreversible binding of ethynyl-estradiol metabolites to protein and nucleic acids as catalyzed by rat liver microsomes and mushroom tyrosinase. It is known that most carcinogenic chemicals can be bound irreversibly to proteins or nucleic acids.  A study is presented that explored the irreversible binding of 17alpha-ethinyl estradiol to proteins and nucleic acids by the catalytic action of rat liver microsomes and muschroom tyrosinase.  The microsomal binding reaction was inhibited by glutathione and cysteine and its derivatives though it was not affected by lysine and amines.  Binding reactivity in the tyrosinase system was inhibited by glutathione, cysteine and its derivates, lysine, and amines.  Polylysine did not bind the metabolite of ethinyl estradiol, which suggests the NH2 groups do not bind to the intermediate in the microsomal reaction.  However, polylysine did bind irreversibly with esthinyl estradiol metabolites in tyrosinase catalysis.  The nonenzymatic reaction of 17beta-hydroxy-4,10(1)-estradiene-2,3-dione with cysteine, lysine, and lysine derivates was found to support the thesis that estrogen o-quinones are the intermediates involved in the protein binding of estrogens  in tyrosinase catalysis.  An irreversible binding of ethinyl estradiol to DNA and RNA occurred with tyrosinase but not with rat liver microsomes.  It was concluded that the results of rat liver microsome catalysis make it unlikely that estrogens are chemical carcinogens.


Trace analysis of organic compounds.

Trace analysis of organic compounds.


The sulfonamide-aminosulfone rearrangement: a rearrangement induced anionically, cationically, and thermally.


The pigments of reddish hair and feathers.


The continuing problem of sepsis-following enzymatic debridement of burns.


Stroke: early portents of functional recovery in Black patients.


Mass transfer of Co2 across membranes: facilitation in the presence of bicarbonate ion and the enzyme carbonic anhydrase.


An unusual tumour of the neck and superior mediastinum.


Single radial diffusion using catalase antibody as screening method of hypocatalasemia.


The effects of protein calorie malnutrition on immune competence of the surgical patient.


Evaluation of mitochondrial function in the ischemic rat liver.


Epithelial cell phagocytosis of Listeria monocytogenes in the conjunctiva.


Primary reconstruction of depressed frontal skull fractures including those involving the sinus, orbit, and cribriform plate.


Epilepsy after monmissile depressed skull fracture.


The secretory immunologic system of fowl. IV. Serum and salivary immunoglobulins in normal, agammaglobulinemic and dysgammaglobulinemic chickens.


Animal model: Oxygen toxicity in nonhuman primates.


Liver cell differentiation in a chemically defined medium. Morphologic and enzymatic comparisons of in utero rat liver and liver rudiment grown in organ culture. The liver diverticulum of the 11-day rat embryo has been grown in a chemically defined medium. Cytodifferentiation and enzymatic activities in the organ culture have been compared with those in the embryonic liver developing in vivo. In the absence of hormone and tissue extracts the liver diverticulum grew and differentiated extensively in the synthetic medium. The appearance and development of cytoplasmic organelles (rough and smooth endoplasmic reticulum, Golgi complex and glycogen particles) and enzymatic activity (glycogen synthetase) in both the embryonic liver and the comparable organ-cultured liver diverticulum were parallel.


Pyelonephritis. 18. Effect of treatment on the pathology of enterococcal pyelonephritis in the rat. The effect of antimicrobial therapy on the histopathologic progression of experimental hematogenous pyelonephritis induced in rats by Streptococcus faecalis was studied. Treatment sufficient to render the renal parenchyma sterile strikingly decreased the incidence and severity of calyceal lesions, delayed the progression of papillary lesions but had little effect on the severity of cortical interstitial and tubular alterations. L-forms could not be demonstrated to participate in the pathogenesis of these lesions. Kanamycin had an independent nephrotoxic effect which complicated interpretation of the effect of therapy in animals receiving this agent.


Precipitation of serum and tissue proteins by phytohaemagglutinin (PHA) in breast cancer patients.


Reciprocal induction of cell division by cells of complementary mating types in Tetrahymena.


Sexual dimorphism in the secondary immune response of the Syrian hamster.


The rate of uptake of 3H-actinomycin during the cell cycle of Tetrahymena.


Rough membranes in Schizosaccharomyces pombe protoplasts.


Unit discharges in the mediodorsal nucleus of the squirrel monkey evoked by electrical stimulation of the olfactory bulb.


Electroencephalographic changes induced by cerebellar stimulation in freely moving primates.


Cortical cell discharge patterns in anticipation of a trained movement.


Changes in complement activity, serum proteins, and prothrombin time in guinea pigs fed rubratoxin alone or in combination with aflatoxin.


Pathogenesis of Trypanosoma equiperdum in deer mice (Peromyscus maniculatus).


Acute transmural myocardial infarction. Its occurrence in a young man without demonstrable coronary artery disease.


Familial hepatic cirrhosis in infants associated with alpha1-antitrypsin SZ phenotype.


Management of childhood asthma in Britain.


X-linked B lymphocyte deficiency. I. Panhypo-gamma-globulinemia and dys-gamma-globulinemia in siblings.


Comparative pharmacokinetics of amikacin and kanamycin.


Bioequivalency of generic and brand-named chlorpromazine.


Allozyme variation in the fruit flies Dacus tryoni and Dacus neohumeralis (Tephritidae).


Phenol oxidase activity and the lozenge locus of Drosophila melanogaster.


Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.


Two new antisickling agents and the use of amino acid salts.


Assay of serum folate: difference in serum folate values obtained by L. casei bioassay and competitive protein-binding assay.


A simple procedure for the isolation of IgG anti-nuclear antibodies from human serum.


A new colorimetric method for the determination of glutathione in erythrocytes.


Occupational allergy to animal dander and sera.


Synthesis of free ATP from membrane-bound ATP in chromatophores of Rhodospirillum rubrum.


Polarized light spectroscopy of photosynthetic membranes in magneto-oriented whole cells and chloroplasts. Fluorescence and dichroism.


Neuronal mechanism of the disynaptic inhibition evoked in primate spinal motoneurones from the corticospinal tract.


Effects of selective frontal lobe lesions on response to separation in adolescent rhesus monkeys.


Proteins in bull rete testis and cauda epididymidia plasma.


Induction of mitotic gene conversion in Saccharomyces cerevisiae by N-nitrosated pesticides.


A cytogenetic analysis of x-ray induced "visible" mutations at the yellow locus of Drosophila melanogaster.


The effect of caffeine on repair systems in oocytes of Drosophila melanogaster. I.


ATP-dependent deoxyribonuclease in Bacillus subtilis and a mutant deficient in this activity.