The effect of increased sodium chloride intake on the rate of formation and retention of alimentary conditioned reflexes in normally and prematurely weaned rats.


Iodine, solid diet, water and milk intake by lactating rats and their offsprings.


The effect of thyroidectomy at early ontogenetic stages upon oxidative processes in the rat brain.


Fat content and lipoproteinase activity in muscles of male rats with increased or reduced motor activity.


A comparison between 18 to 20-year-old students with average physique and trained individuals.


Development of the relationship between aerobic capacity and the circulatory and respiratory reaction to moderate activity in boys 11-13 years old.


Capacitance plethysmography of the nasal mucous membrane in man.


The breakdown of L-leucyl-p-nitroanilide by serum and tissue homogenates.


Osmotic resistance of leucocytes of some laboratory animals.


A comparison of the practical applicability of two methods used for the evaluation of the hypoxic reaction: factor analysis, multidimensional regression analysis.


The safety of physically disabled drivers.


Syngens of Paramecium aurelia in some regions of Moscow and Leningrad.


Synergism in recalcitrant acne vulgaris. A report of good results in 78 percent of patients who had failed to respond to other therapy methods.


The future role of local health authorities in the day care of the young child.


Role of the medical social worker in patient disposition.


Physical therapy and rehabilitation procedures related to industry.


Occupational therapy and pre-vocational testing.


Management's role in the utilization of the disabled.


Diagnosis and disability evaluations including special measurements.


Differential staining of acid glycosaminoglycans (mucopolysaccharides) by alcian blue in salt solutions.


A new ion association-fractionation technique for identifying individual mucopolysaccharides and other polyanions in tissue sections.


An assessment of work opportunities for the handicapped in the philippines.


Distribution of glycosaminoglycans, hydroxyproline and calcium in healing fractures.


Fibrinolytic and proteolytic activity in acute and chronic leukemia.


Histochemical study of acid mucopolysaccharides in the oviduct gland of Cynips folii.


Histochemistry of parablastomatous connective tissue.


Intracellular glycogen and other polysaccharides in human epidermal tumours.


The prevalence of handicapping conditions in childhood.


Clinico-hemodynamic correlations in ventricular septal defect in childhood.


Effect of L-histidine on hepatic histidine ammonia-lyase & histidine-pyruvate aminotransferase levels in rats.


Occurrence of L-amino: 2-glyoxylate aminotransferase in lower plants.


Deamination of amino acids by Azotobacter chroococcum.


Enzymatic preparation of (--) & (+) isomers of citramalic acid.


Synthesis of phospholipid in the blood of patients with essential hypertension.


Activities of some enzymes of pentose phosphate pathway of malignant cervix uteri during various stages of malignant growth.


Synthesis of an unstable functional ribonucleic acid in germinating wheat.


Studies on horse antibodies. I. Development of antibody in different fractions of serum during immunization of horse with diphtheria toxoid.


Studies on experimental protein malnutriton. I. Effect of threonine deficiency on glucose-6-phosphate metabolizing enzymes of rat liver.


Incorporation of glycine-1-14C into tissues & adult rats after protein depletion & repletion.


Availability of nicotinic acid in jowar (Sorghum vulgare).


Interdependence of dietary protein & vitamins in metabolism. II. Interdependence of vitamin A, ascorbic acid & protein in metabolism.


Role of vitamin A in sulphate metabolism: 3--Sulphate activation in hypervitaminotic A rats.


Purification of ox brain acetylcholinesterase.


Regulation of arginine biosynthesis in Vibrio cholerae.


Neurotoxic properties of N-substituted oxamic acids.


Metabolism of coumarin derivatives: a note on the urinary metabolites of calophyllolide, 4-phenylumbelliferone & 4-phenyl-7-methylumbelliferone.


Purification & physical properties of a goat intestinal esterase.


Chronic respiratory diseases--a mushrooming challenge.


Change of philosophy.

Change of philosophy.


Dermatologic cosmetic surgery.

Dermatologic cosmetic surgery.


Desiccated thyroid U.S.P. or sodium L-thyroxine?


Recent developments in hair preparations.


Evaluation of dermatologic creams containing female hormones.


A census of women physicians in the Washington, D.C. Metropolitan area.


My mother, the Doctor. Another solution to a much-discussed problem.


Studies on heart phosphofructokinase. Purification, crystallization, and properties of sheep heart phosphofructokinase.


Purification and properties of a tropomyosin-containing protein fraction that sensitizes reconstituted actomyosin to calcium-binding agents.


Low back pain.

Low back pain.


Familial mongolism by a G--G mosaic carrier.


Diagnosis and conservative treatment of ordinary low back pain.


Huntington's chorea, dysphagia and death.


The incidence of osteoporosis in normal women: its relation to age and the menopause.


An attempt for direct phage typing of pathogenic staphylococci.


Medical self-help and nutrition courses in Central America.


New drugs: the AMA and FDA roles.

New drugs: the AMA and FDA roles.


Hearing aids for hard of hearing patients.


Extraovular saline-induced abortion.

Extraovular saline-induced abortion.


Studies on the role of prophylactic desensitization in experimental myocarditis.


[On the problem of obtaining precipitating polio antigens].


Separation of adenosine diphosphate--adenosine triphosphate-exchange activity from the cerebral microsomal sodium-plus-potassium ion-stimulated adenosine triphosphatase. 1. A microsomal fraction from ox cerebral cortex catalysed [(14)C]ADP-ATP exchange at a speed similar to that at which it liberated P(i) from ATP in the presence of Na(+), K(+) and Mg(2+). 2. Repeated washing the fraction with MgATP solutions solubilized most of the exchange activity and left the adenosine triphosphatase insoluble and little changed in activity. The exchange activity was accompanied by negligible adenosine-triphosphatase activity and was enriched by precipitation at chosen pH and by DEAE-Sephadex. At no stage was its activity affected by Na(+), K(+) or ouabain. 3. The washed microsomal fraction was exposed to a variety of reagents; a sodium iodide-cysteine treatment increased both adenosine-triphosphatase and exchange activities, as also did a synthetic zeolite. Preparations were obtained with exchange activities less than 3% of their Na(+)-plus-K(+)-stimulated adenosine-triphosphatase activity. Some contribution to the residual exchange activity was made by an adenylate kinase. 4. Thus over 95% of the microsomal ADP-ATP-exchange activity does not take part in the Na(+)-plus-K(+)-stimulated adenosine-triphosphatase reaction. Participation of some of the residual 3% of the ADP-ATP-exchange activity has not been excluded, but there appears no firm evidence for its participation in the adenosine triphosphatase; the bearing of this conclusion on mechanisms proposed for the Na(+)-plus-K(+)-stimulated adenosine triphosphatase is indicated.


An outbreak of infection due to Staphylococcus aureus phage type 80/81 in a veterinary school.


The reversible activation of mitochondrial ATPase by high pH.


Fibrinolysin studies in hemophilia.

Fibrinolysin studies in hemophilia.


Lumbar facet fractures following disk surgery.


Evaluation of the 2-minute sit-up test as a measure of muscular endurance and strength.


Ultrastructure of the placenta in hypertensive states. The localization of enzmes hydrolysing adenosine triphosphate in placentae from normal and toxaemic pregnancies.


Children's dentistry--a challenge.

Children's dentistry--a challenge.


Existence of an apparent metabolic block in human granulation tissue.


Advance notice of dental surgery promotes good psychological responses.


A controlled trial of benzoyl peroxide and precipitated sulfur cream in acne vulgaris.


Low back pain in men receiving workmen's compensation.


Abnormal patterns of growth and development in mongolism. An anthropometric study.


Some aspects of the bacteriology of acne vulgaris.


Home care program for the chronically ill and the aged of the west regional district, Mayaguez, Puerto Rico.


Adenocarcinoma of the cervix uteri. Review of cases at the Dr. I. Gonzalez Martinez Oncologic Hospital.


Hospital practice in Appalachia; report on the Albert Schweitzer Memorial Hospital, Balsam Grove, North Carolina.


Diffuse glycogenosis.

Diffuse glycogenosis.


Air pollution and the lung.

Air pollution and the lung.


Air pollution and the heart.

Air pollution and the heart.


Four of us: sketches of the four women ophthalmologists of the Massachusetts Eye and Ear Infirmary.


An immunofluorescent study on anti-synovial tissue antibody in the body fluid from patients with rheumatoid arthritis.


Cellular antibody in mice bearing Ehrlich cancer. 3. Relationship of cellular antibody to serum antibody.


Fine structure of negatively stained adenovirus type 12.


The relationship between histochemical enzyme activities of brain tumors and clinical features of the patients.


Studies on the function of reticulo-endothelial system. II. Effects of the R.E.S. blocking with macro-molecular PVP on the lymphoid cell reproduction and the production of serum antibody.


Morphological and functional changes in isolated chloroplasts under the influence of oleate.


Reducing failure in vocational rehabilitation.


Ocular dracunculosis.

Ocular dracunculosis.


Enzymatic adaptation: molecular basis for cardiac glycoside action? 1. Increase in rat heart actomyosin and mitochondrial ATPase specific activities following digoxin injection.


Muscle spindle activity in dystonic and spastic monkeys.


Cordotomy for intractable pain of nonmalignant origin. Review of twenty cases.


Neonatal congestive heart failure as the presenting symptom of cerebral arteriovenous malformation.


Serum mucopolysaccharides in alloxan and steroid diabetes.


The liver in lipidosis. An electron miscroscopic and histochemical study.


Hyperuricemia with self-mutilation and choreo-athetosis. Lesch-Nyhan syndrome.


Effects of cystamine and cysteamine on the adenosine-triphosphatase activity and oxidative phosphorylation of rat-liver mitochondria. 1. Cystamine (2,2'-diaminodiethyl disulphide) caused an unmasking of mitochondrial adenosine triphosphatase and a leakage of Mg(2+) from the mitochondria, and decreased the stimulation of adenosine triphosphatase by 2,4-dinitrophenol. When Mg(2+) was added, cystamine potentiated the activation of adenosine triphosphatase by 2,4-dinitrophenol. 2. Cystamine was without effect on the adenosine triphosphatase of disrupted mitochondria. 3. Cystamine was moderately potent as an uncoupling agent and as an inhibitor of the [(32)P]P(i)-ATP exchange reaction. 4. Cysteamine (2-aminoethanethiol) was without the above effects, when special precautions were taken to counteract its autoxidation. 5. The effects of cystamine should probably be ascribed to its disulphide group, since the diamine cadaverine protected slightly against the loss of Mg(2+) and the decrease of 2,4-dinitrophenol-stimulated adenosine-triphosphatase activity caused by aging of the mitochondria. It is suggested that cystamine acts by a breakdown of mitochondrial permeability barriers.


The mutagenic properties of the nucleosides of pyrimidine analogues in Drosophila melanogaster.


Cardiac myofibrillar ATPase activity in hypophysectomized or thyroidectomized rats.


Report on a laminar flow surgical facility.


Controlling static in the clean room.

Controlling static in the clean room.


Kinetic evidence for multiple binding sites on phosphofructokinase.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. 8. Properties of a factor conferring oligomycin sensitivity on mitochondrial adenosine triphosphatase.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. IX. Reconstruction of oligomycin-sensitive adenosine triphosphatase.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. X. Correlation of morphology and function in submitochondrial particles.


Eight backward pupils and i.t.a.

Eight backward pupils and i.t.a.


Number work at Craig-y-Parc.

Number work at Craig-y-Parc.


A time for fresh evaluation.

A time for fresh evaluation.


An outlet after school.

An outlet after school.


Use of ultrasound in the diagnosis of pericardial effusion.


Clinico-pathological conference.

Clinico-pathological conference.


Derivatives of 2-azabicyclo[2.2.2]octane. II.


Down's syndrome with a familial D/D reciprocal translocation and a G/G chromosome.


The effect of clomiphene on hormone excretion in patients with galactorrhoea.


Metabolism of dehydroepiandrosterone and dehydroepiandrosterone sulphate by the human foetus at midpregnancy.


Distribution of some steroid sulphokinases in foetal human tissues.


Studies on Na+-K+-activated adenosine triphosphatase. XVI. Its absence from the cation transport system of Ulva lactuca.


An immunochemical study of human plasminogen and plasmin.


Mucopolysaccharides in experimental hepatic fibrosis.


Nerve implants in botulinum poisoned mammalian muscle. 1. In albino rats the botulinum poisoned gastrocnemius muscle was supplied with an accessory motor nerve in order to investigate whether muscle fibres with structurally intact but non-transmitting synapses would accept additional innervation. As a control similar operations were made in unpoisoned rats.2. One to three months after nerve implantation the muscles were examined histologically for the presence of a new end-plate zone. In botulinum treated muscles 1662 +/- 165 (mean +/- S.D.) of new end-plates were found. In the control animals only a few (90 +/- 13) were observed in the immediate vicinity of the implanted nerve trunk.3. Following recovery from the paralysing action of botulinum toxin electrical stimulation of both the implanted and the original motor nerve evoked strong mechanical twitches in the gastrocnemius muscle.4. When the nerves were stimulated simultaneously little or no summation of tension occurred, indicating that presumably many of the muscle fibres with new end-plates also had functionally intact junctions from the original nerve. The presence of two end-plates in a muscle fibre was confirmed in a few experiments on single curarized fibres by intracellular recording of end-plate potentials on stimulation of each nerve.


Reflex and cerebellar influences on alpha and on 'rhythmic' and 'tonic' gamma activity in the intercostal muscle. 1. Efferent intercostal alpha and gamma activity and afferent intercostal muscle spindle activity were studied in decerebrate cats in response to stimulation of the anterior lobe of the cerebellum and to postural and other reflexes.2. Low threshold intercostal responses were elicited from lobuli IV and V of the anterior lobe of the cerebellum.3. The existence of two functionally different types of intercostal gamma neurones has been confirmed. These are the ;rhythmic' or ;specifically respiratory' gamma neurones, and the ;tonic' gamma neurones.4. In response to cerebellar stimulation, facilitatory, inhibitory and diphasic tetanic and post-tetanic effects were obtained from alpha and the two types of gamma fibres in both external and internal intercostal nerve branches.5. Generally both inspiratory and expiratory alpha and gamma activity was facilitated in response to tetanic stimulation at contralateral stimulus sites, and inhibited in response to stimulation of ipsilateral sites.6. ;Rhythmic' gamma activity appeared to be rather closely linked to the respiratory alpha activity but the balance between ;rhythmic' gamma and alpha was often changed in response to cerebellar stimulation, as indicated by the responses of primary muscle spindle afferents.7. The ;tonic' gamma neurones were as a rule more responsive to cerebellar stimulation than were the alpha and ;rhythmic' gamma neurones. Long-lasting post-tetanic effects were much more prominent in the ;tonic' gamma fibres than in the alpha or ;rhythmic' gamma fibres.8. ;Rhythmic' gamma activity was abolished after cervical transections of the cord. ;Tonic' gamma activity remained in the spinal preparations although usually at a different discharge rate.9. ;Tonic' gamma neurones were more responsive than the ;rhythmic' gamma neurones to the proprioceptive gamma reflex elicited by passive movements of the chest wall as well as to other spinal and supraspinal reflexes.10. Both ;dynamic' and ;static' gamma fibres seem to be represented in the group of ;tonic' intercostal gamma neurones.11. The significance of the results are discussed with regard to the following two main points: (a) integration of respiratory and postural functions of the intercostal muscles; (b) cerebellar control of the alpha-gamma balance in active contractions and passive relaxations.


Relapsing polychondritis. Analytical literature review and studies on pathogenesis.


Radiocarbon cholesterol turnover in cholesterol pericarditis.


Mitochondrial membrane ghosts produced by lipid peroxidation induced by ferrous ion. II. Composition and enzymatic activity.


Interactions of epsilon-aminocaproic acid with the thrombin clotting and fibrinolytic systems.


Huntington's chorea. A multidisciplinary study of affected parents and first generation offspring.


A study of the oral toxicity of calcium chloride in dairy cows. The effects of oral administration of calcium chloride solutions to dairy cows were studied. When a 0.3 per cent solution was given ad libitum, and as the sole source of water for a period of 75 days, we observed no significant changes in feed consumption, body weight or milk production. The average daily water intake was increased by approximately 20 per cent, and signs of slight gastro-intestinal irritation were seen. No major changes in blood hemoglobin levels, hematocrits, total and differential white cell counts or thrombocyte numbers could be attributed to the treatment. We observed no significant effect on the serum calcium, chloride, magnesium, potassium, or sodium content. The level of inorganic phosphate in the serum rose to higher, but still normal values. During the entire experiment the urine pH was abnormally acid for dairy cows. Electrocardiograms were taken after 45 days of calcium chloride administration, and they appeared normal. When 0.1 and 0.2 per cent solutions were given as the sole source of water for a period of 81 days, the cows remained in good condition, and we observed no changes in appetite, body weight or milk production. In general, dairy cows will refuse to drink calcium chloride solutions when the concentration exceeds 0.5 per cent, even when they have been deprived of water for 18-24 hours. On the other hand, since the administration of lower concentrations for periods of 75 and 81 days did not cause any clinical sign of disease, it seems that on farms where more than one source of water are usually available, poisoning of dairy cattle by calcium chloride in solution is quite unlikely.


Comparative pathologic and hematologic effects in various species fed cholesterol and fats. The hematologic response in various animal species fed cholesterol and fat differed with the species and sex. Male rabbits, chickens and guinea pigs could not adequately comensate for the demand for increased red cell production and developed anemia. Female guinea pigs given added cholesterol and fat maintained adequate blood cell production but may have become anemic if the test period had been extended. Bone marrow production was increased in male rats and was sufficient to compensate for red cell loss. Blood and bone marrow values were not altered in female chickens by the dietary treatment. Fatty changes in the liver were common to all species fed added cholesterol and fat but gastric lesions were seen only in the rabbit.


The formation of plaques by African horse sickness viruses and factors affecting plaque size. Under agar overlay, large and small plaques were observed for African Horse Sickness viruses. The purification of large plaques by cloning was possible. By addition of protamine sulfate to the agar overlay only large plaques were produced. The plaque size variation can not be a suitable marker for determination of variants of this virus since under methyl cellulose and starch gel overlays homogenous plaques were noticed.


Canada's oldest veterinary practice.

Canada's oldest veterinary practice.


Genetic counseling and Down's syndrome.

Genetic counseling and Down's syndrome.


Use of carisoprodol preparations in the management of the lumbosacral syndrome.


Induced tolerance in turkeys to aflatoxin poisoning. The consumption of moderately poisonous levels of toxic groundnut meal by turkey poults induced a degree of tolerance to aflatoxin Poults thus ;conditioned' gained more than ;unconditioned' birds on successively higher levels of aflatoxin and were enabled to survive and gain on rations which killed mature turkeys. Ingestion of aflatoxin led to marked alterations in the serum electrophoretic patterns followed in a few weeks by a return to nearly normal patterns. Subsequent increases in aflatoxin intake induced only minimal alternations in the serum patterns but the tolerance appeared unrelated to the hepatotoxic effect because extensive pathological changes developed in the liver.


A note on some helminths of Manitoba chickens.


Dimethyl sulfoxide (DMSO).

Dimethyl sulfoxide (DMSO).


Exudative epidermitis in pigs. Clinical studies and preliminary transmission trials. Four outbreaks of an infectious, exudative skin disease of 6 to 10 week-old weaned pigs, are described. The disease was seen in fattening barns where weanlings from several sources were mixed. The disease was characterized in the peracute form by the formation, over the entire body, of a brown, greasy, odorous exudate, by loosening of the hoofs, by severe depression, dehydration and death in 3 to 5 days. In the acute form the lesions were identical, but their evolution slower, the mortality was high, and survivors severely stunted. Secondary infections seemed largely responsible for mortality in the acute form. Subacute infections were frequent and characterized by the formation of few to many circular exudative foci which became dry and cleared up completely in about 2 weeks. Antibiotics and mineral supplements were of no value in controlling or preventing the development of lesions or mortality.Minimal-disease pigs were exposed to diseased pigs from 3 of the 4 outbreaks studied and in all cases they developed typical lesions and could transmit the infection to other pigs. Bacteriological examination of field and experimentally produced cases gave inconclusive results pending further study.


The chemical dimensions of a healing incision.


Properties of adenosinetriphosphatase in sub-cellular particles of mouse melanoma.


The sea climate influence on some functions of the suprarenal glands.


On the antigenic composition of diphtheria toxin and toxoid.


The late apical systolic murmur. Clinical, hemodynamic and angiographic observations.


A fatal complication of aortic valve fenestration. Coronary ostial obstruction by an engaged embolus.


The continued management of the handicapped child.


Androgenic steroid complexes with p-bromophenol.


Bangkok patients reject wheelchairs.

Bangkok patients reject wheelchairs.


A lymphocyte-stimulating factor produced in vitro.


Mucopolysaccharides of whole human spleens in generalized amyloidosis.


Inhibition of the effect of repetitive stimulation on spinal motoneurones of the cat by morphine and pethidine.


Autoimmune phenomenon in eczema seborrhoeicum.


The lifespan of red blood cells in experimental lead poisoning, studied with radioactive chromium 51-Cr.


The transmission of hog cholera virus by Trichinella spiralis larvae. Studies have been carried out to determine (a) the possible role of T. spiralis larvae in the transmission of hog cholera virus and (b) to determine the effect of elevated swine temperature on the viability of trichinae. Trichina larvae from hog cholera infected swine were freed from diaphragmatic tissue by artificial digestion. Washed and disinfected larvae transmitted hog cholera virus while the supernatant digestive fluid did not transmit the virus. Infectivity of the virus was lost when the larvae were transmitted through albino rats before administration to swine. Temperature elevation of the swine did not affect the viability of the trichinae.


Hemolytic behavior of staphylococci isolated from cows' milk. Patterns of hemolysis produced by staphylococci isolated from milk were investigated on media prepared with bovine, sheep, horse, and rabbit erythrocytes under a variety of cultural circumstances. Hemolytic patterns were sharper and easier to interpret on erythrocyte agar plates when incubated at 37 degrees C in an atmosphere containing 30% CO(2.) Alpha-hemolysin production was greatly enhanced in this environment and was not detected at times when cultures were grown in air only. This was also true of deltahemolysin but to a lesser extent. Very satisfactory identification of alpha, beta- and delta-hemolysins was obtained by streaking BEA plates with the unknown strains perpendicularly to a strain producing beta-hemolysin and incubating in 30% CO(2.) This procedure avoided use of erythrocytes of different species of origin and use of staphylococcal alpha-antitoxin. Prior action of the beta-hemolysin on bovine cells was found to completely inhibit hemolysis from alpha-hemolysin but the reverse was not true. A strain inhibiting beta-hemolysis in air failed to exhibit its antihemolytic properties for 24 hours when incubated in 30% CO(2.) Patterns of hemolysis within areas subject to multiple hemolysins were found to reflect the nature and relative strength of contributing hemolysins or antihemolysins and could be modified by the time sequence of exposure to certain hemolysins or antihemolysins.


Influence of sex on the antiproteolytic activity of rat serum.


Fractionation of acidic polysaccharides derived from a small group of chondrocytes.


Partial purification and characterization of sodium- and potassium-dependent adenosine triphosphatase from rat-heart muscle.


Unknown properties of the products of plasmin-degradation of fibrinogen and fibrin.


Occupational therapy in the field of physical disabilities.


Guidelines for a bioclean spacecraft assembly area.


Automation can be an assistive device.

Automation can be an assistive device.


Muscle spindles.

Muscle spindles.


Inhibition of fibrinolytic and thromboplastic activity by Trasylol.


Studies of staphylococcal infections. II. The role of bacteriophage type, antibiotic resistance, coagulase, and other exotoxins in infections in embryonated eggs.


Changes in psychologic test (WAIS) scores of older disabled persons during a vocational rehabilitation program.


Relation of increase in muscle mass to performance of hypertrophied right ventricle in the dog.


A Vermont program helps disabled rural homemakers.


Cardiac myosin adenosinetriphosphatase activity. Modifying factors and comparison with skeletal muscle myosin adenosinetriphosphatase activity.


Management of acne vulgaris.

Management of acne vulgaris.


Reproduction in the ferret (Mustela furo). I. Uterine histology and histochemistry during pregnancy and pseudopregnancy.


Identification of 3-beta, 17-beta-dihydroxyandrost-5-ene, 3-beta, 20-alpha-dihydroxypregn-5-ene and epiandrosterone in human peripheral blood.


Metabolism of 7-3H-dehydroisoandrosterone in patients with virilizing adrenal tumors.


Gas chromatographic-mass spectrometric studies on solvolyzable steroids in human peripheral plasma.


A handicapped patient's plea: consider the whole person.


Loss of antibiotic resistance in Staphylococcus aureus resulting from growth at high temperature.


Some pitfalls in the valuation of cardiac chamber enlargement on chest roentgenograms.


Hirschsprung's disease and mongolism.

Hirschsprung's disease and mongolism.


Congenital aortic sinus aneurysms with particular reference to dissection of the interventricular septum.


Preoperative and postoperative electrocardiogram in complete transposition of the great vessels.


The temporal sequence of lymph flow in the right lymphatic duct in experimental chronic pulmonary edema.


The challenge of research on mucus.

The challenge of research on mucus.


Clinical pathologic conference.

Clinical pathologic conference.


Acid mucopolysaccharide composition in human colon.


Tritiated thymidine uptake by group G chromosomes of female individuals with Down's syndrome.


Serum inhibitors of elastase, trypsin, and plasmin in chronic rheumatic diseases.


Fungal infection of the nails.

Fungal infection of the nails.


Cutaneous manifestations of drug toxicity.


Effect of biotin on hair roots and sebum excretion in women with diffuse alopecia.


Medical testimony in a workmen's compensation case of hiatal hernia, bilateral vagotomy, pyloroplasty, and tube gastrostomy, showing the cross-examinations of the internists, radiologist, and surgeon called by respondents (defendants).


Industrial aspects of abdominal trauma.

Industrial aspects of abdominal trauma.


Coagulation changes during experimental hemorrhagic shock. Clotting activity, contribution of splanchnic circulation and acidosis as controlled by THAM.


Laceration of abdominal aorta and study of intact abdominal wall as tamponade: report of survival and literature review.


Removal of impacted pulmonary emboli by retrograde injection of fibrinolysin into the pulmonary veins. Report of three cases and experimental studies.


The anti-seborrheic qualities of zinc pyrithione (zinc pyridine-2-thiol-1-oxide) in a cream vehicle. 1. A preliminary report.


Water fluoridation--its effect on pedodontics.


Human relations in a pedodontic practice.


Handicapped children in dental practice.


Morphological and biochemical correlates of cerebral microsomes. II. A study of the structural association of glutamine synthetase, ATPase, and an esterase acting on o-nitrophenyl acetate.


Senior dental student recognition awards for 1966.


An evaluation of 51 patients with hepatic artery infusion.


Pain control: trigeminal neuralgia--a review of etiology and treatment.


Vascular connective tissue under the influence of oestrogens. I. Biochemical and morphological studies of aortae of untreated female and male rabbits, and aortae of castrated and sham-operated female rabbits.


Job readiness: key to placement.

Job readiness: key to placement.


Myocardosis and cardiac failure in men.

Myocardosis and cardiac failure in men.


On urinary acid mucopolysaccharides in a case of gargoylism (Hurler's syndrome). A preliminary note.


Depression of afferent activity originating in muscle spindles induced by mephenesin, procaine and caramiphen.


Studies on acid mucopolysaccharides in urine. 1. On urinary acid mucopolysaccharides from patients with mongolism (Down's syndrome).


A probable case of Dracunculus medinensis (Linnaeus, 1758) Gallandant, 1773, in a dog in Pennsylvania.


Fluoridation's benefits not limited to health: some observations, some predictions.


The preparation of some 4-substituted nicotinic acids and nicotinamides.


Placental estrogen biosynthesis during human pregnancy.


Virus aetiology for Down's syndrome (mongolism).


Diagnosis of retinal detachment.

Diagnosis of retinal detachment.


Management of cervical carcinoma in the elderly patient.


Sunlight and skin. 3. Degenerative and neoplastic effects.


Electrocardiogram of the month.

Electrocardiogram of the month.


Acid mucopolysaccharides and lipids of Japanese arteries, with special reference to the absence of hyaluronic acid in Japanese cerebral artery.


Hearing measurement and hearing loss.

Hearing measurement and hearing loss.


University of Arkansas Medical Center.

University of Arkansas Medical Center.


Colles' fractures.

Colles' fractures.


Acute and chronic intestinal obstruction: the development of current concepts of management.


Arterial infusion chemotherapy of liver cancer.


Dental care for the homebound aged patient.


Vitamin C-induced increase of dermatan sulfate in cultured Hurler's fibroblasts. In fibroblasts taken from patients witli Hurler's syndromne and grown in cultlure, dermatan sulfate constituted a larger percentage of the total sulfated glycosaminoglycans than it did in cultured fibroblasts from unaffected individuals. Moreover, the addition of ascorbic acid (vitamnin C) to the culture medium markedly increased the concentration of dermatan sulfate in the Hurler's fibroblasts but not in the normal fibroblasts. The biochemical phenotype of the Hurler's cells persisted during 28 weeks of serial culture.


Work and heart disease in Wisconsin. I. Medical basis for workmen's compensation awards over ten years.


Acid mucopolysaccharide and hexosamine metabolism in dermal connective tissue of adrenalectomized rats.


Differences in variability of discharge frequency between primary and secondary muscle spindle afferent endings of the cat.


DNA synthesis and differentiation in embryonic kidney mesenchyme in vitro. Mitosis accompanies the differentiation of embryonic metanephrogenic mesenchyme in vitro. Inhibition of mitosis by 5-fluorodeoxyuridine, but not by x-rays, is associated with inhibition of differentiation. The difference may be due to the effect of 5-fluorode-oxyuridine on DNA synthesis.


The effect of restraint on the content of acid polysaccharides of glandular gastric wall in rat.


Case records of the Massachusetts General Hospital. Case 40-1966.


Combined mongolism and leukemia. Report of eight cases with chromosome studies.


Normal-21-trisomy mosaicism. Report of four cases and review of the subject.


Nature and significance of changes in the houseparent role in institutions for children.


Diagnostic significance of atrial fibrillatory waves.


Dental problems in children.

Dental problems in children.


The thrombolytic therapy of acute myocardial infarction.


New Zealand's external aid in dental health.


Diagnosis and treatment of low back pain with emphasis on the herniated disc.


Mucopolysaccharide from patients with cystic fibrosis of the pancreas. Physical and immunologic methods were used to demonstrate the presence of an apparently unique glycoprotein in stool and tissue of patients having cystic fibrosis of the pancreas. The detection of a molecular structure specific for the disease is consistent with the apparent hereditary nature of the affection.


Understanding backache, tension and fatigue.


Some observations on the caseinolytic properties of a purified, activator-free, porcine plasmin preparation.


Reaction of rabbit leucocytes to staphylococcal (Panton-Valentine) leucocidin in vivo.


The influence of time upon the inhibition of plasmin by normal, human serum.


Studies on the inhibition of plasmin caseinolysis by human serum and a method for the assay of inhibiting activity.


The epidemiology of gingivitis in children.


Urinary amino acid excretion in mongolism.


Studies on glycolysis of red blood cells in anemias. I. Congenital microspherocytosis.


The fibrinolytic enzyme system in cervical mucus. A clinical study was undertaken to assess the fibrinolytic enzyme system in cervical mucus in relation to the different stages of the menstrual cycle.  Samples of cervical mucus from 8 women in the reproductive stage were taken on different days of the cycle and tested for components of the fibrinolytic system.  The testing procedure is explained and the results graphed.  Activator was found to disappear from the mucus for 2 days pre- and post-ovulation.  Heating and freezing the mucus did not destroy the fibrinolytic activity.  Testing was conducted for the presence of such other agents as proactivator, plasmin, and plasminogen in the mucus.


The effect of premedication with chlorpheniramine on reactions to methylglucamine iodipamide.


Translocation mongolism.

Translocation mongolism.


Mucopolysaccharide excretion in patients with Hurler's syndrome, their families, and normal man.


Rosacea and acne.

Rosacea and acne.


Pharmacologic properties of bis-quaternary ammonium derivatives of m- and p- di-(2-aminopropyl)-benzene.


Histochemical identification of acid mucopolysaccharides in cat lingual glands.


On the biosynthesis of testicular steroids in vitro and its inhibition.


The proteolytic activity of citrated stored blood and some proteins of the clotting system.


A fossil human bone from Anatolia.

A fossil human bone from Anatolia.


Some factors of human gait.

Some factors of human gait.


Palmar dermatoglyphics of the Dogon and Peul of Mali.


Nucleic acid synthesis in x-irradiated thymocytes.


Treatment of seborrheic dermatitis in the Negro scalp.


Successful total correction of ventricular septal defect, diverticulum of the left ventricle, and anomaly of the thoracoabdominal wall in an 11-year-old boy with cardiac dextroversion.


Bacteriophage typing of Staphylococcus aureus using a single concentration of phage (100 x RTD).


Physicians, dentists, and children.

Physicians, dentists, and children.


Repression and the control of cyclic enzyme synthesis in Bacillus subtilis.


Histoenzymatic reactions in experimental lead poisoning in rabbits.


Interaction of streptokinase and human plasminogen. 3. Plasmin and activator activities in reaction mixtures of streptokinase and human plasminogen or human plasmin of various molar ratios.


Swelling and shrinkage phenomena in liver mitochondria. V. Permeability of the mitochondrial membrane to univalent cations: effect of Mg++.


Urokinase levels in urine after nicotinic acid injection.


Comparison of caseinolytic and fibrinolytic assays for plasmin (fibrinolysin) in "fibrinolytic agents".


The fine structure of nuclei as revealed by electron microscopy. 3. Adenosine triphosphatase activity in the pores of nuclear envelope of mouse choroid plexus epithelial cells.


Electrocardiographic and vectorcardiographic signs of left and right ventricular hypertrophy in endurance athletes.


Glenrose . . . Canada's unique school-hospital.


Presence of sodium-potassium-stimulated ATPase in boar epididymal spermatozoon.


Histochemical demonstration of sodium-potassium-activated adenosinetriphosphatase in normal and leukaemic granulocytes.


Histoenzymatic studies on the behavior of succinic acid dehydrogenase, NADH2 tetrazolium reductase, ATP-ase and alkaline phosphatase in cancer of the uterine cervix in women.


Arabic historiography as related to the health professions in medieval Islam.


Changes in reactivity of the heart to sympathetic and parasympathetic influences during prolonged compensatory hyperfunction.


Indices of blood gases compared in healthy persons and heart patients in the Tashkent climate.


The etiology and pathogenesis of pain of spinal origin.


Low back pain etiology and pathogenesis.


Epidemiologic efficacy of live influenza vaccine during 1962 outbreaks of influenza A2 and B.


Emotion and low back pain.

Emotion and low back pain.


The compensation back.

The compensation back.


Management of low back pain--the examination.


Results in surgical treatment of herniated lumbar intervertebral discs: investigation of the late results in subjects with and without supplementary spinal fusion--a preliminary report.


Macular dystrophy of the cornea. A histochemical and electron microscopic study.


Amiphenazole sensitivity with oral ulceration.


Possible genetic consequences of family planning.


Low back pain.

Low back pain.


Fungi in nails.

Fungi in nails.


A new type of spatial vectorcardiograph.


Management of disorders of the nails.

Management of disorders of the nails.


Glycoprotein and collagen metabolism in the dermis of hypophysectomized rats.


Hunter-Hurler Syndrome: clinical and biochemical study. Combined clinical staff conference at th National Institutes of Health.


Eczematous dermatitis produced by airborne molds.


A genetical study of Hirschsprung's disease; congenital intestinal aganglionosis.


Effect of pH on the kinetics of frog muscle phosphofructokinase.


Pathogenesis of urolithiasis: relation of urinary fibrinolytic activity to nondialyzable urinary solids.


Characterization of fibrinolytic activity of vascular intima.


Control of glycolysis in human erythrocytes by inorganic phosphate and sulfate.


Familial non-progressive myopathy with muscle cramps after exercise. A new disease associated with cores in the muscle fibres.


Effects of acetylcholine infused into renal artery of dogs.


Staphylococcus aureus strains in the "52, 52A, 80, 81 complex".


Formation of estrogens by hydatidiform moles in vitro.


Industrial dermatitis.

Industrial dermatitis.


Legal aspects of accidents.

Legal aspects of accidents.


Thoughts on the accessibility of places of work to disabled employees and clients.


Maternal transmission of a 21/1 translocation associated with Down's syndrome.


Urinary tetrahydrocortisone and tetrahydrocortisol in infants born of mothers treated with corticosteroids during pregnancy.


The renal excretion of ethylenediaminetetraacetate in the dog.


Skin sensitivity to phenindione. Report of a case.


Aldosterone and oxidative phosphorylation in liver mitochondria.


Herpetic whitlow.

Herpetic whitlow.


Changes in the amount of urinary androgen hormones in students during intensive intellectual work.


Effect of tetracyclines and chloramphenicol on biosynthesis in vitro. (Immunologic and histochemical studies).


Ultra-low frequency acceleration ballistocardiogram in experimentally induced myocarditis.


Methionine S35 biosynthesis under conditions of different functional strain and varying severity of the streptococcal inflammatory process.


Changes in blood glucose level induced by repeated streptococcal infections.


Changes in serum transaminases and lactate-dehydrogenase in experimentally induced myocarditis in dogs.


Transaminase activity and destructive-proliferative changes. (Experimental study).


Comparative studies of OT and RT23 tuberculin.


Effect of serotonine on circulation.

Effect of serotonine on circulation.


Comparative studies of Monrad and Mantoux tests.


The effect of spinal injury on employment in a heavy industry.


A clinical trial of rotational manipulation of the spine in back pain cases occurring in a factory.


Thin-layer gel filtration of proteins and mucopolysaccharides.


Adrenal secretion rates of C-19 and C-21 steroids before and after hypophysectomy in the pig and the dog.


The bacteriology of the gingival crevices of erupting human incisors.


Local factors of resistance in the gingival area.


Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation.


Oxidative enzyme activities in keratinizing and non-keratinizing epithelium of normal and inflamed gingiva.


The vascular supply of the periodontal membrane. An investigation of the number and size of perforations in the alveolar wall.


Function of epithelial rests as suggested by their ultrastructure.


Condylar adaptation to a change in intermaxillary relationship.


Holidays for the disabled.

Holidays for the disabled.


Current titles in periodontology.

Current titles in periodontology.


Use of nicotinic acid and/or nicotinamide in high doses to treat schizophrenia.


Palpation of umbilical cord through abdominal wall.


The Women's Memorial of World War I.

The Women's Memorial of World War I.


Making able the disabled.

Making able the disabled.


Sézary's reticulosis progressing to poikilodermia and mycosis fungoides.


General anaesthesia for children's dentistry.


A bioassay of treatment of hemorrhagic shock. 3. Effects of a saline solution, ascorbic acid, and nicotinamide upon the toxicity of endotoxin for rats.


Walker carcinosarcoma 256 in study of anticancer agents. II. Results.


Studies on the egg-membrane lysin of Tegula pfeifferi: isolation and chemical analysis of the egg membrane.


Phospholipid involvement in gastric microsomal ATPase.


Participation of thymus in acid mucopolysaccharide metabolism.


Lysogenic properties of various Staphylococcus aureus phage-types.


Industrial dermatitis--its detection and control.


Human effects of chronic, low dose radiation. Implications for adjudication of compensation claims for radiation injury.


Pesticide exposure from concentrate spraying.


Practical pointers on managing disabled patients.


Goblet cell fine structure.

Goblet cell fine structure.


Genetic recombination between alpha-toxin mutants of Staphylococcus aureus. McClatchy, J. K. (The University of Texas Southwestern Medical School, Dallas), and E. D. Rosenblum. Genetic recombination between alpha-toxin mutants of Staphylococcus aureus. J. Bacteriol. 92:580-583. 1966.-A demonstration of genetic recombination between Staphylococcus aureus nonhemolytic mutants was attempted by means of transduction. The results of two-point reciprocal transductions placed the mutants into two genetic groups. Recombination within each group was not detectable within the limits of the method, but hemolytic recombinants were obtained in transductional crosses when donor and recipient were from different groups. At least two genetic loci are therefore involved in alpha-toxin production. The 11 mutants of group II were fibrinolysin-negative. The recombinants were always found to be restored to fibrinolysin production as well as to alpha-toxin production. These data suggest the existence of a pleiotropic gene simultaneously affecting the synthesis of both alpha toxin and fibrinolysin. The nine mutants of group I were fibrinolysin-positive. Group I members are postulated to be alpha-toxin structural mutants. Three mutants were also negative for bound coagulase, but no linkage was observed between the locus controlling bound coagulase and the loci for either fibrinolysin or alpha-toxin production.


Use of tetrazolium for improved resolution of bacteriophage plaques.


Adenosine triphosphatase activity of mycoplasma membranes. Rottem, Shlomo (Hebrew University, Jerusalem, Israel), and Shmuel Razin. Adenosine triphosphatase activity of mycoplasma membranes. J. Bacteriol. 92:714-722. 1966.-Adenosine triphosphatase activity of Mycoplasma laidlawii, M. gallisepticum, and Mycoplasma sp. strain 14 was confined to the cell membrane. The enzymatic activity was dependent on magnesium, but was not activated by sodium and potassium. Ouabain did not inhibit the adenosine triphosphatase activity of the mycoplasmas, and did not interfere with the active accumulation of potassium by M. laidlawii cells. Sulfhydryl-blocking reagents and fluoride inhibited the enzymatic activity, whereas 2,4-dinitrophenol was without any effect. Membranes of M. laidlawii hydrolyzed other nucleotide triphosphates and adenosine diphosphate (ADP), but at a lower rate than adenosine triphosphate (ATP). Nucleoside-2'-(3')-phosphates, ribose-5-phosphate, glucose-6-phosphate, and pyrophosphate were not hydrolyzed by the membrane preparations. It seems that the enzyme(s) involved in ATP hydrolysis by M. laidlawii membranes is strongly bound to the membrane subunits, which would account for the failure to purify the enzyme by protein fractionation techniques. The adenosine triphosphatase activity of mycoplasma membranes resembles in its properties that of similar enzymes studied in bacteria. The mycoplasma enzyme(s) seems to differ from the adenosine triphosphatase associated with ion transport in mammalian cell membranes and from mitochondrial adenosine triphosphatase.


Fine structure of spongy degeneration of the central nervous system (van Bogaert and Bertrand type).


Employers' liability for lunch-hour injury.


Heart disease and employment. The perspective of the occupational physician.


Administration of the antimetabolite 6AN (6-aminonicotinamide) to horses.


Nervous control of the mechanical properties of the abdominal wall at feeding in Rhodnius.


Unwanted effects of propranolol.

Unwanted effects of propranolol.


Comparative placental steroid synthesis. I. Conversion of (7-3-H)-dehydroepiandrosterone to (3-H)-androst-4-ene-3,17-dione.


Catabolic metabolism of cholesterol in stomach cancer.


Histochemical studies of hydrolytic and oxidative enzymes in the human intestinal tumors.


Cardiac output in erythrodermic skin disease.


Influences of metabolic-effective agents on nucleotide systems in ocular tissues.


Exchanges of nucleotide phosphates in normal and in failing canine hearts.


Cutaneous atrophy secondary to intra-articular corticosteroid administration.


The excretion of nondialyzable urinary mucopolysaccharide in rheumatic and other systemic disease states.


Characterization of leukocyte glucose-6-phosphate dehydrogenase in normal and mutant human subjects.


Elephantiasis nostras of the abdominal wall.


Developmental highlights.

Developmental highlights.


Mucopolysaccharidosis type 3. Morphologic and biochemical studies of two siblings with Sanfilippo syndrome.


Case records of the Massachusetts General Hospital. Case 54-1966.


The sex chromosomes in evolution and in medicine. The recent emergence of human cytogenetics has a firm foundation in studies on other forms of life. Historical highlights are Mendel's studies on the garden pea (published in 1865 but lost in an obscure journal until 1900); formulation of cytogenic postulates by Sutton and Boveri (1902-1903); Bridges' discovery of chromosome abnormalities in Drosophila (1916), followed by numerous similar studies in plants; and demonstration of the chromosomal basis of the syndromes of Down, Klinefelter and Turner in man (1959).The sex chromosomes (XX and XY) evolved from a pair of undifferentiated autosomes of a premammalian ancestor, the X chromosome changing less than the Y as they evolved. Eleven numerical abnormalities of the sex chromosomes are known in man, and knowledge of their effects on development is accumulating. The abnormal complexes range in size from the XO error of Turner's syndrome to the XXXXY error of a variant of Klinefelter's syndrome.


The severely involved child: maternal backache.


LH and adrenal androgenesis.

LH and adrenal androgenesis.


National Employ the Physically Handicapped Week: when America listens.


Hire the Handicapped Week: a critique.

Hire the Handicapped Week: a critique.


Emotional factors in residential care of handicapped children.


Neutral steroid sulphation and oestrogen biosynthesis in vitro by a feminizing Leydig cell tumour of the testis.


Definitive surgical treatment of anomalous origin of left coronary artery from pulmonary artery: indications and results.


Hematoma of the rectus abdominis muscle complicated by anticoagulation therapy.


Nonphosphorylating respiration of mitochondria from brown adipose tissue of rats. Mitochondria from brown adipose tissue of cold-acclimated rats (6 degrees C) oxidize alpha-ketoglutarate at a rate twice that of controls (26 degrees C). In both groups, however, the phosphorus: oxygen ratio with alpha-ketoglutarate never exceeded unity, and it is essentially zero with either succinate or alpha-glycerophosphate. Adenosine triphosphatase activity of these mitochondria is very low and it is not stimulated by 2,4-dinitrophenol. In addition, both respiration and phosphorylation are unaffected by adenosine diphosphate, 2,4-dinitrophenol, bovine serum albumin, or glutathione. Endogenous respiration of tissue slices is not stimulated by 2-4-dinitrophenol. It is suggested that brown fat mitochondria are not capable of oxidative phosphorylation, but do phosphorylate at the substrate level. Since these findings provide an unusual example of electron transport by means of an energetically nonconservative pathway, their significance to thermogenesis by brown adipose tissue is particularly emphasized.


Electrocardiographic changes reflecting left atrial abnormality in hypertension.


The proteolysis of fibrinogen by plasmin: the identification of thrombin-clottable fibrinogen derivatives which polymerize abnormally.


The ionic requirements for the development of contracture in isolated slow muscle fibres of the frog.


Comparative pathophysiology of the paroxysmal EEG. Laminar analysis of the electrogenesis of spike and wave activity in the frog telencephalon.


Paroxysmal electrical activity in the isolated forebrain of the frog (rana temporaria). Comparative pathophysiology of the thalamic pacemaker of paroxysmal activity.


The reactibility of rats with defined susceptibility to an acoustic epileptogenic stimulus--to some acoustic and optic stimuli.


The effect of thalamic spreading depression on conduction in the visual and auditory pathways.


The effect of isoprenaline pretreatment on the size of acute myocardial necrosis induced by the same drug.


Effect of chronic systemic hypoxia of the methaemoglobin type on the rat myocardium and its resistance to anoxia.


The respiratory metabolism of liver tissue slices and the total respiratory metabolism in rats after partial hepatectomy.


Changes in the content of proteins, nucleic acids and the histological picture of the thyroid gland during the postnatal period in the rat.


Changes in erythropoiesis after whole-body x-irradiation in rats and rabbits.


The role of erythropoietin in changes of erythropoiesis after x-irradiation in rats and rabbits.


A device for measuring isometric contractions mechanoelectrically.


Supravalvular mitral stenosis associated with ventricular septal defect, subvalvular aortic stenosis and double aortic arch.


Endocardial fibroelastosis of the right ventricle in the newborn. Presenting the clinical picture of the hypoplastic right heart syndrome.


Cystinuria associated with mongolism and identification of an abnormal pyrrolidine compound in urine.


Subcellular changes in surface adenosine triphosphatase activity of human liver in extrahepatic obstructive jaundice.


Methoxychlor toxicity. Comparative studies in the dog and the swine.


Piglet birthweights and the order of farrowing. The relationship between birthweight and order of farrowing was determined from the records of 202 attended farrowings. Statistical analysis of all individual birthweights showed the first-born piglet to be heavier (P<0.05) than the last-born. The order of farrowing might not be entirely random, as further evidenced by a delayed expulsion of stillborn piglets; 70 per cent of these births occurred during the last third of the farrowing period.


Plaque formation by Teschen disease virus and the effect of certain associated factors. A plaque assay method was developed for Teschen disease virus using primary pig kidney cultures in which neutral red stain was incorporated in the agar overlay medium. Certain factors associated with the plaque-forming ability of the virus were standardized. Cultures allowed to adsorb the virus for 45-60 minutes at 28 and 37 C, gave maximal plaque count. The virus infected the cellular layer through the agar medium. Plating efficiency of the virus was enhanced by using a small volume of inoculum. Addition of serum to the medium was not required. Neutral red concentration in the agar overlay medium affected the number of plaques. Statistical analysis demonstrated the uniformity of the plaque counts and their linear relationship to virus concentration. Isolation of the virus by the plaque technique from infected spinal cord supernatant fluid was achieved.


Studies on transmissible gastroenteritis of swine. II. Selected characteristics of a cytopathogenic virus common to five isolates from transmissible gastroenteritis. Five cell culture isolates from transmissible gastroenteritis (TGE) of swine have been studied. There is a cytopathogenic virus common to all of these isolates. Some of the characteristics of this virus, such as its size, approximately 100 mmicro, its relative sensitivity to ether, lability at pH 2, pH 3, and pH 10, and its heat lability suggest that it may be a member of the myxovirus class. Concurrent research in this laboratory indicates that this cytopathogenic virus is not the only virus involved in the etiology of TGE, but it appears to be associated with many of the outbreaks of TGE which have been studied by this laboratory.


Studies of Escherichia coli in gnotobiotic pigs. I. Experimental reproduction of colibacillosis. The successful experimental production of colibacillosis in young gnotobiotic pigs by the oral administration of E. COLI (08:K.:H21 was accomplished. Colibacillosis was not produced in gnotobiotic pigs infected with either of the 2 other strains of E.COLI employed.Necropsy observations were presented and discussed. Emphasis was placed on the absence of grossly visible enteritis in pigs that died in the acute phase of the disease. The gross appearance of the intestinal tract changed some hours after death to resemble that associated with enteritis.Bacteremia was detected in the gnotobiotic pigs orally infected with each of the 3 strains of E. COLI, and the special characteristics of the colostrum-deprived pig were stressed as important factors in these findings.


Bacteria in acne lesions.

Bacteria in acne lesions.


Down syndrome and congenital leukemia.

Down syndrome and congenital leukemia.


Repair of potentially lethal damage in x-irradiated HeLa cells.


Sudden death from bronchial asthma.

Sudden death from bronchial asthma.


Erosion of the teeth.

Erosion of the teeth.


Digitonin precipitable steroids in normal human urine.


Excretion of 16-alpha-hydroxysteroids by premature infants.


Thin-layer chromatography of 17-ketosteroid 2,4-dinitrophenylhydrazones.


A histochemical study of polyphosphate hydrolases in epidermal dendritic cells.


Double beds and backache.

Double beds and backache.


Histochemical study of dentin in hydrocoritsone- and fluoride-treated rats.


Epiphyseal growth zones in acute lathyrism. Determinations of water, hydroxyproline and mucopolysaccharides.


The excretion of taurine during deoxypyridoxine administration in Downs' syndrome patients and controls.


Generalized aminoaciduria in the magnesium deficient rat.


Light sensitization and peroxides in sweat.


Haemagglutination inhibition by antibody to host material of fowl plague virus grown in different tissues of chick chorioallantoic membranes.


A quantitative study of muscle factors in the chronic low back syndrome.


Biochemical changes in the brain in rats poisoned with an alkymercury compound, with special reference to the inhibition of protein synthesis in brain cortex slices.


The death adder (Acanthophis antarcticus): the effect of the bite and its treatment.


The significance of cardiac murmurs in anemia.


A new practical back brace.

A new practical back brace.


Controlled relaxation. II. Clinical management of muscle-relaxant administration.


Total-skin electron-beam therapy of lymphoma cutis and generalized psoriasis: clinical experiences and adverse reactions.


Cardiovascular malformation and hydramnios.


Total anomalous pulmonary venous drainage into the azygos vein.


Adenosinetriphosphatase activity of cardiac myosin. Comparison of the enzymatic activities and activation by actin of dog cardiac, rabbit cardiac, rabbit white skeletal and rabbit red skeletal muscle myosins.


A cholera epidemic without a hospital death.


A comparison of plasma lipoprotein levels in Asians, Africans and Europeans.


Epidemiology of fractures in the Chinese children of Singapore.


An epidemiological study of humeral fractures in Singapore.


Responses of large and small intestine of the rat to cesium, 5-hydroxytryptamine ouabain and acetyl choline.


Veterinary parasitology in Malaysia with reference to cattle problems.


Progressive eradication of malarial disease in New Guinea. Experience in Maprik.


Plasmodium inui-like infection producing a presumably fatal illness in a leaf monkey Presbytis johnii--a previously undescribed host.


Separation of P. Berghei antigens by disc electrophoresis.


Haemagglutination tests in malaria and toxoplasma: observations on sedimentation patterns.


The application of fluorescent antibody test to Balantidium coli using fluorescent isothiocyanate and rhodamine isothiocyanate.


A demonstration of the use of the polygraph to record Schultz-Dale reactions utilizing sera of monkeys infected with Brugia malayi as sources of both antibody and antigen.


A note on the preferred A. aegypti breeding habitats in urban areas in Malaysia.


Development of Wuchereria bancrofti in the domestic cat.


Studies on filariasis in New Guinea. Observations on periodicity.


A note on an egg parasite of Megymenum subpurpurascens West (pentatomidae: Rhyncheta).


A double infection of filariasis in a black panther (Panthera pardus) from Pahang.


A new filarial worm in the heart of a forest rat (Rattus sabanus).


A sheathed microfilaria from a tree-shrew (Tupaia glis).


Ascaris lumbricides eggs in liver and lungs of 2-year-old boy at necropsy. Confirmation by experimental inoculations of animals.


Comparison of developmental rates of two strains of Angiostrongylus cantonensis in the same laboratory-bred final hosts.


Comparative susceptibility of primitive and higher primates to infection with Angiostrongylus cantonensis (Nematoda: Metastrongylidae).


Studies on Stephanofilaria kaeli in cattle.


Histopathology of Stephanofilaria kaeli lesions in cattle.


A study of the Nematode parasites of cockroaches in Singapore.


Demonstration of a Nematode, Muspicea Sp., from the skin of laboratory mice.


Possible sources of human infection with Opisthorchis and Paragonimus in Malaya.


Life cycle of a new Plagiorchid from Bulbuls and Swifts experimentally maintained in White-headed Munias and white mice.


Differenation of Trematode cercariae of the Genus Plagiorchis by use of the patterns of their argentophilic cuticular structures.


Miracidial maze. Use of a free-choice system to test Echinostome miracidia in their relative attraction towards normal and abnormal snails hosts, living, dead, whole, and dissected snails.


Lung infection of rat with Cysticercus fasciolaris.


A Malayan record of Temnocephala semperi Weber (Rhabdocoela, Temnocephalidae), an ectocommensal turbellarian on the freshwater crab Potamon rafflesi Roux.


Ambulation of "ambulatory" handicapped patients.


Hurler's syndrome. Effect of retinol (vitamin A alcohol) on cellular mucopolysaccharides in cultured human skin fibroblasts. Skin fibroblasts from eight families with Hurler's syndrome (X-linked recessive and autosomal recessive) and normal individuals have been studied in cell culture. A good correlation between cellular metachromasia and the quantitative estimation of intracellular mucopolysaccharides was observed provided the culture conditions were standardized. In both forms of Hurler's syndrome intracellular mucopolysaccharide content could be used to distinguish the affected individual and the carrier from the normal subject, although the total mucopolysaccharide content of fibroblast cultures or the amount in the culture medium did not permit such a distinction. Retinol, in concentrations similar to those encountered in man in hyper-vitaminosis A, caused a reduction in total mucopolysaccharide content of fibroblast cultures from normal and affected individuals. Cultures from three patients with the X-linked recessive form of Hurler's syndrome showed a gradual but marked decrease in cellular metachromasia and approximately 60% decrease in mucopolysaccharide content. Synthesis of polysaccharides and sulfation appeared to be equally affected. On removal of retinol from the medium the content of intracellular mucopolysaccharides returned to pretreatment levels. The possible relevance of these findings to the treatment of Hurler's syndrome is discussed.


The response of various skin lesions to oral sulfur--35.


Ultrastructure of myocardium in physiological hypertrophy of the heart in rats.


Concentrations of amino acids in plasma and muscle. Relationship to androgen metabolism during growth and development in the male.


Spontaneous atlanto-axial dislocation in a mongoloid child with spinal cord compression. Case report.


The return of the injured worker to work.


Effect of adrenal steroids on a Na+- and K+-requiring adenosine triphosphatase from rat kidney.


The plasmin inhibitor of human plasma. IV. Its action on plasmin, trypsin, chymotrypsin, and thrombin.


Treatment of cancer patients with infusions of plasmin.


Cardiac size and pulmonary arteriography in experimental chronic hypoxia.


Cerebral oxygen consumption in Down's syndrome.


Some general observations on the usefulness of lysergic acid in psychiatry.


Pathologic physiology of valvular regurgitation.


The first appointment.

The first appointment.


Children's dentistry--present and future trends.


Health or medical questionnaire.

Health or medical questionnaire.


Idiopathic and disseminated eczema.

Idiopathic and disseminated eczema.


Steroid hormone transformations by endocrine organs from pregnant mammals. I. Estrogen biosynthesis by mammalian placental preparations in vitro.


Crystallization and properties of rabbit skeletal muscle phosphofructokinase.


In vivo parathyroid hormone status as related to respiration, phosphorylation and ion transport in rat kidney mitochondria.


Further analysis of the mode of inhibition and activation of Novikoff ascites tumor phosphofructokinase.


The determination of urinary androsterone, etiocholanolone, and dehydroepiandrosterone in the normal male rhesus monkey.


Catalysis of the direct transfer of oxygen from nicotinamide N-oxide to xanthine by xanthine oxidase.


Studies on Southeast Asian Haemaphysalis ticks (Ixodoidea, Ixodidae). Species described by Supino in 1897 from Burma, with special reference to H. (Rhipistoma) asiaticus (= H. dentipalpis Warburton and Nuttall).


Trasylol.

Trasylol.


Mitral valve replacement in a child during active rheumatic carditis: successful management of sixteen episodes of ventricular fibrillation.


Metabolic factors in the cardiac insufficiency of arteriovenous fistula.


Alzheimer's disease in late adult life.

Alzheimer's disease in late adult life.


Giant left atrium as a cause of dysphagia.


On the question of obstruction in idiopathic hypertrophic subaortic stenosis.


Sexual impotence in men having low-back syndrome.


Clothing for the handicapped.

Clothing for the handicapped.


The experimental approach to the treatment and upbringing of handicapped children.


Giant T wave inversion.

Giant T wave inversion.


Post-traumatic neurosis in industry.

Post-traumatic neurosis in industry.


Current Wisconsin legal concepts in industrial psychoneurosis.


The problem from the standpoint of the physician.


Responsibilities of the physician in workmen's compensation cases.


Hemodynamic fndings in acute glomeruloenphritis.


Hepatopexy for chronic cirrhotic ascites.


Aldosterone and sodium-potassium-dependent ATPase activity of rat kidney membranes.


Extraction of contractile proteins from myofibrils prepared by rate-zonal centrifugation.


Unusual dermatoglyphics associated with major congenital malformations.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 53-1966.


Degenerative joint disease of the lumbar spine in coal miners--a clinical and x-ray study.


Ankylosing spondylitis with widespread arteritis.


Oscillations of glycolytic intermediates in yeast cells.


Induction in Escherichia coli 15 of the colicinogenic factor by thymine-less death.


Comparative studies of the MG activated ATPase activity and Ca uptake of fractions of white and red muscle homogenates.


Studies on cytotropism in animal viruses. 3. Growth of influenza virus in epithelial-like and fibroblastic cells derived from chick embryo lung. Stewart, Robert B. (University of Rochester, Rochester, N.Y.), and Paul H. Frickey. Studies on cytotropism in animal viruses. III. Growth of influenza virus in epithelial-like and fibroblastic cells derived from chick embryo lung. J. Bacteriol. 92:972-977. 1966.-Growth of the PR8 strain of influenza virus was studied in epithelial-like and fibroblastic cell cultures derived from chick embryo lungs. The cells were found to differ in morphology, staining characteristics, and in their ability to support production of infectious influenza virus. Fibroblastic cells were characterized by their spindle shape, content of a mucopolysaccharide, their relative inability to synthesize infectious influenza virus, and production of a cell-associated noninfectious hemagglutinin. Epithelial-like cells were characterized by their polygonal shape, absence of mucopolysaccharide, and ability to synthesize infectious influenza virus.


The Mg2+--influence on the antibody biosynthesis in vitro inhibited by tetracyclines and chloramphenicol.


Inquiries into the insulin influence on the respiration and the synthesis of adenosine triphophate in cell nuclei isolated from thymus glands of calves.


On infections of tonsillar and odontic origin in the etiopathogenesis of experimental streptococcal myocarditis.


Disturbances in the intensity of protein synthesis when the organism repeatedly comes into contact with streptococcal infection.


Inquiries into the tuberculin sensitivity among medical students.


Fibrinolytic and thrombolytic therapy.

Fibrinolytic and thrombolytic therapy.


On the efficiency of the aqueous and alcoholic methods of morphine and strychnin extraction from visceral parts, when mixed with animal charcoal.


Assay of antibody production by surviving cells dispersed in agar gel.


An unusual abdominal flap.

An unusual abdominal flap.


The influence of bilirubin on oxidative phosphorylation and related reactions in brain and liver mitochondria: effects of protein-binding.


Spontaneous functional closure of symptomatic atrial septal defects.


The distribution of hydroxysteroid dehydrogenase in human sebaceous glands.


Mucopolysaccharides in mast cells.

Mucopolysaccharides in mast cells.


Glycolytic control mechanisms. II. Kinetics of intermediate changes during the aerobic-anoxic transition in perfused rat heart.


Some early findings on the possibility of using Aedes togoi as a vector of Dirofilaria repens in the laboratory.


The "Innenkorper" in differentiation between the microfilanriae of Brugia pahangi and B. malayi (sub-periodic form).


A filarial parasite from the flying fox (Pteropus vampyrus).


Congenital cataract.

Congenital cataract.


The Nadi reaction and mental subnormality.


Historical background of injury as it relates to the workmen's compensation law.


Current concepts of injury under the workmen's compensation act--the problem from the standpoint of industry.


Some bioelectrical properties of Amoeba proteus.


A study of maternal age in Down's syndrome.


Urinary acid mucopolysaccharides in mastocytosis. A new technique for quantitative estimation.


Diagnostic value of phlebography in venous disorders of the lower extremity.


Clot lysis with fibrinolysin: progress report.


On the possible rôle of the thyroid in the control of the development of the mammalian brain.


Observations on the spine in mongoloidism.


"Collagen disease" due to carbamazepine (Tegretol).


Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. II. Influence of various factors on sensitization to NEO.


Toxoplasmin sensitivity: subnormality and environment.


Effects of maternal age and birth order on the risk of mongolism and leukemia.


Light absorbance changes in pure mitochondria and other particulates of rat brain.


Studies on oestriol synthesis from dehydroepiandrosterone sulphate in human pregnancy.


Vascular connective tissue under the influence of oestrogens. II. Reaction of the aortic wall to noradrenaline-induced injury in female and male rabbits.


Myocardiopathy in Chagas' disease. I. Comparative study of pathologic findings in chronic human and experimental Chagas' myocarditis.


Clinical pathologic conference.

Clinical pathologic conference.


Vasoinhibitory action of proteolytic enzyme inhibitors in the capillary bed.


The birth of mongoloids.

The birth of mongoloids.


Studies on the adenosine triphosphatase activity of 14 S and 30 S dynein from cilia of Tetrahymena.


Stimulation of cerebrospinal fluid production by low doses of intraventricular ouabain.


Absence of effects of cardiac glycosides on cardiac myosin and A Ca++-sensitive reconstituted cardiac actomyosin.


Work and heart disease in Wisconsin. II. Workman's compensation rules of practice.


Histochemical investigation of ischemic villi in the placenta.


The fibrinolytic enzyme system in the newborn.


Control of the activity of highly purified cardiac actomyosin by Ca2+, Na+ and K+.


An epidemiological assessment of bundle-branch block.


Hematoma of the rectus abdominis muscle during anticoagulant therapy.


Left atrial volume and its changes in heart disease.


Biochemical changes in phytohemagglutinin stimulated human lymphocytes.


The fine structure of the basal cell of human prostate.


Immunochemical studies of the circulating products of fibrinogenolysis in certain pathological conditions.


An electromyographic diagnostic screening test in McArdle's disease and a case report.


Steroid mediated changes of leucocyte alkaline phosphatase activity in Down's syndrome.


Clinical definition of the Hurler-Hunter phenotypes. A review of 50 patients.


Long bone growth in Down's syndrome.

Long bone growth in Down's syndrome.


Continuous oscillations in a cell-free extract of S. carlsbergensis.


Red cell membrane ATPase: radiation inactivation estimates of "size".


Disorders of the hair and scalp.

Disorders of the hair and scalp.


Sensitization, immunological tolerance and desensitization of guinea pigs to neoarsphenamine. I. Sensitization to NEO. Overall results and experiments on the skin testing technique.


Chromosomal mosaicism and Down's syndrome.


Cultural characters of a newly recognized group of hospital staphylococci. Members of a newly recognized group of hospital staphylococci, which are believed to have arisen from 83A staphylococci by lysogenization, differ from them in several cultural characters. Some but not all of these characters appear to be determined by the carriage of phage.


Coxsackie group B fatal neonatal myocarditis associated with cardiomegaly. Most fatal cases of Coxsackie group B neonatal myocarditis have been associated with nursery epidemics. Occasional sporadic cases have been reported, mainly from the U.S.A., and a further case with gross cardiomegaly is described.


Dental management of the mentally retarded child.


Specificity of Rv6 greater than Rv5 in the electrocardiographic recognition of left ventricular hypertrophy.


Cerebral-palsied children respond well to treatment.


A survey of pediatric dentistry provided by Negro dentists in Texas.


Dynamics of rheumatoid joint.

Dynamics of rheumatoid joint.


Feulgen cytophotometric DNA determinations on human hearts.


Specialization and the physiatrist. Sixteenth John Stanley Coulter Memorial Lecture.


An analysis of impulse discharges from the spindle receptor.


Isolation and characterization of a phosphorylated intermediate in the (Na+ + K+) system-dependent ATPase.


Some observations on the electrical activity in the cardiac muscle fiber of horseshoe crab.


Oxygen uptake in squirrel monkeys (Saimiri sciurea).


Establishment of a caesarean-derived, gnotobiote foster nursed inbred mouse colony with observations on the control of Pseudomonas.


Rana pipiens: health and disease.

Rana pipiens: health and disease.


Restraining harness for dogs in metabolic studies involving radioactive materials.


Pseudomonas aeruginosa infection in rats used in radiobiology research.


A method for determining expected parturition date of rhesus monkeys, (Macaca mulatta).


Epidemiology of Staphylococcus aureus amongst New Guineans in the Gazelle peninsula.


Effects of peracetic acid used in gnotobiotics on experimental animals.


The role of hormones in acne.

The role of hormones in acne.


A study of heart disease in the Mulago hospital, Kampala, Uganda.


Studies on myosin from red and white skeletal muscles of the rabbit. I. Adenosine triphosphatase activity.


A contribution to the differential diagnosis of Hurler's disease and forms of Morquio's syndrome.


Familial Mongolism; with leukaemia in one member and a normal twinsib in another.


Nebraska State Medical Association officers and committees.


Impressions of the National Health Plan in Scotland and England.


The diagnosis and treatment of contact dermatitis.


Mortality patterns of middle-aged whites in Nebraska.


Oxytocic infusion for induction and augmentation of labor.


The use of embolectomy and thrombectomy catheters to relieve acute arterial and acute venous occlusion.


Occupational dermatoses.

Occupational dermatoses.


The three R's of industrial injuries--rapport, rehabilitation, and reports.


Workmen's compensation--a paradox.

Workmen's compensation--a paradox.


Heart trauma.

Heart trauma.


Psychiatric disability--fake or fact?

Psychiatric disability--fake or fact?


A thirty-nine year old woman with a five year illness involving multiple organs.


Diazepam in backache. A double-blind controlled trial.


Designing a public convenience for the disabled.


Studies on the mechanism of cellular death. 3. Changes in proteins and connective tissue elements during early and late cardiac necrosis.


Long-term results of valvuloplasty for mitral insufficiency in children.


Subcellular particles in echinoderm tube feet. I. Class asteroidea.


Effect of glucose on the level of glycolytic enzymes in yeast.