Coacervate systems and origin of life.

Coacervate systems and origin of life.


Modification of radiation-induced genetic damage in Drosophila melanogaster male germ cells with nucleic acid precursors. 3. Effects on the premeiotic cells.


Differences in the mother-infant relations of squirrel monkeys housed in social and restricted environments.


Social preferences of mother and infant squirrel monkeys following different rearing experiences.


The development and diversification of Precambrian life.


Virulence of Pseudomonas aeruginosa and spontaneous spread of pseudomonas pneumonia in a mink ranch. Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No. 5, moderately virulent for mice) was 5.5 x 10(6). By planting droplets of P. aeruginosa suspension on the mink in the wire cages, an enzootic lethal pneumonia was brought about in a ranch. This disease spread to the neighboring 12 mink in turn, in one direction, with new cases occurring every day or every other day for 13 days.


Mycobacterial components responsible for the induction of a chronic immunological inflammatory response in rabbit lungs. Fractions of the tubercle bacillus were examined for their capacity to produce an allergic pulmonary granulomatous response in rabbits. We found that emulsions containing old tuberculin and even old tuberculin alone in an emulsion could induce a pulmonary inflammatory reaction comparable in intensity to that produced with killed BCG. Emulsions lacking old tuberculin failed to produce an allergic pulmonary inflammatory response. The significance of these results in relation to immunological and nonimmunological chronic inflammation is discussed.


T cell dependence of macrophage activation and mobilization during infection with Mycobacterium tuberculosis. Mice made T cell-deficient as adults by thymectomy and lethal irradiation, and infected with Mycobacterium tuberculosis, showed a greatly reduced capacity to develop nonspecific resistance to challenge with a heterologous bacterium. The capacity to develop nonspecific resistance was restored, however, by an infusion of syngeneic thymocytes. Evidence was presented which showed that the capacity of mycobacteria-infected mice to resist a lethal challenge with a heterologous organism rested on the capacity of macrophages existing at the time of challenge to reduce the number of challenge organisms to a sublethal level within 8 h. This antibacterial activity of macrophages was substantially reduced in T cell-deficient mice but could be restored by an infusion of syngeneic thymocytes. It was concluded that T cell-deficient mice have a reduced capacity to mobilize and activate macrophages because of their reduced capacity to respond immunologically to antigens of M. tuberculosis.


Phagocytosis of live versus heat-killed bacteria by human polymorphonuclear leukocytes. Heat-killed Pseudomonas aeruginosa are phagocytized much more slowly by human polymorphonuclear leukocytes than are the live organisms. The post-phagocytic increase in hexose monophosphate shunt activity (HMS) parallels the ingestion of the bacteria. The addition of serum to the live organisms causes a marked increase in both ingestion and cellular HMS activity; serum actually causes an inhibition of both uptake and HMS activity when added to the heat-killed organisms. Differences in postphagocytic HMS activity between live and heat-killed organisms were observed with three different species of bacteria, indicating that the phenomenon is not restricted to P. aeruginosa. These data emphasize that the influence of the particle on the phagocytic process is considerable.


Immunity to Candida albicans induced by Listeria monocytogenes. Immunity to Candida albicans was studied in Swiss-Webster white female mice. Lethal and sublethal infections with C. albicans did not enhance immunity to a subsequent Listeria monocytogenes challenge. Mice sensitized to L. monocytogenes and then challenged with C. albicans intravenously were able to reduce the population of C. albicans in their kidneys after being boosted (rechallenged) with L. monocytogenes. However, the acquired cellular immunity so induced was very short-lived. Both C. albicans-sensitized and nonsensitized control mice showed an immediate-type and delayed-type skin test response to the cell wall antigen(s) of C. albicans but not to the cytoplasmic antigen(s). There did not appear to be any correlation between increase in skin test response and progression of the candida infection in mice.


Purification and antigenicity of an M-like protein of Streptococcus equi. A cell wall component of Streptococcus equi analogous to the M protein of group A streptococci has been identified and purified. A highly purified product has been obtained from cells by hot acid extraction, followed by acid precipitation, ammonium sulfate fractionation, and column chromatography. This product reacts with S. equi antiserum. The existence of this fraction in S. equi has been confirmed by the failure of trypsin-treated cells and their extracts to remove the long-chaining capacity of S. equi antiserum. The antigenicity of this M-like protein when incorporated in adjuvant has been assessed in rabbits and horses. In the rabbit, multiple doses of as low as 10 mug resulted in the production of serum capable of inducing long-chain formation and opsonizing and mouse protective antibody. Two doses of 100 mug elicited similar responses. The bactericidal capacity of this serum could be eliminated by absorption with whole S. equi cells or their extracts, but not by absorption with trypsin-treated cells or extracts therefrom. Horses vaccinated 15 months previously with a whole-cell killed vaccine and given 200 mug of the purified protein intramuscularly showed evidence of an anamnestic response to the antigen.


Insect immunity. I. Characteristics of an inducible cell-free antibacterial reaction in hemolymph of Samia cynthia pupae. Pupae of the silk moth, Samia cynthia, were found to contain an inducible antibacterial activity in their hemolymph. This immunity response was provoked by primary infections with either Escherichia coli K-12 or Enterobacter cloacae. In both cases the antibacterial activity was directed chiefly towards E. coli. During standard conditions, 1% of hemolymph could kill 10(3) to 10(4) viable E. coli, strain D31, within 5 min. A lower level of antibacterial activity was induced by injections of a sterile salt solution. The killing of strain D31 followed single-hit kinetics, and increasing rate constants were obtained for increasing amounts of hemolymph. The reaction was sensitive to pretreatment with trypsin and it was protected by reducing agents. The activity was inhibited by microgram quantities of lipopolysaccharide (LPS) prepared from certain LPS mutants of E. coli K-12. A comparison of the susceptibility showed that "heptose-less" LPS mutants were more sensitive to killing than other strains. During standard conditions hemolymph will lyse both E. coli and Micrococcus lysodeikticus. Lysis of E. coli followed a multi-hit kinetics and it was inhibited by LPS, whereas lysis of M. lysodeikticus was unaffected by LPS. Hemolymph was fractionated on Sephadex G-200, and the lytic activities were recovered in partly overlapping peaks. Reconstitution with pooled fractions gave synergistic effects with the killing assay.


Slime of Pseudomonas aeruginosa: in vivo production. Indirect hemagglutination inhibition tests were employed to detect slime in concentrations as low as 1 mug/ml. Increasing concentrations of slime resulted in proportionately greater inhibition of hemagglutination. Peritoneal aspirates and plasma of mice injected with slime were shown to exhibit the inhibitory activity of slime. The rapid dissemination of slime into the peripheral circulation was also indicated by the hemagglutination of mouse erythrocytes by specific anti-slime serum. By similar methods, the inhibitory activity of slime was also detected in peritoneal aspirates and plasma of mice infected with lethal doses of viable Pseudomonas aeruginosa. Furthermore, the inhibitory activity was found to increase with time after viable cell infection, whereas such increases were not detected after the injection of heat-killed organisms. Ferritin-labeled slime antibodies were found to completely surround cells of Pseudomonas aeruginosa obtained from the peritoneal cavity of mice 5 h postinfection.


Fish rhabdovirus replication in non-piscine cell culture: new system for the study of rhabdovirus-cell interaction in which the virus and cell have different temperature optima. The replication of three rhabdoviruses associated with diseases of fish has been demonstrated in cells of continuously cultivated non-piscine cell lines. Spring viremia of carp (SVC) virus and the salmonid fish viruses, Egtved and infectious hematopoietic necrosis virus, all replicated in mammalian WI-38 (human diploid cell strain) and BHK/21 cells and in cells of one or more reptilian cell lines at the temperatures commonly used to propagate these viruses in fish cells. The infections were cytopathic: SVC virus plaque assays may be performed in several types of mammalian cell culture. "Autointerference" apparently mediated by abortive "T" particle formation was observed during serial nondiluted passages of SVC virus in BHK/21 and TH1 cells, but not in RTG-2 or WI-38 cells. Optimal temperatures for replication of SVC and Egtved viruses in BHK/21 cells were identical to those determined in poikilothermic vertebrate cell cultures. However, these viruses replicated relatively more efficiently at suboptimal temperatures in "cold-blooded" vertebrate cells than in the hamster cells. Studies of [(3)H]uridine incorporation into uninfected BHK/21 cells incubated at different temperatures revealed that [(3)H]uridine uptake is sharply reduced at temperatures below 24.5 C. Growth curve studies of SVC virus in BHK/21 cells incubated at 23 C revealed that a clear-cut large excess of virus-induced [(3)H]uridine incorporation could be demonstrated in the absence of actinomycin D. Actinomycin D treatment (1 mug/ml) led to efficient inhibition of control cell [(3)H]uridine uptake, but also markedly reduced the total counts per minute of virus-induced [(3)H]uridine uptake, without depressing the yield of released infectious virus. Actinomycin D added to SVC virus-infected BHK/21 cell cultures at concentrations as low as 0.01 mug/ml caused a significant decrease in the level of virus-induced [(3)H]uridine uptake, despite the fact that this concentration is insufficient to efficiently suppress "background" cellular [(3)H]uridine incorporation.


Ultrastructural studies of Rickettsia prowazeki from louse midgut cells to feces: search for "dormant" forms. An electron microscope study of infected human louse gut cells and feces was made to determine whether a valid correlation exists between the increased resistance of Rickettsia prowazeki (in the louse feces) to adverse environmental influences and changes in the organism which might be reflected in its ultrastructure. Upon fine structural examination of this intracellular parasite as it passed from the louse midgut cell to the feces, it was apparent that no such morphological changes had occurred.


Immunodiffusion analysis of membranes of Thermoplasma acidophilum. Isolates of Thermoplasma acidophilum were divided into serological groups based on immunodiffusion studies of solubilized-membrane preparations.


Interferon induction in mice by lipopolysaccharide from Brucella abortus. Endotoxin or lipopolysaccharide isolated from Brucella abortus (strain 456) produced a typical endotoxin-type interferon response in mice with peak levels of the inhibitor occurring 2 h after intravenous injection of the stimuli. Brucella lipopolysaccharide was a much less effective interferon stimulus than the lipopolysaccharide isolated from Salmonella typhimurium (strain LT-2).


Pectinase activities in some fungi.

Pectinase activities in some fungi.


Isolation and characterization of ribosomes from Streptomyces griseus spores.


Observations on the reproducibility of the bromelised test cell anti-D assay using the auto-analyser.


Blood-group-like substances in some marine invertebrates. I. Blood-group A reactive substances in the ascidian Phallusia mammilata (Cuvier) and in the lancelet Amphioxus (branchiostoma) lanceolatus (Pallas).


Efficiency of anti-D IgG prevention after induced abortion. A study was conducted to investigate the efficacy of anti-D immunoglobulin prevention after induced abortion.  Serological data of Rh(D)-negative women whose pregnancies were terminated and who were given anti-D IgG in 1971 and 1972 in Hungary were compiled.  During the 2 years, a total of 8986 women undergoing abortion were given anti-D IgG.  Among these were 2419 primigravidae.  Of these, subsequent serological tests could be performed in 1588.  At the 3- and 6-month control examinations anti-D IgG could be demonstrated in 4 patients.  The figure amounts to a failure rate of .25%..  2 of the 4 patients proved to be positive only by the papain test.  When using the risk figures reported in the literature, it was determined that anti-D prophylaxis diminishes immunization of the abortion recipient to about 1/20.  It is concluded that results of the prophylaxis and the observation that 38% of the women undergoing induced abortion are young justify the opinion of those who advocate administration of anti-D in induced abortion.


Bone growth in protein calorie malnutrition.


Protein-calorie malnutrition in children and its relation to psychological development and behavior.


Blepharmone: a conjugation-inducing glycoprotein in the ciliate blepharisma. Gamone 1 of Blepharisma intermedium was isolated, identified as a slightly basic glycoprotein (mizoleclular weight, 2 x 10(5)), and designated as blepharmnone. At the concentration of 6 x 10(-8) milligram per milliliter, it specifically transforms matinig type 2 cells, so that they can conjugate in about 2 hours.


Initiation of the transcription of phi29 DNA by Bacillus subtilis RNA polymerase.


Effect of an epipodophyllotoxin derivative (VP 16-213) on macromolecular synthesis and mitosis in mastocytoma cells in vitro.


Two years study on sugar intolerance in Indonesian children.


Immunochemical studies on duck (Anas platyrhynchos) ovotransferrin-isolation, isoelectric fractionation and antigen-antibody reaction.


Schönlein-Henoch syndrome in a case of protein calorie malnutrition (case report).


Metabolic clearance rate of progesterone during lactation in the Rhesus monkey.


Evidence for multiple polypeptide chains in the membrane protein spectrin.


Human liver aminopeptidase. Role of metal ions in mechanism of action.


Effect of reaction conditions on the reassociation of divergent deoxyribonucleic acid sequences.


Identity of the Fc fragments of pathological and normal human immunoglobulin M.


Three-segment RNA genome of Lumbo virus (Bunyavirus).


Localized humoral immunity with particular reference to ruminants.


A new acidic protease in human seminal plasma.


The reassociation of ribosomal subunits from the muscle of normal and diabetic animals.


Dissociation of skeletal muscle ribosomes from normal and diabetic animals by initiation factors EIF-3.


Studies on anti-poly(adenosine diphosphate ribose) antibody.


Skin disinfection with ethanol, without and with additives.


Aflatoxins in mutants of Aspergillus flavus.


A radioisotope study of the vascular response to sagittal split osteotomy of the mandibular ramus.


Letter: Volumes of injections in mice.

Letter: Volumes of injections in mice.


Studies on cell adhesion in tissue culture. XV. Some effects of cycloheximide on cell detachment.


EM autoradiographic studies on polytene nuclei of Drosophila melanogaster. II. Organization and transcriptive activity of the chromocentre.


Disinfecting hydrotherapy equipment.

Disinfecting hydrotherapy equipment.


Hemispheric differences in the discrimination of line orientation.


The effects of posterior cortical lesions on eye orientation during visual discrimination by monkeys.


Cerebral dominance in monkeys?

Cerebral dominance in monkeys?


Use of syringaldazine for detection of laccase in sporophores of wood rotting fungi.


Detection of IgM heterogeneity dependent on the support medium of immunoelectrophoresis.


An assay of bilirubin UDP-glucuronyl transferase on needle-biopsies applied to Gilbert's syndrome.


Plasma cell dyscrasias (except myeloma).


An assessment of the suitability of bromocresol green for the determination of serum albumin.


Recovery from malnutrition: food preference and neophobia.


Relations of HL-A and Rh systems to immune reactivity. Joint report of the results of 'HL-A and immune response' workshop, Budapest 1972.


Production of cycloheximide by Streptomyces sp.


Serological studies on toxoplasmosis in patients with typhoid fever.


The histaminase activity of guinea-pig's plasma during experimental inflammation. II. Some properties of the enzyme.


Practical application of a simplified vitamin B12 radioassay.


Total nutrition by peripheral vein--the lipid system. A means for providing total nutrition is described in which 10% soybean oil-eggyolk phosphatide-glycerol emulsion (Intralipid) and a solution of 5% dextrose in 5% protein hydrolysate are given simultaneously into a peripheral vein, utilizing two giving sets united by a Y-connector at the needle. No ketonuria occurred, and there were no side effects from the lipid emulsion. Advantages of this system include absence of significant peripheral phlebitis, avoidance of the hazards of caval catheters, and absence of the complications of hypertonic solutions. Disadvantages include restricted forearm movement and frequent regulation of flow-rates.This system was used in 23 patients for periods of 4 to 78 days (mean 16.3 days). Weight gain and healing occurred, and all survived but one patient who died of myocardial infarction following successful surgical closure of an enterocolocutaneous fistula. The lipid system adds another method to the measures available for the management of major nutritional problems.


A comparison of nutritional gains resulting from intravenous and enteral feeding.


Coronary hypertonia and angina.

Coronary hypertonia and angina. Coronary hypertonia was observed in a patient with unstable angina. It was possible on one occasion to reproduce the clinical picture, electrocardiographic changes, lactate production and coronary hypertonia by means of atrial pacing. He had a normal left coronary arteriogram when the diffuse spasm was relieved by nitroglycerin. Therefore hypertonia (or spasm) of the left coronary artery was believed to be the cause of his variant angina with subendocardial ischemia.


Energy requirement in regenerative and atrophic processes of the liver in man and other mammals.


Myocardial viability after transient ischemia in primates.


Bacterial growth inhibition by amniotic fluid. I. In vitro evidence for bacterial growth-inhibiting activity.


Congenital lesions of the inner ear, demonstrated by tomography.


Cochlear electrical activity in noise-induced hearing lossmbehavioral and electrophysiological studies in primates.


Maternal mumps infection during gestation: observations on the progeny.


The ganglion on the internal laryngeal nerve.


Transport of lead 203 and calcium 47 from mother to offspring.


Organized labor and the prepaid group practice movement.


Response of the left ventricle to nitroglycerin in patients with and without mitral regurgitation.


On the control of gonadotropin secretion in the rhesus monkey.


Prevention of Rh-immunization in Sweden.


Management of pregnancy complicated by Rh-immunization. Review with respect to own investigations and results.


IgG levels in amniotic fluid.

IgG levels in amniotic fluid.


Elastase of Pseudomonas aeruginosa: inactivation of complement components and complement-derived chemotactic and phagocytic factors. A purified elastase from Pseudomonas aeruginosa was highly destructive for fluid-phase and cell-bound C1 and C3 and fluid-phase C5, C8, and C9. Inactivation of C4, C2, C6, and C7 by the enzyme varied from 0 to 67%. Low concentrations of elastase generated, then inactivated, a chemotactic factor from human C5 but not from C3. Higher enzyme concentrations inactivated the C5 chemotactic activity at a faster rate. Elastase treatment of sensitized pseudomonads containing cell-bound C3 reduced the phagocytic indexes of polymorphonuclear leukocytes. The data support the proposed chemopathogenic role of the elastase in generation of the characteristic non-inflammatory Pseudomonas vasculitis.


Escherichia coli gene transfer to unrelated bacteria by a histidine operon--RP1 drug resistance plasmic complex.


Complement and antibody in self-agglutinating human semen.


"Lower" gastrointestinal tract hemorrhage: new concepts based on arteriography.


Management of juvenile laryngeal papilloma: further observations.


Adaptive responses to total intravenous feeding.


Neurophysiological effects of dorsal column stimulation in man and monkey.


Multiple IgM autoantibodies in a nonhuman primate.


The inactivator of the first component of human complement (C1INA). The complex formation with the activated first component of human complement (C1) or with its subcomponents.


Structure and biochemistry of phloem-proteins isolated from Cucurbita maxima.


Neisseria meningitidis serogroup Y: incidence and description of clinical illness.


Cromolyn sodium therapy for chronic perennial asthma. A double-blind study of 40 children.


Frequency of the ocular choroid blush during arteriography.


Feather keratin--analysis of subunit heterogeneity.


The Lansing effect revisited. I. Life-span.


Pulmonary tuberculosis in free-living lechwe antelope in Zambia.


A pathogenic theilerial syndrome of cattle in the Narok District of Kenya. I. Transmission studies.


A pathogenic theilerial syndrome of cattle in the Narok District of Kenya. II. Serological studies.


East Coast Fever: field challenge of cattle immunised against Theileria parva (Muguga).


Sarcosporidiosis-a review.

Sarcosporidiosis-a review.


Effects of nutritional state and of administration of glucose, glibenclamide or diazoxide on the storage of amylase in mouse pancreas.


Identification of Neisseria gonorrhoeae in synovial membrane by electron microscopy.


Trends in disease caused by Neisseria meningitidis: 1972 and 1973.


Computerized system for stimulus generation, control, behavioral data acquisition and summary for primate visual psychophysics.


Protein deprivation in primates. 3. Cage activities and chain-pulling behavior of adult rhesus monkeys maintained on low-protein diets.


Clozapine--a new antipsychotic agent.

Clozapine--a new antipsychotic agent.


Clozapine--a potential antipsychotic agent without extrapyramidal manifestations.


A double-blind comparison of once-a-day pimozide, trifluoperazine, and placebo in the maintenance care of chronic schizophrenic outpatients.


Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease.


The severity of lactose intolerance in Indonesian children.


Double-blind study of the analgesic effect of ethoheptazine-aspirin.


A double-blind study to assess the efficacy of oral tilidine hydrochloride (W5759A)among a group of post-operative orthopedic and trauma patients.


Controlled-release potassium supplementation.


Gastrointestinal blood loss in patients receiving acetylsalicylic acid or diftalone, a new antiinflammatory drug: a comparative evaluation.


Evaluation of corticosteroids intended for use as topical anti-inflammatory drugs.


Immunopathological studies in patients with farmer's lung.


Septicaemia and meningitis caused by Neisseria mucosa varietas heidelbergensis.


The histaminase activity of guinea-pig's plasma during experimental inflammation. I. The enzyme activity.


Differentiation and medical importance of saccharolytic intestinal Bacteroides.


Mycobacterial proficiency testing in the Quality Evaluation Programs of the College of American Pathologists, 1972.


Pulmonary bacterial susceptibility in the burned rat. An in vivo model system, using the burned rat as a model of altered host resistance, was developed and studied to investigate the lung's ability to handle an aerosolized bacterial insult of either P. aeruginosa or S. aureus. Rates of lung bacterial clearance were correlated with mortality, bacteriologic and histologic results. Susceptibility of the lung to sepsis was shown to be directly related to host resistance and was significantly increased following cutaneous thermal injury. Exposure of burned, non-seeded rats to a bacterial aerosol on day one post burn resulted in a mortality of 50% (P. aeruginosa) and 11.1% (S. aureus). This mortality clearly demonstrates an increased susceptibility at day one post burn. In contrast, this susceptibility gradually decreased with time; no mortality in the burned rat when exposed on day six post burn or in the normal, unburned rat. Histologic findings correlate well with the mortality results showing a gradually decreasing severity of pneumonitis if aerosol exposure was further delayed. Lung bacterial clearance studies revealed that the initial good response of the pulmonary defense mechanisms immediately following aerosol challenge are short-lived and that a marked increase in pulmonary bacterial susceptibility occurs as early as 24 hours following thermal injury.


Pancreatic secretion in response to jejunal feeding of elemental diet. The instillation of elemental diet into the proximal jejunum of dogs results in a brisk pancreatic secretory response, but the fluid is watery and "enzyme-poor." The administration of the caloric equivalent in a standard blenderized ward diet induces pancreatic enzyme secretion. Although elemental diet does not "rest" the pancreas, the failure of these preparations to stimulate pancreatic enzyme secretion gives them a theoretical advantage as a nutritional source in the convalescent phase of acute pancreatitis.


Two-site model for human dental enamel dissolution in EDTA.


Plaque formation by mixed cultures of nonprimary plaque-forming microorganisms.


Development of antennal imaginal disks in Drosophila melanogaster by induced mosaicism. Experiments with strains y sn ++ and y sn ++; ssa.


Studies in immunodermatology. V. Basement membrane and reticulin antigens in human sera.


Effects of tetracyclines on membranous bone growth and dentin apposition in young rhesus monkeys.


Electromyography of the mandibular postural position in the rhesus monkey (Macaca mulatta).


Antagonistic effects of glutamine and histamine on in vitro lysozyme activity.


Instrumented PVP-augmented antiglobulin tests. I. Detection of allogeneic antibodies coating otherwise normal erythrocytes.


Navajo jaundice: a variant of neonatal hyperbilirubinemia associated with breast feeding.


A self control method for long term anticoagulation therapy.


Regulation of antibiotic production: catabolite inhibition and the dualistic effect of glucose on indolmycin production.


Metatropic dqarfism.

Metatropic dqarfism.


Primate red cell enzymes: glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.


Observations on precipitins against a peptidase with chymotrypsin-like activity of Micropolyspora faeni, in sera of cattle exposed to mouldy hay.


Eperythrozoon and Haemobartonella in monkeys.


Ehnanced resistance to certain infections in vitamin A-treated mice.


Augmentation of wound strength by pretreatment with epinephrine.


High levels of serum complement factors in juvenille rheumatoid arthritis.


Is chiasma determination sequential?

Is chiasma determination sequential?


Use of marrow-cancellous bone grafts in maxillary alveolar and palatal clefts.


Haemocyanin synthesis and the branchial gland of Octopus.


Biosynthesis of biopterin by Chinese hamster ovary (CHO K1) cell culture.


Ribonucleotide reductase from Euglena gracilis. A 5'-deoxyadenoslycobalamin-dependent enzyme.


The interaction of a cationic detergent with bovine serum albumin and other proteins.


Glycosphingolipids covalently linked to agarose gel or glass beads. Use of the compounds for purification of antibodies directed against globoside and hematoside.


Isolation and properties of two inhibitors of proteinase B from yeast.


Characterization of the functional activities of the subunits of 3-deoxy-D-arabinoheptulosonate 7-phosphate synthetase-chorismate mutase from Bacillus subtilis 168.


Induction of chymotrypsinogen by hydrocortisone in embryonic chick pancreas in vitro.


Diazepam inhibition of post-tetanic potentiation in bullfrog sympathetic ganglia: possible role of prostaglandins.


The effects of some drugs on an evoked response sensitive to tetrahydrocannabinols.


Small-intestinal bacterial flora in dermatitis herpetiformis.


Multilaboratory comparison of three immunodiffusion methods used for the detection of precipitating antibodies in hypersensitivity pneumonitis.


The role of vitreous collagen in platelet aggregation in vitro and in vivo.


Antianginal effects of chromonar. A combined investigation.


Pharmacokinetics of pivampicillin and ampicillin in man.


Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.


Lidocaine disposition kinetics in monkey and man. II. Effects of hemorrhage and sympathomimetic drug administration.


Biochemical effects of denervation in subhuman primate muscles.


Paraventricular "pseudotumor". A case report.


Osteoradionecrosis of the mandible resulting from external megavoltage radiation therapy.


Some applications of scintiscanning to radiation therapy.


From animals to man: metabolic considerations.


Pharmacodynamic and pharmacokinetic measurements of antitumor agents.


Unusual extraperitoneal lesions of the pelvis.


Maintenance of urinary asepsis in subhuman primates during chronic catheter drainage.


Infectious process in the lungs after intranasal challenge of white mice with Rickettsia prowazekii. A histologic immunoluminescent and electron microscopic study. The lungs of white mice given intranasal injections of various amounts of Rickettsia prowazekii were studied. Agent parasitism, mainly in the alveolar epithelium and nonciliated cells of bronchiolar epithelium, underlies the infectious process developing in the lungs. Rickettsiae may lodge in these cells without inducing both local and general alterations or a leukocyte response. After being released from the cells they inhabit, rickettsiae evoke acute exudative inflammation. The inflammation is accompanied by marked circulatory disorders, necrosis of exudate cells and vascular thrombosis, which are induced by toxic products of the agent. Polymorphonuclear leukocytes and macrophages represent the main defense mechanism of a host. They ingest and destroy rickettsial organisms. If infection runs a favorable course, phagocytes destroy the rickettsiae, and the organisms are entirely cleared from the lungs.


A perspective of Soviet blood banking.

A perspective of Soviet blood banking.


Hepatitis B virus subtypes ad and ay among blood donors in the Greater Los Angeles area.


The relation between response to hypotonic stress and the 51Cr recovery in vivo of preserved platelets.


Associations between coronary mortality and the weather, Chicago, 1967.


Significance of serum fungal inhibitory factor in dermatophytosis.


Impact of Medicaid and an OEO health center on use of dental services in an urban area.


Effects of prostaglandins on the internal and external carotid blood flow in the monkey.


Letter: Central venous catheter maintenance.


Proteolysis of preformed protein in wound nutrition.


Effect of complete parenteral nutrition including fat emulsion on plasma lipid.


An exploratory study of associate degree programs for mental health workers.


Parenteral hyperalimentation.

Parenteral hyperalimentation.


Letter: The use of nebulized Intal in asthma.


Influence of postpartum home visits on postpartum clinic attendance.


Medical costs and other aspects of dog bites in Baltimore.


Supplying health care to nondelegates during 1972 national political conventions.


The day hospitals organisation: the first 4 years.


The auditory system of the medulla and localization.


Neurophysiological mechanisms of sound localization.


Irregular reporting of tuberculosis cases by laboratories in Nassau County, N.Y.


Development of some mechanisms useful in sound localization.


Living with long-term home dialysis.

Living with long-term home dialysis.


Glomerulitis in typhoid fever.

Glomerulitis in typhoid fever.


Ethambutol in pregnancy: observations on embryogenesis.


Pulmonary allergic granulomatosis: a possible drug reaction in a patient receiving cromolyn sodium.


The use of total-body counters for the study of iron metabolism and iron loss.


Treatment of advanced tumours of head and neck with fast neutrons. Fast neutrons interact with matter in a different way from x and gamma rays. They have been used at Hammersmith Hospital for the past four years in the treatment of advanced tumours in several sites of the body, and the results of this treatment in the first 100 cases of tumours of the head and neck are described here. Altogether 62 patients who had been referred for fast neutron therapy because it was thought that no other treatment would be effective experienced complete regression of the tumours, and only two recurred. Tumours of the buccal cavity and salivary glands responded particularly well and the relief of pain and ulceration was striking. Side effects were not serious and did not differ from those seen with supervoltage radiation, apart from the reaction of the skin. Follow-up was short, however, owing to deaths from metastases, and out of 76 patients treated more than one year previously only 30 survived. Cases which have not metastasized must therefore be treated so that the effects on tumours and adjacent normal tissues can be observed for several years after treatment. The results obtained so far indicate that it is now justifiable to use neutrons in such cases.


Letter: Maternal blood group A and pre-eclampsia.


Red cell zinc and red cell zinc metalloenzymes in hyperthyroidism.


Pituitary-thyroid function after total adrenalectomy in patients with Cushing's disease.


Phenolic metabolites of DL-norgestrel: a method for the removal of 1-hydroxylated metabolites, potential sources of phenolic artifacts.


Electron microscopy of gonococci in the urethral secretions of patients with gonorrhoea treated with penicillin and erythromycin.


Immunofluorescence staining for the detection of Neisseria gonorrhoeae in women.


Modified transport and growth medium for the cultivation of Neisseria gonorrhoeae.


Sensitivity to ampicillin, penicillin, and tetracyline of gonococci in Rotterdam.


Growth and effect of mycoplasmas in Fallopian tube organ cultures.


Sexually-transmitted diseases in women.

Sexually-transmitted diseases in women.


An approach to VD control based on a study in Kingston, Jamaica.


Hepatitis B antigen in prostitutes.

Hepatitis B antigen in prostitutes.


Letter: Puerperal rubella vaccination and anti-D immunoglobulin.


Phospholipids in amniotic fluid. I. Relationship of phospholipid concentrations to gestation, maternal disease and fetal outcome.


The metabolism of (75Se)selenite in young women.


The metabolism of 14C-labelled essential amino acids given by intragastric or intravenous infusion to rats on normal and protein-free diets.


The utilization of gelled maize starch in the small intestine of sheep.


Plasma fibrinogen and its fragments during streptokinase treatment.


Pilus-dependence of four Pseudomonas aeruginosa bacteriophages with non-contractile tails.


Integrity of cell-bound poly(I).poly(C).


Modifications by sodium auro-thio-malate of the expression of virulence in mice by defined strains of Semliki Forest virus.


Screening for gonorrhea in a low-risk population.


Amniotic fluid glucose concentration.

Amniotic fluid glucose concentration.


Studies on uterine flushings in the baboon. 3. Immunochemical composition in animals with and without intrauterine contraceptive devices.


Enhancement of the IgG antibody production to Escherichia coli O antigen by prior exposure to serologically different E. coli bacteria.


Transient antigen-specific non-reactivity of an organ induced in sensitized animals by repeated challenges. A new experimental phenomenon observed in the parotid gland of rats.


Osteoclastic resorption of 3H-proline labelled bone, dentine and cementum in the rat.


Genetic control of spermiogenesis in Drosophila melanogaster: the effects of abnormal cytoplasmic microtubule populations in mutant ms(3)10R and its colcemid-induced phenocopy.


Dynamics of spermiogenesis in Drosophila melanogaster. IV. Nuclear transformation.


Chemical modification of mushroom tyrosinase for stabilization to reaction inactivation.


Seeing form.

Seeing form.


Brain damage and seeing: a new look at some old problems.


The argon laser-the effect on retinal tissues and its clinical applications.


Vortex patterns of the corneal epithelium.


Ocular brucellosis.

Ocular brucellosis.


Myocardial changes in monkeys fed mustard oil.


Long-term results of carotid artery surgery for cerebrovascular insufficiency.


Antibiotic susceptibility of gram-negative bacilli isolated from blood cultures. Results of tests with 35 agents and strains from 169 patients at Boston City Hospital during 1972.


Cell fusion induced by Germiston and Wesselsbron viruses.


Parenteral hyperalimentation.

Parenteral hyperalimentation.


Therapeutic intravenous alimentation for traumatic chylous ascites in a child.


Jaundice, hypertrophic pyloric stenosis, and hepatic glucuronyl transferase.


Human and bovine prothrombin similarities.


Power spectra of pulse sequences and implications for membrane fluctuations.


A stochastic model for chemical kinetics.


Projections from the pulvinar to the middle temporal visual area (MT) in the owl monkey, Aotus trivirgatus.


Demonstration of detergent-soluble antigen specific for the synaptosomal membrane-fraction isolated from the cat cerebral cortex.


Electrophysiological analysis of the effects of L-dopa on the reciprocal corticothalamic projections in the squirrel monkey. I. Iatrogenic coma and disinhibition of medial thalamic neurons.


Control of stable RNA synthesis in a temperature-sensitive mutant of elongation factor G of Bacillus subtilis.


Dark repair of DNA containing "spore photoproduct" in Bacillus subtilis.


Effect of supratentorial space-occupying lesions on regional intracranial pressure and local cerebral blood flow: an experimental study in baboons. Cortical blood flow and epidural intracranial pressure have been measured in the two supratentorial compartments of the intracranial space in experimental baboons during the acute expansion of a parieto-occipital epidural balloon. Differential pressures between the two halves of the supratentorial space have been found, and these have been associated with evidence that flow has fallen more quickly in the hemisphere most compressed. The evidence points to a more rapid exhaustion of the autoregulatory capacity in the hemisphere subjected to greater compression, a fall in perfusion pressure to below critical autoregulatory levels occurring slightly before that in the opposite hemisphere, and the establishment of a differential flow pattern for a short time during a critical phase of compression. The displacements induced by inflation of the parieto-occipital balloon have been described.


Inactivation of 6-phosphogluconate dehydrogenase structural gene of Drosophila melanogaster caused by translocation to heterochromatin.


Tuberculous meningitis as a complication of sarcoidosis. In two patients with well established sarcoidosis, the acute onset of meningitis proved to be due to tuberculosis rather than to an extension of sarcoid granulomata to the meninges. The cerebrospinal fluid changes are very similar, and the differential diagnosis rests on a search for Mycobacterium tuberculosis.


Muscle blood flow in Duchenne type muscular dystrophy, limb-girdle dystrophy, polymyositis, and in normal controls. Muscle blood flow (MBF) was measured using the local (133)Xenon injection method in patients with Duchenne type muscular dystrophy (six), limb-girdle dystrophy (four), polymyositis (seven), and in normal controls (11). Measurements were made at rest and during hyperaemia induced by ischaemic exercise and by histamine injection. Capillary diffusion capacity was measured with the (51)Cr-EDTA method in three patients with Duchenne dystrophy and in six normal controls. Patients with Duchenne dystrophy had normal MBF during rest and during hyperaemia after exercise and significantly increased MBF after histamine injection. The capillary diffusion capacity was higher than normal, but not significantly. In limb-girdle dystrophy MBF was normal, while in polymyositis it was significantly decreased in all three circulatory states. The relevance of the findings to the proposed ischaemic aetiology of Duchenne dystrophy is considered.


Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man. Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.


Two cases of hepatic mastocytoma in sheep.


Giant cell aortitis in a South American monkey (Callimico goeldii).


Endometriosis in four irradiated rhesus monkeys.


Letter: Osteitis deformans in a macaque.


Chronic eosinophilic myositis in a rhesus monkey infected with sarcosporidiosis.


A new genus of late oligocene monkey (Cebidae, Platyrrhini) with notes on postorbital closure and Platyrrhine evolution.


Ecological relations and niche separation between sympatric terrestrial primates in Ethiopia.


A ten-year summary of reproductive data for free-ranging Macaca mulatta.


Nucleus ventroposterior inferior (VPI) as the ventibular thalamic relay in the rhesus monkey. I. Field potential investigation.


Complement-induced changes in the core structure of sheep erythrocyte membranes: a study by freeze-etch electron microscopy.


Purification and kinetic mechanism of rat liver glycogen synthase.


Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of Mycobacteria.


Phasic myocardial blood content. An experimental study on effects of hypoxaemia, ischaemia and coronary drugs.


Hematology of laboratory baboons in Kenya.


Chromosome banding patterns in squirrel monkeys (Saimiri sciureus).


Serum thyrotropin during daily life and in response to thyrotropin releasing hormone in normal subjects and juvenile diabetics.


Comparative metabolism of drugs in man and monkeys.


Relationship between plasma corticosterone and the development of ketoacidosis in the alloxan diabetic rat.


FSA-foetal sulphoglycoprotein antigen associated with gastric cancer.


Comparative sensitivity of gel-diffusion and tube agglutination tests for the detection of Brucella canis antibodies in experimentally infected dogs. The microslide gel-diffusion and macro-tube agglutination techniques to detect Brucella canis antibodies in dogs were compared. Sera from dogs experimentally infected with B. canis and a random sample of dog sera with unknown histories of exposure to this organism were examined. The results of the gel-diffusion method employing specific rough Brucella saline-extract antigens of B. canis and Brucella ovis were comparable to those obtained by the tube agglutination test. The easily prepared, stable R antigen in the freeze-dried form offers a convenient, simple, and reliable diagnostic method for the serological detection of canine brucellosis by the gel-diffusion test.


Development of a defined minimal medium for the growth of Neisseria gonorrhoeae. This investigation describes the development of a solid and a liquid medium (Gonococcal Genetic Medium; GGM) which support the rapid growth of 41 gonococcal clinical isolates and laboratory strains with a minimum number of nutritional components. The complete medium contains minimal salts, eight amino acids, two nitrogen bases, vitamins, coenzymes, key metabolic intermediates, and some miscellaneous components. Results indicate that GGM can be modified and simplified even further than we described. In liquid GGM, several gonococcal strains grew logarithmically after a 2- to 3-h lag period with generation times ranging from 72 to 115 min, reaching optical densities of 175 to 320 Klett units in the presence of seven amino acids and in the absence of a CO(2) atmosphere. The development of a solid and a liquid defined minimal medium such as GGM should greatly broaden the avenues of experimentation for biochemical genetic studies with N. gonorrhoeae, especially gonococcal genetic transformation. N. gonorrhoeae can be classified into eight major and minor phenotypic groups, depending on its growth responses on GGM to just five amino acids: cysteine and cystine, arginine, proline, isoleucine, and serine. Such results demonstrate the feasibility of using GGM as a simple, sensitive, rapid probe for investigating the epidemiological patterns of gonorrhea.


Simple, inexpensive procedure for the disruption of bacteria. Small volumes (1 to 2 ml) of bacterial cultures, with turbidities ranging from 3 to 10, were disrupted 50 to 90% (measured as a decrease in turbidity) within 2 min, by shaking them on a Vortex-type mixer in the presence of glass beads. This method of disrupton was effective for cells in the following genera: Streptococcus, Lactobacillus, Staphylococcus, Bacillus, and Escherichia. After low-speed centrifugation, the resulting extract can be used as potential sources for enzymes, transforming deoxyribonucleic acids, cell walls, membranes, etc.


Use of sodium polyanethol sulfonate in the preparation of 5 per cent sheep blood agar plates. An alternative method to defibrinating sheep blood for use in bacteriological media is described. The new procedure incorporates sodium polyanethol sulfonate in a concentration of 0.05% (vol/vol). In testing 117 bacterial and fungal isolates, no significant differences were found with respect to adequate growth, pigment production, hemolytic reactions, and other physical attributes. Further tests demonstrate that the sodium polyanethol sulfonate in sheep blood agar plates does not cause any aberrations in zone sizes around disks used in antibiotic susceptibility tests. Consequently, the method represents a suitable alternative to the use of defibrinated sheep blood in the preparation of bacteriological media.


Characterization of the precipitin bands detected in the immunodiffusion test for paracoccidioidomycosis. In order to characterize the precipitin bands detected in the immunodiffusion test for paracoccidioidomycosis, a study was undertaken in 54 patients with the disease. On the basis of the pattern of known control sera, the three commonly observed lines of precipitate were designated as 1, 2, and 3 according to their location in the immunodiffusion plate. At time of diagnosis, 28 of the patients exhibited all three bands, 16 gave two bands, and 10 showed only one precipitin line. Over 50 of the sera with three bands had high complement fixation titers (above 1:512), whereas those with one band exhibited lower titers. A similar picture was obtained with the quantitative agar-gel techniques, where titers of 1:64 and above were more commonly observed in sera with three precipitin lines. Follow-up studies carried out in 18 patients revealed that band 3 disappeared first, followed by band 2, and, finally, by band 1. At the end of 2 to 3 years, 85.7% of the patients had lost band 3, 75% band 2, and only 27.7% band 1. Cross-reactions with histoplasmin were found in eight patients who gave the M precipitin line with this antigen. It was found that the latter band and our paracoccidioidin band 3 fused, producing lines of identity. Bands 1 and 2 were specific. The implications of these findings are discussed.


Antibiotics excreted into the bile--action on the tone and motility of the bile duct.


Purification and some properties of streptolysin O.


Intravenous hyperalimentation for the onco-surgical patient.


Rapid assay of proteolytic enzymes on film material.


The diagnostic significance of anginal symptoms.


Dilution curves studies in coumarin plasma and in artificially depleted abnormal control plasmas.


Some observations on the fine structure of the epidermal-dermal junction in the skin of the frog tadpole, Rana rugosa.


Tuberculosis in mink.

Tuberculosis in mink.


The organization of the second visual area (V II) in the owl monkey: a second order transformation of the visual hemifield.


Iron absorption after splenectomy in hereditary spherocytosis.


Dynamic patterns of brain cell assemblies. IV. Mixed systems. Influence of exogenous low-level currents. Are weak oscillating fields detected by the brain?


Survival of Listeria monocytogenes in soil and water.


A survey for sarcosporidial cysts in east African game animals.


A note on the blood parasites of some birds from the Republic of Madagascar.


Parasites of the tide pool fish Liparis atlanticus (Osteichthyes:Liparidae).


Indications of a viral etiology for marble spleen disease in pheasants.


Isolation of viruses from wild mammals in West Africa, 1966-1970.


Acidic fraction of ribosomal proteins from Lactobacillus acidophilus.


The distribution and character of glomerular deposits in systemic lupus erythematosus.


The negatively charged protein extracted from Tetrahymena pyriformis as an attractant in Amoeba proteus chemotaxis.


Localization of intracellular antigens by immunoelectron microscopy.


Further studies on the factor in lung-conditioned medium stimulating granulocyte and monocyte colony formation in vitro.


Method for the analysis of tRNA patterns in Drosophila melanogaster using an amino acid analyser.


Somple flow-cell for the fluorimetric study of conformational changes of proteins on agarose matrix.


A scanning dual wavelength spectrophotometer: application to the study of photosynthetic electron transport.


Radioimmunoassays of 3,4,5-trimethoxyphenethylamine (mescaline) and 2,5-dimethoxy-4-methylphenyl-isopropylamine(DOM).


Effect of brinolase on lens extraction in cynomolgus monkeys (Macaca fascicularis). A double blind study.


Analysis of polypeptide molecular weights by electrophoresis in urea.


Brinolase for lens extractopm in cynomolgus monkey (Macaca fascicularis). A toxicity study.


Schwann cells and perineurium in neuroma. Some morphological aspects.


Reversed-phase liquid chromatography of some pesticides and related compounds. Solubility-retention relationships.


Distribution of goldthioglucose in mice with and without experimental allergic encephalomyelitis.


Ultrastructural reorganization, DNA synthesis and mitotic division of myocytes in atria of rats with left ventricle infarction. An electron microscopic and autoradiographic study.


Trisomy for short arm of chromosome 20.

Trisomy for short arm of chromosome 20.


The pharyngeal hypophysis in some laboratory animals.


The natural history of endogenous skin malignancy as a basis for experimental research.


WHO Expert Committee on Malaria: sixteenth report.


Polyribosomes associated with the Golgi apparatus.


Typing of Pseudomonas aeruginosa.

Typing of Pseudomonas aeruginosa.


The influence of juvenile hormone on the plasma membrane of symbiotic bacteria.


Frustration and self-aggression in social isolate rhesus monkeys.


Studies in partially-treated and chronic gonococcal urethritis.


Protein-calorie malnutrition in West African children.


Magnesium deficiency.

Magnesium deficiency.


Clinico-electroencephalographic study of epilepsy after head injury.


Latex agglutination test for invasive amoebiasis.


Wernicke's encephalopathy in a child with congenital cardiomegaly. 2. Morphological aspects and pathogenetic considerations.


The nutrition problem in India.

The nutrition problem in India.


Asthma preventive developed.

Asthma preventive developed.


Population genetic studies in Nigeria.

Population genetic studies in Nigeria.


Nycthemeral variation in the parasitaemia of Trypanosoma minasense in naturally infected marmosets of the genus Callithrix (primates, Callithricidae).


Rhesus non-isoimmunization. A review and case report.


Juvenile hormone and the adult development of Drosophila.


The effects of heavy metal ions on the motility of sea urchin spermatozoa.


A comparison of the absorption of effervescent preparations of paracetamol and penicillin V (phenoxymethylpenicillin) with solid dose forms of these drugs.


DMSO: a new respiratory stimulant?

DMSO: a new respiratory stimulant?


Radiation enteritis.

Radiation enteritis.


Intravenous hyperalimentation protocol.

Intravenous hyperalimentation protocol.


Unproven methods of cancer management. Grape diet.


Use of cromolyn sodium in childhood asthma.


The role of genetics in human cancer.

The role of genetics in human cancer.


Lymphomas--troublesome problems in management.


Alexander Hughes Bennett (1848-1901) and Rickman John Godlee (1849-1925).


Early diagnosis of colorectal cancer.

Early diagnosis of colorectal cancer.


Precancerous lesions of the uterine cervix in pregnancy.


Malignant scrotal masses in children.

Malignant scrotal masses in children.


Endoscopic examination of the colon and rectum.


Editorial: Cancer nursing--something old, something new.


Cell interaction in conjugation of ciliates.


Beta, gamma unsaturated amino acids as irreversible enzyme inhibitors.


Metastatic cervical nodes of unknown primary origin.


A case of cerebral tumor--the surgical treatment.


Chelating agents for the binding of metal ions to macromolecules.


Lymphocyte transformation in human Plasmodium falciparum malaria.


Recovery from anti-IG induced immunosuppression: implications for a model of Ig-secreting cell development.


Human cancer virus vaccines.

Human cancer virus vaccines.


Evarts A. Graham (1883-1957).

Evarts A. Graham (1883-1957).


The role of activated macrophages in specific and nonspecific cytostasis of tumor cells.


A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement.


TRIC type K, a new immunologic type of Chlamydia trachomatis.


Diagnosis and management of common skin cancers.


Successful removal of an entire lung for carcinoma of the bronchus.


Distribution of isotypic and allotypic human IgG antigens in non-human primates.


Immunoglobulin expression of cells from human lymphoblastoid lines. I. Heavy and light chain antigens of the cell surface.


Editorial: A patient's right to die--the easy way out?


Immunoglobulin expression of cells from human lymphoblastoid lines. II. Interrelationship among surface, cellular, and secreted immunoglobulins.


Human lymphocyte membrane immunoglobulin as a reflection of maturation.


The capping of surface immunoglobulin on mouse myeloma cells.


Specific assay of gentamicin in the presence of penicillins and cephalosporins. Use of commercially manufactured beta-lactamases.


Studies of the formation of a violet-reddish pigment from the cephalosporin derivative celospor (C 36,278-Ba).


Clinical and laboratory investigations on ticarcillin, an anti-pseudomonal antibiotic.


Preliminary clinical experience with ticarcillin (BRL 2288) in 101 patients treated for severe respiratory infections.


Interaction aspects of antimycobacterial drugs in the chemotherapy of tuberculosis. II. The role of rifampicin and other drugs in the dependent or independent action of drug associations in vitro.


Alterations in the sensitivity pattern after use of trimethoprim-sulfamethoxazole for two years in the treatment of urinary tract infections.


Serologic group relationship of P and U streptococci.


The distribution of blood group frequencies in mainland Tanzania Africans.


Amniotic fluid bilirubin quantitation in the management of the Rh sensitized female.


Microdetermination of alpha-amino-acids through chelation with copper and titration with EDTA.


Serologic detection of breast cancer.

Serologic detection of breast cancer.


Gonococcal infections. Laboratory, clinical and epidemiological aspects.


Studies on the live attenuated rubella virus vaccine.


The Mm. subcostales in man and monkeys.

The Mm. subcostales in man and monkeys.


Pseudomonas resistance due to inactivated susceptibility disks. The deterioration of carbenicillin is similar to that of other penicillins. Susceptibility test results, by using disks which have been exposed to humidity, may indicate false resistance. Proper storage and handling methods are suggested.


Haematological and plasma biochemical parameters in adult male sheep.


On the morphology of testicular and ampullar spermatozoa in Egyptian buffalo-bulls.


Investigations on urinary oestrogen excretion from ewes with special reference to the clinical condition of the genital tract. 3. Non-breeding season.


Effect of gestyl on the urinary excretion of oestrogen in ewes during the non-breeding season.


Myopathy in an irish terrier with a metabolic defect of the isolated mitochondria.


Effect of isonicotinic acid hydrazide and polyvinylpyrrolidone on experimental peritoneal adhesions in the rabbit.


Critical issues in infancy and early child development.


Distribution and life cycle stages of lung mites (Pneumonyssus spp.).


Solid tissue masses formed in vitro from cells cultured on artificial capillaries.


Letter: Gonorrhea in obstetrics and gynaecology.


Transabdominal isthmic amniocentesis in RH-immunization with particular reference to complications.


Plasma levels of nonconjugated oestradiol-17beta and oestriol in high risk pregnancies.


Dependence of radiation induced aneuploidy from chromosomal length in Drosophila melanogaster. II. X chromosomes and X-4 duplication chromosomes.


Irradiation-induced crossing-over in Drosophila males. Cytological investigation of crossovers.


Study of the operon of riboflavin biosynthesis in Bacillus subtilis. IV. Regulation of the synthesis of riboflavin synthetase. Investigation of riboflavin transport through the cell membrane.


Functional recovery after lesions of the nervous system. II. Recovery of function after lesions of the central nervous system: history and prospects.


Functional recovery after lesions of the nervous system. 3. Developmental processes in neural plasticity. Sparing of language functions after early unilateral brain damage.


Functional recovery after lesions of the nervous system. IV. Structural correlates of recovery in adult subjects. Equipotentiality and sensorimotor function.


Functional recovery after lesions of the nervous system. IV. Structural correlates of recovery in adult subjects. Redundancy as a possible mechanism for escape or recovery from somatic sensory deficits.


Functional recovery after lesions of the nervous system. V. Neural plasticity and behavioral recovery in the central nervous system. Recovery of function after sequential ablation of the frontal lobes of monkeys.


Mutants of Bacillus subtilis with altered capacity to be donors of DNA in spontaneous transformation. I. Method of isolating mutants.


Remote cytogenetic effect of acute irradiation in monkeys. I. Prolonged persistence of chromosome damage in marrow cells.


Experimental digital replantation after prolonged cooling.


Immunological properties of membrane fractions from wild type and dnaA mutants of Escherichia coli.


Anaemia in early infancy.

Anaemia in early infancy.


DNA polymerase activities in Vero cells infected with herpesvirus Saimiri.


Properties of 5'-nucleotidase from Bacillus cereus obtained by washing intact cells with water.


Excessive hospitalization can be cut back.


Studies on liver mitochondrial 5'-endonuclease activity in rats fed carcinogenic amines and on their binding to mitochondrial proteins.


The differential radiologic diagnosis of bone tumors.


Histochemical observations on the development of interstitial gland tissue during the maturation of marmoset ovary.


Fate of auricular transplants and repair of auricular gaps in the grivet monkey (Cercopithecus aethiops aethiops).


Evaluation of amino acid mixtures for total parenteral nutrition.


Proceedings: Inhibitory effect of beta-aminopropionitrile on several amine oxidases.


Luminal events of lipid absorption in protein-calorie malnourished children; relationship with nutritional recovery and diarrhea. I. Capacity of the duodenal content to achieve micellar solubilization of lipids.


Luminal events of lipid absorption in protein-calorie malnourished children; relationship with nutritional recovery and diarrhea. II. Alterations in bile acid content of duodenal aspirates.


Vitamin B6 metabolism in women using oral contraceptives.


Basal energy metabolism in protein-calorie malnutrition and vitamin A deficiency.


Activity programs for long term care institutions.


Properdin factor D. II. Activation to D by properdin. The protein in the properdin pathway responsible for conversion of precursor factor D to D has been isolated and found to be identical with properdin. Sequential ion exchange and gel filtration chromatography demonstrated identity between properdin protein, measured by radial immunodiffusion, and the capacity to activate D to D, assessed by formation of the intermediate, EAC43B(D). Properdin, purified in this manner, was homogeneous on acid polyacrylamide disc gel electrophoretic analysis, with the band of protein corresponding to the position of eluates in the replicate gel capable of activating highly purified D. Demonstration of the homogeneity of purified D by alkaline disc gel electrophoresis, coupled with the linear stoichiometric hemolytic titrations of each factor, indicates that direct interaction between properdin and D generates D. Thus, activation of D by properdin represents a mechanism in the properdin pathway by which D becomes available for formation of the C3b-dependent C3 convertase.


Specific binding of nerve growth factor (NGF) by murine C 1300 neuroblastoma cells. Murine C 1300 neuroblastoma cells bind with high avidity on their membrane surface the nerve growth factor (NGF), a protein capable of inducing differentiation of sympathetic nerve cells. The total binding capacity of NGF by the cells was quantitatively measured by a radioimmunoassay technique, using (125)I-labeled NGF. An average number of about 10(6) molecules of NGF could be bound, at saturation, by each cell with an average relative association constant of about 10(7) liters/mol. Using synchronized cells, it was found, however, that either the number of molecules of ligand bound or the avidity of the binding interaction between NGF and cells varied depending upon their growth cycle, the maximal-binding occurring during the G(1) and early S phase. Binding of [(125)I]NGF was suppressed by trypsin treatment of the cells, however new receptor sites were rapidly replaced onto the membrane surface within 1-2 h. Cells exposed to 3 M KCl released into the supernate a protein product exhibiting similar high avidity for NGF. Acrylamide gel electrophoresis suggested a restricted molecular heterogeneity of this product, with a major component in the 52,000 mol wt region. Antibodies made specific to this protein were capable, in the absence of the complement, of inhibiting the binding of [(125)I]NGF by the cells and in the presence of the complement they killed them.


Schistosoma mansoni: immediate hypersensitivity to adult antigens in the rat.


Aspects of experimental hepatocarcinogenesis. IV. Changes in the liver following cessation of carcinogen administration.


Extended surgical adjuvant thiotepa for mammary carcinoma.


Are elemental diets useful in bowel preparation?


Identification of lymphocyte-dependent antibody in sera from multiply transfused patients.


Nephritogenic glycoprotein. 3. Immunochemical studies on nephritogenic activity of homologous water-soluble glycoproteins extracted from various rat organs.


Functional recovery after lesions of the nervous systems. 3. Developmental processes in neural plasticity. Recovery of function after CNS lesions in infant monkeys.


Carbon-13 nuclear magnetic resonance studies of structure and function in thyrotropin-releasing factor. Determination of the tautomeric form of histidine and relationship to biology activity.


Functional recovery after lesions of the nervous system. IV. Structural correlates of recovery in adult subjects. Recovery of motor function in rhesus monkeys.


Iron absorption from Southeast Asian diets.


Macroglobulinemia-myeloma double gammopathy. A study of four cases and a review of the literature.


The receptor proteins for concanavalin A and Lens culinaris phytohemagglutinin in the membrane of the human erythrocyte.


Regulation of aromatic amino acid biosynthesis in Bacillus subtilis 168. Purification, characterization, and subunit structure of the bifunctional enzyme 3-deoxy-D-arabinoheptulosonate 7-phosphate synthetase-chorismate mutase.


Formation and release of 3H-tryptamine from 3H-tryptophan in rat spinal cord slices.


The effect of ventromedial tegmental lesions on the disposition and biosynthesis of dopamine and serotonin.


Giant duodenal diverticula.

Giant duodenal diverticula.


Large diverticulum of the anal canal. Case report and review of the literature on anal canal and rectal diverticula.


Radiotherapy of tumors of the urinary tract. Hickey lecture, 1974.


Giant sigmoid diverticulum.

Giant sigmoid diverticulum.


Studies on the E strain of Rickettsia prowazeki. Cultivation of E strain of Rickettsia prowazeki in mouse lung resulted in a marked increase in virulence for guinea pigs following 12 passages (but not 6 passages) in both immunosuppressed and normal mice. Attempts at passaging E strain in normal guinea pigs were unsuccessful. Isolates of E strain in the chicken embryo yolk sac either from testes and peritoneal washings or from the brain of immunosuppressed guinea pigs did not show enhanced virulence for guinea pigs.


Immuno-epidemiology of malaria: a study in a tribal area of West Irian. An investigation of malariometric indices in relation to immunoglobulin levels, rheumatoid factors, and antithyroglobulins was carried out on 78 members of the Arfak tribe near Manokwari in Western New Guinea, in the course of a WHO assessment of malaria control activities in that region. The population investigated had been exposed to a period of epidemic malaria, as indicated by the small differences in malariometric indices between consecutive age groups. Typically high spleen sizes were recorded, as found generally among Papuans in similar situations. Falciparum malaria was most prevalent, almost equal to cases of vivax and malariae malaria together. IgM levels were very high, while those of IgG, IgA and IgD were not elevated. Total serum protein was rather low. No correlation between malariometric indices, autoantibodies, and immunoglobulin levels could be found. In particular there was no correlation between IgM levels and spleen indices, such as has been found in many other surveys. It is suggested that splenomegaly may show no correlation with the IgM level in Papuan populations without previous selection.


A serogroup A meningococcal polysaccharide vaccine: studies in the Sudan to combat cerebrospinal meningitis caused by Neisseria meningitidis group A. Vaccination against cerebrospinal meningitis (CSM) has regained interest with the use of capsular polysaccharides (or polyosides) of the meningococcus as specific immunizing agents. These compounds proved to be effective in the USA against meningitis caused by Neisseria meningitidis serotype C. This study considers whether the polysaccharides of the serotype A meningococcus, which is prevalent in the African CSM belt, could be protective in epidemic conditions. Taking advantage of the usual seasonal peak of CSM cases, controlled field trials were undertaken in the Sudan early in 1973. 21 640 persons were vaccinated, half of them with a meningococcal polyoside A vaccine and the other half with tetanus toxoid as a placebo. In the former group there were no cases of meningitis, whereas in the latter 10 cases were reported, of which 7 were confirmed by laboratory tests. These studies indicate that the meningococcal polyoside A vaccine is efficient in epidemic conditions and could be used to control outbreaks of meningococcal meningitis.


Comparison of indirect haemagglutination and immunofluorescence tests for malaria antibody in Aotus monkeys infected with Plasmodium falciparum. Application of indirect haemagglutination tests for malaria. Longitudinal observations were made on 6 Aotus monkeys repeatedly infected with Plasmodium falciparum (West African and Palo Alto strains). Immunofluorescence titres were higher than indirect haemagglutination titres in the primary phase of the infections. Both serological tests were consistently positive later in the infections. Precipitins were often not detectable even during episodes of parasitaemia.


Application of the indirect haemagglutination test for malaria: reproducibility with Plasmodium falciparum-sensitized cells. The reproducibility of the IHA test was assessed. Two batches of glutaraldehyde-fixed sheep cells were used and the cells were sensitized with different batches of P. falciparum antigen obtained from 4 owl monkeys. At the individual level the IHA test appears to have a reproducibility of approximately 90%.


Tooth root abscess and fistula in the squirrel monkey (Saimiri sciureus).


Sustained effects of nitroglycerin ointment in patients with angina pectoris.


Biotransformation of diethyl ether and chloroform.


Three pregnancy-associated human plasma proteins: purification, monospecific antisera and immunological indentification.


The recovery of indicator bacteria on selective media.


Studies on the mechanism of the sporicidal action of glutaraldehyde.


Characterization of pesticin. Separation of antibacterial activities.


Studies on the group-specific polysaccharide of Neisseria meningitidis serogroup X and an improved procedure for its isolation.


Biosynthesis of peptidoglycan in the one million molecular weight range by membrane preparations from Bacillus megaterium.


Synthesis of cross-linked peptidoglycan attached to previously formed cell wall by toluene-treated cells of Bacillus megaterium.


Purification and characterization of the thermophilic D-alanine carboxypeptidase from membranes of Bacillus stearothermophilus.


Principles of parenteral alimentation.

Principles of parenteral alimentation.


Characterization of the forssman glycolipid hapten of horse kidney by mass spectrometry.


Radiation therapy in Hodgkin's disease.

Radiation therapy in Hodgkin's disease.


Unitary responses in frog olfactory epithelium to sterically related molecules at low concentrations. Responses of receptor cells in the frog's olfactory epithelium were recorded using platinum-black metal-filled microelectrodes. Spontaneous activity varied over a wide range from 0.07 to 1.8 spikes/s. Mean interspike intervals ranged from 13.7 to 0.5 s. Excitatory responses to six sterically related compounds at low concentrations were investigated. Stimuli were delivered in an aqueous medium. Thresholds for impulse initiation varied from greater than 1 mM down to the nanomolar concentration range. Thresholds of different olfactory receptors to the same stimulus could vary by several log units. Thresholds of the same receptor cell to different stimuli could be within the same order of magnitude, or could vary by as much as 5 log units. Based upon quantitative measures of stimulus-evoked excitatory responses it appeared that some receptors did not discriminate among sterically related molecules, whereas other receptors clearly discriminated between stimuli which evoke similar odor sensations.


Utilization of thioridazine combined with hydergine in the treatment of incipient mental disturbances in cerebral atherosclerosis.


Vitellogenetic processes and cytochemical aspects in the growing oocytes of the bentonic teleost Mugil chelo CUV.


Ultrastructural cytochemical study of acid phosphatase in bovine ruminal epithelium.


Alkaline phosphatase activity in differentiating liver of chick. A histochemical and quantitative study.


Histochemical studies on the chorioid plexuses of the goat embryos. 3. Histochemical distribution of acid and alkaline phosphatases.


A histochemical study of some aspects of the metabolism of glutamic acid in the cerebellum of mammals.


Demonstration and interspecies cross-sensitization of reaginic antibodies in dogs infected with Dirofilaria immitis.


Scrub typhus in eastern Taiwan, 1970.

Scrub typhus in eastern Taiwan, 1970.


Exoerythrocytic stages of Plasmodium vivax in Ateles monkeys.


On the interaction of Ricinus communis lectin with plant amyloids.


Electroimmunodiffusion of IgG heavy chains in nanogram quantities with a carboxymethyl-cellulose-agarose gel.


A new topical steroid-antibiotic combination, diprogenta.


A multicentric trial of a new steroid, betamethasone benzoate, in common dermatological disorders.


Improvement of long-standing ventricular premature beats following prednisone therapy.


Long-term safety of Nefopam hydrochloride (Acupan), a new analgesic formulation.


A clinical evaluation of nefopam hydrochloride (Acupan): a new analgesic.


An evaluation of the effectiveness of simethicone in acute upper gastrointesinal distress.


A pilot study of ORF 8063, a new benzodiazepine in anxious alcoholic patients.


Glaziovine versus diazepam: a double-blind clinical trial.


Methylphenidate in children with minimal brain dysfunction: effects on attention span, visual-motor skills, and behavior.


Clinical and computerized EEG effects of U-31,920, a new anxiolytic.


Vitamin C prophylaxis and some problems of statistical inference.


Nicotinic acid plasma concentrations after ingestion of 1,3,4,6-tetranicotinoyl-fructo-furanose (tetranicotinoylfructose, nicofuranose).


Physiology of spores of mycobacillin producer and non-producer mutants of Bacillus sbutilis.


Respiration and metabolic processes of bacteria in autoclaved and gamma-irradiated soil.


An effect of centromere function on the behavior of ring-X chromosomes in Drosophila melanogaster. It is shown that under the influence of an autosomal meiotic mutant that causes abnormalities in meiotic centromere function (mei-S332), ring-X chromosomes are frequently nonrecoverable. Evidence is presented that this nonrecoverability is caused by a failure of sister ring-chromatids to successfully effect an equational separation with resultant dominant lethality. Because mei-S332 results in meiotic abnormalities only after replication has been completed, and because ring chromosomes are normally transmitted with approximately the same efficiency as rod chromosomes, it is suggested that during replication in normal meioses, sister ring-chromatids form mutually interlocked ring complexes that are resolved without genetic consequences at anaphase II, with the resolution owing at least in part to normal centromere function.


Microdifferentiation in a natural population of Drosophila melanogaster to alcohol in the environment. Strains of D. melanogaster derived from a vineyard population were more resistant to alcohol in the environment than strains from a population derived from an area removed from the vineyard. Within the vineyard population those strains most closely associated with alcohol in the environment in the cellar were more resistant than those collected outside the cellar. There was evidence of gene flow between the inside and outside cellar components of this population, but microdifferentiation had occurred within the cellar in spite of this. The adaptation appears to be independent of the ADH system and involves both additive and dominance genetic effects. D. simulans, a species not found in the cellar and susceptible to the presence of alcohol, showed no differentiation between vineyard and removed populations.


Glycol methacrylate embedding in enzyme histochemistry: application to arthropode tissue incubated for demonstration of unspecific esterase and succinic dehydrogenase activity.


Analysis for possible linkage between the loci for the Waardenburg syndrome and various blood groups and serological traits.


The effects of chemical modification by N-bromosuccinimide of saccharifying alpha-amylase from Bacillus subtilis on various substrates.


A study of diabetes in relation to blood groups and cholesterol levels.


Subacute sepsis of the hip treated by antibiotics and cemented prosthesis.


Sensitivity of Escherichia coli to viral nucleic acid. 8. Idiosyncrasy of Ca2+-dependent competence for DNA.


Precise evaluation of the reduction of severe ankle fractures.


Physiopathology of the cerebellum in the monkey. I. Origin of cerebellar afferent nervous fibers from the spinal cord and brain stem.


Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport. A soluble fatty acid-binding protein (FABP), mol wt approximately 12,000 is present in intestinal mucosa and other tissues that utilize fatty acids, including liver, myocardium, adipose, and kidney. This protein binds long chain fatty acids both in vivo and in vitro.FABP was isolated from rat intestine by gel filtration and isoelectric focusing. It showed a reaction of complete immunochemical identity with proteins in the 12,000 mol wt fatty acid-binding fractions of liver, myocardium, and adipose tissue supernates. (The presence of immunochemically nonidentical 12,000 mol wt FABP in these tissues is not excluded.) By quantitative radial immunodiffusion, supernatant FABP concentration in mucosa from proximal and middle thirds of jejuno-ileum significantly exceeded that in distal third, duodenum, and liver, expressed as micrograms per milligram soluble protein, micrograms per gram DNA, and micrograms per gram tissue. FABP concentration in villi was approximately three times greater than in crypts. Small quantities of FABP were present in washed nuclei-cell membrane, mitochondrial and microsomal fractions. However, the amount of FABP solubilized per milligram membrane protein was similar for all particulate fractions, and total membrane-associated FABP was only about 16% of supernatant FABP. Intestinal FABP concentration was significantly greater in animals maintained on high fat diets than on low fat; saturated and unsaturated fat diets did not differ greatly in this regard.The preponderance of FABP in villi from proximal and middle intestine, its ability to bind fatty acids in vivo as well as in vitro, and its response to changes in dietary fat intake support the concept that this protein participates in cellular fatty acid transport during fat absorption. Identical or closely related 12,000 mol wt proteins may serve similar functions in other tissues.


Effects of hemorrhage on regional blood flow distribution in dogs and primates. The effects of hemorrhage on arterial pressure, blood flows, and resistances in the coronary, mesenteric, renal, and iliac beds of healthy, conscious dogs and intact, tranquilized baboons were studied. Mild nonhypotensive hemorrhage (14+/-2 ml/kg) increased heart rate and mesenteric and iliac resistances slightly but significantly, and decreased renal resistance (-13+/-2%). Moderate hypotensive hemorrhage, 26+/-2 ml/kg, reduced mean arterial pressure (-23+/-2 mm Hg) and blood flows to the mesenteric (-56+/-3%), iliac (-58+/-5%), and coronary (-39+/-4%) vascular beds, and increased heart rate (+89+/-9 beats/min) and resistances in the mesenteric (+73+/-15%), iliac (+102+/-19%), and coronary (+27+/-5%) beds. In contrast to the other beds, renal flow rose 11+/-6% above control and renal resistance fell 31+/-2% below control. Renal vasodilatation with hemorrhage was also observed in five baboons. The increases in mesenteric and iliac resistances were blocked almost completely by phentolamine, while the increase in coronary resistance was only partially blocked by phentolamine. The renal dilatation was not blocked by phentolamine, propranolol, atropine, or tripelennamine, but was prevented by indomethacin, suggesting that this dilatation was mediated by a prostaglandin-like compound. Thus the peripheral vascular responses to hemorrhage involve intense vasoconstriction in the mesenteric and iliac beds. In the normal conscious dog and the intact, tranquilized primate, the renal bed does not share in the augmentation of total peripheral resistance with nonhypotensive and moderate hypotensive hemorrhage, but does with more severe hemorrhage. In fact, renal vasodilatation occurs with nonhypotensive or moderate hypotensive hemorrhage, which can be prevented by blockade of prostaglandin synthetase with indomethacin.


Physiopathology of the cerebellum in the monkey. 2. Motor disturbances associated with partial and complete destruction of cerebellar structures.


Effects of d-amphetamine, morphine and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation.


Mechanism of the vasoconstrictor action of prostaglandin B.


In vitro synthesis of adenovirus core proteins. mRNA extracted from polysomes of KB cells at late stages of productive infection with adenovirus type 2 was translated in a cell-free system derived from Krebs II ascites cells. Two of the polypeptides obtained in this reaction corresponded to the adenovirus core protein V and the precursor to core protein VII. The following criteria were used to establish identity between the in vitro products and the virion proteins: comigration during sodium dodecyl sulfatepolyacrylamide gel electrophoresis, cochromatography in sodium dodecyl sulfate-hydroxyapatite, specific immunoprecipitation of the precursor to core protein VII, and tryptic peptide analysis.


Isolation of Yersinia enterocolitica from monkeys and deers.


Transformation potentials of the noninfectious (defective) component in pools of adenoviruses type 12 and simian adenovirus 7. Pools of adenovirus 12 and simian adenovirus 7 were separated into four or five fractions by density gradient centrifugation in cesium chloride. Each fraction was analyzed for total in vitro infectivity units, total transformation activity, and for total virus particle (VP) content. Two major subpopulations were separated with mean densities of 1.30 +/- 0.02 and 1.34 +/- 0.02 g/ml, respectively. Virions in the 1.34 g/ml range were highly infectious (10(2) to 10(3) VP per infectivity unit) in contrast to virions at 1.30 g/ml density (10(4) to 10(5) VP per infectivity units). Transformation capacity was evenly distributed throughout fractions of both viruses, indicating that genetically incomplete or defective virus particles were not deficient in their ability to induce transformation. The average VP per transformation unit for adenovirus 12 (2.85 x 10(6)) and for simian adenovirus 7 (4.00 x 10(6)) did not vary significantly from fraction to fraction. These values were obtained with optimal input multiplicities of 16 to 64 VP per cell. At higher multiplicities the apparent increase in VP per transformation unit was attributable to the viral cytocidal effect on hamster cells. These studies revealed that quantitation of in vitro transformation based on VP multiplicities was more reliable than on the basis of infectious units. These estimates were independent of method of virus production, extraction, and purification.


Bacillus subtilis bacteriophage SP01, SP82, and phi e require host lysyl- and tryptophanyl-tRNA synthetases for phage development. Infection of Bacillus subtilis mutants having temperature-sensitive lysyl- or tryptophanyl-tRNA synthetases with bacteriophage SP01, SP82, or phie indicates that both host enzymes are essential for phage development. No apparent modification of the temperature-sensitive phenotype of the mutant host enzymes occurs during phage infection.


Antitubular basement-membrane antibodies in methicillin-associated interstitial nephritis.


Compensating victims of violent crime.

Compensating victims of violent crime.


The behavioral pharmacology of Sch 12679. A new psychoactive agent.


The fate of (14C)phenol in various species.


Metabolism of 3-acetamido-6-methyl-8-n-propyl-s-triazolo (4,3-a)pyrazine (I.C.I. 58,301) in animals.


The metabolism of sulphadimethoxypyrimidine.


Folate binding in animal plasma.

Folate binding in animal plasma.


Turnover of lysozyme-positive monocytes in normal rat blood.


Globin chain synthesis in sickle cell trait under conditions of folate antagonism.


Disodium cromoglycate in the treatment of allergic asthma.


First report of Hb E in Italy.

First report of Hb E in Italy.


A rapid screening test for detection of alpha-1 fetoprotein as an indicator of fetal distress.


Family with a high activity of serum diamine oxidase.


Ocular histopathology of Norrie's disease.


The eyes of embryos with chromosome abnormalities.


Experimental retinal detachment in the owl monkey. 11. The role of light in photoreceptor atrophy.


Corneal cryopreservation and the fate of corneal cells in penetrating keratoplasty.


Retinal degeneration in a baboon.

Retinal degeneration in a baboon.


An evaluation of tobramycin in experimental corneal ulcers.


Effect of nitrous oxide on air in vitreous.


Population ecology of Sulfolobus acidocaldarius. II. Immunoecolgical studies.


Incorporation of labelled amino acids by nuclei isolated from Euglena gracilis.


Inhibition of carotenoid synthesis in Myxococcus fulvus (Myxobacterales).


Mixed carbon source effect in the phenazine-alpha-carboxylic acid synthesis and the aromatic pathway in Pseudomonas spp.


Isolation, enumeration, and host range of marine Bdellovibrios.


Formation and regeneration of Penicillium chrysogenum protoplasts.


Endocytosis and the adaptive acid hydrolases in Tetrahymena pyriformis GL.


In vivo survival of cryopreserved endothelial cells in primates.


Intravitreal injection of dexamethasone. Treatment of experimentally induced endophthalmitis.


Effect of prostaglandin E1 administration on the heart glycogen synthase and phosphorylase systems.


Oxidative phosphorylation and respiration by liver mitochondria from polychlorinated biphenyl-intoxicated rats.


N-methylation of biogenic amines. I. Characterization and properties of an N-methyltransferase in rat brain using 5-methyltetrahydrofolic acid as the methyl donor.


Acid denaturation of bovine carbonic anhydrase B.


Structure of the mannan form Saccharomyces strain FH4C, a mutant constitutive for invertase biosynthesis. I. Significance of phosphate to the structure and refractoriness of the molecule.


Occurrence of trans-phytoene in microorganisms grown in the absence of carotenogenesis inhibitors.


Reserpine as an uncoupling agent.

Reserpine as an uncoupling agent.


Genes and isoenzymes controlling the first step in the aromatic amino acid biosynthesis in Schizosaccharomyces pombe.


Studies of substrate hydrolysis by an esterase isozyme of rat serum.


Bacterial citrate synthases: purification, molecular weight and kinetic mechanism.


The cells of origin of the corpus callosum in rat, cat and rhesus monkey.


The electron microscopical structure of thyroglobulin obtained by micropuncture of rat thyroid follicles.


Peptides with NH2-terminal tryptophan in the adenohypophysis. A chemical and fluorescence histochemical study.


Immunoglobulin classes in Xenopus laevis.


Deviation and laterality of hand preference in monkeys.


Identification of 4-chloro-4'-hydroxybiphenyl and 4,4'-dichloro-3-hydroxybiphenyl as metabolites of 4-chloro- and 4,4'-dichlorobiphenyl fed to rats.


In vitro antibacterial activity of 2-amino-4(2-ethynyl-1-methyl-5-nitroimidazole)-pyrimidine, a metronidazole derivative with antitrichomonad activity.


Gold thioglucose induced terminal degeneration in mouse hypothalamus.


Effect of hemorrhage on electrical and PH gradients in the intact stomach of the subhuman primate.


Opaque arthrography of the temporomandibular joint.


An assessment of the use of prophylactic antibiotics in third molar surgery.


Suicidal gunshot wounds resulting in severe maxillofacial injury.


A desmoplastic fibroma in the mandible.

A desmoplastic fibroma in the mandible.


Reovirus infected cells for studying microtubules and spindle poisons.


Epithelial cells in the periodontal membrane of teeth with and without periapical inflammation.


Antigenic relationship between pseudomonas Bal-31 membranes and bacteriophage PM2.


The kinetics of sodium transport in the toad urinary bladder. 3. The role of potassium.


Cerebrospinal fluid flow and iodide 131 transport in the spinal subarachnoid space.


Thyrotropin releasing hormine (TRH): distribution in the brain, blood and urine of the rat.


Endplate currents are shortened by octanol: possible role of membrane lipid.


Variation in ADH activity in class I and class II strains of Drosophila.


Aflatoxins in foods and feedstuffs. 2. Determination of the aflatoxin B1, B2, G1 And G2 contents in grain crops.


Quantitation of bovine liver catalase by single radial immunodiffusion.


Endontics in a capuchin monkey: reduction in the length of the canine crown.


High voltage electron microscopy on microgametogenesis of Haemoproteus columbae.


'Coupled transglucuronidation': a new tool for studying the latency of UDP-glucuronyl transferase.


A comparative study of human and monkey (Macaca irus) fibrinogen degradation products.


A comparative study of the nasal fossa of four nonhuman primates.


A comparison of anticoagulants for the analysis of glucose concentration and for haematological measurements in bovine blood.


A cytotoxicity assay of Pseudomonas aeruginosa culture filtrates by a dye-uptake test.


A fatal adenovirus infection of broiler chickens: inclusion body hepatitis.


A microcalorimetric study on the unfolding of E. coli ribosome.


A comparative serological study of Dermatophilus congolensis antigens prepared by different methods.


A plate-diffusion method for the detection of antistaphylolysin activity in human serum.


A new R factor from Pseudomonas aeruginosa.


A polyvalent Pseudomonas vaccine.

A polyvalent Pseudomonas vaccine.


A quick method for calculation of the vascular mean transit time.


A search for radioresistance in experimental populations of Drosophila with radiation histories.


A simple apparatus for the continuous monitoring of 14CO2 production from several small reaction mixtures.


A simple method for accurate assessment of the glomerular filtration rate in children.


A study of barrels and pyramidal dendritic clusters in the cerebral cortex.


A radioimmunoassay for measurement of 3,3',5'-triiodothyronine (reverse T3). A highly specific antiserum to 3,3',5'-triiodothyronine (reverse T(3), rT(3)) was prepared by immunization of rabbits with D,L-rT(3)-human serum albumin conjugate. Of the various thyroid hormone derivatives tested, only 3,3'-diiodothyronine (3,3'-T(2)) cross-reacted significantly (10%) with rT(3)-binding sites on the antiserum, while thyroxine (T(4)) and triiodothyronine (T(3)) cross-reacted by less than 0.1%. The antiserum was used in a simple, sensitive, precise, and reproducible radioimmunoassay (RIA) for measurement of rT(3) in ethanolic extracts of serum. The dose-response curves of inhibition of the binding of [(125)I]rT(3) to antibody obtained by serial dilutions of serum extracts were essentially parallel to the standard assay curve. Recovery of nonradioactive rT(3) added to serum before extraction averaged 93%. Serum rT(3) concentrations were found to be (mean+/-SD) 41+/-10 ng/100 ml in 27 normal subjects, 103+/-49 ng/100 ml in 22 hyperthyroid patients, 19+/-9 ng/100 ml in 12 hypothyroid patients, and 54+/-7 ng/100 ml in five subjects with elevated serum thyroxine-binding globulin: the values in each of the latter three groups of individuals were significantly different from normal. Reverse T(3) was detected regularly in normal or supranormal concentrations in serum of 12 hypothyroid patients rendered euthyroid or mildly hyperthyroid by treatment with synthetic T(4). It is suggested that serum rT(3) values noted here should be taken to reflect the relative changes in serum rT(3) rather than its absolute values in health and thyroid disease. True serum rT(3) may be somewhat different because: (a) D.L-rT(3) employed in the standard curve and L-rT(3) present in human serum may react differently with anti-D,L-rT(2). (b) Even though 3,3'-T(2), which cross-reacted 10% in rT(3) RIA, has been considered unlikely to be present in human serum, it may circulate in low levels. (c) Cross-reaction of T(4) in rT(3) RIA of 0.06% although small, could contribute to RIA estimates of rT(2); the effect of T(4) would be particularly important in case of serum of hyperthyroid patients. Thus, serum rT(3) concentration in hyperthyroid patients averaged 89+/-48 mug/100 ml after correction for cross-reaction effects of T(4): this value was about 14% lower than that before correction (see above). Serum rT(3) concentration in cord sera of seven newborns averaged 136+/-19 ng/100 ml; it was clearly elevated and within the range of values seen in hyperthyroid patients. This was the case when the mean T(4) concentration in the newborn cord sera was moderately higher than normal and about one-half that in hyperthyroid patients, whereas serum T(3) was markedly below the normal adult level. A Pronase hydrolysate of thyroglobulin prepared from pooled normal thyroid glands contained 0.042, 3.0, and 0.16 mug/mg protein of rT(3), T(4), and T(3), respectively. The various data suggest that: (a) rT(3) is a normal component of human serum and thyroglobulin: (b) peripheral metabolism of T(4) is an important source of the rT(3) present in serum: (c) peripheral conversion of T(4) to T(3) and rT(3) may not necessarily be a random process.


A study of Mycobacterium fortuitum (ranae).


A variant of factor 8 related antigen.

A variant of factor 8 related antigen.


A simple "variable blade" laryngoscope for use in animals.


A Clinicopathologic Conference from Veterans Administration Hospital Hines, Illinois: Nephritis-like symptoms progressing to congestive heart failure.


Accidental nosematosis in mice with impaired immunological competence.


Abnormalities of in vitro thyroid function tests in renal disease.


Acetylation of pronase trypsin.

Acetylation of pronase trypsin.


Acid denaturation of human carbonic anhydrase B. A fluorimetric kinetic study.


Acidic aqueous extraction of hypothalamic luteinizing hormone releasing hormone to study biological effects.


Acquired factor-IX inhibitor in a nonhaemophilic patient with autoimmune disease.


Action of flavonoids on blood cells: trimodal action of flavonoids elucidates their inconsistent physiologic effects.


Acute brucellosis with unexpected source.


Activities of neurons in area 3a of the cerebral cortex during voluntary movements in the monkey.


Affinity chromatography purification of rat alpha 1-foetoprotein.


Adjuvants and in vitro antibody production.


Affinity of UDP-glucuronyl-transferase for several substrates and for chloramphenicol.


Albumin and coagulation factor 8 (AHF).

Albumin and coagulation factor 8 (AHF).


Albumin and creatinine clearances in renal disease.


Alteration of vascular permeability in rabbits by culture filtrates of Bacillus cereus and related species. Crude culture filtrates of strains of Bacillus cereus, B. thuringiensis, and B. mycoides caused an increase in vascular permeability when injected intradermally into rabbits. The time course of the change in permeability was determined, and could easily be distinguished from a more transient effect induced by purified (from B. cereus) phospholipase C. The properties of the responsible factor were found to be similar to those reported for the guinea pig dermal factor and the ileal loop fluid inducing factor, namely: synthesis by vigorously aerated, logarithmically growing cells; inactivation by heating at 56 C; non-dialyzability; precipitation with ammonium sulfate; and antigenic characteristics. Permeability factor was not related to either the phospholipase C or the hemolysin produced by B. cereus. Activity of this B. cereus toxin, as measured in the vascular permeability and ileal loop assays, can easily be quantitated, but the greater simplicity, reliability, and economy of the vascular permeability test make it the method of choice for screening cultures or following toxin purification.


Altered metabolism in a Streptococcus lactis C2 mutant deficient in lactic dehydrogenase.


Action of metabolic inhibitors on competence and genetic transformation in Bacillus subtilis.


Aminoacyl transfer ribonucleic acid synthesis in toluene-treated liver cells.


Altered proteins with triosephosphate isomerase activity in suppressor-containing strains of Bacillus subtilis. Suppressor mutations in Bacillus subtilis cause the synthesis of a new protein with the enzymatic activity of l-leucine dehydrogenase and two groups of new proteins with the activity of triosephosphate isomerase. The new isoenzymes of triosephosphate isomerase are separable by zone electrophoresis and differ among themselves in elution behavior upon gel permeation chromatography. One group has an apparent average molecular weight of 120,000 to 135,000, which is more than twice that of the wild-type enzyme. Another group appears to be even higher in molecular weight. These data are consistent with the working hypothesis that the new isoenzymes are produced by extension of growing polypeptide chains through one or more chain-terminating triplets, although other mechanisms resulting in alteration of shapes, charges, or associations of the enzymes are not excluded.


Aminoglycoside antibiotics. V. The 4'-deoxybutirosins (Bu-1975C1 and C2), new aminoglycoside antibiotics of bacterial origin.