Circulatory immunoglobulin levels after an oral killed typhoid vaccination.


Histoplasmin sensitivity survey.

Histoplasmin sensitivity survey.


Degree of acetonaemia following epinephrine infusion to determine biochemical characterization of diabetes mellitus.


Factors influencing natural immunization in diphtheria in urban and rural communities in West Bengal.


Bacteriophage typing of hospital strains of Pseudomonas aeruginosa.


Evaluation of gel diffusion precipitin test for amoebiasis.


Listeria meningitis in Delhi (a pilot study).


Reduction of drug resistance of mycobacterium tuberculosis after treatment with hamycin.


Studies on freeze dried smallpox vaccine as a source of antigen in the precipitation-in-gel test.


Australia antigen in cirrhosis of childhood.


Bacterial response to combination of tetracycline and gentamicin.


Prevalence of Brucella agglutinins in sera received for serological test for syphilis and Widal test.


Diphtheria carriers among school chidren in Poona.


Letter: Raised intra cranial tension due to rapid brain growth.


Screening for PKU of preschool children and newborn infants in Hyderabad.


Blood free alpha amino nitrogen in hypoproteinemia.


Metabolic problems during mechanical ventilation of newborn infants.


Increased response of anoxic Bacillus megaterium spores to radiation at high dose-rates.


Diagnosis of rubella virus infection. II. The usefulness of sucrose density gradient centrifugation and indirect fluorescent antibody staining to demonstrate  rubella IgG antibodies.


Synthesis of bacteriophage phi DNA in toluenized preparations of Bacillus subtilis infected cells.


Australia antigen in viral hepatitis and hepatic cirrhosis.


An angiomatous malformation of brain with unusual clinical manifestations.


Folates in human serum.

Folates in human serum. Constituent serum folates have been shown to be altered and in some cases raised in diseases in which total folate levels are known to be frequently decreased. Absorption experiments showed that orally administered folate analogues affect the folate pool in different ways. The stability of the 10-formyltetrahydrofolate level in normal subjects is demonstrated.


Culture of specimens other than sputum for Mycobacteria. A comparison has been made of Lowenstein-Jensen medium, with or without added pyruvate, 7H11 oleic acid-albumin agar slopes made selective by the addition of antibiotics, and selective Kirchner medium in the isolation of tubercle bacilli from specimens other than sputum. A combination of a standard mild preliminary treatment with sulphuric acid and selective medium reduced the contamination rate to 0.1%. Neither acid treatment nor antibiotics appeared to reduce the isolation rate. An effective procedure is to treat all specimens (except cerebrospinal fluid) with acid and culture on two Lowenstein-Jensen slopes (one with pyruvate), a 7H11 selective slope, and in two bottles of selective Kirchner medium.


Proceedings: Recent researches on sphingolipidoses.


Renovascular hypertension in neurofibromatosis.


Comparison of the titres of ASO, anti-DNase B, and antibodies against the group polysaccharide of group A streptococci in children with streptococcal infections. Antibodies against the group polysaccharide of group A streptococci were estimated by means of a haemagglutination reaction. In this reaction human erythrocytes of blood group O were sensitized with polysaccharide esterified with myristoylchloride. The optimal conditions of the reactions were determined by varying the ester group content in the antigen and the amount of ester used for sensitization. The specificity of the reaction could be established by reacting sensitized erythrocytes with homologous and heterologous sera and by absorption experiments. Antistreptococcal group A polysaccharide titres (ASPAT) and antibody levels to streptolysine O and DNase-B were compared in a group of 52 children with proved streptococcal infection and in 52 age- and season-matched controls. Antibody levels were significantly higher in the patient group than in the controls. In the ASPAT there was clearly less overlap between patients and controls than in both other reactions. In the patient group the ASO titres were raised above normal in 27 cases (51.9%), anti-DNase-B titres in 18 (34.6%), and ASPAT in 40 (76.9%). Taken together the three reactions gave a positive score in 51 cases (98.1%) in the patient group against 17 cases (32.7%) in the controls. A positive antibody response is usually defined as a rise of two dilution increments between the acute and convalescent sera. According to this definition the ASPAT showed a response in 42%, ASO and/or DNase-B in 42%, and the three reactions taken together in 68% of paired sera from patients. It is believed the ASPAT will prove a welcome addition to the diagnostic outfit when the presence of streptococcal infection in children is considered.


Sterilization of the biological safety cabinet. Test strips comprising B subtilis spores or M phlei cells dried on aluminium foil (some serum-coated) were used to test sterilizing processes currently advised for safety cabinets. Exposure to formalin from a bowl, boiling excess formalin with the fan running, and ultraviolet radiation were all found to be unreliable, as was glutaraldehyde. Vaporization of 2 ml of formalin per 0.028 m(3) followed by exposure for 18 hours at ambient temperatures was 100% successful, and the depolymerization of paraformaldehyde tablets with a hair drier was a simple, very effective alternative method.


Immunological identity between seminal plasma ribonuclease (BS-1) and seminal vesicle ribonuclease (SV-1).


Proceedings: The freeze-etching approach to the study of islet pathophysiology in diabetes.


Mycoplasmacidal activity of bovine milk for T-mycoplasmas. Normal bovine milk and whey was mycoplasmacidal for 6 of the 13 strains of bovine T-mycoplasmas examined. The in vitro assay used also demonstrated no killing of the human, canine and simian T-mycoplasma strains after 4 hr. incubation. However, there appeared to be some cow-to-cow variation in possession of this activity, and following E. coli endotoxin stimulation of the mammary gland the activity was considerably reduced.Whey from three normal cows was fractionated on a Bio-Gel A 1.5 m. column and the mycoplasmacidal activity of the resulting five peaks assayed. Only the second peak, peak B, contained activity and was characterized as the only peak containing bovine IgA. The active component in whey, however, was found to be heat stable at 60 degrees C. for 60 minutes and to pass through a dialysis membrane. This is inconsistent with it being immunoglobulin.


A simplified method for the detection of rubella-specific IgM employing sucrose density fractionation and 2-mercaptoethanol. A simplified method for the detection of rubella-specific IgM in sera was developed involving HAI tests on only one fraction from a sucrose density gradient with and without treatment with 2-mercaptoethanol (2 ME). Slight trailing of IgG into the IgM fraction was shown to occur in patients with high titres of both IgG and IgM, but this could be detected by the 2ME treatment and did not affect the results.By this test, rubella-specific IgM was found in all of 54 patients with a rash and a rise of rubella HAI antibodies. When the antigen and serum were incubated for 1 hr. before adding the RBC, specific IgM was found in all 51 sera taken between 5 and 40 days after onset, and in about half the sera taken between 42 and 77 days, but in none of 16 people known to have possessed rubella antibodies at least a year previously. When antigen and serum were incubated for 18 hr. before adding the RBC, specific IgM was found in all of 21 sera taken between 2 and 49 days after onset, and in 6 of 11 sera taken between 50 and 117 days, but not in 9 people known to have possessed rubella antibodies at least a year before. The method has been found to be very useful in detecting recent rubella among patients in early pregnancy.


Clinical evaluation of practolol in the treatment of angina pectoris.


The survival and growth of Bacillus cereus in boiled and fried rice in relation to outbreaks of food poisoning. A number of outbreaks of food poisoning attributed to Bacillus cereus have been reported recently and all have been associated with cooked rice usually from Chinese restaurants and ;take-away' shops.Tests were made to assess the heat resistance of B. cereus spores in aqueous suspension, the growth of the organism in boiled rice stored at temperatures in the range 4-55 degrees C., and the effect of cooking and storage on the growth of the organism in boiled and fried rice. The spores of B. cereus survived cooking and were capable of germination and outgrowth. The optimum temperature for growth in boiled rice was between 30 degrees and 37 degrees C. and growth also occurred during storage at 15 degrees and 43 degrees C.To prevent further outbreaks it is suggested that rice should be boiled in smaller quantities on several occasions during the day, thereby reducing the storage time before frying. After boiling the rice should either be kept hot (> 63 degrees C.) or cooled quickly and transferred to a refrigerator within 2 hr. of cooking. Boiled or fried rice must not be stored under warm conditions especially in the range 15-50 degrees C.


Biology and pathogenicity of the microsporidian Perezia hyperae sp. n., a pathogen of the alfalfa weevil, Hypera postica.


Shell mats associated with microsporida in Biomphalaria glabrata: genetic studies.


Treatment of gonorrhea with cefazolin plus probenecid.


The antibacterial efficiencies of ovine IgA, IgM, and IgG.


Guidelines for total parenteral nutrition.


Letter: ATP content in erythrocytes of Plasmodium knowlesi-infected monkeys.


Proceedings: Inhibition of hypothalamic unit activity by iontophoretically applied luteinizing hormone releasing factor and thyrotrophin releasing factor.


Calcitonin given intragastrally and resistance to histamine-induced peptic ulcer in guinea-pigs.


Proceedings: The relationship between prolactin and gonadotrophins: effects of clomiphene administration in normal men.


Proceedings: Effect on prolactin secretion of thyrotrophin releasing factor.


Vaccinia virus polypeptide synthesis: sequential appearance and stability of pre- and post-replicative polypeptides.


A study of biogenic amine metabolites in the cerebrospinal fluid and urine of monkeys with chlorpromazine-induced dyskinesia.


Heterogeneity of the glial fibrillary acidic protein in gliosed human brains.


Treatment of congenital chylothorax.

Treatment of congenital chylothorax.


Solitary neonatal hepatic abscess.

Solitary neonatal hepatic abscess. A solitary hepatic abscess was found at postmortem examination in a neonate who died at 25 days of age. Elevation of the right diaphragm was noted radiologically from the first day of life, suggesting congenital presence of the abscess. Recognition of the previously unsuspected association between hepatic abscess and congenital diaphragmatic elevation might have led to surgical intervention and have increased the infant's chance of survival.


Detection of endotoxemia with the Limulus test: preliminary studies in severely malnourished children. Eighteen Peruvian children with protein-calorie malnutrition were studied to evaluate the usefulness of the limulus assay for endotoxin in detecting gram-negative sepsis. Nine of the children had at least one positive Limulus assay, and eight of this group had bacteriologic cultures indicative of gram-negative infection. Four of these nine children with positive Limulus assays died, whereas only one of the nine children with negative assays died. This preliminary study suggests the usefulness of the Limulus assay as an adjunct to bacteriologic cultures in the early detection of significant gram-negative infection in severely malnourished children.


Intracellular sodium and potassium concentrations in toad and frog oocytes during development. 1. During growth of oocytes of Bufo bufo from approximately 700-2000 mum in diameter, intracellular Na rose from 20 to 120 m-mole/l. cell water while K fell from 120 to 15 m-mole/l. cell water.2. In Rana temporaria Na similarly rose from 9 to 190 m-mole/l. cell water and K fell from 126 to 28 m-mole/l. cell water.3. At the same time in both Bufo and Rana the ouabain-sensitive Na efflux, the ouabain-insensitive Na efflux, and the total Na influx all increased.4. It is concluded that the predominant process is an increase of passive Na permeability. The increase of apparently active Na efflux may be secondary to the consequent rise in intracellular Na.


Intracellular sodium and potassium concentrations in oocytes of Bufo bufo at the beginning of maturation. 1. During the first phase of maturation in oocytes of Bufo bufo, after the growth phase but before ovulation, intracellular Na rises to 120 m-mole/l. cell water while K falls to 15 m-mole/l. cell water.2. At the same time, the ouabain-insensitive Na efflux and total Na influx both increase while the ouabain-sensitive Na efflux is unchanged.


Proceedings: The response of neurones in the pre-central cortex to an unexpected disturbance of finger position.


The St. Kitts vervet (Cercopithecus aethiops).


Normal T cell population in chronic lymphocytic leukemia: analysis of phytohemagglutinin dose-response curves.


BCG immunization in marmosets.

BCG immunization in marmosets.


Recurrent radial nerve palsy.

Recurrent radial nerve palsy.


Interrelationship of H+ excretion and Na+ reabsorption in the toad urinary bladder.


Pathways for movement of ions and water across toad urinary bladder. II. Site and mode of action of vasopressin.


Effect of fixatives on fracture plane in red blood cells.


Structure of a dimeric fragment related to the lambda-type Bence-Jones protein: a preliminary study.


Protein-protein proximity in the association of ribosomal subunits of Escherichia coli: crosslinking of 30 S protein S16 to 50 S proteins by glutaraldehyde or formaldehyde.


Strjcture of human plasma prealbumin at 2-5 A resolution. A preliminary report on the polypeptide chain conformation, quaternary structure and thyroxine binding.


Isolation of messenger RNA for an immunoglobulin kappa chain and enumeration of the genes for the constatn region of kappa chain in the mouse.


Membrane-bound polyribosomes in HeLa cells: association of polyadenylic acid with membranes.


New Japanese variant of human erythrocyte carbonic anhydrase.


Serologic relationship of coxsackie A-16 viruses from the epidemic of hand-foot-and mouth disease in Japan, 1970, to the prototype strain.


[Bedside nursing: Nursing of a patient with Buerger's disease associated with persistent pain].


Long-term therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymetholone in severely affected males and females.


Absence of antinatriferic and natriuretic activity in plasma ultrafiltrates (mol wt less than 50,000) and dialysates from volume-expanded dogs.


Convenient micro system for double diffusion immuno precipitin tests.


Current practice with vitamin K antagonist therapy.


The use of anti-human haemoglobin in forensic serology.


The action of pure phospholipases on native and ghost red cell membranes.


Isolation of spectrin from erythrocyte membranes.


Phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC 3.1.4.3) from Bacillus cereus.


Cell adhesion.

Cell adhesion.


Activity of some lysosomal enzymes in Hurler's syndrome (type i mucopolysaccharidosis).


Cell layer assay.

Cell layer assay.


Cations, antibiotics, and membranes.

Cations, antibiotics, and membranes.


The photometric titration of Fe(III) with EDTA using Tiron indicator.


The use of substituted hydrazones as metallochromic indicators: the EDTA titration of copper.


A comparison by gel diffusion of the Lancefield and Rantz extraction techniques used in grouping haemolytic streptococci.


An assessment of an automated immunoprecipitin technique for the measurement of immunoglobulins G, A and M.


Physico-chemical characterisation of rinderpest virus.


Defective interfering particles produced during the replication of measles virus.


SSPE measles virus: non-productive and productive infection in Vero cells and suckling mice.


Variants of measles virus.

Variants of measles virus.


Restriction and modification in Bacillus subtilis. Induction of a modifying activity in Bacillus subtilis 168.


Genetic instability in Drosophila melanogaster. A mutable tandem duplication.


Genetic instability in Drosophila melanogaster. Evidence for insertion mutations.


Establishment of a correlation between physical molecule and genetic map in one segment of the SPP1 chromosome.


The ribosomal proteins of Drosophila melanogaster. Localization of stage specific proteins on the small and large ribosomal subunit.


Mutual regulation of magnified bobbed loci in Drosophila melanogaster.


UV-sensitivity and UV-mutability of infectious lambdaDNA: reactivation, protection and mutability in various assay systems.


Tetanus toxin conformation.

Tetanus toxin conformation.


The survival of microfungi in the nests of tree-sparrow (Passer montanus L.) in the nest-boxes over the winter season.


Glyoxalase system enzyme activity in the liver of rats fed dimethylaminoazobenzene.


Monoclonal IgG-kappa cryoimmunoglobulin in a woman patient with lymphoreticular series hemoblastosis.


Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices.


Language and brain: developmental aspects.


Medicaid prepayment: concept and implementation.


Symptomatic ossification of the posterior longitudinal ligament of the cervical spine. Clinical findings.


Regional health authorities.

Regional health authorities.


Factors in the causation and incidence of ovarian cancer.


The performance of an anti D immunoprophylaxis scheme.


Estriol in pregnancy.

Estriol in pregnancy.


Human prolactin: secretion, regulation and pathophysiology.


Tyrosinase activity of aqueous humour in uveal melanoblastoma.


Reaction of the exposed pulp to Dycal treatment.


Total body potassium estimations in young children: the interpretation of results.


Distribution of PCB and p,p'-DDE residues in Atlantic herring (Clupea harengus harengus) and yellow perch (Perca flavescens) in Eastern Canada--1972.


Pesticide residue levels in soils and crops, FY-70--national soils monitoring program (II).


Residues of the insecticide mirex in terrestrial and aquatic invertebrates following a single aerial application of mirex bait, Louisiana--1971-72.


I-cell disease--mucolipidosis II.

I-cell disease--mucolipidosis II.


Some problems in cancer management. The Michael Williams Lecture 1974.


Isolation of higher molecular weight DNA from Bacillus Cereus T using proteinase K.


Isolation and characterization of a temperature sensitive protein from dog colostrum and milk.


Effect of androgens on the red cell 2, 3 diphosphoglycerate hemoglobin oxygen affinity and red cell mass in mammals.


Virulence measurements of Pseudomonas aeruginosa based on plaque and toxin Z formation in cell culture.


Effect of the H37Ra strain of M. tuberculosis and of a mycobacterial RNA fraction on tumor growth.


The study of shea butter. 4. Stability of medicaments in shea butter ointments and creams.


The action of ergot alkaloids (ergotamine and dihydroergotoxin) on the functional effects of cerebral ischemia in the cat.


The psychiatrist attitudes and therapeutic means when faced with resistant depressions.


A standard system of coordinates for radiotherapy apparatus. HPA Radiotherapy Physics Topic Group.


A theoretical evaluation of plastic dosimetry phantoms.


The application of the logarithmic response of silicon diodes to monitoring beam symmetry and electron energy.


Limitations of the use of the geometric mean to obtain depth independence in scanning and whole body counting.


Pion dose calculations suitable for treatment planning.


Heavy particles in therapy: an application of track theory.


Energy calibration of high energy electrons using a Cerenkov detector and a comparison with different methods.


Spectral dependence of the FeSO4 G-value in DT neutron beams.


Excited states and photobiological properties of potential DNA cross-linking agents, the benzodipyrones.


The hypothalamus and behavioral patterns.


An observational study of hallucinogen-induced behavior in unrestrained Macaca mulatta.


Structure and fiber connections of the hypothalamus in mammals.


Parenteral nutrition.

Parenteral nutrition.


Techniques of total intravenous feeding. A comment to the paper by F. Jarrett.


Protection of microsomal drug biotransformation enzymes against carbon tetrachloride by diethyldithiocarbamate in rat liver.


Theileria lawrencei infection of cattle and African buffalo: evaluation of a buffalo cell culture schizont antigen for the indirect fluorescent antibody test.


Immunogenicity of mycoplasma galactan.

Immunogenicity of mycoplasma galactan.


The economic approach to family health studies.


Experiences with a new test of exocrine pancreatic function in protein deficient Patas monkeys.


The causes of the disappearance and reappearance of induced sublethal mutations in Drosophila melanogaster in the course of a number of generations.


An anatomical study of the pineal body of the vervet monkey (Cercopithecus aethiops).


A histochemical study of the pineal body of the vervet monkey (Cercopithecus aethiops).


Aflatoxin and primary liver cancer.

Aflatoxin and primary liver cancer.


Letter: Effect of measles on the intra-epithelial lymphocyte count of malnourished children.


Incidence and spectrum of malnutrition in paediatric hospital wards.


The treatment of advanced cancer by fast neutrons from the Medical Research Council's cyclotron at Hammersmith Hospital, London.


RBE values of 15 MeV neutrons for responses of pulmonary metastases in patients.


Clinical features of 16 and 50 Mev d leads to Be neutrons.


Comparison between neutron therapy and 60Co gamma ray therapy of bronchial, gastric and oesophagus carcinomata.


The use of californium-252 sources for brachytherapy of human tumours: a preliminary report.


Evaluation of 252Cf neutron emitter for intersitital and intracavitary radiation therapy.


Clinical trials with fast neutrons.

Clinical trials with fast neutrons.


Registration of clinical data and criteria for selection of patients for fast neutron trials.


International cooperation with regard to clinical trials of fast neutron radiotherapy.


The Wisconsin Society of Radiation Oncologists' fast neutron treatment facility.


Plans for neutron radiotherapy in the radiotherapy department of the University Hospital Hamburg-Eppendorf.


Plans for the high-energy, heavy-ion facility (BEVALAC) at Berkeley.


Studies of the proteins elutable from certain artificial surfaces exposed to human plasma.


Variation of RBE as a function of depth in a high energy electron beam in the first millimeters of the irradiated tissues determined by the observation of skin reactions on patients (a clinical trial).


Skin tolerance in rabbits to alpha particle and low energy electron irradiation.


Double-tracer method for determining the proteolytical activity of RES in X-irradiated rats using 131I-labelled albumin microspheres.


Immunodiagnostic tests for bilharziasis. III. Serodiagnosis of Schistosoma haematobium. Infection and influence of chemotherapy on immunodiagnostic tests.


Cross-reacting antigens among some Filariae and other nematodes.


Exoantigens of Trypanosoma cruzi in vivo.


Treatment of chronic cystitis by instillation: experiments employing an artificial model.


Listeria monocytogenes type 5 as a cause of abortion in sheep.


Bovine brucellosis in Nigeria.

Bovine brucellosis in Nigeria.


A standardized autopsy-protocol--problems and solutions.


Cellular breakdown within the arterial wall. An ultrastructural study of the coronary artery in young and aging rats.


Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon.


The influence of the autonomic nervous system on the ultrastructure of the parotid acinar cells. Experimental contribution to the neurohormonal sialadenosis.


The pathology of pulmonary veno-occlusive disease.


Endodermal sinus tumor or orchioblastoma in children and adults.


The structure of the glomerular capillary basement membrane in diabetes mellitus with and without nephrotic syndrome.


Scanning and transmission electron microscopy observations on the surface lining of aortic intimal plaques in rabbits on a hypercholesterolic diet.


Immune insulitis and manifest diabetes mellitus. Studies on the course of immune insulitis and the induction of diabetes mellitus in rabbits immunized with insulin.


Calibres of aorta and pulmonary artery in hypoplastic left and right heart syndromes: effects of abnormal bloodflow?


Immunofluorescence, histochemical and ultrastructural studies for the detection of multiple endocrine polypeptide tumours of the pancreas.


Glomerular changes in acute renal allograft rejection in the dog.


Specificity of inhibition of experimental autoallergic lesions of rat salivary glands.


Demonstration of percellular channels in glamerular podocytes in aminonucleoside nephosis.


The computation of lightness by the primate retina.


Strain tolerance of the vv. cerebri sup. (bridiging veins) calculated from head-on collision tests with cadavers.


A cage for the successful maintenance of tree shrews (Tupaia belangeri) in captivity.


Bovine congenital skeletal defects.

Bovine congenital skeletal defects.


Congenital porta-caval shunts in the dog; a description of three cases.


Clinical and pathological observations on five cases of equine sarcoidosis identified in Romania.


Some aspects of the cardiovascular physiology of the duck.


Blood thiamine levels and transketolase activities as a diagnostic method for thiamine adequacy in cattle.


Proteic content of human uterine secretion.


[Granulomatous cholesterol salpingitis with ceroid accumulation and osseous metaplasia].


Myeloid cell actinomycin binding in human myeloid leukaemia.


Abnormal factor X (factor X Friuli) coagulation disorder. The heterozygote population. A study of 57 subjects.


Hereditary elliptocytosis associated with pernicious anaemia.


Capacity of rat haemopoietic colony-forming units to produce differentiated progeny.


Purpura characterised by thrombasthenia associated with alterations of blood lipids.


Distribution of colony-forming cells in mouse bone marrow.


Concurrent infectious mononucleosis and acute myelocytic leukemia.


Rosette-forming lymphocytes in normals and patients with malignant lymphomas.


A study of lymphocytic beta-glucuronidase in various benign and malignant lymphatic processes.


PHA response of blood and lymph node lymphocytes in vitro in malignant lymphomas.


Water, electrolytes, vitamins and carbohydrates in parenteral nutrition.


Hyperalimentation.

Hyperalimentation.


Therapy with fat emulsion.

Therapy with fat emulsion.


Nutrition of medical patients.

Nutrition of medical patients.


Intravenous amino acid therapy.

Intravenous amino acid therapy.


Parenteral nutrition in uremia.

Parenteral nutrition in uremia.


Enzyme histochemical and ultrastructural alterations in the brains of Friesian calves with GM1 gangliosidosis.


The physiological effects of iron deficiency anaemia and malnutrition on exercise performance in East African school children.


Studies on GM1-gangliosidosis, type II.

Studies on GM1-gangliosidosis, type II.


Multiple sclerosis--a critique and prospective.


The background histories of schoolchildren severely malnourished in infancy.


Lactose malabsorption: its biology and history.


Familial dysautonomia: diagnosis, pathogenesis and management.


Venereal disease in children.

Venereal disease in children.


Standardisation of arthritogenic adjuvants for evaluating anti-inflammatory and immunosuppressant drugs.


An improved fixation procedure for microtubules and microfilaments in cells of the anterior pituitary gland.


Patterns of protein-energy malnutrition in early childhood in Jordan.


Significance of anaerobic spirochetes in the intestines of animals.


Lactobacilli which attach to the crop epithelium of the fowl.


Nutritional features and ecology of predominant anaerobic bacteria of the intestinal tract.


Metabolic interactions among intestinal microorganisms.


Microbial bile acid transformation.

Microbial bile acid transformation.


Serologically active glycolipid families from Mycobacterium bovis BCG. II. Serologic studies on human sera. Serological tests with serologically active glycolipids from Mycobacterium bovis BCG were investigated for their possible use in the diagonis of mycobacterioses. The results were positive with 95 percent of sera from patients with far advanced and moderately advanced tuberculosis, 80 percent of sera from patients with newly diagnosed tuberculosis and 75 percent of patients with atypical mycobacterial diseases. "False" positive serologic reactions were obtained from 4 percent or less. Furthermore, 39 percent of sera from recent tuberculin converters were positive compared with only 9 percent of sera from unselected PPD positive individuals.


The human ultraviolet action spectrum.

The human ultraviolet action spectrum.


Hemolytic anemia of premature infants associated with vitamin E deficiency. Animal model: hemolytic anemia in monkeys deficient in vitamin E.


The effect of practolol on circulatory response after sympathetic stimulation and on plasma growth hormone and insulin levels.


Treatment of partial ruptures of the lateral ligament of the ankle in acute ankle sprains.


The surgical treatment of injuries of the fibular collateral ligaments of the ankle.


[Longitudinally bracketed diaphysis].

[Longitudinally bracketed diaphysis].


The mid-dermis graft - an experimental study.


Vitamin B12 absorption after resection of ileum in childhood.


Letter: effective thyroxine ratio in infants, children, and adolescents.


[Heart diverticula in children: radiological aspects].


[The Laurence-Moon-Bardet-Biedl syndrome. Urographic signs].


Blood group antigens and antibodies in Nigeria.


Iron supplementation in Thai fish-sauce.


Some further observations on the use of a continuous flow apparatus for the maintenance of schistosomes and blood protozoa in vitro.


The effect of vasodilators on calcium kinetics in blood vessels.


Photorespiration in diatoms. The oxidation of glycolic acid in Thallassiosira pseudonana (Cyclotella nana).


The pigments of Flexibacter elegans: novel and chemosystematically useful compounds.


The influence of pharmaca on the oxygen induced constriction of the human umbilical cord artery.


Phytohemagglutinin-induced blastoid transformation of lymphocytes, skin tests and immunoglobulin levels in clinically advanced malignant lymphogranulomatosis.


Collagen fibre bundles of the normal marginal g-ngiva in the marmoset.


Influence of concentration, time, temperature and pH on the retention of chlorhexidine in the human oral cavity after mouth rinses.


The use of amphotericin B to increase the selectivity of media used for isolating oral lactobacilli.


Collagen breakdown in relation to tooth eruption and resorption in the dog.


Vestibular sensory epithelia.

Vestibular sensory epithelia.


Some quantitative features of Drosophila sternite bristle patterns.


Effect of composition of tris-based diluent on survival of boar spermatozoa following deep freezing.


trypsin extractable precipitating antigens of Leptospira interrogans (serotype Biflexa).


Relative specificities of immunoglobulins reacting with axial filament antigens of Leptospira.


The origin of antibody in intestinal secretion of sheep.


A microtitre serum neutralization test for bovine ephemeral fever virus.


Letter: Sarcoptes scabiei infestation of a koala (Phascolarctos cinereus), with probable human involvement.


Immunodeficiency and grouping with thyrogastric autoimmune disease in patients with chronic idiopathic thrombocytopenic purpura.


Studies on equine herpesviruses. 5. Isolation and characterisation of slowly cytopathic equine herpesviruses in Queensland.


Vertebral angiography in bilateral VIII cranial nerve tumours. A report of a case.


Quantitative analysis of ciliary and contractile responses during habituation training in Spirostomum ambiguum.


The alteration of aversive thresholds after chronic administration of two tranquilizing agents.


Ultrastructure of genetic activity in eukaryotic cells.


Radio telemetry of blood flow and pressure measurements in untethered conscious animals.


A selective system for a biochemical analysis of the lethal mutation l(2)me of Drosophila melanogaster.


Nucleotide sequence divergence among DNA fractions of different syngens of Tetrahymena pyriformis.


The specificity of chain interactions among immunoglobulins. Combinations of gamma chains with kappa chains of the same subgroup as in the parent immunoglobulin G. 1. The specificity of combination of heavy and light chains from selected human immunoglobulins was examined in the light of greater structural information than in previous studies. Heavy (gamma) chains from immunoglobulin G (kappa) myeloma proteins were allowed to combine with their homologous light (kappa) chains or with other kappa chains of the same variable-region subgroup. The affinity of each such pairing was assessed by having the test kappa chain compete with a standard population of normal light chains. 2. There was a spread of affinities among the heavy-light pairings with the homologous pairings having an average affinity significantly higher than the heterologous pairings. 3. It follows that (a) the preference shown for homologous heavy-light pairings is not explicable simply in terms of the known subdivisions of the variable and constant regions of the chains, and (b) it is unlikely that those residues specifying the subgroups of kappa-chain variable regions have a predominant role in the formation of interchain bonds with the gamma-chain variable regions.


Analysis of the specific radioactivity of valine isolated from aminoacyl-transfer ribonucleic acid of rat liver.


Disorders of lipid metabolism.

Disorders of lipid metabolism.


Effect of dietary changes on the rates of synthesis and degradation of rat liver fatty acid synthetase.


Studies on the membranes of Bacilli. III. Disaggregation and reaggregation of the membrane components of Bacillus megaterium KM.


Primary drug resistant tuberculosis in Puerto Rico.


Sympathetic receptor functions in liver damage.


Protection of mice against syngeneic lymphomata: I. Use of antibodies. Protection tests using passively administered antibody have been carried out using 2 mouse lymphomata. The classic model ("Gorer System") used alloantiserum which was absorbed in vivo to make it tumour specific before use. In order to provide a system suitable for our work, the model was changed by stepwise transitions to tumour specific immunoglobulin made from xenoantiserum absorbed in vitro, since such a procedure is also applicable to human patients. The time lapse used between challenge and treatment in the allo-system was generally ± 2 h but in the xeno-system could be extended to + 18 h. The xenoantisera could not be absorbed in vivo but required 3 to 5 × 10(3) spleens per 100 ml serum to absorb in vitro to render them tumour specific. The protective antibody was in the IgG (not IgM) fraction of serum. Maximal tumour specific antibody (measured by in vivo protection) appeared after the third injection of rabbits for one lymphoma, but after the fifth for another. The sera were not cross-reactive among 3 lymphomata tested, of which 2 were of the same H-2 genotype.


Protection of mice against syngeneic lymphomata: II. Collaboration between drugs and antibodies. Rabbit anti-mouse tumour cell serum can be made tumour specific by absorption with normal mouse cells and in an in vivo protection test can be shown to have a measurable protective effect on mice against a given number of lethal doses of a lymphoma. Some drugs have been evaluated in this system. When drug treatment is combined with antibody treatment much greater protection can be obtained than when the same amounts of drug or antibody are used alone. It is preferable to administer drug before antibody and with the combined schedule it is possible in the test model to protect all mice from tumour growth, even allowing the tumour up to 48 h "get-away" time before starting treatment.


The American perspective.

The American perspective.


Comparative assessment of microbiological methods for the diagnosis of gonorrhea in women.


Acute and chronic biological false positive reactors to serological tests for syphilis. ABO blood groups and other investigations.


Treatment of gonorrhoea using a combination of intramuscular and oral ampicillin.


Comparison of direct microscopy and culture in the diagnosis of trichomoniasis.


Primary syphilis in the oral cavity.

Primary syphilis in the oral cavity.


Inorganic pyrophosphatase in mineralizing hamster molars. IV. Modification of the inhibition of EDTA, diphosphonates and L-ascorbic acid by Zn2+ and C02+.


Effects of ethylenediaminetetraacetate (EDTA) on urinary excretion of hydroxyproline, calcium and phosphorus in the rat.


Temperature-sensitive mutations in Drosophila melanogaster. XX. Lethality due to translocations.


Phencyclidine: pharmacology and toxicology.


Ultrastructural localization of calcium in the pigeon papillary muscle as demonstrated by cytochemical studies and x-ray microanalysis.


Is primary drug-resistance to major antituberculous agents increasing?


A new antitumor agent, (alphas, 4s, 5r)-alpha-amino-3-chloro-4-hydroxy-4,5-dihydro-5-isoxazoleacetic acid (NSC-176324): preliminary evaluation against L 1210 mouse leukemia in vivo.


Fatal Bacillus cereus pneumonia and sepsis in a child with cancer.


Normal immunoglobulin levels in children who have recovered from meningococcal meningitis.


Prepubescent gonococcal vulvovaginitis.

Prepubescent gonococcal vulvovaginitis.


Vertebral osteomyelitis in a young infant.


Laboratory tests for the assessment of nutritional status.


Erwinia infections in man.

Erwinia infections in man.


A double-blind evaluation of 'Hydergine' and placebo in the treatment of patients with organic brain syndrome and cerebral arteriosclerosis in a nursing home.


A comparison of the onset of bronchodilator activity of metaproterenol and isoproterenol aerosols.


"Immunostaging" as a guideline to immunotherapy in malignancy.


Prazosin in hypertension: a double-blind evaluation with methyldopa and placebo.


The effects of metolazone in the long-term treatment of essential hypertension.


Local treatment of psoriasis and eczema with betamethasone-17,21-dipropionate (Diproderm cream): a double-blind comparsion with fluocortolone caproate, fluocortolone pivalate (Ultralanum cream).


Treatment of essential hypertension with pindolol and clopamide: problems arising from a combined beta blocker and diuretic therapy.


A double-blind comparison of a tetracycline-novobiocin combination antibiotic and tetracycline alone in common infections.


Sulpiride: a chemotherapy for post-traumatic vertigo syndromes.


Double-blind comparison of alophen with its components for cathartic effects.


Viloxiazine--a new antidepressant.

Viloxiazine--a new antidepressant.


Loxapine succinate: a controlled double-blind study in schizophrenia.


Assessment of antipsychotic activity of a butyrophenone analogue, lenperone (AHR 2277).


Pilot open-label study on U-28,774, in anxious in-patients.


Development of the macronuclear anlage in the ciliate Chilodonella uncinate. I. Morphological and cytophotometric studies on the evolution of DNA.


Thyroid function of the aged as viewed from the pituitary-thyroid system.


Serum thyrotropin response to thyrotropin releasing hormone and the concentration of thyroid hormone in patients with hyperfuncting thyroid nodule.


Effect of somatostatin (growth hormone inhibiting factor: GIF) on TRH-induced TSH release in rats.


Glycosphingolipids and glycoproteins in the wild-type and in non-aggregating mutant of Dictyostelium discoideum.


The preparation and characterization of two forms of bovine galactosyl transferase.


Reaction mechanism of D-galactose dehydrogenases from Pseudomonas saccharophila and Pseudomonas fluorescens. Formation and rearrangemnt of aldono-1,5-lactones.


Effects of nitroglycerin on myocardial transmural differences in blood flow, oxygen and carbon dioxide tensions in normal and ischemic canine hearts.


Effect of two different climates on severely burned rats infected with Pseudomonas aeruginosa.


Hemoglobin synthesis inhibiting factor (HSIF). Chemical and biological characterizations.


Pheromones in primate reproduction and social behavior.


Proceedings: Solubilization of adenylate cyclase of rat corpora lutes.


Effect of furylfuramide, a potent mutagen, on reproduction and malformation.


Physiology and pharmacology of PGs in parturition.


Transplacental haemorrhage in abortions.


Protein malnutrition in the rat: its effects on maternal behavior and pup development.


Experiences in the clinical management of amniotic alpha-fetoprotein estimations.


Characterization of Chinese hamsters by metabolic balance, glucose tolerance and insulin secretion.


The diabetic Chinese hamster: in vitro insulin and glucagon release; the ""chemical diabetic";; and the effect of diet on ketonuria.


Morphological characterization of membrane systems in A- and B-cells of the Chinese hamster.


Segmental demyelination in the distal peripheral nerves of chronically diabetic Chinese hamsters.


The polyol pathway for glucose metabolism in tissues from normal, diabetic, and ketotic Chinese hamsters.


Hepatic and renal protein synthesis in normal, diabetic and ketotic Chinese hamsters.


Morphologic abnormalities observed in retina, pancreas and kidney of diabetic Chinese hamsters.


Effect of diet limitation on the development of diabetes in prediabetic Chinese hamsters.


Aortic glucose metabolism in the diabetic Chinese hamster.


Epidemiology of Chinese hamsters and preliminary evidence for genetic heterogeneity of diabetes.


Characterization of diabetes mellitus in South African hamsters (Mystromys albicaudatus).


Effects of population size and selection intensity on responses to disruptive selection in Drosophila melangaster. Disruptive selection for sternopleural bristle number with opportunity for random mating was done in the four treatment combinations of two population sizes (40 pairs and 8 pairs of selected parents) and two selection intensities (1 in 40 and 1 in 2). In each generation, matings among selected parents were observed in a mating chamber, and progeny collected separately from each female parent. In the high number, high selection intensity treatment, divergence between the high and low parts ceased about generation 11. The isolation index increased rapidly to generation 3, but then fluctuated to termination of the population at generation 17. The overall isolation index was significant, indicating a real tendency to assortative mating. The failure of the isolation index to increase after generation 3 was attributed to lower average mating fitness of high males (due to inbreeding) and reduced receptivity of low females (due to a homozygous lethal gene with a large effect on sternopleural bristle number in heterozygotes). In the two low number treatments, isolation indices fluctuated from generation to generation with no obvious trends, and none of the overall isolation indices were significantly different from zero. The high number, low selection intensity treatment showed very little divergence, and one of the replicates showed, in contrast with expectation and the high number, high selection intensity treatment, a significant tendency to disassortative mating. Intense disruptive selection may lead to assortative mating.


Steroid induction of the mRNA for hepatic tryptophan oxygenase.


Inhibitors of mammalian protein synthesis.


Pharmacology of Sintamil metabolites.

Pharmacology of Sintamil metabolites.


Electron microscopic autoradiographic studies on polytene nuclei of Drosophila melanogaster: Part I. Replication and its relationship with nuclear membrane.


Effect of mutation on the amylolytic and proteolytic activity of Bacillus subtilis isolated from domestic waste water.


Immunoglobulins in health and disease. II. IgE concentrations in the sera of patients with bronchial asthma.


Peroxidase-dependent oxidation of tyrosine to melanin in leucodermic vitiligenous skin.


Some anthropologic investigations of interest to oral surgeons.


Surgical and orthodontic treatment of cleidocranial dysostosis.


Results of apicoectomy of maxillary canines, premolars and molars with special reference to oroantral communication as a prognostic factor.


Experimental reconstruction of the mandibular joint.


A radiographic and clinical follow-up study of 150 oroantral communications.


Use of propylic ester of p-hydroxy-benzoic acid after removal of impacted mandibular third molars.


Cilnical experiences in oral surgery using a new self-aspirating injection system.


Evaluation of carticaine - a new local analgesic.


The effect of mucin-containing artificial saliva on severe xerostomia.


A case of gigantiform cementoma.

A case of gigantiform cementoma.


Report on an oral, pigmented, squamous cell carcinoma.


Some analyses of exsheathing fluid from infective Haemonchus contortus larvae from Ontario.


Evidence of a rat-snake life cycle for Sarcocystis.


Stimultaneous determination of effective renal plasma flow and glomerular filtration rate by the "single shot" method.


Enterovirus etiology of the 1970 Singapore epidemic of acute conjunctivitis.


Genetic tests on Drosophila melanogaster with polychlorinated biphenyls (PCB).


Changes of zeste phenotype induced by autosomal mutations in Drosophila melanogaster.


Stabilising selection in constant and fluctuating environments.


Phenotypic observations on modification of position-effect variegation in Drosophila melanogaster.


Studies on the nature and function of polygenic loci in Drosophila. I. Comparison of genomes from selection lines.


Studies on the nature and function of polygenic loci in Drosophila. II. The subthreshold wing vein pattern revealed in selection experiments.


Immunocytochemical demonstration of intestinal alkaline phosphatase.


The mechanism of metal binding to glutaraldehyde-fixed noradrenaline-storing adrenomedullary granules.


Proceedings: Numbers of neurons through full depth of neocortex.


Evidence for the association of RNA with the ciliary basal bodies of Tetrahymena.


The antagonistic effects of antimitotic agents on contraction and re-extension in the ciliate Spirostomum ambiguum.


Limpet haemocytes. III. Effects of cytochalasin B and colchicine on cell spreading and aggregation.


Penicillin control of swelling and pain after periodontal osseous surgery.


Schizophrenic response to affectivity in word definition.


Tonsillolith and elongated styloid.

Tonsillolith and elongated styloid.


A high frequency of fertilization in premature and mature coelomic toad eggs after enzymic removal removal removal of vitelline membrane.


Intracellular calcium binding and release in frog heart. The capacities and affinities of intracellular calcium-binding sites have been studied in frog ventricles, in which the concentration of Ca(++) in the sarcoplasm can be controlled as a result of treatment with EDTA. The total calcium content of calcium-depleted and nondepleted muscles at rest and muscles generating considerable tension was 0.8, 1.4, and 5.4 micromol/g of muscle, respectively. Net movement of calcium into or out of the cells occurred without change in tension when the sarcoplasmic concentration of Ca(++) was either of two values, less than 10(-7) M or approximately 5 x 10(-7) M. These data can be explained by the presence of two groups of intracellular calcium sinks which compete with the contractile proteins, one with a capacity of about 0.6 micromol/g and an affinity constant greater than 10(7) M(-1) and a second with a capacity of 4.0 micromol/g and an affinity constant of about 2 x 10(6) M(-1). The higher affinity calcium is released by anoxia, oligomycin, or abrupt changes in sarcoplasmic Ca(++). Muscles soaked in Sr-Ringer's contain electron densities in the sarcoplasmic reticulum and to a lesser extent in the mitochondria.


Immunochemical identification of a new molecular form of acid phosphatase of host origin arising during infection of potato tubers by Phytophthora erythroseptica Pethybr.


The properties and host range of male-specific bacteriophages of Pseudomonas aeruginosa.


Nitrification by aflatoxigenic strains of Aspergillus flavus and Aspergillus parasiticus.


Establishment of a limited rumen flora in gnotobiotic lambs fed on a roughage diet.


The utilization of Bacillus megaterium and the release of a lytic enzyme by three Epidinium spp. isolated from the rumen.


The metabolism of starch, glucose, amino acids, purines, pyrimidines and bacteria by three Epidinium spp. isolated from the rumen.


The metabolism of Epidinium ecaudatum caudatum and Entodinium caudatum as shown by autoradiography in the electron microscope.


A co-operative numerical analysis of cultures considered to belong to the 'rhodochrous' taxon.


Mucopeptide synthesis by rod mutants of Bacillus subtilis.


Temperature sensitivity of sporulation in Bacillus cereus.


Prostaglandins and the anti-inflammatory activity of a human plasma fraction in carrageenan-induced paw oedema in the rat.


Ionic relations and electrical properties of isolated oocytes of Bufo bufo with special reference to removal of extracellular chloride. 1. The efflux rate coefficients of sodium, potassium and chloride from immature oocytes of the toad Bufo bufo have been measured and found to be respectively, 0.0069, 0.0023 and 0.0034 min(-1).2. Replacement of external chloride by sulphate resulted in a fall in chloride efflux of about 50%. This has been interpreted in terms of exchange diffusion.3. The membrane conductance has been measured and found to be 0.14 x 10(-3) mhos cm(-2) in good agreement with the value calculated from the flux data, 0.12 x 10(-3) mhos cm(-2), after taking account of the chloride exchange diffusion fraction.


The effect of holding potential on the asymmetry currents in squid gaint axons. 1. Asymmetry currents were recorded from intracellularly perfused squid axons subjected to an equal number of exactly equal positive and negative voltage clamp pulses. The asymmetry currents consisted of an on-response at the beginning of the pulses and an off-response at the end of the pulses.2. The asymmetry currents were markedly reduced by 30 mM glutaraldehyde applied internally.3. Clamp pulses of varying height, superimposed on a holding potential of - 80 to - 100 mV, were used to study the voltage and time dependence of the asymmetry current. The magnitude of the on- and off-response increased with increasing pulse height along a sigmoid curve. The time constants of the on- and off-response depended on the potential during the depolarizing pulses; the time constant of the on-response had a maximum at an internal potential of - 12 mV, the time constant of the off-response was largest at positive internal potentials.4. Holding the membrane at a potential of - 80 to - 100 mV for several minutes led to a slow increase of the size of the asymmetry current.5. Changing the holding potential from - 80 or - 100 mV to a less negative potential caused a decrease of the asymmetry current. At holding potentials less negative than - 65 or - 60 mV the asymmetry current reversed its sign: the transient current at the beginning of the pulses turned into an inward current and the transient current at the end of the pulses became outward. No inactivation of the asymmetry current was seen in the range of holding potentials studied (V < - 3 mV).6. The results are generally consistent with the idea that the asymmetry currents are in some way related to the opening and closing of the Na gates; they suggest, however, that the asymmetrical charge movement does not simply reflect the voltage and time dependence of the m system.


Haemogregarina pseudemydis n. sp. (Apicomplexa: Haemogregarinidae) and Pirhemocyton chelonarum n. sp. in turtles from Louisiana.


Cryptosporidium anserinum sp. n. (Sporozoa) in a domestic goose Anser anser L., from Iowa.


Fine structure of the cyst and some sporulation stages of Ichthyosporidium (Microsporida).


Terebrospira chattoni sp. n., a parasite of the endocuticle of the shrimp Palaemonetes pugio Holthuis.


Diplodinium flabellum: occurrence and numbers in the rumen of sheep with a description of two new subspecies.


Ultrastructure of symbiotic bacteria in normal and antibiotic-treated Blastocrithidia culicis and Crithidia oncopelti.


Besnoitia jellisoni in macrophages and cysts from experimentally infected laboratory mice.


Ultrastructural localization of acid phosphatase in starved Tokophrya infusionum.


Studies of membrane formation in Tetrahymena pyriformis. VIII. On the origin of membranes surrounding food vacuoles.


Isolation and characterization of kinetoplast DNA networks and minicircles from Crithidia fasciculata.


Beta-oxidation in glyoxysomes from Euglena.


Isolation of kinetoplast-mitochondrial complexes from Leishmania tarentolae.


Immunogenicity of the delta-haemolysin of Staphylococcus aureus.


Candida serology in open-heart surgery.

Candida serology in open-heart surgery.


Antibiotic-resistant gram-negative bacilli in the faeces of neonates.


Rapid group and species identification of enterococci by means of tests with pooled phages.


Immunoglobulin levels as related to age in nonhuman primates in captivity. I. Chimpanzees.


Immunoglobulin levels as related to age in nonhuman primates in captivity. II. Rhesus monkeys.


Restraining chair and face mask for inhalation toxicology studies in primates.


Cutis verticis gyrata in a Chinese mental defective.


Letter to editor: Subunit arrangements in bacterial flagella.


A study of the histidine residues of human carbonic anhydrase B using 270 MHz proton magnetic resonance.


The effects of fusidic acid on growth, ribosome synthesis and RNA metabolism in Escherichia coli.


Infant malnutrition in Africa: the rôle of artificial milk feeds.


Measuring the recovery rates of malnourished children from their weight-gains. Part I: review of existing methods.


Measuring the recovery rates of malnourished children from their weight-gains. Part II: discussion of a new technique.


Studies on the modification of the live AIK measles vaccine. I. Adaptation of the further attenuated AIK measles virus (the strain AIK-L33) to chick embryo cells.


Protein composition of cell and forespore membranes of Bacillus subtilis.


Unusual fracture and orthopedic problems.


Antimicrobial activity of cultured plant cells and tissues.


Hydrophobic chromatography.

Hydrophobic chromatography.


Affinity density perturbation.

Affinity density perturbation.


Pteroyllysine-agarose in the purification of dihydrofolate reductase.


Isolation of beta-galactosidase by chromatography.


Group-specific separation of glycoproteins.


Alpha-lactalbumin-agarose. A specific adsorbent for a galactosyltransferase.


Use of thyroxine in affinity chromatography.


Covalent affinity chromatography of penicillin-binding components from bacterial membranes.


Purification of thymidylate synthetase with 2'-deoxyuridylate-agarose.


Affinity chromatography of thermolysin and other neutral metalloendopeptidases.


Editorial: The hunger striker.

Editorial: The hunger striker.


Effects of dexamthasone and secobarbital on the pituitary response to thryotropin releasing hormone (TRH) in man: synergistic inhibition of thyrotropin (TSH) release.


Gentamicin by intravenous bolus injection.


Physical aspects of supervoltage x-ray therapy.


Chemotherapy of malignant mesothelioma.

Chemotherapy of malignant mesothelioma.


The diagnosis of subclinical mastitis in lactating cows: a comparison of cytological methods and a monovalent radial immunodiffusion test.


Chemoprophylaxis of bladder cancer recurrence: immunological aspects.


Residues of organochlorine insecticides and PCBs in samples of Norwegian butter 1972.


Membrane attachment of the chromosome in Bacillus subtilis mutants temperature-sensitive in DNA replication. We have examined three mutants of Bacillussubtilis temperature sensitive in DNA initiation and one temperature sensitive in DNA elongation, in order to investigate whether these lesions can cause or can result in a detachment of the membrane-bound chromosomal region. Our results argue against any effect of the mutations examined on the association between the chromosome and the membrane.


Radiotherapy.

Radiotherapy.


Acute barbiturate poisoning in young epileptics.


Accuracy of measurements of potassium content of monkeys by in vivo body counting as compared to chemical analysis.


The use of nuclear track detectors in the design of neutron collimators and scatterers.


A kinetic study on inorganic polyphosphate glucokinase from Mycobacterium tuberculosis H37RA.


The comparison of thyrotropin releasing hormone, luteinising hormone-releasing hormone and placebo in depressive patients using a double-blind cross-over technique.


Sex and long-term care.

Sex and long-term care.


Thio-tepa and endoxan in combined treatment of breast cancer (cooperative trial).


Results of faecal examinations with special regard to vibrios in tourists returning from the same area as a verified case of cholera.


Tobramycin treatment of pseudomonas aeruginosa infections in cystic fibrosis.


Meningococcemia due to neisseria meningitidis serogroup D.


In vitro assay of malignant transformation by the oncogenic adenovirus SA7.


The presence of Capillaria hepatica (Bancroft, 1893) Travassos, 1915 in a vervet monkey Cercopithecus aethiops.


Pattern of biochemical and immune recovery in protein calorie malnutrition.


The role of releasing hormones in the diagnosis of hypopituitarism. An analysis of 9 patients.


Oesophageal motor dysfunction in patients with diverticula of the mid-thoracic oesophagus.


Fibrinogen-fibrin-related antigen pattern in human blood. Differences between plasma and serum from pateints with disseminated intravascular coagulation.


Rapid detection and quantitation of precipitating streptokinase-antibodies.


Indirect measruement of streptokinase concentration in the plasma of patients undergoing fibrinolytic treatment.


Long-term effects of ionizing radiation on drosophila midgut mitochondria.


Dose distribution measurements in electron lens therapy with a 45 MeV betatron.


The treatment of peritonitis in patients with chronic indwelling catheters.


A compact portable prosthesis for total parenteral nutrition (t.p.n.): ambulatory parenteral feeding in the hospital and home.


Serum middle molecule levels in uremia during long term intermittent hemoperfusions with the acac (coated charcoal) microcapsule artificial kidney.


Lankesterella from an East African crowned crane Balearica pavonina gibbericeps.


Swine vesicular disease: a serological vurvey of pigs presented for slaughter.


Vaccinal immunity to Marek's disease in bursectomised chickens.


Placental structure and transmission of maternal immunity.


Extrarenal lipid inhibitors of human erythropoietin.


DNA replication of human acute leukemia cells cultured in vitro.


Haemolysis and erythrocyte lipids in thalassaemia major.


Haemoglobin E variants and pregnancy in Malaysian aborigines.


Factor X survival and therapeutic factor X levels in the abnormal factor X (factor X FRIULI) COAGULATION DISORDER.


Proliferation of erythroblasts in refractory anaemia. A combined autoradiographic and cytophotometric study.


In vitro response of bone marrow cells to erythropoietin in aplastic anemia.


67Ga scanning in the staging of Hodgkin's disease.


Structure and function of haemoglobin Tacoma (beta 30 Arg yields Ser) found in a second family.


Congenital dyserythropoietic anaemia type II. Clinical and ultrastructural study.


Hereditary disorders of bilirubin metabolism.


The activity of intestinal disaccharidases and dipeptidases in rats with chronic renal insufficiency.


Histochemical studies on the morphology of the Golgi apparatus and on the distribution of hexokinase, amylophosphorylase, cholinesterases, and monoamine oxidase in the area postrema of the Asiatic chipmunk, Tamias sibiricus asiaticus (T. orientalis).


The surface of dissected neurons, neurons in smears, cultivated cells and sections as studied by means of scanning electron microscopy.


Quantitative aspects of the colloidal iron reaction.


Histochemical analysis of thiamine pyrophosphatase activity in the developing molar tooth of the neonatal swiss albino mouse.


Ancient ophthalmological agents.

Ancient ophthalmological agents.


Proceedings: Visual information processing, colour vision and spatial localization.


Modified method of demonstration for zinc in tissues and its mode of existence.


The treatment of hypercatabolic acute renal failure by adequate nutrition and haemodialysis.


A brain-specific water-soluble antigen in homogenates of cat cerebral cortex.


The value of histology, culture and guinea pig inoculation examination in osteo-articular tuberculosis.


Neuropathological and biochemical studies in Fabry's disease.


Bowel diseases involving local immunoglobulin systems.


Influence of synthetic polynucleotides and interferon on in vitro growth of cells derived from a mouse sarcoma.


Effects of radiation therapy on blood-borne leucocytes in patients with mammary carcinoma.


Atherosclerosis in pigeons and squirrel monkeys.


Absorption of polymyxin E (colistin) by Corynebacterium diphtheriae.


Social factors and atherosclerosis.

Social factors and atherosclerosis.


Immunologial aspects of atherosclerosis.


On species of leucocytozoon.

On species of leucocytozoon.


Recent advances in antimalarial chemotherapy and drug resistance.


Trypanosoma cruzi and virological studies in idiopathic cardiomyopathy in Cali, Colombia. During a 10-year period a series of 114 patients was studied to determine if Trypanosoma cruzi and arboviruses could be the etiologic agents of idiopathic cardiomyopathy (ICM) in Cali, Colombia. In this area, ICM (together with rheumatic and artherosclerotic cardiopathy) represents the second most frequent cause (determined by necropsy) among adult patients with cardiopathies, hypertension being the first. No association was observed between ICM and any of the arboviruses assessed by hemagglutination tests. Only 10 of 114 cases (8.7%) showed positive seroparasitological tests for T. cruzi. Autopsy was performed in 4 of these 10 cases; 1 had Chagas myocarditis and the other 3 were patients with non-inflammatory ICM. In all 9 T. cruzi-negative cases the autopsies showed non-inflammatory ICM lesions. In contrast to typical Chagas cases, the most frequent EKG change in ICM is left bundle branch block rather than right. Since the EKG varies within either group, this distinction may not be valid in individual cases. Because of the similarities in clinical characteristics and variations in EKG between Chagas myocarditis and ICM, it is suggested that autopsies should be done in populations in endemic areas of T. cruzi to assess the frequency of ICM and its importance in the differential diagnosis of Chagas myocarditis.


Evidence for defective immunoglobulin metabolism in severe renal insufficiency.


The prevalence of trypanosomes and microfilariae in Panamanian monkeys. A total of 3,523 wild caught monkeys from Panama was examined for blood parasites from August 1968 through June 1972. Trypanosomes or microfilariae were observed in the blood of 31.1% of the monkeys. Mixed infections, with microfilariae and trypanosomes, were detected in 6.6% of the animals. Trypanosoma cruzi was found in marmosets. Saguinus geoffroyi (12.2%), in white-faced capuchins, Cebus capucinus (5.0%), in squirrel monkeys, Saimiri sciureus (1.7%) and in black spider monkeys, Ateles fusciceps (1.2%). Trypanosoma rangeli was found in S. geoffroyi (55.8%) and C. capucinus (12.5%). Other trypanosomes found in Panamanian monkeys included T. minasense, and T. mycetae. Saguinus geoffroyi showed the highest infection rate (88.9%) with trypanosomes and/or microfilariae; trypanosomes were seen in 68.1%, and microfilariae in 73.0%, of the animals examined. The marmosets, white-faced capuchins, and squirrel monkeys should be considered as significant hosts of T. cruzi in sylvatic habitats and may serve as reservoir hosts of Chagas' disease in Panama. The microfilariae seen in monkeys from Panama were tentatively identified as larval forms of Dipetalonema gracile in Aotus trivirgatus; D. obtusa in C. capucinus and S. geoffroyi; and D. marmosetae in Alowatta villosa, C. capucinus, A. trivirgatus, S. sciureus, A. fusciceps, and S. geoffroyi.


Single and repeated infections of grivet monkeys with Schistosoma mansoni: parasitological and pathological observations over a 31-month period. Groups of 6 to 8 grivet monkeys (Ceropithecus aethiops aethiops), each of which had been exposed to 600 cercariae of Schistosoma mansoni, were killed 3, 6, and 31 months after exposure. Other groups of monkeys were repeatedly challenged with cercariae beginning 4 or 23 months after the initial infection, and were killed 31 months after the first exposure. Peripheral blood leukocytes, eosinophiles, and schistosome eggs passed in the feces were determined during the course of the infection. At autopsy, gross and histopathologic observations were made, worms were recovered by perfusion, and the number of eggs in the tissues was determined by digestion. Monkeys became acutely ill about 8 weeks after the initial exposure, and death was attributed to acute'toxemic' schistosomiasis in 4 of 46 infected animals. The symptoms and signs of the acute phase did not recur with reinfection. Most subsequent natural deaths were caused by Klebsiella infection which occurred in both infected and control  monkeys and did not appear to be related to the schistosome infection. Relatively stable infections were found after a single exposure to cercariae, with only a slight decrease in worm numbers and moderate decrease in egg passage after 31 months. With repeated reinfection, only 19% of challenge cercariae developed into adult worms. Oviposition by these worms was delayed and the rate of oviposition was substantially less than in monkeys infected only once. Eggs deposited in the tissues were rapidly destroyed. The calculated rate of oviposition varied from  658 eggs/day per female 3 months after a single infection to 299 eggs/ day per female 31 months after repeated infections. Although very heavy infections were present in repeatedly infected monkeys, only slight hepatic fibrosis was seen and no portal hypertension or portal-systemic collateral circulation developed. Severe intestinal disease was present in only two monkeys. The remaining animals had little diarrhea after the acute phase, and there was only slight loss of plasma protein into the feces 31 months after exposure.


Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. I. Clinical course. Fifteen  grivet monkeys, Cercopithecus aethiops, were infected with an Ethiopian strain of Borrelia recurrentis, the causative agent of louse-borne relapsing fever. An initial spirochetemia occurred in all. Inactivity, fever, and leukocytosis accompanied the infections. Eight of the monkeys experienced 1 relapse and 1 monkey had 2 relapses. The relapses tended to be less severe than the initial infections. The only deaths, however, occurred in 2 of the 3 monkeys with severe relapses. The clinical course of the experimental infection in grivet monkeys closely resembles that of natural infections in man.


Administration and evaluation of rural health services. I. A tetanus control program in Haiti. Tetanus has been a public health problem of major importance in rural Haiti. Energetic preventive measures by a rural Haitian hospital were successful in controlling the problem only after immunization services were made easily available to the entire population served by the hospital. This was accomplished by a program which carried the services to the market places and villages of the region. The program developed several new categories of auxiliary personnel who were recruited locally and trained on the job. These personnel were utilized in a program which incorporated preparatory publicity, timing, handling of large crowds in open surroundings, education, record keeping, follow-up and evulation as well as the technical matters concerning the giving of injections. The program sharply reduced the number of admissions to the hospital for the treatment of tetanus. Evaluated on the basis of hospitalizations avverted the program cost only 1/9 the value of the 50,000 hospital days of care for the tetanus cases it prevented. A rural hospital in Haiti -- the Albert Schweitzer Hospital of Deschapelles -- initiated an energetic preventive program to deal with the public health problem of tetanus.  The program was successful in controlling the problem only after immunization services were made easily available to the entire population served by the hospital.  The program offered services in the market places and villages of the region.  Several new categories of auxiliary personnel were recruited locally and trained on the job.  The program incorporated preparatory publicity, timing, handling of large crowds in open surroundings, education, record keeping, follow-up and evaluation and the technical administration of the injections.  The program was responsible for a marked reduction in the number of admissions to the hospital for the treatment of tetanus.


Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. II. Pathology. Nineteen grivet monkeys, Cercopithecus aethiops, were infected with the spirochete of louse-borne relapsing fever, Borrelia recurrentis, and killed at various intervals following inoculation: 4 during the initial spirochetemia; 4 during remission; 3 during relapse; 2 that were dying following severe relapses; and 6 during convalescence. The histologic changes of histiocytic myocarditis, multiple microabscesses replacing the nodular white pulp of the spleen, and hepatitis with foci of midzonal necrosis were similar to those seen in humans. These changes are rarely seen in other infectious diseases and suggest a specific toxic effect.


Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. III. Crisis following therapy. Eight grivet monkeys infected with Borrelia recurrentis received tetracycline (12.5mg/kg body weight) on the 3rd or 4th day of spirochetemia. Leukopenia, fever, hyperpnea, and tachycardia developed within 2 hours as spirochete counts fell to undetectable levels. These events closely simulated the crisis in human louse-borne relapsing fever in both timing and extent.


Abnormal patterns of ossification in foot bones of rat fetuses induced by cyclophosphamide.


Synthesis of alpha-functional nitrosamines.


Dinitrogen(octaethylprophinato)tetrahydrofuranosmium(II): a nitrogen-carrying metalloporphyrin.


Purification and immunological quantification of human pancreatic lipase.


The effect of high salt concentrations upon cytochrome C, cytochrome B5, and iron-EDTA reductase activities of liver microsomal NADPH-cytochrome C reductase.


Practolol in angina pectoris: a double-blind ergometric study.


Penicillin-resistant mechanisms in Pseudomonas aeruginosa: effects of penicillin G and carbenicillin on transpeptidase and C -alanine carboxypeptidase activities. A membrane fraction from Pseudomonas aeruginosa KM 338 was shown to catalyze in vitro peptidoglycan synthesis from uridine 5'-diphosphate-N-acetylmuramyl-l-alanyl-d- glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine and uridine 5'-diphosphate-N-acetylglucosamine. Synthesized peptidoglycan was partially cross-linked by transpeptidation, which was accompanied by the release of d-alanine. This reaction was strongly inhibited by 25 and 50 mug of penicillin G and carbenicillin per ml respectively, whereas the intact cells were relatively resistant to penicillins (minimal inhibitory concentration of penicillin G and carbenicillin, 30 and 0.125 mg/ml, respectively). Soluble d-alanine carboxypeptidase present in P. aeruginosa KM 338 was studied as well, which was found almost completely inhibited by penicillin G and carbenicillin (10 mug/ml).


Immunogical study of anti-beta-lactamase antibodies by acidimetric methods. A beta-lactamase was extracted from an Escherichia coli K-12 strain carrying the R-TEM plasmid and has been purified by affinity chromatography. Antisera to this enzyme were prepared in the rabbit, and the enzyme-antibody neutralization reaction has been evaluated with acidimetric methods (pH stat or pH meter). Under defined experimental conditions, it is now possible to clearly illustrate the enzyme-antibody reaction by means of accurate, rapid, and simple-to-perform methods. These methods are in accord with the specificity of the two reactive partners and allow the detection of the enzyme in a crude bacterial extract which would eventually contain more than one beta-lactamase.


Antimicrobial actions of hexachlorophene: inhibition of respiration in Bacillus megaterium. Hexachlorophene (HCP) inhibits both endogenous and exogenous respiration (oxygen uptake) in Bacillus megaterium, without sparing by any of several substrates. The inhibition is maximal when the cells are treated with 8 mug of HCP per mg of cells (dry weight), which corresponds to the minimal lethal dose. Levels as low as 2 mug/mg are inhibitory but not lethal. HCP also inhibits the respiration of isolated B. megaterium membranes and can act on several components of the electron transport chain in the membranes and on soluble enzymes. Although both forms of nicotinamide adenine dinucleotide, reduced form dehydrogenase and malic dehydrogenase are inhibited by HCP, they are less susceptible than is oxygen uptake. The site of maximal sensitivity is nearer the terminal electron acceptor, but the exact location depends on the cytochrome composition of the membranes. If cytochromes b(1), a, and a(3) are present, but not o, HCP inhibits electron transport on the substrate side of cytochrome b(1); if cytochromes b(1), a(3), and o are present, but not a, the inhibition occurs on the oxygen side of cytochrome b(1). Exogenous menadione, an analogue of menaquinone, reverses the inhibition in both circumstances. The primary lethal action of HCP thus appears to be respiratory inhibition at a site within the membrane-bound part of the electron transport chain.


Effects of sublethal concentrations of benzylpenicillin on Pseudomonas aeruginosa. Pseudomonas aeruginosa produces a low basal level of beta-lactamase (0.002 to 0.004 IU/mg of protein when benzylpenicillin is used as substrate). The beta-lactamase specific activity can be increased several hundredfold by growing the bacteria in the presence of beta-lactam antibiotics. This induction was studied in Pseudomonas aeruginosa 1822s. The single-cell resistance to benzylpenicillin was 750 mug/ml. In liquid culture all concentrations of benzylpenicillin tested (25 to 2,000 mug/ml) affected the bacteria similarly: beta-lactamase formation was induced, the cells became cholate sensitive, growth rate decreased, filaments were formed, and beta-lactamase was excreted. The effect appeared earlier the higher the concentration of the antibiotic. Most of the effects obtained are concerned with the functioning of the outer membrane. The excretion of beta-lactamase seems to be due to an opening of the periplasmic volume rather than to lysis of the cells. Carbenicillin gave the same effects as benzylpenicillin at the same concentrations; the 10-fold lower resistance to carbenicillin than to benzylpenicillin can be explained by the inability of the inducible beta-lactamase to hydrolyze carbenicillin. The induced beta-lactamase was first cell bound and to a great extent located in the periplasmic volume, but later it was excreted into the medium. This extracellular activity was responsible for the detoxification of the medium. This is analogous to the behavior of gram-positive bacteria rather than to that of Enterobacteriaceae.


Induction kinetics of beta-lactamase biosynthesis in Pseudomonas aeruginosa. The induction of beta-lactamase in Pseudomonas aeruginosa 1822s was studied using benzylpenicillin as inducer. The specific rate of beta-lactamase formation was constant throughout an induction experiment. Above a threshold (20 mug/ml), the specific activity increased linearly with the concentration of the inducer. Removal of the inducer resulted in a rapid cessation of beta-lactamase biosynthesis. Inhibition of protein synthesis by starvation for a required amino acid or by the addition of chloramphenicol also led to an instantaneous arrest in enzyme formation. In the absence of inducer, a basal beta-lactamase activity was formed. The basal and the induced enzymes seem to be identical since they had the same substrate profile, electrophoretic mobility, and molecular weight. In all these respects, induction of beta-lactamase in Pseudomonas aeruginosa is analogous to induction of the lac operon in Escherichia coli. However, there was a long, concentration-dependent lag before beta-lactamase was induced. This can be explained by the outer penetration barrier decreasing the rate of inducer uptake. The lag was significantly shorter for lysozyme-ethylenediaminetetraacetic acid-produced spheroplasts than for intact cells. Induction was obtained with all beta-lactam antibiotics tested, but not with other agents affecting the cell envelope.


Chloroquine-resistant Plasmodium falciparum: effect of substrate on chloroquine and amodiaquin accumulation. Glucose stimulates the high-affinity processes of chloroquine and amodiaquin accumulation in owl monkey erythrocytes infected with a chloroquine-susceptible strain of Plasmodium falciparum. Although these erythrocytes have greater ability to accumulate amodiaquin than chloroquine, glucose has relatively less effect on amodiaquin accumulation than on chloroquine accumulation. In contrast to these findings with chloroquine-susceptible P. falciparum, glucose stimulates amodiaquin but not chloroquine accumulation in erythrocytes infected with chloroquine-resistant P. falciparum. This lack of function of a substrate-dependent component of chloroquine accumulation distinguishes chloroquine-resistant from chloroquine-susceptible P. falciparum.


Properties of an R plasmid in Pseudomonas aeruginosa producing amikacin (BB-K8), butirosin, kanamycin, tobramycin, and sisomicin resistance. Pseudomonas aeruginosa strain GN315, producing kanamycin acetyltransferase, can transmit a plasmid determining resistance to kanamycin, amikacin (BB-K8), butirosin, tobramycin, and sisomicin, but not gentamicin, to other pseudomonas strains. This plasmid, pMG5, belongs to the same incompatibility group as plasmids determining gentamicin resistance in P. aeruginosa via gentamicin acetyltransferase I. Like other members of this group, it also confers resistance to Hg(2+), organomercurials, and certain deoxyribonucleic acid phages. When pMG5 is introduced into a cell carrying a related R factor, some transconjugants can subsequently cotransfer new combinations of resistance determinants as though recombinant plasmids had been formed.


Penicillin: reversible inhibition of forespore septum development in Bacillus megaterium cells. Benzylpenicillin inhibits the development of the forespore septum in sporulating Bacillus megaterium cells. The inhibitory effect is a function of the duration of exposure to the antibiotic and is completely reversible by penicillinase. Under the incubation conditions employed, less than 20% of the covalently bound antibiotic is released from the cells. The penicillin which remains bound to the cells after treatment with penicillinase may be necessary but is not sufficient for the effect; unbound antibiotic in the sporulation medium is also required.


Ecological application of antibiotics as respiratory inhibitors of bacterial populations. Two terregenous and four marine bacterial isolates were treated with six antibiotics and antibiotic combinations. Comparisons made between responses of cells in early and late logarithmic and stationary growth phases indicated variable sensitivity to the agents. Bacteria in stationary and late log-phase cultures exhibited the greatest resistance, whereas the early log-phase cells exhibited greatest antibiotic susceptibility. We conclude that the tested antibiotics cannot be used for ecological purposes to delineate bacterial respiration in mixed microbial communities.


Antagonism of lactic streptococci toward Staphylococcus aureus in associative milk cutures. The inhibition of growth of Staphylococcus aureus by lactic streptococci in associative cultures in milk was not due to hydrogen peroxide produced by the streptococci. Dialyzed whey from the milk culture of lactic streptococci was more inhibitory than dialyzed whey from milk acidified with lactic acid, indicating that material other than lactate was also involved. Analyses of cation and anion exchange fractions from the dialyzed whey showed that only the neutral fraction was inhibitory.


Detecting the enterotoxigenicity of Staphylococcus aureus strains. An optimal sensitivity plate method for examining large number of staphylococcal strains for production of the known enterotoxins (A-E) is presented. Small volumes of relatively concentrated enterotoxin are produced by the semi-solid agar, cellophane-over-agar, or sac culture techniques. Detection of the enterotoxin in the supernatant fluid is accomplished with the optimal sensitivity plate method. In this method small plastic petri dishes (50 mm) were used for a modified Ouchterlony of high sensitivity.


Agricultural plants and soil as a reservoir for Pseudomonas aeruginosa. Pseudomonas aeruginosa was detected in 24% of the soil samples but in only 0.13% of the vegetable samples from various agricultural areas of California. The distribution of pyocin types of soil and vegetable isolates was similar to that of clinical strains, and three of the soil isolates were resistant to carbenicillin. Pseudomonas aeruginosa multiplied in lettuce and bean under conditions of high temperature and high relative humidity (27 C and 80-95% relative humidity) but declined when the temperature and humidity were lowered (16 C, 55-75% relative humidity). The results suggest that soil is a reservior for P. aeruginosa and that the bacterium has the capacity to colonize plants during favorable conditions of temperature and moisture.


IgE levels in sera of patients with pemphigus or bullous pemphigoid.


Circulatory responses to bacterial cardio-stimulating substances in hemorrhagic dogs.


Studies on the cell cycle of Myxobacter AL-1. I. Size fractionation of exponentially growing cells by zonal centrifugation.


Freeze-etching of the outer membranes of Pseudomonas and Acinetobacter.


Positive reaction between australia antigen and anti-human liver antibody.


Herpesvirus--a possible cause of low fertility in male turkeys.


Serum concentration of pregnancy-specific beta-1-glycoprotein (sp-1) in normal and pathologic pregnancies.


Antibacterial action of complexing compounds. II. Influence of disodium ethylendiaminetetraacetate (NA2EDTA) on experimental infection with Pseudomonas aeruginosa in mice.


Effects of medium chain triglycerides on plasma free fatty acids in normal subjects.


Annual directory. Membership roster. Arkansas State Dental Association.


Clinical use of some dental materials composite restorative materials.


Editorial: Two threats to survival.

Editorial: Two threats to survival.


Collagen turnover in the gingiva and other mature connective tissues of the marmoset Saguinus oedipus.


Growth of Streptococcus mutans in a chemostat.


Life times: Alice Muller.

Life times: Alice Muller.


Human parotid IgA and periodontal disease.


The use of esophageal motility studies in the diagnosis of dysphagia.


Some difficulties in the treatment of dysphagia in adults.


Cidex-sterilising solution chemical.

Cidex-sterilising solution chemical.


The hippocampus and contextual retrieval of information from memory: a theory.


Mitochondrial and cytoplasmic ribosomes. Distinguishing characteristics and a requirement for the homologous ribosomal salt-extractable fraction for protein synthesis. 1. Mitochondrial and cytoplasmic ribosomes of Euglena gracilis differ in their total RNA and protein content. 2. Mitochondrial ribosomes dissociate to subunits at higher Mg(2+) concentrations than do cytoplasmic ribosomes. 3. A separable 5S RNA is obtained from cytoplasmic and chloroplast ribosomes, but not from mitochondrial ribosomes. 4. For protein-synthesizing activity with a natural mRNA, mitochondrial ribosomes use tRNA from any cell compartment and are partly active with supernatant enzymes from cytoplasm. Cytoplasmic ribosomes are partly active with enzymes and tRNA from mitochondria or chloroplasts. 5. Both mitochondrial and cytoplasmic ribosomes show high specificity for the homologous salt-extractable ribosomal fraction for protein-synthesizing activity.


Pseudoperoxidase activity of mushroom tyrosinase.


The effects of anti-arthritic gold compounds on mycoplasma and leishmania.


Anthelminthic efficacy of diospyrol and its derivatives.


Central haemodynamics during spontaneous angina pectoris.


Studies on the pathogenesis of experimental chronic active hepatitis in rabbits. II. Demonstration of immunoglobulin on isolated hepatocytes.


Parenteral nutrition.

Parenteral nutrition.


The hyperviscosity syndrome.

The hyperviscosity syndrome.


Effect of ferrous ions on microsomal phospholipid peroxidation and related light emission.


Partial specific volume and molecular weight determinations from sedimentation equilibrium experiments in H2O and H2-18O. Study of an immunomacroglobulin type lambda, (IgM) Lambda.


Supplementary feeding during the preweaning period. Effect on carcass composition and adipose tissue cellularity of the rat.


Evolution of titre of serum IgG in newborn.


Proceedings: Effect of cromoglycate and eicosatetraynoic acid on the release of prostaglandins and SRS-a from immunologically challenged guinea pig lungs.


Effects of dipyridamole on neurogenic and non-neurogenic dilator responses of arterial smooth muscle. 1 In the isolated, perfused parametrial artery of the guinea-pig dipyridamole (10-100 ng/ml) potentiated dilator responses to adenosine 5'-triphosphate (ATP), glyceryl trinitrate and non-cholinergic, non-adrenergic inhibitory nerve stimulation to similar extents. In contrast dilator responses to acetylcholine were generally unaffected or reduced.2 These results support previous electro-physiological evidence that in this preparation cholinergic vasodilatation is mediated by a cellular mechanism different from that involved in the response to non-cholinergic dilator nervous activation.3 The results also suggest that potentiation of a neurally-mediated inhibitory response of smooth muscle by dipyridamole does not necessarily implicate ATP as the transmitter involved in this response.


Experience with treatment of primary malignant disease of the prostate by localised external supervoltage irradiation using cobalt-60 or high energy electrons.


Serological investigations on endotoxins isolated from Sphaerophorus funduliformis (syn. Fusobacterium necrophorum) strains.


Comparative immunochemical studies on the endotoxins of two Fusobacterium necrophorum strains.


Chemistry of the renal reabsorption of bicarbonate.


Turnover and metabolism of polychlorinated biphenyls in relation to their chemical structure and the movement of lipids in the pigeon.


A differential effect of IgM and IgG antibodies on the blastogenic response of lymphocytes to rubella virus.


Studies on antigenic competition.  Efforts to identify the cellular basis of competition using a cell transfer system.


Surface immunoglobulin of mouse thymus cells and its in vitro biosynthesis.


Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice.


Studies on kallikreins. III. Intra-intestinal administration of hog pancreatic kallikrein and its appearance in the perfusate from the mesenteric vein.


The chemistry and control of hereditary lipid diseases.


The properties of alpha-galactosidase remaining in kidney and liver of patients with Fabry's disease.


Diseases of the hypothalamus and pituitary gland.


Evidence for the activation of complement via the alternate pathway in skin diseases. II. Dermatitis herpetiformis.


A human monoclonal IgM with binding activity for C-reactive protein (CRP).


The interaction of lupus-inducing drugs with deoxyribonucleic acid.


A review: The obese strain (OS) of chickens: an animal model with spontaneous autoimmune thyroiditis.


Larval-specific serum protein in the order Dictyoptera I. Immunologic characterization in larval Blattella germanica and cross-reaction throughout the order.


Chemical composition of the cuticle, and the inner and outer shell membranes from eggs of Gallus gallus.


Predicting the stabilities of freeze-dried suspensions of Lactobacillus acidophilus by the accelerated storage test.


Disorders of the autonomic nervous system.  Chapter 14.  The alimentary tract.


Cryosurgery of the rabbit prostate. Comparison of the immune response of immature and mature bucks.


The effect of abrupt changes in sodium chloride concentration upon the viability of gram-negative bacteria at 2 and 40 degrees C.


Child abuse: one tree in the forest.

Child abuse: one tree in the forest.


Epilepsy due to cerebral cysticercosis.

Epilepsy due to cerebral cysticercosis.


Childhood epileptic encephalopathy with slow spike-wave. A statistical study of 80 cases.


Pharmacoligic prophylaxis of posttraumatic epilepsy. A review.


Epilepsy with multiple sclerosis.

Epilepsy with multiple sclerosis.


Proceedings: Responsiveness at the onset of spike-wave bursts.


Proceedings: A multifactorial analysis of focal and generalized cortico-reticular (centrencephalic) epilepsy.


Proceedings: Focal spikes in childhood and the concept of "functional" spike activity.


Proceedings: Long-term follow-up of children with grand mal seizures.


Interaction between beta-lactam antibiotics and exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.


The effect of beta-ecdysone on protein synthesis in imaginal discs of Drosophila melanogaster cultured in vitro.


The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases.


Leucine tolerance in protein-calorie malnutrition.


Nasogastric tube feeding.

Nasogastric tube feeding.


Lactose absorption in protein-calorie malnutrition.


The glycogenolytic activity in protein-calorie malnutrition.


Classification and epidemiology of protein-calorie malnutrition.


Dietary faults in health and disease leading to protein-calorie malnutrition.


Parenteral feeding.

Parenteral feeding.


Treatment of protein--calorie malnutrition using a protein rich food (AN-68) based on "Bellila dish".


Positive selection for mating with functional heterokaryons in Tetrahymena pyriformis. Allelic assortment of Tetrahymena pyriformis makes possible the isolation of cells which contain both a heterozygous germ line nucleus and a somatic nucleus which expresses phenotypes of only one member of allelic pairs. Cycloheximide-sensitive segregants have been isolated from the vegetative progeny of cells heterozygous for a dominant mutation conferring resistance to cycloheximide; such segregants are called functional heterokaryons. Since progeny from crosses of these cells are cycloheximide-resistant, addition of the drug provides positive selection for successful exconjugants. The timing for expression of the new phenotype during conjugation is presented and used to identify what appear to be immature progeny of round one mating in genomic exclusion. Usefulness of functional heterokaryons in a number of genetic and developmental studies is discussed.


Histologic identification and immunochemical studies of prolactin and growth hormone in the primate pituitary gland.


Genetic limits of the xanthine dehydrogenase structural element within the rosy locus in Drosophila melanogaster. Experiments are described that provide an opportunity to estimate the genetic limits of the structural (amino acid coding) portion of the rosy locus (3:52.0) in Drosophila melanogaster, which controls the enzyme, xanthine dehydrogenase (XDH). This is accomplished by mapping experiments which localize sites responsible for electrophoretic variation in the enzyme on the known genetic map of null-XDH rosy mutants. Electrophoretic sites are distributed along a large portion of the null mutant map. A cis-trans test involving electrophoretic variants in the left- and right-hand portions of the map leads to the conclusion that the entire region between these variants is also structural. Hence most, if not all, of the null mutant map of the rosy locus contains structural information for the amino acid sequence of the XDH polypeptide. Consideration is given to the significance of the present results for the general problem of gene organization in higher eukaryotes.


Ribosomal gene magnification in Drosophila: a chromosomal change. The sex-linked mutant "bobbed" can undergo a rapid phenotypic reversion during a prescribed series of outcrosses. The experiments reported here distinguish between two general genetic models. The first is that the phenotypic change results from the changing genetic background brought about by the outcrosses. The second is that the phenotypic change results from an alteration of the X chromosome in the germ line. The data support the second model. It is shown that both the bobbed and reverted phenotypes segregate from the same female. In addition, the reverted phenotype maps in or near the proximal heterochromatin of the X chromosome, which is the standard map position of both bobbed and the nucleolus organizer.


The direction of linkage disequilibrium. The previous paper (Langley, Tobari and Kojima 1974) reports that the directional linkage disequilibria, D(omega) = P(AB)P(ab)-P(Ab)P(aB), tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in this direction is produced at equilibrium when double homozygotes have fitnesses that are a constant fraction of the product of the two component single homozygote fitnesses, a pattern that is frequently observed in experimental data.


Linkage disequilibrium in natural populations of Drosophila melanogaster. Two large, stable populations (Texas and Japan) of Drosophila melanogaster were surveyed at 21 allozyme loci on the second and third chromosomes and for chromosomal gene arrangements on those two chromosomes. Over 220 independent gametes were sampled from each population. The types and frequencies of the surveyed genetic variation are similar to those observed previously and suggest only slight differentiation among geographically distant populations. Linkage disequilibrium among linked allozymes loci is only slightly, if at all, detectable with these sample sizes. Linkage disequilibrium between linked inversions and allozymes loci is common especially when located in the same arm. These disequilibria appear to be in the same direction for most comparisons in the two population samples. This result is interpreted as evidence of similar selective environments (ecological and genetic) in the two populations. It is also noted that the direction of these linkage disequilibria appears to be oriented with respect to the gene frequencies at the component loci.


Population structure in artificial selection: studies with Drosophila melanogaster.


Genetic analysis of larval feeding behaviour in Drosophila melanogaster.


Physiological genetics of melantoic tumours in Drosophila melanogaster. VIII. The role of choline in the expression of the tumor gene tu bw and of its suppressor, su-tu.


The mode of attachment and relation to the host in Apiosoma piscicola Blanchard and Epistylis lwoffi Fauré-Fremiet, ectocommensals of freshwater fish.


Thyrotropin responses to TRH in depressive illness: relation to clinical subtypes and prolonged duration of depressive episode.


Investigations on the antilipolytic activity of sulfonylureas in man with indications on limit dosages concerning their insulin-secreting properties.


Impaired prolactin response to synthetic thyrotropin-releasing hormone after a 36 hour fast.


The effect of thyrotrophin-releasing hormone on serum TSH, T-4, and T-3 levels in endemic and sporadic nontoxic goitre.


Effect of the antiestrogen nafoxidine on the occurrence of estrogen-dependent renal tumors in hamster.


Thyroid hormone levels in adult protein calorie malnutrition (PCM).


Preparation of a relatively acid-stable antigen (CEA) by disruption of its specific precipitate with antibody.


Production of antibodies to carcinoembryonic antigen in tolerant rabbits.


The cardiac autoimmune system. VII. Heart specific auto-antibodies produced in rabbits immunized with human heart.


A method for assessing the in vitro chemotactic response of neutrophils utilizing 51cr-labeled human leukocytes.


Method of quick detection of antigen-antibody precipitin reaction.


Use of papain in the preparation of adult mammalian skeletal muscle for tissue culture.


Anti-SRBC plaque-forming cells in liver, spleen and hepatocyte cell suspensions of rabbits and mice.


The influence of the shape of phagocytes on their adhesiveness.


Inhibition of rosette formation by spleen cells of immunized mice by antibodies to aggregated mouse immunoglobulins.


Characterization of subunits from a reconstituted monoclonal IgM that binds IgG.


Hydrosoluble immunopotentiating substances extraced from Corynebacterium parvum.


Origin of endogenous and exogenous agents in cell cultures.


Leucocyte migration inhibition as a model for the demonstration of sensitized cells in East Coast fever.


A new method for dispersing strongly adhesive cells in tissue culture.


Non-covalent association of IgM subunits produced by reduction and alkylation.


A critical study of the IgG subclasses of Rh anti-D antibodies formed in pregnancy and in immunized volunteers.


Palyam group: a new serogroup of arboviruses: physicochemical and biological properties of Palyam and Kasba viruses.