An acquired lateral ventricular diverticulum appearing as a positive brain scan.


An acylated mannan in the membrane of Micrococcus lysodeikticus.


Allergic reactions to a horse globulin therapy and their prevention by induction of immunological tolerance.


An analysis of the efficiency of a Rhesus haemolytic disease prophylaxis programme.


An enzymological approach to the lipidoses.


An example of rapid prenatal diagnosis of Fabry's disease using microtechniques.


An immunological assay for the sigma subunit of RNA polymerase in extracts of vegetative and sporulating Bacillus subtilis. The activity of the sigma subunit of Bacillus subtilis RNA polymerase decreases markedly during the first hours of sporulation [T.G. Linn et al. (1973) Proc. Nat. Acad. Sci. USA 70, 1865-1869]. We have prepared antibody against RNA polymerase holoenzyme to determine the fate of sigma polypeptide during spore formation. This antiserum specifically and independently precipitates sigma and core polymerase from crude extracts of B. subtilis as judged by both sodium dodecyl sulfate and urea gel electrophoresis of the precipitates. We report that crude extracts of sporulating cells lacking sigma activity contain as much sigma polypeptide as extracts of vegetative cells. However, sigma polypeptide in extracts from sporulating cells is apparently only weakly associated with RNA polymerase, as indicated by the failure of sigma to co-purify efficiently with core enzyme during phase partitioning. The loss of sigma activity and the weak binding of sigma to core enzyme occurs normally in a mutant blocked at an intermediate stage of sporulation (SpoII-4Z) and in wild-type bacteria sporulating in 121B medium, Difco sporulation medium, or Sterlini-Mandelstam resuspension medium. In contrast, sigma in two mutants (SpoOa-5NA and SpoOb-6Z) blocked at an early stage of spore formation remains active and tightly associated with RNA polymerase during stationary phase.


An improved test for Haemophilus influenzae precipitins in the serum of patients with chronic respiratory disease. The detection of antibacterial precipitins in the serum of patients with chronic lower respiratory infections has been shown to be of great value in the assessment of pathogenicity of the corresponding bacterial species in the sputum. The test used hitherto, however, is time-consuming and cumbersome owing to the need to distinguish, by immunoelectrophoresis, between antibodies specific to the organism in question and those which react with antigens common to various Gram-negative species. A method has now been devised for the preparation of an extract of Haemophilus influenzae containing species-specific antigens only. Use of this extract obviates the need for immuno-electrophoresis and improves the sensitivity of the test.


An introduction to principles of veterinary clinical pharmacology: the elimination of drugs. 2. Mechanisms of drug elimination.


An aetiological study of fifty-three female patients from a subnormality hospital and of their offspring.


An investigation of the efficacy of three Brucella vaccines in cattle.


An unusual expression of Ii antigens in erythrocytes of a healthy adult person.


An overview of primary endocardial fibroelastosis and chronic viral cardiomyopathy.


An epidemiologic approach to cancer of the large intestine: the significance of disease relationships.


Anabolic and catabolic routes of arginine metabolism in B. subtilis producing bacitracin.


Analysis of albumin in meconium for early detection of cystic fibrosis. A methodological study.


Animal bite.

Animal bite.


Anaesthetic molecules.

Anaesthetic molecules.


Animal models in psychiatry.

Animal models in psychiatry.


Antagonists in the 5-phenyl-benzomorphan series.


Anti-heart antibodies in chronic cor pulmonale.


Antibody responses in cell cultures from draining and non-draining rabbit lymph nodes primed with native or polymerized human albumin.


Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurones.


Arylpyrrolidines as narcotic antagonists.


Aspects of experimental hepatocarcinogenesis. 3. Iron overload and hepatocarcinogenesis.


Assaying narcotic-antagonist drugs for analgesic activity in rhesus monkeys.


Assessment of the agonist and antagonist properties of narcotic analgesic drugs by their actions on the morphine receptor in the guinea pig ileum.


Association between histocompatibility type and the ability to make anti-Rh antibodies.


Atmospheric transport of polychlorobiphenyls to the North Atlantic.


Attempts to induce mycetoma in monkeys and mice using Madurella mycetomi.


Auditory frequency discrimination in vertebrates.


Autoimmune pulmonary fibrosis, an experimental model.


Autoradiographic examinations in the early period of wound healing.


Autoimmunity in trypanosome infections. I. Tissue autoantibodies in Trypanosoma (Trypanozoon) brucei infections of the rabbit.


Autosomal recessive cerebro-oculo-facio-skeletal (COFS) syndrome.


Axonal transport of phenylethanolamine-N-methyltransferase in toad sciatic nerve.


ABO blood groups, Rhesus negativity, and primary biliary cirrhosis. The distribution of blood groups and Rhesus negativity in 91 British patients with primary biliary cirrhosis was compared with a sample of registered blood donors. There were no significant differences from the expected proportions calculated from the control groups. Although the number of cases studied is small the analysis does not confirm previous reports of an excess of A group in the disease. If a genetic basis exists for primary biliary cirrhosis alternative markers must be found.


Australia antigen and hepatitis,.

Australia antigen and hepatitis,.


Bacillus subtilis DNA polymerases.

Bacillus subtilis DNA polymerases.


Bacterial attack on phenolic ethers. Preliminary studies on systems transporting electrons to the substrate binding components in bacterial O-dealkylases.


Bacterial calcium transport: energy-dependent calcium uptake by membrane vesicles from Bacillus megaterium. Membrane vesicles capable of energy-dependent calcium uptake have been prepared from Bacillus megaterium cells in log-phase growth or when undergoing sporulation. The uptake is dependent on the calcium concentration and appears saturable in vesicles from cells in log-phase growth. Both ascorbate and phenazine methosulfate are needed as a source of electrons for the energy-dependent increase in calcium uptake. Addition of 8 mM sodium cyanide inhibited the energy-dependent uptake. If this calcium uptake mechanism is a component of the sporulation-specific calcium accumulation process, the latter's functional expression would appear to be inhibited during log-phase growth.


Bactericidal action of a 2-hydroxy-3-alkyl-1,4-naphthoquinone: blockade of metabolite permeation across the membrane.


Bile production in fasted and fed primates. Previous experiments have suggested differences in the bile salt independent flow rate between monkeys and dogs, and in the ability of bile salt secretion to influence bile flow. The present study was performed to determine whether the availability of food could have influenced these results. Bile flow and bile salt secretion rates were studied in fasted and fed primates. In the fasting experiments, sodium cholate, sodium taurocholate, and monkey bile were infused into the duodenum; only sodium cholate was infused in the feeding experiments. The results showed that bile flow was linearly related to the bile salt secretion rate in both fasting and feeding animals. Bile salt independent flow is extremely variable during fasting and is increased and stabilized by feeding. These studies indicate that the differences found in previous experiments are probably attributable to variations in experimental design.


Binding of radioactive chinoform to cohn fractions of human serum by equilibrium dialysis.


Bioavailability of indomethacin in man.

Bioavailability of indomethacin in man.


Biochemical studies on degenerative neurological disorders. I. Acute experimental encephalitis.


Biochemistry of drug dependence.

Biochemistry of drug dependence.


Biochemistry of mammalian fertilization.


Biochemistry of penicillin and cephalosporin fermentations.


Blood grouping with a miniature Centrifugal Fast Analyzer.


Blood lymphocytes after radiation therapy of mammary carcinoma.


Brain stem unit activity related to horizontal eye movements occurring during visual tracking.


Brain to bottle time.

Brain to bottle time.


Breakdown of pulse-labeled ribonucleic acid and polysomes in Bacillus megaterium: actions of streptolydigin, echinomycin, and triostins.


Brucellosis of the carpus. Report of a case.


Bridged amino tetralins.

Bridged amino tetralins.


Bursal and postbursal cells in chicken. Separation by gradient centrifugation.


Carbonic anhydrases from human neonatal erythrocytes.


Carcinogenicity of bracken and shikimic acid.


Carcinoma of the larynx in two patients with keratoacanthoma.


Cardiohemodynamic effect of 5-methyl-7-diethyl-amino-s-triazolo-(1,5a)pyrimidine (trapymin).


Care-eliciting behavior in man.

Care-eliciting behavior in man.


Cardiovascular and hematological parameters affected by feeding various polychlorinated biphenyls to the single comb white leghorn cockerel.


Carnosinase: its presence in Pseudomonas aeruginosa.


Carrier protein of iodochloroxyquinoline in the serum.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 35-1974.


Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells.


Cell-mediated cytotoxicity against ectromelia virus-infected target cells. I. Specificity and kinetics.


Cellular sites of immunoglobulins. V. An immunological study of the human gall bladder.


Cephacetrile, a new cephalosporin, in the treatment of urinary tract infections.


Changes in serum alpha-amylase activity in pigs induced by ethionine intoxication.


Characterization of a calcium-binding IgG myeloma protein.


Characterization of several viruses isolated from chickens with inclusion body hepatitis and aplastic anemia.


Characterization of persistent Modoc viral infections in Syrian hamsters. Adult Syrian hamsters were readily infected by intranasal inoculation with Modoc virus. Viremias were detected 2 to 6 days after infection and peak viremia titers (10(6.2) plaque-forming units/ml of blood) occurred 4 days postinoculation. All infected animals developed neutralizing and hemagglutination-inhibiting antibodies by 7 days, and complement-fixing antibodies by 14 days postinoculation. High titers of antibodies persisted for at least 4 months. Modoc virus was recovered from throat swabs at 7 days postinoculation, but not at 14 days or later. Urine samples were positive for virus throughout a 12-week observation period. Isolation of virus from lungs and kidneys of one and three animals, respectively, at 151 to 221 days after inoculation confirmed chronic infection. Viral isolations were made only when organs were cultivated in vitro and were unsuccessful by tests on 10% homogenates of the organs. Horizontal viral transmission of virus by infected hamsters that were viruric was demonstrated in only 1 of 27 normal hamsters that were cocaged for 4 weeks under crowded conditions. General failure to obtain horizontal viral transmission may relate to rapid inactivation of virus in excreted urine. Vertical viral transmission was not demonstrated from five chronically infected female hamsters to their 34 offspring. However, if primary infection occurred during pregnancy, the progeny were either stillborn or died shortly after birth, and thus appeared to represent transplacental viral transmission.


Characteristics of PRD1, a plasmid-dependent broad host range DNA bacteriophage. Several distinctive properties of PRD1, an icosahedral plasmid-dependent phage, are described. The drug-resistance plasmid-dependent host range of PRD1 extends beyond the P incompatibility group and includes gram-negative bacteria containing plasmids of incompatibility groups N and W. PRD1 phage will infect pseudomonads and Enterobacteriaceae containing either a P or W incompatibility group plasmid. PRD1 adsorbs to the cell wall of R(+) bacteria and thus its infectivity indicates cell wall alterations by these drug-resistance plasmid groups. PRD1 nucleic acid is duplex DNA with an estimated molecular weight of 24 x 10(6). The appearance of PRD1 in electron micrographs is suggestive of lipid content in addition to its buoyant density of 1.348 in CsCl and its sensitivity to chloroform. The latent period of PRD1 varies with the R(+) host bacterial strain used for growth of the phage.


Characterization of the "pregnancy zone protein" in relation to other alpha 2-globulins of pregnancy.


Characterization of two melanins produced by Phialophora verrucosa.


Chimeric Drosophila adults produced by transplantation of nuclei into specific regions of fertilized eggs.


Characterization of the active transport of chlorotetracycline in staphylococcus aureus by a fluorescence technique.


Chitinase in goat serum. Preliminary purification and characterization.


Chlorhexidine resistance in Proteus mirabilis. A total of 104 clinical isolates of Pr. mirabilis from three hospitals were screened for their sensitivity to chlorhexidine. The minimum inhibitory concentrations of the antiseptic for these strains ranged from 10 to 800 mug/ml. Two strains sensitive to 20 mug of chlorhexidine/ml were adapted to resistance by growth in subinhibitory concentrations of the antiseptic, their MIC values increasing to 200 and 800 mug/ml. These derived strains exhibited slightly reduced sensitivity to cetrimide and benzalkonium chloride. The chlorhexidine-resistant clinical isolates also exhibited this partially decreased sensitivity to the quaternary ammonium compounds. Both the chlorhexidine-sensitive and -resistant strains were uniformly sensitive to chloroxylenol (Dettol), glutaraldehyde, and 2-phenoxyethanol.


Chorismate mutase from Streptomyces. Purification, properties, and subunit structure of the enzyme from Streptomyces aureofaciens Tü 24.


Choice among penicillins and cephalosporins.


Citrate metabolism in Aerobacter cloacae. Growth of Aerobacter cloacae on citrate either anaerobically or aerobically did not require and was not stimulated by the presence of Na(+) in the medium. Citrate was metabolized anaerobically via the fermentation pathway as evidenced by the (i) presence of oxalacetate decarboxylase, (ii) induction of citrate lyase, and (iii) repression of alpha-ketoglutarate dehydrogenase under anaerobic conditions. Thus, although all the other enzymes of the citric acid cycle were present in anaerobic cells, this pathway was not available for the metabolism of citrate. Citrate was metabolized aerobically via the citric acid cycle, since (i) citrate lyase but not oxalacetate decarboxylase was repressed and (ii) alpha-ketoglutarate dehydrogenase was induced under these conditions. The presence of Na(+) in the medium did not lead to a repression of alpha-ketoglutarate dehydrogenase as in the case of Aerobacter aerogenes. The oxalacetate decarboxylase was a soluble, constitutive enzyme, not activated by Na(+) nor inhibited by avidin. It was slightly inhibited by ethylenediaminetetraacetate but was not stimulated by Mg(2+) or Mn(2+). Thus, this enzyme differed markedly in its properties from the same enzyme found in citrate-grown A. aerogenes.


Classical and alternate pathway activation of complement in pemphigus vulgaris lesions.


Clinical and immunologic response to bacteria isolated from tracheal secretions following tracheostomy.


Clinical experience with clonazepam (Rivotril) in the treatment of epilepsy in adults.


Cofactor investigation of bovine plasma amine oxidase. NaBH4 reduction of enzyme-substrate mixture.


Comparative anatomical studies on the mamillary body of mammals.


Comparative aspects of mammary tumors.

Comparative aspects of mammary tumors.


Comparative biochemistry of p-hydroxymethyl-L-phenylalanine: in vivo studies.


Comparison of pharmacological responses to nicotine and release of catecholamines from the adrenals in dogs and monkeys.


Computer-assisted pediatric hyperalimentation.


Concepts of louse-borne typhus control in developing countries: the use of the living attenuated E strain typhus vaccine in epidemic and endemic situations.


Concomitant decrease of the effects of thyroxin on TRH-induced TSH release, and of the pituitary content of triiodothyronine in animals on propylthiouracil.


Cone spectral sensitivity studied with an ERG method.


Conference on beta cell function, transplantation, and implantable glucose sensors: a summary.


Conformational changes of histones and DNA during the thermal denaturation of nucleoprotein.


Continuing dental education using closed circuit television.


Conformational studies of the unfolding of E. coli ribosome.


Control of gene expression in prokaryotic systems.


Continuous intravenous infusion of small doses of insulin in treatment of diabetic ketoacidosis. Continuous intravenous infusion of small amounts of insulin has been used in the management of a series of patients with diabetic ketoacidosis. In 13 patients with a plasma glucose level on admission of 725 mg/100 ml (+/- 80 S.E. of mean) and an arterial pH of 7.07 +/- 0.05 a mean loading dose of 6.5 +/- 0.82 units of soluble insulin was administered intravenously, and thereafter a sustaining infusion of 6.5 +/- 0.82 U/hr was continued until ketosis was corrected and the plasma glucose fell below 300 mg/100 ml. The total insulin dose needed to achieve this was 39.2 +/- 6.6 units given over a 3 to 10-hour period. Plasma insulin was measured in patients who had not previously received insulin and the mean level at an infusion rate of 4 U/hr was 75.6 +/- 8.0 muU/ml. Plasma glucose fell at a regular rate of 101 +/- 11 mg/100 ml/hr, and ketosis improved in parallel. Plasma potassium was well maintained throughout treatment. This regimen of treatment was clinically effective and simple to follow.


Conventional and dual competitive binding analyses of thyroxine using the Thyopac-4 kit. A simple method is described for the simultaneous determinations of thyroxine and the effective thyroxine ratio (ETR) using a single kit of Thyopac-4. Thyopac ETR values obtained were 1.00 +/- 0.03 for normal subjects; 1.22 +/- 0.11 for hyperthyroid; 0.87 +/- 0.04 for hypothyroid; and 1.02 +/- 0.05 for pregnant women. Cases with TBG deficiency and the nephrotic syndrome indicated normal values. The value (x) was correlated significantly (gamma = + 0.961) with the free Thyopac index (y), representing a regression equation of y = 71.7x(2) - 88.4x + 24.2. Thyopac ETR was shown to be useful in differentiating normal thyroid states from abnormal, irrespective of changes in T(4)-binding globulin (TBG). Further, the T(4) value obtained simultaneously made it possible to detect changes in the TBG level by noting an inconsistent value for the effective thyroxine ratio.


Correlations between pantothenate uptake, phospholipid synthesis and pantothenate-binding protein formation in Pseudomonas fluorescens P-2.


Counting the cost.

Counting the cost.


Correlations between quantitative assay of red cell-bound C3, serologic reactions, and hemolytic anemia.


Cross-linking reactions of lamprey fibrinogen and fibrin.


Current status of toxicity investigations.


Cystoid degeneration of the macula with hole formation in a baboon.


Cytogenetic effects of environmental mutagens in mammalian cells and the extrapolation to man.


Cytogenetic investigation of the Rhnull phenotype.


Deficiency of a carbonic anhydrase (CAI) isoenzyme in the chinchilla.


D-penicillamine therapy of neonatal hyperbilirubinaemia.


Degeneration of mouse pancreatic acinar cells during fasting.


Demonstration by immunodiffusion agar-gel test of Borrelia anserina antigen in the organs of infected chickens.


Demonstration of indolaminergic fibres in the media eminence of the duck, rat and monkey.


Demonstration of two kinds of thyroglobulin-related proteins bound on microsomes of hog thyroid.


Dentition of Brachyteles arachnoides with reference to Alouattine and Atelinine affinities.


Denturism--again.

Denturism--again.


Deoxyribonucleic acid polymerase 3 (Escherichia coli K12).


Detection of Australia-SH antigen in serum. A comparison of the electron microscopical, agar gel double diffusion, and complement fixation tests.


Defining the clinical problem of massive rectal bleeding.


Detection of Escherichia coli antigens by a latex agglutination test. A latex particle agglutination technique to detect ethylenediaminetetraacetate-solubilized extracts from Escherichia coli and whole E. coli cells is described. The sensitivity of the serological test was found to be 0.5 to 2.5 ng for the solubilized antigens and 1.5 x 10(6) to 5.7 x 10(6) cells per ml for the particulate antigens. The test was 100 to 1,000 times more sensitive than the standard bacterial agglutination test. Furthermore, it detected E. coli antigens during all phases of bacterial growth, whereas the bacterial test detected the antigens only after the mid-log phase. No significant cross-reactivity was observed between latex-anti-E. coli preparations and heterologous bacterial strains used in the experimental procedure. A buffer formula containing fatty acid-free bovine albumin prevented nonspecific aggregation of the latex particles.


Determination of disodium edetate dihydrate in streptomycin by atomic absorption spectrophotometry.


Detergents.

Detergents.


Determination of organ volume by means of ultrasonic B-mode scanning.


Determination of thyroid volume by ultrasonic scanning.


Development and behaviour of a strain of bovine ephemeral fever virus with unusual host range.


Detoxication of carboxin.

Detoxication of carboxin.


Development of the hypothalamohypophysial unit in the chick.


Development and evaluation of an inhalation aerosol of nitroglycerin.


Detection of antibodies to Campylobacter fetus (Vibrio fetus) in the preputial secretions of bulls with vibriosis.


Development of Sarcocystis fusiformis in the small intestine of the dog.


Diagnosis of gonorrhoea in women. Role of the rectal sample.


Diazepam prevents and aborts lidocaine convulsions in monkeys.


Differences in acute and convalescent-phase antibodies of cats infected with feline picornaviruses. Complement fixation inhibiting and complement-fixing antibodies were demonstrated in sera from cats during the acute and convalescent stages, respectively, of feline picornavirus infections. Complement-fixing antibody activity was present in 19S and 7S globulins, whereas complement fixation inhibiting antibody activity was confined to the 7S globulins. Sera with complement-fixing antibody and sera with complement fixation inhibiting antibody were also shown to have neutralizing and precipitating antibodies. In a study of antibody responses to homotypic and heterotypic strains of feline picornavirus, less serological cross-reactions were observed between strains of feline picornavirus in sera from cats in the acute phase of feline picornavirus infection than in the convalescent phase. The temporal relationship of complement fixation inhibiting and complement-fixing antibody responses of cats after acute viral respiratory infections is contrasted with previously observed antibody response in cats to feline leukemia virus.


Differentiation and characterization of isomeric polychlorinated biphenyls by gas-liquid chromatography coupled with electron impact and chemical ionization mass spectrometry.


Diphtheria.

Diphtheria.


Diseases of the oral mucosa.

Diseases of the oral mucosa.


Disruption of social behaviour of vervet monkeys (Cercopithecus) by low doses of amphetamines.


Discussion paper: antibiotic-sensitive mutants of Escherichia coli possess altered outer membranes.


Disseminated mastocytoma and mastocytemia in a dog.


Distribution and concentration of TRH in the rat brain.


Distribution of lipase in the digestive system of two teleost fishes.


Distribution of pentazocine in blood and brain of the baboon following intravenous injection. 1 In the baboon the blood levels of pentazocine between 1 and 60 min after intravenous injection of 0.5 mg/kg were measured by a gas chromatographic technique. From cerebral arteriovenous differences it was shown that the peak of the brain concentration occurred within 15 min and probably within 10 min of intravenous injection. At the time of peak concentration about 10% of the injected dose was in the brain, while the corresponding value at 60 min was 2%.2 The concentration of pentazocine in the brain was an order of magnitude greater than the concentration in cerebral venous blood both at 5 min and 60 min after injection. No major brain interregional differences were demonstrated. Cerebrospinal fluid from the cisterna magna did not yield values from which the cerebral concentration of pentazocine could be predicted.


Dose distributions modified by narrow field scanning method in high-energy electron-beam therapy.


Dithiothreitol-dependent antilisterial activity of lysates from normal macrophages exposed in vitro to culture fluids from spleen cells of BCG-immunized mice. The effect of culture fluids from mouse lymphocytes on the antilisterial activity of normal macrophages in vitro was determined. Titers of lysates of macrophages incubated with or without culture fluids from lymphocytes from control mice had titers of 10 to 270 with or without a reducing agent, dithiothreitol. Lysates of macrophages after incubation with culture fluids of spleen lymphocytes from BCG-immunized mice had antilisterial titers with and without dithiothreitol of 197,000 and 810, respectively. This may indicate a dithiothreitol-dependent antilisterial system inherent in activated macrophages of cell-mediated immunity. Lysates of incubated spleen cells and their culture fluids also had slight antilisterial activity.


Double gel diffusion studies on Pseudomonas aeruginosa O antigens.


Duodenal perforation: a complication of neonatal nasojejunal feeding.


Dynamic aspects of the interaction between antibodies and complement at the cell surface.


Dynamics of glomerular ultrafiltration. VI. Studies in the primate.


Early protein-calorie malnutrition in slum areas of Bangkok Municipality, 1970-71.


Ecdysone levels during metamorphosis of Drosophila melanogaster.


Echographic evaluation of abdominal tumor regression during antineoplastic treatment.


Editorial: Open system in name only?

Editorial: Open system in name only?


Editorial: Ischemia and the gastric mucosal barrier: a note of caution.


Editorial: Primary care defined; Educational development needed.


Editorial: Optimism in the control of atherosclerosis.


Editorial: Prostheses for the blind.

Editorial: Prostheses for the blind.


Editorial: The hypothalamic hypophysiotropic thyrotropin releasing hormone (TRH).


Dynamics and control mechanisms in maintenance of regional cerebral blood flow.


Effect of aflatoxin on serum proteins, complement activity, and the antibody response to Brucella abortus in guinea pigs.


Effect of boric acid on the catalytic activity of Streptomyces griseus protease 3.


Effect of chrysene and carbon tetrachloride administration on rat hepatic microsomal monooxygenase and UDPglucuronosyltransferase activity.


Effect of dextranase on plaque formation in Macaca mulata.


Effect of dietary energy vs. protein restriction on blood constituents and reproductive performance in swine.


Effect of exercise on platelet count, adhesion, and aggregation.


Effect of estrogens at high dosage on the human endometrium.


Effect of fentanyl on pendular rotation nystagmus in squirrel monkeys.


Effect of ischemia on hepatic parenchymal and reticuloendothelial function in the baboon.


Effect of pH on potential difference and short circuit current in the isolated human cornea.


Effect of ouabain on sodium transport across hormone-stimulated toad bladder and skin.


Effect of pH on the catalytic activity of Streptomyces griseus protease 3.


Effect of spermidine on morphogenesis in Myxococcus fulvus.


Effect of the herbicide N-phosphonomethylglycine on the biosynthesis of aromatic amino acids.


Effective treatment of gonorrhoea in London with two oral doses of amoxycillin.


Effects of anesthetics on cerebral, renal, and splanchnic circulations: recent developments.


Effects of carbaryl on mouse organs of reproduction.


Effects of chemically pure chlorobiphenyls on the morphology of rat liver.


Effects of diphenylamine on sodium and water transport across the toad skin and bladder.


Effects of glucocorticoids on TRH and TSH secretion: dose and time considerations.


Effects of high-dose medroxyprogesterone given for endometrial carcinoma on serum proteins. 29 women with endometrial cancer were treated with 50-mg medroxyprogesterone twice daily for 1 year and studied to determine what effect this dose of progesterone had on serum proteins.  Total serum proteins were significantly (p less than .01) elevated at 3 months until 6 months after treatment.  There was a transient decline in albumin at 1 month (p less than .01) which reelevated after 3 months.  Alpha-1-globulin and alpha-2-globulin increased at the beginning of therapy (p less than .001 at 1 month) and returned to pretreatment levels at the end of therapy.  Gamma globulin levels were significantly less after 1 year of therapy.  Alpha-1-acid-glycoprotein was significantly elevated at 1 month and returned to normal after therapy ended.  These protein levels are compared with those in pregnancy and during oral contraceptive therapy.  It is concluded that these changes are smaller and even the reverse of those seen in pregnancy and oral contraceptive therapy; the changes are attributed to the effect of sex hormones on hepatic metabolic activities.


Effects of listerial hemolysin on perfused isolated rat hearts.


Effects of hypophysectomy of liver donor on net synthesis of specific plasma proteins by the isolated perfused rat liver. Modulation of synthesis of albumin, fibrinogen, alpha 1-acid glycoprotein, alpha 2-(acute phase)-globulin, and haptoglobin by insulin, cortisol, triiodothyronine, and growth hormone.


Effects of stress on the results of glucose tolerance tests performed on vervet monkeys (Cercopithecus pygerythrus F. Cuvier).


Effects of CI 744 on skeletal muscle activity in monkeys (Macaca mulatta).


Electron microscopic observations of Pseudomonas aeruginosa.


Elevated alpha1-Antitrypsin serum levels in lung cancer patients.


Embryonic defects in Drosophila eggs after partial u.v. irradiation at different wavelengths.


Embryonic pole cells and mycoplasmalike symbionts in Drosophila paulistorum.


Embryotoxic and teratogenic effect of actinomycin D in the Syrian hamster.


Employing mentally retarded ex-residents in the institution.


Endoscopic removal of a knotted feeding tube from an infant.


Endosymbionts: factors on egg pattern formation.


Enhancement of hepatic microsomal drug oxidation and glucuronidation in rat by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).


Enterocutaneous fistula. The "new look".


Enhancement of tumour growth by lymphoid cells from mice treated with antilymphocyte globulin.


Enzymatic characterization of sucrose-gradient microbodies of dark-grown, greening and continuously light-grown Euglena gracilis.


Enzyme activity of spermatozoa from the ductus deferens of inbred mice.


Epidemiology of large bowel disease: the role of fibre.


Estimation of the number and size of ribosomal proteins by two-dimensional gel electrophoresis.


Estimation of chronic dopamine release from the caudate nucleus of the Macaca mulatta.


Evaluation in nonhuman primates: evaluation of the physical dependence capacities of oripavine-thebaine partial agonists in patas monkeys.


Evaluation of effects of cytosine arabinoside on Herpesvirus saimiri replication in owl monkey kidney cells.


Experimental anesthetization of a dromedary camel.


Experimental alterations of prolactin levels in goat milk and blood plasma.


Evidence for an unusual immunological response to isopentenyladenosine in rabbits.


Evaluation of topical povidone-iodine ointment in experimental burn wound sepsis.


Experimental malnutrition of neurons and glial cells in vitro. II. Activation of lysosomes and cell death.


Experimental malnutrition of neurons and glial cells in vitro. I. First stages of degeneration.


Experimental studies on the nucleus cervicalis lateralis (NCL) of Macaca cyclopis (Swinhoe). II. The spinal afferents to the nucleus cervicalis lateralis in the monkey.


Experimental hepatic porphyria induced by polychlorinated biphenyls.


Experimentally induced aberrations in the pattern of differentiation in the cellular slime mould Dictyostelium discoideum.


Experimental listeria monocytogenes-lymphadenitis. Pathohistological observations.


Extracellular space in some isolated tissues. 1. The spaces occupied by isotopically labelled inulin, polyethylene glycol, mol. wt. 4000 (PEG 4000), polyethylene glycol, mol. wt. 1000 (PEG 1000) and sucrose in metabolizing mammalian kidney and liver slices and in toad bladder epithelial cell preparations incubated in vitro have been examined.2. In slices of mammalian tissue, and in homogenized liver, it proved impossible to extract inulin completely from tissue which had been dried. However, inulin was recovered as completely from both dried and undried toad bladder epithelial cells scraped from hemibladders incubated in vitro.3. PEG 4000 occupied a space in all preparations similar to that from which inulin was extracted in dried tissue.4. PEG 1000 and sucrose entered cellular water in mammalian slices, but PEG 1000 occupied a similar space to inulin in toad bladder epithelial cell preparations.6. It is concluded that inulin enters cellular water in mammalian slices from which after drying of the slices it cannot be extracted. It thus rather fortuitously provides a measure of extracellular water under these conditions. In preparations of toad bladder epithelial cells inulin seems to be a satisfactory extracellular marker. PEG 4000, which did not appear to enter cellular water also allows a reasonable estimate of extracellular water. PEG 1000 is a suitable extracellular marker for toad bladder epithelial cell preparations but not for mammalian slices. Sucrose entered cellular water in both slices and toad bladder epithelial cells and is not a satisfactory extracellular marker in these tissues.


Extraction and purification of kanamycin inactivation enzyme of escherichia coli K12 ML1629.


EM autoradiographic studies on polytene nuclei of Drosophila melanogaster. 3. Localisation of non-replicating chromatin in the chromocentre heterochromatin.


Factors affecting the uptake of glibenclamide in microdissected pancreatic islets rich in beta-cells.


Failure of thyrotropin releasing hormone to increase 125-I uptake by the thyroid in rana temporaria.


Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. Fenfluramine, over a dose range from 0.003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital. This absence of a positive reinforcing effect could not be attributed to a slow onset of drug effect or to the use of behaviorally inactive doses. Fenfluramine, because of its distinctive properties, may produce fewer problems of human abuse than do amphetamine-type agents.


Extensive binding of concanavalin A to the nuclear membrane.


Fibrin degradation products in the serum and cerebrospinal fluid of patients with group A meningococcal meningitis. Forty-one patients suffering from group A meningococcal meningitis in an area within the epidemic meningococcal belt of tropical West Africa were studied. The serum of only two of these patients contained fibrin degradation products (FDPs). The cerebrospinal fluid of 21 of these cases was also examined for FDPs, which were present in 13. Their presence in the cerebrospinal fluid was associated with a poor prognosis.


Fibrinogen-fibrin degradation products and factor XIII.


Fibrinolysis and factor XIII.

Fibrinolysis and factor XIII.


Fibrous tumor of infancy--report of a case originating in the oral cavity.


Fine structure of the sporozoite of Schellackia occidentalis.


Experience with temporary tube gastrostomy for postoperative gastric decompression.


First clinical experience on the antiepileptic action of taurine.


Focal dermal hypoplasia.

Focal dermal hypoplasia.


Folic acid and dilantin antagonism in pregnancy.


Fracture conference: Arthrograms of the ankle. Their role in acute trauma.


Further studies on the effect of ambilhar on iron metabolism.


Further characterization of the antigens of canine prostatic fluid.


Further studies on the isotope modification of the mixed hemadsorption technique. Factors influencing the prozone effect.


Further studies on Corynebacterium species capable of producing diphtheria toxin (C. diphtheriae, C. ulcerans, C. ovis).


Galapagos iguanas: Amblyrhynchus and Conolophus serum protein relationships.


Gastric acid and plasma gastrin responses to sham feeding in duodenal ulcer patients before and after resection of antrum and duodenal bulb.


Gas chromatographic assay of iduronic and glucuronic acids as aldonic acid butaneboronates.


Gastric acid does drive pancreatic bicarbonate secretion.


Genetic and biochemical studies on cell-bound alpha-amylase in Bacillus subtilis Marburg. A small but significant amount of alpha-amylase activity was detected in the cells of Bacillus subtilis Marburg. The cell-associated activity was almost constant regardless of the level of extracellular alpha-amylase activity. The cell-bound amylase activity could be separated into three components, upon Sephadex G-75 chromatography, referred to as components A, B, and C. Component C showed the same properties as the extracellular alpha-amylases so far examined. Component A had a molecular weight greater than 70,000, as judged from the elution position on Sephadex G-75, and became smaller upon treatment with trypsin but was still larger than that of component C. An alpha-amylase mutant that lacked extracellular alpha-amylase completely because of a mutation within the structural gene of the enzyme was found to lose all three cell-bound amylase components simultaneously. These data suggest strongly that the cell-bound amylase components are precursors of the extracellular alpha-amylase and that the alpha-amylase of this organism is produced under the direction of the same gene whether the enzyme is within or outside the cell.


Genetic control of the rate of alpha-amylase synthesis in Bacillus subtilis. The level of extracellular alpha-amylase (EC 3.2.1.1) of Bacillus subtilis Marburg was increased about fivefold by introducing the amyR marker from B. natto 1212 through transformation. amyR2 of B. natto 1212 has been assumed to determine a high level of alpha-amylase of the organism. The gene acts specifically on alpha-amylase synthesis but not on the production of other extracellular enzymes. alpha-Amylase of an amyR2-carrying strain was found to be quite similar to that of an isogenic amyR1-carrying strain in the thermostability and electrophoretic behavior of whichever amylase the strain produces. Marburg-type alpha-amylase (amyEm) or B. natto-alpha-amylase (amyEn). Anti-amylase serum titration indicates that a high level of the enzyme activity in the amyR2-carrying strain is caused by the existence of more enzyme rather than the presence of an enzyme having higher efficiency. This is supported further by the fact that amyR controls the synthesis of the amyE gene product in mutant M9, which synthesizes a temperature-sensitive-alpha-amylase, and in mutant M07, which secretes cross-reacting material. The results indicate that amyR regulates the rate of alpha-amylase synthesis.


Genetic mapping in Bacillus subtilis by 5-bromouracil sensitization to ultraviolet inactivation of transforming activities. A new method for chromosome mapping of Bacillus subtilis Marburg is presented which is based on the sensitization to ultraviolet irradiation of transforming deoxyribonucleic acid that has incorporated 5-bromouracil instead of thymine. Deoxyribonucleic acid was extracted at intervals from the outgrowing spores of a thymine-requiring mutant incubated with 5-bromodeoxyuridine and subjected to a definite dose of ultraviolet irradiation. The residual activities of various genetic markers were assayed by transformation. The marker activity of deoxyribonucleic acid that had incorporated 5-bromodeoxyuridine was approximately 10 times as sensitive to ultraviolet irradiation as that of normal deoxyribonucleic acid. The markers proximal to the replication origin were sensitized at earlier times of outgrowth than distal markers. The chromosome replication in outgrowing spores was sufficiently synchronous and allowed the definite determination of when a marker became sensitized by incorporation of 5-bromodeoxyuridine. The time, designated "sensitization time," was estimated by plotting the logarithmic values of relative residual activities versus incubation times. The map constructed with sensitization times as a measurement showed good agreement with those constructed by other methods. The replication of the chromosome under the described conditions appeared to occur in the following marker order: (purA, hisA)-(purB)-(thr, pyrA)-(metC)-(leuA)-(lys, trpC, metB).


Genetical load in man.

Genetical load in man.


Gluconeogenesis in ruminants: glucose kinetic parameters in calves under standardized conditions.


Glucokinase and glucose 6-phosphate dehydrogenase in Neisseria.


Genitourinary tuberculosis: review of 102 cases. Clinical presentations, laboratory features, and responses to therapy of 102 patients treated at an army medical center for genitourinary tuberculosis between January 1961 and September 1972 are described.  During that time, a total of 3109 patients had been treated for tuberculosis of all types.  The study group included 72 men aged 18-59 with a mean age of 29, and 31 women aged 17-66, with a mean age of 31.  There was often a latent period of 20 years or more between infection with the tubercle bacillus and the expression of genitourinary tuberculosis.  The principal means of diagnosis was isolation of Mycobacterium tuberculosis from urine, obtained in 80%, or sputum, obtained in 38%.  M. tuberculosis was not cultured in 13 patients.  In patients with negative cultures, diagnosis was made by combinations of positive tuberculin skin test, caseating granulomata on biopsy, characteristic changes in the excretory urogram, characteristic bladder lesions on cystoscopy, and the presence of sterile pyuria or microscopic hematuria.  A wide variety of signs and symptoms were encountered as was a high frequency of involvement of other organ systems.  The most common laboratory abnormalities were pyuria, albuminuria, and hematuria.  75% of patients had an abnormal chest roentgenogram on admission.  88% of patients tested had positive skin tests and 63% tested had abnormal excretory urography.  16% showed renal calcification.  Only 1 nephrectomy was done in the latter 5 years of the study, for hypertension.  2 women and 6 men had hypertension, but 1 woman and 2 men had nontuberculous renal disease which could have caused the hypertension.  The evidence from the series is that infectivity of genitourinary tuberculosis is low.  There was only 1 initial treatment failure, in a 47-year old man with active pulmonary and renal tuberculosis caused by an isoniazid-resistant organism.  2 men, only 1 of whom had had genitourinary disease originally, had recurrences of tuberculous disease after prematurely discontinuing medication.


Glycogen metabolism in glycogen-rich erythrocytes.


Glycosyl transferase activity in normal and Scrapie-affected mouse brain.


Gonococcal oro- and nasopharyngeal infection.


Granulocyte transfusion therapy of experimental Pseudomonas pneumonia. Pseudomonas pneumonia was produced in dogs with radiation-induced leukopenia. Treatment of this infection with either gentamicin alone or gentamicin plus daily granulocyte transfusion was compared in a randomized controlled trail. The dogs receiving granulocytes plus gentamicin survived significantly longer than those treated with gentamicin alone (P < 0.05). The Pseudomonas immunotype which was inoculated into the dogs were recovered at autopsy from none of the granulocyte-transfused dogs, whereas seven or eight of the dogs treated with gentamicin alone had the inoculated Pseudomonas immunotype in the area of induced pneumonia at autopsy. As measured by the limulus test, the granulocyte-transfused dogs also did not have endotoxemia as frequently as the dogs given only gentamicin (P < 0.05). This controlled study establishes that transfused granulocytes can favorably alter the course of experimental Pseudomonas pneumonia and suggests that granulocyte transfusion may be a useful therapy in serious bacterial infections of leukopenic subjects.


Granulomatous reaction in experimental stapedectomy.


Growth of the Bacillus subtilis cell surface. A double mutant strain, Bacillus subtilis div IV B1 dal trp, has been constructed which grows as filamentous cells and minicells and requires d-alanine for growth. Removal of d-alanine from a growing population of cells resulted in cell bulging 25% of the cell length from one cell pole, followed by cell lysis. Little ultrastructural change in the cell envelope could be detected during bulge formation.


GLC determination of fluorouracil.

GLC determination of fluorouracil.


GP-350, a sialoglycoprotein from calf brain: its subcellular localization and occurrence in various brain areas.


Haemoglobin inkster (alpha2 85aspartic acid leads to valine beta2) coexisting with beta-thalassaemia in a Caucasian family.


Haemoglobin Madrid beta 115 (G17) alanine--proline: an unstable variant associated with haemolytic anaemia.


Haemolytic disease of new-born due to anti-D antibodies in a Du-positive mother.


Gonococcal pharyngitis. A report of four cases and a review of the literature.


Hematologic malignancies and other marrow failure states: progress in the management of complicating infections.


Haemostatic defects in myelofibrosis.

Haemostatic defects in myelofibrosis.


Heterogeneity of monoclonal immunoglobulin-G proteins studied by isoelectric focusing.


Heterotrophic growth of the nitrogen fixing blue-green alga Nostoc muscorum.


Histamine content of hypothalamic nuclei of the rat.


Histochemical evidence of a hormonal stimulation affecting the postnatal development of murine Paneth cells.


Homocystinemia. Vascular injury and arterial thrombosis.


Homologies in procaryotic ribosomal proteins: alanine rich acidic proteins associated with polypeptide translocation.


Homology of amino-terminal regions of C-phycocyanins from a prokaryote and a eukaryote.


Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus. Description of a cytoplasmic nonribosomal antigen.


Hydrophobic grid-membrane filters: new approach to microbiological enumeration. A square grid pattern, printed in hydrophobic material on conventional membrane filters, subdivided the surface into a plurality of areas. This separated colonies from one another and prevented lateral growth, spreading, and confluence. Very high colony-packing densities were achieved (2,500/in(2); ca. 1.61 x 10(5)/cm(2)) reducing the need to dilute samples. Recovery of organisms was better than on conventional filters, particularly at high inoculum levels. At the same time, visibility of normally pale or diffuse colonies was improved, since colonies grew upwards instead of sideways, and counting was facilitated because colonies grew in orderly arrays.


Hybridization studies with RNA and DNA isolated from Euglena gracilis chloroplasts and mitochondria.


Identification of cone mechanisms in graded responses of foveal striate cortex. 1. The earliest electrical response detectable in foveal striate cortex of anaesthetized Rhesus monkeys following light stimulation is a graded potential which is positive at the cortical surface and negative in the grey matter and has a peak latency of about 60 msec. The response is similar at both the on- and the off-phase of a light stimulus.2. The relationship of this graded potential to the depth of the recording electrode, to the latency of extracellular impulses and to post-synaptic potentials suggests that it is generated by the depolarization of cortical cells.3. Action spectra obtained in the presence of strong selective chromatic adaptation indicate the participation of all three cone mechanisms in this response.4. Each cone mechanism contributes a similar potential to the response but antagonism between cone mechanisms is apparent. The proportion in which a cone mechanism contributes to the response varies from one area to another implying topographical differences in the representation of cone mechanisms in striate cortex.


Hypothalamic catecholamines and adrenergic innervation of hypothalamic blood vessels. Potential role in shock.


Identification of primate hair.

Identification of primate hair.


Identification of group B streptococci by immunofluorescence staining. Gamma globulin fractions of rabbit antisera prepared with whole cell vaccines of group B types Ia, Ib, II, and III and labeled with fluorescein isothiocyanate stained group B streptococci type specifically. Type Ic cells, which contain the Ia polysaccharide antigen of type Ia and the Ic protein antigen of type Ib, were specifically stained by both Ia and Ib conjugates. A group B conjugate pool (B pool) that contained one conjugate specific for each group B type at its predetermined titer gave positive fluorescent-antibody (FA) reactions (4+ intensity) with group B stock strains and negative FA reactions (less than 2+ intensity) with stock strains of streptococcal groups A, C through H, and K through U, viridans streptococci, Streptococcus pneumoniae, Staphylococcus aureus, Neisseria gonorrhoeae, and representative Enterobacteriaceae. Examination of 883 clinical isolates submitted to the Streptococcus Laboratory (Center for Disease Control, Atlanta, Ga.) for identification revealed a 99.1% agreement between FA and culture-precipitin methods. All 305 group B streptococci identified by culture-precipitin and six nonhemolytic group B streptococci missed initially by culture tests were identified correctly by FA. Results of cultural and FA methods in a double-blind study of 99 vaginal swabs agreed on 96 of 99 strains. Three nonhemolytic group B streptococci were identified first by FA and later confirmed by culture-precipitin tests.


IgG hydrolysis in abscesses. I. A study of the IgG in human abscess fluid.


Immune reactions of the syngeneic host after the intradermal injection of tumor cells and microsomes.


Immunity and malaria in man.

Immunity and malaria in man.


Immunodiffusion studies on sera from animals infected with Schistosoma japonicum.


Immunoassay using antibody--enzyme conjugates.


Immunofluorescence test for persistent poxvirus antibodies.


Immunoglobulin D (IgD) in childhood. II. Serum IgD levels in juvenile rheumatoid arthritis.


Hyperalimentation as preparation for surgery in transmural colitis (Crohn's disease).


Immunoglobulins G and M in newborn cord serum.


Impaired platelet function in glucose-6-phosphatase deficiency.


Immunological studies of brain specific protein.


Improved method of nasojejunal feeding in low-birth-weight infants.


In vitro hydrolysis of prostaglandin F2alpha, esters by serum or plasma of different animal species.


In vitro restoration of deficient beta-galactosidase activity in liver of patients with Hurler and Hunter disease.


In vitro metabolism of testosterone in seminal vesicles of rats.


In vivo studies on the uptake and binding of beta-lactam antibiotics in relation to inhibition of wall synthesis and cell death.


Incidence of antiprotozoal and antivermal antibiotics in fungi. IV. Fungi imperfecti, order Moniliales, collected in China.


Increase of fungitoxicity of mercuric chloride by methionine, ethionine and S-methylcysteine.


Increased diamine oxidase activity in the intestinal lymph of rats on fat ingestion.


Increased elevation of peripheral leukocyte counts by infusion of histocompatible granulocytes.


Induction of chronic growth hormone deficiency by anti-GH serum.


Independence of iron absorption from the rate of erythropoiesis.


Infantile obesity and later weight control in the baboon.


Influence of acids and salts on the efficiency of the dialyser in the automated analysis of sialic acid.


Influence of dietary factors on the gastrointestinal absorption of lead.


Inhibition of intestinal absorption of folic acid by phenytoin.


Inhibition of the oxytocic action of prostaglandin F2alpha on pregnant rabbit uterus by intra-aortic infusion of theophylline in vivo.


Inhibition of antibody formation during continual stimulation with a strong immunogen.


Inhibition of Streptomyces griseus protease B by peptide chloromethyl ketones: partial mapping of the binding site and identification of the reactive residue.


Inputs into coronary care during 30 years. A cost effectiveness study.


Initiation of spore germination in Bacillus subtilis: relationship to inhibition of L-alanine metabolism. The inhibitory effects of anthranilic acid esters (methyl anthranilate and N-methyl anthranilate) on the l-alanine-induced initiation of spore germination was examined in Bacillus subtilis 168. Methyl anthranilate irreversibly inhibited alanine initiation by a competitive mechanism. In its presence, the inhibition could be reversed only by the combined addition of d-glucose, d-fructose, and K(+). Both l-alanine dehydrogenase and l-glutamate-pyruvate transaminase, enzymes which catalyze the first reaction in l-alanine metabolism, were competitively inhibited by methyl anthranilate. The K(i) values for germination initiation (0.053 mM) and of l-glutamate-pyruvate transaminase (0.068 mM) were similar, whereas that for l-alanine dehydrogenase (0.4 mM) was six to seven times higher. Since a mutant lacking l-alanine dehydrogenase activity germinated normally in l-alanine alone, it is speculated that the major pathway of l-alanine metabolism during initiation may be via transmination reaction.


Instrumental detection system based on light scattering for performing assays in which agglutination reactions are used.


Insensitivity of homocitrate synthase in extracts of Penicillium chyrosogenum to feedback inhibition by lysine. We previously reported that lysine inhibits in vivo homocitrate synthesis in the lysine bradytroph, Penicillium chrysogenum L(1), and that such feedback inhibition could explain the known lysine inhibition of penicillin formation. In the present study, it was found that dialyzed cell-free extracts of mutant L(1) converted [1-(14)C]acetate to homocitrate. This homocitrate synthase activity was extremely labile but could be stabilized by high salt concentrations. The pH optimum of the reaction was 6.9, and the K(m) was 5.5 mM with respect to alpha-ketoglutarate. The reaction was also dependent upon the presence of Mg(2+), adenosine 5'-triphosphate, and coenzyme A. Surprisingly, the activity in these crude extracts was not inhibited by lysine. Benzylpenicillin at a high concentration (20 mM) partially inhibited the enzyme, an effect that was enhanced by lysine. Casein hydrolysate also partially inhibited the enzyme.


Insulin is a Drosophila hormone and acts to enhance the differentiation of embryonic Drosophila cells.


Insulin-resistant diabetic coma. Acute onset in an unknown diabetic associated with brain-stem infarction and death.


Interaction of 125I-thyroxine with rat adenohypophyseal proteins in vitro: effect of temperature.


Interactions between exogenous deoxyribonucleic acid and membrane vesicles isolated from Bacillus subtilis 168. Membrane vesicles isolated from competent cultures of Bacillus subtilis 168 bound up to 20 mug of double-stranded deoxyribonucleic acid (DNA) per mg of membrane protein in the presence of ethylenediaminetetraacetate. The formation of the DNA-membrane complex was time, temperature, and pH dependent. Eighty per cent of the DNA could be removed from the complex by treatment with deoxyribonuclease I. Nevertheless, the DNA that remained attached to the vesicles appeared to have been attacked by the enzyme, suggesting that all the complexed DNA is located at the outer surface of the vesicles. Pretreatment of DNA with deoxyribonuclease I destroyed its affinity for the vesicles. The extent of binding decreased by the addition of Mg(2+) ions, especially at high DNA concentrations (more than 2 mug/ml). This effect was partially due to membrane-associated Mg(2+)-dependent endonucleolytic activity, which caused double-strand breaks in addition to single-strand nicks, and to exonuclease activity. The endonucleolytic activity was enhanced by heating the membranes at 80 C. DNA-membrane association was not markedly affected by sulfhydryl reagents, but was largely inhibited by formaldehyde. Endogenous competence-stimulating activity did not alter the DNA-binding capacity of the vesicles.


Interactions of narcotic antagonists with receptor sites.


Interrelationships of the fibrinolytic, coagulation, kinin generating and complement systems.


Intestinal complications of nasojejunal feeding in low-birth-weight infants.


Intestinal effects of 5-hydroxytryptamine and morphine in guinea pigs, dogs, cats and monkeys.


Intestinal disaccharidases in primary protein malnutrition in adults.


Intracellular localization of pyridoxamine-5-phosphate oxidase in rabbit liver.


Intragastric self-administration of morphine as a measure of addiction.


Investigation of the alpha-galactosidase deficiency in Fabry's disease using antibodies against the purified enzyme.


Involvement of mannosyl-phosphoryl-dolichols in mannose transfer to brain glycoproteins.


Is singlet oxygen a substrate for superoxide dismutase? No.


Is there a venoarterial difference in alpha 1-antitrypsin levels? Serum trypsin inhibitory capacity and alpha(1)-antitrypsin concentrations were compared in venous and arterial bloods obtained simultaneously from patients with chronic airways obstruction. No significant venoarterial difference was observed in most patients, which was contrary to the published findings of Woolcock et al. (1972).


Isolation and properties of a staphylococcal protease, preferentially cleaving glutamoyl-peptide bonds.


Isolation of a common cell wall antigen from the proteolytic strains of Clostridium botulinum.


Isolation of a complex of the subcomponents of the activated first component of complement, Clr--Cls, from ACD-human plasma.


Isolation of a fragment, Fh, corresponding to the hinge region of human IgG3.


Isolation of mutants defective in alpha-amylase from Bacillus subtilis: genetic analyses. The rate of alpha-amylase (EC 3.2.1.1) synthesis in Bacillus subtilis is regulated by a gene, amyR, located near a structural gene, amyE, for the enzyme. To construct a fine map of the amyR-amyE region, we isolated 28 mutants defective in alpha-amylase activity. Eleven mutants out of 28 showed no alpha-amylase activity, whereas the other 17 showed less alpha-amylase activity than the parent. Out of 17 partially positive alpha-amylase mutants, 10 produced temperature-sensitive enzymes, and 4 produced immunologically altered enzymes, two of which are concurrently temperature-sensitive, and 5 produced smaller amounts of alpha-amylases which are indistinguishable from normal enzyme in their temperature sensitivity and immunological properties. Two out of 11 alpha-amylase-negative mutants produced material that cross-reacted with anti-amylase serum, and 3 mutants carried suppressible mutations by the suppressor described by Okubo. Mapping data indicate that all 28 mutation sites are located in the amyE region, and none of the groups of the mutants mentioned above contains lesions that are clustered in a single region of amyE. The amyR gene seems most likely to adjoin the terminal region of amyE.


Isotopic labeling and analysis of phosphoproteins from mammalian ribosomes.


Kinetics of complex formation between human carbonic anhydrase B and heterocyclic sulfonamides.


Kinetic cell-cycle analysis of a cultured mammalian cell population. The parameters of the cell cycle are analyzed in terms of the stochastic theory of cell proliferation for a murine mastocytoma line. The cells were grown in suspension culture under steady-state conditions in a chemostat. Initial estimates of the parameters from synchronous growth indicate that agreement of the data with the model is obtained only if the model is modified to include an initial proliferating fraction of less than 100%, and a cell loss continuing throughout the course of the experiment. The analysis verifies that the modified theory adequately describes the data, and that similar parameters are obtained from both desynchronization and percent labeled mitosis experiments. The average cycle time from 10 desynchronization experiments was 8.24 +/- 0.52 h with a cellular standard deviation of 1.28 +/- 0.18. The combined parameter obtained by dividing the cellular standard deviation by the cycle time is shown to be a useful measure of biological variability well defined over many different experiments. The rate constant for cell loss is about 0.009 which gives an 8% cell loss per cycle. The cell loss is sufficient to account for the apparent deficit in initially proliferating cells. The initial distribution of the synchronous cells is qualitatively examined and is found to be peaked late in G(1) or early in S.


Lactoperoxidase coupled to polyacrylamide for radio-iodination of proteins to high specific activity.


Lesions produced by Echis carinatus venom in experimental animals.


Letter from the Editor.

Letter from the Editor.


Letter: A cholinesterase inhibitor produced by Aspergillus terreus.


Letter: Bacterial microflora in infants receiving nasojejunal tube feeding.


Letter: Colonial morphology of Neisseria gonorrhoeae.


Letter: Contaminated beta-lactamase and blood cultures.


Lack of effect of gold therapy on abnormal IgG and IgM metabolism in rheumatoid arthritis.


Letter: Comments on papers by Reichert and Wong.


Letter: Ear piercing.

Letter: Ear piercing.


Letter: Exercise-induced bronchospasm.

Letter: Exercise-induced bronchospasm.


Letter: Glutaraldehyde therapy for epidermolysis bullosa.


Letter: Gonorrhea.

Letter: Gonorrhea.


Letter: Immobilization of phosphotransferases obtained from resistant bacteria.


Letter: Parenteral hyperalimentation.

Letter: Parenteral hyperalimentation.


Letter: Pheochromocytoma and tricyclic antidepressants.


Letter: Structure of enzymatically acetylated sisomicin by Pseudomonas aeruginosa.


Letter: The use of nabulized Intal in asthma.


Letter: Thyroid thermogenesis.

Letter: Thyroid thermogenesis.


Library service tailored to dental needs.


Leucocyte glycogen response in inflammatory exudates.


Life-threatening Mycoplasma pneumoniae pneumonia.


Lipids of potato tubers. IV. Effect of growth and storage on the lipid-degrading enzymes of the potato tuber.


Liver iron: changes induced by cooking and acid-peptic digestion.


Localization of immunoglobulins in urinary bladder tumours.


Localization of carbonic anhydrase in avian gastric mucosa, shell gland and bone by immunohistochemistry.


Locomotor behavior of decerebellated arboreal mammals--monkey and raccoon.


Long-term care of the hemiplegic patient in the home.


Lupus erythematosus syndrome and complete deficiency of the fourth component of complement.


Lymphocyte function in breast cancer.

Lymphocyte function in breast cancer.


Lysogenic conversion to phospholipase A production in Bacillus cereus.


Lysozymes in feces from infants and children.


Maintenance of the primary symbiote of the pea aphid Acyrthosiphon pisum in liquid media.


Malnutrition and deafness.

Malnutrition and deafness.


Maternal and lateral transmission of scrapie in sheep.


Measurement of intracellular amino acids in cultured skin fibroblasts. The effect of storage on cystine recovery and evaluation of three methods of cell preparation.


Mechanism of enzyme action.

Mechanism of enzyme action.


Membrane-bound transpeptidase and penicillin binding sites in Streptomyces strain R61.


Mechanisms underlying recovery of eye-head coordination following bilateral labyrinthectomy in monkeys.


Meningococcal vaccine.

Meningococcal vaccine.


Messenger ribonucleic acid of dormant spores of Bacillus subtilis. Evidence of the presence of messenger ribonucleic acid (mRNA) in dormant spores of Bacillus subtilis has been obtained. The bulk RNA from spores was isolated and labeled in vitro with tritiated dimethyl sulfate. The spore RNA hybridized to 2.4 to 3.2% of the B. subtilis genome. The RNA hybridized to both the complementary heavy and light fractions of deoxyribonucleic acid (DNA). Bulk RNA from log-phase cells competed with virtually all the spore RNA for the heavy DNA fraction and with part of the spore RNA for the light DNA fraction. Bulk RNA from stage IV cells in sporulation also competed with all of the spore RNA for the heavy DNA fraction and with essentially all the spore RNA for the light DNA fraction. These results indicate that dormant spores contain mRNA species present in both log-phase cells and stage IV cells of sporulation. The RNA polymerase in the developing forespore must be able to recognize promotor sites for both log-phase and sporulation genes.


Metabolism of ovomucoid by the developing chick embryo.


Metabolism of trehalose in Euglena gracilis. Partial purification and some properties of phosphoglucomutase acting on beta-glucose 1-phosphate.


Metaplastic ossification of a chronically inflamed anal sac in a dog (a case report).


Methodology for the evaluation of pentazocine, prototype of the new morphine agonist-antagonist analgesics.


Microbial conversion of antibiotics. I. Deacylation of maridomycin by bacteria.


Methods in the study of isoenzymes.

Methods in the study of isoenzymes.


Microsporida of the fall webworn, Hyphantria cunea. I. Identification, distribution, and comparison of Nosema sp. with similar Nosema spp. from other Lepidoptera.


Microglioma with paraproteinaemia.

Microglioma with paraproteinaemia. A case is reported in which a solitary intracerebral tumour of lymphoreticular cells (microglioma, reticulum cell sarcoma) was associated with the presence of a serum paraprotein. Extensive investigation failed to show any evidence of extracerebral reticulosis. Response of the paraprotein to treatment of the tumour is described.


Mitigation of experimental inflammatory bowel disease in guinea pigs by selective elimination of the aerobic gram-negative intestinal microflora.


Mild familial diabetes with dominant inheritance.


Mitotic reduction in rat liver exposed to ultrasound.


Modification of hexachlorophene toxicity by dieldrin and aroclor 1254.


Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943).


Modification of the response of rats to lethal levels of ozone by enzyme-inducing agents.


Modulation of prolactin release by altered levels of thyroid hormones.


Molecular studies on glycogen storage diseases.


Mothers and therapists evaluate long-term and short-term child therapy.


Molecular weight heterogeneity of tropoelastin resulting from proteolysis during preparation.


Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases.


Multiple exposure photography for B-scans.


Multiple myeloma and macroglobulinemia. Advances in treatment.


Mutants of Bacillus subtilis bacteriophage phi e defective in dTTP-dUTP nucleotidohydrolase. Mutants of bacteriophage phie inducing only 1 to 5% of wild-type levels of dTTP-dUTP nucleotidohydrolase give normal bursts of viable progeny phage whose DNA contains 5 to 10% thymine (but no uracil) in place of 5-hydroxymethyluracil. The relative heat lability of one phage mutant enzyme solubilized from the membrane fraction of infected cells suggests that a phie gene codes for the induced dTTPase-dUTPase.


Mutational analysis of dark endogenous metabolism in the blue-green bacterium Anacystis nidulans. We describe a mutant (strain 704) of the obligate photoautotroph Anacystis nidulans which behaves like the wild type under continuous illumination but which in the dark rapidly loses viability, respires little, and incorporates label into ribonucleic acid and protein at rates considerably less than observed with the darkened wild type. Extracts of this mutant strain show no detectable 6-phosphogluconate dehydrogenase (EC 1.1.1.44) activity. Spontaneous revertants of mutant 704 were selected as survivors of prolonged incubation in darkness. Of 10 such strains examined, none had regained 6-phosphogluconate dehydrogenase activity, and all had lost detectable glucose-6-phosphate dehydrogenase (EC 1.1.1.49) activity. Although dark survival of these revertants paralleled that of the wild type, rates of dark endogenous respiration and incorporation of labeled precursors into ribonucleic acid were still very low, comparable to those observed with strain 704. These results are consistent with the following hypotheses concerning dark endogenous metabolism in unicellular blue-green bacteria. (i) Although the oxidative pentose phosphate cycle (hexose monophosphate shunt) may play a major role in endogenous metabolism in A. nidulans, as proposed by others, it is not the only pathway capable of providing energy for maintenance of viability in darkness. (ii) Much of the endogenous metabolic activity (respiration and macromolecular synthesis) observed in darkened cultures of wild-type A. nidulans is not required for survival alone, and must therefore serve other functions.


Mycobacterium kansasii in Kansas: saprophyte or infection?


N-terminal amino acid sequences of Azotobacter vinelandii and Rhodospirillum rubrum flavodoxins.


Nasojejunal feeding: a commentary.

Nasojejunal feeding: a commentary.


Narcotic antagonists of the 4-phenylpiperidine series.


National health insurance: can the U.S. learn from Canada?


Nature of the serum heat-labile accessory factor involved in the metabolic inhibition of Mycoplasma pneumoniae.


Necessity for differentiation of rhodochrous group from tubercle bacilli.


Neuro-tuberculosis, An unsolved problem.


Myocardial and systemic vascular responses to low concentration of carboxyhemoglobin.


Neurofibroma with aberrant tactile corpuscles.


Neuronal correlates of seasonal changes in contrast-detection of prey catching behaviour in toads (Bufo bufo L.).


Neurotoxicologic studies of two carbamate pesticides in subacute animal experiments.


Neutralization of allotype suppression in rabbits.


New preclinical safety evaluation for single-dose clinical pharmacology.


New phage-SPO1-induced polypeptides associated with Bacillus subtilis RNA polymerase. RNA polymerase was precipitated from extracts of Bacillus subtilis infected with phage SP01 by antiserum prepared against core RNA polymerase. As shown by sodium dodecyl sulfate gel electrophoresis, the precipitates contained at least five new polypeptides not present in uninfected bacteria, in addition to the known subunits of RNA polymerase. The molecular weights of these polypeptides are (1) 85,000; (II) 40,000; (III) 28,000; (IV) 25,000; and (V) 23,000. Four of the polypeptides (I, III, IV, and V) co-purified with RNA polymerase through gel filtration and phosphocellulose chromatography. A pulse-chase experiment indicated that all five polypeptides are synthesized de novo after infection. The synthesis of polypeptides II, III, and IV commences almost immediately after infection, while polypeptides I and V first appear several minutes later. A sus mutant blocked early in transcription, susF21 [Fujita, et al. (1971) J. Mol. Biol. 57, 301-317] failed to induce polypeptides I, IV, and V, while two other mutants, susF4 and susF14, blocked late in transcription both failed only to induce polypeptide V.


Newer antibiotic agents acting on gram-negative organisms.


Non-specific genital infection in a general practice.


Nongonococcal urethritis. A venereal disease as prevalent as epidemic gonorrhea.


Nonneurogenic disorders of the anus and rectum.


Normal factor 8 antigen level in combined congenital deficiency of factor V and factor VIII.


Normal reproductive performance of mature cockerels fed Aroclor 1248.


Nuclear segregation in Bacillus subtilis.


Nosema connori n. sp., a microsporidian parasite of man.


Observations on the ecology of Schistosoma mattheei Veglia & Le Roux, 1929, in portion of the Kruger National Park and surrounding area using a new quantitative technique for egg output.


Observations on the mechanism by which T-lymphocytes exert cytotoxic effects.


Occipital lobe epilepsy. A clinical and electroencephalographic study.


On the conformation of thyrotropin releasing hormone.


One-day oral pivampicillin hydrochloride treatment for acute gonococcal urethritis in male patients.


Opiate receptor binding: effects of enzymatic treatments.


Opponent-colour cells in different layers of foveal striate cortex. 1. The majority of cells in layer 4B have opponent-colour properties indicating that colour opponency plays an important role in the early stages of visual processing in foveal striate cortex. In contrast to cells in the lateral geniculate nucleus many of these cells receive centre-surround antagonism from the same cone mechanism. Some cells show this spatial antagonism at threshold; others require suprathreshold stimuli for its demonstration.2. The majority of cells in layer 4B do not show orientation or directional selectivity. The proportion of cells with orientation and directional selectivity increases and the proportion of opponent-colour cells decreases with increasing distance above and below layer 4B so that the majority of cells in the outer layers exhibit considerable spatial selectivity without apparent colour opponency. These changing proportions suggest that the latter cells may be receiving their inputs from different types of opponent-colour cells making them sensitive to different types of colour contrast but not to colour per se.3. More opponent-colour cells receive inputs from the red- and green- sensitive cone mechanisms than from the blue-sensitive one. This difference is more marked in layer 4B than 3B suggesting that the latter cortical layer may be more involved in colour vision than the former.


Opthalmologic effect of ultrasound at diagnostic intensities.


Oral and intravenous toxicity of delta9-tetrahydrocannabinol in rhesus monkeys.


Orbital apex syndrome complicating frontal pyocoele.


Organic mercury poisoning in children.

Organic mercury poisoning in children.


Os penis.

Os penis.


Orthophosphate requirement for the formation of phosphoenolpyruvate from pyruvate by enzyme preparations from photosynthetic bacteria. The formation of phosphoenolpyruvate from pyruvate and adenosine 5'-triphosphate by enzymes from photosynthetic bacteria required inorganic phosphate, thus indicating that these organisms utilize pyruvate, orthophosphate dikinase rather than phosphoenolpyruvate synthase in photosynthesis.


Ovarian serous neoplasms in the Rhesus monkey. Electron microscopical observations.


Ovulation block by indomethacin, an inhibitor of prostaglandin synthesis: a study of its site of action in rats.


Paraquat disposition in rats, guinea pigs and monkeys.


Partial separation on DEAE-Sephadex of antibodies reactive with plant viruses and their protein subunits.


Partial purification of proteins isolated from mammalian cornified cells.


Orbital rhabdomyosarcoma in children.

Orbital rhabdomyosarcoma in children.


Patient record systems--the making of a precedent?


Pellicle-associated structures in the amastigote stage of Trypanosoma cruzi and Leishmania species.


Penicillin and other inhibitory substances in quarter milk samples of cows at slaughter.


Penicillin and épluchage treatment of hepatic actinomycosis.


Penicillin binding components of bacterial cells and their relationship to the mechanism of penicillin action.


Penicillium endocarditis of aortic valve prosthesis.


Peripheral and cardiac factors in experimental septic shock.


Perspectives in nutrition research.

Perspectives in nutrition research.


Pharmacokinetic evaluation of anticonvulsants prior to efficacy testing exemplified by carbamazepine in epileptic monkey model.


Pharmacokinetics of Aroclor 1254 components after intravenous administration to swine and sheep.


Pharmacologic effects of MJ 9022-1, a potential tranquilizing agent.


Photo-onycholysis.

Photo-onycholysis.


Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules. Polymorphonuclear leukocytes obtained from sterile peritoneal exudates in rabbits contain two phospholipid-splitting activities (phosphatidylacylhydrolases EC 3.1.1.4), one most active at pH 5.5 and the other between pH 7.2 and 9.0. Hydrolysis of phospholipid was demonstrated using Escherichia coli labeled during growth with [1-(14)C]oleate and then autoclaved to inactivate E. coli phospholipases and to increase the accessibility of the microbial phospholipid substrates. The acid and alkaline phospholipase activities are both membrane bound, calcium dependent, and heat stable, and they appear to be specific for the 2-acyl position of phospholipids. Evidence was also obtained suggesting that the E. coli envelope phospholipids with oleate in position 2 are more readily degraded than those with palmitate. The two activities are associated with azurophilic as well as specific granules (obtained by zonal centrifugation) and with phagosomes (isolated after ingestion of paraffin particles by the granulocytes). Phospholipase A activities at pH 5.5 and pH 7.5 degrade the two major phospholipids of E. coli, phosphatidylethanolamine and phosphatidylglycerol, to the same extent, but the phospholipase activity at acid pH does not hydrolyze micellar dispersions of phosphatidylethanolamine. By contrast, phospholipase A(2) activity at pH 7.5 degrades both types of phosphatidylethanolamine substrates. Heparin and chondroitin sulfate inhibit phospholipase activity at pH 5.5 but have little effect on activity at pH 7.5. All detergents tested inhibited phospholipase activity, and both activities are inhibited by reaction products, free fatty acid and lysophosphatidylethanolamine. This product inhibition is only partially prevented by addition of albumin. Supernatant fractions of granulocyte homogenates contain a heat-labile inhibitor of granule phospholipase activity at pH 7.5. Boiling the fraction not only removes the inhibition but actually results in stimulation of hydrolysis at pH 7.5 as well as pH 5.5. These granule-associated phospholipase A activities of polymorphonuclear leukocytes differ in several of their properties from granule or lysosomal phospholipases of other phagocytic cells.


Photochemistry of bioactive compounds. Photochemical processes of polychlorinated biphenyls.


Photoreduction of dyes catalysed by organic and bio-molecules.


Physiological effect of protein deficiency with special reference to evaluation of protein nutrition and protein requirement.


Pineal structure and function in domestic livestock.


Physiological roles of pneumococcal peptidases. A methionyl-specific dipeptidase from Streptococcus pneumoniae has been described. This enzyme and the pneumococcal tripeptidase have been shown to be intracellular, soluble, and constitutive. In addition to their function in cleavage of peptide nutrients, these peptidases may play a role in protein synthesis and turnover.


Plasma enzyme activities in Coturnix quail fed graded doses of DDE, polychlorinated biphenyl, malathion and mercuric chloride.


Plasma triglycerides in human diabetes.

Plasma triglycerides in human diabetes.


Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP).


Pleiotropic effects of mutations involved in the regulation of Escherichia coli K-12 alkaline phosphatase. Induction of alkaline phosphatase in wild-type Escherichia coli K-12 leads to the appearance of three new proteins in addition to alkaline phosphatase in the periplasmic space of the bacteria. These proteins are detected in autoradiograms of sodium dodecyl sulfate-acrylamide gel electropherograms of extracts from cells labeled with [(35)S]methionine. Studies with constitutive mutants defective in the three genes phoS, phoT, and phoR that have been shown to regulate alkaline phosphatase synthesis indicate that the three periplasmic proteins are coregulated with alkaline phosphatase. A mutant that has a deletion in the alkaline phosphatase structural gene phoA produces the three proteins, but a newly discovered mutant phoB that has a defect in the expression of alkaline phosphatase fails to produce the three proteins. phoB mutants are shown here to be unable to make detectable amounts of alkaline phosphatase polypeptides, as measured by immunoprecipitins or acrylamide gel electropherograms. On the basis of these results we suggest a new model for the regulation of alkaline phosphatase biosynthesis. In this model, a ternary complex composed of phoB(+) and phoR(+) gene products and an internal metabolite functions as a positive control element to regulate the transcription of several cistrons coding for periplasmic proteins.


Polyglutamyl derivatives of folate as substrates and inhibitors of thymidylate synthetase.


Polyteny and the functional significance of the polytene cell cycle.


Pleiotropic effects of suppressor mutations in Bacillus subtilis. Isogenic strains of Bacillus subtilis carrying sup-1 (26), sup-3 (10), or their wild-type alleles were constructed in three genetic backgrounds. The patterns of suppression at 37 and 43.5 C, identity of mapping site, effects of the suppressor genes on growth rate, sporulation, and production of altered enzymes were examined. The similarity of the suppression pattern by sup-1 and sup-3 suggests that the suppressors are of the same type. They do not, however, represent mutations in the same gene, since, based on differences in temperature sensitivity of phage mutants in suppressor-containing hosts, sup-1 and sup-3 insert different amino acids and can coexist within the same cell. The ability to produce slow-migrating forms of enzymes of the type described in the accompanying paper was co-transferred with either of the suppressor genes during transformation, was lost on reversion of the suppressor mutations, and was independent of the genetic background. Similarly, transformation and reversion studies indicate that the additional pleiotropic properties such as slow growth rate and inability to attain competence or to yield plaques with phi105C4, which are characteristic of the Okubo sup-1 strain (HA101B) but not its early sporulation defect, result from the presence of the suppressor mutation. The possible mechanisms by which altered enzyme forms and the additional pleiotropic effects are produced in suppressor strains are discussed. In addition, a newly recognized suppressor phenotype is described and partially characterized.


Pontomedullary listeriosis in renal allograft recipient.


Possible role of adenosine deaminase in suboptimal growth of the bacillus anthracis adenine auxotroph mutant.


Potent in vitro inhibitors of tyrosinase: metal-binding fractions of tobacco smoke condensate.


Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells.


Poverty, pregnancy outcome and child development.


Practical concepts of drug absorption, distribution and loss. Serum concentrations of ampicillin were measured following administration of the drug orally and intravenously to nine normal volunteers. The results were analysed by graphic methods, and the effects of absorption, distribution and loss on the time serum concentration curve are discussed.


Practical problems in the organization of a drug trial in two hospital groups.


Preclinical toxicologic evaluation of chromomycin A3 (NSC-58 514) in mice, dogs and monkeys.


Prepaid group practice and the delivery of ambulatory care.


Preparation of a soluble, bifunctional enzyme aggregate and studies on its kinetic behaviour in polymer media.


Preparation of antisera against different animal serum proteins, using cross-reacting specific anti-human sera.


Preparation of tRNA's and aminoacyl-tRNA synthetases from Bacillus subtilis cells at various stages of growth and spores.


Preparation of vaccines--cell substrates.


Presence of amino acid dehydrogenases and transaminases in Myxococcus xanthus during vegetative growth and myxospore formation. The following enzymatic activities were demonstrated in Myxococcus xanthus during growth and myxospore formation: l-alanine dehydrogenase (EC 1.4.1.1), l-glutamic acid dehydrogenase (EC 1.4.1.2), glycine dehydrogenase (EC 1.4.1.5), l-glutamic glyoxylate aminotransferase (EC 2.6.1.4), and l-alanine glyoxylate aminotransferase (EC 2.6.1.12).


Pressure-induced dissociation of ribosomes.


Preliminary observations on antigen activity of Fasciola gigantica by immunodiffusion test in sheep.


Prevalence of irregular red cell antibodies and their significance in blood transfusion and antenatal care.


Private practice dentists--fight back. 2.


Proceedings: Mechanism of insulin release: an approach to the mode of action of sulfonylurea.


Problems in cell wall assembly.

Problems in cell wall assembly.


Proceedings: Psychological tests and drugs.


Proceedings: Some aspects of trophism in amphibian slow muscle fibres.


Production of hyperimmune serum against collagen and its use for the isolation of specific collagen peptides on immunosorbent columns.


Prognostic value of urography in irradiated cervical carcinoma.


Propagation and plaquing of Dugbe virus (an ungrouped Nigerian arbovirus) in various mammalian and arthropod cell lines.


Propanidid in epilepsy.

Propanidid in epilepsy.


Properties and inhibition of thymidylate synthetase in Drosophila melanogaster.


Prostaglandin F in the peripheral plasma of the rhesus monkey in normal pregnancy and after the administration of dexamethasone and PGF2 alpha.


Protection of rats from experimental allergic encephalomyelitis with antiserum to guinea-pig spinal cord.


Protein synthesis in Bacillus subtilis: differential effect of potassium ions on in vitro peptide chain initiation and elongation. The preparation and fractionation of a highly active and stable in vitro protein-synthesizing system from Bacillus subtilis is described. Potassium satisfied the requirement for a monovalent ion when the initiation factor-dependent binding of formyl-methionyl-transfer ribonucleic acid and synthesis of formyl-methionyl-puromycin were assayed, whereas it inhibited the reactions for polyphenylalanine synthesis. On the other hand, the ammonium ion satisfied the requirement for all assayed reactions. The in vitro experimental evidence suggested that potassium is an inhibitor of one or a few specific reactions involved in peptide chain elongation in B. subtilis.


Proteins in fluid from non-keratinizing jaw cysts. 3. Identification of individual proteins with particular reference to alpha- and beta-globulins, including fibrinogen.


Proton magnetic resonance studies of intracellular water in sickle cells.


Pulmonary edema following generalized convulsions (postictal).


Purification and partial characterization of protease from calf thymus chromatin.


Purification and characterization of Streptococcus mutans group d cell wall polysaccharide antigen. The Streptococcus mutans group d antigen of strain B13 has been purified and characterized with respect to chemical composition and immunochemical properties. The antigen was extracted from lyophilized cells or cell walls by using 5% trichloroacetic acid at 5 C for 16 h. The antigen could also be extracted with water or 0.01 N HCl at 100 C for 20 min. The antigen was purified by ion-exchange and gel chromatography and was found to contain 96% carbohydrate, 1.6% protein, and 0.3% phosphorus. Characterization by gas chromatography indicated that the polysaccharide was composed of galactose and glucose in a 2:1 ratio. The antigen contained two serologically active sites: one site specific for group d and a second site common to both group d and group a strains. Agar diffusion and immunoelectrophoresis indicated that the two sites existed on a single molecule. The immunological specificity of the group d polysaccharide site depended on a terminal d-galactose. The purified B13 antigen did not react with antisera specific for the glycerol teichoic acid from streptococci. Anti-d serum rapidly agglutinated whole cells, indicating that the antibody receptor sites of the polysaccharide antigen were at the surface of the streptococcal cell.


Purification and properties of an extracellular proteinase of psychrophilic Escherichia freundii.


Purification and properties of interference factor I: a cistron-specific translation control factor and a subunit of phage RNA replicase.


Psychopharmacology of the cannabinoids. A review.


Purification and properties of AMP-aminohydrolase from human placenta.


Purification of TF1--a template-specific DNA-binding protein and transcription inhibitor from Bacteriophage SPO1-infected Bacillus subtilis.


Protection by disodium cromoglycate in airways diseases.


Pyrroles and related compounds. XXXII. Biosynthesis of protoporphyrin-IX from coproporphyrinogen-3.


Quantification of the pituitary-thyroid axis in pregnant rats.


Pyruvate formate lyase in Rhodospirillum rubrum Ha adapted to anaerobic dark conditions.


Quantitative and comparative studies of pharmacological features in the coronary, femoral and renal circulations with different coronary vasodilators.


Radiation sterilization and the anesthetist.


Radiation-induced nondisjunction and Robertsonian translocation in Drosophila.


Radioimmunoassay of parathyroid hormone: peripheral plasma immunoreactive parathyroid hormone response to ethylenediaminetetraacetate.


Rapid screening tests for the diagnosis of bovine brucellosis by the complement fixation test.


Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity.


Rate of incorporation of tritiated thymidine into DNA of normoblastic and megaloblastic bone marrow cells in vitro.


Rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase: a comparison and immunological study of purified solubilized preparations, and alteration of enzyme levels by cholestyramine feeding.


Recent trends of isolates from cases of bacteremia in Denmark.


Recognition of two distinct groups of human IgM and IgA based on different binding to staphylococci.


Reconstitution of spinach ribulose-1,5-diphosphate carboxylase from departed subunits.


Recovery from long-term protein-energy deficiency.


Red cell life span in sickle cell trait.


Red cell and serum proteins of patas monkeys, Cercopithecus (equal Erythrocebus) patas.


Regional distribution of homocarnosine and other ninhydrin-positive substances in brains of malnourished monkeys.


Regulation of glucosylation of teichoic acid. I. Isolation of phosphoglucomutase in Bacillus subtilis 168.


Regulation of glucosylation of teichoic acid. II. Partial characterization of phosphoglucomutase in Bacillus subtilis 168.


Regulation of rat liver glycogen synthetase D. Role of glucose 6-phosphate and enzyme sulfhydryl groups in activity and glycogen binding.


Regulation of ribosome content in eukaryotes.


Reinvestigation of the physicochemical and enzymic properties of L-glutaminase from Pseudomonas.


Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition.


Relationship of oculomotor nuclei to midbrain reticular formation.


Release of mRNP-particles of the informosome type from polyribosomes of higher plant embryos.


Removal of organochlorine pesticides and polychlorinated biphenyls from marine oils during refining and hydrogenation for edible use.


Resistance to Listeria monocytogenes of guinea pigs sensitized with a simple protein.


Results of combination chemotherapy, surgery, and radiotherapy in children with neuroblastoma.


Responses to acoustic stimuli of units in the auditory cortex of awake squirrel monkeys.


Reversed haemagglutination tests for the detection of hepatitis B antigen.


Reversible inactivation by ammonia of assimilatory nitrate reductase in Cyanidium caldarium.


Role of metabolic disorders of thyroid hormones in the pathogenesis of diabetes mellitus.


Rifampicin in plasma and pleural fluid after single oral doses.


Role of physical and neuroendocrine factors in proximal electrolyte reabsorption.


Role of singlet oxygen in some chemiluminescence and enzyme oxidation reactions.


Role of the heart in the pathogenesis of endotoxin shock. A review of the clinical findings and observations on animal species.


Schizogony of Toxoplasma gondii in tissue cultures.


Seasonal variation in serum ascorbic acid and serum lipid composition of free-living baboons (Papio ursinus).


Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria.


Self administration: positive and negative reinforcing properties of morphine antagonists in rhesus monkeys.


Selective IgA deficiency in Rh-negative women.


Role of packaging in ethylene oxide sterilization.


Serological techniques for the detection of antibodies to porcine thrombocytes. I. The agglutination, fluorescent antibody and immunodiffusion techniques.


Simian lymphography.

Simian lymphography.


Role of some macro and microelements on the nitrogen fixation by the blue-green alga Calothrix sp.


Size of the chromosome of Pseudomonas aeruginosa PAO. Electron microscope examination and velocity sedimentation analysis of the deoxyribonucleic acid released from Pseudomonas aeruginosa spheroplasts indicate that this organism carries the bulk of its genetic determinants in a single duplex deoxyribonucleic acid molecule having a molecular mass of 2.1 x 10(9) daltons.


Snake venom toxins. The reactivity of the disulphide bonds of Naja nivea toxin alpha.


Sodium cromoglycate: a clinical view.

Sodium cromoglycate: a clinical view.


Solubilization and partial purification of alkaline phosphatases of sarcoma 180-TG ascites cells.


Some in vitro effects of synthetic thyrotrophin releasing factor on the secretion of thyroid stimulating hormone from the anterior pituitary gland of the domestic fowl.


Spectrophotometric titration of edetic acid in ophthalmic solutions.


Some properties of the liver-specific delta autoantigen of the rat.


Spinach leaf phosphoenolpyruvate carboxylase: purification, properties, and kinetic studies.


Spinal cord injury clinic: an approach to long-term health maintenance in the individual with spinal cord injury.


Sodium cromoglycate (cromolyn sodium): a review of its mode of action, pharmacology, therapeutic efficacy and use.


Stability of certain amino acids in a parenteral nutrition solution.


Standardization of the basic concepts in electron microscopic autoradiography.


Starvation and the glycogen of the brain and vital organs of the rhesus monkey.


Statistical estimate of the total number of operons specific for Bacillus subtilis sporulation. As an alternative to exhaustive mapping, an attempt has been made to obtain a rough estimate of the total number of sporulation operons by statistical treatment. Sixteen sporulation mutants taken at random were characterized biochemically and morphologically. The mutations they contained were mapped to determine whether they fell into any one of 23 known operons. From the proportion that do so (10/16), it is calculated that the most probable number of sporulation operons is 37 (68% confidence limits of 31 and 46). If allowance is made for the fact that two of the operons apparently contain mutagenic "hot spots" and the calculation is amended accordingly, the most probable numbers of operons becomes 42 (limits 33 and 59).


Stones in common bile duct: non-operative management.


Structural and immunologic characteristics of subviral components of Sindbis, eastern equine and western equine encephalitis viruses.


Structure of haemoglobin Wien beta 130 (H8) tyrosine-aspartic acid: an unstable haemoglobin variant.


Structure of the oocyst and excystation of sporozoites of Isospora endocallimici n. sp., from the marmoset Callimico goeldii.


Structure-activity relationships in narcotic antagonists with N-furylmethyl substituents.


Studies of folate compounds in nature. Folate compounds in rat kidney and red blood cells.


Studies of bactericidal activity to Escherichia coli of porcine serum and colostral immunoglobulins and the role of lysozyme with secretory IgA.


Studies of human kidney antigens.

Studies of human kidney antigens.


Studies of prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro.


Studies of Pseudomonas aeruginosa infections among hospitalized patients. I. Isolation and identification of nonfermentative gram-negative rods.


Studies on liver aldolases in hereditary fructose intolerance.


Studies on slices and isolated cells from fresh osteoarthritic human bone.


Studies on the bacteriolytic activity of Streptomyces albus culture filtrates. 1. The effect of variations in cultivation conditions and the screening of various enzyme specificities.


Studies on the bacteriolytic activity of Streptomyces albus culture filtrates. 2. Fractionation on ion-exchange chromatography and gel filtration.


Studies on the bacteriolytic activity of Streptomyces albus culture filtrates. 3. Affinity for chitin.


Studies on the exoerythrocytic stages of simian malaria. IX. Plasmodium simium.


Studies on the control of development. In vitro synthesis of HPN and MS nucleotides by ribosomes from either sporulating or vegetative cells of Bacillus subtilis.


Studies on the inhibition of oxotremorine induced tremor by a melanocyte-stimulating hormone release-inhibiting factor, thyrotropin releasing hormone and related peptides.


Studies on the phosphorylation of nucleolar proteins. Comparison of the phosphorylation patterns of nuclear and nucleolar proteins labeled in vivo and in vitro.


Studies on C4 inactivator induced by adenoviruses in KB cell cultures.


Study on the in vitro Rieder cell.

Study on the in vitro Rieder cell.


Subcellular localization and properties of thymidine kinase from adenovirus-infected cells.