The effect of homologous and heterologous carriers on the immunogenicity of the galactocerebroside hapten.


A psychoanalytic psychotherapy of a patient with cerebral palsy: the relation of aggression to self and body representations.


Cellular regulation in sexual development.


Evaluation of media used for cultures of Neisseria gonorrhoeae and comparison of commercial and laboratory prepared supplements.


Microepidemic of virulent gonococcal infection.


Criteria for cure of gonorrhea. How reliable are they?


Evaluation of self-obtained cultures using a vaginal tampon as a method of screening for asymptomatic gonorrhea on a college campus.


Steffimycin B, a new member of the steffimycin family: isolation and characterization.


Microbial production of vitamin B12 antimetabolites. I. N5-hydroxy-L-arginine from Bacillus cereus 439.


Aminoglycoside antibiotics. VII. Synthesis and activity of 4'-deoxykanamycin A.


Aminoglycoside antibiotics. IX. 1-N-acyl derivatives of kanamycin A (amikacin analogs).


The mode of action of polyketoacidomycin on Bacillus subtilis.


On the mode of action of ASK-753, a new iron-containing antibiotic.


The synthesis of 1-N-[(S)-4-amino-2-hydroxybutyryl]gentamicin C1 and 1-N-[ (S) -3-amino-2-hydroxypropionyl]gentamicin C1.


Studies on the biosynthesis and morphogenesis of R-type pyocins of Pseudomonas aeruginosa. IV. Quantitative estimation of the rates of synthesis of pyocin R subunit proteins.


Phosphoenolpyruvate carboxylating enzyme in dark-grown and in green Euglena cells.


Lack of exchange of ribosomal structural proteins with cell-sap proteins of rat liver in vitro.


Inhibition by analogues of the hydrolysis of phenyl alpha-maltoside catalyzed by saccharifying alpha-amylase from Bacillus subtilis.


Ectopic ossification following total hip replacement. Incidence and a method of classification.


Rickets, osteomalacia, and renal osteodystrophy. Part II.


Glutaraldehyde fixation of isolated eucaryotic nuclei. Evidence for histone-histone proximity. Isolated chicken erythrocyte nuclei have been incubated with dilute concentrations of the bifunctional cross-linking agent glutaraldehyde (0-20 mM) in order to stabilize histone-histone interactions within the native nucleus. The kinetics of the disappearance of acid-soluble histones, free amino groups, and of individual histones have been observed to be pseudo first-order. Apparent first-order rate constants for the disappearance of individual histones correlate with the lysine mole percent of that fraction and follow the ranking, k(app): F1 > F2C > F2B >/= F2A2, F2A1, F3. Histone polymers were observed to form very rapidly during the fixation reaction. Partial fractionation and amino acid analyses of these polymers support the view that they are composed principally of cross-linked (F2C)(n) molecules (where n = 2 to approximately 8). The rate of glutaraldehyde reaction with free amino groups in histones is drastically reduced in solvents that promote chromatin decondensation (i.e., low ionic strengths in the absence of divalent cations) whereas the formation of cross-linked F2C polymers is less severely reduced. It is proposed that some F2C histones exist in close proximity within the isolated erythrocyte nucleus.


Development of high resolution pyrolysis-gas chromatography for the identification of microorganisms.


The synthesis and turnover of rat liver of rat liver peroxisomes. IV. Biochemical pathway of catalase synthesis. Early events in the biosynthesis of liver catalase were studied on female rats receiving [(3)H]leucine or [(3)H]delta-aminolevulinic acid or a mixture of [(3)H]leucine with [(14)C]delta-aminolevulinic acid by intraportal injection. Catalase antigen was selectively separated from homogenates by immunoprecipitation, both without and after partial purification of the enzyme. Label from both precursors appeared first in immunoprecipitable material which was lost upon purification of catalase; the label subsequently became associated with material indistinguishable from catalase. Kinetic analysis of the results indicates that the nonpurifiable material identified by early labeling consists of two distinct biosynthetic intermediates, the first lacking heme and representing about 1.6% of the total catalase content or 13 microg/g liver, the second containing heme and representing about 0.5% of the total catalase content or 4 microg/g liver. The first intermediate migrates at the same rate as catalase upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and therefore has a monomeric molecular weight of about 60,000.


The pre-albumin fraction: a useful parameter in the interpretation of routine protein electrophoresis. A technique of protein electrophoresis suitable for routine use which ensures good separation of the prealbumin fraction is described. The clinical value of visually estimating this protein fraction from the electrophoretic strip is shown with reference to 134 cases. Low levels of prealbumin were found to be associated with liver disorders, malignancy, collagen diseases, congestive cardiac failure, and burns. Finally, pitfalls in electrophoretic technique which may cause failure to visualize the prealbumin fraction are discussed.


The effect of age upon the coagulation system. Factors V, VII, VIII, X, XI, and XII of the coagulation system, platelet count, and antithrombin III levels were assayed in 20 healthy volunteers aged 20-40 years and 61 elderly subjects aged 66-96 years whose skinfold thickness was also measured. Factors XI, XII, and antithrombin III levels tended to increase in women and decrease in men while factors X, VII, and V tended to increase in both males and females with advancing years. No age or sex differences were found in platelet counts or factor VIII levels. Factor VIII levels were inversely correlated with obesity in elderly males (r = -0.56, p < 0.005).


Chlorhexidine in dental practice.

Chlorhexidine in dental practice.


Bacterial flora of the appendix fossa in appendicitis and postoperative wound infection. Bacteria were isolated from 153 (47.5%) swabs of the appendix fossa in 322 patients undergoing appendicectomy. The commonest organism was Bacteroides species found in 78% of specimens. Other Gram-negative bacilli such as Klebsiella, or Enterobacter, and Esch. coli were present in 29 and 27% respectively. Gram-positive cocci were less frequently isolated.A positive culture was obtained more commonly in perforated appendicitis (79%) than where chronic fibrosis, lymphoid hyperplasia, or acute appendicitis was present or when the appendix was normal. Bacteroides was isolated twice as often in perforated appendicitis. The incidence of wound infection was 19% and varied according to the state of the appendix, being 63% in perforated appendicitis and 9.5% where lymphoid hyperplasia was present. Bacteroides was isolated from over 90% of the wound infections. In the patients with perforated appendicitis where effective chemotherapy was given the incidence of wound infection was 15% whereas in untreated or inappropriately treated patients it was over 50%. The isolation of bacteroides requires special precautions to be taken both in the collection of the specimen and laboratory culture. It is important that the chemotherapy of postappendicectomy infections include an antibiotic active against bacteroides.


Hepatitis-associated antigen in various population groups in Upper Egypt.


Hepatitis and hepatitis-associated antigen (Au) in Upper Egypt.


Oral management of uncomplicated maturity onset diabetes.


Side effects of IV fructose load in diabetics.


Immunologic relationship between the bactericidal fraction of neurotoxin and the protein from Salmonella typhimurium "S" endotoxin.


The immunochemical investigations of endotoxins of asporulating gram negative rods (genus Sphaerophorus and Eggerthella).


Fever and sleep cycle changes caused by bacterial products.


Immunochemical and toxic properties of the lipopolysaccharides from highly and low virulent Pseudomonas aeruginosa strains.


The Rhesus factor in occlusive and ectatic arterial disease.


A clinical trial of reserpine--clopamide--dihydroergocristine in the treatment of hypertension.


Some factors affecting the detection of long-acting thyroid stimulator protector using the McKenzie bioassay.


Six years experience with pelvic inflammatory disease.


Free fatty acids, diacyl- and triacylglycerols and total phospholipids in vertebrate retina: comparison with brain, choroid and plasma.


Human placental lactogen levels in amniotic fluid in rhesus isoimmunization.


The effect of copper deficiency on the mandibular joint and alveolar bone of pigs.


Longitudinal studies in oral leukoplakias.


The calcifying ghost cell odontogenic tumor - or the calcifying odontogenic cyst.


Lignans from Larrea divaricata.

Lignans from Larrea divaricata.


Structure of antibodies.

Structure of antibodies.


Modern radiation therapy of carcinoma of the prostate.


The prevalence of long-term illness in a family practice.


Calcium ions and control of the motility of sea urchin spermatozoa.


The incidence of Brucella ovis infection in South African rams: a serological survey.


Brucellosis in Rhodesian Wildlife.

Brucellosis in Rhodesian Wildlife.


Anthrax in an African buffalo (Syncerus caffer) in the Kruger National Park.


Editorial: Monkeys, models, and midwives.


Heteroagglutinins in human sera specific for erythrocytes of nonhuman primates.


Antimicrobial effectiveness ofkanamycin, aminosidin, BB-K8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against gram-negative rods.


Recent developments of biomedical research in nonhuman primates. With a short historical review.


Cholesterol gallstones in Aotus trivirgatus.


Paramyosin of Caenorhabditis elegans.

Paramyosin of Caenorhabditis elegans.


Chromosomes segregration and development in Caulobacter crescentus.


Effect of glutaraldehyde and urea embedding on intracellular ionic elements. X-ray microanalysis of skeletal muscle and myocardium.


Structural variability of immunoglobulins.


Single radial diffusion using catalase antibody as screening method of hypocatalasemia.


Ethnic characteristics of the kappa : lambda ratio of immunoglobulins in health and disease of the Japanes and Occidental.


Antigenic analyses of sequential isolates of Coxsackie A16 virus from 1964 to 1970 in Japan.


Effect of CaEDTA administration on urinary hydroxyproline excretion and skin wound healing in the rat.


Healing of lined and unlined parasitic and nonparasitic flaps.


Structural components of measles virus.

Structural components of measles virus.


Intracellular accumulation of measles virus nucleocapsid and envelope antigens.


[Isolation of murein-free spheroplast ghosts from a strain of Escherichia coli K 12].


The use of Microstix in the diagnosis of urinary tract infections.


Diuretics, cardiac failure and potassium depletion: a rational approach.


Surgical drapes and their permeability to bacteria.


Renaturation of denatured DNA in NaI gradients.


Single-drug therapy in ovarian cancer.

Single-drug therapy in ovarian cancer.


Identification and typing of viruses and detection of antiviral antibodies by counterimmunoelectrophoresis.


F antigen. I. Purification and polymorphism.


Laser damage to ocular tissues.

Laser damage to ocular tissues.


Ocular examination of laser workers and investigation of accidents.


Laser safety codes.

Laser safety codes.


Physiological actions of prolactin.

Physiological actions of prolactin.


Radioimmunoassay of human prolactin.

Radioimmunoassay of human prolactin.


Prolactin studies in normal subjects.

Prolactin studies in normal subjects.


Systemic sarcoidosis with massive hepatic involvement.


Immunological and clinical findings in workers and consumers exposed to enzymes of Bacillus subtilis.


A technique of after-loading: high dose-rates.


Clinical findings in workers exposed to the enzymes of Bacillus subtilis.


Letter: The calculation of ionization chamber collection efficiency for pulsed beams.


Radiotherapy of testicular tumours.

Radiotherapy of testicular tumours.


Immunodeficiency: enigmas and speculations.


Surface immunoglobulins on human lymphoid cells.


Therapeutic uses of transfer factor.

Therapeutic uses of transfer factor.


Toxicity of propellants.

Toxicity of propellants.


The use of the antiglobulin test in the diagnosis of bovine brucellosis.


Parenteral infection of laboratory animals with metacercariae of Fasciola hepatica.


Duration of serological response to the indirect fluorescent antibody test of cattle recovered from Theileria parva infection.


Natural resistance to infection in the newborn sheep: competence of local and and systemic defences in normally-sukled and colostrum-deprived lambs.


The detection of tuberculin-sensitive lymphocytes from bovine blood by uptake of radio-labelled nucleosides.


Distribution of Brucella antibody among immunoglobulin classes and a low molecular weight antibody fraction in serum and whey of cattle.


Changes in the serum immunoglobulin levels of colostrum-fed calves during the first 12 weeks postpartum.


The influence of endocrine and exocrine pancreas on the carbonic anhydrase activity of the rat salivary glands.


The effect of stimulation of central end of the vagus on the phrenic activity after strichnine and picroxin.


Morphological examinations of pancreatic tissue in dog with acute pancreatitis.


Differential thermal analysis of oral and palmar epithelium.


A mutant of Bacillus subtilis with impaired ability for recombination and reduced activity of the enzyme ATP-dependent deoxyribonuclease.


Deposits of immunoglobulins and complement in oral lupus erythematosus.


Distribution of defective chromosomes in human cells after treatment with chemical mutagens in vitro and in vivo.


Calibration and measurement of potassium-40 with a whole-body counter.


Transport of materials in the suctorian tentacle.


Pathways of nucleocytoplasmic translocation of ribonucleoproteins.


Electronic platelet counting after isopycnic differential centrifugation a simple rapid and accurate method. A semi-automatized platelet counting procedure with the use of a Coulter Counter is described. Its originality consists in providing an electronic method of counting of the platelets after a differential centrifugation of the blood sample previously diluted with a hypertonic NaCl solution (density 1.053) which is isopycnic to platelet density. This procedure allows elimination of red and white cells without loss of platelets in the supernatant. The final platelet number can be calculated without further corrections. The method is quick and does not require specially skilled technicians. A single technician can perform 40 counts in one hour. The reproductibility of the method is excellent and the coefficient of variation 2,4%. The accuracy and feasibility of the method is also sustained by two years' experience in an haematological routine laboratory.


Fibrinogen Valencia. A new case of congenital dysfibrinogenemia.


Separation and characterization of immunoglobulin classes of anti-salmon sperm deoxyribonucleic acid antibodies in rabbits.


Regeneration and functional recovery of canine intestinal mucosa following injury caused by formalin.


The ultrastructural effects of aflatoxin B1 in the rat pancreas.


Aurosomes in rabbit articular cartilage.


A scanning electron microscope study of the glomerulus of normal and nephritic rabbits.


Immunofluorescent studies on the occurrence of cathepsin B1 at tumor cell surfaces.


From studies on the parasitic Ciliata invading plant-feeding species of fish in ponds.


Nutrition after injury.

Nutrition after injury.


The economics of human parasitic infections.


Advances in the biology of sporozoa.

Advances in the biology of sporozoa.


Advances in the immunodiagnosis of parasitic infections.


Australia antigen (Au(1), HAA, HABg) in expatriates living in Ibadan, Nigeria.


Studies of the actions of thiols, lithium ions and insulin on carbohydrate metabolism of the isolated rat diaphragm.


Proceedings: Effects of centrophenoxine and palmitoylethanolamide in rats with early protein and calorie malnutrition. I. Neurological tests.


Proceedings: The effects of centrophenoxine and palmitoylethanolamide in rats with early protein and calorie malnutrition. II. Somatic and biochemical parameters.


Transfer of TRH through the placenta and metabolism in the fetus of the guinea-pig.


A serum factor influencing the physiological activity of thyrotropin-releasing hormone (TRH) I. Studies with human serum.


A serum factor influencing the physiological activity of thyrotropin-releasing hormone (TRH). II. Studies with rat serum in vivo and in vitro.


Autoradiographic - histochemical demonstration of tyrosinase activity in melanin-forming tissues of mammals.


Vascular supply of the rat medial basal hypothalamus and development of vascular connections between this region and the rest of the brain following deafferentation of the former area.


"Monoclonal" IgM-gammopathy with two different light-chain types of protein (Bence-Jones I and II).


Experimental chemotherapy of Schistosomiasis mansoni.


Corynebacterium pyrogenes; a biochemical and serological study.


Estrone and progesterone plasma levels of normal cows and cows with parturient paresis.


The occurrence of antibodies against staphylococcal deoxyribonucleases in blood sera from different species.


Serum levels of the immunoglobulins IgG and IgG(T) in horses.


Inhibition of the diuretic action of glibenclamide by clofibrate, carbamazepine and 1-deamino-8-d-arginine-vasopressin (DDAVP) in patients with pituitary diabetes insipidus.


Morphological alterations of Pseudomonas aeruginosa by ticarcillin: a scanning electron microscope study. Pseudomonas aeruginosa was exposed to 0.1, 1.0, 10, 100, and 1,000 times the minimal inhibitory concentration of ticarcillin in vitro and subsequently examined with the scanning electron microscope. The morphological alterations observed were filamentation, mid-cell defects, and spheroplast formation, and these alterations were dependent upon the drug concentration.


Evaluation of antigen-coated red cells for detection of serum hepatitis antigen and antibody.


Formation of protoplasts in Azotobacter vinelandii.


Use of a triple layer enzyme method as an alternative to immunofluorescence for the detection of tissue antigens.


Intoxication, detoxication and copper-storage of central nervous tissue at different external Cu(II)-concentrations.


Rapid titration of dengue virus type 4 infectivity by counting fluorescent foci.


Purification of human placental alkaline phosphatase. Salt effects in affinity chromatography. Human placental alkaline phosphatase was chromatographed on Sepharose derivatives of d- and l-phenylalanine, l-leucine, glycine, aniline and p-aminobenzoic acid in high concentrations of (NH(4))(2)SO(4). Retention on these columns was greatest at the highest concentrations of (NH(4))(2)SO(4). By using decreasing concentrations and changing the types of salts, elution was effected from each of the columns. The (NH(4))(2)SO(4)-mediated retention appeared to be related to the hydrophobic character of the substituted Sepharose, rather than to any specific binding site of the enzyme. It is suggested that this provides a way of controlling hydrophobic affinity chromatography. By use of chromatography on l-phenylalanine-Sepharose and of DEAE-Sephadex chromatography in the presence of Triton X-100 detergent, a preparation of highly purified (1000-fold) human placental alkaline phosphatase was obtained in 22% yield.


An electron-capture gas-liquid-chromatographic method for the determination of prostaglandin F2alpha in biological fluids. A sensitive electron-capture gas-liquid-chromatographic method for the determination of sub-nanogram quantities of prostaglandin F(2alpha) was developed. The method is based on the sub-microgram scale conversion of the prostaglandin into the electron-capturing pentafluorobenzyl ester, and analysis of the latter as the tris-trimethylsilyl ether. The lower limit of detection was 12.5pg of the ester injected ;on-column' as the silylated product. The method was successfully applied to the determination of prostaglandin F(2alpha) in monkey plasma. The specificity of the analytical procedure was increased by incorporating a thin-layer chromatographic fractionation before gas-liquid chromatography. The utility of the analytical methodology developed was demonstrated by its application to the determination of plasma concentrations of intact prostaglandin F(2alpha) in a Rhesus monkey, after subcutaneous administration of a single dose of prostaglandin F(2alpha). The electron-capture gas-liquid-chromatographic assay is compared with the radioimmunoassay and the gas-liquid-chromatographic-mass-spectrometry assay for the determination of prostaglandin F(2alpha).


Thermal inactivation studies of normal and variant human erythrocyte carbonic anhydrases by using a sulphonamide-binding assay. Heat-inactivation studies were carried out on the two primary erythrocyte carbonic anhydrase isoenzymes, CA I and CA II, and the secondary isoenzyme of CA I, CA I (+1). In addition, two genetic variants of human isoenzyme CA I, CA Id Michigan (100 Thr-->Lys) and CA If London (102 Glu-->Lys), and one variant of isoenzyme CA II, CA IIh (251 Asn-->Asp), were similarly analysed. The first-order rate constants and Arrhenius plots for these six enzyme forms showed that (1) isoenzyme CA II is more heat-stable than CA I, (2) isoenzyme CA I (+1) is less heat-stable than CA I, (3) the variants CA IIh and CA If London are less heat-stable than the normal enzymes, and (4) isoenzyme CA Id Michigan is more heat-stable than normal CA I. From the values of the slopes of the Arrhenius plots, the energy of activation (E(a)) for each isoenzyme and isoenzyme variant was determined, and the following thermodynamic activation parameters were calculated at 55 degrees C: the free energy of activation (DeltaG(double dagger)), the activation enthalpy (DeltaH(double dagger)) and the activation entropy (DeltaS(double dagger)). The DeltaG(double dagger) for the enzymes shows a relative constancy with compensating variation in DeltaH(double dagger) and DeltaS(double dagger). When the values for DeltaH(double dagger) are plotted against DeltaS(double dagger), an increase in DeltaH(double dagger) involves a concomitant increase in DeltaS(double dagger).


Chemical and immunochemical characteristics of tropomyosins from striated and smooth muscle. 1. On electrophoresis in dissociating conditions the tropomyosins isolated from skeletal muscles of mammalian, avian and amphibian species migrated as two components. These were comparable with the alpha and beta subunits of tropomyosin present in rabbit skeletal muscle. 2. The alpha and beta components of all skeletal-muscle tropomyosins contained 1 and 2 residues of cysteine per 34000g respectively. 3. The ratio of the amounts of alpha and beta subunit present in skeletal muscle tropomyosins was characteristic for the muscle type. Muscle consisting of slow red fibres contained a greater proportion of beta-tropomyosin than muscles consisting predominantly of white fast fibres. 4. Mammalian and avian cardiac muscle tropomyosins consisted of alpha-tropomyosin only. 5. Mammalian and avian smooth-muscle tropomyosins differed both chemically and immunologically from striated-muscle tropomyosins. 6. Antibody raised against rabbit skeletal alpha-tropomyosin was species non-specific, reacting with all other striated muscle alpha-tropomyosin subunits tested. 7. Antibody raised against rabbit skeletal beta-tropomyosin subunit was species-specific.


Comparison of the biliproteins from two strains of the thermophilic cyanophyte Synechococcus lividus. C-Phycocyanins from two thermophilic strains of Synechococcus lividus that grow within different temperature ranges have been shown to be unalike. The aggregation ability of these two C-phycocyanins in sedimentation-velocity experiments varied dramatically. Surprisingly, the aggregation properties of mesophilic C-phycocyanins were found to lie between those of the two thermophilic proteins. Under identical conditions at pH7.0, one thermophilic protein (Sy I) was composed of 17S and larger aggregates, whereas the other (Sy III) was an almost homogeneous 6S aggregate. Mesophilic C-phycocyanins have a mixture of 6S, 11S and less stable 17S aggregates under these conditions. Amino acid analysis, absorption spectra, immunochemistry and fluorescence polarization all indicated differences in the composition and properties of the thermophilic proteins, which suggest that they have different modes of adaptation to very high temperatures. Allophycocyanins from the two strains of S. lividus were also purified and studied, but unlike the C-phycocyanins no major differences were found between them. Allophycocyanin was homogeneous at pH6.0, with a sedimentation coefficient of 5.54S and mol.wt. 1.03x10(5), as determined by sedimentation-equilibrium measurements.


A more detailed study of bile salt evolution, including techniques for small-scale identification and their application to amphibian biles. 1. Methods have been developed for the isolation and identification of small amounts of bile salts and of bile acids and alcohols obtained by solvolysis. These methods involve preparative and analytical t.l.c., purification on columns of protonated Al(2)O(3) and Sephadex LH-20 and also g.l.c.-mass spectroscopy of solvolysis products. 2. Application to 29 species of frogs and toads has confirmed the constancy of bile salt patterns in a single species, including colour phases in two instances, and has revealed great variations between different species in some genera (e.g. Rana, Ptychadena) and little difference between widely distributed species in others (e.g. Bufo). 3. Taxonomic deductions should be made with caution and with regard to the physiological significance of the biochemical character considered. The molecular differences found might be interpreted as indicating variations in the rate of evolution.


Pyruvate and nitrogenase activity in cell-free extracts of the blue-green alga Anabaena cylindrica.


The amino acid sequence of the C- terminal cyanogen bromide peptide of human J chain.


Morquio's syndrome: deficiency of a chondroitin sulfate N-acetylhexosamine sulfate sulfatase.


Identification of several unique low molecular weight basic proteins in dormant spores of Bacillus megaterium and their degradation during spore germination.


Amino acid sequence of Streptomyces griseus protease B, A MAJOR COMPONENT OF Pronase.


The occurrence of a transmethylation reaction not involving S-adenosylmethionine in the formation of ribothymidine in Bacillus subtilis transfer-RNA.


Decarboxylation of long chain fatty acids to alkanes by cell free preparations of pea leaves (Pisum sativum).


Proton Magnetic resonance observations of hydrogen exchange rates and secondary structure in algal ferredoxin.


Crystallisation of purified thyroxine-binding alpha globulin.


Deficiency of chondroitin sulfate N-acetylgalactosamine 4-sulfate sulfatase in Maroteaux-Lamy syndrome.


Effect of silybin on the hepatic microsomal drug-metabolising enzyme system in the rat.


The effect of sex difference on iron exchange in the rat.


Ocular histoplasmosis syndrome in the United Kingdom.


Studies on the radiation-induced dissociation and reassociation of polysomes in Tetrahymena pyriformis.


A comparative examination of amphibian sperm proteolytic activity.


Machine for the automatic washing of red blood cells and its use in the assay of anti-D antibody.


Immunosuppression and experimental tuberculosis. II. The effects of immunosuppressive agents and antilymphocyte serum on the organ dissemination of mycobacteria and on the development of specific delayed hypersensitivity.


Interactions of PCBs, DDT and DDE in a marine diatom.


Determination of pentachlorophenol and chlorobiphenylols in biological samples.


Co-carcinogenic effect of DDT and PCB feeding on methylcholanthrene-induced chemical carcinogenesis.


PCB residues in plankton and sediment in the southwestern coast of Finland.


Clinical and EEG studies of prisoners charged with murder.


The potential of coenzyme Q 10 (NSC-140865) in cancer treatment.


Antigen binding to lymphoid cells from unimmunized mice: high frequency of beta-galactosidase binding cells at optimal conditions.


Kinetics of B cell memory development during a thymus "independent" immune response.


Acquired cellular immunity: extracellular killing of Listeria monocytogenes by a product of immunologically activated macrophages.


Observations on migration inhibition of sensitized peritoneal exudate cells as a function of time.


Cooperation of three lymphoid cells in allograft rejection.


Immunoglobulin on activated T cells detected by indirect immunofluorescence.


Characterization of contrasensitizing antibodies.


In vitro suppression ofimmunoglobulin allotype synthesis by Fab and F(ab')2 fragments of anti-allotype antibody.


Immunology of Chagas' disease.

Immunology of Chagas' disease. After reviewing present knowledge of the morphology, multiplication, and transmission of Trypanosoma cruzi, this Memorandum discusses the animal models that may be of value in understanding the immune mechanisms operating in Chagas' disease. The role of both circulating antibody and cell-mediated immunity in protection against the parasite is discussed, together with the possibility that immunopathological mechanisms may be responsible for some of the lesions found in patients with Chagas' disease. The immunodiagnostic methods at present available are also reviewed, and the possibility of producing a vaccine for human use is considered in the light of recent findings in experimental animals. A series of recommendations for further research is included.


Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic 'drift' for the Hong Kong virus. A new antigenic variant of the Hong Kong (H3N2) subtype of influenzavirus type A is described. The variant, A/Port Chalmers/1/73 (H3N2), was first isolated in Australasia in the autumn of 1973 and subsequently became the predominant influenza A variant in most areas of the world, replacing the previously prevalent strain A/England/42/72 (H3N2). The 1973 variant shows antigenic differences from former Hong Kong variants in both haemagglutinin and neuraminidase antigens. The application of immuno-double-diffusion tests and single-radial-diffusion tests in the antigenic analysis of new variants of the influenzavirus is also described. It is emphasized that since new variants of the Hong Kong virus have appeared in the successive years 1971, 1972, and 1973, the annual frequency of antigenic "drift" for the Hong Kong virus is higher than was recorded for the "Asian" influenzavirus (H2N2) in the first 5 years of the latter's prevalence from 1957 to 1962, during which period little antigenic variation occurred.


A simple technique for culturing tubercle bacilli. Microscopy, traditionally used in peripheral health centres to diagnose tuberculosis, could be supplemented by sputum culture if sputum specimens were inoculated on suitable media and sent to intermediate or central laboratories to be incubated and read. To facilitate this procedure, the authors propose a simplified swab culture method and a modification of Ogawa's egg medium.


Physiology and treatment of hypoxia.

Physiology and treatment of hypoxia.


Immunochemical investigation of the antigens of drug-resistant staphylococcal strains.


Some aspects of methicillin-resistance of Staphylococcus aureus.


In vitro effects of staphylococcal alpha and delta toxins on liver mitochondria.


Staphylococcal hyaluronate lyase.

Staphylococcal hyaluronate lyase.


Bacteriological control of dissemination of Staphylococcus aureus at an intensive care unit.


Epidemiology of enterotoxic strains of Staphylococcus aureus.


"Steady-state" properties of the baroreceptor-heart rate reflex in essential hypertension in man.


Serological types of enterotoxins produced by strains of Staphylococcus aureus isolated from feces.


Total parenteral nutrition. Experience with 180 patients.


Coronary haemodynamic effects of nifedipine (Bay a 1040) and glyceryl trinitrate in unanaesthetized dogs.


Structure and immunology of protein A.

Structure and immunology of protein A.


Effect of individual ingredients of fortified skim milk as suspending media on survival of freeze-dried cells of Streptococcus lactis.


Comparative trial of tinidazole and metronidazole in intestinal amebiasis.


Effect of carbohydrates and related compounds on the long-term preservation of freeze-dried bacteria.


A double-blind comparison of phenylbutazone and aspirin in osteoarthritis.


Migraleve in the prophylaxis of migraine.


Sensitivity of Pseudomonas aeruginosa to carbenicillin: an evaluation of susceptibility testing after four years of clinical usage.


Comparison of migraleve and buclizine in prophylaxis of migraine.


Studies on immunodiagnosis of angiostrongyliasis. 5. Double immunodiffusion and counterelectrophoresis for detection of antibody in infected rat and human sera.


Comparison of the sequences of macro- and micronuclear DNA of Tetrahymena pyriformis.


Thyrotrophin-releasing hormone in diagnosis.


The genes for ribosomal RNA in diploid and polytene chromosomes of Drosophila melanogaster.


The dysmorphogenic potential of phenytoin: experimental observations.


Metabolic aspects of methylcyclopentadienyl manganese tricarbonyl in rats.


Biological fate of -103Pd in rats following different routes of exposure.


Some effects of DDT and PCB on the hormonal system in the male mouse.


Immunological studies on glutamate dehydrogenase from the cytoplasmatic fraction of rat liver.


Immunoglobulin synthesis and glucose-6-phosphate dehydrogenase as cell markers in human lymphoblastoid cell lines.


Ghost monolayers in the study of the modulation of transcription in cultures of CV1 fibroblasts.


Partition coefficient of membrane particles in the fusion rosette.


Ultrastructural detection of single-stranded DNA in rat liver nucleus by the electronmicroscopic immuno-peroxidase method.


Stable nuclear RNA returns to post-division nuclei following release to the cytoplasm during mitosis.


Induction of fertilization membrane by ionophore A23187 in sea urchin egg Paracentrotus lividus.


Neuropathy in mucopolysaccharidosis type 3.


Circadian rhythm in size and 3H-uridine incorporation of single puffs of Drosophila salivary glands in vitro.


Mitogenic stimulation of human leukemic plasma cells.


The Bacillus Subtilis genome: replication-order and map-position discrepancies--evidence for a second origin. Replication order to map position discrepancies have been documented in B. subtilis. The discrepancies were found to occur whenever the genome of B. subtilis was replicated under a variety of physiological conditions and in both 168 and W23 strains. The earliest replicating marker involved in these discrepancies was thr versus purB and aroA versus recA. A detailed linkage analysis of the ura to argA region was consistent with its being a continuous linkage group. This led to the conclusion that an origin for new starts at replication exists between recA and aroA.


The ribosomes of Drosophila. II. Studies on intraspecific variation. Electrophoretic comparisons of 40S and 55S ribosomal subunit proteins from 18 strains of Drosophila melanogaster revealed the virtual absence of allelic variation. More detailed two-dimensional studies on the large subunit proteins in 6 of the strains demonstrated additional complexity but still no interstrain variation. The significance of these results is discussed with respect to present estimates of genic heterozygosity in natural populations.


Concurrent multiple paternity in natural and laboratory populations of Drosophila melanogaster. Electrophoretic analysis of two or three linked enzyme loci in progenies of homozygous females from cage and natural populations demonstrates frequent concurrent multiple paternity in both cases.


The genetic variance for viability and its components in a local population of Drosophila melanogaster. Two hundred and ninety second chromosomes extracted from a natural population of Drosophila melanogaster were analyzed to estimate the genetic variance of viability and its components by means of a partial diallel cross (Design II of Comstock and Robinson 1952). The additive and dominance variances are estimated to be 0.009 and 0.0012. Using the dominance variance and the inbreeding depression, the effective number of overdominant loci contributing to the variance in viability is estimated to be very small, a dozen or less. Either the actual number of loci is small, or the distribution of viabilities is strongly skewed with a large majority of very weakly selected loci. The additive variance in viability appears to be too large to be accounted for by recurrent harmful mutants or by overdominant loci at equilibrium with various genetic parameters estimated independently. The excess might be due to frequency-dependent selection, to negative correlations between viability and fertility, or possibly to the presence of a mutator. The selection for viability and fertility, or possibly to the presence of a mutator. The selection for viability at the average polymorphic locus must be very slight, of the order of 10(-3) or less.


Variation of spontaneous occurrence rates of chromosomal aberrations in the second chromosomes of Drosophila melanogaster. After accumulating mutations by the aid of marked inversions, spontaneous occurrence rates of chromosome aberrations were estimated for 1148 chromosome lines that originated from five stem line second chromosomes of Drosophila melanogaster. In chromosome lines originating from three stem chromosomes (CH, PQ, and RT), mutations were accumulated for 7550, 7252, and 7256 chromosome generations, respectively, but no structural change was detected. For the chromosome lines that originated from the other two stem chromosomes, the situation was different: Twenty aberrations (19 paracentric inversions and 1 translocation between the second and the third chromosomes) during 45990 chromosome generations took place in the 500 chromosome lines derived from stem line chromosome (AW), and 92 aberrations (83 paracentric inversions, 6 pericentric inversions, 2 translocations between the second and the third chromosomes and 1 transposition) arose during 45006 chromosome generations in the 500 chromosome lines derived from stem line chromosome (JH). For the AW group the occurrence rate becomes 0.00043 per chromosome per generation for all aberrations and 0.00041 for inversions. For the JH group the corresponding rates are 0.00204 and 0.00198, respectively.-A non-random distribution of the breakpoint on the salivary gland chromosome was observed and the breakpoints were concentrated in the regions 26, 29, 33, and 34.-The cytoplasms and the chromosomes (other than the second chromosomes) were made approximately uniform throughout the experiments. Thus, this remarkable variability in the occurrence rate is most probably due to the differences in one or more chromosomal elements on the original five stem chromosomes. The mutable chromosomes (AW and JH) appear to carry a kind of mutator factor such as hi (Ives 1950).


Sideroblastic anaemia and jejunal diverticulosis.


Reversibility of atherosclerosis.

Reversibility of atherosclerosis.


Partial unilateral lentiginosis with associated developmental abnormalities.


The role of radical hysterectomy in adenocarcinoma of the endometrium.


Reactive haemolysis test in paroxysmal nocturnal haemoglobinuria.


Autoradiographic and cytophotometric studies on granulocyte precursors in chronic myeloid leukaemia.


[Chronic idiopathic acquired hypogammaglobulinemia with hypersplenism, sarcoid-like arthritis and dermatomyositis. Report of a case (author's transl)].


Changes in the neurosecretory apparatus of protein malnurished rats.


Effects of radiations on the rate of regeneration in Homalozoon vermiculare (STokes) & Urostyla.


'Diverticulosis' of the fish duodenum infested with cestodes.


Pseudomonas aeruginosa in post operative wound infection.


Perinatal observations of mother-infant behaviour in the bonnet macaque.


Case studies in bioethics. Saying "no" to hemodialysis. Should a minor's decision be respected?


A translocation in cattle and its association to polymorphisms in red cell antigens, transferrins and carbonic anhydrases.


Cytogenetical localization of the amylase region in Drosophila melanogaster by means of translocations.


Position-effect variegation for an isoamylase in Drosophila melanogaster.


Puffing pattern of 0-hour prepupae of Drosophila melanogaster.


Whole mount electron microscopy of core fibrils in salivary-gland chromosomes of Drosophila melanogaster.


H3-thymidine radioautography of salivary gland chromosomes treated with alkali-urea.


Population studies in northern Sweden. III. Variations of ABO and Rh blood group gene frequencies in time and space.


Interchromosomal effects of autosomal inversions in Drosophila melanogaster.


The effect of the Curly inversions on meiosis in Drosophila melanogaster. III. Interchromosomal effect of homozygous inversions.


Factors influencing the competitive ability of certain wild stocks of Drosophila.


The biochemical genetics of rudimentary mutants of Drosophila melanogaster. I. Aspartate carbamoyltransferase levels in complementing and non-complementing strains.


Whole mount electron microscopy of small chromomeres in salivary gland chromosomes of Drosophila melanogaster.


Whole mount electron microscopy of fibril-rings in alkali-urea treated salivary gland chromosomes of Drosophila melanogaster.


Female meiosis and embryonic mitosis in Drosophila melanogaster. I. Meiosis and fertilization.


Fitness and fitness components for a two-allele system in Drosophila melanogaster.


Exogenous acetylcholinesterase as tracer for extracellular pathways in the brain.


Histochemical demonstration of the intestinal hetero-beta-galactosidase (glucosidase).


Antimetabolites produced by microorganisms. XI. 1-(S)-hydroxy-2-(S,S)-valylamido-cyclobutane-1-acetic acid.


Editorial: Diabetes in the young.

Editorial: Diabetes in the young.


Completed chromosomes in thymine-requiring Bacillus subtilis spores. Origin:terminus genetic marker ratios (both purA: metB and purA:ilvA) were measured in extracts of spores of Bacillus subtilis strains W23 thy his and 168 thy. For strain W23 thy his, normalized to W23 spore deoxyribonucleic acid, both ratios were equal to unity and were consistent with the presence of only completed chromosomes in the spores. The same ratios in extracts of spores of 168 thy, normalized to strain 168 or the prototroph SB19, were abnormal, i.e., 2.26 +/- 0.10 and 0.71 +/- 0.06 for purA:metB and purA:ilvA, respectively. These values were unaffected by the extent of extraction of the spore deoxyribonucleic acid, the richness of the medium on which they are formed, and the thymine phenotype. The high ratio for purA:metB is in agreement with the results of earlier workers but, because of the low purA:ilvA ratio, cannot be explained simply by the presence of partially replicated chromosomes in spores of strain 168 thy. Furthermore, purA:leuA in such extracts is 1.01 +/- 0.06, consistent with the presence of only completed chromosomes. It is concluded that the abnormal origin:terminus marker ratios are only apparent and result from non-isogenicity between strains 168 thy and 168 in the metB thyB ilvA chromosome region introduced during construction of 168 thy by transformation of strain 168 with W23 thy deoxyribonucleic acid. It is concluded further that the chromosomes of strain 168 thy spores are in a completed form.


Purification and properties of 3-deoxy-D-arabionheptulosonic acid-7-phosphate synthetase (trp) from Escherichia coli. The 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase which is subject to regulation by tryptophan has been partially purified from a strain of Escherichia coli K-12, in which this is the only functional form of this enzyme activity, and from a similar strain possessing a feedback-resistant form of the enzyme. Maximal observed inhibition by tryptophan of the feedback-sensitive enzyme was 56%. There was no evidence for cooperativity in the saturation of the enzyme with tryptophan or E4P. The molecular weights of the feedback-sensitive and feedback-resistant forms of the enzyme were the same (52,000), and no change was detected in the molecular weight of the feedback-sensitve enzyme in the presence of tryptophan. The effect of tryptophan analogues was tested to determine the nature of the tryptophan binding site. Treatment with ethylenediaminetetraacetic acid removed 80% of the activity of the feedback-sensitive enzyme. This activity was restored upon the addition of Co(2+) or Mn(2+). Neither treatment with ethylenediaminetetraacetic acid nor addition of Co(2+) or Mn(2+) affected the activity of the feedback-resistant enzyme.


Lipopolysaccharide containing L-acofriose in the filamentous blue-green alga Anabaena variabilis. For the first time, an O-antigenic lipopolysaccharide (LPS) has been isolated from a filamentous blue-green alga (Anabaena variabilis). It was extractable with phenol-water, resulting in extraction of the bulk of the LPS into the phenol phase. The polysaccharide moiety of this LPS consists of l-rhamnose, its 3-O-methyl ether l-acofriose, d-mannose, d-glucose, and d-galactose. l-Glycero-d-mannoheptose and 2-keto-3-deoxyoctonate, the two characteristic sugar components of enteric LPS, and phosphate groups are absent from the A. variabilis O antigen. The only amino sugar present is d-glucosamine. Three hydroxy fatty acids were identified, namely, beta-hydroxymyristic, beta-hydroxypalmitic and beta-hydroxystearic acids, in addition to palmitic and unidentified fatty acid. The LPS of A. variabilis is localized in the outermost cell wall layer and behaves like a bacterial O antigen in serological tests. The passive hemagglutination yielded high titers with isolated LPS (pretreated by heat or by alkali) and rabbit antisera prepared against living or heat-killed cells. The position of the precipitation arcs after immunoelectrophoresis of the O antigen indicates the lack of charged groups. The water phase of the phenol-water extract contains, in high yield, a glucose polymer. It is serologically inactive as shown by the passive hemagglutination test and by agar-gel precipitation.


Activation of inactive nitrogenase by acid-treated component I. When Azotobacter vinelandii was derepressed for nitrogenase synthesis in a N-free medium containing tungstate instead of molybdate, an inactive component I was synthesized. Although this inactive component I could be activated in vivo upon addition of molybdate to the medium, it could not be activated in vitro when molybdate was added to the extracts. Activation occurred, however, when an acid-treated component I was added to extracts of cells derepressed in medium containing tungstate. Acid treatment completely abolished component I activity. Mutant strains UW45 and UW10 were unable to fix N(2). Both strains synthesized normal levels of component II but produced inactive component I. Acid-treated component I activated inactive component I in extracts of mutant strain UW45 but not mutant strain UW10. This activating factor could be obtained from N(2)-fixing Klebsiella pneumoniae, Clostridium pasteurianum, and Rhodospirillum rubrum.


Glycerolphosphate-containing cell wall polysaccharides from Streptococcus sanguis. Six glycerolphosphate-containing tetraheteroglycans, a, b-1, b-2, b-3, b-4, and b-5, have been purified from the formamide extracts of Streptococcus sanguis by alcohol and acetone precipitations, Sephadex G-75, and diethylaminoethyl-cellulose column chromatography. The polysaccharides were judged as at least 95% pure by analytical disc gel electrophoresis and immune double diffusion against rabbit antiserum. They were shown to be cell wall polysaccharides, since they formed a single band of identity in immune double diffusion with partially purified polysaccharide extracted from a purified cell wall preparation of S. sanguis. The polysaccharides were composed of l-rhamnose, d-glucose, and N-acetyl d-glucosamine in a similar molar ratio, but varied in their glycerol and phosphate contents. They exhibited four different mobilities in polyacrylamide disc gel electrophoresis at pH 8.9. When they were treated with formamide at 170 C for 20 min, the faster moving polysaccharide(s) yielded polysaccharides with mobilities corresponding to the other slower moving polysaccharides. These results indicate that the polysaccharides originated from the same cell wall polysaccharide and were produced as a result of breakage in the phosphodiester bonds during the formamide extraction procedure. A preliminary structural study shows that the terminal reducing sugar is l-rhamnose and that the glycerol moiety is probably linked to the polysaccharide through a phosphodiester bond.


Characterization of a bacteriophage-induced, host-specific lytic enzyme from lysates of Bacillus stearothermophilus infected with bacteriophage TP-8. Phage TP-8 lysates of Bacillus stearothermophilus 4S or 4S(8) contain lytic activity exhibiting two pH optima, one at pH 6.5 and the other at pH 7.5. Using a variety of fractionation procedures, the two lytic activities could not be separated. At pH 7.5 the lytic enzyme is an endopeptidase which hydrolyzes the l-alanyl-d-glutamyl linkage in the peptide subunits of the cell wall peptidoglycan and at pH 6.5 it exhibits N-acetylmuramidase activity. Endopeptidase activity is inhibited by NaCl and neither lytic activity was significantly affected by divalent cations or ethylenediaminetetraacetic acid. Crude lysates contain 2.5 to 3.0 times more endopeptidase activity than N-acetylmuramidase activity. The ratio of the two lytic activities (endopeptidase/N-acetylmuramidase) changes to 1.3 to 1.7 during the course of purification, to 1.0 after isoelectric focusing, and 3.9 and 6.00 after exposure for 2 h at 60 and 65 C, respectively. We conclude that the two lytic activities may be associated with a single protein or a lytic enzyme complex composed of two enzymes. Lytic activity at pH 7.5 is more effective in solubilizing cells or cell walls than the lytic activity at pH 6.5. LiCl extracts of 4S and 4S(8) cells contain lytic activity exhibiting endopeptidase activity at pH 7.5 and N-acetylmuramidase activity at pH 6.5. Lytic activity in these LiCl extracts also has a number of other properties in common with those in lysates of phage TP-8. We proposed that the lytic enzyme(s) are not coded for by the phage genome but are part of the host autolytic system.


Properties of thermosensitive extracellular alpha-amylases of Bacillus subtilis. Enzymological properties of four thermosensitive alpha-amylases (M3, M9, M18, and M20) brought by different mutation sites in alpha-amylase structural gene of Bacillus subtilis were compared with those of the parental alpha-amylase NA64. Two thermosensitive alpha-amylases (M9 and M20) were altered not only in their thermosensitivity but also in their immunological properties, catalytic properties, molecular weights determined by the gel filtration on a Bio-Gel P-100 column, and others. The other two thermosensitive alpha-amylases (M3 and M18) were altered only in their thermosensitivity.


Thermal death of temperature-sensitive lysyl- and tryptophanyl-transfer ribonucleic acid synthetase mutants of Bacillus subtilis: effect of culture medium and developmental stage. The growth of thermosensitive Bacillus subtilis lysyl- and tryptophanyl-transfer ribonucleic acid synthetase mutants (lysS1 and trypS1) (l-lysine:transfer ribonucleic acid [tRNA] ligase [AMP], EC 6.1.1.6; and l-tryptophan:tRNA ligase [AMP], EC 6.1.1.2) was terminated when exponential phase cells were shifted from 30 to 43 C in a rich medium. Under these conditions, the temperature-inhibited cells undergo thermal death; they rapidly lose their ability to form colonies at 30 C. Another lysyl-tRNA synthetase mutant (lysS2) is refractory to thermal death even though its growth is inhibited at 43 C. The thermal death response of the lysS1 mutant is affected by the stage of cell development. At periods in spore outgrowth and sporogenesis these cells become refractory to thermal death. The refractory state does not result from the production of an inhibitor, or from the degradation of an activator of thermal death. However, culture medium composition does modify the thermal death response. Rich media enhance the effect, and no thermal death occurs in the lysS1 strain grown in a minimal medium. Temperature-sensitive cells can grow in a lysine- (0.25 mM) or tryptophan- (0.25 mM) supplemented minimal medium at 43 C, but amino acid concentrations of 25 mM only transiently protect trypS1 and lysS1 cells from thermal death in a rich medium. Osmotic agents such as sucrose (0.5 M) and NaCl (0.34 M) completely prevent thermal death in the lysS1 strain, although growth is still arrested. On solid media, sucrose stabilized lysS1 cells can form colonies at the restrictive temperature, but neither sucrose (0.5 M) nor NaCl (0.34 M) stabilized the lysS1 enzyme in vitro. Chloramiphenicol increased the rate of thermal death of the lysS1 strain but decreased the thermal death response of the trypS1 mutant. Considering the nature of the enzyme defect in the lysS1 strain, the common genetic origin of the spore and vegetative lysyl-tRNA synthetase, and the protective effects exerted by lysine and osmotic agents, it is tentatively concluded that thermal death results from irreversible inactivation of the mutant gene product. According to this hypothesis, either the lysS1 enzyme is altered during sporogenesis or some physiological or structural aspect of this developmental phase can stabilize the mutant phenotype and thereby rescue cells from thermal death.


Pyrolytic biocarbon materials.

Pyrolytic biocarbon materials.


Extracellular enzyme from Myxobacter AL-1 that exhibits both beta-1,4-glucanase and chitosanase activites. An enzyme that has both beta-1,4-glucanase and chitosanase activities is characterized. Evidence for homogeneity was obtained from electrophoresis and sedimentation velocity studies; only one N-terminal amino acid, valine, was found. Results of denaturation studies showed that beta-1,4-glucanase and chitosanase activities decreased at equal rates. With carboxymethylcellulose as the substrate, a K(m) of 1.68 g of carboxymethylcellulose per liter of solution and a V(max) of 2.20 x 10(-9) mol/min were found. With chitosan (the beta-1,4-polymer of glucosamine) as the substrate, a K(m) of 0.30 g of chitosan per liter of solution and a V(max) of 0.75 x 10(-9) mol/min were found. A pH optimum of 5.0 was found for beta-1,4-glucanase activity, and pH optima of 5.0 and 6.8 were found for chitosanase activity. beta-1,4-Glucanase activity had a temperature optimum of 38 C, and chitosanase activity had a temperature optimum of 70 C. Chitosan stabilized both enzyme activities at 70 C. Cellotriose was the smallest polymer capable of hydrolysis. Glucosamine was released by action of the enzyme upon cell wall preparations of several fungi.


In vivo kinetics of nitrogenase formation in Clostridium pasteurianum. Clostridium pasteurianum exhibits diauxic growth when grown in the presence of both NH(3) and N(2); no nitrogenase activity or formation was detected either serologically or by activity during growth on NH(3). During the 60-min lag that ensued after NH(3) was consumed and before growth resumed, molybdoferredoxin and azoferredoxin were first detected by activity measurements and serologically at 25 and 40 min, respectively. With the use of rifampin and dactinomycin, it was found that azoferredoxin messenger ribonucleic acid was initiated between 25 and 30 min after the inception of the lag and was completed by 38 min. An explanation of these results and their relation to possible models for the regulation of nitrogenase is given.


The components of "affectionless psychopathy in institutionalized children.


Scrapie--a personal view.

Scrapie--a personal view.


Host-virus relationship with special reference to Newcastle disease and serum hepatitis.


Amyotrophic lateral sclerosis, Parkinson's disease, and the amyotrophic lateral sclerosis-Parkinsonism-dementia complex on Guam: a review and summary of attempts to demonstrate infection as the aetiology.


Membrane hypothesis of scrapie.

Membrane hypothesis of scrapie.


The nature of the scrapie agent.

The nature of the scrapie agent.


Isolation and characterization of the subacute spongiform virus encephalopathies of man: kuru and Creutzfeldt-Jakob disease.


Response of whole-body irradiated mice to inoculation of Theileria parva-infected bovine lymphoid cells.


Three cases of suspected mammary neoplasia in non-human primates.


Erythrocyte losses from pigs with experimental Trichuris suis infections measured with a whole-body counter.


The ectopic mandibular second molar.

The ectopic mandibular second molar.


A new method of preparation of specifically purified anti-TNP antibodies.


Antibodies to endotoxin from Vibrio cholerae measured by bactericidal and indirect hemagglutination tests. Differences in immunoglobulin classes and specificity.


Isoelectric focusing of rabbit IgM hemolysin: heterogeneity with respect to charge and function.


Haemolytic assay of bovine serum complement.


Polychlorobiphenyl toxicity and nutrition. II. PCB toxicity and vitamin A (2).


Proceedings: The release of thyrotrophin in response to thyrotrophin releasing hormone (TRH) in the pregnant ewe, lamb foetus and neonatal lamb.


Proceedings: Dorsal horn neurons excited by cutaneous cold receptors in primates.


Cancers of the larynx and hypopharynx. II. Laryngeal cartilage behaviour.


Focal EEG in post-traumatic mild coma. Follow-up study on unoperated patients.


The relationship between listericidal and mycobacteriostatic activity in BCG-vaccinated mice.


Treatment of juvenile rheumatoid arthritis -- a world survey.


Studies on the live attenuated rubella virus vaccine. II. Research concerning attenuation of "Takahashi strain" isolated in Japan.


Interaction between glucocorticoids and TSH secretion.


Immune response in patients with autoimmune thrombocytopenia and autoimmune haemolytic anaemia receiving azathioprine.


Clinical observations on therapeutic applications of thyrotropin-releasing hormone (TRH).


Two minutes with diabetes.

Two minutes with diabetes.


Functional diversity within the rudimentary locus of Drosophila melanogaster. The rudimentary locus of Drosophila melanogaster is shown to be at least bifunctional. Mutants in different regions of the locus have either no CPSase or no ATCase activity; some mutants lack both activities. The results are discussed in correlation with the complementation and genetic map of the locus.


A meiotic effect of a mutator gene in Drosophila melanogaster.


Vulture retina enzyme distribution and function.


Effect of eight tetracyclines on growth and lipase formation of Staphylococcus aureus.


Immunity to influenza in ferrets. IX. Delayed hypersensitivity following infection or immunization with A2/Hong Kong virus.


On the cleavage of starch and disaccharides in the human oral cavity.


Surface properties of cells of gentamicin-sensitive and gentamicin-resistant strains of Pseudomonas aeruginosa.


Influence of growth conditions on the formic: acetic acid ratio in Escherichia coli and Streptococcus faecalis.


The anti-proteins in Salmonella monofactor sera.


Autonomic and behavioral temperature regulation. Unilateral vs bilateral preoptic thermal stimulation.


Ryle's tube. John Ryle (1889-1950).

Ryle's tube. John Ryle (1889-1950).


Repeat prescription cards.

Repeat prescription cards.


A case of paratyphoid fever accidentally treated with amoxycillin. (Case report).


The use of intestinal markers to measure digestive function in ruminants.


Proceedings: Linolenic acid deprivation in Capuchin monkeys.


Proceedings: Lipid composition of human milk: comparative studies on African and European mothers.


Immunodepressive effects of combination chemotherapy with N-diazoacetylglycine amide, L-asparaginase, and cortisone, in mice.


Central nervous system toxic manifestations of sodium cyanate.


Glycogen in the central nervous system.

Glycogen in the central nervous system.


New aspects of malnutrition in Jakarta.

New aspects of malnutrition in Jakarta.


Reversal by Pseudomonas aeruginosa of rifamycin SV inhibition of Staphylococcus aureus in vitro and in vivo.


Letter: Enhancement of E-rosettes formation after treatment of lymphocytes with papain.


Increased phosphorylation of nuclear phosphoproteins in precancerous liver.


Radial immunoassay of erythrocyte carbonic anhydrase enzymes: a screening procedure to detect megaloblastic erythropoiesis.


Experimental bases of chronic lung diseases.


Cold induced retraction of reptilase clots.


Platelet factor 4 (PF-4). An electroimmuno assay for PF-4 in human plasma.


Role of some elements on the enzymatic transformation of cortisol with Bacillus cereus.


Human secretory component. II. Physicochemical characterization of free secretory component purified from colostrum.


IgM reassociation in Vitro: no influence of J chain on the amount of polymers.


Antibody-dependent cell-mediated cytotoxicity in the mouse. I. Surface characteristics of an effecter cell.


Comparative study of antibody-dependent and direct lymphocyte-mediated cytotoxicity in vitro after alloimmunization in the human. II. Chemical inhibitors.


N-terminal amino acid sequence of amyloid fibril protein AR, prototype of a new lambda-variable subgroup, V lambda V.


Surface IgD in immunoproliferative disorders.


A monoclonal IgG protein with antibody-like activity for transferrin and with kappa chains of an unusual molecular size.


Comparison of Fch and Fc fragments of IgG3: evidence of an intra-chain S-S bridge in the hinge of gamma3 chains.


Pathophysiology of Cholelithiasis.

Pathophysiology of Cholelithiasis.


The tuberculosis morbidity among pathologists in Finland.


Experimental chemotherapy of schistosomiasis. VII. Laboratory and clinical trials with sodium antimony dimethylcysteine tartrate (NaP).


The relationship between protein-calorie malnutrition and trichinosis: 1. Studies on the number of intestinal worms and muscular larvae in rats fed low and high protein diets.


Cardiac malformations and other effects due to insecticides in embryos of the killifish, Fundulus heteroclitus.


The effects of moderate hypoxia and moderate hypoxia plus hypercapnea on cardiac development in chick embryos.


Properties of soluble fibrin polymers encountered in thrombotic states.


Inactivation mechanism of tyrosinase.

Inactivation mechanism of tyrosinase.


B lymphocytes bearing immunoglobulins in multiple sclerosis.


Cross-neutralization by tiger snake (Notechis scutatus) antivenene and sea snake (Enhydrina schistosa) antivenene against several sea snake venoms.


Studies on Egyptian Cerastes cerastes antivenin.


The mesosome--a clue to the evolution of the plasma membrane.


Susceptibility of a new world monkey (Aotus trivirgatus) to an old world simian malarial parasite (Plasmodium knowlesi).


Letter: A skin test for the diagnosis of Chagas's disease.


Rickettsioses in Australia: isolation of Rickettsia tsutsugamushi and R. australis from naturally infected arthropods.


Letter: Serology of human sacosporidiosis.


Orthopaedic tuberculosis in the tropics.


Diabetes in Kenya.

Diabetes in Kenya.


Serum immunoglobulin patterns in South African population groups.


Folate levels in protein malnourished Nigerian children.


Human immunity to gonococci: studies of opsonization by sera of prostitutes and nuns.


A cytophotometric study of the DNA distribution in Ehrlich ascites tumour populations at different stages of development.


Cytogenetic studies of ectopic pregnancies.


Influence of X-irradiation on the different stages of the cell cycle in regenerating rat liver.


The diagnostic value of the DNA content of fine needle biopsies of the thyroid gland.


Cultivation and survival studies of Neisseria gonorrhoeae in a human diploid cell strain. Neisseria gonorrhoeae was cultivated in a human diploid cell strain (WI-38). Eighty percent of the cultures contained viable gonococci for at least 4 m at 36°C, as evidenced by subculture to brain heart infusion broth. Monthly subcultures of bacteria could be made to fresh WI-38 cultures for at least 11 monthly passages with a 69% survival rate. The identity of gonococci was confirmed by morphology, gram staining, oxidase testing and fermentation reactions. Viability in brain heart infusion broth, minimum essential medium (Eagle), and WI-38 spent fluid was of much shorter duration. The organisms grown in WI-38 cultures appeared to orient largely in the vicinity of the WI-38 cells as well as within the cytoplasm of the cells.


Bacterial density in operation wounds.

Bacterial density in operation wounds.


Antisepsis of the operation site with aqueous cetrimide/chlorhexidine and chlorhexidine in alcohol.


Aseptic barriers of plastic to prevent bacterial contamination of operation wounds.


Experimental extracorporeal liver perfusion in vivo with daunomycin and 5-fluoro-uracil.


Absorption of vitamin B12 in rats with jejuno-ileal transposition.


Duodenal diverticulum with intermittent biliary stasis.


Poly(A)-containing RNA molecules in electrophoretically separated fractions of rapidly labeled nuclear RNA from unstimulated and PHA-stimulated human lymphocytes.


Site of action of desferrioxamine in removing iron in normal and pathological conditions.


Origin, morphologic and functional characteristics of a new lymphoid cell type in irradiated mouse bone marrow.


The gamma-chain in a Ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin.


Homozygous beta delta-thalassaemia. Description of a case and review of the literature.


Methods for measurement of the cerebral blood flow.


Some properties of proteolytic enzymes in human saliva.


Gas chromatography of bacterial whole cell methanolysates; IV. A procedure for fractionation and identification of fatty acids and monosaccharides of cellular structures.


A histochemical and electron microscopical study of so-called intravenous fat pigment.


Three autopsy cases of so-called neonatal necrotizing enterocolitis.


Gas chromatography of bacterial whole cell methanolysates; V. Fatty acid composition of Neisseriae and Moraxellae.


Protein A production in different strains of Staphylococcus aureus under varied growth conditions.


Activities of some enzymes concerning pyruvate metabolism in Neisseria.


Purine metabolism in Neisseria meningitidis. 2. Utilization of exogenous adenosine, guanosine and inosine.


Immunological comparison of NADP-dependent glutamate dehydrogenase and malate dehydrogenase in genus Neisseria.


Acetylsalicylic acid intolerance.

Acetylsalicylic acid intolerance.


Epilepsy in the elderly.

Epilepsy in the elderly. Among 50 geriatric inpatients (average age 79) with late-onset epilepsy (average duration two years), 28 had grand mal attacks, 12 had focal attacks, seven had both. None had petit mal, confirming its rarity in the elderly. The epilepsy followed cerebrovascular disease (usually with hemiplegia) in 21 patients (8 per cent of all our patients with hemiplegia in the two-year study period developed epilepsy). Associated conditions included dementia in seven; and cerebral tumours (usually metastases) in five. This latter group survived less than two months on average from the onset of their attacks. The majority of patients (42 out of 50) were unfit for full neurological investigation; and the dangers of some procedures in the elderly are stressed.


Research in Coccidia and other Apicomplexa. A progress report.


Letter: Hyperalimentation procedures.

Letter: Hyperalimentation procedures.


Current drug therapy--antiepilepsy agents.


The adult respiratory distress syndrome.


Membrane-peptidoglycan association in the in vitro biosynthesis of the peptidoglycan of Micrococcus luteus.


Disodium cromoglycate in the treatment of bronchial asthma. Study of 479 cases during ten months.


Phenotypic expression of an envC-division mutant of Escherichia coli K12.


A change in cell diameter associated with an outer membrane lesion in a temperature-sensitive cell division mutant of Salmonella typhi-murium.


The role of divalent cations in the rigid layer of morphological and conditional mutant of Klebsiella pneumoniae Mir M7.


Functional disorders of the oesophagus. Roentgenological, cineradiographic and manometric study.


Behavioral responses to insect pheromones.


Insect nutrition: current developments and metabolic implications.


Neuro-hormonal control of sexual behavior in insects.


Propylene oxide as sterilizing agent.

Propylene oxide as sterilizing agent. Liquid propylene oxide added to a variety of disinfectant solutions resulted in a significant reduction of the bacterial spore content of these solutions.


Influence of insecticide exposure on the in vivo and in vitro metabolic activity of rats.


Gold therapy in rheumatoid arthritis.

Gold therapy in rheumatoid arthritis.


Is Sarcocystis tenella two species.

Is Sarcocystis tenella two species.


Alcohol dehydrogenase in Drosophila melanogaster: activity variation in natural populations.


Immunological relationships and post-translational modification of human salivary amylase (Amy) and pancreatic amylase (Amy) isozymes.


A method for determining diamine oxidase (histaminase) in biological fluids.


A method for assaying hepatic morphine UDP-glucuronyl transferase.


Present status of treatment of the mucopolysaccharidoses.


Cross pathway regulation of tyrosine and histidine synthesis in Bacillus subtilis. Biochemical, genetic, and transfer RNA studies.


Clinical heterogeneity in mucopolysaccharidosis. II. Evidence for epistasis.


Stickler syndrome. Presenting as a syndrome of cleft palate, myopia and blindness inherited as a dominant trait.


Case report. Case 2 (mucolipidosis III).


Arousal effects on unit responsiveness to vocalizations in squirrel monkey auditory cortex.


Behavior in Drosophila melanogaster. A geneticist's view.


Fluorescence-activated cell sorting of human T and B lymphocytes. I. Direct evidence that lymphocytes with a high density of membrane-bound immunoglobulin are precursors of plasmacytes.


Cytoplasmic membrane changes in conjugating Tetrahymena.


Serological testing in malaria.

Serological testing in malaria. The main purpose of this paper is to evaluate, in a critical manner, various serological tests with general emphasis on their value in the epidemiological assessment of malaria. Several tests have been employed in the past. However, the present memorandum will deal only with the methods that have been widely used recently-i.e., indirect immunofluorescence (IFA), passive haemagglutination (IHA), and gel-diffusion. The three immunoglobulins most commonly involved in these tests are IgG, IgM, and-to a lesser extent-IgA.


Macrophage migration from an agarose droplet: a micromethod for assay of delayed hypersensitivity in the mouse.


Retinal projections traced with thaw-mount autoradiography and multiple injections of tritiated precursor or precursor cocktail.


Distribution of plasma proteins and hyaluronic acid in synovial fluid and serum of human subjects in hydarthrosis.


Comparison of serum vitamin B12 determination by two isotope dilution methods and by Euglena assay, with special reference to low values.


The use of merthiolate for TBG-blocking in the radioimmunoassay of triiodothyronine.


Letter: Comments on the article, "Chlorinated hydrocarbons in the Sargasso Sea atmosphere and surface water.


In vitro inhibition of succinic dehydrogenase by manganese and its reversal by chelating agents.


Relation between pituitary responsiveness to thyrotropin releasing hormone and serum thyroid hormones in hyperthyroidism.


Effect of depletion of serum calcium by EGTA on canine pancreatic secretion induced by dopamine and by secretin.


Test for mycoplasma on tissue culture vaccines.


Experiences in the use of biological indicators in ethylene oxide sterilization.


Microbacterium lacticum, troublemaker in blood fractions.


Application of laminar flow (clean work bench) for purifying the atmosphere.


Comparative studies on culture media used for sterility testing.


Functionally balanced nomograms for reading the interdependence of PO2 and HbO2 in some laboratory animals.


Mechanism of the action of some antithyroid substances: influence of methylmercaptoimidazole on the enzyme activities in the tissues of thyroidectomised guinea-pigs with suppressed secretion of the thyrotropic hormone.


Some monosaccharide oximes as cholinesterase reactivators following the loading of white rats with parathion.


The effects of some protective media during thyroid gland preservation in liquid nitrogen at--196 degrees C.


An x-ray investigation of the development of the frontal sinuses in children.


Urine excretion of vit. B12 58Co in patients with hepatic cirrhosis previously treated with therapeutic dose- of non-radioactive vit. B12.


The synthesis of 113m-In-complex for the scintigraphic study of the kidneys.


The ectotympanic bone and origin of higher primates.


Changes in facial color associated with pregnancy in patas monkeys. (With 1 color plate).


Letter: Effect of dosing technique on absorption of carbaryl.


The effect of polychlorinated biphenyls on rat reproduction.


Complexes in plasma between light chain kappa immunoglobulins and alpha 1-antitrypsin respectively prealbumin.


Studies on cryoprecipitation: covalent structure of a human IgG cryoglobulin and its gelation characteristics.


A 22S cryomacroglobulin with antibody-like activity. I. Physico-chemical characterization and modification of its cryoproperties.


Quantitation of hemoglobins by immunodiffusion: specific antibodies to hemoglobins A1, S and F.


The identification of IgE in human head hair.


Carbohydrate composition and complement fixation of human monoclonal IgG.


An improved method for preparation of stable antigen coupled erythrocytes for passive hemolysis.


Chemical analyses of cryoglobulins.

Chemical analyses of cryoglobulins.


Rabbit immunoglobulin lambda chains: isolation and amino acid sequence of cysteine-containing peptides.


Immunochemical studies of human red cell membrane proteins excreted in normal urine.


Preferential allotypic expression of anti-hapten response in first and second generation heterozygous rabbits of al,3 allotype.


Free and bound carcinoembryonic antigen in neoplasms and in normal adult and fetal tissue.


Development of a radioimmunoassay for luteotropin releasing hormone (LRH) and thyrotropin releasing hormone (TRH).


The NH2-terminal amino acid sequence of a kappa and a lambda Bence-Jones cryoglobulin.


The calculation of antigen concentrations in the single radial immunodiffusion.


An antiglobulin reagent labelled with colloidal gold for use in electron microscopy.


Immunoglobulin synthesis in tumors of human lymphoid origin serially transplantable in the neonatal Syrian hamster.


Agglutination of normal and neoplastic human cells by Concanavalin A and Ricinus communis agglutinin.


Lactose synthetase induction by hormones in normal and tumorous GR mouse mammary tissue.


Random chromosome changes following SA7 transformation of Syrian hamster cells.


Herpesvirus ateles: properties of an oncogenic herpesvirus isolated from circulating lymphocytes of spider monkeys (Ateles sp.).


Effects of sublethal x-ray doses on the number of ovarioles in Drosophila melanogaster populations.


Occurrence of tubercle bacilli in urine or menstrual blood in patients at final examination before intended deletion from the dispensary register.


Calf serum content of cell culture grown viral vaccines and possibilities for its reduction.


Report of an informal meeting of manufacturers and the control laboratory on influenza vaccine. Held at the National Institute for Biological Standards and Control on Monday, 17 December 1973.


Preservation of sera by means of paper discs.


Determination of diphtheria antitoxin in guinea-pig sera by the Jensen and tissue-culture methods.


Baseline karyologic values for primary rhesus and African green monkey cell cultures.


von Recklinghausen's disease presenting as the neurofibrosarcoma of the female breast.


Educational planning for long-term care administration.


Guest editorial: Long term care--a top health priority.


Editorial: The role of the administrator in the long term care facility.


Guest editorial: Education for the profession--an AUPHA update.


Evaluating the organization and management of the long term care program.


Editorial: Regulation of long term care.


Guest editorial: PSRO review of long term care.


Autoimmune diseases and thalidomide. II. Adjuvant disease, experimental allergic encephalomyelitis and experimental allergic neuritis of the rat.


Patient care assessment: a managerial strategy.


Aleutian disease--1974.

Aleutian disease--1974.


Acute infectious agent arthritis (IAA): a detailed comparison of proved gonococcal and other blood-borne bacterial arthritis.


Social and cultural aspects of hospitalised malnourished children in Jordan.


Cell mediated immunity in protein-calorie malnutrition.


Pathological observations of feline mast cell tumor.


Mechanism of action of antitumor agents on bacteria. II. Effect of acetyl-kidamycin on nucleic acids.


Guest editorial: Physician services and long term care institutions.


On the possibility of in vitro transformation of human peripheral blood lymphocytes by chemical carcinogens.


Disseminated herpes simplex in untreated multiple myeloma. Paradox of present concepts of immune defects. A patient with disseminated herpes simplex virus infection, documented by direct immunofluorescence, and untreated multiple myeloma with abnormal immunoglobulins is presented. Reports of infections with intracellular pathogens in myeloma patients are rare, whereas pyogenic infections have been amply documented. Partly in consequence of this, the untreated disease has been thought of as a relatively pure defect in humoral immunity. Review of present knowledge suggests that cell-mediated immunity is of paramount importance in combatting and containing infection with this virus. Thus, immune defects in multiple myeloma, and its infectious complications, may be more complex than appreciated by current concepts of this disease based on previously reported cases.


Effects of insulin and growth hormone on protein synthesis in newborn offspring of protein-energy malnourished rabbits.


The effects of trace elements and ethylenediaminetetraacetic acid on the survival of chicks inoculated with Salmonella gallinarum.


Enzyme derivatives containing reactive groups. II. Immobilization of alpha-amylase on human erythrocytes using 5,5 dithiobis (2 nitro benzoic acid) and M-maleimidobenzoic acid adducts.


Action of 5-hydroxytryptamine, histamine and methergoline on phagocytosis.


Synergistic lethal action of alkylating agents and sodium pentobarbital in the mouse.


Recent advances in parenteral alimentation of infants.


Simultaneous insulin immunoassay in sera, heparin-, and EDTA-plasma.


Acid-base status in nonketotic diabetics.


Cell agglutinating activities of some enteric bacteria and effects of various factors on bacteria-tumor cell agglutination.


Anti-Trypanosoma cruzi IgM antibodies as serological evidence of recent infection.


A demonstration of the role of the renal erythropoietic factor in erythropoietin production.


Letter: Effect of diethylcarbamazine on the filarial skin test.


Letter: Mebendazole--ineffective against Onchocerca volvulus.


Incidence of sarcosporidiosis in sheep in Iran.


Role of Australia (Au) antigen in chronic liver disease in infancy and childhood.


Sulfate reabsorption by the urinary bladder of Bufo marinus.


Foetal medicine.

Foetal medicine.


A comparative golgi sutdy of the neocortex in insectivores and rodents.


Severe neonatal jaundice. Analysis of possible associated factors in infants from Accra.


Clinical experience with dihydroergocristine-reserpine-clopamide combination (brinerdin) in Ghanaian hypertensives.


Remission of severe diabetes mellitus in a Ghanaian.


A simple laboratory diagnosis of meningitis: the causative organism and therapy.


Myoglobin in homozygous beta-thalassaemia.


High transfusion regime in the management of reproductive wastage and maternal complications of pregnancy  in thalassaemia major.


Increased capillary permeability in haemophilia and afibrinogenaemia.


Antiglobulin antibodies and anticomplementary factors in hepatitis b antigenaemia.


Myeloma in a case of hodgkin's disease.

Myeloma in a case of hodgkin's disease.


Thrombotic thrombocytopenic purpura with autoimmune pancytopenia.


Distribution of lipase (EC 3.1.1.3) in the digestive system of two teleost fishes.


The localization of alkaline phosphatase activity in the rat small intestinal epithelium after fat and protein feeding.


Localisation of alkaline phosphatase activity in the ovary of the percoid teleost fish Nandus.


Histochemical localization of esterase and lipase in the digestive system of two teleost fishes.


Location of steroid hormone production in the ovary of Trachurus mediterraneus.


Repair of the post-extraction sockets in marmosets (Callithrix jacchus).


Treatment of biliary atresia.

Treatment of biliary atresia.


Surgical approach to nutritional problems.


Parrallel enzymatic changes detectable in cancer and schizophrenic patients as a possible result of environmental stimulation.


Certain experimentally demonstrated connections of the chief sensory trigeminal nucleus in the squirrel monkey Saimiri sciureus.


Immunoglobulin biosynthesis and its control.


Rabbit heavy chain allotypes: are they subjected to selective pressure?


Choline incorporation into phospholipids by microsomal fractions from L5178Y lymphoma.


Transport of folate compounds into Lactobacillus Casei.


Changes in serotonin (5-HT) concentrations in brain tissue of rats with adjuvant-induced polyarthritis.


Optimal conditions for the hydrolysis of seclazone by rat hepatic microsomes.


Effects of bacterial cardio-stimulating substance on cardiac metabolism in dogs.


Cytochemical changes in conjugants and exconjugants of Blepharisma intermedium.


Peribiliary portal system in the monkey liver as evidenced by the injection replica scanning electron microscope method.


Acquired diverticula of the vermiform appendix.


Burns and the use of silver sulphadiazine.


The successful conservative management of high-output entero-cutaneous fistulae.


Some unusual aspects of clefts of the lip.


The pathogenesis of muscular dystrophy: a review.


Genetics of French-Canadians.

Genetics of French-Canadians.


Genetic marker systems in Philippine Negritos.


Hip arthrography in the epiphyseal dysplasias.


Treatment of mucopolysaccharidoses.

Treatment of mucopolysaccharidoses.


Beta-glucuronidase deficiency (mucopolysaccharidosis type VII).


Comments on the plasma treatment of the mucopolysaccharidoses.


Histologic studies in the chondrodystrophies.


A possible etiologic mechanism for fibrodysplasia ossificans progressiva.


Ultrastructure of cartilage in chondrodystrophies.


Fine structure of skeletal dysplasia as seen in pseudoachondroplastic spondyloepiphyseal dysplasia and asphyxiating thoracic dystrophy.


Pseudoachondroplastic dysplasia: pathodynamics and management.


Spondyloepiphyseal dysplasia-unclassified type.


Spondyloepiphyseal dysplasia congenita.

Spondyloepiphyseal dysplasia congenita.


Spondyloepiphyseal dysplasia tarda, X-linked form.


Unclassified short stature, probably mild spondyloepiphyseal dysplasia.


Distinctive spondyloepiphyseal dysplasia in father and three children.


Unclassified short stature, possibly spondyloepiphyseal dysplasia, possibly multiple epiphyseal dysplasia, in father and daughter.


Spondylometaphyseal dysplasia (Brazilian type).


Pleomorphism of hip disease in a large kinship with spondylo- and multiple epiphyseal dysplasia.


Simultaneous parastremmatic dwarfism and osteogenesis imperfecta.


Mucopolysaccharidosis: possible Hurler/Scheie genetic compound (MPS I-H/S).


The Morquio syndrome (MPS IV).

The Morquio syndrome (MPS IV).


Morquio syndrome in a woman with two normal children.


Two brothers with nonkeratan-sulfate-excreting Morquio syndrome.


Mucolipidosis II (I-cell disease).

Mucolipidosis II (I-cell disease).


Mucolipidosis, probably a new variant with joint deformity and peripheral nerve dysfunction.


Proximal focal femoral deficiency (familial).


Fibrodysplasia ossificans progressiva (FOP) treated with diphosphonate.


Blood viscosity in healthy men, measured in rhombospheroid viscometer on EDTA blood. A comparison with the cone-in-cone viscometer data and those of Copley.


A scale of disability and prognosis in long-term mental illness.


Collateral inhibition in the sensorimotor cortex of the cat and the squirrel monkey - its role in control of neuronal discharges.


Effects of ablating the striate cortex on a successive pattern discrimination:further study of the visual system in the tree shrew (Tupaia glis).


Cerebral hemisphere: primary layering and inner structural interrelationships.


Concurrent measurement of left ventricular dPdtmax, isometric contractile force and cardiac loading in the intact monkey.


Possible role of cerebellar circuits in parkinsonian symptoms.


Interpretation of hyperlipidemias.

Interpretation of hyperlipidemias.


Nervous mechanisms involved in experimentally induced extrapyramidal disturbances.


Prindolol (Visken) and alprenolol (Aptin) in angina pectoris: a comparative clinical study with special reference to ergometer working capacity tests.


Triazolam: a sleep laboratory study of a new benzodiazepine hypnotic.


A multicentric trial of a new synthetic antibacterial in urinary infections.


Sex-chromosome pairing and male fertility.


Toxicodynamics of aroclor 1254 in the male rat.


Cytostatic activity of chlamydocin, a rapidly inactivated cyclic tetrapeptide.


The haematopoietic stem cell in Rauscher virus-induced erythroblastosis of BALB/c mice.


In vitro drug selection in antineoplastic chemotherapy.


Assessment of the health and nutritional standards of infants and preschool children in high density Cairo community.


Early abortion in a family planning clinic. The successful integration of sessions for very early abortion in the Planned Parenthood Clinic of San Francisco is described.  Abortion sessions replaced 2 one- half days of contraceptive clinics per week.  Flexible Karman cannulas and foot, or electrically-operated vacuum pumps were used.  Routine testing for RhD antibody and gonorrhea were done at each abortion.  560 women were aborted during the year and 4 had repeat abortion.  Problems encountered were 1.8% failed abortion requiring repeat suction, 1.6% bleeding heavier than a menstrual period, 3% infection in the uterus or surrounding tissues, and 1 ecotopic pregnancy.  The abortion service in the Clinic was well accepted by patients, staff, the medical community, and the community at large.


Fat absorption in protein-calorie malnutrition.


Xylose absorption in protein-calorie malnutrition.


Effectiveness of Rh prophylaxis.

Effectiveness of Rh prophylaxis.


HL-A phenotype and anti-RhO(D) immunization.


Preventing the incompatible blood transfusion.


Immunization of RhO(D)-negative secundigravidae whose first pregnancy was terminated by induced abortion.


Some obvious problems of a developing country.


Proceedings: Degradation of thyrotropin-releasing hormone (TRH) by serum and hypothalamic tissue and its inhibition by analogues of TRH.


Proceedings: Metabolic significance of the two interconvertible forms of M2-type pyruvate kinase.


Proceedings: Fractionation of chromatin in sucrose gradients.


Proceedings: Immunological relatedness of human and porcine growth hormones.


Proceedings: Induction of alpha-glucosidase during the cell cycle of Myxobacter Al-1.


Proceedings: The effect of glucose concentration on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthase in isolated rat hepatocytes.


Proceedings: Epinephrine binding by rat liver plasma membranes. Effect of guanyl nucleotides and EDTA.


Proceedings: The defect in Maroteaux-Lamy disease (mucopolysaccharidosis VI, subtype A): deficiency of N-acetylgalactosamine-4-sulfatase.


Proceedings: Aspects of regulation of the pathways for D-glucose 6-phosphate, D-galactose, and L-arabinose in Pseudomonas fluorescens.


[Preservation of chicken and quinea-pig erthrocytes for the haemagglutination test by "Newcastle disease virus": electron microscopic studies].


Proceedings: Structural features determining the antibiotic potencies against Bacillus subtilis of the membrane active hop bitter resins.


Proceedings: The complete amino acid sequence of a rat kappa-light chain.


Proceedings: Inhibition of fatty acid biosynthesis with cerulenin and its effects on citrate-Mg-2 transport and macromolecular syntheses in Bacillus subtilis.


DNA replication continued in isolated nuclei of synchronously growing Physarum polycephalum.


Human cyclopia with assiciated anomalies.


Distribution of ABO and Rh blood groups among the tibetans.


Morphology of the primate nasopharynx.

Morphology of the primate nasopharynx.


The role of cartilage in long bone growth: a reappraisal.


Studies on the biosynthesis of beta-lactam antibiotics. (part)I. Stereo-specific syntheses of (2RS,3S)-[4,4,4-2-H3]-, (2RS,3S)-[4-3-H]-,(RS,3R)- [4-3-H]-, and (2RS,3S)-[4-13C]-valine. Incorporation of (2RS,3S)-[4-13C]- valine into penicillin V.


3-Hydroxyaflatoxin B1: a new metabolite of in vitro aflatoxin B1 metabolism by Vervet monkey (Cercopithecus aethiops) liver.


Studies of common baldness in the stump-tailed macaque. V. Regional difference of testosterone metabolites in the hair follicles.


The synthesis, assembly, and secretion of immunoglobulin: a biochemical and genetic approach.


Problems and pitfalls in blood grouping tests for non-parentage.  IV. Qualifications of experts.


Ultrastructural studies of the dying-back process.  II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseases axons.


A histological comparison of the giant cells in the central giant cell granuloma of the jaws and the giant cell tumor of long bone. A histological comparison has been made of the giant cells in 10 cases which had been diagnosed as central giant cell granuloma of the jaws and 10 cases diagnosed as giant cell tumor of long bone. The numbers of nuclei in each of 50 giant cells were counted in the 20 lesions. The giant cells were measured in order to compare their sizes in the respective lesions. It was found that the giant cells of the jaw lesions contained significantly fewer nuclei than those of the lesions in other bones. Secondly it was found that cells in the lesions of long bone have significantly larger dimensions than those in the jaw lesions. There was, however, an area of overlap. It was concluded that these data supported the view that giant cell tumor and giant cell granuloma are distinct entities. Some giant cell lesions of long bones are, however, morphologically indistinguishable from lesions of the jaws; and conversely giant cell lesions of the jaws are indistinguishable from some giant cell lesions of the long bones. It seems possible, therefore, that some jaw lesions are giant cell tumors and that some giant cell lesions outside the jaws are giant cell granulomas.


Tissue reactions to two fissure sealant resina. Specimens of polymerized and unpolymerized Nuva-Seal and Alpha-Seal were implanted subcutaneously on polythene rods. Polymerized specimens caused only slightly greater reaction than controls over intervals of from 2 days to 1 year. Unpolymerized specimens caused necrosis, marked inflammatory cell infiltration and granulation tissue formation for up to 1 week but were similar to the controls at 1 year. No reaction to unpolymerized resin painted on the oral mucosa was observed.


Leukocyte mediated cytotoxicity of chemically induced rat salivary gland neoplasms. Chemically induced tumors of the rat submaxillary glands were tested for the presence of tumor antigens by in vitro leukocyte mediated cytotoxicity assays. Since it has been reported that the saliva of humans with oral cancer contains markedly elevated levels of secretory antibody, the rats' saliva specimens were also tested for blocking and/or potentiating "antibody" activity. The results indicate that saliva from tumor-bearing animals potentiated tumor cell killing if either the tumor cells or leukocytes were pretreated. The effect was much more marked when tumor cells were pretreated. Furthermore, the addition of saliva to tumor cells imparted an immunologic cross reactivity which was not present with untreated tumor cells. Control saliva occasionally produced a similar effect, but not as consistently or with the potency of saliva from tumor-bearing animals. Heat inactivation did not abrogate this potentiation. It is inferred that this may indicate a new system of immunologic surveillance, i.e. arming or potentiation of leukocytes by soluble tumor antigens in glandular secretions.


In vivo calcification of implanted bone cells. Bone cells raised in cell culture from the osteogenic cells of newborn rat calvaria were reimplanted in the same species of animals from which the cells were derived. The cells were sealed in Teflon rings containing Millipore filters over both ends. Evidence of calcification occurred inside the implanted ring chambers at 118 and 279 days following implantation in vivo. The calcified matrix produced by the cells had a pattern reminiscent of membranous bone production.


Pharmacology and physiology of stereotyped behavior.


Localization of the noradrenergic nervous system in human brain.


Microbiological studies in submarines. Ecology of Meningococci in symptomless carriers.


Dopamine and the pharmacology of schizophrenia: the state of the evidence.


Multiple ureteral diverticula.

Multiple ureteral diverticula.


Biochemical characterization of the golgi complex of mammalian cells.


Binding properties of the plant photoreceptor phytochrome to membranes.


Human aortic laceration secondary to impact.


Use of sensory recombination and somatosensory deafferentation techniques in the investigation of sensory-motor integration.


Tyrosinase activity and isozymes in B-16 mouse melanomas. B-16 melanomas grown for 13 and 22 days after transplantation in mice were utilized in studies of subcellular distribution of tyrosinase activity and tyrosinase isozyme patterns. The tyrosinase activity utilizing L-tyrosine-14-C was higher in the younger than in the older melanomas. The percent of total activity distributed in the 144,000 g supernatant was 38% for the former and 46% for the latter. Both melanomas had higher percentage of activity confined in the pellet obtained by centrifuging the crude homogenate at 600 g. The digestion of P 600 g pellet by lipase liberated tyrosinase activity which was two fold of the activity originally counted in the pellet. Five isozymes wereobserved in the soluble tyrosinase and two in the solubilized tyrosinase.


A study of the distribution of polychlorinated biphenyls in the aquatic environment.


Analysis of gentamicin in plasma: a comparative study of four methods.


Oral glucose effect on glycogen synthetase and phosphorylase in heart. Muscle and liver.


Photosynthetic nitrogen fixation by blue-green algae.


Clinical picture and management of testicular tumours.


Profile of American health, 1973.

Profile of American health, 1973.


Use of contraceptive services in periods of receipt and nonreceipt of AFDC.


Mutual relations of dorsal and ventral hippocampus with the hypothalamus. I. Hippocampo-hypothalamic projections.


Health and healing practices among five ethnic groups in Miami, Florida.


Home nursing care program on an Indian reservation.


An automated Rose Bengal agglutination test using the ADAM system.


Ocular melanin and the adrenergic innervation to the eye.


Role of lay midwifery in maternity care in a large metropolitan area.


Survival potential and quality of care among free clinics.


The status of prison health care. A review of the literature.


The Public Health Conference on Records and Statistics meeting jointly with The American Association for Vital Records and Public Health Statistics. Highlights of the 15th national meeting.


Outcomes of methadone treatment of 300 innercity addicts.


Phylogeny, hologeny and coenogeny, basic concepts of environmental biology.


Kinetics and other characteristics of diamine oxidase of pea seedlings.


Experimental particle radiation therapy in animal neoplasia. II. Alpha particles versus protons.


Immunoelectrophoretic determination of two IgM paraprotein variants.


Analysis of immunofluorescent preparations based on isolation on DEAE column.


Purification of anti-tetanus human IgG by immunoadsorption.


Isolation of purified IgA and IgM as by-products of ethanol fractionation.


The demonstration of the sensitizing effect of the residual animal serum content of vaccines.


Relation of beta-lactamase activity and cellular location to resistance of Enterobacter to penicillins and cephalosporins. The Enterobacter species E. aerogenes, E. cloacae, and E. hafnia were examined for resistance to penicillin and cephalosporin derivatives. All were resistant to benzyl penicillin, ampicillin, 6 [d(-)alpha-amino-p-hydroxyphenylacetamido] penicillanic acid, cephaloridine, cephalothin, and cephalexin. A significant number were sensitive to carbenicillin and 6 [d(-)alpha-carboxy-3-thienylacetamido] penicillanic acid. No differences among the three species were noted. The beta-lactamase activity was cell-bound, and was not released by osmotic shock, toluene treatment, or diphenylamine treatment. It was rarely released into the growth medium. The beta-lactamase activity was primarily directed against cephalosporin derivatives. Synthesis of beta-lactamase was chromosomally mediated. Resistance to ampicillin seemed to be partly related to entry of the molecule into the bacteria since exposure to ethylenediaminetetraacetate lowered the minimal inhibitory concentration.