The growth of human tumours in immunosuppressed mice and their response to chemotherapy. One hundred and sixteen human tumours were transplanted to thymectomized, irradiated, antilymphocyte serum-treated mice. In 12 cases the recipient mice died rapidly, presumably from infection. With the remaining 104 tumours, three-quarters grew to a varying extent, retaining the characteristic histological features of the primary tumours. Implant nodules varied widely in composition, from solid tumour and stroma to dense fibrous tissue without recognizable tumour cells. There was no relation between degree of malignancy and ability to grow, and also some benign tumours grew.In 44 cases, mice were treated with the drug or drugs most likely to be used in the patients and the effects on the implants were assessed histologically. Two tumours were largely destroyed and one showed marked metaphase arrest. Three other tumours showed lesser changes that were attributable to the drug but were of equivocal significance.There appeared to be differences in drug sensitivity between structurally different clones of the same tumour, and some tumours treated with two alkylating agents were damaged by one and not the other, suggesting that this model may have substantial discriminatory power. Assays such as this should not be used to guide treatment of the patient without prior validation. The practical and ethical difficulties of validation by clinical trial may be insurmountable, and an alternative approach to validation is proposed which does not raise these difficulties.


The hand in mucopolysaccharide disorders.


The high frequency of pharyngeal gonococcal infection in a prenatal clinic population.


The immune response of the mouse to larvae and adults of Nematospiroides dubius.


The immunology of experimental Chagas' disease. I. Preparation of Trypanosoma cruzi antigens and humoral antibody response to there antigens.


The importance of adequate nutrition in closure of small intestinal fistulas.


The influence of experimental mycoplasma infection on the cultivation of measles virus in cell cultures.


The interaction of phalloidin. Some of its derivatives, and of other cyclic peptides with muscle actin as studied by viscosimetry.


The mechanism of the action of anti-D in the prophylaxis of Rhesus sensitization.


The laboratory diagnosis of tropical diseases with special reference to Britain: a review.


The longterm treatment of an asthmatic patient using phentolamine.


The metabolism of a poly(A) minus mRNA fraction in HeLa cells.


The metabolism of methotrexate in Lactobacillus casei and rat liver and the influence of methotrexate on metabolism of folic acid.


The new chronic psychiatric population.

The new chronic psychiatric population.


The nuclear apparatus of ciliophora. Communication 1. Polyploidy of the micronucleus of ciliates as a species characteristic.


The nonspecific large binding of amphiphiles by proteins.


The nutrition problem in India.

The nutrition problem in India.


The occurrence of desmosterol in neuronal and glial fractions from developing rat brain.


The opiate receptor.

The opiate receptor.


The phenogenetics of a super-suppressor in Drosophila melanogaster. IV. Sub-phenotype interactions.


The pathogenic effects on animals fed with mouldy hay or given its etheric fraction.


The posterior maxillary ostectomy: a retrospective study of treatment results.


The presence of the S-100 protein in methylnitrosourea induced tumors of the nervous system in dogs.


The production of antigens by Plasmodium falciparum in vitro.


The production of high potency diphtheria toxin in submerged culture in relatively simple equipment using a semisynthetic medium.


The purification of human factor II (prothrombin) and the preparation of a specific antiserum.


The qualitative dynamics of angina pectoris and the effect of certain drugs as recorded with the high-frequency (acceleration) direct body ballistocardiograph.


The regulation of naphthalene oxygenase in pseudomonads.


The replacement of phosphatidylethanolamine and acidic phospholipids by an ornithine-amide lipid and a minor phosphorus-free lipid in Pseudomonas fluorescens NCMB 129.


The potential of podiatric medicine in comprehensive health care.


The role of embryonic antigens in immunologic sterilization.


The role of prostaglandins in human reproductive function.


The role of surgery and hyperalimentation in therapy of gastrointestinal-cutaneous fistulae. Thirty-eight patients with external gastrointestinal fistulas arising from different levels of the gastrointestinal tract, observed and treated at the Massachusetts General Hospital, from December 1970 to April 1973, are analyzed. Surgical complications were the causes of fistulization in 77% of the cases. The treatment program included parenteral nutrition through a subclavian line in all cases. The 38 patients were fed parenterally for a total of 2311 days. Spontaneous fistula closure occurred in only 11 of the 38 patients. Surgical procedures were necessary in 71.05% of the cases to control fistula complications or persistent fistula drainage. Operative success rate was 70.4%. Parenteral nutrition effects on metabolic parameters, fistula secretion, nutritional status, morbidity and mortality of fistulas are discussed. Parenteral nutrition hazards are also presented. Overall mortality in this series was 21%. Roles of parenteral nutrition and surgery in the total management of external gastrointestinal fistulas are suggested.


The role of zinc in bone metabolism.

The role of zinc in bone metabolism.


The rose bengal plate agglutination test in dairy cattle in Zambia vaccinated over age with strain 19 Brucella abortus.


The specific immunoglobulin response in cattle immunized with isolated Theileria parva antigens.


The specific immunoglobulin response in cattle immunized with Theileria parva (Muguga) stabilate.


The suitability of some media and peptones for sulfonamide testing.


The therapeutic value of oxytetracycline hydrochloride (Terramycin) in cattle infected experimentally with Theileria annulata.


The use of chicken serum for measurement of serum vitamin B12 concentration by radioisotope dilution: discription of method and comparison with microbiological assay results.


The treatment of burns in the recent Middle East conflict.


The use of mercury and alternative compounds as seed dressings. Report of a Joint FAO-WHO Meeting.


The use of Guthrie's test to detect phenylketonuria in a population of mentally retarded individuals.


The IgA system in connection with local and systemic immunity.


The Nation's health and expenditures for health: thoughts on national policy.


The Rh problem through a retrospectroscope. Philip Levine Award presentation.


The Y chromosome and sperm length in D. melanogaster.


The VH3 subgroup of immunoglobulin heavy chains: phylogenetically associated residues in several avian species.


Theileria parva: variation in the infection rate of the vector tick, Rhipicephalus appendiculatus.


The use of Hibitane for hospital disinfection.


Therapeutic efficacy of cromolyn in childhood asthma.


Theileriosis: the exposure of immunized cattle in a Theileria lawrencei enzootic area.


Therapy of seizures in children.

Therapy of seizures in children.


Thermal denaturation of calf thymus DNA: existence of a GC-richer fraction. In 2.5 x 10(-4)M EDTA buffer, the derivative melting curve of calf thymus DNA shows a major band at 47 degrees with a shoulder at about 54 degrees . The fraction of melting area of this shoulder is about 13%. For reconstituted polylysine-calf thymus DNA complexes, in addition to the melting of free DNA regions at about 50 degrees (T(m)) there is another melting at about 106 degrees (T(m)) of polylysine-bound regions. The melting band of the complex at T(m) is not symmetrical. As more polylysine is bound to DNA the melting amplitude is diminished greatly on the major band at 47 degrees but only slightly on the shoulder at 54 degrees . The insensitivity of this shoulder appears to result from the existence of a 13% fraction of calf thymus DNA containing 55% GC. It is not favorably bound by polylysine. It remains in the supernatant after centrifugation and melts at about 54-56 degrees . This conclusion is further supported by two facts: the reconstitution method provides a condition for selective binding of polylysine to AT-rich DNA, and it yields a fully symmetric melting band at T(m) for complexes of polylysine with homogeneous bacterial DNA such as the one from M. luteus.


Thermal elution chromatography and the resolution of nucleic acids on hydroxylapatite.


Three cases of acute ketotic diabetes mellitus with myocarditis: a common viral origin? Focal electrocardiographic abnormalities have been noted in three young adults who developed acute diabetes after an illness bearing the hallmarks of a viral infection. The persistent S-T and T wave changes were inexplicable in terms of acute electrolyte imbalance or ischaemic heart disease and were ascribed to viral myocarditis. The significance of this is discussed.


Tissue ingrowth into mandibular intrabony porous ceramic implants.


Tobramycin: comparative in vitro susceptibility studies.


Toxicity of camptothecin (NSC-100880).

Toxicity of camptothecin (NSC-100880).


Toxicity of neocarzinostatin (NSC-69856): an antitumor antibiotic with radiomimetic and antigenic characteristics.


Toxicology of the prostaglandins.

Toxicology of the prostaglandins. Available published material of adverse reactions to prostaglandins (PGs) at various dosages routes and levels is reviewed.  Animal studies are of 2 kinds: studies of pharmacological effects and studies of toxicological reactions (i.e., acute dose levels).  The pharmacology of PGs show the drugs have 3 areas of action: 1) smooth muscle effects, either contraction or relaxation (cardiovascular effects and reproductive tract; relaxation of vascular smooth muscles by some PGs and contraction by others); 2) nervous system effects; and 3) lipid and carbohydrate metabolism.  In humans, PGE1 was administered intravenously and it was found that adverse effects were related to rate of administration rather than to total dose; side effects included flushing, headache, visual disturbances, and restlessness, factors which might suggest a correlation with central nervous system effects (as found in animal studies).  PGE1 administered at acute doses orally, by inhalation, and intradermally show effects attributable to gastrointestinal disturbances, respiratory problems, and erythematous responses.  In general, studies in humans of other PGs have found similar adverse reactions, all of which are explained by known mechanisms of action of PGs.  Dose levels constituting acutity are dependent on route (i.e., oral doses are much higher than intravenous doses), with rapid intravenous infusion causing the most adverse reactions.


Thymus deprived axenic mice. I. Humoral and cellular immunity after neonatal thymectomy.


Toxicology studies with d-tetrandrine (NSC-77037), a plant alkaloid with vascular and lymphotoxic effects in dogs and monkeys.


Traditional treatment of 194 cases of tetanus.


Transmission of Theileria lawrencei (Serengeti) by the ixodid tick, Rhipicephalus appendiculatus.


Treatment of Paget disease of bone (osteitis deformans). Results of a one-year study with sodium etidronate.


Trifascicular block associated with myocardial infarction.


Tobacco amblyopia.

Tobacco amblyopia.


Turnover of malate-dehydrogenase isozymes in rabbit liver and heart.


Turnover of murein in cellular and filamentous populations of Bacillus megaterium.


Two cases of tuberculous lymphoedema.

Two cases of tuberculous lymphoedema.


Two interconvertible forms of a purified E. coli esterase specific for APNE.


Types of size heterogeneity of IgA molecules isolated from myeloma and normal human serum.


Two new cases of Rh mosaicism. Selective study of red cell populations.


Typhoid hepatitis.

Typhoid hepatitis.


Use of ketamine hydrochloride in the treatment of convulsions.


Tube feeding and lethal aspiration in neurological patients: a review of 720 autopsy cases.


Utilization of gas-liquid chromatography coupled with chemical ionization and electron impact mass spectrometry for the investigation of potentially hazardous environmental agents and their metabolites.


UDP glucuronyltransferase and phenolsulfotransferase in vivo and in vitro. Conjugation of harmol and harmalol.


UDPglucuronosyltransferase of the human placenta.


Variation in morphology of ephemeral fever virus.


Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein.


What can we learn from Sweden?

What can we learn from Sweden?


Vincristine (NSC-67574): a retrospective toxicologic evaluation in monkeys and dogs using weekly intravenous injections for 6 weeks.


What does Chile mean: an analysis of events in the health sector before, during and after Allende's administration.


White enamel patches. A scanning electron microscope study of approximal surfaces following removal of plaque.


X-ray induction of dominant lethals in late spermatids and mature spermatozoa of Drosophila melanogaster: the role of oxygenation.


X-ray-stimulated incorporation of (3H) thymidine triphosphate into DNA of toluenized Bacillus subtilis.


Dark adaptation of separate cone systems studied with psychophysics and electroretinography.


Some aspects of the nonhuman primates of West Malaysia: captivity to the laboratory.


Some basic problems concerning quarantine and safe use of monkeys and apes for biomedical purposes.


Some biological and biochemical properties of toxins (extracellular proteolytic enzymes) of Pseudomonas aeruginosa strains.


Rare femoral erosions and osteoarthrosis of the knee associated with chondrocalcinosis. A histological study of this cortical remodelling.


Tips for travellers.

Tips for travellers.


Size heterogeneity of human prolactin in plasma and pituitary extracts.


Herd incidence of bovine mastitis in four Danish dairy districts. I. The prevalence and mastitogenic effect of micro-organisms in the mammary glands of cows.


Oral leukoplakia associated with tylosis and esophageal carcinoma.


High molecular weight complexes of folic acid in mammalian tissues.


Role of antibody in infections due to Pseudomonas aeruginosa.


Role of dietary restriction in the prevention of infection in leukaemia.


Role of radiotherapy in the treatment of oral cancer.


Note on thresholds in paraplegic man.

Note on thresholds in paraplegic man.


Open subcondylar osteotomy in the treatment of mandibular deformities.


Oral surgical approach to the treatment of Sjögren's syndrome.


Role of calcium in activating soybean lipoxygenase 2.


Long term pulmonary artery pressure monitoring in the management of the critically ill. Detailed experience during prolonged pulmonary artery pressure monitoring (up to 19 days) in 86 seriously ill patients is reviewed. Strict adherence to a protocol developed for insertion and maintenance of Swan-Ganz catheters resulted in successful catheterization of the pulmonary artery in nearly 100% of patients with minimal morbidity. Several technical problems associated with the use of this catheter-monitoring system are described, excessive balloon inflation with resultant misleading, spuriously high pressure measurement being one of the most serious. Most technical problems are avoidable. In the majority of critically ill patients both central venous and pulmonary artery diastolic pressures proved to be in-accurate estimates of pulmonary artery wedge pressure (PAW). PAW was a useful adjunct in the assessment of intravascular volume and hemodynamic alterations in these patients. The Swan-Ganz catheter serves for other functions including collection of mixed venous blood for cardiac output determination and injection of contrast material for small vessel angiography. Measurement of pulmonary artery wedge pressures should be routinely included in the sequential hemodynamic evaluation of most patients sufficiently ill to be hospitalized in an intensive care unit.


Full thickness eye wall resection in various species.


Disk to sphere transformation of erythrocytes, induced by 1-anilino-8-napththalenesulfonate.


Mice tuberculosis quantified by the lung density technique.


Slow virus diseases of the central nervous system.


Cost-benefit in health care: we need to know much more.


Anti-ce (anti-f) in a CDe-cD-mother, as a cause of haemolytic disease of the newborn.


Iron-deficiency anaemia.

Iron-deficiency anaemia.


Dark-field electron microscopy of thin sections of Trichosporon cutaneum. Dark-field electron micrographs of aldehyde-fixed, unstained yeast-phase cells of Trichosporon cutaneum exhibit remarkable contrast and good resolution when the sections studied are less than 25 nm thick and conical illumination is used.


Dose-response relationships of tolbutamide and glibenclamide in diabetes mellitus.


Back-scattering from metals in superficial therapy with high energy electrons.


Mite-sensitive asthma of childhood. Trial of avoidance measures.


Lassa fever.

Lassa fever.


Cell-wall structures of Pseudomonas aeruginosa with immunologic significance: a brief review.


Intracellular site of prolactin synthesis in rat pituitary cells in culture.


Long-term treatment of severe chronic asthma and bronchitis with a long-acting corticosteroid.


Characteristics of Pseudomonas haemolysin.


Characterization of a human saliva antigen precipitated by a lectin from Lotus tetragonolobus.


Characterization of exotoxin of Pseudomonas aeruginosa.


Characterization of temperate bacteriophages of Bacillus subtilis by the restriction endonuclease EcoRI: evidence for three different temperate bacteriophages. Temperate bacteriophages of Bacillus subtilis were characterized according to host range and digestion of the bacteriophage genome by endonuclease EcoRI. The three bacteriophages, phi3T, SPO2, and phi105, were all heteroimmune, and the DNA digests showed dissimilar patterns by agarose-ethidium bromide gel electrophoresis.


Characterization of the phosphorylase b to a converting activity in skeletal muscle extracts of mice with the phosphorylase b kinase deficiency mutation.


Voltage compartments in the lens.

Voltage compartments in the lens.


Passage of protozoa and volatile fatty acids from the rumen of the sheep and from a continuous in vitro fermentation system.


Linkage studies in a large kindred with familial hypercholesterolemia.


Normal anatomy of the larynx and pharynx and the differential diagnosis of foreign bodies.


Cephalothin in the treatment of syphilis.


Anomalous stable aggregates in mixture of TMV and cucumber virus 3 proteins.


Fungal septicemia in surgical patients.

Fungal septicemia in surgical patients. Opportunistic systemic fungal infections are more frequent than generally realized. Increased awareness and a high index of suspicion of fungal super-infection in the presence of sepsis is required to bring about recognition and therapy. The intravenous catheter is an important portal of entry or may act as a foreign body favoring localization of a septic process. In its presence, fungemia must be guarded against. Whenever an intravenous catheter is removed, its tip should be cultured. Removal alone may be a critical item in therapy. In febrile patients, in whom the course of fever is not established, frequent blood cultures with attention directed specifically at fungi should be obtained. Fungi are not easily isolated and identified and only by requesting special attention from the microbiologist can the diagnosis be established in the average institutional laboratory in time to permit appropriate therapy. Since available therapeutic measures are strikingly effective when instituted early, awareness and alertness on the part of the clinician constitute the key to cure.


A  familial occurrence of a mucopolysaccharidosis: Hurler's or Hunter's syndrome?


Histamine receptor-bearing leukocytes (HRL). I. Detection of histamine receptor-bearing cells by rosette formation with histamine-coated erythrocytes.


Intramural oesophageal diverticulosis: a correlation of radiological and pathological findings.


Mechanism of photoaccumulation in Paramecium bursaria.


Mechanism of acquired immunity induced by "Leptomonas pessoai" against Trypanosoma cruzi in mice.


A plant from the family Apocinaceae with antibiotic properties.


Therapy of sickle cell disease: an approach with sodium cyanate.


Therapy in hereditary angioneurotic oedema.


Appearance of Brucella-specific immunoglobulins in synovia of neonatal calves after colostrum feeding.


Preparation of bladder mucosa cells for micro-flow fluorometry.


Comparative analysis of surface charges on luminal epithelial membranes of urinary bladders from toad, frog, turtle, and tortoise.


Comparative effects of oral and parenteral feeding on pancreatic enzymes in the rat.


New apparatus for making standard preparations and pulp exposures for the purpose of pulpal studies.


Comparative morphological and functional aspects of the aorta of the major vertebrate classes.


Comparative specificity of microbial proteinases.


Comparative studies on tomato aspermy and cucumber mosaic viruses. III. Further studies on relationship and construction of a virus from parts of the two viral genomes.


Research on primates in Pakistan.

Research on primates in Pakistan.


Comparison of autoclave and ethylene oxide-sterilized membrane filters used in water quality studies. Autoclave and ethylene oxide-sterilized membrane filters manufactured by Gelman, Millipore, and Sartorius were field tested for their recovery of total coliforms, fecal coliforms, fecal streptococci, and heterotrophs. The data were analyzed by using split-plot analysis of variance and significance tests. Membranes were also tested for pH and toxicity using Escherichia coli. The mean data summaries indicated that Gelman membrane filters generally produced the highest counts during the field studies. Statistical analyses of the March data showed that there were significant differences between membrane filters at 1% level; however, statistical analyses of June data revealed no significant differences except in total coliform recoveries. Toxicity tests at 35 C indicated that Gelman and Millipore autoclaved membrane filters were able to recover 92% of the test organisms. Toxicity tests performed at 44.5 C revealed that no membranes were able to recover more than 40% of the test organisms. Since differences were found in the ability of the three brands of membrane filters to recover bacteria from natural and controlled sources, membrane filters from different manufacturers cannot be readily interchanged. There is a need for a standardized procedure for testing bacterial recovery by membrane filters.


Comparison of constitution of blood of several experimental animals with human blood.


Comparison of electroimmunodiffusion and radial immunodiffusion for measurement of IgG in the laboratory diagnosis of multiple sclerosis.


Comparison of macroscopic, microscopic, and radiometric examinations of clinical blood cultures in hypertonic media. Clinical blood cultures were collected in the Bactec 8A flask (Johnston Laboratories, Cockeysville, Md.) and examined macrosopically, microscopically, and radiometrically in an effort to determine which approach produced the fastest detection time. Of 360 blood cultures found to contain organisms by subculture, 334 were first detected by Bactec, 98 by macroscopic examination, and 68 by microscopic examination. Examination times were at 4, 8, 16, 24, 36, and 48 h after collection of the specimen. Sixteen hours after specimen collection, microscopic examination had detected 31 positive cultures, macroscopic examination had detected two positive cultures, and Bactec had detected 160 positive cultures. By the end of the first 24 h of incubation, Bactec had detected 313 (93%) of those cultures eventually found to be positive. Although Bactec produced the fastest detection time in an overwhelming majority of the cultures, it failed to detect three of three Candida spp. cultures, three of five Bacteroides spp. cultures, and six of 32 Enterococcus spp. cultures during the first 48 h of incubation.


Comparison of the effects of total parenteral nutrition, continuous intragastric feeding, and portacaval shunt on a patient with type I glycogen storage disease.


Primary dysmenorrhea: alleviation by an inhibitor of prostaglandin synthesis and action.


Urinary estrogens as an index for estimating the time of ovulation.


Dietary protein in medical practice.

Dietary protein in medical practice.


Dietary requirements of patients with major burns.


Primary sclerosing cholangitis.

Primary sclerosing cholangitis.


Ultrasonic atlas of normal brain of infant.


Ultrastructural analysis during germination and outgrowth of Bacillus subtilis spores. Electron microscopy of thin sections of dormant and germinating spores of Bacillus subtilis 168 revealed a progressive change in the structure of the cortex, outer spore coat, and inner spore coat. The initial changes were observed in the cortex region, which showed a loose fibrous network within 10 min of germination, and in the outer spore coat, which began to be sloughed off. The permeability of the complex outer spore layers was modified within 10 min, since, at this time, the internal structures of the spore coat were readily stainable. A nicking degradation action of the laminated inner spore coat began at 20 min, and this progressed for the next 20 min leading to the loosening of the inner spore coat. By 30 min, the outer spore coat showed signs of disintegration, and at 40 min, both the outer and inner spore coats were degraded extensively. At 30 to 40 min, a period just preceding net deoxyribonucleic acid synthesis, mesosomes became very prominent in the inner spore core and the cell wall began to thicken around the spore core. At 50 min, an emerging cell was observed, and by 60 min, there was clear evidence for elongation of the emerging cell and the presence of two nuclear bodies. At 90 min, elongation had been followed by the first cell division. There was evidence for spore coat fragments at the opposite poles of the dividing cell.


Ultrastructure of skeletal muscles in protein deficiency.


Ultrastructure of the cell envelope of Pseudomonas aeruginosa: electron microscopic and chemical observations.


Isolation and chemical properties of biologically active fractions of the surface of Listeria monocytogenes.


Isolation and immunological characterization of a unique toxic cytoplasmic polymer of type 1 Neisseria gonorrhoeae.


Inflation and the doctor.

Inflation and the doctor.


Isolation of cell walls from Gram-positive bacteria.


Isolation of human platelets and platelet surface membranes.


Isolation of human reagins differing in their affinity for ragweed immunosorbent.


Oxidation of human serum albumin by polyphenol oxidase.


Isolation of mitochondria from plant material.


Isolation of ureolytic Peptostreptococcus productus from feces using defined medium; failure of common urease tests. Colony counts of fecal samples from three persons, obtained by using a chemically defined anaerobic roll-tube medium (containing glucose, maltose, glycerol, minerals, hemin, B-vitamins, methionine, volatile fatty acids, sulfide, bicarbonate, agar, carbon dioxide (gas phase), and 1 mM NH(4) (+) as main nitrogen source), averaged 60% of the 8.8 x 10(10) bacteria per g obtained when 0.2% Trypticase and 0.05% yeast extract were added to the otherwise identical medium. When 0.2% vitamin-free Casitone replaced Trypticase and yeast extract, counts were 94% those of the more complex medium. When urea-nitrogen was added to the defined medium as the main nitrogen source in place of NH(4) (+), counts of relatively large colonies averaged 1.0 x 10(9) per g of feces from five persons-1.1% of counts on the medium containing Trypticase and yeast extract. All of the organisms from the large colonies in the urea roll tubes were morphologically similar, and all six representative strains isolated were identified as urease-forming Peptostreptococcus productus, a species not previously known to produce urease. Ureolytic strains of Selenomonas ruminantium and P. productus were negative for urease activity in three assay media when inocula were from media containing complex nitrogen sources. The study documents that P. productus is the most numerous ureolytic species so far found in human feces and suggests that NH(4) (+) and more complex organic nitrogen sources strongly repress its production of urease. The study also indicates the efficacy of chemically defined media for direct selective isolation of nutritional groups of bacteria from feces.


Radiation therapy in the treatment of localized carcinoma of the prostate. Preliminary report using 22-MeV photons.


Variations of the first cervical nerve (C1) and the spinal accessory nerve (XI) in the Cercopithecus.


Bureaucracy and medical care.

Bureaucracy and medical care.


Intravenous feeding.

Intravenous feeding.


Geotaxis in protozoa I. A propulsion-gravity model for Tetrahymena (Ciliata).


Ultraviolet sensitivity of Bacillus subtilis spores upon germination and outgrowth. A strain of Bacillus subtilis, UVSSP-42-1, which produces ultraviolet (UV)-sensitive spores and vegetative cells, was found to possess germinated spores 25 times more UV resistant than the resting spores. This relative resistance achieved upon germination was associated with the transition of the heat-resistant refractile spores to the heat-sensitive phase-dark forms. Several generations of outgrowth were required before the cells attained the level of UV sensitivity characteristic of the vegetative cell. The UV sensitivity of germinated spores was compared with other strains with various combinations of mutations affecting deoxyribonucleic acid repair capabilities. The presence of hcr and ssp mutations which are known to abolish the removal of photoproducts from deoxyribonucleic acid did not alter significantly the sensitivity of the germinated forms. However, the addition of the recA mutation and, to some extent, the pol mutation increased the UV sensitivity of the germinated spores. These results indicate that deoxyribonucleic acid repair mechanisms dependent on the recA gene are active in the germinated spores. The chemical nature of the damage repaired by the recA gene product is not known. This study indicates that the life cycle of sporulating bacilli consists of at least three photobiologically distinct forms: spore, germinated spore, and vegetative cell.


Cerebellar stimulation for the control of seizures.


The beta-N-acetylglucosaminidases of Bombyx mori L.


The binding of bilirubin to agar.

The binding of bilirubin to agar.


The binding capacity of albumin and renal disease.


Inhibition of active sodium transport in erythrocytes from burned patients.


Inhibition of prostaglandin synthesis and human epidermal enzymes by aurothiomalate in vitro: possible actions of gold in pemphigus.


Inhibition of transformation of Bacillus subtilis by heavy metals. Mercuric ions, as well as organomercuric ions and cadmium ions, can inhibit deoxyribonucleic acid-mediated transformation in Bacillus subtilis 168 without decreasing the viability of the total population. Differences in the inhibition of transformation by mercuric ions are identifiable on a temporal and concentration dependence basis. Sensitivity to low concentrations (9.2 x 10(-8) M) appears early in the uptake of deoxyribonucleic acid before the transformed markers have become insensitive to deoxyribonuclease. Resistance to "low concentrations" of Hg(2+) is kinetically indistinguishable from the requirement for magnesium in the transformation process. This inactivation is not reversed by the mercury-binding compound glutathione. Sensitivity to mercuric ions at a higher concentration (5.52 x 10(-7) M) occurs after the donor deoxyribonucleic acid has become insensitive to deoxyribonuclease. These complex interactions between mercuric ions and the process of transformation are discussed.


Inhibitory effect of various iron salts on the absorption of tetracycline in man.


Antibody to Vaccinia. I. Detection by immunoelectroendosmophoresis.


Antibody-dependent cell-mediated cytotoxicity. III. Two functionally different effector cells.


Metabolic hydroxylation of a chlorobiphenyl containing only isolated unsubstituted positions--2,2',4,4' ,5,5'-hexachlorobiphenyl.


Metabolic pathways of aprindine.

Metabolic pathways of aprindine.


Metabolism and pathogenicity in Staphylococcus single and mixed cultures and infections.


Handbook on human nutritional requirements.


Cerebroside may be falsely identified as a soluble 'brain specific protein'.


The carbenicillin-gentamicin combination against Pseudomonas aeruginosa. Correlation of effect with gentamicin sensitivity.


Endocarditis caused by Neisseria mucosa in Marfan's syndrome.


The change in DNA ligase activity in B. subtilis cells irradiated by gamma-rays.


Bronchiectasis, eosinophilia, asthma, pneumonitis (BEAP syndrome).


Polychlorinated biphenyl levels in raw and cooked chicken and chicken broth.


A technique for sampling micro-organisms from the pilo-sebaceous ducts.


A sociological viewpoint on laboratory animal science--instinctive and cultural animals.


Toxicity and persistence of PCB homologs and isomers in the avian system.


Toxicity of bacterial sphingomyelinases D.


Toxicity of intravitreal aminoglycosides in primates.


Nosocomial infections due to Pseudomonas.


Nosocomial infections: an overview.

Nosocomial infections: an overview.


A microbiologist looks at aboriginal health. The third A. E. Duxbury memorial lecture, November 27, 1973.


Effect of a synthetic dressing formed on a burn wound in rats: a comparison of allografts, collagen sheets, and polyhydroxyethylmethacrylate in the control of wound infection. Allograft dressings to control Pseudomonas wound infections in rats were studied on surgical wounds and escharectomized burn wounds. The effects of allografts were compared with a collagen sheet (Aviderm) and a synthetic dressing, polyhydroxyethylmethacrylate (Hydron), formed on the wound by mixing the polymer and the solvent. The results indicated that infections in surgical wounds were more easily controlled by dressings than similar contaminations in burn wounds. A procedure was described for the formation of a synthetic dressing directly on the wound from a mixture of polymer and solvent. This type of preparation completely filled the wound area and sealed the edges, preventing further contamination, and gave excellent coverage of the wound. With 24 h of coverage of escharectomized burn wounds, allografts provided the best dressing for reduction of wound organisms. At 96 h of coverage, Hydron and Aviderm produce significant reductions in the Pseudomonas resident in the burn wound. The results support the thesis that suitable dressings promote local host defense processes which kill the contaminating bacteria.


Effect of butterfat on inhibition of Staphylococcus aureus by nisin.


Effect of ehxachlorophene on hepatic drug-metabolizing enzymes in the rat.


Effect of prostaglandins E1 and F2alpha on milk yield in lactating rats.


Effect of specific antibodies on biological functions of the envelope components of Newcastle disease virus.


Effect of starvation on the response to erythropoietin in the rat.


Effect of sublethal doses of urethan in adult cattle.


Effect of thyrotropin-releasing (TRH) upon the menstrual cycle in women.


Effect of Listeria-factor Ei on spleen cells migration in rabbits hypersensitive to Listeria monocytogenes.


Effect of Neisseria gonorrhoeae on human and rabbit oviducts.


Effect of experimental removal of molars on gastric and submaxillary salivary secretion in the rat.


Detection of dynamite residues on the hands of bombing suspects.


Induction deficiency of the microsomal UDPglucuronosyltransferase by 3-methylcholanthrene in Gunn rats.


Induction of granulomatous hepatitis in mice infected with group A streptococci and treated with penicillin.


Induction of protein synthesis in mitochondria by exogenous RNA. Synthesis of rabbit globin by isolated mitochondria of Tetrahymena pyriformis.


Induction of sporulation during synchronized chromosome replication in Bacillus subtilis. Synchronous chromosome replication was obtained in a culture of Bacillus subtilis temperature-sensitive mutants growing in a rich medium. At intervals during this replication, samples of cells were transferred to a poor medium to induce sporulation. The results show that the capacity of B. subtilis for induced sporulation reaches a peak about 15 min after chromosome replication has begun. This capacity then declines rapidly, but can be restored by initiating a new round of deoxyribonucleic acid replication. The possibility is discussed that sporulation can be induced only when the chromosome replication fork is passing through a stage 0 operon and that this may be located in the cysA-sul(R) region of the chromosome.


Olfactory communication in South American primates.


Effects of different temperature doses and their fractionation on crossing over in females of Drosophila melanogaster.


Effects of ethyleneglycol dinitrate and related compounds on ethanol preference and ethanol metabolism.


Effects of protease activity in crude mutanase on caries and plaque in rats.


Effects of nitrogen dioxide and ozone on monkey lung ultrastructure.


Effects of wall inhibitors on thymineless Streptococcus faecalis.


Effects of EDTA on stability of drug metabolizing enzymes in liver microsomes of rats.


Structural heterogeneity of the protease isolated from several strains of Staphylococcus aureus.


Structural proteins of adenoviruses. XI. Purification of three low molecular weight virion proteins of adenovirus type 2 and their synthesis during productive infection.


Doxycycline HC1 (Vibramycin) syrup as a single-dose oral treatment for uncomplicated urethritis in men.


Lipid composition as a guide to the classification of bacteria.


Blood group isoantigens in angioblastic meningiomas and hemangioblastomas of the central nervous system.


Rapid isolation techniques for chloroplasts.


Blood protozoa of wild turkeys in Florida.


The defect in hemophilic and von Willebrand's disease plasmas studied by a recombination technique. Factor VIII in preparations from normal plasma is a large glycoprotein of greater than 2 million molecular weight which elutes in the exclusion volume of 4% agarose gels at an ionic strength of 0.15. Recent studies have demonstrated that the factor VIII in canine and bovine plasma is a macromolecular complex composed of a large inert carrier protein and a noncovalently bound small fragment which contains the procoagulant active site. This complex is dissociable in 0.25 M CaCl(2), and conditions for its recombination have been reported. The present study reports the dissociation characteristics of normal human factor VIII preparations in 0.25 M CaCl(2) and the ability to achieve quantitative recombination of the dissociated fragments of normal human and bovine factor VIII after the removal of Ca(2+). The recombination technique was used to characterize further the defect in hemophilia and von Willebrand's disease. Void volume preparations from human hemophilia A(-), canine hemophilia A, and human von Willebrand's plasma, with no factor VIII procoagulant activity, were mixed with the small active fragment prepared from the normal plasma of their respective species. Chromatography of the three mixtures in agarose gel showed that the fractions from the human hemophilic plasmas contained a molecule that bound the small active normal fragment, but neither the fractions from canine hemophilia A plasmas nor the fractions from the human von Willebrand's plasmas demonstrated evidence of such material. These data suggest that there is present in human hemophilia A plasma a normal functional carrier molecule which is absent or nonfunctional in the plasma of hemophilic dogs and humans with von Willebrand's disease.


Deiodination of l-thyroxine in vitro by peripheral leukocytes from rhesus monkeys with bacterial sepsis.


Breeding of the Japanese monkey on an island as a laboratory animal.


Pseudomonas aeruginosa and the general hospital: a six-year survey. The incidence of infections caused by Pseudomonas aeruginosa did not increase significantly among general surgical and medical patients between 1967 and 1972, and the majority of such infections were trivial. Serious infections were virtually confined to the intensive care unit and the renal transplant unit, and were usually associated with major trauma, surgical mishap or immunosuppression. The majority of these patients had received prior antibiotic therapy. Persistent isolation of Ps. aeruginosa from surgical wounds was often associated with severe intra-abdominal sepsis, and antibacterial therapy was commonly ineffective in these cases. Apparently susceptible patients did not necessarily acquire infection, though the organism was present in their environment. It is suggested that this may reflect a variation of virulence among environmental strains of Ps. aeruginosa, and that further study of this aspect may contribute to improved control of infection.


Pseudomonas aeruginosa infection and humoral antibody response of patients with cystic fibrosis.


Pseudomonas endocarditis: hemagglutinating antibodies to Fisher-Devlin-Gnabasik immunotypes in sera.


Rhabdomyomatous dysplasia of the lung.

Rhabdomyomatous dysplasia of the lung.


Pyridoxal and folate deficiency in alcoholics.


Pyridoxal, vitamin B12 and folate metabolism in women taking oral contraceptive agents.


Spondyloepiphyseal dysplasia.

Spondyloepiphyseal dysplasia.


Acute adrenal insufficiency.

Acute adrenal insufficiency.


Café au lait spots without giant pigment granules. Occurrence in suspected neurofibromatosis.


Spore dimorphism in a microsporidan isolate.


Residues of polychlorinated biphenyl in products from poultry fed Aroclor 1254.


Spoke heads in sperm tail of Drosophila melanogaster.


Ozone and glycol vapor decontamination of air in a closed room.


Do we need a computer? A review of data processing applications in nuclear medicine and radiotherapy.


State of nutrition in preschool children in Tehran. I. Calorie and protein intake.


Value of the concomitant use of complement fixation and immunodiffusion tests in the diagnosis of coccidioidomycosis. Complement fixation titers of 1:2 and 1:4 with coccidioidin are not always of diagnostic significance. The concurrent use of the complement fixation and immunodiffusion tests is an effective means for specific serologic diagnosis of coccidioidomycosis in patients with low levels of complement-fixing antibodies. In routine testing, it is recommended that only sera that are negative for complement-fixing antibodies at 1:8 but positive in the immunodiffusion test with coccidioidin be selected for titration at the 1:2 and 1:4 levels.


Value of HCG and HCS measurement in clinical practice.


Phage typing of Pseudomonas aeruginosa: clinical and epidemiologic considerations.


Three sisters with the Smith-Lemli-Opitz syndrome.


Permeability modulating membrane coats. I. Fine structure of fluid segregation organelles of peritrich contractile vacuoles.


Permeability of lipopolysaccharide-deficient (rough) mutants of Salmonella typhimurium to antibiotics, lysozyme, and other agents.


Increase in the mass of RNA-containing bodies in the nuclei of slaivary gland cells of lethal larvae of Drosophila melanogaster line ltl (lethal tumorous larvae).


Close-up. Standard breast examination.

Close-up. Standard breast examination.


Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation.


Projection of the vestibular nerve to the area 3a arm field in the squirrel monkey (saimiri sciureus).


Closed condylotomy in the treatment of idiopathic and traumatic pain-dysfunction syndrome of the temporomandibular joint.


Proceedings: Apiosoma pisicola Blanchard, 1885, and Epistylis lwoffi Fauré-Fremiet, 1943 (Protozoa: Peritrichida) on three-spined stickleback, Gasterosteus aculeatus L., in Wales.


Proceedings: Concanavalin A (con A) induced redistribution of surface receptors on Land-Schutz ascites tumour (LAT) cells and its inhibition by glutaraldehyde prefixation and low temperature.


Proceedings: Some effects of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on calcium metabolism in man.


Proceedings: Prediction of response to antihormone treatment using an in vitro test for dependence of hormones.


The effect of antibodies to two human seminal plasma-specific antigens on human sperm.


The effect of copper intrauterine devices on endocervical gonococcal cultures.


The effect of complement and other cell wall reagents on tetracycline and streptomycin resistance in Pseudomonas aeruginosa.


The effect of leukocyte hydrolases on bacteria. II. The synergistic action of lysozyme and extracts of PMN, macrophages, lymphocytes, and platelets in bacteriolysis.


The effect of radiation on microbiologic characteristics of M tuberculosis.


The effects of bacterial pyrogens and leucocytic pyrogen upon gastric motility and heart rate frequency in conscious goats.


The effects of calcium and calcium-chelating agents on the aspartate-isolated frog PIII response.


The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.


The effects of force-feeding on enzymes of the liver, kidney, pancreas and digestive tract of chicks.


Protein deprivation in primates. II. Effects of fondling on feeding behavior of discomforted infant rhesus monkeys.


Protein binding by specific receptors on human placenta, murine placenta, and suckling murine intestine in relation to protein transport across these tissues. Human, rat, and mouse placentas and rat and mouse intestines were homogenized in buffered saline, and fraction consisting primarily of cell membranes was separated from each of the homogenates by differential centrifugation. Human, bovine, and guinea pig IgG, and human IgE, Bence-Jones protein, serum albumin, insulin, and growth hormone were labeled with (131)I or (125)I, and the binding of these proteins by the cell membrane fractions was investigated. Rat and mouse sucklings were given labeled proteins intragastrically, and the amount of each protein absorbed after a given interval of time was determined. It was found that the degree and specificity of protein binding by the cell membrane fractions from human and murine placentas strikingly paralleled the relative rate and specificity of protein transport from mother to fetus in the respective species at or near term. Similarly, the degree and specificity of protein binding by the cell membrane fractions from suckling rat and mouse intestines tended to parallel the rate and specificity of protein absorption from the gastrointestinal tract in these animals. However, some discordance between protein binding and protein transport was also observed. The data suggest that: (a) the binding of a protein by specific receptors on cell membranes may be a necessary first step in the transcellular transport of the protein; (b) specific protein binding by cell receptors does not ensure the transport of that protein across the tissue barrier; and (c) specific transport mechanisms other than or in addition to specific cell membrane receptors are involved in the active transport of proteins across the human or murine placenta or the suckling murine intestine.


Protein status of general surgical patients.


Proteins in fluid from non-keratinizing jaw cysts. 4. Concentrations of immunoglobulins (IgG, IgA and IgM) and some non-immunoglobulin proteins: relevance to concepts of cyst wall permeability and clearance of cystic proteins.


Proteins in world nutrition.

Proteins in world nutrition.


Platelet macroglycopeptide.

Platelet macroglycopeptide.


Correlation and clusteranalytic studies about histological characteristics of the colon-rectum-carcinoma.


A preliminary report on pigskin grafts in oral surgery.


Evidence for a cytochrome b in green bacteria.


Epidemiology of infectious hepatitis.

Epidemiology of infectious hepatitis.


Evidence for a diurnal rhythm in ovarian steroid secretion in the rhesus monkey.


Evidence of carbonic anhydrase activity in skeletal muscle: a role for facilitative carbon dioxide transport.


Screening for cystic fibrosis by examination of meconium.


Congenital dyserythropoietic anemia with ultrastructure findings compatible with both types I and II.


Patient presentations.

Patient presentations.


Current treatment of status asthmaticus.


Segmental disorganizing glomerulonephritis in a Wegener's granulomatosis.


Sequential scintigraphy of the salivary glands with special reference to the oral activity.


Precentral motor cortex and mastication.


Prevention of lymphoma in cotton-top marmosets by Herpesvirus saimiri antiserum.


Stereopsis and fusion.

Stereopsis and fusion.


Isopeptide crosslinks--their occurrence and importance in protein structure.


Letter: A new antithrombin III assay.

Letter: A new antithrombin III assay.


Cancer of the nasopharynx. Incidence, clinical course and results of therapy: a report from Greece.


Letter: Alpha-fetoprotein and Rh alloimmunization.


Letter: An unconventional legume--Prosopis cineraria.


Letter: Antigenic relationship of salmonellae and schistosomes.


Letter: Bladder diverticula.

Letter: Bladder diverticula.


Letter: Danger of inadequate administration of potassium.


Letter: Correlation of the efficiencies of some radiation sensitizers and their redox potentials.


Letter: Method for removing a knotted nasogastric feeding tube in an infant.


Letter: Nutritional recovery syndrome.

Letter: Nutritional recovery syndrome.


Letter: Pentazocine and neonatal withdrawal symptoms.


Letter: Psychosis associated with sympathomimetic and cromoglycate therapy.


Letter: Scrapie.

Letter: Scrapie.


Letter: Screening for phenylketonuria in mental retardates in Hyderabad using Guthrie's test.


Letter: Silicone membrane oxygenator.

Letter: Silicone membrane oxygenator.


Letter: The dangers of hypoglycaemia on oral hypoglycaemia agents.


Letter: TSH level and thyroid function.

Letter: TSH level and thyroid function.


Letter: Venospasm during cardiac catheterization.


Letter: Why under-five's clinics?

Letter: Why under-five's clinics?


Cooperation and cell-mediated cytotoxicity as functions of two subsets of T cells.


Temperature-sensitive mutants of Bacillus subtilis defective in spore outgrowth.


Temperature-induced changes in the sporicidal activity and chemical properties of glutaraldehyde. Freshly prepared 2% acid and alkaline glutaraldehyde solutions were stored at 4, 20, and 37 C. At intervals, samples were removed and changes in pH, ultraviolet spectrum, and sporicidal activity (against Bacillus pumilus spores) were recorded. Alkaline solutions stored at 4 C showed little changes in these properties, whereas such solutions stored at 37 C became turbid and showed a decrease in pH, marked changes in ultraviolet spectrum, and an almost complete loss of sporicidal activity. Intermediate results were obtained with alkaline solutions stored at 20 C. In contrast, acid 2% glutaraldehyde solutions (initial pH 3.5) showed comparatively few changes in their properties. Treatment of spores with freshly prepared glutaraldehyde solutions (0.5%) at temperature above 40 C reduced the effect of pH on sporicidal activity.


Bacteremia due to Pseudomonas aeruginosa complicating neoplastic disease: a progress report.


Differences in the intensity of 59Fe incorporation into various regions of bone marrow of C57BL-10 mice after acute radiation exposure.


Differentiation of fibrinogen degradation products (FDP) in plasma by precipitation with polyethylene glycol.


Posterior malleolar fractures.

Posterior malleolar fractures.


Properties and regional distribution of cerebral CMP-N-acetylneuraminic acid: glycoprotein sialyltransferase.


Properties of the competence-inducing factor of Bacillus subtilis 168I-.


Conservative and surgical treatment of condylar fractures of the temporomandibular joint.


Conservative treatment and long-term follow-up of retinal tumours.


Diabetes in American Indians and other native populations of the New World.


Secretion of serum albumin by enzymatically isolated rat liver cells.


Letters: Reply to 'comparative anatomy of the talus in relation to idiopathic club foot'.


The experimental effect of direct electrical current on intracranial arteries and the blood-brain barrier.


The experimental production of vitamin B12 deficiency in the baboon (Papio cynocephalus). A 2-year study.


The experimental induction of localised skeletal tuberculous lesions and their accessibility to streptomycin.


Cat-eye syndrome: evaluation of the extra chromosome with banding techniques. Case report.


The familial association of neurofibromatosis, peroneal muscular atrophy, congenital deafness, partial albinism, and Axenfeld's defect.


Non-fatal ketoacidosis in a 94-year-old diabetic patient.


Purification of tetanus toxin and toxoid by ion exchange chromatography.


Purification and serology of viruslike particles from Fiji disease virus-infected sugar cane.


Sidney Farber (1903-1973).

Sidney Farber (1903-1973).


The fine structure of Lankesterella sp. sporozoites parasitic in the frog Rana pipiens.


The flexibility of bacterial cell walls.


SF6 for retinal detachment surgery. A preliminary report.


Antigen of mouse bile capillaries and cuticle of intestinal mucosa.


The genetic control of antibody binding constants and specificities in inbred rats.


Changes in the fine structure of the dental pulp in human caries pulpitis. 1. Nerves and blood vessels.


The genetic structure of natural populations of Drosophila melanogaster. XII. Linkage disequilibrium in a large local population. Seven hundred and three second chromosomes were extracted from a Raleigh, North Carolina population of Drosophila melanogaster in 1970. Additionally, four hundred and eighty-nine third chromosomes were extracted from a large cage population founded from the flies in the 1970 Raleigh collection. The alpha glycerol-3-phosphate dehydrogenase-1, malate dehydrogenase-1, alcohol dehydrogenase, and alpha amylase loci were studied from the second chromosomes, and the esterase-6, esterase-C, and octanol dehydrogenase loci were analyzed from the third chromosomes. Inversions, relative viability and fecundity were studied for both classes of chromosomes. The following significant findings were obtained: (1) All loci examined were polymorphic or had at least two alleles at appreciable frequencies. Analysis of the combined data from this experiment with that of Mukai, Mettler and Chigusa (1971) revealed that the frequencies of the genes in the second chromosomes collected in early August were approximately the same over three years. (2) Linkage disequilibria between and among isozyme genes inter se were not detected except in a few cases which can be considered due to non-random sampling. (3) Linkage disequilibria between isozyme genes and polymorphic inversions were detected when the recombination values between the breakage points of the inversions and the genes in question were small. In only a few cases, were second and third order linkage disequilibria including polymorphic inversions detected. (4) Evidence for either variation among genotypes within loci or cumulative effects of heterozygosity was found for viability and fecundity. As a result of these findings, it was tentatively concluded that although selection might be perceptibly operating on some polymorphic isozyme loci, most of the polymorphic isozyme genes are selectively neutral or near-neutral in the populations studied.


Changes in the fine structure of the dental pulp in human caries pulpitis. 2. Inflammatory infiltration.


Hemagglutinating properties of viruses of the phlebotomus fever group.


Hexagonal arrangement of intragranular particles in human basophilic leucocytes.


Esophageal intramural pseudodiverticulosis.


Esophageal intramural pseudodiverticulosis: a disease of adnexal glands.


The hatching process in fish embryos. IV. The enzymological properties of a highly purified enzyme (chorionase) from the hatching fluid of the rainbow trout, Salmo gairdneri Rich.


On the role of mononuclear phagocytes in immunity against viruses.


Further isolations of non-flagellate Pseudomonas aeruginosa. Three strains of non-flagellate Ps. aeruginosa isolated from pathological specimens have already been described. The purpose of this paper is to report further isolates. All strains have been shown to be different types isolated from a variety of infections.


Biochemical and genetic characterics of deletion and other mutant strains of Salmonella typhimurium LT2 lacking alpha-keto acid dehydrogenase complex activities,.


Further studies on leptospiral genus-specific antigen: its ultrastructure and immunochemistry.


Synthesis of a 5-nitrofuran derivative of expected antimicrobial action.


The histidine-binding protein J, a histidine transport component, has two different functional sites.


Weight changes in patients with intermaxillary immobilization after jaw fractures.


Morphometric studies of mitochondria in Tetrahymena pyriformis exposed to chloramphenicol or ethidium bromide.


Prophylactic neck dissection in oral carcinomas.


Staphylococcal enterotoxin B and nuclease production under controlled dissolved oxygen conditions. Enterotoxin B, nuclease, and total exoprotein production by Staphylococcus aureus strain S-6 was studied in a 0.5-liter fermentor system. While these extracellular products were elaborated over a wide range of aeration rates, maximal production occurred within the very narrow range of 125 to 150 cm(3) of air per min. The levels attained at the optimal aeration rate were not increased by maintaining a constant pH, although yield of enterotoxin:cell mass was highest at a constant pH of 7.0. During the growth cycle of the cultures, when aeration rate alone or aeration rate and pH were held constant, the dissolved oxygen (DO) levels, initially set at 100% of saturation, decreased to 5 to 10% 4 to 5 h after inoculation. The oxygen demand of the culture then maintained this level for an additional 4 to 6 h. This interval of low DO was characterized by maximal growth and exoprotein production. When the DO was controlled at a constant value throughout growth (by increasing or decreasing the airflow rate as appropriate), the culture demonstrated different optima for maximal growth and exoprotein production. A constant DO of 100% stimulated growth to extremely high densities, but the accumulation of toxin and nuclease was not observed. On the other hand, maintaining constant DO levels at 50 or 10% raised exoprotein levels higher than those achieved in a culture grown at the optimal aeration rate. Compared to the optimal aeration rate culture, the 10% DO culture yielded 20% more nuclease, 25% more toxin, and 40 to 50% more total exoprotein. These results indicate that it is the DO and not the aeration rate, per se, that is influential in controlling growth, toxin, nuclease, and total exoprotein production.


Cardiac tamponade and death in a patient receiving total parenteral nutrition.


Partial nucleotide sequence of a prokaryote initiator tRNA that functions in its non-formylated form.


Partial purification of aflatoxins by simple chemical fractionation.


Gentian violet as a possible fungal inhibitor in poultry feed: plate assays on its antifungal activity.


Mandibular ostectomy in acromegalic.

Mandibular ostectomy in acromegalic.


Acidic proteins in cerebral and hepatic microsomes: isolation of a protein (AGL-40) compounds primarily of glutamyl, aspartyl and lysyl residues with hematin-binding properties.


Clinical and epidemiological correlates of Pseudomonas typing.


Surgical and esthetic aspects of the facial profile.


Physical and functional homology between ribosomal protein S1 and interference factor i.


Physical evidence for the oxidative demethylation in vitro of 1-naphthyl N-methylcarbamate by the Udenfriend chemical hydroxylation system.


Clinical examinations on the Japanese monkey (Macaca fuscata).


Clinical experience with space diet in pediatric surgery.


Surgical orthodontic treatment of facial asymmetry using direct bonding plastic brackets.


Application of enamel adhesives in oral surgery.


Replication of measles virus: continued synthesis of nucleocapsid RNA and increased synthesis of mRNA in the presence of cycloheximide. The effect of cycloheximide on virus specific RNA synthesis in Vero cells infected with either wild-strain (Edmonston) or subacute sclerosing panencephalitis strain measles virus was investigated. At 3 days postinfection, cells treated with cycloheximide (2.6 x 10(-4) M) and then exposed to [(3)H]uridine showed a marked increase in labeled virus-specific RNA. A major portion of this incremental labeled RNA was putative viral mRNA which sedimented at 16, 22, and 30S. Five distinct classes of polyribosomes, which were not evident in untreated cells, were found in cycloheximide-treated cells and each contained similar species of virus-specific RNA. Viral nucleocapsid RNA, 50 and 18S, was synthesized and encapsidated in the presence of cycloheximide. The latter observation is in apparent contrast to reports that cycloheximide inhibits replication of RNA of classical paramyxoviruses, and may indicate that mechanisms for replicating RNA of measles virus are different from those for replicating RNA of paramyxoviruses.


Sporicidal activity of hospital disinfectants. The sporicidal activity of hospital disinfectants was tested using two methods of test and two species of spores. Alcoholic hypochlorite and glutaraldehyde (Cidex) showed some sporicidal activity; the first was the more effective. Iodophors, formalin, and phenolics were less effective, in descending order. Chlorhexidine showed no activity.A freshly prepared solution containing 50% methanol and sufficient sodium hypochlorite to provide 2000 parts per million available chlorine in distilled water, with a contact time of 15 minutes, is suggested for the decontamination of clean, heat-sensitive instruments except those of plated metal. It must be understood that no such method can be depended upon to sterilize.The instruments should be rinsed in sterile water before use after decontamination.


Difficulties in and indications for the treatment of facial asymmetry.


Candida osteomyelitis associated with intravenous alimentation.


Studies of the spontaneous rosette-forming cells in the bursa of Fabricius of the chicken.


Studies on a soluble dipeptidase from pig intestinal mucosa. Enzymatic properties.


Studies on in vivo degradation of rat hepatic catalase with or without modification by 3-amino-1,2,4-triazole.


Studies on the bacteriophage 2 receptors of Pseudomonas aeruginosa. The lysogenization of Pseudomonas aeruginosa strain BI with phage 2 resulted in the loss of the capacity to adsorb the same phage. The absence of phage 2 receptors on the surface of the lysogenized strain BI(2)(8) was confirmed by the failure of purified slime polysaccharide (SPB) or lipopolysaccharide (LPS) to inactivate phage 2. SPB and LPS from a phage 2-resistant strain also failed to inactivate phage 2 in contrast to the phage inactivation exhibited by the SPB and LPS obtained from the wild-type strain BI. Chemically, quantitative differences were apparent when the SPB and LPS of strains BI(2)(8) and BI/2S(2) were compared with those of the wild-type strain BI. The most striking difference noted was the absence of amino sugars in the SPB of strain BI/2S(2). The SPB of strain BI(2)(8) also contained a lower percentage of amino sugars compared with the SPB of the wild-type strain BI.


Studies on the gestational changes in the buffalo uterus. II. The histochemical characteristics.


Studies on the passage of alpha-chymotrypsin across the intestine. II. Enzymic activity and radioactive macromolecule recovered in the mesenteric perfusate.


Studies on the pathogenesis of ischemic cell injury. I. Relations between ion and water shifts and cell ultrastructure in rat kidney slices during swelling at 0-4 degrees C.


Studies on the substrate specificity of the phospholipase A1 of the plasma membrane of rat liver.


Significance of immunofluorescent staining of lymphocytes with antisera to IgM immunoglobulins.


Specific IgG and IgM antibody responses in herpes-simplex-virus infections.


Significance of neuronal alterations in developing cortical infarction.


Specificity of the local secretory antibody to influenza A virus infection.


Significance of Pseudomonas aeruginosa in the patient with leukemia or lymphoma.


Specificity of the protective response induced by the slime layer of Pseudomonas aeruginosa. Active protection against Pseudomonas aeruginosa could be induced in mice by immunization with either the phenol killed cells or the alcohol precipitated fraction of the slime layer, or the ribosomal vaccine preparation. Passive protection could also be induced by injecting into mice antisera prepared in rabbits against these bacteria. This protection was due to the production of antibodies in reaction to the slime layer; the absorption of these antibodies by the slime caused the loss of protection. The fact that mice were also protected by vaccination with strains other than those used for challenging was attributed to the presence of an antigenically similar slime. Passive protection towards a heterologous strain, even one with an antigenically similar slime layer, was dependent on the dose of the challenging injection.


A weight chart and weighing scale for nutrition surveys and grading of malnutrition in clinics.


Stability of minute virus of mice to chemical and physical agents. Minute virus of mice (MVM), a single-stranded deoxyribonucleic acid Parvovirus, was subjected to various inactivation procedures, including chemical disinfectants, heat, and ultraviolet radiation. MVM was found to be less stable than has been reported for other Parvoviruses. This virus was readily inactivated by a variety of chemical disinfectants, including alcohols, formaldehyde, glutaraldehyde, and chloroform. MVM was more sensitive to ultraviolet radiation than was Kilham's rat virus. MVM was more sensitive to heating at temperatures of 35 to 100 C than has been reported for other Parvoviruses. More than 95% of MVM infectivity was inactivated by heating (45, 60, or 100 C) for 60 min, acid (pH 2.0) treatment, or ultraviolet radiation treatment, although a small percentage (less than 2%) of the virus preparation was found to be resistant to these treatments. In addition, more than 99% of the infectivity of MVM was lost after storage at 4C for 10 weeks, although the virus was stable on storage in liquid nitrogen.


Specimen holder to critical-point dry microorganisms for scanning electron microscopy. Critical-point drying of microorganisms for scanning electron microscopy can be rapidly and effectively accomplished by use of a newly described specimen holder. Up to eight different samples of spores or vegetative cells are placed between polycarbonate membrane filters in the holder and processed through solvent dehydration and critical-point drying using carbon dioxide without loss or cross contamination of microorganisms. Yeasts, molds, bacteria, and actinomycetes have been successfully processed.


Preliminary investigations of Pseudomonas aeruginosa vaccine in patients with leukemia and cystic fibrosis.


Non-immunological precipitation of serum by sodium dodecyl sulfate in agar diffusion. Marmoset serum or serum of other species of animal may react with sodium dodecyl sulfate and forms nonspecific precipitin lines in agar diffusion. The protein detergent complexes are not readily dialyzable. Therefore precipitin lines derived from studies that use sodium dodecyl sulfate-treated antigens in agar diffusion must be interpreted with caution.


Preliminary studies on an atypical strain of bovine Theileria isolated in Kenya.


The immunological response of the rat to infection with Taenia taeniaeformis. I. Immunoglobulin classes involved in passive transfer of resistance.


The importance of memory traces of motor efferent discharges for learning skilled movements.


The immunological response of the rat to infection with Taenia taeniaeformis. II. Characterization of reaginic antibody and an allergen associated with the larval stage.


Origin and structure of the group-specific, complement-fixing antigen of Rickettsia rickettsii. Rickettsia rickettsii was treated with ether and examined by negative-contrast electron microscopy. Group-specific complement-fixing antigen was seen to be originating from the cell wall. The antigen was composed predominately of round particles 10 to 60 nm in diameter. Intact R. rickettsii and antigen from ether-treated organisms were purified by density gradient centrifugation and analyzed by polyacrylamide gel electrophoresis. The whole rickettsial cell was composed of a minimum of 30 proteins which ranged in molecular weight from about 23,000 to 155,000. The "soluble" antigen contained nine proteins ranging in molecular weight from about 28,000 to 150,000.


Pyocin typing of Pseudomonas aeruginosa.


Junín virus.

Junín virus.


A thin-layer chromatographic technique for rapid estimation of bacterial lipases.


Termination of retinofugal fibers in squirrel monkey: a re-investigation using autoradiographic methods.


The incidence of enterotoxin production in strains of Staphylococcus aureus isolated from foods.


The incidence of Brucella infections in producer-retailer herds in North Lancashire from 1965 to 1972. The results are presented of testing untreated producer-retailer herd milk samples for the presence of Brucella abortus during the period 1965-1972 in the North Lancashire region.There was a steady decline in the incidence of infected herds from 22% in 1965 to 12% in 1971. A sharp fall to 5% in 1972 suggests that the introduction of the Brucellosis Incentives Scheme and the eradication programme has helped to reduce the practice of selling brucella-infected cattle in the open market which was prevalent in the period 1965 to 1970.This practice of selling brucella-infected cattle may also be a prime factor in the changing pattern of distribution of the biotypes of B. abortus which was observed during the period 1965 to 1970.A comparison of the two areas in the region show that the incidence of herd infection was always greater in the area containing flying herds than in the area in which self-contained herds predominated.


ATP-independent, DNA synthesis by DNA polymerase II in toluenized Bacillus subtilis.


Combined hyperthermia and radiation suggest and alternative to heavy particle therapy for reduced oxygen enhancement ratios.


The influence of age on salivary content and rate of flow.


The influence of dietary PCB on the PCB content of carcass lipid in broiler chickens.


The influence of serotonin on crypt cell proliferation in the jejunum of rat.


The influence of tongue asymmetries on the development of jaws and the position of teeth.


Binding assays for amino acids. The utilization of a cystine binding protein from Escherichia coli for the determination of acid-soluble cystine in small physiological samples.


Binding of 1,N6-ethanoadenosine triphosphate to actin.


Binding of (14C)penicillin G to the membrane-bound and the purified D-alanine carboxypeptidases from Bacillus stearothermophilus and Bacillus subtilis and its release.


Tracing the bulk outflow route of cerebrospinal fluid by transmission and scanning electron microscopy.


Mapping the delta-aminolaevulinic acid dehydrase and porphobilinogen deaminase loci in Bacillus subtilis.


The inhibition of lipid autoxidation by human serum and its relation to serum proteins and alpha-tocopherol.


The intravitreal use of carbenicillin (Geopen) for treatment od pseudomonas endophthalmitis.


Estriol conjugates in amniotic fluid of normal and Rh-isoimmunized patients.


Section meeting on immunology and immunotherapy.


Is lipid lost during preparation of erythrocyte membranes?


Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines.


Multiple molecular forms of serum alpha1-antitrypsin.


Multiple recurrent fibro-osseous epulides.


Protirelin (TRH) in depression.

Protirelin (TRH) in depression.


The isolation of gas vesicles from blue-green algae.


Sensitivity of different Pseudomonas species and Aeromonas hydrophila to trimethoprim and sulfamethoxazole separately and in combination.


Precitpitating antibodies to canine lymphosarcoma-associated antigens.


Density of parasites in various organs and the relation to numbers of trypomastigotes in the blood during acute infections of Trypanosoma cruzi in mice.


Lithium and the pituitary-thyroid axis in normal subjects.


Cultivation of Besnoitia besnoiti Marotel, 1912, in cell culture.


In vivo studies on reversion to sensitivity of INH-resistant tubercle bacilli under the influence of dimethylsulfoxide (DMSO).


Passive ion fluxes across toad bladder.

Passive ion fluxes across toad bladder.


Persistence in soil and losses in runoff of soil-incorporated carbaryl in a small watershed.


Hodgkin's disease.

Hodgkin's disease.


Focal adrenalitis. Its frequency and correlation with similar lesions in the thyroid and kidney.


Local antibody formation in the brain of chickens.


Small bowel in immunoglobulin deficiency syndromes.


Osmolality of hyperalimentation solution infused into the superior vena cava.


Renal cortical and hepatic phosphoenolpyruvate carboxylase in the diabetic rat: effect of acid-base status.


Achalasia of cricopharyngeus muscle and pharyngeal diverticulum.


Neoplasms in bladder diverticula.

Neoplasms in bladder diverticula.


Neoplastic diseases of the haematopoietic and lymphoid tissues. Systemic lymphosarcomas are common in all species of domestic mammal. A binomial classification of these tumours, based on both the anatomical form (i.e., distribution of lesions) and the type of cytology, is proposed. Mast cell tumours also are common, especially in the dog. The categories of lymphoid neoplasms described are: lymphosarcoma, lymphoid leukaemia, nodular lymphoid hyperplasia, tumours of the immunoglobulin-forming cells, and thymoma. The myeloid neoplasms described are: myeloid leukaemia, erythroleukaemia, acute erythraemia, polycythaemia vera, megakaryocytoid leukaemia, panmyelosis, myelosclerosis, and monocytoid leukaemia. Mast cell tumours are divided into mastocytoma and malignant mastocytosis.


Template specificity changes of DNA-dependent RNA polymerase in B. subtilis during sporulation.


Regulation of aromatic amino acid biosynthesis in higher plants. II. 3-Deoxy-arabino-heptulosonic acid 7-phosphate synthetase from cauliflower.


Regulation of rat liver glycogen synthetase. Evidence for a lysyl residue essential for glucose 6-phosphate activation.


Ambulatory management of tuberculosis.

Ambulatory management of tuberculosis.


Muscle blood flow in patients with ankle fracture.


Isoelectric focusing studies of staphylococcal epidermolytic toxin.


A policy for investment in biomedical research. Given a continuation of the current approach toward the managing and funding of research across the spectrum of disciplines basic to health, the country is headed for stultification and possible social disaster. Health care delivery should be considered as a science-based social industry and managed accordingly. Stability and adequate relation of the research effort to the industry's output should be sought. The establishment of a trust fund, derived as a percentage of health revenues, and of a public commission or a board of directors to provide expert advice on its expenditures are suggested.


"Killer" -lymphocytes in action? Light and electron microscopical findings in orthotopic liver homografts.


An olfactory area in the prefrontal lobe.


New lifestyle for the aged in a long-term hospital.


Alkaline phosphatase in auxiliary liver transplantation. Auxiliary liver allografts were inserted into baboons and allowed to undergo rejection. The incorporation of (14)C leucine into alkaline phosphatase was measured in both host and donor livers with the aid of an anti-alkaline phosphatase antibody. The results indicate that the increased serum alkaline phosphatase levels found under these circumstances are due to increased synthesis of the enzyme by both livers. Furthermore, it was shown that in the absence of biliary obstruction, this enhanced production of alkaline phosphatase is accompanied by an increase in the excretion of the enzyme into bile. It is suggested that the stimulus for the enhanced production of alkaline phosphatase is a substance which is normally produced in the liver and excreted into the bile.


Handling and disease problems of primates in Asia.


Gas-liquid chromatographic method for the analysis of carbaryl insecticide formulations.


Localization of breaks in human chromosomes induced by thio-TEPA in peripheral blood lymphocyte cultures at different times.


Cytologic and autoradiographic studies of the micronucleus at meiotic prophase in Tetrahymena pyriformis.


Serological evidence of cross infection in a dialysis unit hepatitis-B epidemic.


Development of a selective enterococcus medium based on manganese ion deficiency, sodium azide, and alkaline pH. Rogosa broth, without its salt supplement and dissolved in deionized water, was adapted for the selective isolation and enumeration of enterococci. This medium supported good growth of enterococci, but it suppressed growth of other lactic acid bacteria. The sensitivity and specificity of the medium were tested after addition of various increasing concentrations of NaN(3) against known strains of enterococci and other bacteria. Many strains of Streptococcus faecium showed low azide tolerance; optimal growth was obtained at a concentration of 0.01% NaN(3), which totally or partially inhibited unrelated species of lactic acid bacteria. The selectivity of the medium was further increased by pH adjustment to 9.6. Carbonate and Tween 80 were added to overcome partial inhibition of enterococcal growth by the new combination of selective conditions. The final medium was evaluated in agar form in isolations from human and animal feces, polluted water, meat, and dairy products. Counts were obtained after 16 to 17 h of incubation at 37 C. The isolates satisfactorily conformed to the group characteristics of enterococci.


Expulsion of Nippostrongylus brasiliensis from the small intestine of the rat by prostaglandin-like factors from ram semen.


Results of high dose radiation and surgery in the treatment of advanced cancer of the head and neck.


Simultaneous loss of proteinase- and lactose-utilizing enzyme activities in Streptococcus lactis and reversal of loss by transduction. During studies on spontaneous loss of lactose metabolism in Streptococcus lactis C2, it was found that the lactose-negative (lac(-)) mutants were also proteinase negative (prt(-)). This pleiotropic effect was observed in S. diacetilactis 18-16, but not in S. cremoris B1. The lac(-)prt(-) mutants from S. lactis C2 were able to grow in milk, but no pH change or measurable protein breakdown occurred. When the milk was supplemented with glucose, a slow decline in pH occurred. Addition of a protein hydrolysate to milk did not stimulate acid production. When both supplements were added to milk, normal growth and pH change were obtained. When the lac(-)prt(-) mutant of S. lactis C2 was transduced with the temperate phage from the lac(+)prt(+) parent culture, approximately equal numbers of lac(+)prt(-) and lac(+)prt(+) transductants were obtained. When the spontaneous lac(+)prt(-) strain of S. lactis C2 was converted to a lac(-)prt(-) derivative and transduced, similar results were obtained. The co-transduction of the lactose and proteinase markers suggest they are closely associated. The findings indicate that the transducing phage from S. lactis C2 can be used to examine the causes of instability in both the lactose and proteinase enzyme systems of this organism.


Serum and urinary levels of thyroid hormones in normal pregnancy.


Serum antibody in patients with mammary disease.


Serum proteins and plasma free amino acids in severe malnutrition.


Serum thyroxine (T-4) and triiodothyronine (T-3) uptake values in normal adult cats.


Automatic cell counting in continuous flow cultures of Tetrahymena pyriformis.


Traumatic esophageal pseudodiverticula in the newborn.


Enzymatic reduction of ribonucleotides: biosynthesis pathway of deoxyribonucleotides.


Estimation of serum thyrotropin (TSH) and stimulation with thyrotropin-releasing hormone (TRH) in thyroid diseases.


Chromatographic differences between circulating and pituitary thyrotropins.


Estimation of TBG by a competitive ligand-binding assay.


Chromatography of transforming deoxyribonucleic acid on methylated albumin and by gel filtration. 1. Native DNA from two strains of Bacillus subtilis was chromatographed by stepwise elution from MAK (methylated albumin on kieselguhr). 2. Transforming activity was confined to two out of the three main fractions, activity being distributed between the two peaks differently for DNA from the different strains. 3. Fractionation of DNA from both strains on 2% agarose gel gave two components. Approx. 75% of the material was eluted within the void volume of the column. Approx. 25% of the material consisted of degradation products of lower molecular weight. 4. Chromatography on MAK of the material of high molecular weight eluted from agarose gel gave a number of peaks differing in molecular weight, indicating that degradation of the DNA takes place during chromatography on MAK. 5. The distribution of transforming activity among the fractions from MAK suggests that degradation occurs preferentially in certain regions of the DNA.


Thrombocytolysis in gel.

Thrombocytolysis in gel.


Enzyme kinetics in cells.

Enzyme kinetics in cells.


The meaning of quality in medical care.

The meaning of quality in medical care.


The mechanism of hydromyelia in Chiari type 1 malformations.


Fragmentation and reduction of porcine 19 S immunoglobulin M.


Antimetabolites of coenzyme Q. Their potential application as antimalarials.


Dosimetric properties of the fast neutron therapy beams at TAMVEC.


Dynamics of cell populations in the olfactory epithelium.


Assimilation of the atlas and basilar impression: a review of 1,500 skull and cervical spine radiographs.


Spermidine biosynthesis during germination and subsequent vegetative growth of Bacillus megaterium spores. Spermidine biosynthesis was extremely low early in germination of Bacillus megaterium spores and the spermidine level remained constant. Rapid synthesis began after 130 min and thereafter accounted for the increase in spermidine level which began at this time. Biosynthesis was greatly (>84%) diminished by exogenous spermine or spermidine. Arginine and ornithine were both converted efficiently into spermidine, but arginine was the more immediate precursor as shown by isotope competition studies and by the absence of ornithine decarboxylase and the presence of arginine decarboxylase. Exogenous putrescine was not incorporated into spermidine, although it was taken up rapidly and degraded.


Vitamin E deficiency anemia in Old and New World monkeys.


The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin.


The molecular weight and properties of a neutral metallo-endopeptidase from rabbit kidney brush border. 1. Some properties of a brush-border neutral endopeptidase purified from rabbit kidney were investigated. The peptidase was assayed by its ability to hydrolyse [(125)I]iodoinsulin B chain. 2. The enzyme was found to be homogeneous when studied in the analytical ultracentrifuge and stained as a single glycoprotein band after electrophoresis in polyacrylamide gels. 3. The molecular weight was estimated by gel filtration in columns of Sephadex G-200, by polyacrylamide-gel electrophoresis in the presence of 2-mercapto-ethanol and sodium dodecyl sulphate and by sedimentation equilibrium in the ultra-centrifuge. The estimates fell within the range 87000-96000. The mean from two sedimentation equilibrium experiments was 93000, though this estimate may be slightly inflated because of the carbohydrate component of the enzyme. No evidence of dissociation into smaller subunits was obtained in the presence of thiol, sodium dodecyl sulphate or guanidine hydrochloride. 4. The endopeptidase was maximally active at pH6.0, although in phosphate buffer, which was strongly inhibitory, an optimum above pH8 was observed. 5. The enzyme was not affected by di-isopropyl phosphofluoridate nor by several thiol reagents. It was, however, strongly inhibited by many thiols and by EDTA and other chelating agents. 6. Although activity of the EDTA-treated enzyme could be partially restored by various bivalent metal ions, the optimum concentration for its reactivation by Zn(2+) was lower than that for other ions. This metal was detected in the enzyme preparation by atomic absorption spectrophotometry in an amount equivalent to approximately one atom/mol. 7. The enzyme is the only endopeptidase shown to be located in the kidney brush border and is the first mammalian example of a neutral Zn(2+)- activated endopeptidase to be characterized.


The morphological and clinical features of membranoproliferative glomerulonephritis in adults.


Chromosomal abnormalities in a patient with adolescent myelofibrosis.


A comparison of seven strains of Lactobacillus casei var. rhamnosus in relation to their use in the microbiological assay of serum folate.


A simple method for the primary isolation of Mycobacterium in a carbon dioxide atmosphere.


A simplified method for calculating dose-rate distributions from extended volumes containing gamma emitters.


A simple, disposable micro-flow drip regulator.


Eclampsia during the 16th gestational week.


Human galactose 1-phosphate uridylyltransferase. Absence of half-reaction activity of galactosemic proteins.


Human secretory component. I. Purification of free secretory component from colostrum.


An analysis by electron microscopy of intermediates in the replication of linear Tetrahymena mitochondrial DNA.


Coronary artery syndromes after sudden propranolol withdrawal.


Perinatal calf losses in a beef herd.

Perinatal calf losses in a beef herd.


The natural habitat of certain primates and the problem in obtaining them for laboratory experimentation.


The natural history of diabetes.

The natural history of diabetes.


Advances in research on brucellosis, 1957-1972.


Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.


Cylinder plate assay for lasalocid sodium.


An index for the judgment of optimal mating time in female cynomolgus monkeys (Macaca fascicularis).


Immune response to surface antigens of Staphylococcus aureus and their role in resistance to staphylococcal disease.


Immune competence of hereditarily asplenic mice.


Hardness of finger nails in well-nourished and malnourished populations.


Mating reaction and its daily rhythm in Euplotes crassus.


Meningococcal vulvovaginitis.

Meningococcal vulvovaginitis.


Widening of the paracellular pathway in the kidney tubule by a transtubular osmotic gradient. Passage of graded size non-electrolytes.


Techniques for overcoming problems of lipolytic enzymes and lipoxygenases in the preparation of plant organelles.


Retino-tectal course of optic nerves in cyclopic and synophthalmic zebrafish embryos.


Selenium in human plasma: levels in blood proteins and behavior upon dialysis, acidification, and reduction.


Immunochemical characterization of Naja naja siamensis toxin and of a chemically modified toxin.


Immunochemical comparisons of vertebrate glutamic acid decarboxylase.


Immunochemical method for detection of albumin in human meconium.


Immunoglobulins in acute leukemia in children.


Immunology and radiology.

Immunology and radiology.


Diagnostic electron microscopy of faeces. II. Acute gastroenteritis associated with reovirus-like particles. Virus particles resembling reoviruses or orbiviruses were found in the faeces of 40 of 73 patients under 6 years of age with acute gastroenteritis and in faeces of only two babies among 31 patients under 6 years admitted to hospital with other diagnoses. In morphology the particles resemble orbiviruses more closely than reoviruses, but differ in appearance from the orbiviruses in having a smooth, circular outline with a well marked continuous rim as seen in negatively stained preparations. They appear not to be serologically related to reovirus types 1, 2, or 3 and may be members of a new group.


Prognostic factors in the treatment of acute respiratory insufficiency with long-term extracorporeal oxygenation.


Parenteral nutrition.

Parenteral nutrition.


An interim report on osseous contour reconstruction using alloplastic materials and particulate bone grafting.


Mutants of Bacillus subtilis that excrete L-tryptophan. Communication I. Studies of the influence of several mutations in the genome of the revertants to histidine independence on the ability to excrete tryptophan.


An investigation into the presence of T strain mycoplasma in the male urethra.


Isoenzymes, multiple enzyme forms, and phylogeny.


Micro cell culture method for isolation of Chlamydia trachomatis. Presterilized mictotiter plates (96 wells) with BHK-21 cells on 5-mm cover slips were successfully used for cell culture isolation of trachoma from 15 infected conjunctival scrapings.


Microbial activation of prophenoloxidase from immune insect larvae.


Microbiologic aspects in patients with leukemia.


Microbiological studies on septicemic bullfrogs (Rana catesbeiana).


Dislocations of the ankle without fracture.


Microcephalic dwarfism in sisters.

Microcephalic dwarfism in sisters.


Photochemical activity and components of membrane preparations from blue-green algae. II. Low-temperature photooxidation of cytochrome b559.


Glucocorticoids and thyrotropin releasing hormone (TRH) secretion.


The odontogenic keratocyst--an approach to treatment.


Use of single radial immunodiffusion test for serological studies in volunteers inoculated with live attenuated influenza virus. Pre- and post-vaccination serum samples from 278 volunteers, who were given live influenza vaccines, were tested by haemagglutination inhibition (HI) and single radial immunodiffusion tests(SRDT) for antibody to influenza A/Hong Kong/1/68 (H3N2) virus envelope antigens. Those with high antibody titres detected in both tests were less frequently infected, and 85% of the 159 infected showed rises by HI and 70% by SRDT. Similarly, 69 pairs were tested for antibody to Hong Kong (N2) neuraminidase by neuraminidase inhibition test (NI) and by SRD tests. Those with high titres in both tests resisted infection and those who were infected showed a rise in antibody detected both by NI and SRD tests. In general, SRDT was less sensitive than HI and NI in detecting antibody and antibody rises, but in some volunteers it did detect antibody rises which were not detected by conventional tests. Because of its simplicity and speed it appeared to be of use in evaluating such vaccines.


Neurofibromatosis with renovascular hypertension. A case report.


Neurofibromatosis and congenital heart disease.


Biological deactivation of Rg seed dressing in soil.


Biological properties of surface components of Listeria monocytogenes (Ei factor).


Biologically active components of the cells of gram-positive bacteria.


Thyroglossal cysts and fistulae.

Thyroglossal cysts and fistulae.


Haemoglobin G St. José in an Italian family.


Radioimmunoassay of thyrotropin-releasing hormone (TRH) in human plasma and urine.


Thyroid tumors.

Thyroid tumors.


Histological studies on the follicles with special reference to their atresia in Egyptian buffaloes.


A biometric study of three strains of Tetrahymena pyriformis (Ciliatea: Hymenostomatida).


"Incomplete subserotypes" and the cryptic axial filament antigen of Leptospira.


Seasonal prevalence of avian hematozoa in passeriform birds of Atlantic Canada.


Pulmonary abnormalities in sepsis.

Pulmonary abnormalities in sepsis.


Pulmonary emphysema and alpha1-antitrypsin deficiency.


Pulmonary host defenses in rabbits after immunization with Pseudomonas antigens: the interaction of bacteria, antibodies, macrophages, and lymphocytes.


Preponderance of gram-positive infections during parenteral alimentation.


A spondyloepiphyseal dysplasia with peripheral dysostosis.


Pyelonephritis transferred by parabiosis.


Prolonged extracorporeal cardiopulmonary support in man.


Lesions in the cells of proximal convoluted tubules in rat kidney induced by amanitin-albumin conjugate.


Response patterns of primary vestibular neurons to thermal and rotational stimuli.


Oligonucleotides and the quaternary structure of gene-5 protein from filamentous bacteriophage.


Histopathology and ultrastructure of cartilage in the chondrodystrophies.


Isotope techniques for studying the dynamics of nitrogen metabolism in ruminants.


Postoperative oral and intravenous nutrition. Oral and intravenous high calorie-amino acid nutritional therapy postoperatively resulted in significant weight gain, improved colonic wound healing and maintenance of normal intravascular albumin levels. Provision of caloric needs without amino acids minimized weight loss postoperatively. However, infusion of hypertonic dextrose solutions resulted in severe generalized hepatic fatty infiltration and marked hypoalbuminemia. Protein and calorie deprivation by administration of 5% dextrose and water resulted in the greatest postoperative weight loss, reduced intravascular albumin levels and decreased colonic anastomotic strength. Comparison of oral and intravenous diet administration demonstrated that hypertonic dextrose infusion was markedly deleterious to hepatic morphology and serum protein metabolism in normal rats. Further clinical investigation appears indicated in previously well-nourished patients undergoing extensive surgery who will not be able to ingest adequate nutrients in the postoperative period.


Cricopharyngeal achalasia.

Cricopharyngeal achalasia.


Pathophysiology of vitamin E deficiency in monkeys.


Genioplasty with reference to resorption and the hinge sliding osteotomy.


The order of replication of chromosomal markers in Pseudomonas aeruginosa strain 1. I. Marker frequency analysis by transduction.


Restoration of deficient edentulous ridges by bone grafting and the use of subperiosteal metal implants.


Editorial: Malnutrition in the hospital.


Editorial: Sarcoidosis and tuberculosis.


Photoreactivation, photoproduct formation, and deoxyribonucleic acid state in ultraviolet-irradiated sporulating cultures of Bacillus cereus. Photoreactivation of ultraviolet-irradiated Bacillus cereus T declined markedly during the development of stage IV forespores. During ultraviolet irradiation of a culture containing early and late stage IV forespores, both vegetative- and spore-type photoproducts were formed. The formation of vegetative-type photoproducts (mainly thymine dimers) decreased to nearly half during late stage IV, remaining constant until lysis of the mother cells began, when it fell to zero. Spore-type photoproducts were first observed during late stage IV and increased with the increase in numbers of late stage IV forespores. The occurrence of spore-type photoproducts preceded the development of refractile forespores by about 1 h. At stage III the nuclear material occupied a central position, and the ribosomes were at the periphery of the forespore protoplast. During stage IV the deoxyribonucleic acid (DNA) occurred in a peripheral position, and bundles of fibers ("transition" DNA) could be seen. By stage V, all of the DNA appeared to be of the spore type and was peripheral, and the forespore protoplast center was packed with ribosomes. Forespore stages II, III, and IV were classified by light and electron microscopy. The curve for electron microscope classifications preceded that for light microscope classifications by approximately one stage. The formation of spore-type photoproducts preceded differentiation of DNA by about 1 h, the latter coinciding with the development of refractility. Spore-type photoproducts have been associated with DNA in the A state, and the progressive change of the forespore DNA into this state is discussed in relation to the spore differentiation process.


Editorial: The management of diabetic acidosis.


Editorial: The threat of gastro-intestinal infections in Lebanon.


Editorial: There is more to health than just paying bills.


Conformational properties of some viral DNAs.


Factors in human serum promoting phagocytosis of Pseudomonas aeruginosa. I. Interaction of opsonins with the bacterium.


Factors in human serum promoting phagocytosis of Pseudomonas aeruginosa. II. Interaction of opsonins with the phagocytic cell.


Factors in the mechanism of persistence of viral infections.


Formosan monkey (Macaca cyclopis): present situation in Taiwan and its reproductive biology.


Glucose uptake and phosphorylation in Pseudomonas fluorescens. Pseudomonas fluorescens ATCC 13525 and a particulate glucose oxidase (d-glucose:oxygen oxidoreductase, EC 1.1.3.4) mutant of this organism, gox-7, were examined to determine if glucose oxidation via particulate glucose oxidase is a required first step for glucose uptake. Initial [(14)C]glucose-uptake rates in parent and gox-7 cells were qualitatively similar. Initial [(14)C]glucose-uptake product analysis revealed that glucose was accumulated via active transport and was rapidly metabolized to glucose-6-phosphate and gluconate-6-phosphate in both parent and gox-7 cells. Cell extracts contained soluble adenosine 5'-triphosphate specific kinase activity for phosphorylation of glucose. Glucose uptake was induced by glucose and not gluconate, thus, establishing independent regulation of glucose transport and glucose catabolism in p. fluorescens. The results prove that glucose oxidase was not an obligatory reaction for glucose carbon permeation in P. fluorescens. A general unifying scheme for glucose utilization in the aerobic fluorescent pseudomonads is suggested for the purpose of clarifying glucose uptake in these bacteria.


Glycosidases with unusual specificities. IV. A hydrolase that splits p-nitrophenyl-2-deoxy-2-glycylamido-beta-D-glucopyranoside: properties of the purified enzyme.


Disposition of SCH 10595 in animals and man.