Metabolism of ethanol and fructose in the perfused rat liver.


Local inhibition of mastocalcergy by calciphylactic challengers.


Clinical significance of rheumatoid vasculitis and the incidence of digital vascular lesions.


Bacteriology of urinary tract infections. I. A quantitative bacteriologic study with antibiotic sensitivity of the strains isolated.


Hexuronic acid dehydrogenase of Agrobacterium tumefaciens. Growth of Agrobacterium tumefaciens on d-glucuronic acid (GlcUA) or d-galacturonic acid (GalUA) induces formation of hexuronic acid dehydrogenase [d-aldohexuronic acid: nicotinamide adenine dinucleotide (NAD) oxidoreductase]. The dehydrogenase, which irreversibly converts GlcUA or GalUA to the corresponding hexaric acid with the concomitant reduction of NAD, but not of nicotinamide adenine dinucleotide phosphate was purified 60-fold by MnCl(2) treatment, (NH(4))(2)SO(4) fractionation, chromatography on diethylaminoethyl Sephadex and negative adsorption with Ca(3)(PO(4))(2) gel. The pH optimum is 8.0. Other uronic acids, aldohexoses, aldopentoses, and polyols, are not substrates. Reduced nicotinamide adenine dinucleotide is an inhibitor strictly competitive with NAD. Kinetic data indicate that the dehydrogenase induced by growth on GlcUA may not be identical with that induced by growth on GalUA.


Mode of nicotinamide adenine dinucleotide utilization by Escherichia coli. Exogenous nicotinamide adenine dinucleotide is not utilized per se by Escherichia coli, but is converted to nicotinamide and thence to nicotinamide adenine dinucleotide via nicotinate.


Role of divalent cations in the action of polymyxin B and EDTA on Pseudomonas aeruginosa.


Persistent jaundice. Résumé of case.

Persistent jaundice. Résumé of case.


Association of maternal genital herpetic infection with spontaneous abortion.


The effect of light and darkness on lactic acid content of the pineal gland.


Studies on the mitochondrial electron transport system in Aspergillus.


Radiation inhibition of peritoneal adhesions: an experimental study.


A trypsin technic for the preparation of isolated rat anterior pituitary cells.


Species source of complement in viral-immune and other cytolytic reactions.


Heterocyclic thiosemicarbazones: correlation between structure, inhibition of ribonucleotide reductase, and inhibition of DNA viruses.


Isolation of viruses from primary dog cell cultures and the occurrence of viral antibody in donor animals.


Method for chromosome preparation from mouse peripheral lymphocytes.


A generalized infection of newborn hamsters with type 2 adenovirus.


Immunogenicity of rhinoviruses.

Immunogenicity of rhinoviruses.


Inhibition of poliovirus by effect of a methylthiopyrimidine derivative.


Alpha-glycerophosphate dehydrogenase inhibition in rat heart and adipose tissue.


Comparison of antigens from human and chimpanzee herpes-type virus-infected hemic cell lines.


Studies of hamster-specific oncogenic virus derived from hamster tumors induced by Kirsten murine sarcoma virus.


Sialographic study of diseases of the major salivary glands.


Attempts at isolation of lymphocytosis-producing factor from supernatant fluids of Bordetella pertussis cultures.


Feline viruses: isolation, characterization, and pathogenicity of a feline reovirus.


Pathogenesis of canine herpesvirus encephalitis.


Biological and physicochemical properties of ground squirrel cytomegalovirus.


Inhibition of foot-and-mouth disease virus by normal bovine serum.


Aqueous humor penetration of several antibiotics in the dog.


Hereditary methemoglobinemia, toxic methemoglobinemia and the reduction of methemoglobin.


Clinical aspects of drug reactions in hereditary hepatic porphyria.


Atypical human liver alcohol dehydrogenase.


Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa. 1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol (RO 7-0582) and 2-methyl-5-nitroimidazole-1-ethanol (Metronidazole), substances known to be potent trichomonacides, were shown to inhibit obligate anaerobic bacteria in vitro but were essentially without effect at the doses tested against bacteria capable of growing aerobically. A similar effect was noted in vivo in that both substances exhibited good chemotherapeutic activity against infections produced by three species of anaerobic protozoa but were essentially inactive at the doses tested against three species of aerobic protozoa.


Effect of mixed cultures on antibiotic susceptibility testing. Careful studies of the antibiotic susceptibilities of mixtures of bacteria likely to be encountered in clinical cultures have shown that the results obtained are completely unreliable. Mixtures of resistant and sensitive species appeared either as "resistant" or "sensitive" depending upon the organisms and the drug. A number of sensitive species gave reactions interpreted as resistant when tested in combination. Since reactions of bacterial mixtures are completely unpredictable, the authors emphasize that antibiotic susceptibility testing be limited to pure cultures.


Interferon production by human leukocytes in vitro: some biological characteristics. Interferon was optimally produced in human peripheral leukocyte cultures incubated for approximately 19 hr in the presence of Sendai virus at a multiplicity of 10 to 50 EID(50)/cell. For determining whether deoxyribonucleic acid (DNA) synthesis per se was essential for interferon production, 1-beta-D-arabinofuranosylcytosine (Ara-C), a potent DNA inhibitor was studied for its effect on interferon production in leukocytic and bone marrow cell cultures. These cells showed no impaired capacity to produce interferon when treated with 15 mug of Ara-C per ml. Interferon yields were also determined in leukocyte cultures treated with actinomycin D (0.1 mug/ml) and puromycin (10 mug/ml) at various times before and after virus inoculation. The data suggested that sequential transcriptive and translational events were required for the de novo synthesis of interferon by the infected leukocytes, in a manner similar to other known virus-induced interferon-producing systems. The synthesis of macromolecules and the effects of antimetabolites in leukocytes and bone marrow cell cultures were followed by measuring the incorporation of thymidine-2-(14)C, uridine-5-(3)H, and L-phenylalanine-1-(14)C. The effect of 0.1 mug of actinomycin per ml on the capacity of leukemic leukocytes to produce interferon was also studied. Preliminary data showed that, in contrast to nonleukemic leukocytes, interferon production by leukemic leukocytes was only partially inhibited by actinomycin.


Growth, sporulation, and germination of Clostridium perfringens in media of controlled water activity. Requirements in terms of water activity (a(w)) for the growth, sporulation, and germination of Clostridium perfringens were determined. Strain A48 was used in all phases, and in addition either NCTC 8239 or NCTC 8797 was used for growth, sporulation, and germination studies. The desired a(w) of the test media was obtained by the addition of one of three solutes: glycerol, sucrose, or sodium chloride. The freezing point depression method was used to determine the a(w). The basal medium for growth and germination was Fluid Thioglycollate Medium. It had an a(w) of 0.995 and produced maximum growth and fastest growth rate among the six levels of a(w) tested. The lowest a(w) supporting growth and germination of C. perfringens was between 0.97 and 0.95 in the test media made with sucrose or sodium chloride and 0.93 or below in the test media adjusted with glycerol. Spore production by C. perfringens in Ellner's or modified medium required a higher a(w) than growth.


Production of interferon in serum-free human leukocyte suspensions. The recovery of interferon from Sendai-infected suspensions of purified human leukocytes is dependent on the serum concentration in the incubation medium. Very little interferon is obtained from serum-free suspensions. The data reported demonstrate that the critical macromolecular, age-independent, and species-unspecific serum principle can be omitted from the suspensions if the medium is supplemented with a combination of crystalline serum albumin and high concentrations of any one of five studied dipolar ionic buffers [N,N-bis(2-hydroxyethyl) glycine (Bicine), N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES), 2-(N-morpholino)ethanesulfonic acid (MES), N-tris(hydroxymethyl)methyl-2-amino-ethanesulfonic acid (TES), and N-tris(hydroxymethyl)methylglycine (Tricine)]. The optimal combination [TES (1.0%, w/v) and bovine serum albumin (0.8%, w/v)] allows the production of potent preparations of serum-free human interferon.


Effectiveness of acetic acid, betadine, amphyll, polymyxin B, colistin, and gentamicin against Pseudomonas aeruginosa. The in vitro effectiveness of three germicides and three chemotherapeutic drugs against hospital-isolated strains of Pseudomonas aeruginosa was determined. Solutions of 1% acetic acid, 0.5% Amphyll, and 0.1% Betadine were bactericidal for six strains tested within 15 min at room temperature. Over a 3-year period at the Albany Medical Center Hospital, the percentages of strains of P. aeruginosa susceptible to polymyxin B, colistin, and gentamicin did not increase. During this 3-year period, polymyxin B and colistin were administered at the hospital but gentamicin was not.


Rapid plaque assay for encephalomyocarditis virus. A liquid overlay plaquing technique is described which offers a rapid and simple plaque assay system for small plaque variants of encephalomyocarditis virus.


Effect of prehumidification on sampling of selected airborne viruses. Studies were undertaken to determine if a prewetting device (humidifier bulb) used in combination with an all glass impinger (AGI-30) would increase the recovery of airborne mengovirus-37A, vesicular stomatitis virus (VSV), and the S-13 coliphage. Suspensions of T3 coliphage with mengovirus-37A, VSV, or S-13 were aerosolized and collected by using the AGI-30-humidifier bulb combination to sample the aerosols before and after shifts in relative humidities (RH). These studies revealed the following. (i) At low RH values there was a 3 to 4 log increase in recovery of airborne T3 phage; (ii) concomitantly, the recovery of mengovirus-37A and VSV decreased; and (iii) only at the mid-range RH values was the recovery of S-13 enhanced. The prehumidification technique significantly increased the recovery of airborne T3 phage but decreased the recovery of the two animal viruses tested.


Quantitation of tail lesions in vaccinia-infected mice. When mice were infected with vaccinia virus via the tail vein, the number of lesions was influenced by the injection site. A site 3 cm from the base of the tail is of greatest practical value.


The isolation and characterization of the plasma membrane from chick embryo fibroblasts.


The control of fatty acid composition in glycerolipids of the endoplasmic reticulum.


Blood sugar, serum insulin and free fatty acid interrelationships during intravenous tolbutamide testing in normal young adults and in patients with insulinoma.


Cortical influence on single neurons of the lateral reticular nucleus of the cat.


Characteristic features of augmenting and recruiting responses in the cerebral cortex.


Depression of centrum medianum complex response by rostral thalamic lesion.


A study of pituitary and adrenal function in patients with traumatic injuries of the spinal cord.


Variability of herpes simplex virus: isolation of two variants from simultaneous eruptions at different sites.


Prospects for the use of double-stranded ribonucleic acid (poly I:C) inducers in man.


Multisystem blood group study in trophoblastic disease.


Methylcholanthrene-induced hormonally active ovarian tumors in rabbits after two years of experimenting.


Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum. Cyclic AMP, which is a cell attractant (acrasin) for Dictyostelium discoideum, will cause isolated, unaggregated cells to turn directly into stalk cells containing thick celluloselike walls and large vacuoles. From previous work we know that in the cell mass, acrasin is produced solely in the region of stalk formation during fruiting, that stalk formation involves a high level of catabolism, and that cyclic AMP stimulates catabolic enzymes in other systems. These facts obviously suggest that in the development of D. discoideum, cyclic AMP might be a key factor in stalk cell differentiation.


Mechanism of action of 2-mercapto-1(beta-4-pyridethyl)benzimidazole: a reversible inhibitor of interferon activity. 2-mercapto-1(beta-4-pyridethyl)benzimidazole (MPB) inhibited the development of antiviral activity induced by interferon in chick cells. The MPB effect was reversed by washing the cells. The action of MPB was on a step immediately following interferon binding but before the cellular RNA and protein synthesis that appear to be required for interferon action. The step blocked by MPB possibly involves cellular phospholipid synthesis.


Electron spin resonance studies of lipid-protein interaction in human serum lipoproteins. Spin-labeled derivatives of high density (HDL) and low density (LDL) lipoproteins from human serum were prepared with N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)-maleimide. At the low ratios of spin label to protein employed, no changes in circular dichroism or immunochemical reactions were detected. The lipoprotein derivatives, labeled in their protein moieties, exhibited electron spin resonance spectra containing signals of strongly immobilized and weakly immobilized components. The strongly immobilized component was relatively more prominent in high density than in low density lipoproteins. Delipidation or addition of detergent greatly reduced the relative magnitude of the highly-immobilized signal. Reaction with specific antibodies did not alter the signals of spin-labeled lipoproteins or apoproteins. The signals of the reconstituted complex of spin-labeled apoHDL-phospholipid were indistinguishable from those of a spin-labeled apoHDL in the absence of lipid.


A study on the transcription of the polyoma viral genome. The transcription of polyoma (Py) viral RNA was studied in primary mouse kidney cell cultures (a) during normal, asynchronous infection, (b) under conditions where Py-induced DNA synthesis was inhibited with 5-fluorodeoxyuridine, and (c) after the synchronized onset of Py-induced DNA synthesis. The results obtained suggest that the bulk of Py RNA transcribed after the (asynchronous or synchronized) onset of Py-induced DNA synthesis, designated as "late" Py RNA, corresponds to the polycistronic transcript of most or all of the genetic information contained in a strand of circular Py DNA. The rate at which late Py RNA is transcribed is related to the amount of free Py DNA present in the cultures. Py-infected cultures contain a second, minor component of Py RNA (of one or possibly more species), designated as "early" Py RNA. At least some of this RNA continues to be transcribed if Py-induced DNA synthesis is inhibited with 5-fluorodeoxyuridine and, possibly, also late during normal infection.


Parathyroid hormone, 3'5' AMP, Ca++, and renal gluconeogenesis. Isolated segments of renal tubules prepared from rat kidney cortex were capable of sustained rates of gluconeogenesis when lactate served as substrate. An increase in external Ca(++), or the addition of parathyroid hormone at a fixed Ca(++) concentration led to enhanced rate of gluconeogenesis. However, parathyroid did not increase gluconeogenesis in the absence of external Ca(++) even though it caused a rise in 3'5' AMP whether Ca(++) was present or absent. Metabolite profiles showed that either an increase in external Ca(++), or the addition of hormone in the presence of calcium led to qualitatively very similar changes. However, the addition of hormone had little effect upon metabolite levels in the absence of extracellular calcium even though an increase in extracellular H(+) enhanced gluconeogenesis under similar conditions. These results are discussed in relationship to the close association of 3'5' AMP and Ca(++) in a variety of cellular systems.


Trans-species rescue of defective genomes of murine sarcoma virus from hamster tumor cells with helper feline leukemia virus. This report describes a trans-species rescue of defective MSV genome with helper leukemia virus derived from cats. This rescue was achieved by in vitro co-cultivation of hamster tumor cells with feline embryo cells in the presence of helper feline leukemia virus (FeLV), or by inoculation of tumor cells into FeLV-infected newborn cats. The rescued focus-forming viruses produced foci in feline embryo cultures but not in cultures of mouse, rat, and hamster species. One isolate was tested and found to induce sarcoma in a kitten. Antigenic and viral interference studies indicated that the focus-forming virus has the viral envelope of FeLV. Virus stocks consisted of a mixture of focus-forming particles and a 1000-fold excess of helper FeLV. Virus assay pattern in feline embryo cultures with or without added helper FeLV indicated that this helper virus is required for the transformation of feline cells.


Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver. An increase in the perfusate glucose concentration from near zero to about 11 mM increased glycogen synthesis in the perfused, isolated rat liver from zero to a value about half the maximum seen in the intact animal. Increased synthesis appeard to due not only to provision of substrate but also to conversion of glycogen synthetase to the active form and of glycogen phosphorylase to the inactive form. These glucose effects, which are apparently independent of changes in levels of hormones or adenosine 3':5'-cyclic phosphate, may be physiologically significant for control of the blood glucose level.


Structural studies on reovirus: discontinuities in the genome. The double-stranded RNA genome of reovirus breaks reproducibly into ten segments upon extraction from purified virions. Reovirus-induced messenger RNA's formed in infected cells correspond in length to these ten genomic segments and some real structural and biological implication must be accorded to the ready manner in which the genome is fragmented on attempted isolation. In the present work we have posed the question whether the reovirus genome is a continuous, double-stranded molecule or whether there are discontinuities in the complementary strands of RNA that might constitute "weak points" in the structure. To answer this question, a method was developed to estimate the 3'-terminal nucleosides of RNA within intact virions. Approximately as many 3'-ends are free inside the virion as in RNA extracted from purified virus. Thus, the viral genome exists as a discontinuous structure inside the virus particle and both strands of the duplex are interrupted at intervals.


Effect of thyrocalcitonin on adenosine 3':5'-cyclic phosphate formation by rat kidney and bone. Thyrocalcitonin (TCT) increased the rate of accumulation of adenosine 3':5'-cyclic phosphate (cyclic AMP) when added to incubations containing washed particles from whole rat kidney, adenosine triphosphate (ATP), MgSO(4), and caffeine. The maximum stimulatory effect of TCT, 44 +/- 6.7 per cent, was always less than the 150 to 250 per cent increase produced by parathyroid hormone (PTH). The effect of both hormones together was no greater than that of PTH alone when each was present at a maximally effective concentration. Since neither TCT nor PTH altered the rate of degradation of cyclic AMP by the kidney preparation, it may be inferred that their effects on cyclic AMP accumulation are the result of increased formation of cyclic AMP. Adenyl cyclase activity in homogenates of renal cortex was stimulated to a greater extent by TCT and PTH than was that of medulla, whereas, as reported earlier, the effect of vasopressin was much larger with homogenates of medulla. The accumulation of cyclic AMP in incubations of rat kidney cortex slices was increased 20 to 60 per cent by TCT and 50 to 140 per cent by PTH. The accumulation of cyclic AMP in incubations of rat calvaria was increased about threefold with TCT and nine to tenfold with PTH, while reduced and alkylated TCT had less than 10 per cent of the activity of TCT. These observations are consistent with the view that the physiological effects of TCT and PTH in kidney and bone are secondary to the enhanced formation of cyclic AMP.


Deviant illness behaviour: patients of mesmerists.


Inhibition of hormone-sensitive adenyl cyclase by phenothiazines. Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these conditions. At chlorpromazine concentrations >3 x 10(-4)M F(-)-stimulated cyclase activity of thyroid and adrenal tissue was increased. Other phenothiazines, trifluoperazine, and prochlorperazine, have similar effects on thyrotropin and F(-)-stimulated cyclase activity of thyroid. Na(+)- K(+)-dependent ATPase of thyroid is also inhibited by chlorpromazine. Since thymol causes a similar dissociation of hormone- and F(-)-stimulated adenyl cyclase, it is concluded that the surface properties of these agents best account for their effects on adenyl cyclase.


Host parasite relationships of chimpanzee viruses. ARL-TR-69-9.


Discussion: the nature of the Le-a and Le-b antigens in human plasma.


The effect of sodium hypochlorite on Ascaris eggs and cysts of Entamoeba histolytica.


Concentration of viruses from sewage and excreta on insoluble polyelectrolytes. The concentration of viruses from sewage by adsorption on and elution from an insoluble cross-linked copolymer of maleic anhydride is described. Viruses either added to sewage or naturally contained in sewage were preferentially adsorbed to this polyelectrolyte at a pH range of 5.0 to 6.0 and were eluted at pH 8.0 to 9.0. In a 2-month survey of viruses in sewage in the spring (April to May 1968), when viruses are at low levels, efficient and economical detection of these agents was accomplished with the polyelectrolyte-concentration method. This method lends itself to the detection of viruses present in minute amounts in fecal samples, urine, sewage, and other natural waters. Large volumes of these fluids can be treated with the polymer described, and virus can be concentrated sufficiently for detection.


VERO cells (Cercopithecus aethiops kidney)--growth characteristics and viral susceptibility for use in diagnostic virology. (Brief report).


Survival of human pathogens in composted sewage. Studies were conducted to assess the effectiveness of an aerobic composter in destroying pathogens that may possibly be present in raw sewage sludge. Experiments conducted in this study were designed to determine whether or not selected indicator organisms (i.e., Salmonella newport, poliovirus type 1, Ascaris lumbricoides ova, and Candida albicans) could survive the composting process. The results of the assay showed that after 43 hr of composting, no viable indicator organisms could be detected. The poliovirus type I was the most sensitive, being inactivated within the first hour, whereas C. albicans was the most resistant, requiring more than 28 hr of composting for its inactivation. The data from this study indicated that aerobic composting of sewage sludge would destroy the indicator pathogens when a temperature of 60 to 70 C is maintained for a period of 3 days.


Dynamic aspects of sleep disturbance in relation to mental illness.


An analysis of the electron spin resonance of low spin ferric heme compounds. The electron spin resonance spectra of low spin ferric heme proteins are calculated and compared with experimental spectra recently obtained for a large number of heme proteins. On the basis of observed g values, these heme proteins have been categorized into five prototypes. Since electron spin resonance spectra are quite sensitive to small changes in the local environment about the paramagnetic ion, we have explored in some detail, the possibility that the g value variation in these different types of proteins is due to systematic environmental changes. To this end, we have calculated the g values as a function of tetragonal and rhombic distortions and compared our results with observed behavior. In addition we have also calculated the energy intervals between the low spin states in zero magnetic field and the temperature dependent magnetic moments and studied the effect on these properties also of small symmetry changes.


Adenovirus infections in Manitoba.

Adenovirus infections in Manitoba. This review of adenovirus infections in Manitoba over a five-year period is introduced with a brief presentation on the structure-function relationships of the adenoviruses. Extensive research has resulted in the accumulation of a great deal of basic information, far surpassing our knowledge about the infections that these viruses produce in man. More research is needed on the epidemiological and clinical aspects of these diseases, including methods for prevention and treatment, and earlier methods of diagnosis.Features of 216 adenovirus respiratory infections diagnosed from 1963 to 1967 are reviewed and presented. All infections were diagnosed by showing a four-fold or greater increase. In addition, an adenovirus was isolated from many of the infections. These infections occurred every year in substantial numbers and they were seen during each month of the year, although they were more frequent and severe in the winter. Infants and younger persons were often affected. The most severe disease was a pneumonitis which occurred mainly in infants. Associated symptoms usually arose from the gastrointestinal tract, and were sufficiently common to indicate that one should suspect an adenovirus infection when respiratory and gastrointestinal symptoms occur together in a child.The possible role of adenoviruses in the etiology of other than respiratory diseases is discussed and the features of 96 possible non-respiratory infections are presented. Further work will be required to establish a definite etiologic role of the adenoviruses in most of these infections.


Combined irradiation modalities in the therapy of malignant lymphoma with chylothorax. Case report.


A progeria-like syndrome produced by dihydrotachysterol: its prevention by conjugated estrogens (Premarin).


Review of results in a geriatric intensive treatment unit: some prospects.


Clinicopathologic conference: hepatic failure with clonorchiasis.


Benign vaginal tumor coexistent with squamous-cell carcinoma in situ of cervix.


Ultrastructure of cortical synapses after failure of presynaptic activity in ischemia.


A possible mechanism for the erythrocytosis associated with hepatocellular carcinoma in man.


Effect of phytohemagglutinin on enzymes of thymidine salvage pathway of cultured chronic lymphatic leukemic lymphocytes.


A new virus of minimal pathogenicity associated with Friend virus. II. Histological changes and immunodepressive effect.


The distribution of the mouse mammary tumor agent and its antigenicity in milk.


Transformation of hamster cells in vivo and in vitro by an adenovirus 4-SV40 hybrid.


Monkey-mouse hybrid cell lines containing the SV40 genome in a partially repressed state.


The pattern of protein synthesis in SV40-infected CV-1 cells.


Structural proteins of murine erythroblastosis virus.


A new virus of minimal pathogenicity associated with Friend virus. I. Isolation by end-point dilution.


Cystic and pseudocystic lesions of the terminal phalanx with special reference to epidermoid cysts.


Genetic modes of transmission in metabolic bone disease.


Fourteenth Bowditch lecture. Blood-borne signals. The measuring and modelling of humoral communication and control.


Microbiological aspects of radiopasteurized chicken. NYO-3733-4.


Microbiological aspects of radiopasteurized chicken. NYO-3733-7.


Microbiological aspects of radiopasteurized chicken. NYO-3733-5.


Microbiological aspects of radiopasteurized chicken. NYO-3733-6.


Microbiological aspects of radiopasteurized chicken. NYO-3733-3.


Bone age in short boys and tall girls.

Bone age in short boys and tall girls.


Epidemiology of primary central nervous system neoplasms. I. Mortality from primary central nervous system neoplasms in Minnesota.


Antigenic characterization of parainfluenza 4A and 4B by the hemagglutination-inhibition test and distribution of HI antibody in human sera.


Antigenic segregation of type 2 poliovirus isolants related and unrelated to Sabin's vaccine strain with modified Wecker technique.


Cytomegalovirus isolations associated with pregnancy wastage.


The use of multivariate techniques in the study of skeletal populations.


Genital herpesvirus (type II) strain differences.


Paleodemography of India and Ceylon since 3000 B.C.


Approaches to the study of developmental variability in human skeletal populations.


Paleodemography and evolution.

Paleodemography and evolution.


Nutritional stress and growth: sex difference in adaptive response.


Neutralizing antibody in experimentally induced respiratory infection in calves.


Bluetongue virus in white-tailed deer.

Bluetongue virus in white-tailed deer.


Marek's disease: application of immunofluorescence for detection of antigen and antibody.


Lipid utilization in polyoma virus-infected mouse embryo cells.


Granular cell myoblastoma of the bronchus. Long-term follow-up after its local resection.


Milker's nodule. A clinical and electron microscopic report.


Death and transfiguration of a problem.

Death and transfiguration of a problem.


The biochemistry and pharmacology of the D-state (dreaming sleep).


Drugs and dreams. IV. Tranquilizers and their effects upon dreams and dreaming in schizophrenic patients.


Some considerations of motor and electrical activity in states of diminished awareness.


Micromethods for respiratory virus sero-epidemiology.


Effect of prolonged incubation on untyped enteroviruses.


Studies of variola virus and immunity in smallpox. I. Variola virus hemagglutinins.


Observations on childhood infections with the Epstein-Barr virus.


Equine interferon: characterization of a viral inhibitor induced in equine kidney cell cultures with statolon.


Hepatitis in marmosets.

Hepatitis in marmosets.


Neurologic abnormalities complicating severe renal disease.


Unitary multiple-spiked responses in cat inferior olive nucleus.


Long inhibitory and excitatory pathways converging onto cat reticular and Deiters' neurons and their relevance to reticulofugal axons.


Discrimination of different spinal monosynaptic pathways converging into reticular neurons.


Renshaw cell mediated inhibition of Renshaw cells: patterns of excitation and inhibition from impulses in motor axon collaterals.


Transfer characteristics of excitation and inhibition in cat retinal ganglion cells.


Transfer characteristics of excitation and inhibition in the human visual system.


Enzyme histochemistry of the normal and atherosclerotic canine aorta.


Electrophysiological evidence for a mossy fiber input to the cerebellar cortex activated indirectly by collaterals of spinocerebellar pathways.


An evaluation of 10 years' experience with retroperitoneal lymph node dissection for Wilms' tumor.


Hospital-acquired herpes zoster following exposure to chickenpox.


Microangiopathic hemolytic anemia with recovery after removal of a huge leiomyoblastoma.


Viral infections in a large urban hospital.


Neurotrophic control of protein synthesis in the regenerating limb of the newt, Triturus.


Active water-insoluble derivative of renin.


Self-annealing of subgroup 2 myxovirus RNAs.


Positive alpha-1-foetoprotein tests in pyridoxine deprived baboons: relevance to liver carcinoma in Africans.


Delta-aminolevulinic acid synthetase: induction in embryonic chick liver by glucagon. Glucagon elicits a twofold increase in delta-aminolevulinic acid synthetase activity in the livers of 18-day-old chick embryos. This rise occurs when RNA synthesis is inhibited, but is prevented when protein synthesis is blocked. Cyclic adenosine monophosphate appears not to be involved.


Preparation of beating heart cells from adult rats. Suspensions of cardiac cells have been prepared from fragments of hearts from adult rats by prolonged incubation with trypsin and collagenase. In these preparations, about 50 percent of the viable cells routinely exhibit spontaneous contractions ranging from 20 to 120 beats per minute at room temperature. The contractile activity is essentially lost at 2 degrees C but returns to normal as the temperature is increased. The rate of cellular contractions and the percentage of total cells exhibiting contractility are influenced by experimental conditions of cell preparation and the composition of the suspending medium.


Intestinal enzymes: indicators of proliferation and differentiation in the jejunum. Some intestinal enZymes were assayed which were related to: (i) Cellular proliferation, for example, aspartate carbamoyltransferase, thymidine kinase, uridine kinase, and dihydroorotase; (ii) cellular differentiation, for example, lactase, invertase, maltase, alkaline phosphatase, and dipeptidase; and (iii) lysosomes, for example, beta-glucuronidase, acid beta-galactosidase, and acid phosphatase. These enzymatic determinations can be used to distinguish the crypt from the villus during healthy or diseased states.


Benign mesenchymoma.

Benign mesenchymoma.


Alveolar cell carcinoma.

Alveolar cell carcinoma.


Treatment of the Wilms' tumor with actinomycin D.


Potentially infectious agents associated with shearling bedpads. I. Effect of laundering with detergent-disinfectant combinations on polio and vaccinia viruses. Glutaraldehyde-tanned woolskin pads which are used for the prevention of decubitus ulcers in bed patients were experimentally contaminated with polio or vaccinia viruses. Two methods of exposure, direct contact and aerosol, were used in separate experiments. Attempts were made to remove or inactivate these virus contaminants by laundering the woolskins in a quaternary ammonium disinfectant, a phenolic disinfectant, or alkalinized glutaraldehyde, in combination with an anionic detergent or a nonionic detergent. The effect of a commercial detergent-sanitizer was also studied. The virus titers were significantly reduced in all experiments, but only laundering in glutaraldehyde in combination with either detergent lowered the vaccinia virus titers to below detectable limits. High concentrations of glutaraldehyde altered the texture of the wool and leather apparently by precipitating a component of the detergent onto the fibers. In all the poliovirus experiments, the virus was still detectable on either or both the wool and the leather of the pads after laundering. The rinse water from each experiment was tested for the presence of virus. No vaccinia virus was recovered, but poliovirus was demonstrated in titers up to 10(3) cell culture 50% infectious doses.


Isolation of ether-resistant enteroviruses from sewage: methodology. Experiments were conducted to determine whether polio type 1 (Mahoney and coxsackie A8 viruses adsorb onto cotton fibers of sewer swabs. Negative results were obtained. It has been shown that viruses may exist in sewage as free virus particles or as bound (adsorbed) virus particles. The sewer-swab method of sampling is superior because it filters out the bound virus over several days; when collected, it represents a catch (grab) sample at that particular time which may or may not contain free virus. A simple method for the preparation of sewage inocula for virus isolations is described which samples the bound virus fraction. Only ether-resistant viruses can be isolated, and an ultracentrifuge is not required. By this method, an isolation rate between 60 and 80% of positive sewer swabs can be achieved. Corresponding figures of 84 and 96% were achieved by concentration of sewer-swab eluates with an ultracentrifuge. Quantitative studies showed that the virus concentration in raw sewage can be as high as one infectious particle per 0.5 ml.


Detection of agglutinins in chickens infected with JM leukosis virus. Hemagglutinins for sheep red blood cells were detected in sera from JM virus-infected single-comb White Leghorn (susceptible S line) chickens. The agglutinins were not sedimented at 97,000 x g and were not affected by freezing and thawing, possibly indicating a soluble hemagglutinating factor. Agglutination titers were read in a relatively short period, after 4 hr of incubation at 4 C. The usefulness of this test for quick and low-cost screening of a large number of samples is indicated.


Polymyxin-coagulase-mannitol-agar. I. A selective isolation medium for coagulase-positive Staphylococci. A selective, differential plating medium was developed for the isolation and identification of coagulase-positive and mannitol-fermenting staphylococci. Coagulase produced by growing Staphylococcus aureus caused an opaque zone of fibrin to form around each colony. Several strains of S. aureus produced a visible coagulase reaction by 8 hr, and all strains gave a positive reaction before 12 hr. Mannitol fermentation was usually observed between 12 and 36 hr. Rabbit serum was filtered through Sephadex G-100 to obtain plasmin- and plasminogen-free coagulase-reacting factor (CRF). False-negative reactions, caused by staphylokinase and staphylococcal Müller factor action on plasminogen, were eliminated when this CRF was used. False-positive reactions by lipolytic, coagulase-negative staphylococci were reduced, since gel filtration removed the serum lipoprotein which served as a primary source of opacity. The addition of 75 mug of polymyxin B per ml selectively retarded the growth of S. epidermidis and minimized false-positive reactions caused by citrate-utilizing gram-negative rods. The preparation, characteristics, and use of the medium are presented.


Miniature cell culture systems for use in field isolation of viruses: cell stability and sensitivity to selected laboratory-propagated viruses during storage in miniaturized environments. Cell cultures were miniaturized in 1-dr vials or in capillary tubes (100 by 3 mm) and examined for their capacity to maintain normal gross morphology and sensitivity to infection by viruses during storage under a variety of conditions. The purpose of these studies was to determine the feasibility of using such cultures in the field during epidemiological investigations. From the results of this work it was concluded that such a feasibility exists.


Inactivation of vesicular stomatitis virus by disinfectants. Twenty-four chemical disinfectants considered to be viricidal were tested. Ten disinfectants were not viricidal for vesicular stomatitis virus within 10 min at 20 C when an LD(50) titer of 10(8.5) virus units per 0.1 ml were to be inactivated. Quantitative inactivation experiments were done with acid, alkaline, and a substituted phenolic disinfectant to determine the kinetics of the virus inactivation. Substituted phenolic disinfectants, halogens, and cresylic and hydrochloric acids were viricidal. Basic compounds such as lye and sodium metasilicate were not viricidal.


Test method for determining the viricidal activity of disinfectants against vesicular stomatitis virus. A test method using embryonating chicken eggs for the evaluation of several types of disinfectants as viricides against vesicular stomatitis virus was developed which gave specific, reproducible results.


Susceptibility of genital mycoplasmas to antimicrobial agents. The susceptibility of 11 T-strains, 12 strains of Mycoplasma hominis, and a single strain of M. fermentans to 15 antimicrobial agents was determined by study of inhibition of metabolic activity in a broth dilution system. All three species were inhibited by tetracycline, chloramphenicol, streptomycin, gentamicin, and kanamycin, and were relatively resistant to cephalothin, cephaloridine, polymyxin, vancomycin, and ampicillin. Three antimicrobial agents had significant differential effects on these species. Erythromycin was more active against T-strains than against M. hominis or M. fermentans. Lincomycin, clindamycin, and nitrofurantoin had greater activity against M. hominis and M. fermentans than against T-strains. The activity of the drugs tested was generally uniform over a wide range of inocula. The effect of pH and the difference between minimal inhibiting and minimal mycoplasmacidal concentrations of the drugs tested were consistent with expectations based on the effects of these drugs on bacteria.


A discussion of the neurophysiological basis of disturbances in consciousness: a case report in the pons tumor.


Percent cesium-134 and strontium-85 in milk, urine, and feces of goats on normal and verxite-containing diets.


Verxite flakes for in vivo binding of cesium-134 in cows.


Nutritional requirements of rat ascites hepatoma cells of strain JTC-16 (AH-7974) in tissue culture.


Continuation of studies on the incidence and distribution of different types of foot-and-mouth disease virus in India.


The virulence to rats of five Entamoeba histolytica-like strains capable of growth at 25 degrees C and attempts to discover simular strains.


Isolation and partial characterization of a major inositol-containing lipid in baker's yeast, mannosyl-diinositol, diphosphoryl-ceramide. A polar lipid containing about 20 per cent of the lipid soluble inositol has been purified from cells of Saccharomyces cerevisiae. This compound labeled with (3)H-inositol, (32)P(i), or (14)C glucose was isolated from aqueous pyridine extracts by means of paper chromatography. Unlabeled compound was obtained by a differential solubility scheme. Analytical and degradation studies suggest that this compound can be formulated as a mannosyl-diinositol, diphosphoryl-ceramide. It can be converted by treatment with base or acid into a mannosylmonoinositol phosphoryl-ceramide, a composition which relates it to the basic structure of the phytoglycolipids.


Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells. Two- to fourfold increases in uridine and phosphate uptake were brought about within 10 to 15 minutes after adding fresh serum to confluent 3T3 cells. The stimulation of transport was specific, since no serum effect was observed for 3-O-methyl-D-glucose or amino acids. The early increase in RNA labeling, previously identified by (14)C-uridine incorporation, could be accounted for by this transport effect. Increased labeling with (32)P-phosphate of at least five phospholipids occurred soon after adding serum. This increase, however, could not be accounted for by increased transport. Both of these results suggest that specific early membrane changes are involved in "contact inhibition."The following results are consistent with this suggestion. Uptake of uridine and phosphate by nonconfluent 3T3 cells was higher than by confluent cells and was only slightly increased by fresh serum. In contrast, uptake of these substrates by Polyoma virus-transformed 3T3 cells, which are not subject to "contact inhibition," was not significantly decreased after the cells became confluent, and serum addition had no effect on transport by either nonconfluent or confluent Polyoma virus-transformed 3T3 cells. Fractionation of serum on Sephadex G-200 demonstrated that the factor which stimulated phosphate transport was different from the previously identified factor which stimulates DNA synthesis by confluent 3T3 cells.


Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids). Two-stranded polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids protect against herpes simplex virus-induced cytopathogenicity in HEp 2 cultures, systemic herpes simplex virus infection in mice, and herpes simplex virus-induced keratoconjunctivitis in rabbits.


Hybridization of RNA from Rous sarcoma virus with cellular and viral DNA's. The RNA of Rous sarcoma virus (RSV) hybridizes with DNA's isolated from all eukaryotes tested (animal and plant) with the possible exception of yeast. Bacterial DNA's show no homology to RSV-RNA. DNA's from the oncogenic viruses, adenovirus type 12 and SV40 show significant homology with RSV-RNA, but those from nononcogenic adenoviruses types 2 and 4 are not homologous.RSV-RNA hybridized to all of the DNA's examined has the same, or a closely similar, base composition. Moreover, the melting temperatures of all of the hybrids analyzed are very similar, further suggesting that a common base sequence in DNA functions in hybridization with RSV-RNA.


On the role of DNA synthesis in avian tumor virus infection. Preinfection of chick embryo fibroblasts with an avian tumor virus does not eliminate the requirement of early DNA synthesis for other avian tumor viruses superinfecting the same cells several days after the primary inoculum. The function served by the early DNA in avian tumor virus infection either fails to persist into late infection or is genetically specific for each viral type.


Activation of rabbit liver fructose diphosphatase by coenzyme A and acyl carrier protein. The catalytic activity of rabbit liver fructose diphosphatase is enhanced more than fourfold by treatment with coenzyme A or acyl carrier protein. Other sulfhydryl compounds, such as glutathione or cysteine, are without effect. Activation is reversed by reduced glutathione or cysteine, indicating that the enzyme and activator are linked by disulfide bridges. The activated enzyme derivative can be formed by a disulfide exchange reaction at alkaline pH or by an oxidation reaction which proceeds at neutral pH. The latter process requires O(2) and Cu(++), and is inhibited by EDTA.


Marek's disease herpes virus: a cytomegalovirus. The DNA of herpes viruses associated with Marek's disease of fowl contains 56-57 moles of guanine and cytosine per 100. The composition of its DNA and lack of infectiousness of cell-free preparations suggest that the herpes virus associated with Marek's disease belongs to the herpes virus group B which contains predominantly cytomegaloviruses.


A stimulation by cyclic 3',5'-adenosine monophosphate of amino acid activation and polymerization in reticulocyte hemolysates. With reticulocyte supernatant, cyclic 3',5'-adenosine monophosphate at concentrations of 10(-3) to 10(-2)M causes stimulation of aminoacyl-tRNA synthetases for some, e.g., valine and leucine, but not all, amino acids; it is highest at nonsaturating concentrations of ATP. Similar concentrations of cyclic 3',5'-adenosine monophosphate are found to stimulate phenylalanine polymerization from phenylalanyl transfer ribonucleic acid on polyuridylic acid-charged reticulocyte ribosomes. The degree of stimulation is highest at low GTP concentrations. It is abolished by addition of phosphoenolpyruvate + pyruvate kinase, which stimulate similarly or more effectively at low GTP levels. Under the conditions of these experiments, cyclic 3',5'-adenosine monophosphate did not appreciably inhibit GTP hydrolysis.


Pathology of ectopic ACTH syndrome with emphasis on pituitary Crooke cells and adrenocortical hyperplasia related to ACTH activities in tumor tissues.


Cytochemical and ultrastructural studies of chromatolysis in neurones infected with Herpes simplex virus.


The adrenergic innervation in the esophagus and respiratory tract of the rabbit.


A trial to obtain in vitro a metronidazol-resistant strain of Entamoeba histolytica.


Janus green B and experimental syndactyly in chick embryos.


Dopa-decarboxylase and monoamine oxidase activities in a transplantable islet cell tumor of the golden hamster.


Experimental model systems of pneumoconiosis. I. The effect of dusts on subcutaneous sponge implants in the rat.


Experimental model systems of pneumoconiosis. II. The effect of direct and intravenous injection of silica on the rat liver.


Comparison of pituitary-adrenocortical function in asthmatic patients given long-term corticosteroid therapy and in asthmatics who have not received adrenal steroids.


Chronic lactic acidosis in an adult. A new syndrome associated with an altered redox state of certain NAD-NADH coupled reactions.


Abnormal responsiveness of the renin aldosterone system to acute stimulation in patients with essential hypertension.


Overall regulation of the circulation.

Overall regulation of the circulation.


Comparative physiology: chromatophores.

Comparative physiology: chromatophores.


Presence of life-shortening factors in spleens of aged mice of long lifespan and extension of life expectancy by splenectomy.


Sedimentable and non-sedimentable interfering components in mouse embryo cultures treated with molluscum contagiosum virus.


Observations on the structure of the nucleocapsids of some paramyxoviruses.


Patterns of cytopathology and lysosomal enzyme release in poliovirus-infected HEp-2 cells treated with either 2-(alpha-hydroxybenzyl)-benzimidazole or guanidine HCl.


Factors affecting the growth of Rhinovirus 2 in suspension cultures of L132 cells.


Dependence of murine sarcoma virus infection on the cell cycle.


Infection of chick embryo fibroblasts with template active RNA from avian myeloblastosis virus.


Observations on cultures of rabbit retina infected with vaccinia and herpes simplex virus.


Identification of poliovirus temperature-sensitive mutants having defects in virus structural protein.


An ultrastructural histochemical study of brown adipose tissue from neonatal rats.


Immunofluorescent localization of vitamin D-dependent calcium-binding protein.


Extracellular enzymes of Blastomyces dermatitidis.


Effects of monovalent cations on the spontaneous transmitter release in the neuromuscular junction of toad in the presence of ethanol.


Causes of blindness in Sweden.

Causes of blindness in Sweden.


Fluorescein angiography of the vessels of the iris in pseudoexfoliation of the lens capsule, capsular glaucoma and some other forms of glaucoma.


An outbreak of acute respiratory disease in Trinidad associated with para-influenza viruses.


Antigenic variants of coxsackievirus type A24.


Familial systemic paramyloidosis with lattice dystrophy of the cornea, progressive cranial neuropathy, skin changes and various internal symptoms. A previously unrecognized heritable syndrome.


Mode of action of viomycin on Rhizobium meliloti.


An improved method for the preparation of a stable noninfective western equine encephalomyelitis diagnostic antigen.


Method for determining Bacillus thuringiensis var. thuringiensis Berliner in soil.


Metabolism of Clostridium perfringens type A. I. Cultural conditions which provide stable cell suspensions.


Tentative method of analysis for antimony content of the atmosphere. 12102-01-69T.


Herpetic whitlows: results of treatment with idoxuridine.


Eruptive histiocytoma in a dog.

Eruptive histiocytoma in a dog.


Symposium on immunity to selected canine infectious diseases.


The prognosis in zoster paralysis.

The prognosis in zoster paralysis.


Retinal anlage tumor of the epididymis: a case report.


Virilizing adrenal adenoma: report of a case investigated angiographically.


A defect in pyruvate decarboxylase in a child with an intermittent movement disorder. A patient with an intermittent movement disorder has been found to have an inherited defect in pyruvate decarboxylase ((2-oxo-acid carboxy-lyase, E.C. 4.1.1.1.). The patient is a 9 yr old boy who since infancy has had repeated episodes of a combined cerebellar and choreoathetoid movement disorder. He has an elevated level of pyruvic acid in his blood, an elevated urinary alanine content, and less marked elevations in blood alanine and lactate. Methods were developed to study his metabolic abnormality in dilute suspensions of white blood cells and cultured skin fibroblasts, as well as in cell-free sonicates of fibroblasts. Oxidation of pyruvic acid-1-(14)C and pyruvic acid-2-(14)C by his cells and pyruvate decarboxylase activity in sonicates of his cells were less than 20% of those in cells from control subjects. Oxidation of glutamic acid-U-(14)C, acetate-1-(14)C, and palmitate-1-(14)C was normal, as was incorporation of alanine-U-(14)C into protein. The rate of oxidation of pyruvic acid by the father's cells and the activity of pyruvate decarboxylase in the father's sonicated fibroblasts were intermediate between those of the patient and those of controls. Values for the mother were at or just below the lower limits of the ranges in controls. Kinetic data suggested the posibility of several forms of pyruvate decarboxylase in this family. Possible mechanisms relating the chemical abnormality and the clinical symptoms in this patient are discussed.


Estrogen therapy and coronary artery disease: experimental studies in pigeons.


Clinical path conference. Uremia after Wilms's tumor therapy.


Pregnancy tests.

Pregnancy tests.


The Narcotic Addict Rehabilitation Act: a change in the federal response to the treatment of narcotic addiction.


Euplotes eurystomus: histochemical identification of monamine oxidase, phosphomonoesterases, lipase and cytochrome oxidase.


Single and low dosage regimens of metronidazole in amoebic dysentery and amoebic liver abscess.


Perianal Paget's disease.

Perianal Paget's disease.


Nitrogen dioxide inhibition of viral-induced resistance in alveolar monocytes.


Use of nonimmersed in vitro chicken tracheal preparation for the study of ciliary transport activity. Cigarette smoke and related components.


Mucus production and ciliary transport activity. In vivo studies using the chicken.


Mycobacterium leprae in nerve lesions in lepromatous leprosy. An electron microscopic study.


Collagenase inhibitors in prevention of ulcers of alkali-burned cornea.


Repair of the vagus.

Repair of the vagus.


Effects of adenosine compounds on renal function and renin secretion in dogs.


Pathogensis, diagnosis, and treatment of the tarsal-tunnel syndrome.


Comparative sensitivity of two techniques of specimen inoculation for the isolation of viruses.


Respiration of the cochlea and function.


Pigmented villonodular synovitis of joints. Histological and clinical problems in diagnosis.


Supraspinal and segmental control of static and dynamic gamma-motoneurones in the cat.


Electron microscopic and histochemical observations on the supraoptic nucleus of normal and dehydrated rats.


Effect of training on replicability of assessments of skeletal maturity (Greulich-Pyle).


Massive calcification of the brain in a newborn infant.


Respiration-linked ATP formation by an "oxidative phosphorylation mutant" of yeast.


Organization of the membrane-bound penicillinases of Bacillus licheniformis.


Assays of glutamine and its aminotransferase with the enol-borate of phenylpyruvate.


Incorporation of 5-iodo-2'-deoxyuridine-131-I into nuclear and mitochondrial DNA of normal and malignant mouse tissues.


Redox potentials and phosphorylative efficiency of mitochondria.


Equilibration of reducing equivalents among the terminal portions of the mitochondrial respiratory chains.


Studies on an aged preparation of nucleoside diphosphatase. Kinetics and reaction mechanism.


On the rate law and mechanism of the adenosine triphosphate--pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases.


Natural inhibitors of the transfer ribonucleic acid methylases.


Alteration of the conformative response and inhibition of xanthosine 5'-phosphate aminase by adenine glycosides.


Primary and secondary effects of angiotensin on the coronary circulation.


Lung scleroproteins in age and emphysema.


Morphologic findings in human cardiac allografts.


The aged patient with a peripheral neuropathy.


The philosophy of stroke rehabilitation.


Malignant mucocele of the appendix with thromboembolic manifestation.


Electromyographic findings and conduction velocity on N-hexane polyneuropathy.


Gout.

Gout.


Uremia: newer concepts in pathogenesis and treatment.


Nutritional deficiencies in liver disease.


Aldosteronism in hypertensive disease.

Aldosteronism in hypertensive disease.


Hypoglycemia: a complex problem.

Hypoglycemia: a complex problem.


Collagenase: its physiological and pathological role.


Studies in glycogen storage disease. IV. Leukocyte phosphorylase in a family with type VI GSD.


Plasma insulin in disorders of carbohydrate metabolism.


The requirement of capreomycin, ethambutol and rifampicin in chronic pulmonary tuberculosis in Helsinki on the basis of resistance indications.


An electron paramagnetic resonance study of irradiated frozen aqueous sugar solutions. UCLA 12-724.


The onset of effect of ACTH, angiotensin II and raised plasma potassium concentration on the adrenal cortex.


Long term culture of normal and neoplastic human glia.


Primary superficial carcinomas of the duodenum.


Investigations on the enzymes and toxins of staphylococci. Study of phosphatase using p-nitrophenyl phosphate as substrate.


Studies of Echovirus type 6 antigens in immunodiffusion. 2. Immunoelectrophoretic investigation.


Studies of echovirus type 6 antigens in immunodiffusion. 3. Antibody response against echovirus 6 antigens in human infections with homologous and heterologous enteroviruses.


Two cases of primary carcinoma of the liver in children.


Effect of corticotrophin therapy on pituitary-adrenal function.


Studies of herpes zoster virus in vitro. I. Isolation of two variants.


Plaque formation by three variants of the Miyama strain of herpes simplex virus.


A highly branched alpha-D-glucan of Vibrio parahaemolyticus A55. I. Its isolation and structure.


The reduction of fungal laccase at high pH.


A comparative study of palmitoyl-CoA synthetase activity in rat-liver, heart and gut mitochondrial and microsomal preparations.


Further studies on the NADH oxidase of the cytoplasmic membrane of Mycobacterium tuberculosis.


Acetylene reduction with physiological electron donors by extracts and particulate fractions from nitrogen-fixing Azotobacter chroococcum.


Occurrence of both a-type and o-type cytochromes as the functional terminal oxidases in Rhodopseudomonas spheroides.


Light- and chemically-induced oxidation-reduction reactions in chromatophore fractions of Rhodospirillum rubrum.


Chloroplast inorganic pyrophosphatase.

Chloroplast inorganic pyrophosphatase.


Solubilization and properties of the hydrogenase of Chromatium.


The electron transport systems of heart muscle and yeast: site of inhibition by chloramphenicol.


Structural studies on the active center of alpha-glycerolphosphate dehydrogenase.


Purification and properties of Drosophila malate dehydrogenases.


Structure-function studies on glyceraldehyde-3-phosphate dehydrogenase. II. The effects of S-carboxymethylation on enzymatic activity.


The effect of NAD+ on the catalytic efficiency of glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle.


Purification of aminopeptidase A in human serum and degradation of angiotensin II by the purified enzyme.


Aspects of the kinetic properties of lysyl-tRNA synthetase from Escherichia coli, strain B.


Application of a rapid colorimetric assay to detect alterations in rat proline imino peptidase.


Separation of collagenase and peptidase activities of tadpole tissues in culture.


Evidence of a specific copper(II) in human ceruloplasmin as a binding site for inhibitory anions.


Studies with angiotensins I and II; the use of phenylthiocarbamyl-derivatives.


The conversion of [35S] PTC-angiotensin I to PTC-angiotensin II in plasma of normotensive and hypertensive subjects.


Angiotensin blood levels during the evolution of acute renal failure.


Heterokaryon formation between alkaline phosphatase variants in a human heteroploid cell line.


Hypercalcemia and increased parathyroid-hormone activity in a primary hepatoma. Studies before and after hepatic transplantation.


Islet-cell adenoma of the pancreas with reversible watery diarrhea and hypokalemia. WDHA syndrome.


Viruses, Mycoplasma pneumoniae and bacteria associated with lower respiratory tract disease among infants.


Ecologic studies of vesicular stomatitis virus. II. Results of experimental infection in Panamanian wild animals.


Dysimmunoglobulinemia associated with hepatobiliary disorders.


Interrelationships of renin and aldosterone in a patient with hypoaldosteronism.


Studies of arthropod-borne virus infections in chiroptera. VI. Isolation of Japanese B encephalitis virus from naturally infected bats.


Disease patterns and vaccine-response studies in isolated Micronesian populations.


Studies of arthropod-borne virus infections in chiroptera. VII. Serologic evidence of natural Japanese B encephalitis virus infection in bats.


Broadening spectrum of Herpesvirus hominis (Herpes simplex).


A new device for monitoring force of thumb adduction.


A new theory of the action of muscle relaxants.


Fatal Japanese encephalitis virus infection in immunosuppresed spider monkeys.


Scanning and transmission electron microscopic observations of the topographic anatomy of dendritic lesions in the rabbit cornea.


Spin transfer in gamma-irradiated nucleotide complexes.


Endothelial lesions of rabbit cornea produced by herpes simplex virus.


Gas gangrene: the spectre still looms.

Gas gangrene: the spectre still looms.


Chemical and biological properties of the purified O antigen of Bordetella pertussis.


Production of pathogen free avian cell substrate for production of vaccines.


Isolation of a Golgi apparatus-rich fraction from rat liver. II. Enzymatic characterization and comparison with other cell fractions. Enzymatic activities associated with Golgi apparatus-, endoplasmic reticulum-, plasma membrane-, mitochondria-, and microbody-rich cell fractions isolated from rat liver were determined and used as a basis for estimating fraction purity. Succinic dehydrogenase and cytochrome oxidase (mitochondria) activities were low in the Golgi apparatus-rich fraction. On the basis of glucose-6-phosphatase (endoplasmic reticulum) and 5'-nucleotidase (plasma membrane) activities, the Golgi apparatus-rich fraction obtained directly from sucrose gradients was estimated to contain no more than 10% endoplasmic reticulum- and 11% plasma membrane-derived material. Total protein contribution of endoplasmic reticulum, mitochondria, plasma membrane, microbodies (uric acid oxidase), and lysosomes (acid phosphatase) to the Golgi apparatus-rich fraction was estimated to be no more than 20-30% and decreased to less than 10% with further washing. The results show that purified Golgi apparatus fractions isolated routinely may exceed 80% Golgi apparatus-derived material. Nucleoside di- and triphosphatase activities were enriched 2-3-fold in the Golgi apparatus fraction relative to the total homogenate, and of a total of more than 25 enzyme-substrate combinations reported, only thiamine pyrophosphatase showed a significantly greater enrichment.


Management of chemodectomas (glomus jugulare).


Association of a [corrected] murine leukaemia virus from a mouse lymphoma (2731-L) associated [corrected] with reovirus type 3 infection.


Bridging the gap in continuity of care.

Bridging the gap in continuity of care.


Surface leukaemic antigen and malignancy of cells in mice infected with Mazurenko virus.


Pineal gland: dibutyryl cyclic adenosine monophosphate stimulation of labeled melatonin production. In organ cultures of intact rat pineal glands, N(6)O(2')-dibutyryl adenosine 3', 5'-monophosphate stimulates the conversion of tritiated trytophan to tritiated melatonin, as does L-norepinephrine. Potential sites of stimulation of melatonin production by dibutyryl cyclic adenosine monophosphate are discussed, based on observations that the dibutyryl analog also stimulates the conversion of serotonin labeled with carbon-14 to carbon-14-labeled melatonin without altering hydroxyin-dole-O-methyl transferase activity or intracellular accumulation of serotonin labeled with carbon-14.


Paradoxical sleep in two species of avian predator (Falconiformes). Periods of disconjugate. and conjugate eye movements occur during the sleep cycle in Buteo jamaicensis arborealis and Herpetotheres cachinnans chapmanni. Electromyograms are essentially isoelectric throughout sleep. Slow waves appear only in short bursts of low amplitude in contrast to the long trains of high-amplitude waves reported for chickens and pigeons.


Effects of carbon dioxide, bicarbonate and pH on lactate and pyruvate in the brain of rats.


Transplantation antigen program. ORNL-4419.


Antigenic characterization of poliovirus strains  isolated in Italy (1964-1968) from vaccinated and unvaccinated patients.


Continuous monitoring of blood glucose during operation for islet cell adenomas.


Clinical and endocrine side-effects of methylprednisolone acetate as used in hay-fever. Eight patients were treated with two 80-mg. doses of methylprednisolone acetate (Depo-Medrone), given at an interval of two weeks. Pituitary-adrenal function was assessed before, during, and after treatment.Plasma cortisol levels were depressed maximally 72 hours after each injection of methylprednisolone acetate, and then gradually returned to normal. The adrenocortical response to administered corticotrophin was similarly affected; in seven patients normal values were again recorded three weeks after the second injection of methylprednisolone acetate. One patient whose adrenal function had returned to normal still showed some degree of pituitary suppression eight weeks after his second injection. Several side-effects were noted, and clinically the patients fared less well than a larger series studied during the previous year.


Renin and acute renal failure: studies in man. Plasma renin concentration was increased, usually appreciably, in 22 out of 25 patients with acute renal failure, the average value being 226 units/litre (mean for normal subjects 8.2 units/1.). The highest renin values were found in the first 10 days of the disease; lower and sometimes normal values were found subsequently. Unequivocal acute tubular necrosis was present in only two of the eight cases examined post mortem.These findings are compatible with Goormaghtigh's proposal that an excess of renin and angiotensin may act within the kidney to produce acute renal failure.


Presence of particles other than the Australia-SH antigen in a case of chronic active hepatitis with cirrhosis. Examination of serum specimens from a patient with chronic active hepatitis proved negative to the Australia-SH antigen by immunodiffusion and by complement fixation. Because the sera were anticomplementary they were examined with the electron microscope, and virus-like structures similar to members of the coronavirus group were identified. The possible significance of this finding in human serum and its relation to mouse hepatitis virus are discussed.A sample of the serum pool containing the MS-1 agent was found negative when examined by immunodiffusion, complement fixation, and electron microscopy. The possible lack of immunological identity between infectious and serum hepatitis is discussed.


A case of endocrine dysfunction with lung carcinoma.


An analysis of the lipolysis in vitro of obese-hyperglycaemic and diabetic mice.


Antilipolysis as a tool in the study of clinical and experimental diabetes. Lecture for the 1968 Minkowski Award.


The mode of action of antifungal agents: effect of pyrrolnitrin on mitochondrial electron transport.


Isolation and crystallization of acyl phosphatase from rabbit muscle.


Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei.


Evidence for a functional change in the plasma membrane of murine sarcoma virus-infected mouse embryo cells. Transport and transport-associated phosphorylation of 14C-2-deoxy-D-glucose.


Azotobacter vinelandii ribonucleic acid polymerase. IX. Alternating copolymer of inosinic and cytidylic residues-directed synthesis of alternating copolymer of guanylic and cytidylic residues.


Adenyl cyclase in fat cells. 3. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones.


Azotobacter vinelandii ribonucleic acid polymerase. X. Some physical properties of the alternating copolymers of inosinic and cytidylic residues and of guanylic and cytidylic acid residues.


Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.


The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver.


The formation of a ternary complex between diphtheria toxin, aminoacyltransferase II, and diphosphopyridine nucleotide.


Electron paramagnetic resonance studies on iron-sulfur proteins of submitochondrial particles from Candida utilis cells.


On the nature of the latency relaxation of frog skeletal muscle.


Collagen resorption in carrageenin granulomas. I. Collagenolytic activity in in vitro explants.


Collagen resorption in carrageenin granulomas. II. Ultrastructure of collagen resorption.


Clostridial organisms in septic abortions. Report of 7 cases.


Malignant mixed müllerian tumors of the uterine corpus.


Arrhenoblastoma in first cousins. Report of 2 cases.


Lactate dehydrogenase isoenzymes and proteins in human gliomas.


Biochemical approach to a tumor localizing agent: 51Cr-beta-glycerophosphate complex.


Synovial sarcoma and its treatment.

Synovial sarcoma and its treatment.


Endolymphatic radiotherapy (ERT) for malignant lymphomas: indications and long-term results.


Reactivatability of soman-inhibited end plate cholinesterase and neuromuscular transmission.


Sendai virus infection of rats as a convenient model of acute respiratory infection.


Exfoliative cytopathology of a primary pulmonary malignant histiocytoma.


Aeromonas and serratia. Comparative study of extracellular deoxyribonuclease production and other biochemical characteristics.


Fibrosarcoma of the chest wall following resection and irradiation of carcinoma of the breast.


Peripheral neuropathy.

Peripheral neuropathy.


Granular cell myoblastoma.

Granular cell myoblastoma.


A melanotic ovarian neoplasm resembling the "retinal anlage" tumor.


Histologic classification of liver-cell carcinoma in infancy and childhood and its clinical evaluation. A study of 70 cases collected in Japan.


The lipid composition of mitochondrial and microsomal fractions of rat myocardial homogenates.


Clear cells of the nipple epidermis.

Clear cells of the nipple epidermis.


Cardiovascular effects of angiotensin mediated by the central nervous system of the rabbit.


Clinical evaluation of complement-fixation-reaction and hemagglutination-inhibition-test in measles of MS patients.


Medical grand rounds at Yale-New Haven Hospital. Diagnosis and management of hypoglycemia.


Myxoviruses and multiple sclerosis.

Myxoviruses and multiple sclerosis.


The role of host-incorporated antigens in the immune response to measles virus.


Chronic viral neuropathies: models for study and food for thought.


Host-specific antigens of lipid-containing RNA-viruses. Viruses as a carrier of cell-specific antigens.


Possible mechanism of adjuvant action.

Possible mechanism of adjuvant action.


Cytologic ultrastructural considerations and studies of the pathogenesis of demyelinating processes.


Clinical problems of acute necrotizing encephalitis.


The comparative study of acute or subacute necrotizing encephalitis in humans to experimental herpes simplex encephalo-myelo-neuritis in newborn to adult mice using fluorescent antibody method.


Ultrastructural studies in progressive multifocal leukoencephalopathy, a demyelinating disease of man of probable viral etiology.


Effects of exogenous adenosine 3',5'-monophosphate in man. 3. Increased response and tolerance to the dibutyryl derivative.


Quantitative determination of phospholipids in small tissue samples.


Ultrastructure of the mammalian adrenal cortex.


Effect of adenosine 5'-triphosphate and nicotinamide adenine dinucleotide on oxidative phosphorylation of aged brain mitochondria.


Transfer of inorganic phosphate across human erythrocyte membranes.


A cookbook of anti-cancer chemotherapy for solid tumors.


The release of H3-norepinephrine in arterial strips studied by the technique of superfusion and transmural stimulation.


Sleep stage characteristics of long and short sleepers. The possibility of different sleep stage characteristics being associated with different sleep lengths was explored by comparing two groups of high school seniors, who characteristically slept 6(1/2) hours or less or who slept 8(1/2) hours or more, with an age-matched control group not selected on the basis of sleep length. All-night electroencephalography was used to examine the sleep stage characteristics of these groups. Compared with the unselected age-matched group, the short sleepers showed no significant diminution in their stage 4 (deep) or rapid eye movement (dream) sleep. The long sleepers were observed to obtain significantly more rapid eye movement sleep than did the other groups.


The intramitochondrial distribution of some enzymes involved in the biosynthesis of rat-liver phospholipids.


Incorporation of 33P in soybean phosphatides.


Lipid composition of isolated rat-thymus nuclei.


On the occurrence of sphinga-4, 8-dienine in oyster glycolipid.


Lipid metabolism in bone and bone cells. I. The in vitro incorporation of [14C] glycerol and [14C] glucose into lipids of bone and bone cell cultures.


The effects of pyridine nucleotides and glycerol on lipid phosphorylation in rat liver mitochondria.


The effect of chain length on the phosphorolysis of oligonucleotides by polynucleotide phosphorylase.


The mechanism of action of sucrose phosphorylase. Isolation and properties of a beta-linked covalent glucose-enzyme complex.


An examination of the zinc requirement for the catalytic activity of 3-phosphoglyceraldehyde dehydrogenase.


Evidence for the biologically active form of cholecalciferol in the intestine.


Stimulation by growth hormone and dexamethasone of labeled cyclic adenosine 3',5'-monophosphate accumulation by white fat cells.


Regulatory characteristics of the diphosphopyridine nucleotide-specific malic enzyme of Escherichia coli.


An essential histidine in the catalytic activities of 3-phosphoglyceraldehyde dehydrogenase.


Kinetic analysis of the phosphorolysis of oligonucleotides by polynucleotide phosphorylase.


Adenyl cyclase in cardiac tissue.

Adenyl cyclase in cardiac tissue.


Particle weight and other biophysical properties of encephalomyocarditis virus.


Ribonucleic acid content of encephalomyocarditis virus.


Target molecular weight of foot-and-mouth disease virus and poliovirus.


Interactions of angiotensin and cocaine on the output of noradrenaline from isolated rabbit hearts.


Synergism between phospholipase A and various peptides and SH-reagents in causing haemolysis.


Cytotropism of leukemia viruses.

Cytotropism of leukemia viruses.


Effects of sodium transport stimulating substances on enzyme activities in the toad bladder.


A respiratory virus study in Great Britain: review and evaluation.


Organ cultures in virology.

Organ cultures in virology.


Plasma metyrapone, adrenocorticotropic hormone, cortisol, and deoxycortisol levels. Sequential changes during oral and intravenous metyrapone administration.


Single-dose metyrapone test.

Single-dose metyrapone test.


Cytomegalovirus infection associated with cardiopulmonary bypass.


Hormonal imbalance and the sarcomata.

Hormonal imbalance and the sarcomata.


Quantitative dissolution of the membrane and preparation of photoreceptor subunits from Rhodopseudomonas spheroides.


Amino acid sequence of cyanogen bromide peptides from the amino-terminal region of chick skicollagen.


Ring-opening reaction of 1-(N,N-dimethylcarbamoyl)pyridinium chloride with hydroxide. A model for the alkaline diphosphopyridine nucleotide reaction.


Structure of the glycopeptide from bovine visual pigment 500.


Nucleotide pool levels in growing, inhibited, and transformed chick fibroblast cells.


Relation of reactivity to structure in pancreatic ribonuclease. I. An analysis of the various reactions with bromoacetate in the pH range 2-7.


Further purification and properties of phosphodiesterase from the carrot.


Relations of reactivity to structure in pancreatic ribonuclease. II. Positions of residues alkylated in certain conditions by bromoacetate.


Quantitation of plasma testosterone by improved competitive protein-binding technique.


Phosphofructokinase and glycolysis in the livers of rats fed a thrombogenic diet.


Potentiation of excitatory junctional potentials and glutamate-induced responses in crayfish muscle by 5'-ribonucleotides.


In vitro action of calcium ions on the interrenal corticosteroidogenesis of the eel (Anguilla anguilla L.).


The inhibitory effect of sodium on the contraction of frog's heart perfused with sucrose solution.


Developments in the field of vitamins.

Developments in the field of vitamins.


Enhancement of haemagglutinin production in polyoma virus-infected Candida by a defined medium and urethan.


Experimental brain tumours in dogs.

Experimental brain tumours in dogs.


The fine structure of equine papillomas and the equine papilloma virus.


Drugs and the mechanism of insulin secretion.


Chemotherapy of chlamydial infections.

Chemotherapy of chlamydial infections.


In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa. Disodium carbenicillin and gentamicin sulfate have both shown promise in the treatment of infections caused by Pseudomonas aeruginosa. This study was designed to explore possible synergistic relationships among the new as well as the established antimicrobial agents used to treat such infections. With an agar dilution technique, minimum inhibitory concentrations of 27 strains of P. aeruginosa were determined in two-dimensional tests. Graphs of equal biological activity (isobolograms) demonstrated moderate synergistic effects of the carbenicillin-gentamicin combination over therapeutically feasible concentration ranges. In contrast, the combination of carbenicillin and polymyxin B showed only additive or slightly antagonistic effects. Tests of bacterial killing confirmed the presence of carbenicillin-gentamicin synergy in 3 of 6 strains of P. aeruginosa, but did not show true antagonism between carbenicillin and polymyxin B. Clinical trials of both drug combinations are advisable to determine whether therapeutic results can be improved, and whether the dosages of gentamicin or polymyxin B can thereby be reduced to lessen their toxic hazards.


Enzymes produced by a Pseudomonas species which inactivate inhibitors of certain viral hemagglutinins. I. Identification and purification of a proteinase and phospholipase C. Filtrates from cultures of a psychrophilic Pseudomonas species, which inactivate serum inhibitors of certain viral hemagglutinins, were shown to contain both lecithinase (phospholipase C) and a proteolytic enzyme with elastase activity. The bacterium was cultivated under conditions favoring production of the respective enzymes, and the enzymes were purified by ammonium sulfate precipitation followed by column chromatography or by gel filtration. The elastase was obtained in crystalline form and was recrystallized. It has properties similar to those of a number of other bacterial elastases but is more heat-labile than most. Although a high degree of purification was achieved for the lecithinase, as evidenced by an increase in specific activity, it was not obtained in crystalline form. Partially purified preparations of the lecithinase had extremely high activity compared to that of commercial preparations of phospholipase C from Clostridium welchii.


Isolation of human enterovirus from mussels. Mussels maintained in sea water heavily polluted with domestic raw sewage have been found to harbor human enteroviruses.


CO as a ligand of photosensitive P-630 transformed from horseradish peroxidase in the presence of indole-3-acetic acid.


Accumulation of oxidized diphosphopyridine nucleotide in mouse liver after administration of reduced diphosphopyridine nucleotide.


Exercise deprivation. Sleep and psychological reactions.


Bactericidal action of selected phenanthroline chelates and related compounds.


Biogenesis of mitochondria. 12. The effects of aminoglycoside antibiotics on the mitochondrial and cytoplasmic protein-synthesizing systems of Saccharomyces cerevisiae.


Wilms' tumor in children. Case histories.


Preparation of a stable noninfective diagnostic antigen for herpes simplex prepared from chick embryo tissue cultures.


The environment and function of invertebrate nerve cells.


Ultrastructural data in cases of necrotizing encephalitis without inclusion bodies.


Verbally induced behavioral responses during sleep.


Different effect of an auditory stimulus as a function of rapid eye movement and non-rapid eye movement sleep.


Effects of sleep state and method of awakening upon thematic apperception test productions at arousal.


Digital computer analysis of the electroencephalogram during rapid eye movement sleep state in man.


Correlates of home dream recall. I. REM sleep in the laboratory as a predictor of home dream recall.


Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-1970.


Herpesvirus infection in burned patients.


Denervation myotonia: a subclinical electromyographic finding.


Leukemia, drugs and ACTH.

Leukemia, drugs and ACTH.


Turban tumors. Endothelioma capitis.

Turban tumors. Endothelioma capitis.


Cushing's disease as a psychosomatic disorder: a selective review of the clinical and experimental literature and a report of ten cases.


Agglutinins in chickens infected with JM leukosis virus.


Further studies of avian osteopetrosis virus. 2. Communication.


Regional ileitis or carcinoma.

Regional ileitis or carcinoma.


The plasma 11-hydroxycorticosteroids responseto insulin-induced hypoglycaemia in children and adolescents.


Histochemical and histo-enzyological investigations of growing cartilage in pseudohypoparathyroidism.


Glucose-6-phosphatase in human endometrium.


Subcellular distributin and arterio-venous differences of synthetic 3H-beta-1-23-corticotrophin-23-amide-acetate in the adrenal of rats.


The pharmacology of ambenoxan (2-(3',6'-dioxaheptyl)-aminomethyl-1:4-benzodioxane), a centrally acting muscle relaxant. 1. The intravenous, subcutaneous and oral toxicity of ambenoxan in mice is reported.2. Ambenoxan is a centrally acting skeletal muscle relaxant shown to be effective in mice, rats, rabbits, dogs and monkeys without loss of the righting reflex.3. It had no peripheral neuromuscular blocking properties.4. Decerebrate rigidity was depressed or abolished in the rabbit.5. The effects of strychnine, leptazol, or tremorine were not antagonized.6. In common with other depressants of the central nervous system, ambenoxan prolonged the sleeping time of hexobarbitone.7. Ambenoxan had no local anaesthetic properties.8. In the anaesthetized cat the drug lowered the blood pressure and reduced the pressor response to adrenaline but not to noradrenaline.


The actions of ethinyloestradiol on the pituitary-adrenal system of the rat.


Relative potencies of some false transmitters on isolated human smooth muscle.


The effects of morphine-like substances and their antagonists on transmission at the neuro-effector junction of the myenteric plexus-longitudinal muscle preparation of the guinea-pig ileum.


Insulin release by isolated pancreatic islets of the mouse incubated in vitro.


The functioning and functional reserve of the adrenal cortex in relation to age.


Malformative syndrome with cryptophthalmia.


The enzyme histochemistry of developing brown fat in the fetal rat.


Experimental copper deficiency in sheep.


Effects of phlorizin on membrane cation-dependent adenosine triphosphatase and p-nitrophenyl phosphatase activities.


Inosinic acid dehydrogenase in mammalian tissues.


Enhancement of brain glutamate dehydrogenase activity and glutamate oxidation by adenine nucleotides.


Fine structure of chromatolytic feline motoneurons.


Isolation of golgi apparatus from rat liver. 3. Lipid and protein composition.


Some recent results in the chemistry and stereochemistry of vitamin D and its isomers.


Glyceraldehydephosphate dehydrogenase from liver. I. Isolation and characterization of the bovine liver enzyme.


Biochemical reactions in essentially nonaqueous systems.


Control of multiplication of uninfected rat cells and rat cells converted by murine sarcoma virus.


Studies on the mechanism of freezing damage to mouse liver using a mitochondrial enzyme assay. II. Comparison of slow and rapid cooling rates.


Factors which preclude growth of bacteria at low temperature.


Nuclear alterations in mammalian cells induced by L-canavanine.


A melanin-dispersing effect of cyclic adenosine monophosphate on Fundulus melanophores.


Polyamide-kieselguhr layer chromatography of antipyretics.


Glucose utilization and hepatic enzyme activities in young gnotobiotic ruminants.


Virulence of respiratory viruses.

Virulence of respiratory viruses.


The immunodepressive effect of a murine plasmodium and its interaction with murine oncogenic viruses.


Isolectric focusing of Clostridium perfringens alpha- and theta- toxins.


Chemodectoma.

Chemodectoma.


Initiation of polyribosome formation in poliovirus-infected HeLa cells.


Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus. I. Isolation and characterization of Ts-a-3T3 cells.


Relationship of bacteria to the etiology of periodontal disease.


Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus. II. Formation of oligometric polyoma DNA molecules.


Interaction of closed circular DNA with intercalative dyes. II. The free energy of superhelix formation in SV40 DNA.


Steroid myopathy complicating McArdle's disease.


The role of skin areas adjacent to extensor muscles in motor neurone excitability: evidence bearing on the physiology of Babinski's response.


Changes in the forearm associated with median nerve compression at the wrist in the guinea-pig.


Remarkable recovery of a steroid-responsive recurrent polyneuropathy.


Experimental canine herpesvirus in the gnotobiotic dog.


Phytochemical investigation of Egyptian Senecio. II. Alkaloids of Senecio aegyptius, S. desfontainei, S. vulgaris, S. petasitis and S. mikanioides.


Free fatty acids in cultured cells.

Free fatty acids in cultured cells.


Cytomegalovirus as a cause of mental retardation.


Sural nerve biopsy.

Sural nerve biopsy.


Comparative effects of temperature exposure on mass and oxidative enzyme activity of brown fat in insectivores, tupaiads and primates.


Cyclic adenosine 3',5'-monophosphate formation in brain slices: stimulation by batrachotoxin, ouabain, veratridine, and potassium ions.


Ouabain-dependent incorporation of 32P from p-nitrophenyl phosphate into a microsomal phosphatase.


Observations on the primary structure of the 23S ribosomal RNA from E. coli.


Some properties of angiotensin converting enzyme in the lung in vivo.


Simultaneous measurement of cytochrome a3 reduction and chemoreceptor afferent activity in the carotid body.


The effect of vitamin D on absorption of calcium and the template activity of chromatin in intestines of rats and chicks.


Correlation between the radioprotective effect of some substances with neurotropic action and inhibition of the respiratory enzymes.


Ultra-structural changes in vestibular sensory end organs after viomycin sulfate intoxication.


Studies of lysosomal alpha-glucosidase. I. Purification and properties of the rat liver enzyme.


Substituent effects on pyridinium ring-opening reactions. Facile ring opening of 1-(N,N-dimethylcarbamoyl)nicotinamide cation.


Metabolism and subcellular location of 25-hydroxycholecalciferol in intestinal mucosa.


An electron paramagnetic resonance study of short-lived free radicals from nucleic acid constituents and related compounds in aqueous solution.


Effect of D (minus)- and L (plus)-threo-chloramphenicol on nucleotide and related respiratory activities in yeast undergoing metabolic repression and de-repression.


Content, synthesis and collectability of amino acids in various structures of the brains of rhesus monkeys.


Inhibitory binocular interaction in the lateral geniculate body of the cat.


Monosynaptic excitation and inhibition of thoracic motoneurons by fibers in the medial longitudinal fasciculus.


The cortical projection onto the paramedian reticular and perihypoglossal nuclei (nucleus praepositus hypoglossi, nucleus intercalatus and nucleus of Roller) of the medulla oblongata of the cat. An experimeal-anatomical study.


Community care--a study of the psychiatric morbidity of a Salvation Army hostel.


The fine structure of the later vestibular nucleus in the rat. II. Synaptic organization.


Cobaloximes(II) and vitamin B12r as oxygen carriers. Evidence for monomeric and dimeric peroxides and superoxides.


Analogs of angiotensin II. II. Mechanism of receptor interaction.


Influence of endogenous and exogenous cyclic 3',5'-AMP on contractile responses induced by oxytocin and calcium in isolated rat uterus.


Effect of glucose on lipolysis and energy metabolism in fat cells.


Analogs of angiotensin II. I. Solid phase synthesis.


Retroperitoneal seminomas without evidence of primary growth.


Steroid hormones: effects on adenyl cyclase activity and adenosine 3',5'-momophosphate in target tissues. The adenyl cyclases of chick oviduct and rat prostate were not stimulated by estrogen and testosterone, respectively, suggesting that growth and differentiation of these target tissues are not mediated by adenosine 3',5'-monophosphate. Estrogen acutely activated adenyl cyclase in the castrate rat uterus, but this was prevented by administration of DL-propranolol, suggesting that the effect was mediated by catecholamines. Progesterone produced a delayed stimulation of oviduct adenyl cyclase preceding and concomitant with the induction of synthesis of avidin.


Encapsidation of free host DNA by simian virus 40: a simian virus 40 pseudovirus. Under specified growth conditions, simian virus 40 encapsidated host DNA in a noncircular form free of viral DNA. Two bands of virus particles were present in cesium chloride equilibrium density centrifugation. The host DNA species contained in the upper band was of a lower molecular weight than the DNA present in the mature virus in the lower band.


Cyclic adenosine monophosphate: andromimetic action on seminal vesicular enzymes. Administration of adenosine 3',5'-monophosphate with theophylline produced testosterone-like induction of hexokinase, phosphofructokinase, pyruvate kinase, and glucose-6-phosphate dehydrogenase in the seminal vesicles of both orchidectomized and immature rats. The N(6)-O(2)'-dibutyryl analog of this cyclic nucleotide produced greater increases in vesicular enzyme activities than those induced by the parent compound. The observed enhancement of the key glycolytic enzymes and of hexose monophosphate shunt dehydrogenase was significantly inhibited by actinomycin D and cycloheximide. The evidence indicates that cyclic adenosine monophosphate may be involved as an intermediary in the action of androgenic hormones on male accessory sex organs.


Evolution of the juxtaglomerular apparatus in the vertebrate kidneys.


The physiologic regulation of erythrocyte metabolism.


Studies on the relationship of viruses to the origin of human breast cancer. II. Viruslike particles in human breast tumors.


On the pressor effect of angiotensin and renin before and after nephrectomy in dogs.


Indoleamines and the central nervous system; a sounding of their clinical significance.


A specific binding site for 3',5' cyclic AMP in rat parotid microsomes.


The influence of hormones on melanogenesis.


Rat hepatoma DNA polymerase: partial analysis of the in vitro DNA product.


Resolution of the methionine synthetase system from Escherichia coli K-12.


Solubilization of myocardial adenyl cyclase.


Four quinone reduction sites in the NADH dehydrogenase complex.


Characterization of respiration-deficient mutant of Saccharomyces cerevisiae lacking cytochromes a and c.


Ultraviolet spectral differences between phosphorylase a and b.


Suppression of a pleiotropic mutant affecting glycerol dissimilation.


4-Thiouridine-specific spin-labeling of E. coli transfer RNA.


Steroid biosynthesis by cultures of normal human adrenal tissue.


Ion-induced water-proton chemical shifts and the conformational stability of macromolecules.


A re-examination of the molecular weight of poliovirus RNA.


Inhibition of mitochondrial respiration by hydroxylamine and its relation to energy conservation.


Periplasmic nucleoside diphosphate sugar hydrolase from Bacillus subtilis.


Reduction of fatty acids to alcohols by cell-free preparations of Euglena gracilis.


Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits.


The influence of alloxan-diabetes and fasting on glycolytic and gluconeogenic enzyme activities of rat intestinal mucosa and liver.


The effect of Ca2+ on the adenyl cyclase of calf brain.


Mechanism of phosphorylation of phosphoprotein during oogenesis in trout in vivo.


Dissociation of lipolysis and protein anabolism by ACTH, bovine growth hormone, and thyroid stimulating hormone in adipose tissue with dibutyryl cyclic AMP and theophylline.


Uptake and metabolism of nicotinic acid by human blood platelets. Effects of structure analogs and metabolic inhibitors.


Tarsal tunnel syndrome. A case report.

Tarsal tunnel syndrome. A case report.


Entrapment of the posterior tibial nerve. A case report.


A survey of genetic resistance to leukosis-sarcoma viruses in commercial stocks of chickens.


Transient myasthenia of the newborn. Clinical and electromyographic studies.


Cooperative study in the evaluation of therapy in multiple sclerosis: ACTH vs placebo in acute exacerbation.


Biochemical characteristics of experimental cerebral infarction: Evidence against lysosomal participation in early cell injury.


Sensory levels associated with painful lesions affecting the spinal roots in man.


Chronic oral ulceration.

Chronic oral ulceration.


Further studies on the pathogenic mechanisms of multiple sclerosis with a proposal for a therapeutic approach.


The excitation pattern of fusimotor and alpha-motor fibers after cerebellar ablation.


Hypoventilation syndrome and obesity: A polygraphic study.


Electrically stimulated release of norepinephrine-H3 and serotonin-H3 from mammalian brain slices: a model for studying the effects of drugs on putative central neurotransmitters.


Studies of the ocular countertoriion reflex.


Behavioral correlates of blood flow and myoglobin concentration in skeletal muscle in cat.


The peripheral neuropathy of globoid cell leukodystrophy.


L-dopa reversal of muscular spasm, vomiting and insomnia in a patient with an atypical form of familial dystonia.


Adenovirus type 8 keratoconjunctivitis in the United States. 3. Epidemiologic, clinical, and microbiologic features.


Silica gel cataract extraction.

Silica gel cataract extraction.


Determination of lead chelated with ethylenediaminetetra-acetic acid in blood after precipitation of protein with perchloric acid.


Retrograde jugular venography.

Retrograde jugular venography.


Infection of dogs and cats with a canine parainfluenza virus and the application of a conglutinating-complement-absorption test on cat serums.


Syndactylism in a neonatal lamb.

Syndactylism in a neonatal lamb.


Demonstration of virus particles in human genital warts.


Relationship of infectious bovine keratoconjunctivitis virus to the virus of infectious bovine rhinotracheitis.


Conditions in vitro which affect respiratory control and capacity for respiration-linked phosphorylation in brown adipose tissue mitochondria.


The properties of mitochondria enriched in vitro with cholesterol.


The nucleotide sequence of methionine transfer RNA-M.


Desensitization of yeast phosphofructokinase to ATP-inhibition by a protein fraction from yeast.


Flavin radical chelates as studies by electron spin resonance and isotopic substitution.


Two cases of Paget's disease of the nipple.


Relation of dopa and 5-HTP to convulsions induced by strychnine and leptazol.


Luteal and endometrial phosphatase activities during the porcine estrous cycle.


A study of viral etiology of aseptic meningitis and encephalitis in Cairo.


Adenoma of the nipple.

Adenoma of the nipple.


Quantitative methods for the concentration of visuses in wastewater.


New antigens in hamster embryo cells transformed in vitro by bovine papilloma extracts.


ESR triplet spectra of acridine dyes.

ESR triplet spectra of acridine dyes.


Effects of alpha methyl tyrosine and p-chlorophenylalanine on the regulation of ACTH secretion.


ESR spectra of some irradiated donor-acceptor systems.


Effect of hypothalamic stimulation on blood glucose in the rabbit.


The development of ideas about the mode of action of insulin.


Selective in vitro antiviral effect on myxovirus strains of guanidine derivatives.


Heart glycosides in poliovirus host cell interaction. I. Effect of digoxin and digitoxin and their aglucons on one step growth curves.


Some properties of alkaline phosphatase in Bacillus species.


Heart glycosides in poliovirus host cell interaction. II. Effect of the time of addition on stimulatory or inhibitory action.


Quantitative determinations by ion-pair extraction. 5. Determination of anions by extraction as ion pairs with a fluorescent cation.


Hypophosphatasia: case reports.

Hypophosphatasia: case reports.


Excitation of photoreceptors. A review.

Excitation of photoreceptors. A review.


Epidemiologic and field observations on avian influenza in Minnesota turkeys.


Serology and gross lesions of turkeys inoculated with an avian influenza A virus, a paramyxovirus, and Mycoplasma gallisepticum.


Avian influenza virus infections. I. Characteristics of influenza A-turkey-Wisconsin-1966 virus.


Preincubation treatment of chicken hatching eggs infected with Salmonella pullorum.