Effects of protein deficiency on certain adaptive responses to exercise.


Effect of polynucleotides on aminoacyl transfer ribonucleic acid synthetases. 3. Inhibition of glutamyl transfer ribonucleic acid synthetase by natural polynucleotides.


Fluorophenylalanine inhibition of tumors in mice on a phenylalanine-deficient diet.


Triphosphoinositide phosphomonoesterase in rat kidney cortex. II. Purification and characterization.


Some observations on the physicochemical properties of hemoglobin M-Hyde Park.


Isolation and properties of mitochondrial RNA from yeast.


Evidence for a substrate-mediated change in conformation of rabbit muscle aldolase.


Reconstitution of the repeating unit of the mitochondrial inner membrane.


The survival of smallpox virus (variola minor) in natural circumstances.


Electron paramagnetic resonance spectroscy. Free radical signals associated with ozonization of linoleic acid.


Corticotrophin preparations.

Corticotrophin preparations.


Use of newborn and infant animals in carcinogenicity testing.


Use of and limitations to the indirect hemagglutination test in the diagnosis of intestinal amebiasis.


The quartz-iodine lamp for color and black-and-white photomicrography.


Some compounds active as antirhinovirus in the plaque inhibition test.


Effect of magnesium deficiency on blood and liver transketolase activity and on the recovery of enzyme activity in thiamine-deficient rats receiving thiamine.


Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran.


Gc group distributions in patients with cancer.


Induction of hepatomas by 4-aminobiphenyl and three of its hydroxylated derivatives administered to newborn mice.


Plasma cell leukemia in BALB-c mice inoculated with subcellular material. I. Incidence and morphology.


Multiplication of avian leukosis virus in the reproductive system of the rooster.


Oncolytic potentials of nonhuman viruses for human cancer. II. Effects of five viruses on heterotransplantable human tumors.


Dimethylnitrosamine-induced hepatic cell carcinoma in rainbow trout.


Studies on L cells persistently infected with polyoma virus: relationship between D particle and other virus-like particles.


The H-2 locus and viral leukemogenesis as studied in congenic strains of mice.


Experimental improvements in the use of Silastic cuff for peripheral nerve repair.


Cellular composition during tumor induction in rats by cycad husk.


Nonaqueous titration of theophylline combinations with acetous perchloric acid.


Effect of deuterium oxide on the culturing of Penicillium janczewskii. II. Isolation of fully deuterated griseofulvin.


Epithelial cell malignancies of the parotid gland.


Free radicals as possible contributors to tobacco-smoke carcinogenesis.


Selective removal of components of tobacco smoke by filtration.


Sequence analysis of specific areas of the 16S and 23S ribosomal RNAs.


Regulation of citrate synthase and microbial taxonomy.


Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.


Dexamethasone-suppressible adrenocortical tumor.


Bioelectronics. Intermolecular electron transfer may play a major role in biological regulation, defense, and cancer.


Recovery of micro-quantities of steroids from silica gel following repeated thin-layer chromatography.


Action mechanism of glucose oxidase of Aspergillus niger.


Comparison of Chlorobium thiosulphatophilum cytochrome c-555 with c-type cytochromes derived from algae and nonsulphur purple bacteria.


Effect of phenobarbital on electron transport system, oxidation and reduction of drugs in liver microsomes of rats of different age.


Characterization of the body weight-decreasing toxicities in mice by the lymphocytosis-promoting factor and the heat-labile toxin of B. pertussis and endotoxin.


Attempts at analysis of toxicity of pertussis vaccine. I. Body weight-decreasing toxicity in mice.


An assay method for corticotropin-releasing activity by intrapituitary microinjection in the rat.


Encephalitis in the newborn pup due to a canine herpesvirus.


Spontaeous bluetongue in Texas white-tailed deer.


Effect of hypophysectomy on the adrenal 17-hydroxycorticosteroid secretion in response to eserine in dogs.


Effect of epsilon amino caproic acid on adrenergic nerve function and tissue monoamine levels.


Bovine herpes mammillitis virus. 3. Observations on experimental infection.


Peripheral nerve compression syndromes in the lower limb.


Studies on the histochemistry of phosphatase enzymes in the juxtaglomerular complex.


Hydrolysis of riboflavin 5'-phosphate by phosphatases of rat kidney.


Further study of the relationship between pre- and postsynaptic potentials in the squid giant synapse. The minimal presynaptic depolarization (MPD) for producing a detectable postsynaptic potential (PSP) was lower than 25 mv in normal or tetrodotoxin (TTX)-containing seawater. The MPD was about 10 mv when a small amount of tetraethylammonium ions (TEA) was injected into the presynaptic terminal. Application of linearly increasing depolarizing current to the normal presynaptic terminal at times produced a PSP before a presynaptic spike was evoked; the rate of rise of the resulting PSP was much slower than that of a PSP triggered by the normal presynaptic spike. A brief depolarizing pulse that preceded the presynaptic spike in normal seawater or the initial transient presynaptic depolarization in TTX decreased the PSP. It increased the PSP when it was applied during the spike or initial transient depolarization. Hyperpolarizing pulses had the reverse effect. The Off-PSP was also modified by inserting pulses at an initial part of the recovery phase of the strong presynaptic depolarization. These results indicate further that increases in Na(+) and K(+) conductance during presynaptic spike activity are not a requirement for transmitter release; the rate of release of transmitter can be controlled by electrical manipulation of the presynaptic terminal; there is a superficial correspondence between the time courses of presynaptic depolarization and the resulting PSP. Thus presynaptic depolarization appears to be only the first step in the series of events constituting excitation-transmitter release coupling. It may not be a necessary step for the release mechanism.


Development of an attenuated live virus vaccine against sheep pox.


The inhibition of glucose-6-phosphatase by phlorizin and structurally related compounds.


Different oligomycin sensitivities of the Na++K+-activated adenosinetriphosphatase and its partial reactions.


Specific anion binding effects on the reactive sites of hemerythrin.


Antilipolytic acition of valinomycin and nonactin in isolated adipose cells through inhibition of adenyl cyclase.


The effect of heterologous antilymphocytic serum on the oncogenic activity of polyoma virus.


Serum placental lactogen levels in patients with molar pregnancy and trophoblastic tumors.


Thin-layer chromatography of keto acid dinitrophenylhydrazones of biological interest.


A kinetic study of the production of light-induced ESR signals in Rhodospirillum rubrum chromatophores.


The catalytic hydrolysis of phosphate ester bonds by thermal polymers of amino acids.


Nucleotides associated with potato starch grains.


Effect of directly and indirectly acting sympathomimetic amines on adrenergic transmitter granules.


Rate of ubiquinone oxidation in electron transport particles reduced by succinate.


Purification and properties of rabbit muscle fructose 1,6-diphosphatase.


The effect of carnitine, fatty acyl carnitine, and fatty acyl coenzyme A on mitochondrial contraction.


Inhibition of viral hemagglutination by aggregated orosomucoid.


A polarization of fluorescence study of alcohol dehydrogenase and its binary and ternary complexes.


Stoichiometry of uncoupler to respiratory assembly in oxidative phosphorylation.


Fourth national conference on Indian health. I. Respiratory infections.


Effect of maternal and fetal hypophysectomy or adrenalectomy on the fetal extra-adrenal chromaffin tissue of the rat.


Occupational health in agriculture. Animal-borne diseases.


Induction of deciduomata in normal and histamine-depleted rats.


Secretory responses and respiratory enzymes of the rat's submaxillary gland after repeated teeth amputations.


WHO collaborative studies on enterovirus reference antisera: second report. This paper summarizes the results of the second part of co-operative studies undertaken by the WHO International Reference Centre for Enteroviruses and a number of WHO Regional Virus Reference Centres, WHO Virus Collaborating Laboratories and other laboratories in a comprehensive testing programme of enterovirus equine antisera. The studies were designed to appraise the specificity of immune serum prepared in horses against 16 representative prototype enteroviruses (polioviruses 2 and 3, coxsackieviruses A7, B1, B2, B4, B5 and B6 and echoviruses 1, 2, 3, 5, 7, 9, 12 and 17). Tests for neutralizing antibody were performed not only against the homologous viruses but also against the homotypic strains available in each laboratory. Tests for heterotypic antibody were made against the entire group of enteroviruses, reoviruses 1-3 and adenoviruses 1-11, 13 and 17. Each serum sample represented a pool of the individual bleedings taken from a group of horses before and after immunization with each virus antigen. The results showed that the homologous geometric mean titres of the immune sera ranged from 7000 to 36 000, whereas the preinoculation sera were negative. Results of the homotypic tests showed the usefulness of the sera. The specificity of the haemagglutination-inhibiting antibody of the sera against coxsackieviruses A7, B1, B5, B6 and echoviruses 3, 7, 12 was demonstrated. The results of the tests performed in tissue culture and mice are discussed. Co-operative testing of other enterovirus equine antisera is now in progress.


Morphological and histochemical studies on the autografts and homografts of the guinea-pig thyroid gland. (3.) Non-specific esterases, acid phosphatase, thiamine pyrophosphatase, and PAS-positive material.


The activity of some hydrolytic enzymes in experimental hypoxia of the brain.


Collagenase activity of gingival tissue affected with periodontal disease.


Renin secretion in the perfused dog kidney.


Activity of 3',5'-AMP phosphodiesterase in liver and adipose tissue of normal and diabetic rats.


Maternal factor in the "hybrid effect" given by a spontaneous mammary carcinoma of C3H mice.


A simple method for the determination of angiotensin I converting enzyme.


The solid phase syntheses of 5-isoleucine-angiotensin I and 5-isoleucine (10-14C(U),-leucine)-angiotensin I.


Levels of enzymes involved in glycolysis, gluconeogenesis, glycogenesis and hexosemonophosphate shunt in rat thyroid.


What do we know about viruses? 4. Cytomegaloviruses.


Studies on cartilage formation. XI. Phosphoglucomutase and glucose-6-phosphatase activities of articular surface in various stages of regeneration.


Effectiveness of N1, N1-anhydrobis (beta-hydroxyethyl) biguanide hydrochloride (ABOB) in the treatment of pharyngoconjunctival fever.


Physics of tissue damage. ORNL-4168.

Physics of tissue damage. ORNL-4168.


Amebic liver abscess.

Amebic liver abscess.


Carcinoma of the esophagus involving the vagus nerves associated with gastric retention simulating pyloric obstruction. A case report.


Azathioprine terapy of ulcerative colitis.


Hydrogen cyanide and phenylthiocarbamide sensitivity, mid-phalangeal hair and color blindness in Yucatán, Mexico.


A comparative study of the antigens of some of the 'histolytica-type" strains of Entamoeba. A qualitative and quantitative evaluation of antigens by indirect hemagglutination, gel-precipitation, and immunoelectrophoresis.


Comparison of intradermal and serologic tests for the diagnosis of amebiasis.


Enzyme studies in the embryonate egg and in tissue culture following inoculation with different viruses.


Studies to determine neutralizing antibody in sera from animals recovered from African swine fever and laboratory animals inoculated with African virus with adjuvants.


Inhibition of antibody production in rats and mice by intravenous injection of interferon-inducing amounts of Sindbis virus or E. coli.


Immune response of steers inoculated with chemically-treated foot-and-mouth disease virus preparations previously studied in swine.


A carrier cell line of measles virus in Lu 106 cells.


Differences between the structures of poliovirus and Sindbis virus infectious ribonucleic acids.


A clinical trial of Glenn type 3 attenuated poliovirus vacine.


Characteristics of a C strain of foot-and-mouth disease virus propagated in BHK 21 cells.


Influence and production of interferon in Rauscher virus infected mice.


Interfering action of myxovirus on polyoma virus in primary mouse embryo cell cultures.


Recovery of cytomegalovirus from the submaxillary glands of ground squirrels.


Host-cell involvement in the expression of the guanidine-dependent phenotype of poliovirus.


The development of antibodies against Sendai virus in childhood.


The influence of cations on the thermal inactivation of vesicular exanthema of swine virus.


Kinetic studies on the formation and destruction of the vasopressor polypeptide, substance A.


Biochemical studies on the teratogenic action of Bidrin and other neuroactive agents in developing hen eggs.


O-isopropylidene derivatives of D-allulose (D-psicose) and D-erythro-hexopyranos-2,3-diulose.


ESR signal of mitochondria, microsome and hepatoma cell.


Comparative studies on phospholipid metabolism in different tissues of guinea pig. II. With special reference to phosphoinositides.


Pathogenesis of sheep pox.

Pathogenesis of sheep pox.


Tumors of the pancreas.

Tumors of the pancreas.


Granulosa cell tumour and fibrosing thecoma (a report of two cases).


Studies on the exophthalmos-producing substance in Bufo regularis.


Histometric and histochemical studies of the hypothalamo-hypophyseal neurosecretory system of spontaneously hypertensive rats and rats with experimental hypertension.


Parathyroid hormone-like action of N6-2'-O-dibutyryladenosine-3'5' (cyclic)-monophosphate on bone explants in tissue culture.


Oncogenesis and poliomyelitis vaccine.

Oncogenesis and poliomyelitis vaccine.


The influence of the foetal adrenals on the development of the spleen of the rabbit foetus.


Acute respiratory illnesses in university (1962-1966), military and industrial (1962-1963) populations.


Biochemical study on the host response to tuberculous infection. IV. Influences of isoniazid, streptomycin, nicotinamide, and cortisone.


Aortopulmonary collateral flow in patients with pulmonary disease.


Hyperprolinaemia in two successive generations of a North American Indian family.


The prognosis of lupus nephritis. Role of clinical-pathologic correlations.


The problem of local recurrence after treatment of soft tissue sarcoma.


Comparative studies with the Zilber (Carr) strain of Rous sarcoma virus (Z-RSV). 3. Suppression of viral replication and focus formation by interferon in vitro.


Potentiation of muscle relaxants by quinidine.


Foot-and-mouth disease in swine. I. The immune response of swine of chemically-treated and non-treated foot-and-mouth disease virus.


Differentiation of reoviruses and picornaviruses by density gradient centrifugation.


The nature of "depolarization block".

The nature of "depolarization block".


The influence of the host cell, ionic strength and chymotrypsin on foot-and-mouth disease virus electrophoretic mobility.


Properties of a new type 3 attenuated poliovirus. VI. Alimentary tract resistance in children fed previously with type 3 Sabin vaccine to reinfection with homologous and heterologous type 3 attenuated poliovirus.


Assessment of long-acting synthetic corticotrophin in hypersensitive asthmatics and normal subjects. The synthetic polypeptide depot-tetracosactrin (Synacthen-Depot) was given to nine steroid-treated asthmatic patients hypersensitive to animal corticotrophin. Eight had a satisfactory increase in plasma and urinary 17-hydroxycorticosteroids (17-OHCS). The remaining patient had been shown previously to have adrenal suppression. None of the patients developed allergic reactions to depot-tetracosactrin, and seven have been receiving regular injections of the polypeptide twice weekly for the past eight months.In 13 normal subjects intramuscular injections of 1 mg. and 0.5 mg. of depot-tetracosactrin and 40 units of corticotrophin-gel were equally potent in raising the plasma 17-OHCS, but depot-tetracosactrin had a significantly longer action than corticotrophin-gel.


The role of game animals in the epizootiology of rinderpest and malignant catarrhal fever in East Africa.


Monosynaptic transmission in the cat's spinal cord. A quantitative measure of anesthetic dose.


Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. 3.


Glomus tumours of the temporal bone.

Glomus tumours of the temporal bone.


Carcinoma of the male breast following radiation. Report of a case occurring 35 years after radiation therapy of unilateral prepubertal gynecomastia.


Conceptual unity of the Müllerian tumor group. A histologic study.


Central mucoepidermoid tumors of the jaws. Review of the literature and case report.


Testicular neoplasms in an infant.

Testicular neoplasms in an infant.


Primary carcinoma of the liver in Mexican adults.


A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production.


The pathology of murine runting and its modification by neomycin sulphate gavages.


Estimation of liver and intestine lipids of rat by silicic acid column chromatography.


Separation of retinol from neutral lipids and phospholipids by silicic acid.


Phytase from Bacillus subtilis.

Phytase from Bacillus subtilis.


Adenovirus infections in Kottayam (Kerala): a preliminary report.


Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor.


Biological timing and the dento-facial complex. 3.


Pulsatile blood flow of gliomas studies with implanted impedance electrodes.


Taste changes in vitamin A deficiency.

Taste changes in vitamin A deficiency. Taste preferences were studied in two groups of rats depleted of vitamin A by dietary restriction. One group received sufficient vitamin A acid supplement to maintain normal growth. The other group was repleted with vitamin A alcohol after the classical deficiency symptoms had appeared; this group gradually lost normal preferences for NaCl and aversion to quinine solutions during depletion. Vitamin A alcohol repletion tended to restore taste preferences to normal. In contrast, the group receiving vitamin A acid showed normal taste preferences throughout the depletion period. When the vitamin A acid supplement was removed taste preferences became abnormal and returned to normal when vitamin A acid was restored. Peripheral gustatory neural activity of depleted rats without any form of vitamin A was less than normal both at rest and when the tongue was stimulated with NaCl solutions. Histological examination showed keratin infiltrating the pores of the taste buds. Accessory glandular tissues were atrophied and debris filled the trenches of the papillae. It is concluded that vitamin A acid can provide the vitamin A required for normal taste, as contrasted with its inability to maintain visual function. It is suggested that the effect of vitamin A is exerted at the receptor level, as a result of its role in the biosynthesis of mucopolysaccharides, which have been recently identified in the pore area of taste buds, as well as being present in the various secretions of the oral cavity.


Dangers of oxidized cellulose in chiasmal surgery. Report of two cases.


Glucose-6-phosphatase activity of mouse pancreatic islets.


Glyceraldehyde 3-phosphate dehydrogenase from pig muscle.


Proposed mode of action of histamine.

Proposed mode of action of histamine.


Engrams in the human brain. Mechanisms of memory.


Nucleic acid molecules: new microdiffusion technique for visualization. A microdiffusion technique, developed for visualization of nucleic acid molecules in the electron microscope, requires less than 0.01 microgram of nucleic acid. Although originally developed for free nucleic acids, the method can be applied to virion suspensions for direct visualization of their genomes; less than 10(10) virions per milliliter are required. Results agree well with those yielded by the diffusion technique of Lang, Kleinschmidt, and Zahn.


Herpesvirus type 2: association with carcinoma of the cervix. By utilizing the kinetics of neutralization, it was found that an antibody response to type 1 (oral) and type 2 (genital) herpesvirus infection could be independently measured and correlated with type of virus isolated from the patient. The presence of antibodies to type 1 and type 2 herpesvirus was examined in patients with carcinoma of the cervix, in matched controls, random controls, and patients with other types of malignancy. Antibodies to type 2 were found with greater frequency in patients with carcinoma of the cervix (83 percent) than in the other groups tested (0 to 20 percent). The data suggest an association of genital herpesvirus and carcinoma of the cervix.


Excited electronic states of DNA.

Excited electronic states of DNA.


Induction of collagenolytic and proteolytic activities in rat and human fibroblasts by anti-inflammatory drugs. Confluent monolayers of either mouse or diploid human fibroblasts contained no measurable amounts of either collagenolytic (pH 5.5) or proteolytic (pH 7.5) activities. Within a few hours after exposure of these cells to antiinflammatory drugs, significant amounts of these enzymatic activities were demonstrable extracellularly. These activities were profoundly decreased in cultures simultaneously treated with the anti-inflammatory drugs and cycloheximide or actinomycin D.


Studies on the histochemical distribution of oxidative enzymes in olfactory bulb of rat.


Clinical virology and viral surveillance in a pediatric group practice: the use of double-seeded tissue culture tubes for primary virus isolation.


Respiratory syncytial virus associated with acute respiratory infections in Trinidadian patients.


A comparative study on the localization of certain enzyme activities in the testes of the Indian desert gerbil and the house shrew.


A subclinical outbreak of human rhinovirus 31 infection in chimpanzees.


Bovine papular stomatitis: experimental transmission from man.


The resolution of some steps of the reactions of lactate dehydrogenase with its substrates. 1. The reaction of pig heart lactate dehydrogenase (EC 1.1.1.27) with NAD(+) and lactate to form pyruvate and NADH was followed by rapid spectrophotometric methods. The distinct spectrum of enzyme-bound NADH permits the measurement of the rate of dissociation of this compound. 2. The reduction of the first mole equivalent of NAD(+) per mole of enzyme sites can also be observed, and is much more rapid than the steady-state rate of NADH production. 3. At pH8 the dissociation of the enzyme-NADH complex is rate-determining for the steady-state oxidation of lactate. At lower pH some other step after the interconversion of the ternary complex and before the dissociation of NADH is rate-determining. Other evidence for a compulsory-order mechanism is provided.


Studies on the biosynthesis of nicotinamide adenine dinucleotide (NAD) in mammals and its regulatory mechanism. I.


A spectrophotometric method for the microdetermination of periodate. 1. A method is described for measuring the concentration of periodate over the range 0.2-20mum by adding 1,2-di-(p-dimethylaminophenyl)ethane-1,2-diol to a sample solution. Periodate cleaves this compound to from two molecules of p-dimethylaminobenzaldehyde, the extinction of which is then read at 352mmu. 2. The method has been used to follow the course of periodate oxidations of serine methyl ester, ribonuclease A and ribonuclease S-protein. Addition of the reagent stops further periodate reaction by reducing the remaining periodate to iodate. 3. The presence of protein does not interfere with the assay.


Plaque morphology of Teschen disease viruses and certain pig enteroviruses in primary pig kidney monolayer cultures. Plaque patterns and diameters of four virulent strains and one tissue culture mutant of Teschen disease virus were compared with six pig enteroviruses isolated in the United States. They are described as they were produced in primary pig kidney monolayer cultures. Reproducible plaques, with similar characteristics and class-types of each of the viruses tested were obtained with the application of a 45-minute virus adsorption time. Their morphologic characteristics and the proportion in which the plaque types appeared may assist in the differentiation of these virus strains.


Detection of infectious bovine rhinotracheitis (IBR) by immunofluorescence. Infectious bovine rhinotracheitis can be readily and accurately diagnosed by direct fluorescent antibody techniques on infected bovine embryo kidney monolayers. Non-specific fluorescence was encountered in direct observation of bovine nasal secretions and cotyledon impressions.


Streptozotocin: depression of mouse liver pyridine nucleotides.


The investigation of some antigens of Zajdela ascitic rat hepatoma cells.


Glycolysis in chick embryo cell cultures transformed by Rous sarcoma virus.


Chronotropic and pressor responses to angiotensin in rats anaesthetised with urethane.


Effects of curare-like agents on the block of tetanic contractions produced by neostigmine in the rat.


An action of 5-hydroxytryptamine on the frog motor end-plate.


Evaluation of a family care program for released mental patients.


Effects of viomycin and polymyxin B on protein synthesis in vitro.


Structure and base sequence in the cohesive ends of bacteriophage lambda DNA.


Effect of the chelating agents, EDTA, 2,2'-bipyridine, 8-hydroxyquinoline and pyrophosphoric acid, on norepinephrine uptake by rabbit aorta.


Relaxant effect of cyclic adenosine 3',5'-monophosphate on the isolated rabbit ileum.


Herpesvirus hominis infection at a smallpox vaccination site.


Experimental herpes virus infection in young puppies.


A morphological and histochemical study of the subcommissural organ of young and old sheep.


Cyclic AMP.

Cyclic AMP.


Histidinemia and atopic dermatitis.

Histidinemia and atopic dermatitis.


Pemphigus foliaceus or erythema multiforme.


Tinea rubrum. 1. Tinea pedis and cruris. 2. Verrucous dermatitis perianal. Extramammary Paget's disease.


Biochemical and clinical studies in familial goitre caused by an iodotyrosine deiodinase defect.


Leprosy.

Leprosy.


A planned approach to the surgical patient with iatrogenic adenocortical insufficiency.


Changes in thyroid secretion produced by inhibition of iodotyrosine deiodinase.


Relation of the mass of heterotopic pituitary tissue to its ability to secrete ACTH and TSH in response to amino-glutethimide.


Hypocalcemic effect of imidazole in rats.


Alteration of adrenocortical steroidogenesis in the rat by inhibition of cholesterol biosynthesis.


Hemorrhagic cystitis: adenovirus type 11.


A comparison of the effects of x-radiation on the relative rates of incorporation of labelled thymidine and cytidine into mitochondrial and nuclear DNA of Morris hepatomas.


Pathway for oxidative dissimilation of glycerol in Bacillur subtilis.


Enzymes of glucose formation and turnover in x-irradiated rats.


The effect of fasting on glucose utilization in the isolated perfused rat liver.


Tumors of the scapula. A review of the literature and an analysis of 31 cases.


Functional morphology of the pars intermedia of the rat hypophysis as revealed with the electron microscope. 3. Effects of dexamethasone on the pars intermedia of rats under various experimental conditions.


In vitro and in vivo evaluation of enduracidin, a new peptide antibiotic substance.


Antiviral activity of trichothecin.

Antiviral activity of trichothecin.


Antiviral activity of brefeldin A and verrucarin A.


Serum turbidity responses of anti-inflammatory drugs in endocrine-deficient rats.


Regulation of pyridine nucleotide coenzymes.


The biosynthesis of NAD in the liver of irradiated mice.


Polymerization of ADPR moiety of NAD by nuclear enzyme preparation.


Suppression of growth of herpes simplex virus in chick embryo fibroblasts at 40 degrees C.


Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases.


Treatment of concer in childhood.

Treatment of concer in childhood.


Site of the inhibiting action of diphenylhydantoin on the release of corticotrophin in epileptic patients.


Diencephalic syndrome of emaciation: a case report with special reference to the mechanism of hypothalamic dysfunction.


Studies on phenolic steroids in human subjects. XI. The biosynthesis and proof of structure of estriol-3,16-diglucosiduronate.


Effects of some vertebrate hormones on lipid mobilization in the insect fat body.


Response of the interrenal gland of rainbow trout (Salmo gairdneri) to stress.


Representation of information in neurons and sites for molecular participation.


Histochemical and biochemical studies of the corpuscles of Stannius of the teleost fish Colisa ialia.


Osteosarcomas appearing in Syrian hamsters after treatment with extracts of human osteosarcomas.


Demonstration of cell-bound and humoral immunity against neuroblastoma cells.


The integrated state of viral DNA in SV40-transformed cells.


The neuronal membrane.

The neuronal membrane.


An early alteration in the phospholipid metabolism of lymphocytes by phytohemagglutinin.


Generation of slow postsynaptic potentials without increases in ionic conductance.


Mechanism of DNA chain growth, II. Accumulation of newly synthesized short chains in E. coli infected with ligase-defective T4 phages.


Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.


Physical properties of Rous Sarcoma Virus RNA.


Experimental investigation of shake emulsions of radiopaque oils in the cranial subarachnoid space.


Vascular response to vasopressin as reflected in angiography. An experimental study in the dog.


Community and hospital outbreak of epidemic keratoconjunctivitis.


Wilms' tumor metastatic to the orbit.

Wilms' tumor metastatic to the orbit.


Genetic transmission of mammary tumor inciting viruses in mice; possible implications for murine leukemia.


Collagenolytic activity in bovine corneal epithelium.


The influence of antibodies in vivo and in vitro on cellular and cell-free preparations of atype 3 avian leukosis virus.


Avian leukemia and sarcoma studies.

Avian leukemia and sarcoma studies.


Interactions of RNA oncogenic viruses and cells.


Recent studies on leukemia and solid tumors in mice and man.


Leukosis viruses of chicken structure, antigenic behaviour and cell interactions.


Correlative biological and ultrastructural studies on Rous sarcoma virus in various hosts.


Antibodies in primates to human and simian viruses: a comparative study.


Biochemical studies on cells infectd with RNA-containing tumor viruses.


Role of immunological tolerance in viral leukemogenesis of the mouse.


Recent studies on the etiology of mouse leukemia and lymphomas.


Electron microscopic studies on the organ distribution of GRAFFI leukemia virus in leukemic and preleukemic mice.


Ability of an erythropoietic virus to initiate erythropoiesis in hypertransfused-polycythemic mice.


Multiplicity of cell response to a murine erythroblastosis virus.


Pathology of virus leukemia in the mouse.


Studies on virus attenuation in mouse leukemia.


Biological and physical properties of a leukemogenic agent of a new type of viral murine leukemia.


The effect of nickel chloride on the permeability of the blood-brain barrier.


Development of black down feathering in hybrid chick embryos (cross New Hampshire male with light Sussex female) after pituitary implantation.


Basic aspects of the interaction of oncogenic viruses with heterologous cells.


Surface morphology of frog striated muscle as prepared for and examined in the scanning electron microscope.


Are the excitatory nerves to the circular muscle of the guinea-pig ileum cholinergic?


Factors affecting vascular responses to haemorrhage in the rat.


Noradrenaline as a transmitter in the spinal cord.


Multiplication of infectious canine hepatitis virus in HeLa cells.


The effect of human growth hormone on growth of patients with hypopituitarism. A combined study.


Epinephrine: effect on uptake of iodine by dispersed cells of calf thyroid gland. In isolated thyroid cells I-epinephrine (0.1 and 10.0 micrograms per milliliter), norepinephrine and isoproterenol consistently stimulated the accumulation and organic binding of iodine. The effect was partially inhibited by phentolamine, but not propranolol, and hence may be mediated by alpha receptors. Theophylline did not mimic or enhance the epinephrine effect, suggesting that the latter may not result from activation of adenyl cyclase.


Brain alcohol dehydrogenase.

Brain alcohol dehydrogenase. Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.


Congenital cysts of the liver in infancy and childhood.


Culture isolation and identification of clostridia.


Percutaneous needle aspiration biopsy of the lung.


Centrally mediated orthostatic hypotension. Report of cases.


The physiology of neuromuscular transmission.


Mechanisms of halothane-induced muscle relaxation.


Effects of halothane on neuronal tissue. Neurophysiological aspects.


Biological properties of a transplantable islet-cell tumor of the golden hamster. 3. Electron microscopic studies.


Actions of immobilizing drugs on synaptic transmission.


Neuromuscular syndromes associated with carcinoma.


Septic arthritis of the knee due to Clostridium welchii. Report of two cases.


Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). A new method for demonstrating cytochrome oxidase activity, based upon the oxidative polymerization of 3,3'-diaminobenzidine (DAB) to an osmiophilic reaction product, has improved the localization of this enzyme over methods based upon the Nadi reaction, in both the light and electron microscopes. The reaction product occurs in nondroplet form, which more accurately delineates the localization of cytochrome oxidase in mitochondria of heart, liver, and kidney. In electron microscopic preparations the excess reaction product is found to overflow into the intracristate spaces and into the outer compartment between inner and outer limiting mitochondrial membranes. This finding suggests that the enzymatic activity of cytochrome c is located on the inner surface of the intracristate space which is the outer surface of the inner mitochondrial membrane. Succinic dehydrogenase activity has also been located at this site by using an osmiophilic ditetrazolium salt, TC-NBT. Considered together, the sites of reactivity of both parts of the respiratory chain have implications for the chemiosomotic hypothesis of Mitchell who suggests a mechanism of energy conservation during electron transport in the respiratory chain of the mitochondrion.


Unusual aspects of ultrastructural differentiation in rat hepatoma cells.


Peer group membership of young women with cancer.


A method of recording pulmonary ventilation.


Control of fluid absorption in the renal proximal tubule. Glomerulotubular balance was investigated in isolated, perfused rabbit proximal tubules in vitro in order to evaluate some of the mechanisms proposed to account for the proportionate relationship between glomerular filtration rate and fluid absorption generally observed in vivo. The rate of fluid transport from lumen to bath in proximal convoluted tubules in vitro was approximately equal to the estimated normal rate in vivo. The absorption rate in proximal straight tubules however was approximately one-half as great. If the mechanism responsible for maintenance of glomerulotubular balance is intrinsic to the proximal tubule, as has been proposed on the basis of micropuncture studies, the rate of fluid absorption in vitro should be directly related to the perfusion rate and/or tubule volume. In the present studies absorption rate was only minimally affected when perfusion rate was increased or the tubule distended. Thus, glomerulotubular balance is not mediated by changes in velocity of flow of the tubular fluid or tubular diameter and therefore is not an intrinsic property of the proximal tubule. It has also been proposed that glomerulotubular balance results from a humoral feedback mechanism in which angiotensin directly inhibits fluid absorption by the proximal convoluted tubule. In the present experiments, angiotensin was found to have no significant effect on absorption rate.


The nurses role in intravenous incompatibilities.


Trends and problems in nursing.

Trends and problems in nursing.


D.D.S.: cancer detective.

D.D.S.: cancer detective.


Effect of the route of inoculation on antibody formation in guinea pigs immunized with parinfluenza virus vaccines. The efficiency of the intramuscular route of immunization of guinea pigs was compared with the intraperitoneal route when trivalent parainfluenza virus vaccine was employed as immunogen. When the routes of immunization were compared by effective dose 50, the intramuscular route was more effective. Likewise, a statistical evaluation of conversion rates and of titers revealed significantly higher values for the intramuscular than for the intraperitoneal route to all three components in two of the lots of vaccine tested.


Sensitivity of herpes simplex virus, vaccinia virus, and adenoviruses to deoxyribonucleic acid inhibitors and thiosemicarbazones in a plaque suppression test. Herpes simplex and vaccinia viruses and adenovirus types 1, 2, 5, and 7 were tested by plaque suppression methods for sensitivity to halogenated deoxyuridines (5-iodo-, 5-bromo-, 5-chloro-, and 5-fluoro-), cytosine arabinoside, isatin-beta-thiosemicarbazone, and N-methylisatin-beta-thiosemicarbazone. After incubation for 12 days in HeLa cell cultures, vaccinia virus plaques were still readily suppressed by deoxyribonucleic acid (DNA) inhibitors and thiosemicarbazones. Herpes simplex virus plaques were likewise suppressed by at least three DNA inhibitors. Adenovirus plaques were not suppressed by DNA inhibitors or thiosemicarbazones. 5-Fluoro-2'-deoxyuridine could not be shown to have any antiviral activity, but it did produce a substantial lethal action on the cells.


Detoxification of liquid cultures of Bordetella pertussis by forced aeration at high pH. Cultures of Bordetella pertussis cultivated in shake flasks were invariably highly toxic for mice, but cultures of the same strain grown in vortex-aerated vessels were nontoxic at the time of harvest. Results reported here indicate that toxin is present during the early log phase in vortex-aerated cultures, but is lost as the cultivation proceeds. The loss of toxicity is apparently due to denaturation of the toxin by the combined influence of vigorous aeration and elevated pH.


Clostridium perfringens type A infection of ligated intestinal loops in lambs. Clostridium perfringens type A suspended in fresh medium was injected into ligated intestinal loops of lambs. Within 7 hr after inoculation, the fluid volume of the loops increased up to seven times. No significant accumulation of fluid occurred in loops receiving grown culture, culture supernatant fluid, or medium alone. alpha-Antitoxin injected along with C. perfringens in fresh medium into intestinal loops did not prevent the accumulation of fluid. It is concluded that alpha-toxin plays no major role in C. perfringens type A enteritis.


Enhancement of mengovirus nucleic acid infectivity by putrescine.


Studies on the incorporation of 14-C-sodium acetate into the phospholipids of phytohaemagglutinin-stimulated and unstimulated lymphocytes.


Protein synthesis in nuclei isolated from frozen and thawed mouse liver.


Fusion of cells by HVJ: requirement of concentration of virus particles at the site of contact of two cells for fusion.


Histotypic self-organization by trypsin-dissociated and EDTA-dissociated chick embryo cells.


Biochemistry of shellfish lipids. VII. Occurrence of mannose-6 phosphate in corbicula glycolipid.


The origin of hybrid variants derived from subtype strains of foot-and-mouth disease virus.


Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.


The effect of 5-fluoro-deoxyuridine on the replication of viral DNA and synthesis of polyoma capsid protein.


Influence of animal genotype and age on the amount of circulating interferoh induced by Newcastle disease virus.


The use of batch-type zonal ultracentrifuge rotors for the isolation and purification of viruses.


Rescue of Rous sarcoma virus in mixed cultures of virogenic mammalian and chicken cells, treated and untreated with Sendai virus and detected by focus assay.


Observations on complete and empty capsids of foot-and-mouth disease virus.


Analysis of nearest neighbour base frequencies in the RNA of a mammalian virus: encephalomyocarditis virus.


Incorporation of labelled phosphate into phospholipids in squid giant axons.


Carcinogenic and chronic effects of 4,4'-diaminodiphenylmethane, an epoxyresin hardener.


L-Glutamate at insect excitatory nerve-muscle synapses.


Urinary excretion of steroids by beagle dogs following administration of adrenocorticotrophic hormone. LF-38.


Viruses isolated from Beagle dogs exposed to aerosols of 90Sr and 144Ce. LF-36.


Evidence for divalent metal sequestration by dog kidney microsomes. SAM-TR-67-88.


A method for digital calculation of absolute free radical concentrations. NADC-MR-6804.


Giant retroperitoneal mucocele simulating pseudomyxoma peritonei and mucinous adenocarcinoma.


Studies in viral respiratory infections among Finnish servicemen.


Surgical abnormalities in urachus remnants in adults.


A gastric factor in the pathogenesis of the Zollinger-Ellison syndrome.


Alveolar proteinosis. Its experimental production in rodents.


Identification of the diarrheogenic hormone associated with non-beta islet cell tumors of the pancreas.


Hepatocarcinoma associated with biliary cirrhosis. A case due to congenital bile duct atresia.


Human herpesvirus infection. Its fine structure identification in paraffin-embedded tissue.


Hydroxysteroid dehydrogenase activity in human skin. I. Histochemical techniques for the demonstration of 3-beta-hydroxysteroid dehydrogenase, and a method for the semiquantitation of its activity.


Effects of physostigmine on the afterdischarge and slow postsynaptic potentials of bullfrog sympathetic ganglia. 1. The effects of anticholinesterases (anti-ChEs) (physostigmine, prostigmine and TEPP) on the afterdischarges and the extracellular and intracellular slow potentials of bullfrog sympathetic ganglia were studied.2. The anti-ChEs augmented the early afterdischarge, the late negative potential and the slow excitatory postsynaptic potential. This indicated that the nature of the early afterdischarge was cholinergic (muscarinic) and that the late negative potential or the slow excitatory postsynaptic potential generated the early afterdischarge.3. Since the anti-ChEs increased the positive potential, the depression of the early afterdischarge observed in the presence of an antiChE was explained to be caused by the increased inhibitory effect of the enhanced positive potential.4. Prostigmine and tetraethyl pyrophosphate did not show any appreciable effects on the late afterdischarge, the late late negative potential nor the late slow excitatory postsynaptic potential. This indicated that the nature of the late afterdischarge was non-cholinergic and that the late late negative potential or the late slow excitatory postsynaptic potential generated the late afterdischarge.5. Physostigmine reversibly depressed the late afterdischarge, the late late negative potential and the late slow excitatory postsynaptic potential. The depressant action of physostigmine was not due to its anti-ChE action.


Bioassay of long duration corticotrophin preparations on guinea-pigs.


Enzymatic assay of the prostaglandins.

Enzymatic assay of the prostaglandins.


Presence and properties of dihydrofolate reductases within the genus Trypanosoma.


Cyclic AMP as a mediator of hormonal metabolic effects in brown adipose tissue.


Anti-arrhythmic ancd local anaesthetic activity of some beta-receptor blocking compounds.


Metabolic actions associated with stimulation of alpha- and beta-receptors for adrenaline in smooth muscle.


Electromyography in the diagnosis and treatment of myasthenia gravis.


Adrenergic mechanisms in hypertension.

Adrenergic mechanisms in hypertension.


The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse. 1. Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP). In these animals there was an increase in the glucose content of the supernatants of homogenates of liver and brain following acid hydrolysis.2. Chlorpromazine 40 mg/kg intraperitoneally did not affect Mg(++) activated adenosine triphosphatase (ATPase) activity in the brain.


Changes in the adrenocortical cells of bullfrogs following hormonal stimulation.


Steroid responses to ACTH-like polypeptides.


Limb regeneration in Ambystoma larvae during and after treatment with adult pituitary hormones.


Medullary carcinoma of the thyroid--a cause of Cushing's syndrome: report of two cases.


Differentiation of nerve terminals in the crayfish opener muscle and its functional significance. Junctional potentials (jp's) recorded from superficial distal fibers of the crayfish opener muscle are up to 50 times larger than jp' in superficial central fibers when the single motor axon that innervates the muscle is stimulated at a frequency of 1/sec or less. At 80/sec, in contrast, central jp's are up to four times larger than those observed in distal fibers. The tension produced by single muscle fibers of either type is directly proportional to the integral of the time-voltage curve minus an excitation-contraction coupling threshold of 3 mv. Distal fibers therefore produce almost all the total muscle tension at low frequencies of stimulation and central fibers add an increasingly greater contribution as their nerve endings begin to facilitate in response to increased rate of motor discharge. Differentiation of muscle membrane characteristics (input resistance, space constant, time constant) cannot account for these differences in facilitation ratios. The mechanism of neuronal differentiation is not based upon the size or effectiveness of transmitter quanta, since equal sized jp's have equal variances;: mjp sizes and variances are also equal. No differences were found between fiber types in rates of transmitter mobilization, density of innervation, or the relationship between transmitter release and terminal depolarization. Single terminals on distal fibers were found to release transmitter with a greater probability than central terminals. More effective invasion of distal terminals by the nerve impulse at low frequencies can account for the difference.


Isolated epithelial cells of the toad bladder. Their preparation, oxygen consumption, and electrolyte content. Epithelial cells of the toad bladder were disaggregated with EDTA, trypsin, hyaluronidase, or collagenase and were then scraped free of the underlying connective tissue. In most experiments EDTA was complexed with a divalent cation before the tissue was scraped. Q(OO2), sucrose and inulin spaces, and electrolytes of the isolated cells were measured. Cells disaggregated by collagenase or hyaluronidase consumed O(2) at a rate of 4 microl hr(-1) dry wt(-1). Q(OO2) was increased 50% by ADH (100 U/liter) or by cyclic 3',5'-AMP (10 mM/liter). Na(+)-free Ringer's depressed the Q(OO2) by 40%. The Q(OO2) of cells prepared by trypsin treatment or by two EDTA methods was depressed by Na(+)-free Ringer's but was stimulated relatively little by ADH. Two other EDTA protocols produced cells that did not respond to Na(+) lack or ADH. The intracellular Na(+) and K(+) concentrations of collagenase-disaggregated cells were 32 and 117 mEq/kg cell H(2)O, respectively. Cation concentrations of hyaluronidase cells were similar, but cells that did not respond to ADH had higher intracellular Na(+) concentrations. Cells unresponsive to ADH and Na(+) lack had high sucrose spaces and low transcellular membrane gradients of Na(+), K(+), and Cl(-). The results suggest that trypsin and EDTA disaggregation damage the active Na(+) transport system of the isolated cell. Certain EDTA techniques may also produce a general increase in permeability. Collagenase and hyaluronidase cells appear to function normally.


An immuno-cytopathogenic interaction between sensitized leukocytes and epithelial cells carrying a persistent noncytocidal myxovirus infection.


Neutralizing activity in nasal secretions and serum in resistance of volunteers to parainfluenza virus type 2.


A new measure of the sensitivity of electron spin resonance spectrometers.


Method for measuring hormonal effects on conversion of adenosine triphosphate to adenosine 3', 5'-monophosphate by isolated lipocytes.


Common codon characteristic of aminoacids capable to antagonize the antipolio action of guanidine and d-penicillamine.


Phosphorylase activity and glycogen levels in the adrenal cortex of rats subjected to acute ACTH stimulation.


The value of the angiotensin infusion test in the diagnosis of true renovascular hypertension.


Renal carcinoma. A 10-year study.

Renal carcinoma. A 10-year study.


Spectrophotometric determination of serum magnesium by eriochrome black T.


Measurements of thallium in biologic materials by atomic absorption spectrometry.


A comparison of properties of renin obtained from the kidney and uterus of the rabbit.


Abolition of circadian periodicity of plasma 17-OHCS levels in the cat.


Myogenic transmission of antral slow waves across the gastroduodenal junction in situ.


Enhancement of parainfluenza 2 virus hemagglutinin. A comparison was made of the three previously described methods of enhancement of parainfluenza 2 virus hemagglutinin (HA): ultrasonic oscillation, adsorption to erythrocytes and elution (AE), and Tween-ether (TE) treatment. TE treatment resulted in the maximal elevation of HA titer, complete loss of infectivity, and the maximal loss of heat stability of HA. Ultrasonic oscillation caused the least elevation of HA titer, minimal loss of infectivity, and the least loss of heat stability of both HA and infectivity. The effect of AE remained intermediate. It is suggested that the changes produced by these three methods are varying degrees of disruption of virus particles. Growth studies on parainfluenza 2 virus are also presented.


Production of nuclease-formine 5'-nucleotide by Aspergillus quercinus in a low phosphate medium. The production of ribonucleic acid (RNA)-depolymerase-forming 5'-nucleotides (5'-nuclease) was investigated with the fungus Aspergillus quercinus in media containing 68, 10, 5, 3, 1, and 0.5 mg of phosphorus per 100 ml. Yields were maximal with 5 mg of phosphorus per 100 ml. RNA-depolymerase-forming 3'-nucleosides (3'-nuclease) and phosphomonoesterase were maximal in media containing 1 and 0.5 mg of phosphorus per 100 ml. The 5'-nuclease was purified approximately 530-fold with a recovery of 84% by column chromatography on diethylaminoethyl-cellulose and by gel filtration through Sephadex G-100. The purified enzyme was capable of acting on both deoxyribonucleic acid and RNA, and the 5'-mononucleotides produced were identified by paper chromatography. The enzyme 5'-nuclease appears to be one of the repressible exonucleases that are active in the production of 5'-mononucleotides.


Rhinovirus plaque formation in WI-38 cells with methylcellulose overlay. A sensitive, reliable plaque assay system is described for five rhinoviruses using freshly prepared methylcellulose overlay and human embryonic diploid cells. Circular plaques with irregular edges, 2 mm in size, were formed by rhinoviruses 1A, 2, 6, and 13 after 6 or 7 days of incubation. A fifth rhinovirus, 17, formed a 1- to 2-mm feather plaque after 14 days of incubation. Plaque counts of rhinoviruses 1A and 13 were not affected by varying the pH of the overlay from 6.9 to 7.5. Plaque sizes and plaque-forming unit values of high passage rhinoviruses 1A and 13 were equivalent when tested at 26, 31, or 36 C. The rhinoviruses tested were sensitive to incubation at 40 C or heating at 50 C. Enhancement of plaques was observed when Mg(++) was incorporated into agar overlays, but enhancement did not occur when Mg(++) was added to methylcellulose overlays.


Survey of microorganism for the production of extracellular phytase. A culture enrichment technique was used to isolate phytase-producing microorganisms. Also, microorganisms from various culture collections were tested for their phytase-producing ability. A number of the Aspergillus niger group produced extracellular phytase which dephosphorylated calcium phytate in acidic solution. A soil isolate, A. ficuum NRRL 3135, produced the most active phytase in a cornstarch-based medium. Production of phytase was strongly repressed by inorganic phosphates and required a high carbon to phosphorus ratio in the medium.


Lecithinase production by Clostridium perfringens in chemicallly defined media.


Appearance of mouse-lethal toxin in liquid cultures of Bordetella pertussis. The mouse-lethal toxin present in liquid cultures of most smooth strains of Bordetella pertussis is known to originate in the cytoplasm of the organism but to be most lethal for mice when released into the supernatant fluid. It is also recognized that cell degeneration and lysis occur in liquid cultures during the stationary and decline phases of growth. For these reasons, it is generally believed that most of the toxicity demonstrable in liquid cultures at the time of harvest is released during the later stages of cultivation, when high alkalinity and aging of cells favor lysis. However, the results reported here have indicated that high levels of mouse-lethal toxicity arise during very early log phase and that the peak of toxicity is reached before the end of the log phase. No further increase in toxicity was observed during stationary and decline phases. The very early appearance of toxicity could not be explained by the presence in the inoculum of a proportion of dead and degenerating cells, and it is concluded that the toxin is produced mainly by actively growing cells. This was confirmed by tests on organisms growing in continuous culture. Electron-microscopic examination of cells from a very early log-phase culture revealed the presence of large numbers of small vesicles on the cell walls of about 5% of the population. It is suggested that these vesicles may be associated with the releases of toxin from living cells. It is concluded that no useful reduction in the toxicity of cultures would result from harvesting before the end of the log phase of growth.


Studies on human angiotensin.

Studies on human angiotensin.


Kinetics of renin-renin substrate.

Kinetics of renin-renin substrate.


Evidence for humoral factors participating in the renin-substrate reaction.


Individualities of vascular smooth muscles in response to angiotensin.


Mechanisms involved in the progressive pressor response to very small amounts of angiotensin in conscious rabbits.


Composition of tubular fluid in the macula densa segment as a factor regulating the function of the juxtaglomerular apparatus.


Studies on the preparation and properties of renin.


Relationship between intrarenal hydrostatic pressure and hemodynamically induced changes in sodium excretion.


Pulmonary capillary thrombosis in septicemia due to gram-positive bacteria.


The metabolic fate of vitamin D3-3H in chronic renal failure. The absorption and metabolism of vitamin D(3)-(3)H was studied in eight patients with chronic renal failure. Although the intestinal absorption of vitamin D(3)-(3)H was normal, the metabolic fate of the vitamin was abnormal as characterized by a twofold increase in fractional turnover rate, an abnormal accumulation of biologically inactive lipid-soluble metabolites, and the urinary excretion of both vitamin D(3)-(3)H and biologically inactive metabolites. Neither alterations in water-soluble vitamin D(3) metabolites nor qualitative abnormalities in protein-binding of vitamin D(3) were observed in the uremic subjects. Although hemodialysis proved ineffectual in reversing the observed abnormalities in vitamin D(3) metabolism and excretion, renal homotransplantation was completely successful in this regard. These experiments support the conclusion that the resistance to therapeutic doses of vitamin D often seen in patients with chronic renal failure and renal osteodystrophy results from an acquired defect in the metabolism and excretion of vitamin D.


Search for perinatal viral infection. A prospective, clinical, virologic, and serologic study.


Viral infections in hospitalized neonates.


Visceral involvement by herpes simplex virus in eczema herpeticum.


Niridazole in amebic dysentery and hepatic amebiasis.


A clinical trial of thiabendazole in strongyloidiasis.


Ceruminoma.

Ceruminoma.


Cytomegalovirus disease presenting as hepatitis.


Evidence suggesting a relationship between polyoma virus-induced transplantation antigen and normal embryonic antigen.


Electron microscopic studies of radiation-induced leukemia in mice: virus release following total-body x-ray irradiation.


Effects of hydroxyurea on polyoma virus replication.


Role of the mammary tumor virus in the immunogenicity of spontaneous mammary carcinomas of BALB/c mice and in the responsiveness of the hosts.


The role of the viral genome in oncogenesis.


Carcinogenesis by avian sarcoma viruses.


A possible role of transfer RNA in the mechanism of carcinogenesis.


Metabolic regulation and enzyme alterations in the Morris hepatomas.


Summary of discussion on neoplasms.

Summary of discussion on neoplasms.


Compression of digital nerves by Pacinian corpuscles. A report of two cases.


Familial fatal varicella.

Familial fatal varicella.


Fatal herpesvirus hominis (herpes simplex virus) infections in children. Clinical, pathologic, and virologic characteristics.


Hemodynamic balance and the kidney.

Hemodynamic balance and the kidney.


Acute polyneuritis requiring artificial respiration.


Salivary gland tumors occurring after radiation of the head and neck area.


Tumors of the deep lobe of the parotid gland.


In vivo activity of an inhibitor of influenza virus-induced ribonucleic acid polymerase.


Newer aspects of glucose fermentation in cancer growth and control.


Subcellular distribution of monoamine oxidase activity in rat liver and vas deferens.


Infusion of liver tumours.

Infusion of liver tumours.


Rate of inactivation of smallpox and vaccinia viruses by fixatives used in histological methods.


Oncogenic action of bovine papilloma virus in hamsters.


The bloodless greater omentum for myocardial revascularization.


Inappropriate antidiuretic hormone secretion in carcinoma of the lung.


Effect of long term in vivo application of phenanthroline. Penicillamine and further chelating agents on the synthesis of collagenous and non-collagenous proteins in fibrotic liver and wound granulation tissue.


Enzyme activities in liver, muscle, and adipose tissue of calves and steers.


The use of the pressor assay of renal venous blood in evaluation of renal hypertension.


Administrative implications of small group experiences.


Effects of aflatoxin B1 and other carcinogens upon nucleolar RNA of various tissues in the rat.


Patients speak out.

Patients speak out.


Parallel orientation of fibroblasts in vitro.


Musical rhythm motivation.

Musical rhythm motivation.


The nurse's role in the informal group.

The nurse's role in the informal group.


Functioning tumors of the pancreas.

Functioning tumors of the pancreas.


Our nurses are nursing.

Our nurses are nursing.


Geriatrics. Soviet Union.

Geriatrics. Soviet Union.


Factors in interpersonal and family relationships and alcoholism.


Psychiatric drugs and trends. The National Coordinating Council on Drug Abuse Education and Information.


Occupational therapy demonstration for nursing students.


Change in the phage type of Staphylococcus aureus as a result of lysogenizatio.


Comparative study on the interferon production by the leukocytes of healthy and leukaemic subjects.


Primary structure of insoluble tendon collagen. II. N- and C-terminal positional analysis of collagenolytic breakdown products of trypsin-pretreated collagen.


Nature of anaemia in rheumatoid arthritis. IX. Folate metabolism in patients with rheumatoid arthritis.


Respiratory mechanisms in the Flexibacteriaceae. I. Studies on the terminal oxidase system of Leucothrix mucor.


Cellular membranes: the isolation and characterization of the plasma and smooth membranes of HeLa cells.


Primary structure of insoluble tendon collagen. I. N- and C-terminal positional analysis of collagenolytic breakdown products of native collagen.


Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. I. Incorporation of choline into phosphatidylcholine of mitochondria and other membranous structures and effect of metabolic inhibitors.


Cryoglobulinemic neuropathy. Incidence and clinical characteristics.


Vertigo. An explanation--labyrinthine arrhythmia.


Performance characteristics of dust respirators, bureau of mines approved and non-approved types.


Fibrous and mineral content of cosmetic talcum products.


Endocrine abnormalities in bronchial carcinoma.


Respiratory disease in children caused by parainfluenza viruses. Description of an acute outbreak.


Slowly evolving widespread diffuse alimentary tract carcinoma (linitis plastica).


Incidence of primary carcinoma of the liver in the west of Scotland between 1949 and 1965.


Kinetic and equilibrium study of the adsorption of 2,4-dichlorophenoxy acetic acid on some surfaces.


Metabolic basis of aminonucleoside nephrosis in rats. I. Inhibition of alpha-oxoglutarate oxidation by aminonucleoside.


Excretion of catecholamine catabolites by normal children.


Radioimmunoassay of angiotensin.

Radioimmunoassay of angiotensin.


New enzymatic method for measurement of paraldehyde: correlation of effects with serum and CSF levels.


Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). I. Aflatoxins in vegetable protein feedstuffs.


Study of the antigenic specificity of Graffi leukemic cells.


Resistance to small amounts of Bittner mammary tumor virus in offspring of C57BL female mice with the virus.


Pyeloplasty by modified ureteroneopyelostomy.


Evaluation of polymyxin catheter lubricant and impregnated catheters.


Systemic lupus erythematosus complicated by coccidioidomycosis.


Mechanism of regression of tumours induced by polyoma virus in rabbits.


A foot and mouth disease syndrome in pigs caused by an enterovirus.


Functional interactions between biogenic amines, 3',5'-cyclic AMP and manganese.


Age variations of acid deoxyribonuclease activity in mouse liver nuclei.


The effect of tranylcypromine on synthesis of macromolecules and enzyme activities in neurons and glia.


Urinary bladder opacification following lymphangiography.


Patient isolator systems in cancer chemotherapy. The use of high-dose "nonabsorable" antibiotics in the reduction of bowel flora.


Cure of adult Wilms' tumor with distant metastasis? A case report.


Second primary neoplasms in children.

Second primary neoplasms in children.


Membrane systems of mitochondria. VI. Membranes of liver mitochondria.


Kinetic studies of temperature changes and oxygen uptake concomitant with substrate oxidation by mitochondria: the enthalpy of succinate oxidation during ATP formation by mitochondria.


Electroencephalographic changes after intravenous administration of antibiotics.


The plain chest radiograph in seventy-five cases of primary carcinoma of the liver.


Wilms' tumor and congenital aniridia.

Wilms' tumor and congenital aniridia.


Studies of bacterial susceptibility of heart valves.


Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects.


Blood pyruvate and lactate during febrile human infections.


Effects of genetic cellular resistance on cell transformation and virus replication in chicken hematopoietic cell cultures infected with avian myeloblastosis virus (BAI-A).


A genetic map of poliovirus temperature-sensitive mutants.


Replication of Sendai virus. I. Comparison of the viral RNA and virus-specific RNA synthesis with Newcastle disease virus.


Induction with hydroxylamine of guanidine resistance in poliovirus.


A complement fixing antigen from an M rhinovirus (brief report).


Enzyme-histochemical studies on the hypothalamus with specil reference to the supraoptic and paraventricular nuclei of squirrel monkey (Saimiri sciureus).


Two types of morphological transformation of bovine kidney cells infected in vitro with SV40.


Intestinal pain. Participation of other visceral sensations.


The effect of trauma on production of herpes interferon in guinea pigs.


Inhibition of mitochondrial electron transport by piericidin A and related compounds.


Effects of the solvent medium on polyvalylribonuclease aggregation.


The inhibition of microsomal glucose 6-phosphatase by metal-binding agents.


Pharmacologic actions of tetrodotoxin studied by direct perfusion of the sinus node.


Isolation from a salivary gland of granules containing renin and kallikrein.


Augmented sympathetic neurotransmitter activity in the peripheral vascular bed of patients with congestive heart failure and cardiac norepinephrine depletion.


Laboratory cultivation of some human parasitic amoebae.


Chemical and oxidative properties of coupled mitochondria from Aspergillus niger.


The interaction of polyoma DNA with DNA polymerase.


Mode of action of viomycin on Rhizobium meliloti.


19th Annual Meeting of the Histochemical Society, New Orleans, April 8-9, 1968. Symposium on critical evaluation of morphologic histochemical techniques for demonstrating enzymes. Evaluation of the specificity of enzyme histochemical reactions.


Cytomegaloviruses in stored urine specimens. A quantitative study.


Effect of ACTH on the electrical properties of adrenocortical cells.


Ultrastructural basis of excitation and inhibition in mammalian autonomic ganglia. An electron cytochemical study.


Granular cell myoblastoma of bronchus.

Granular cell myoblastoma of bronchus.


Mucoepidermoid tumors of salivary glands in Western India.


Bilateral ureteric metastases causing complete anuria.


Herpes simplex virus types 1 and 2 in various diseases.


Effects of collagenase on developing epithelia in vitro: lung, ureteric bud, and pancreas.


Daunomycin in the treatment of acute leukaemia and neoplastic diseases in childhood.


Extended care closes gaps in continuity of care.


Extramammary Paget's disease of the anus.


Biochemistry laboratory experiment. Polarized fluorescence.


A place for both the old and the new.

A place for both the old and the new.


Culture characteristics of brain neuroglial cells from chickens infected with Rous sarcoma virus.


Supraspinal control of transmission in the polysynaptic reflex pathway to montoneurones during sleep.


Raeder's paratrigeminal syndrome.

Raeder's paratrigeminal syndrome.


Oral poliovirus vaccination and breast feeding.


Granular cell myoblastoma. Report of three cases in the chest wall and review of the literature.


The conjugating mechanism in a case of etiocholanolone fever.


Hypertrophic neuropathy: a report of Dejerine-Sottas disease in two sibs.


Formation of giant polynuclear cells in cell lines by HVJ virus.


Treatment of diabetic neuropathy with diphenylhydantoin.


Primary carcinoma of the liver.

Primary carcinoma of the liver.


Optic neuritis.

Optic neuritis.


A study of the possible basis of age-dependent resistance of mice to poxvirus diseases.


The lactose synthetase particles of lactating bovine mammary gland. Preparation of particles with intact lactose synthetase. 1. The particulate form of lactating bovine mammary lactose synthetase activity is shown to be more highly organized than previously reported. 2. A novel method of shattering frozen mammary tissue with effective cell disruption is described. 3. The apparent subcellular distribution of lactose synthetase was shown to reflect the method of homogenization. 4. After mild homogenization particles associated with a high content of intact lactose synthetase activity sedimented in the lysosome size range between 5x10(4) and 3x10(5)g-min. 5. Lactose synthetase was dissociated and solubilized by VirTis homogenization and ultrasonic treatment. The activities and behaviour of UDP-galactose hydrolase, succinate dehydrogenase, beta-glucuronidase and phosphodiesterase I were compared. 6. Inhibition of UDP-galactose hydrolase by UTP and alpha-lactalbumin was observed.


The nature of soil humic acid.

The nature of soil humic acid.


Post-mortem glycolysis in ox skeletal muscle. Effect of pre-rigor freezing and thawing on the intermediary metabolism. 1. Ox sternomandibularis muscle was ;slow-frozen' by placing it in air at -22 degrees or ;fast-frozen' by immersion in liquid air or acetone-solid carbon dioxide. In all cases muscles were frozen pre-rigor. Changes in length, pH and the concentrations of P(i), creatine phosphate, hexose monophosphate (glucose 1-phosphate+glucose 6-phosphate+fructose 6-phosphate), fructose diphosphate (fructose 1,6-diphosphate+(1/2) triose phosphate), lactate, ATP, ADP, AMP and NAD(+) during freezing and during subsequent thawing were determined. In addition some measurements were made of the changes in alpha-glycerophosphate, 3-phosphoglycerate, 2-phosphoglycerate, phosphoenolpyruvate and pyruvate concentrations during slow freezing. 2. Appreciable shortening and marked changes in chemical composition took place during slow freezing but not during fast freezing. 3. During slow freezing the hexose monophosphate concentration fell and fructose 1,6-diphosphate and triose phosphate increased substantially. Increases also took place in 3-phosphoglycerate, 2-phosphoglycerate and phosphoenolpyruvate, but not in pyruvate. 4. On thawing, most of the chemical changes were similar to those in unfrozen muscle post mortem, but took place much more rapidly; loss of NAD(+) was particularly rapid. Fast-frozen muscle metabolized at a faster rate on thawing than did slow-frozen muscle. 5. The overall changes in length during freezing and thawing were about the same in slow-frozen as in fast-frozen muscle.


The lactose synthetase particles of lactating bovine mammary gland. Characteristics of the particles. 1. The conditions that promoted the solubilization of particulate lactose synthetase were effective for solubilizing the thiamine pyrophosphatase of the Golgi apparatus but differed from those effective for beta-glucuronidase or acid phosphatase of lysosomes. 2. Lactose synthetase-containing particles did not bind Mg(2+) or Cs(+) ions, suggesting that they are not related to endoplasmic reticulum membranes. 3. Intact lactose synthetase and thiamine pyrophosphatase particles banded isopycnically at a density of 1.143 in a sucrose gradient. The dissociated ;A' sub-unit of lactose synthetase, UDP-galactose hydrolase, p-nitrophenyl phosphate acid phosphatase, alkaline phosphatase and phosphodiesterase I were associated with particles of a broad density range from 1.12 to 1.20. Lysosomal enzymes beta-glucuronidase, arylsulphatase and beta-glycerophosphate acid phosphatase were associated with particles of density 1.20, 1.175 and 1.15 respectively. 4. Rate-zonal sedimentation studies indicated that lactose synthetase particles have S(20,w) values exceeding 24000s, corresponding to spherical particles of diameter exceeding 5.4x10(-5)cm. 5. Electron micrographs of lactose synthetase particles purified over 20-fold revealed small spherical bodies (0.1-0.5mu) resembling lysosomes, the smaller of which were attached to membranes, and larger heterogeneous spherical or oval bodies (0.7-1.8mu) resembling lipofuscin secretory granules. 6. The relationship between lactose synthetase particles and the Golgi origin of secretion granules is discussed.


The metabolism of 2-fluroic acid by Pseudomonas fluorescens F2.


The chemistry of flavines and flavorproteins. Photoreduction of flavines by amino acids. 1. Flavines are photoreduced through their triplet states by amines and amino acids (e.g. EDTA and dl-phenylglycine). The anaerobic photoreduction of FMN and several other flavines with dl-phenylglycine was analysed in terms of a detailed kinetic scheme. 2. The reaction produces equimolar amounts of benzaldehyde, carbon dioxide and reduced flavine. 3. The sensitivity of the rates to substituents in the dl-phenylglycine can be described by a Hammett rho-value of -1.1. 4. Phenylacetic acid behaves differently from dl-phenylglycine or benzylamine towards a series of flavines. 5. The photoreductions are quenched by several aromatic compounds. From the effects of light-intensity and temperature, and by comparison with potassium iodide quenching, it is concluded that inhibition by the aromatic compounds is not simply a collisional process. 6. FAD reacts more slowly than FMN both in the photoreduction and in dark reduction by NADH. Urea and dimethyl sulphoxide decrease the intramolecular interaction in FAD, but they have no effect on the rate of dark reduction of FAD compared with FMN. In contrast, the photoreduction of FAD is quicker in urea.


Mineral translocation in germinating wheat grain.


Comparison of interferon production in vitro by leukocytes from healthy and polycythaemic persons.


Examination in vitro of the virus inhibitory action of a new benzthiazole derivative.


Histochemical study of the cerebral cortex in rats thyroidectomised at birth.


Acetylcholine activation of carotid body chemoreceptor A fibers.


The influence of adrenocortical hormones and vitamins upon tryptophan metabolism in man.


The influence of oestradiol on the enzyme activities of regenerating vaginal epithelium in mice.


The mechanism of pathogenicity of Pseudomonas aeruginosa. V. Isolation and properties of the proteinases toxic for larvae of the greater wax moth Galleria mellonella L.


Enzymatic activity of basidiomycetes. II. Oxidation and dehydrogenation of NADH2 in Oudemansiella mucida.


Biosynthesis and composition of phosphatides in outer and inner mitochondrial membranes.


Reciprocal relations and proximity of bases in pyridine dinucleotides.


Paramagnetic resonance study of Nitric Oxide hemoglobin.


The enzymatic reduction of retinal to retinol in rat intestine.


Metabolism of pyridinium precursors of pyridine nucleotides in perfused rat liver.


Reactions of oxygenated cytochrome oxidase.


Unidirectional inhibition of glutamate dehydrogenase by metabolites. A possible regulatory mechanism.


On the mechanism of action of adrenocorticotropic hormone. The inhibitory site of cycloheximide in the pathway of steroid biosynthesis.


The glycopeptide linkage of ribonuclease B.


Suppression of testosterone and androstenedione porduction rates with dexamethasone in women with idiopathic hirsutsm and polycystic ovaries.


Cortisol binding affinity of plasma transcortin (CBA) as studied by competitive adsorption.


A testicular-interstitial-cell-stimulating gonadotrophin in a child with hepatoblastoma and sexular precocity.


Effects of prednisone on vitamin D metabolism in man.


Plasma corticotrophin estimations in Addison's disease and following adrenalectomy for Cushing's disease.


Diurnal variation in the concentrations of solvolyzable steroids in human plasma.


Lack of prolonged activity of a new ACTH preparation (DW-75) in human subjects.


Biosynthesis of 18-hydroxydeoxycorticosterone from deoxycorticosterone-4-14C by the human adrenal gland.


Effect of withdrawal of arginine and other amino acids on the synthesis of tumour and viral antigens of SV 40 virus.


The neutralization of Rous sarcoma virus.


The complement-fixation test for avian leukosis.


Requirement of arginine for the replication of herpes virus.


Tarsal tunnel syndrome.

Tarsal tunnel syndrome.


The hepatocarcinogenicity of some disubstituted 4-dimethylaminobenzenes.


Studies of liver glycogenoses, with particular reference to the metabolism of intravenously administered glycerol.


Studies in bullous diseases. Immunofluorescent serologic tests.


Functional differentiation of glycogenoses of the liver with respect to the use of glycerol.


Oxidation of NADH during contractions of circulated mammalian skeletal muscle.


Infectious bovine rhinotracheitis: correlation of fetal and placental lesions with viral isolations.


Infectious bovine rhinotrachetis: relationship of level of maternal antibody titer to incidence of fetal death and abortion.


The use of interferon production as a marker in the development of a modified strain of foot-and-mouth disease virus.


Electron microscopic studies on the development of vesicular stomatitis virus.


Growth of Sendai virus in organ cultures of mouse tissue.


Some factors affecting interferon production by foot-and-mouth disease virus in bovine tissue cultues.


Interference between modified and virulent strains of foot-and-mount disease virus.


Morphologic characteristics and nucleic acid type of transmissible gastroenteritis virus of pigs.


Comparative study of vesicular stomatitis virus and its plaque type mutant.


A carrier state in hamster-embryo cells with the Naples strain of phlebotomus fever virus.


Ionizing irradiation of foot-and-mouth disease virus and its ribonucleic acid.


Proteins of the human intervertebral disc. The association of collagen with a protein fraction having an unusual amino acid composition.


Electron spin resonane of iron-nitric oxide complexes with amino acids, peptides and proteins.


One-electron reactions in biochemical systems as studied by pulse radiolysis. I. Nicotinamide-adenine dinucleotide and related compounds.


Mechanism of oxidative phosphorylation in the chemoautotroph Nitrobacter agilis.


Cytochrome c552 and nitrite reduction in Escherichia coli.


Piericidin A and inhibition of respiratory chain activity in Escherichia coli K12.


Inhibitor of spinach chloroplast fructose-1,6-diphosphatase by MgATP--,MgADP-and magnesium pyrophosphate (MgP207--).


An effect of corticotropin on adrenal fatty acid synthesis.


Differentiation of various types of cholinergic and other spasmogenic actions on the isolated guinea-pig ileum.


The effect of piericidin A on energy-linked processes in submitochondrial particles.


Oxygen diffusion impairment as a sequel in a case of varicella pneumonia treated with adrenocortical steroids.


Spontaneous nephroblastomas in laboratory rats.


Neoplasia in nonhuman primates.

Neoplasia in nonhuman primates.


Diagnosis and handling of B virus in a rhesus monkey (Macaca mulatta).


Primary lung cancer. A twenty year experience.


Behavior in cattle of Iranian strains of foot-and-mouth disease virus subjected to serial passage in different kinds of cells.


Behavior of foot-and-mouth disease virus on serial passage in different kinds of cells. A contribution to experimental epidemiology at cell level.


Feline herpes virus: isolations and experimental studies.


Clinical and endocrinological aspects of virilizing adrenocortical adenoma.


Isolation of herpes-T virus from a spontaneous disease in squirrel monkeys (Saimiri sciureus).


The tween-ether treated hemagglutinin of parainfluenza 2 virus.


Distribution of virus neutralizing antibodies to different strains of rous sarcoma virus among "normal" chicks.


Experimental infection with Sendai virus in mice.


Direct electron-microscopy of organ culture for the detection and characterization of viruses.


Serum neutralization test with western equine encephalitis (WEE) and japanese encephalitis (JE) viruses using the agar cover slip (ACS) inoculation technique.


The fate of murine hepatitis virus (MHV-3) after intravenous injection into susceptible mice.


Changes in protein and nucleic acid metabolism in baby hamster kidney cells infected with foot-and-mouth disease virus.


Some improved techniques for the study of rhinoviruses using HeLa cells.


Nature of febrile response to intravenous injection of large amounts of herpes simplex virus in guinea pigs.


Temperature optima of mammalian and amphibian viruses in cell cultures of homeothermic and poikilothermic origin.


Selection of variants of rhinoviruses.

Selection of variants of rhinoviruses.


Formation of the thymine radical in irradiated DNA.


Techniques for DNA hybridization in vitro using non-radioactive DNA and DNA made radioactive by neutron activation, alkylation with radioactive alkylating agents, and by exchange with 3H2O.


Alterations in vitro of amino acid incorporating activity of liver preparations of non-starved normal and stress-induced rats.


Concerning the site of action of deoxyadenosine (deoxyadenosinetriphosphate) upon the synthesis of nucleic acids in the cancer cell.


Induction of deoxycytidylate deaminase and uridine kinase and activation of cellular DNA synthesis in the course of transformation of chicken embryo cells infected by Rous sarcoma virus in vitro.


Adrenal hyperaemia caused by corticotrophin.


An electron microscopic study on the possible site of production of ACTH in the anterior pituitary of mice.


Adrenal responses to corticotrophin in the presence of an inhibitor of protein synthesis.


In vitro corticosteroid biosynthesis in adrenals of rats uraemic after bilateral nephrectomy.


Steroid hormone production following adrenal stimulation in the rhesus monkey.


Plasma corticosteroid, plasma insulin and blood sugar of normal fasting and diabetic subjects with or without hypercorticism.


The effect of exogenous corticotrophin on steroid excretion in the newborn.


A clinical observation on the use of gonadotropins in the treatment of ulcerative colitis.


Histochemical study of aminopeptidase in malignant neoplasms of the female genitals.


Topical antibiotic spray in contaminated crush wounds in animals.


Alterations in reticulo-endothelial functions as produced by the administration of bacterial toxins.


Drug withdrawal state. An EEG sleep study.


Evidence for a single structural polypeptide in foot-and-mouth disease virus.


Quantitative haemadsorption. A fast and reliable screening test for anti-myxoviral agents.


Management of esophageal lesions caused by chemical burns.


Pancreaticoduodenectomy for Zollinger-Ellison syndrome.


Tumours of the liver, kidney and lungs in rats fed Encephalartos hildebrandtii.


Cell-free transmissible leukoses in Syrian hamsters, probably of viral aetiology.


Microvascular effects of vasoactive agents in shock.


Congenital cytomegalovirus infection treated with idoxuridine.


Long-acting synthetic corticotrophin in dermatology.


Effect of halothane and methoxyflurane anaesthesia on plasma cortisol concentration in relation to major surgery.


Oxidation of exogenous reduced nicotinamide adenine dinucleotide by liver mitochondria from essential fatty acid-deficient rats.


Effect of protein intake on tissue amino acid levels and the enzymes of serine biosynthesis in the rat.


Extended hemodialysis in children with chronic renal failure.


The comparative effect of 6 alpha-fluoroprednisolone, 6 alpha-methylprednisolone, and hydrocortisone on linear growth of children with congenital adrenal virilism and Addison's disease.


Impulse transmission via nicotinic and muscarinic pathways in the stellate ganglion of the dog.


Actions of anticholinesterase agents upon ganglionic transmission in the dog.


A study of the alteration in receptor activity of the rat fundal strip by urea.


Malignant transformation in vitro by oncogenic viruses.


People who care.

People who care.


The second messenger.

The second messenger.


A simple, sensitive method for the assay of adenyl cyclase.


Human circadian rhythms and the 48 hour day.


Physical exercise and alcohol metabolism in man.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1968.


Genital infection with Herpesvirus hominis types 1 and 2 in children.


Glycogen storage in a hepatoma: dephosphophosphorylase kinase defect.


Radiation therapy of brachial plexus syndrome from breast cancer.


Persistent angiographic abnormalities after cure of malignant trophoblastic disease.


Treatment of Clostridium welchii infection with hyperbaric oxygen.


The epithelium in wound healing.

The epithelium in wound healing.


Conversion of 14C-labeled geranylgeranyl pyrophosphate to phytoene by a soluble tomato plastid enzyme system.


Biosynthesis of trans-geranylgeranyl pyrophosphate in endosperm of Echinocystis macrocarpa Greene.


Effect of menadione on the electron transport pathway of yeast mitochondria.


Studies on the synthesis of fatty acids by a beef heart mitochondrial enzyme system.


A phosphatidylinositol kinase in rat kidney cortex.


The isolation of infectious bovine rhinotracheitis virus from bovine semen.


25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.


A dimer of diphosphopyridine nucleotide.


5-carboxymethyluridine, a novel nucleoside derived from yeast and wheat embryo transfer ribonucleates.


Fractionation of transfer ribonucleic acid on a methylated albumin-silicic acid column. I. Preparation of the column.


Feedback inhibition of glutamine synthetase of Neurospora crassa by nicotinamide-adenine dinucleotide.


Fructose diphosphatase from rabbit liver. X. Isolation and kinetic properties of the enzyme--adenosine monophosphate complex.


Purification, properties, and allosteric activation of nucleoside diphosphatase.


The phosphofructokinase of Dictyostelium discoideum.


Parathyroid hormone and renal cell metabolism.


Amino acid transfer factors from yeast. II. Interaction of three partially purified protein fractions with guanosine triphosphate.


The cyclic phosphodiesterases (3'-nucleotidases) of the enterobacteriaceae.


Histoenzymatic activities of three KB cell lines latently infected by Myxovirus parainfluenzae, type 3, strain EA-102. I. Aminopeptidase activity.


Histoenzymatic activities of three KB cell lines latently infected by Myxovirus parainfluenzae, type 3, strain EA-102. II. Hydrolytic and oxidative enzyme activity.


Variation in susceptibility of chick embryo tissues to infection with Rous sarcoma virus in vitro.


Action of pyridine-2-aldoxime methochloride (PAM) on neuromuscular transmission in vitro and in vivo.


Cylindroma (remote) and giant follicular lymphoblastoma with paraplegia following radiation therapy in a 62-year-old woman.


Encephalo-myelo-radiculo-neuropathy.

Encephalo-myelo-radiculo-neuropathy.


Hepatocarcinogenicity of the herbicide maleic hydrazide following parenteral administration to infant Swiss mice.


Growth of the XV40-adeno 7 hybrid virus in human diploid cells.


Virus particles in bone marrow megakaryocytes and susceptibility of mice to virus-induced leukemia.


The tarsal tunnel syndrome.

The tarsal tunnel syndrome.


Potentiation of the biologic activity of ACTH by human plasma. A preliminary study.


Effect of adrenocorticotropin and glucocorticoids on insulin secretion.


Malignant tumors of childhood masquerading as acute surgical conditions.


Toxicity of combines histamine and serotonin in normal, pertussis -sensitized, and beta-adrenergically blocked mice.


Approach to tumors of the nose, nasopharynx and paranasal sinuses.


A comparison between the inhibitory effect of perchlorate on iodide and pertechnetate concentrations in saliva in man.


Egg transmission studies of type II leukosis infection (Marek's disease).


Comparative histological and sputumcytological studies of the bronchial epithelium in inflammatory and neoplastic lung disease.


The effect of hypophysectomy on the lipid pattern of the adrenal cortex in mice with spontaneous adrenocortical lipid depletion. A histological study.


Growth in rat of a sarcoma derived from rat kidney cells transformed in vitro by SV40.


The effect of an oral contraceptive as a preparatory mechanism in the generalized Shwartzman reaction in rabbits.


Types of contacts in vitro between rous mouse tumour cells and chicken fibroblasts as studied with the electron microscope.


Investigations on the enzymes and toxins of staphylococci. Separation of lipase from phosphatase and spectophotometric analysis of the "egg yolk reaction".


Polybactrin soluble in neurosurgical practice.


Homotypic and heterotypic antibody response in infants to adenovirus vaccine.


Studies on the pathogenesis of African swine fever. I. Quantitative studies on the sequential development of virus in pig tissues.


EPR studies of psychotropic drug interactions at cell membranes.


Quantitative studies on the quality, effects of aggregation and thermal inactivation of vesicular stomatitis virus.


Inhibitory effects evoked through ventral reticulospinal pathways.


The action of phenothiazines and some pyridazone derivatives on respiratory enzymes in vivo and in vitro.


Respiratory virus infections other than influenza.


Pathophysiological aspects of human adjustment to cold.


Serologic surveys of Arctic populations and some virus diseases of interest.


The triplet state of pyridoxal.

The triplet state of pyridoxal.


Some properties of the polynucleotide phosphorylase and ribonuclease II of Escherichia coli 1113B.


Site of action of adrenocorticotropic hormone (ACTH) in adrenal cell cultures.


NADH oxidase in blue-green algae.

NADH oxidase in blue-green algae.


Induction of cellular DNA synthesis in chick embryo fibroblasts infected with Rous sarcoma virus in culture.


Acute necrotizing lepromatous lymphadenitis: an erythema-nodosum-leprosum-like reaction in lymph nodes. Histological examination of lymph-node biopsy specimens in 12 patients with erythema nodosum leprosum showed almost complete replacement of the node by lepromatous granuloma, together with considerable polymorph infiltration. Ziehl-Neelsen staining demonstrated numerous Mycobacterium leprae present in the nodes. The majority of these patients were very ill, and responded to prednisolone or corticotrophin.It is suggested that the histological appearances may represent an intensive inflammatory response in the lymph nodes followed by avascular aseptic necrosis.


Herpesvirus hominis infections.

Herpesvirus hominis infections.


Bilateral Wilms' tumor. Diagnosis and management.


Antibiotics--1968. Review.

Antibiotics--1968. Review.


The Synacthen test of adrenal cortical function in children.


Pathogenesis of Rous sarcoma virus in the chick embryo with particular reference to vascular lesions.


Altered properties of Fujinami-virus-infected duck cells and murine sarcoma virus-infected rat cells.


The molecular and electronic structure of vitamin B12r, cobaloximes(II), and related compounds.


The intraspinal distribution of some depressant amino acids.


Relation of dreaming and REM sleep: the effects of REM deprivation under two conditions.


Lipid composition of glial cells isolated from bovine white matter.


Experience in a growth and development clinic with particular reference to growth hormone deficiency.


Paget's disease of the nipple.

Paget's disease of the nipple.


Pancreatic islet cell tumour demonstrated by aortography.


Virus infections.

Virus infections.


Sleep and dream patterns in twins. Markov analysis of a genetic trait.


Control of epinephrine synthesis by the pituitary and adrenal cortex: possible role in the pathophysiology of chronic stress.


Electron paramagnetic resonance signal produced by ferricyanide in photosynthetic plant materials.


Encephalopathy and fatty degeneration of the viscera in childhood: II. Report of a case with isolation of influenza B virus.


In vitro uptake of ascorbic acid-1-14-C by adrenal glands of different species of animals.


Porcine enterovirus antisera prepared in chickens.


Reaction of young adult sheep to vaccination and infection with myxovirus parainfluenza 3.


An improved method for the isolation and identification of bluetongue virus by intravenous inoculation of embryonating chicken eggs.


The displacement of stages 4 and REM sleep with a full night of sleep.


The unusual in urology.

The unusual in urology.


Insect salivary glands: stimulation of fluid secretion by 5-hydroxytryptamine and adenosine-3',5'-monophosphate. Low concentrations (10(-9)M) of 5-hydroxytryptamine increase the rate of fluid secretion by isolated salivary glands of adult Calliphora. 5-Hydroxytry ptamine is present in Calliphora brain. Adenosine-3',5'-monophosphate (cyclic AMP) also stimulates fluid secretion and may be involved in the mode of action of 5-hydroxytryptamine.


Electron spin resonance investigations on ferricytochrome c compounds.


Peripheral inhibition n crustacean muscle.


The influence of Bordetella pertussis on the kinetics of antibody production to sheep red blood cells in NMRI mice.


On the mannophosphoinositides of Mycobacterium 607.


Separation by gas-liquid chromatography of the glycerol and erythritol glycosides of D-glucopyranose and maltose. Periodate and methylation studies on a synthetic "polymaltose".


Analysis of antibiotics by gas chromatography. I. Lincomycin.


Separation, identification and estimation of Cr3 complex ions. Thin-layer chromatography and diffuse reflectance spectroscopy.


Subclinical cytomegalovirus infections and cytomegalovirus mononculeosis after open heart surgery.


Aftercare of the psychiatric patient: an 1847 view.


Lung cancer following atomic radiation.

Lung cancer following atomic radiation.


Ethambutol in re-treatment of pulmonary tuberculosis.


Kinetic and spectrophotometric studies on the renaturation of deoxyribonucleic acid. The kinetics of the renaturation of Escherichia coli DNA in 0.4-1.0m-sodium chloride at temperatures from 60 degrees to 90 degrees have been studied. The extent of renaturation was a maximum at 65 degrees to 75 degrees and increased with ionic strength, and the rate constant increased with both ionic strength and temperature. The energy and entropy of activation of renaturation were calculated to be 6-7kcal.mole(-1) and -40cal.deg.(-1)mole(-1) respectively. It has been shown that renaturation is a second-order process for 5hr. under most conditions. The results are consistent with a reaction in which the rate-controlling step is the diffusion together of two separated complementary DNA strands and the formation of a nucleus of base pairs between them. The kinetics of the renaturation of T7-phage DNA and Bordetella pertussis DNA have also been studied, and their rates of renaturation related quantitatively to the relative heterogeneity of the DNA samples. By analysis of the spectra of DNA at different stages during renaturation it was shown that initially the renatured DNA was rich in guanine-cytosine base pairs and non-random in base sequence, but that, as equilibrium was approached, the renatured DNA gradually resembled native DNA more closely. The rate constant for the renaturation of guanine-cytosine base pairs was slightly higher than for adenine-thymine base pairs.


Aspects of the chemistry of D-glyceraldehyde 3-phosphate dehydrogenase. Crystalline d-glyceraldehyde 3-phosphate dehydrogenase from lobster tail contains 4 moles of NAD(+) bound and reacts specifically with 4 moles of iodoacetic acid/mole of tetramer. The essential thiol group of d-glyceraldehyde 3-phosphate dehydrogenase appears to react with iodoacetic acid with a rate constant for the overall process that is independent of the extent of carboxymethylation. The d-glyceraldehyde 3-phosphate dehydrogenase-NAD(+) absorption band has a variable molar extinction coefficient in the presence of phosphate that may be correlated with a proton dissociation of pK 6.86. The binding of NAD(+) to d-glyceraldehyde 3-phosphate dehydrogenase weakens as alkylating agents react with the enzyme, and NAD(+) promotes the reactivity of the essential thiol group. It is suggested that, on binding to d-glyceraldehyde 3-phosphate dehydrogenase, NAD(+) lowers the pK of the essential thiol group, resulting in a catalytic role of NAD(+) in the reaction catalysed by d-glyceraldehyde 3-phosphate dehydrogenase. If this theory is correct, then it is likely that a proton will be liberated during the phosphorolysis of the acyl-enzyme rather than in the redox step.


Electron paramagnetic resonance observations on biogenic semiquinone and 5-methyl phenazinium radicals.


Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. 1. The ribosomal components in the postmitochondrial supernatant of a rat hepatoma (hepatoma 7800) and the corresponding host liver were examined for diversity and functional competence. 2. The ;free' and ;membrane-bound' polyribosomes of both tissues were equally active in vivo and had equilibrated with newly synthesized ribosomes 4hr. after administration of [6-(14)C]orotic acid. 3. The inactive monomer-dimer pool in hepatoma 7800 was unattached to membranes and a larger fraction of the polyribosomes was free in hepatoma than in liver. 4. By using sensitivity to puromycin as a criterion, evidence was obtained that most of the polyribosomes in hepatoma 7800 were active in vivo. 5. Actinomycin, azaguanine and carbon tetrachloride caused marked conversion of polyribosomes into inactive monomers and dimers in the host liver and moderate conversion in the hepatoma. 6. Significant accumulation of ferritin and shifts in the mean polyribosome size to the lighter species occurred in the host liver of rats bearing large hepatomas.


A histochemical study of the reticuloendothelial system of human marrow--its possible transport role.


Tetanus toxin and spinal inhibition.

Tetanus toxin and spinal inhibition.


Effects of ACTH, dexamethasone and asphyxia on electrical activity of the rat hypothalamus.


Presynaptic inhibition of cuneate transmission by widespread cutaneous inputs.