Lipids of plasma membranes of monkey and hamster kidney cells and of parainfluenza virions grown in these cells.


The structure of the mammary tumor virus.


Binding of NAD+ to rabbit-muscle glyceraldehydephosphate dehydrogenase as studied by optical rotatory dispersion and circular dichroism.


Nucleotidase activities in the soluble fraction of rat liver homogenate. Partial purification and properties of a 5'-nucleotidase with pH optimum 6.3.


Relation of cerebrospinal fluid circulation to the ACTH-suppressing effects of corticosteroid implants in the rat brain.


Responsiveness to lipolytic hormones, and inactivation of adrenocorticotropin, by adipose tissue slices and free fat cells from different mammalian species.


Lipolytic activity of synthetic porcine secretin.


Immunoassayable insulin content of subcellular fractions of rat islets.


Stimulation of thyroid hormone secretion by dibutyryl cyclic-AMP.


Adrenal cells in tissue culture. IV. Use of an inhibitor of steroid synthesis for the study of ACTH action.


Acute effect of overtransfusion of plasma renin activity in the rat.


Effect of corticotropin-releasing factor, dexamethasone and actinomycin D on the release of ACTH from rat pituitaries in vivo and in vitro.


Adrenal sterol metabolism in the hamster following ACTH and cortisol administration.


Dexamethasone suppression of ACTH release: effect of the interval between steroid administration and the application of stimuli known to release ACTH.


Suppression of the hypothalami- c-pituitary-adrenal axis in the newborn dog.


Intra- oral removal of large juvenile angiofibroma.


"Retrograde" metastasis of primary carcinoma of the liver to the stomach.


Lipid abnormalities in foam cell reticulosis of mice, an analogue of human sphingomyelin lipidosis. The lipid changes in the inheritable foam cell reticulosis of mice discovered by Lyons, Hulse, and Rowe have been reexamined. The major abnormality in thymuses from homozygous-abnormal animals has been identified as an increase in the concentration (per milligram of protein) of sphingomyelin and cholesterol. This increase is associated with normal sphingomyelin-cleaving activity. The lipid compositions of the liver and spleen in the homozygous-abnormal animal and of the thymus in the heterozygous-abnormal mouse are normal. The disorder appears to be chemically analogous to those forms of human sphingomyelin lipidosis (Niemann-Pick disease) that are not accompanied by a decrease in tissue sphingomyelinase.


Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids. Hepatic microsomal preparations from nonfasted, fasted, and fasted-fed rats were employed, together with cofactors, in studies of 9-desaturation of stearate-1-(14)C and 6-desaturation of linolenate-1-(14)C. Prior fasting sharply reduced 9-desaturation but did not affect 6-desaturation; feeding restored 9-desaturation. Position of desaturation was determined by permanganate-periodate oxidation and separation of the dicarboxylic acids. Feeding after fasting stimulated both desaturase systems but either dl-ethionine or actinomycin D prevented this. Dietary carbohydrate or saturated fat increased 9-desaturation and dietary protein increased 6-desaturation. Insulin treatment of nonfasted rats increased 9-desaturation but not 6-desaturation. High dietary unsaturated fat (20% safflower oil) stimulated 6-desaturation but inhibited the 9-desaturation response to feeding. The results indicate that the two desaturases are distinct and are inducible in response to different substances.


Preparative thin-layer and column chromatography of prostaglandins. Chromatographic methods are used to identify various monounsaturated PGs (prostaglandins).  TLC (thin-layer chromatography) and column chromatography are described in detail.  These systems were developed specifically for separating epimers of PGE1 and PGF1, but they are useful in separating some of the known natural PGs as well.  A table presents information on identification of the various PGs with neutral silica and acidic silica.  The results of these laboratory experiments indicate that 1 ug-1g of PG can be purified by chromatographic methods with little or no loss due to irreversible adsorption or rearrangement if proper precautions and solvent systems are used.  TLC seems to be useful in distinguishing diastereomers of PGs.  Relative mobilities of the various hydroxy diastereomers are not changed by the solvent systems or by esterification.


Hemorrhagic lesions produced by Claude's chicken tumor-10 virus.


Evidence for separate monoglyceride hydrolase and triglyceride lipase in post-heparin human plasma. Post-heparin plasma contains an enzyme or enzymes with both triglyceride lipase (TGL) and monoglyceride hydrolase (MGH) activities. A simple and reproducible radioactive assay for measurement of MGH activity was developed and used, with a previously reported assay for TGL, to study lipolysis in plasma. After the injection of heparin, enzymatic activity against both tri- and monoglycerides appeared and disappeared from plasma at approximately the same rates. However, in contrast to TGL activity, MGH activity was: (a) much greater, (b) considerably less heat-sensitive, (c) unaffected by three inhibitors (NaCl, protamine, and pyrophosphate), (d) not influenced by radical changes in fat and carbohydrate content of the diet, and (e) normal in familial Type I hyperlipoproteinemia. The dichotomy between MGH and TGL activities in patients with genetic deficiency of TGL constitutes strong evidence that these are two different enzymes. The findings further indicate that when post-heparin lipolytic activity is measured for the purpose of detecting TGL deficiency, it may be necessary to perform the assay with a substrate free from partial glycerides.


Characterization of two BALB-c infant thymus cell lines infected with lympholeukemogenic virus.


Detection of antibodies against the mammary tumor virus with the antiglobulin consumption test.


Paget's disease of the breast: the influence of the presence or absence of an underlying palpable tumor on the prognosis and on the choice of treatment.


Regeneration of the liver after hepatectomy.


The amoebicidal activity and toxicity of natural emetine, (plus or minus)-2-dehydroemetine and (--)-2-dehydroemetine.


Total lipodystrophy.

Total lipodystrophy.


Formation of extracellular adenosine triphosphate by tumour cells.


Quantum yield for the photoproduced electron paramagnetic resonance signal in chromatophores from Rhodospirillum rubrum.


The 5'-linked termini of plant ribosomal ribonucleic acids.


The state of iron in hemerythrin. A Mössbauer study.


The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.


Pyridine coenzymes. VII. Catalysis of the hydration of the reduced form by iodoaromatic compounds.


The purification and properties of rat muscle glycogen phosphorylase.


The effect of nerve stimulation on catecholamines taken up in adrenergic nerves after reserpine pretreatment.


Blockade of the phosphorylase alpha-activating effects of catecholamines and adenosine 3',5'-monophosphate (cyclic AMP) in high K+ or choline buffer media.


Conformational changes in the molecular control of muscle contraction.


Phosphodiesterase in psoriasis.

Phosphodiesterase in psoriasis.


The effect of nerve stimulation on the uptake of noradrenaline into the adrenergic nerve terminals.


Inhibitory processes in gustation.

Inhibitory processes in gustation.


Relation of afferent nerve excitability to impulse generation in the frog spindle.


Hemodynamic changes during sleep in hypertensive patients.


Age at menarche: a new method of prediction and retrospective assessment based on hand x-rays.


Decreased rate of synthesis of immunoglobulin (IgG) in rats infected with moloney leukemia virus.


ATP level and control of glycolysis in Novikoff ascites-hepatoma cells.


An analysis of the polyoma virus DNA-RNA hybridization reaction in vitro.


20 Beta-hydroxysteroid:NAD oxidoreductase activity towards 3 beta-hydroxypregn-5-en-20-one sulphate and related free steroids.


Visualisation in the electron microscope and size of RNA from animal cells.


Interactions of glucagon and insulin on the metabolism of perfused livers from fasted rats.


Reaction of amino acid-tRNA synthetases with 2'-deoxyadenosine triphosphate.


Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine.


Discussion on scope and application of current audiometric tests.


Adenyl cyclase in cell-free extracts of Escherichia coli.


Biochemistry of cerebral tumours: sodium, potassium, calcium, phosphorus, magnesium, copper and sulphur contents of astrocytomata, medulloblastomata and glioblastomata multiforme.


Structural and functional abnormalities in mitochondria isolated from ischemic dog myocardium.


Changes in phospholipid composition of human aorta with age.


Isolation of highly purified human and bovine brain endothelial cells and nuclei and their phospholipid composition.


Phospholipid composition of human, bovine and frog myelin isolated on a large scale from brain and spinal cord.


Variations among vertebrates of lung phospholipid case composition.


Motor nerve conduction velocity and the electromyograph in pellagra.


Central nervous system lesions that block release of ACTH caused by traumatic stress.


Congenital fistula of the lacrimal sac.

Congenital fistula of the lacrimal sac.


Area of pons necessary for traumatic stress-induced ACTH release under pentobarbital anesthesia.


Implications of redistribution equilibria in reactions of biological importance.


Effect of ascorbic acid on pulmonary silicosis of guinea pigs.


Ultrastructural characteristics of adenoid cystic carcinoma of salivary glands.


The resident's page.

The resident's page.


Aneurysm of the internal carotid artery presenting in the middle ear.


Nasopharyngeal angiofibroma.

Nasopharyngeal angiofibroma.


Determination of the molecular weight of proteins, esterases, and basic phospho-monoesterases in the hemolymph of Galleria mellonella L. prepupa and pupa using a thin-layer chromatography.


Simian virus 40 infection of uninoculatedAfrican green monkeys (Cercopithecus aethiops) revealed by repeated cell passages.


Allergic encephalomyelitis: inhibition of cellular passive transfer by exogenous and endogenous steroids.


Antagonism of polymyxin B and kanamycin sulfate by Liquoid (sodium polyanetholsulfonate) in vitro.


Surface structure of foot-and-mouth disease virus.


Immunological relationship between herpes simplex and varicella-zoster viruses demonstrated by complement-fixation, neutralization and fluorescent antibody tests.


Alkaline degradation of polyoma virus.

Alkaline degradation of polyoma virus.


The relation of the DNA polymerase to an early temperature-sensitive event in the replication of variola virus.


A possible subunit structure of Rous sarcoma virus RNA.


The immunological specificity of thymidine kinases in cells infected by viruses of the herpes group.


Feline herpesvirus infection in fused cultures of naturally resistant human cells. Feline herpesvirus (FHV) attaches to, but does not penetrate, naturally resistant human embryonic lung cells. When the cells with attached virus are subsequently fused with inactivated Sendai virus, FHV causes characteristic cytopathic effects, but no infectious virus can be recovered from the infected cells.


Replication of poliovirus in phytohemagglutinin-stimulated human lymphocytes. Poliovirus replication has been studied in human lymphocytes during the course of blastogenesis under phytohemagglutinin (PHA) stimulation. Enhancement of virus replication in PHA-stimulated leukocyte cultures was due to an increase in number of virus-producing cells. Virus yield was approximately 10 plaque-forming units (PFU) per producing cell, both in stimulated and in nonstimulated cultures. Adsorption and penetration studies showed that freshly drawn lymphocytes (unlike other leukocytes) were resistant to virus infection, but they became susceptible to the virus during PHA stimulation. Also, the eclipse of the virus after penetration was enhanced during blastogenesis of the lymphocytes. Our findings suggested that the monocytes in the leukocyte cultures were infected initially. In PHA-stimulated cultures, the virus then spread to lymphocytes which became susceptible to virus infection during blastogenesis. Polymorphonuclear cells died within 24 to 48 hr after initiation of the cultures and apparently could not support poliovirus replication.


Heterokaryon formation of simian virus 40-transformed cells in the presence of ultraviolet-irradiated Sendai virus. Most simian virus 40-transformed mouse kidney lines form heterokaryons with CV-1 cells in the presence of ultraviolet-irradiated Sendai. However, two nonyielder lines, mKS-U2 and mKS-U20, fuse poorly.


Substiuted sialic acid prosthetic groups as determinants of viral hemagglutination. Inhibitors of hemagglutination by type A2 influenza virus and a recently isolated strain of type B influenza virus were separated by sucrose density gradient centrifugation and agarose gel filtration from horse serum. Using selected reagents, it was demonstrated that the active substituent on the horse serum inhibitor of A2 influenza virus was 4-O-acetyl-N-acetylneuraminic acid; however, the active substituent on the inhibitor of the influenza B virus was shown to be N-acetylneuraminic acid (NANA). Sodium metaperiodate treatment of a component of horse serum resulted in a 10 to 15-fold enhancement of inhibitory activity against the type B virus, whereas the A2 inhibitor was completely destroyed. Since this enhancement did not occur with influenza B viruses isolated prior to 1965, it was considered that this sensitivity to an oxidized NANA glycoside may have been a reflection of an antigenic change which occurred at that time. The use of different virus strains and selected chemical reagents to define the important sialic acid prosthetic groups active in inhibition was described.


Potentiation by an antagonist.

Potentiation by an antagonist.


Serum immunoglobulin levels in postmature infants.


Viral-induced enzymes and the problem of viral oncogenesis.


The role of cyclic AMP in hormone actions.


Granular cell myoblastoma of larynx. Two case reports.


Salivary gland neoplasms in childhood.

Salivary gland neoplasms in childhood.


Effects of sodium deficiency, potassium deficiency and uremia upon the steroidogenic response of rat adrenal tissue to serotonin, potassium ions and adrenocorticotropin.


The adrenal gland and lactogenesis.

The adrenal gland and lactogenesis.


The ultrastructure of brown adipose tissue in perinatal rats.


Effects of morphine intoxication on brain catecholamine neurons.


Influence of respiration, stroke volume, and heart rate on pulmonary capillary pulsatility.


Ferrous-activated nicotinamide adenine dinucleotide-linked dehydrogenase from a mutant of Escherichia coli capable of growth on 1, 2-propanediol. A nicotinamide adenine dinucleotide-linked dehydrogenase has been partially purified from a mutant of Escherichia coli K-12 able to grow on l-1,2-propanediol as carbon and energy source. This enzyme catalyzes the dehydrogenation at carbon 1 of l-1,2-propanediol, glycerol, 1,3-propanediol, ethylene glycol, and ethyl alcohol. The purified protein requires added ferrous or managanous ions. The V(max) and the apparent K(m) for a given substrate vary with the particular metal used.


Direct fluorescence quantitation on thin-layer chromatograms.


The role of propionic acid as a precursor of methylmalonic acid in normal and vitamin B12-deficient man.


Alpha toxoid of Clostridium perfringens. I. Purification and toxoiding of alpha toxin of C. perfringens.


Tumor development and induction of resistance by Rous sarcoma virus in Japanese quail.


Purification of beta-toxin of Clostridium perfringens type C.


Colitis--its etiology, diagnosis and treatment.


Clinical and laboratory differentiation of recurrent intraoral herpes simplex virus infections following fever.


Adrenal corticosteroids in submaxillary fluid.


Virus-associated gain and loss of proliferative and neoplastic properties of normal and virus-transformed diploid cell lines.


Inactivation of Rous Sarcoma Virus preparations detected by density gradient centrifugation.


Immunological studies of choriocarcinoma. IV. The antigenicity of trophoblast.


Alternate-day prednisone therapy. Evaluation of delayed hypersensitivity responses, control of disease and steroid side effects.


Clinical pathologic correlations of copper.


Family treatment of folie à deux.

Family treatment of folie à deux.


Psychiatric aftercare in a general hospital: some basic principles and their implications for community psychiatry.


Amebiasis in Peace Corps volunteers. Clinical profile of amebiasis in American volunteers in India.


Generation of adrenergic and cholinergic potentials in sympathetic ganglion cells. Norepinephrine elicited a hyperpolarizing response, and acetylcholine (during nicotinic blockade) elicited a depolarizing one. Both responses showed no increase in membrane conductance. The norepinephrine response was suppressed by initial depolarization; the acetylcholine response (frog cells); by hyperpolarization. These neurotransmitters apparently can activate electrogenic mechanisms which do not involve movement of ions down their electrochemical gradients.


Clinical application of a simple, specific bioassay technique for measuring renin activity.


Effect of botulinum toxin on speed of skeletal muscle contraction.


A simple method for the detection of low concentration of viruses in large volumes of water by the membrane filter technique.


Hemodynamic patterns during desynchronized sleep in intact cats and in cats with sinoaortic deafferentation.


Sympathetic ganglionic transmission and the cardiovascular changes of the defense reaction in the cat.


Phosphatidate phosphohydrolase in frog intestinal tissue.


Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda).


The evolution of endopeptidases--V. Common and different traits of bovine and crayfish trypsin.


Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. 3. A method of increasing the frequency of cell fusion.


Composition and metabolism of phospholipids in cataract.


Biochemical and pathological changes in rats fed brominated cottonseed oil for 80 days.


Alcohol still much in demand.

Alcohol still much in demand.


Antibody in polyacrylamide gel, a solid phase reagent for radioimmunoassay.


The murine runting syndrome and neoplasia.


The antibody activities of 19S and 7S fractions from rabbit antisera to Bordetella pertussis.


Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate.


Mitotic and nonmitotic multiple-layered perfusion cultures. Cell types in addition to those previously described (Kruse et al. 1963. J. Nat. Cancer Inst. 31:109; Kruse and Miedema. 1965. J. Cell Biol. 27:273) were found to form multiple-layered cultures by perfusion-culture technique. Dense populations containing 43 x 10(6) embryonic rat muscle (NF-ER) cells, 23 x 10(6) diploid human tonsillar (NF-JAM) cells, 77 x 10(6) human pleural effusion isolate (RPMI 2650) cells, 35 x 10(6) embryonic diploid human lung (Flow 2000) cells, 21 x 10(6) bovine lung (FB4BM) cells, 108 x 10(6) bat lung (Tb1Lu) cells, and 81 x 10(6) SV-40 virus-transformed embryonic diploid human lung (WI-38VA13A) cells were obtained in 6-14 days from dilute inocula in T-60 or T-75 flasks; these were equivalent to about 4, 3, 3, 4, 2, 4, and eight monolayers, respectively. Perfusion of an NF-ER culture for 6 wk with medium plus 10% whole calf serum yielded a cell density equivalent to 12 monolayers (140 x 10(6) cells per T-75 flask). This culture exhibited random labeling of nuclei from bottom to top after pulsing for 90 min with thymidine-(3)H. Medium plus 0.1% serum maintained NF-JAM cultures at constant viable cell numbers with virtual absence of thymidine-(3)H labeling. Similar results were obtained with WI-38 cultures, but WI-38VA13A cells continued active DNA synthesis and mitosis in medium with 0.1% serum to form 16-20 layers of cells (191-239 x 10(6) cells per T-75 flask) in 27 days. WI-38VA13A cells ceased proliferation and became nonviable rapidly in serumless medium.


Inorganic pyrophosphatase of rat liver mitochondria. Correlation of latency with catalytic properties and intramitochondrial location. Stimulation of Mg(2+)-dependent inorganic pyrophosphatase activity several fold by disruption of mitochondrial membranes does not appreciably alter the catalytic properties of the enzyme. Stimulation is due to increased accessibility of substrate to the enzyme, which is not solublized on activation. The enzyme is attached to the inside of the inner membrane, and under physiological conditions probably hydrolyzes only intramitochondrially-produced PP(i).


Enzyme cytochemistry of gastric parietal cells at a fine structure level. Cytochemical separation of the endoplasmic reticulum from the "tubulovesicles".


Amoebic meningo-encephalitis.

Amoebic meningo-encephalitis.


Nuclear magnetic resonance study of the interaction between acetylcholine and horse serum cholinesterase.


Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes. The changes occurring in rat hepatocytes during a 5 day period of treatment with phenobarbital were determined by morphometric and biochemical methods, particular attention being paid to the endoplasmic reticulum. The hepatocytic cytoplasm played an overwhelming part in the liver hypertrophy, while the hepatocytic nuclei contributed to only a moderate extent. The endoplasmic reticulum accounted for more than half of the increase in cytoplasmic volume. The increase in the volume and number of hepatocytic nuclei in the course of phenobarbital treatment was associated with changes in the ploidy pattern. Until the 2nd day of treatment both the rough-surfaced endoplasmic reticulum (RER) and the smooth-surfaced endoplasmic reticulum (SER) participated in the increase in volume and surface of the whole endoplasmic reticulum (ER). Subsequently, the values for RER fell again to control levels, whereas those for SER continued to increase, with the result that by the 5th day of treatment the SER constituted the dominant cytoplasmic element. The specific volume of mitochondria and microbodies (peroxisomes) remained constant throughout the duration of the experiment, while that of the dense bodies increased. The specific number of mitochondria and microbodies displayed a significant increase, associated with a decrease in their mean volume. The phenobarbital-induced increase in the phospholipid and cytochrome P-450 content of the microsomes, as well as in the activities of microsomal reduced nicotinamide-adenine dinucleotide phosphate-cytochrome c reductase and N-demethylase, was correlated with the morphometric data on the endoplasmic reticulum.


A mechanism for the action of penicillamine in the treatment of Wilson's disease.


Effect of pyrophosphate on hydroxyapatite and its implications in calcium homeostasis.


The pyridine nucleotide cycle.

The pyridine nucleotide cycle.


Estimation of angiotensin in blood by the preparation of isotopic derivatives.


Renin and euryhalinity in the Japanese eel, Anguilla japonica.


Aldolase C in brain tumour.

Aldolase C in brain tumour.


Increased yields of stomatitis virus from hamster cells injected with mycoplasma.


Tumors of the jaws in Korea. Report of 157 cases.


Improved graft survival after treatment with Bordetella and anti-lymphocyte serum.


Different cell culture characteristics of two strains of murine sarcoma virus.


Localization of the cardiac sympathetic synapses in the dog.


Dissociation of multiple polyoma virus functions by ultraviolet irradiation.


Effect of inhibitors of protein synthesis on renal pressor factors.


Effect of angiotensin on the denervated kidney in the dog.


Inhibition of human cytomegalovirus in vitro by double-stranded polyribocytidylic-inosinic acid (poly Ir.Cr).


1-methyl-1-nitrosourea depression of brain nicotinamide adenine dinucleotide in the production of neurologic toxicity.


Plaque assay of Herpesvirus hominis on human embryonic fibroblasts.


The prevention of acute renal failure in the rat by long-term saline loading: a possible role of the renin-angiotensin axis.


Interferon and resistance to upper respiratory virus illness.


A comparison of immune cytolysis and virus-induced fusion of sensitive and resistant cell types.


Structural and functional properties of Escherichia coli DNA polymerase.


Enzymes involved in the early stages of repair of ultraviolet-irradiated DNA.


Joining of DNA strands by DNA ligase of E. coli.


DNA replication in vitro. I. Synthesis of single-stranded phi X174 DNA in crude lysates of phi X-infected E. coli.


On the mechanism of the polynucleotide joining reaction.


The state of the DNA of polyoma virus and SV40 in transformed cells.


Cardiac output and postganglionic sympathetic activity during acute respiratory alkalosis.


The effects of nondepolarizing relaxants and anticholinesterases on the neuromuscular refractory period of anesthetized man.


Prenarcotic doses of barbiturates as an aid in localizing diseased brain tissue.


Malic dehydrogenase isoenzymes in green stem tissue of Opuntia: isolation and characterization.


Properties of an adenyl cyclase partially purified from frog erythrocytes.


Cytochrome oxidase solubilization at high pH. II. Separation and partial isolation of cytochrome oxidase from beef heart mitochondria without use of detergents or sonic oscillations.


[Cytochrome oxidase solubilization at high pH. I. Effects of pH, Ca2+ and Mg2+ on the reversible solubilization of cytochrome oxidase and cytochrome b by synthetic zeolites and by EDTA].


Restoration of gluconeogenesis in biotin-deficient rats.


On the mycobactericidal effect of the interaction isoniazid--copper.


Phosphatidylinositol kinase in rat kidney cortex. II. Subcellular distribution and kinetic properties.


Growth characteristics of rhinoviruses in human gingival cells.


Simultaneous rise in complement-fixing antibodies against herpesvirus hominis and varicella-zostervirus in patients with chickenpox and shingles.


Basal urinary pyrophosphate excretion in pseudogout.


Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli.


The action of crystalline lactate dehydrogenase from rabbit muscle on glyoxylate.


Establishment, steady state and cure of a chronic infection of LLC cells with West Nile virus.


The incorporation of [2-14C]glycine and delta-amino[4-14C]-laevulinic acid into the prosthetic groups of cytochrome oxidase and other cytochromes in yeast adapting to oxygen.


Mechanism of puromycin activation of tadpole liver glycogen synthetase.


Nucleotide inhibition of adenyl cyclase activity in fat cell membranes.


The effect of gonadotropins on testicular adenyl cyclase.


The photocatalytic action of adsorbed riboflavin.


On the deposition and utilization of inorganic pyrophosphate in Tetrahymena pyriformis.


Carbenoid intermediates from the photolysis of haloalkylcobalamins.


Electron paramagnetic resonance spectra of some vitamin B 12 derivatives.


Survey of pyridine nucleotide metabolism in Tetrahymena pyriformis.


Nicotinamide-adenine dinucleotide photoreduction in Rhodospirillum rubrum chromatophores.


Reactivity of Anacystis nidulans cytochrome c-554 with cytochrome oxidases.


Effect of anions on oxidative phosphorylation in submitochondrial particles.


Distribution of alpha-tocopherol in beef heart mitochondria.


The effect of glucose on the electron-transport systems of the aerobic bacteria Azotobactervinelandii and acetobacter suboxydans.


Liver transplantation in man--3, Studies of liver function, histology, and immunosuppressive therapy. The experience gained from 13 hepatic transplant operations is described, with particular reference to the findings in nine patients who survived the immediate operative period. A major problem was found to be infection. Fulminant pneumonia caused death in two adults, at a time when liver function was virtually normal. Infection related to bile fistula and sepsis may be overcome by an improved method of biliary drainage by cholecyst-dochostomy, which was carried out in the last two patients. Jaundice in the second week due to rejection was observed in several patients. The striking histological change was centrilobular cholestasis. The jaundice, which was not prevented by administration of antilymphocyte globulin, was rapidly controlled by temporarily increasing die dose of prednisone. One patient who survived for four and a half months and who had a poor tissue match subsequently developed chronic rejection with progressive cholestatic jaundice. Five of the patients were able to go home and at time of publication two are alive and well 14 and 20 weeks after treatment.


The quantitative determination of bile salts in bile using thin-layer chromatography and 3 alpha-hydroxysteroid dehydrogenase.


The effect of vasoactive drugs on local coronary flow.


A simple rapid method for the determination of total nitrogen in urine.


Deficits in shock-avoidance performance after amygdala-hippocampus separation.


An electron microscopic study of target fibers, target-like fibers and related abnormalities in human muscle.


Comparison and analysis of the teratogenic effects of serotonin, angiotensin-II, and bradykinin in mice.


Studies on mechanism of action of salicylates. V. Effect of salicylic acid on enzymes involved in mucopolysaccharides synthesis.


Adenosine 3',5'-monophosphate-dependent protein kinase from brain.


Toxicity of parathion, systox, octamethyl pyrophosphoramide, and methyl parathion in man.


A study of the measurement of cholinesterase by constant-pH titration: the effect of hemolysins and a comparison with the electrometric technique.


A comparison of the pharmacology of the isolated rabbit ear and its central artery.


Changes of nuclear RNA in hepatomas as revealed by RNA-DNA hybridization.


The susceptibility of some Australian fauna to infection with foot and mouth disease virus.


ACTH and decubitus ulceration: an experimental study. 1. Ulcers due to neurectomy with excision of the sciatic nerve are more severe than those due to tenotomy and can be inhibited by a single dose of ACTH.2. Timing and mode of administration of ACTH to prevent decubitus ulceration is critical and depends on its ability to prevent the separation of endothelial cells.


Muscarinic component of splanchnic-adrenal transmission in the dog. 1. The effect of atropine on catecholamine release evoked by stimulation of the splanchnic nerve was studied in the adrenal medulla of the dog. The magnitude of the catecholamine release was estimated biologically on the basis of the pressor response occurring in the perfused and acutely sympathectomized hindquarters of the same dog by comparing it with responses elicited by intravenous injection of adrenaline.2. Atropine reduced the responses to nerve stimulation, and appeared to have a more prominent effect on the responses elicited by stimulation at moderate frequency (10 pulses/sec).3. Hexamethonium or nicotine caused a more powerful, but not complete, blockade of transmission; the subsequent injection of atropine caused a further inhibition of the residual responses, leading to a complete, or near complete, abolition of the release by nerve stimulation.4. The data were taken as evidence that transmission of impulses through muscarinic receptors occurs in normal conditions in the adrenal medulla of the dog, though this type of transmission is less prominent than that through nicotinic receptors.


The action of general anaesthetic agents on root responses of the frog isolated spinal cord. 1. The action of volatile and barbiturate general anaesthetic agents on synaptic transmission in the frog isolated spinal cord has been studied by recording ventral root synaptic potentials and spike discharges evoked by volleys in a dorsal root and in the lateral column fibres.2. Some observations on the distribution of the lateral column fibres and the characteristics of the dorsal root potentials have been presented.3. Volatile agents depressed and eventually abolished all components of the ventral root responses. Failure of motoneurone discharge was the result of two factors, a decrease in the slope of the synaptic potential and an elevation of the critical depolarization required to trigger propagated impulses.4. Barbiturate compounds, in contrast, readily abolished polysynaptic components of the ventral root responses, but the short latency discharge produced by lateral column stimulation was potentiated, and was accompanied by a lowering of the firing threshold of motoneurones. The mechanism of this potentiation by barbiturate compounds is discussed.5. It is concluded that volatile agents act predominantly on the initial segment and subsynaptic elements of the motoneurone, whereas barbiturate compounds depress the presynaptic or postsynaptic components of interneuronal synapses.


Benzoyl esterases of fungi.

Benzoyl esterases of fungi.


Estrogen conjugates of hen's urine.

Estrogen conjugates of hen's urine.


The effect of metals on the S-S polypeptide receptor in depolarized rat uterus. 1. Metals potentiate the contractile effects of S-S polypeptides in depolarized rat uterus. Their order of potency is Co(++)>/=Co(+++)>/=Mn(++)>/=Ni(++)>/= Mn(+++)>Zn(++)>/=Mg(++)>Fe(++)>Fe(+++)>/= Ca(++)>Be(++)=Sr(++)=Ba(++)=Cu(++)=O.2. S-S polypeptides with relatively weak oxytocic activity such as lys-vasopressin, arg-vasopressin and orn-vasopressin are strongly potentiated by metals while highly active polypeptides such as oxytocin are weakly potentiated.3. Potentiation by metals was specific for S-S polypeptides; other polypeptides (bradykinin, hypertensin) as well as acetylcholine and isoprenaline were unaffected.4. Potentiation by metals occurs rapidly and is fully reversible. In all cases some activity was retained by S-S polypeptides even in the complete absence of metals.5. A scheme which could account for the observed effects has been formulated. This assumes the formation of a ternary complex between receptor, metal and polypeptide leading to improved alignment between polypeptide and receptor.6. Analogies are discussed between metal enzymes and the S-S polypeptide receptor for which the term metal receptor is proposed.


Manganese in the fresh water clam.

Manganese in the fresh water clam.


Noradrenergic rather than serotonergic basis of reward in the dorsal tegmentum.


Collagenase production by human dermis in vitro.


Lateral inhibition in a motor output system. I. Reciprocal inhibition in Dipteran flight motor system.


Lateral inhibition in a motor output system. II. Diverse forms of patterning.


Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording.


Discharge patterns of brain-stem respiratory neurons during Hering-Breuer reflex evoked by lung inflation.


Some possible neural correlates of combination tones.


Time course of minimal corticomotoneuronal excitatory postsynaptic potentials in lumbar motoneurons of the monkey.


Block of arachnoid villus by subarachnoid hemorrhage.


Inhibition of norepinephrine uptake in hearts by angiotensin II and analogs.


Selective augmentation of the pressor responses to catecholamines by metanephrine.


Influence of d-tubocurarine, decamethonium and succinylcholine on repetitively evoked end-plate potentials.


Antimicrobial prophylaxis.

Antimicrobial prophylaxis.


Effects of alpha,alpha'-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl bromide (DMAE) on neuromuscular transmission.


Function of the pancreatic B-cells in hamsters bearing a transplantable islet cell tumor.


Concentration of the virus of foot and mouth disease by foam flotation.


Fundamentals of mammographic diagnoses of benign and malignant diseases.


The absence of "heme-heme" interactions in hemoglobin.


Tumor-specific antigens detected by inhibition of macrophage migration. Tumor-specific antigens of a guinea pig hepatoma induced by diethylnitrosamine were detected by the inhibition of migration of specifically sensitized macrophages from capillary tubes, and by the local passive transfer of delayed skin hypersensitivity and the suppression of growth of intradermally same injected tumor.


Virus-like antigen, antibody, and antigen-antibody complexes in hepatitis measured by complement fixation. Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis. Antigen was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained. Antibodies arising during hepatitis are usually combined with antigen and cause anticomplementary activity in the serum, which is reversible with excess antigen or antibody. Tests for antigen and specific anticomplementary activity can be used diagnostically and to screen blood donors for hepatitis carriers.


Radiation leukemia virus: quantitative tissue culture assay. Radiation leukemia virus does not propagate in tissue cultures from either Swiss or C57BL mouse embryos, but it does augment focus formation by the defective Moloney leukemia pseudotype of murine sarcoma virus in Swiss mouse cells and thus can be quantitatively assayed.


Function of sympathetic nerves in blood vessels.


Tumors of the new born.

Tumors of the new born.


Importance of minor salivary gland tumors for the general practitioner.


Chylous ascites. Management with medium-chain triglycerides and exacerbation by lymphangiography.


Granular cell myoblastoma of the common bile duct.


Angiography of the gastrointestinal tract: results and experience.


Uterosalpingography.

Uterosalpingography.


Mixed mesodermal tumors.

Mixed mesodermal tumors.


Herpes simplex. Clinical aspects and electron microscopic findings.


Non-fatal Clostridium perfringens bacteremia.


Chromatography of cyclic 3'5'-adenosine monophosphate on silica gel glass microfiber sheets.


2-(alkyl- and arylamino)-5-nitrothiazole derivatives with antiamebic, antitrichomonal, and antimalarial properties.


Studies on adrenal cortical function in patients with lung cancer.


Secretin-like choleresis produced by a diarrheogenic non-beta islet cell tumor of the pancreas.


Immunologic and virus studies with human sarcomas.


Renal cortical tumors: a 40-year statistical study.


Aspiration biopsy of salivary gland tumors. IV. Morphologic studies on smears and histologic sections from 45 cases of adenoid cystic carcinoma.


Effect of raphanin on the multiplication of some RNA and DNA viruses in, and interferon production by, cultured cells.


Primary hepatoma in Uganda. A prospective clinical and epidemiologic study of forty-six patients.


Tetraphenylborate stimulation of phospholipid labeling in goldfish brain.


Solubilization of a neutral phenazyl free radical by DNA.


Electron paramagnetic resonance of nitric oxide cytochrome C.


Action of 3',5'-cyclic adenosinemonophosphate on the protein synthesizing capacity of thyroid polyribosomes in vitro.


Rapidly oxidizable equivalents in the terminal portion of the respiratory chain of uncoupled rat liver mitochondria.


Adenyl cyclase in human platelets: activity and responsiveness. A clinical study was conducted whereby the activity of adenyl cyclase in the human platelet was demonstrated.  The study showed that this activity can be stimulated and inhibited in vitro.  Platelets were isolated from normal donors.  The laboratory procedures involved in the study are described in detail.  It seems that many of the biologic processes which occur in the human platelet are dependent on the breakdown of ATP (adenosine-tri-phosphate) to, among other substances, AMP (adenosine-3',5' monophosphate).  Activity of the adenyl cyclase was stimulated by fluoride, prostaglandin E1, and glucagon; it was inhibited by thrombin, epinephrine, norepinephrine, and serotonin.  PG (prostaglandin) E1 at concentrations of 20 ng/ml and above increased adenyl cyclase in 7 experiments by 3-5 times.  Even at concentrations as low as 2 ng/ml., PGE2 caused perceptable stimulation.  The PGE, while stimulating adenyl cyclase activity, also inhibited aggregation of platelets by a variety of substances.  Results of the study suggest that adenosine-3',5' monophosphate may be important in the regulation of platelet adhesiveness.


Assignment of tryptophan indole NH proton resonances of lysozyme.


The enzymic degradation of 3',5' cyclic AMP in strains of E. Coli sensitive and resistant to catobolite repression.


Effects of deoxyfrenolicin on isolated adipose cells. I. Glucose and fructose utilization.


Comparison of assay methods for studying O,O-diethyl, O-p-nitrophenyl phosphate (paraoxon) detoxication in vitro.


Studies with tryptophan metabolites in vitro. 3. The effect of schistosomicidal drugs on kynureninase and kynurenine transaminase of normal mouse liver.


Hormone-secreting tumours of the pancreas.


Inhibiting effect of angiotensin on potassium accumulation of adrenal cortex.


The bursa of fabricius and adrenal cortical activity of Gallus domesticus.


Biosynthesis of lipids in subcellular fractions of frog liver.


A relationship between ionic environment and hormonal activation of phosphorylase in an insect.


Hypnic physiological myoclonias in man: an EEG-EMG study in normals and neurological patients.


A segmental neurocutaneous manifestation. Report of a case of nevus unius lateralis and unilateral hypotrophy.


Selective inhibition of bacterial enzymes by free fatty acids. Octanoic acid inhibits, in vitro, the bacterial enzymes glucose-6-phosphate dehydrogenase, phosphofructokinase, pyruvate kinase, fumarase, lactate dehydrogenase, and the malic enzyme of Arthrobacter crystallopoietes. The free fatty acid appears to act as an inhibitor of lipogenesis, although it does not affect the rate of gluconeogenesis. To demonstrate that this inhibition may be of physiological significance in vivo, those enzymes not involved in lipogenesis, such as fructose-1, 6-diphosphatase, phosphoglucomutase, phosphohexoisomerase, aconitase, nicotinamide adenine dinucleotide phosphate (NADP) isocitrate dehydrogenase, NADP glutamate dehydrogenase, malate dehydrogenase, and isocitrate lyase, were assayed and found not to be inhibited by the free fatty acid.


A potentiating-factor-dependent neutralizing antibody in calves and rabbits against bovine parainfluenza 3 virus.


Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis). Report of a case incorporating both purely degenerative and intense inflammatory changes, with special prominence of the latter in the putamen.


Gram-negative rod bacteremia.

Gram-negative rod bacteremia.


Recent microbiological studies with gentamicin.


Use of gentamicin in combinations with other antibiotics.


Experiences with the new antibiotic gentamicin.


Nephrotoxicity of aminoglycosides and gentamicin.


Sensitivity tests of klebsiella, enterobacter, and serratia.


Viruses and embryos.

Viruses and embryos.


Central synaptic transmission--microelectrophoretic studies.


Pharmacology of motor nerve terminals.

Pharmacology of motor nerve terminals.


In vivo therapy of oncogenic viruses.

In vivo therapy of oncogenic viruses.


Peripheral and central phenomena of post-epileptic extinction.


Experimental lead neuropathy: a disease of the supporting cells in the peripheral nervous system.


Glioblastoma multiforme.

Glioblastoma multiforme.


Virilizing tumors of the adrenal gland in childhood: report of eight cases.


Requirement of a stable secondary structure for the antiviral activity of polynucleotides.


Stimulation of DNA synthesis in resting stage human fibroblasts after infection with Rous sarcoma virus.


Adenoviruses.

Adenoviruses.


In vitro production of angiotensin I by renal glomeruli.


Further electron microscopic studies of E. histolytica.


Cytochemical observations on Plasmodium berghei and P. gallinaceum.


Solid-phase peptide synthesis.

Solid-phase peptide synthesis.


Neurosecretion.

Neurosecretion.


Factors affecting recombination of lactate dehydrogenase isoenzyme subunits.


Enzymatic phosphorylation of D-sedoheptulose with animal liver.


An E.S.R. study of an X-irradiated single crystal of 5-iododeoxyuridine.


The chemotherapy of enterobacterial infections.


E.S.R. study of x-irradiated single crystals of 5-bromodeoxyuridine and 5-iododeoxyuridine.


Hemoproteins in anaerobically grown yeast cells.


Plasma corticotrophin levels in primary and secondary adrenocortical insufficiency.


Influence of HCG on the production of oestrogens by the adrenal gland.


Dissociation between production and storage of corticotrophin-releasing factor.


Cyclic 3',5'-AMP and ovarian ascorbate depletion.


Effect of bromide on evoked release of monoamines from brain slices and intact atria.


Removal of angiotensin by isolated perfused organs of the rat.


Metabolism of the angiotensins in isolated perfused tissues.


Angiotensin accelerates catecholamine biosynthesis in sympathetically innervated tissues.


Electron spin resonance in biological tissues.


Temperature and saturation effects in the ESR spectra of whole tissues.


Pharmacological aspects of the coronary circulation.


Acetylcholine facilitation, atropine block of synaptic excitation of cortical neurons. Sinigle neurons in cat visual cortex were driven by afferent stimuli to determine the effects of drugs liberated from multibarreled micropipettes on synaptic transmission. Acetylcholine increased, and atropine decreased, the number of neuron discharges fired in response to stimulation of the mesencephalic reticular formation without necessarily affecting responses to other stimuli or affecting spontaneous firing.


25-hydroxycholecalciferol: direct effect on calcium transport. The perfused small intestine from a vitamin D deficient rat exhibits about one-half the calcium transport of the intestine from a rat given vitamin D. These levels of calcium transport can be maintained for at least 4 hours. Addition of 2.5 micrograms of 25-hydroxycholecalciferol added to the vitamin D deficient intestine via the arterial blood perfusate induces a rise in calcium transport to +D levels within 2 hours. In contrast, 250 micrograms of vitamin D(3) given in the same manner has no effect on the calcium transport level overa 4-hour period. These data provide strong evidence that 25-hydroxycholecalci ferol represents the metabolically active form of vitamin D(3).


Islet cell tumors of the pancreas.

Islet cell tumors of the pancreas.


The mechanism of action of some antibacterial agents.


Clinicopathological conference...cirrhosis and bloody ascites.


Ultrastructure of multiple pancreatic tumors in a case of Zollinger-Ellison syndrome.


Initial high dose irradiation for metastases causing spinal cord compression in children.


Appearance of the transverse sinuses by brain scanning.


Jugular venography.

Jugular venography.


Consumption coagulopathy and acute renal failure due to gram-negative septicemia after abortion. Complete recovery with heparin therapy.


The period and nature of hazard in clinical renal transplantation. II. The hazard to transplant kidney function.


The period and nature of hazard in clinical renal transplantation. I. The hazard to patient survival.


Recording of nerve potential.

Recording of nerve potential.


The activity of oxidative enzymes in short-term explant cultures of gliomas in vitro. I. Coenzyme I-bound dehydrogenases and succinate dehydrogenase.


Erythrocyte membrane of Anadara inflata, a marine bivalve mollusc.


Laboratory aids in the diagnosis of endocrine disorders.


Cytogenetics and abortion.

Cytogenetics and abortion.


Genetic factors in carcinoma.

Genetic factors in carcinoma.


Influence of germ-free status on hepatoma induction by 7,12-dimethylbenz(a)anthracene in C3H mice.


Electron microscopy of intranuclear inclusions in a mixed tumor.


Malignant transformation of hamster cells by cell-free extracts of bovine papillomas (in vitro).


Skin temperature of the rabbit ear during degeneration of its sympathetic nerve supply.


The formation by the rabbit of N-acetylglucosaminides of steroid phenolic sulfates.


Metabolism of 17-alpha-ethynylestradiol and its 3-methyl ether by the rabbit; an in vivo D-homoannulation.


Effect of glucagon on rat heart adenyl cyclase.


Study on the stability of lysosome membranes. IV. Protection of liver lysosomes from the labilizing effect of chlorpromazine with succinate and glutamate in vivo.


Hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with cortisol. 1. Cortisol, administered subcutaneously every day for long periods, caused growth retardation, adrenal atrophy and impaired hypothalamo-pituitary-adrenal (HPA) function in the rat.2. The growth rate and the functional activity of the HPA system gradually returned to normal after steroid withdrawal.3. Normal adrenal sensitivity to corticotrophin returned more rapidly than normal pituitary corticotrophic function, suggesting that the initial impairment of HPA function was due both to reduced responsiveness of the adrenal gland to corticotrophin and failure of the pituitary gland to secrete the hormone.


Pagetoid spread of bronchogenic carcinoma.


Debridement of dermal ulcers and decubiti with collagenase.


A note on an embryonal nephroma met with in a fowl.


Changed environmental conditions affecting normal body temperature of mice and its effect on the multiplication of foot and mouth disease virus.


Metabolic action of palmitoylcarnitine on rat liver mitochondria.


The structure, stereochemistry and reactions of the guanidine moiety of viomycin.


Transformation of chick fibroblast cultures with avian myeloblastosis virus.


The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders. II. Temporal changes in the distribution of urinary tritiated metabolites in affective disorders.


A method for microscopy of the mammary gland in the living mouse.


The assay of ACTH and the action of ACTH and steroids on corticosteroidogenesis in the mouse.


Teratogenic effects of carotid ligation on the developing dentition of the Rhesus monkey.


Adrenergic neuron blockers and transmitter release after sympathetic denervation studied in the conscious rat.


Amoebic dysentery precipitated by corticosteroids.


Mental nerve palsy in malignant lymphoma.


Medullary cancer of the thyroid gland associated with hypercorticism.


Hypoglycemia associated with extrapancreatic tumors. An immunofluorescent study.


Mixed tumors of the parotid gland. An ultrastructural study.


Cancer of the nasopharynx. Factors influencing prognosis.


Measurement of renin activity in plasma by a radioimmunoassay for angiotensin I.


Congenital malformation of the central nervous system associated with genital type (type 2) herpesvirus.


Long-term anticoagulant prophylaxis after myocardial infarction.


Immunization with inactivated poliovirus vaccine and attenuated type 3 poliovirus. I. Vaccination with the WM3 strain in 20 families.


Hypertension with inappropriate aldosterone stimulation.


Pediatric arteriography in abdominal and extremity lesions. Clinical experience, indications, and technic.


A hereditary neurological disease with facial spasm.


Properties of the trypsinised red cell receptor reacting in reversible agglutination by normal sera.


Pituitary control of erythropoiesis.

Pituitary control of erythropoiesis.


Accommodation of monosynaptic transmission in spinal motoneurone.


Some principles of surgical and prosthodontic treatment of patients with malignant tumours of the maxilla.


Shunt flow in glioblastoma. Study in regional autoregulation.


Multiple primary carcinomata of the colon.


Mechanism of hormone action. Role of nucleotides in gluconeogenesis.


Insulin antibodies.

Insulin antibodies.


Criteria for distinguishing normal from subnormal adrenocortical function using the Synacthen test.


Virus infections in patients with malignant disease.


Quantitative determination of formaldehyde liberated with periodate oxidation.


Recent developments in the identification of human skeletal material.


Cytomegalovirus mononucleosis in previously healthy individuals. Five new cases and follow-up of 13 previously published cases.


Evidence for glycolysis in bovine retinal microsomes and photoreceptor outer segments.


Transport phenomena associated with the deposition and disappearance of pyrophosphate granules in Tetrahymena pyriformis.


Chromosomal aberrations in two cases of inherited aplastic anemia with unusual clinical features.


The biosynthesis and degradation of nicotinamide-adenine dinucleotide during cick embryonic development.


Electron spin resonance studies of ribonucleotide reduction catalyzed by the ribonucleotide eductase of Lactobacillus leichmannii.


Localization of factor VII (proconvertin) in a microsomal subfraction.


Dietary regulationof glycolytic enzymes. 3. Adaptive changes in rat jejunal pyruvate kinase, phosphofructokinase, fructosediphosphatase and glycerol-3-phosphate dehydrogenase.


Regulation of the synthesis of 5-phosphoribosyl-I-pyrophosphate in intact red blood cells and in cell-free preparations.


Effects of fasting, diabetes and glucocorticoids on gluconeogenic enzymes in the sheep.


Foot drop.

Foot drop.


Surgical treatment of primary liver cancer.


Micropuncture study of the action of angiotensin-II on tubular sodium and water reabsorption in the rat.


The effect of an expansion of extracellular fluids on net Na flux in the jejunum of rats. An experimental model for the study of the third factor.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 31-1969.


Estrogen replacement therapy.

Estrogen replacement therapy.


Ultrastructural localization of metabolic enzymes during the human endometrial cycle.


Evaluation of the role of the feedback effect of corticosteroids in the control of pituitary ACTH release.


Effect of angiotensin superfusion on the rate of aldosterone production by incubated rat adrenals.


Isolation of rough and smooth microsomes from rat liver by means of a commerically available centrifuge.


Fluorometric micro determination of citrate in tissue extracts.


Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme.


Adenyl cyclase assay in fat cell ghosts.


Use of polyethyleneimine-cellulose thin layers in assay of pyrophosphate-ATP exchange reactions.


Coagenase in corneal ulcerations.

Coagenase in corneal ulcerations.


Prevention of the ulcers of the alkali-burned cornea. Preliminary studies with collagenase inhibitors.


Epidemiology of major respiratory diseases of the horse.


A selective inactivation of dimethylallyl-transfering activity of prenyltransferase.


A new pyruvate kinase isozyme in hepatomas.


Flocculating antigen in the sera of haemorrhagic smallpox cases.


Metabolic and electrophoretic studies of rat liver sorbitol dehydrogenase.


Tumors of the parapharyngeal space.

Tumors of the parapharyngeal space.


ADP-dependent palmitoylcarnitine sensitivity of mitochondria isolated from the perfused rabbit heart.


Changes in the short wavelength absorption spectrum of tyrosine as a result of its participation in peptide, or similar bonds.


Biochemical studies on lipopolysaccharides of Salmonella R mutants. 6. Investigations on the structure of the lipid A component.


NAD nucleosidase activity in rabbit reticulocytes and erythrocytes.


Antibodies against degradation products of polysaccharide antigens.


Effect of tolbutamide on the lipolytic response of adipose tissue to adrenaline and ACTH.


Mechanism of ovarian cholesterol mobilization by luteinizing hormone.


Intranuclear and intranucleolar tubular structures in Novikoff hepatoma cells.


Histochemical localization of some enzymes in the ampullae of the bull ductus deferens.


Hemodynamic spectrum of vasopressor and vasodilator drugs.


Electrical transmission mediated by an identified cholinergic neuron of Aplysia.


Recombination and segregation in somatic cell hybrids.


Angiotensin teratogenicity in the fetal hamster.


Aphasia and rapid eye movement sleep.

Aphasia and rapid eye movement sleep.


Signal transmission along retinal rods and the origin of the electroretinographic a-wave.


Attenuation of rhinovirus type 15 for humans.


Protection against poxviruses.

Protection against poxviruses.


Alpha-methyl-1-adamantane-methylamine hydrochloride: inhibition of Rous and Esh sarcoma viruses in cell culture.


Influence of synthetic (poly I:C) and viral double-stranded ribonucleic acids on adenovirus 12 oncogenesis in hamsters.


A study correlating virus particle frequency with disease progession in a transmitted murine leukemia.


Biological characteristics and viral spectrum of serially cultivated fetal rhesus monkey kidney cells.


Passive hemagglutination enhancement by periodate, low pH, and freeze-thaw treatment of aldehyde processed cells.


The hydrolytic activity in normal human and malignant tissue.


Isolation and growth of rat cytomegalovirus in vitro.


Cyclic adenylate and hypothalamic regulatory functions.


Refractoriness of KB cell cultures carrying Japanese B encephalitis virus to encephalomyocarditis virus infection.


Hypoproteinemia in mice after treatment with histamine-sensitizing factor from Bordetella pertussis.


Exercise, stress, and blood clotting in men.


Hypothalamicohypophyseal portal system in experimental ovarian tumorigenesis.


Natural and melatonin-induced sleep in young chickens--a behavioral and electrographic study.


Growth and sporulation of Clostridium welchii in breast and leg muscle of poultry.


Effect of antineoplastic agents on microsomal enzymes.


Comparative study of experimental herpes simplex encephalitis, rabies and Japanese encephalitis demonostrated by fluorescent antibody method.


Acute focal inclusion encephalitis a clinical pathological entity heretofore unrecognized in Israel (a study of 10 cases).


Herpes simplex encephalitis.

Herpes simplex encephalitis.


Perinatal cytomegalic inclusion encephalitis.


An autopsy case of acute hemorrhagic necrotizing encephalitis diagnosed as Japanese encephalitis by means of fluorescent antibody technique.


Cerebral lesions in generalized salivary gland virus infection (cytomegalic inclusion disease).


Somato-sensory evoked cortical potentials in subjects with peripheral nervous lesions.


The electromyogram in the evaluation of nerve injuries occurring in hospitalized patients.


Arteriography in children with abdominal mass.


Effect of the median eminence of the pigeon (Columba livia domestica L.) on the regulation of adenohypophysial corticotropin secretion.


Pituitary adrenocorticotrophic hormone (ACTH) induced hypoglycaemia.


A neuropharmacological analysis of hypothalamic and extrahypothalamic mechanisms concerned with the regulation of food and water intake.


Chemical mechanisms in the hypothalamus mediating eating and drinking in the monkey.


Physical studies of phospholipids. XI. Ca2+ binding to monolayers of phosphatidylserine and phosphatidylinositol.


Inductive transformation as a basic phenomenon in the genesis of cells of the zona fasciculata and reticularis of the adrenal cortex.


The use of cytostatic drugs in the treatment of trophoblastic neoplasia.


Blood pressure responses to angiotensin II following aldosterone and adrenalectomy.


Transmission between adrenergic nerves and smooth muscle in the course of Wallerian degeneration.


6. The fine structure of human photoreceptor synapses.


Histochemical and morphologic changes in gastric mucosa of dogs on ulcerogenic regimen.


Induction in hamsters of various carcinomas and sarcomas by in-vitro SV40-transformed homologous embryonic skin and subcutaneous tissue cells. Role of target cells in determining tumor morphology.


Sucrose interference in the assay of enzymes and protein.


Method for creating rapid cellular temperature perturbation.


Determination of coenzyme A and acetyl CoA in tissue extracts.


Carboxyl-terminal sequence of the glycine-arginine-rich histone from bovine lymphosarcoma, Novikoff hepatoma and fetal calf thymus.


Neurological disease after partial gastrectomy. Clinical and laboratory signs of neurological disease were found in 14 patients many years after partial gastrectomy. Vitamin B(12) deficiency occurred in most patients, but only those three who had signs of subacute combined degeneration of the cord and no osteomalacia responded well to treatment.


Studies on lymphocytosis induced by Hemophilus pertussis. I. Observations of cell counts in media after incubation of thymus cells and lymph node cells.


Studies on lymphocytosis induced by Hemophilus pertussis. II. Hematological-histochemical observations in experimental animals.


Studies on lymphocytosis induced by Hemophilus pertussis. 3. Clinical studies: observations of peripheral blood and cultured lymphocytes in vitro.


Purification and properties of the L-cysteinyl ribonucleic acid synthetase of bakers' yeast.


Standard Gibbs free energy, enthalpy, and entropy changes as a function of pH and pMg for several reactions involving adenosine phosphates.


An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli.


Nicotinic and muscarinic receptors in the cardiac sympathetic ganglia of the dog.


Effects of nicotine, dimethylphenylpiperazinium and cholinergic blocking agents at adrenergic nerve endings of the rabbit pulmonary artery.


Effects of environmental lighting and chronic denervation on the activation of adenyl cyclase of rat pineal gland by norepinephrine and sodium fluoride.


Effect of alpha-methyl dopa on the reserpine-induced suppression of motor activity and the conditioned avoidance response.


Studies on the morphogenesis of yeast mitochondria. 1. Development of mitochondrial functions during the growth phases of Saccharomyces cerevisiae.


Base sequences of small oligonucleotides. 1. Spectrophotometric determination of the structure of some adenine and guanine containing dinucleoside-monophosphates.


Plasma insulin studies in the diagnosis of insulinoma.


Histological study of the hypophysis of the transylvanian lamprey (Eudontomyzon danfordi Regan).


Sudden unexpected unexplained death in infants. A comparative clinicopathologic study.


Luteoma of pregnancy: steroidogenic and morphologic considerations.


Reoviruses isolated from turkeys with bluecomb.


Serologic study of a canine adenovirus (Toronto A26/61) infection in dogs.


Pathologic changes in placentas of ewes inoculated with bluetongue virus.


Diagnosis of bluetongue in cattle by intravascular inoculation of chicken embryos and immunofluorescence.


Mechanism of action of aldosterone.

Mechanism of action of aldosterone.


Inhibition by formaldehyde of energy transfer and related processes in rat liver mitochondria. II. Effects on energy-linked reactions in intact mitochondria and phosphorylating particles.


Partial purification and properties of ATP:GMP phosphransferase from rat liver.


RNA synthesis in exponentially growing rat hepatoma cells. I. A caution in equating pulse-labeled polyribosomal RNA with messenger RNA.


An improved, reproducible method opreparing rat liver plasma cell membranes in buffered isotonic sucrose.


Enzyme activities and ultrastructure of a membrane fraction from human erythrocytes.


Enzymatic distinction of rat intestinal cell brush border and endoplasmic reticular membranes.


Quantification of baroreceptor reflexes during anaesthesi in man.


Calcium binding properties of sarcoplasmic reticulum membranes.


Synthesis and turnover of membrane protein and lipid in Mycoplasma laidlawii.


Amoebic colitis exacerbated by steroids.


The phenomenon of differentiation in murine irus-induced leukemic cells.


Host resistance and the biological analysis of avian tumor virus infections.


Cholesterol esterase stimulation by luteinizing hormone in luteinized rat ovaries.


Cell-bound immune reactions against tumor specific transplantation antigens.


Cholesterol side-chain cleavage activity in the adrenal gland of the young rat: development and responsiveness to adrenocorticotropin hormone.


Inhibition by dexamethasone of the in vivo pituitary response to corticotropin-releasing factor (CRF).


Release of ACTH by substances of central nervous system origin.


Corticosteroid response to natural and synthetic corticotrophins in the autotransplanted sheep adrenal.


Subcellular localization of androgen in the rat ventral prostate in vivo.


Glycogen content in the rat testis from postnatal to adult ages.


Fractionation of nuclei from induced hepatomas by sucrose gradient centrifugation.


Reverisble inactivation of nicotinamide adenine dinucleotide kinase in extracts of unfertilized sea urchin eggs.


Miscellaneous viral vaccines.

Miscellaneous viral vaccines.


Hepatic abscess. An analysis of 86 cases.


On the homeostatic regulation of cortical activation during sleep.


The dream scene.

The dream scene.


A heat-stable nicotinamide adenine dinucleotidase from Pseudomonas fluorescens.


Inverse relationship of interferon production and virus content in cell lines from Burkitt's lymphoma and acute leukemias.


Terpene compounds as drugs. VI. Acyclic mono- and sesquiterpene thiocyanates and isothiocyanates.


Noncovalent binding of a spin-labeled inhibitor to ribonuclease. The stable free radical 2,2,6, 6-tetramethyl-4-hydroxypiperidin-1-oxyl monophosphate has been synthesized; it binds to ribonuclease. The selective changes in the nuclear magnetic resonance spectrum of the enzyme produced by the free radical make it possible to define qualitatively the region of the enzyme to which it binds. The radical appears to occupy a site similar to that to which inorganic phosphate binds which is close to or within the active site of the enzyme.


Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles. Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.


Egg production and disease: adenovirus.

Egg production and disease: adenovirus.


Hormonal regulation of nucleic acid and protein synthesis.


Induction of NAD-specific glutamate dehydrogenase in Neurospora crassa by addition of glutamate to the media.


Histochemical study of nephroblastoma.

Histochemical study of nephroblastoma.


Ribonucleic acid depolymerizing enzyme in Entamoeba histolytica.


Thron test in leprosy.

Thron test in leprosy.


Thyroid function in a family with the Pendred syndrome.


Plasma levels of testosterone in male rabbits following copulation.


Renin release from ischemic kidneys following angiotensin infusion in dogs.


The ultrastructural distribution of cytochrome oxidase activity in Plasmodium Berghei and P. Gallinaceum.


On the functional aspects of a preparation of an inner membrane fraction of liver mitochondria I.


Acute nonsuppurative meningoencephalitis associated with transient amaurosis.


Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies.


Influence of substrates on the dissociation of rabbit muscle D-glyceraldehyde 3-phosphate dehydrogenase.


Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. II. Proton relaxation rate and electron paramagnetic resonance studies of binary and ternary complexes.


Substrate binding specificity and properties of inosine monophosphate: pyrophosphate phosphoribosyltransferase (EC 2.4.2.8) from Brewers yeast.


Rat liver D-beta-hydroxybutyrate dehydrogenase. 3. Inhibition by topical anesthetics.


The synthesis of 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.


Comparison of haemodynamic effects of equipressor doses of intravenous angiotensin and noradrenaline in man.


Iatrogenesis in anesthesiology.

Iatrogenesis in anesthesiology.


An analysis of technetium (99mTcO4-) kinetics: the effect of perchlorate and iodide pretreatment.


Skeletal changes following irradiation of childhood tumors.


Overlap and the errors of plaque counting. I. The overlap biases of observed counts and their correction.


Empirical selection of antibiotics for hand infections.


Electron spin resonance signals in injured nerve. Under certain conditions nerves (such as the frog sciatic) exhibit electron spin resonance signals with several unusual properties: (i) variable g value and linewidth, (ii) anisotropic g tensor, and (iii) g value dependence on temperature. Such a signal must be due to a small ferromagnetic crystal formed when the nerve is subjected to pressure, such as that due to mechanical injury.


Effect of Sabin poliovirus vaccine on incidence of poliomyelitis in Italy.


Differential effects of scopolamine and chlorpromazine on REM and NREM sleep in normal male subjects.


Serum free fatty acids, growth hormone, and insulin during trials of ACTH and synthetic subunits.


The accumulation and elimination of crude and clarified poliovirus suxpensions by shellfish.


Acute respiratory illness in nursery school children: a longitudinal study of the occurrence of illness and respiratory viruses.


Rhinovirus infections of children in hospital; isolation of three possibly new rhinovirus serotypes.


Glomus tumor of the stomach. Report of a case and review of the literature.


Roentgen findings in extramedullary hematopoiesis.


Surgical resection of intrahepatic bile duct cancer.


Malignant abdominal neoplasms in childhood.


Insulin stimulatory tests in a patient with islet cell adenoma.


Ultrastructural injury of arterial endothelium. II. Effects of vasoactive amines.


Breast cancer in a man treated with diethylstilbestrol.


Pulmonary adenomatosis and peripheral adenocarcinoma of the lung. An ultrastructural demonstration of common morphologic features.


Ultrastructural injury of arterial endothelium. 3. Effects of enzymes and surfactants.


Poly-(L)-malic acid; a new protease inhibitor from Penicillium cyclopium.


Electron spin resonance of Cu(II) in copper-hemoglobin complexes.


Adenyl cyclase and hormone action. 3. Calcium requirement for ACTH stimulation of adenyl cyclase.


Demonstration of adenyl cyclase activity in canine cardiac sarcoplasmic reticulum.


Adenyl cyclase: relationship to stimulated DNA synthesis in parotid glands.


Comparative effects on RNA polymerase of the whole GAR histone and its peptides containing clusters of basic amino acids.


Animal cell cultures as a source of hormones.


The propagation and cytomorphological effects of bovine parainfluenza type 3 virus in organ cultures of bovine fetal tissues.


Effect of triton WR-1339 on rous virus-induced tumors in chickens.


An electron microscopic comparison of three strains of bovine parainfluenza-3 virus.


Low birthweight and postnatal physical development.


The "internal sphincter": is it under sympathetic control?


Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B.


Independence of the effects of epinephrine, glucagon, and adrenocorticotropin on glucose utilization from those on lipolysis in isolated rat adipose cells.


Tryptophan oxygenase of Pseudomonas acidovorans. Purification, composition, and subunit structure.


Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride.


Adenyl cyclase in fat cells. II. Hormone receptors.


Response of trypsin-treated brown and white fat cells to hormones. Preferential inhibition of insulin action.


Beta oxidation in glyoxysomes from castor bean endosperm.


Mammalian alpha-keto acid dehydrogenase complexes. V. Resolution and reconstitution studies of the pig heart pyruvate dehydrogenase complex.


Stimulation and suppression of aldosterone in plasma of normal man and in primary aldosteronism. The effect of stimulating and suppressive influences on plasma aldosterone in normal man and in patients with primary aldosteronism were studied using a sensitive double-isotope derivative assay for aldosterone. In normal sitting subjects, values were 9.2+/-0.9 (SE) mmug/100 ml and in subjects supine for 1 hr plasma aldosterone was 5.2+/-0.4 (SE) mmug/100 ml. Adrenocorticotropic hormone (ACTH), 0.5 U/hr, produced a rise of 46.8+/-22 (SE) mmug which was similar to the 1-hr effect of an infusion of a synthetic ACTH (beta(1-24), Cortrosyn). Angiotensin II in pressor amounts also increased plasma aldosterone 21.5+/-2.9 (SE) without change in plasma cortisol, whereas a subpressor dose ([unk]) had minimal effect.Fludrocortisone, 1.2 mg/day for 3 days, suppressed plasma aldosterone levels to 1.8+/-0.7 (SE) mmug/100 ml in five normal sitting subjects (P < 0.01); however, dexamethasone, 2 mg/day for 1-2 days, did not lower aldosterone concentration in plasma. In six patients with primary aldosteronism, plasma aldosterone on a normal sodium diet was 39.1+/-4.4 (SE) which differed significantly from normal sitting or supine subjects (P < 0.001). In contrast to the normal subjects, neither a pressor infusion of angiotensin II for 1 hr, nor fludrocortisone, 1.2 mg/day for 3 days, impressively altered plasma aldosterone levels. This approach appears to be useful for the study of the acute physiology and control mechanisms of aldosterone production in normal and hypertensive man.


The role of the liver in the metabolism of vitamin D. The metabolism of vitamin D(3) has been studied after intravenous injection of 10 IU of [1,2-(3)H]-vitamin D(3) to vitamin D-deficient rats. The disappearance of the radioactivity from the plasma follows a very peculiar pattern characterized by an early rapid disappearance followed by a rebound of radioactivity before assuming still a third rather slow disappearance rate. The "rebound" phenomenon is concomitant with a rapid release of the radioactivity from the liver and is accounted for by the appearance of 25-hydroxycholecalciferol and other metabolites in the blood. It is postulated that the liver is the major site of transformation of vitamin D(3) into 25-hydroxycholecalciferol.


Competitive binding of free and conjugated oestrogens to plasma proteins.


Afferent pathways of stressful stimuli: corticotropin release after partial deafferentation of the medial basal hypothalamus.


Bilateral testicular tumors in untreated congenital adrenocortical hyperplasia.


The renin-angiotensin system in a marsupial (Trichosurus vulpecula).


A serological survey in dogs for antibody to human respiratory viruses.


Mitochondrial cavitation and hypertrophy in rat adrenal cortex due to aminoglutethimide.


The renin-angiotensin system in curable hypertension.


Cell-mediated demyelination of peripheral nerve in tissue culture.


Paradoxical sleep.

Paradoxical sleep.


Breast cancer.

Breast cancer.


Urologic surgery.

Urologic surgery.


Neuroglia electrically coupled to neurons. Applied electric current is transmitted between mammalian glial cells grown in tissue culture. A similar electrical coupling exists between certain neurons as well as between neuroglia and neurons. Although this phenomenon may be a peculiarity of mammalian neural cells maintained in culture, it may, on the other hand, represent a phenomenon with greater neurophysiological significance, a process whereby neurons can become silent.


Histochemical properties of regenerating mucous membrane in the rat stomach.


Viomycin.

Viomycin.


Apert's anomaly--a transition.

Apert's anomaly--a transition.


Abortion complicated by Clostridium welchii infection and acute renal failure.


The occurrence of precipitating antibodies to bovine adenovirus in sera of farm animals and man in Iran.


Bronchiolo-alveolar cell carcinoma of the lung.


Effect of conjugated oestrogen upon gonadotrophin excretion patterns in fetile women.


Adrenocorticotrophic potency of long-acting corticotrophin preparations during long-term treatment of neurological patients.


Electrophysiological studies on peripheral nervous function in multiple sclerosis.


A comparison of two methods of determining DPNH-methemoglobin reductase.


Preparation and testing of duck embryo cell culture rubella vaccine.


Iodide goiter and the pharmacologic effects of excess iodide.


Zollinger-Ellison syndrome. Clinical and histopathologic manifestations.


Granular cell myoblastoma of larynx with papillary adenocarcinoma of thyroid.


Laryngeal injection of teflon paste. Report of a case with postmortem study of the larynx.


Gas gangrene. Diagnostic problems and the use of the fluorescent-antibody technique for the study of Clostridium perfringens infections.


Surgical resection for pulmonary metastases in children.


Chemodectoma (non-chromaffin paraganglioma) of the face.


Hormone control of connective tissue.

Hormone control of connective tissue.


The renin-angiotensin system and its relation with the electrolyte balance in experimental hypertension.


Incorporation of C14-lysine in the cell fractions of haemocytoblastosis-changed liver of turkey-poults treated with the leucosis strains MC-29 and MC-31.


Production of acid mucopolysaccharides in mammalian fibroblast tissue cultures transformed by Rous sarcoma virus.


Use of the nucleic acid hybridization method for the demonstration of DNA homologous to Rous virus RNA in RSV-transformed mammalian cells.


Neuromuscular transmission in the longitudinal layer of somatic muscle in the earthworm.


Gas chromatographic detection of in vitro and in vivo activities of certain canine viruses.


Electrophysiological and histological observations on peripheral nerves in acrylamide poisoning in man.


Electrophysiological localization of ulnar nerve lesions.


Transient neurological distrubances in disseminated sclerosis: a case report.


Hypopituitarism with paranoid psychosis: a description of two cases.


Experimental virus-induced hydrocephalus. Relation to pathogenesis of the Arnold-Chiari malformation.


Metastasizing neuroectodermal tumors of the central nervous system.


The comparative effects of estrogens on amylase levels of cervical mucus.


Chronic murine hepatosplenic schistosomiasis mansoni: relative irreversibility after treatment.


Intestinal parasitic infections in the inhabitants of Easter Island.


Low temperature strains of Entamoeba histolytica.


Activity changes of phosphoprotein phosphatase, acid and alkaline phosphomonoesterases and proteinase during oogenesis and embryogenesis in the teleostean fish, Oryzias latipes.


Isolation of adenoviruses from cattle with conjunctivitis and kerato-conjunctivitis.


The urinary excretion of inorganic pyrophosphate in hyperparathyroidism, hyperthyroidism, Paget's disease and other disorders of bone metabolism.


Immunization with inactivated poliovirus vaccine and attenuated type 3 poliovirus. II. Parallel vaccinations and cross-wise revaccination in school children with the Sabin and WM3 attenuated strains.


Extensive intravascular spread of malignant hepatoma.


Herpes virus infections of non-human primates: a review.


Long survival in a male with 18-trisomy syndrome and Wilms' tumor.


Red cell metabolism in the newborn infant. V. Glycolytic intermediates and glycolytic enzymes.


Skeletal maturation of Danish school children in relation to height, sexual development, and social conditions.


Neutralization of murine typhus toxin by serum of normal human beings and monkeys.


Carotid body and aortic body tumors in a dog--a case report.


Experimental exposure of calves to a bovine rhinovirus.


Types of fat cells and histochemistry of some oxidative enzymes in the interscapular adipose tissue of foetal, young and adult guinea pigs.


The occurrence and assay of renin in human urine.


The biological actions of 1,10-phenanthroline and 2,2'-bipyridine hydrochlorides, quaternary salts and metal chelates and related compounds. 1. Bacteriostatic action on selected gram-positive, gram-negative and acid-fast bacteria.


The redox states of respiratory-chain components in rat-liver mitochondria. II. The "crossover" on the transition from state 3 to state 4.


Compound 3 kinetics and chemiluminescence in oscillatory oxidation reactions catalyzed by horseradish peroxidase.


Photosynthesis by isolated chloroplasts. IV. Regulation by factors from leaf cells.


Studies on the chelate structure of the high-potential iron protein of Chromatium.


Some properties of amino acid-acceptor RNA isolated from avian tumour virus BAI strain A (avian myeloblastosis).


An improved method for isolation and identification of hydroxylated testosterone metabolites as trimethylsilyl ethers from biological material.


Studies with ubiquinone-depleted submitochondrial particles. Essentiality of ubiquinone for the interaction of succinate dehydrogenase, NADH dehydrogenase, and cytochrome b.


Biosynthesis of 18-hydroxytestosterone in the human foetal liver.


The reduction of flavins by borohydride: 3,4-dihydroflavin. Struction, absorption and luminescence.


The enzymic hydrolysis of phosphatidyl inositol by guinea pig brain: Sub-cellular distribution and hydrolysis products.


Acetylcholine as a transmitter in the cat auditory system.


Endocytosis of thyroglobulin and the release of thyroid hormone.


Sulfhydryl groups in radiation damage.

Sulfhydryl groups in radiation damage.


Effect of dietary 2-acetylaminofluorene on rat liver enzymes involved in the anabolism and catabolism of nucleic acid precursors.


Energy transfer and radioprotection in biological systems.


High-dosage short-term corticotrophin therapy in acute asthma.


Chemodectoma in relation to the aortic arch (aortic body tumour). A clinical report.


Trial of a new anti-myxovirus compound.

Trial of a new anti-myxovirus compound.


The ACTH cells in the adenohypophysis of the Mexican cave fish Anoptichthys jordani, as identified by metopirone (SU 4885) treatment.


Effect of ACTH and hypophysectomy on the interrenal tissue in the common frog, Rana temporaria.


Adrenergic nerves in the corpora cavernosa penis of some mammals.


Salivary gland scinti-scanning with technetium 99m pertechnetate.


Movements of ventricular fluid levels due to cerebrospinal fluid formation.


Adrenergic mechanisms.

Adrenergic mechanisms.


Initial high dose irradiation for metastases causing spinal cord compression in children.


Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases.


The occurrence of a soluble glucose 6-phosphatase in cotyledon tissue of Phaseolus vulgaris during germination.


Mammalian dihydroorotate--ubiquinone reducatse complex. II. Correlation with cytochrome oxidase, mode of linkage with the cytochrome chain, and general properties.


Effects of x-irradiation of the DNA and ribonuclease levels of guinea-pig (Cavia porcellus) small intestine.


Electrophysiological investigations of the pigeon iris neuromuscular junctions.


Isozymic structure and pyruvate inhibition of lactate dehydrogenase of ventricle, pectoralis muscle and cerebrum, and total LDH activity of cerebrum during morphogenesis of the house sparrow, Passer domesticus.


Acrasin, Acrasinase, and the sensitivity to acrasin in Dictyostelium discoideum.


Inhibition of insulin secretion by aryl-substituted secondary aminoethanols.


Fine needle aspiration biopsy of the liver in healthy adults. Activity of enzymes of glycogen utilization and glucose production.


Quantitative estimation of lactate dehydrogenase isoenzymes in serum. I. Review of methods and distribution in human tissues.


The effect of oestradiol and progesterone on the activity of enzymes in the endometrium and caruncles of the ovariectomized ewe.


Metyrapone and pyrogen tests in hyperadrenocorticism: evaluation of blood corticotropin levels.


Inhibition of the response to pituitary adrenocorticotrophic hormone in the hypophysectomized rat by circulatory corticosterone.


Step-wise resistance to polymyxin and other agents by Pseudomonas aeruginosa.


Premature parturition after infusion of corticotrophin or cortisol into foetal lambs.


Effect of norepinephrine on 32P incorporation into individual phosphatides in slices from different areas of the guinea pig brain.


A chemical method for the determination of acetylcholine: its application in a study of presynaptic release and a choline acetyltransferase assay.


Fractionation of olfactory tissue homogenates. Isolation of a concentrated plasma membrane fraction.


The effect of portacaval transposition and renal artery stenosis on the rejection of renal allografts in dogs.


Purine and pyrimidine nucleotides in the brain of normal and convulsant rats.


Sodium colistimethate (Coly-mycin).

Sodium colistimethate (Coly-mycin).


Feedback suppression of 'non-stress' pituitary-adrenal function in rats with forebrain removed.


Effect of angiotensin on vascular smooth muscles.


Carbon-14 labeled vasoactive peptides available.


Changes of drug resistance of coliform fecal microflora in pigs after total-body x-irradiation.


Immunoassays in the diagnoses of endocrine disorders.


Investigations on the enzymes and toxins of staphylococci. Studies on nuclease.


Investigation on the enzymes and toxins of staphyloccocci. Activity of phosphatase on sugar phosphates, nucleotides and other esters.


Changes in enzyme activity and electrolite content in the myocardium in experimental myocardial hypertrophy and insufficiency.


Alteration in virulence in strains of Cryptococcus neoformans resistant to amphotericin B and polymyxin B.


Reinvestigation of the cause of the increased velocity of reaction between renin and angiotensinogen in plasma from nephrectomised rats.


The adrenal weight of mice with spontaneous adrenocortical lipid depletion. A comparison with untreated, ACTH- and dexamethasone-treated C57B1 mice.


Ocular involvement in neonatal herpes simplex virus infection.


Histometric studies on the adrenal cortex of mice with spontaneous adrenocortical lipid depletion. A comparison with dexamethasone- and ACTH-treated C57B1 mice.


Unilateral corneal anesthesia in oculoauriculovertebral dysplasia.


Optics and visual physiology.

Optics and visual physiology.


Relationship between the active sites of 2',3'-cyclic phosphodiesterase with 3'-nucleotidase activity purified from Vibrio alginolyticus.


Substrates for cytochemical demonstration of enzyme activity. IV. Kinetics of the hydrolysis of thymidine-5'(5-bromo-4-chloroindol-3-YL) phosphate by snake venom phosphodiesterase.


5 Beta-cholestane-3 alpha,7 alpha,12 alpha,26-tetrol:NAD+ oxidoreductase and 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol-26-al:NAD+ oxidoreductase in rat liver.


Ineffectiveness of viomycin-resistant mutants of Rhizobium meliloti.


Collagenase action on the synthetic tripeptide polymers, (gly-pro-ala)n and (gly-ala-pro)n.


Experimental production of diarrhea in rabbits with Clostridium perfringens.


REM deprivation and hyperactivity in children.


The detection of various bacteria indicative of water pollution by a presence-absence (P-A) procedure.


Pyruvate dehydrogenase, substrate specificity and product inhibition.


Ethanol blood levels following acute i.v. administration in mice.


Localization of acetylcholinesterase activity in myotendinous and myomyous junctions of the striated skeletal muscles of the rat.


Effects of diphenylaminoethanol and lidocaine on central inhibition.


The effects of 6-azauridine on the peripheral nervous system. I. The action on ganglionic transmission.


The effect of 6-azauridine on the peripheral nervous system. II. The action on neuromuscular transmission and on striated muscle.


Pharmacological studies on inhibition in the cuneate nucleus of the cat.


Effect of adenosine 3',5'-monophosphate on production of glucose and ammonia by renal cortex. In studies employing rat renal cortical slices, the addition of adenosine 3',5'-monophosphate (cyclic AMP) to the incubation medium caused an increase in production of glucose from glutamine, glutamate, alpha-ketoglutarate, fumarate, malate, and oxalacetate, but not from glycerol and fructose. These observations suggest that cyclic AMP accelerates a rate-limiting gluconeogenic reaction between oxalacetate and the triose phosphates. The addition to the medium of parathyroid hormone, which is known to increase renal cortical cyclic AMP, also stimulated glucose production from glutamine. When renal cortical slices were incubated in the presence of glutamine, the addition of cyclic AMP caused a fall in tissue glutamate concentration and a rise in ammonia production, as well as an increase in gluconeogenesis. These changes are similar to those observed in renal cortex of rats with induced metabolic acidosis. The present observations are consistent with a previously advanced hypothesis that cortical gluconeogenesis, ammonia production, and glutamate concentration may be interdependent.


Normal and abnormal regulation of beta-msh in man. The regulation of plasma beta-melanocyte-stimulating hormone (beta-MSH) in man has been studied utilizing a radioimmunoassay previously described (1). In normal subjects plasma beta-MSH values ranged from 20 to 110 pg/ml. Metyrapone increased and dexamethasone decreased plasma beta-MSH levels. Surgical stress stimulated beta-MSH secretion. Plasma beta-MSH levels were elevated in patients with untreated Addison's disease and untreated congenital adrenal hyperplasia, and these levels fell to normal during glucocorticoid therapy. In patients with Cushing's syndrome due to pituitary adrenocorticotropic hormone (ACTH) excess, plasma beta-MSH was slightly elevated before treatment. In those patients who developed pituitary tumors and hyperpigmentation after bilateral adrenalectomy, plasma beta-MSH was greatly elevated. In patients with Cushing's syndrome due to adrenal tumor, plasma beta-MSH was subnormal. In patients with the ectopic ACTH syndrome, the levels of plasma beta-MSH were high. Plasma beta-MSH had a diurnal variation in normal subjects, patients with Addison's disease, and patients with congenital adrenal hyperplasia; but the normal diurnal variation was lost in patients with Cushing's disease. In patients with high plasma beta-MSH, simultaneous determinations of plasma ACTH showed close correlation between the degree of elevation of ACTH and that of beta-MSH. In extracts of tumors from patients with the ectopic ACTH-MSH syndrome the quantities of the two hormones were roughly equivalent. In patients with hyperpigmentation due to a variety of disorders other than pituitary-adrenal abnormalities, plasma beta-MSH was normal. It is concluded that the secretion of beta-MSH is regulated by the same factors that regulate ACTH.


Cultivation of a filterable agent associated with Marek's disease.


Studies on the role of angiotensin in experimental renovascular hypertension: an immunologic approach. The role of angiotensin in three forms of experimental hypertension was assessed in rats. First, the acute blood pressure response to injected angiotensin amide and angiotensin acid was determined. Rats made hypertensive with deoxycorticosterone and saline showed exaggerated responses; rats made hypertensive by clipping one renal artery showed depressed responses; and rats made hypertensive by clipping one renal artery and contralateral nephrectomy showed normal responsivity to angiotensin amide but depressed responsivity to angiotensin acid. These findings suggested that different mechanisms may be involved in the three types of hypertension studied. To assess the role of angiotensin in these hypertensive rats the blood pressure response, the presence of antibodies determined by radioimmune techniques, and the degree of refractoriness to injected angiotensin after immunization with angiotensin were studied. None of six rats made hypertensive by deoxycorticosterone and saline, and none of five mock immunized rats with renal hypertension of both types had a fall in blood pressure. By contrast, of the 20 rats with both types of renal hypertension in which antibody determinations were made, 11 had developed a significant antibody titer, of which seven showed a significant reduction in blood pressure at the time of antibody determination, and three of the remaining four had a significant blood pressure reduction earlier in their course. None of the nine renal hypertensive rats without demonstrable antibodies had a reduced blood pressure at the time of antibody determination, and only one had an earlier reduction in blood pressure. The renal hypertensive rats were all refractory to injected angiotensin after immunization. These results suggest a primary role for angiotensin in both forms of renal hypertension.


Carcinogenicity and metabolism of aromatic amines in the dog.


Cellular analysis of liver carcinogenesis. 3. Comparison of the ultrastructure of hyperplastic liver nodules and hepatocellular carcinomas induced in rat liver by 2-fluorenylacetamide.


Granular-cell myoblastoma of the larynx.


Comparative stability of benzamide, salicylamide, and some N-substituted derivatives.


Flavonoid antagonism of the spasmogenic effect of angiotensin, bradykinin, and eledoisin on guinea pig ileum.


The interaction of presynaptic polarization with calcium and magnesium in modifying spontaneous transmitter release from mammalian motor nerve terminals. 1. The relationship between motor terminal polarization and miniature end-plate potential (m.e.p.p.) frequency was examined in the presence of various Ca, Mg and K concentrations ([Ca], [Mg] and [K]) and also at modified bathing osmolarity levels. The polarization changes were obtained with ;electrotonic' and ;focal' polarizing currents and with rapid changes in bathing [K].2. M.e.p.p. frequency increased exponentially with electrotonic depolarizing currents, but failed to decrease similarly with hyperpolarizing currents. An increase in bathing [K] to 15 mM increased the sensitivity of the terminals to presynaptic hyperpolarization.3. The slope, on semilogarithmic coordinates, of the function relating m.e.p.p. frequency to electrotonic polarizing currents (the release-current function) was unchanged when bathing [Ca] was raised from 2 to 8 mM. When [Ca] was reduced to 0.5 mM the slope of this function was reduced initially but eventually approached the same slope as in control [Ca]. A similar effect was also found in the presence of 15 mM-KCl.4. The relationship between m.e.p.p. frequency and log [K], at various [Ca], resembled the relationships between m.e.p.p. frequency and presynaptic polarizing currents.5. An increase in bathing [Mg] or osmolarity had a similar effect to a reduction of [Ca].6. Tetrodotoxin (TTX) at a concentration of 10(-6) g/ml. was found to reduce m.e.p.p. frequency, at various [K], by a constant fraction of about 30%.7. In some of the junctions ;anodic break-down' was observed. An examination of this phenomenon with focal polarizing currents disclosed an unusual type of ;anodic break-down', with rapid ;on' and ;off' responses. This phenomenon may indicate that release depends on the influx of positively charged particles into the nerve terminals.8. It is concluded that nerve terminal depolarization accelerates exponentially the activity of a membrane component bearing three Ca molecules, the rate of acceleration being independent of bathing [Ca].


Treatment of otitis externa. Report of a clinical trial.


Tetrodotoxin-resistant electric activity in presynaptic terminals. 1. The electric properties of the giant synapse in the stellate ganglion of the squid have been further investigated.2. During tetrodotoxin (TTX) paralysis, a local response can be elicited from the terminal parts of the presynaptic axons after intracellular injection of tetraethyl ammonium ions (TEA).3. The response is characterized by an action potential of variable size and duration, whose fall is often preceded by a prolonged plateau. The response, especially the duration of the plateau, is subject to ;fatigue' during repetitive stimulation.4. The TTX-resistant form of activity is localized in the region of the synaptic contacts, and shows a marked electrotonic decrement even within less than 1 mm from the synapse. It is found only on the afferent, not on the efferent, side of the synapse.5. During the plateau of the response, the membrane resistance is greatly reduced below its resting value.6. The response depends on presence of external calcium and increases in size and duration with the calcium concentration. Strontium and barium substitute effectively for calcium. Manganese and, to a lesser extent, magnesium, counteract calcium and reduce the response. The response also declines, and ultimately disappears, if sodium is withdrawn for long periods.7. The relation of the local TTX-resistant response to the influx of calcium ions and to the release of the synaptic transmitter is discussed.


Electron spin resonance of an irradiated single crystal of L-tyrosine-HC. Analysis of the electron spin resonance (ESR) of a gamma-irradiated single crystal of L-tyrosine-HCl reveals a free radical formed by loss of an H from the hydroxyl group attached to the ring. Principal g values of the radical are g(x) = 2.0023 +/- 0.0005, g(y) = 2.0067 +/- 0.0005, and g(z) = 2.0045 +/- 0.0005, with g(x) perpendicular to the plane of the ring and g(y) along the CO bond to the ring. Analysis of the hyperfine structure of the spectra shows electron spin density on C((2)) and C((6)) to be 0.24 and on C((4)) to be 0.32. Corresponding spin densities calculated from molecular orbital theory are 0.26 and 0.31, respectively.