Multiple forms of lactate dehydrogenase in Staphylococcus aureus. Activities for nicotinamide adenine dinucleotide (NAD)-dependent and NAD-independent forms of lactate dehydrogenase (LDH) were measured in cell-free extracts of Staphylococcus aureus strain PS 6 for the d and l isomers of lactate. Data obtained for the NAD-dependent lactate dehydrogenases indicate that oxidation of both isomers of lactate is due to both an l-lactate-specific LDH and a lactate racemase. After acrylamide gel electrophoresis, two bands exhibiting LDH activity were detected in crude or in partially purified cell-free extracts. The fast band exhibited LDH activity that was not NAD-dependent for both isomers of lactate, whereas, the slow band had very high NAD-dependent LDH activity for the l isomer but just detectable activity or the d isomer. Both bands appeared when d-lactate was used as the substrate, but only the slow band was formed when l-lactate was the substrate. NAD-dependent LDH, in apparent association with a nonspecific tetrazolium-reducing protein, is responsible for the production of the slow band.


Mechanism of action of the antifungal antibiotic pyrrolnitrin. Pyrrolnitrin at 10 mug/ml inhibited the growth of Saccharomyces cerevisiae, Penicillium atrovenetum, and P. oxalicum. The primary site of action of pyrrolnitrin on S. cerevisiae was the terminal electron transport system between succinate or reduced nicotinamide adenine dinucleotide (NADH) and coenzyme Q. At growth inhibitory concentrations, pyrrolnitrin inhibited endogenous and exogenous respiration immediately after its addition to the system. In mitochondrial preparations, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate-cytochrome c reductase, NADH-cytochrome c reductase, and succinate-coenzyme Q(6) reductase. In addition, pyrrolnitrin inhibited the antimycin-insensitive reduction of dichlorophenolindophenol and of the tetrazolium dye 2,2'-di-p-nitrophenyl-(3,3'-dimethoxy-4,4'-bi-phenylene)5,5'-diphenylditetrazolium. The reduction of another tetrazolium dye, 2-p-iodophenyl-3-p-nitrophenyl-5-phenyltetrazolium chloride, that was antimycin-sensitive, was also inhibited by pyrrolnitrin. The antibiotic had no effect on the activity of cytochrome oxidase, and it did not appear to bind with flavine adenine dinucleotide, the coenzyme of succinic dehydrogenase. In whole cells of S. cerevisiae, pyrrolnitrin inhibited the incorporation of (14)C-glucose into nucleic acids and proteins. It also inhibited the incorporation of (14)C-uracil, (3)H-thymidine, and (14)C-amino acids into ribonucleic acid, deoxyribonucleic acid, and protein, respectively. The in vitro protein synthesis in Rhizoctonia solani and Escherichia coli was not affected by pyrrolnitrin. Pyrrolnitrin also inhibited the uptake of radioactive tracers, but there was no general damage to the cell membranes that would result in an increased leakage of cell metabolites. Apparently, pyrrolnitrin inhibits fungal growth by inhibiting the respiratory electron transport system.


Ileal loop fluid accumulation and production of diarrhea in rabbits by cell-free products of Clostridium perfringens. The ability of cell extracts and culture filtrates of various strains of C. perfringens to produce ileal loop fluid accumulation and overt diarrhea in rabbits was tested. Good correlation was obtained in the ability of whole cells and a toxic factor (present in cell extracts and concentrated culture filtrates) to produce both fluid accumulation in ileal loops and diarrhea when injected into the normal ileum of the rabbit. The toxic factor was present in cell-free preparations when cells were grown in a sporulation medium, but not when they were grown in an asporogenic medium. The factor was shown to be heat labile, nondialyzable, and was inactivated by Pronase but not by trypsin, lipase, or amylase. Loss of activity occurred at pH 1.0, 3.0, 5.0, and 12.0.


Violagabriellae variant of Staphylococcus epidermidis on normal human skin. Twenty-seven strains of a reddish violet pigment-producing variety of Staphylococcus epidermidis have been recovered from normal human skin. They closely resemble the previously unique Castellani strain, named Micrococcus violagabriellae, which was placed by K. J. Steel in S. epidermidis. These strains are classified as S. epidermidis by using the Baird-Parker schema; however, besides the pigment produced, they also differ from S. epidermidis in proteolytic activity and effect on litmus milk. The variety seems to be part of the normal flora of the human axilla.


The effects of glucagon, dibutyryl cyclic adenosine 3',5'-monophosphate, and concentration of free fatty acid on hepatic lipid metabolism.


Hormonal regulation of transfer ribonucleic acid and transfer ribonucleic acid-methylating enzymes during development of the mouse mammary gland.


An extracellular nuclease from Serratia marcescens. II. Specificity of the enzyme.


Insulin-receptor interaction in isolated fat cells. I. The insulin-like properties of p-chloromercuribenzene sulfonic acid.


Effect of thyroid-stimulating hormone and prostaglandins on thyroid adenyl cyclase activation and cyclic adenosine 3',5',-monophosphate.


Kinetics of malic-lactic transhydrogenase. Abortive complex formation with substrates and products.


Purification and properties of lactaldehyde dehydrogenase from Escherichia coli.


Reconstitution of succinate-coenzyme Q reductase (complex II) and succinate oxidase activities by a highly purified, reactivated succinate dehydrogenase.


Synthesis of carbamyl phosphate synthetase in amphibian liver in vitro. The effect of thyroxine.


Inhibition of horse liver alcohol dehydrogenase by L-3,3',5-triiodothyronine.


Transplantable hepatomas induced in strain-2 guinea pigs by diethylnitrosamine: characterization by histology, growth, and chromosomes.


Antigenic specificity of hepatomas induced in strain-2 guinea pigs by diethylnitrosamine.


Tumor-specific antigens: detection by local transfer of delayed skin hypersensitivity.


Propagation and behavior in chicken kidney cultures of the agent associated with classical Marek's disease.


Localization of viral antigen in chickens infected with Marek's disease herpesvirus.


Recovery of a hamster-specific, focus-forming, and sarcomagenic virus from a "noninfectious" hamster tumor induced by the Kirsten Mouse sarcoma virus.


Host-tumour relationship. XXV. Hyaluronidase activity in blood serum and ascitic fluid of rats during growth of transplanted tumours.


Enhanced virus content of chicken tumours induced by the Schmidt-Ruppin strain of Rous sarcoma virus.


Biological role of charge transfer complexes of aromatic hydrocarbon oxi-derivatives in chemical carcinogenesis.


A quantitative study on transformation of hamster embryo cells in vitro by murine sarcoma viruses (Harvey and Moloney).


Study of poliovirus infection of human and monkey cells by indirect immunoferritin technique.


Specific requirement of serine for the growth of Newcastle disease virus.


Studies on EB virus of Burkitt's lymphoblasts.


Cellular DNA and protein synthesis in reovirus-infected L cells.


Newer viral exanthems.

Newer viral exanthems.


Nonchromaffin paraganglioma of the orbit.


Cuproproteins: a model and system derived from tricyanoaminopropene (TRIAP) and copper.


Structure and function in mycoplasma.

Structure and function in mycoplasma.


Peripheral neuropathy in tropical (nutritional) ataxia in Nigeria. Light and electron microscopic study.


Paradoxical sleep rebound in the rat. Effects of physical procedures involved in intracisternal injection.


Inhibitory synaptic pathways linking specific and nonspecific thalamic nuclei.


Osteocytic osteolysis.

Osteocytic osteolysis.


Correlation of psychological variables and progress in physical rehabilitation.


Studies on the 19S type immunological memory to phi chi 174 phage in an in vitro system.


Endocrine aspects of child psychoses.

Endocrine aspects of child psychoses.


The effect of sodium barbitone, alone and together with ACTH and amphetamine, on the behaviour of the rat in the multiple "T" maze.


The effect of angiotensin on the heart rate of the turtle.


The antibody response and morphological changes following immunization of pig foetuses with phi chi 174 phage.


Pharmacological properties of feline red nucleus.


Isolation of the anti-inflammatory principles from Achillea millefolium (Compositae).


Vesicular stomatitis virus (VSV) infection in rabbit eye: role of antibody and interferon.


Herpes simplex virus pneumonia. Occurrence in an allotransplanted lung.


Clinical experience using dehydrated corneal grafts in large corneal wounds.


Regulation of insulin secretion.

Regulation of insulin secretion.


Studies on the metabolites of vitamin D.


Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein.


On the formation of the superoxide anion radical during the reaction of reduced iron-sulfur proteins with oxygen.


Changes in glycogen synthetase and phosphorylase during muscular contraction.


Inactivation of rat liver glycogen synthetase by 3':5'-cyclic nucleotides.


DNA-dependent RNA polymerase from E. coli: studies on the role of sigma in chain initiation.


Platelet aggregation. I. Regulation by cyclic AMP and prostaglandin E1. Platelet aggregation plays a major role in thrombogenesis.  This study was undertaken to examine the inhibition of platelet aggregation induced by adenosine diphosphate.  It is known that cyclic AMP (adenosine monophosphate) and its dibutyryl derivative inhibit platelet aggregation.  This study showed that prostaglandin E1 (PGE1) also inhibits platelet aggregation and stimulates cyclic AMP synthesis by stimulation of adenyl cyclose.  Caffeine, on the other hand, inhibits platelet phosphodiesterase, and increases cyclic AMP levels.  PGA1 and PGF1 alpha can also inhibit platelet aggregation but only at very high concentrations.


Muscle-type aldolase isolated from a liver tumor.


Mammary tumor virus (MTV) virions in a transplantable ependymoblastoam.


Interstrain resistance to polyoma virus oncogenesis and runting in inbred mice treated with antilymphocyte serum (ALS).


Effect of dihydroergotamine and propranolol on dibutyryl cyclic 3',5'-AMP-induced lipolysis in isolated rat fat cells.


Tumor antigens. II. Immunological studies of tissue and tumor antigens and serum protein production by murine interstitial cell tumors of the testis and a hepatoma.


The epithelial-connective tissue junction as seen after enzymatic digestion.


Correlation between propagation of a bovine enterovirus and development of receptor-like material in tissue mince.


Glucose-6-phosphate dehydrogenase in normal and malignant mouse tissues and cells propagated in vitro.


Transformation of odontogenic epithelium by polyoma virus in vitro.


The effect of alterations in external environment on the dentogingival junction.


Further observations on the inhibitory effect of myxoviruses on a transplantable murine leukemia.


Influence of polyamines on induction of interferon and resistance to viruses by synthetic polynucleotides.


Lipolytic activity of ribonucleotide and deoxyribonucleotide 3',5'-cyclic monophosphates in isolated rat fat cells.


The origin of collagenase in periodontal tissues of man.


Methanol solubility of acid-precipitated proteins: a possible source of error in incorporation studies.


Induction of tumor-specific transplantation immunity in hamsters with cell fractions from adenovirus and SV40 tumor cells.


Typing of Herpesvirus hominis strains by a direct immunofluorescent technique.


Normal myocardial adenyl cyclase activity in hyperthyroid cats.


Effect of antibiotics on bacterial flora of rats with intestinal blind loops.


Polyinosinic-cytidylic acid complex (poly I:C) and viral infections in mice.


Concanavalin A-induced sensitization of mice to histamine.


Electron and fluorescence microscopical studies on the nucleus caudatus putamen of the rat after unilateral lesions of ascending nigro-neostriatal dopamine neurons.


Studies on experimental cerebral edema. I. Modification of glial triphosphatase activity in cerebral edema of the cat.


Herpes simplex encephalitis.

Herpes simplex encephalitis.


Role of virucides in controlling virus dissemination by fabrics.


Glial footplates in the bowfin. I. Fine structure and chemistry.


Membranous structures associated with translation and transcription of poliovirus RNA. Poliovirus RNA and proteins are synthesized in association with distinct membranous structures that were separated by means of Isopycnic centrifugation of cytoplasmic extracts in discontinuous sucrose-density gradients. Viral RNA is replicated in a structure that contains rapidly labeled replicative intermediate RNA and viral RNA polymerase associated with the smooth membrane fraction. In sucrose gradients this viral RNA replication complex is distributed at densities in the range of 1.12 to 1.18 grams per cubic centimeter. Viral proteins are synthesized on polyribosomes bound to membranes and sediment with polyribosomes at densities of less than 1.25 grams per cubic centimeter.


Absence of catecholamines from islet cells of human pancreas and a beta-cell tumour in man.


Growth in children with thalassaemia major and effect of two different transfusion regimens.


The effect of alpha-methyldopa on the vasoconstrictor responses of the rat mesenteric artery preparation to nerve stimulation.


Effect of sympathomimetic amines on the response of the perfused mesenteric artery preparation to adrenergic nerve stimulation.


Effects of radiation on the central nervous system.


The peripheral neuropathy of Krabbe's (globoid) leukodystrophy.


Motor unit frequency control in facial neuropathy.


From target-theory to molecular radiobiology.


The inner membrane of the rat liver mitochondrion as the site of incorporation of radioactively labeled precursors into nucleic acid and protein in vitro.


Purification and properties of 3-phosphoglyceric acid mutase from caprine erythrocytes.


Phosphorylation linked to ascorbate oxidation in Mycobacterium phlei.


Phosphoserine phosphatase: development formation and hormonal regulation in rat tissues.


Carbonyl groups associated with mitochondrial ATP synthesis.


Isoenzymes of beta-isopropylmalate dehydrogenase from Pseudomonas aeruginosa.


Effects of dinitrophenol, dicyclohexyl carbodimide and oligomycin on respiration, glycogen synthesis, and glycolysis in Novikoff ascites-hepatoma cells.


Neuroendocrinological studies in mental disorders and psychotropic drugs. I. On the circadian rhythm of the plasma adrenocortical hormone in mental patients and methamphetamine- and chlorpromazine-treated animals.


The determination of ammonia in arterial and venous blood by immediate fixation.


Giant pleomorphic nuclei in the hamster-adenovirus tumor cell lines after treatment with HVJ.


Studies on siomycin. I. Physicochemical properties of siomycins A, B and C.


Studies on the factor, responsible for increased triglyceride synthesis in tetracycline-treated rat.


Studies on microbial degradation of carbenicillin.


Increase of glycogen and oligosaccharide contents in ascites tumor cells under the influence of alkylating agents.


Notes on laboratory colonization of Culex tritaeniorhynchus summorosus, the principal vector of Japanese encephalitis in Japan.


Changes in ultrastructure and synaptic transmission in the sympathetic ganglion during various metabolic conditions.


Presynaptic spike and excitatory postsynaptic potential in sympathetic ganglion: their modifications by pharmacological agents.


Synaptic transmission in the senosry relay neurons of the thalamus.


Forms of spontaneous and evoked postsynaptic potentials of cortical nerve cells.


The functional organization within the ommatidium of the lateral eye of limulus.


Effects of catecholamines in the cat superior cervical ganglion and their postulated rôle as physiological modulators of ganglionic transmission.


Metabolic effects of nerve impulses and nerve-growth factor in sympathetic ganglia.


Effect of carbon tetrachloride on the rates of lipid peroxidation and hydrolysis of pyrophosphates in isolated mitocondria.


Metallocinium cations, nucleic acids and proteins.


The hypersensitivity of adipose tissue to norepinephrine and other lipolytic agents during blockade of free fatty acids (FFA) mobilization.


Distribution and metabolism of the periodate oxidation product of 9-beta-D-ribosyl-6-methylthiopurine.


Studies on immunosuppression by purine nucleoside analogues. I. Effects on the immune response to sheep red blood cells in mice.


Cooperative and non-cooperative conformational effects of the coenzyme on yeast glyceraldehyde-3-phosphate dehydrogenase.


Model experiments for the study of iron transfer from transferrin to ferritin.


The effect of 5-hydroxytryptamine, dimethylphenylpiperazinium and acetylcholine on transmission and surface potential in the cat sympathetic ganglion.


Importance of the calcium ion in rhythmic fluctuation in renal pressure produced by angiotensin II.


A new ganglion-stimulating compound: 2-imino-1,3-diaza-4-carboxyethyl cycloheptane hydrochloride (OG 30).


Structure of the DNA of bacteriophage fd. I. Absence of non-phosphodiester linkages.


Antitumor activity of mycophenolic acid.


Water pollution. Microbiology.

Water pollution. Microbiology.


Outline of purification and some properties of histamine-sensitizing factor from Bordetella pertussis.


Studies on the mechanism of action of salicylates. VII. Effect of a few anti-inflammatory agents on uridine-5'-diphosphoglucose dehydrogenase.


Chemical carcinogenesis with DAB and lysosome.


Antigenic structure and phase variation in Bordetella pertussis.


Silicoextraction of senile and complicated cataracts.


The similarities of the angiotensin and bradykinin action on the central nervous system.


The adrenergic innervation of the human parotid gland.


Histochemical studies on the release of the adrenergic transmitter by nerve impulses in combination with drugs, especially adrenergic neuron blocking agents.


Involvement of adenosine 3',5'-monophosphate in release of ACTH.


The epidemiology of amoebiasis.

The epidemiology of amoebiasis.


Persistent infection with herpes simplex virus in vitro. 1. Establishment and characteristics of persistent herpes simplex virus infection in Earle's L cells.


Intermittent corticotrophin therapy. Study of lymphocyte transformation in vitro in rheumatoid arthritis.


The oxidation-reduction potential of copper in cytochrome oxidase.


Isolation of a tetrasaccharide common to MM, NN and MN antigens.


Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli.


Evidence that 3-phosphoserine may be a precursor of vitamin B6 in Escherichia coli.


Localization of isotope from (2-14C) glucose and (6-14C) glucose in deoxypentose moieties of herpes simplex DNA.


Intramolecular energy transfer in adrenocorticotropin.


Effects of added nucleotides on renal carbohydrate metabolism. 1. The regulatory effects that adenine nucleotides are known to exert on enzymes of glycolysis and gluconeogenesis were demonstrated to operate in kidney-cortex slices and in the isolated perfused rat kidney by the addition of exogenous ATP, ADP and AMP to the incubation or perfusion media. 2. Both preparations rapidly converted added ATP into ADP and AMP, and ADP into AMP; added AMP was rapidly dephosphorylated. AMP formed from ATP was dephosphorylated at a lower rate than was added AMP, especially when the initial ATP concentration was high (10mm). Deamination of added AMP occurred more slowly than dephosphorylation of AMP. 3. Gluconeogenesis from lactate or propionate by rat kidney-cortex slices, and from lactate by the isolated perfused rat kidney, was inhibited by the addition of adenine nucleotides to the incubation or perfusion media. In contrast, oxygen consumption and the utilization of propionate or lactate by slices were not significantly affected by added ATP or AMP. 4. The extent and rapidity of onset of the inhibition of renal gluconeogenesis were proportional to the AMP concentration in the medium and the tissue, and were not due to the production of acid or P(i) or the formation of complexes with Mg(2+) ions. 5. Glucose uptake by kidney-cortex slices was stimulated 30-50% by added ATP, but the extra glucose removed was not oxidized to carbon dioxide and did not all appear as lactate. Glucose uptake, but not lactate production, by the isolated perfused kidney was also stimulated by the addition of ATP or AMP. 6. In the presence of either glucose or lactate, ATP and AMP greatly increased the concentrations of C(3) phosphorylated intermediates and fructose 1,6-diphosphate in the kidney. There was a simultaneous rise in the concentration of malate and fall in the concentration of alpha-oxoglutarate. 7. The effects of added adenine nucleotides on renal carbohydrate metabolism seem to be mainly due to an increased concentration of intracellular AMP, which inhibits fructose diphosphatase and deinhibits phosphofructokinase. This conclusion is supported by the accumulation of intermediates of the glycolytic pathway between fructose diphosphate and pyruvate. 8. ATP or ADP (10mm) added to the medium perfusing an isolated rat kidney temporarily increased the renal vascular resistance, greatly diminishing the flow rate of perfusion medium for a period of several minutes.


Nuclear magnetic resonance study of the conformation of nicotinamide--adenine dinucleotide and reduced nicotinamide--adenine dinucleotide in solution.


Reversible dissociation of yeast glyceraldehyde 3-phosphate dehydrogenase by adenosine triphosphate.


Kinetics of the oxidation of benzyl alcohol by acid permanganate.


In vitro ACTH assay: influence of strain on responsiveness of rat adrenals.


Cytomegalovirus infection. A case report.


The action of glycine on cortical neurones.


Separation of specific antibodies to TSTAs of adeno 12 and polyoma tumors.


The properties of sarcomas induced in Wistar rats byRous sarcoma virus (Schmidt-Ruppin).


Activation of Rous virus in the transplanted golden hamster tumour with the aid of artificial heterokaryon formation.


Oocyte destruction and ovarian tumorigenesis after direct application of a chemical carcinogen (9:0-dimethyl-1:2-benzanthrene) to the mouse ovary.


Pulmonary adenomatosis in opossums (Didelphis virginiana).


Epidermal changes caused by squirrel poxvirus.


A report of three bile duct carcinomas occurring in pigeons.


Isolation and characterization of paecilomycerol, a new steroidal antiviral antibiotic. Studies on antiviral and antitumor antibiotics. XXI.


Multiple endocrine adenoma peptic ulcer complex. Clinicopathological study of a case.


Terminal respiration in minute mutants of Drosophila.


Some characteristics of hemagglutination of certain strains of "IBV-like" virus.


Application of antibiotic ointment to the site of venous catheterization--a controlled trial.


Risk of infection with intravenous indwelling catheters: effect of application of antibiotic ointment.


Metabolites of vitamin D3 and their biologic activity.


Mechanism of persistent herpes simplex virus infection in vitro.


The management of massive pulmonary embolism following hysterosalpingography.


The effect of zinc on the production of various toxins of Clostridium perfringens.


Studies on the biosynthesis of nuclear asis proteins. I. Incorporation of L-lysine-14C in isolated rat hepatoma nuclei.


The effect of calcium on the production of various toxins of Clostridium perfringens.


Methods of sampling population of the Japanese encephalitis vector mosquitoes. A preliminary report.


Syringocystadenoma papelliferum.

Syringocystadenoma papelliferum.


Hypermineralocorticoid-induced hypertension.


Antibody response in piglets by simultaneous inoculation with attenuated viruses of Japanese encephalitis and hog cholera.


Hemagglutin of Japanese encephalitis virus produced in embryonic swine kidney cell cultures.


Growth characteristics and persistent infection of Japanese encephalitis virus in bovine kidney cell culture at different temperatures.


Response of swine to an attenuated strain of Japanese encephalitis virus obtained by passage in bovine kidney cell cltures.


Structural relationships in microbial peptides.


Inhibitory effect of a synthetic interferon inducer on murine sarcoma and leukaemia virus infection in vitro.


Neutralization of Graffi leukaemia virus.


Cyclic 3',5'-adenosine monophosphate in human blood platelets.


Lung tap in childhood. Bacteria, viruses, and mycoplasmas in acute lower respiratory tract infections.


Rapid eye movements and dream imagery: are they related?


Antibiotics and their effect on Bordetella pertussis in the nasopharynx.


Comparative decay characteristics of the light generated free radical in chromatophores and chloroplasts.


Isolation and purification of an alkaline ribonuclease from human placenta.


Accumulation of azide in mitochondria and the effect of azide on energy metabolism.


Subcellular distribution and function of ubiquinone in Salmonella typhimurium.


Histochemical studies on the distribution of esterases, monoamine oxidase and dephosphorylating enzymes in the area postrema of the squirrel monkey.


Quantitative determination of phosphoinositides.


The structure of myo-inositol pentaphosphates.


Inositol phosphates, glycosides, and some 5-carbon cyclitols.


Some characteristics of the d-glucose-6-phosphate: cycloaldolase (NAD+ dependent) from Neurospora crassa.


Studies on myo-inositol metabolism in galactosemia.


Physical properties and interactions of phosphoinositides.


Ion-exchange chromatography of inositol polyphosphates.


Aspects of phosphate ester chemistry as applied to the phosphoinositides.


Functional activity in glands and synaptic tissue and the turnover of phosphatidylinositol.


Acetylcholine-stimulated phosphodiesteratic cleavage of phosphoinositides: hypothetical role in membrane depolarization.


Metabolism and function of polyphosphoinositides in nervous tissue.


Physiological significance of polyphosphoinositides in brain.


Polyphosphoinositide biosynthesis in developing rat brain homogenates.


The metabolism of the polyphosphoinositides in kidney: studies on the phosphatidylinositol kinase.


Plasma cortisol monitoring and use of ACTH in asthma.


Quantitative determination in urine of hippuric acid and m- or p-methylhippuric acid, metabolites of toluene and m- or p-xylene.


The effects of respiratory acidosis on a sensory relay system.


Rous sarcomas in mice: the chromosomal progression in primary tumours.


Lipid content and composition of the tse-tse fly, Glossina morsitans Westwood.


Interference between tow strains of the mouse mammary tumour virus in the GR mouse strain.


Sequential effects of chemically different carcinogens, dimethylnitrosamine and 4-dimethylaminoazobenzene, on hepatocarcinogenesis in rats.


Transplantable mouse tumor line induced by injection of SV40-transformed mouse kidney cells.


The lipids of normal diploid (WI-38) and SV40-transformed human cells.


Some factors affecting carbohydrate metabolism in hepatic tissues of different growth rates.


Studies on P-450. VI. The spin state of P-450 solubilized from bovine adrenocortical mitochondria.


Cerebral and visceral glycolipids in a case of Tay-Sachs disease.


Regenerative loop.

Regenerative loop.


EPR studies on cytochrome oxidase at 20 degree K.


Granular cell myoblastoma in the thyroid gland. Report of a case.


Studies on chemically modified cytochrome c. II. The trinitrophenylated cytochrome c.


The internal-external bonds of the memory process.


Altered states of awareness.

Altered states of awareness.


Spectrophotometric and electron spin resonance studies of NADH2-cytochrome c reductase complex.


An experimental study on the phagocytosis of ascites tumor cells against benzidine yellow system pigments.


Parallel changes in cytoplasmic and mitochondrial redox state of rat liver. Effects of ethanol, sorbitol and thyroid hormones.


Effect of phenethyl alcohol on bacterial bioluminescence.


Multiple tumors of the major salivary glands.


Cancer of the sublingual salivary gland.


Isolation of a canine herpesvirus from a dog with malignant lymphoma.


Serologic evidence of bluetongue in wild ruminants of North America.


Secretory characteristics of phaeochromocytoma and related tumours. Their diagnostic and clinical significance.


Mucous-secreting cyst of the middle ear. Possible origin from the first pharyngeal pouch.


Neonatal inclusion conjunctivitis in Australia.


Pseudorenin. A new angiotensin-forming enzyme.


Antilymphocytic serum in experimental allergic encephalomyelitis. Antilymphocytic and antithymic sera (raised in rabbits) are highly potent in preventing or alleviating experimental allergic encephalomyelitis in guinea-pigs. Good results are obtained when treatment is begun as late as 10 days after challenge. No protracted disease was seen from the use of antilymphocytic serum. Attempts to use this serum therapeutically once the disease was clinically established gave equivocal results. Antilymphocytic serum appears to have a non-specific stressor effect as well as its specific action, and possibly this adrenocorticotrophic-hormone (antiphlogistic) effect may ameliorate a developing encephalitis. The presence of an antimacrophagic factor in antilymphocytic serum may be important in increasing local reaction to injection of the serum and perhaps also in diminishing the appearance of haematogenous elements in the nervous lesions.


Mechanism of action of epinephrine and glucagon on the canine heart. Evidence for increase in sarcotubular calcium stores mediated by cyclic 3',5'-AMP.


The nursing referral program in a V.A. hospital.


Structural and functional characterization of dog heart microsomes.


Radioimmunoassay of peptide hormones.

Radioimmunoassay of peptide hormones.


Cystosarcoma phyllodes. A study of 15 cases.


Decreased interferon sensitivity and production in cells transformed by SV40 and other oncogenic agents.


Induction experiments with adenovirus and polyoma virus transformed cell lines.


Concomitant immunity in hamsters bearing DMBA-induced tumor transplants.


The antigenic structure of nephroblastomas.


Further experience using cryosurgery in otolaryngology.


Pathologic findings in brain tumors treated with local methotrexate.


A review of current laboratory studies with Entamoeba histolytica.


Adrenal secretion of androgens and oestrogens.


A comparison between the uptakes of radioactive perchlorate and iodide by rat and guinea-pig thyroid glands.


The fate of free and conjugated oestrogens injected into the Graffian follicle of equines.


Depressors of interferon synthesis: further studies on the production, action and properties of the so-called enhancer.


Purification of Encephalomyocarditis virus.


Radioautographic evidence of DNA synthesis in well-differentiated cells of human skin papillomas (verrucae vulgares).


Antimicrobial therapy in theoy and practice. I. Clinical pharmacology.


Antimicrobial treatment of pertussis.

Antimicrobial treatment of pertussis.


Cytomegalovirus infections in newborn infants.


Simultaneous determination of thiamine and 2-(1-hydroxyethyl) thiamine in biological materials.


Reaction products of vitamin D3 with Nield reagent, bisteroids A and B.


Effect of vitamin D3 on the calcium binding factor in rat intestinal mucosa.


Role of ring substitution on the inhibition of nicotinamide adenine dinucleotide dependent oxidations by 2-methyl-3-ortho-tolyl-6-hydroxy-4-quinazolone.


The response of human gastric tissue eosinophils to ACTH infusion and to long-term treatment with prednisone.


The mechanism of photosynthesis.

The mechanism of photosynthesis.


Cell transformation by viruses.

Cell transformation by viruses.


Polyol pathway in aorta: regulation by hormones. Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.


Preliminary observations on Marek's disease in ducks and other avian species.


Regional enteritis and entero-colitis: a study of 74 patients over 15 years.


Cyclic 3',5'-nucleotide phosphodiesterase of fish (Salmo gairdnerii) brain.


Influence of hyperthyroidism on the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state.


Effect of ovariectomy on pituitary secretion of ACTH.


Effects of chlorpromazine and propranolol on in vitro thyroid activation by thyrotropin, long-acting thyroid stimulator and dibutyryl cyclic-AMP.


Actinomycin D in vivo: paradoxical and nonspecific effects on adrenal cortex.


In vitro release of ACTH: effects of potassium, calcium and corticosterone.


Formation of estrogens by the pregnant mare. I. Metabolism of 7-3H-dehydroisoandrosterone and 4-14C-androstenedione injected into the umbilical vein.


Corticosteroid synthesis in adrenal enucleated rats before the onset of hypertension.


Effects of ACTH and cyclic-AMP in vitro on incorporation of 3H-leucine and 14C-orotic acid into protein and RNA in the presence of an inhibitor of cholesterol side chain cleavage.


The separation of rat liver cells in colloidal silica-polyethylene glycol gradients.


Autoradiographic studies of HeLa-S3 cells persistently infected with hemadsorption type 2 virus.


Development of SV40 coat protein antigen in nonpermissive nuclei in heterokaryocytes.


Measurement of plasma aldosterone by gas chromatography with electron capture detection.


[Estriol "clearance" and creatinine clearance during normal spontaneous labor and labor induced by oxytocin infusion].


Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.


Prophylaxis and treatment of endemic goiter in Peru with iodized oil.


Hyperaldosteronism in hypertensive congenital adrenal hyperplasia.


Circadian rhythms of plasma growth hormone and cortisol after insulin.


Evidence for a two-pool system governing the excretion of radioactive urinary estrogen conjugates during the first eight hours following the administration of extrone-6,7-3H to male subjects. Probable role of the enterohepatic circulation.


Constant light: effect on circadian pattern and phase reversal of steroid and electrolyte levels in man.


Effect of circulating fragments of angiotensin II on radioimmunoassay in arterial and venous blood.


Lasting biological effects of early environmental influences. IV. Notes on the physicochemical and immunological characteristics of an enterovirus that depresses the growth of mice. Physicochemical and immunological techniques have been used in an attempt to characterize a filterable agent, separated from the intestines of mice raised under ordinary conditions of husbandry, which produces a lasting depression of weight in specific pathogen-free (SPF) mice when administered to them orally shortly after birth. Although this agent has not yet been identified, it will be tentatively designated here as enterovirus. The mouse enterovirus can be readily sedimented by ultracentrifugation and by precipitation at pH 4.3; it does not pass through cellophane membranes. Its infective power is completely destroyed by ultraviolet radiation, but is resistant to heating at 56 degrees C, exposure to ether, treatment with trypsin, ribonuclease, and deoxyribonuclease. Dialysis and treatment with ether and nucleases greatly increase the infective activity of the intestinal filtrates containing the enterovirus, a finding which suggests that these procedures eliminate or destroy some inhibitory substance(s). The mouse enterovirus causes hemagglutination of mouse red blood cells. When injected into rabbits, it elicits in them an immune response that renders their serum capable of neutralizing its weight-depressing activity. As measured by inhibition of hemagglutination or complement fixation, the sera of infected mice do not exhibit any significant activity against usual mouse viruses. Centrifugation of the mouse enterovirus in 50%-20% sucrose gradient gave almost complete recovery of the infectivity and of hemagglutinating activity in the same fraction. In contrast, the protein content of the material was distributed through the various fractions. Consequently, this procedure resulted in a marked increase of specific activity.


Functional characterization of neuronal circuitry of frog cerebellar cortex.


Neuronal interactions in frog cerebellum.


Posttetanic potentiation of monosynaptic and disynaptic actions from supraspinal structures on lumbar motoneurons.


Afferent inhibition at input to visual cortex of the cat.


Bovine splenic nerve: characterization of noradrenaline-containing vesicles and other cell organelles by density gradient centrifugation. 1. Homogenates of bovine splenic nerves were subjected to differential and sucrose density gradient centrifugation. From the low-speed supernatant a high-speed sediment (mitochondria, lysosomes, microsomes and noradrenaline (NA) vesicles) was obtained. By density gradient centrifugation of this sediment it was shown that NA vesicles are slightly less dense than mitochondria, but denser than microsomes.2. In further experiments a mitochondrial and a microsomal sediment were obtained. The mitochondrial sediment was fractionated with a short centrifugation time over a density gradient ranging from 0.6 to 1.2 M sucrose. Mitochondria (fumarase and succinate-dehydrogenase) and lysosomes (acid ribonuclease and deoxyribonuclease) sedimented to the bottom of the tube. The highest concentration of NA vesicles was found in a medium position. There was only a small amount of microsomes (glucose-6-phosphatase) present.3. The microsomal sediment was centrifuged for 150 min over a density gradient ranging from 0.8 to 1.4 M sucrose. The microsomes remained on the top of the gradient. There were also some mitochondria and lysosomes present. The NA vesicles were found in highest concentration in the middle of the gradient (at about 1.2 M sucrose).4. With the use of these two density gradients, the subcellular distribution of dopamine-beta-hydroxylase, monoamine oxidase and ATPase was studied. Dopamine-beta-hydroxylase was found to be localized in the NA vesicles. Monoamine oxidase was mainly recovered in mitochondria; a small part of the enzyme appeared to be microsomal. ATPase was present in microsomal elements.


Hydronephrosis secondary to ureteral obstruction by metastatic breast cancer.


Progressive ventral sensory loss in sensory radicular neuropathy and hypertrophic neuritis.


Clinical studies on interferon. I. Interferon production in children with viral diseases.


Silent reversal of acromegaly: pituitary apoplexy resulting in panhypopituitarism.


Inhibition of the effects of angiotensin II on adrenal steroid production by dietary sodium. The pressor octapeptide, angiotensin II, can stimulate the production of aldosterone by the adrenal cortex. The present results show that in the dog a high-sodium diet can eliminate the steroidogenic action of angiotensin II, which is thus dissociated from the pressor action which remains. Angiotensin II was infused intravenously for 48 hours into conscious, undisturbed hypophysectomized dogs that were receiving each day either 60 or 200 mEq of dietary sodium. Blood pressure and secretion of aldosterone, corticosterone, and cortisol were measured (1) throughout the infusion in some dogs, and (2) at the end of the infusion in all dogs. In those dogs receiving 60 mEq of sodium, angiotensin II elevated the blood pressure and produced sustained increases of secretion of aldosterone, corticosterone, and cortisol. In those dogs receiving 200 mEq of sodium, angiotensin II, while retaining its pressor activity, had no effect on the production of aldosterone, corticosterone, or cortisol after 24 hours. Thus, if angiotensin II can produce hypertension clinically, there need not be secondary aldosteronism as well.


Genetic control by the hr-locus of susceptibility and resistance to leukemia. Leukemia was observed in 45 per cent of hairless mice at 8 to 10 months of age and 72 per cent at 18 months. The incidence of leukemia in normal heterozygous mice of the same age is about one per cent at 10 months and increases to 20 per cent at 18 months. Other tumors are rare; two mammary adenocarcinomas occurred in heterozygotes, and an epidermal squamous cell carcinoma was found in a hairless mouse. Murine leukemia virus was isolated from normal and leukemic mice of both genotypes on SWR/J- and C57L/J-METC, but not BALB/cJ-METC. If this virus is responsible for the leukemia in HRS/J mice, the mutant gene (hr) enhances susceptibility and the wild-type allele (+) induces resistance to leukemogenesis, i.e., malignant transformation of reticulo-endothelial tissues occurs rather than inhibition of viral replication as both genotypes harbor virus in high titers. The two types of HRS/J mice, hr/hr and hr/+, are congenic, i.e., they differ only with respect to one allele (hr or +) at the mutant locus. This single gene difference should lend itself to analysis of the interaction of a specific gene and murine leukemia virus.


Replication and properties of DNA in nicotinamide adenine dinucleotide deficiency of Escherichia coli cells. When niacin-requiring E. coli was starved of niacin, a precursor of nicotinamide adenine dinucleotide (NAD), the cells elongated and synthesis of DNA was inhibited while syntheses of RNA and protein continued. The cellular NAD concentration decreased to less than one tenth of the normal level in niacin deficiency, but no change in DNA ligase level was detected. The apparent inhibition of DNA synthesis can be explained as due to reduction in the activity of the cofactor, NAD, for the enzyme. The DNA synthesized in this state was small in an alkaline sucrose gradient but of normal size in a neutral sucrose gradient. The molecules had a double-stranded structure, as judged by hydroxyapatite chromatography. The small pieces of DNA were integrated into normal-size DNA molecules on addition of niacin, when the cellular NAD concentration was restored to the normal level but DNA synthesis was not. It is suggested that this small DNA is an intermediate in DNA replication.


Stimulation of anterior pituitary adenyl cyclase activity and adenosine 3':5'-cyclic phosphate by hypothalamic extract and prostaglandin E1. Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3':5'-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E(1) also increased adenyl cyclase activity and cyAMP levels in anterior pituitary tissue. Although NaF augmented adenyl cyclase activity, it did not elevate cyAMP. Epinephrine, norepinephrine, histamine, serotonin, dopamine, and vasopressin did not increase either adenyl cyclase or cyAMP. The increased adenyl cyclase and cyAMP produced by hypothalamic extract was associated with greater luteinizing hormone release from anterior pituitary in vitro.


Hemoglobin A: an electron paramagnetic resonance study of the effects of interchain contacts on the heme symmetry of high-spin and low-spin derivatives of ferric alpha chains. Hemoglobin, the oxygen-binding heme protein of blood is composed of four subunits of two types, alpha and beta. Although the protein when isolated is diamagnetic, by oxidation it can be converted to various paramagnetic ferric forms exhibiting specific electron paramagnetic resonance (EPR) spectra. Using electron paramagnetic resonance, we have shown that the symmetry of the heme of isolated ferric alpha chains is different from that of the heme of these same subunits when associated with ferric beta chains in the parent tetramer. The high-spin form of the isolated ferric alpha chains shows a clearly resolved departure from tetragonal symmetry in contrast to ferrihemoglobin A, where the environment of the iron of all four chains is nearly tetragonal. This difference in heme symmetry suggests that the maintenance of tetragonal symmetry in the hemoglobin tetramer must be brought about by the configuration the alpha chains assume due to their contact with the beta chains. When isolated from the tetramer, some parts of the alpha chain must undergo physical displacement from a configuration that had been stabilized by the beta chains.Although differences in symmetry between monomer and tetramer are seen with high-spin forms, no such difference exists with two low-spin ferric forms. Here the symmetries of iron are primarily governed by the immediate ligand environment of the iron and not by the state of association of the protein.


Metabolism in vitro of (4-14C) testosterone by liver homogenates of normal and carbon tetrachloride injured rats.


Immunological studies on the membrane systems of cancer cells. 3. Immunospecificities of the mitochondria from virus-induced tumors by the precipitin reaction in agar gel.


Cytochrome oxidase in a cytochrome oxidaserich submitochondrial membrane.


Fractionation of proteins from perchloric acid filtrates of human sera and of its ethanol fractions by chromatography on DEAE-cellulose.


Mitral regurgitation in muscular subaortic stenosis.


Ultrastructural study of epidermodysplasia verruciformis Lewandowsky and Lutz. Demonstrations of the virus and its correlation with clinical changes.


Substrate specificity of adenyl cyclase from rat fat cell ghosts.


EPR studies on reduction of oxygen to superoxide by some biochemical systems.


The mechanism by which leucine and arginine stimulate insulin release in vitro.


Subcellular distribution of two enzyme systems which degrade 3'-phosphoadenosine 5'-phosphosulfate ("active sulfate").


Relationship of phagocytic activity to pathogenicity of mouse hepatitis virus as affected by triolein and cortisone.


Rhinovirus infection of vervet monkeys. A model of human rhinovirus disease.


Osteogenesis imperfecta: effect of magnesium administration on pyrophosphate metabolism.


A spin-labeled lipid for probing biological membranes.


Glucose and galactose transport across a water-butanol-phospholipid interface.


The intra-mitochondrial localization of flavoproteins previously assigned to the respiratory chain.


A new sulfinic amino acid: homohypotaureine (3-aminopropanesulfinic acid). Isolation, determination and chromatographic behaviour compared with sulfinic and sulfonic derivatives of cysteine and homocysteine.


Electron histochemical study of 1:2-glycol groups in experimental hamster amyloid.


Periodate oxidation of acid polysaccharides. II. Rates of oxidation of uronic acids in polyuronides and acid mucopolysaccharides.


Production of free radicals in reduced glutathione and penicillamine by thermal hydrogen atoms and X-radiation.


Influence of method of infection on the pathogenesis of infectious laryngotracheitis.


Pathogenesis of bovine parainfluenza 3 virus infection in organ cultures.


Primary liver tumours of cattle in Ceylon.


A standardized serum neutralization test for feline viral rhinotracheitis. I. Virus assay.


A standardized serum neutralization test for feline viral rhinotracheitis. II. The virus-serum system.


Various antibody holding status against viruses in Cercopithecus aethiops and Macaca irus. 3. The presence of antibodies to coxsackie, rubella, Japanese encephalitis, influenza and parainfluenza viruses.


Some effects of pH and temperature upon normal human red cell adenosine triphosphate.


Intestinal calcium absorption: nature of defect in chronic renal disease. When compared to that of normal animals, calcium-binding protein activity of duodenal mucosa obtained from uremic rats was decreased. There was no change in this activity after vitamin D(3), therapy. In contrast, prior treatment with 25-hydroxycholecalcijerol resulted in increased transport of calcium-45 and calcium-binding protein activity in the intestine.


Herpes simplex virus: dry mass.

Herpes simplex virus: dry mass. Dry mass of herpes simplex virus particles was measured by quantitative electron microscopy after isolation by surface spreading and critical-point drying of infected cells. The core weighed about 2 x 10(-16) gram, the empty naked capsid 5 x 10(-16) gram, the full naked capsid 7 x 10(-16) gram, and the enveloped nucleocapsid 13 x 10(-16) gram.


Picture of the month. Focal dermal hypoplasia (Goltz's syndrome).


Ultrastructural observations on epidermal cells in Paget's disease of the breast.


A role of the central nervous system in the cardiovascular actions of nicotine.


Potentiation by desmethylimipramine of ganglionic inhibition by catecholamines.


Enhanced release of transmitter during sympathetic nerve stimulation in the presence of angiotensin.


Inhibition of angiotensin pressor responses with diethyl-dithiocarbamate (DDC).


Release from brain tissue of compounds with possible transmitter function: interaction of drugs with these substances.


Catechol and indole derivatives in a transplantable islet-cell tumour of the golden hamster.


The effect of theophylline on sodium transport across frog-skin in the absence of chloride.


The mechanism of potentiation of inotropic responses to phenylephrine by theophylline.


Effects of cyclic 3',5'-AMP and other adenine nucleotides on the melanophores of the lizard (Anolis carolinensis). 1. Cyclic 3',5'-AMP has been reported to darken skins of the frog, Rana pipiens. This suggests that cyclic 3',5'-AMP may mediate the action of MSH on amphibian chromatophores. Since MSH also darkens skins of the lizard, Anolis carolinensis, we investigated the effects of cyclic 3',5'-AMP and other nucleotides on Anolis melanophores to determine whether cyclic 3',5'-AMP may be the intracellular mediator of hormone action on melanophores of another vertebrate class.2. Cyclic 3',5'-AMP, itself, causes a rapid melanin granule aggregation within melanophores of Anolis. This response is, however, somewhat nonspecific in that both 5'-ATP and 5'-ADP also lighten the skins by aggregating the melanin granules. Another nucleotide, 5'-AMP, darkens the skins by dispersing melanin granules. Cyclic 2',3'-AMP does not darken or lighten Anolis skins.3. Dibutyryl cyclic 3',5'-AMP, which is considered to be better able to penetrate membranes and resist degradation by a specific phosphodiesterase, maximally darkens Anolis skins, as does MSH. This darkening by the potent dibutyryl cyclic 3',5'-AMP suggests that cyclic 3',5'-AMP may be the intracellular mediator of melanin granule dispersion within Anolis melanophores leading to skin darkening.4. Other evidence supporting the first-messenger-second-messenger hypothesis for melanophore regulation is discussed.5. The differences in responses of Anolis melanophores to adenine nucleotides may relate to the ability of these agents to penetrate melanophore membranes; thus, the nucleotides could exert their effects either intracellularly or extracellularly on the plasma membrane.


The effects of hyoscine and anticholinesterases on cholinergic transmission to the smooth muscle cells of the avian gizzard. 1. Intracellular recordings were made from smooth muscle cells of the pigeon and chick gizzards. Hyoscine (10(-6) g/ml.) blocked, within 2 min, the excitatory junction potentials (E.J.P.s) evoked by transmural stimulation. As the amplitudes of E.J.P.s decreased, their durations also decreased. Hyoscine had no effect on the inhibitory junction potentials (I.J.P.s) evoked by transmural stimulation.2. Initially, physostigmine or neostigmine (10(-7) - 5 x 10(-6) g/ml.) caused a marked increase in the amplitudes of E.J.P.s, without affecting their time courses. Sometimes, anticholinesterases caused a single stimulus to evoke multiple E.J.P.s.3. After several minutes in the presence of high concentrations (10(-6) - 5 x 10(-6) g/ml.) of anticholinesterases the muscle cells were depolarized by about 15-20 mV, and thus the amplitudes of I.J.P.s evoked by transmural stimulation were larger than under control conditions. E.J.P.s summed at much lower stimulation frequencies than normal, an observation which indicated that high concentrations of anticholinesterases increased the durations of the E.J.P.s. Repetitive stimulation evoked a membrane depolarization which persisted for as long as 10 sec after stimulation was stopped.4. These results are discussed in terms of the action of the drugs at the nervesmooth muscle junction and on ganglion cells in the myenteric plexus.


Automatic determination of lactic acid in blood.


An azomethine-hypophosphorous acid addition compound as a new colorimetric reagent for iron.


The effect of flavin coenzymes on the activity of erythrocyte enzymes.


Choline esterase activity in the nervous system and the innervated organs of the scorpion, Heterometrus fulvipes.


Increased primary immune response and priming in mice to subimmunogenic doses of sheep erythrocytes by Bordetella pertussis.


Effect of nitrate esters of androgen steroids on the succinate oxidase and NADH-cytochrome c reductase activity of isolated rat liver mitochondria.


Generalized eruptive histiocytoma in a dog.


Cycloheximide-induced ultrastructural changes in the adrenal cortex of the rat.


Studies on the primary structure of ribosomal 28 S ribonucleic acid and its nucleolar precursors. Isolation of an electrophoretically homogeneous fragment rich in guanylic and cytidylic acids.


Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast.


Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit.


Lipid composition of rat liver plasma membranes.


Hydrolysis of guanosine 5'-triphosphate associated wh binding of aminoacyl transfer ribonucleic acid to ribosomes.


Independent smulation of secretion and protein snthesis in rat parotid gland. The influence of epinephrine and dibutyryl cyclic adenosine 3',5'-monophosphate.


Mass spectrometric study on the mechanism of D-glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase.


Control of gluconeogenesis from amino acids in the perfused rat liver.


Effects of glucagon on amino acid transport and utilization in the perfused rat liver.


A new spin label specific for the active site of serine enzymes.


The presence of tightly bound copper in ribulose diphosphate carboxylase from spinach.


The treatment of neonatal Escherichia Coli meningitis. Case reports.


Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo.


Non-identity between pulmonary bradykininase and converting-enzyme activity.


Extrinsic nervous control of gastric motility. An experimental study in the cat.


Antigens induced by the mouse leukemia viruses.


Cardiopulmonary resuscitation. II.

Cardiopulmonary resuscitation. II.


Hidradenocarcinoma: report of a case.

Hidradenocarcinoma: report of a case.


Incidence of trophoblastic neoplasia in Iraq.


Vitamin D esters: non-specific storage form of vitamin D in the rat.


The scope of interanomeric glycosyl transfer reactions: hetero-dialdoside synthesis by enzymic glucosylation of D-galactose and D-mannose.


Peripheral neuropathy in a person sensitive to dynamite.


Theory of step-wise excitation in gastropod heart.


Antigenic relationship between SL-leukemia cells and other murine leukemia cells.


Chromosome abnormalities in patients with syndactyly. Chromosome studies on 105 patients with syndactyly included two trisomy-21 mongols, a chromatin-positive boy with 47, XXY, a chromatin-negative short girl with 45,X0 and a boy with a familial D/D translocation. Chromosome patterns were normal in the other cases which included three patients with acrocephalosyndactyly and one patient with oro-facial-digital syndrome.The incidence of chromosome abnormalies was greater than expected since syndactyly of the fingers is uncommon in the chromosome disorders.THIS INCIDENCE MAY BE RELATED TO THE INCREASED MATERNAL AGE (MEAN: 29.4 years) of the syndactyly group compared to maternal age (mean: 26.64 years) of the control group although, paradoxically, four mothers of the five patients with chromosome abnormalities were young.


The use of postal questionnaires in a service context.


New antigens in cells transformed by the SV40 virus. II. Evidence of their cytoplasmic localization in a cell line (TSV5 CL2) of hamster fibroblasts transformed by SV40.


Prevention of carcinogenesis by murine sarcoma virus (Harvey) following injections of immune sera during the latent period.


Biological activity and separation of a leukaemogenic virus from murine sarcoma virus-Harvey (MSV-H).


Angiographic and histologic studies of the vascularization of peripheral nerve tumors.


The inhibition by cytosine arabinoside of the replication of murine leukemia and sarcoma viruses in mouse embryo cultures.


Rous sarcoma virus production in mixed cultures of mammalian Rous sarcoma cells and chick embryo cells.


The formation of variants with a reversion of properties of transformed cells. 3. Reversion of the structure of the cell surface membrane.


Murine sarcoma virus: titration patterns and interference by a murine leukemia virus.


Studies on plasma membranes. IX. A survey of enzyme activities displayed by plasma membranes isolated from normal and preneoplastic livers and primary and transplanted hepatomas of the rat.


Studies on plasma membranes. X. A survey of enzyme activities displayed by plasma membranes isolated from mouse liver and three mouse hepatoma strains.


Assay of polyoma virus infectivity by haemagglutinin induction.


The analysis of body water compartments in postoperative craniotomy patients. 3. The effects of dexamethasone.


Infections of the central nervous system due to pseudomonas aeruginosa.


Scaling and refractoriness in pulse trains.


Renal allotransplantation for bilateral renal tumors.


Histochemical studies of small and large bowels. 2. Histological and histochemical changes of human small intestine in various pathological states (results of intestinal biopsies in 102 cases).


Histochemical studies of small and large bowels. 1. Some enzymatic activities of normal human and laboratory animals.


The blood vessel permeability of peripheral nerve during primary demyelination and the effect of A.C.T.H. therapy on the permeability and on the functional disability.


Outside time and inside time.

Outside time and inside time.


Post-vaccinial sensory polyneuropathy with myoclonus.


Pharmacology of synaptic monoamine transmission.


Sleep, natural and unnatural.

Sleep, natural and unnatural.


A progress report on aftercare.

A progress report on aftercare.


Tumours of the chemoreceptor system.

Tumours of the chemoreceptor system.


Diagnosis of herpes virus hominis keratitis by immunofluorescence.


Platelet aggregation. II. Adenyl cyclase, prostaglandin E1, and calcium. In exploration of the proposal that prostaglandin E1 (PGE1) inhibits platelet aggregation via stimulation of adenyl cyclase, the temporal relationship of adenosine cyclic 3',5' monophosphate (cyclic AMP) synthesis and inhibition of ADP-induced aggregation in response to PGE1 was studied.  The requirement for calcium in aggregation led to the investigation of the effects of calcium ions on platelet adenyl cyclase activity.  PGE1 stimulated the synthesis of cyclic AMP from adenosine-5'-triphosphate-8-14-C by platelet membrane fractions and also increased cyclic AMP synthesis in intact platelets previously incubated for 2 hours with adenosine-14-C.  The accumulation of cyclic AMP increased signficiantly at low concentrations of PGE1 and reached a maximum at about 1 mug.  Regardless of the inducing agent, calcium ions are an absolute requirement for the aggregation of platelets.


Application of electron spin resonance to the study of the structure of human serum lipoproteins.


3-Deoxy-D-gluco-octulosonic acid.

3-Deoxy-D-gluco-octulosonic acid.


Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain.


Electroencephalogram and rapid eye movements during free imagery and dream recall.


The complementary aspect in the relation between biological and psychodynamic psychiatry.


Carcinoma of the lung in Iceland. A summary and some reflections concerning more recent principles for diagnosis and treatment.


Chemodectoma of the lung.

Chemodectoma of the lung.


Immunological relationships of some oncogenic DNA viruses. II. Primary tumour inhibition studies.


Immunological relationships of some oncogenic DNA viruses. I. Transplantation immunity studies.


Lipids of ocular tissues. I. The phospholipids of mature rabbit and bovine lens.


Phospholipids in tissues of the eye. 3. Composition and metabolism of phospholipids in human lens in relation to age and cataract formation.


Diether phosphinate lecithin: chemical synthesis and effects on phospholipase C.


Carbohydrate components of bovine-kidney gangliosides.


Heterogeneity of lipid composition of microsome subfractions from aorta and liver.


The effect of polypeptide hormones on lipid monolayers.  ii. The effect of insulin analogues, vasopressin, oxytocin, thyrocalcitonin, adrenocorticotropin, and 3',5'-cyclic AMP on the uptake of Ca2+ by monomolecular films of monooctadecyl phosphate.


Mechanism of the "antidiuretic hormone-like" action of hypertonic media on the frog urinary bladder.


Phosphate transport in Bacillus cereus.

Phosphate transport in Bacillus cereus.


Enrichment of 5'-nucleotidase in membrane fragments isolated from Acanthamoeba sp.


On the impermeability of the outer mitochondrial membrane to cytochrome c. I. Studies on whole mitochondria.


Evidence on the safety and efficacy of live poliomyelitis vaccines currently in use, with special reference to type 3 poliovirus.


Drug therapy of amoebiasis.

Drug therapy of amoebiasis.


Drug trials in amoebiasis.

Drug trials in amoebiasis.


A serological study of Cytomegalovirus infection in the population of Easter Island.


Long-lasting synaptic inhibition and its transmitter in the snail Helix aspersa.


Studies on heterologous antilymphocyte and antithymocyte sera. IV. Further evidence for a preferential effect on antigen-sensitive cells.


Role of ACTH in the secretion of free dehydroepiandrosterone and its sulfate ester in man.


Angiography of vascular lesions of the face and neck.


In vitro immune responses of rabbits with persistent adenovirus type 5 infection.


Pathogenesis of hypertension and implications for its therapeutic management.


Reaginic-type of antibody in mice stimulated by extracts of Bordetella pertussis.


Studies on the neutralization of Japanese encephalitis virus. II. Variations in reaction properties of virus to antibody during replication in PS cell cultures.


Varying specificity of systemic lupus erythematosus sera for histone fractions and a periodate-sensitive antigen associated with histone.


Ultrastructure of galactogen in the albumen gland of Helix pomatia.


Inhibition of herpes virus adsorption on cells by protamine.


Thermoinactivation of HF and M strains of herpes simplex virus in various conditions.


The use of the complement fixation test for indication of specific antigen in chicken embryo tissue cultures with the different sensitivity to Rous virus.


Antimicrobial susceptibility of enterobacteriaceae and nonfermenting gram-negative bacilli.


Peculiarities of complement fixation test in hamsters with sarcoma caused by various strains of Rous sarcoma virus.


Antigenic characteristics of tumors induced in Syrian hamsters by Simian virus 40.


Femoral neuropathy in scurvy.

Femoral neuropathy in scurvy.


Lung cancer in a mining district in Rhodesia.


Parasitological studies on liver abscess in Cheju Island.


The neoductuli in the rabbit liver with dietary, experimental icterogenic steatosis (Chisiu type). (Histochemical and histoenzymatic study).


Alveolar cell carcinoma. An electron microscopic study.


The relative role of recapture and of de novo synthesis for the maintenance of neurotransmitter homeostasis in noradrenergic nerves.


Postpartum amenorrhea-galactorrhea of hypothyroidism.


Extensive pseudomonal pneumonia ultimately responding to polymyxin therapy.


Fructose-1,6-diphosphatase of Acinetobacter: inhibition by ATP and citrate.


Pyrophosphate and diphosphonates in calcium metabolism and their possible role in renal failure.


Primary gene products of an arbovirus.

Primary gene products of an arbovirus.


Cyclic modes in neural net models.

Cyclic modes in neural net models.


Experimental applications of endoscopy.

Experimental applications of endoscopy.


The Zollinger-Ellison syndrome in a child. The Zollinger-Ellison syndrome was encountered in a boy aged 11 years who presented with a bulbar duodenal ulcer causing intractable pain and bleeding. The diagnosis was made by finding an overnight fasting gastric secretion of 1,300 ml containing 134 m-equiv/HCl, and little change of secretion after maximal histamine stimulus. A circumscribed non-beta islet cell pancreatic tumour was excised, with antrectomy. Postoperative acid secretion was normal and the boy was well after being followed up for 15 months. The diagnosis and management are discussed, as the view that total gastrectomy must be performed in all cases of the Zollinger-Ellison syndrome is questioned.


Rapid tests of adrenal cortical function using plasma 11-hydroxycortico-steroid determination.


"Activation" of vitamin D by the liver.

"Activation" of vitamin D by the liver. Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-(3)H vitamin D(3) into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D(3) (cholecalciferol) into 25-hydroxycholecalciferol. The osteodystrophy and the higher requirements for vitamin D observed in hepatic insufficiencies may be due to an inability of the liver to transform vitamin D into its metabolically active form.


Adenoid-cystic carcinoma of the larynx.

Adenoid-cystic carcinoma of the larynx.


Granular cell myoblastoma of laryngopharynx.


Yaba virus tumors.

Yaba virus tumors.


Cutaneous histiocytomas of dogs.

Cutaneous histiocytomas of dogs.


Some implications of sleep research for psychiatry.


Physical and chemical studies on ceruloplasmin: crystallization of desialized human ceruloplasmin asialoceruloplasmin. Completely or partially desialized human ceruloplasmin crystallizes as blue hexagonal prisms terminating at both ends in shallow pyramids.


Tumors of the chest wall.

Tumors of the chest wall.


Polymyxin Bduced respiratory paralysis reversed by intravenous calcium chloride.


Peripheral neuropathy in experimental coyotillo poisoning in goats.


Host specificity and pathogenicity of pox viruses from wild birds.


Sleep characteristics of patients with angina pectoris.


Structure of p-bromocarbobenzoxy-glycyl-prolyl-leucyl-glycine.


Hypophosphatasia: a case report.

Hypophosphatasia: a case report.


Dynamics of pyridine nucleotide in the placenta and the effect on it of sexagens.


Renal and splenic pituitary homograft to hypophysectomized rat during pregnancy and lactation.


Formation of hemichromes from oxidized hemoglobin subunits.


Diagnosis of non-depolarising block.

Diagnosis of non-depolarising block.


Reconstitutively active NADH dehydrogenase.


Localization of the atractyloside-sensitive nucleotide binding sites in rat liver mitochondria.


Studies on rat-liver phosphatases. I. Effect of acetoacetate.


Effect of ketone bodies and ACTH on the transmethylation reaction (S-adenosylmethionine dependent system) in rats. II.


Quantitative study on the transpulmonary passage of tumor cells.


Cytochemical studies on the second gradient axis of fertilized oyster eggs. V. On the activity of glucose-6-phosphatase, glucose-6-phosphate dehydrogenase and malate dehydrogenase and the relationship between egg nucleolus and egg periphery.


Specific gravity of liver cells during hepatocarcinogenesis by N-nitrosodiethylamine in rats.


Electron spin resonance study on the free radicals produced from carcinogenic aminonaphthols and N-hydroxy-aminonaphthalenes.


Malignant transformation of an established kidney cell line from African green monkey by the Schmidt-Ruppin strain of Rous sarcoma virus.


The localization of glucose-6-phosphate hydrolysing enzyme in hepatocytes, red blood cells and leukocytes in the liver of the newborn rat.


Electron microscopic studies of experimental viral hepatitis in mice. I. Virus Particles and their relationship to hepatocytes and kupffer cells.


Electron microscopic studies of experimental viral hepatitis in mice. II. Ultrastructural changes of hepatocytes associated with virus multiplication.


Determination of vitamin D in blood.

Determination of vitamin D in blood.


Follow-up study of nerve lesions in leprosy using the time intensity curve test.


Anti-lipolytic effects of beta-hydroxybutyrate.


Mechanism of action of antilipolytic agents: comparison of the effects of insulin, tolbutamide, and phenformin on lipolysis induced by dibutyryl cyclic AMP plus theophylline.


Central American leishmaniasis.

Central American leishmaniasis.


Leukaemia and cytomegalovirus infection.


Growth of vesicular stomatitis virus in Ehrlich ascites tumour cells. An electron microscopic study.


The effects of local x irradiation on the relative rates of incorporation of thymidine-methyl-5-3H and cytidine-5-3H into mitochondrial and nuclear DNA of Morris hepatoma 3924A.


Dose effects of chlorpromazine on human sleep.


Whole-lung irradiation for metastatic tumor.


Carinal resection, left pneumonectomy, and right lung anastomosis for adenocystic basal cell carcinoma (cylindroma).


Neuromuscular blocking activity of gentamicin in cats and mice.


Destruction and restoration of the insulin effector system of isolated fat cells.


Purification and properties of nascent f2 phage ribonucleic acid.


Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate.


Repression of beta-galactosidase synthesis by glucose in phosphotransferase mutants of Escherichia coli. Repression in the absence of glucose phosphorylation.


Two reduced nicotinamide adenine dinucleotide dehydrogenases from the photosynthetic bacterium, Rhodospirillum rubrum.


Azotobacter vinelandii ribonucleic acid polymerase. 8. Pyrophosphate exchange.


Interaction of coenzyme with differently prepared zinc-free (apo) horse liver alcohol dehydrogenases.


Purification and properties of two types of diphosphopyridine nucleotide-linked glycerol 3-phosphate dehydrogenases from chicken breast muscle and chicken liver.


Isolation of human hepatocuprein and cerebrocuprein. Their identity with erythrocuprein.


Studies on rates of abortive ternary complex formation of lactate dehydrogenase isozymes.


Reductive titrations of iron-sulfur proteins containing two to four iron atoms.


Monoxygenases. VII. Camphor ketolactonase I and the role of three protein components.


Fructose 1,6-diphosphatase from rabbit liver. XII. Effect of substrate and adenosine monophosphate on the ionization of the tyrosyl residues.


Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli.


The differential inactivation of histidinol dehydrogenase from Salmonella typhimurium by sulfhydryl reagents.


Differentiation of cross-reacting simian cytomegalovirus strains by late 19S rabbit neutralizing antibodies.


Surface antigens on interspecies hybrid cells.


The use of egg albumin conjugates for the purification of antibody.


The relation of changes in sodium transport to protein-bound disulfide and sulfhydryl groups in the toad bladder epithelium.


Norepinephrine turnover in brain and stress reactions in rats during paradoxical sleep deprivation.


Further observations on hepatic drug metabolism in rats treated with a mixture of somatotropin, corticotropin and prolactin.


Inhibition of estrogen-induced cyclic AMP elevation in rat uterus. II: By glucocorticoids.


The behavioral effects of nicotinamide adenine dinucleotide in chronic schizophrenia.


Longitudinal studies of the effect of monoamine oxidase inhibitors on sleep in man.


Feline rhinovirus: characterization of an isolate. (brief report).


The occurrence of virus particles in Rous hamster sarcoma.


Comparative electron microscopic study of Rous sarcoma in Syrian hamster and rat.


EEG effects of postoperative irradiation treatment of brain tumours.


The uptake of nucleosides by cells in culture. I. Inhibition by heterologous nucleosides.


An RNA fraction from myeloblastosis virus having properties similar to transfer RNA.


The uptake of nucleosides by cells in culture. II. Inhibition by 2-mercapto-1-(beta-4-pyridethyl)benzimidazole.


Deacylation of aminoacyl transfer RNA: comparison of enzyme preparations from different tissues of the rabbit.


Regulatory significance of transfer RNA charging levels. I. Measurements of charging levels in livers of chow-fed rats, fasting rats, and rats fed balanced or imbalanced mixtures of amino acids.


Effect of iron deficiency on nucleotide levels in Mycobacterium smegmatis.


Conduction velocity of optic nerve fibers innervating lateral geniculate body and superior colliculus in the rat.


Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. IV. Production of congenital and delayed swayback.


Isolation and biological properties of secretory granules from rat anterior pituitary glands. A method is described for the isolation of secretory granules from rat anterior pituitary glands. The method consists of differential and isopycnic gradient centrifugations, followed by filtration of the zones containing granules on Nuclepore filters to remove mitochondria. Highly purified granules were obtained as indicated by electron microscopy. Major parts of the thyrotropin (TSH) and adrenocorticotropin (ACTH) were recovered in a single fraction of granules as were follicle-stimulating (FSH) and luteinizing (LH) hormones. The somatotropin (STH) and prolactin (LTH) were recovered in separate granule fractions. The major parts of the six different hormones were associated with their respective granule fractions as shown by bioassays specific for each of the hormones. The diameters of granules in sections of intact rat pituitary glands and in isolated pellets were measured, and the means and ranges were in close agreement. These results contribute to the identification of the cell types which produce the different pituitary hormones.


Cellular pathology of calves experimentally infected with bovine herpes mammillitis virus.


Immunofluorescence studies of parainfluenza 3 virus in the lungs of lambs.


Foreign-body reaction in the liver of a drug addict.


Potential coenzyme inhibitors. 3. Some reactions of substituted nicotinamide and dihydronicotinamide derivatives.


Synthesis and activity of some N-substituted alpha-(2-n-hexyl-4,5-dimethoxyphenyl) ethylamines against Entamoeba histolytica.


Immunological responses to early and late intrauterine virus infections.


Subclinical central nervous system disease of neonates: a prospective study of infants born with increased levels of IgM.


Statistical measurement of signal transmission in the central nervous system of the crayfish.


Congenital cytomegalovirus infection: laboratory methods of detection.


A computer simulated model of a second order sensory neurone.


Pressor responsiveness to renin and angiotensin in renal hypertensive rats.


The care of patients with long-term illness after their discharge from hospital.


Liver-function tests in primary cancer of the liver in the Bantu.


Subcellular particles of human platelets. A biochemical and electron microscopic study with particular reference to the influence of fractionation techniques.


Oncogenicity of bovine papilloma virus.

Oncogenicity of bovine papilloma virus.


Factors in fusion of cells by HVJ.

Factors in fusion of cells by HVJ.


Conditional lethal mutants of animal viruses.


Modifying health-care services for schizophrenic patients.


Effect of aldosterone on angiotensin-induced glycosuria.


Studies on angiotensin-induced glycosuria.


Mechanism of angiotensin-induce glycosuria.


Tonic and phasic events during sleep: psychological correlates and implications.


The effect of reserpine and monoamine oxidase inhibitors on paradoxical sleep in the monkey.


Morphine effects on human REM state, waking state and NREM sleep.


Clinical and laboratory studies of ectopic humoral syndromes.


Psychosocial factors modifying host resistance to experimental infections.


Emotions and immunity.

Emotions and immunity.


Immunological parameters of the host-parasite relationship in neoplasia.


Sleep deprivation and EEG slow wave activity in chronic schizophrenia.


Activation in vitro of glucose-6-phosphatase, inorganic pyrophosphate-glucose phosphotransferase and related enzymes: relationship to microsomal membrane structure.


Molecular structure in phospholipid essential to activate (Na+ K+ Mg2+)-dependent ATPase and (K+ Mg2+)-dependent phosphatase of bovine cerebral cortex.


Gel filtration of marker enzymes of plasma membrane and endoplasmic reticulum from rat liver.


Alpha-adrenergic inhibition of Na+ transport: the interaction of vasopressin and 3',5'-AMP.


Reduced forms of the flavoprotein from egg-yolk.


Use of rabbit cornea continuous cell line for the diagnosis of infectious bovine rhinotracheitis and equine rhinopneumonitis infections.


Feline viruses. XI. Isolation of a virus similar to a myxovirus from cats in which urolithiasis was experimentally induced.


The tricarboxylic acid cycle and associated reactions in Moniezia expansa (Cestoda).


Platelet lipids (3). In vitro incorporation of 1-14C linoleic acid into lipid fractions of rabbit platelets.


Preparation, derivation and partial characterization of organ-specific antigens from human brain.


Susceptibility and resistance of various strains of Mycoplasma hyorhinis to antisera, polymyxins and low pH values.


Vascular responses of the spleen to rapid haemorrhage in the anaesthetized cat. 1. Splenic blood flow, splenic weight and arterial pressure were recorded in cats anaesthetized with sodium pentobarbitone. The mechanisms of the splenic contraction and vasoconstriction which followed rapid haemorrhage were investigated.2. When splenic arterial pressure was decreased progressively by mechanical occlusion of the coeliac artery, the decrease in splenic blood flow was proportional to the decrease in pressure; splenic weight did not change.3. After denervation of the spleen and adrenalectomy, haemorrhage resulted in a decrease in splenic flow which was similar to but slower than that in the innervated spleen; there was no splenic contraction. After splenic denervation, adrenalectomy and nephrectomy, haemorrhage caused a smaller decrease in flow but this response was still greater than that expected as a consequence of the reduced arterial pressure.4. Infusions of small doses of angiotensin caused splenic vasoconstriction with little change in splenic weight. Larger doses reduced both flow and weight.5. The splenic flow and weight responses to stimulation of the sympathetic nerves remained unimpaired when splenic blood flow was substantially reduced for 1-2 hr by haemorrhage.6. It is concluded that after a rapid haemorrhage, the splenic contraction is due only to activity of the splenic nerves and the adrenal medullae. The decrease in splenic flow is due to the reduction in arterial pressure, activity of the splenic nerves and the adrenal medullae, and the actions of angiotensin and some unidentified vasoconstrictor substance.


Transmission from vasoconstrictor and vasodilator nerves to single arterial smooth muscle cells.


Inhibitory post-synaptic potentials in the cerebral cortex.


Adenosine 3',5'-monophosphate (cyclic AMP) as the intracellular mediator of the action of secretin on the exocrine pancreas.


The iodide space in rabbit brain.

The iodide space in rabbit brain. 1. The iodide space in rabbit brain varies greatly depending on the conditions under which it is determined.2. When (131)I(-) only is used the iodide space 4 hr after administration of the marker is of the order of 2%. The iodide content of the cerebrospinal fluid (c.s.f.) is about 1% of that of the serum.3. Depression of the active iodide transport by perchlorate increases the space to 8.2% and the iodide content of the c.s.f. to 26% of that of the serum.4. The active iodide transport can also be depressed by saturation with unlabelled iodide. Up to a serum iodide concentration of 5 mM the space determined after 5 hr remained constant at 2.7%. The iodide space grew when the serum iodide content was enhanced from 5 to 20 mM, to become constant at a value of 10.6% on further increase of the serum iodide (up to 50 mM). The iodide content of the c.s.f. increased in a similar manner as the space with the iodide concentration of the serum to about 1/3 of the serum concentration. The iodide space of the muscle was independent of the plasma iodide content.5. From 4 to 8 hr after administration of (131)I(-) alone or with unlabelled iodide (to a serum concentration of 15 mM) the iodide space remained relatively constant.6. When (131)I(-) was administered in the fluid with which the ventricles were perfused an iodide space of about 7% was attained after about 5 hr.7. In experiments in which (131)I(-) was administered intravenously and the sink action of the c.s.f. was eliminated by perfusion of the ventricles with a perfusate containing as much (131)I(-) as the plasma, the iodide space was 10.2%. When in addition active iodide transport was depressed by perchlorate the space increased to 16.8%.8. Intravenous administration of labelled and unlabelled iodide (to a serum concentration of 20-40 mM) and ventricle perfusion with the same concentration of (131)I(-) and unlabelled iodide as in the plasma yielded an iodide space of 20.8%. In similar experiments the iodide concentration of the perfusate was so adjusted that after 5 hr perfusion its iodide content hardly changed during the passage through the ventricles. Under these conditions the iodide concentration of the extracellular and perfusion fluids can be considered to be near equal. The iodide space computed on the basis of the iodide content of the outflowing fluid was 22.5%.9. The large iodide space could be equated with the extracellular space if the iodide remained extracellular. This seems to be the case in the muscle where the iodide space is similar to the inulin space.10. The large effects on the iodide space of perchlorate and saturation with unlabelled iodide in experiments in which the marker was administered intravenously and in the perfusate (7 and 8) suggests the presence of an active iodide transport from the brain extracellular fluid into the blood over the blood-brain barrier.


Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones. 1. Monosynaptic excitatory post-synaptic potentials (EPSPs) produced in triceps surae motoneurones of the cat by stimulation of single afferent fibres in the muscle nerve were recorded with intracellular electrodes before and after the administration of thiopentone or pentobarbitone.2. The average amplitude of the ;unit' EPSP was 0.11-0.21 mV and remained unchanged after the administration of the barbiturates (10 mg/kg, I.V.).3. Mean quantum content (m) ranged from 1.9 to more than 5 before drug administration. The m was reduced by thiopentone (10 mg/kg, I.V.) and pentobarbitone (10 mg/kg, I.V.) by 23.1 and 24.7% respectively.4. The barbiturates, in the doses employed, produced no alterations in the input resistance of the motoneurone membrane or in the strength-duration relation obtained by passing depolarizing current pulses through the micro-electrode.5. It is concluded that the action of thiopentone and pentobarbitone, in the doses used, is confined to the presynaptic nerve terminals and results in a reduction in the amount of transmitter released by afferent impulses.


Alpha chloralose and nocturnal physiological patterns.


Pregnancy following treatment of mammary carcinoma.


Angiographic diagnosis of pancreatic disease.


Determination of phosphate and phosphomonoesterases in biologic materials.


A single-oven gas chromatograph with a simple, all-quartz, flame ionization detector.


Evaluation of electron spin resonance for quantitative determinations of gadolinium, chromium, iron, copper and manganese.


Effects of hypnotics on sleep patterns, dreaming, and mood state: Laboratory and home studies.


Sleep of the body.

Sleep of the body.


Effect of antidepressant drugs on sleeping and dreaming. 3. On the depressed patient.


The sleep rhythms of subcortical nuclei: some observatis in man.


Gas-chromatographic estimation of urinary vanillylmandelic acid after transformation to vanillin methoxime trimethylsilyl ether.


Effect of morphine on cholinergic receptors.


Studies on the effect of diazepam (Valium) on neuromuscular transmission in skeletal muscles.


Chemical composition of some bovine nephroliths with special reference to silica nephroliths.


Malignant head catarrah (?). A case report.


A comparison of two methods for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycorticosteroids in urine.


Experimental endogenous lipid pneumonia and silicosis.


Light- and electron-microscope studies on the granular cell myoblastoma of the tongue.


Aging of aortic smooth muscle cells in rats and rabbits. A morphologic and biochemical study.


The effect of portacaval transposition on radiation nephritis-induced hypertension in the dog.


Breast cancer after prophylactic subcutaneous mastectomies and reconstructionwith silastic prostheses.


Auriculotemporal syndrome (Frey's syndrome), secondary to fracture of the mandibular condyle.


Mouse leukemia virus activation by chemical carcinogens. The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.


Fine structure and biochemical properties of purified cytochrome oxidase.


Paralytic poliomyelitis in an unimmunized child. Apparent result of a vaccine-derived poliovirus.


Neonatal herpetic infection. Report of two premature infants treated with systemic use of idoxuridine.


Sino-aortic reflexes and arterial pH, PO2, and PCO2 in wakefulness and sleep.


Intrarenal blood flow and PAH extraction during angiotensin infusion.


Serotonin mediation of circadian periodicity of plasma 17-hydroxycorticosteroids.


Location of synaptic connections in canine sympathetic cardiac innervation.


Electrophysiological properties of Limulus heart and effect of drugs.


Release of infectious canine hepatitis virus.


Pathogenesis of canine herpesvirus in specific-pathogen-free dogs: 5- to 12-week-old pups.


Pathogenesis of bovine mamillitis virus infection in cattle.


Intratemporal facial palsy.

Intratemporal facial palsy.


The incorporation of p-hydroxybenzoic acid and isopentenyl pyrophphate into ubiquinone precursors by cell-free preparations of rat tissues.


Localization of glycosyl transferase activities in a Golgi apparatus-rich fraction isolated from rat liver.


On the phosphorescence of collagen.

On the phosphorescence of collagen.


Equilibrium and kinetic studies on the reversible dissociation of yeast enolase by neutral salts.


Isolation of 17-alpha-estradiol 17-beta-D-glucopyranoside from rabbit urine, and its synthesis and characterization.


Interactions of lipids with a membrane structural protein from myelin.


N6-(delta-2-isopentenyl) adenosine. Biosynthesis in transfer ribonucleic acid in vitro.


Dinitrophenylation and thiolysis in the reversible labeling of a cysteine residue associated with the nicotinamide-adenine dinucleotide site of rabbit muscle glyceraldehyde 3-phosphate dehydrogenase.


Studies on lysyl transfer ribonucleic acid synthetase from Escherichia coli.


Spin labeling of vitamin B 12.

Spin labeling of vitamin B 12.


The reaction of L-serine O-sulfate with aspartate aminotransferase.


Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation.


Structure of succinoglucan, and exocellular acidic polysaccharide of Alcaligenes faecalis var. myxogenes.


The significance of intermediary plateau regions in enzyme saturation curves.


Phosphorescence and energy transfer in enzymes.


Chromatography and radioimmunoassay of angiotensin II and metabolites in blood.


Electron spin resonance study on single crystals of haemoglobin M Kankakee.


Electron spin resonance study of the transition metal-binding site of concanavalin A.


Properties of hemoglobin M, Milwaukee-I variant and its unique characteristic.


Sclerosing injections for esophageal varices.


The effects of alpha amylase on collagen-proteoglycans and collagen-glycoprotein complexes in connective tissue matrices.


Effect of electrical stimulation of the medial mid-brain reticular formation and administration of ACTH on the plasma electrolytes.


Hereditary infections with mammary tumor viruses in mice.


Cardiovascular responses to hypertension and hypotension in dogs with denervated hearts.


Hepatoma and renal tubule adenoma in rats fed aflatoxin and cyclopropenoid fatty acids.


Pituitary mammotropic tumor in rats: evidence for a dosage effect on organ weight and liver drug metabolism.


High-yield isolation of mouse mammary tumor virus.


Antigenic and oncogenic properies of a cell line derived frm a hamster brain tumor induced by simian adenovirus 7.


An electron microscope study of glycogen formation in novikoff ascites-hepatoma cells.


Transient changes in EEG sleep patterns of married good sleepers: the effects of altering sleeping arrangement.


So-called Bartter's syndrome.

So-called Bartter's syndrome.


Pathogenesis of Bartter's syndrome.

Pathogenesis of Bartter's syndrome.


Dreams of subjects with loss of memory for recent events.


Community nursing services as perceived by posthospatalized patients.


Potentiation of venoconstriction by alpha,alpha'-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl dibromide, DMAE.


Pancreatic islet cell carcinoma with hyperinsulinism and probable, ectopic ACTH-MSH secretion.


The nature of the enzymically catalysed binding of glucose to the protein coat of Colpoda steinii cysts.


An automatic apparatus for the study of enzyme kinetics. A continuous-flow apparatus is described for automatically plotting substrate saturation curves, and is suitable for use with a variety of enzymes. A linear concentration gradient of the variable substrate is combined with a fixed proportion of the other substrates and the enzyme, and after passing through a reaction coil the product concentrations are measured spectrophotometrically. Use of a 4cm. flow cell and modified spectrophotometer permits accurate measurement of NADH concentration in the region of 0.1mum. Precise control over reaction times and substrate concentration is achieved by using power-driven syringes with an integral mixer. Specimen results are given for yeast alcohol dehydrogenase.


The enzymic hydroxylation of protocollagen models. 1. Synthetic polymers of l-prolyl-l-prolylglycine of defined chain length, (Pro-Pro-Gly)(n), were found to be substrates for the enzyme protocollagen-proline hydroxylase, with optimum chain length n=5. Boiling the polymer (Pro-Pro-Gly)(15) increased its activity as a substrate but had no effect on (Pro-Pro-Gly)(5). 2. Protection of both or one of the N- and C-terminal groups made (Pro-Pro-Gly)(3) a better substrate, and collagenase digestion of hydroxylated tert.-pentyloxy-carbonyl-(Pro-Pro-Gly)(3) benzyl ester indicated that the central prolyl residues were the major points of hydroxylation. 3. The results suggest that the long-chain peptides are optimum substrates but that a triple-stranded structure is inhibitory for hydroxylation.


Properties of the inactive ribosomal components in rat liver and hepatoma. 1. The relative concentrations of the inactive ribosomal components were compared in normal and regenerating rat liver and in two transplantable rat hepatomas (hepatomas 7800 and 5123D). 2. The size of the ribosomal-subunit pools in normal liver was not significantly affected by partial hepatectomy or neoplasia although, as shown previously, significant changes do occur in the monomer pool. 3. Further, the subunit pools in both liver and hepatoma were not significantly influenced by several treatments that caused dramatic changes in the size of the ribosomal monomer (and dimer) pools. 4. The high concentration of inactive monomers and dimers in the hepatomas appears to arise from limitations at the translational level, since they can be incorporated into pre-existing polyribosomes under the influence of cycloheximide.


Purification and characterization of bovine enteroviruses.


The regulation of L-asparaginase activity in rats and mice. Effects of normal and malignant growth, of sex and of dietary changes. 1. The activity of l-asparaginase was very low in the liver of newborn rats and mice, and increased within a few days of birth. 2. In rats, but not in mice, the enzyme activity was higher in females than in males, was enhanced by administration of oestradiol, and was decreased by gonadectomy. 3. The enzyme activity decreased in mice starved or fed on a low-protein diet; in rats it was enhanced by starvation, by feeding them on a high-protein diet, or by administration of l-asparagine. 4. The asparaginase activity was decreased in regenerating liver, and was almost absent in the Morris hepatoma 5123.


Composition of the phospholipid fraction of Corynebacterium diphtheriae.


Nucleotide sequences from specific areas of the 16S and 23S ribosomal RNAs of E. coli.


The effect of triiodothyronine on cyclic AMP, phosphorylase, and adenyl cyclase in rat heart.


Labeling of alpha-P of nucleoside triphosphates by in vivo incorporation of 32P in rat liver.


Age-correlated changes in lysosomal enzyme activities: an index of ageing?


Studies on lactic dehydrogenase in health and in diseases.


Cytogenetic and nuclear studies on A9 and B82 cells fused together by sendai virus: the early phase.


Primary aldosteronism in a hypertensive acromegalic patient.


Occurrence of a virilizing syndrome with 21-hydroxylase deficiency after pregnancy.


Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.


Vesicular stomatitis virus autointerference.


Comparison of chemically induced and virus-induced chromosome aberrations.


Effects of hydrocortisone on the metabolism of muscular lipids.


Studies on morphological precursors of the mouse hepatoma induced with o-aminoazotoluene. II. Sequence to the development of hepatoma and its gradation with strain SL mice.


Heterogeneous DNof simian virus 40.

Heterogeneous DNof simian virus 40.


Cell transformation by polyoma virus and SV40.


Vasopressin test in tumours of the sellar region.


The herpesvirion and its precursors made in productively and in abortively infected cells.


Cottonseed meal and tumors.

Cottonseed meal and tumors.


Advances in the treatment of respiratory disorders.


Advances in the treatment of endocrine disorders.


Enzyme histochemical studies of senile plaques and the plaque-like degeneration of arteries and capillaries (Scholz).


Study of dreams by using "REMP-awakening technique" psychophysiological study of dreams in normal subjects. 1.


Psychophysiological study on the dreams of chronic schizophrenics--studies on the dreams of psychotics. I.


Variations in REM dreaming and the effectiveness of behavior in group therapy.


Dreaming and nitrous oxide.

Dreaming and nitrous oxide.


Drug-induced changes in blood pressure as recorded by direct and indirect methods.


Fructose 1,6-diphosphatase from rabbit liver. 13. The number of Mn++ binding sites measured with 54Mn++.


Role of multiple binding sites in the inhibition of NADH oxidase by piericidin and rotenone.


The hydrolysis of phosphoenol pyruvate catalyzed by rabbit liver fructose-1,6-diphosphatase.


Inhibition by viomycin of cell-free protein synthesis in sensitive and resistant strains of Rhizobium meliloti.


Hyperparathyroidism associated with malignant tumors of nonparathyroid origin.


Paget's disease of the male breast.

Paget's disease of the male breast.


Enzyme histochemical study of primary hepatic carcinoma in Thailand.


Hepatoblastoma in infant sisters.

Hepatoblastoma in infant sisters.


Bronchiolar carcinoma: a valid clinicopathologic entity? A study of 30 cases.


Endolymphatic radiotherapy. A comparison of radiogold and radioiodine against the VX2 tumor in the rabbit.


Comparative ultrastructure of atypical ductal hyperplasia, intraductal carcinoma, and infiltrating ductal carcinoma of the breast.


Prognosis of breast cancer based on pathologic type.


Early phases in the development of breast cancer.


Breast xeroradiography.

Breast xeroradiography.


Viruses as possible etiologic factors in human breast cancer.


Studies of human milk in relation to the possible viral etiology of breast cancer.


A new approach to mammary tumorigenesis in rodents.


Mammary carcinoma. A discussion of therapeutic methods.


The effect of density-delayed pupation on cytochrome oxidase activity in Drosophila melanogaster.


Histochemical study of oxidative and hydrolytic enzymes in the abnormal human parathyroid.


Ataxia-telangiectasia with gastric adenocarcinoma.


Morphological studies on the peripheral small arteries of spontaneously hypertensive rats.


Hyperbaric oxygen in gas gangrene.

Hyperbaric oxygen in gas gangrene.


The function of the adrenal glands during prolonged corticosteroid therapy.


A study of the effect of corticotrophin on skeletal maturation and linear growth on six patients with severe asthma.


The effects of corticosteroid and ACTH therapy on growth and on the hypothalamic-pituitary adrenal axis of children.


Physiology of the adrenal cortex in childhood.


Fine structure of smooth muscle and neuromuscular junctions in the foot of Helix aspersa.


Treatment of acute ischemic pain in the leg by induced hypertension.