Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru. Endemic goiter is a health problem in many areas of the world; in some areas the disease is so severe that cretinism and other defects are found.  In many areas geographic, economic, and other factors prevent the use of iodized salt as a preventive measure.  Field studies were begun in 1966 to determine the feasibility and effectiveness of parenteral administration of iodized oil in goiter prevention.  Studies were carried out in Ecuador and Peru.  In Ecuador 2 villages were chosen in which the prevalence of goiter was about 60%; in Peru 3 villages were chosen where incidence was about 50%.  Prevalence of goiter decreased for 20 months during the study but then began to rise again with the maximum reduction seen up to age 18 and minimal reduction after 40 years of age.  The control groups in the study experienced only slight decreases in rate of incidence.  Cretinism has not yet appeared among the progeny of the population injected with iodized oil but several instances have appeared in control groups.  The use of iodized oil as a public health procedure for the prevention of endemic goiter and its associated defects is an acceptable measure in regions where salt iodization cannot be done.


Retention of differentiated function in clonal animal cell lines, particularly hormone-secreting cultures.


Isolation and partial characterization of beef heart proteolipid.


Lipid-iodine association in the rat thyroid gland.


Vincristine sulfate and radiation therapy in metastatic Wilms' tumor.


Wilms' tumor in an adult.

Wilms' tumor in an adult.


Ultrastructure of adenoid cystic carcinoma.


Radiation-induced skin cancer of the head and neck.


Hemorrhagic cystitis and cytomegalic inclusions in the bladder associated with cyclophosphamide therapy.


Intracellular recording in extensor motoneurons of spastic cats.


Characteristics of the reaction between diphtheria toxin, pyridine coenzymes and the GTP-splitting transfer factor FI.


The use of synthetic substrates for the determination of mammalian collagenases. Is collagenolytic activity present in mitochondria?


Carbohydrate metabolism in experimental Bacillus Calmette-Guerin infection.


Inhibition of tumor growth by nucleoside cyclic 3'-5'-monophosphates.


The molecular structure of SV40 virions.


Internal components of adenovirus.

Internal components of adenovirus.


Multiple forms of D (-)3-hydroxybutyrate dehydrogenase in Rhizobium.


Fate of adenovirus during the early phase of infection.


Egg production and disease: adenovirus.

Egg production and disease: adenovirus.


Comparison of two canine adenoviruses.

Comparison of two canine adenoviruses.


Behaviour of some enzymes of the cell envelope of baker's yeast during the digestion of the cell wall.


Studies on the nuclear 4 to 7 s RNA of the Novikoff hepatoma.


Absolute barrier isolation and antibiotics in the treatment of experimental burn wound sepsis.


The combined otolaryngology-neurosurgery approach to extensive benign tumors.


Influence of contralateral noise stimulation on tone decay and SISI tests.


Rubella-like bone changes in congenital cytomegalic inclusion disease.


Body distribution of intralymphatically injected radioactive colloid and oil.


The spectrum of angiographic findings in hepatoma.


Tubular effect of angiotensin II on the toad kidney.


The action of chlorpromazine on the neuromuscular junction.


Immunologic response to cytomegalovirus infection in renal allograft recipients.


Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome.


Comparison of protective effect of neutralizing antibody in serum and nasal secretions in experimental rhinovirus type 13 illness.


An improved procedure for preparation of inner membrane vesicles from rat liver mitochondria by treatment with digitonin.


Metastatic mucinous adenocarcinoma of the eye.


Studies on the nucleotide specificity of mitochondrial inner membrane particles.


Structural analyses of rat liver phosphoglycerides.


Glycine metabolism by rat liver mitochondria. IV. Isolation and characterization of hydrogen carrier protein, an essential factor for glycine metabolism.


Ultrastructural and conformational changes in gas vacuole membranes isolated from Microcystis aeruginosa.


The hydrolysis of estrone sulfate by rat kidney microsomal sulfatase.


Terpene biosynthesis: utilization of neryl pyrophosphate by an enzyme system from Pinus radiata seedlings.


Spectroscopy and structure of hemerythrin.


UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum.


Postabortal anuria due to clostridial infection.


The importance of the renin angiotensin system in hypertension due to coarctation of the aorta.


Morphochemical analysis of mucous cells in the skin and slime glands of hagfishes.


A note on the use of p-fluorophenylhydrazine for the cytochemical demonstration of periodate-reactive mucosaccharides and polysaccharides in the electron microscope.


Localization of acetylcholinesterase in the rat myoneural junction.


Histochemical studies on the enzymes of glycogen metabolism in hamster epididymis.


The role of the renin-angiotensin system in the control of aldosterone secretion.


The role of the renin-angiotensin system in the control of aldosterone in man.


Studies on the loci of action of stimuli to the biogenesis of aldosterone.


Cardiovascular reflexes and the control of aldosterone production and sodium excretion.


Decreased incidences of resistance to antimicrobial agents among Escherichia coli and Klebsiella-enterobacter. Observations in a university hospital over a 10-year period.


Suppressed plasma renin activity in essential hypertension. Roles of plasma volume, blood pressure, and sympathetic nervous system.


Isolation of a RNA-dependent RNA polymerase from virus infected myeloblasts.


Further cytophysiologic evidence for the dentity of the cells that produce adrenocorticotrophic hormone.


Production of steroids by in vitro superfusion of endocrine tissue. 3. Corticosterone output from rat adrenals stimulated by adrenocorticotropin or cyclic 3',5'-adenosine monophosphate and the inhibitory effect of cycloheximide.


Parathyroid hormone-sensitive adenyl cyclase in isolated renal tubules.


Pituitary-adrenal function in the squirrel monkey.


Functional relationship between the pars intermedia and ACTH secretion in the rat.


Effect of selective surgical interruption of the anterior pituitary's blood supply on ACTH release.


Effect of ACTH on enzymatic defect produced in vivo by a competitive inhibitor of 3-beta-hydroxysteroid dehydrogenase.


Clofibrate inhibits lipid synthesis and ACTH-stimulated steroidogenesis by rat adrenal tissue.


Specific retention of an inhibitor of 3-beta-hydroxysteroid dehydrogenase in enzyme-containing tissues of the rat.


Composite restorative resins. Council on Dental Materials and Devices.


Cytology and growth characteristics of human tumour astrocytes transformed by Rous sarcoma virus.


Stimulation of insulin and growth hormone secretion by adenine nucleotides in primates.


Synovial sarcoma of the hand.

Synovial sarcoma of the hand.


Hypophosphatasia. Histopathology of human temporal bones.


Replicating molecules of polyoma virus DNA.


End-vessel reactivity and capillary clearance in diabetes mellitus.


Viral synthesis after simultaneous infection with guanidine-sensitive and guanidine-dependent polioviruses.


Explant culture of rat liver. I. Method, morphology, and cytogenesis.


Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme.


On being a patient.

On being a patient.


Adenyl cyclase activity in isolated fat cells from cold exposed rats.


Psychiatric nursing: challenge of the future.


Herpes simplex hepatitis in an adult. A case report with virological and electron microscopical examination at autopsy.


The adrenocorticotropic effect of D-serine-1-norleucine-4-valinamide-25-beta-1-25-corticotropin (DW 75). A comparison with genuine ACTH.


Oxidative enzymes in milk and their value as indicators of sub-clinical mastitis in the cow.


Functions of the adenohypophysis: special position of thyrotrophic function.


Relevance of sodium transport pool measurements in toad bladder tissue for the elucidation of the mechanism whereby hormones stimulate active sodium transport.


The effect of angiotensin on isolated rabbit renal tubules.


The cardiovascular response to vertebral artery infusions of angiotensin in the dog.


Efferent pathways of the cardiovascular response to vertebral artery infusions of angiotensin in the dog.


Response of kidney and salivary gland G-6-PD and renin to adrenalectomy, angiotensin, bradykinin and meralluride.


Alterations in carbohydrate metabolism in Jamaican children with severe malnutrition.


Interrelationship between salvage pathway and synthesis de novo of adenine nucleotides in kidney slices.


Blood circulation in the intestine of the cat under halothane anaesthesia.


Enzyme histochemistry of the bovine ovaries in normal and cystic conditions.


Electron microscopic studies concerning the structural mechanism of the development of mental disturbance in experimental chronic methamphetamine poisoning.


Manifest dream content in normal and psychopathologic states.


Acute parotitis associated with parainfluenza 3 virus infection.


The localization of plmitoyl-CoA: carnitine palmitoyl-transferase in rat liver.


Studies on the mechanism of inhibitionof the mitochondrial electron transport by antimycin. II. Antimycin as an allosteric inhibitor.


Inhibition of photosynthesis in isolated spinach chloroplasts by added fructose-1,6-diphosphatase.


Succinate dehydrogenase. II. The effect of phospholipases on particulate and soluble succinate dehydrogenase.


An extractable collagenase from crustacean hepatopancreas.


The subcellular localization of alcohol dehydrogenase activity in baker's yeast.


Phosphotransacetylase of Escherichia coli B, activation by pyruvate and inhibition by NADH and certain nucleotides.


The zinc requirement of dinucleotide pyrophosphatase in mammalian organs.


Effects of cetyltrimethylammonium bromide on catalytic properties of kidney microsomal glucose-6-phosphatase, inorganic pyrophosphate-glucose phosphotransferase and inorganic pyrophosphatase activities.


Purification and properties of a ribonuclease from Avena leaf tissues.


Purification and properties of endopeptidase from rabbit red cells and its process of degradation of angiotensin.


Relationship of L-alanine and L-glutamate dehydrogenases of Bacillus thuringienses.


NAD-specific isocitrate dehydrogenase from a plant source. Sigmoid kinetics and enzyme stability.


Detection of guanyl cyclase in mammalian tissues.


Inhibition of adenine phosphoriboxyltransferase by pyrophosphate.


Acid and alkaline ribonucleases of plasma.


Electron paramagnetic resonance spectra of amine oxidase from Aspergillus niger.


Observations on the reflex response to muscle vibration in man and its voluntary control.


(Mg2+ Na+ K+)-ATPase activity of liver from tumor bearing rats.


The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.


Lactic dehydrogenase isozyme distributions in various cell types of the mammalian liver.


Fractionation of DNA on columns of poly-L-lysine supported on kieselguhr.


Cation transport. I. Metabolic activity of the polyphosphoinositide complex in isolated renal cortex tubules.


Adenoviral pneumonia and its complications in infancy and childhood.


Unilateral hyperlucent lung: a complication of viral pneumonia.


Iodoventriculography in hydromyelia.

Iodoventriculography in hydromyelia.


Renal arteriography in the pediatric age group.


Current treatment of Wilms tumor.

Current treatment of Wilms tumor.


The autonomic innervation of human submandibular and parotid glands.


Hepatocancerogenesis in mice with the simutaneous administration of diethylnitrosamine and the virus Motol.


Erythroblastosis and erythroblastic leukemia in rats induced by material from chick erythroblastosis.


Investigations on the transformation of fibroadenoma of the breast into malignant cystosarcoma phyllodes.


The acute effects of reserpine on the sleep-wakefulness cycle in rabbits.


The role of the hospital laboratory in the diagnosis of viral diseases. I. Basic concepts.


Intestinal parasites.

Intestinal parasites.


Adverse cutaneous reaction to oral contraceptives.


Reversible dissociation of tetrameric rabbit muscle glyceraldehyde 3-phosphate dehydrogenase into dimers or monomers by adenosine triphosphate.


Primary liver-cell carcinoma in a young thoroughbred horse.


A review of the literature: collagen: its physical characteristics and degradation.


The nurse migrates.

The nurse migrates.


Utilization--a vehicle for the effective delivery of patient care services.


Fair and pleasing medicines.

Fair and pleasing medicines.


A case of homologous liver transplantation.


The differential diagnosis of benign cholangioma and liver metastases.


Effects of thyrotropin, sodium fluoride and ions on thyroid slice metabolism.


Studies on phenolic steroids in human subjects. 13. A rapid assay of urinary estrogen conjugates in pregnancy.


Wilms' tumor: the evolution of a treatment program.


Electron paramagnetic resonance study of free radical products of the reaction of ninhydrin with amino acids, peptides and proteins.


Circular dichroism of proteins of known and unknown conformations.


Pyrophosphate enhancement of thyrocalcitonin effect in tissue culture.


Modification of the indirect haemagglutination test for amoebiasis. Optimal conditions for carrying out the indirect haemagglutination test with sheep erythrocytes were studied using the microtitre system. The age of the erythrocytes, concentration of reagents, time and temperature of tanning, sensitization, and incubation are described with reference to replication of titres. Sera from patients with amoebic colitis were used to evaluate the test conditions.


Chemodectoma of the orbit.

Chemodectoma of the orbit. The histological and clinical features of a primary chemodectoma arising in the orbit are described. It is suggested that the tumour may have arisen from chemoreceptor tissue in the area of the lacrimal gland.


Plasma "cortisol" levels in right and left ventricular failure. Plasma ;cortisol' values are reported in 36 patients during or following right ventricular failure, and 12 during or following left ventricular failure. In patients with right ventricular failure the normal circadian rhythm was abolished with elevation of midnight values. Disturbance of rhythm was less marked in left ventricular failure, although midnight values were usually raised. Dexamethasone suppression of plasma ;cortisol' levels was abolished or reduced in right ventricular failure. These results confirm our earlier findings and further support our contention that the disturbance of circadian rhythm is not due to a simple stress mechanism. The results are of importance in the differential diagnosis of Cushing's syndrome based on plasma ;cortisol' values, if there is concomitant right ventricular failure.


Studies on the susceptibility of organ cultures to infection and on the localization of the virus in the cultures.


Binding of antibiotics to tissue homogenates.


Electrical properties and synaptic connections of the sympathetic neurons in the rat and guinea-pig superior cervical ganglion.


Cortical unit activity in desynchronized sleep. Bursts of unit firing associated with surface positive electroencephalogram waves and rapid eye movements account for the mean increase in discharge rate in desynchronized sleep over that of the synchronized phase. Firing rate begins to change toward the value it will assume in desynchronized sleep in the minute before the usual electrographic criteria of desynchronized sleep are present.


Biochemical changes in the interscapular brown adipose tissue of rats during the cold acclimation process. Effect of ionizing radiation on growth of brown fat. ANL-7409.


The distribution of mitochondrial enzymes in rat liver after various treatments, in liver from other species, and in rat heart. ANL-7409.


Induction of ultrastructural lesions in rat adrenal cortex by 3-acetylpyridine. ANL-7409.


Cardiovascular responses of the cat to mesenteric intra-arterial administration of nicotine, cyanide and venous blood.


Saphenous nerve conduction in man.

Saphenous nerve conduction in man.


Methods of tendon jerk reinforcement. The role of muscle activity in reflex excitability.


The effect of local pressure in diphtheritic neuropathy.


Compartmental redistribution of 99mTc-pertechnetate in the presence of perchlorate ion and its relation to plasma protein binding.


Serum electrolyte abnormalities associated with the administration of polymyxin B in febrile leukemic patients.


Carbon monoxide intoxication with peripheral neuropathy.


Increase of cytochromes a and a3 in rat kidney mitochondria in response to administration of aldosterone in vivo.


Heart tone.

Heart tone.


Endobronchial granular cell myoblastoma. A report of three cases and review of the literature.


Congenital and neonatal anomalies linked with viral infections in experimental animals.


A histochemical and electron microscopic study of Gaucher cells.


The pancreatic beta cell. Demonstration with peroxidase-labeled antibody technique.


The effect of ethyl alcohol on inferred visual dreaming.


Histochemical comparison of the effects of a carcinogenic and a non-carcinogenic derivative of tricycloquinazoline.


Antidepressant drugs and sleep.

Antidepressant drugs and sleep.


LSD and the sleep-dream cycle.

LSD and the sleep-dream cycle.


A fourth dimension of consciousness.

A fourth dimension of consciousness.


Dreams in narcolepsy, hypersomnia and dissociated sleep disorders.


Telepathy and dreams.

Telepathy and dreams.


Peripheral hormonal and metabolic correlates of rapid eye movement sleep.


Drugs and dreams, a synthesis.

Drugs and dreams, a synthesis.


The effects of drugs on the EEG sleep patterns of normal humans.


Sleep.

Sleep.


Modification of subsequent intracerebral infection with Bordetella pertussis by previous local brain irradiation.


Fast and slow mammalian muscles after denervation.


Separation of conjugated urinary estrogens on columns of sephadex. II. Sequential separations.


Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. II. Effects of fatty acids and albumin on respiration. Fatty acids inhibited the ability of Escherichia coli membrane-envelope fragments to catalyze the oxidation of succinate and nicotinamide adenine dinucleotide, reduced form (NADH) and also inhibited the response of the Clark oxygen electrode to nonenzymatic oxygen uptake. In all cases, unsaturated fatty acids were much more inhibitory than saturated fatty acids. Albumin afforded complete protection from inhibition in the nonenzymatic oxygen-uptake experiments but only partial protection for the respiratory activities of the membrane fragments. The succinoxidase activity was totally inhibited by bovine serum albumin at concentrations that inhibited succinate dehydrogenase only slightly and NADH oxidase not at all. The E. coli acellular preparation showed no dehydrogenase or oxidase activity for any of the fatty acids under a variety of conditions. These conditions included variations of pH, concentration of fatty acids, and the presence or absence of albumin, CoA, ATP, NAD, cysteine, succinate, and carnitine. It thus appears that E. coli grown in the absence of fatty acid can not use fatty acids as an energy source.


The structure of viruses of the papilloma-polyoma type. V. Tubular variants built of pentamers.


Nuclear fragmentations and associated fibrils in giant cell tumor of bone.


Studies on the bacteriophage MS2. VII. Structure determination of the longer polypurine sequences present in the pancreatic ribonuclease digest of the viral RNA.


Effect of a DNA tumour virus on antibody forming cells in neonatally infected hamsters.


Transformation and virus growth by murine sarcoma viruses in human cells.


Prevalence, incidence and persistence of EB virus antibody in young adults.


Long-term follow-up of renal functions of 108 children who underwent nephrectomy for malignant disease.


The incidence of cytomegalovirus, herpes simplex, rubella, and toxoplasma antibodies in microcephalic, mentally retarded, and normocephalic children.


Telepathic perception in the dream state: confirmatory study using EEG-EOG monitoring techniques.


Carcinogenesis by RNA sarcoma viruses. XII. A quantitative study of infection of rat cells in vitro by avian sarcoma viruses.


The step in cellular DNA synthesis blocked by Newcastle disease or mengovirus infection.


Induction of virus synthesis in polyoma transformed cells by ultraviolet light and mitomycin C.


Ethylene production by detached leaves infected with tobacco mosaic virus.


A type of chick embryo cell that fails to support formation of infectious RSV.


Ampicillin sensitivity in infectious mononucleosis.


The effect of adrenergic drugs on the isolated tracheal tube in vitro and on the bronchial resistance to inflation in vivo.


Isolation and characterization of terminal polynucleotide fragments from bacteriophage ribonucleic acids.


Mechanistic studies on equine liver alcohol dehydrogenase. I. The stoichiometry relationship of the coenzyme binding sites to the catalytic sites active in the reduction of aromatic aldehydes in the transient state.


Phospholipid class and fatty acid composition of golgi apparatus isolated from rat liver and comparison with other cell fractions.


The composition and structure of carbohydrate moiety of stem bromelain.


Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. II. Conversion of geranylgeranyl pyrophosphate into diterpene hydrocarbons and partial purification of the cyclization enzymes.


Are beta-receptors involved in the uptake by cardiac sympathetic nerves of infused and released noradrenaline?


Nonspecific denervation supersensitivity in the rat vas deferens "in vitro".


Gram-negative bacilli in burns.

Gram-negative bacilli in burns. In a period of two years, 865 strains of Gram-negative bacilli other than Pseudomonas aeruginosa isolated from burns were identified by a range of tests. The commonest species were Proteus mirabilis, Escherichia coli, and Enterobacter cloacae. Many strains of Klebsiella aerogenes, Enterobacter aerogenes, and Bacterium anitratum were also found.A large proportion of the strains were tested for sensitivity to nalidixic acid, ampicillin, kanamycin, chloramphenicol, tetracycline, and carbenicillin, and smaller numbers of strains were tested for sensitivity to cephaloridine, polymyxin, streptomycin, sulphadiazine, sulfamylon, and trimethoprim. The proportion of strains sensitive and resistant to different antibacterial agents varied widely with species of bacteria. A large proportion of the strains of E. coli and P. mirabilis were resistant to ampicillin, which was much used in treatment; resistance appeared least often towards nalidixic acid, kanamycin, trimethoprim, and gentamicin. Multiple resistance occurred less often among strains of E. coli than among Klebsiella spp, Enterobacter spp, and P. mirabilis. Phage and serological typing of Ps. aeruginosa showed that most infections of burns with this organism were due to strains previously found in other patients in the same ward. Taken with other evidence, this supported the view that most infections with Ps. aeruginosa were not acquired from the patient's own flora but from sources in the hospital environment.


Relationship between nucleolus and nuclear bodies in human mixed salivary tumors.


Evolution of steroids and their value in the control of rheumatic disease.


Malignant hepatoma: evaluation of surgical (including needle biopsy) material from 69 cases.


Chemotherapeutic agents in childhood malignancies.


Chromosomes and abortions.

Chromosomes and abortions.


Neurologic surgery.

Neurologic surgery.


Amniocentesis: a new approach to some old problems in obstetrics.


Study on the action of olivine on macrophages "in vitro".


Effect of silica gel on stability and biological availability of ascorbic acid.


Effect of phenobarbital on rat liver acyl-phosphohydrolases.


Specificity of the renin-like enzyme of rabbit uterus.


A comparison of the effects of suxamethonium and tubocurarine in patients in London and New York.


Electroencephalographic study of diazepam on patients with diagnosis of episodic behavioral disorders.


The enzymic composition of the isolated cell wall and plasma membrane of baker's yeast. A study was made of the enzyme content of the isolated cell walls and of a plasma-membrane preparation obtained by centrifugation after enzymic digestion of the cell walls of baker's yeast. The isolated cell walls showed no hexokinase, alkaline phosphatase, esterase or NADH oxidase activity. It was concluded that these enzymes exist only in the interior of the cell. Further, only a negligible activity of deamidase was detectable in the cell walls. Noticeable amounts of saccharase, phosphatases hydrolysing p-nitrophenyl phosphate, ATP, ADP, thiamin pyrophosphate and PP(i), with optimum activity at pH3-4, and an activity of Mg(2+)-dependent adenosine triphosphatase at neutral pH, were found in the isolated cell walls. During enzymic digestion, the other activities appearing in the cell walls were mostly released into the medium, but the bulk of the Mg(2+)-dependent adenosine triphosphatase remained in the plasma-membrane preparation. Accordingly, it may be assumed that the enzymes released into the medium during digestion are located in the cell wall outside the plasma membrane, whereas the Mg(2+)-dependent adenosine triphosphatase is an enzyme of the plasma membrane. This enzyme differs from the phosphatases with pH optima in the range pH3-4 with regard to location, pH optimum, substrate specificity and different requirement of activators.


Trigeminal sensory neuropathy.

Trigeminal sensory neuropathy.


Virus in genital warts.

Virus in genital warts.


The influence of the pituitary gland on sodium conservation, and plasma renin and renin substrate concentrations in the rat.


Study of the reciprocal relationship of the exoantigens of Clostridium perfringens type A in the culture medium and the bacterial cells during cultivation.


Further purification of the glycoprotein that induces nephrotoxic antibody: isolation of the active polysaccharide fraction mainly composed of glucose.


Immune response of rabbits to purified papovavirus SV40.


Organization of flight motoneurons of diptera.


Intracellular recordings from cat cochlear nucleus during tone stimulation.


Excitability changes and inhibitory mechanisms in neocortical neurons during seizures.


Differential effects of septal and olfactory volleys on intracellular responses of hippocampal neurons in awake, sitting monkeys.


Pathogenesis of ulcers of the alkali-burned cornea.


An investigation of the products of an enzymic hydrolysis of collagens.


Human pituitary growth hormone. Studies of the tryptophan residue.


The glutamyl linkages in collagen.

The glutamyl linkages in collagen.


Free energy of subunit interactions. Hemerythrin.


Electron paramagnetic resonance of nitric oxide--protoheme complexes with some nitrogenous base. Model systems of nitric oxide hemoproteins.


Requirement of different sulfhydryl groups in the activation and transfer reactions of isoleucyl transfer ribonucleic acid synthetase.


Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.


Comparison of metal-binding properties of trans-1,2-cyclohexanediol diphosphate and deacylated phosphoinositides.


Use of venom exonuclease at low pH for preparation of mononucleoside diphosphates.


Chloroquine and synthesis of aminoacyl transfer ribonucleic acids. Tryptophanyl transfer ribonucleic acid synthetase of Escherichia coli and tryptophanyladenosine triphosphate formation.


Synthesis of some nucleotides derived from 3'-deoxythymidine.


Chloroquine and synthesis of aminoacyl transfer ribonucleic acids. Conformational changes in tryptophanyl and tryptophan transfer ribonucleic acids.


Effect of adenosine monophosphate on the reactivity of thiol groups of D-fructose 1,6-diphosphatase from rabbit liver.


Enzymatic synthesis of deoxyribonucleic acid. XXXIV. Termination of chain growth by a 2',3'-dideoxyribonucleotide.


A model for the role of metal ions in the enzyme-catalyzed hydrolysis of polyphosphates.


Glucokinase of Dictyostelium discoideum.


The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate.


The acid-soluble nucleotides of the copepod Euchaeta japonica Marukawa.


Intracellular pH of the peritoneal macrophage effects by silica and by drugs affecting cell metabolism.


Converting enzyme content of different tissues of the rat.


Glycogenosis type II: glycogen storage in cell cultures from muscle.


Enhanced synaptic effectiveness following prolonged changes in synaptic use.


Calcium dependent corticosteroid release from the perfused cat adrenal gland.


Anti angiotensin activity of plasma and R.B.C. in cirrhosis of liver and nutritional hypoproteinaemia.


Allosteric properties of glutaraldehyde-modified glycogen phosphorylase b. Selective desensitization of homotropic cooperativity.


Control of citric acid cycle activity in rat heart mitochondria.


Dual localization of beta-glucuronidase and acid phosphatase in lysosomes and in microsomes. II. Membrane-associated enzymes.


Phosphorylation sites, cytochrome complement, and alternate pathways of coupled electron transport in Euglena gracilis mitochondria.


An inducible alternate terminal oxidase in Euglena gracilis mitochondria.


Biological mechanisms involved in the formation of deoxysugars. VI. Role and function of enzyme-bound nicotinamide adenine dinucleotide in thymidine diphosphate D-glucose oxidoreductase.


Microbial culture preservation with silica gel.


Sensitivity of Pseudomonas aeruginosa to polymyxin B sulphate and EDTA: role of the divalent cation of the growth medium.


A liveborn infant with complete triploidy (69,XXX).


Simple comparison technique for measuring g-values in electron spin resonance spectroscopy.


Alteration of the RNA-DNA ratio of rat liver associated with the prevention of AZO dye carcinogenesis by dietary chloramphenicol.


Stein-Leventhal syndrome with masculinizing ovarian tumors. Report of 3 cases.


Industrial diseases of the central nervous system.


Preliminary evaluation of a decentralized community mental health clinic.


Antacids.

Antacids.


Facial pain.

Facial pain.


Comprehensive community mental health centers: a progress report 1969.


Neoplastic transformation of hamster astrocytes and choroid plexus cells in culture by polyoma virus.


Teaching through role-play.

Teaching through role-play.


Intervening in hostile behavior through dyadic and-or group intervention.


Electrophoretic patterns of ribosomal proteins from liver and hepatomas.


Psychosomatic illness and personality: a brief review of pertinent literature.


Utilization of body temperature indicator in psychiatric and geriatric setting.


Intensiveactivity program.

Intensiveactivity program.


Accidents--rarely accidental.

Accidents--rarely accidental.


Drug abuse--the 1969 social concern. 1.

Drug abuse--the 1969 social concern. 1.


Glycolipids from rabbit kidney.

Glycolipids from rabbit kidney.


Immunoelectrophoresis of rabbit antisera against phospholipid haptens.


A critical evaluation and review of ACTH (corticotrophin) in the treatment of acute exacerbations of multiple sclerosis.


Cell origin of collagenase in normal and wounded corneas.


Pneumonia with rapid widespread breakdown of lung tissue.


Progressive multifocal leukoencephalopathy. Identification of virions in paraffin-embedded tissues.


Open questions in the study of the "trophic" function of the nerve cell.


Corticosteroids9including ACTH) in Crohn's disease.


Carbohydrate metabolism in flight muscle of the tsetse fly (Glossina) and the blowfly (Sarcophaga).


Biosynthesis of amono acids by ruminal microorganisms.


Properties of a soluble nitrogenase in Azotobacter. A nitrogenase system that remains in the supernatant fluid after centrifuging for 3 hr at 180,000 x g can be extracted from Azotobacter vinelandii by osmotic lysis of the bacteria. This nitrogenase preparation is oxygen-labile and appears to be similar, though not identical, to that obtained from Clostridium pasteurianum. The particulate characteristic and oxygen stability of previously described preparations are likely due to the method of cell disruption, e.g., in the French pressure cell. The data support a nitrogenase model system in the intact cell in which oxygen-labile enzymes are protected from oxygen by the extensive internal membranous system which Azotobacter synthesize only when they fix nitrogen.


2,4-diaminovaleric acid: an intermediate in the anaerobic oxidation of ornithine by Clostridium sticklandii. The oxidation of ornithine in the presence of proline by crude extracts of Clostridium sticklandii cells was stimulated by nicotinamide adenine dinucleotide, coenzyme A, alpha-ketoglutarate, dimethylbenzimidazolyl cobamide (DBC) coenzyme, MgCl(2), and adenosine diphosphate. Deletion of various cofactors resulted in the accumulation of a new dibasic amino acid which was identified as 2,4-diaminovaleric acid. Both the oxidation of ornithine to alanine and acetate and the conversion of ornithine to 2,4-diaminovaleric acid were stimulated by addition of DBC coenzyme, and both were inhibited by intrinsic factor, an inhibitor of cobamide coenzyme-dependent reactions. This inhibition was reversed by addition of DBC coenzyme. However, the oxidation of 2,4-diaminovaleric acid was insensitive to added intrinsic factor. The data indicate that 2,4-diaminovaleric acid represents the first intermediate in the oxidation of ornithine by C. sticklandii.


A new method for the measurement of acute alterations in thyroxine deiodination rate in man. A newly devised dual labeled iodine isotopic method is described for the detection and quantitation of alterations in thyroxine (T(4)) deiodination rate in man. This method employs the principle of a constant (125)I infusion to serve as a reference source for the generation of (131)I derived from the deiodination of T(4)-(131)I. Measurement of these two iodide isotopes are made in serially timed urine collections and are expressed in terms of a ratio value. Using this technique, it was possible to measure accurately the effects of a single dose of 6-propylthiouracil (6-PTU) in producing inhibition of T(4) deiodination in euthyroid subjects. It was also possible to assess the time of onset, duration of action, and degree of inhibition produced by 6-PTU. Employing single doses of 6-PTU, ranging from 100 to 1000 mg, there was found to be a log dose relationship with a degree of inhibition observed in T(4) deiodination. In control studies T(4) deiodination rate was found to be constant for periods ranging up to 72 hr in normal ambulating subjects. The acute administration of many other agents was employed in an attempt to alter the T(4) deiodination rate. These included diphenylhydantoin, methimazole, triiodothyronine, thyroxine, thyroid stimulating hormone (TSH), adrenocorticotropin (ACTH), hydrocortisone, predinsolone, potassium iodide, epinephrine, and oxytocin. No detectable change in T(4) deiodination rate was observed with these agents in the dosage ranges employed in this study. The lack of any observable alteration in the T(4) deiodination rate in response to this array of drugs and hormones appears to indicate that the availability of T(4) to intracellular sites of deiodination and possibly action is well modulated to resist abrupt changes.


Biosynthesis of cytidine diphosphate diglyceride by human platelets. Homogenates of human platelets contain an enzyme which catalyzes the formation of cytidine diphosphate diglyceride from cytidine triphosphate and phosphatidic acid. The enzymatic activity could not be dissociated from platelet particles and the greatest specific activity was found in the membrane fraction. The K(m) for cytidine triphosphate was 0.16 mmole/liter and the apparent K(m) for phosphatidic acid was 6.2 mmoles/liter. The pH optimum was 7.0 and the most effective buffers were triethanolamine-HCl and Tris-HCl. The reaction was dependent on the presence of divalent cations, magnesium being the most effective of those investigated. Monovalent cations did not alter the reaction rate. Evidence is presented that the cytidine diphosphate diglyceride produced can serve as a precursor for the synthesis of phosphatidylinositol. No difference was found in the enzymatic activity in platelets from normal subjects and from patients with diseases known to interfere with platelet thromboplastic function.


Course of air-borne infection caused by B virus (Herpesvirus simiae). 4. Role of alveolar macrophages of the lungs in inhalation B-virus infection of rabbits.


Lymphomatous lesions induced in chickens by cellular inoculum.


Electron reactions in gamma-irradiated thymidine and cystamine.


Trigeminal sensory neuropathy in connective-tissue disease.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 9-1970.


Acetylcholine sensitivity and distribution on mouse neuroblastoma cells. Action potentials resulted from iontophoretic application of acetylcholine to cloned mouse neuroblastoma cells maintained in culture. Cell bodies were sensitive to acetylcholine, but half the cells were insensitive along one of their processes, suggesting an analogy with normal axons and dendrites. Some cells were electrically coupled via their processes, but no chemically mediated synaptic transmission was seen.


Overgrowth stimulating factor released from Rous sarcoma cells. An assay is described for a nonzviral factor from the medium of Rous sarcoma cells which stimulates rapid and sustained cellular overgrawth in crowded chick embryo cultures. The factor is nondialyzable and thermnolabile and is released in large amounts several days after the first visible transformation of newly infected chick embryo cells.


Primary adenoid cystic carcinoma of the breast.


Ultrastructural features of extramammary Paget's disease.


A new approach to active immunization of sheep by a combined sheep pox and anthrax vaccine.


Electron microscopic demonstration of the causative agent of inclusion body rhinitis in pigs.


Activity of the phenylalanine hydroxylating system in liver of newborn, suckling and adult rats.


On the release of enzymes upon lysozyme treatment of Streptomyces.


Biologic and morphologic analysis of growth and cellular pattern of tissues from mice with viral leukemia cultured in vitro.


Cytochemistry of chronic Nissl disease.

Cytochemistry of chronic Nissl disease.


A spin label for tyrosine residues.

A spin label for tyrosine residues.


Purification and properties of two iron-sulfur proteins from Azotobacter vinelandii.


Methylation of transfer RNA and of ribosomal RNA in rat liver in the intact animal and the effect of carcinogens.


Collagenase activity in a particulate fraction from Bacteroides melaninogenicus.


Studies on the nucleotide arrangement in deoxyribonucleic acids. 13. Frequency and composition of purine isostichs in calf-thymus deoxyribonucleic acid.


Rous sarcomas in mice: the chromosomal progression in primary tumours.


Rat hepatoma cell surface antigens: demonstration and isolation of membrane-associated isoantigens.


A shift of liver aldolase towards the muscle type in hepatoma: immunological study.


Solubilization and partial fractionation of the sulphur-containing nuclear proteins of hepatoma 223 ascites cells.


Magnetic susceptibilities of horse erythrocyte catalase and its derivatives in the range from room temperature to 4.2 degrees K.


Cytochromes of Bacillus subtilis. 3. Physicochemical and enzymatic properties of cytochromes c-550 and c-554.


Effect of parathyroid hormone on rat kidney microsomes in vivo.


Stimulation of 14C-leucine incorporation into protein in vitro by rapidly sedimenting nucleolar RNA from AH-130 hepatoma cells.


Collagenase in bone of man.

Collagenase in bone of man.


The intermediate muscle fiber of rats and guinea pigs.


Gradient-thickness thin-layer chromatography for the isolation and analysis of trace amounts of free fatty acids in large lipid samples. A thin-layer chromatographic method for quantitative isolation of free fatty acids is described. This method appears to be more satisfactory than existing methods in offering the combination of advantages of specificity, simplicity, rapidity, reproducibility, accuracy, high sensitivity, and applicability as a preparative technique. The method involves chromatography on a thin-layer plate on which the layer of Silica Gel G decreases linearly in thickness from 1000 micro at the base to 125 micro at the upper end. This gradient-thickness design allows the separation and densitometric quantitation of very small traces of free fatty acids from relatively large and complex lipid samples in a single chromatographic step. The method has been shown to be applicable directly to the crude total lipid extracts of several mammalian tissues. It appears to generate little if any artifactual free fatty acids from the breakdown of complex lipids, in contrast to the undesirable behavior of silicic acid columns in this respect. Gradient-thickness thin-layer chromatography promises to be useful for the quantitative isolation of trace amounts not only of other types of lipids but also of classes of compounds other than lipids.


Augmentation of pressor response to renin and increased renin release in rats with mercuric chloride intoxication and with bilateral ureteral ligation.


Composition of human serum sphingomyelins. Serum sphingomyelins were analyzed by argentation chromatography of the corresponding ceramide diacetates. Six subfractions were obtained. Three of them contained 4-sphingenines in combination with saturated, trans-, or cis-monoenoic fatty acids; the remaining three contained sphingadienine, also in combination with saturated, trans-, or cis-monoenoic fatty acids. Palmitic acid was the principal fatty acid combined with 4-sphingenines, while nervonic acid was the principal fatty acid combined with sphingadienine. About 4% of the total fatty acids of sphingomyelin were trans-monoenoic. They were comprised of many positional isomers of straight-chain C(22-24) compounds. The cis-monoenoic acids made up 33% of the total acids and consisted of almost pure nervonic acid. The rest of the acids were saturated. The 4-sphingenines contained small amounts of iso-C(18) and anteiso-C(19) compounds in addition to the straight-chain C(16-18) bases.


A particular pharmacological effect on the propagation of experimental strychnine and penicillin epilepsy.


Potentiation by angiotensin of responses to endogenously released noradrenaline in the pithed rat.


Subcellular fractionation of bovine splenic nerves.


Angiotensin and aldosterone in renovascular hypertension.


The anaerobic interaction of ferrocytochrome c with the "ferric" and "oxygenated" forms of purified cytochrome c oxidase. XVI. Cytochrome oxidase and its derivatives.


Electron spin resonance measurement on ubiquinone-depleted and ubiquinone-replenished submitochondrial particles.


Oxidative phosphorylation in Azotobacter vinelandii particles. Phosphorylation sites and respiratory control.


Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells.


Photoreactions of flavin mononucleotide and a flavoprotein with zwitterionic buffers.


Extraction, separation and labeling with 14C-glucose of HeLa cell polyglucose, RNA and DNA and comparison of the molecular weights and buoyant densities of polyglucose from poliovirus-infected and noninfected cultures.


Demonstration in vitro of competition between added NADH and glutamate for oxidation by liver mitochondria.


Induction of kidney tumours in the rats by feeding Encephalartos hildebrandtii for short periods.


Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells.


The modification of labeled cytidine and thymidine incorporation into mitochondrial and nuclear DNA in normal liver, hepatoma 3924A and its host liver by isoproterenol.


The antigen involved in immune adherence with stratum corneum and human serum.


Parainfluenza-3 vaccine in cattle: comparative efficacy of intranasal and intramuscular routes.


Epidemiology of vesicular stomatitis virus: some new data and a hypothesis for transmission of the Indian serotype.


Moenomycin. VII. Isolation and properties of further components of the antibiotic moenomycin.


Cytochrome c oxidase. The bathocuproine effect.


A reappraisal of copper depletion from cytochrome c oxidase.


Reversible dissociation of tetrameric 7.4 S rabbit muscle glyceraldehyde 3-phosphate dehydrogenase into 4.4 S dimers by' ammonium sulfate and into 3.2 S monomers by KC1.


Partial purification and characterization of deoxyribonucleic acid polymerase from KB cells.


The isozymes of glutamate-aspartate transaminase. Mechanism of inhibition of dicarboxylic acids.


Role of cyclic adenosine 3',5'-monophosphate in the induction of hepatic enzymes. I. Kinetics of the induction of rat liver serine dehydratase by cyclic adenosine 3',5'-monophosphate.


The properties of rabbit muscle glyceraldehyde 3-phosphate dehydrogenase labeled with a "reporter group".


Protamine kinase from rainbow trout testis. Partial purification and characterization.


Structure and function of transfer ribonucleic acid. IV. Complexes between valyl transfer ribonucleic acid synthetase and structurally modified transfer ribonucleic acid specific for valine.


Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa.


Pyrimidine biosynthesis de novo in skin.


Synthesis and activity of a new class of heterocyclic compounds against Entamoeba histolytica. 1,2,3,3a-tetrahydro-1-alkylcyclopenta[de]quinolines.


Tryptophan and nitrogen metabolism and pregnancy of the rat as affected by dietary supplementations with leucine and with amino acid mixtures.


Experimental studies on dynamic behavior of cells in subcutaneous solid tumor (MH 134-C3H-He).


Isolation of a clone of herpes simplex virus highly attenuated for newborn mice and hamsters.


Tumor induction in adult mice by SR-RSV material with syngeneic embryo cells.


Studies on rous sarcoma virus in mice. 3. Three lines of SR-RSV-induced mouse ascites sarcoma.


Two cell strains of tissue culture, JTC-15 and -16, from rat ascites hepatomas, AH-66 and -7974.


Intradural granulomatous neuritis. Report of cases of granulomatous neuropathy of v, xii and ix cranial nerves and of cauda equina.


Successful pregnancy in a patient with Sheehan's syndrome.


Interstitial nephritis in a dog associated with infectious canine hepatitis virus.


A modified method for the isolation of the plasma membrane from rat liver.


The solubilization and gel electrophoresis of membrane enzymes by use of detergents.


Inhibition of rat liver adenyl cyclase by adenosine and adenine nucleotides.


Collagenolytic enzymes in human serum.

Collagenolytic enzymes in human serum.


The effect o angiotensin II on the platelet aggregation induced by adenosine diphosphate, epinephrine and thrombin.


The effect of abdominal wounding on the rate of tissue regeneration.


Effects of hyperbaric oxygenation on metabolism. VI. Efficacy of protective agents at 5,7,9, and 11 atmospheres of 100 percent oxygen.


Influence of synthetic double-stranded ribonucleic acid (poly I:C) on SV40 viral oncogenesis and transplant tumor in hamsters.


Occurrence of phentypically mixed viruses in the Bryan high-titer strain of Rous sarcoma virus and RSV (RAV-1) stocks.


Effect of hyperphysiological levels of hexestrol on the hepatic metabolism of nicotinate in the mouse.


Studies on interferon induction by the mouse mammary tumor virus.


Rhinovirus replication in suspension cultures of HeLa cells.


Antigenic variation of rhinovirus type 22.


Histochemical studies on the effect of imuran on the muscular phase of trichinellosis in mice.


Pathomorphology of muscular trichinellosis in comparative histological, histochemical, ultrastructural, autoradiographic and immunofluorescent investigations.


Decreased aldosterone production by rat adrenal tissue in vitro due to treatment with 9-alpha-fluorocortisol, dexamethasone and adrenocorticotrophin in vivo.


Biosynthesis of adrenal corticosteroids: energy metabolism and the hydroxylases.


Deoxycytidylate deaminase and related enzymes of thymidine triphosphate metabolism in hepatomas and precancerous rat liver.


Ultrastructure of the glomus jugulare tumor.


Oestrogen metabolism in liver disease.

Oestrogen metabolism in liver disease.


Acute tapioca poisoning in a child.

Acute tapioca poisoning in a child.


Pharmacological redundancy as an adaptive mechanism in the central nervous system.


Effects of antilymphocytic serum on bacterial and viral infections and virus oncogenesis.


The lipids of mitochondria of human gray and white matter.


Gas liquid chromatographic analysis of sphingosine bases in sphingolipids of human normal and multiple sclerosis cerebral white matter.


Phospholipid class and fatty acid composition of developing spinal cord in normal pigs and in congenital tremor (Myoclonia congenita).


Molecular species of phosphatidyl ethanolamine from egg yolk.


Electron spin resonance of irradiated single crystals of L-phenylalanine-HCl. Single crystals of L-phenylalanine-HCl have been observed with electron spin resonance after irradiation with a cobalt 60 gamma-ray source. The predominant signals observed are from long-lived benzyl radicals. The results indicate that one form of radiation damage to proteins containing this amino acid is breakage of the carbon-carbon bond to release the benzyl radical from the polypeptide chain. Hyperfine structure due to proton couplings of the two methylene hydrogens and of the hydrogens on the ring of the benzyl radical is observed and analyzed to give the electron spin density on the various carbons. The spin density on the methylene carbon is found to be 0.71; that on carbon C((2)), C((4)), or C((6)) is 0.17. The sum of the spin densities on C((1)), C((3)), and C((5)) is -0.22.


Evidence for a role of cyclic AMP in neuromuscular transmission. Experiments were undertaken to determine if the effects of epinephrine in promoting neuromuscular transmission were mediated by adenosine 3':5'-cyclic phosphate (cyclic AMP). Dibutyryl cyclic AMP and the methyl xanthines, theophylline and caffeine (which inhibit cyclic AMP hydrolysis), were found to increase the amplitude of the end plate potential in the isolated rat diaphragm. Like epinephrine (which is known to promote cyclic AMP synthesis), these agents appear to facilitate the release of acetylcholine from the motor neuron. This interpretation is supported by the observation that theophylline and dibutyryl cyclic AMP markedly increased the frequency but not the amplitude of the spontaneous miniature end plate potentials. In addition, these drugs increased the number of transmitter packets released in response to nerve stimulation. These results are consistent with the view that cyclic AMP plays a role in the release of acetylcholine and in the "defatiguing effect" of epinephrine.


Orientation of lipid spin labels in lecithin multilayers. Nitroxide-labeled stearic acid and cholestane have been incorporated into lecithin multilayers. The pronounced anisotropy of the preparations reflects a nonrandom structure of the lecithin film and demonstrates that these lipid probes can report structural information from lipid regions resembling those thought to occur in membranes. These two probes differ with respect to the orientation of the NO bond to the long axis, but both orient with their long axes perpendicular to the phospholipid film. Simulated spectra, calculated on the basis of a Gaussian distribution of orientations, are in agreement with the experimental results.


Effects of antilymphocytic serum on host responses to infectious agents.


Orientation and motion of amphiphilic spin labels in membranes. The paramagnetic resonance spectra of N-oxyl-4','-dimethyloxazolidine derivatives of 12-ketostearic acid, 5-ketostearic acid, 5-ketotricosanoic acid, and 5alpha-androstan-3-one-17beta-ol have been observed in sonicated phospholipid dispersions, the walking-leg nerve fibers of Homarus americanus, and in erythrocytes oriented by hydrodynamic shear. The preferred orientation of these spin labels in the nerve and erythrocyte membranes is one in which the long amphiphilic axis is perpendicular to the membrane surface. The resonance spectra indicate that these labels in the nerve fiber are bound to a lipid bilayer very similar to that found in the sonicated phospholipid dispersion, whereas any lipid bilayer in the erythrocyte must be much more rigid.


Effects of antilymphocyte serum on the induction of neoplasms of lymphoreticular tissues.


Magnetic resonance studies of spin-labeled creatine kinase system and interaction of two paramagnetic probes. Creatine kinase from rabbit muscle has been specifically labeled with a derivative of a nitroxide free radical on the two essential sulfhydryl groups, one per active site. The conformation in the environment of the enzyme-bound free radical and the change in conformation induced upon binding of the substrate, metal adenosine diphosphate, has been monitored by two parameters of the bound spin label, its electron paramagnetic resonance spectrum and its contribution to the proton relaxation rate of water. The specificity in activation of the enzymic reaction of the series of alkaline earth ions, Mg, Ca, Sr, Ba, was not reflected by differences in conformation of the ternary enzyme metal substrate complexes observable with the spin probe. However, with the inhibitory zinc ion, the conformation of ternary complex was distinctly different. The electron paramagnetic resonance spectra of complexes with two paramagnetic probes, namely, spin-labeled enzyme with paramagnetic metal adenosine diphosphate complexes (Mn(II), Ni(II), and Co(II)) revealed a spin-spin interaction between the protein-bound free radical and the paramagnetic metal ions. From the magnitude of the interaction, the distance between the manganous ion and the electron spin of the nitroxide moiety in the MnADP-spin-labeled creatine kinase was estimated to be in the range of 7-10 A.


Alpha-keto acid dehydrogenase complexes. XI. Comparative studies of regulatory properties of the pyruvate dehydrogenase complexes from kidney, heart, and liver mitochondria. The activity of the multienzyme pyruvate dehydrogenase complexes, isolated from mitochondria of beef kidney, beef heart, and pork liver, is regulated by phosphorylation and dephosphorylation. Phosphorylation and concomitant inactivation of each of the three complexes are catalyzed by an ATP-specific kinase, and dephosphorylation and concomitant reactivation are catalyzed by a phosphatase. The phosphatase has been separated from the other component enzymes of each pyruvate dehydrogenase complex, and the three phosphatases are functionally interchangeable. The kinase has been isolated from the beef kidney complex, and it is functional with the beef heart and pork liver complexes. ADP is competitive with ATP, and the ADP effect is more pronounced with the kidney kinase than with the liver and heart kinases. Pyruvate protects strongly the heart and liver pruvate dehydrogenase complexes and, to a lesser extent, the kidney complex against inactivation by ATP. Pyruvate apparently exerts its effect on the pyruvate dehydrogenase component of the complex, rather than on the kinase.


The acrasin activity of 3',5'-cyclic nucleotides. 3',5'-Cyclic nucleotides are acrasins for the cellular slime mold, Dictyostelium discoideum; they have chemotactic activity on the myxamoebae at very low concentrations. However, not all cyclic nucleotides can evoke the adhesiveness necessary for aggregate formation. 2',3'-Cyclic nucleotides and dibutyrylcyclic adenosine monophosphate are not acrasins, though they enhance the rate of differentiation and morphogenesis. The addition of 3',5'-cyclic nucleotides to agar test plates stimulates the rate of morphogenesis. While the stimulatory effect of cyclic nucleotides is concentration-dependent, it is fairly uniform between pH 5 and 7, with an optimum at pH 6. The acrasins may be metabolized by extracellular phosphodiesterase to 5'-nucelotides which may then stimulate differentiation and morphogenesis.


Rates of GDP-induced and GTP-induced depolymerization of glutamate dehydrogenase: a possible factor in metabolic regulation. The rate of the depolymerization of beef liver glutamate dehydrogenase induced by coenzyme and the purine nucleotides guanosine 5'-diphosphate and guanosine 5'-triphosphate, which are potent inhibitors of enzymatic activity, has been measured by rapid light scattering techniques and by absorbancy changes with stop flow. It is shown that the rate constant for this process may vary from several milliseconds to several seconds depending upon the nucleotides used. The widely varying rate constants for the nucleotide-induced depolymerization may serve a role in determining the nature of the regulation of enzyme activity by nucleotides. Depolymerization induced by guanosine 5'-diphosphate in the presence of diphosphopyridine nucleotide is slower than in the presence of triphosphopyridine nucleotide as coenzyme, and this difference is apparently due to the isomerization of the enzyme as a result of diphosphopyridine nucleotide binding to a second, nonactive site. This binding, as well as binding of the coenzyme to the active site, may be conveniently measured by a purine nucleotide-induced spectral shift in the coenzyme absorption spectrum. It is also shown that complete depolymerization of the enzyme in the presence of guanosine 5'-triphosphate is accomplished by about half saturation of the coenzyme active sites (6-8 active "monomer").


Mouse leukemia virus: "spontaneous" release by mouse embryo cells after long-term in vitro cultivation. BALB/c mouse embryo cells maintained in tissue culture on a schedule of rapid transfer at high cell density develop into tumorigenic lines that have lost contact inhibition of cell division. After several months in culture, certain of these lines begin to release mouse leukemia virus. This virus has properties indistinguishable from those of virus found in adult BALB/c mice. The evidence presented here demonstrates that the murine leukemia virus genome must be present in the original embryo cultures. The possibility that the genetic information for making murine leukemia virus is present in a repressed form in every mouse embryo cell is discussed.


Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids). Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.


Radical transformation in irradiated DNA and its constituents. Electron spin resonance spectroscopy has been used to study transformation of radicals in DNA and a number of its constituents. It was found that in all the bases irradiated at 77 degrees K, hydrogen-addition radicals were formed on warming. The following mechanism of radical transformation has been proposed: damaged species, probably ion-radicals, release hydrogen atoms on warming, which then add to the undamaged bases, preferentially thymine. Thymine need not be the place of the primary damage.


Lipid composition of adenovirus-induced tumor.


Enzyme changes in the hereditary ataxic rabbit.


Rate and ways of resolution of hypertensive vascular disease.


Infectious mononucleosis in acute leukemia with rising Epstein-Barr virus antibody titers.


Enzymatic control of the metabolic activity of Pseudomonas aeruginosa grown in glucose or succinate media.


The effect of ethionine on hepatic gluconeogenesis in the rat.


The influence of polyenes on cyclic 3',5'-AMP formation and glucose utilization in thyroid.


Evidence for a functional pyridine nucleotide cycle in Escherichia coli.


Isolation and identification of a paramagnetic complex from the livers of carcinogen-treated rats.


Developments in steroidal hormonal contraception.


The redox state of the mitochondrial NAD system in cirrhosis of the liver and in chronic quantitative undernutrition in the rat.


A method for the large scale preparation of the avian erythrocyte specific histone F2C.


Intracellular localization of phosphodiesterases I and II in rat liver.


Interconversion in vitro of two forms of liver phosphorylase phosphatase.


The immunochemistry of Shigella flexneri O-antigens. The structure and biosynthesis of the O-specific side chains of some representative serotypes.


The activation of phosphorylase in neonatal rat liver.


Carcinomas of the glandular stomach and other organs of rats induced by 4-hydroxyaminoquinoline 1-oxide hydrochloride.


NAD biosynthesis in rabbit erythrocytes and reticulocytes after whole-body x-irradiation.


Synthesis and release of proinsulin and insulin by human insulinoma tissue.


A case of a partial defect of the iodide trapping mechanism.


Factors influencing the urinary excretion of 3',5'-adenosine monophosphate in humans.


Malignant lipid cell tumor of the ovary: clinical, biochemical and etiologic considerations.


Secretion rates of cortisol and aldosterone precursors in various forms of congenital adrenal hyperplasia.


Asymptomatic cytomegalovirus infection following blood transfusion in tumor surgery.


Virologic study on an outbreak of infantile diarrhea.


Effect of hormones on the biosynthesis of nicotinic acid from tryptophan in man.


Attempts at analysis of toxicity of pertussis vaccine. II. Quantitative determination of the heat-labile toxin by skin reaction.


Myelography. Past and present (1935-1968).


Is it bad to be blue?

Is it bad to be blue?


Mucoid bone marrow without carcinoma deposits.


Planning the appropriate operations for islet cell tumors of the pancreas.


Intradiscal measurements of pH in patients with lumbar rhizopathies.


A direct thiobarbituric acid-reacting chromogen in human red blood cells.


Serum hyaluronidase activity in chronic liver damage.


Proposition for an international angiotensin standard for renin measurement in human plasma.


Plasma phospholipids in cirrhosis of liver and fatty liver.


Neuropathology.

Neuropathology.


General neurophysiology (biochemical aspects).


Psychoanalysis.

Psychoanalysis.


Peripheral nerve surgery.

Peripheral nerve surgery.


Regional physiology of the nervous system.


Arginine in viomycin biosynthesis.

Arginine in viomycin biosynthesis.


Myelin constituents of human central nervous system.


Collagenase from rat uterus. Isolation and partial characterization.


Modulation of heart muscle mitochondrial malate dehydrogenase activity. I. Activation and inhibition by p-mercuribenzoate.


Modulation of heart muscle mitochondrial malate dehydrogenase activity. II. p-Mercuribenzoate activation, model of a possible allosteric control mechanism for substrate homeostasis.


The degradation of trans-ferulic acid by Pseudomonas acidovorans.


Amino acid transfer factors from yeast. 3. Relationships between transfer factors and functionally similar protein fractions.


Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin.


Differential levels of stage IV sleep in a group of clinically similar chronic schizophrenic patients.


Neuronal activity during wakefulness and sleep: some comments.


The maximal capacity for sleep: rapid eye movement density as an index of sleep satiety.


Neurohumoral aspects of sleep control.

Neurohumoral aspects of sleep control.


REM deprivation and schizophrenia.

REM deprivation and schizophrenia.


Cerebral amino acids during deprivation of paradoxical sleep.


Efficiency of verbal learning during sleep as related to the EEG pattern.


The sensitivity of cortical neurones to acidic amino acids and acetylcholine.


Effect of angiotensin and atropine on the spontaneous release of acetylcholine from cat cerebral cortex.


The effect of moderate hypoxia and ischemia on cytochrome oxidase activity and protein synthesis in brain mitochondria.


The postsynaptic inhibition of rabbit oculomotor neurones by secondary vestibular impulses and its blockage by picrotoxin.


Post-tetanic potentiation at the neuromuscular junction of the frog in the presence of tetrodotoxin.


Influence of age on experimental cutaneous calcification.


Regulation and mechanism of phosphoribosylpyrophosphate synthetase. II. Excchange reactions catalyzed by the enzyme.


Adrenocorticotropin stimulation of 2-ketoglutarate oxidation by isolated rat epididymal adipose tissue. Mediation by cyclic adenosine 3',5'-monophosphate and relationship to lipid metabolism.


Catalytic facilitation in vitro by two multienyzme complexes from Neurospora crassa.


Electron paramagnetic resonance spectra of manganese (II)-protein complexes. Manganese (II)-concanavalin A.


The diphtheria toxin-dependent adenosine diphosphate ribosylation of rat liver aminoacyl transferase. II. General characteristics and mechanism of the reaction.


A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans.


Evidence for tolerance to SV40 tumor antigen in hamsters bearing para-adenovirus 12 tumor transplants.


Immunochemical studies of foot-and-mouth disease. VI. Differences in antigenic determinant site recognition by guinea pig 19S and 7S antibodies.


A reaginic type of antibody stimulated by extracts of Bordetella pertussis in inbred strains of mice.


Measurement of antibody against human IgG by the neutralization of IgG-sensitized herpes simplex virus.


Phospholipids in cultured guinea pig skin.


Effects of black widow spider venom on the frog neuromuscular junction. Effects on end-plate potential, miniature end-plate potential and nerve terminal spike.


Effects of black widow spider venom on the frog neuromuscular junction. Effects on the fine structure of the frog neuromuscular junction.


Comparative studies of gliomas in vitro and in vivo.


Probable occurrence of infectious bovine rhinotracheitis virus in Tanzania in wildlife and cattle.


Grades of malignancy of tumours of neuroectodermal origin.


Lung cancer in the Hungarian plain.

Lung cancer in the Hungarian plain.


Outbreak of Hong Kong influenza in Milwaukee, winter of 1968-69.


Moving strip irradiation in the treatment of extensive neoplastic disease in the chest.


Lung cancer among the Jews.

Lung cancer among the Jews.


Irradiation of the liver in children: review of experience in the acute and chronic phases, and in the intact normal and partially resected.


Babesia rodhaini: carbohydrate metabolism and infectivity for rats of cells freed from host erythrocytes.


Calcification of the basal ganglia following radiation therapy.


The use of sulphite-containing media in the isolation of Clostridium welchii.


Separation of conjugated urinary estrogens on columns of sephadex. I. Optimization of conditions.


To sleep: to die.

To sleep: to die.


The pharmacology of disordered sleep. A laboratory approach.


Pharmacologic and physiologic aspects of anesthesiology. II.


Labelling of antigens by various isotopes.


Studies on mycobacterial sensitizing fractions. IV. Fractionation of components of unheated M. tuberculosis and BCG culture filtrates by successive precipitation with CH3COOH, HClO4 and CCl3COOH.


Elucidation of factor(s) responsible for growth stimulation in Entamoeba histolytica.


The transfer function of frog myoneural junctions. II. The influence of previous conditions in situ upon the invitro responses to pulse trains.


Left ventricular function during the early and late stages of scar formation following experimental myocardial infarction.


Selective inhibition by chloramphenicol of ACTH-induced reorganization of inner mitochondrial membranes in fetal adrenal cortical cells in tissue cultures.


Sleep disturbance in acute schizophrenic patients.


An experimental approach to dreams and telepathy. II. Report of three studies.


Angiotensin converting enzyme: method of assay and partial purification.


Micro procedure for determination of pyrophosphate and orthophosphate.


A new spectrophotometric micro determination of vicinal diols.


Microdetermination of guanine ribonucleotides by an enzymic amplification technique.


Cytomegalovirus in the inner ear. Case report and electron microscopic study.


Role of interferon in the propagation of MM virus in L cells. MM virus propagated in mouse brain replicates to low titers in L cells without production of cytopathic effect (CPE). After growing the virus in BHK-21 cells, however, the virus replicates to high titers in L cells with complete CPE. It was found that suspensions of MM virus propagated in L cells directly from the mouse brain contained much more interferon than did suspensions of virus which had first been grown in BHK-21 cells. Mouse brain suspensions of the virus were also found to contain high interferon titers. Treatment of L cells with actinomycin D before infection with mouse brain-grown virus resulted in full virus replication with CPE. BHK-21 cell-grown virus diluted in L cell interferon behaved like mouse brain-grown virus in L cells. It is concluded that the presence of interferon in the inoculum is largely responsible for the suppression of MM virus replication in L cells.


Combined screw-cap and rubber-stopper closure for Hungate tubes (pre-reduced anaerobically sterilized roll tubes and liquid media). A double-closured method introduced for Hungate tubes eliminates clamps or special racks to hold the rubber stoppers in place while the tubes are being processed. The system prevents stoppers from being dislodged by gas-producing anaerobes and keeps the stoppers sterile so that the closed system of transfer can be conveniently utilized. Open and closed systems for handling a gas-producing anaerobe were compared. Ten tubes containing Clostridium perfringens were opened; the organism was detected in the air by use of an impingement collector. The gloved hand of the operator also revealed the test organism. A similar trial with culture material removed by the closed system (syringe transfer) resulted in no detectable contamination of the environment.


Utilization of electron spin resonance spectroscopy for observation of in vivo response to fungicides. Electron spin resonance studies of the in vivo response to fungicides (chloranil and thiram) by Aspergillus niger of different ages are described. The spores possessed a natural free radical signal which grew rapidly upon application of chloranil. Thiram, on the other hand, produced weak changes in the free radical region but easily detectable changes at lower fields, indicating involvement of copper and iron. In addition, flow experiments are described in which the production and decay of the chloranil semiquinone radical produced in the reaction of solutions of chloranil with extracts of bakers' yeast were monitored, both in the absence and in the presence of several buffers and respiratory chain inhibitors.


Bordetella pertussis serotypes in the United States. To determine the Bordetella pertussis serotypes currently causing whooping cough in the United States, recently isolated cultures from different geographic areas were studied. Specific adsorbed antisera were prepared in our laboratory and used in both tube and slide agglutination tests. Among the 177 cultures isolated during 1966 and 1967 in seven states and one Canadian province, the predominant serotype was 1.3 (or 1.3.6), represented by 85% of the cultures. Fifteen cultures were serotype 1.2.3.4.6. The 376 cultures isolated in the Grand Rapids area during the last 30 years showed a changing pattern from serotype 1.2.3 during the early years to the currently prevailing 1.3 (or 1.3.6). During the 2-year study period, seven cultures of B. parapertussis were isolated in Michigan, and seven were received from other states. One culture of B. bronchiseptica, recovered from a child in Boston, was sent to us.


Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Rotenoids and related compounds were investigated for their effects on animal and plant viruses. Of 35 compounds examined, rotenone, rotenone norketone, acetylrotenone, acetylrotenone norketone, deguelin, deguelic acid, dehydrodeguelin, and isotubanol norketone, all used at low concentrations, suppressed the growth of Newcastle disease and herpes simplex viruses as determined by the agar diffusion, plaque inhibition method. Most of the compounds likewise decreased the number of necrotic spots on tobacco mosaic virus-infected leaf discs. Only derrisic acid completely inhibited the local lesion formation at subphytotoxic concentrations. Correlation of antiviral activity with respiratory inhibition of these compounds is discussed.


An amyloid forming nodular syringocystadenoma.


Correlations between virulence and other characters of Clostridium perfringens type A. The correlation analysis which has already proved its value in ecology has not yet been applied to the determination of virulence indicators. Its application to a group of Clostridium perfringens type A strains has brought out some characters that may be considered as virulence indicators. This study suggests that the toxicity of the culture supernatant fluids for mice is significantly correlated with the virulence for mice and guinea pigs. A significant correlation was found between the virulence of the fluid cultures for mice or guinea pigs and the coagulation of milk, production of gas (in deep agar), hydrogen sulfide production, and fermentation of glucose, sucrose, maltose, and levulose.


Studies on cholinergic transmission in the medial geniculate nucleus. 1. Studies were made on the effects of iontophoretically and intravenously administered cholinergic antagonists on the synaptic responses of medial geniculate (MG) neurones evoked by stimulation of the auditory cortex, inferior colliculus and mesencephalic reticular formation.2. Atropine specifically blocked a proportion of the excitatory responses evoked by stimulating the auditory cortex, inferior colliculus and reticular formation, although it was without effect on some of them.3. Neostigmine and eserine facilitated some excitatory synaptic responses evoked by inferior collicular stimulation.4. It is suggested that the feline MG nucleus receives excitatory cholinergic, as well as non-cholinergic, pathways from the auditory cortex, inferior colliculus and lower brain stem. The cholinergic pathways from the auditory cortex may be either corticofugal fibres or recurrent axon collaterals of afferent projections from the MG nucleus to the cortex. Those from the lower brain stem are possibly the cholinesterase-containing fibres described by Shute & Lewis (1967).


Germination of Macrophomina phaseoli sclerotia as effected by Pinus lambertiana root exudate.


Vascular resistance in the perfused isolated rat tail. 1. A constant flow perfusion system using the isolated rat tail has been developed to facilitate the study of resistance vessel behaviour and the action of vasoactive drugs.2. Baseline resistance remains stable for several hours and dose response curves to bolus injections of pressor agents are reproducible when dialysed bovine serum albumen is used in the perfusion medium to maintain osmotic pressure.3. Noradrenaline, adrenaline, serotonin, vasopressin, angiotensin II, high potassium concentrations and sympathetic nerve stimulation constricted the vascular bed.4. Angiotensin I, bradykinin, histamine, acetylcholine and isoprenaline did not alter vascular resistance under baseline conditions.5. Maximal sensitivity to noradrenaline occurred at 32 degrees to 34 degrees C. Below 30 degrees C, resting tone increased and the pressor effect of noradrenaline was prolonged.6. Low concentrations of (+/-)-propranolol in the perfusate enhanced adrenaline and noradrenaline vasoconstriction, high concentration of (+/-)-propranolol had a direct pressor effect and did not affect catecholamine responses.7. The preparation is a simple and relatively inexpensive adjunct to established methods of studying resistance vessel behaviour under varying experimental conditions.


Gas chromatographic analysis of amines and other compounds produced by several species of Clostridium.


Some derivatives of polyvinylpyridine 1-oxides and their effect on the cytotoxicity of quartz in macrophage cultures. 1. Poly(2-vinylpyridine 1-oxide) counteracts the pathogenic effects normally produced when quartz is injected into or inhaled by animals and the cytotoxic effects when quartz is added to macrophage cultures. The protective action of this polymer has been attributed variously to the formation of an adsorbed layer on the quartz particles, complex formation with monosilicic acid produced by the dissolution of quartz, and strengthening of the membranes or microstructures of the cells.2. Stereoregular forms of poly(2-vinylpyridine 1-oxide), some alkyl derivatives of poly(2-vinylpyridine 1-oxide), poly(3-vinylpyridine 1-oxide) and poly(4-vinylpyridine 1-oxide), a copolymer of 2-vinylpyridine 1-oxide and 2-n-propenylpyridine 1-oxide, some poly(1-methyl-2-vinylpyridinium) quaternary salts, and poly(1-methoxy-2-vinylpyridinium iodide), which had previously been synthesized and studied with respect to their viscosities and interaction with silicic acid, were tested for their ability to counteract the cytotoxic effects of quartz in macrophage cultures. The tests were effected both by pretreating the quartz with polymers, and by pretreating the cells.3. Every polymer proved active in one or other of these conditions, but several were active in one test but inactive in the other. Some polymer quaternary salts, which do not contain the N-oxide group, were found to be active. A remarkable difference in activity was found between the two stereoregular forms of poly(2-vinylpyridine 1-oxide). Pretreatment of the quartz with some of the polymers increased its cytotoxicity significantly.4. Most of the results could be interpreted on the hypothesis that the polymers form an adsorbed layer on the quartz surface, but it is difficult to apply this explanation to two polymers which are inactive when used to pretreat the macrophages but are active when adsorbed on quartz.


Combined effect of salt concentration and redox potential of the medium on the initiation of vegetative growth by Clostridium welchii.


Anatomy of hereditary bovine syndactylism. II. Muscles, tendons, and ligaments.


Anatomy of hereditary bovine syndactylism. I. Osteology.


Anatomy of hereditary bovine syndactylism. 3. Angiology.


Anatomy of hereditary bovine syndactylism. IV. Neurology.


Parotid fluid steroid responses to ACTH and dexamethasone in Cushing's syndrome.


Light satellite-band DNA in mouse cells infected with polyoma virus.


Genetic influence on the renin-angiotensin system. Evidence for a renin inhibitor in hypertension-prone rats. TWO STRAINS OF RATS WITH OPPOSITE GENETIC PROPENSITY FOR HYPERTENSION WERE TESTED FOR: (a) the sensitivity to injections of angiotensin and renin, and (b) the influence of their plasma on the reaction velocity of renin and its substrate in vitro. Intact hypertension-prone (S) rats on low salt had higher sensitivity to angiotensin and a lower sensitivity to renin than hypertension-resistant (R) rats. High NaCl diet did not change the response of the R rats to these injections, but increased the response to renin and angiotensin in intact S rats. Bilateral nephrectomy caused increased response to renin and a decreased response to angiotensin in the S rats, so that both strains were equivalent after bilateral nephrectomy. In vitro, plasma from intact S rats inhibited the activity of hog renin. Plasma from R rats showed no inhibition. The inhibitor disappeared after bilateral nephrectomy. It was speculated that renin inhibitor may be involved in the development of hypertension by increasing sensitivity to angiotensin and other hypertensinogenic stimuli.


Granular-cell myoblastoma of the oral cavity.


Properties of mitochondria from hearts of cattle acclimatized to high altitude.


Histochemical study of digitoxin-phosphate-oil cardiopathy.


[Investigations on oncogenic transformation, induction of DNA-synthesis and t-antigen formation by UV-irradiated simian virus (SV-) 40].


Inter-relations between iron stores, general factors and intestinal iron absorption.


Periodic acid-Schiff reaction in human basophilic leucocytes.


Linear systems analysis of the Limulus retina.


Endocrinology and the systems paradigm.

Endocrinology and the systems paradigm.


Nonparticipation of transfer RNA in the biosynthesis of polymyxin B.


Chromatographic differences between lysyl-tRNA's from avian tumor virus BAI strain A and virus transformed cells.


Alteration in the ionic properties of aminoacyltransferase II from rat liver by NAD+ and diphtheria toxin.


DNA polymerase activities in Tradescantia paludosa pollen grain nuclei.


Intestinal parasites.

Intestinal parasites.


Granular cell myoblastoma.

Granular cell myoblastoma.


Enzymes of entamoeba histolytica.

Enzymes of entamoeba histolytica. In spite of extensive studies of the pathogenic activities of Entamoeba histolytica upon animal hosts by many investigators, the factors that govern the pathogenesis of the parasite are still largely unknown. Attempts have been made to determine the factors concerned in the pathogenicity of certain strains of E. histolytica from the aspect of parasite itself and from the point of view of its interaction with the host. The enzyme content of the trophozoites of the amoebae examined has been studied in detail, both in the living organism and in its extracts. The total patterns of proteolytic enzymes and of certain other enzymes were determined to establish whether it was possible to define the invasiveness of the various strains of E. histolytica already established as pathogenic by other workers or in our laboratories. It was found impossible to distinguish clearly between the so-called "pathogenic" and "non-pathogenic" strains of E. histolytica by such means.


Current concepts in the detection and treatment of the earliest of the early breast cancers.


Effect of vitamin A deficiency on 3beta-hydroxysteroid dehydrogenase activity and corticosterone in the rat adrenal.


Biosynthesis of labeled mouse tumor ACTH.


Role of the pituitary in controlling aldosterone production in sodium-depleted rats.


Persistence of label in rat offspring after maternal administration of a 14C-labeled inhibitor of 3beta-hydroxysteroid dehydrogenase.


Dibutyryl cyclic AMP, vitamin D and intestinal permeability to calcium.


Effect of pituitary and ACTH on the maintenance of basal tyrosine hydroxylase activity in the rat adrenal gland.


Requirement of Ca++ and Mg++ ions for the in vitro release of follicle-stimulating hormone from rat pituitary glands and in its subsequent biosynthesis.


Demonstration of membrane-linked iodoprotein in hepatic microsomes following metabolism of the thyroid hormones.


ACTH release evoked by electrical stimulation of brain stem and limbic system sites in the cat: The absence of ACTH release upon infundibular area stimulation.


Role of lecithin in the mechanism of TSH action.


Proteolysis in thyroid slices: Effects of TSH, dibutyryl cyclic 3', 5'-AMP and prostaglandin E.


ACTH, Corticosteroids and inhibition of protein synthesis.


Inhibition by thyrocalcitonin of the mitogenic actions of parathyroid hormone and cyclic adenosine=3',5'-monophosphate on rat thymocytes.


Histochemical study of isolated intratubular cells of the rat testis. II. Oxidases and dehydrogenases.


Histochemical study of isolated intratubular cells of the rat testis. I. Hydrolases and phosphorylase.


Dense core vesiculated axons in the renal portal valve of the domestic fowl.


Stimulation of corticosteroid secretion in man with a triazine derivative.


Herpes simplex virus infection in infants: a spectrum of disease.


Comparison of purified human and procine ACTH in man.


5-iodo-2'-deoxyuridine in neonatal herpesvirus hominis encephalitis.


Picrotoxin antagonism of the inhibition of interneurons by glycine.


Species difference in the structure of urinary 2-hydroxyestrone glucuronide.


A simplified determination of urinary testosterone utilizing column and gas-liquid chromatography. SAM-TR-68-117.


A study of the effect of ionizing radiation on resistance, germination, and toxin synthesis of Clostridium botulinum spores, types A, B, and E. COO-1095-3.


An improved procedure for separation of catecholamines from plasma.


Tumors of the marmoset produced by Rous sarcoma virus.


Structural and regulatory aspects of enzymes in chemotherapy.


Effects of ACTH, metopirone and dexamethasone on maternal urinary steroid excretion in late pregnancy.


Oxygen, uptake, transport, and tissue utilization.


Correlation between poliomyelitisvirus-reproduction-cycle, chromosomal alterations and lysosomal enzymes.


Effect of p-fluorophenylalanine on the replication of herpes simplex virus.


Enzymes of gluconeogenesis in tumor-bearing rats.


Purification of Sendai virus.

Purification of Sendai virus.


Studies on the pathogenesis of monkey pox. 3. Histopathological lesions and sites of immunofluorescence.


Studies on the pathogenesis of monkey pox. II. Dose-response and virus dispersion.


Hemagglutinin of vesicular stomatitis virus.


Homotypic and heterotypic interference among picornavirus ribonucleic acids.


A study of the interference phenomenon in vesicular stomatitis virus replication.


Chromatographic analysis of mixed populations of poliovirus.


Antiviral action of gliotoxin.

Antiviral action of gliotoxin.


An interferon-like inhibitor of foot-and-mouth disease virus induced by phytohemagglutinin in swine leukocyte cultures.


Differential sensitivity to gliotoxin of virulent and attenuated poliovirus strains and its possible use as a genetic marker.


Enhancement and neutralization of pyrogenicity of influenza viruses by various biologically active substances.


Poliovirus inhibition of the phytohemagglutinin response in human lymphocytes.


The development of neutralizing antibodies in guinea pigs following immunization with human cytomegalovirus.


Interaction of non-steroidal antiinflammatory agents with corticosterone binding to plasma proteins in the rat.


Effect of temperature on synthesis of T and V antigens of papovavirus SV 40 and induction of thymidine kinase.


Retardation of protein synthesis in rat tumours on inhibiting histamine formation.


Purines and cortisone in lipid mobilization.


The properties of neuraminidase-treated crystalline ceruloplasmin.


Dissociation of RNA-histone complexes by DNA.


An in vitro system for studying mucus secretion and other physiological activities in human intestinal mucosa.


Effect of sodium fluoride on the epinephrine response of liver and hepatoma adenyl cyclase.


Collagen substrate films for localizing collagenolytic activity histologically.


Intratypic differentiation of poliovirus strains of type I from pre- and post-vaccination groups.


Enteroviruses from cases of encephalitis in Pondicherry.


Observation on the intraluminal fluid obtained from rat uteri with an intrauterine device in one horn.


In vivo suppression of coding associated with bacteriophage-induced S-adenosylmethionine hydrolase. The methylation of ribosomal and transfer ribonucleic acid (RNA) synthesized after the induction of a hydrolase for S-adenosylmethionine by phage T3 infection is reducible to 50% of the methylation of RNA in uninfected cells. Hypomethylated ribosomal RNA is found in 70S particles that dissociate in 100 mum Mg(++) to yield only 30S and 50S subunits. By this criterion, the omitted methyl groups apparently are not required for ribosomal maturation or stability. The rate of production of alkaline phosphatase in a phosphatase amber mutant was examined after phage infection in the presence and in the absence of streptomycin to determine the effect on the translation process consequent to S-adenosyl-l-methionine (SAM) hydrolase induction. Significant increases in the rates of phosphatase production were found when ultraviolet-inactivated T3 or streptomycin was added. The effects were cumulative when the cells were treated with both bacteriophage and the drug. Ultraviolet-inactivated T7, a phage closely related to T3 but which does not produce the SAM hydrolase, did not enhance the rate of alkaline phosphatase production. We suggest that the production of SAM hydrolase affects the stability of the translation process by the observed hypomethylation or by mechanisms concerning polyamine metabolism.


Effect of nitrate, fumarate, and oxygen on the formation of the membrane-bound electron transport system of Haemophilus parainfluenzae. The composition of the membrane-bound electron transport system of Haemophilus parainfluenzae underwent modification in response to the terminal electron acceptor in the growth medium. H. parainfluenzae was able to grow with O(2), nitrate, fumarate, pyruvate, and substrate amounts of nicotinamide adenine dinucleotide (NAD) as electron acceptors. When O(2) served as the electron acceptor and its concentration was lowered below 20 mum, the bacteria formed more cytochromes b, c, a(1), a(2), and o than were present in the cells grown at 150 to 200 mum O(2). Nitrate and nitrite reductase activities also appeared during growth at the low O(2) concentrations in the absence of added nitrate. Cytochrome levels in cells grown anaerobically with fumarate, pyruvate, or NAD as terminal acceptors were similar to those formed in cells grown at low O(2) concentrations. Cells grown with nitrate had higher levels of cytochromes c, b, and o, and of nitrate and nitrite reductases, than did cells grown with the other acceptors. The formation of cytochrome oxidase a(2) was repressed by the presence of nitrate in the growth medium. The critical O(2) concentration (the O(2) concentration at which the rate of O(2) uptake becomes demonstrably dependent on the O(2) concentration) was about 100 mum in cells grown with nitrate and about 15 mum in cells grown with the other acceptors. A mutant of H. parainfluenzae was found to make about 10% as much cytochrome c as the wild type, and its formation of cytochrome a(2) was not repressed by nitrate. The critical O(2) concentration of the mutant was high when it was grown with nitrate, suggesting that the high levels of cytochrome c and the absence of cytochrome a(2) from the wild type are not responsible for the high critical O(2) concentration. The modifications of the respiratory system induced by changing the terminal electron acceptor were inhibited by the presence of chloramphenicol, which suggests that protein synthesis is involved.


Regulation of enzymes involved in the conversion of tryptophan to nicotinamide adenine dinucleotide in a colorless strain of Xanthomonas pruni. A colorless strain of Xanthomonas pruni was isolated which is capable of converting tryptophan to nicotinamide adenine dinucleotide (NAD). The enzymes responsible for the conversion of tryptophan to quinolinic acid were shown to be present. Nicotinic acid-requiring mutants were isolated, and it was found that the growth of these mutants can be supported by various intermediates on the pathway from tryptophan to NAD. The first three enzymes on this pathway are induced coordinately by l-tryptophan. Gratuitous inducers of these enzymes include d-tryptophan, alpha-methyl-dl-tryptophan, and 4-methyl-dl-tryptophan; formyl-l-kynurenine and l-kynurenine were not effective as inducers. These data suggest that at least the first three enzymes in the pathway from tryptophan to NAD are under common regulatory control.


Neuropathy: mono- or poly-?

Neuropathy: mono- or poly-?


Antibiotic acquistions in a 387-bed general hospital during 1960, 1965, 1967 and 1968.


Reidel's lobe of the liver.

Reidel's lobe of the liver.


Visual sensitivity.

Visual sensitivity.


The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I.


Interaction of N-methyl-N'-nitro-N-nitrosoguanidine with ascites hepatoma cells in vitro.


Mode of thyroxine action in the activation of glycogen synthetase of Rana catesbeiana tadpoles.


Adrenal corticosteroid involvement in the control of phosphorylase in muscle.


Equilibrium kinetic study of enzyme modifier action.


Adrenal corticosteroid involvement in the control of liver glycogen phosphorylase activity.


Enzyme-substrate kinetics associated with transient state conditions in single living cells.


An ATP-incorporating enzyme from rat brain. I. Solubilization and requirements.


Enzymatic dephosphorylation 3'-phosphoadenosine 5'-phoaphosulfate to adenosine 5'-phosphosulfate in sheep brain.


Liver microsomal inorganic pyrophosphate-glucose phosphotransferase and glucose-6-phosphatase. Effects of diabetes and insulin administration in kinetic parameters.


The effect of collagenase preparations contaminated with phospholipase C activity on adipose tissue lecithin.


Neurological complications of systemic diseases. I.


The role of hydrocyanic acid in nutrition.


Special service: friendly visitor.

Special service: friendly visitor.


Lymphocyte transformation in young people.


The distrubution of iron in iron-deficient toxin-synthesizing and in excess-iron non-toxin-synthesizing Corynebacterium diphtheriae.


Syndactylism with deformity of the pectoralis muscle. Poland's syndrome.


Radiology of the skull and central nervous system.


Clinical neurology.

Clinical neurology.


Psychosomatic medicine.

Psychosomatic medicine.


Isolation of Mycoplasma hominis, T-strains, and cytomegalovirus from the cervix of pregnant women.


The use of hyperbaric oxygen in the treatment of clostridial septicemia complicating septic abortion. Report of a case.


Inhibition of toad bladder responses to neurohypophysial hormones by (4-leucine)-oxytocin.


Pituitary-adrenal alterations and fear responding.


Absence of renin in kidneys of elasmobranchs and cyclostomes.


Probenecid inhibition of arginine vasotocin in snakes, frogs, and on frog bladders in vitro.


Cavitary bronchiolar carcinoma.

Cavitary bronchiolar carcinoma.


Effect of cord factor on carbohydrate metabolism in mice.


Streptomycin-induced neuromuscular fatigue in myasthenia gravis.


Glomus tympanicum tumor in an otosclerotic ear.


The influence of bradykinin and angiotensin on the muscularis of the digestive tract in experimental animals.


Transport of reduced nicotinamide-adenine dinucleotide into mitochondria of rat white adipose tissue. Mitochondria from rat white adipose tissue were prepared, exhibiting good respiratory control and P/O ratios. They would not oxidize NADH unless NNN'N'-tetramethyl-p-phenylenediamine was added as a carrier of reducing equivalents. These mitochondria were found to oxidize neither l-glycerol 3-phosphate nor l-glutamate plus l-malate at significant rates. The activity of aspartate aminotransferase in these mitochondria was found to be low compared with that found in rat liver mitochondria. As a consequence of this, the adipose-tissue mitochondria exhibited very low rates of cytoplasmic NADH oxidation in a reconstituted Borst (1962) cycle compared with liver mitochondria.


The role of the cytoplasmic redox potential in the control of fatty acid synthesis from glucose, pyruvate and lactate in white adipose tissue. The metabolism of lactate, pyruvate and glucose was studied in epididymal adipose tissue of starved, normally fed and starved-re-fed rats. Lactate conversion into fatty acid occurred at an appreciable rate only in the adipocyte of starved-re-fed animals. NNN'N'-Tetramethyl-p-phenylenediamine, an agent that transports reducing power from the cytoplasm to the mitochondria, caused large increments of fatty acid synthesis from lactate and a smaller one from glucose but a decrease in that from pyruvate. Glucose (1.0mm) increased fatty acid synthesis from lactate 4.3-fold but only 1.67-fold from pyruvate in adipocytes from normally fed animals. 2-Deoxyglucose decreased fatty acid synthesis from lactate to a greater degree (threefold) compared to that from pyruvate in adipocytes from starved-re-fed animals. l-Glycerol 3-phosphate contents were approximately equal in epididymal fat-pads, incubated in the presence of lactate or pyruvate, from normally fed animals, whereas the addition of 1mm-glucose resulted in a tenfold increase in l-glycerol 3-phosphate content only in the presence of lactate. The l-glycerol 3-phosphate content was tenfold higher in adipose tissue from starved-re-fed animals incubated in the presence of lactate than in the presence of pyruvate. 2-Deoxyglucose caused these values to be slightly lowered in the presence of lactate. We suggest that lactate metabolism is limited by the rate of NADH removal from the cytoplasm. In the starved-re-fed state, this occurs by reduction of dihydroxyacetone phosphate formed from glycogen to produce l-glycerol 3-phosphate, thus permitting lactate conversion into fatty acid. When glucose is the substrate, and rates of transport are not limiting, the rate of removal of cytoplasmic NADH limits glucose conversion into fatty acid.


Ubisemiquinone in membranes from Escherichia coli.


Effect of mercuric chloride on the arterial blood pressure of dogs.


On the nomenclature of asymmetrically substituted myoinositol derivatives with particular reference to phosphatidylinositols.


Enzyme activity determinations in bone and cartilage.


Some biochemical characteristics of rodent and human mammary carcinomas.


Silicic acid chromatography of organic acids in blood cells and biological fluids.


Disaccharidase content in the small-intestinal mucosa of normal mouse and of mouse with viral MHV-3 hepatitis.