Alcohol as an impurity in LADH preparations. Determination and removal.


Intestinal absorption and esterification of vitamin D3-1,2-3H in man.


Patient presentations: panel discussion. Arrhenoblastoma in a 13-year-old girl.


Ovarian tumors in infancy, childhood, and adolescence.


Evidence for confromational differences between oxidized and reduced cytochrome oxidase.


Hydrolysis of the polymer formed from NAD with rat liver phosphodiesterase yielding nucleoside 5'monophosphate.


A study of the action of angiotensin on the superior cervical ganglion in comparison with other ganglion stimulating agents.


Topical and remote effects of drugs upon tissue clearance.


On the question of the mechanism of inhibitory effect of acidosis on anaerobic glycolysis of erythrocytes.


The role of deoxyribonucleic acid in ribonucleic acid synthesis. 13. Modified purification procedure and additional properties of ribonucleic acid polymerase from Escherichia coli W.


Yeast aldehyde dehydrogenase. I. Purification and crystallization.


The enzymatic significance of S-acetylation and N-acetylation of 3-phosphoglyceraldehyde dehydrogenase.


The properties and enzymatic significance of the enzyme-diphosphopyridine nucleotide compound of 3-phosphoglyceraldehyde dehydrogenase.


Glycolytic control mechanisms. V. Kinetics of high energy phosphate intermediate changes during electrical discharge and recovery in the main organ of Electrophorus electricus.


Quantitative thin layer chromatography of lipids.


The effect of silicic acid and alkali concentration on the saponification of lipids.


A study of cholinoceptive cells in the lateral geniculate nucleus. 1. The dorsal lateral geniculate nucleus (LGN) of the cat stains densely for acetylcholinesterase, which is present in intra-axonal and extracellular locations.2. Acetylcholine (ACh), cholinomimetic drugs, anticholinesterases and ACh antagonists were administered iontophoretically to neurones in the LGN.3. ACh excited eighty-six of 184 (46.7%) geniculate neurones and depressed seven (3.8%).4. The excitatory response to ACh was frequently larger than that to L-glutamate and had a comparable time course.5. There was a considerable variation in the proportion of ACh sensitive cells in different animals. ACh firing was facilitated by optic nerve or visual stimulation.6. Carbamylcholine was the most active of the choline esters tested, frequently exceeding ACh in potency. The other choline esters and nicotine were consistently less active than ACh.7. Anticholinesterases, eserine, neostigmine and edrophonium potentiated the action of ACh, and often caused excitation. Eserine caused an initial small enhancement in the amplitude of the focal potential evoked by optic nerve stimulation followed by a reduction in amplitude and prolongation of duration of the potential.8. Atropine and benzoquinonium effectively prevented the ACh excitation of many cells. Dihydro-beta-erythroidine failed to cause a significant reduction in the magnitude of the ACh response. All three ACh antagonists failed to reduce the excitant effects of optic nerve or visual stimulation.9. Stimulation of the mesencephalic reticular formation caused either an enhancement or a reduction in the excitability of ACh sensitive neurones in the LGN. Benzoquinonium abolished the excitatory effects of reticular formation stimulation.10. The findings presented in this paper suggest that ACh is the transmitter released by terminals of nerves of the reticular formation projection to the LGN.


Neurohypophysial peptide interaction with magnesium in avian vascular smooth muscle. 1. The contractile responses of helically cut vascular strips of chickens to vasoactive agents were studied.2. Large pulmonary arteries were contracted by neurohypophysial peptides, but not by angiotensin, acetylcholine, histamine, 5-hydroxytryptamine, bradykinin or eledoisin. The activity of oxytocin was greater than that of arginine vasopressin.3. Vasodilator effects of oxytocin upon small (200-500 mu diameter) mesenteric and muscular arteries were demonstrable, but inconsistent.4. Magnesium potentiated in a parallel fashion the vasoconstrictor effects of oxytocin and of arginine vasopressin.5. Deamino-oxytocin was potentiated by magnesium. This finding suggests a difference between the peptide-protein interactions of tissue receptors and those of neurophysin.


The responses of thalamic neurons to iontophoretically applied monoamines. 1. The effects of noradrenaline (NA), adrenaline, dopamine (DA) 5-hydroxytryptamine (5-HT) and a number of related drugs were tested on the extracellularly recorded responses of neurones in the feline thalamus. Substances were applied iontophoretically and tested on synaptically, antidromically and chemically evoked neuronal activity.2. NA, adrenaline, isoprenaline and 5-HT had a variety of effects, depressing some cells, exciting others and not affecting the responses of a third group. DA depressed most of the cells tested; excitation was not observed with this compound.3. The magnitude of depressant actions and their duration varied considerably. The more sensitive cells responded to extremely small amounts of catecholamine or 5-HT and recovery often took several minutes. Recovery after DA was always rapid. Neurones in the dorsal thalamus were generally more susceptible to depression than those in the ventro-basal complex.4. Excitatory responses were most marked in the ventro-basal complex of the thalamus. Desensitization occurred if NA or adrenaline was applied repeatedly and this tachyphylaxis lasted for several minutes. After desensitization to the excitatory effects, some of these cells were depressed by catecholamines. These findings suggest the presence of at least two types of membrane receptor.5. beta-adrenergic antagonists (alderlin, D-INPEA and MJ 1999) and alpha-antagonists (phentolamine, dibenzyline and chlorpromazine) had pronounced depressant actions on some thalamic neurones. With the exceptions of D-INPEA and MJ 1999 they also excited cells that were excited by the catecholamines. Alderlin and phentolamine had both excitatory and inhibitory effects on some cells.6. The monoamine oxidase inhibitor, iproniazid, depressed neurones which were sensitive to NA depression. It did not appear to potentiate the effects of NA on most of the cells tested.7. Reticular formation stimulation depressed some neurones in the thalamus and excited others. The depressant effects of NA and reticular formation stimulation were reduced or abolished by an intravenous injection of picrotoxin (1 mg/kg).8. It is suggested that NA and 5-HT may be inhibitory transmitters in the thalamus, released at the terminals of ascending pathways from the brain stem that have been defined by fluorescence microscopy. The excitatory actions of these compounds may also be related to a synaptic role.


Overt herpes-T infection in squirrel monkeys (Saimiri sciureus).


The relative sensitivity to vibration of muscle receptors of the cat. 1. Longitudinal vibration was applied to the de-efferented soleus muscle of anaesthetized cats while recording the discharge of single afferent fibres from the proprioceptors within the muscle. Conditions were defined under which vibration can be used to excite selectively the primary endings of muscle spindles without exciting the secondary endings of muscle spindles or Golgi tendon organs.2. Frequencies of vibration of 100-500 c/s were used. The maximum amplitude of vibration which the vibrator could produce fell with increasing frequency; it was 250 mu (peak to peak) for 100 c/s and 20 mu for 500 c/s.3. Primary endings of muscle spindles were very sensitive to vibration. Most could be ;driven' to discharge one impulse for each cycle of vibration over the whole of the above range of frequencies, provided the initial tension was moderate (20-200 g wt.). The amplitude of vibration required to produce driving usually varied by less than a factor of two over the whole range of frequencies. The most sensitive endings could be driven by vibrations of below 10 mu amplitude.4. Stimulation of single fusimotor fibres, whether static or dynamic fusimotor fibres, increased the sensitivity of primary endings to vibration. Contraction of the main muscle, produced by stimulating alpha motor fibres, reduced the sensitivity of primary endings even when fusimotor fibres were also being stimulated.5. The secondary endings were very insensitive to longitudinal vibration and with the amplitudes available not one of twenty-five endings could be driven at 150 c/s or above; one ending could be driven at 100 c/s by vibration of 250 mu amplitude. Stimulation of single fusimotor fibres, probably all of which were static fusimotor fibres, made them slightly more sensitive to vibration but none of them approached the sensitivity of the primary endings.6. The Golgi tendon organs were as insensitive as the secondary endings when the muscle was not contracting and none could be driven at any frequency in spite of quite high tensions in the muscle. However, when the muscle was made to contract by stimulating alpha fibres in ventral root filaments the tendon organs became appreciably more sensitive, the degree of sensitization increasing approximately with the strength of the contraction. They never became as sensitive as the primary endings, and with the amplitudes of vibration available none was driven at frequencies of over 250 c/s.7. When the amplitude of vibration was somewhat below that required to produce driving of an ending it still produced some increase in its mean frequency of discharge. However, amplitudes of vibration of 25-50 mu applied to a non-contracting muscle, whether with or without fusimotor stimulation, produced driving of nearly all primary endings without any significant increase in the mean frequency of firing of secondary endings or Golgi tendon organs. Such vibration can therefore be used as a specific stimulus for the primary endings in order to investigate the central effects or repetitive discharge of the Ia afferent fibres from them.8. Experiments on endings in the peroneus longus muscle showed that these behaved similarly to those in soleus.


Concentrations of pyruvate kinase and lactate dehydrogenase in the kidney of the alloxan diabetic rat.


Hidradenoma of the vulva in pregnancy with recurrence after local excision.


Biochemical investigations of the actions of corticotrophins on the adrenal cortex.


Several aspects of the influence of vasopressin on pituitary-adrenal activity.


Corticotrophin stimulation tests.

Corticotrophin stimulation tests.


Some aspects of the pharmacology of metyrapone.


The assessment of hypothalamic-pituitary-adrenocortical function in man.


Evaluation of pituitary-adrenal function in man.


Effect of reserpine on prostate gland fructose.


Cushing's syndrome associated with a "corticotrophin"-producing bronchial neoplasm neoplasm  (results of corticotrophin assays and of pituitary-adrenal function tests).


Isoniazid-induced vitamin B6 deficiency. Metabolic studies and preliminary vitamin B6 excretion studies.


The Landry-Guillain-Barré syndrome. A survey and a clinical report of 127 cases.


Alveolar cells: protein biosynthesis.

Alveolar cells: protein biosynthesis.


Carcinoma of the trachea.

Carcinoma of the trachea.


Peripheral neuropathy in long-term diphenylhydantoin therapy.


Acrylamide poisoning.

Acrylamide poisoning.


Production of lung carcinomas in C57BL mice exposed to a cigarette smoke and air mixture.


Improving the psychiatric services.

Improving the psychiatric services.


Adrenocortical function in children with severe protein-calorie malnutrition.


Neural net analogs of rhythmic activity in the nervous system.


Stimulation and inhibition of adrenal RNA synthesis by ACTH.


Observations on the ultrastructure of a netastasizing beta cell islet tumor.


Interactions of adenosine tetraphosphate with myosin and actomyosin.


The binding of calcium at lipid-water interfaces.


Effect of glucocorticoids on nucleic acid metabolism of rat ascites hepatoma.


Chromosomal features in ascites and metastatic lesions of cancer clones.


Encephalomyocarditis virus infections in Florida, 1960-1966.


Mucinous adenocarcinoma of the bovine ovary.


Clinico-pathologic conference from the School of Veterinary Medicine, University of Pennsylvania.


The treatment of glioblastoma multiforme of the brain.


Radioisotope (gamma) cerebral angiography. Technical note.


Growth in mentally retarded children.

Growth in mentally retarded children.


Lymphangiography by lymph-node injection.


New electromechanical method for the assay of heparin in vitro.


The mechanism of staphylococcal alpha toxin action on smooth muscle.


In vitro incorporation of amino-acids into the contractile protein of human blood platelets.


New vasoconstrictor, bovine peptide B, released during blood coagulation.


Induction of tumours in hamsters with infectious canine hepatitis virus.


Mutation towards dextran sulphate resistance in type 1 poliovirus.


Electron spin resonance in biological tissues.


Radioimmunoassay of angiotensin in human plasma.


Pituitary-adrenal regulation of ceruloplasmin.


Inhibition of spinal neurons by glycine.


Acetylcholine, strychnine and spinal inhibition.


Pharmacological characteristics and ionic bases of a 2 component postsynaptic inhibition.


Increase in permeability of the postsynaptic membrane to potassium produced by 'nembutal'.


New observations regarding the auriculotemporal syndrome.


Bronchial neoplasm with endocrine, metabolic, and neurological manifestations. Report of a case.


Human infection with the virus of vesicular stomatitis during an epizootic.


Arborizing pulmonary embolization following lymphangiography. Report of three cases and an experimental study.


A critical evaluation of selective celiac and superior mesenteric angiography in the diagnosis of pancreatic diseases, particularly malignant tumor: facts and "artefacts".


Total-body opacification in the diagnosis of Wilms's tumor and neuroblastoma. A note of caution.


Viruses and chronic bronchitis.

Viruses and chronic bronchitis.


Effect of angiotensin on renal function of the dog.


Effect of triamterene on folic reductase activity and reproduction in the rat.


Recent developments in the understanding and teaching of educationally subnormal children in England and Wales.


A molybdate-activated phosphatase in arterio-venous anastomoses and in nerve ganglia satellite cells.


Adrenocortical cytogenesis in the adult male golden hamster. A radioautographic study using tritiated-thymidine.


Effects of dipyridamole on heart muscle mitochondria.


Major surgery in the presence of a primary capillary haemorrhagic disorder.


The thiamine pyrophosphatase technique as a indicator of morphology of the Golgi apparatus in the neurons. VI. Studies on the spinal cord, hippocampus, and trigeminal ganglion.


Radioisotope liver scans in pediatrics.

Radioisotope liver scans in pediatrics.


Experimental renal glomerulography.

Experimental renal glomerulography.


Hemorrhage in normal man: effect on renin, cortisol, aldosterone, and urine composition.


Quantitative studies of the bacterial flora of open skin wounds: the effect of topical antibiotics.


Syndactylism.

Syndactylism.


Maintenance in the community: a study of psychiatric after-care and rehospitalization.


Testing compliance with threshold limit values for respirable dusts.


Prognosis and treatment of idiopathic facial (Bell's) palsy.


The nature of the biochemical lesion in avian renal riboflavinuria. I. Effect of genotype on renal riboflavin metabolism.


Inhibition of renin release by vasopressin and angiotensin.


The response of the respiratory chain and adenine nucleotide system to oxidative phosphorylation in yeast mitochondria.


Radical transfer reactions and chemical protection in the dry state. Electron spin resonance studies on irradiated mixtures of ribonuclease and glycyl-glycine.


An evaluation of the Mitchell hypothesis of chemiosmotic coupling in oxidative and photosynthetic phosphorylation.


Acid phosphatase analysis in sea urchin eggs and blastulae.


Studies of phosphorus metabolism by isolated nuclei. IX. Nucleolar nucleosidediphosphatase activity.


Nearest neighbour base sequence analysis of the deoxyribonucleic acids of a further three mammalian viruses: Simian virus 40, human papilloma virus and adenovirus type 2.


Transformation of bovine cell cultures by preparations of polyoma virus.


Electrophoretic evidence for a single protein component in the capsid of polyoma virus.


Comparative growth and selection of small plaque and large plaque encephalomyocarditis virus in the absence of inhibitors from agar.


The mutability of small-plaque-forming encephalomyocarditis virus.


The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells.


The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture.


DNA polymerase induced by Simian virus 40.


Effect of actinomycin D on the synthesis of viral antigen in cercopithecus kidney cells infected with SV 40.


Nature of the inactivating action of trypsin on foot-and-mouth disease virus.


Experiences in laboratory diagnosis of herpes simplex, varicella-zoster, and vaccinia virus infections in routine medical practice.


A comparison of the lipolytic effects of beta-1-24-corticotropin and extracted porcine ACTH.


Renin-like enzyme in the adrenal gland.

Renin-like enzyme in the adrenal gland. The rabbit adrenal gland contains an enzyme which reacts with renin substrate to form a vasopressor polypeptide, probably angiotensin I. In view of the strong effects of angiotensin on secretion of aldosterone and catecholamine, this finding suggests that there may be an intra-adrenal mechanism for the control of adrenal secretions.


Effects of intra-arterial mepivacaine and bupivacaine on neuromuscular transmission in man.


Renal failure in patients with cirrhosis of the liver. 3. Evaluation of intrarenal blood flow by para-aminohippurate extraction and response to angiotensin.


Quadrivalvular rheumatoid heart disease associated with left bundle branch block.


The biosynthesis of phosphatidic acid and phosphatidylinositol in mammalian pancreas. 1. The labelling of guinea-pig pancreas phospholipids in vivo after intraperitoneal injection of [(32)P]orthophosphate is described. 2. Acyl-CoA synthetase activity in pancreas homogenates has been studied. There is no absolute requirement for added fatty acids, indicating an adequate supply of endogenous fatty acids in these preparations. 3. Phosphatidic acid is formed in guinea-pig pancreas preparations by two distinct routes, namely the acylation of l-3-glycerophosphate and the phosphorylation of 1,2-diglyceride. Phosphatidic acid formed by either mechanism is converted into phosphatidylinositol by guinea-pig pancreas in vitro. 4. The enzymes of pancreas that convert phosphatidic acid into phosphatidylinositol via CDP-diglyceride have been characterized. 5. Addition of bovine serum albumin is necessary in assaying certain of these enzymes.


Measurements of tryptophan pyrrolase in vivo: induction and feedback inhibition.


Influence of temperature acclimatization on the temperature-dependence and ouabain-sensitizing of goldfish intestinal adenosine triphosphatase. 1. Homogenates of goldfish intestinal mucosa were separated into various fractions by differential centrifugation. Both adenosine-triphosphatase and beta-glycerophosphatase activities were found to be concentrated mainly in a membrane fraction which sedimented after 1200000g-min. 2. This membrane adenosine-triphosphatase system was activated by Na(+)+K(+) and inhibited by ouabain. 3. The ouabain-sensitive adenosine-triphosphatase activity was high and the ouabain-insensitive activity low in membrane fractions prepared from fish acclimatized previously to 8 degrees . The opposite was true for fish acclimatized to 30 degrees . 4. The Arrhenius plots of ouabain-sensitive and ouabain-insensitive adenosine-triphosphatase activities, measured from 5 degrees to 30 degrees , showed discontinuities at incubation temperatures that varied with the previous acclimatization temperature of the fish. 5. It is considered that modification of the membrane adenosine-triphosphatase system in goldfish intestinal mucosa may serve to regulate Na(+) transport at different environmental temperatures.


The binding of adenine nucleotides to the mannitol-I-phosphate dehydrogenase of Escherichia coli.


Starch-gel investigations of the relationships between dehydrogenase proteins.


Chemical modification of aminoacyl ligases and the effect on formation of aminoacyl-tRNA.


Some aspects of the apparent glucose-6-phosphatase activity in the pancreatic islets of mammals.


Derepression of phosphomonoesterase and phosphodiesterase activities in Aerobacter aerogenes.


Electrophoretic variants of xanthine dehydrogenase in Drosophila melanogaster. II. Enzyme kinetics.


The enzymatic reduction of ferrihemoglobin. I. The reduction of ferrihemoglobin in red blood cells and hemolysates.


The role of the adrenal medulla in the hypoglycemia of foetal malnutrition.


Plasticizers in medical application. I. Analysis and toxicity evaluation of dialkyl benzenedicarboxylates.


Plaque assay of the effects of cytosine arabinoside and 5-iodo-2'-deoxyuridine on the synthesis of H-I virus particles.


Organospecificity of liver cell surface antigens and its loss by ascitic hepatoma.


Investigation of albumin metabolism in man.


Corticotrophin secretion in patients with head injuries examined by the metopirone test.


Molecular pathology and carcinogenesis.

Molecular pathology and carcinogenesis.


Some psychologic considerations in the medical management of ulcerative colitis.


Foot-and-mouth disease.

Foot-and-mouth disease.


Study uncovers 'unnecessary' long-term stays in a short-term hospital.


Activities of various steroidogenic enzymes in two forms of experimental adrenal hyperplasia.


Projection of growth.

Projection of growth.


Spectrum of human cytomegalovirus complement-fixing antigens.


Rubella virus: role of interferon during infection of African green monkey kidney tissue cultures.


Studies on bovine glomeruli. II. Localization of glomerular collagen.


Experimental study on chronic viral hepatitis in mice.


Muscular dystrophy associated with intermittent peripheral neuropathy.


A new fixative and technics for the diagnosis of intestinal parasites.


Intrauterine and neonatal infections under immature antibody formation system.


Comparison of glycolytic enzyme activities in a series of human and rodent hepatomas.


The molecular correlation concept of neoplasia.


Benign synovioma.

Benign synovioma.


Corticosteroid therapy in children with asthma. Hypophyseo-adrenocortical inhibition.


Cushing's syndrome associated with an islet-cell tumour of the pancreas in a boy aged 2 years.


On the theory of silicosis. 3. Stishovite.


Some aspects of cancer in childhood.

Some aspects of cancer in childhood.


Food-associated viruses.

Food-associated viruses.


Clostridium perfringens and other bacterial species as possible causes of foodborne disease outbreaks of undetermined etiology.


Estimation of mammalian collagenolytic activity with a synthetic substrate.


The effect of nicotinamide adenine dinucleotide and rotenone on the oxidation of choline by rat liver mitochondria.


The detection and characterization of several conformational states of cytochrome b5 aporeductase during reversible denaturation.


The amino acid sequence of an extracellular nuclease of Staphylococcus aureus. II. The amino acid sequences of tryptic and chymotryptic peptides.


The amino acid sequence of an extracellular nuclease of Staphylococcus aureus. 3. Complete amino acid sequence.


The interaction of nucleotides with the active site of staphylococcal nuclease. Spectrophotometric studies.


An improved method for the purification of staphylococcal nuclease.


Pathogenesis of the postcardiotomy syndrome.


Granular cell myoblastoma of the oesophagus--a report of 2 cases.


Radiography in malignant tumors of paranasal sinuses with beginning exophthalmos.


Aggressive approach to the treatment of Wilms' tumor.


Recurrent Cushing's disease and intermittent functional adrenal cortical insufficiency following subtotal adrenalectomy.


Lipid cell tumors of the ovary.

Lipid cell tumors of the ovary.


Febrile mucocutaneous syndrome with respiratory involvement, associated with isolation of Mycoplasma pneumoniae.


Neurogenous tumors of the head and neck.


Multiple granular cell tumors ("myoblastomas"). Case report with electron microscopic observations and review of the literature.


The determination of the urinary excretion of 11-oxy-17-ketosteroids in normal human individuals and in patients with rheumatoid arthritis.


Intranuclear inclusion disease of pigeons.


Studies on cytochrome a. XVII. Analogy and distinction between the cyanide complex and the so-called "cytochrome a" free from cytochrome a3.


The effect of rotenone on the regulation of fatty acid synthesis in heart mitochondria.


The isolation of 4-thiouridylate disulfide from oxidized transfer ribonucleic acid of Escherichia coli.


Purification and properties of chicken liver xanthine dehydrogenase.


Differential effects of palmityl coenzyme A on liver microsomal inorganic pyrophosphate-glucose phosphotransferase and glucose 6-phosphate phosphohydrolase.


Models for cooperative effects in proteins containing subunits. Effects of two interacting ligands.


Enzymatic breadage and joining of deoxyribonucleic acid. 3. An enzyme-adenylate intermediate in the polynucleotide ligase reaction.


On the subunit structure of ribonucleoside diphosphate reductase.


The reaction of liver alcohol dehydrogenase with reduced diphosphopyridine nucleotide.


Radioautography with tritiated thymidine in measles and Sendai virus-induced chromosome pulverizations.


Radioimmunoassay of beta-MSH in human plasma and tissues. A radioimmunoassay method for beta-melanocyte-stimulating hormone (beta-MSH) has been developed and utilized in the identification and quantification of this hormone in human plasma and tissues. The concentration of beta-MSH in two human pituitary glands was found to be approximately 350 mug/g. beta-MSH was identified in the tumor tissue of all 11 patients with the ectopic ACTH syndrome who were studied; concentrations in individual cases ranged from 3 to 1600 ng/g. In plasma of chronically hyperpigmented patients with Addison's disease, Cushing's disease (after bilateral adrenalectomy), and the ectopic ACTH syndrome, beta-MSH concentrations of 0.5-6 ng/ml were found. The degree of clinical hyperpigmentation was well correlated with the quantity of beta-MSH in the plasma. beta-MSH concentrations in the plasma of normal subjects were less than 0.09 ng/ml. In all of these circumstances, bioassays for MSH were also performed, and it was found that most of the biologic MSH activity of the plasma and tissues could be accounted for by beta-MSH.


Effects of adrenergic receptor activation and blockade on the systolic preejection period, heart rate, and arterial pressure in man. We have investigated the possibility that alterations in the duration of the systolic preejection period can be used to estimate adrenergic influences on the human left ventricle. The preejection period was determined from high speed, simultaneous recordings of the phonocardiogram, carotid pulse tracing, and electrocardiogram. The preejection period was shortened by isoproterenol, epinephrine, and moderate doses of norepinephrine-all of which activate beta adrenergic receptors-and by cedilanid-D. It was unaltered by changes in heart rate induced by atropine and right atrial electrical pacing. Beta adrenergic receptor blockade by propranolol abolished the shortening effects of the three catecholamines but did not inhibit that due to cedilanid-D. Vasoconstriction, both alpha adrenergic (epinephrine and norepinephrine after propranolol) and nonadrenergic (angiotensin), prolonged the preejection period. Most of the shortening of the preejection period by beta adrenergic receptor activating agents and cedilanid-D and all of the prolongation accompanying pharmacologic vasoconstriction occurred after the onset of the first heart sound, thereby excluding changes in electrical-mechanical delay as a major factor in the observed preejection period responses. Shortening of the preejection period by beta adrenergic activity induced with isoproterenol was dose-related. Increasing doses of propranolol produced parallel shifts to the right in the isoproterenol dose-response curve. In 37 normal resting subjects intravenous propranolol (10 mg) prolonged the preejection period an average of 10 (SE +/- 1) msec. In six patients with psychogenic sinus tachycardia and a patient with a pheochromocytoma the presence of excessive beta adrenergic influences on the left ventricle was demonstrated by the finding of an initially short preejection period which responded with an abnormally great prolongation to beta adrenergic receptor blockade.


A possible role for the adenylcyclase system in insulin secretion. A possible role for adenylcyclase in insulin secretion was investigated. Isoproterenol, a predominantly beta-adrenergic agent, when mixed with an alpha-adrenergic blocking agent (phenoxybenzamine), stimulated insulin secretion from pieces of the rat's pancreas in vitro. Theophylline, caffeine, 3'5'-cyclic AMP, glucagon, adrenocorticotropin (ACTH), and thyrotropin (TSH), all of which are thought to act through the adenylcyclase systems in the liver and adipose tissue, also stimulated insulin secretion in vitro; oxytocin and vasopressin, which do not stimulate lipolysis in adipose tissue, were inactive. In all cases, stimulation of insulin secretion could not be detected when glucose was absent or present in only low concentrations (less than 100 mg/100 ml) and was maximal at high levels of glucose (300 mg/100 ml). When pancreatic tissue was obtained from normoglycemic rats and contained no detectable glycogen in the Islets, the stimulant effects of glucose and of theophylline were reduced or abolished by mannoheptulose and 2-deoxyglucose. When tissue was derived from rats infused for 8-10 hr with glucose and contained glycogen, theophylline, even in the absence of glucose, stimulated secretion and this effect was reduced by 2-deoxyglucose but not by mannoheptulose. It is suggested that the beta-cell contains an adenylcyclase system through which phosphorylase and possibly phosphofructokinase could be activated; and that insulin secretion could depend upon and be regulated by hormones and other substances which influence the rate at which glycolysis proceeds within the beta-cell.


Inhibition of the activity of alpha-toxin of Clostridium perfringens by toxic filtrates of corynebacteria.


Cytochrome oxidase repair during treatment of copper deficiency: relation to mitochondrial turnover. The repair of cytochrome oxidase depletion during the treatment of copper deficiency was studied in the rat. The purpose of this study was to distinguish the role of new cell production from the possibly more specific role of mitochondrial turnover in determining the rate of this repair. In rats on a copper-deficient regimen until 2.5-3 months of age, activities of cytochrome oxidase expressed as per cent of control were as follows: skeletal muscle (quadratus lumborum), 18%; heart, 27%; liver, 34%; and intestinal mucosa, 34%. After 2-3 days of dietary supplementation with cupric acetate, repair of decreased cytochrome oxidase activity in intestinal mucosa is complete. Histochemical studies indicated that this repair starts in the newly differentiating cells at the base of the villus and then progresses toward the tip of the villus at a rate approximating the normal rate of migration of the mucosal cells. In liver and skeletal muscle, cytochrome oxidase activity returned to control values after 10-15 days of treatment with cupric acetate. In heart muscle, control values were approached more slowly as indicated both by activity of the enzyme and by mitochondrial difference spectra which reflect enzyme concentration. Although cytochrome oxidase repair in the intestine appeared to be limited by the rate of production of new mucosal cells, the rate of repair in liver and skeletal muscle was several times too rapid to be accounted for by known rates of new cell production. Incorporation of tritiated thymidine into DNA in these tissues in both the deficiency state and during repair indicated no major differences in new cell production compared to that of control animals. However, the time required for cytochrome oxidase repair in liver was similar to the turnover reported for other mitochondrial constituents in this tissue. The rate of cytochrome oxidase repair may therefore be more directly determined by the rate of synthesis of new mitochondrial material than by the rate of production of new cells.


The presence of ECHO 9 antibodies in the young population of different regions in Serbia.


The isolation of cytopathogenic enteroviruses from the sewage in Moscow and the Moscov District in 1963-1964.


Treatment of pulmonary tuberculosis.

Treatment of pulmonary tuberculosis.


Irradiation stricture of small and large intestine simulating recurrence  of neoplasm.


Inhibitory action of sodium ions on transmitter release at the motor end-plate.


Urinary excitatory postsynaptic potentials in Clarke's column neurons.


Influence of denervation on localization of neurotoxins from clapid venoms in rat diaphragm.


Effect of chlordiazepoxide on stomach ulcers in rabbit induced by stress.


Association of AAV-1 with simian adenoviruses.


Incorporation of C14-choline and tritiated inositol into rat adipose tissue phospholipid in vitro.


Mechanism of the toxic effects of hyperbaric oxygen.


Adrenergic innervation of the human female reproductive organs: a histochemical and chemical investigation.


The biochemical development of surface activity in mammalian lung. I. The surface-active phospholipids; the separation and distribution of surface-active lecithin in the lung of the developing rabbit fetus.


Tar and grease removal from injured parts.


The murine leukemia-sarcoma virus complex.


Cryosurgery in otolaryngology.

Cryosurgery in otolaryngology.


Mechanism of ribulose-diphosphate carboxydismutase reaction.


In vitro cultivation and immunofluorescent studies of transplantable carcinomas Vx2 and Vx7. Persistence of a Shope virus-related antigenic substance in the cells of both tumors. The Vx2 and Vx7 rabbit carcinomas, both of Shope papilloma derivation, were cultivated in vitro and studied for immunofluorescence indicative of the presence of viral antigen. The cultured Vx7 cells were characteristically pleomorphic, round or polygonal cells, and immunofluorescence was demonstrable in 5-20% of them as counted on cover slip cultures after exposure to rabbit sera containing anti-Shope papilloma virus antibody. The Vx2 cells in contrast to this were of almost uniform size and character, small and approximately round, and the specific fluorescence was found in less than 0.1% of the total number. These findings indicate that some antigenic derivation from the Shope papilloma virus is still persisting at least in some fractions of the cells, not only of Vx7 tumors but also of the Vx2 tumors, even after maintenance of the growths by transplantation for more than 20 yr. During the course of the study, two lines of the Vx7 were kept continually growing while the culture of Vx2 was discontinued at its tenth passage after an accident due to mechanical failure of the incubator. The neoplastic capacity of the Vx7 cells cultured in vitro was demonstrated by implanting these intradermally on the ears of domestic rabbits. The result was destructive carcinomas of the Vx7 sort.


Studies on the mode of action of diphtheria toxin. 3. Site of toxin action in cell-free extracts. Extracts from HeLa cells treated with excess diphtheria toxin for several hours, until all protein synthesis has been arrested, are still able to stimulate the poly U-directed incorporation of phenylalanine into polypeptides at a moderate rate. Activity may be restored to normal levels or above by addition of a soluble enzyme fraction containing transferase II. Our results are in agreement with those of Collier who has recently shown that toxin inactivates transferase II in extracts from rabbit reticulocytes. We have further demonstrated that amino acid incorporation in extracts from intoxicated HeLa cells is limited by their transferase II content whereas, in extracts from normal cells, it is the ribosomes and to a lesser extent sRNA that are limiting. We have found that only soluble transferase II is inactivated by toxin; the ribosome-bound enzyme is resistant.


Studies on the mode of action of diphtheria toxin. IV. Specificity of the cofactor (NAD) requirement for toxin action in cell-free systems. The ability of a number of nucleotides related to NAD to replace NAD as cofactors for inhibition by diphtheria toxin of peptide bond formation has been examined. Neither NADH nor NADP are active. Of some 14 analogues closely related structurally to NAD that have been tested, only 3-thiocarboxamide pyridine-AD is as active as NAD itself. Replacement of the 3-carboxamide group on the pyridine ring by an acetyl group, or deamination of the purine ring, resulted in derivatives with reduced activity. The results were interpreted as suggesting that NAD and certain related nucleotides are capable of specific interaction with diphtheria toxin. Using the method of equilibrium dialysis, reversible binding of 1 mole of NAD per mole of toxin has been demonstrated. Toxoid does not interact with NAD.


Evaluation of ascorbic acid as an adrenal scanning agent.


Thymic function and carcinogenesis.

Thymic function and carcinogenesis.


Studies on the mode of action of diphtheria toxin. V. Inhibition of peptide bond formation by toxin and NAD in cell-free systems and its reversal by nicotinamide. Inhibition of soluble transferase II activity in cell-free systems by diphtheria toxin and NAD can be prevented or reversed in the presence of a sufficient concentration of nicotinamide. Quantitative studies on inhibition of peptide bond formation in cell-free extracts by toxin and NAD have indicated that two successive reversible reactions are involved. First, toxin and NAD interact mole for mole to form a relatively dissociable complex. This toxin-NAD complex then reacts with transferase II to form an enzymatically inactive product that is but slightly dissociated. In the presence of sufficient nicotinamide, however, the latter complex can be broken down to yield active transferase II once more. Based on the above model, an equation has been derived that accurately predicts the per cent inhibition of amino acid incorporation in cell-free systems at any given toxin and NAD level. The observed inhibition appears to be independent of the sensitivity to toxin of the cell species from which the extracts were derived, and depends only on the toxin and NAD concentrations. Although the model satisfactorily explains inhibition of peptide bond formation by toxin in cell-free systems, further assumptions are needed to explain how still lower concentrations of toxin are able to arrest protein synthesis completely in the living cell.


Psychotropic drugs and neurohumoral substances in the central nervous system.


The effect of vitamin A on myxoviruses. II. Alterations in the lipids of influenza virus.


Group-specific antigen of avian leukosis viruses. Virus specificity and relation to an antigen contained in Rous mammalian tumor cells.


Enhanced diffusion of enterovirus antigens in agar gel in the presence of protamine.


Renal function during exercise. With special reference to exercise proteinuria and the release of renin.


Enzymes of the accessory boring organ of the muricid gastropod Urosalpinx cinerea follyensis. I. Aerobic and related oxidative systems.


Cardiac effects of hayatin methochloride & other histamine releasers.


Medical quackery.

Medical quackery.


Isotopic determination of histidine decarboxylase: a disposable assay vial.


Angiographic diagnosis of the character of cerebral gliomas.


Studies with a multichannel flame spectrometer. 3. Simultaneous analysis of magnesium, calcium, copper, manganese, and chromium: a method devoid of cation and anion interferences.


Studies on the use of ACTH in multiple sclerosis.


Hydrogen transfer into mitochondria in the metabolism of ethanol. I. Oxidation of extramitochondrial reduced nicotinamide-adenine dinucleotide by mitochondria.


Kethyl activation and sRNA methylation by soluble fractions of several vertebrate livers.


Ferrous iron oxidation by Ferrobacillus ferrooxidans. Purification and properties of Fe++-cytochrome c reductase.


Mechanism of Fe++-cytochrome c reductase of Ferrobacillus ferrooxidans.


New 1,2-disubstituted benzimidazoles with high inhibiting effects on poliovirus replication.


The effect of ammonium ion upon ribonucleic acid polymerase and guanidine triphosphatase activity in isolated bovine endometrial nuclei.


The oxidation-reduction state of pyridine nucleotide in isolated frog gastric mucosa.


Metabolism of pyridoxal phosphate in the liver of hypo- and hyperthyroid rats.


Increased pressor responsiveness to kidney extracts.


Influence of heavy water (D2O) on the multiplication of adeno and Mengo virus.


Virogenic lines of RSV-transformed rat cells.


The aldosterone-renin constellation in Conn's syndrome.


Congenital malformation of the heart with inclusion body disease--report of four autopsy cases.


Median and ulnar neuropathy in the guinea-pig.


Phrenic nerve conduction in man.

Phrenic nerve conduction in man.


Experimental vascular lesions elicited by collagenase in rats.


Electronic aspects of carcinogenesis.

Electronic aspects of carcinogenesis.


Biological and physical properties of leukemogenic agent of a new type of viral murine leukaemia. 1. Sensitivity of other mouse strains and other species to the virus, titration of the virus, influence of a temperature on leukemogenic activity.


Serum and liver beta-glucuronidase activity in the course of experimental hepatocancerogenesis induced by diethylnitrosamine in mice.


The rhinoviruses.

The rhinoviruses.


Radiolysis of solid L-alpha-alanine.

Radiolysis of solid L-alpha-alanine.


Electron spin resonance spectra of an irradiated single crystal of L-alpha-alanine at 77K.


Magnetic resonance studies of met-myoglobin and myoglobin azide.


Spermatogenesis in animals as revealed by electron microscopy. XVI. The microtubular structure and sites of thiamine pyrophosphatase activity in premature sperm of the Japanese crayfish.


Effect of enhancer on the replication of newcastle disease virus in chorioallantoic membranes.


The structure of infectious bovine rhinotracheitis virus.


Complement-fixing antibodies in mammals bearing Rous sarcoma.


Properties of ATP-ase of the BAI strain A virus. I. Characterization of the enzyme from the point of view of activation and inhibition, and a comparison of its properties with those of ATP-ases of the structural components of the leukaemic myeloblast.


Properties of ATP-ase of the BAI strain A virus. II. Properties of binding of ATP-ase to cell structures and its substrate specificity.


The effect of intracellular current pulses in smooth muscle cells of the guinea pig vas deferens at rest and during transmission. The effect of intracellular current pulses on the membrane of smooth muscle cells of the guinea pig vas deferens at rest and during transmission was studied. Two main response types were identified: active response cells, in which a spike was initiated in response to depolarizing currents of sufficient strength and duration; passive response cells, in which depolarizing currents gave only electrotonic potential changes. These cells were three times more numerous than the active response cells. During the crest of the active response the input resistance fell by about 25% of the resting value. Comparison of the active response with the action potential due to stimulating the hypogastric nerve showed that the former was smaller in amplitude and had a slower rate of rise and higher threshold. Electrical coupling occurred between the smooth muscle cells during the propagation of the action potential. Depolarizing current pulses had no effect on the amplitude of the excitatory junction potential (E.J.P.) in passive response cells, but in general did decrease its amplitude in active response cells. These results are discussed with respect to the mechanism of autonomic neuroeffector transmission.


The contractile and control sites of natural actomyosin. The various contractile and control sites of natural actomyosin gel were studied by comparing the kinetics of ATP hydrolysis with those of gel contraction, measured as an increase in turbidity. Contraction of actomyosin gel seems to require the cooperative reaction of ATP (with Mg) at two different sites. One of these sites catalyzes the hydrolysis of ATP and most probably contributes the driving force for contraction; the binding of ATP to the other site appears to break certain links that retard movement of the gel components. At limiting concentrations of ATP, the rate of contraction seems to depend on the rate of breaking these links as well as on the rate of ATP hydrolysis. But when both sites are saturated, the rate of contraction appears to be limited only by the rate of ATP hydrolysis. In addition to these two contractile sites, there are also two different control sites. At one, the relaxing site, the binding of ATP with Mg inhibits ATP hydrolysis and gel contraction. At the other, the binding of calcium activates contraction by overcoming the inhibitory action of Mg and ATP at the relaxing site. This control system-inhibition by substrate and disinhibition by calcium-can be selectively inactivated by heat and reactivated by dithiothreitol, a disulfide-reducing agent. These observations on the isolated contractile system are discussed in relation to the contraction and relaxation of muscle.


Correlated biochemical, histochemical and electron microscopic studies on fiber types in striated muscles of rat.


Shortening-inhibition of prime movers. A safety factor in mastication.


Carbon dioxide fixation and phosphoenolpyruvate carboxylase in Ferrobacillus ferrooxidans.


Effect of sodium pyrophosphate on experimental soft-tissue calcification and hypercalcemia.


Modification of hexobarbital metabolism by Morris hepatoma 5123tc.


Oriented overgrowth (epitaxy) of macromolecular organic compounds.


On the reduced minus oxidized difference spectrum of P-450 in liver microsomes.


Floridean starch of a calcareous red alga, Joculator maximus.


Subcellular distribution of P-450 in bovine corpus luteum.


Rotenone and amytal insensitive coupled oxidation of NADH by mitochondria from Aspergillus niger.


Testosterone metabolism by the chicken uropygial gland.


Problems related to the determination of the secretion and interconversion of androgens by "urinary" methods.


Nycthemeral rhythm of plasma cortisol levels in the Cushing's syndrome associated with hyperplasia of adrenal cortex, before and after treatment of hypophyseal suppression with ultrasonic technique.


Studies on polypeptides. 38. Elimination of the histidine residue as an essential functional unit for biological activity of beta-corticotropin.


Spectroscopic models related to coenzymes and base pairs. I. The basis for hypochromism in the ultraviolet spectra of model systems related to nicotinamide--adenine dinucleotide.


The enzymatic preparation of isolated intact parenchymal cells from rat liver. Suspensions of isolated parenchymal cells were prepared from rat liver by incubation with collagenase and hyaluronidase followed by mechanical treatment. Utilization of 0.15% collagenase together with 0.15% hyaluronidase yielded adequate numbers of cells for experimental purposes. As shown by light and electron microscopy, approximately 75% of the isolated cells retain their structural integrity. The cell suspensions are capable of maintaining endogenous respiration in the presence of 1% albumin for periods of time up to 8 hr. These cell preparations consist almost entirely of parenchymal cells and offer a unique tissue preparation for the study of hepatic metabolism.


Electron microscopic examination of subcellular fractions. II. Quantitative analysis of the mitochondrial population isolated from rat liver. Large granule fractions, containing about 80% of the cytochrome oxidase of the tissue, were isolated from rat liver and used to prepare thin pellicles of packed particles which were submitted to quantitative electron microscopic examination. Various parameters describing the mitochondrial population were determined by measuring the size and number of mitochondrial profiles in sections, and the ratio of the inner to the outer membrane area. The mean particle radius and volume were found to be respectively 0.38 micro and 0.29 micro(3); the average areas per mitochondrion were 2 and 5 micro(2) for the outer and inner membranes respectively. On the basis of the cytochrome oxidase activity recovered in the particulate fractions, the results were extrapolated to the whole liver, and it was concluded that rat liver contains about 5.10(11) mitochondria per gram; this corresponds to a volume of 0.14 ml/g and to an area of 2.5 and 1 m(2)/g for the inner and outer membranes respectively. The validity and the accuracy of these determinations is discussed and the results are compared to the information which has been obtained by independent methods or by other investigators.


A study of some motile group D streptococci.


Pleomorphic adenoma. Report of a case.

Pleomorphic adenoma. Report of a case.


Size, score and speed of development of tumors in chickens in response to subcutaneous inoculations with Rous sarcoma virus.


The utilization of phytate phosphorus by poultry--a review.


Characterization of five isolates of Marek's disease.


The influence of cortisone and low environmental temperature on experimental infectious canine hepatitis in the guinea-pig.


Pathology of extranasal lesions in experimental inclusion-body rhinitis of pigs.


Observations on the origin and genesis of a rapid sympathetic rhythm.


Some properties of prostaglandin E1 action on muscle.


Control of NADH oxidation by ADP in membranes from Mycoplasma laidlawii.


Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis.


Metabolism of phospholipids. X. Partial purification and properties of a soluble phosphatidate phosphohydrolase from rat liver.


Concentrations and disappearance post mortem of polyphosphoinositides in developing rat brain.


Polymerization of the adenosine 5'-diphosphate-ribose moiety of nicotinamide-adenine dinucleotide by nuclear enzyme. I. Enzymatic reactions.


Bovine aorta ribonuclease.

Bovine aorta ribonuclease.


Turnover of ribosomal RNA in a ribonuclease I-less mutant of Escherichia coli, Q-13, which was found to possess polynucleotide phosphorylase.


Evidence that a rat liver "inhibitor" of the synthesis of DNA in cultured mammalian cells is arginase.


Lipids of subcellular particles from bovine heart muscle. I. Fatty acids of neutral lipids.


Family interaction in schizophrenia.

Family interaction in schizophrenia.


Renin content of the rat kidneys after prolonged treatment with formalin or ACTH.


Changes in cytochrome oxidase activity of the isolated perfused rabbit kidney.


Lysosomal damage in various phases of mouse viral hepatitis.


Porcine nephroblastoma.

Porcine nephroblastoma.


The synthesis and properties of analogues of angiotensin modified in the 1- or the 4-position.


Acute hemolytic anemia complicating infectious mononucleosis: the mechanism of hemolysis.


Histochemistry of the mesonephros in the developing chick.


Radiation studies on mice of an inbred tumor-resistant strain. V. Possible evidence for activation of the mammary tumor virus (MTV) by urethane as observed by electron microscopy.


Esterase activity in the green alga Trebouxia.


Platelet enzymes.

Platelet enzymes.


Altered synaptic terminals in cortex near tumor.


Ocular complications of vincristine therapy.


Electron microscopic study of the mouse leukemia virus (Gross) in organs of mouse embryos from virus-injected and normal C3Hf parents.


The effect of gonadectomy on the development of hepatomas induced by urethan.


Basophil adenomata in the pituitary glands of 2-year-old male Long-Evans rats.


Histologic features of virus-rich and virus-poor Shope papillomas of cottontail rabbits.


Localization of tumor antigens in adenovirus-12-induced tumor cells and in adenovirus-12-infected human and hamster cells by ferritin-labeled antibodies.


Tumor production in vivo and cell transformation in vitro by two SV20 strains.


Hepatocarcinogenicity of griseofulvin following parenteral administration to infant mice.


Deoxycytidylate deaminase activity of simian virus 40-infected cell cultures.


Vaccarezza's test. Its use in the presumptive diagnosis of cancer.


Serum proteins in pulmonary tuberculosis.


Carcinoma of the lung in Iceland.

Carcinoma of the lung in Iceland.


Production of steroids by in vitro superfusion of endocrine tissue. I. Apparatus and a suitable analytical method for adrenal steroid output.


Neurohumoral transmission and neuropsychiatric disorders.


Cell-sensitizing products of streptococci.


Pneumonia in the older patient.

Pneumonia in the older patient.


Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. XV. Reverse electron transfer in the flavin-cytochrome beta region of the respiratory chain of beef heart submitochondrial particles.


A requirement for phospholipids by the microsomal reduced diphosphopyridine nucleotide-cytochrome c reductase.


A new phosphodiesterase forming nucleoside 5'-monophosphate from rat liver. Its partial purification and substrate specificity for nicotinamide adenine dinucleotide and oligonucleotides.


Isolation and properties of a phosphodiesterase from newborn mouse skin.


Experimental studies of intracranial arterial spasm using aortic strip assays.


Alcohol dehydrogenase of Drosophila: interconversion of isoenzymes. Isoenzymes of alcohol dehydrogenase extracted from Drosophila melanogaster are interconvertible and can be distinguished by electrophoretic mobility. When adsorbed on diethylaminoethyl cellulose, the faster-moving forms are converted to the slowest-moving form; the latter is converted to the former in the presence of 0.05 molar nicotinamide-adenine dinucleotide, and the conversion is accompanied by the binding of 3.5 moles of the dinucleotide per mole of enzyme. A change in heat stability accompanies the conversion of the slowest form of alcohol dehydrogenase to the fastest form; the latter becomes stable at 45 degrees C. The increased heat stability may indicate that a conformational change in the alcohol dehydrogenase occurs along with the binding of nicotinamide-adenine dinucleotide.


Titration patterns of a murine sarcoma-leukemia virus complex: evidence for existence of competent sarcoma virions. Stocks of inurine sarcoma virus show titration patterns ranging from one-to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that does not need coinfectinig murine leukemia virus to be manifested as a focus-forming unit. The behavior of such nondefective particles is compatible with a postulated leukemia-sarcoma virus hybrid.


Neural communications: experiment and theory.


Radiological notes: case no. 292.

Radiological notes: case no. 292.


Electron microscopy of human choriocarcinoma transplanted into hamster liver.


Ultrastructure of trophoblast and endometrium in inasive hydatidiform mole (chorioadenoma destruens).


Back and hip pain in pregnancy due to chordoma.


A colorimetric method for determination of glycols.


Study of the lungs of fetal and newborn rabbits. Morphologic, biochemical, and surface physical development.


Pathogenesis of acute gastric stress ulcers.


Endocrinology in chronic schizophrenia.

Endocrinology in chronic schizophrenia.


Tactical radiation dosimetry in the U.S. Army.


The charge distribution on the human femur due to load.


The sequelae of Japanese encephalitis in Taiwan.


Kidney injuries in children.

Kidney injuries in children.


Polycystic nephroblastoma.

Polycystic nephroblastoma.


The concentration of Polyoma virus by ammonium sulfate precipitation and purification by density gradient centrifugation.


Sir John Carew Eccles.

Sir John Carew Eccles.


Pathogenicity studies of type I-2 porcine Enterovirus.


Immunization experiments on calves with type 4 bovine adenovirus.


A pharmacological analysis of ganglionic actions of some general anesthetics.


Alterations in tissue and serum ceruloplasmin concentration associated with inflammation.


An electron spin resonance signal in brain microsomes.


The sub-mitochondrial localization of monoamine oxidase in rat liver and brain.


A rapidly labelled RNA associated with DNA in HeLa cells.


Polynucleotidases in animal tissues.

Polynucleotidases in animal tissues.


Stable carbonium ions. LX. Protonated alpha,beta-unsaturated carboxylic acids and their cleavage to alkenyloxocarbonium ions.


Substitution of egg yolk for serum in indirect fluorescence assay for Rous sarcoma virus antibody.


Variation in adrenal cortical hormones within physiologic ranges, stress and interferon production in mice.


Inhibition of erythropoietic effects of hormones by erythropoietin antisera in mildly plethoric mice.


Survival of foot-and-mouth disease virus in bovine hides.


Reactions of sheep to cell-culture-modified foot-and-mouth disease virus.


Cytomegalic inclusion disease in sand rats (Psammomys obesus): histopathologic evidence.


On the inhibition of transmission to the dorsal spinocerebellar tract by stretch of various ankle muscles of the cat.


The effect of DOPA on the spinal cord. 6. Half-centre organization of interneurones transmitting effects from the flexor reflex afferents.


Foot-and-mouth disease in man.

Foot-and-mouth disease in man.


Effect of some proteins on the yeast cell membrane. Yeast cells, Candida utilis, in water suspension and in the absence of electrolytes were found to be very sensitive to several proteins of moderate size, including ribonuclease, protamine, lysozyme, bovine serum albumin, cytochrome c, and myoglobin. Viability ceases rapidly, and ultraviolet-absorbing compounds (260 mmu) and the amino acid pool are released into the medium. The ultraviolet-absorbing material appears to be the nucleotide and coenzyme fraction usually extracted by 0.2 n perchloric acid at low temperature. The ribonucleic acid fraction remains in the cell ghosts and can be released by ribonuclease. The enzymatic properties of some of these proteins have no relation to their damaging effect on the cell membrane. Poly-l-lysine shows the same activity.


Lactic dehydrogenase activity in preimplantation rat embryo.


Ion movements in junctional transmission.


Relationship among nursing frequency, lactation pituitary prolactin, and adrenocorticotropic hormone content in rats.


Effect of thymectomy on rous virus tumor growth induced in chickens.


Studies on the mechanism of action of polymyxin B on Cholera vibrios.


Viruses recovered from laboratory dogs with respiratory disease.


ACTH-induced renal glomerular disease in intact, adrenalectomized and castrated male mice.


Some chemical and physical characteristics of purified beta-inhibitor from bovine serum.


Anterior pituitary levels of FSH, LH, ACTH and prolactin after mating in female rabbits.


Autoregulation of glucose metabolism in the isolated perfused rat liver.


Comparative susceptibility of neonatal rabbit skin to herpes simplex virus in vitro.


Virus infections of the newborn.

Virus infections of the newborn.


Analysis of estrogen metabolites by isotope derivative and by fluorimetry.


Studies on the possible viral etiology of human breast cancer.


Circumoval antibodies. Measurement during treatment of experimental schistosomiasis.


Mefenamic acid in rheumatoid arthritis.

Mefenamic acid in rheumatoid arthritis.


Studies on the mode of action of isoniazid on mycobacteria.


Studies on succinate dehydrogenase. 3. Electron-spin resonance measurements at liquid-nitrogen temperature.


Electron spin resonance study of irradiated bone and its constituents.


Wurster's blue mediated oxidation of NADH and phosphorylation in mitochondria.


The enzymatic reduction of ferrihemoglobin. II. Purification of a ferrihemoglobin reductase from human erythrocytes.


Studies on mechanism of inactivation of catechol 1,2-oxygenase by electron spin resonance.


The patient, the prescription, the problem: corticosteroid therapy in otorhinolaryngology.


Studies on rat liver ribonucleases. I. Intracellular localization of the alkal ineribonucleases.


Hepatic glycolytic and gluconeogenic enzymes of the obese-hyperglycemic mouse.


Nucleoside 5'-O-phosphorothioates as inhibitors for phosphatases.


Blood clearance of the BAI strain A virus of avian myeloblastosis in newly hatched chicks.


Use of immunofluorescence for detection of specific membrane antigen in simian virus 40-infected nontransformed cells.


Comparative morphologic study of the virus-induced solid tumors of Syrian hamsters.


Carcinogenic effects of diethylnitrosamine in RF mice.


Electron microscopic identification of viral particles in calcifying epithelioma induced by polyoma virus.


Congenital epulis in the newborn: report of 2 cases.


Variation in Bordetella pertussis.

Variation in Bordetella pertussis.


Pilot-plant experiences in demineralization of secondary effluent using electrodialysis.


Control of biochemical expression in morphologically related cells in vivo and in vitro.


Oncogenesis in vitro.

Oncogenesis in vitro.


Histochemical approaches to cell characterization in vitro.


"Spontaneous" neoplastic transformation of cells in vitro: some facts and theories.


Action of chlorpromazine on non-specific phosphatase bound to membranes in brain tissue of the rat.


Function of redox systems in melanophore receptors.


Electron paramagnetic resonance in frozen and dried biological materials.


Virus-like particles in a human primary hepatocarcinoma.


Improved multi-enzyme analyser.

Improved multi-enzyme analyser.


Phosphate esters of human erythrocytes: synthesis of ITP-14C from inosine-8-14C.


Free-radical distributions in several gamma-irradiated dry proteins as determined by the free-radical interceptor technique.


Effect of oxygen on radiation-induced free radicals in proteins.


Specific inhibition of viral ribonucleic acid replication by Gliotoxin. Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.


Parathyroid hormone production in vitro by human parathyroid cells transformed by Simian virus 40. Cells froma human parathyroid adenoma were infected with simian virus 40 and maintained through 13 subcultures in monolayer tissue culture. For more than 9 months, these "transformed" cells contimed to produce parathyroid hormone which was identified by radioimmunoassay and density-gradient ultra centrifugation.


Acute necrotizing colitis.

Acute necrotizing colitis.


Insulin-secreting islet-cell tumours of the pancreas.


Recent applications of electron spin resonance in biochemistry.


Synthesis of [5-isoleucine, 8-alanine]-angiotensin II by the solution method synthesis and the solid-phase method synthesis.


Photochemistry of biological molecules. I. Photolysis of amino acids in the solid state.


The syntheses and biological activities of [gly-11, 12,13]-alpha-ACTH(1-9)-nonadecapeptide, [gly-12,13] -alpha-ACTH-(1-17)-heptadecapeptide amide, [gly-11,13]-alphaACTH-(1-17)-heptadecapeptide amide, and [gly-13]-alpha-ACTH-(1-17)-heptadecapeptide amide.


Changes in the properties of human erythrocyte membrane protein after solubilization by butanol extraction.


Changes in EPR spectra of M-type abnormal haemoglobins induced by deoxygenation and their implications for the haem-haem interaction.


Diseases caused by cytomegaloviruses.

Diseases caused by cytomegaloviruses.


Renin-angiotensin-aldosterone system during chronic thiazide therapy of benign hypertension.


The effect of ACTH and cortisone on the behaviour of mucopolysaccharides in the glands of the rat stomach.


Clinical notes on new methods in the treatment of renal tumors.


Retroperitoneal teratoma with nephroblastic tissue as the main component.


Incorporation of 32P from [gamma-32P] ATP into polyphosphoinositides and phosphatidic acid in subcellular particles of guinea pig brain.


Electrocardiographic moniteering of patients of shock on angiotensin and noradrenaline therapy.


Studies on cytochrome a. 18. The state of existence of copper in cytochrome a and its contribution to the oxidase activity.


Uroterpenol beta-D-glucuronide.

Uroterpenol beta-D-glucuronide.


Clinical aspect of trophoblastic growth and postoperative follow-up of hydatidiform mole using basal body temperature measurement.


Influence of angiotensin on the effects of tyramine upon the contractile-force of isolated rabbit atria.


Drug effects on cardiac myosin adenosine triphosphatase activity.


Calcification of superficial nerves in leprosy.


Nerve abscess in lepromatous leprosy--report of a patient.


Encephalitis caused by herpes-simplex virus.


Herpesvirus infections of the human central nervous system.


Stretching and yawning movements after intracerebral injection of ACTH.


Modifications by catecholamines of pressor responses to angiotensin in pithed rats.


Factors influencing the measurement of conduction velocity in the human peripheral nerve.


A thecoma of ovary causing precocious puberty in a baby aged 6 months.


Skeletal development in gonadal dysgenesis, female in phenotype.


The role of radiotherapy in the management of malignant tumors of the salivary glands.


Renin-angiotensin system in microembolic renal hypertension.


A super parasite.

A super parasite.


Tobacco carcinogenesis. IX. Effect of cigarette smoke on respiratory tract of mice after passive inhalation.


An electron microscopic study of pulmonary tumor emboli from transplantable Morris hepatoma 5123.


A search for urinary 4',10-dimethyl-1,2-benzanthracene and other hydrocarbons.


Association of embryonic antigens with experimentally induced hepatic lesions in the rat.


Some properties of beta-glucuronidase activity in normal rat liver and in several transplantable rat hepatomas.


Establishment of transplantable hepatomas induced by 3'-methyl-4-dimethylaminoazobenzene with special reference to the histologic features of the transplants of early passages.


Effect of heterologous antilymphoid-cell serum on tumor isografts and viral leukemogenesis.


Clinical evaluation of 5-bromo-5-fluoro-6-methoxy-dihydro-2'-deoxyuridine.


Cytochemical studies on the mouse mammary tumor virus.


Comparative studies of the nucleoli of Morris hepatomas, embryonic liver, and aflatoxin B1-treated liver of rats.


Screening data from the cancer chemotherapy National Service Center Screening Laboratories. XLV.


Incorporation of 14-C-labeled acetate into lipid by isolated foam cells and by atherosclerotic arterial intima.


Enhancement of peripheral alpha-receptor stimulation by blockade of "silent" beta receptors.


Sequential solvent extraction of urinary corticosteroids and its clinical application.


Embryogenesis in Hymenolepis diminuta. IV. Distribution of succinic dehydrogenase, reduced form of nicotinamide-adenine dinucleotide oxido-reductase, and cytochrome oxidase.


Lipids from Entamoeba histolytica.

Lipids from Entamoeba histolytica.


Carcinomatous neuromyopathy. The nonmetastatic neurological complications of cancer.


Effect of melatonin and 5-hydroxytryptamine on aldosterone and corticosterone production by adrenal glands of normal and hypophysectomized rats.


Gel filtration of oestrogen conjugates in bovine urine.


A rapid method for extracting corticotrophin from plasma.


Model reactions for the biosynthesis of thyroxine. XI. The nature of a free radical formed in the autoxidation of 4-hydroxy-3,5-diiodophenylpyruvic acid.


Anogenital cutaneous lesions.

Anogenital cutaneous lesions.


Viral neoplastic transformation of hamster prostate tissue in vitro. Cultures of hamster prostatic tissues infected with simian virus 40 undergo transformation in vitro, and the transformed cells produce malignant tumors when injected into homologous hosts. Tartrate-inhibited acid phosphastase is found in the cultures of transformed cells and in the tumors they produce. Tartrate-inhibited acid phosphatase activity is elevated in the serum of tumor-bearing animals.


Adrenal cortex in marasmic children.

Adrenal cortex in marasmic children.


Lymphocyte and granulocyte enzyme activity in patients with Down's syndrome.


Relationship of histologic features to behavior of cystosarcoma phyllodes. Analysis of ninety-four cases.


Herpes-type virus infection in adult with hematologic disorder. Electron microscopic observations of virus and case report.


Cancer mortality among patients in New York mental hospitals.


Wilms' tumour-a review of 45 consecutive cases.


Metabolism of vitamin D3-3H in vitamin D-resistant rickets and familial hypophosphatemia. The fate of an intravenous dose of tritiated vitamin D(3) was studied in seven normal subjects, four children with vitamin D-resistant rickets, and four adults with a familial history of vitamin D-resistant rickets and persistent hypophosphatemia. An abnormal metabolism of vitamin D in vitamin D-resistant rickets was defined and characterized by a decrease in the plasma fractional turnover rate, a marked increase in plasma water-soluble metabolites, and a relative decrease in the conversion of vitamin D to a polar, biologically active metabolite. Alterations in vitamin D metabolism in the adults with persistent hypophosphatemia were similar but less severe than those of affected children with vitamin D-resistant rickets. It is tentatively concluded that the abnormalities in vitamin D metabolism documented in patients with vitamin D-resistant rickets and familial hypophosphatemia may account for the observed osseous and biochemical changes.


A study of mechanisms by which adrenocorticotropic hormone maintains adrenal steroidogenic responsiveness. Following hypophysectomy in the rat, there was a progressive decline in the rate of adrenal protein synthesis in vivo during the ensuing 24-48 hr, and an accompanying decrease in the acute corticosterone secretory response to an intravenous injection of ACTH. There was a similar decrease in the in vitro conversion of Delta(5)-pregnenolone, progesterone, and deoxycorticosterone to corticosterone. These in vivo and in vitro effects of hypophysectomy could be reversed by the administration of depot ACTH for an additional 7 hr period. However, if cycloheximide, an inhibitor of protein synthesis, was administered concomitantly with the depot ACTH, then the restorative actions of ACTH on the steroid biosynthetic pathway were prevented. These experiments suggest that ACTH maintains not only the general structure of the adrenal cortex, but also the level of the steroid biosynthetic mechanism, through its effects on adrenal protein synthesis.


A study on the virus aetiology of mild respiratory infections in the primary school child.


Hypophosphatasia: clinical and metabolic studies.


The role of sodium-potassium-activated adenosine triphosphatase in the reabsorption of sodium by the kidney. In order to evaluate the possible role of sodium- and potassium-activated adenosine triphosphatase in the active transport of sodium by the renal tubules, we examined the effect of large changes in the tubular reabsorptive load of sodium on the Na-K-ATPase activity of rat kidney homogenates. Glomerular filtration and tubular reabsorption of sodium per gram of kidney tissue increased progressively after contralateral uninephrectomy. This was paralleled by an increase in Na-K-ATPase per milligram of protein in a microsomal fraction of kidney cortex. The importance of this change is underlined by the absence of simultaneous increases in other microsomal enzymes such as glucose-6-phosphatase and Mg(++)-dependent ATPase, or in succinic dehydrogenase or glutaminase. Similar increases in Na-K-ATPase were observed when the net tubular reabsorption of sodium was increased by feeding the animals a high-protein diet or after injection of methylprednisolone. On the other hand, Na-K-ATPase was lowered when tubular transport of sodium was reduced by bilateral adrenalectomy. The results of these experiments show that renal Na-K-ATPase changes in an adaptive way when renal reabsorption of sodium is chronically increased or diminished and support the hypothesis that this enzyme system is involved in the process by which sodium is actively transported across the renal tubule.


Familial holoprosencephaly with endocrine dysgenesis.


Cartilage and cartilage grafts: the basic properties of the tissue and the components responsible for them.


Experiments with 8 nerve section and the cochleo-cochlear mechanisms.


Intramedullary tumours of the spinal cord.


Histological and histochemical studies on cholesteatoma epidermis.


Ultrastructure of the glomus jugulare tumor.


Head colds and viral cochleitis.

Head colds and viral cochleitis.


Membrane lipid changes during formation of a functional electron transport system in Staphylococcus aureus. Addition of oxygen to a culture of anaerobically growing Staphylococcus aureus results in the formation of a membrane-bound, functional electron transport system. With the shift to aerobic growth, there is at least a 15-fold increase in cytochrome a and at least a 55-fold increase in cytochrome oxidase o. At the completion of the shift to aerobic growth, the cytochrome levels equal those found in bacteria grown with aeration throughout the entire growth cycle. Cytochromes b(1) and o are formed first. Their synthesis slows when cytochrome a becomes detectable. Concentrations of cytochromes b(1) and sometimes cytochrome a increase late in the adaptive period. Concomitant with this is a decrease in the oxygen tension at which the rate of oxygen utilization becomes dependent on the oxygen concentration. During the shift to aerobic growth, the protoheme content increases ninefold, and all the protoheme can be accounted for in enzymatically reducible cytochrome b(1) and cytochrome oxidase o. Protoheme, but not a functional cytochrome system, is synthesized by anaerobically growing S. aureus. Heme a appears only after a period of aerobic growth. During the shift to aerobic growth, there is a 1.6-fold increase in the vitamin K(2) content, with an alteration in the ratios of the 35 and 45 carbon side chain isoprenologues. A twofold increase in phosphatidyl glycerol and a 1.6-fold increase in cardiolipin occur with the shift to aerobic growth. Lysyl-phosphtidyl glycerol remains essentially constant in this period. Concentrations of mono- and diglucosyl diglycerides increase coordinately 1.3-fold during the shift to aerobic growth at a 2.5 to 1 m ratio.


O-methylthreonine inhibition of growth and of threonine deaminase in Escherichia coli. O-methylthreonine (OMT), an isosteric analogue of isoleucine, markedly inhibited growth of Escherichia coli 15. This inhibition was overcome most effectively by addition of isoleucine, valine, or leucine to the medium and less effectively by addition of threonine. The dipeptide, valylleucine, also relieved the OMT-induced inhibition but only after a lag period, suggesting that valine and leucine, liberated by dipeptidase action, compete with OMT for entry into the cell. OMT was activated and transferred to transfer ribonucleic acid (RNA) by isoleucyl-RNA synthetase in vitro. The rate of OMT incorporation into protein of intact cells was comparable to that of isoleucine. In contrast to isoleucine, very high concentrations of OMT were required to inhibit threonine deaminase, and the inhibition was strictly competitive with threonine. In addition, OMT inhibited a threonine deaminase preparation desensitized to isoleucine inhibition.


Angiotensin-aldosterone interrelationship in liver cirrhosis.


Numerical data concerning the sensitivity of anaerobic bacteria to oxygen. Upon comparison of results obtained from growing eight different species of anaerobic bacteria in deep agar under two and three atm of pure oxygen with results of growing them in air under atomospheric pressure, it appears possible that the old terms of "microaerophobic," "very strict anaerobe," and "microaerophilic" can be replaced by precise values corresponding to the size of the inhibition zone produced by oxygen under various pressures when the bacteria are grown in a solid medium. The simultaneous effect of the dilution of the inoculum and the pressure of oxygen used was determined with the help of an electronic computer according to the standard multiple regression method. Two indices have been worked out which express the sensitivity of the species at different oxygen pressures when varying numbers of anaerobic bacteria are used: X sp, which is the size in millimeters of the inhibition zone when 1:10 dilutions of the culture are grown under pure oxygen at atmospheric pressure (lp=0), and B sp, which is the result of multiplying by 1.43 the difference in size of inhibition zone when 1:10 dilutions of the culture are grown under atmospheric air (lp = -0.7) and under pure oxygen at 1 atm absolute.


Light and electron microscopy of adrenocorticotrophin-induced renal glomerular disease in mice.


Release of surface enzymes in Enterobacteriaceae by osmotic shock. The process of osmotic shock, which has been used to release degradative enzymes from Escherichia coli, can be applied successfully to other members of the Enterobacteriaceae. Cyclic phosphodiesterase (3'-nucleotidase), 5'-nucleotidase (diphosphate sugar hydrolase), acid hexose phosphatase, and acid phenyl phosphatase are released from Shigella, Enterobacter, Citrobacter, and Serratia strains. Some strains of Salmonella also release these enzymes. Members of Proteus and Providencia groups fail to release enzymes when subjected to osmotic shock and do not show a lag in regrowth, although they do release their acid-soluble nucleotide pools. In contrast to E. coli, release of enzymes from other members of the Enterobacteriaceae studied is affected by growth conditions and strain of organism. None of the organisms was as stable to osmotic shock in exponential phase of growth as was E. coli. Exponential-phase cells of Shigella, Enterobacter, and Citrobacter could be shocked only with 0.5 mm MgCl(2) to prevent irreparable damage to the cells. These observations suggest that this group of degradative enzymes is probably loosely bound to the cytoplasmic membrane through the mediation of divalent cations.


The introduction of hydrocyanic acid into medicine. A study in the history of clinical pharmacology.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-1968.


Irradiation of dihydropyrimidines.

Irradiation of dihydropyrimidines.


Rapid labeling of RNA in Saccharomyces cerevisiae during gamma irradiation correlated with catalase formation.


Treatment of aplastic anemia in children.


Pharmacologic and endocrine aspects of carcinoid syndrome.


Sarcoma of the breast.

Sarcoma of the breast.


Reticulum cell sarcoma: demonstration of chromosomal changes analogous to those in SV40-transformed cells.


Cancer hazard from mineral oil used in the processing of jute.


Effect of age, sex, and hormonal state on tritiated thymidine uptake by rat pituitary.


Development of adrenal cortical carcinoma in C3H mice following castration and the administration of 7,12-dimethylbenz(a)anthracene.


Demonstration of tumour-specific humoral antibody against aminoazo dye-induced rat hepatomata.


An unusual breast tumour in an adolescent girl.


Viruses of the alimentary tract of chimpanzees.


A structural analysis of hepatomegaly induced by a hormone-secreting tumor.


Steroid conjugates. 3. The synthesis of sulfoglucuronide derivative of estriol.


A study on natural infection of simian virus 40 (SV40) in Taiwan monkeys (Macaca cyclopis).


Biochemistry of the development of duck embryo. 1. Some enzymes of carbohydrate metabolism in the developing liver.


Disseminated herpes simplex virus infection.


Intrathoracic chemodectoma.

Intrathoracic chemodectoma.


Macroradiography in 4 times magnification applied to cerebral angiography.


Conversion of angiotensin I to angiotensin II.


Virus-like particles in blood lymphocytes in acute Marek's disease.


Lack of resistance of adult mice to erythrocyte-borne Bittner virus.


Electron spin resonance investigation of conformation changes in serum albumin with the help of iminoxyl paramagnetic label.


Transmission in invertebrate and vertebrate ganglia.


Definitive diagnosis of insulin-secreting tumors of the pancreas.


Further studies on the production of interferon by human leukocyte in vitro.


Mitochondrial functions of polymelanosomes.


Effect of hypophysectomy on the fatty acids and lipid classes of rat testes.


The oxidase systems of Moniezia expansa (Cestoda).


Effect of insulin on the synthesis of glycogen in cerebral cortical slices of alloxan diabetic rats.


Pharmacologic effects of angiotensin-II-amide on aldosterone and corticosterone secretion by the intact anesthetized rat.


Islet cell adenoma of pancreas. A case report and brief review of literature.


The effect of long-term corticotrophin treatment on the corticosteroid-binding capacity of transcortin.


The influence of hypophysectomy, corticotrophin and cortisol on the adrenal medulla of the rat.


Photodynamically inactivated vaccines prepared by growing viruses in cells containing neutral red.


Induction of interference and interferon synthesis by non-replicating molluscum contagiosum virus.


Prevention of SV40 virus oncogenesis in hamsters. II. The effect of thymectomy on induction of tumor resistance by SV40-transformed human cells.


Microslide acrylamide gel electrophoresis technique for tissue lactic dehydrogenase.


An immunofluorescent method for Yaba virus assay.


Changes in Simian Virus 40 susceptibility and chromosome numbers during long-term cultivation of BS-C-1 cells.


Regulation of cytochrome oxidase in human cells in culture.


Influence of the injection of "Triton WR-1339" on lysosomes of a rat transplantable hepatoma.


The effects of ionizing radiation on nucleic acids of bacteriophages and bacterial cells.


Effect of angiotensin on uptake and release of norepinephrine by brain.


Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.


Subcellular localization of ethylenediaminetetraacetate in the proximal tubular cell of the rat kidney.


Stress and the maintenance of nicotinamide-induced hepatic nicotinamide adenine dinucleotide elevation by chlorpromazine.


The control of glycolysis in early embryogenesis.


Major metabolic pathways of glucose in normal human lymphocytes and the effect of cortisol.


Nitroxide mixed carboxylic-carbonic acid anhydrides. A new class of versatile spin labels.


Evidence of reduction of fumarate to succinate in perfused rat liver under conditions of reduced O2 tension.


Titration of tuberculin, nucleic acids and viruses by haemaggregation inhibition using a "pattern" test.


Human embryo kidney fibroblasts for the isolation and growth of rhinoviruses.


Aldosterone production and juxtaglomerular granules.


A study of the production, source and action of interferon appearing in mice after the intravenous injection of influenza virus.


Breast carcinoma. A histological and prognostic study of 650 followed-up cases.


Endemic goitre in eastern New Guinea, with special reference to the use of iodized oil in prophylaxis and treatment. Previous surveys have indicated a high goiter endemicity in the mountainous Huon peninsula of eastern New Guinea, a study was carried out in 1964 which indicated severe iodine deficiency in the inhabitants of the area.  Trials were undertaken to determine whether the injection of iodized oil would correct that deficiency and what effect injections given in previous years had had.  The results showed that, whereas the urinary iodine and 131 I uptake in New Guineans who had received iodized oil in 1957 were similar to those in untreated persons, yet a single 4 ml injection (2.15 g iodine) of iodized oil appeared substantially to correct iodine deficiency for 4-5 years.  There was also a significant regression of goiter in 60 of 61 persons with easily visible goiters within 3 months of their receiving an injection.  No case of thyrotoxicosis or iodism was seen in more than 2000 persons who were given injections.  The authors recommend the injection of iodized oil particularly for the correction of iodine deficiency in children and in women of childbearing age whenever the efficacy of other measures is uncertain.  The  method is relatively inexpensive and well-suited to mass prophylaxis among people with a low standard of living.  (author's)


Auscultatory sign in primary carcinoma of the liver.


Ultrastructure of methylcholanthrene-induced fibrosarcomas in the Swiss albino mouse.


A difference in mechanism by which leucine and other amino acids induce insulin release.


Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA). The acquisition of the defective SV40 genome by a variety of human adenovirus serotypes by the process of transcapsidation has resulted in the addition of oncogenic potential for newborn hamsters to the previously nononcogenic adenovirus types 1, 2, 5, and 6. These serotypes have previously been grouped together by the high GC content of their DNA. Transcapsidation of the SV40 genome to weakly oncogenic adenovirus types 3, 14, 16, and 21 has failed to increase their oncogenic potential although the parent adenovirus type 7 carrying PARA is highly oncogenic. These serotypes belong to the group possessing a DNA of intermediate GC content. All the PARA-adenovirus populations, even those that were nononcogenic, were able to induce SV40 transplantation immunity and therefore carry the SV40 transplantation marker as well as the marker for synthesis of SV40 tumor or T antigen.


Radiologic seminar LXVII: bronchial adenoma.


Adeno-associated satellite virus interference with the replication of its helper adenovirus. Adeno-associated satellite virus type 4 interferes with the replication of its helper adenovirus. No interferon-like soluble substance could be detected in satellite-infected cultures and other DNA- and RNA-containing viruses were not inhibited by coinfection with satellite virus under conditions which reduced adenovirus yields by more than 90% in monkey cells. Altering the concentration of adenovirus in the presence of constant amounts of satellite resulted in a constant degree of interference over a wide range of adenovirus inocula and suggested that adenovirus concentration was not a significant factor in the observed interference. The interference with adenovirus replication was abolished by pretreating satellite preparations with specific antiserum, ultraviolet light or heating at 80 degrees C for 30 min. This suggested that infectious satellite virus mediated the interference. Satellite virus concentration was found to be a determinant of interference and studies indicated that the amount of interference with adenovirus was directly proportional to the concentration of satellite virus. 8 hr after adenovirus infection, the replication of adenovirus was no longer sensitive to satellite interference. This was true even though the satellite virus was enhanced as effectively as if the cells were infected simultaneously with both viruses. Interference with adenovirus infectivity was accompanied by reduced yields of complement-fixing antigen and of virus particles which suggested that satellite virus interfered with the formation and not the function of adenovirus products. When cells were infected either with adenovirus alone or with adenovirus plus satellite, the same proportion of cells plated as adenovirus infectious centers. However, the number of plaque-forming units of adenovirus formed per cell in the satellite-infected cultures was reduced by approximately 90%, the same magnitude of reduction noted in whole cultures coinfected with satellite and adenovirus. This suggested that all cells infected with the two viruses were producing a reduced quantity of adenovirus.


Cylindromas of the head and neck.

Cylindromas of the head and neck.


Vincristine neurotoxicity in rodents.

Vincristine neurotoxicity in rodents.


Studies on rous sarcoma virus in mice. II. Clonal analysis of cell populations of the SR-RSV-induced mouse ascites sarcoma (SR-C3H/HE ascites).


Propagation and cytopathic effects of Japanese encephalitis and related viruses in mammalian cerebellar tissue cultures.


Studies on glycogen contents of cerebral cortex in hyperthermia, hypothermia and administration of several drugs.


Electrophoretic mobility and biological behaviors of rat ascites hepatoma cells.


Respiratory distress and convulsions in newborn.


A fatal case of dengue hemorrhagic fever in an American child.


Wilms' tumor and congenital hemihypertrophy: report of five new cases and review of literature.


Immunogenicity of bovine rhinotracheitis--virus diarrhea vaccine in cattle inoculated simultaneously with concentrated homologous antiserum.


Initial, presumptive therapy for serious acute gram-negative rod infections: preliminary report of a controlled clinical trial.


Blood glucose level in mice. 3. On the nature of corticotrophin-induced hypoglycaemia.


Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus.


Disseminated herpes simplex virus infection. Its pathogenesis based on virological and pathological studies in 33 cases.


Effect of beta irradiation on ganglionic bioelectric activity.


Effect of lactation and perchlorate on thiocyanate metabolism.


Metabolic effects of angiotensin.

Metabolic effects of angiotensin.


Autoregulation of renal blood flow in the presence of angiotensin infusion.


Regional differences in vascular tachyphylaxis to angiotensin in the cat.


Association of zoster and malignant disorders in children.


Two complications of trigeminal injury occurring in one patient.


Studies on the development of a radioimmunoassay for angiotensin II.


A fundamental defect of adrenocortical control in Cushing's disease.


Steroid secretion by the adrenal gland of foetal and neonatal sheep.


Double isotope assay of aldosterone, corticosterone and cortisol in human peripheral plasma.


Tetrodotoxin's highly selective blockage of an ionic channel.


Ultrastructural studies of experimental vesiculation. II. Collagenase.


Studies of ultrastructural changes in liver cells. I. Electron microscopic observations on human and rat liver in hyperthyroidism.


A simple and sensitive procedure for the microdtermination of nitrogen in biological materials.


Thin-layer chromatography.

Thin-layer chromatography.


Site of attachment of retinal in rhodopsin.


Effect of humming on vision.

Effect of humming on vision.


Amino-acid sequence of glyceraldehyde 3-phosphate dehydrogenase from lobster muscle.


Determination of free radicals in gamma irradiated proteins.


Inhibition of multiplication of foot and mouth disease virus in adult mice pretreated with Freund's complete adjuvant.


Myasthenia gravis treated with ACTH.

Myasthenia gravis treated with ACTH.


Interferon: production by chick erythrocytes activated by cell fusion. In the presence of Sendai virus inactivated with ultraviolet light, nucleated chick erythrocytes can be fused with several types of human cells to form heterokaryons. Although chick erythrocytes alone cannot be stimulated by Sendai virus to produce interferon, fusion with a human cell (AH-1) which itself may produce human interferon results in heterokaryons in which the erythrocyte genome is activated and chick interferon is produced. When nucleated chick erythrocytes are fused with another type of human cell (HeLa clone S-3) which does not produce human interferon when stimulated, no chick interferon is detectable, despite morphologic changes suggestive of activation of the erythrocyte nuclei.


Effect of high-power ruby laser irradiation on peripheral nerve.


The effect of 5-bromo-2-deoxyuridine on the multiplication of equine herpes 3 virus in rabbit kidney cells.


Kinetic studies of temperature changes and oxygen uptake in a differential calorimeter: the heat of oxidation of NADH and succinate.


Induction of the division cycle in resting stage human fibroblasts after RSV infection.


Mössbauer effect in peroxidase.

Mössbauer effect in peroxidase.


Persistance of the effects of regulatory reagents on conformation of catalytically inactive glutamate dehydrogenase.


Some aspects of the hydrolysis of phosphomonoesters by homogenates of growing and regressing mesonephroi in chick embryos.


Mast cells in nerves affected with fowl paralysis (Marek's disease).


Method for obtaining several microcultures in the same petri dish.


The value of extended incubation and subcultures in the isolation of Entamoeba histolytica from stool specimens.


Silica excretion in cattle fed a ration predisposing to silica urolithiasis: total excretion and diurnal variations.


Experimental infection of calves with myxovirus parainfluenza-3 and Pasteurella haemolytica.


Application of stresses to foot-and-mouth disease virus.


Application of the agar gel technique in the diagnosis of infectious bovine rhinotracheitis.


Adrenergic neurone blocking activity of some new guanidine derivatives.


Influence of new guanidine derivatives on ganglionic and neuromuscular transmission.


Some effects of morphine on pituitary-adrenocortical function in the rat.


Comparison of the effects of disulfiram and dimercaptopropanol arsenite on mitochondrial structure and function.


A phosphodiesterase from the carrot.

A phosphodiesterase from the carrot.


A new assay for adenosine 3',5'-cyclic monophosphate in tissue.


The properties of dicyclohexylcarbodiimide as an inhibitor of oxidative phosphorylation.


Aftercare for former day hospital patients.


Fatty acid components of lipid fractions of Yoshida sarcoma and rat ascites hepatomas.


Serological reactions in sheep-pox. II. Agar-gel diffusion test.


Effects of hormones on the renal response to unilateral nephrectomy in hypophysectomized rats.


An unusual course of experimental mouse virus leukaemia.


Changes in the cultures of chicken bone marrow cells infected with the virus of chicken myelocytomatosis (strains Mc-29 and Mc-31).


Susceptibility of turkey-poults to avian leukosis strains Mc-29 and Mc-31 and pathomorphological spectrum of neoplastic growths.


The adrenal cortical glucocorticoid function in asthmatic children.


Experimental striatal necrosis induced by sodium azide. A contribution to the problem of selective vulnerability and histochemical studies of enzymatic activity.


Regulation of liver microsomal inorganic pyrophosphate-glucose phosphotransferase, glucose-6-phosphatase and inorganic pyrophosphatase.


Lactate dehydrogenase activity in the preimplantation rabbit embryo.


The effects of multiple and single administration of dimethylnitrosamine to hamsters.


Isolation of smallpox virus in monkey kidney tissue culture.


Urothelial implantation of Wilms' tumors.


Mechanism of the bactericidal action produced by electrohydraulic shock. Electrohydraulic shock was shown to produce oxidation reactions which inactivated certain compounds important in cellular metabolism. Enzymes that were inactivated included lactic dehydrogenase, trypsin, and proteinases of Bacillus subtilis. Free sulfhydryl groups and reduced nicotinamide adenine dinucleotide were oxidized. Adenosine triphosphate was destroyed, but deoxyribonucleic acid was not affected. Intracellular material of Escherichia coli lost its ability to absorb at 260 mmu after electrohydraulic shock. The bactericidal mechanism involved appeared to be due to nonselective oxidation reactions produced by high-voltage discharges in water. These oxidation reactions were probably mediated by free radicals produced in the water.


Effect of cookery and holding on hams and turkey rolls contaminated with Clostridium perfringens. Canned hams, turkey rolls, and ground-beef casseroles were inoculated with a mixture of vegetative cells and spores of selected strains of Clostridium perfringens, in approximately known numbers. After cooking and holding at different temperatures for various times, samples of the food were plated directly on sulfadiazine-polymixin-sulfite-agar. In all cases, small but measurable percentages of the organisms survived cookery. The number of cells viable after cookery of the ham or turkey was influenced by the position of the slice of meat in the roast as well as by the final temperature to which the product was heated. Plate counts for turkey or beef casserole held at temperatures in the range of 5 to 10 C for 48 hr indicated stabilization of the population or a tendency to decrease. At 24 C, the multiplication of cells was apparent in 4 hr and rapid in 6 hr. When the food was maintained at 68 C, populations remained viable for 6 hr and the counts did not change markedly. In turkey maintained at 37 C, the number of cells increased sharply within 4 hr.


Prior breast disease in patients treated for papillary carcinoma.


Treatment of mengovirus infection in mice with statolon. A single intraperitoneal injection of statolon was shown to exert a therapeutic effect on mice previously injected with the large plaque-forming variant of mengovirus. The ld(50) and survival time data demonstrated that such treatment was effective when given 2 to 48 hr after infection. No protective effect was apparent when statolon was administered 3, 4, or 5 days after the viral challenge. It was concluded that statolon, or other similar interferon inducers, may be of therapeutic value in instances of accidental or other known exposure to hazardous viral agents.