Agar gel diffusion studies of paravaccinia viruses.


Isolation of parainfluenza virus from the lungs and nasal passages of sheep showing respiratory disease.


Effects of hypophysectomy and several hormone replacement therapies upon patterns of nucleic acid and protein synthesis and enzyme levels in lactating rat mammary glands.


Synthesis of the four pairs of side-chain epoxides epimeric at carbon 20 derived from 5-beta-pregnan-3-alpha-ol.


The mode of development of Japanese encephalitis virus in the mosquito Culex tritaeniorhynchus summorosus as observed by the fluorescent antibody technique.


Hemagglutination inhibition antibody titers against Japanese encephalitis virus from human and pig sera of Amami-Oshima Island.


Comparative studies on the breeding habits of a laboratory adapted variant and wild colonies of Culex tritaeniorhynchus summorosus, the principal vector of Japanese encephalitis.


Methylcholanthrene-induced sarcoma in singly fractured bone of mice.


Growth characteristics of Japanese encephalitis virus in chick embryo cells with special reference to the applicability of the culture to the production of inactivated vaccine.


Murine cytomegalovirus: observations on growth in vitro, cytopathic effect, and inhibition with 5-Iododeoxyuridine.


Rabbits' corneal cells studied in tissue cultures. II. Enzyme reactions.


The roentgenographic findings in total lipodystrophy.


Wilms' tumor.

Wilms' tumor.


Toxoplasmosis complicating malignancy. Experience at the National Cancer Institute.


Chemodectomas (nonchromaffin paragangliomas) of the head and neck. A clinicopathologic study.


Inhibition of thymidylate kinase and DNA polymerase by the periodate oxidation product of beta-D-ribosyl-6-methylthiopurine.


The utilization of trytophan and its metabolites for pyridine nucleotide synthesis in tumors and host liver.


Sequential morphologic changes in aflatoxin B carcinogenesis in the rat.


Localization of "spontaneous" and Rous sarcoma virus-induced breakage in specific regions of the chromosomes of the Chinese hamster.


Immunosuppressive and antitumor activity of periodate oxidation product of beta-D-ribosyl-6-methylthiopurine.


Acceleration of leukemogenesis in AKR mice by grafts, cell suspensions, and cell-free centrifugates of thymuses from preleukemic AKR donors.


Murine sarcoma virus (Harvey): characteristics of focus formation in mouse embryo cell cultures, and virus production by hamster tumor cells.


Studies on carcinogenesis by avian sarcoma viruses. 8. Glycolysis and cell multiplication.


Report on the workship on virus induction by cell association.


Birth order and desire for and participation in psychiatric posthospital services.


Complications of cardiac catheterization and angiography. Catheterization laboratory experience in a small hospital.


Further properties of the balanced-detector electron spin resonance spectrometer.


Practical methods of dating skeletal remains: a preliminary study.


Studies on the pancreatitis in a mouse hepatitis virus (MHV-3) infection.


Influence of chronic exercise and electrical stress on hepatic glucose-6-phosphatase activity in rats.


An uncommon indication for chlorpheniramine.


Vascular responses in mesenteric arteries from genetic and renal hypertensive rats.


Control of reduced diphosphopyridine nucleotide oscillations in beef heart extracts. I. Effects of modifiers of phosphofructokinase activity.


Control of reduced diphosphopyridine nucleotide oscillations in beef heart extracts. II. Oscillations of glycolytic intermediates and adenine nucleotides.


Control of reduced diphosphopyridine nucleotide oscillations in beef heart extracts. 3. Purification and kinetics of beef heart phosphofructokinase.


Association of alpha-S-casein C in the alkaline pH range.


Vitamin D3 induction of a calcium-binding protein in the uterus of the laying hen.


Adenine nucleotide inhibition of pea malate dehydrogenase.


Formation of delta-3-isopentenyl monophosphate and pyrophosphate in the latex of Hevea brasiliensis.


Facial paralysis and otological symptoms due to secondary carcinoma.


On metabolites of acetyldigoxin-beta in the heart muscle and blood of rats after oral administration of glycoside.


Studies of the electron transport systems of heart muscle: biochemical and antigenic properties of a soluble DPNH dehydrogenase.


The toxic proteins of cobra venom.

The toxic proteins of cobra venom.


The effects of neuromuscular blocking agents on mitochondria. IV. Effects of d-tubocurarine, pyrrolizidine alkaloids and magnesium on oxidative phosphorylation.


The metabolism of the octamethylene-1,8-dithiol moiety of bis(O-acetylthiamine)octamethylene-18,-disulfide in rat and man.


Corticotrophin in multiple sclerosis and retrobulbar neuritis.


The intracellular distribution of mercury in rat liver after a single injection of mercuric chloride.


Treatment for facial palsy.

Treatment for facial palsy.


Heat and radiation resistance and activation of spores of Clostridium welchii.


Low temperature growth characteristics of clostridia.


Studies on the pharmacology of alpha-methyl-3,4-dihydroxyphenylalanine (alpha-methyl-dopa) and alpha-methyl-norepinephrine. I.


Magnetic resonance studies on irradiated crystals of chloroacetyl DL-alanine.


Biological timing and the dento-facial complex.


Kinins, beta-adrenergic receptors and functional vasodilatation in the submaxillary gland of the cat. 1. The close arterial infusion of bradykinin into the submaxillary gland of the cat produced a pronounced hyperaemia that could be blocked by simultaneous perfusion of the gland with blood containing carboxypeptidase B. Carboxypeptidase B, however, failed to reduce the vasodilatation of chorda tympani nerve stimulation suggesting that the kinins are not involved in the regulation of submaxillary gland blood flow.2. Isoproterenol injections produced pronounced salivary gland vasodilatation. Beta-adrenergic blocking drugs reduced or abolished the hyperaemia of isoproterenol and reduced that of chorda tympani nerve stimulation. The combination of beta-blocking drugs and atropine could abolish or reduce further this nerve induced hyperaemia.3. The above results suggest that stimulation of cholinergic and beta-adrenergic receptors could account for the chorda tympani induced hyperaemia. Conclusive proof of this possibility remains to be determined.


Castor bean FDPase from endosperm tissue: properties and partial purification.


Pharmacology of pH effects on carotid body chemoreceptors in vitro. 1. The carotid body and the carotid nerve were removed from anaesthetized cats and placed in a small Perspex channel through which Locke solution (at various pH values and usually equilibrated with 50% O(2) in N(2)) was allowed to flow. The glomus was immersed in the flowing solution while the nerve was lifted into oil covering the saline. Sensory discharges were recorded from the nerve and their frequency was used as an index of receptor activity. At times, a small segment of carotid artery, containing pressoreceptor endings, was removed together with the glomus. In this case, pressoreceptor discharges were recorded from the nerve.2. The amplitude of either chemo- or pressoreceptor discharges was not changed by strong acid solutions. Acid decreased the frequency of the baroreceptor discharges only when pH fell to less than 4.0. Solutions at low pH increased the chemosensory discharge, but acid depressed the increased chemoreceptor discharge elicited by KCl. These experiments indicated that H(+) ions probably acted as membrane ;stabilizers' without depolarizing either the nerve fibres or endings.3. Acid solutions increased the action of acetylcholine chloride (AChCl) (100-200 mug) on chemoreceptors. This effect probably was due either to inactivation of tissue cholinesterase or to enhanced sensitivity of the sensory endings to ACh.4. Choline chloride (10(-3)M), which favours ACh synthesis, protected the preparation against decay during prolonged experimentation. Hemicholinium-3 (HC-3), which blocks ACh synthesis in low concentrations (10(-5)M), depressed the chemosensory response to acid and to hypoxia when such stimuli were applied repeatedly. This concentration of HC-3 did not change effects of applied ACh.5. Substances which affect ACh release markedly changed the chemoreceptor discharge increase induced by acidity and other forms of stimulation. In the absence of Ca(2+), acid, anoxia, and interruption of flow provoked receptor depression while receptor excitation induced by ACh and KCl persisted. All stimuli excited and showed increased effectiveness as the Ca(2+) concentration was raised, but their effects declined as Ca(2+) was increased above normal values. Mg(2+) ions depressed the chemoreceptor effects induced by all these stimuli. The action of Mg(2+) was not due entirely to nerve ending block. Morphine sulphate (which decreases ACh release in other structures) also depressed the receptor response to acid and flow interruption.6. Cholinergic blocking agents such as mecamylamine, hexamethonium, atropine, dihydro-beta-erithroidine (DHE), HC-3 (10(-4)M), choline and acetylcholine (in combination with choline) depressed the effects of acid and ACh on the chemoreceptors. The effect induced by interruption of flow was depressed only by mecamylamine and DHE.7. Agents which affect the fate of released ACh, such as acetylcholinesterase and eserine salicylate, did not affect clearly the response of chemoreceptors to acid.8. The results suggest that acid stimulates chemoreceptor fibres through an indirect mechanism, viz. through increased release and/or decreased destruction of a presynaptic transmitter from the glomus cell. This transmitter is probably ACh (see following paper, Eyzaguirre & Zapata, 1968).


Acetylcholine stimulation of the phosphodiesteratic cleavage of guinea pig brain phosphoinositides.


The release of acetylcholine from carotid body tissues. Further study on the effects of acetylcholine and cholinergic blocking agents on the chemosensory discharge. 1. Both carotid bodies were removed from cats and placed in a small Perspex channel through which Locke solution was allowed to flow under a layer of paraffin oil. Stimulation of the upstream (;donor') organ elicited an increased sensory discharge in the downstream (;detector') preparation (Loewi effect).2. This effect was enhanced by eserine, depressed by hexamethonium and blocked by either mecamylamine or acetylcholinesterase. The Loewi effect did not disappear when chronically denervated (4 days) ;donor' carotid bodies were stimulated.3. These experiments led to the conclusion that ACh is released by the carotid body tissues (probably from the glomus cells) during stimulation and that this substance is responsible for the initiation of the chemosensory discharges.4. In single preparations the chemosensory endings proved to be very sensitive to ACh especially in the presence of eserine which, in all probability, inactivated the tissue cholinesterase. Curarizing agents such as mecamylamine, hexamethonium, (+)-tubocurarine and atropine blocked the response of the sensory endings to applied ACh in what appeared to be ;surmountable' antagonism.


The effect of growth on the levels of acylphosphatase and some glycolytic enzymes in rat muscle.


Treatment of diseases of the ovaries affecting growth and development.


Curare and acetylcholine receptor substance.


In vitro regulation of the lipolysis of adipose tissue.


Effect of bromide ions on junctional transmission.


Mechanically induced free radicals in bone.


Single strand scissions of DNA caused by a carcinogen, 4-hydroxylaminoquinoline 1-oxide.


Validity of a method measuring transmitter release from the central nervous system.


Electron spin resonance of ferromagnetic particles in airborne dust.


Vascular reactivity in human hypertension.


Vascular reactivity in experimental hypertension.


The morphological basis for the sympathetic control of blood vessels.


The low energy portion of the electron spectrum established within and emitted from irradiated conducting materials.


Malignant tumours of the genito-urinary tract in childhood.


Mediastinal cysts and tumors. An analysis of 96 cases.


Complications in the management of surgical disease of the major salivary glands.


Use of isoxsuprine in uterosalpingography and uterotubal insufflation.


A method for radiologic detection of fetal maturity.


The presence of a vasoconstrictive substance in toxemia.


Prolonged remission of diarrhea due to nonbeta islet cell tumor of the pancreas by radiotherapy.


Duration of prophylactic effect of statolon against mengovirus in mice. Intraperitoneal injection of statolon into mice is known to exert a protective effect against a subsequent infection with a variety of viruses owing to stimulation of production of interferon. To study the duration of such protection, groups of mice were treated with 350 mug of statolon at 69, 55, 41, 27, 13, 6, or 1 day prior to a challenge with mengovirus. Other groups were treated with 760 mug at 1 to 6 days before challenge. Ten days after inoculation with the virus, LD(50) determinations were made for each group. Mice which received statolon 1 to 5 days before infection were significantly more resistant to the virus than nontreated controls; no protection could be demonstrated in the other groups.


Use of phenolphthale in diphosphate agar with polymyxin as a selective medium for the isolation and enumeration of coagulase-positive staphylococci from foods.


Reaction of the carcinogen 4-hydroxyaminoquinoline 1-oxide with sulfhydryl groups of proteins.


Inhibition of hexobarbital metabolism by diethylnitrosamine.


Plasma "angiotensinase" activity as a determinant of angiotensin pressor action and tachyphylaxis in the rat.


Effects of acetone on responses of a number of tissues to biogenic amines.


Studies of phosphorus metabolism by isolated nuclei. X. Nucleolar nucleosidediphosphatase activity.


Methylation of RNA by mouse organs and tumors: ionic stimulation in vitro.


Studies on messenger RNA from peanut plants: in vitro polyribosome formation and protein synthesis.


RNA-DNA hybrids formed by ribosomal RNA from a rat hepatoma.


The number of superhelical turns in mitochondrial DNA.


Viral diseases of laboratory animals.

Viral diseases of laboratory animals.


A new method for the microdetermination of free and total nonprotein-bound tryptophan in plasma.


Gluconeogenesis in mouse kidney cortex. II. Glucose production and enzyme activities in newborn and early postnatal animals.


Angiotensin infusion: a clinical evaluation as a screening test for renovascular hypertension.


Effects of the potent nephrotogenic aminonucleoside of puromycin on phospholipid metabolism in rat kidney cortex subcellular fractions.


Rabbit ileal loop response to strains of Clostridium perfringens. The ligated loop of the rabbit intestine was investigated as a possible experimental model for the study of Clostridium perfringens food poisoning. The method of preparation of the challenge inoculum was important in determining whether a given strain would provoke a response. When cultures were grown for 4 hr at 37 C in Skim Milk (Difco), 14 of 29 type A strains isolated from food-poisoning outbreaks consistently produced exudation of fluid and consequent dilation of the ileal segments. In contrast, 15 of the 18 strains derived from other sources failed to elicit a response. By use of different inoculum preparations, nearly all strains could be made to give at least an occasional positive loop reaction. Diarrhea was not obtained in rabbits by intraluminal injection into the normal ileum or by per os administration of the cultures. Lecithinase, purified and in concentrated culture supernatant fractions, failed to produce a response in the isolated ileal loops.


Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine. Thiaisoleucine-resistant mutants of Escherichia coli strain K-12 which exhibited reduced isoleucyl soluble ribonucleic acid synthetase activity were isolated. Resistance was apparently achieved by the selection of a synthetase with a 10-fold decrease in apparent affinity for thiaisoleucine. This mutation also resulted in a 2.5-fold decrease in apparent affinity for the natural substrate, l-isoleucine, and less activity than found in wild type. The mutants grew more slowly than wild type and were derepressed for three of the five enzymes in the pathways to isoleucine and valine.


Nature of unsaponifiable lipids of a Mycoplasma strain grown with isopentenyl pyrophosphate as a substitute for sterol. Mycoplasma sp., strain J, which is unable to convert mevalonic acid to isopentenyl pyrophosphate (IPP) will grow with IPP as a substitute for sterol. (14)C-labeled IPP is incorporated into its unsaponifiable lipid. This unsaponifiable lipid was separated into three (14)C-labeled fractions, all of which possess spectral and chromatographic characteristics of polyterpenes.


Insulinoma.

Insulinoma.


Reduced nicotinamide adenine dinucleotide oxidation by Thiobacillus neapolitanus and Thiobacillus strain C.


Hyperinsulinism: a report of 12 cases at the University of Iowa Hospitals.


Some biological characters of cell lines derived from normal rabbit kidney.


Bronchiolar damage and emphysema: a study in rats.


Effects of manganese on the response of aortic strips to angiotensin and norepinephrine contractions.


The absence of sympathetic role in anti-ChE-induced changes in cholinergic transmission.


Utilization of energy sources for potassium accumulation in EDTA-treated cells of Escherichia coli.


Free-radical intermediates in the reaction of the hydroxyl radical with amino acids.


Selective labeling of histamine in rat gastric mucosa: application to measurement of turnover rate.


Studies on the correlation between the clinical course of mammary carcinoma and the mode of neoplastic infiltration.


Clinical evaluation of damage to the superior cluneal nerves.


Group psychotherapy in the sixties.

Group psychotherapy in the sixties.


Biosynthesis of phosphatides of N-ethyl analogs of choline in vivo and in vitro.


Free radicals in human skin before and after exposure to light.


Photoenhancement of the electron spin resonance signal from melanins.


Studies on adrenal cortical cytochrome P-450. I. Effects of substrates and electron donors on its catalytic, spectral, and electron paramagnetic resonance properties.


Organic structural specificity and sites of coenzyme Q in succinoxidase and DPNH-oxidase systems.


Mechanism of oxidation and phosphorylation of naphthoquinol diphosphates.


The lipid composition of Mycoplasma laidlawii strain B. 1. Total lipid was extracted from Mycoplasma laidlawii strain B with chloroform-methanol mixtures and fractionated into neutral lipid, glycolipid and phospholipid components by chromatography on silicic acid. 2. Saponification of the glycolipid fraction, which represented nearly half of the total lipid, yielded two glycosides for which the structures O-alpha-d-glucopyranosyl-(1-->1)-d-glycerol and O-alpha-d-glucopyranosyl-(1-->2)-O-alpha-d-glucopyranosyl-(1-->1)-d-glycerol were established. 3. The ratio of monoglucosyl diglyceride to diglucosyl diglyceride increased with the age of the culture, though the total glycolipid concentration remained virtually constant. The glycolipid concentration was unaffected by the addition of cholesterol to the culture medium. 4. The phospholipid fraction consisted of two components, phosphatidylglucose and phosphatidylglycerol. Organisms harvested at acidic pH also contained O-amino acyl esters of phosphatidylglycerol. No lipids containing inositol could be detected.


The action of digitonin on rat liver mitochondria. Phospholipid content. 1. The amount and types of phospholipid and the fatty acid composition of the various phospholipids were examined in intact rat liver mitochondria, in mitochondria devoid of their outer membrane (preparation A) and in very small pieces derived from the disruption of the inner-membrane complexes (preparation B). The latter two preparations were obtained by digitonin treatment and carry out oxidative phosphorylation. 2. The ratio mug.atoms of phospholipid P/mg. of protein was 0.163 for intact mitochondria, decreased to 0.118 on removal of the outer membrane and increased markedly to 0.292 on disruption of the inner-membrane complex. 3. Examination of the various types of phospholipid present showed that the molar proportions cardiolipin:phosphatidylcholine:phosphatidylethanolamine were approx. 1:6:6 for intact mitochondria and 1:3:3 for preparations A and B. 4. There was a correlation between the recovery of cardiolipin and adenosine triphosphatase activity in the conversion of intact mitochondria into preparations A and B. 5. The fatty acid contents of the various types of phospholipid purified by thin-layer chromatography were identical in all three preparations. Our results show a considerably higher content of arachidonic acid and lower content of oleic acid for phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol than have previously been reported for mitochondrial phospholipids.


Fractionation of native and denatured transforming deoxyribonucleic acid from Bacillus subtilis. 1. Native DNA from Bacillus subtilis was fractionated by stepwise elution from methylated albumin, the transforming activity being confined to two out of four fractions. Partial separation of DNA active in transformation for the arginine marker from that showing activity for the histidine and tryptophan markers was achieved. 2. Partial denaturation of DNA at 90 degrees and 93.5 degrees resulted in the preferential destruction of transforming activity for the histidine and tryptophan markers. 3. Denaturation of DNA at 100 degrees followed by chromatography on methylated albumin yielded five fractions, two of which exhibited residual activity. Redenaturation at 100 degrees resulted in the interconversion of four out of the five fractions. Redenaturation of fractions labelled with (15)N and (2)H suggested the presence of a specific component that did not readily take part in the interconversions.


Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. 1. The mechanism of cycloartenol biosynthesis in leaves of Solanum tuberosum was investigated with the use of [2-(14)C,(4R)-4-(3)H(1)]mevalonic acid. 2. The (3)H/(14)C atomic ratio in cycloartenol was 6:6, the same as that in squalene; this eliminates lanosterol as a possible biosynthetic precursor of cycloartenol, and indicates that a hydrogen migration from C-9 to C-8 occurs. 3. Chemical isomerization of the cycloartenol to lanosterol ((3)H/(14)C ratio 5:6) and parkeol ((3)H/(14)C ratio 6:6) confirms the hydrogen migration from C-9 to C-8. 4. Possible mechanisms for the biosynthesis of cycloartenol and parkeol are discussed. 5. The (3)H/(14)C ratio for 24-methylenecycloartanol was 6:6, demonstrating that the hydrogen atom at C-24 is retained during alkylation of the cycloartenol side chain.


A study of the heterogeneous 37S ribonucleic acid induced by foot-and-mouth-disease virus. 1. The 37s RNA induced in baby-hamster kidney cells by infection with foot-and-mouth-disease virus was examined on sucrose gradients and by filtration through Sepharose 4B. 2. The RNA sedimented faster (37s) and as a broader band than the 35s RNA from purified virus. 3. Treatment with deoxyribonuclease, Pronase or amylase did not alter the sedimentation profile of the 37s RNA. 4. Treatment of individual fractions of the RNA with phenol, dimethyl sulphoxide or methylCellosolve did not decrease the sedimentation rate of the faster-sedimenting molecules. 5. Sedimentation in sucrose gradients of different ionic strengths or containing EDTA had no effect on the heterogeneous nature of the profile. 6. On filtration through Sepharose 4B columns, the 37s virus-induced RNA was eluted before viral RNA. 7. Only 20% of the rapidly sedimenting RNA was incorporated into complete virus particles.


Fructose diphosphatase from rabbit liver. IX. Isolation and kinetic properties of the enzyme-substrate complex.


Binding of phosphate ligands to ribonuclease A.


Ionic properties of acidic lipids. Phosphatidylinositol.


The sterols of Ochromonas danica and Ochromonas malhamensis.


Studies on the biosynthesis of the erythromycins. 3. Isolation and structure of 5-deoxy-5-oxoerythronolide B, a shunt metabolite of erythromycin biosynthesis.


Transfer ribonucleic acids from Escherichia coli treated with 5-fluorouracil.


Preparation of a mannopentaose, mannohexaose, and mannoheptaose from Saccharomyces cerevisiae mannan.


Effects on mammalian adipose tissue of fragments of bovine insulin and of certain synthetic peptides.


Studies on structures of polar dyes derived from the liver proteins of rats fed N-methyl-4-aminoazobenzene. II. Identity of synthetic 3-(homocystein-S-yl)-N-methyl-4-aminoazobenzene with the major polar dye P2b.


Studies on plasma membranes. V. On the lipid dependence of some phosphohydrolases of isolated rat-liver plasma membranes.


Studies on plasma membranes. VI. Differences in the effect of temperature on the ATPase and (Na+-K+)-ATPase activities of plasma membranes isolated from rat liver and hepatoma.


Studies on plasma membranes. VII. A leucyl-beta-naphthylamidase-containing repeating unit on the surface of isolated liver and hepatoma plasma membranes.


The lipid composition of rat-liver plasma membranes.


Comparative X-ray diffraction and electron microscope studies of isolated mitochondrial membranes.


On coupling factors of oxidative phosphorylation.


Cleavage of phycocyanobilin from C-phycocyanin.


Electron spin resonance of non-haem iron in xanthine oxidase.


Pituitary peptides. Naturally occurring analogues of porcine corticotropin.


Electron spin resonance of four human hemoglobins.


Fructose I,6-diphosphatase of mouse Ehrlich ascites tumor and its comparison with the enzymes of liver and skeletal muscle of the mouse.


Extracellular collagenase produced by Streptomyces madurae.


The intracellular localization of exonuclear and endonuclear "phosphodiesterase" activity by histochemical methods.


Kinetic studies on DNA polymerase.

Kinetic studies on DNA polymerase.


Characterization and measurement of delta-aminolaevulinate synthetase in bone marrow cell mitochondria.


The glycolytic pathway in adult liver fluke, Fasciola hepatica.


Histochemical detection of several enzymes in Cryptomphallus and Blaptica and its relation to neuromuscular transmission.


Depletion of ascorbic acid from the adrenal of the intact embryo of Gallus domesticus by adrenocorticotrophic hormone or histamine.


Studies of the metabolism of Echinococcus granulosus. X. The mechanism of production of volatile fatty acids.


Participation of potassium chloroplatinate in peroxidase-catalyzed oxidations by the extract of Japanese radish root.


Studies of metabolism in embryonic development. II. Biosynthesis of lipids in embryonated trout ova.


Alpha-glucan-phosphorylase in the striated muscle of the developing embryo of Gallus domesticus.


Quantitative thin-layer chromatography of benzyloxycarbonyl dipeptide phenylhydrazides.


Investigation of polymyxin E derivatives by thin-layer chromatography.


An improved method for the separation and removal of organochlorine insecticides from thin-layer plates.


The effects of a microlayer of silica on the retention of mandibular complete dentures.


Resistance to alveolar monocytes to rabbitpox virus following intratracheal injection of parainfluenza-3 virus.


The macrophage in allograft immunity. I. Effects of silica as a specific macrophage toxin.


Comparison of endotoxin blockade by estrogenic substances and hydrocortisone.


The histogenesis of experimental viral mouse leukaemia.


Activation of lateral geniculate neurons by electrical stimulation of superior colliculus in cats.


Mesothelioma of spermatic cord.

Mesothelioma of spermatic cord.


Granular-cell schwannoma (myoblastoma).

Granular-cell schwannoma (myoblastoma).


Biochemistry and physiology of taurine and taurine derivatives.


A method for quantitative elution of microgram quantities of steroids from silica gel layers.


Further studies on the incorporation of cell DNA into polyoma-related particles.


Antigenic relationships among frog viruses demonstrated by the plaque reduction and neutralization kinetics tests.


Further studies on RSV production form transformed cells.


Group-specific viral antigens in the milk and tissues of mice naturally infected with mammary tumor virus or Gross leukemia virus.


The inhibition of rabies virus by arabinosyl cytosine. Studies on the mechanism and specificity of action.


The self-assembly of spherical viruses with mixed coat proteins.


Relation between the adsorption to cells and antigenic properties in poliovirus particles.


Renal arterial hypertension.

Renal arterial hypertension.


Estrogen effect on spontaneous atherosclerosis. Experimental studies in white carneau pigeon.


Mono- and dimethyl phosphatidates from different subtypes of choline and ethanolamine glycerophosphatides.


Drug reactions. I. A protein contaminant causing penicillin hypersensitivity.


Dose-response relationship in angiotensin bioassay.


DNA and RNA content at successive postmitotic intervals in chick embryo fibroblasts infected with Rous sarcoma virus.


Bidimensional thin-layer chromatography of carbohydrates on silica gel impregnated with boric acid.


The basic proteins of cobra venom. I. Isolation and characterization of cobramines A and B.


Quantitative thin-layer chromatography of neutral lipids using semi-specific colorimetric and titrimetric techniques.


Systematic identification of psychotropic drugs by thin layer chromatography. II.


Systemic corticosteroids in dermatology.


Renin and erythropoietin in normotensive and in hypertensive patients.


Cancer of the urogenital tract: Wilms' tumor and neuroblastoma. Wilms' tumor.


The place of surgery in Wilms' tumors.

The place of surgery in Wilms' tumors.


Radiation therapy in Wilms' tumor.

Radiation therapy in Wilms' tumor.


Wilms' tumor. Comment. The prevention of metastases.


Changes in structural, physiological and pharmacological properties of insect excitatory nerve-muscle synapses after nerve section.


External chemical messengers. V. More functions of the pineal gland.


Hypo-hyperparathyroidism.

Hypo-hyperparathyroidism.


The effect of corticotrophin on hypothalmic-pituitary-adrenal function of children.


Viral and cellular growth and sequential increase of protein and DNA during fowlpox infection in vivo (32700).


Viomycin. Further degradative studies.

Viomycin. Further degradative studies.


Studies on DNA from low-density particles of SV40. I. Heterogeneous defective virions produced by successive undiluted passages.


Studies on DNA from low-density particles of SV40. II. Noninfectious virions associated with a large-plaque variant.


Electron microscopic study of cell fusion by HVJ virions.


Controlled double infection with unrelated animal viruses.


Role of hydrogen and disulfide bonds in polyoma capsid structure.


The sedimentation profiles of cytoplasmic polyribosomes in mammalian cells productively and abortively infected with herpes simplex virus.


Metabolic effects of hormones and drugs which may be mediated by the adenyl cyclos--cyclic 3-5 AMP system.


Pituitary adenoma. Preoperative symptomatology in a series of 260 patients.


Electron paramagnetic resonance of beef-heart ferricytochrome c.


Quantitative analysis on thin layer chromatograms: a theory for light absorption methods with an experimental verification.


Chromatographic studies on Canada balsam and some resin acids.


A rapid micro-method for the separation, identification and estimation of the purine bases: caffeine, theobromine and theophylline.


Chromatographic investigation of fatty alcohols.


Thin-layer chromatography of substituted glycosides.


Thin-layer partition chromatography for urinary metabolites of cortisol.


Identification of some naturally occurring alkyl-substituted phenols in cashew-nut shell liquid by chromatographic techniques.


Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide.


The lecithinase (alpha toxin) activity of strains of Clostridium perfringens.


The effect of glucagon and insulin on the prothrombin response to coumarin anticoagulants.


Herpes-type virus recovery from "virus-free" frog kidney tumors.


Plaque titration of herpes simplex with antibody-free liquid overlay.


Sarocoplasmic reticulum. VI. Microsomal Ca2+ transport in genetic muscular dystrophy of mice.


The effects of 6-thioguanine and endotoxin on experimental St. Louis and Japanese B encephalitis virus infections in Chiroptera.


"Alveolar" and whole lung phospholipids of newborn lambs.


Cortical modulation of transmission of the afferent volley through the lateral geniculate body.


Resting saliva of men as a reflex.

Resting saliva of men as a reflex.


Synaptic mechanism of central inhibition.


Preliminary studies on the development of a bovine parainfluenza 3 virus vaccine.


Contributions to the problem of the viral aetiology of certain acute nephrites in children.


The biochemistry of copper.

The biochemistry of copper.


Relationship between in-vitro studies of gastrointestinal muscle and motility of the alimentary tract in vivo.


The response of the internal anal sphincter in man to stimulation of the presacral nerve.


Medical management of chronic renal failure.


Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter's syndrome).


Electron paramagnetic resonance.

Electron paramagnetic resonance.


Glomus tympanicum tumors.

Glomus tympanicum tumors.


The four fundamental functions of the X-plasty.


The effect of temperature on the survival rate of Entamoeba histolytica (Schaudinn, 1903) cysts in water.


Comparative studies of chick embryo cam cell cultures infected with variola and vaccinia viruses.


Studies on the role of viruses in somatic mutation.


Effects of prostaglandins on adenosine 3',5'-monophosphate levels in fat and other tissues.


The diagnosis and treatment of pigmented villonodular synovitis.


Ethanolamine deaminase, a cobamide coenzyme-dependent enzyme. I. Purification, assay, and properties of the enzyme.


A fatal illness associated with two viruses: an intermediate adenovirus type (21-16) and influenza A2.


The effects of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse.


Nephrectomy: review of 200 cases.

Nephrectomy: review of 200 cases.


Hospital return rates and prerelease referrals.


Potential health hazards of materials used by artists and sculptors.


Coexistent diabetes mellitus and isolated ACTH deficiency: report of a case.


Cocarcinogenic effects of chemicals and radiation. BNWL-280.


The reduction of reactor effluent water radionuclide concentrations by the addition of sodium silicate to process water. BNWL-235 2.


Neurohumeral factors in experimental glaucoma.


Tartaric acid metabolism. IV. Crystalline L-malic dehydrogenase from Pseudomonas acidovorans.


Tartaric acid metabolism. 3. The formation of glyceric acid.


Tartaric acid metabolism. V. Crystalline tartrate dehydrogenase.


The isolation of an antimycin-resistant mutant of orulopsis utilis.


Studies on dihydroorotate dehydrogenase by electron paramagnetic resonance spectroscopy. II. Electron paramagnetic resonance and optical spectra and titrations.


Studies on dihydroorotate dehydrogenase by electron paramagnetic resonance spectroscopy. 3. Kinetic studies by rapid freezing.


Chemical characterization of D-lactate dehydrogenase from Escherichia coli B.


Kinetics of Escherichia coli B D-lactate dehydrogenase and evidence for pyruvate-controlled change in conformation.


Effects of various salts on the binding of indole compounds with bovine albumin.


Biosynthesis of a bacterial lipopolysaccharide. VI. Mechanism of incorporation of abequose into the O-antigen of Salmonella typhimurium.


Metallo-enzymes released from Escherichia coli by osmotic shock. II. Evidence that 5'-nucleotidase and cyclic phosphodiesterase are zinc metallo-enzymes.


Metallo-enzymes released from Escherichia coli by osmotic shock. I. Selective depression of enzymes in cells grown in the presence of ethylenediaminetetraacetate.


Prufication and properties of D-fructose 1,6-diphosphatase from swine kidney.


Role of enzyme-enzyme interactions in the regulation of glycolysis. Inactivation of D-fructos 1,6-diphosphatase by kidney cortex mitochondria.


Magnetic resonance studies on inactivated forms of creatine kinase.


Cleavage of cholesterol side chain associated with cytochrome P-450, flavoprotein, and nonheme iron-protein derived from the bovine adrenal cortex.


Continuing care--the relationship between the acute medical center and community resources.


Fetal alpha-globulin of bone serum differing from fetuin.


Hormonal control of ketosis in the chronically hypophysectomized, pancreatectomized rat.


The mechanism of action antilipolytic agents: a comparison of the effects of PGE1, insulin, tolbutamide, and phenformin on lipolysis induced by dibutryl cyclic AMP.


Effect of imidazole upon insulin secretion.


An outbread of pox in chimpanzees.

An outbread of pox in chimpanzees.


Neoplasms of ducks in Andhra Pradesh. II. A report of four intra-hepatic tumours.


Entrapment neuropathy of the central nervous system. II. Cranial nerves I-IV, VI-VIII, XII.


Clinical and laboratory findings in patients with hepatoma: a preliminary report.


The effect of caesium ions of neuromuscular transmission in the frog.


Diagnosis of granular cell myoblastoma by fine-needle aspiration biopsy.


Virus-directed protein synthesis in different animal and human cells. The relative proportions of viral gene products (viral proteins) that are synthesized in different types of animal cells infected with the same RNA virus inoculum were compared. The relative rates of synthesis of the various virus proteins late in infection were remarkably constant regardless of cell type infected. This was true in cell lines that produced only small amounts of virus and virus proteins, as well as in those that gave large yields of viruses and virus proteins.


Metabolism of cholic acid in germfree animals after the establishment in the intestinal tract of deconjugating and 7 alpha-dehydroxylating bacteria.


Fatal varicella generalisata in a child with immunopathy and neurological retardation.


The effect of some cancer-therapeutic agents on the transplantability and growth of an SV40 sarcoma in rat.


Properties of the rough microsomes.

Properties of the rough microsomes.


The ultrastructure of normal and pathological IgM immunoglobulins.


Replication of poliovirus RNA studied by gelfiltration.


A case of cylindroma of the mandible.

A case of cylindroma of the mandible.


Enzymatic determination of creatine in serum and cerebrospinal fluid.


Determination of unconjugated etiocholanolone in human plasma using gas-liquid chromatography.


The influence of hemolysins on the ATPase activity and the composition of the erythrocte membrane.


Enzymatic decrease of NADH2 in the presence of gamma-glutamylhydroxamic acid.


P Persistence of enzymatic activities in stored and geologically preserved soils.


Complications in cattle following vaccination with a combined bovine viral diarrhea-infectious bovine rhinotracheitis vaccine.


Pathogenesis and pathology of infection in calves with strains of reovirus types 1 and 2.


Pathogenesis and pathology in calves of infection by Bedsonia alone and by Bedsonia and reovirus together.


Continuous culture of mixed populations.


Synergistic action of polysorbate 80 and polymyxin B sulphate on Pseudomonas aeruginosa.


The fine structure of wound repair in an insect (Rhodnius prolixus).


Stability of diosgenin.

Stability of diosgenin.


Quantitative determination of some synthetic antiparkinsonism agents.


Determination of free salicylic acid in buffered aspirin tablets.


Separation and determination of polymyxin B in formulations.


Inhibition in IA inhibitory pathway by impulses in recurrent motor axon collaterals.


Quantitative determination of diethylstilbestrol by thin-layer chromatography.


Antitumor agents from Bursera microphylla (Burseraceae) I. Isolation and characterization of deoxypodophyllotoxin.


The effects of prostaglandins E1 and E2 on ovarian steroidogenesis.


Electron spin resonance of a gamma-irradiated single crystal of 3'-cytidylic acid.


Effects of hydration and dehydration on cyclic adenosine 3',5'-monophosphate concentration in the rat kidney.


The synthesis of collagen and protocollagen hydroxylase by fibroblastic and nonfibroblastic cell lines.


Loss of T-antigen from somatic hybrids between mouse cells and SV40-transformed human cells.


Effect of bretylium and guanethidine on transmission to sweat glands in the cat.


Viral DNA in polyoma- and SV40-transformed cell lines.


The chelate structure of Micrococcus aerogenes rubredoxin.


Cyclic adenosine monophosphate, CA++, and membranes.


Specific inhibition of virus growth in cells treated with phospholipase C.


Histoenzymatic study of the tongue mucosae in different species.


A chromatographic analysis of the lipid of cat and dog kidneys.


The African custom of tooth mutilation in America.


The effect of irradiation on the cultured human leucocytes with special reference to the survival after large doses.


Radioautographic study on RNA labeling in rat liver parenchyma during DAB carcinogenesis.


The induction of benign and malignant liver tumors by urethan in newborn rats.


The relationship of hepatoma in rainbow trout to aflatoxin contamination and cottonseed meal.


The foetal adrenal cortex in the human. Its ultrastructure at different stages of development and in different functional states.


Ulcerogenic tumor of the pancreas diagnosed preoperatively by bioassay.


Unusual locations and manifestations of glomus tumors (glomangiomas).


Can breast carcinoma be anticipated? A follow-up of benign breast biopsies. 110 women who had undergone biopsy for benign lesions of the breast were studied for subsequent development of breast carcinoma over the following 16-20-period.  10 women in the study developed carcinoma in the same or opposite breast within 16-20 years, a rate of incidence 480% greater than among the general population of women of the same age.  Average interval time from biopsy to appearance of malignant tumors was 9 years.  The original biopsies were studied and categorized with a view to isolating pathologic factors which might indicate high risk.  No factor could be associated with subsequent carcinoma development.  The incidence of carcinoma appeared related to years of risk only.  It is recommended as a result of this study that all women who undergo biopsies for benign breast lesions should have life-long followup since they seem to be at high risk.


On the theory of silicosis. IV. The topochemical interaction.


Bronchial adenoma.

Bronchial adenoma.


Role of silica in progressive massive fibrosis. In coal workers' pneumoconiosis.


Successful metyrapone therapy of the ectopic ACTH syndrome.


Chemical biology of in vivo and in vitro wounds.


Proteases and antiproteasic substances in the inflammatory response.


Heparin: molecular weight and degradation studies.


Liver microsomal inorganic pyrophosphate-glucose phosphotransferase: alterations in activity-pH profiles by cortisone in vivo.


On the reversibility of the first segment of glycolysis in ascites tumor cells.


Sialic acid contents and controls of normal and malignant cells.


Fasting in obese females. II. Plasma renin activity and urinary aldosterone.


Virology in a general hospital.

Virology in a general hospital.


Friedlander's pneumonia. A report of 11 cases and appraisal of antibiotic therapy.


Biological studies on an anti-androgen (SH 714).


Comparative enzyme histochemistry of immature and mature stages of Fasciola hepatica.


Estrogens and gastric secretion.

Estrogens and gastric secretion.


Studies on the mechanism of action of the adrenocorticotropic hormone in fat mobilization.


Rapid liberation of potassium ions from brain mitochondria.


Visualization of acyl phosphatase after zone electrophoresis and thin-layer gel filtration.


Natural fatal infection of an owl monkey (Aotus trivirgatus) with Herpes T virus.


Intervertebral discolysis with collagenase.


Diagnosis and treatment of entrapment neuropathies.


Studies on poliovirus inhibitors in sera of domestic animals. I. Distributions and properties of poliovirus inhibitors in bovine and equine sera.


Effect of phytohemagglutinin on ascites tumor and SV40 induced sarcoma of hamsters.


Investigative studies with quartz rods for high energy laser transmission.


Peripheral nerve injuries--diagnosis and treatment.


Morphology and development of viruses in mammary carcinoma of mice.


Physical chemical properties of SV40 induced tumor ("T") antigen.


Biological membranes: regulatory functions.


Preoperative radiation.

Preoperative radiation.


Inhibitory effect of hypothalamic implants of corticosterone on adrenocortical response to auditory stimulation.


The effect of transient renal anoxia and portacaval transposition on canine arterial blood pressure.


Adrenocortical response to craniocerebral trauma.


Ulcerative colitis in the elderly patient.


Tumorigenicity of the antigen-forming defective virions of imian virus 40.


Effect of magnesium trisilicate on the infectivity of tobacco mosaic virus.


The effect of polycations on the interaction of viral RNA with mammalian cells: studies on the infectivity of single- and double-stranded poliovirus RNA.


Recovery of SV40 virus with genetic markers of original inducing virus from SV40-transformed mouse cells.


Virus isolations from children with acute respiratory illness. A comparison of a family study group and a group of nursery infants.


Parasitic serologic studies in Somaliland.


Simian hemorrhagic fever. 3. Isolation and characterization of a viral agent.


Plasma cortisol levels in protein-calorie malnutrition.


Further studies of the Xavante Indians. IX. Immunologic status with respect to various diseases and organisms.


Influence of growth hormone on results of allergization in guinea pigs.


Systemic herpes simplex infection in a newborn treated with intravenous idoxuridine.


Glomus tumour of palate.

Glomus tumour of palate.


Déjà vu--as related to diagnostic categories in psychiatric and neurosurgical patients.


Localisation of human placental factor in malignant teratoma of testis.


A case of renal dysplasia and relation to "bilateral nephroblastomatosis".


The effects of bradykinin, angiotensin and acetylcholine on the bovine adrenal medulla. 1. The response of the adrenal medulla to the intra-arterial injection of angiotensin, bradykinin and acetylcholine and to splanchnic nerve stimulation has been investigated in day-old and 3- to 18-month-old calves and in adult cats.2. Bradykinin and angiotensin had no appreciable effect on catecholamine release in the day-old calf nor did these peptides potentiate the response of the gland to acetylcholine.3. In older calves the response of the gland to bradykinin and angiotensin was marginally above the control output, whereas acetylcholine and splanchnic nerve stimulation caused a 10-100 fold increase in the rate of secretion. The response to acetylcholine but not to the peptides was related to the dose administered.4. The adrenal medulla of the cat was stimulated by angiotensin and bradykinin but the maximum amounts released by the peptides were much smaller than the discharge elicited either by splanchnic nerve stimulation or by acetylcholine. No dose-response relationship could be found for either adrenaline or noradrenaline released by angiotensin, or for noradrenaline released by bradykinin. The slight increase in adrenaline output which followed the injection of bradykinin was dependent on the dose but the slope of the curve (b = 0.161) was much less than that for acetylcholine (b = 0.636).


The effect of oestrogen and progesterone on the pressor action of angiotensin in the rat. 1. A comparison was made between the pressor responses to angiotensin in rats during different stages of the oestrous cycle, pregnancy, pseudopregnancy and also following oestrogen and progesterone treatment.2. No evidence for an effect of oestrogen on the response to angiotensin was found.3. Pregnancy and pseudopregnancy were found to diminish the pressor response to angiotensin.4. Progesterone treatment also diminished the response to angiotensin.5. It is suggested that the decrease in pressor response in pregnancy and pseudopregnancy is attributable to progesterone.6. The possible mode of action of progesterone is discussed.


Electrical activity observed in guinea-pig olfactory cortex maintained in vitro and its modification by changes in the ionic composition of the bathing medium.


Anti-microbial drugs in animal feeds.

Anti-microbial drugs in animal feeds.


Termination and functional organization of the ventral spino-olivocerebellar path. 1. The spino-olivocerebellar path ascending through the ventral funiculus (VF-SOCP) was investigated in decerebrate cats with the cord transected in the third cervical segment except for the left ventral funiculus. The climbing fibre responses evoked in Purkinje cells were studied by recording from single cells and by recording the mass activity at the cerebellar surface or in the molecular layer.2. In the spinal cord the forelimb component of the VF-SOCP occupies a medial part and the hind limb component a lateral part of the ventral funiculus.3. The main projection of the limb nerves through the VF-SOCP is to the lateral two thirds of the vermis of the anterior lobe. The projection area consists of three sagittally arranged bands: a lateral band receiving olivary axons activated exclusively from the ipsilateral hind limb, an intermediate band receiving olivary axons activated bilaterally from the hind limbs, and a medial band receiving olivary axons activated bilaterally from the forelimbs. Some olivary neurones are activated from all four limbs.4. The latency of the climbing fibre responses was about 22 msec on stimulation of ipsilateral hind limb nerves and about 20 msec on stimulation of ipsilateral forelimb nerves. The responses evoked from contralateral nerves had a latency which was about 3 msec longer than the latency of the corresponding ipsilateral responses.5. The olivary neurones were usually activated from all tested muscle and skin nerves in the limb(s) constituting the receptive field. Cutaneous afferents and groups II and III muscle afferents were responsible for the excitation elicited by single shock stimulation of the nerves. Brief repetitive stimulation revealed additional activation from mainly Ib, but also Ia, afferents in ipsilateral hind limb nerves.6. Natural stimulation of receptors evoked responses in about half of the olivary neurones tested. The responses were elicited by strong pressure against deep structures. Inhibitory effects were seldom observed.


Virus etiologic studies of human leukemia.


Neurologic manifestations and complications of lymphoma.


Neutron activation analysis of potassium in biologic material with the use of a new separation method .


O: Renin-angiotensin system in normal and toxemic pregnancies. IV. Inactivation of angiotensin in toxemic pregnancy.


Kidney.

Kidney.


Regulation of the adenohypophysis.

Regulation of the adenohypophysis.


Oculocutaneous metastases from carcinoma of the urinary bladder. Case report and review of the literature.


Solid-cystic hidradenoma of the skin. Clinical and histopathologic study.


Environmental carcinogens.

Environmental carcinogens.


Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. I. Neurologic, genetic, and electrophysiologic findings in hereditary polyneuropathies.


Neuromuscular changes with alloxan hyperglycemia. Electrophysiological, biochemical, and histological study in rats.


Antibiotic topical spray in a simulated combat wound. II. Neomycin-bacitracin-polymyxin B, and penicillin.


Cytological features of viral respiratory tract infections.


Intracranial tumours in infancy.

Intracranial tumours in infancy.


The Doman-Delcato treatment of neurologically handicapped children.


A method of preparing adrenal cell suspensions and its applicability to the in vitro study of adrenal metabolism.


Suppression of pituitary gland hormone content by pituitary tumor hormones.


Inhibition of inosine monophosphate-dehydrogenase by thyroid hormones in vitro.


Effects of steroids and ACTH on pyruvate and acetate metabolism by the sheep adrenal cortex in vitro.


Avian helper cell and its role in the in vitro transfer of Rous virus (Prague strain) genome from rat tumour cells to chick cells.


Viral group specific antigen in mammalian Rous tumours detected by complement-fixation and fluorescent antibody tests.


Minute chromatin bodies in two mouse tumours induced in vivo by Rous sarcoma virus.


The energy-linked incorporation of diphosphopyridine nucleotide into rat liver mitochondria. Requirements for incorporation.


Allosteric properties of nucleoside diphosphatase and its identity with thiamine pyrophosphatase.


Biosynthesis of mannophosphoinositides by Mycobacterium phlei. Enzymatic acylation of the dimannophosphoinositides.


On the mechanism of phenethyl alcohol-induced loss of polyribosomes and their re-formation after reversal in rat hepatoma cells.


The metal complexes of peptides and related compounds. 3. Copper(II) complexes of glycylglycylglycine in 3.0 M (Na)ClO4 medium.


Kinetic studies on the inhibition of a (D(-)-specific lactate dehydrogenase by adenosine triphosphate.


Participation of aminoacyl transfer ribonucleic acid in aminoacyl phosphatidylglycerol synthesis. II. Specificity of alanyl phosphatidylglycerol synthetase.


Respiratory activity of intact, isolated parenchymal cells from rat liver.


Structural studies on nicotinamide adenine dinucleotide-linked L-glycerol 3-phosphate dehydrogenase crystallized from rat skeletal muscle.


A new enzyme with the glycolytic function of pyruvate kinase.


Effect of dexamethasone on ACTH release induced by lysine vasopressin in man; time interval between dexamethasone and vasopressin injection.


Adrenal hyperplasia--a case report of delayed onset of the congenital form or an acquired form.


Metabolic fate of histidylleucine, a metabolite of angiotensin I.


Thiamine monophosphate, a normal constituent of rat plasma.


Studies on the mode of action of diphtheria toxin. VI. Site of the action of toxin in living cells. Using the technique of radioautography, it has been shown that a probable maximum of only 25-50 molecules iodine-125-labeled toxin per cell is bound by human HeLa cells treated with approximately 10(7) molecules of toxin per cell, or just under one saturating dose. Radioautographs of sections from labeled cells locate most if not all of the toxin molecules fixed to the outer cell membrane. Under identical conditions far less label is taken up by mouse L cells. It is probable that the resistance of this species to diphtheria toxin can be accounted for in terms of the failure of mouse cells to bind the toxin protein. The irreversible inhibition of protein synthesis in a living cell culture by a few molecules of toxin located at the cell surface is discussed in relation to the known interaction between toxin, NAD, and transferase II in mammalian cell extracts.


Sites of action of sodium depletion on aldosterone biosynthesis in the dog. Secretion of cortisol, corticosterone, and aldosterone was measured in vivo in normal and sodium-depleted hypophysectomized dogs. Biogenesis of steroids was then measured in vitro with outer slices of the adrenals of the same dogs. In some studies, metyrapone or puromycin was added. In vivo, sodium depletion stimulated the production of cortisol, corticosterone, and aldosterone. In vitro, tissues from sodium-depleted animals released more aldosterone, but less corticosterone than those from sodium-replete controls. The results are interpreted to indicate that (a) biosynthesis of aldosterone is regulated at at least two sites in the biosynthetic pathway. The final conversion, that of corticosterone to aldosterone, is stimulated by sodium depletion. This effect persists for at least 3 hr while slices from sodium-depleted dogs are incubated in vitro. Stimulation at this site is thus relatively stable in vitro; its activation by sodium depletion is not inhibited by puromycin in the dog. Stimulation at this site can explain, at least in part, the increased effectiveness of adrenocorticotropin (ACTH) on aldosterone biogenesis during sodium depletion.(b) the earlier site at which sodium depletion stimulates the secretion of aldosterone is "above" the position of desoxycorticosterone in the pathway; it is probably at the conversion of cholesterol to pregnenolone. Stimulation at this site is quickly lost during incubation of adrenal slices. It is thus relatively unstable in vitro; its activation by sodium depletion is inhibited by puromycin in the dog.


Effect of calcium and vitamin D3 upon the fecal excretion of some metals in the mature male rat fed a high fat, cholesterol diet.


Schistosomal granuloma with muco-epidermoid carcinoma of parotid gland.


Soft-tissue sarcomas of infants and children: a clinicopathologic study of 135 cases.


Herpes simplex encephalitis: report of two fatal cases in Singapore.


Atypical adrenal hyperfunction: in vivo studies and incubations of adrenal tissue with 4-14C progestrone.


The electron spin resonance spectra of chemically modified lysozyme irradiated in the solid state.


Functioning of the hypothalamo-pituitary-adrenal system during postnatal development in rats.


The effect of corticosteroid concentrations in the blood of gravid rats on the adrenocorticotropic function of hypophysis of the fetus.


Morphological changes in the hypothalamo-pituitary-adrenal system during early postnatal period in rats.


Histostructure of adenohypophysis of human fetuses and contents of somatotropic and adrenocorticotropic hormones.


Collagenases in mammalian cells.

Collagenases in mammalian cells.


Observations on the use of live and inactivated virus vaccines against sheep pox.


A successfully treated case of Pseudomonas endocarditis, with review of the literature.


Hepatorenal syndrome. A review.

Hepatorenal syndrome. A review.


Some observations on hydrolysis of oestrogen conjugates in bovine urine. Formation of oestratetraenol.


Compression of the posterior tibial nerve. (The tarsal tunnel syndrome).


Enzymic synthesis of vitamin B 12.

Enzymic synthesis of vitamin B 12.


The possible failure of 15N to affect fhe ESR spectrum of the non-heme iron proteins of Azotobacter vinelandii.


Lysis of spheroplasts of Escherichia coli by a non-ionic detergent.


Enzyme localization in the inner and outer mitochondrial membranes.


Pseudo-allosteric behavior of firefly luciferase.


Changes of plasma renin concentration during pressor infusions of renin in the conscious dog: the influence of dietary sodium intake.


Chemoreception and efferent sensory impulses in Lumbricus terrestris Linn.


Biochemical studies of purine catabolism in Ceratitis capitata.


On the phospholipids of Ascaris lumbricoides.


Immunochemical studies on Salmonella. 13. Chemical changes appearing on the specific polysaccharide of S. cholerae suis (6-2,7) after its conversion by phage 14(6,7).


Pulsed incorporation of 32P by the soluble oscillating glycolytic system from Saccharomyces carlsbergensis.


Somatic afferent input to posterior thalamic neurones and their axon projection to the cerebral cortex in the cat. 1. A technique of reversible block of synaptic transmission through the dorsal column nuclei and the trigeminal nucleus caudalis (n. caudalis) has been employed to assess the somatic afferent input to individual posterior thalamic neurones in the cat. The axon projection to the cerebral cortex of these neurones has been identified by antidromic activation following cortical stimulation.2. Unitary responses in the nucleus ventralis posterolateralis (VPL) evoked by cutaneous stimulation were abolished or depressed following block of transmission in the dorsal column nuclei. Block in n. caudalis, however, depressed unitary responses in nucleus ventralis posteromedialis (VPM) evoked by facial skin stimulation in less than 10% of cells.3. A more complex source of the somatic input to the posterior nuclear region of the thalamus (PO) was found. It was most commonly noted that PO unitary activity evoked by cutaneous stimulation of the face was unaffected by block of synaptic transmission in n. caudalis. No uniform effect was observed on unitary responses in PO evoked by limb stimulation when transmission in the dorsal column nuclei was blocked.4. Antidromic activation from the cerebral cortex was seen in 69% of ventrobasal neurones. Most cells (66%) had ;antidromic cortical fields' restricted to a region consisting of a third to a half of the specific somatic projection areas. In 10% of cells evidence was obtained for discontinuous cortical ;antidromic fields' suggesting subcortical bifurcation of the projecting axon.5. An axon projection to the cortex was found in 35% of PO cells, about half of which projected only to specific somatic projection areas. Evidence for subcortical branching of the axon was obtained for seven PO cells.


On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses. 1. The relationship between the quantal content of end-plate potentials (e.p.p.s) and the bathing [Ca] and [Mg] was determined at neuromuscular junctions in the rat diaphragm in vitro.2. E.p.p.s were recorded intracellularly from preparations exposed to solutions with [Ca] between 0.05 and 10 mM and [Mg] between 0.1 and 12.5 mM. The quantal content of e.p.p.s was increased by raising the [Ca] over this range and decreased by raising the [Mg]. There appeared to be competition of Mg with Ca at three sites in the nerve terminal membrane.3. A kinetic scheme based on competition of Ca and Mg at three sites could quantitatively explain the effects of Ca and Mg upon the quantal content of e.p.p.s and also the effects of these ions upon miniature end-plate potential frequency.


Electron microscopy of siliceous spicules from the freshwater sponge Heteromyenia.


Frequencygrams of spindle primary endings elicited by stimulation of static and dynamic fusimotor fibres. 1. Frequencygrams of cat spindle primary endings, obtained by the method described by Bessou, Laporte & Pagès (1968), were elicited by the stimulation of single static and dynamic fusimotor fibres.2. Stimulation of static fibres by single stimuli may elicit: (i) no response, (ii) responses of small amplitude, (iii) responses of large amplitude with a pause after the rising phase.3. Stimulation of static fibres by repetitive stimuli gives frequencygrams resembling records of tetanic contraction of skeletal muscle. At a frequency of stimulation of 180-200/sec periodic oscillations are perceptible on the plateau of the frequencygram.4. Stimulation of dynamic fibres by single stimuli may elicit: (i) no response, (ii) responses smaller and longer than the responses given by static fibres.5. When the muscle is stretched the amplitude of the responses elicited by dynamic fibres decreases whereas the amplitude of the responses given by static fibres increases.6. Frequencygrams obtained by repetitive stimulation of dynamic fibres show periodic oscillations only at low rates of stimulation. At rates of stimulation higher than the minimal rate giving frequencygrams with a smooth contour, the amplitude of the frequencygram increases.


Bilateral diffuse Wilms tumor: a 5-year survival.


Intramural lesion of esophagus.

Intramural lesion of esophagus.


Erythropoietin alterations in human genitourinary disease states: correlation with experimental observations.


Intensive antibiotic treatment for burns complicated by Pseudomonas infection.


Toxicity of mercury perchloride when used as an anti-cancer agent in colorectal surgery.


Pyrophosphate in the 5' terminal position of a viral ribonucleic acid. A pancreatic ribonuclease digest of carbon-14-labeled Satellite Tobacco Necrosis Virus RNA was fractionated, according to charge, by column chromatography. Individual fractions were dephosphorylated with alkaline phosphomonoesterase and rechromatogramed. The fraction originally containing oligonucleotides with seven negative charges separated into two components corresponding to five and two negative charges, respectively, and therefore must have contained a terminal trinucleotide 5'-pyrophosphate, in addition to the internal hexanucleotides. Other fractions when similarly treated were found to contain only internal oligonucleotides.


Ascorbic acid for treatment of feline rhinotracheitis.


Extent of release and elimination of noradrenaline at peripheral adrenergic nerve terminals.


Photochemistry of the DNA-acridine dye complexes.


Clinical diagnosis of hepatoma. Importance of bruit.


Factors affecting the toxicity and metabolism of OMPA (octamethylpyrophosphoramide) in rats.


Release of renin from dog kidney cortex slices in vitro.


Newer and second-line drugs in the treatment of drug-resistant tuberculosis in children.


Satellitism and related phenomena in plant and animal viruses.


A syndrome of retarded development with characteristic appearance.


Wilms' tumor and congenital heart disease: report of a case and family.


Sex-dependent vascular changes in young, adult, aged, and hypertensive rats.


Biological effects of urban air pollution. V. A study of effects of Los Angeles atmosphere on laboratory rodents.


Production of herpes simplex virus by HeLa cells treated with 5-fluoro-2'-deoxyuridine.


Mixed malignant tumor of the liver in an adult. Case report and review of some features.


Study of chloroquine toxicity and a drug-induced cerebrospinal lipodystrophy in swine.


Generalized cytomegalic inclusion disease of the newborn. Localization of inclusions in the kidney.


Marek's disease. II. Propagation of the Connecticut-A isolate in cell cultures.


Avian influenza A and paramyxo viruses complicating respiratory disease diagnosis in poultry.


Hexokinase activity and glycolytic capacity of plasma membranes of hepatomas.


Enzymes and intermediates of the pentose phosphate pathway in liver hepatomas.


Brucella abortus in fresh cream and cream products.


A continuous spectrophotometric method for the determination of leucine aminopeptidase.


Determination of urinary testosterone and epitestosterone in men, women, and children.


Production of Arneil-Dekanski factor in vitro by plasma of renal hypertensive rats.


Lactic dehydrogenase activity in neuron-free spinal cord tissue obtained by a new method.


Clonal analysis of embryonic Chinese hamster cells transformed by Schmidt-Ruppin RSV in vitro.


The pineal gland.

The pineal gland.


Protein and RNA metabolism of squid axons (Dosidicus gigas).


Adsorption, penetration and uncoating of herpes simplex virus.


Isolation of a transmissible agent resembling rubella virus from an apparently healthy human embryo lung cell culture.


Evidence for a host cell component in vesicular stomatitis virus.


Production of infectious RNA and serum-blocking antigen by poliovirus temperature-sensitive mutants.


Pepsin digestion of virus particles in canine hepatitis using epon-embedded material.


Influence of adrenalectomy and ureteral ligation on the consequences of renal artery constriction in rats.


Virus inactivation on clay particles in natural waters.


DW 75: a new and potent synthetic corticotrophin analogue.


Synovial sarcoma in the scapular region of a 12-year-old child: a case report.


Enanthems associated with uncommon viral syndromes.


Triple antibiotic tulle.

Triple antibiotic tulle.


Monkey pox. I. Clinical, virologic and immunologic studies.


Comparison of two lots of immune serum globulin for prophylaxis of infectious hepatitis.


Effects of angiotensin, norepinephrine and renal artery constriction on erythropoietin production.


Extra-renal and renal control of erythropoietin production.


Malignant lymphoproliferative diseases: interactions between immunological abnormalities and oncogenic viruses.


Growth and physiological development during adolescence.


Histochemical studies on the mamillary body of the rabbit.


Comparison of lesions in acute and chronic African swine fever.


The antigenic relationship of bovine and human strains of parainfluenza-3 virus demonstrated by immunodiffusion.


Studies on the pathogenesis of infectious bovine rhinotracheitis following aerosol exposure.


Mode of action and base specificity of a nuclease from the silkworm.


Incorporation of radioactivity from methionine-methyl-14C into phospholipids by Nocardia polychromogenes.


Comparative studies on the glucose oxidases of Aspergillus niger and penicillium amagasakiense.


Adenosine triphosphate and pyrophosphate dependent phenylalanine racemase of Bacillus brevis Nagano.


Cancer of the urogenital tract: Wilms' tumor and neuroblastoma. Neuroblastoma.


Aflatoxin risks and control measures.

Aflatoxin risks and control measures.


Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice. The resistance of mice to encephalomyocarditis (EMC) virus was markedly decreased by prior exposure to whole body X-irradiation. In contrast to non-irradiated controls, the course of EMC virus infection in X-irradiated animals was characterized by (a) an enhanced mortality, (b) shortening of the incubation period, (c) higher levels of virus in the blood during the viremic phase and persistence of the viremia until death, (d) failure to develop detectable serum levels of neutralizing antibody, and (e) the earlier appearance and higher levels of virus in brain and heart tissue. The level of interferon in the serum during the course of infection was similar in both groups. The administration of relatively small quantities of anti-EMC virus neutralizing antibody to X-irradiated mice during the early phases of the infection with EMC virus restored their resistance to levels comparable to nonirradiated animals. An alteration of local organ defense mechanisms in the central nervous system could not be demonstrated. It is proposed that (a) the inability of the X-irradiated animal to elaborate specific neutralizing antibody was a critical determinant in their failure to clear the viremia, (b) this increase in the level and duration of the viremic phase resulted in the exposure of target organs to a greater inoculum of virus, and (c) the enhanced mortality observed in irradiated mice reflected this greater target organ involvement. The experimental model presented, therefore, suggests that the immunologic response is a critical determinant of host resistance during this primary systemic virus infection.


Cancer of the urogenital tract: Wilms' tumor and neuroblastoma. Comment. Cure and the growth rate of childhood tumors.


Studies on leukocyte metabolism. I.

Studies on leukocyte metabolism. I.


Association of recurrent herpes simplex with neuralgia.


Interrelationship between angiotensin and catecholamines.


Passive cellular immunity in tumor-bearing mice.


Comparative studies on the structure and properties of two selected strains of Japanese encephalitis virus.


Chainin: a new methylpentaene antibiotic from a species of Chainia.


Gliomas of the quadrigeminal plate and eye movements.


The future of vaccines against viral diseases.


Paget's disease of perianal skin.

Paget's disease of perianal skin.


Autoimmunity in oral diseases, with special reference to recurrent oral ulceration.


Cyanovinyl phosphate: a prebiological phosphorylating agent? Cyanovinyl phosphate may be prepared by the addition reaction of phosphate to cyanoacetylene. Kinetic studies have established that cyanovinyl phosphate undergoes a slow pseudo-first-order hydrolysis in aqueous solution. Cyanovinyl phosphate converts uridine to uridine monophosphate and phosphate to pyrophosphate.


Chemical mediators in the central nervous system.


Cytological studies on host-parasite relations in experimental leprosy of mice.


Plasma angiotensinase activity in rabbits with experimental renal hypertension.


Structure of simian virus 40. 3. Alkaline degradation of the virus particle.


Influence of reticuloendothelial function on the growth of transplantable rat ascites hepatoma (AH-130).


Oxidation of methylmalonate semialdehyde to propionyl coenzyme A in Pseudomonas aeruginosa grown on valine.


Pleomorphic adenoma of the palate. A case report.


The treatment of mixed parotid tumours. A report of 183 cases.


Current concepts of burn injury. 3.

Current concepts of burn injury. 3.


Maturity as a biological concept.

Maturity as a biological concept.


Electrical pacing of the heart with observations on the single and paired electrical stimuli during acute reversible experimental heart failure in the anaesthetized dog.


The cytochrome oxidase activity of pneumoconiotic tissue as parameter of cellular hypoxia.


A case of orf (ecthyma contagiosum; contagious pustular dermatitis) contracted by a human from a wild Alaskan mountain goat.


Varicella pneumonia in pregnancy.

Varicella pneumonia in pregnancy.


Cytochemical studies on the second gradient axis of fertilized oyster eggs. IV. On the activity of ATPase and reduced NAD dehydrogenase.


Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.


Histometrical estimation of the corticotrophin secreting cells in the adenohypophysis of bilaterally adrenalectomized rats.


Studies on methionyl transfer RNA synthetase. 1. Purification and some properties of methionyl transfer RNA synthetase from Escherichia coli K-12.


Partial antagonism of experimental botulinal intoxication.


Biotransformation studies on 1-chloro-2,3-propanediol dinitrate.


Neuroblastoma: a viral etiology?

Neuroblastoma: a viral etiology?


Development and evaluation of a sampling device for the analysis of pharmaceutical aerosols.


Effect of mescaline on nicotinamide adenine dinucleotide synthesis in the central nervous system.


Treatment of diseases of the testes affecting growth and development.


Genetic aspects of tumors of the nervous system. II.


Aldosterone deficiency in chronic renal failure.


Daunomycin pharmacological activity at the cellular level.


Relation of pock size on chorioallantoic membrane to antigenic type of herpesvirus hominis.


Human cytomegalovirus, observations of intracellular lesion development as revealed by phase contrast, time-lapse cinematography.


Studies of adenovirus type 3 infection treated with methisazone and trifluorothymidine.


Hemagglutinin of rabies and some other bullet-shaped viruses.


Experimental infections of chimpanzees with human rhinovirus types 14 and 43.


The influence of serotonin on oxidative metabolism of brain mitochondria.


Histochemical investigation of hepatic adenosine triphosphatase and glucose-6-phosphatase activity in hemorrhagic shock.


Histamine hypersensitivity of mice induced by 5'-AMP.


Yellow fever vaccine. I. Development of a vaccine seed free from contaminating avian leukosis viruses.


Pyelonephritis in the mouse. 3. Therapeutic experiments.


Reovirus type 2: production of and sensitivity to interferon in human amnion cells.


A variant of parainfluenza type 2 virus.


Two cases of metastasizing scirrhous gastric carcinoma simulating idiopathic retroperitoneal fibrosis.


Induction of the interferon system by various inducers.


New methods of production and partial purification of an antiviral substance from Penicillium cyaneo-fulvum.


Screening for disorders of amino acid metabolism by thin-layer high voltage electrophoresis.


Beta-alaninuria following human renal allotransplantation.


Segregation of a nonhemadsorbing African swine fever virus in tissue culture.


High mortality in a Florida swine herd infected with the encephalomyocarditis virus. An accompanying epizootiologic survey.


Is the tonic decerebrate inhibition of reflex paths mediated by monoaminergic pathways?


The effect of reserpine on transmission in the spinal cord.


Peripheral neuropathies.

Peripheral neuropathies.


Histochemical mapping of succinic dehydrogenase and cytochrome oxidase in the diencephalon and basal telencephalic centers of the brain of squirrel monkey (Saimiri sciureus).


Fatty acid composition of serum cholesteryl ester fractions isolated by thin-layer chromatography.


Hereditary brachial and cranial neuritis genetically linked with ocular hypotelorism and syndactyly.


Differences in the subcellular localization of choline, acetylcholine and atropine taken up by mouse brain slices in vitro.


Steroid therapy of non-infantile (childhood) myoclonic epilepsy.


Effects of nervous system lesions on phantom experience in amputees.


Induction of mannitol dissimilation in Mycobacterium phlei.


ATPase activity of membrane ghosts obtained from mitochondria.


Sensitivity of Klebsiella bacilli to antibiotics.


Resistance of Shigella sonnei to antibiotics.


Multiple antibiotic resistance of Shigella flexneri 6.


The orf viruses in man and animals.

The orf viruses in man and animals.


Colorimetric personal dosimeter for hydrazine fuel handlers.


Sorbents and catalysts for respirator cartridges and gas mask canisters.


Immunochemical analysis of Mycoplasma pneumoniae. 2. Properties of chloroform-methanol extract from M. pneumoniae.


Laser destruction of experimental tumors: state of the art and protection of personnel.


Metal and mineral concentrations in lungs of bituminous coal miners.


Effect of antibiotics on vascular permeability.


Influence of antibiotics on pregnancy. Cumulative study on trichomycin administered patients.


Ultrastructural and cytochemical observations on B-16 and Harding-Passey mouse melanomas. The origin of premelanosomes and compound melanosomes.


Drugs affecting transmitter release from motor nerve terminals.


I. Organisation of spinal units. History of the National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury.


The organisation of a Spinal Injuries Unit at Royal Perth Hospital, Perth, Western Australia.


Peripheral neuropathy in chronic disease of the respiratory tract.


Postappendectomy fistula due to residual fecalith.


Hepatic effects following abdominal irradiation in children: detection by Au198 scan and confirmation by histologic examination.


N6-(Delta 2-isopentenyl)adenosine: biosynthesis in vitro by an enzyme extract from yeast and rat liver.


Community psychiatry.

Community psychiatry.


Involuntary movements in multiple sclerosis.


Cytomegalic inclusion-body disease associated with acquired autoimmune haemolytic anaemia.


The effect of propranolol on circulatory adaptations to volume and pressure loads.


Case records of the Angell Memorial Animal Hospital.


Fragility of liver mitochondria in ethanol-fed rats.


Identification and cobamide coenzyme-dependent formation of 3,5-diaminohexanoic acid, an intermediate in lysine fermentation.


Properties of the nicotinamide adenine dinucleotide-binding sites of L-alpha-glycerophosphate dehydrogenase.


Influence of added pyruvate on brain metabolism. A Pasteur-like effect, reversible by electrical stimulation.


Allosteric interactions of a regulatory nicotinamide adenine dinucleotide-specific glutamate dehydrogenase from Blastocladiella. A molecular model for the enzyme.


A soluble cytochrome P-450 functional in methylene hydroxylation.


Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis.


The biogenesis of mitochondria. 3. The lipid composition of aerobically and anaerobically grown Saccharomyces cerevisiae as related to the membrane systems of the cells. The growth conditions known to influence the occurrence of mitochondrial profiles and other cell membrane systems in anaerobic cells of S. cerevisiae have been examined, and the effect of the several growth media on the lipid composition of the organism has been determined. The anaerobic cell type containing neither detectable mitochondrial profiles nor the large cell vacuole may be obtained by the culture of the organism on growth-limiting levels of the lipids, ergosterol, and unsaturated fatty acids. Under these conditions, the organism has a high content of short-chain saturated fatty acids (10:0, 12:0), phosphatidyl choline, and squalene, compared with aerobically grown cells, and it is especially low in phosphatidyl ethanolamine and the glycerol phosphatides (phosphatidyl glycerol + cardiolipin). The high levels of unsaturated fatty acids normally found in the phospholipids of the aerobic cells are largely replaced by the short-chain saturated acids, even though the phospholipid fraction contains virtually all of the small amounts of unsaturated fatty acid present in the anaerobic cells. Such anaerobic cells may contain as little as 0.12 mg of ergosterol per g dry weight of cells while the aerobic cells contain about 6 mg of ergosterol per g dry weight. Anaerobic cell types containing mitochondrial profiles can be obtained by the culture of the organism in the presence of excess quantities of ergosterol and unsaturated fatty acids. Such cells have increased levels of total phospholipid, ergosterol, and unsaturated fatty acids, although these compounds do not reach the levels found in aerobic cells. The level of ergosterol in anaerobic cells is markedly influenced by the nature of the carbohydrate in the medium; those cells grown on galactose media supplemented with ergosterol and unsaturated fatty acids have well defined mitochondrial profiles and an ergosterol content (2 mg per g dry weight of cells) three times that of equivalent glucose-grown cells which have poorly defined organelle profiles. Anaerobic cells which are low in ergosterol synthesize increased amounts of squalene.


The detection and estimation of pentachlorophenol in natural latex by thin-layer chromatography.


The occurrence in yeast of cytoplasmic granules which resemble microbodies.


The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractions. Improved, largely automated methods are described for the purification and analysis o peroxisomes, lysosomes, and mitochondria from the livers of rats injected with Triton WR-1339. With these new methods, it has become possible to obtain, in less than 6 hr and with reliable reproducibility, mitochondria practically free of contaminants, as well as the rarer cytoplasmic particles in amounts (about 100 mg of protein) and in a state of purity (95%) that make them suitable for detailed biochemical studies. The results obtained so far on these preparations have made more conclusive and precise previous estimates of the biochemical and morphological properties of the three groups of cytoplasmic particles. In addition, peroxisomes were found to contain essentially all the L-alpha-hydroxy acid oxidase of the liver, as well as a small, but significant fraction of its NADP-linked isocitrate dehydrogenase activity. Another small fraction of the latter enzyme is present in the mitochondria, the remainder being associated with the cell sap. The mitochondrial localization of the metabolically active cytoplasmic DNA could be verified. The relative content of the fractions in mitochondria, whole peroxisomes, peroxisome cores, lysosomes, and endoplasmic reticulum was estimated independently by direct measurements on electron micrographs, and by linear programming (based on the assumption that the particles are biochemically homogeneous) of the results of enzyme assays. The two types of estimates agreed very well, except for one fraction in which low cytochrome oxidase activity was associated with mitochondrial damage.


Thin-layer chromatography of vitamin D and related sterols.


Simultaneous Graves' disease and Cushing's syndrome with unusually low levels of plasma cortisol.


Endocrine function in thalassemia major.


Enterohepatic metabolism of estriol-3-sulfate-16-glucosiduronate in women.


Bilateral carcinoma of the breast in a patient with Klinefelter's syndrome.


Failure of placental microsomes to aromatize testosterone sulfate.


The development of bovine syndactylism.

The development of bovine syndactylism.


A comparative in vivo and in vitro study of normal peripheral nerve and nerve tumors.


Uptake of peroxidase and other proteins by murine brain tumors.


Apparent nucleoside phosphatase activity in the neurofibrillary tangles of Alzheimer's disease.


Ganglionic actions of alpha,alpha'-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl dibromide (DMAE).


Thermal alteration in receptor activity of the rat fundal strip.


The antiarrhythmic properties of ICI 46037, a quaternary analog of propranolol.


Formation of a "false" adrenergic transmitter in cats pretreated with 4-methyoxy-3,5-dihydroxyphenylalanine and its effects on postganglionic sympathetic transmission.


Angiotensin, cocaine and desipramine: comparison of effects on blood pressure responses to norepinephrine, tyramine and phenylephrine in the pithed rat.


The actions of angiotensin II on canine myocardial and plasma catecholamines.


The herpes simplex virus and the nervous system. Review of the literature.


Hypoglycemia: tolbutamide and leucine tests in insulinoma.


Tissue hormones: angiotensin, bradykinin and the regulation of regional blood flows.


Disturbances of pituitary function in central nervous system disease.


Effects of local anaesthetic on the state of water in frog nerves.


Biological activity of  synthetic 1-39 human corticotropin.


Activation of isolated lysosomes by poliovirus-infected cell extracts.


New enzymatic route for the inactivation of angiotensin.


Trapping of free radicals formed by gamma-irradiation of organic compounds.


RNA synthesis in yeast mitochondria: a derepressible activity.


Rat tissue DPNH-cytochrome c reductase activity in altered thyroid states.


Hemorrhagic diathesis in laboratory rodents.


Postnatal changes in the pituitary-adrenal axis of the rat.


Effect of metals upon the conversion of adenosine triphosphate to adenosine 3',5'monophosphate in lipocytes.


Purification of a horse placental inhibitor to hemagglutination by H-1 or HB viruses.


Plaque formation by rhinoviruses.

Plaque formation by rhinoviruses.


Intensive nursing and lactational performance during extended lactation.


The effect of dimethyl sulfoxide (DMSO) on cellular systems.


Fractionation of an esterase from calf spleen implicated in the detoxification of bacterial endotoxin.


The management of ulcerative colitis.

The management of ulcerative colitis.


The ultracentrifugal patterns and chemical composition of ribosomal RNA from liver and hepatoma.


Topochemistry of hydrolytic enzymes in relation to Golgi apparatus in transplanted spontaneous mammary cancer of C3H mice.


Histochemical studies on the cerebellum of squirrel monkey (Saimiri sciureus).


The virus causes of coughs and colds.

The virus causes of coughs and colds.


Functional analysis of subcortical interactions between thalamic somatosensory relay-nuclei.


The interaction of different phospholipids on the blood clotting mechanism.


Human chorionic gonadotrophin excretion in men and women with invasive trophoblast assayed by an immunological and a biological method.


Hypothalamo-pituitary-adrenal function in hypercorticosteroid states.


Ovarian activities of pyridine nucleotide dependent dehydrogenases in the rat during pregnancy and lactation.


Some aspects of transmission at the nerve-smooth muscle junction in the longitudinal muscle of the guinea pig ileum.


Electron microscopy of bovine papilloma and deer fibroma viruses.


Experimental production of canine tracheobronchitis (kennel cough) with canine herpesvirus isolated from naturally infected dogs.


Charcoal agglutination test for the detection of antibodies to infectious canine hepatitis virus: comparison of charcoal agglutination, complement-fixation, and serum-neutralization tests.


Granular cell myoblastoma of the canine tongue: case reports.


Inhibition of hepatic gluconeogenesis in guinea pig by phenformin.


In vitro effects of phenformin hydrochloride: observations using isolated fat cells.


Oxidation-reduction components of a reduced diphosphopyridine nucleotide dehydrogenase.


Action of spleen phosphodiesterase uponsoluble ribonucleic acid.


Comparison of amino acid polymerization factors isolated from rat liver and rabbit reticulocytes.


Deproteinization of cell extract with silicic acid.


Involvement of transfer ribonucleic acid in early reactions of polyphenylalanine synthesis.


Natural history of herpetic infection.

Natural history of herpetic infection.


Pleomorphic adenoma in the neck of a child.


Induction of thymidine-3H incorporation in multinucleated myotubes by Rous sarcoma virus.


An X-band electron spin resonance spectrometer with a ruby maser preamplifier.


The impairment of glucogenesis by gram negative infection.


Phosphorus depletion in man.

Phosphorus depletion in man.


The oncogenicity of human adenoviruses in hamsters.


Long term maintenance of cell cultures under agar overlay and development of herpes T plaques.


The action of cortisone on the metabolism of the normal, intoxicated, or vitamin B12 protected liver cell.


Virological examination of children with acute exanthematous disease.


Amoebic meningoencephalitis.

Amoebic meningoencephalitis.


Saturated fatty acids in poliovirus host cell interaction. I. Stimulation and inhibition of virion uptake.


Saturated fatty acids in poliovirus host cell interaction. II. Model experimental on stimulation of phagocytosis.


Correlation between renal renin content and number of juxtaglomerular granular cells.


Protective effect of sucrose and mannitol against vasoconstriction induced by angiotensin II in the kidney.


Control of erythritol dehydrogenase in Schizophyllum commune.


Nitrate reduction in Aerobacter aerogenes. I. Isolation and properties of mutant strains blocked in nitrate assimilation and resistant against chlorate.


Variation of ESR signal amplitude with duration of tumor growth.


Electron spin resonance study on the interaction between chemical carcinogens and tissue components. II. Free radicals produced by stirring aromatic hydrocarbons with tissue components such as skin homogenates or proteins.


Studies of etiology of laryngeal papilloma and an autogenous laryngeal papilloma vaccine.


Methods for identifying neuroplasmic components conveyed to muscle cells via the axons.


DNA content of rat ascites hepatoma cells with hyppo- and hyper-diploid number of chromosomes.


Degradation of yeast ribonucleic acid by polynucleotide phosphorylase from Azotobacter agilis (vinelandii). II. Effect of terminal phosphate of ribonucleic acid and effect of ribonucleoside 5'-diphosphate.


Studies on cytochrome oxidase of yeast. I. Purification and enzymatic activity of cytochrome oxidase from saccharomyces oviformis M2.


Electron spin resonance studies of free radicals in gamma-irradiated amino acid crystals: alpha-amino isobutyric acid and L-lysine-HCl-2H2O.


Angiotensinase activity using human crude angiotensin.


The role of mammals as primary and supplementary hosts.


Acid angiotensinase, renin, and acid adenosine triphosphatase in rat kidney lysosomes.


Japanese encephalitis vaccine including a preliminary report on dengue fever and Chikungunya vaccines.


Vector control in Asia.

Vector control in Asia.


Epidemics of mosquito-borne virus diseases in the Pacific area, exclusive of dengue and Chikungunya viruses with emphasis on the past five years.


A phase cinematography study on morphological changes of FL-line cells following the infection of poliovirus.


Studies on the protection test of pertussis vaccine. Immunization period and protectivity. 3. Influence of heat and formation on the vaccine preparation.


Action of hydrogenated ergot alkaloids upon transmission to sweat glands in the cat.


Electron paramagnetic resonance of chlorophyll-water aggregates.


Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability.


The activation of amino acids for biosynthesis of gramicidin S.


Realistic utilization: levels of preparation.


Porcine polioencephalomyelitides.

Porcine polioencephalomyelitides.


The penthouse--a discharge oriented unit.


Factitious genital sclerogranuloma.

Factitious genital sclerogranuloma.


The development of the psychoanalytic concept of depression.


Geriatrics.

Geriatrics.


Topical spray of antibiotics in simulated combat wounds. IV. Dose factor.


The mechanism of glucose 6-phosphate-D-myo-inositol 1-phosphate cyclase of rat testis. The involvement of hydrogen atoms. Comparison of the initial (3)H/(14)C ratios in specifically labelled d-glucose 6-phosphates with the final ratios in myo-inositol produced by glucose 6-phosphate-d-myo-inositol 1-phosphate cyclase from rat testis showed that, during the conversion, the hydrogen atoms at C-1 and C-3 were fully retained, one hydrogen atom was lost from C-6, and that at C-5 was apparently retained to the extent of 80-90%. The loss of (3)H could not be stimulated by addition of unlabelled NADH, and when unlabelled substrate was used (3)H from [(3)H]NADH and [(3)H]water was not incorporated. Treatment of the enzyme with charcoal abolished the activity, and this was restored to 25-50% of the original activity by NAD(+). The charcoal-treated enzyme again apparently gave 85% retention of hydrogen with [5-(3)H]glucose 6-phosphate as substrate in the presence of NAD(+) alone, but the retention was decreased to 65% with excess of NADH. The results are interpreted as indicating that the cyclization proceeds by an aldol condensation in which C-5 is oxidized by NAD(+) in a tightly-bound ternary complex, and that the apparent loss of (3)H when untreated enzyme is used is due to an isotope effect. It is suggested that after treatment with charcoal some exchange of NADH with an external pool may take place.


Specific binding of [14C] piericidin A in the reduced nicotinamide--adenine dinucleotide dehydrogenase segment of the mitochondrial respiratory chain.


A parent speaks.

A parent speaks.


A behavior rating scale for assessing nursing care requirements of psychiatric patients.


Psychiatric drugs and trends. The alarming comeback of gonorrhea.


The distribution of monoamine oxidase and alpha-glycerophosphate dehydrogenase in pig brain. Activities of the enzymes monoamine oxidase (EC 1.4.3.4), alpha-glycerophosphate dehydrogenase (EC 1.1.99.5) and cytochrome oxidase (EC 1.9.3.1) were determined in homogenates and in the mitochondrial fraction prepared from individual regions of pig brain. The variation in the activity of alpha-glycerophosphate dehydrogenase paralleled that of cytochrome oxidase, but this was not the case with monoamine oxidase. The differences in the activities of the enzymes among homogenates of the various regions of the brain persisted in mitochondria prepared from these homogenates. The purification of these three enzymes paralleled each other when mitochondria were prepared, suggesting that the three enzymes are bound to the same particles.


Activity of nicotinamide-adenine dinucleotide pyrophosphorylase in liver nuclei. Effects of partial hepatectomy, hepatotoxins and dietary changes. 1. The activity of NAD pyrophosphorylase is lower in nuclei isolated from regenerating rat liver than in normal nuclei, and this is due to leakage of the enzyme from the nuclei during the isolation. 2. The NAD pyrophosphorylase activity is lower in liver nuclei from newborn rats, and from rats on a protein-free diet, but no leakage occurs in these cases. 3. Poisoning with alpha-amanitin brings about a transient enhancement of NAD pyrophosphorylase activity in mouse liver nuclei. 4. No changes of enzyme activity were observed after 72hr. starvation, administration of actinomycin D or infection with MHV3 virus.


The organization of psychiatric services in the USSR and the role of the nurse.


Relations between conformations and activities of lipoamide dehydrogenase. 3. Protein association-dissociation and the influence on catalytic properties.


Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro. 1. A method was devised for the isolation of islets of Langerhans from rabbit pancreas by collagenase digestion in order to study the influx and efflux of K(+) in islets during insulin secretion. 2. Glucose-induced insulin release was accompanied by an increased rate of uptake of (42)K(+) by the islets of Langerhans, though this was not the case for secretion in response to tolbutamide. Ouabain significantly inhibited the uptake of (42)K(+) by islet tissue. 3. No significant increase in the rate of efflux of (42)K(+) was demonstrated during active insulin secretion. 4. Slices of rabbit pancreas were incubated in media of different K(+) content, and rates of insulin release were determined. Alteration of the K(+) concentration of the medium between 3 and 8mm had no effect on the rate of insulin release by pancreas slices. However, decrease of the K(+) concentration to 1mm resulted in inhibition of secretion in response to both glucose and to tolbutamide. Conversely, an increase in K(+) concentration increased rates of insulin release in response to both these stimuli. 5. It is concluded that, though unphysiological concentrations of K(+) may influence the secretion of insulin, fluxes of K(+) in the islets do not appear to be important in the initiation of insulin secretion.


Kinetic isotope effects in enzymatic oxidations of D-[1-H]glucose and D-[1-2-H]glucose.


The sterochemistry of hydrogen transfer catalysed by D(-)-3-hydroxybutyrate dehydrogenase.


The localisation of acid phosphatase activity changes in lysosomes in the adrenal zona fasciculata of intact and hypophysectomized rats following ACTH administration.


The specific cytochemical demonstration in the electron microscope of periodate-reactive mucosubstances and polysaccharides containing vic-glycol groups.


Antibodies against Enteroviruses in different age groups.


Electrolyte alterations in vascular smooth muscle and hypotensive activity of a new chalcone derivative.


New developments in antibiotic interference thresholds of microbial assays.


A virilizing adrenal tumor with borderline elevation of urinary 17-ketosteroids.