Role of the brain stem in pathogenesis of hypertension.


Vascular reactivity in experimental hypertension.


On the humoral factors in arterial hypertension.


Significance of angiotensinase on renin-angiotensin system.


NAD biosynthesis as an early part of androgen action.


Tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors.


Prevention of SV40 virus oncogenesis in hamsters. I. Tumor resistance induced by human cells transformed by SV40.


Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.


Intracellular mitochondrial diversity in various strains of Saccgarintces cerevisiae.


Studies of adenovirus-SV40 hybrid viruses. 3. Transfer of SV40 gene between adenovirus types.


The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3.


Nocturnal nephrogenic diabetes insipidus.


Polysaccharides, nucleic acids, and protein of wheat stem rust (Puccinia graminis tritici) urediospores.


Biosynthesis of lipids in plants. I. Incorporation of orthophosphate-32P and glycerophosphate-32P into phosphatides of Chlorella vulgaris during photosynthesis.


Metabolism in vitro of tritiated adrenocorticotrophic hormone.


Effect of nutritional state on hormonal regulation of liver enzymes.


Estimation and quantification of myocardial contractility in the closed-chest dog.


The effect of pH on the release of free fatty acids and glycerol from adipose tissue stimulated with adrenalin, adrenocorticotropin and glucagon.


On the surface localization of enzymes in E. coli.


Enzymic activity of a cytochrome A preparation free of cytochrome a3 from cardiac muscle.


Asymmetric dehydration of galactarate by bacterial galactarate dehydratase.


Proteolipids. 3. Protection of lipid-cytochrome c by an antioxidant fraction from beef heart.


Response to metyrapone in children with rheumatic diseases.


Studies on the feed-back regulation of cholesterol synthesis.


Some aspects of the development, biology and biochemistry of rat hepatomas of different growth rate.


Correlation of enzyme activities and metabolic pathways with growth rate of hepatomas.


Synthesis of purines and nucleic acids and catabolism of purines by rat liver and hepatomas.


Studies on thymidylate phosphatase, thymidine kinase and thymidylate kinase activities in some transplantable rat hepatomas.


Some factors regulating the rate of gluconeogenesis in animal tissues.


Histologic changes in the adrenal cortex of hypophysectomized-gonadectomized rats treated with gonadotrophins or adrenocorticotrophin.


Cytomegalic inclusion disease.

Cytomegalic inclusion disease.


Angiotensin and its response in different diseases.


Studies on the Straub diaphorase. I. Isolation of multiple forms.


Studies on the Straub diaphorase. II. Properties of an antibody to the Straub diaphorase.


Increased specific activity and formation of an inhibitor from the LDH-5 isozyme of lactate dehydrogenase.


Biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. 3. Transfer of L-rhamnose and D-galactose.


Synthesis of trinucleoside diphosphates with polynucleotide phosphorylase.


Synthesis of DL-1,2-dihydroxyhexadecane, DL-erythro-1,2,3,-trihydroxyhexadecane, and DL-1,2-dihydroxy[1,3,4-3H]hexadecane. Metabolism of [1,2-3H]palmitaldehyde and DL-1,2-dihydroxy[1,3,4-3H]hexadecane.


Terpene metabolism in the rat testis. II. Metabolism of mevalonic acid by cell-free preparations.


Histochemical studies on carbohydrate metabolism of the mesencephalic nucleus of the trigeminal nerve in the rat.


Transmission of Mycobacterium leprae to animals. Nerve involvement in the ears of hamsters.


Nodular panniculitis and peripheral neuropathy following sudden withdrawal of corticosteroids. (Poststeroid nodular panniculitis).


Cirrhosis and hepatoma in alcoholics.

Cirrhosis and hepatoma in alcoholics.


The interaction of external and internal controls on enzyme levels and hepatoma.


Histochemical study on the Paneth cell in the rat.


Alveolar carcinoma of the lung, encephalitis due to herpes simplex.


Pressor hypertension.

Pressor hypertension.


On the efficiency of oxidative phosphorylation in yeast mitochondria.


The cytopathic effects of tumor viruses in human diploid cells. Similarity with lesions of irradiated cells.


Peripheral neuritis after long-term isoniazid.


Angiotensin response in various liver diseases with special reference to liver function tests.


Neurovascular compression syndrome of the upper extremity.


Mucoepidermoid tumors of the bronchus.

Mucoepidermoid tumors of the bronchus.


Autoradiographic localization of the acetylcholine-stimulated synthesis of phosphatidylinositol in the superior cervical ganglion.


Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo.


Induction of cellular DNA synthesis by polyoma virus.


Analysis of DNA preparations by a variation of the cysteine-sulfuric acid test.


A spectrophotometric method for the determination of nucleoside triphosphates (pyrophosphorolysis of nucleoside diphosphate sugars).


The leukocyte response during viral respiratory illness in man.


Recovery of cytomegalovirus from adults with neoplastic disease.


A rapid test for adrenocortical insufficiency.


Cryofibrinogenemia, multiple dysproteinemias, and hypervolemia in a patient with a primary hepatoma.


Nerve motor fiber characteristics in chronic ischemia.


A study on the host-tumor relationship, with special reference to protein metabolism.


Electron microscopy of transplantable lymphocytic leukemia and reticulum cell sarcoma in C3Hf mivece.


Characteristics of an inbred substrain (C3H/HeNSa) of C3H mouse, with reference to the mammary cancer incidence and metastasis.


Inhibition of tumor growth by new sulfonic acid esters of aminoglycols.


Patterns of urinary excretion of steroids in Cushing's syndrome.


Remission in Cushing's syndrome with o,p'-DDD.


Studies in a patient with an ectopic adrenocortical tumor.


Urinary steroid metabolites in children. I. Individual 17-ketosteroids in children with normal sexual development.


Plasma testosterone and urinary 17-ketosteroids in women with hirsutism and polycystic ovaries.


An improved technic for vascular isolation of the liver: experimental study and case reports.


Effect of aurovertin on energy-linked processes related to oxidative phosphorylation.


St. Francis' busy bees.

St. Francis' busy bees.


Work sampling--a nursing station study.

Work sampling--a nursing station study.


Carcinomatous neuromyopathies. A review of neurological syndromes associated with malignant neoplasms and unrelated to metastases.


Corticoid concentration of plasma in shock and after ACTH administration.


Congenital omphalocele in association with cytomegalic inclusion body disease in a newborn child.


Effect of magnesium on posterior pituitary hormone action on vascular smooth muscle.


Chronic lesions and ACTH: effects of thyroid hormones and electrical stimulation.


Rhythmic activity in smooth muscle from small subcutaneous arteries.


An automated turbidimetric system for antibiotic assay.


The application of automated procedures for studying enzyme synthesis in Escherichia coli.


The correlation of physical and chemical parameters in pharmacodynamics.


The use of the autoanalyzer for the automatic titration of antigenic preparations by means of complement-fixation.


The effect of sulphur compounds on free radical reactions and formation in irradiated dry proteins.


Adrenocorticotropins. XXXV. The optical rotatory dispersion of sheep adrenocorticotropic hormone in acidic and basic solutions.


Early effects of ACTH on adrenal protein synthesis.


Observations on phosphorylase activity distribution in the adrenal cortex: effect of ACTH.


Surgery of the brachial plexus. Report of a case.


Herpes simplex meningo-encephalitis.

Herpes simplex meningo-encephalitis.


Treatment of acquired neuropathies.

Treatment of acquired neuropathies.


Biological properties of rat cells transformed in vitro by Rous sarcoma virus.


Syringoma. Histochemical and electron microscopic studies.


Ovarian lipoid and theca cell tumors; their origins and interrelations.


Attempts to isolate virus from x-ray induced leukemias in the mouse.


Viral particles in human breast cancer.

Viral particles in human breast cancer.


Xanthomatous neuropathy in primary biliary cirrhosis.


Effects of severe protein-calorie deficiency on the endocrine control of carbohydrate metabolism.


Glioblastoma multiforme involving the posterior fossa. Case report and review of literature.


Granular-cell myoblastoma of the pituitary.


Renin and angiotensin. A survey of some aspects.


Ocular manifestations of hemoglobin S-C disease. Three patients with hemoglobin S-C disease, all with ocular lesions, were studied and contrasted with four other patients who had predominantly either hemoglobin S or C but no ocular lesions. Attention is drawn to the diagnostic value of hemoglobin electrophoresis in such cases. With this technique a diagnosis of hemoglobin S-C disease was made in a patient previously thought to the "Eales' disease"; one sister was found to have asymptomatic hemoglobin S-C disease and unsuspected early ocular lesions. The number of persons in Canada with hemoglobinopathies is increasing. Awareness of an association between abnormal hemoglobins and ocular disease may lead to the recognition of an unsuspected blood disorder or of an unsuspected retinopathy.


An analysis of the biphasic response in Rauscher virus disease.


Prevention of virus-induced mammary tumors by an orally active pancreas factor.


Pathogenicity of Rous virus for adult rats.


Immunohistochemical characteristics of insoluble mouse liver cell antigens.


Search for a pressor substance in toxemia of pregnancy.


Kinetic studies on the thermal degradation of purified poliovirus.


Impetigo herpetiformis in two successive pregnancies.


A case of carcinoma of an axillary apocrine gland.


Electron spin resonance in medical research.


Neurological complications of dialysis, transplantation, and other forms of treatment in chronic uremia.


Effect of corticotropin (ACTH) on experimental seizures. Adrenal independence and relation to intracellular brain sodium.


Factors controlling renin in man.

Factors controlling renin in man.


Asbestos-related disease.

Asbestos-related disease.


The myocardial effects of acute and chronic usage of ethanol in man.


Observations on periodic acid Schiff reaction of primitive blood cells in 86 cases of acute leukemia.


Examination and diganosis in patients with head injury.


Effect of sodium ortho- and pyrophosphate on supragingival calculus.


The effects of topical application of phosphate and fluoride solutions on caries incidence and molar surface solubility in Osborne-Mendel rats.


The natural history of mousepox.

The natural history of mousepox.


Mouse hepatitis, reo-3, and the Theiler viruses.


Respiratory virus infections of mice.

Respiratory virus infections of mice.


Monilial septicaemia in acute leukaemia. Successful treatment in a case complicated by acute uric acid nephropathy.


Partial hepatectomy for primary hepatoma.


Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. II. Lesions of the pancreas, parotid and lacrimal glands.


Nonparticipation of hydrogen peroxide in the cytochrome oxidase reaction.


Serum protein binding of vitamin D3.

Serum protein binding of vitamin D3.


Fructose diphosphatase from rabbit liver. IV. Sulfhydryl groups and their relation to the catalytic activity.


An unusual case of synovial sarcoma.

An unusual case of synovial sarcoma.


The subcellular distribution of enzymes in type II glycogenosis and the occurrence of an oligo-alpha-1,4-glucan glucohydrolase in human tissues.


Studies on the NAD-specific isocitrate dehydrogenase from baker's yeast.


The enzymatic isolation  and fluoride catalysed racemisation of optically active Sarin.


Effect of barbiturates on the non-enzymatic oxidation of reduced nicotinamide adenine dinucleotide catalyzed by flavins.


Measurement of the equilibrium constant of the reaction between cytochrome c and cytochrome a.


Prolongation of lifespan in the old rat by adrenal and neurohypophyseal hormones.


The influence of hormone changes during pregnancy on the velocity of collagen aging.


Some characteristics of the virus responsible for osteopetrosis in chickens.


A cytopathic virus causing a transmissible gastroenteritis in swine. II. Biological and serological studies.


Haemagglutination in the typing of enteroviruses.


The excretion of type 1 poliovirus after challenge following primary immunization with quadruple, Salk and Sabin vaccines.


An enzyme histochemical and electron microscopical study of the light organ of the glow-worm, Lampyris noctiluca.


Some observations upon the histology of the oral mucosa of the albino mouse.


Effects of synthetic angiotensin II on catecholamine levels and biological activity.


Conversion of estradiol-17-beta by sperm preparations of sea urchins and oysters.


In vitro corticosteroidogenesis by the duck (Anas platyrhynchos) adrenal.


Clostridial septicemia with intravascular hemolysis; a case report.


Islet-cell adenomas of the pancreas producing hyperinsulinism.


Lipid composition of heart muscle homogenate.


Phospholipid composition of chick brain during development.


Role of dactinomycin in the improved survival of children with Wilms' tumor.


Respiratory arrest associated with intravenous administration of polymyxin B sulfate.


Granular cell myoblastoma of the bronchus. Case report with a six-year follow-up.


Effect of hypophysectomy or treatment with thyroxine or testosterone on secretory responses and respiratory enzymes of the submaxillary gland of the rat.


Evidence for a new bacterial collagenolytic enzyme.


Long-lived radiation-induced electron spin resonances in an aqueous biological system.


Bound pyridine nucleotide of malic-lactic transhydrogenase.


Application of the periodate method for the analysis of nucleotide sequence to tobacco mosaic virus RNA.


The site of diphosphoinositide synthesis in rat liver.


On the heterogeneity of the deoxyribonucleic acid associated with crystalline yeast cytochrome b2.


Studies of nucleotide sequences in tobacco mosaic virus. II. The action of spleen phosphodiesterase.


Clinical observations on the value of adrenocortical therapy in the Guillain-Barré symdrome.


A partial purification and characterization of a phosphoanhydride hydrolase (phosphoprotein phosphatase) from the frog egg.


The effect of palmityl coenzyme A on glucose 6-phosphate dehydrogenase and other enzymes.


A serological survey on natural infection of polyoma virus in experimental animals on Taiwan.


Mixed infection of poxviruses in L cells. I. Occurrence of the rescue of dermovaccinia virus by neurovaccinia virus in L cells.


Lymphangiography: direct and indirect utilizing an iodinated emulsion.


Histochemical localization of esterases, phosphatases and tetrazolium reductases in the motor neurones of the spinal cord of the rat and the effect of nerve division.


Hidradenoma papilliferum.

Hidradenoma papilliferum.


Biosynthesis of corticoids in guinea pig adrenal slices. [1-14-C]acetate incorporation into adrenal steroids and sterols.


Stabilities of metal complexes of phospholipids: Ca(II), Mg(II), and Ni(II) complexes of phosphatidylserine and triphosphoinositide.


Liver response tests. IV. Application to short-term feeding studies with butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA).


Liver response tests. VI. Application to a comparative study of food antioxidants and hepatotoxic agents.


A clinicopathologic study on the peripheral nervous system of the aged. Sciatic nerve and autonomic nervous system.


Mechanism of cell transformation by polyoma virus.


Ion exchange between alkali metal cations and sodium aluminosilicate gel at 276 degrees, 298 degrees, and 319 degrees K.


An experimental study on the effect of reticuloendothelial activity on metastasis and recurrence of tumor.


Disruption of mitochondria and solubilization of cytochrome oxidase by a synthetic zeolite.


Treatment of hypsarrhythmia and infantile spasms with a librium analogue.


Observations on production, assay and purification of chick embryo interferon.


Chromosomal damage of human cells induced by Sendai virus.


The presence of carotid body like structure between the right subclavian and common carotid arteries.


Plasma angiotensinase activity in liver disease.


Further studies in decompression for inferior alveolar nerve injury.


A patient with semi-membranous cyst in leprosy simulating nerve abscess.


Comparative assay of foot-and-mouth disease virus in cattle, mice, and cell cultures.


Cross-protection product in an attempt of quantitative antigenic differentiation of two foot-and-mouth disease virus strains type O in cattle.


Typing of the foot-and-mouth disease virus.


A revised list of subtype reference strains of the virus of foot-and-mouth disease held at the World Reference Laboratory, Pirbright, England.


Sensitivity of cell cultures, cattle, mice, and guinea-pigs for detection of nineteen foot-and-mouth disease viruses.


Prognosis in carcinoma of the stomach in relation to the microscopic type.


Titration and neutralization of poliovirus in micro tissue culture under increased carbon dioxide. Modification of the micro tissue culture technique, including incubation under increased CO(2), resulted in prolongation of the viability of the cells. As a consequence, satisfactory titrations of poliovirus and of poliovirus antiserum have been achieved by the micro method. The technique offers a number of advantages over conventional methods.


Activity of foot-and-mouth disease virus antiserum after treatment with beta-propiolactone to inactivate a contaminating virus.


Modification of the procedure to determine the sensitivity of viruses to chloroform.


Assay of variola virus by the fluorescent cell-counting technique. A quantitative assay for infective variola virus particles was developed which is based on the enumeration of cells containing fluorescent viral antigen after infection of McCoy cell monolayers. The direct fluorescent-antibody technique was employed to stain cells. The efficiency of virus adsorption was markedly enhanced by centrifugation of virus inoculum onto McCoy cell monolayers at 500 x g for 15 min. By this procedure, a proportionality was obtained between the number of fluorescent cells and volume of inoculum. Observations on the sequential development of viral antigen within cells and counts of fluorescent cells showed that the optimal time for enumerating fluorescent cells was after an incubation period of 16 to 20 hr. A linear function existed between virus concentration and cell-infecting units. Fluorescent cells were distributed randomly in infected cover slip cell monolayers. The assay was demonstrated to be highly sensitive, precise, and reproducible.


Level and specificity of antibodies evoked by crude and purified antigens of poliovirus I and echovirus 7. Preparations of poliovirus I and echovirus 7, purified by density gradient centrifugation, liquid-phase partition, and anion exchange (diethylaminoethyl) chromatography, have been shown to evoke high antibody levels of substantial specificity in the complement-fixation assay. Certain practical aspects of the three purification methods are discussed. These results argue for the use of purified viral antigens, particularly in view of the simplicity of the purification methods now available.


Continuous cultivation of virus in cell suspensions by use of the lysostat. Theoretical considerations illustrate the feasibility and characteristics of continuous virus cultivation in cell suspensions Physical dimensions of the virus fermentor (lysostat) in relation to optimal yields can be predetermined. Poliovirus type 1 was grown on Hela S-3-1 (Saltzman) cells in a single-stage, percolator-type lysostat, with a yield of 421 TCID(50) per cell. Adenovirus type 14 was grown on KB (Eagle) cells in a two-stage lysostat with a yield of 116 TCID(50) per cell.


Sensitivity of agar overlay method for the recognition of enteroviruses. COMPARISON OF THE AGAR OVERLAY TECHNIQUE WITH THE FLUID CULTURE TECHNIQUE FOR ISOLATION AND IDENTIFICATION OF ENTEROVIRUSES SHOWED THE FORMER TO BE USEFUL: (i) for isolation of enterovirus when the number of virus particles was too small to produce detectable cytopathic effect (CPE) in fluid cultures, (ii) for isolation of echovirus 22 which did not produce detectable CPE in fluid cultures, (iii) as an aid to rapid differentiation of enteroviruses, and (iv) for differentiation of viruses in mixed infections. Nonpolio enterovirus isolation experience in the New Haven area over a 4-year period is presented. It was concluded that the agar overlay technique is both useful and relatively simple for routine examination of clinical specimens in a diagnostic laboratory.


The pathogenesis of experimental infections with encephalomyocarditis (EMC) virus.


Herpes simplex virus and paralysis of animals.


Induced upper respiratory infection in the vervet monkey: a model of acute viral respiratory disease in man.


Electron spin resonance of free radicals electrochemically generated from polynitroalkanes.


Acute transverse myelitis as a complication of glandular fever.


Phosphorylase and glucose-6-phosphatase in the African lungfish.


Some applications of paper and vapour-phase chromatography to polysaccharides. Model studies on a synthetic D-mannan.


Studies on the mechanism of the vasoconstrictor effect of angiotensin II in man.


Effects of isotopic substitution on electron spin resonance signals in photosynthetic organisms.


The effect of epinephrine upon subcommissural organ secretion in the rat.


Trypsin in resorption of hyphemas.

Trypsin in resorption of hyphemas.


Anaphylactic antibody in the young rat.

Anaphylactic antibody in the young rat.


The effect of various hormones on the serum level of anaphylactic antibody in the rat.


Studies on menadione reductase of bakers' yeast. 3. The identity of menadione reductase with lipoamide dehydrogenase.


Glomus tumour of the knee. Report of a case.


Crystal synovitis.

Crystal synovitis.


Status report on virus isolation in infectious hepatitis (I.H.).


Active immunization against infection caused by B virus. (Herpes-virus simiae). II. Dynamics of neutralizing antibodies in rabbits immunized with inactivated vaccine and challenged with live virus. Attempts to obtain highly active antiserum against B virus.


Prevention of corrosive stricture of the oesophagus in the rat.


Effects of estrogenic hormones on the mammary tissue of agent-free and agent-bearing male mice.


Growth characteristics and virology of regressing Rous sarcomas.


Genetic studies on the etiology and morphology of mammary tumors in mice.


Hyperplastic lesions of mouse mammary glands after treatment with 3-methylcholanthrene.


Genetic influence of the Rs locus on susceptibility to avian tumor viruses. II. Rous sarcoma virus antibody production after strain RPL12 virus inoculation.


Adenovirus and intussusception.

Adenovirus and intussusception.


Two cases of Sheehan's syndrome.

Two cases of Sheehan's syndrome.


Bronchial adenomata. A clinical résumé.

Bronchial adenomata. A clinical résumé.


Cytochrome c oxidase and phosphatides. I. Spectral changes associated with changes in phosphatide profile.


Intracellular localization and properties of trimethylamine-N-oxide reductase in Vibrio parahaemolyticus.


Lipoyl dehydrogenase from Saccharomyces cerevisiae. I. Purification and some properties.


The effect of increased pH on the spectral properties of fungal laccase.


Phosphate transfer from adenosine diphosphate phosphoglycerate and 2,3-diphosphoglycerate.


The relation between structure and function in electron-transport systems. I. Sequential release of nicotinamide-adenine dinucleotide dehydrogenase activity by a series of physical treatments.


Lactate dehydrogenase activity in the preimplanted mouse embryo.


Evidence for the role of bound water and partial desiccation in carcinogenesis.


Direct x-ray inactivation of the viruses of Teschen and Talfan diseases, foot-and-mouth disease and vesicular stomatitis.


Rapid biochemical presumptive test for gonorrheal urethritis in the male.


Formalinized red cells in diagnostic virology.


The biochemistry of heme-iron.

The biochemistry of heme-iron.


The biochemistry of copper.

The biochemistry of copper.


The biological function of molybdenum.

The biological function of molybdenum.


Clinical use of diazoxide and mechanism for its hyperglycemic effects.


A poliovirus-induced double-stranded RNA: double-helical properties and labelling kinetics.


Studies on cytochrome a. XIV. The sulfhydryl groups in cytochrome a.


Kinetic studies on the action of collagenase.


Evaluation of an antineoplastic agent. Dactinomycin (Cosmegen).


Restless legs syndrome in uremic neuropathy.


Aphasia due to a right hemisphere tumor in a right-handed man.


Long-term survival following conservative surgery for bilateral arrhenoblastoma. Report of a case.


Direct lymphangioadenography of the uterine cervix.


The electron-histochemical demonstration of phosphoglyceride.


Fluorescent antibody studies of virus-induced tumors.


The localization of succinic dehydrogenase, cytochrome oxidase and adenosine triphosphatase in ciliated respiratory epithelium.


Clear-cell adenocarcinoma in an endometrioid ovarian cyst.


The preferential demonstration of deoxyribonucleic acid by a periodic acid-silver diamine method for light and electron microscopy.


The effect of corticotropin hormone on lipolytic activity in the adrenal glands of the rat.


Virus: mixed infection with herpes simplex and simian virus 40. Mixed infection, the infection of a single cell by two distinguishable viruses, has been demonstrated by electron microscopy in cultures of African green monkey kidney cells after inoculation with simian virus 40 and herpes simplex. Mixed infection occurs rarely when the two viruses are inoculated simultaneously, but if herpes is inoculated 24 hours after SV40 both viruses are found in the same nucleus in about 5 percent of intact cells.


Increased activities of glycogenolytic enzymes in liver after splanchnic-nerve stimulation. Electrical stimulation of the splanchnic nerve of rabbits caused a marked increase, within 30 seconds after the onset of stimulation, in liver-glycogen phosphorylase and glucose-6-phosphatase activities. The increased activity of liver phosphorylase after splanchnic-nerve stimulation was likewise observed in adrenalectomized and pancreatectomized rabbits. Glycogen content of the liver decreased only slightly after 5-minute stimulation.


The action of physalaemin on the systemic arterial blood pressure of some experimental animals.


Complement-fixing antigens in hamster tumors induced by the Bryan strain of Rous sarcoma virus. Hamster tumors transplanted subcutaneously from primary intracranial tumors which developed after inoculation of the Bryan strain of Rous sarcoma virus, contained virusspecific tumor antigens indistinguishable from those induced by the Schmidt-Ruppin strain.


Enlarged chromosome No. 1 in a patient with primary amenorrhoea.


Carcinoma and the calcified gall bladder.


Ferredoxin linked DPN reduction by the photosynthetic bacteria Chromatium and Chlorobium.


Viral respiratory diseases in Nigeria: a serological survey. I. Complement fixing antibody levels of influenza A, B and C and para-influenza 1.


Triplet ESR in L-tyrosine.

Triplet ESR in L-tyrosine.


Osteolytic sterol in human breast cancer. Eleven of twelve human breast cancers contained a lipid which increased urinary (45)Ca and (40)Ca excretion of (45)Ca-labeled, parathyroidectomized rats receiving a low Ca diet. The lipid has mobility on thin-layer chromatography and gas-liquid chromatography close to, but not identical with, that of 7-dehydrocholesterol. Authentic 7-dehydrocholesterol has osteolytic activity similar to that of the extracted sterol. Fluorescence and Lieberman-Burchard reactions of the extracted sterol are similar to those of 7-dehydrocholesterol. The lipid was found by thin-layer chromatography in the extracts which had osteolytic activity. Neither the lipid nor osteolytic activity was found in extracts of tissue from two normal human breasts.


Fumarate reductase in the control of heme biosynthesis. A drug-induced stimulation of heme biosynthesis in mouse liver was accompanied by altered fumarate metabolism. In liver homogenate, fumarate 1,4-C(14) was incorporated, via succinate and succinyl coenzyme A, into heme at an accelerated rate. This pathway of fumarate utilization was inhibited by acetoacetate but not by beta-hydroxybutyrate. Fumarate reduction to succinate required reduced nicotinamide adenine dinucleotide. The enzyme fumarate reductase is suggested as a link between terminal oxidation and cellular control of the heme biosynthetic pathway.


Interferon: lack of detectable uptake by cells. No interferon, or at most a small fraction of that applied, is taken up by cells during the period of induction of antiviral activity. The lack of detectable adsorption was not influenced either by the concentration of interferon or the volume. The results were similar in both chicken and mouse systems.


Oxidative phosphorylation in extracts of thiobacillus X.


Incorporation of myoinositol-3H into the phosphoinositides of cat brain in vivo.


Substrate specificity and inhibition studies on potato apyrase.


Radioprotection of the rat thyroid by different antithyroid compounds.


Survival after high-tension electrical burns complicated by acute tubular necrosis.


A generalized theory of particulate electron conduction enzymes applied to cytochrome oxidase. A theory of coupled electron and/or ion transport applied to pyruvate carboxylase.


Release of enzymes from rat liver mitochondria by freezing.


Nucleic acid of murine encephalomyelitis virus. Physical and chemical studies.


Spread of pulmonary coccidioidomycosis associated with steroid therapy. Report of a case with a lupus-like reaction to antituberculosis chemotherapy.


A study of human papilloma virus DNA.

A study of human papilloma virus DNA.


Apparent potentiation of neuromuscular block by antibiotics.


New Jersey "Chicken trial": verdict for science.


Biosynthesis and composition of histones in Novikoff hepatoma nuclei and nucleoli. Histones were prepared from isolated nuclei and nucleoli of the Novikoff ascitic hepatoma at several time points after the injection of L-lysine uniformly labeled with C(14) into tumor-bearing rats. Amino acid analysis and starch-gel electrophoresis failed to reveal any differences between the nuclear and nucleolar histones, although both fractions were more acidic in composition than calf thymus histones. However, the nucleolar histones were a metabolically distinct fraction, and their rate of synthesis was approximately twice that of the total nuclear histones.


Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid. There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.


Further observations on geographic variation in the antigenic character of West Nile and Japanese B viruses.


Clostridium perfringens food poisoning. Report of an outbreak.


The stimulation of pregnenolone synthesis in the large particles from the adrenals of rats administered adrenocorticotropin in vivo.


The diagnosis and treatment of glomus tumor.


Nature of the cyst of Trichinella spiralis.


Clinical and serological response to laboratory-acquired human infection by Indiana type vesicular stomatitis virus (VSV).


The estimation of polynucleotide chain length by a chemical method.


Periodate oxidation of pseudouridine.

Periodate oxidation of pseudouridine.


Studies on the structure of 23-S ribosomal ribonucleic acid from Escherichia coli.


Two cases of localized hypertrophic neurofibrosis.


Factors affecting the amount and composition of the serum seromucoid fraction.


Influence of oxygen and cysteine on the radical state of x-irradiated lyophilized liver.


Milker's nodule virus infections in Dorset and their similarity to orf.


Management of chemodectomas.

Management of chemodectomas.


Aerosol-induced adenoviral illness resembling the naturally occurring illness in military recruits.


Experiences in seeking an ethiodol emulsion for lymphography.


The effect of acute respiratory infection on pulmonary function in military recruits.


Some surface-active agents and their virucidal effect on foot-and-mouth disease virus. Selected cationic and anionic surface-active compounds were tested to determine their virucidal effect on the foot-and-mouth disease virus, type O, strain M11, propagated in primary calf kidney cells. The chemical inactivation of the virus was tested with 0.5, 1.0, 2.0, and 5.0% concentrations of the selected compounds. Virus controls with pH adjusted to cover the expected range of the mixtures of the chemicals and virus were also tested. The absence of virus from the mixtures of chemical and virus after reaction at 28 C for 2 hr was assayed by inoculating suckling mice with the mixtures. One cationic compound, alkyl methyl isoquinilinium chloride, showed considerable antiviral activity due largely to pH effect. The use of the surface-active agents investigated in this study, in the presence of organic material, would not be recommended as virucides.


Effects of animal alimentary passage on the heat resistance of Clostridium perfringens. The resistance to heat, as measured by D values and phantom thermal death time curves, was observed to increase for one of three strains of Clostridium perfringens type A subsequent to animal passage. Animal passage was accomplished by the force-feeding of germ-free mice with bacterial suspensions of the organism, followed by the force-feeding of additional gnotobiotic mice with the contaminated feces. For the one strain in which an increase in heat resistance was noted, the result could not be attributed to mouse feces per se, since the presence of sterile germ-free mouse feces in a suspending medium did not protect C. perfringens spores from elevated temperature destruction.


The identification of cerebroside sulfate as a component of the inositol phosphatide fraction of ox brain.


Preparation of L-beta-ribonucleosides and L-beta-ribonucleotides.


The effect of angiotensin on the 131-I sodium o-iodohippurate renogram.


Further studies on the determination of renin in rat kidney.


Studies on the determination method of urinary homovanillic acid and its clinical application.


Angiotensin II infusion in renal disease with hypertension.


Topical absorption of polypeptides with dimethylsulfoxide.


A central vasomotor action of angiotensin in man.


Hydrocortisone and/or desiccated thyroid in physiologic dosage. 18. Dexamethasone, plasma corticosteroids, and response to ACTH.


Headaches and seizures.

Headaches and seizures.


In vitro transformation of hamster and human cells with the adeno 7-SV 40 hybrid virus.


SV40-adenovirus "hybrid" populations: transfer of SV40 determinants from one type of adenovirus to another.


Generation of free radicals from phenazine methosulfate, streptonigrin, and riboflavin in bacterial suspensions.


Multiplicity and familial incidence of carotid body and glomus jugulare tumors.


Fine structure of the epithelial cells in mixed tumors of the parotid gland.


An endonuclease from silkworm---purification and mode of action.


Oscillatory oxidations of reduced pyridine nucleotide by peroxidase.


Demonstration of a DPNH: alpha-ketoglutarate oxidoreductase activity in embryonic chick liver supernatant fraction.


Glycerol diphosphate disaccharide-pentapeptide: a functional group of the lipid intermediate in cell wall glycopeptide synthesis.


Molecular transitions in an induced enzyme with enhanced fluorescence.


Enhanced fluorescence of 4-epimerase elicited by 5'-uridine nucleotides.


The activity of immuno-conglutinin in in vitro viral infections.


Subcellular fractionation of human liver.


An antiviral substance from Penicillium cyaneo-fulvum Biourge. II. Biological activities against RNA-containing viruses.


Some studies on cellular fractions of the adductor muscle of Pecten maximus.


The isolation and identification of "volutin" granules from Tetrahymena.


Studies on the metabolism of pregnenolone sulfate.


Evidence for the presence of glucuronides of cortisone and cortisol in human urine.


Effects of a bacterial pyrogen on the pituitary-adrenal axis at various times in the 24 hours.


One-hour intravenous ACTH test.

One-hour intravenous ACTH test.


Complement-fixation tests with cell lines derived from Burkitt's lymphoma and acute leukemias. Armstrong, Donald (Children's Hospital of Philadelphia, Philadelphia, Pa.), Gertrude Henle, and Werner Henle. Complement-fixation tests with cell lines derived from Burkitt's lymphoma and acute leukemias. J. Bacteriol. 91:1257-1262. 1966.-Cells of various lines isolated from Burkitt's lymphomas and acute leukemias and disintegrated by freezing and thawing or sonic treatment were found to react in complement-fixation tests with a considerable proportion of human sera. At least 10(7) cells per milliliter were required for antigenic activity. All but one of 13 sera from Burkitt lymphoma patients were positive, with titers ranging from 1:8 to 1:320. About 20% of sera from American children and 60% of sera from adults, regardless of diagnosis, showed titers in a similar range. Sera giving positive tests with one of the neoplastic white cell antigens usually reacted also with many if not all of the others, but rarely with antigens derived from normal peripheral leukocyte cultures and not at all with HeLa or other human nonleukocytic cells. Various observations indicate that the complement-fixation test measures mainly antigens which are different from those detected by immunofluorescence. The nature of the reactions described remains obscure.


Effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid. Gordon, Irving (University of Southern California, Los Angeles), Sara S. Chenault, Douglas Stevenson, and Jean D. Acton. Effect of interferon on polymerization of single-stranded and double-stranded mengovirus ribonucleic acid. J. Bacteriol. 91:1230-1238. 1966.-The effect of interferon on actinomycin-resistant mengovirus ribonucleic acid (RNA) replication in L cells was investigated to determine whether defective or partially polymerized RNA products were made and whether synthesis of any specific class of virus RNA was prevented. RNA labeled with uridine-C(14) was extracted in hot and cold phenol and analyzed by zonal sucrose density centrifugation. Both single- and double-stranded infectious RNA peaks were identified. Interferon treatment caused almost complete depression of uridine-C(14) incorporation throughout linear sucrose gradients except in the 4S region, and no infectivity was detectable in any fraction. These inhibitory effects are attributable to the action of interferon, because they were reversed when cultures were treated with actinomycin D simultaneously with interferon. The results, with those of other investigators, indicate that the step at which interferon interrupts virus multiplication is between the events immediately after uncoating and the formation of template "minus" strands; under the conditions of our experiments, no partially polymerized virus RNA products were made.


Colorado tick fever virus in cell culture. II. Physical and chemical properties. Trent, Dennis W. (University of Oklahoma School of Medicine, Oklahoma City), and L. Vernon Scott. Colorado tick fever virus in cell culture. II. Physical and chemical properties. J. Bacteriol. 91:1282-1288. 1966.-Heat-inactivation kinetics for Colorado tick fever (CTF) virus grown in L cells indicated that more than one rate constant was involved for inactivation at each exposure temperature. An Arrhenius plot of the data indicated the inactivation rate constants to be dependent on the absolute temperature. The energy of activation, for thermal inactivation of the virus, was 17,289 calories per mole, with the Q(10) being 2.6. The optimal pH range for maintenance of CTF viral infectivity was determined to be 7.5 to 7.8. The infectivity of CTF virus was stable to freezing and thawing in diluents which contained: 50% calf serum, 20% glucose, 20% glycerol, 10% bovine serum albumin, 20 mm glutamine, and 2% gelatin. CTF virus replication was insensitive to inhibition by 5-fluoro-2'-deoxyuridine and 5-bromo-2'-deoxyuridine, whereas herpes simplex virus was markedly inhibited, as reported by others. Actinomycin D inhibited CTF virus replication when cells were pretreated for 24 and 12 hr prior to infection, but not when the inhibitor was added at the time of infection. The nucleic acid of CTF virus appears to be of the ribose type.


Effects of cycloheximide and puromycin on synthesis of simian virus 40 T antigen in green monkey kidney cells. Gilden, R. V. (Wistar Institute, Philadelphia, Pa.), and R. I. Carp. Effects of cycloheximide and puromycin on synthesis of simian virus 40 T antigen in green monkey kidney cells. J. Bacteriol. 91:1295-1297. 1966.-Synthesis of the simian virus 40 (SV40) T antigen in primary African green monkey kidney cells was abolished when cycloheximide was added up to 10 hr postinfection. In contrast, puromycin, another inhibitor of protein synthesis, did not suppress antigen production. The basis of this differential effect was the inability of puromycin to inhibit protein synthesis in the cells used. This was shown by the failure of the drug to depress the incorporation of labeled amino acid into protein and also failure to inhibit poliovirus synthesis. The puromycin preparation used was very effective in inhibiting poliovirus synthesis in HeLa cells. Thus, appearance of the SV40 T antigen is dependent on protein synthesis in infected cells.


Formation of a functional electron transport system during growth of penicillin-induced spheroplasts of Haemophilus parainfluenzae. Wright, Elizabeth A. (University of Kentucky College of Medicine, Lexington), and David C. White. Formation of a functional electron transport system during growth of penicillin-induced spheroplasts of Haemophilus parainfluenzae. J. Bacteriol. 91:1356-1362. 1966.-Penicillin in a lactose medium can be used to cause the formation of spheroplasts in Haemophilus parainfluenzae. The resulting spheroplasts grew under conditions which produced rapid formation of the electron transport system in the normal bacteria. The following elements that are incorporated into a functionally active electron transport system were formed in spheroplasts: formate and l-lactate dehydrogenases, 2-demethyl vitamin K(2), cytochromes b(1) and c(1), and the cytochrome oxidases. The catabolic enzymes aldolase, glyceraldehyde-3-phosphate dehydrogenase, and malic dehydrogenase showed slight increases in activity. These experiments indicated that spheroplasts can form a fully functional electron transport system essentially similar to that formed during normal growth. The various components of the electron transport system were formed at different rates in the growing spheroplasts.


Density gradient centrifugation of bacteria and nonspecific bacteriophage in silica sol.


Inhibition of intestinal ion translocase enzymes by culture filtrates of Vibrio cholerae.


Density of infectious virus and complement-fixing antigens of two rhinovirus strains. Dans, P. E. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), B. R. Forsyth, and R. M. Chanock. Density of infectious virus and complement-fixing antigens of two rhinovirus strains. J. Bacteriol. 91:1605-1611. 1966.-Two rhinovirus serotypes (echovirus 28 and HGP) and poliovirus type 1 were banded by isopycnic centrifugation in cesium chloride. The rhinovirus virions had a density of 1.41 g/ml, whereas that of poliovirus was 1.34. Since a number of other enteroviruses also have a density of 1.34 g/ml in cesium chloride, a basic difference in density may exist between the rhinovirus and enterovirus subgroups of the picornavirus family. Whether this difference reflects differences in ribonucleic acid content or binding of cesium ions remains to be determined. In tests with echovirus 28 two peaks of CF activity were detected: one in association with the virion (1.41 g/ml), and a larger peak of lower density (1.30 g/ml). With echovirus 28 antiserum, a heterotypically reactive complement-fixing (CF) antigen was detected in the HGP virus suspension at a density less than that of the virion (1.30 g/ml). This antigen corresponded in density to the less dense CF antigen of echovirus 28.


Femoral neuropathy in hemophilia.

Femoral neuropathy in hemophilia.


Application of cell fractionation techniques in the study of cells infected with polyoma virus and Newcastle disease virus. Fisher, Harold W. (University of Rhode Island, Kingston), Hidemi Matsumiya, and Masanobu Azuma. Application of cell fractionation techniques in the study of cells infected with polyoma virus and Newcastle disease virus. J. Bacteriol. 91:1645-1651. 1966.-Techniques which permitted rigorous separation of nuclei and cytoplasm were applied to the study of the formation of Newcastle disease virus (NDV) in an established line of Chinese hamster cells and of polyoma virus (PYV) in mouse embryo fibroblasts. The results obtained for hemagglutinin and plaque-forming titers during virus growth were in agreement with those obtained by others, using different techniques. These indicated that NDV matures in the cytoplasm, and PYV in the nucleus, of host cells.


Current concepts in the surgical management of cancer of the pancreas and peripancreatic region.


Artificial heterokaryons of animal cells from different species.


Latent period of vesicular stomatitis virus in chick embryo cells.


Foot and mouth disease virus RNA as an antigenic factor in the complement-fixation reaction applied to the examination of human tumors.


The biology of avian tumor viruses with especial emphasis on forms of virus: cell integration and the neoplastic nature of tumors induced by these agents.


A comparison of the cytoplasmic antigens of fowl virus tumours.


Indirect bacterial hemagglutination, and its application to the study of bacterial antigens and serologic diagnosis.


Malignant cystosarcoma phyllodes with liposarcoma.


Dual respiratory infection with parainfluenza and rhinovirus. The pathogenesis of transmitted infection in volunteers.


Respiratory virus vaccines. I. Respiratory syncytial and parainfluenza virus vaccines.


Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH), and their biological activities.


Quantitation of the radiographically determined age dependence of bone thickness.


Carcinoma of the cervix uteri presenting as Paget's disease of the vulva, with a note on the pathogenesis of the latter.


Gingival metastasis from a hepatoma.

Gingival metastasis from a hepatoma.


Purification and properties of a specific fructose 1,6-diphosphatase from Candida utilis.


Nicotinamide adenine dinucleotide photoreduction with Chromatium and Rhodospirillum rubrum chromatophores.


Mechanism of action of malt beta-glucanases. 8. Structures of products formed during hydrolysis of barley beta-D-glucan by A11-endo-beta-glucanase.


Membrane-bound trehalase from cecropia silkmoth muscle.


Mechanism of action of malt beta-glucanases. 9. The structure of barley beta-D-glucan and the specificity of A11-endo-beta-glucanase.


A colorimetric procedure for the determination of N-acetylated-3-amino hexoses.


Mechanism of carbohydrase action. XII. L-Sorbose as an acceptor substrate in transfer reactions catalyzed by potato D-enzyme.


Lymphography in melanoma. Correlation of radiology with pathology.


A role of catalase in S-methyl group oxidation.


Studies on erythrocyte glycolysis. I. Determination of the glycolytic intermediates in human erythrocytes.


Hexosamine and sialic acid in mitochondria and microsome from rabbit liver.


Studies on cytochrome a. XV. Cytochrome oxidase activity of the Okunuki preparation and its activation by heat, alkali and detergent treatments.


Neural involvement in leprosy treatment with intra-neural injections of prednisolone.


Nerve abscesses in leprosy in Northern India.


Hemoproteins in microsomes in liver of tumor-bearing rats.


Physiotherapy and foot drop corrections.


Thoracic inlet tumors.

Thoracic inlet tumors.


Glioblastoma multiforme of the optic nerve.


DPNH oscillations in glycolyzing cell free extracts from beef heart.


Sterospecificity of hydrolytic enzymes in their reaction with optically active organophosphorus compounds. I. The reaction of cholinesterases and paraoxonase with S-alkyl P-nitrophenyl methylphosphonothiolates.


Effect of angiotensin II on active transport of sodium by toad bladder and skin.


Effect of 1,3-bis-(2-chloroethyl)-1-nitrosourea on Ehrlich ascites tumor cells.


Malignant tumors of salivary gland origin: 37-year review of 184 cases.


Action of angiotension on myocardial and renal catecholamines in the rabbit.


Fate of intravenously injected iodate and periodate.


Proline incorporation into the proline and hydroxyproline of earthworm-cuticle collagen.


Comparison of the biological and serological properties of variola and vaccinia viruses.


The examination of eye movements.

The examination of eye movements.


Effects of sulphur compounds on the free radicals in amino acids and proteins.


The regulation of the synthesis and release of ACTH.


Spontaneous reactions of 1,3-substituted 1,4-dihydropyridines with acids in water at neutrality. I. Kinetic analysis and mechanism of the reactions of dihydronicotinamide--adenine dinucleotide with orthophosphates.


Stereochemical aspects of the substrate specificity of horse liver alcohol dehydrogenase.


Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes.


Syntheses of deoxynucleoside 3'-triphosphates.


Recovery of murine leukemia virus prior to development of leukemia: growth curve and dose response.


Electron microscopic study of the distribution of the mouse leukemia virus (gross) in organs of mice and rats with virus-induced leukemia.


Direct action of a leukemogenic virus on the thymus.


Effect of sex hormones on susceptibility to viral transmission of myeloid leukemia in the mouse.


Comparative biochemistry of hepatomas. VI. Thymidine incorporation into DNA as a measure of hepatoma growth rate.


The reaction of hydrogen atoms with thymine and DNA.


On the mechanism of polyoma virus-induced synthesis of cellular DNA.


Virologic studies of acute respiratory disease in young adults. IV. Virus isolations during four years of surveillance.


The nucleic acid from avian myeloblastosis virus compared with the RNA from the Bryan strain of Rous sarcoma virus.


A spin-labeled hapten.

A spin-labeled hapten.


A lipopolysaccharide inhibitor of a DNA methyl transferase.


Amino acid substitutions resulting from suppression of nonsense mutations. II. Glutamine insertion by the Su-2 gene; tyrosine insertion by the Su-3 gene.


The binding of RNA polymerase to polyoma and papilloma DNA.


Organ distribution of radioiodinated Clostridium perfringens alpha toxin.


Asthma, melancholia, and death. I. Psychoanalytic considerations.


Asthma, melancholia, and death. II. Psychosomatic considerations.


Mixed parotid tumours.

Mixed parotid tumours.


Optokinetic nystagmus and occipital lesions.


Glomus tumor of the stomach: case report.


Measurement of acetaldehydrogenic steroids in urine.


The intracellular distribution of the enzymes catalysing the biosynthesis of glycerides in the intestinal mucosa.


Incorporation of phosphate into diphosphoinositide by subcellular fractions from liver.


Isolation, purification, and characterization of P1,P3-diguanosine 5'-triphosphate from brine shrimp eggs.


Actinomycin inhibition of "soluble" ribonucleic acid synthesis in rat liver.


Symposium on pituitary tumours. 3. Historical aspects of radiotherapy, present treatment technique and results.


Symposium on pituary tumours. 4. Unusual pathological features.


The participation of ribonuclease in the degradation of Escherichia coli ribosomal ribonucleic acid as revealed by oligonucleotides accumulation in the phorphorus-deficient stage.


Photosensitization of xanthine-containing substances: electron spin resonance studies.


Reduction of iodate and periodate by rat tissues in vitro.


Murine leukemia viruses: antigenic studies by quantitative complement fixation. The murine leukemia viruses of Rauscher and Friend, derived from plasnma of infected Balb/c mice, was purified. Their antigenic relationship was studied by quantitative complement-fixation reactions with the virion antigen and homologous antiserums. The complement-fixation curves observed in cross-reactions indicated close antigenic similarity between these two leukemia viruses. Highly purified viral preparations contained detectable amounts of host antigens.


Inhibitory activity of tannic acid and flavonols on the infectivity of Herpesvirus hominis and Herpesvirus suis.


Invasion of tumor cells into the bloodstream caused by palpation or biopsy of the tumor.


Virus-induced murine leukemia: its inhibition and suppression by serum containing erythropoietin. Mice infected at 2 days of age with a virus that induces reticulum cell sarcoma and myeloerythroleukemia were treated with erythropoietin-containing serum obtained from rabbits that had been treated with acetylphenylhydrazine. A marked inhibition of tumor induction occurred, particularly in females, when treatment was begun early. Delayed treatment resulted in instances of regression of overt neoplasia.


Pituitary melanocyte-stimulating hormone (MSH) after suckling stimulus.


Preparation and properties of growth hormone from equine pituitary glands.


Evidence for ACTH secretion and ACTH suppressibility in hypophysectomized rats with multiple heterotopic pituitaries.


Sources of error in the bio-assay of ACTH in the rat.


Are pathogenic spores a hospital threat?


The localisation of succinic dehydrogenase in the muscles of Nereis Virens and Homarus Gammarus.


Contaminant viruses in two live virus vaccines produced in chick cells.


Distribution of heat-resistant Clostridium welchii in a rural area of Australia.


Studies on the mechanism of destruction of lymphoid tissue in murine hepatitis virus (MHV3) infection. I. Selective prevention of lymphoid necrosis by cortisone and puromycin.


Radiation sensitivity of cells and base composition of DNA: an electron spin resonance study.


Further investigations of an assay in vitro for prolactin.


Pressor activity in extracts of the corpuscles of Stannius from the European eel (Anguilla anguilla L.).


Studies on D-glyceraldehyde-3-phosphate dehydrogenase. XXII. D-glyceraldehyde oxidation.


The direct effect of carbon tetrachloride on subcellular particles.


The chemistry of dermal necrosis.

The chemistry of dermal necrosis.


Changes in rat liver cells induced by orotic acid feeding.


Amyloidosis: origin from fixed periodic acid-Schiff positive reticuloendothelial cells in loco and basic factors in pathogenesis.


Application of the microtiter technique to the quantitation of adenovirus serotypes and their antisera.


The adrenocorticotrophic properties of alpha-melanophore-stimulating hormone.


Adrenal secretion after bilateral adrenalectomy for Cushing's syndrome.


Studies of infectious bovine rhinotracheitis virus. II. Effect of metabolic inhibitors on virus multiplication.


Studies on the biologic relationship of some murine leukemia viruses.


Inhibition of cellular RNA synthesis by nonreplicating vesicular stomatitis virus.


Isolation syndrome in the rat.

Isolation syndrome in the rat.


The biosynthesis of cyclitols.

The biosynthesis of cyclitols.


Effects of carbon dioxide-bicarbonate mixtures on oxidative phosphorylation by cauliflower mitochondria. 1. Carbon dioxide-bicarbonate mixtures markedly inhibited oxidation and phosphorylation rates of mitochondria prepared from cauliflower. Inhibition occurred with succinate, malate, citrate, isocitrate and NADH as substrates. 2. Indophenol-reductase systems with malate, succinate, isocitrate and NADH as substrates were inhibited by 5% and 15% carbon dioxide. Cytochrome c oxidase was not inhibited by 15% carbon dioxide.


The molecular structure of bacterial walls. The size of ribitol teichoic acids and the nature of their linkage to glycosaminopeptides. 1. Ribitol teichoic acids prepared by fractional precipitation of trichloroacetic acid extracts of bacterial cell walls are essentially undegraded and have similar chain length to the teichoic acid originally present in the walls. 2. The chain length of teichoic acid can be determined directly, without prior extraction from the wall. Accurate values have been obtained by measurement of the formaldehyde produced by oxidation of walls with periodate. Less accurate values have been derived from the amount of inorganic phosphate formed by heating walls at pH4. 3. The relative amounts of N-acetylglucosaminylribitol and its mono- and di-phosphates produced by heating walls of Staphylococcus aureus with alkali agree with the amounts calculated for the hydrolysis of teichoic acid having the chain length determined by other methods. 4. Chemical considerations indicate that the linkage between teichoic acid and the wall may involve a phosphoramidate bond between the terminal phosphate of the teichoic acid and one of the amino groups in the glycosaminopeptide.


Studies on the fractionation of mucosal homogenates from the small intestine. 1. Homogenates of the mucosa of the small intestine of the guinea pig were separated by fractional sedimentation into seven different fractions. The enzymic properties of some of these subcellular fractions were compared with those obtained from the mucosa of the small intestine of the rabbit and cat. 2. The enzymic properties of the low-speed sediment (15000g-min.) were investigated and it was shown that invertase and alkaline ribonuclease were predominantly located in this subcellular fraction, whereas alkaline phosphatase, aryl-amidase, acid phosphatase, acid ribonuclease and phosphoprotein phosphatase, though true constituents of this fraction, occurred to varying degrees in other subcellular structures also. 3. It was shown that the most probable source of the enzymic activities observed in the low-speed sediment was the brush border. Electron micrographs of the purified brush-border fraction indicated vesicles derived from the brush-border membrane. 4. A method is described for the fractionation of mucosal homogenates into a brush border-plus-nuclei fraction, a mitochondrial fraction, a microsomal fraction and a particle-free supernatant. The fractions were shown to be relatively pure, as indicated by the distribution of invertase, DNA, succinate dehydrogenase, glucose 6-phosphatase and 6-phosphogluconate dehydrogenase. 5. Most of the activity of four lysosomal enzymes present in the nuclei-free homogenate was sedimented at 375000g-min., suggesting the occurrence of lysosomal particles in mucosal homogenates. 6. Further fractionation of the microsomal membranes into three fractions is described. The enzymic composition of the membrane fractions is given and discussed in relation to their structure as seen in electron micrographs.


Electron transport in a Park-Williams strain of Corynebacterium diphtheriae. 1. The electron-transport mechanism was examined in the ;particulate' and ;supernatant' fractions of disintegrated cells of a Park-Williams strain of Corynebacterium diphtheriae. 2. Succinate-oxidase activity was found mainly in the ;particulate' fraction, and NADH(2) oxidase mainly in the ;supernatant', which was devoid of cytochromes and menaquinone. 3. The sum of the activities of particles and supernatant fractions, with respect to both succinate oxidase and NADH(2) oxidase, was substantially less than that of the crude cell extract from which they were obtained. Full activity was restored on recombining ;particles' and ;supernatant'. The characteristics of this reassembled system were investigated. 4. The strain of organism (CN2000) examined contained cytochromes corresponding spectroscopically to ;a', ;b' and ;c' types. All three were reduced by succinate, lactate or NADH(2); but a portion of the cytochrome b, susceptible to reduction by dithionite, could not be reduced by the substrates. 5. Triton X-100 inhibits oxidation of succinate by particulate fraction; on adding succinate, the reduction of cytochrome b is not affected but that of cytochromes a and c is delayed. 6. Irradiation at 360mmu completely destroys menaquinone in the particle fraction. Succinate oxidation is severely decreased; succinate dehydrogenase and NADH(2) oxidation are little affected. Certain menaquinones will restore succinate oxidation in the irradiated material. 7. On adding succinate to irradiated particulate material cytochrome b is partially reduced at once, but reduction of cytochromes a and c is much delayed. A portion of the cytochrome b remains not reduced, but reduction occurs rapidly on the addition of menaquinone (MK-2).


The immunochemistry of Salmonella chemotype VI O-antigens. The structure of oligosaccharides from Salmonella group G (o 13,22) lipopolysaccharides. 1. Lipopolysaccharides have been isolated from ;smooth' (S) strains of Salmonella friedenau and Salmonella poona by the phenol-water method and purified in the preparative ultracentrifuge. 2. These lipopolysaccharides are serologically indistinguishable and on partial acid hydrolysis the same series of oligosaccharides was obtained in each instance. 3. The results of quantitative micro-analysis, borohydride reduction, periodate oxidation, Morgan-Elson reactions and enzymic hydrolysis with beta-galactosidase on the isolated oligosaccharides indicate that the O-specific side chains of these lipopolysaccharides have a repeating pentasaccharide unit that is beta-d-galactosyl-(1-->3)-N-acetylgalactosaminyl-(1-->3)-N-acetylgalactosaminyl-(1-->4)-l-fucose with a d-glucose residue bound at an undetermined point on this structure. 4. Two oligosaccharides, a glucosyl-galactose and an N-acetylglucosaminylglucose, have also been isolated and these seem to be identical with oligosaccharides obtained from ;rough' (R) Salmonella lipopolysaccharides. These findings are in accordance with the view that Salmonella S-lipopolysaccharides have a core that consists of R-lipopolysaccharide.


Emphysematous gastritis associated with adenocarcinoma of the stomach.


Comparative studies on the electrical properties and enzyme activities in skins of Rana catesbeiana.


Further studies on acquired resistance to murine cryptococcosis: enhancing effect of Bordetella pertussis.


Studies on Japanese B encephalitis virus vaccines from tissue culture. V. Response of man to live, antenuated strain of OCT-541 virus vaccine.


The antigens of vesicular stomatitis virus. I. Separation and immunogenicity of three complement-fixing components.


Studies concerning the polishing properties of zirconium silicate on enamel.


Effects of Polybrene on adrenal cortex.

Effects of Polybrene on adrenal cortex.


Hoarseness, peripheral neuropathy, and diffuse nodular cutaneous lesions.


Pulmonary alveolar proteinosis. A study using enzyme histochemistry, electron microscopy, and surface tension measurement.


Congenital cerebral granulomas. Report of four cases in male siblings.


Quantitative determinations of phosphatase activities in Phallusia mamillata eggs and embryos.


Relationship of rehinovirus infection to mild upper respiratory disease. 3. Further epidemiologic observations in military personnel.


The Virus Watch program: a continuing surveillance of viral infections in metropolitan New York families. II. Laboratory methods and preliminary report on infections revealed by virus isolation.


Pleomorphic salivary gland adenoma of the tongue.


Antigenic studies on Sabin types 1 & 3 poliovaccine virus during 1 to 7 passages in the human intestinal tract.


The Virus Watch program: a continuing surveillance of viral infections in metropolitan New York families. 3. Preliminary report on association of infections with disease.


The effect of pH on transformation of BHK21 cells by polyoma virus. II. Kinetic considerations.


Rapid cytopathic changes and transformation in human foreskin cell cultures infected with simian virus 40.


Viral hepatitis with hepatic coma.

Viral hepatitis with hepatic coma.


Corticosteroids and corticotrophin in the treatment of Crohn's disease.


Observations on pancreatic islet cell and other radiation-induced tumors in the rat.


Electron microscopy of antigen precipitates extracted from gel diffusion plates.


Substituent effects on oxidation and stabilization of phenothiazine semiquinone free radicals.


The treatment tumours of the parotid gland.


Pulmonary oil deposition in patients subjected to lymphography: Detection by thoracic photoscan and sputum examination. During clinical trials of intralymphatic therapy with radioiodinated ethiodized oil (Lipiodol Ultra-Fluid; Ethiodol) [LUF-I(131)] for malignant disease involving lymph nodes, significant pulmonary deposition of radioactive material was demonstrated by thoracic scan in each of five cases treated. Radioactivity was detected in sputum obtained from two cases. Induced sputum specimens were subsequently obtained from patients undergoing lymphography. Fat demonstrated in sputum was confirmed as Lipiodol in one of six patients tested. Sputum examination and use of tracer doses of LUF-I(131) plus photoscanning are suggested as sensitive methods of assessing the incidence of oil deposition in the lungs of patients undergoing lymphography. Despite limitation of the volume of oil injected, monitoring of the infusion, and absence of radiographic evidence of contrast medium in the lungs, some degree of pulmonary oil deposition appears to be an inevitable result of lymphography. Further study of lung dosimetry is being undertaken by the authors before clinical usage of endolymphatic radioisotope therapy is expanded.


A study of the classification of male hypogonadism with observations on the control of 17-oxosteroid precursors from the testes and adrenals.


A fluorimetric determination of unconjugated cortisol in human urine after paper chromatography.


Comparison of effect of environmental and preoptic heating and pyrogen on plasma cortisol.


Paget's disease of the male breast. A case report.


The fine-structural localization of phosphatases in neurosecretory cells within the ganglia of certain gastropod snails.


Carcinoma of the parotid gland.

Carcinoma of the parotid gland.


Primary signet ring cell carcinoma of the urinary bladder.


Glandular tumors of the upper respiratory tract. A clinicopathologic assessment.


Advantages resulting from the addition of a versatile multichannel analyser to an electron spin resonance spectrometer.


Importance of the carboxyl end of bradykinin and other peptides.


Serological relationship between adenovirus haemagglutinins of group 2.


Treatment of malignant tumors.

Treatment of malignant tumors.


The use of SV 40-transformed cells for titrations of bovine viral diarrhoea and hog cholera viruses.


Hypopituitarism: a study of growth hormone and other endocrine functions.


Angiotensin-induced natriuresis in cirrhosis in the absence of endogenous aldosterone secretion.


The behavior of sterols on silica surfaces and at other interfaces.


Serum transport of vitamin D.

Serum transport of vitamin D.


Association of adenoviruses with bovine respiratory diseases.


Hepatic tumours in ducks fed a low level of toxic groundnut meal.


Soluble factors improving the phosphorylative efficiency of yeast mitochondria.


Evaluation of the demonstration of complement-requiring neutralizing antibody as a means for early diagnosis of herpes virus infections.


Observations of cortical nodules in human adrenal glands. Their relationship to neoplasia.


Human cytomegalovirus: properties of the complement-fixing antigen.


Clinical aspects of primary carcinoma of the liver.


The in vitro and in vivo effects of cortisol on interferon production and action.


A spin-labeled substrate for alpha-chymotrypsin.


A glucagon-secreting alpha-cell carcinoma of the pancreas.


Twisted circular DNA: sedimentation coefficients and the number of twists.


ESR study of gamma-irradiated polynucleotides.


The effects of nontumor viruses on virus-induced leukemia in mice: reciprocal interference between Sendai virus and Friend leukemia virus in DBA-2 mice.


Induction of cellular DNA synthesis by polyoma virus. 3. Induction in productively infected cells.


Heterogeneous RNA's occurring during the replication of Western equine encephalomyelitis virus.


The occurrence of enteroviruses in children from modern flats and squatter-dwellings in Singapore.


Sustained sinusoidal oscillations of reduced pyridine nucleotide in a cell-free extract of Saccharomyces carlsbergensis.


Interference of bovine viral diarrhea virus by hog cholera virus in swine kidney cell cultures.


Glycoprotein levels in cattle naturally and experimentally infected with Mycobacterium bovis.


Evidence for semiconservative replication of circular polyoma DNA.


Distribution of an antigen in avian leukoses demonstrable by immunofluorescence.


Clostridial infections of the abdominal wall: review of 10 cases.


Paget's diseases (cancer of the breast): clinical discussion and report of three cases.


A, B, and O substances in gastrointestinal carcinoma.


Neurologic state of persons exposed to continuous action of sodium dinitrophenolate.


Complications of lymphography.

Complications of lymphography.


Identification of analogues of nicotinamide adenine dinucleotide among the metabolites of 2,6-diaminopurine in mammalian cells.


Basal adrenocortical function in normal healthy Indians: effect of ACTH stimulation and metyrapone administration, as assessed by urinary steroid excretion.


Mixed function oxidation. V. Flavin interaction with a reduced diphosphopyridine nucleotide dehydrogenase, one of the enzymes participating in camphor lactonization.


Nursing students' attitudinal changes following a  psychiatric affiliation.


Anticipating the effects of program change.


Staff development: program evaluation.

Staff development: program evaluation.


Erythrocyte DPNH dependent diaphorase levels in infants.


On the respiratory spread of varicella-zoster virus.


Urinary excretion of ingestes alpha-aminioisobutyric acid-N-15 in dogs treated with growth hormone or corticotropin.


Observations on the release of histaminase after 48/80 and polymyxin B in sensitized and unsensitized rats.


Staff development: a responsibility of the employing agency.


Helping your retarded patients with hearing impairments.


Multiple virus infection of monkey kidney cells in culture.


Enhanced bacterial virulence in fluids produced in strangulation intestinal obstruction.


Fate of poliovirus in northern quahaugs.


Serologic relationships of the B632 and ECHO-28 rhinovirus strains.


Survival after pulmonary lobectomy for metastatic adrenocortical carcinoma.


Experiences with malignant brain tumours in clinic and in tissue culture.


A community mental health service based on principles of family psychiatry.


Intimal sclerosis in human veins.

Intimal sclerosis in human veins.


They were dressed.

They were dressed.


Hypoallergenic cosmetics.

Hypoallergenic cosmetics.


Ward staffing the state mental hospital.


Brain abscess due to gas bacillus infection. Report of a case.


The surgery of the deep lobe of the parotid salivary gland.


The role of the psychiatric aide--a need for reconceptualization.


Appraisal of selective angiography in localizing islet-cell tumors of the pancreas.


Useful procedures for the determination of complex fatty acid composition. Occurrence of trans-5-hexadecenoic and trans-5,cis-9-octadecadienoic acids in the oil from Thalictrum venulosum.


Effect of adrenocorticotropic hormone on cholesterol level in rat liver in vitro.


Hemagglutinating and plaque forming properties of two substrains of simian parainfluenza virus SV5.


Possible mechanisms of appearance and disappearance of free-radical states in cells.


Effect of promazine on activity of certain liver and blood enzymes in carbon tetrachloride poisoning.


Studies on the nature of the virus inactivating capacity of sea water.


Formation of virus particles via enzyme systems and structural proteins induced by another, "assistant" virus.


Characteristics of the progeny derived from multiplication of Sendai virus in a measles virus carrier cell line.


Effect of Coxsackie viruses of group A and B on Rous sarcoma virus.


Enhancement of infectivity of poliovirus RNA with diethylaminoethyl-dextran (DEAE-D).


Physico-chemical investigation of an enteric cytopathogenic bovine orphan virus, ECBO SA.I.


Role of the optic ganglia in learning in the crayfish Procambarus clarki (Girard).


Varicella virus in HeLa cells.

Varicella virus in HeLa cells.


Interaction of a simian papovavirus and adenoviruses. I. Induction of adenovirus tumor antigen during abortive infection of simian cells. Feldman, Lawrence A. (Baylor University College of Medicine, Houston, Tex.), Janet S. Butel, and Fred Rapp. Interaction of a simian papovavirus and adenoviruses. I. Induction of adenovirus tumor antigen during abortive infection of simian cells. J. Bacteriol. 91:813-818. 1966.-Adenovirus types 2, 7, and 12 undergo an abortive growth cycle in green monkey kidney cells; they induce the formation of adenovirus tumor antigen, but synthesis of adeno capsid antigen and infectious adenovirus was observed only when cultures were concomitantly infected with a simian papovavirus (SV40). Several other viruses, including herpes simplex and measles which replicate in monkey cells, and rabbit papilloma and human wart papovaviruses which do not, failed to stimulate adenovirus replication in the monkey cells. Adenovirus tumor antigen was detected 8 to 10 hr postinfection by immunofluorescent techniques. The antigen induced by adenovirus types 2 and 7 appeared as intranuclear masses; adenovirus type 12 tumor antigen also appeared as cytoplasmic and nuclear flecks. Sera from hamsters bearing tumors induced by adenovirus type 12 cross-reacted with tumor antigens induced by types 2 and 7 but not with antigens induced by SV40.


Assessment of adrenocortical function in the course of viral hepatitis.


Studies on transformation of Syrian hamster cells by simian virus 40 (SV40): acquisition of oncogenicity by virus-exposed cells apparently unassociated with the viral genome.


Specific degradation of the collagen molecule by tadpole collagenolytic enzyme.


Possible incorporation of SV40 genome within capsid proteins of adenovirus 4.


Increase of malignant potential of BHK-21 cells by SV40 DNA without persistent new antigen.


The synthesis of alpha-ketoglutarate from succinate and carbon dioxide by a subcellular preparation of a photosynthetic bacterium.


Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.


Sulphydryl "nothing dehydrogenase" activity and lactic dehydrogenase-NADH2 cytochrome C reductase reactions in tissues of the human foetus.


A rapid kinetic method for determination of serum alpha-hydroxybutyrate dehydrogenase.


Double cancer of the stomach: report of two cases.


Studies on the metabolism of carbon monoxide.


Genetic factors in resistance against virus infections.


Synthesis and transport of protein components of Sendai Virus.


Thermal inactivation of 32P-poliovirus at 37 degrees C and 50 degrees C in the presence of NaCl with high molarity.


Density gradient centrifugation studies of vesicular stomatitis virus.


Mouse macrophages as host cells for murine viruses. (Brief report).


Replication of gross leukemia virus in long-term cultures of rat thymomas: bioassays and electron microscopy.


Polyribosomes in rat tissues. IV. On the abnormal dimer peak in hepatomas.


Immunology of spontaneous mammary carcinomas in mice IV. Association of the mammary tumor virus with the immunogenicity of C3H nodules and tumors.


The fine structure of the Yaba monkey tumor poxvirus.


Free radical concentration in irradiated bacterial spores and vegetative cells as measured by the ESR method.


The effects of fluorocarbon on preparations of a leukemia virus (Gross).


Production of free radicals in solid biological substances by heavy ions.


Some effects of tumor implantation site on tumor-host relations.


Effect of the irradiation temperature on the production of free radicals in solid biological compounds exposed to various ionizing radiations.


Influence of bacille Calmette-Guérin infection on polyoma in hamsters and mice.


Tumors in the rat after injection of neoplastic and preneoplastic nucleic acids.


Enzymes of nucleic acid metabolism in cells infected with polyoma virus.


Nucleoside kinase activities in tissues infected with Rous sarcoma virus.


The activity of streptonigrin against the Rauscher murine leukemia virus in vivo.


Action of streptolysin S, the group D hemolysin, and phospholipase C on whole cells and spheroplasts. Davie, Joseph M. (Indiana University, Bloomington), and Thomas D. Brock. Action of streptolysin S, the group D hemolysin, and phospholipase C on whole cells and spheroplasts. J. Bacteriol. 91:595-600. 1966.-The effect of streptolysin S, the group D hemolysin, and phospholipase C (the alpha toxin of Clostridium perfringens) on whole cells and spheroplasts or protoplasts of three strains of streptococci and Micrococcus lysodeikticus was tested. Viability, C(14)-glycine uptake, and lysis were measured. The group D hemolysin and phospholipase C were active against whole bacteria; streptolysin S was not. All three substances were active on spheroplasts. A partially resistant mutant derived from a strain sensitive to the group D hemolysin was also partially resistant to streptolysin S and phospholipase C. Antimycin A protected spheroplasts from streptolysin S but not from the group D hemolysin.


Development of antigens in human cells infected with Simian virus 40. Bissett, Marjorie L. (University of Michigan, Ann Arbor), and Francis E. Payne. Development of antigens in human cells infected with simian virus 40. J. Bacteriol. 91:743-749. 1966.-An explanation for the apparent infrequency with which human cells transform in response to exposure to simian virus 40 (SV40) was sought by following the development of virus-induced antigens in human euploid cells, strain CR. For about 8 weeks after exposure to a high multiplicity of SV40, only a small proportion of the cells produced tumor (T) or viral (V) antigen detected by immunofluorescence. Double-tracer staining techniques revealed that the development of T and V antigen in about 1% of the CR cells resembled that in green monkey kidney cells, strain BS-C-1, in which SV40 replicates and destroys all the cells. T antigen was detected before V antigen; both antigens were detected in the nucleus, but only V antigen appeared later in the cytoplasm. All intact cells that contained V antigen also contained T antigen. Infected CR cell cultures, before and after transformation or when in "crisis," contained only 0.1 to 1.0% of cells with both V and T antigen. Some CR cells contained only T antigen, and by 8 days after exposure to virus these cells were present as loose foci associated with an occasional cell containing V antigen. The proportion of CR cells with only T antigen increased from about 1% during the first 4 weeks to 8% at 7 weeks, and to nearly 100% at 11 weeks, when essentially all of the cells were epithelioid. Foci of epithelioid cells were first recognized in the 9th week. It was concluded that those CR cells that contained T antigen at any given time represented (i) a few cells that subsequently produced V antigen and lysed, and (ii) a progressively increasing population that produced only T antigen. If the latter population, in whole or in part, gave rise to the epithelioid transformed cells, then its initial size could account, at least in part, for the apparent infrequency with which human cells transform in response to SV40.


Nitrate reductase and respiratory adaptation in Bacillus stearothermophilus. Downey, R. J. (University of Notre Dame, Notre Dame, Ind.). Nitrate reductase and respiratory adaptation in Bacillus stearothermophilus. J. Bacteriol. 91:634-641. 1966.-Bacillus stearothermophilus 2184 required nitrate to grow in the absence of oxygen. Like many facultative microorganisms, the growth obtained anaerobically was considerably less than that obtained aerobically, even though the dissimilatory reduction of nitrate is, in effect, anaerobic respiration. The ability to reduce nitrate depended on the induction of nitrate reductase. Although oxygen at low levels did not retard induction of the enzyme, enzyme synthesis was considerably lessened by aeration. A semisynthetic medium containing nitrate supported aerobic growth of the thermophile but did not support anaerobic growth. The adaptation to nitrate resulted in a decrease in the level of cytochrome oxidase normally present in aerobically grown cells. Although the aerobic oxidation of succinate by the respiratory enzymes from aerobically grown cells was inhibited by 2-N-heptyl-4-hydroxyquinoline-N-oxide, the anaerobic oxidation of succinate by nitrate in a similar preparation from nitrate-adapted cells was not. The nitrate reductase in the bacillus was strongly inhibited by cyanide and azide but not by carbon monoxide. The nitrate reductase catalyzed the anaerobic oxidation of reduced nicotinamide adenine dinucleotide, and appeared to transfer electrons from cytochrome b(1) to nitrate. Cytochrome c(1) did not appear to be involved in the transfer.


Biophysical studies of vesicular stomatitis virus. McCombs, Robert M. (Baylor University College of Medicine, Houston, Tex.), Matilda Benyesh-Melnick, and Jean P. Brunschwig. Biophysical studies of vesicular stomatitis virus: J. Bacteriol. 91:803-812. 1966.-The infectivity and morphology of vesicular stomatitis virus (VSV) were studied after density gradient centrifugation in cesium chloride (CsCI), potassium tartrate (KT), and sucrose. Centrifugation in CsCl revealed two equally infectious bands corresponding to densities of 1.19 and 1.22 g/ml, and a third (density, 1.26 g/ml) band of low infectivity. Two bands (densities of 1.16 and 1.18 g/ml) were observed in the KT gradient, in which the lighter band contained most of the infectivity. Centrifugation in sucrose resulted in a single broad infectious band (density, 1.16 g/ml). The typical rod-shaped VSV particles were found mainly in the lighter bands obtained in CsCl (1.19 g/ml) and KT (1.16 g/ml) and in the single sucrose gradient band (1.16 g/ml). Bent particles equally as infectious as the rod-shaped particles were a constant finding in the CsCl preparations, and were observed mainly in the second band (density, 1.19 g). Numerous strands 15mmu wide were found in the third CsCl (density, 1.26 g/ml) and the second KT (1.18 g/ml) bands. Similar strands could be liberated from VSV particles after treatment with deoxycholate. Internal transverse striations were found to be a regular feature of VSV particles examined with the pseudoreplication negative-staining technique. For crude virus stocks, the physical particle-to-infectivity ratio ranged from 73 to 194. Several morphological similarities between VSV and myxoviruses were observed, including 10 mmu surface projections, pleomorphic morphological forms, and 15 mmu seemingly nucleoprotein strands.


Hydrolytic enzymes in KB cells infected with poliovirus and herpes simplex virus. Flanagan, John F. (Duke University School of Medicine, Durham. N.C.). Hydrolytic enzymes in KB cells infected with poliovirus and herpes simplex virus. J. Bacteriol. 91:789-797. 1966.-The effect of poliovirus and herpes simplex virus infection on the activity of five hydrolytic enzymes was studied in tissue culture cells of KB type. During the course of poliovirus infection, the activity of beta-glucuronidase, acid protease, acid ribonuclease, acid deoxyribonuclease, and acid phosphatase in the cytoplasm rose to levels two- to fourfold greater than the activity present in the cytoplasm of uninfected cells. The rise in cytoplasmic activity was accompanied by a concomitant decrease in enzymatic activity bound to cell particles. Shift of enzymatic activity from the particulate to soluble state was first detected at 6 hr after poliovirus infection, coinciding with the appearance of new infectious particles and virus cytopathic effect. No net synthesis of these enzymes after poliovirus infection was found. Hydrocortisone added to the culture medium failed to affect either the titer of virus produced in the cells or the release of hydrolytic enzymes from the particulate state. Herpes simplex infection produced minimal alterations in the state of these enzymes in KB cells. It is hypothesized that the breakdown of lysosomes and release of hydrolytic enzymes accompanying poliovirus infection is produced by alterations in cell membrane permeability during the course of virus replication and by the consequent change in the ionic content of the cell sap.


Renal arterial hypertension. Incidence, diagnosis and treatment.


Pathophysiology and biochemistry of end-stage hypertensive heart disease.


Rhinoviruses and common colds.

Rhinoviruses and common colds.


Some observations on the activity of oxidative enzymes in Poxvirus variolae infected FL and L cell cultures.


Formation of 4-methyl-3-pentenoic acid from cholesta-5, 24-dien-3-beta-ol by adrenal enzyme.


The nature and classification of ovarian neoplasms. The classification of ovarian neoplasms on a histogenetic basis according to presentday concepts of development and structure of the ovary is considered. There are four histogenetic categories of primary ovarian tumours: neoplasms of germ cell origin, neoplasms of celomic (germinal) epithelium and its derivatives, neoplasms of specialized gonadal stroma (sex cords and mesenchyme), and neoplasms of non-specialized gonadal stromal and heterotopic elements. In patients of all ages, 70% of ovarian neoplasms were of celomic epithelial origin, 16% of germ-cell origin, 5% of specialized gonadal stromal origin, and 9% arose from the non-specialized stroma and heterotopic elements. Before 20 years of age, 59% of ovarian neoplasms were of germ cell origin and before puberty they accounted for 90% of all ovarian tumours. The different structural types of neoplasms within the four categories are described. Accurate classification of ovarian neoplasms on a histogenetic basis is stressed if proper treatment is to be given and intelligent assessment of end results is to be made.


Feedback effect of corticosteroids at the adrenal level.


Studies on the transformation of bovine cells in vitro by SV40, and the properties of the transformed cells.


Effect of inhibitors on induction of SV40 tumor antigen by an adenovirus-SV40 hybrid.


The effect of mercurials on the integrity of the poliovirion.


Electrical and mechanical responses of vascular smooth muscle to vasodilator agents and vasoactive polypeptides.


Reflex inhibition of sympathetic vasoconstrictor activity at a peripheral locus.


Histochemical study of the olfactory bulb in the rodent.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. VII. Oxidative phosphorylation in the diphosphopyridine nucleotide-cytochrome b segment of the respiratory chain: assay and properties in submitochondrial particles.


Biophysical study of the mode of action of the tetracycline antibiotics. Inhibition of metalloflavoenzyme NADH cytochrome oxidoreductase.


Growth stimulating activities of vitamin-dependent enzymes in fresh liver for rainbow trout fingerlings.


Glyoxylate reductase activity of lactate dehydrogenase.


Detection of cells from extramammary Paget's disease of the vulva in a vaginal smear. Report of a case.


Complications following lymphography with particular reference to pulmonary oil embolization.


Live and killed adenovirus vaccines for the prevention of acute respiratory disease in recruits.


Effect of caffeic acid on mouse and ferret lung infected with influenza A virus.


Effect of iododeoxyuridine on encephalomyocarditis virus.


Nature of the antiviral activity of statolon.


Distamycin A, a new antiviral antibiotic.


Antiviral activity of distamycin A.

Antiviral activity of distamycin A.


Properties of a virus variant derived from drug-treated mice infected with A-PR8 influenza virus.


Effect of adrenocorticotropin on the concentration of triglyceride in the adrenal gland of the hypophysectomized rat.


Influence of ACTH, food restriction and electric shock on total vitamin A in the rat adrenal gland and on its quantitative histological distribution.


Effects of various growth hormone preparations on dog adrenal cortical secretion.


The determination by quantitative histochemistry of the effect of phenothiazines on brain cytochrome C oxidase activity.


Distribution patterns of oxidative enzymes in experimentally induced tumors, regeneration and inflammation of mouse skin.


Relationships among visceral lymphomatosis, bursa of Fabricius, and bursa-dependent lymphoid tissue of the chicken.


Susceptibility and resistance to viral leukemogenesis in the mouse. 3. Effect of added thymus tissue from a susceptible strain upon the response of two resistant strains.


Variation of antigenic characteristics between different mouse lymphomas induced by the Moloney virus.


Loss of transplantation antigen in primary simian virus 40-induced tumors and their metastases.


Role of the milk agent in disappearance of mammary cancer in C3H/StWi mice.


Papovavirus SV40 transplantation immunity conferred by an adenovirus-SV40 hybrid.


Susceptibility of mammary tissues of "genetically resistant" strains of mice to mammary tumor virus.


Effects of partial hepatectomy of rats on the metabolism of formate-C 14 in vivo by host liver and Morris hepatoma 5123-C.


Comparison of the immediate effects of 4 vasopressors on renl blood flow.


Leukemia in man and mouse.

Leukemia in man and mouse.


Species specificity in reaction between renin and angiotensinogen.


Direct action of adrenocorticotrophic hormone on lipase in the adrenal gland of the rat.


Growth of foot and mouth disease virus in organ cultures of mouse pancreas.


Non-heritable interferon resistance in a fraction of virus populations.


Studies of relationship between mouse cytomegalovirus and interferon.


Viral spectrum of an established chimpanzee liver cell line.


Plaque assay for mouse hepatitis virus (MHV-2) on primary macrophage cell cultures.


Effect of vitamin D deficiency on the crystal chemistry of bone mineral.


Antigenic relationship of the human and bovine parainfluenza 3 viruses using the Ouchterlony technique.


Luteoma of pregnancy.

Luteoma of pregnancy.


Luteomas of pregnancy.

Luteomas of pregnancy.


Spontaneous and voluntary electrical activity in neuromuscular disorders.


Isolation of variant strains from foot-and-mouth disease virus propagated in cell cultures containing antiviral sera.


Intrathoracic carotid-body tumour (chemodectoma).


Angiotensin infusion test in hypertension.


Effects of combined hormone therapy on erythropoiesis in the intact rabbit.


Injuries of peripheral nerves--principles of treatment.


Bilateral synchronous spike wave electrographic patterns in the cat. Interaction of bilateral cortical foci in the intact, the bilateral cortical-callosal, and adiencephalic preparation.


Myoblastoma of the tongue.

Myoblastoma of the tongue.


Cytochrome oxidase in latent iron deficiency (sideropenia).


Acidophil adenoma of the pituitary gland and other neoplasms in a boxer.


Eccrine spiradenoma. Histochemical and electron microscopic studies.


Changes of the sella turcica in chromophobic adenomas and eosinophilic adenomas.


The Atascadero story.

The Atascadero story.


The role of the reticuloendothelial system (RES) on blood lipid alterations and atherogenesis in cholesterol-oil fed and estrogen treated cockerels.


An experience with the use of group work methods and process with student nurse groups over a period of 5 years.


Dusk to dawn.

Dusk to dawn.


Absentee patients; a controlled study of missed appointments in a psychiatric clinic.


Micro-NMR in high permanent magnetic fields. Theoretical and experimental investigations with an application to the secretions from single glandular units in the human uterine cervix.


Precipitating antibody response to herpes simplex virus in rabbits after herpetic keratoconjunctivitis.


The effect of a synthetic beta-1-24-eikosatetrapeptide corticotropin (30'920-Ba Ciba) on plasma corticoids and the urinary 17-KS and 17-OHCS.


Speaking out.

Speaking out.


International trends.

International trends.


Unconscious motivation in medication errors.


Cytomegalovirus infection and cytomegalic inclusion disease in renal homotransplant recipients.


Cirrhosis and hepatoma in a child.

Cirrhosis and hepatoma in a child.


Are drugs safe?

Are drugs safe?


Geriatrics.

Geriatrics.


The effect of adenosine triphosphate, inorganic pyrophosphate and inorganic tripolyphosphate on the stability of cod myosin.


The redox state of NAD+-NADH systems in rat liver during ketosis, and the so-called "triosephosphate block".


Effects of calcium omission on acetylcholine-stimulated amylase secretion and phospholipid synthesis in pigeon pancreas slices.


Transtympanic approach to extratympanic (jugular bulb) chemodectoma.


Adenosine 3',5'-phosphate and oscillations of DPNH in a cell-free extract of Saccharomyces carlsbergensis.


A model for the purification of viruses for the production of specific immune serum.


On the participation of neuraminidase-sensitive sialic acid in the K+-dependent phosphohydrolysis of p-nitrophenyl phosphate by isolated rat-liver plasma membranes.


The homolog of the pituitary-adrenocortical axis in the teleost fish Tilapia mossambica.


The epidemiology of a herpes virus infection of New World monkeys.


Enterovirus hemagglutination: inhibition by aldoses and a possible mechanism.


Infectious bovine rhinotracheitis abortion and its relationship to nutrition in California beef cattle.


Fine structure of the prostatic epithelium of the opossum (Didelphis virginiana Kerr).


Growth and cytochrome c oxidase activity in minute mutants of Drosophila.


Kinetic criteria of solid state mechanisms in biology.


Influence of polymyxin B and normal rabbit serum on erythrocyte modifying capacity of common enterobacterial antigen.


Respiratory syncytial virus epidemic.

Respiratory syncytial virus epidemic.


DNA synthesis in rat embryo cells infected with polyoma virus.


The early synthesis of RNA in polyoma virus development.


Early events in the eclipse phase of influenza and parainfluenza virus infection.


Glucocorticoid suppression from aldosteronomas.


Granular cell myoblastoma of the breast.


Calcification pancreatic carcinoma.

Calcification pancreatic carcinoma.


Enzyme induction in SV40-infected green monkey kidney cultures.


Strain-specific mammary tumor virus activity in blood of C3H and BALB-c f. C3H mice.


Mammary tumor virus activity in red blood cells of BALB-c f. C3H mice.


Bizarre gastric leiomyoblastoma simulating a pedunculated uterine fibromyoma.


Congenital and acquired cytomegalovirus infection.


Symposium on replication of viral nucleic acids. 3. Replication of mengovirus ribonucleic acid.


An histologic and histochemical study of familial osteoectasia. (Chronic idiopathic hyperphosphatasia).


The association of aniridia, Wilms' tumor, and genital abnormalities.


Aberrant salivary tumours. (Report of four cases).


Immunology of the mouse mammary tumour virus (MTV): a qualitative in vitro assay for MTV.


Kinetic differences between human red cell and leucocyte pyruvate kinase.


Mycotoxicosis: toxic fungi in tobaccos.

Mycotoxicosis: toxic fungi in tobaccos. Cigarette, cigar, and pipe tobaccos contain Alternaria spores and dematiaceous mycelia, with cigarette tobaccos being more heavily laden. A smoke aerosol generated from hay on which the fungus had been cultured caused, among other pathologic changes, pulmonary emphysema in mice.


Satellites and nursing care.

Satellites and nursing care.


Growth-hormone deficiency in man: an isolated, recessively inherited defect. A deficiency of human growth hormone not associated with other pituitary deficiencies was observed in midgets with sexual ateliosis, a form of dwarfism inherited as an autosomal recessive trait. Body proportions, sexual development, birth weight, and postpartum lactation are normal in this syndrome.


Nursing: yesterday, today and tomorrow.

Nursing: yesterday, today and tomorrow.


The limited role of attenuated smallpox virus in the management of advanced malignant melanoma.


Center for the treatment of gestational trophoblastic neoplasms.


Possible "allosteric" effects controlling the kinetic behavior of amino acid-dependent pyrophosphate exchange reactions.


A nuclease specific for heat-denatured DNA in isolated from a product of Aspergillus oryzae.


The reaction of radicals induced in Escherichia coli B-r by gamma-rays with cysteamine and with oxygen.


Studies of the primary structure of 18-S + 28-S ribonucleates.