Ossification sequence polymorphism and sexual dimorphism in skeletal development.


Cryosurgery of the pituitary in acromegaly: reduced growth hormone levels following hypophysectomy in 13 cases.


Odontodysplasia.

Odontodysplasia.


The effect of metal ions on free radical formation and reactions in irradiated proteins.


Mediastinal lymph node visualization by lymphography. Report of a case.


Nobel Prize.

Nobel Prize.


Effects of actinomycin D on avian myeloblast and BAI strain A virus RNA synthesis in vitro.


Ultrastructural alterations in avian leukemia myeloblasts exposed to actinomycin D in vitro.


Hepatic carcinogenesis in thyroidectomized rats: apparent blockade at the stage of initiation.


Nucleic acid interactions. A molecular approach to the study of genes and their products.


Neoplastic transformation.

Neoplastic transformation.


Implantation of the rat embryo: glycogen and alkaline phosphatases.


Failure of orally administered perchlorate to affect deciduoma formation or pregnancy in the rat.


The incidence of spontaneous deciduomata in pseudopropregnant rats.


Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia.


Thiamine pyrophosphate hydrochloride: stereochemical aspects from an x-ray diffraction study. The crystal structure of thiamine pyrophosphate has been determined by a three-dimensional x-ray analysis. The conformation of the molecule in the crystalline state is determined by the formal charge distribution within the molecule which exists as a zwitterion with the negative pyrophosphate chain folded back over the positive, ring portion of the molecule. The oxygen atoms in the pyrophosphate group are in the staggered conformation when viewed along the phosphorus-phosphorus axis. Even though the pyrophosphate is present in this compound as the monoionized monoester, the configuration is the same as that present in the inorganic pyrophosphate ion. From a comparison of three different crystal structures containing the thiamine moiety and from studies with atomic models, it seems plausible that the basic molecular conformation observed in this crystal is maintained in the catalytically active molecule. Knowledge of the detailed crystal structure provides new insight into the biochemical mechanism of reactions catalyzed by thiamine pyrophosphate.


Feedback inhibition of key glycolytic enzymes in liver: action of free fatty acids. Increasing concentrations of sodium octanoate were progressively inhibitory to the activities of glucokinase, hexokinase, phosphofructokinase, and pyruvate kinase. Glucose-6-phosphate and 6-phosphogluconate dehydrogenases were also markedly inhibited. Other enzymes of carbohydrate metabolism such as lactate dehydrogenase, phosphohexose isomerase, and fructose-1,6-diphosphatase were not decreased. Among the key glycolytic enzymes, the inhibition of pyruvate kinase by the fatty acid was most marked. The biological significance of the inhibition of the key glycolytic enzymes is interpreted as a feedback inhibitory mechanism in regulation of fatty acid biosynthesis. The mechanism may function for rapid adaptation by which the organism can use the fatty acid level as a metabolic directional switch in decreasing glycolysis and turning on gluconeogenesis.


Insulin-secreting islet-cell tumour of the pancreas.


Renal angiotensinase activity. Its localization and the effects of mercury.


Effect of adrenergic antagonists on the peripheral constrictor action of kinekard, a cardioactive plasma fraction.


Potentiation of vascular myotropic responses by metanephrine and other noncatecholamines.


Release of adrenal catecholamines by angiotensin. II.


Contraction of vascular smooth muscle in response to plasma. Comparison with response to known vasoactive agents.


The experimental production of ischemic facial paralysis.


Evaluation of ACTH reserve in pituitary-hypothalamic disease.


Reserpine in experimental cerebral edema.


Potentiation of SV40 replication in human cells by adenovirus 4.


Surgical intervention during chemotherapy of gestational trophoblastic neoplasms.


Ultrastructure of human primary hepatic carcinoma.


Cyclic hormonetherapy. A report on 305 cases.


Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy. A filtrable agent separable from transplantable malignant lymphomas of NZB/Bl mice was capable, upon inoculation into preweanling NZB/Bl mice, of inducing lymphoid cell hyperplasia, hypergammaglobulinemia, proteinuria, hypoalbuminemia, and pathological changes (focal membranous glomerulonephritis) of kidneys-renal functional and structural changes qualitatively similar to those of spontaneous occurrence in older NZB/Bl mice. Viruslike particles with close resemblance to the typical "C" type murine oncogenic virus particles were identified by means of electron microscopy in NZB/Bl mouse tissues and cells, including malignant lymphoma cells, benign lymphoid cells of thymus and spleen, epithelial cells of renal tubules, and extracellular sites. The relevance of these observations, the first of their kind dealing with NZB/Bl mice, is discussed in relation to the several immunopathological disorders which characterize this strain of mice.


Role of newborn monkeys in the study of viral oncogenesis.


Studies on the heterologous immunogenicity of a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). II. Protection against tumor isografts. A methanol-insoluble residue (MER) of phenol-killed attenuated tubercle bacilli (BCG), which has been reported previously to be capable of evoking heightened resistance to infection with antigenically unrelated microorganisms, was found to affect as well the resistance of highly inbred mice against tumor isografts. In most instances, the MER evoked heightened resistance against the tumor implants, but heightened susceptibility was the effect induced against two of the tumors tested, and no effect was elicited against one neoplasm. It is suggested that the heightened susceptibility occasionally produced by pretreatment with MER may also be of immunological nature, i.e. immunological enhancement. Treatment with MER was more effective when administered some time before tumor challenge than when given simultaneously with, or after, tumor implantation. The protective effects manifested against some tumors were of a high order, a significant number of animals rejecting the neoplastic implants, and were displayed even when several months elapsed between treatment and challenge. Living BCG and intact phenol-killed bacilli also evoked heightened resistance against some of the tumors tested, and in one experiment living BCG proved effective whereas MER did not. On the whole, however, MER was the most active (and least toxic, as shown previously) of the several tubercle bacillus preparations tested. MER elicited heightened reactivity against first transplant generation tumors as well as against tumors maintained for considerable periods of time by repeated animal passage, and against spontaneously arising as well as against induced neoplasms. The experimental parameters necessary to demonstrate maximal effects varied somewhat from tumor to tumor. In general, however, single intraperitoneal injections of small quantities of MER, of the order of 0.25 to 1.0 mg, afforded the best protection.


Histochemical studies of the juxtaglomerular apparatus of the kidney of a white rat.


Inactivation and induction of electron spin resonance-centres in trypsin by ionizing radiation and by ultra-violet light.


Certain aspects of adrenocortical function and carbohydrate--lipid metabolism in obese patients. 3. Pituitary--adrenal reserve in obese persons.


Incompatibility of synthetic tetraicosapeptide corticotrophin with the present USP and International Corticotrophin Standard.


Histomonas meleagridis and several bacteria as agents of infectious enterohepatitis in gnotobiotic turkeys.


Effect of ethanol on ethylene glycol oxidation by mammalian liver enzymes.


Cytology and cytochemistry of the chemoreceptor cell in man.


A diurnal rhythm in plasma renin activity in man.


Urological spectrum of adrenal surgery.

Urological spectrum of adrenal surgery.


Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man.


Virulence and immunogenicity in mice of airborne encephalomyocarditis viruses and their infectious nucleic acids.


Steroid nephropathy. A case of renal disease showing similar changes of lipoid nephrosis modified by steroid treatment.


Enzyme histochemistry of human brain tumors and their tissue cultures with special reference to the oxidoreductases in the glioblastoma multiforme.


Control of glycolysis in the human red blood cell.


Enhancing effect of nucleic acids and their derivatives in the reduction of cytochrome c by ferrous ions.


Electron transport systems of the chemoautotroph Ferrobacillus ferrooxidans. II. Purification and properties of a heat-labile iron-cytochrome c reductase.


Differential effects of mercurial on the lipoyl reducatase and diaphorase activities of lipoyl dehydrogenase.


The incorporation of nucleotides into amino acid transfer ribonucleic acid. 3. Thincorporaton of uridylic acid.


Effect of adrenocorticotropin and other hormone preparations upon the metabolism of acetate-1-14C and other 14C-labeled substrates by adipose tissue in vitro.


The role of transfer ribonucleic acid in the pyrophsphate exchange reaction of arginine-transfer ribonucleic acid synthetase.


Paget's carcinoma of larynx.

Paget's carcinoma of larynx.


The combined effect of monoamine oxidase inhibitors and corticosteroids on the pituitary-gonadal system of male rats.


The induction of hepatitis by prior partial hepatectomy in resistant adult rats injected with H-1 virus. Light and electron microscopy and virologic studies.


Experimentallly induced hyperfunction of the pituitary-adrenal zona fasciculata system in the rat.


The effect of adenohypophysectomy on the extrarenal and renal excretion of the saline-loaded duck(Anas platyrhynchos).


The role of plasma free fatty acids in the elevation of plasma cholesterol and phospholipids produced by adrenaline.


The diagnosis of Japanese encephalitis by means of fluorescent antibody technique in autopsy cases.


The neuropathology of encephalitis Japonica in humans especially from subchronic to chronic stage.


Inactivation of viruses by benzalkonium chloride. Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 C or at room temperature. Poliovirus and encephalomyocarditis virus were not inactivated under the same conditions. It was concluded that all viruses tested were sensitive except members of the picorna group. The literature was reviewed.


An electron microscopic study on the fine structures of cerebral cortex in the mice infected with Japanese encephalitis virus.


Hepatic gluconeogenic enzymes, RNA metabolism and amino acid levels in rats carrying transplantable growth hormone-secreting pituitary tumors.


The influence of pH on the apparent oxidation-reduction potential of heart muscle succinic dehydrogenase.


Mammalian alpha-keto acid dehydrogenase complexes. I. Isolation, purification, and properties of pyruvate dehydrogenase complex of pig heart muscle.


Bacterial degradation of biotin. Catabolism of 14C-biotin and its sulfoxides.


Studies on dihydronicotinamide adenine dinucleotide ubiquinone reductase. I. Assay of ubiquinone reductase activity in submitochondrial particles and extracts.


Effect of purines on epinephrine-induced lipolysis in adipose tissue.


Measurement of guanosine 3',5'-monophosphate and other cyclic nucleotides. Variations in urinary excretion with hormonal state of the rat.


Effect of essential fatty acids deficiency upon the lipidic composition and enzymatic activity of rat mitochondria.


A roentgenographic analysis of respiratory syncytial virus pneumonia in infants.


"Pig-bel": clostridial food poisoning.

"Pig-bel": clostridial food poisoning.


Fibro-angioma of the facial nerve.

Fibro-angioma of the facial nerve.


Intracranial metastasis of sweat gland carcinoma. Case report.


Hypophosphatasia: genetic and dental studies.


The antigens of vesicular stomatitis virus. II. The presence of two low molecular weight immunogens in virus suspensions.


Factors affecting sodium reabsorption by the proximal tubule as determined during blockade of distal sodium reabsorption.


Effect of Merthiolate on agar gel diffusion precipitin reactions with foot-and-mouth disease virus.


Generalized type 5 adenovirus infection associated with the pertussis syndrome.


Infantile myoclonic seizures: an evaluation of ACTH and corticosteroid therapy.


Paget's disease of the nipple.

Paget's disease of the nipple.


Primary carcinoma of the liver in infancy and childhood: report of 21 cases, with resection in 6 cases.


Localization of tissue sodium and potassium compartments in rabbit renal cortex.


Indirect action of angiotensin infusion to inhibit renal tubular sodium reabsorption in dogs.


Relative efficiency of three tissue culture systems for the primary isolation of viruses from feces.


Association of adenoviruses with other than respiratory illness.


Persistance of adult Trichinella spiralis in pertussis-treated mice.


An evaluation of the B-V (continuous-flow) and B-IV (density gradient) rotors by use of live polio virus.


17-hydroxylation deficiency in man.

17-hydroxylation deficiency in man.


Use of zonal centrifuge to separate components of ribosomal RNA.


Rhinovirus infections in an industrial population. I. The occurrence of illness.


The enzymatic synthesis of a copolymer of 6-methyl deoxyadenylate and deoxythymidylate.


The DPNH-binding capacity of various dehydrogenases.


DPNH oscillations in a cell-free extract of S. carlsbergensis.


Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes.


On the regulatory properties of deoxycytidylate aminohydrolase.


A hydrophobic region at the active site of yeast alcohol dehydrogenase.


Some products of the degradation of blood group substances by alkaline borohydride.


Some observations on the elution of progesterone from silica gel.


Inhibition of thymidine kinase activity in liver and hepatomas by TTP and d-CTP.


Inhibition of ribosephosphate pyrophosphokinase activity by decoinine, an adenine nucleoside.


Transfer of H from succinate to DPN catalyzed by the Slater-Keilin-Hartree preparation.


A protein factor required for phosphorylation coupled to electron flow between reduced coenzyme Q and cytochrome c in the electron transfer chain.


Selective inhibition by deoxyglucosyl thymine of thymidine phosphorylases not catalyzing deoxyribosyl transfer.


Cimulative hemagglutination by Mycoplasma pneumoniae and other agglutinins. John, T. Jacob (University of Colorado School of Medicine, Denver), Marlene Stahl, and Vincent A. Fulginiti. Cumulative hemagglutination by Mycoplasma pneumoniae and other agglutinins. J. Bacteriol. 92:1002-1004. 1966.-The phenomenon of cumulative hemagglutination, or hemagglutination by two agglutinins, each in subagglutinating concentration, was demonstrated by use of four different systems, namely, horse serum and Mycoplasma pneumoniae, horse serum and measles antigen, M. pneumoniae and measles antigen, and parainfluenza 2 virus and M. pneumoniae. Cumulative hemagglutination appears to be the mechanism by which a horse-serum diluent causes high hemagglutination titers of M. pneumoniae, since both contain hemagglutinins against vervet erythrocytes. It was also shown that antibodies against either one of the two antigens may cause inhibition of such hemagglutination.


Quantitative aspects of inhibition of virus replication by interferon in chick embryo cell cultures. Hallum, J. V. (University of Pittsburgh, Pittsburgh, Pa.), and J. S. Youngner. Quantitative aspects of inhibition of virus replication by interferon in chick embryo cell cultures. J. Bacteriol. 92:1047-1050. 1966.-The effect of interferon on single cycles of replication of vesicular stomatitis virus and Mahoney poliovirus ribonucleic acid was studied in chick embryo cell cultures. The results showed that the titer of a given interferon preparation was independent of the input multiplicity of the challenge virus. In addition, the increase in virus yield with increasing virus challenge was a function of the number of infected cells, each of which yielded progeny at a level determined by the concentration of interferon to which the cells were exposed. These findings are not compatible with the concept that increases in the size of the virus challenge reverse or overcome protection of cells by interferon.


Effect of avian myeloblastosis virus in the Japanese quail. Moscovici, Carlo (University of Colorado Medical Center, Denver), and E. H. Macintyre. Effect of avian myeloblastosis virus in the Japanese quail. J. Bacteriol. 92:1141-1149. 1966.-Avian myeloblastosis virus (AMV) induced a spectrum of neoplasms in Japanese quail (Coturnix coturnix japonica) which was similar to that observed in the chicken, with one exception: the total absence of acute myeloblastic leukemia in quail. Studies in vivo as well as in vitro suggested that the cause for this difference may be ascribed to the heterogeneity of AMV and to the genetic makeup of the quail cell.


Control of dimorphism in Mucor rouxii.

Control of dimorphism in Mucor rouxii. Haidle, C. W. (The University of Texas, Austin), and R. Storck. Control of dimorphism in Mucor rouxii. J. Bacteriol. 92:1236-1244. 1966.-Yeastlike cells of Mucor rouxii NRRL 1894 were converted to filaments in a medium containing glucose, mineral salts, casein hydrolysate, nicotinic acid, and thiamine when the gas phase was changed from CO(2)-N(2) or N(2) alone to air. Germ tubes began to appear 3 to 4 hr after exposure to air. Ribonucleic acid (RNA) precursors were incorporated into RNA in a discontinuous fashion during this conversion, but the incorporation was continuous during the anaerobic growth of yeastlike cells and during the aerobic germination of sporangiospores. The incorporation of labeled amino acids during the conversion was exponential. Labeling of ribosomal RNA occurred as shortly as 5 min after replacement of CO(2)-N(2) with air. However, P(32)-labeled RNA isolated 20 min after exposure to air had a guanine plus cytosine (GC) content of 41% (mole%) as compared with the 47% found for labeled and unlabeled RNA isolated at other stages of the life cycle of this organism or later during the conversion. In addition, the overall base composition of this 20-min pulse-labeled RNA resembled that of deoxyribonucleic acid (GC = 39%), suggesting that a significant proportion of this RNA is of the messenger type. Furthermore, the synthesis of cytochrome oxidase was induced upon exposure of yeastlike cells to air. Cyanide, acriflavine, and cycloheximide, which inhibited the action or synthesis of cytochrome oxidase, also inhibited the yeast to filament transition.


Rapid disruption of intact yeasts by synthetic zeolite.


Neutralization of endotoxin toxicity in chick embryos by antibiotics. Rifkind, David (University of Colorado Medical Center, Denver), and John D. Palmer. Neutralization of endotoxin toxicity in chick embryos by antibiotics. J. Bacteriol. 92:815-819. 1966.-Three cationic cyclic polypeptide antibiotics, polymyxin B sulfate colistin sulfate, and tyrocidine hydrochloride, were shown to neutralize endotoxin lethality in chick embryos. The neutralizing potency of these antibiotics was approximately equivalent, 0.06 to 0.11 mumole of antibiotic per mug of endotoxin. Methane sulfonation of colistin resulted in a 13-fold decrease in endotoxin-neutralizing potency. Other cationic cyclic polypeptide antibiotics were inactive, as well all other classes of antibiotics tested, including the neutral cyclic polypeptides. Several nonantibiotic polycationic proteins and polymers tested were also inactive. It is suggested that certain cationic cyclic polypeptide antibiotics neutralize by combining directly with the toxic moiety of the endotoxin molecule. Possibly this combination involves the cationic groups of the antibiotics and the polyphosphate groups of the phospholipid component of endotoxin.


Characteristics of the photoreactivation of pseudorabies virus. Pfefferkorn, E. R. (Harvard Medical School, Boston, Mass.), Boyce W. Burge, and Helen M. Coady. Characteristics of the photoreactivation of pseudorabies virus. J. Bacteriol. 92:856-861. 1966.-Pseudorabies virus, killed with ultraviolet light and then allowed to adsorb to chick embryo tissue culture cells, can be photoreactivated by light of longer wavelengths. The photoreactivable sector is approximately 0.5. Herpes simplex virus is equally photoreactivable. Photoreactivability is negligible during the first 20 min after adsorption and then rises to a maximum by 100 min. After this maximum is reached, photoreactivability decreases with increasing rate as the temperature of incubation is raised. Inhibition of protein synthesis immediately after absorption prevents the establishment of the photoreactivable state.


Periodate inhibition of transformation and competence development in Haemophilus influenzae. Ranhand, Jon M. (University of Cincinnati, Cincinnati, Ohio), and Herman C. Lichstein. Periodate inhibition of transformation and competence development in Haemophilus influenzae. J. Bacteriol. 92:956-959. 1966.-Periodate treatment of competent cells reduced the frequency of transformation to streptomycin resistance about 90% while reducing cell viability about 30% or less. Moreover, when periodate was added to cells early in the competence-development phase, these, too, were unable to develop maximal competence. Periodate inhibition was dependent on time and concentration as well as on the composition of the suspending menstruum. Periodate had no effect on transforming deoxyribonucleic acid (DNA), nor did it prevent transformation when added to competent cells which had already reacted with DNA. Furthermore, the progeny from cells inactivated 90% could be made fully competent, showing that the inhibition was not genetic. It was concluded that the periodate-sensitive substrate may involve the DNA binding site(s).


Activity of mitomycin C, other antibiotics, and serum against lysogenic bacteria. Muschel, Louis H. (University of Minnesota, Minneapolis), and Karen Schmoker. Activity of mitomycin C, other antibiotics, and serum against lysogenic bacteria. J. Bacteriol. 92:967-971. 1966.-Lysogenic bacteria were found to be more sensitive to the bactericidal action of mitomycin C or streptonigrin than the corresponding sensitive or indicator strains. This result may be attributed to the induction of phage production in lysogenic cells by these antibiotics. Lysogenic and sensitive bacteria were, however, equally sensitive to chloramphenicol, streptomycin, and polymyxin B. In contrast to their greater sensitivity to certain phage-inducing antibiotics, the lysogenic state resulted in greater resistance to the bactericidal reaction of serum mediated by the complement system. In general, therefore, the lysogenic state may result in either decreased or increased sensitivity to various antimicrobial agents.


Mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity. Takemoto, K. K. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.), R. L. Kirschstein, and K. Habel. Mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity. J. Bacteriol. 92:990-994. 1966.-Three mutants of simian virus 40 were isolated on the basis of the type of plaques produced in primary cultures of African green monkey kidney cells and designated as L (large), S (small), and M (minute) strains. Significant differences in oncogenicity for hamsters were observed, with the 50% oncogenic dose being 10(4.5) for the L, 10(5.2) for the S, and 10(5.8) for the M strains. All three strains were capable of transforming human diploid cells (W138 strain). At temperatures up to 41 C, the S and M mutants were capable of multiplying to titers almost equivalent to those obtained at 37 C. In contrast, infectious virus was not produced when cells were infected with the L mutant and were incubated at temperatures above 39 C, although complement-fixing viral and tumor antigens were formed. The temperature-sensitive phase of replication of the L strain was shown to be a late stage in viral maturation or assembly.


Enzyme histochemistry of adenoid cystic carcinoma of minor salivary glands.


Granular cell myoblastoma of the tongue: report of case.


Pathophysiology of arteriovenous shunts in the extremities.


A study of the risk of mortality of varicella in patients with bronchial asthma or other allergic disease receiving corticosteroid therapy.


An unusual oral manifestation in a case of acute myeloid leukaemia.


Early changes in enzyme activity during the development of and recovery from vitamin D deficiency in the rat.


Using x-rays to establish the correct age of children. Value of this procedure with Israel's immigrant youngsters.


Presenting symptoms of neuroblastomas and Wilms' tumors.


Surgical lengthening of the external nose to correct congenital or traumatic arrest of nasal growth (an operation of value in treating nasal deformities of cleft lip and palate).


Mice and monkeys as assay animals for Clostridium perfringens food poisoning. Spores and vegetative cells of Clostridium perfringens, in combination with meat or starch paste, sterile culture filtrates, lecithinase, and phosphorylcholine, were administered to mice and rhesus monkeys in an attempt both to evaluate the animals as test agents and, if possible, to elucidate the active factors producing food-poisoning symptoms caused by this organsim. Some of the preparations were administered to the monkeys by stomach tube; others, in gelatin capsules which were treated with formaldehyde so that the release of their contents was delayed and presumably reached the intestines of the animals. Any changes in intestinal passage times and in consistency of stools of the animals were observed, and the counts of C. perfringens in the feces of the monkeys previous and subsequent to treatment were recorded. The results obtained were inconclusive. Diarrhea occurred only relatively infrequently in both species, regardless of the substance fed or the mode of administration. The changes in intestinal passage times were not great, although in the monkeys there appeared to be a slight trend toward reduction as the magnitude of the bacterial load increased. Phosphorylcholine appeared to have little, if any, effect in reducing intestinal passage time of mice or monkeys. No procedures explored in these experiments could be said to be satisfactory as a means of animal assay for food poisoning strains of C. perfringens since typical symptoms did not appear with regularity.


Antibody response of guinea pigs to trivalent parainfluenza virus vaccine prepared from embryonated eggs. A trivalent parainfluenza virus vaccine has been tested in guinea pigs. The parainfluenza 2 virus vaccine component was superior in the magnitude of antibody titers, and in the ability to convert animals serologically after two doses of an undiluted or a 10-fold diluted vaccine. The parainfluenza 1 virus vaccine gave a higher percentage of conversion than parainfluenza 3 virus vaccine after administration of two doses of either undiluted or 10-fold diluted vaccine.


Antagonistic effect on Clostridium botulinum type E by organisms resembling it. A bacteriocin-like substance, active against strains of Clostridium botulinum type E, is produced by certain nontoxic organisms whose biochemical properties and morphological characteristics are similar to type E. The substance, for which the name "boticin E" is proposed, is bacteriolytic for vegetative cells and bacteriostatic for spores of type E. Its spectrum of activity is somewhat strain-specific. Of the clostridial species tested, only C. botulinum type E and, to a lesser extent, C. perfringens and C. acetobutylicum, but not C. botulinum types A, B, or F, are sensitive. Irreversibly resistant variants originating from both vegetative cells and spores of certain strains were obtained. The active substance is heat-stable and dialyzable, and is not inactivated by chloroform but is digested by trypsin. Ethyl alcohol and acetone precipitates are fully active, whereas trichloroacetic acid precipitates are only partially active. Other nontoxic organisms producing similar antagonistic substances are discussed.


Technique for volume production of mouse ascites fluid containing Bordetella pertussis antibody.


Non-fatal mouse cytomegalovirus hepatitis. Combined morphologic, virologic and immunologic observations.


Acid phosphatase and lysosome activity in diphtheritic neuropathy and Wallerian degeneration.


The population-dependent requirement by cultured mammalian cells for metabolites which they can synthesize. II. Glutamic acid and glutamine; aspartic acid and asparagine.


"Communalities" in the ossification timing of the growing foot.


Resolution of the components in the microsomal fraction of liver in the B-IV zonal centrifuge.


Programming of poliovirus inhibition of deoxyribonucleic acid synthesis in HeLa cells. Ackermann, W. W. (The University of Michigan, Ann Arbor), and D. Wahl. Programming of poliovirus inhibition of deoxyribonucleic acid synthesis in HeLa cells. J. Bacteriol. 92:1051-1054. 1966.-Deletion of arginine from a culture medium reduced the rate of deoxyribonucleic acid (DNA) synthesis in uninfected HeLa cells. The normal rate was promptly restored by addition of arginine. Deletion of arginine also prevented poliovirus from inhibiting DNA synthesis in HeLa cells. However, the inhibitory potential of the infection and the capacity of the host cell for stimulation with regard to DNA synthesis were both retained in arginine-depleted cells which were infected. Upon addition of arginine late in the infection, DNA synthesis was first stimulated and then inhibited.


Colour, magnetic resonance and symmetry of the cupric site in blue protein.


Small-plaque and large-plaque variants of Papova virus SV-40.


Triglyceride accumulation in liver.

Triglyceride accumulation in liver.


Extragonadal estrogen production.

Extragonadal estrogen production.


Neurohumoral mediation of active reflex vasodilatation.


The rat adenohypophysis during increased corticotrophin production. A histologica and autoradiographic study using labelled nucleic acid precursors after adrenalectomy, after protracted stress and after adrenalectomy followed by cortisone administration.


Some aspects of urea and pyrimidine metabolism during development.


Central regulation of enzyme activity and synthesis in embryonal and adult mammalian tissues.


Overnutrition on resistance of dogs to distemper virus.


Jugular foramen and early roentgen diagnosis of glomus jugulare tumor.


Factors influencing the metabolism of brown adipose tissue in newborn mammals.


New and simple techniques for demonstration of the jugular foramen.


Intraduct papilloma of the breast.

Intraduct papilloma of the breast.


Characterization of a vascular permeability factor of renal origin.


Interference with feedback inhibition of adrenocorticotropin release by protein binding of corticosterone.


Observations on the production of hydrogen ions during mobilization of fatty acids from adipose tissue.


Isolation of a variant strain of foot-and-mouth disease virus (type O) during passage in partly immunized cattle.


The infectivity assay of foot-and-mouth disease virus in pigs.


Acquisition of Staphylococcus aureus by patients undergoing cytotoxic therapy in an ultra-clean isolation unit.


In vivo replacement of the helper virus in Bryan's strain of Rous sarcoma virus by AMV and RPL12 viruses.


Fluorescent antibody studies of viruses of the avian leukosis complex.


Biological studies on a leukemia virus extracted from C3H plasma cell tumor 70429.


The classification of malignant growths of the chorion.


Hypoglycemia in primary carcinoma of the liver. Report of a case.


Performance of papillary muscles isolated from cats in postoligemic shock.


Effect of cortisone on plasma iron concentration of normal and endotoxin-poisoned mice.


Effect of condensed phosphates on calcification of chick embryo femurs in tissue culture.


Actinomycin D effect on lag in vitamin D-mediated calcium absorption in the chick.


ACTH secretion after pituitary stalk section in the dog.


Hamartoma (leiomyomatous type) of the kidney.


The environment and problems in selection for disease resistance in the fowl.


Coxsackie group B virus infection and acute diarrhoea occurring among children in Costa Rica.


Lymphangiomyoma, a benign lesion of chyliferous lymphatics synonymous with lymphangiopericytoma.


Ultrastructure of nasopharyngeal angiofibromas.


Tryptophan metabolites in hypoglycemia associated with neoplasia.


The significance of endocrine activity in hypophysectomized diabetics.


Studies on the mechanims of oxidative phosphorylation. IX. Effect of cytochrome c on energy-linked processes.


Wilms' tumor: factors influencing long-term survival.


Age assessment in field surveys of children of the tropics.


Cortisol production rate. V. Congenital virilizing adrenal hyperplasia.


Sacrococcygeal teratoma in a newborn girl with massive intra-abdominal extension: combined abdominosacral approach.


The tautomerism of quinones and the question of quinone methide intermediates in oxidative phosphorylation.


Dihydroorotate dehydrogenase. 3. Interactions with substrates, inhibitors, artificial electron acceptors, and cytochrome c.


The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase.


Mechanism of the salicylate hydroxylase reaction.


Phosphoenolpyruvate carboxytransphosphorylase. II. Crystallization and properties.


The equilibria of reactions catalyzed by carboxytransphosphorylase, carboxykinase, and pyruvate carboxylase and the synthesis of phosphoendolpyruvate.


Some quantitative observations upon the oxidation of substrates of the tricarboxylic acid cycle in injured neurons.


Observations on the ganglion-stimulating action of angiotensin and bradykinin.


The protective effect of aldrin against the toxicity of organophosphate anticholinesterases.


Prevention and remission by adrenocortical steroids of nicotinamide deficiency disorders and of 6-aminonicotinamide toxicity in rats and dogs.


Biological activity of medrogestone: a new orally active progestin.


Clostridium perfringens; septicemia following perforation of a duodenal ulcer.


The Rauscher virus: a mixture of the Friend virus and of the mouse leukemia virus (Gross)?


The determination of molybdenum in natural waters, silicates and biological materials.


Hypernephroma and amyloidosis.

Hypernephroma and amyloidosis.


A practitioner's investigation of a possible outbreak of Blackleg.


Hormonal control of melanin pigmentation in scrotal skin of the rat.


Anaerobic bacteria in routine urine culture. One hundred and fifty-eight anaerobic organisms from 147 patients were isolated from 15,250 consecutive clean mid-stream or catheter urine specimens. The pathogenicity of the anaerobic genera commonly isolated from urine is reviewed and discussed. Failure to establish anaerobic isolates as pathogens and a paucity of reported cases proving anaerobic bacteria as significant causes of urinary tract infection permitted discontinuation of anaerobic culture as part of the routine screening procedure for investigation of urinary tract infections.


Light-induced alterations in melanoma-related free radicals, and the consequences on respiration and growth.


The end of the beginning.

The end of the beginning.


Measurement of renin and substrate concentrations in human serum.


Nursing with medicine.

Nursing with medicine.


H reflex study in upper motoneuron diseases.


Measurement of the pain threshold determined by electrical stimulation and its clinical application. II. Clinical application in neurological and neurosurgical patients.


Cytomegalic inclusion disease of infancy.


Arteriographic demonstration of pancreatic tumor in the Zollinger-Ellison syndrome.


Chemodectoma of the vagus nerve.

Chemodectoma of the vagus nerve.


The in vivo effect of quartz and carborundum dusts on the activity of cytochrome C oxidase and the DNA content of rat lung tissue.


Selective inhibition of poliovirus growth by d-Penicillamine in vitro.


Physiological characterization of heat-defective (temperature-sensitive) poliovirus mutants: preliminary classification.


Enhancement of the thymidine kinase activity of human embryonic kidney cells and newborn hamster kidney cells by infection with human adenovirus types 5 and 12.


Different transplantation antigens in BHK21 cells transformed by four strains of polyoma virus.


Induction of specific antitumor immunity in hamsters with hydroxylamine-inactivated SV40 virus.


Fetal ascites and cytomegalic inclusion disease.


Reconstitution of cytochrome c oxidase from an apo-enzyme and Cu (I).


Electron spin resonance spectra of spinach ferredoxin.


Phosphodiesterases active against glucose cyclic phosphates.


Inhibition of cyclic nucleotide phosphodiesterase by adenosine 5'triphosphate and inorganic pyrophosphate.


Glyconeogenesis of old diabetics.

Glyconeogenesis of old diabetics.


Adrenal failure complicating status asthmaticus in steroid-treated patients.


Dietary modifications of cold-induced metabolic effects.


Iodinated oil emulsion for lymphography.


Experience in the treatment of Crohn's disease of the large intestine.


Effect of normal and atheromatous aortic tissue on platelet aggregation in vitro. An investigation was made into the platelet-aggregating ability of human aortic tissue. It was found that potent aggregating substances are present in the vascular wall but that the degree and character of platelet aggregation produced was dependent on the method employed in the preparation of the tissue for study. The supernatants of aortic tissue homogenates were found to produce potent irreversible platelet aggregation that occurred after a latent period of one to two minutes. The activity was heat labile, destroyed by collagenase, sedimented by ultracentrifugation, and was considered to be identical or similar to collagen. An extract obtained by boiling aortic tissue with saline was found to cause less powerful reversible platelet aggregation that occurred within 15 to 30 seconds' contact with platelets; the activity was not affected by heating, incubation with collagenase, or ultracentrifugation, and was considered to be due to adenosine diphosphate. Atheromatous aortic tissue when extracted by either method was found to contain less than one half of the potency of normal tissue in causing platelet aggregation.


Preparation of phosphatidyl inositol from baker's yeast. Phosphatidyl inositol and a cardiolipin-like phospholipid survive the autolysis which is induced in yeast by treating it with toluene, whereas other phospholipids are extensively degraded. Lipid from autolyzed yeast was suspended in isopropanol to extract lecithin and neutral lipid. The insoluble phosphatidyl inositol and cardiolipin were then separated by chromatography on silicic acid.


Malignant hepatoma: repeated resection of metastases with survival for 15 years.


Pleomorphic adenoma of the palate. Report of a case.


Mucoepidermoid tumor of the maxilla. Report of a case.


The vulnerability of the posterior interosseous nerve of the forearm. A case report and an anatomical study.


Posterior interosseous nerve paralysis caused by a ganglion at the elbow.


Non-traumatic progressive paralysis of the posterior interosseous nerve.


The assay, extraction and storage of infective ribonucleic acid from foot and mouth disease virus.


Silica gel as a preserving agent for the cellular slime mold Acrasis rosea.


Malic dehydrogenase heterogeneity in malaria (Plasmodium lophurae and P. berghei).


Autoradiographic studies of H3-thymidine uptake in Entamoeba histolytica in CLG medium.


Histochemical studies on enzyme activities of gastric carcinoma. I. Hydrolytic enzymes.


Discrepancy of adrenal responses in diphenylhydantoin-treated rats.


The cytomegalic inclusion cell. An elctron microscopic study.


Electrodiagnosis of tarsal tunnel syndrome.


(K+)-dependent acyl phosphatase as part of the (na+ + K+)-dependent ATPase of cell membranes.


Oxalyl-coenzyme A synthetase from pea seeds.


Inability of rat-liver mitochondria to oxidize betaine aldehyde.


Cytochrome oxidase and its derivatives. V. The reaction of ferrous cytochrome c oxidase with oxygen and hydrogen peroxide in the presence of sodium dithionite.


On cytochrome c oxidase. I. The extinction coefficients of cytochrome a and cytochrome a3.


Purification of allergenic macromolecular compounds isolated from air-borne particles on thin-layer and preparative chromatography.


On cytochrome c oxidase. II. The ratio of cytochrome a to cytochrome a3.


The effect of digitonin on the respiratory chain enzymes of a heart-muscle preparation.


Kinetic studies on the mechanism of cytoplasmic L-alpha-glycerophosphate dehydrogenase of rabbit skeletal muscle.


Virus-specific RNA in cells productively infected or transformed by polyoma virus.


Sweating and glycogenolysis in the palmar eccrine sweat glands of the rhesus monkey.


Pituitary-adrenal function in the absence of vasopressin.


The effects of adrenalectomy and splenectomy on Trypanosoma lewisi infection in white rats.


Effect of caesarean-derivation, gnotobiote foster nursing and barrier maintenance of an inbred mouse colony on enzootic virus status.


Detection of ectromelia virus and ectromelia antibodies by immunofluorescence.


Cryosurgical treatment of juvenile laryngeal papillomatosis.


The association of indirect inguinal hernia with congenital cytomegalic inclusion disease.


Equine rhinopneumonitis virus as a cause of abortion in pregnant mares.


Histological lesions and virus isolation in rhinopneumonitis infection.


Virus infections of the human foetus.

Virus infections of the human foetus.


Lipogenesis in the hepatic tissue; lipogenesis and lipolysis in the adipose tissue of hyperglyceridemic and atherosclerotic patients.


Nature of anaemia in rheumatoid arthritis. VI. Metabolism of endogenous iron.


Pathogenesis and management of abdominal wall hematomas.


Fat metabolism in higher plants. 30. Enzymatic synthesis of ricinoleic acid by a microsomal preparation from developing Ricinus communis seeds.


Structure of the neutral trisaccharide of the chondroitin 4-sulfate-protein linkage region.


An autopsy case of renal disease similar to lipoid nephrosis modified by steroid treatment.


The influence of respiratory disease on the nasal carriage of staphylococci.


Histological studies of the monkey  neurovirulence of group B arboviruses. II. Selection of indicator centers.


Dual transfer of the posterior tibial  and flexor digitorum longus tendons for drop foot. Report of thirty-one cases.


Effect of age on the induction of glucose-6-phosphatase and fructose-1, 6-diphosphatase in rat liver.


Changes in adrenocortical function during aging in cattle.


Electron spin resonance technique for investigating reactions of free radicals with compounds of biological interest: nucleic acid constituents.


Physico-chemical properties of silica in relation to its toxicity.


Primary liver carcinoma in young men.

Primary liver carcinoma in young men.


Hemorrhage and pain from malignant hepatoma.


Fructose 1,6-diphosphate aldolase of Candida utilis: purification and properties.


Ubiquinone and menaquinone in bacteria: a comparative study of some bacterial respiratory systems.


Hydroxylation of deoxycorticosterone by Bacillus cereus, strain T.


Studies on the electron transfer system. LXVII. Polyacrylamide gel electrophoresis of the mitochondrial electron transfer complexes.


Purification and properties of fructose 1,6-diphosphatase from Polysphondylium pallidum.


Fructose diphosphatase from rabbit liver. V. Subunit structure of the purified enzyme.


The specific fructose diphosphatase of Escherichia coli: properties and partial purification.


Cytochrome c oxidase. 8. Lipid content.

Cytochrome c oxidase. 8. Lipid content.


Ultrastructure of a human hepatocellular carcinoma and surrounding non-neoplastic liver.


Clinical neuropathological conference.

Clinical neuropathological conference.


Experimental disciform keratitis. I. Immune response of the cornea to herpes simplex virus.


Phospholipids in human young placenta.

Phospholipids in human young placenta.


Purification and properties of whale pancreatic ribonucleases.


Studies on cell walls of Mycobacteria. I. Chemical and biological properties of the cell walls and the mucopeptide of BCG.


The presence of D-glucose 1,6-diphosphate hydrolyzing enzymes.


Studies on the mechanism of oxidative phosphorylation. X. The effect of cytochrome C on energy-linked processes in submitochondrial particles.


The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.


Effect of 6-methylthiouracil and thyroxin on deciduoma formation in ovariectomized rats.


The purification and properties of pig liver geranyl pyrophosphate synthetase.


Normotensive secondary hyperaldosteronism.


Effects of corticosteroids and ACTH on the hypophyseal-adrenocortical system.


Influence of glucose uptake by adipose tissue on its lipolytic activity during action of certain hormones and in experimental diabetes.


Characteristics of transplantable human embryonal cells transformed by simian virus 40.


The effect of insulin on enzyme adaptations to diets and hormones.


Intracystic carcinoma of the female breast.


Counter-current distribution of poliovirus type 2 and 3.


Enzymatic activities of Toxoplasma gondii.


Effect of silica on protein biosynthesis by rat liver cell-free systems.


Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail.


Electron microscopic observations on RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail.


Virus production in rat tumors induced by chicken sarcoma virus.


Factors in the causation of spontaneous hepatomas in mice.


Mechanisms for congenital transmission of avian leukosis virus.


Ocular involvement in congenital cytomegalic inclusion disease.


Selective and reversible inhibition of proliferation and influence on metabolic functions in L cells by low cortisol concentrations.


Antigenic analysis of tumors and sera from aimals inoculated with para-adenovirus populations.


Three outbreaks of foodborne disease with dual etiology.


Complement-fixing antibodies produced in guinea pigs immunized with purified N and H antigens of poliovirus.


Heat production in adipose tissue.

Heat production in adipose tissue.


The etiology and clinical course of bullous myringitis.


Effects of trypan blue on hepatocarcinogenesis in rats given ethionine or N-2-fluorenylacetamide.


Production of polyoma virus haemagglutination inhibitors in mouse kidney epithelial monolayers.


The corticotherapy in experimental trichinellosis.


The etiology of respiratory tract infections in military personnel. 6. A critical evaluation of a study during the years 1960-1963.


Diagnosis of asymptomatic meningococcal carriers by a selective medium.


Antagonistic effect on melanocyte-stimulating hormone release of two neural tissue extracts.


S-adenosylmethionine-synthesizing activity of normal and neoplastic mouse tissues.


Studies on the pathogenesis of plasma cell tumors. II. The role of mast cells and pituitary glycoprotein hormones in the inhibition of plasma cell tumorigenesis.


Activities of DNA nucleotidyltransferases and other enzymes in cell-free preparations from hepatomas of different growth rates.


Large head and acute brain syndrome in a 17-year-old, mentally defective female; a clinical pathologic conference.


The relationship between the vascular responses to the peptides angiotensin and pitressin.


The pressor response to noradrenaline and tyramine during angiotensin tachyphylaxis in the dog.


Osteonecrosis and sarcoma following external irradiation of intracerebral tumors.


Experimental study on alimentary infection with poliovirus and local immunity of intestines. I. Immunofluorescent study on the sites of primary multiplication of poliovirus following alimentary infection in monkeys.


Inheritance of susceptibility to Friend mouse leukemia virus. 3. Susceptibility of F1 and genotypes of F2 and backcross progeny.


Clostridium welchii infection in gastric surgery.


Viruses isolated from children with infectious hepatitis.


Management of withdrawal from alcohol (including delirium tremens).


Primary carcinoma of the liver (hepatoma). Its diagnosis by selective celiac arteriography.


Estrogen replacement therapy at menopause.


Estimation of left ventricular volume by one-plane cineangiography.


Sheltered boarding care: program coordination.


In-patient care in a comprehensive community mental health center.


Analysis of the Mellameter--a calibrated device for dispensing Mellaril concentrate.


Reaction of cobalt-chromium casting alloy with investment.


The role and the tasks of the Institute of Mental Health in Belgrade.


"Support"--its meaning for psychiatric nurses.


Relationship between physical contact and verbal interaction between nurses and patients.


Nurses--are they really wanted?

Nurses--are they really wanted?


Psychiatric drugs and trends: LSD.

Psychiatric drugs and trends: LSD.


Assessing the family's nursing needs.

Assessing the family's nursing needs.


A new embedding material in frozen tissue techniques.


Cystathioninuria.

Cystathioninuria.


S to N acetyl migration in yeast glyceraldehyde-3-phosphate dehydrogenase.


Initial myocardial succino-oxidase activity changes induced by intravenous infusion of Escherichia coli endotoxin in rabbit.


Peroneal palsy due to hematoma in the common peroneal nerve sheath after distal torsional fractures and inversion ankle sprains.


Cutaneous nephrogastric fistula: case report.


Adenocarcinoma of the renal pelvis.

Adenocarcinoma of the renal pelvis.


Subtotal pancreatectomy in the management of severe persistant idiopathic hypoglycemia in children.


Islet cell adenoma in childhood: report of a case.


Mutations, chromosomal aberrations, and tumors in insects treated with oncogenic virus. An increased incidence of lethal mutations, visible mutations, chromosomal losses, chromosomal nondisjunctions, and tumors resulted when drosophila were placed in medium containing Rous-sarcoma virus. In the group treated, a few mosaics of the eye and translocations appeared as well. There is a suggestion, from preliminary data, that the size of chromosomal puffs may be reduced by this RNA virus, but the difference is not significant. Tests for the persistence of virus in progeny have been negative so far.


Geriatrics.

Geriatrics.


A spectrophotometric method for the determination of microquantities of free inositol in biological material.


The "Commando-operation".

The "Commando-operation".


Cryosurgery of the head and neck.

Cryosurgery of the head and neck.


NADH-oxidizing activity of the labyrinthine fluids.


Effects of pituitary and adrenal tissue slices and hormones on the pigmentation of MM2 (melanotic melanoma) cells in tissue culture.


Hepatic embryonic mixed tumour in an adult.


The use of an accelerated adsorption method in a quantal estimation of the infectivity of Herpesvirus hominis.


Chemodectoma of the pineal region, with observations on the pineal body and chemoreceptor tissue.


Tumours in young chickens bred for rapid body growth (broiler chickens): a study of 351 cases.


The incidence of tumours in young chickens.


Thyroxin, satellite association and trisomy.


Rapid ascites tumour production.

Rapid ascites tumour production.


Isolation of a tumour virus from a chicken submitted to a poultry diagnostic laboratory--Esh sarcoma virus.


Adrenocortical function in alcoholics.

Adrenocortical function in alcoholics.


Glyoxylate reductase activity of lactate dehydrogenase.


A comparison of electroencephalography and brain scan in supratentorial tumors.


Binding of streptolysin S to red blood cell ghosts and ghost lipids.


Tumor extension from the glomeruli to the tubuli in experimental kidney metastasis.


Influence of dietary sodium on stimuli causing renin release.


Tricholemmoma of the scalp. Case report.


Anaesthesia for the surgical treatment of hyperinsulinism. Case reports.


Role of catecholamine release in cardiovascular responses to angiotensin.


Peripheral adrenergic basis for cardioaccelerator action of angiotensin.


Studies on adenovirus pneumonia in infants and young children.


Histochemistry and fine structure of 4-nitroquinoline-N-oxide-induced nuclear inclusions.


Studies on connective tissue tumors in the hamster produced by bovine papilloma virus.


Lack of secretion of serum protein by transplanted rat hepatomas.


The bacteriology of necrotizing jejunitis in Uganda.


Antitumor activity of periodate-oxidation products of carbohydrates and their derivatives.


Histogenesis of malignant neoplasm induced by adenovirus type 12.


Chromosomal alteration and the development of tumors. XII. Differentiation of karyotypes in mouse ascites hepatomas MH-134 and MH-129P maintained in different locations.


Biochemical changes in tumor cells caused by antitumor agents. I. Effects of several antitumor agents on NAD content and NAD-glycohydrolase activity in Yoshida sarcoma cells and rat liver.


Primary adenocarcinoma of renal pelvis (review of literature with first case report from India).


Mucus producing adenocarcinoma of renal pelvis (report of a case and review of the literature).


Mechanism of synthesis of deoxyribonucleic acid in vivo. The heterogeneity of incorporation of 32-P into the deoxyribonucleotidyl units in Escherichia coli.


Hepatoblastoma: report of a case.

Hepatoblastoma: report of a case.


Fructose diphosphatase from rabbit liver. 8. The involvement of tyrosine residues in the catalytic activity.


Effect of hypophysectomy on pyridine nucleotide metabolism. The role of nicotinamide.


Lipoamide dehydrogenase from human liver.


The enzymic synthesis of chorismic and prephenic acids from 3-enolpyruvylshikimic acid 5-phosphate.


An ultrastructural study of inter-specific cell fusion induced by inactivated Sendai virus.


Three angiotensin tests in the investigation of renal hypertension: bioassay, infusion, renogram.


Wilms tumors (nephroblastomas): report of 57 histologically proved cases.


Cytomegalic inclusion disease following multiple blood transfusions.


Renin-angiotensin system in normal and toxemic pregnancies. II. Inactivation of angiotensin in normal pregnancy.


Lack of feedback control of fatty acid synthesis in a transplantable hepatoma.


Studies on "nothing" dehydrogenase.

Studies on "nothing" dehydrogenase.


Parallel changes in vivo in microsomal inorganic pyrophosphatase, pyrophosphate-glucose phosphotransferase and glucose 6-phosphatase activities.


Studies on activities of gluconeogenic enzymes in sheep liver.


The role of free radicals of 4-hydroxy-3,5-diiodophenylpyruvic acid in the synthesis of thyroxine.


Hybridization of dwarf hamster cells by UV-inactivated Sendai virus.


Thermodynamic factors in the synthesis of two-stranded nucleic acids.


Inhibition of SV40 T antigen formation by interferon.


Hemorrhagic femoral neuropathy. Report of a case due to anticoagulant.


Chemical modification of the allosteric and catalytic sites of fructose 1,6-diphosphatase.


The size of the polypeptide precursor of collagen hydroxyproline.


Insulinoma and generalized islet cell hyperplasia in a patient with diabetes mellitus.


Different effects of chloramphenicol, dactinomycin, and streptovitacin A on synthesis of tumor and virion antigens in SV40 virus-infected cells.


Respiratory disease in a group of intensively reared calves.


Eosinopenia provoked by insulin in dogs in which the hypophysis has been substituted by transplants of salivary gland or adrenal tissue.


The reflex mechanism which controls the release of ACTH stored in the hypophysis.


Hemodynamics in acute renal failure. Pathogenesis of hyperkinetic circulation.


Rate of blood glucose fall as a determinant factor in insulin-induced adrenocortical stimulation.


Corticotrophs in the anterior pituitary glands of gonadectomized and thyroidectomized rats as revealed by electron microscopy.


Mechanism of the suppression by iodide of the thyroidal 131-I release rate in the rat.


Some effects of purified placental protein (human) on lipid and carbohydrate metabolism.


Sodium concentration and the effect of angiotensin II on ileal smooth muscle.


Relationship between the chemical structure of thiazolidine acetic acid derivatives and the antiherpetic activity in human embryonic cell cultures.


The sedimentation behavior of rhinovirus neutralizing activity in nasal secretion and serum following the rhinovirus common cold.


Inactivation and density studies with PARA-adenovirus 7 (SV40-adenovirus "hybrid" population).


Immunochemical studies of angiotensin.

Immunochemical studies of angiotensin.


Studies on Japanese B encephalitis virus vaccines from tissue culture. 8. Formalin inactivated OCT-wild strain vaccine.


Adrenal-mediated endometrial stimulation and withdrawal bleeding in the ovariectomized monkey.


Effect of choline salicylates and some other analogues of salicylic acid on the replication of EMC virus in vitro.


Vitamin D-actinomycin D interactions in bone. An electron microscopic study of hypertrophy and hyperinvolution of osteoblasts.


Differential blockade of deoxyribonucleic acid synthesis by ethionine.


Enzyme histochemical study on postmenopausal endometrium in symptom-free patients.


Late sequelae of radiotherapy for Wilms' tumour in infancy.


The role of polymorphonuclear leukocyte lysosomes in tissue injury, inflammation and hypersensitivity. IV. The inability of leukocyte lysosomes to alter native collagen fibrils.


The metabolism of cholest-5-en-3-beta, 7-alpha-diol by rat-liver cell fractions.


Urinary gonadotrophin excretion in patients with ulcerative colitis and Crohn's disease treated with A.C.T.H. and corticosteroids.


Glycine metabolism. 3. A flavin-linked dehydrogenase associated with the glycine cleavage system in Peptococcus glycinophilus.


Semiautomatic apparatus for milking mice.


Esterification of hydroxy compounds by fatty acid anhydrides.


Preparation of brain polyphosphoinositides.


Pathogenesis of virus-induced myeloid leukemia in mice.


Histologic measurements and fine structure of biopsied sural nerve: normal, and in peroneal muscular atrophy, hypertrophic neuropathy, and congenital sensory neuropathy.


Further observations on Paget's disease of the nipple.


Studies of adenovirus-SV40 hybrid viruses. V. Evidence for linkage between adenovirus and SV40 genetic materials.


The adrenal response of hamsters, gerbils and rats to exogenous corticotrophin or unilateral adrenalectomy.


Impairment of the pituitary-adrenal response to acute stress in alloxan diabetes.


Enzyme cytochemistry of iodine-131 irradiated thyroid gland.


Morphologic and biochemical effects of Clostridium perfringens alpha toxin on intact and isolated skeletal muscle mitochondria.


Ultrastructural studies on the lesion produced in skeletal muscle fibers by crude type A Clostridium perfringens toxin and its purified alpha fraction.


Deep lymphatic system of the lower extremity.


The association of acetyl-coenzyme A carboxylase with the microsomal fraction of pigeon liver.


Surgical results in patients with ulcerative colitis treated with and without corticosteroids.


Biochemical studies of the developing embryo. II. Studies on CO-2 fixation enzymes.


Electrophoresis of mammalian aldehyde dehydrogenase.


Association of a phaeochromocytoma and cerebral gliosarcoma with neurofibromatosis.


Digital vascular response to angiotensin II in normotensive and hypertensive subjects. Evidence for a qualitatively abnormal response to angiotensin in essential hypertension.


NADH-diaphorase activity in subcellular fractions of mouse tissues.


Growth hormone releasing action of a Pseudomonas endotoxin (piromen).


Radiological investigation of glomus jugulare tumours.


Chemodectomas of the carotid bifurcation.


Morphological changes of the brain following intrathecal application of contrast media.


Intestinal Clostridium perfringens in rheumatoid arthritis and other connective tissue disorders. Studies of fecal flora, serum antitoxin levels and skin hypersensitivity.


Dynamic investigation of urine, Na, K and Ca excretion after administration of tea, ACTH and ACTH with calcium in patients with articular disease.


Electron paramagnetic resonance and nuclear magnetic resonance as analytical tools.


Retinal changes in human cytomegalovirus infection. An electron microscopic study.


Traumatic hyphema: its clinical characteristics and failure of estrogens to alter its course. A double-blind study.


Choriocarcinoma in the Near East. Consanguinity as a possible etiologic factor.


Urine steroid excretion in postmenopausal cancer of the breast. Response to corticotropin stimulation and dexamethasone suppression.


Cytomegalic inclusion disease in childhood leukemia.


Treatment and prognosis in Wilms' tumor. A study of 51 cases with special reference to the role of actinomycin D.


Re-evaluation of the baroreceptor theory of control of renin secretion.


Some plant extracts and their anti-amoebic effect.


Measurement of platelet adhesiveness including the use of diatomaceous silica (celite). Methods of platelet adhesiveness to glass and celite have been developed. The technical merits of these methods have been compared with a method using adenosine diphosphate (ADP). The aspects of platelet stickiness measured by the various techniques may be somewhat different. Bearing this in mind, the reproducibility of the results using each of the three methods has been assessed on a series of healthy donors.


The use of some chlorinated hydrocarbon insecticides in central nervous system studies.


Studies of a myxovirus recovered from patients with infectious hepatitis. II. Fine structure and electron microscopic demonstration of intracytoplasmic internal component and viral filament formation. WB virus has been shown to have a fine structure which is characteristic of members of the mumps-NDV-parainfluenza group of viruses. Viral internal component has been demonstrated within the cytoplasm of infected cells. The incorporation of internal component into virus filaments at the cell surface has also been demonstrated. The evidence presented suggests that virus filament formation occurs by a process of invagination of the cell membrane about the coiled strands of internal component lying beneath the membrane.


Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis. By the use of radioautographic techniques it was shown that the lymphocytosis induced by Bordetella pertussis in mice was not caused by an increased production of lymphocytes but was primarily due to the entry into the circulation of mature cells from tissue pools. The accompanying polymorphonuclear leukocytosis was due to both proliferation of myeloid elements and entry of mature cells from tissue reserves, with the former the predominant mechanism.


Laryngotracheitis virus in chickens. A model for study of acute nonfatal desquamating rhinitis. Infectious laryngotracheitis can be produced in chickens as an experimental model of severe nonfatal rhinitis and sinusitis. Inoculated intranasally into unanesthetized baby chicks it remains limited to the nasal fossa, produces acute desquamation of all nasal epithelia, results in functional recovery of the respiratory epithelium, but leaves important residual abnormalities. From the earliest recognizable lesions through 4(1/2) months' convalescence, the principal changes are as follows: 1. Initial lesions, or small syncytia of intranuclear "inclusions", first identifiable in the mucociliated cells of the shallowest portion of the epithelium at about 21 hr postinoculum (the inner surface of the maxillary conchal scroll). 2. Acute sloughing, (about 3 to 7 days), marked by: (a) spread of lesions from cell to cell via multinucleated "giant cells" which progressively slough and desquamate respiratory, olfactory, and sinus epithelia, epithelial neural elements and blood vessels; (b) appearance of numbers of eosinophilic leukocytes along the basement membrane at the sites of lesions just previous to sloughing; intensive infiltration of the submucosa with small lymphocytes after sloughing begins; (c) histochemical change in the intracellular mucus of the cells which comprise the syncytia: this mucus stains with Alcian blue alone when stained with AB-PAS; and (d) all cartilages of the maxillary conchae become flaccid, and the cell nuclei and matrix lose both basophilic and Alcian blue staining properties, effects which recede by about the 8th day. 3. Repair (about 8 to 21 days), marked by rapid initial spread of a sheet of epithelial cells over the infiltrated subrmucosa, appearance of numbers of plasma cells circulating in the tissues, formation of encapsulated secondary nodules, and mucosal adhesions. 4. Convalescence (about 1 to 4(1/2) months when experiments terminated), marked by functional restoration of the mucociliary lining of the nasal fossa. However, at 4(1/2) months eight specimens all show complete metaplasia of the olfactory organ (end nerves, supporting cells, and glands of Bowman) to mucociliated epithelium, all show abnormal formation and alignment of mucous acini, and about 50% have severe persistent sinusitis.


Studies of the activity of diphtheria toxin. I. Poliovirus replication in intoxicated HeLa cells. It has been demonstrated that a saturating dose of diphtheria toxin produced a 90% inhibition of polio-virus replication in HeLa cells. This inhibition was reflected in infectious viral RNA synthesis and in mature virus production. Toxin had no direct effect on virus particles or I-RNA, and poliovirus adsorption and eclipse appeared to be carried out normally in intoxicated cells. When toxin was given at various time intervals after infection, the amount of inhibition depended on the time of toxin addition. Toxin given before or immediately after infection gave maximum inhibition, while toxin given several hours after infection had little effect. The data suggest that toxin inhibits viral replication through its effect on protein synthesis. It is likely that a critical step in the viral replication cycle, the production of poliovirus-induced RNA polymerase, is inhibited, and possibly the synthesis of capsid protein. Ammonium salts and the aliphatic amines, glycamine and prolamine, prevented the inhibition of viral replication by toxin. The kinetics of the protective action of ammonium chloride and diphtheria antitoxin are remarkably similar.


Persistent arteriovenous fistulae following chemotherapy of malignant trophoblastic disease.


Problems in the management of renovascular hypertension.


Siliceous urinary calculi in calves: prevention by addition of sodium chloride to the diet. Urinary calculi were found in all but one of 14 calves given a ration associated with the formation of siliceous calculi. No calculi were found in a similar group of 14 calves given the same ration with sodium chloride added (4 percent). It is suggested that sodium chloride prevented calculus formation by in creasing water intake and urine volume, with a consequent reduction in the con-centration of silicic acid in the urine


Oestrogens in congenital adrenal hyperplasia.


Pituitary-adrenal activation in rats with hereditary hypothalamic diabetes insipidus.


Ovarian endocrine activity in association with hormonally inactive neoplasia.


Effect of vaccination against bovine myxovirus parainfluenza-3 before weaning and at the time of weaning on the natural history of respiratory disease in beef calves.


Parainfluenza virus immunization. I. Antigenicity of two inactivated adjuvant parainfluenza type 3 vaccines.


On the theory of silicosis. II. Quartz glass.


Deficient red cell membrane /Na++K+/-ATPase in lead poisoning.


Pituitary adrenal function during corticosteroid withdrawal in rheumatoid arthritis.


Red cell membrane ATPase in workers exposed to inorganic lead.


Embryonic antigens in liver tumors in rats.


Studies on cellular resistance factors in polyoma virus infection.


Effect of desoxyribonucleic acid (DNA) on survival and rat liver injury after irradiation.


The effect of pure oxygen under different pressures in vivo on the anaerobic glycolysis of chrysoidine hepatoma in mice.


The influence of cellular immunity factors on oncogenesis in infection with polyoma virus in the Syrian hamster. Preliminary report.


The effect of interferon-like materials on the metabolism of mouse embryo cell cultures infected with polyoma virus.


The influence of the oncogenic polyoma virus on 2-phosphoenolpyruvate metabolism of mouse embryo cells grown in vitro.


Cytophotometric and cytochemical studies on the effect of actinomycin D and thioacetamide on rat liver cells.


Glucose induced hyperglycemia and hyperinsulinemia. Persistence following removal of an islet cell adenoma.


Histological studies on the cytomegalic inclusion body disease.


Histochemical studies of the carbohydrate metabolism of the subfornical organ in the rat.


Splenic pituitary homograft in the rat during gestation and lactation.


The "air bronchiologram" and the solitary pulmonary nodule. Report of a case.


Urinary pyrophosphate in normal subjects and in stone formers. The urinary excretion of inorganic pyrophosphate was determined in nine normal subjects and also in eight patients with recurrent calcium-containing renal stones during varied levels of phosphate intake. The excretion of pyrophosphate and orthophosphate is virtually the same in the two groups at all levels of phosphate intake. It appears unlikely that a consistently reduced urinary excretion of pyrophosphate is a factor in the formation of urinary calculi. Pyrophosphate excretion rose and calcium excretion fell with increasing phosphate intake; this might be expected to have a beneficial effect in patients with recurrent calcium stones.


Prolonged hyperadrenocorticotrophism and pigmentation associated with bronchial carcinoid tumour.


Periodic dialysis in terminal uremia.

Periodic dialysis in terminal uremia.


Radiation-induced free polydeoxyribonucleotides in lymphoid tissues: a product of the action of neutral deoxyribonuclease (DNase 1).


Mechanisms regulating adrenocortical secretion of aldosterone and glucocorticoids.


Differential renal function studies of the effects of angiotensin in normotensive and hypertensive patients.


Virucidal action of sea water.

Virucidal action of sea water.


Studies concerning the biological properties of zirconium silicate.


The significance of mumps hemagglutinin inhibition titers in normal populations.


Histochemical observations on hydrolytic and oxidative enzymes in tooth supporting tissues in mature rodents.


Thermal behaviour of silica and its application to dental investments. 1. A study of the polymorphic changes of silica.


The role of adenohypophysial hormones and their target glands in isoquinoline dye hepatocarcinogenesis.


The ultrastructural location of the periodate-Schiff reactive basement membrane at the dermoepidermal junctions of human scalp and monkey gingiva.


Glomus jugulare tumors. Methods and difficulties of diagnosis and surgical treatment.


The separation of infectious and autointerfering particles in vesicular stomatitis virus preparations.


A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus.


The effect of cytosine arabinoside on the replication of herpes simplex virus.


Intracellular crystals in FL cells infected with poliovirus.


On the apparent homology between DNA from polyoma virus and normal mouse synthetic RNA.


Nonhemagglutinating complement-fixing V antigen of parainfluenza 1 virus (HVJ). I. The production of nonhemagglutinating V antigen in chick embryos infected with HVJ.


The localization of SV40-induced neoantigen with ferritin-labeled antibody.


A soluble antigen of the mammary tumor virus.


Nonhemagglutinating complement-fixing V antigen of parainfluenza 1 virus (HVJ). II. The properties of nonhemagglutinating V antigen.


Significance of triiodothyronine for thyroid hormone supply during stimulation.


Viruses and oysters.

Viruses and oysters.


Pituitary-adrenal function in oral contraception.


Pituitary adenoma: results of combined surgical and radiotherapeutic treatment of 260 patients.


Selective lymphopenia in man after intralymphatic injection of radioactive 131-I lipiodol.


Metabolism of D-mannose in Aerobacter aerogenes: evidence for a cyclic pathway. Kamel, M. Y. (Michigan State University, East Lansing), and R. L. Anderson. Metabolism of d-mannose in Aerobacter aerogenes: evidence for a cyclic pathway. J. Bacteriol. 92:1689-1697. 1966.-Evidence is presented which suggests a cyclic pathway for the constitutive utilization of d-mannose in extracts of Aerobacter aerogenes PRL-R3. d-Mannose is phosphorylated with d-glucose-6-phosphate to yield d-mannose-6-phosphate and d-glucose. d-Glucose-6-phosphate may be regenerated by isomerization of d-mannose-6-phosphate through d-fructose-6-phosphate, or by phosphorylation of d-glucose with adenosine-5'-triphosphate. The pathway involves the participation of four constitutive enzymes: d-glucose-6-phosphate isomerase, d-mannose-6-phosphate isomerase, a stereospecific d-glucokinase, and a phosphotransferase which phosphorylates d-mannose with d-glucose-6-phosphate, acetyl phosphate, or carbamyl phosphate. The absence of d-mannokinase (adenosine-5'-triphosphate:d-mannose phosphotransferase) activity in extracts of this organism suggests that the pathway may be of functional significance. Also, the pathway accounts for an apparent 2-epimerization of d-mannose to d-glucose that was observed in extracts.


Enhancement of rhinovirus plaque formation in human heteroploid cell cultures by magnesium and calcium. Fiala, Milan (University of Washington, Seattle), and George E. Kenny. Enhancement of rhinovirus plaque formation in human heteroploid cell cultures by magnesium and calcium. J. Bacteriol. 92:1710-1715. 1966.-A reproducible macroplaque assay for six M and three H strains of rhinoviruses has been developed in several human heteroploid cell lines. Plaques were produced only with suitable solidifying agents: purified agar (Ionagar, Agarose) or methylcellulose. Plaque development was greatly enhanced by increasing Mg(+2) to 30 to 40 mm. Diethylaminoethyl (DEAE) dextran also increased plaque sizes, and the effects of Mg(+2) and DEAE dextran were additive. In addition, Ca(+2) substituted for Mg(+2). The suitability of human heteroploid cell lines for rhinovirus plaque assay varied greatly, ranging from insensitivity through partial to complete sensitivity. This assay was six to seven times more sensitive than an end point tube assay. These results indicate that potentiation of plaque formation by Mg(+2) known for some enteroviruses can also be extended to the rhinovirus group of picornaviruses.


Inhibition of Sindbis virus plaque formation by extracts of Escherichia coli. Vilcek, Jan (New York University School of Medicine, New York, N.Y.), and John H. Freer. Inhibition of Sindbis virus plaque formation by extracts of Escherichia coli. J. Bacteriol. 92:1716-1722. 1966.-Extracts prepared from washed cells of Escherichia coli B by sonic treatment and subsequent filtration through a 0.45-mu membrane filter significantly inhibited plaque formation with Sindbis virus in cultures or primary chick embryo cells up to a dilution of 1:20,000. The inhibitor acted on the cells rather than directly on the virus. The inhibiting substance was nondialyzable. Treatment of crude extracts with nucleases, trypsin, chymotrypsin, pepsin, or ether had no effect on the activity. Treatment with pronase destroyed the virus-inhibiting effect. Extracts prepared from two strains of E. coli B and one strain of E. coli K-12 all showed inhibitory activity against Sindbis virus. The inhibitor was present in the cytoplasmic fraction of bacteria. It was also active against Sindbis virus in human cells and showed some activity against vesicular stomatitis and vaccinia viruses in different types of cells. Interferon was not shown to be involved in the inhibition, although actinomycin D partially reversed the inhibitory activity of the extracts.


Persistent cyclic herpes simplex virus infection in vitro. IV. Changes in the severity of the infections in the presence of antibody. Hampar, Berge (National Institute of Dental Research, Bethesda, Md.). Persistent cyclic herpes simplex virus infection in vitro. IV. Changes in the severity of the infections in the presence of antibody. J. Bacteriol. 92:1741-1747. 1966.-The severity of persistent herpes simplex virus (HSV) infections maintained in the presence of viral antibody (AB) changed with time. These changes could be divided into three distinct phases during which the severity of the infections were maintained at low (phase 1), high (phase 2), and intermediate (phase 3) levels. Paralleling these changes was the appearance in the cultures of a new HSV variant which induced the formation of giant cells. The changes in the severity of the infections were attributable to three factors. The first was the presence in the cultures of virus-resistant cells. The second was the suppressive effects due to virus neutralization by the AB. The third was the inherent properties of each HSV variant which determined the amount of virus remaining in an infectious form in the presence of AB. Finally, the period of "exacerbation" in vitro (phase 2) was compared with recurrent episodes in human herpes infection.


Inhibitory effect of heparin on Rous sarcoma virus.


Electron microscopic observation of crystalline arrays of foot-and-mouth disease virus.


Zollinger-Ellison syndrome due to duodenal ectopic islet-cell tumour.


Papovavirus SV40, adenovirus and their hybrids: transformation, complementation, and transcapsidation.


Primary tumor of the glomus pulmonale producing pulmonary stenosis in a Boston terrier.


The effects of halothane on rat liver mitochondria.


Surgical treatment of hepatic tumors by hepatic lobectomy.


Structural relationships in the interaction of adrenocorticotropin with plasma proteins.


Synthesis of isoleucine-5-tyrosine-8-angiotensin II and isoleucine-5-hydroxyproline-7-angiotensin II.


Mossbauer spectroscopic evidence for low-spin iron in dehydrated metmyoglobin.


Computation of metal binding in bi-metal--bi-chelate systems.


Structure of amino acyl oligonucleotides from T-1 ribonuclease digests of soluble ribonucleic acid charged with serine, glycine, threonine, and alanine.


Two unusual tumours of the chemoreceptor system with angiographic demonstration.


Case reports. Glomus intravagale tumour.


Bone sclerosis in multiple myeloma.

Bone sclerosis in multiple myeloma.


The brain phosphoinositides.

The brain phosphoinositides.


Intraocular localization of copper by paramagnetic resonance spectroscopy.


Method of treatment of rheumatoid arthritis in different countries.


Kinetic constants of the human renin and human angiotensinogen reaction.


Prophylaxis of catheter-induced urinary tract infection in obstetric patients.


Liver protein synthesis after partial hepatectomy and acute stress.


Nucleoside triphosphate pyrophosphohydrolase of the plasma membrane of the liver cell.


Sialography: a useful aid in diagnosing parotid tumors.


Three cases of poliomyelitis in children with polio virus type I in the cerebrospinal fluid.


Stable cell line of rat nephroma in tissue culture.


Intra-renal distribution of glucose-6-phosphatase: methodological and physiological considerations.


Role of the pituitary and adrenals in cold and restraint induced liver nonprotein sulfhydryl depletion.


Enumeration of VSV particles and a demonstration of their growth kinetics by electron microscopy.


Mouse trophoblastic cells in tissue culture.


Biosynthesis of thiamine. Inhibition of thiamine phosphatase activity by pyridoxal.


The nature of antibody in swine naturally infected with japanese encephalitis virus.


A micro-method for assay of neutralizing antibodies against parainfluenza virus types 1 and 3.


Impaired development of rat liver enzyme activities at birth after irradiation in utero.


Simultaneous inhibitory action of virus multiplication of interferon and some natural mucopolysaccharides (heparin, hyaluronic acid).


Effect of heparin on herpes simplex virus infection in the rabbit.


Enhancing effect of human erythrocyte extracts on the susceptibility of monkey kidney cells to certain enteroviruses.


Studies on the initial phases of poliovirus reproduction cycle. II. Comparative studies on HeLa and permanent monkey kidney cells.


Thermal behaviour of silica and its application to dental investments.


Studies on the initial phases of poliovirus reproduction cycle. 3. Action of fatty acids and tween 80.


Radiological findings in acute necrotising encephalitis due to herpes simplex virus.


The nasopharyngeal angiofibroma.

The nasopharyngeal angiofibroma.


Hepatic tumours in childhood.

Hepatic tumours in childhood.


Hormonal control of rat testicular phospholipids.


Studies on hyperproteinemia and proteinuria in rats bearing a mammosomatotropic tumor.


Feedback mechanisms regulating pituitary ACTH secretion in rats bearing transplantable pituitary tumors.


Reaction of OH radicals with nucleic acid bases--an E.S.R. study.


Radical yields in some nucleic acid constituents.


Digestion of potato starch by larvae of the flour beetle, Tribolium castaneum.


Histidine in human vaginal fluid.

Histidine in human vaginal fluid.


Immunofluorescent and morphologic studies on swinepox.


Plasma corticosteroids in mice, with special regard to sex difference in adrenocortical responsiveness to exogenous corticotrophin.


Arteriography and chemotherapy in malignant trophoblastic disease.


Generalized herpes simplex in newborns.

Generalized herpes simplex in newborns.


Study of the cell bound inhibitor of polyoma virus haemagglutination.


The virus inactivating capacity of sea water.


Estrogen-induced arterial hypertension in the hibernating male toad, Bufo arenarum Hensel.


Inhibitory effect of heparin on herpes simplex virus. Nahmias, André J. (Boston University School of Medicine, Boston, Mass.), and Sidney Kibrick. Inhibitory effect of heparin on herpes simplex virus. J. Bacteriol. 87:1060-1066. 1964.-A substance inhibitory to herpes simplex virus was observed during experiments with leukocyte cultures. The component in the cultures responsible for this inhibition was identified as heparin. The minimal inhibitory concentration required to inhibit 30 to 300 tcd(50) of the virus in human amnion tissue culture was found to be 1 to 2 units per ml (10 to 20 mug/ml). This effect was confirmed with other strains of herpes simplex virus, other tissue-culture systems, and other media. The inhibitory activity of the heparin was found to be related to the sulfate groupings on the molecule. The effect of heparin appears to be on the virus, rather than on the cell. The virus is not inactivated, however, and the heparin-virus "complex" is readily dissociable on dilution. Heparin was shown to affect viral infection in its earliest phase, probably at the primary electrostatic attachment of virus to cell. The import of these and related observations on common virological laboratory procedures and the possible biological significance of our findings are discussed.


Metabolism of mannitol by Coccidioides immitis. Lones, George W. (National Institute of Allergy and Infectious Diseases, U.S. Public Health Service, Bethesda, Md.), and Carl Peacock. Metabolism of mannitol by Coccidioides immitis. J. Bacteriol. 87:1114-1117. 1964.-Strain M-11 of Coccidioides immitis was found to utilize mannitol for growth in the mycelial form but not in the spherule form. Cell-free extracts of both forms, grown on glucose, were capable of reducing nicotinamide adenine dinucleotide with mannitol-1-PO(4) but not with mannitol. The extracts accomplished a rapid oxidation of reduced nicotinamide adenine dinucleotide by fructose-6-PO(4), the expected product of mannitol-1-PO(4) oxidation. Fructose was inactive. Paper electrophoresis and chromatography with several solvent systems demonstrated a substance in extracts of both mycelium and spherules having a migration consistent with that of mannitol.


Mouse salivary gland virus plaque assay on a stable line of mouse embryo cells.


Heterogeneity of apparently complete poliovirus particles. Tumilowicz, Joseph J. (Children's Hospital of Philadelphia, Philadelphia, Pa.), and Klaus Hummeler. Heterogeneity of apparently complete poliovirus particles. J. Bacteriol. 87:1105-1113. 1964.-A chromatographic procedure was developed for separating the N from the H complement-fixing antigen of poliovirus. This procedure concomitantly effected some separation of classes of N particle. The ratio of physical virus particles (PVP) to plaque-forming units (PFU) in N-reactive fractions varied from 6 to 51. Fractions with the lowest PVP-PFU ratios represented a considerable enrichment of PFU, when compared with the original ratio in each experiment. A direct relationship was found between the ratio of complement-fixing units of N antigen [CFU(N)] to 10(10) PVP and the ratio of PFU to 10(10) PVP for most of the N-reactive fractions. Large differences among the PVP-CFU(N) ratios, along with relatively constant PFU-CFU(N) ratios for most of the N fractions, indicated that N antigen is not distributed equally among non-H particles. Two possibilities, both compatible with the results, were discussed for the manner in which N antigen might be distributed. An absolute value of 10(7) PVP-CFU(N) was proposed for particles with a PVP-PFU ratio of 1.


Polymyxin agar as an adjunct in the isolation of El Tor vibrios.


The metabolism of gamma-aminobutyric acid (GABA) in the lobster nervous system. II. Succinic semialdehyde dehydrogenase.


The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man.


The localization of placental enzymes with the electron microscope.


Evaluation of growth and of endocrine systems in testosterone-corticosteroid-treated patients with aplastic anemia.


Intrarenal hemodynamic changes following acute partial renal artery occlusion.


A comparison of skeletal growth and maturation in undernourished and well-nourished girls before and after menarche. A 25 year study comparing undernourished and well-nourished girls found that malnutrition delayed menarche and delayed, but did not stunt, skeletal growth.  The Birmingham, Alabama study followed 30 undernourished and well-nourished local white girls from approximately 4 - 19 years of age.  The well-nourished girls' diets met the US Daily Recommended Allowances but the other girls' diets were deficient in nutrients especially Vitamin A, ascorbic acid, iron, calcium and animal protein.  The girls' height was measured every 3 months, serial sequential roentgenograms were taken of their left hands and wrists every 6 months and the age of menarche of noted.  The undernourished group's rate of skeletal maturation was significantly slower premenstrually than the others and the occurrence of menarche was closely related to skeletal maturation.  Menarche was over 24 months later in the malnourished group at which time their skeletal maturation was similar to the group at the time of their menarche.  The postmenstrual rate of skeletal maturation of both groups was similar.  Asymmetry of maturation (the range from the most to the least advanced bones in an individual's hand) was higher in the undernourished group at the earliest age but declined in both groups with age.  The well-nourished group reached zero asymmetry at age 18; the malnourished group about two years later.  The mean height at maturity of both groups was not significantly different but the undernourished groups' greatest growth spurt was again 18-24 months behind the other group.


The metabolism of gamma-aminobutyric acid (GABA) in the lobster nervous system. I. GABA-glutamate transaminase.


Metastatic nephroblastoma of the mandible.


Diagnostic problems of choriocarcinoma and related trophoblastic neoplasms.


The galactose tolerance test as a measurement of the redox potential of the liver.


ACTH action on reductive pathway in the quartered rat adrenal.


Effect of a new hypotensive drug, ST155, on the systemic circulation.


Adjuvant therapy for advanced ovarian malignancy.


Red-cell metabolism in hereditary spherocytosis.


Malignancies in African children how do these differ from malignancies in the United States?


Ultrastructural localization of nucleoside triphosphatase in Langerhans cells.


Studies in the biochemistry of skin. IV. Some properties of mitochondria isolated from the epidermis of the adult rat.


Metabolic responses of white rats to balanced and imbalanced protein fed with different carbohydrates in 15 percent and 5 percent fat diets.


Reaction of infectious RNA with mammalian cells. I. Attachment to cells.


Growth rate and terminal cell density of bovine fibroblastic cells morphologically transformed in vitro by Rous sarcoma virus.


Evidence for early synthesis of Rous sarcoma virus in bovine fibroblasts.


Clonal analysis of bovine cells morphologically transformed in vitro by Rous sarcoma virus.


Kinetic and measurement of the renin-antirenin system.


Malignant anal lesions.

Malignant anal lesions.


Functioning metastases from an islet cell tumor of the pancreas.


Studies on circulation and elimination of viruses in the guinea pig.


Isolation and activity of propionin A, an antiviral polypeptide from Propionibacteria.


Children's age and stature estimated from femur diameter.


Local and systemic therapy of pseudomonas septicemia in burned mice.


Histochemical studies of enzymatic patterns during experimental carcinogenesis in the mouse parotid gland.


Screening data from the Cancer Chemotherapy National Service Center screening laboratories. XXXIX. Plant extracts.


A quantified periodic acid-Schiff reaction in normal and leukemic leukocytes.


Microangiopathic hemolytic anemia in carcinoma of the stomach.


Extraction and bioassay of renin from kidneys of sodium depleted and sodium-loaded rats.


Bilateral nephroblastoma in two sisters.


Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, Müllerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma.


Detroit 6 cells and infective hepatitis.


Cell culture and infectious hepatitis.

Cell culture and infectious hepatitis.


Effect of aldosterone and salt intake on renal and pressor actions of angiotensin.


"Spontaneous" changes in the brains of monkeys used for vaccine production.


Perianal skin amebiases.

Perianal skin amebiases.


A mechanical aid to control bladder infection and function using indwelling catheters.


Circadian pattern of plasma 17-hydroxycorticosteroid: alteration by anticholinergic agents. Atropine, administered to cats just prior to the time of the expected circadian rise in levels of 17-hydroxycorticosteroid in plasma, blocks this rise. Atropine does not alter this circadian pattern when administered at other times in the circadian cycle. Results similar to those obtained with atropine have been observed with short-acting barbiturates. Dibenzyline administered just prior to the time of the expected circadian rise is ineffective in blocking this rise. These findings support the hypothesis that the circadian pattern of plasma 17-hydroxycorticosteroid levels reflects activation, by the central nervous system, of the hypothalamicpituitary-adrenal axis during a "critical time period" in the circadian cycle.


Hydroxyquinone:NADH oxidoreductase from Aspergillus fumigatus. II. Kinetic studies on the enzyme.


Muscle-spindle histochemistry.

Muscle-spindle histochemistry. Reduced nicotinamide adenine dinucleotide tatrazolium reductase is abundant in cat intrafusal muscle fibers, whereas in the toad its activity is equal to that in extrafusal fibers. Spindles of both species contain little fat. In sections stained for adenosine triphosphatase bound to myofibrils, two types of intrafusal muscle fibers appear in spindles of both the cat and toad.


Hydroxyquinone:NADH oxidoreductase from Aspergillus fumigatus. I. Isolation and properties of the enzyme.


Immunization of guinea pigs with foot-and-mouth disease virus subjected to photodynamic inactivation.


Pharmacological control of lipid mobilization and transport.


Influence of drugs on vasoactive peptides and amines in perfused human placenta.


Influence of thyroid and adrenocorticotrophic hormones and of genetic factors on cholesterol metabolism in the rat.


Sites of avian leukosis virus multiplication in congenitally infected chickens.


Physiologic disposition and intracellular localization of isometamidium.


Nucleolar changes in KB tumor cells infected with herpes simplex virus.


Studies on composition and leakage of proteins and esterases of normal rat liver and Morris Hepatoma 5123 t.c.


Anogenital Paget's disease.

Anogenital Paget's disease.


The relation of various enzymes to cellular membranes.


Histochemical method for localization of cyclic 3',5'-nucleotide phosphodiesterase.


Cytochemical studies of hydrolytic and oxidative enzymes in sections and isolated cells from the endocrine pancreas of guinea-pigs.


Iodinated 5- and 8-hydroxyisoquinolines as potential amebicides.


Brain tumors with tuberous sclerosis.

Brain tumors with tuberous sclerosis.


The outside influence on patient care.

The outside influence on patient care.


The hormonal treatment of acroparaesthesia and night cramps.


A unique hyperfine ESR spectrum in mouse neoplasms analyzed by computer simulation.


Genomic modifications in cell line cultures chronically infected with a myxovirus.


Inhibition of viral replication by interferons with different molecular weights.


Susceptibility of HeLa cells in S-phase to inhibition of DNA synthesis by poliovirus infection.


Production of interferon in embryonated eggs and in cell cultures infected with simian virus 5.


Induction of interferon in mice infected with Toxoplasma gondii.


In vitro and in vivo antiviral action of an interferon-like substance induced by Toxoplasma gondii.


Ribonucleic acid of foot-and-mouth disease virus: an ultrasensitive plaque assay.


Effects of lanthanide chlorides on selected enzymes.


Cytomegalovirus infections with reference to isolations from lymph nodes and blood.


Hydroxylamine as a possible intermediate in nitrate reduction by Bacterium anitratum (B5W).


Production of varicella-zoster CF antigen in a continuous line of grivet monkey kidney cells.


Long-term cultivation of human and bovine fibroblastic cells morphologically transformed in vitro by Rous sarcoma virus.


Immunoelectrophoretic analysis of several strains of Entamoeba histolytica.


Infusion chemotherapy in hepatoma and metastatic liver tumors.


Ammonia production by the Bacterioides sp. used to support the propagation of Entamoeba histolytica in the CLG medium.


Effects of different species of bacteria on the pathology of enteric amebiasis in monocontaminated guinea pigs.


Studies on the anti-tumour activity of aliphatic aldehydes. I. The mechanism of inhibition of amino acid incorporation into protein of Yoshida  ascites hepatoma cells.


Peroneal-nerve irritation associated with cystic lateral meniscus of the knee. A report of two cases.


Hypophosphatasia in monozygotic twins. A case report.


Posterior interosseous nerve palsy due to rheumatoid arthritis.


Studies on the epidemiology of Escherichia coli infections. V. Factors influencing acquisition of specific serologic groups. Stool carrier rates of Escherichia coli serogroups 4, 6, and 75 were determined on admission and discharge for 190 patients. Persons who were in the hospital 3 weeks or longer had an intestinal carrier rate of 46% compared to a rate of 28% in individuals who had no recent hospital contact. Treatment with broad spectrum antibiotics increased the susceptibility for acquisition of certain specific serologic groups. This was apparently not related to replacement of sensitive E. coli by drug-resistant forms. Studies were made to determine the environmental source for colonization of hospitalized patients and the risk of urinary infection in stool carriers of these strains. A survey of inanimate objects of medical and urological wards demonstrated infrequent isolation of 04, 06, and 075, indicating that extraintestinal foci were an unlikely source for hospital-acquired E. coli. Hemagglutination titers with determination of group-specific O antibody failed to demonstrate any deficiency in hospitalized patients who became colonized with certain coliforms. Similarly, no significant deficit in group-specific serum antibody was found in patients who were community carriers of E. coli 04, 06, or 075. Despite a high rate of acquisition of E. coli serogroups 4, 6, and 75 in the stools of hospitalized patients, only those patients undergoing urinary tract manipulation developed bacteriuria.


ACTH antibodies in patients receiving depot porcine ACTH to hasten recovery from pituitary-adrenal suppression. Six patients who had experienced prolonged steroid-induced pituitary-adrenal suppression were treated with 100 U of depot procine ACTH every 2 to 4 days for several months. Such treatment did not hasten the recovery of normal pituitary-adrenal function compared with the rate of recovery of a group of similarly suppressed patients who received no depot ACTH. Eight of nine patients who received prolonged courses of depot porcine ACTH developed antibodies to ACTH that cross-reacted with endogenous ACTH, binding it in the circulation in inactive form and retarding its removal from the circulation. The presence of such antibodies did not in itself grossly alter pituitary-adrenal interrelationships.


The morphologic characteristics of 19S antibody.


The pathogenesis of Theiler's GD VII encephalomyelitis virus  infection in mice as studied by immunofluorescent technique and infectivity titrations.