Biochemical studies on inositol. IX. D-Inositol 1-phosphate as intermediate in the biosynthesis of inositol from glucose 6-phosphate, and characteristics of two reactions in this biosynthesis.


On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide.


An electron paramagnetic resonance study of 3,4-dihydroxyphenylethylamine beta-hydroxylase.


High molecular weight RNA from avian myeloblastosis virus.


Differences between the microsomes of normal rat liver and of N-2-fluorenylacetamide-induced rat hepatoma as determined by the paired label antibody technic.


Systematic oscillations in metabolic activity in rat liver and in hepatomas. I. Morris hepatoma No. 7793.


Metabolism of deoxyribonucleotides. II. Enzymatic phosphorylation of deoxycytidylic acid in normal rat liver and rat ascites hepatoma cells.


Factors controlling amino acid incorporation by ribosomes from krebs II mouse ascites-tumour cells. 1. A ribosome-cell sap system capable of supporting the incorporation of (14)C-labelled amino acids into protein has been prepared from Krebs II mouse ascites-tumour cells. The requirements of this system for optimum activity and response to added messenger RNA have been investigated. One such system has been obtained for which amino acid incorporation is almost wholly dependent on the addition of suitable messenger RNA. 2. Ribosomes of widely different but predictable activities in the cell-free system have been prepared from Krebs cells pretreated in a variety of ways. The factors in the pretreatment of the cells responsible for these differences have been investigated. 3. The structural and functional properties of these different ribosome preparations and their response to exogenous messenger RNA have been examined and are discussed in the light of modern concepts of the control of protein synthesis.


The effect of the chronic administration of barbitone sodium on  pituitary-adrenal function in the rat.


The route of ethanol formation in Zymomonas mobilis. 1. Enzymic evidence supporting the operation of the Entner-Doudoroff pathway in the anaerobic conversion of glucose into ethanol and carbon dioxide by Zymomonas mobilis is presented. 2. Cell extracts catalysed the formation of equimolar amounts of pyruvate and glyceraldehyde 3-phosphate from 6-phosphogluconate. Evidence that 3-deoxy-2-oxo-6-phosphogluconate is an intermediate in this conversion was obtained. 3. Cell extracts of the organism contained the following enzymes: glucose 6-phosphate dehydrogenase (active with NAD and NADP), ethanol dehydrogenase (active with NAD), glyceraldehyde 3-phosphate dehydrogenase (active with NAD), hexokinase, gluconokinase, glucose dehydrogenase and pyruvate decarboxylase. Extracts also catalysed the overall conversion of glycerate 3-phosphate into pyruvate in the presence of ADP. 4. Gluconate dehydrogenase, fructose 1,6-diphosphate aldolase and NAD-NADP transhydrogenase were not detected. 5. It is suggested that NAD is the physiological electron carrier in the balanced oxidation-reduction involved in ethanol formation.


Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids.


Studies on the electron transfer system. LXV. Formation of membranes by purified cytochrome oxidase.


Reversible inactivation of dehydrogenases.


Activation and inhibition in the phosphoglucomutase system.


The fixation of hydrocyanic acid by a psychrophilic basidiomycete.


Partial resolution of the enzymes catalyzing oxidative phosphorylation. XI. Stimulation of oxidative phosphorylation by coupling factors and oligomycin; inhibition by an antibody against coupling factor 1.


The effects of adenine nucleotides on carbohydrate metabolism in pigeon-liver homogenates. 1. The effects of added AMP on carbohydrate metabolism were investigated in pigeon-liver homogenates, which can degrade glucose and synthesize it from lactate. Suitable experimental conditions were established for studying such effects, including the addition of P(i) (20mm) to stabilize adenine nucleotides and supplementation with NAD(+) (0.5mm). 2. Lactate increased the rate of oxygen consumption and kept the concentration of ATP high and that of AMP relatively low. 3. Added AMP (1.25-5mm) raised the net rate of carbohydrate removal and inhibited the net formation of glucose from lactate, as well as the incorporation of lactate into glucose. These effects were accompanied by a fall in the concentrations of hexose 6-phosphates and a rise in those of fructose diphosphate and triose phosphates. When the activity of glyceraldehyde 3-phosphate dehydrogenase was limited experimentally by a low concentration of NAD(+) or when it was blocked by iodoacetate, the accumulations of fructose diphosphate and triose phosphates were large and accounted for most of the carbohydrate degraded in the presence of AMP. 4. AMP also inhibited the conversion of pyruvate into phosphoenolpyruvate. Data on the concentrations of pyruvate, phosphoenolpyruvate and intermediates of the tricarboxylic acid cycle, as well as on isotope distribution, suggest that the effect was due to inhibition of phosphoenolpyruvate carboxykinase. 5. The results indicate that in the homogenates phosphofructokinase and fructose diphosphatase, controlled in their activity by adenine nucleotides and other cell constituents, are enzymes which regulate the direction of carbohydrate metabolism (degradation or synthesis) in the liver. 6. It is suggested that active transport of adenine nucleotides, citrate, Mg(2+), Ca(2+), P(i) and other cell constituents may play a role in regulating the activity of enzymes which are affected by these substances. 7. A procedure is described for generating alkali in a closed manometer vessel, by mixing mercuric oxide and a solution of sodium iodide, for use in a method for measuring the oxygen consumption at physiological bicarbonate concentrations.


Activities of some enzymes concerned with citrate and glucose metabolism in transplanted rat hepatomas. 1. Certain enzymes concerned with citrate and glucose metabolism have been measured in two transplanted rat hepatomas, one induced with ethionine (minimal deviation type) and one induced with dimethylaminoazobenzene. In these hepatomas both citrate-cleavage enzyme and NADP-linked isocitrate dehydrogenase in the soluble fraction of the cell were approximately one-third of the values for normal rat liver. These changes have been discussed in relation to the increased citric acid content of tumours and depressed rate of fatty acid synthesis. 2. The glucose-ATP-phosphotransferase activity was below normal liver values in the ethionine-induced tumour but greater than normal in the dimethylaminoazobenzene-induced hepatoma. The apparent K(m) values for the glucose-ATP phosphotransferases of these hepatomas were approx. 8x10(-5)m; no evidence was found for an enzyme with a high K(m) for glucose equivalent to liver glucokinase. 3. Of the enzymes of the pentose phosphate pathway, glucose 6-phosphate-dehydrogenase activity was three to five times as great whereas 6-phosphogluconate-dehydrogenase activity was the same or lower than normal liver in the ethionine-and dimethylaminoazobenzene-induced tumours respectively.


An endonuclease from mitochondria of Neurospora crassa.


The structure of extracellular phosphorylated galactans from Sporobolomyces yeasts.


Wilm's tumour.

Wilm's tumour.


Antiviral agents. II. Substituted morpholinium quaternary salts.


Hypogammaglobulinemia with thymoma, hemolytic anemia, and disseminated infection with cytomegalovirus.


Nucleosides from homoribose.

Nucleosides from homoribose.


The UCLA interdepartmental conference. Opportunistic pulmonary infections.


Enzymic properties of subcellular phosphohydrolases in bovine brain cortex. Brain nucleotide phosphohydrolases.


Induction with nitrous acid of dextran sulfate resistance in type 1 poliovirus.


Characteristics of rapidly sedimenting ribonucleic acid from Harris strain Rous sarcoma virus and infected cells.


Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus.


Avian myeloblastosis virus (AMV) biosynthesis in chick embryo cells: studies of the particles released by trypsin from the infected cells.


Hamster tumor cells doubly transformed by SV40 and polyoma viruses.


Antigenic variation among polyoma viruses from different sources demonstrated by plaque neutralization.


Unstable DNA synthesized by polyoma virus-infected cells.


Clinical and steroid metabolic studies in four siblings with congenital virilizing adrenal hyperplasia.


Studies on the metabolism of C-21 steroids in the human foeto-placental unit. 2. Metabolism of pregnenolone sulphate by midterm placentas perfused in situ.


A novel rice-egg sandwich for mass propagation of Entamoeba histolytica on agar plates.


The recovery of a virus in experimental mouse LaH leukemia.


The inhibiting effect of thymectomy on the incidence of leukemia in rats inoculated by Mazurenko virus.


A contribution to the study on an experimental virus leukemia of CBA mice strain by the method of fluorescent antibody detection.


Chronic allergic neuropathy in the rabbit.


The chemistry of flavins and flavoproteins. II. Inhibition of the photoreduction of flavin nucleotides and analogues.


Charge-transfer complexes of nicotinamide-adenine dinucleotide analogues and flavin mononucleotide.


One-electron-transfer reactions in biochemical systems. I. Kinetic analysis of the oxidation-reduction equilibrium between quinol-quinone and ferro-ferricytochrome.


Effect of electrolytes on the paramagnetic susceptibility of ferriprotoporphyrin IX in solution.


Antibodies to DNA in mammals with Rous tumours.


An attempt at in vitro sensitization of immunologically competent cells against tumour specific antigen.


Relationship of Rous virus to guinea-pig and hamster cells in vitro.


Characterization of the products formed by the RNA polymerases of cells infected with encephalomyocarditis virus.


Corticotrophin-secreting carcinomas.

Corticotrophin-secreting carcinomas.


Cushing's syndrome: adrenocortical hyperactivity secondary to neoplasms arising outside the pituitary-adrenal system.


Liver response tests. VII. Coumarin metabolism in relation to the inhibition of rat-liver glucose 6-phosphatase.


A case of infectious bovine rhinotracheitis.


Phosphorus nuclear magnetic resonance study of phosphoproteins. I. Chemical nature of phosphorus atoms in bovine alpha-s-casein.


A theoretical study of hepatic glycogen metabolism.


The stereochemistry of the conversion of D and L 1,2-propanediols to propionaldehyde.


The release of enzymes by osmotic shock from Escherichia coli in exponential phase.


The inhibition by citrate of inorganic pyrophosphate-glucose phosphotransferase and glucose 6-phosphatase.


Biosynthesis of streptomycin. 3. Origin of the carbon atoms of streptose.


Reversibility of steroid delta-isomerase. 3. The soluble enzyme of Pseudomonas testosteroni.


The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. 3. The isolation and characterization of 3-deoxyoctulosonic acid.


A new intermediate in the biosynthesis of squalene.


Studies on cytochrome c peroxidase. VII. Electron paramagnetic resonance absorptions of the enzyme and complex ES in dissolved and crystalline forms.


Studies of myocardial oxidative enzymes during histaminic shock.


Physiological studies on trematodes: phosphatase systems in Gastrothylax crumenifer.


Anemia in rheumatoid arthritis.

Anemia in rheumatoid arthritis.


Metabolic inhibition of mammalian uridine diphosphate galactose 4-epimerase in cell cultures and in tumor cells.


Measurements of the human fetal ribs. Data about the determination of the body length and age based on the measurements of the ribs.


Further studies on the properties of liver propionyl coenzyme A holocarboxylase synthetase and the specificity of holocarboxylase formation.


Enzymes of nucleic acid metabolism from mung bean sprouts. I. Fractionation and concentration of phosphomonoesterase, ribonucleases M1 and M2, 3'-nucleotidase, and deoxyribonuclease.


The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini.


The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase.


Crystallization and properties of uridine diphosphate glucose pyrophosphorylase from liver.


Electron spin resonance studies of native and denatured methemoglobin. pH effects.


Cytochrome c peroxidase, a mitochondrial enzyme of yeast.


Trophoblastic tumors as they are in Japan. 2.


Studies on chemotherapy of trophoblastic tumors.


Serological comparison of selected parasitic and free-living amoebae in vitro, using diffusion-precipitation and fluorescent-antibody technics.


Immunological tolerance of neonatally infected mice to the Moloney leukaemia virus.


Threshold stimulation for nerve conduction studies in man.


The endocrinological aspects of benign intracranial hypeertension.


Rous tumors in monkeys.

Rous tumors in monkeys.


An experimental viral pneumonia in swine. Pneumonia resulted when a porcine entero-virus, ECPO-6, was inoculated intranasally into four and six week old, colostrum deprived, specific pathogen free piglets. Clinical signs consisted of mild depression, rapid breathing with rectal temperatures reaching 104-105 F five to six days after infection. Pneumonic lesions, both gross and microscopic were present 21 days post infection. Although the virus was readily isolated from the cecal contents of infected pigs three weeks after infection the virus was not recovered from infected lungs after the first 7-10 days.


Influence of epithelio-mesenchymal interactions on tumor induction by polyoma virus.


Decreased susceptibility to the mammary tumour agent in mice with advancing age. In mice, susceptibility to the mammary tumor agent (Bittner virus) decreases with advancing age.  With the newly developed technique of transplantation of the mammary gland and of complete extirpation of all mammary glands, the role of the host and of the mammary gland with regard to the decreased susceptibility towards the mammary tumor agent was investigated.  The experiments were done with female hybrids (female 020 x male DBAf)F1.  The susceptibility to the mammary tumor agent was determined by the percentage of mammary tumors which appeared in the transplanted glands.  Comparison was made between the tumor incidence in young mammary glands transplanted into both young and old hosts and in old mammary glands transplanted into young and old hosts.  Both the age of the host and the age of the mammary gland are determining factors in the development of mammary tumors.  With advancing age of the host and advancing age of the mammary gland, tumor incidence in the mammary gland decreases and the induction time is longer under otherwise equal conditions.  (author's)


Interrelationships of contacting cells in the cell complexes of mouse ascites hepatoma.


Demonstration of common specific antigen(s) in mouse and hamster polyoma tumors.


Studies on carcinogenesis by avian sarcoma viruses. 3. The differential effect of serum and polyanions on multiplication of uninfected and converted cells.


Formation of lung colonies by polyoma-transformed rat embryo cells.


Study of S91 mouse melanomas by electron paramagnetic resonance spectroscopy and tissue culture. I. The effect of cysteine on blue light signals and on growth in vitro.


Nonspecific life shortening in male mice exposed to the mammary tumor agent.


Production and susceptibility to interferon of polyoma virus variants of high and low oncogenic properties.


Body distribution of Lipiodol 131-J following intralymphatic radiotherapy.


The pathogenesis and pathology of infection in calves with a strain of bovine adenovirus type 3.


Further studies on the actions of peptides on the superior cervical ganglion and suprarenal medulla.


The urinary excretion of inorganic pyrophosphate by normal subjects and patients with renal calculus.


Respiratory virus antibodies in sera of persons living in isolated communities. It is known that young adults living in urban areas of many different parts of the world have serum antibodies against a number of viruses commonly associated with respiratory disease. It seemed possible that people living in isolated regions of the world, having infrequent contact with others, might have fewer virus infections, and, if so, that this would be reflected in an infrequent occurrence or low level of antibodies in their sera. Therefore sera were obtained from children and adults living in remote village-type communities in the Pacific (Micronesian islanders), North America (Eskimos) and South Africa (Hottentots). Antibodies against influenza viruses A2 and B, parainfluenza virus types 1, 2 and 3, reovirus types 1, 2 and 3, and two M rhinoviruses were present usually in a high proportion of sera in the three population groups; the results differed little from those for non-isolated communities. It seems that an extreme degree of isolation is required to reduce contact with viruses so that a population has little or no antibody.


Factors affecting the reversible dissociation of dehydrogenases.


The UV-induced triplet state in DNA.

The UV-induced triplet state in DNA.


The twisted circular form of polyoma viral DNA.


Electron spin resonance of an irradiated single crystal of thymidine.


Complement fixation and tissue culture assays for mouse leukemia viruses.


Studies on lipoamide dehydrogenase of bakers' yeast. V. The effects of metal ions and sulfhydryl reagents on the absorption spectrum of the enzyme.


Studies on brain phospholipids. IV. Post-mortem breakdown of phosphoinositides and phosphatidic acid, and P32-incorporation into phospholipids in various states of the tissue.


Kinetic studies on the oxidation and reduction of the protoheme moiety of yeast L(+)-lactate dehydrogenases.


Effects of digitonin and tocopherol on bovine heart muscle reduced diphosphopyridine nucleotide- and succinate-cytochrome c reductase and cytochrome c oxidase.


The angiotensin infusion test.

The angiotensin infusion test.


Mixed infections or contaminations of bovine viral diarrhea virus with infectious bovine rhinotracheitis virus.


Infectivity of three porcine polioencephalomyelitis viruses for germfree and pathogen-free pigs.


The effect of ultrasound on the gastric mucosa and its secretion of acid.


Coexisting bronchogenic carcinoma and tuberculosis.


Kinetic studies of adenine phosphoribosyltransferase.


Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.


A superhyperfine interaction involving 33-S in the iron-containing proteins of Azotobacter vinelandii.


Individual 17-ketosteroid excretion in a case of arrhenoblastoma and its response to corticotrophin and human chorionic gonadotrophin stimulation and to dexamethasone inhibition.


Variations of urinary antigens in trophoblastic proliferative disorders.


Report of a new long-acting (Zn) synthetic ACTH (CIBA 36716 Ba-24 corticotrophin) on adrenal secretion in human subjects.


Delayed hypersensitivity to herpes simplex virus in the guinea pig.


Distribution of the intestinal factor of normal mice which inactivates murine virus hepatitis.


Inhibition of transplantable and spontaneous murine tumours by the M-P virus.


Hyperlipaemia following viral infection in the chicken embryo: a new syndrome.


Recurrent pancreatic adenomas.

Recurrent pancreatic adenomas.


The results of hepatic lobectomy for primary carcinoma of the liver.


Survival of dogs treated with hyperbaric oxygen following hepatic artery ligation.


HPO in clostridial toxicity and strangulation obstruction.


Primary cancer of the liver in childhood.


Studies on the mechanism of action of colistin. IV. Activation of "latent" ribonuclease in Escherichia coli by colistin.


Transformation of duck embryo cells in vitro by avian tumour virus B77.


Further studies on the immunobiology of tumour RVA2 induced by RSV in C57BL strain mice.


Activation of deoxycytidylate deaminase from certain embryonal and tumour tissues by 6-aza-2'-deoxycytidine-5'-monophosphate and 2'-deoxycytidine-5'-triphosphate.


Denaturation of lactic dehydrogenase isozymes and its clinical application.


Isoprecipitin in the sera of rats resistant to tumour transplantation.


Stimulation of Sendai virus multiplication by puromycin and actinomycin D.


Hypothalamic regulation of ACTH secretion.


Protective performance of stannous fluoride--zirconium silicate prophylaxis pastes. SAM-TR-66-7.


Peristaltic reflex and hypotensive drugs.


Susceptibility of the steppe-lemming to the oncogenic action of Rous sarcoma virus.


Line of hamster cells transformed by the Schmidt-Ruppin strain of Rous virus in vitro.


Immunologically stimulated human peripheral blood lymphocytes in vitro. I. Morphological changes.


Determination of the 11-beta-hydroxylase activity in microgram samples of tissue; its quantitative histological distribution in the rat adrenal, and the influence of corticotrophin.


Hydroxylamine as an inactivating agent for foot-and-mouth disease virus.


Studies on Japanese B encephalitis virus vaccines from tissue culture. VI. Development of a hamster kidney tissue culture inactivated vaccine for man. 2. The characteristics of inactivation of an attenuated strain of OCT-541.


Studies on Japanese B encephalitis virus vaccines from tissue culture. VI. Development of a hamster kidney tissue culture inactivated vaccine for man. 3. Potency testing of an attenuated strain of OCT-541.


Range of heat resistance of Clostridium welchii associated with suspected food poisoning.


Interpretation of structural detail in viruses of the polyoma group.


Quantitative estimation of nuclear buds and micronuclei in bovine cells transformed by Rous sarcoma and SV 40 viruses.


Comparative absorption of calcium from calcium gluconate and calcium lactate in man.


Eosinophilic adenoma of the pituitary.

Eosinophilic adenoma of the pituitary.


Enzymic activities in Calvatia cyathiformis during and after meiosis.


Incidental finding of cytomegalovirus inclusions in cervical glands. A case report.


Glucose-6-phosphatase-like activity in the human placenta, fetal liver, and decidual tissue.


Pituitary enzymes. V. Proteolytic degradation of phosphohydrolase of 5'-mononucleotides from bovine pituitary gland (EC 3.1.3.5).


Body organ thermogenesis of the rat during exposure to cold and at maximal metabolic rate.


The response of colostrum-deprived, specific pathogen-free pigs to experimental infection with Teschen disease virus. The clinical response to Teschen disease and the excretion and rate of virus distribution in tissues of colostrum-deprived, specific pathogenfree pigs was determined. Severe, mild, and clinically inapparent responses to the disease were noticed following simultaneous intracranial and intranasal infections. Fourteen-day-old pigs reacted more severely to infection than 21-day-old pigs. The virus was detected in feces 2-3 days following infection but not in stools of surviving pigs 30 days after infection. The highest concentration of virus occurred during the incubation period and before onset of paralysis; the lowest concentrations were found during terminal disease stages. In tissues collected before or immediately after death of pigs, Teschen disease virus was found in several visceral organs but not in blood, urine or urinary bladder tissue. Virus yield was highest in brain and spinal cord tissues. Highest virus concentration was found in the cervical thoracic portions of the spinal cord, thalamus and cerebellum. Other aspects of the clinical disease are discussed.


Studies on the acetylcholine-stimulated incorporation of radioactive inorganic orthophosphate into the phospholipid of brain particulate preparations. II. Subcellular distribution of enzymic activity.


Adenoid cystic carcinoma (cylindroma) of the palate. Report of three cases.


Metabolic and physiological aspects of exercise at high altitude. II. Response of natives to different levels of workload breathing air and various oxygen mixtures.


Serological classification of swine enteroviruses.


Respiratory infections in children at a nursery in Finland. Virologic and epidemiologic studies over a 21-month period.


The appearance pattern of skeletal epiphyses among normal Finnish children during the first five years of life.


Actinomycin D inhibition of avian myeloblastosis virus production by chick-embryo fibroblasts.


Synthesis of dinucleotide anhydrides and ribonucleoside 3'-phosphate 5'-pyrophosphates.


Nicotinamide adenine dinucleotidase activity in experimental tuberculosis.


Potassium-ion stimulated p-nitrophenylphosphatase activity occurring in a highly specific adenosine triphosphatase preparation from rabbit brain.


Blepharoplasty following tumor surgery.

Blepharoplasty following tumor surgery.


Pyrophosphate and the mineralizing potential of urine.


Pressor effects of angiotensin infusions into different vascular beds in the rabbit.


Angiotensin blood levels in hypertensive and non-hypertensive diseases.


The effect of angiotensin on renal sodium excretion: studies in normal dogs and in dogs with experimental renal artery stenosis.


Adrenocorticotropins. XXXVI. Synthesis of a biologically active prolinol analog of the nonadecapeptide corresponding to the amino-terminal portion of the ACTH molecule.


Inactivation of foot-and-mouth disease virus by interaction of dye and visible light. The inactivation of foot-and-mouth disease virus was studied by means of the interaction of neutral red, Toluidine Blue, and methylene blue with visible light. The virus, Type A, strain 1, CANEFA of Argentine origin, was grown in tissue culture and tested in the crude and clarified state. Virus and dye were mixed and incubated together at 4 C for 45 min in the dark, or were mixed and immediately exposed to the visible light source without prior incubation together. Mixtures of crude virus and dye, under any of the experimental conditions used, did not inactivate more than 1 to 2 logs of viral infectivity when held in the dark or when exposed to light during a period of 45 min. Complete inactivation of virus was achieved when clarified virus and dye were mixed and immediately exposed to the visible light source for 15 min. Prior incubation of clarified virus and dye permitted inactivation by methylene blue only, whereas no incubation prior to exposure resulted in three of the dyes contributing to inactivation. A concentration of 6 mug of neutral red, Toluidine Blue, methylene blue, and crystal violet was used per milliliter of virus suspension. Crystal violet was not a good viral inactivator under the conditions of the experimentation. Inactive virus induced the formation of neutralizing antibodies in adult chickens and mice. The antibody titer stimulated by the antigen treated with methylene blue and visible light was probably significant.


Biochemical, histochemical and ultrastructural changes in the mouse seminal vesicle after castration.


Renin-angiotensin system in normal and toxemic pregnancies. I. Angiotensin infusion test.


Effect of several analogs of idoxuridine on the uptake of tritium-labeled thymidine in the rabbit cornea infected with herpes simplex.


The influence of p-fluoro-phenylalanine, puromycin, and actinomycin on the development of simian papovavirus (SV40).


The significance of roentgenological findings in the evaluation of maturity of the newborn. A clinico-radiological study of 486 newborns.


Radiation protection by sulphur in cyclohexane.


Heterogeneity of templae RNA in adrenal glands. Template RNA in adrenal glands appears to be heterogeneous in stability. The RNA that regulates synthesis of a large fraction of adrenal protein has a turnover time of 4 hours or less. The remainder of adrenal-protein synthesis, including synthesis of protein that mediates the rapid steroidogenic response to ACTH, depends on RNA with considerably greater stability.


Evaluation of steroid therapy for active carditis. Follow-up of 1 to 14 years.


Norepinephrine methylation in fetal rat adrenals. The activity of phenylethanolamine-N-methyl transferase, the enzyme that methylates norepinephrine to form epinephrine, increases rapidly in the fetal rat adrenal during the day preceding epinephrine accumulation. The developmental increase in enzyme activity and the accumulation of epinephrine are prevented by fetal hypophysectomy (decapitation). Administration of adrenocorticotrophic hormone or cortisol acetate largely reverses the effect of fetal decapitation.


Viral neoplastic transformation of hamster pineal cells in vitro: retention of enzymatic function. Cultures of hamster pineal tissue infected with certain oncogenic DNA viruses undergo neoplastic transformation and produce tumors when injected into homologous hosts. Hydroxyindole-O-methyl transferase, an enzyme found exclusively in the pineal gland, is present in low concentrations in transformed pineal cells in vitro and in larger amounts in tumors produced by the injected cells. This enzyme is not present in several nonpineal tissues similarly transformed.


Surgical prosthesis for reconstructive mandibular surgery.


The effect of hypothalamic implantation of 17-beta-oestradiol and systemic administration of prolactin (LTH) on sexual behaviour in male rabbits.


The laboratory diagnosis of whooping cough by fluorescent antibody and by culture methods. Attempts were made to hasten the identification of Bordetella pertussis by using the fluorescent antibody (FA) technique and to improve the isolation rate by culture methods. First, a comparison was made between the number of identifications of the organism by growth on Bordet-Gengou medium containing penicillin G and by staining smears of pharyngeal exudate with FA. Of 100 specimens, 29 were positive on culture and 46 were positive by the FA method. Five of the 46 were false positives. Second, 170 specimens were inoculated in quadruplicate on Bordet-Gengou medium containing either penicillin G or methicillin, and on Lacey medium containing either penicillin G or methicillin. In order there were 39, 41, 56 and 57 isolations. The isolation of Bord. pertussis on methicillin-containing media was easier than on penicillin-containing media. When culture and FA methods were compared, the most reliable was found to be the inoculation of specimens on Lacey medium.


Angiotensin tachyphylaxis and its reversal.


A sensitive method for assay of plasma renin activity.


Effect of hemorrhage on arterial plasma renin activity in the rabbit.


Clinical diagnosis of hepatoma.

Clinical diagnosis of hepatoma.


Growth of foot-and mouth disease virus in monolayer cultures of calf thyroid cells.


Electrophoretic separation of two plaque-type variants of encephalomyocarditis virus.


Labelling of corticotropin with iodine-125.


Radioisotopic scanning as an aid in planning radiation therapy.


Photochemistry of uridylyl-(3'--5')-uridine.


Infectious bovine rhinotracheitiis--sudden death in feedlot cattle.


Properties of motol virus in cultivation on tissue cultures and attempt at its identification.


Results of study of the antigenic properties of cell components of C1. perfringens by agar gel precipitation and immunoelectrophoresis. II. Results with the use of "monospecific" antitoxic sera.


The mechanism of the action of tetracycline antibiotics. 9. Inhibition of cytochrome oxidase by oxytetracycline.


Hemihepatectomy; a nursing care study.

Hemihepatectomy; a nursing care study.


Quantitative rhinovirus shedding patterns in volunteers.


Adenovirus soluble antigens for human immunization: a progress report.


Malic dehydrogenase activity in the preimplantation mouse embryo.


The effect of steroid hormones on lysosomal activity of rat ventral prostate gland in culture.


The production of embryous nodules in neonatal rats by the intravenous injection DNA from rat hepatoma.


Viraemia in haemorrhagic and other forms of smallpox.


Stevens-Johnson syndrome: nonspecific parasensitivity reaction?


Effect of single intravenous injections and intravenous instillations of norepinephrine and angiotensin on electrocardiographic patterns in dogs.


Ecthyma contagiosum (ORF).

Ecthyma contagiosum (ORF).


Effect of angiotensin on the cardiac arrhythmias induced by g-strophanthin.


Endocrinopathy associated with pancreatic carcinomas. Review of host factors including hyperplasia and gonadotropic activity.


Influence of thymic mass on murine viral leukaemogenesis.


Isolation and identification of poliovirus from a clinical specimen.


Electron microscopy of peripheral nerve terminals and marginal melanocytes in vitiligo.


Thiosemicarbazone derivatives in pox virus infections.


Asbestos--a hazard to the community.

Asbestos--a hazard to the community.


Ubiquinone in proline oxidation.

Ubiquinone in proline oxidation.


The effect of basic proteins on the oxidation of exogenous NADH2 in rat liver mitochondria.


Electron transport in Azotobacter vinelandii.


Phosphorylation associated with nitrate and nitrite reduction in Micrococcus denitrificans and Pseudomonas denitrificans.


Nicotinamide deamidase in Ehrlich ascites tumor cells.


NAD+-linked D-mannitol dehydrogenase in Acetobacter suboxydans.


On the role of amino groups in the structure and function of glutamate dehydrogenase. I. Effect of acetylation on catalytic and regulatory properties.


On the role of amino groups in the structure and function of glutamate dehydrogenase. II. Effect of acetylation on molecular properties.


Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide.


Enzymatic phosphorylation of fish phosvitin.


[Experimental studies on hepatitis epidemica. 3. Morphologic lesions in the spleens and lymph nodes of mice infected with the motol virus].


Transformation in vitro of mammalian cells by polyoma and Simian 40 viruses.


Histochemical and electron microscopic studies on the cells of the rat adrenal cortex in tissue culture.


Studies on the action of some enzymes on the cyst wall of isolated metacerkariae from the liver fluke, Fasciola hepatica L.


ACTH and adrenal hormones and catecholamine content of adrenal medulla, heart and brain.


Hyperinsulinism and islet cell tumor of the pancreas.


Mixed tumours of the parotid gland with metastases. (Case report).


Effect of estrogen administration on extravascular cortisol.


Plasma ACTH determinations in 58 patients before or after adrenalectomy for Cushing's syndrome.


Evaluation of testicular function by measurement of urinary excretion of testosterone.


Addition radicals formed by hydroxyl radical bombardment of uracil. Direct addition of O-H radicals at room temperature to the carbon No.5 of the uracil ring has been proved by measurement of the proton hyperfine structure in the electron spin resonance of the resulting uracil + O-H radicals. Upon addition of the OH, the H originally bound to carbon No. 5 shifts to No. 6, thus forming a methylene group at carbon No. 6, with the two protons having equivalent coupling of 28 gauss. The spin density on carbon No. 5 is O.64. The radicals were produced when powdered samples of uracil were subjected to a low-velocity beam of O-H radicals coming from either hydrogen peroxide or water vapor under reduced pressure and subjected to an electric discharge.


Spontaneous mammary tumors: decrease of incidence in mice infected with an enzyme-elevating virus. Mice infected with a virus which causes increased activity of lactate dehydrogenase, and of other enzymes in blood plasma, had a significantly lower incidence of spontaneous mammary carcinoma than did controls. When the experiment was terminated at 18 months, the incidence of mammary tumors in controls was 90 percent, and in infected mice, 53 percent.


Pituitary tumors in mice after prolonged feeding of synthetic progestins. An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.


Thyroid mitochondrial respiration.

Thyroid mitochondrial respiration.


Necrotizing enterocolitis: a report of six cases.


Bilateral carpal and tarsal tunnel syndrome.


Distribution of collagenase in rat tissues.


Effects of cyclic adenosine monophosphate and melanocyte-stimulating hormone on frog skin in vitro.


Mixed infection of African green monkey kidney cells by adenovirus 7 and SV 40.


Isolation of macronuclei from the ciliate Tetrahymena pyriformis GL.


Effect of corticosteroid hormones on rat-brain mitochondrial NADH-oxidase.


Differentiation of adrenal cortex-like tissue at the hilum of the gonads in response to adrenalectomy.


Reticuloendothelial activity and local particle disposal. A comparison of the influence of modifying agents.


Mucinous adenocarcinoma of the urachus.

Mucinous adenocarcinoma of the urachus.


Liver disease in the territory of Papua-New Guinea: a necropsy study.


On the mechanism of the potentiating of the angiotensin pressor effect by guanethidine and desmethylimipramine.


The effects of norepinephrine and angiotensine on the lymphatic system.


Effect of thymectomy on tumour production by polyoma virus in rabbits.


Increased cardiovascular reactivity to agiotensin caused by renin. After a short period of tachyphylaxis, there is a marked and sustained enhancement of pressor re sponses to renin and angiotensin during chronic administration of renin.


Hydrolysis of condensed phosphates in natural waters.


A comparison between virus isolations from sewage and from fecal specimens from patients.


The use of an aqueous polymer phase system for enterovirus isolations from sewage.


The role of nasal secretion and serum antibody in the rhinovirus common cold.


Complement fixation with tissue constituents in adenovirus pneumonia.


Studies on Japanese B encephalitis virus vaccine from tissue culture. VI. Development of a hamster kidney tissue culture inactivated vaccine for man. 4. Preparation and characterization of vaccine lot for human trial.


Bat salivary gland virus carrier state in a naturally infected Mexican freetail bat.


Angiotensinase in red cells.

Angiotensinase in red cells.


What brings on insulin sensitivity?

What brings on insulin sensitivity?


A granular cell myoblastoma of the larynx.


Effect of angiotensin on the pressor response to tyramine in normotensive subjects and hypertensive patients.


Extraction, purification, and assay of human renin free of angiotensinase.


Cytomegalovirus complement-fixing antibody in microcephaly.


The effects of alteration of blood-volume on the concentration of circulating angiotensin in anaesthetized dogs. 1. The blood-bathed organ technique was used to assay the concentration of angiotensin in the blood of anaesthetized dogs.2. Alterations of blood volume caused inverse changes of angiotensin concentration owing to changes in the rate of generation of angiotensin which are probably due to changes of the rate of renin secretion.3. Haemorrhage of 14-26 ml. blood/kg caused an increase of 0.25-1.5 mug/min in the rate of generation and an increase of 0.1-0.33 ng/ml. in the blood concentration of angiotensin.4. The changes of angiotensin generation rate were not due to changes of renal arterial or venous pressure. They were abolished by blocking the renal nerves with lignocaine; they showed a consistent inverse correlation with central venous pressure but not with systemic arterial pressure.5. It is concluded that changes of blood volume bring about changes of the rate of generation of angiotensin by a reflex mechanism the efferent limb of which involves the renal nerves. The afferent pathway remains to be elucidated, but the systemic baroceptors do not appear to be of primary importance.6. The renin-angiotensin system is important in the homeostatic response to changes of blood volume.


ACTH stimulation and dexamethasone inhibition in newcomers to high altitude.


Electron microscopic quantitation of viral particles in tissues of leukemic mice.


Implication of phospholipids in rat proximal tubule reabsorption.


Electrical stimulation and metabolism of a phosphoinositide complex in the salivary gland.


A micro method for performing parainfluenza virus neutralization tests.


Tissue culture characteristics and oncogenicity of three SV40-induced hamster tumors.


Postcolectomy syndrome with fever and abdominal pain simulating acute abdominal inflammation caused by steroid withdrawal.


Micro-neutralization test for identification of rhinovirus serotypes.


Relative effects of interferon on virus plaque formation.


Respiratory virus vaccines. IV. Heptavalent respiratory syncytial-parainfluenza-mycoplasma-influenza vaccine in institutionalized persons.


Early effects by SV40 on growth in vitro of hamster and human tissue cells.


Respiratory virus vaccines. V. Field evaluation for efficacy of heptavalent vaccine.


Studies on induction of virus from adenovirus and SV40 hamster tumors 2. "Helper" viruses.


Studies of a biochemical lesion in experimental tuberculosis in mice. IV. Effect of tubercle bacilli grown in vivo on respiratory chain enzymes.


Characterization of two newly recognized rhinovirus serotypes of human origin.


Virus particles in hamster tumors as revealed by electron microscopy.


In vitro effect of adrenocorticotropin on corticoid secretion in the turtle, snake, and bullfrog.


Endocrine control of freshwater tolerance in teleosts.


The effects of drugs on the relation between the action potential discharge and tension in a mammalian vein.


Free radical theory of aging: free radical reactions in serum.


Studies on induction of virus from adenovirus and SV40 hamster tumors 1. Chemical and physical agents.


Serological evidence of respiratory virus infections in Moscow children, 1948 to 1956.


Enzyme patterns in glycogen storage disease type II (Pompe's disease).


Demonstration of tissue receptors for viruses.


Identification of LSc2ab strain of type 1 poliovirus by inhibition with horse serum and dextran sulfate.


Effect of amygdaloid lesions on pituitary-adrenal axis in the deermouse.


Effectiveness of THAM in preventing cellular damage resulting from oxygen lack.


Renin, angiotensin and aldosterone in renovascular disorders.


Inorganic pyrophosphate: formation in bacterial photophosphorylation. Inorganic pyrophosphate is identified as the major product of photophosphorylation by isolated chromatophores from Rhodospirillum rubrum in the absence of added nucleotides.


Heat-labile serum factor required for immunofluorescence of polyoma tumor antigens. The immunofluorescent demonstration of polyoma tumor antigens in tumor cells requires a heatlabile serum component. With unheated hamster tumor serum, specific fluorescence was observed in polyoma-transformed hamster, mouse, and rat tumor cells. Heated serum usually gave little or no reactivity; the activity of such heated serum could be restored simply by the addition of fresh normal unheated hamster serum.


Hepatosplenomegaly after "cytomegalovirus mononucleosis" in a child.


Studies on the initial phases of poliovirus reproduction cycle.


Mixed malignant tumour in a digit of a dog.


Enumeration of Clostridium welchii in the faeces of varying sections of the human population.


Substrate specificity with palladium-on-silica gel catalysts.


Susceptibility of human diploid fibroblast strains to transformation by SV40 virus. A quantitative system has been developed for the study of transformation of human diploid fibroblasts in culture by two oncogenic viruses, SV40 and the E46 strain of adeno 7-SV40 "hybrid" virus. Seven of the eleven cell strains derived from human skin biopsies when infected with SV40 (10(9) tissue culture infective doses per milliliter) gave rise to transformed colonies with approximately the same frequency (0.03 percent). Two strains derived from patients with Fanconi's anemia, an autosomal recessive disease associated with a high incidence of chromosome abnormalities and spontaneous neoplasms, gave values more than ten times higher. Two strains from persons heterozygous for this gene were also considerably more susceptible to viral transformation.


The ecology and epidemiology of the pig-bel syndrome in man in New Guinea.


Dominant hemispherectomy: preliminary report on neuropsychological sequelae. The first reported case of continuing survival 6 months after left hemispherectomy for glioma in a right-handed adult shows diminishing psychological impairment. Different degrees of initial impairment and in subsequent recovery of propositional speech, verbal comprehension, reading, writing, and other functions indicate quantitative rather than-qualitative differences in adult left-and right-hemispheric functions.


Phosphatases in embryonic mouse cells in the course of infection with oncogenic polyoma virus.


Cytochemical studies in polyoma infection. I. The phosphatase group.


Periodate oxidation of the mucoid from horse erythrocytes.


Susceptibility of cultured renal cells from different species of subhuman primates to simian virus 40.


Chronic toxicity study in dogs following intralymphatic injections of ethiodol, ethiodol with chlorophyll and sterile non-iodinized poppy seed oil.


Transformation of renal cells from a prosimian by simian virus 40 (SV40).


Occurrence of SV40 neoplastic and antigenic information in vaccine strains of adenovirus type 3.


Chlordiazepoxide and diphenylhydantoin as antagonists to ACTH effect on serum calcium and citrate levels.


A high titered hemagglutinin in tissue culture prepared from Japanese B encephalitis virus.


Increased resistance to herpes simplex virus of hamster and human cells transformed by SV40.


Japanese B encephalitis virus vaccines from tissue culture. VII. Formalin inactivated Nakayama strain vaccine.


The "critical period" for production of humorally conditioned necroses.


Unique specificity of mouse angiotensinogen to homologous renin.


Susceptibility of cell lines of primate and nonprimate origin to certain human viruses.


Solid media with elemental sulphur for detection of sulphur-oxidizing microbes.


The effect of atherogenic diet and superinone on the activity of certain respiratory enzymes in the livers of pigeons and white rats.


Studies on the localization of heterologous antigenic organ and tumor extracts labelled with fluorescein isothiocyanate.


Hepatic NADH-diaphorase and mitochondria in experimental traumatic shock after intralienal injection of oxygen.


Central nervous system leukemia and solid tumors of childhood. Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU).


In vitro measurements of human tumor growth.


Chromosome constitution of nephroblastomas.


Malignant pericardial effusion secondary to metastatic breast carcinoma. A case of long-term remission.


Tumors of the glomus jugulare and glomus tympanicum.


Adenosine and the adenine nucleotides. Ionization, metal complex formation, and conformation in solution.


Chemical structure of circulin A.

Chemical structure of circulin A.


The effect of beryllium chloride on rat adenohypophysis.


Cytological and cytochemical studies on some organelles of the hepatic cells affected by severe intoxication with beryllium chloride.


Histochemical studies on the behaviour of insulin in secreting insulomas (nesidioblastomas) of the pancreas.


The relationship between ovarian tumours and intersex states with special reference to the disgerminoma and arrhenoblastoma.


Defective T particles of vesicular stomatitis virus. I. Preparation, morphology, and some biologic properties.


Defective T particles of vesicular stomatitis virus. II. Biologic role in homologous interference.


Replication of polyoma virus in mouse embryo cells: electron microscopic observations.


Rous sarcoma virus production from clones of nontransformed chick embryo fibroblasts.


Mixed clones produced following infection of chick embryo cell cultures with Rous sarcoma virus.


Structural changes associated with the release of enzymes from rat-liver mitochondria by freezing.


ACTH effect of pituitary glands of Pacific salmon demonstrated in the hypophysectomized Couesius plumbeus.


Critical periods in the organization of the nervous system. Role of the adrenal hormone.


Chronic pulmonary hemodynamic recordings in nonthoracotomized unanesthetized dogs.


Left-upper-quadrant mass following trauma.


Isolated deficiencies of anterior pituitary hormones. Symptoms and diagnosis.


Childhood malignant tumors. Concurrent chemotherapy with dactinomycin and vincristine sulfate.


Postural augmentation of plasma renin activity. Importance in diagnosis of renovascular hypertension.


Erythropoietin in children. I. Findings in various types of anemia.


Immunochemical studies on some serological cross-reactions in the Klebsiella group. 15. Further studies on the oxidized capsular polysaccharides as antigens.


Sex chromatin of trophoblastic tumors.

Sex chromatin of trophoblastic tumors.


Alterations in canine liver cells induced by protein deficiency. Ultrastructural and biochemical observations.


Validity of radiocarbon dates on bone.

Validity of radiocarbon dates on bone.


The continuous estimation of angiotensin formed in the circulation of the dog. 1. The use of the rat colon as a blood-bathed organ is described for detecting changes in angiotensin concentration in the circulating blood of dogs.2. Partial occlusion of the aorta by a balloon inflated above the renal arteries leads to a contraction of the blood-bathed rat colon.3. From the experimental evidence, it is concluded that this contraction is due to an increased concentration of circulating angiotensin, brought about by the liberation of renin from the kidneys.4. The characteristics of renin release have been studied. It occurs within seconds of reducing the blood pressure to the kidneys and is proportional to the degree of reduction of blood pressure.5. With a prolonged reduction of renal blood pressure the concentration of angiotensin increases over the first 10-12 min and then reaches a stable level.6. After a small haemorrhage angiotensin often appears in the circulation without a concomitant release of catechol amines.7. Greater haemorrhages induce the secretion of catechol amines as well as of renin. The catechol amine secretion is inhibited by ganglion block, but the renin secretion is not.8. It is concluded that the secretion of renin by the kidneys in response to a fall of renal blood pressure is a physiological response, probably of importance in homoeostasis.


Aldosterone secretion: differences in direct effects of rubidium and potassium perfusion into dog adrenals.


Leptomeningeal sarcomata and gliomata induced in rabbits by Rous sarcoma virus.


The possible involvement of an interfering substance in the action of thiosemicarbazones against viruses.


Studies on the differentiation of variola and vaccinia viruses.


Cytoenzymatic changes in the course of experimental osteomyelosclerosis in rats.


The cytologic and cytoenzymatic differentiation of idiopathic pancytopenias and preleukemic states.


Regulatory pattern of liver carbohydrate metabolizing enzymes: insulin as inducer of key glycolytic enzymes.


The reduction of nicotinamide N-oxide by xanthine oxidase.


Fetal-like patterns of lactic-dehydrogenase and aldolase isozymes in some pathological conditions.


The activation and inactivation of phosphorylase phosphatase from bovine adrenal cortex.


The action of hormones on juvenile nasopharyngeal angiofibroma. A case report.


The otoneurological diagnosis of intracranial expansive processes.


Brain aldehyde dehydrogenase. Localization, purification, and properties.


Evidence of nuclease activities associated with the preparations of virus BAI, strain A.


An examination of the cytotoxic effects of silica on macrophages. Effects of silica, diamond dust, and carrageenan on mouse macrophages were studied by phase-contrast cine-micrography, electron microscopy, histochemical techniques for lysosomal enzymes and measurements of the release of lysosomal enzymes into the culture medium. All added materials were rapidly taken up into phagosomes, to which lysosomes became attached. In all cases lysosomal enzymes were discharged into the phagosomes to form secondary lysosomes. Within 24 hr most of the silica particles and enzyme had escaped from the secondary lysosomes and lysosomal enzymes were found in the culture media. Most macrophages were killed by this time. With nontoxic particles (diamond dust, aluminium-coated silica, or silica in the presence of the protective agent polyvinyl-pyridine-N-oxide, PVPNO) ingested particles and lysosomal enzymes were retained within the secondary lysosomes for a much longer time, and cytotoxic effects were considerably delayed or absent altogether. It is concluded that silica particles are toxic because they are efficiently taken up by macrophages and can then react relatively rapidly with the membranes surrounding the secondary lysosomes. The particles and lytic enzymes can then escape into the cytoplasm, producing general damage, and thence into the culture medium. It is suggested that hydrogen bonding of silicic acid with lipid and protein constituents of the membrane accounts for the induced permeability. Protective agents such as PVPNO are retamed in lysosomes and preferentially form hydrogen bonds with silicic acid. Carrageenan is demonstrable within macrophages by its metachromatic reaction. It brings about release of enzymes from secondary lysosomes, but much more slowly than does silica. Silica released from killed macrophages is as cytotoxic as the original preparation. It is suggested that repeated cycles of macrophage killing in vivo leads to the mobilization of fibroblasts and fibrogenesis characterizing the disease silicosis.


Regulatory mechanisms connected with RNA synthesis in avian leukaemic myeloblasts. II. Changes in enzymatic activities splitting ribonucleoside 5'-triphosphates.


Vesicular stomatitis virus replication in human leukocyte cultures: enhancement by phytohemagglutinin. The replication of vesicular stomatitis virus in human leukocyte cultures shows that virus yields can be enhanced 6-to 180-fold by treating the leukocyte cultures with phytohemagglutinin prior to virus inoculation. Data suggest that a substance is produced in phytohemagglutinin-treated leukocyte cultures which is capable, on transfer to fresh leukocytes, of inducing blast cell formation and enhancing virus replication.


Intrathoracic neurogenic tumors.

Intrathoracic neurogenic tumors.


Countercurrent distribution combined with liquid scintillation counting of double-labeled water-soluble radioactive material in the study of the metabolism of steroid conjugates.


The postnatal pattern of growth at the sutures of the human skull. An histological survey.


Toxic effect of x-irradiated medium on chick embryo cells.


Bowel perforation. A complication of peritoneal dialysis using a permanent peritoneal cannula.


Unusual localization of mixed tumours in the parotid region.


Angiotensin infusion test in arterial hypertension.


New instruments for infectious laryngotracheitis vaccination.


Rate of protein biosynthesis in hepatoma 223.


Cytochemical localization of two glycolytic dehydrogenases in white skeletal muscle. The cytochemical localization, by conventional methods, of lactate and glyceraldehyde-3-phosphate dehydrogenases is limited, firstly, by the solubility of these enzymes in aqueous media and, secondly, by the dependence of the final electron flow from reduced nicotinamide-adenine dinucleotide (NADH) to the tetrazolium on tissue diaphorase activity: localization is therefore that of the diaphorase, which in rabbit adductor magnus is mitochondrial. NADH has been found to have great affinity to bind in the sarcoplasmic reticulum, and, therefore, if it is generated freely in the incubation media containing 2,2',5,5'-tetra-p-nitrophenyl-3,3'-(3,3'-dimethoxy-4,4'-phenylene)-ditetrazolium chloride (TNBT) and N-methyl phenazonium methyl sulfate (PMS), it can bind there and cause a false staining. Since such a production of NADH can readily occur in the incubation media for glycolytic dehydrogenases due to diffusion of these soluble enzymes from tissue sections, the prevention of enzyme solubilization is extremely important. Fixation in formaldehyde prevented such enzyme diffusion, while at the same time sufficient activity persisted to allow for adequate staining. The incubation media contained PMS, so that the staining system was largely independent of tissue diaphorase activity. Application of these methods to adductor magnus of rabbit revealed by light microscopy, for both enzymes, a fine network which was shown by electron microscopy to represent staining of the sarcoplasmic reticulum. Mitochondria also reacted. These findings add further support for the notion that the sarcoplasmic reticulum is probably involved in glycolytic activity.


Quantitative behavior of acidophilic leukocytes in capillary blood of children after adrenaline and ACTH administration.


Posterior rhizotomy: a possible substitute for cordotomy in otherwise intractable neuralgias of the trunk and extremities of nonmalignant origin.


Anterior pituitary function.

Anterior pituitary function.


13-C spin-rotation interaction and magnetic shielding at the carbon and oxygen nuclei in formaldehyde.


Immunologic reactivity of chickens harboring Rous sarcoma.


Electron spin resonance of met-myoglobin: field dependence of g.


Electron spin resonance of the excited triplet states of pyrimidines and purines.


Luminescence and electron spin resonance studies of adenine in various polynucleotides.


Phosphorescence and electron spin resonance studies of the uv-excited triplet state of DNA.


Multiplication of Rous sarcoma virus in mouse embryonal tissue.


Biochemical heterogeneity of brain mitochondria.


Respiratory virus vaccines. 3. Pentavalent respiratory syncytial-parainfluenza-mycoplasma pneumoniae vaccine.


Changes in activity of certain enzymes of carbohydrate metabolism in tissue cultures infected by viruses or their infectious RNA.


Correlation of liver cytochrome oxidase activity with mitochondrial cytochrome oxidase and phospholipid concentrations in protein-deficient rats.


Metabolism of cotisol-4-C in patients with infectious and collagen diseases.


Some histamine sensitizing properties of soluble preparations of the histamine sensitizing factor(HSF) from Bordetella pertussis.


Relationship of interferon-like inhbitor production to Rous sarcoma virus growth and tumor formation in chicks.


Neutralizing, hemagglutination-inhibiting and group complement-fixing antibody responses in human adenovirus infections.


Changes in the phosphatase activity of the spinal cord motoneurons and the spinal ganglion nerve cells following axotomy.


A histochemical study of lactic dehydrogenase in Paget cells.


Oxidation of thiocyanate, another index of thyroid function.


Hormonal regulation of rat kidney transamidinase; effect of growth hormone in the hypophysectomized rat.


Lipids of the BAI strain A avian tumor virus and of the myeloblast host cell.


Studies on the occurrence of common specific transplantation antigens in Rous tumors of various mammalian species.


Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.


The metabolism of isolated fat cells. IV. Regulation of release of protein by lipolytic hormones and insulin.


Studies on the biosynthesis of cholesterol. XX. Steric course of decarboxylation of 5-pyrophosphomevalonate and of the carbon to carbon bond formation in the biosynthesis of farnesyl pyrophosphate.


Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophosphohydrolase.


Phospholipid-metal complexes. Interaction of triphosphoinositide- and phosphatidylserine-metal complexes with ethylenediamine, polyaminoacids, and protein.


Experimental study on proliferation of Rous sarcoma cells and virus growth.


Viral neoplastic transformation of endocrine tissues in the newborn hamster.


The effect of heparin on aldosterone secretion and metabolism in primary aldosteronism.


Separation and characterisation of formaldehydrogenic delta-4-3-oxo-C21-steroids by means of thin-layer chromatography on silica gel.


Acquired immunologic tolerance and carcinogenesis by the mammary tumor virus.


Blood pressure response to the portal infusion of angiotensin-II.


Host response to homologous implantation of transformed cells.


Influence of corticotrophic hormone on the secretion of gastric mucus.


Heterologous transplantation of human glial tumors.


Role of the pituitary and kidney in the control of adrenocortical secretion during bleeding.


Observations on the origin of pregnancy-associated plasma proteins.


Possible adrenal origin of estrogens in the testicular feminization syndrome.


Histopathology and ultrastructure of an ovarian hilar cell tumor.


Effects of E. coli endotoxemia on ventricular performance.


Acute response in plasma renin and aldosterone secretion to diuretics.


Effect of glucocorticoids on metabolism of carbohydrate by kidney cortex.


Interactions between cytochrome system and H ion secretion in bullfrog gastric mucosa.


Anaerobic CO2 production by dog kidney in vitro.


The gangrene organism--a food-poisoning agent.


The periodic acid-Schiff reaction in neutrophil leukocytes--influence of fixation and amylase digestion. A quantitative microspectrophotometric study.


Survival of clostridium perfringens in starch pastes.


Metabolism of epitestosterone in man.

Metabolism of epitestosterone in man.


Glycogen synthesis from pyruvate in muscle.


Cardiac mitochondrial NADH2-cytochrome c reductase and cytochrome oxidase after cardiopulmonary by-pass in dog.


The effect of denervation on respiratory enzymes in the submaxillary gland of the rat.


Renal lesions induced by the simultaneous administration of angiotensin and hexadimethrine bromide.


The effect of corticotrophine on free fatty acid content in rat adrenal.


Neonatal herpes keratitis.

Neonatal herpes keratitis.


Mixed systemic virus infection: a postulate for alteration of host resistance to adenovirus infection.


Effect of ethanol on plasma corticosterone levels.


A relatively nonspecific supersensitivity in aortic strips resulting from pretreatment with reserpine.


Theophylline as a tool in studies of the role of cyclic adenosine 3',5'-monophosphate in hormone-induced lipolysis.


Establishment of four functional, clonal strains of animal cells in culture. The single-cell plating technique was used to develop four clonal cell lines that perform organ-specific functions after being serially cultured for prolonged periods. These strains include steroid-secreting Leydig cells, melanomacells that form pigment, and two strains from a hormone-secreting rat pituitary tumor. One of the cell lines from the pituitary tumor secretes growt hormone, while another line derived from the same tumor secretes a substance similar to adrenocorticotropic hormone.


Pulmonary blastoma, a form of carcinosarcoma. Report of a case of 24 years' duration without treatment.


Carcinoma in situ of the lung of peripheral (bronchiolar) origin.


Pathologic examination of specimens containing nonpalpable breast cancers discovered by radiography.


Histopathology of lymph nodes after lymphangiography.


Treatment of trophoblastic disease. With rationale for the use of adjunctive chemotherapy at the time of indicated operation.


Cryosurgical treatment of nasopharyngeal neoplasms.


Intermittent Cushing's syndrome with anomalous response to dexamethasone.


The relationships between electrical and mechanical events in rabbit aortic strips.


Centrally mediated cardiovascular effects of angiotensin II.


Effect of hydrazine on liver glycogen, arterial glucose, lactate, pyruvate and acid-base balance in the anesthetized dog.


The effect of hypophysectomy on canine pancreatic function.


Disparity between viral growth and cellular proliferation in the hen egg chorioallantois infected with a fresh isolate of herpes simplex virus.


The mechanism of host cell protein synthesis inhibition by poliovirus.


Patterns of viral interference in the avian leukosis and sarcoma complex.


Immunological relationships among envelope antigens of avian tumor viruses.


An electron microscopic study of moderate and virulent virus-cell interactions of the parainfluenza virus SV5.


Studies on foot-and-mouth disease virus ribonucleic acid synthesis.


Differential effects of nucleoside analogs on L-cell macromolecular synthesis and virus growth.


Studies of infantile diarrhea in Karachi, Pakistan. I. Collection, virus isolation and typing of viruses.


Venous intravasation of iodized oil during myelography. Report of a case with roentgenologic evidence of contrast medium in the iliac veins and in the lungs.


Angiographic findings in a patient with tuberous sclerosis.


Human trichinosis: report of four cases, with emphasis on central nervous system involvement, and a survey of 500 consecutive autopsies at the Ottawa Civic Hospital. In 1963, acute trichinosis was recognized in four patients at the Ottawa Civic Hospital. One presented with cavernous sinus thrombosis and sixth nerve palsy. A second had a severe systemic infection with myocarditis; the signs of myocarditis appeared in the third week. Electrocardiographic abnormalities included T-wave flattening, prolongation of PR interval and QRS complex, and non-specific changes in 25%. Central nervous system involvement occurred in the second week with general symptoms (headache, delirium and psychotic behaviour), followed in the third week by focal signs (nerve palsy, convulsion, pareses and coma).The incidence of trichinosis in the U.S.A. fell from 15.9% before 1948 to 4.5% in the period 1948-1963. The Canadian incidence in the period from 1940 to 1943 was 5.6%. In a survey in Ottawa using the Baermann digestion and compression methods, four positive cases were found out of 500 diaphragms examined. These figures indicate the success of the public health regulations aimed at controlling trichinosis. A gastrocnemius muscle biopsy is still an invaluable diagnostic tool, especially in critically ill patients with negative skin tests and no eosinophilia.


Effects of thiocyanate, perchlorate and other anions on thyroidal iodine metabolism.


Site of action of vasopressin in causing corticotropin release.


Analysis of adenohypophysial blood flow in the rat by radioisotope washout: estimate of the vasomotor activity of vasopressin in the anterior pituitary.


Histamine chromatography and electrophoresis. The omicron-phthalaldehyde fluorogram.


Effect of tannic acid on different viruses.


Studies on the conditions of interferon production by cells infected with herpesviruses.


The adsorption of metal ions on exchangers with phosphoric groups from perchloric acid solutions.


A new gas-liquid chromatographic phase.

A new gas-liquid chromatographic phase.


Thin-layer chromatography of substituted benzaldehyde 2,4-dinitrophenylhydrazones.


Quantitative determination of cholesterol in auto-oxidation mixtures by thin-layer chromatography.


Quantitative scanning of fluorescent or light-absorbing spots on thin-layer chromatograms.


Quantitative studies on isolated pancreatic islets of mammals: enzymic hydrolysis of nucleoside diphosphates and rho-nitrophenyl phosphate in normal and cortisone-treated rats.


Adaptation of variola virus to growth in the rabbit.


Antibody response in guinea-pigs following intranasal inoculation of respiratory syncytial virus.


Use of transplantation resistance phenomenon for comparative characterization of viruses of murine leusoces. I.


Adaptation to octamethyl pyrophosphoramide in rats.


Minor epileptic status.

Minor epileptic status.


New knowledge, new technology demand new practice.


Study of nurse activity after removal of management functions.


Insulin secreting islet cell tumors of the pancreas.


Motor nerve conduction velocity in chronic renal insufficiency.


Seclusion: a lesson for aides.

Seclusion: a lesson for aides.


Cultivating the virus of the variolovaccine in tissue culture of pancreas of Testudo graeca.


Camping experiences for psychiatric patients from a day care hospital.


Head nurse on a drug addiction ward.

Head nurse on a drug addiction ward.


Geriatrics.

Geriatrics.


The specific role of mitochondria in control of glycolysis during the development of fish embryo.


Cyclic appearance of a typical mitochondria containing DNA fibers in cultures of an adenovirus 12-induced hamster tumor.


Aging in retardation.

Aging in retardation.


II. Dandruff and seborrheic dermatitis.

II. Dandruff and seborrheic dermatitis.


The effect of x-irradiation on the nicotinamide adenine dinucleotides (NAD-NADH) content of rat thymocytes.


The psychiatric aide: his role and importance in a neurological (mental) hospital.


The training of nurses in psychiatry in Paris.


Stress ulcers complicating myocardial infarction.


Comparative effects of dihydrotachysterol-2 and dihydrotachysterol-3 in chicks.


Collagenase activity of immature Fasciola hepatica.


Early diffuse chromosome alterations in monkey kidney cells infected in vitro with herpes simplex virus.


Biophysical studies of a rhinovirus. Ultracentrifugation and electron microscopy.


Biophysical studies of a rhinovirus. Extraction and assay of infectious ribonucleic acid.


Antibody responses of young infants to naturally occurring viral infections.


Study on the effect of flavonoids and related substances. I. The effect of quercetin on different viruses.


Studies on the influence of endogenous regulatory factors on the growth of Herpes simplex virus.


Chromatography of poliovirus strains isolated in Hungary prior to and after the introduction of live poliovirus vaccine.


Chemical analysis of acid mucopolysaccharides of mixed salivary tumours.


The role of endolymphatic radiotherapy in the treatment of chronic lymphatic leukaemia.


Effects of vasomotor drugs and "mediators" of the inflammatory reaction upon the oxygen tension of tumours and tumour blood-flow.


Herpes gestationis. Report on 5 cases.

Herpes gestationis. Report on 5 cases.


Inflammatory changes in tumour vessels after systemic 5-hydroxytryptamine, bradykinin, kallikrein, or lysolecithin.


Localization of some enzymes in the iodonegative squamous-cell epithelium (negative Schiller area) of the cervix uteri.


Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses. Leukemias can be induced in W/Fu inbred rats by neonatal inoculation of normal thymus cells of C58 mice. These leukemias are not transplantable to C58 mice or to adult W/Fu rats, but they can be kept in passage in W/Fu rats aged 0 to 7 days. Adult W/Fu rats inoculated repeatedly with these isogenic leukemias produce cytotoxic and precipitating antibodies. These antisera are of particular value in the analysis of the antigens of leukemia cells and of leukemia viruses because their mode of preparation precludes the formation of antibody against any normal constituents of the cell. Analysis based on the cytotoxic test indicates the presence of 2 distinct cell surface antigens in leukemias induced by Passage A Gross virus or occurring spontaneously in mice of high-incidence strains. All leukemias and other tissues known to contain G (Gross) leukemia antigen have both determinants, but certain leukemias of low-incidence strains have only 1 of them and so were previously classified G-. Immunoprecipitation with these antisera reveals the presence of a cellular antigen common to G+ cells and absent from G- cells; the same antigen can be demonstrated in ether-treated Gross virus, but not in intact virus. This antigen is present also in ether-treated preparations of the Friend, Moloney, and Rauscher leukemia viruses, but not in Bittner (mammary tumor) virus. Thus it may be regarded as a group-specific antigen of murine leukemia viruses, in contrast to the type-specific cellular antigens demonstrable by the cytotoxic test. Four additional antigens associated with leukemias induced by wild-type Gross virus have been demonstrated by immunoprecipitation, but their relation to viral and cellular antigens has not been determined.


Studies in myasthenia gravis. Short-term massive corticotropin therapy.


Corticotropin in generalized myasthenia gravis. Effect of short, intensive courses.


A rational approach to corticosteroid therapy for asthma in children.


Investigations of enteroviruses in the aetiology of aseptic meningitis, poliomyelitis, encephalitis and other syndromes in Queensland, 1958 to 1962.


Disorders of the peripheral motor system.


Glomerular basement membrane in experimental nephrosis: chemical composition.


Radiological and microradiographic features in a case of congenital hypophosphatasia.


Metabolic requirements for infection by Rous sarcoma virus. I. The transient requirement for DNA synthesis.


The effect of ultraviolet light on the infectivity and enzyme-inducing capacity of papovavirus SV40.


Negative results. The urinary sodium-ACTH test for adrenal competence.


Nitrite reductase of Escherichia coli specific for reduced nicotinamide adenine dinucleotide. Kemp, John D. (University of California, Los Angeles), and Daniel E. Atkinson. Nitrite reductase of Escherichia coli specific for reduced nicotinamide adenine dinucleotide. J. Bacteriol. 92:628-634. 1966.-A nitrite reductase specific for reduced nicotinamide adenine dinucleotide (NADH(2)) appears to be responsible for in vivo nitrite reduction by Escherichia coli strain Bn. In extracts, the reduction product is ammonium, and the ratio of NADH(2) oxidized to nitrite reduced or to ammonium produced is 3. The Michaelis constant for nitrite is 10 mum. The enzyme is induced by nitrite, and the ability of intact cells to reduce nitrite parallels the level of NADH(2)-specific nitrite reductase activity demonstrable in cell-free preparations. Crude extracts of strain Bn will also reduce hydroxylamine, but not nitrate or sulfite, at the expense of NADH(2). Kinetic observations indicate that hydroxylamine and nitrite may both be reduced at the same active site. The high apparent Michaelis constant for hydroxylamine (1.5 mm), however, seems to exclude hydroxylamine as an intermediate in nitrite reduction. In vitro activity is enhanced by preincubation with nitrite, and decreased by preincubation with NADH(2).


Components required for the formation of CH-4 from methylcobalamin by extracts of Methanobacillus omelianskii. Wood, J. M. (University of Illinois, Urbana), and R. S. Wolfe. Components required for the formation of CH(4) from methylcobalamin by extracts of Methanobacillus omelianskii. J. Bacteriol. 92:696-700. 1966.-Optimal conditions for the formation of CH(4) from methylcobalamin (methyl-cobalt-5,6-dimethylbenzimidazolylcobamide) by partially purified extracts of Methanobacillus omelianskii (Methanobacterium omelianskii) were achieved by the addition of two protein fractions, adenosine triphosphate, Mg(++), and a reduced flavin adenine dinucleotide-generating system. Adenosine diphosphate and adenosine monophosphate play an important role in the regulation of C(1) transfer in this reaction. The possible position of adenosine triphosphate in B(12)-dependent methyl transfer is discussed.


Conversion of mevalonic acid to gamma, gamma-dimethylallyl pyrophosphate by Mycoplasma. Henrikson, Carl V. (University of South Dakota, Vermillion), and Paul F. Smith. Conversion of mevalonic acid to gamma,gamma-dimethylallyl pyrophosphate by Mycoplasma. J. Bacteriol. 92:701-706. 1966.-Three representative strains of Mycoplasma, M. laidlawii strain B, Mycoplasma sp. avian strain J, and M. hominis type 2 strain O7, were examined for the presence or absence of enzymes associated with the biosynthetic pathway from mevalonic acid to gamma,gamma-dimethylallyl pyrophosphate. M. laidlawii served as a control organism, since it is capable of de novo biosynthesis of carotenoids. All four enzymes, namely, adenosine triphosphate (ATP)-mevalonate 5-phosphotransferase (EC 2.7.1.36), ATP-5-phosphomevalonate phosphotransferase (EC 2.7.4.2), ATP-5-pyrophosphomevalonate carboxy-lyase (EC 4.1.1.33), and isopentenylpyrophosphate Delta(3),Delta(2)-isomerase (EC 5.3.3.2), were demonstrated in this organism. Mycoplasma sp. avian strain J, which contains all enzymes necessary for the biosynthesis of mevalonic acid, lacks the first three of the above enzymes but contains isopentenyl pyrophosphate Delta(3),Delta(2)-isomerase. M. hominis, which lacks the enzymes necessary for the biosynthesis of mevalonic acid, also is deficient in the enzymes involved in its conversion to gamma,gamma-dimethylallyl pyrophosphate.


Respiration of mengovirus-infected L-929 cells. Iglewski, W. J. (The Pennsylvania State University, University Park), and E. H. Ludwig. Respiration of mengovirus-infected L-929 cells. J. Bacteriol. 92:733-738. 1966.-Polarographic techniques were employed to study the oxidative metabolism of L-929 cells during a one-step mengovirus growth cycle. Virus maturation began 3.5 hr after infection and was complete with 7 hr. Virus maturation was accompanied by a decreased rate of endogenous respiration and an increased rate of oxidation of succinate and alpha-glycerophosphate by L-929 cells. The rate of glucose uptake was the same for mengovirus-infected and control L-929 cells. However, there was a decreased oxidation of glucose to carbon dioxide and a decreased production of lactic acid by L cells infected with mengovirus under aerobic conditions. Mengovirus was produced equally well under aerobic and anaerobic conditions. The implications of the alterations in metabolism with respect to virus synthesis are discussed.


Tumor immunity after viral oncolysis.

Tumor immunity after viral oncolysis.


Multiplication of polyoma virus. II. Source of constituents for viral deoxyribonucleic acid and protein synthesis.


Selective effect of pH on the production of exocellular protein by Clostridium perfringens type D.


Active immunization against infection caused by B virus (herpes-virus simiae). 3. Immunoprohylaxis of inhalation infection in rabbits.


Experimental infection of monkeys of the species Mac. rhesus with Pox-virus variolae and P. officinale after preimmunization with noninfectious antigen.


Determination of lactic and malic dehydrogenase activity in microorganisms by means of phenazine metosulphate.


Stability of the absorption patterns of poliovirus to calcium phosphate.


Demyelinating neuropathy in macrocryoglobulinemia.


The effects of angiotensin on renal vascularity in dogs.


Kinetocardiogram, phonocardiogram, and arterial pulse waves during acute hemodynamic changes.


Susceptibility of goats to infectious bovine rhinotracheitis.


Induction of multiple brain tumours (gliomata and leptomeningeal sarcomata) in dogs by Rous sarcoma virus.


On the role of the response of the cell membrane in determining virus virulence. Contrasting effects of the parainfluenza virus SV5 in two cell types. The simian myxovirus SV5 multiplies in a continuous line of baby hamster kidney (BHK21-F) cells causing extensive cell fusion, followed by cell death. After inoculation of 15 PFU/cell, the latent period was 7 hr, the doubling time approximately 60 min, and the yield 7 PFU per cell. Giant cell formation began about 6 hr after infection and rapidly progressed to the formation by 14 to 18 hr of a single syncytium which disintegrated by 24 to 36 hr. In contrast, SV5 multiplies in primary rhesus monkey kidney cells for long periods of time producing high yields of virus with little cytopathic effect. High multiplicities of SV5 induced cell fusion in BHK21-F cells within 1 hr in the absence of virus multiplication but had no visible effect on monkey kidney cells. Time-lapse photomicrography has demonstrated that giant cells form by fusion of infected cells, and that some polykaryocytes divide. During aberrant division of polykaryocytes giant nuclei are formed from the nuclear material of several parent nuclei. The cytoplasmic development of viral antigens as demonstrated by immunofluorescence is similar in BHK21-F and monkey kidney cells. Synthesis of cellular DNA, RNA, and protein in monkey kidney cells is not shut off by SV5-infection, and in BHK21-F cells synthesis of these macromolecules is not inhibited until after extensive cell fusion has occurred 12 to 15 hr after infection. Persistently infected BHK21-F and monkey kidney cells have been serially carried through 11 and 28 cell passages, respectively. The results suggest that whether SV5 acts as a moderate virus, as in monkey kidney cells, or a virulent virus, as in BHK21-F cells, depends on the response of the cell membrane to the virus.


Complex formation between transition metal ions and organic solvents: electron spin resonance investigations.


Effects of synthetic angiotensin on plasma free fatty acid and blood glucose-levels.


Action of Riley's enzyme-elevating virus on tumour-bearing mice.


Urinary 17-hydroxycorticosteroid excretion in guinea-pigs with hypothalamic lesions.


Analysis of urinary 17-ketosteroids by gas-liquid chromatography.


Determination of LDH isoenzymes.

Determination of LDH isoenzymes.


Pituitary-adrenal system in rats bearing lesions in the pituitary stalk.


Comparison of the responsiveness of perirenal adipose tissue of the rat, hamster, guinea pig and rabbit to the antilipolytic action of insulin.


Etiology and pathogenesis of acquired hemolytic anemia.


Control of epinephrine synthesis in the adrenal medulla by the adrenal cortex: hormonal specificity and dose-response characteristics.


Changes in adrenal corticosterone concentration in rats: method of bio-assay for ACTH.


Relationships between the structure and biological activities of corticotropin and related peptides: hyperglycemic action of N-acetylated corticotropin related peptides.


Action of ACTH upon steroidogenesis in the chicken-adrenal gland.


Effect of liver disease upon adrenocortical ACTH and metyrapone responsiveness in man.


Leiomyoblastoma of the stomach presenting as acute intraperitoneal hemorrhage.


The terminal nucleotidyltransferases of calf thymus nuclei.


An effect of puromycin on the synthesis of collagen by embryonic cartilage in vitro.


The pyridine nucleotide cycle and its role in the biosynthesis of ricinine by Ricinus communis L.


Studies on latent infection of skin and oral mucosa in individuals with recurrent herpes simplex.


Effect of morphine and nalorphine on the metabolism of phospholipids in guinea pig cerebral cortex slices.


Oncogenic properties of nucleic acid derived from SV-40 virus.


Four uncommon infections in Hodgkin's disease.


The effect of angiotensin II on adrenal steroid synthesis in the rat.


Effect of hormones on fatty acid release by rat adipose tissue in vivo.


Effect of temperature on synthesis of glycogen by diaphragm muscle in vitro.


Dissociation of the acute secretions of thyrotropin and adrenocorticotropin.


Structure and function in fructose diphosphatase.


Effect of anthrax toxin on oxidative metabolism of lung tissues.


Mycoplasma and adenovirus pneumonias. Comparison with other atypical pneumonias in a military population.


Extended study of Serratia in a diagnostic bacteriology laboratory.


Lymphatic cysts of the mesentery.

Lymphatic cysts of the mesentery.


Induction of dihydrofolate reductase activity by SV40 and polyoma virus.


DNA synthesis and neoplastic transformation in rat liver parenchyma.


Chemical, enzymatic, and cytochrome assays of microsomal fraction of hepatomas with different growth rates.


The metabolism of 4-nitroquinoline-1-oxide, a carcinogen. 3. An enzyme catalyzing the conversion of 4-nitroquinoline-1-oxide to 4-hydroxyaminoquinoline-1-oxide in rat liver and hepatomas.


Equine infectious anemia. New problems.

Equine infectious anemia. New problems.


Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus.


The introduction of anti-Rous sarcoma virus activity and chick embryo cell toxicity into human sera during processing.


Morphology and development of some murine leukemia viruses.


A virus-induced rhabdomyosarcoma of mice.


Tissue culture and serologic studies of mouse leukemia viruses.


Association of enzymes: adenosinetriphosphatase and alkaline phosphatase with the virions of murine leukemias.


Murine leukemia viruses: rupture with ether and detergents to subviral constituents.


Experiments on the hematologic diversification of viral mouse leukemias.


Studies on leukemia in mice associated with a transplantable methylcholanthrene-induced hepatoma.


Infective and noninfective viral murine leukemias.


Are the common forms of spontaneous and induced leukemia and lymphomas in mice caused by a single virus?


Murine leukemia and its viruses.

Murine leukemia and its viruses.


Serological analysis of leukemia antigens of the mouse.


Further studies on the biological relationship of murine leukemia viruses and on kidney lesions of mice with leukemia induced by these viruses.


Lymphoid tumor induction by mouse thymocytes infected in vitro with radiation leukemia virus.


Some experimental evidence for the influence of genetic factors on viral leukemogenesis.


The histocompatibility-2 locus and susceptibility to tumor induction.


Leukemia virus release in chemically or physically induced lymphomas in BALB-c mice.


Inhibition of virus-induced leukemia in mice by a nontumor virus.


Origin of the viremia in murine leukemia.


Masculinization in pregnancy. Report of a case.


ACTH and steroids: their use in the practice of allergy.


Odontodysplasia. Report of three cases.

Odontodysplasia. Report of three cases.


An analysis of SV40-induced transformation of hamster kidney tissue in vitro. 3. Persistence of SV40 viral genome in clones of transformed hamster cells.


Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. A father and son are described with a condition characterized by benign hypertension, potassium deficiency, increased aldosterone secretion rate (ASR), raised plasma volume and suppressed plasma renin activity (PRA). There were intermittent elevations of urine 17-ketosteroids and 17-hydroxycorticoids (17-OHCS) but no increase in urine THS, normal circadian rhythm of plasma 17-OHCS, and normal urine 17-OHCS response to dexamethasone and intravenous ACTH. Plasma ACTH and corticosterone secretion were not elevated. Pregnanetriol excretion was normal but urine pregnanediol was increased. At operation on the father no adrenal tumour was found; the excised left adrenal weighed 7 g. and showed nodular cortical hyperplasia; juxtaglomerular cells showed only occasional granules. Following operation hypertension persisted and ASR was half the preoperative value. All abnormalities in father and son were relieved by dexamethasone (DM) 2 mg. daily. The condition recurred following cessation of DM but was relieved by a second course of treatment. No such response to DM was seen in a normal subject or in a patient with Conn's syndrome. For a number of reasons it is suggested that patients with hypertension, increased ASR and low PRA be given a trial of dexamethasone treatment before undergoing adrenal surgery.


An analysis of SV40-induced transformation of hamster kidney tissue in vitro. IV. Studies of the pathology of hamster tumors induced with SV40-transformed hamster cell clones.


Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji).


Chemotherapy in the treatment of leukemia and Wilms' tumor.


Differential metabolic activity in Paget's cells and associated epithelia of the vulva.


A long-term study of sarcoid and its modification by steroid therapy. Lung function and other factors in prognosis.


The pharmacology of pressor drugs.

The pharmacology of pressor drugs.


An evaluation of the perchlorate discharge test.


Specificity of the "tibia test" in intact immature female rats.


Granular-cell myoblastoma of the bronchus. Report of a case.


Laser action at the cellular level.

Laser action at the cellular level.


Protective effect of antibody to parainfluenza type 1 virus.


Changes in lymph node size induced by lymphangiography.


Enhanced growth of human embryonic cells infected with adenovirus 12. Fibroblast-like cells from human embryonic lung were infected with adenovirus type 12, and they survived as an established line, with the characteristics of "transformation" following considerable cellular killing. Inclusion bodies disappeared and cells became resistant to reinfection with type 12 virus as they grew in thick multilayered strands, and giant and syncytial cells became commonplace. An induced new cell antigen demonstrable by complement-fixation and fluorescent-antibody studies persisted for at least 20 culture passages after infection.


Zollinger-Ellison syndrome with interesting variations. Report of twelve cases including one of carcinoid of the duodenum.


Lobar cirrhosis with nodular hyperplasia (hamartoma) of the liver treated by left hepatic lobectomy.


Response of cultured chicken brain neuroglial cells to infection with Rous sarcoma virus.


Immunology of the mouse mammary tumor virus. Correlation of the immunodiffusion precipitate line with type-B virus particles.


Carcinogenic activity of analogues of p-dimethylaminoazobenzene. V. Effect of added methyl groups in the pyridine series.


Cytopathologic changes in fowlpox (turkey origin) inclusion body formation.


Tissue concentration differences during active transport of calcium by intestine.


Experimental respiratory infection with poxviruses. I. Clinical virological and epidemiological studies.


Experimental respiratory infection with poxviruses. II. Pathological studies.


An investigation of the incidence, epidemiology and control of Simian virus 5.


Oxygen uptake by Clostridium welchii type A: its possible role in experimental infections in passively immunised animals.


Hypophosphatasia.

Hypophosphatasia.


Exaltation of the development of poliovirus by semicarbazide. Grossberg, Sidney E. (Institut Pasteur, Paris, France), Marguerite Lwoff, and André Lwoff. Exaltation of the development of poliovirus by semicarbazide. J. Bacteriol. 92:1473-1477. 1966.-Semicarbazide (NH(2)-NH-CO-NH(2)) remarkably increases the development of poliovirus. In single-cycle experiments, semicarbazide (SCZ) acted to (i) diminish the length of the latent period, (ii) increase the rate of production of virions, and (iii) increase the final yield of virus. These effects were demonstrable in KB cells, a human malignant cell line, and other primate cells. The dose range over which the compound exerts its effect was relatively large, i.e., from 0.3 to 20 mm, whereas higher concentrations inhibited viral growth. SCZ achieved its exalting effect only when it was added during the first 3 hr of viral development; later addition had no effect. Withdrawal of SCZ at intervals during the viral cycle confirmed that its action occurred within 3 hr after infection. The possible mode of action of SCZ is discussed. SCZ appeared to act, at least in part, by increasing the rate of synthesis of the viral ribonucleic acid.


Reaction of endotoxin and surfactants. I. Physical and biological properties of endotoxin treated with sodium deoxycholate. Ribi, E. (Rocky Mountain Laboratory, Hamilton, Mont.), R. L. Anacker, R. Brown, W. T. Haskins, B. Malmgren, K. C. Milner, and J. A. Rudbach. Reaction of endotoxin and surfactants. I. Physical and biological properties of endotoxin treated with sodium desoxycholate. J. Bacteriol. 92:1493-1509. 1966.-Endotoxins from three species of gram-negative bacteria were shown to be dissociated by the bile salt sodium deoxycholate (NaD) into nontoxic subunits with molecular weights of about 20,000. When the bile salt was removed by dialysis, the subunits reaggregated in an orderly manner to form a relatively uniform population of biologically active endotoxin particles with average molecular weights of 500,000 to 1,000,000. If a small amount of human plasma was added to the dissociated endotoxin before removal of the NaD, reassociation apparently did not occur and the preparation remained nonpyrogenic. However, the plasma protein could subsequently be removed from the endotoxin subunits, and reaggregation to the toxic form would then occur. The studies on the physical nature of endotoxin performed with biophysical solution techniques were supplemented and confirmed by direct examination of the endotoxin polymers by electron microscopy. The results of these studies were consonant with the theory that the biologically active endotoxic elements are composed of micellar aggregates of linear lipopolysaccharide subunits.


Correlation between infectivity and physical virus particles in human cytomegalovirus. Benyesh-Melnick, Matilda (Baylor University College of Medicine, Houston, Tex.), Fern Probstmeyer, Robert McCombs, Jean P. Brunschwig, and Vladimir Vonka. Correlation between infectivity and physical virus particles in human cyto-megalovirus. J. Bacteriol. 92:1555-1561. 1966.-Infectivity titers [measured as plaque-forming units (PFU)] and particle counts by the sedimentation pseudo-replication technique were determined for crude, unpurified, intracellular preparations of two different strains of human cytomegalovirus. Unlike the high particle-infectivity ratio of 10(6) to 10(8) previously reported for these viruses, the number of total particles per PFU ranged from 160 to 490 with strain AD-169 and from 176 to 1,050 for strain C-87. Interpretation of particle-PFU ratios of intracellular cytomegalovirus in terms of particle morphology is not conclusive at this time. The number of enveloped forms found varied between 0 and 34% of the total particles counted. However, the true proportion is probably greater, because envelopes were found to be destroyed by the enzyme treatment used in preparing the specimens for examination in the electron microscope. The number of full particles found ranged between 4 and 31% of the total particles counted. The particle per PFU ratio of extracellular virus was found to be three- to fivefold lower than that of intracellular virus.


Estrogen therapy in inhibition of growth.


Cushing's syndrome due to bilateral adrenocortical hyperplasia caused by a benign adrenal medullary tumor.


Metabolic clearance rate and blood production rate of testosterone and androst-4-ene-3,17-dione under basal conditions, ACTH and HCG stimulation. Comparison with urinary production rate of testosterone.


An analysis of factors determining the circadian pattern of aldosterone excretion.


Effect of corticosteroids on the cardiovascular responses to angiotensin and norepinephrine.


Atrophy of laryngeal muscles in vagal paralysis.


The effect of host age, virus dose and route of inoculation on inapparent infection in mice with Japanese encephalitis virus.


Effect of diabetogenic hormones on transport of glucose in small intestine in vitro.


Growth and cytopathic effect of H type rhinoviruses in monkey kidney tissue culture.


BAI strain A avian (myeloblastosis) leukosis virus from myeloblast tissue culture.


Hyperresponsivity to angiotensin induced in rats by behavioral stimulation.


The need for calcium in adrenomedullary secretion evoked by biogenic amines, polypeptides, and muscarinic agents.


Comparison of two different transplantable mammotropic pituitary tumors. Hormone content and effect on host.


Role of ingredients in alginate impression compounds.


Effects of cortisol on interferon production by mouse peritoneal leukocytes and spleen in vitro and in vivo.


Diuretic effect of angiotensin in the chicken.


Multiple enzyme determinations in sera and livers of tumor bearing hamsters.


Bone formation in normal and vitamin D-treated rachitic rats during the administration of polyphosphates.


In vitro inhibition of intestinal fluid and electrolyte transfer by a non-beta islet cell tumor.


Effect of 8-azaguanine on encephalomyocarditis virus multiplication.


Enhancement of polio-RNA infectivity by dimethylsulfoxide.


Viral pollution of shellfish. 1. Some basic facts of uptake.


Antiviral activity of N1-furfurylbiguanide hydrochloride (FFB) in vitro.


An interferon-like viral inhibitor in body fluids of endotoxin-injected rabbits.


Induction of neoplasia in vitro in hamster thyroid tissue by SV40 and adenovirus 7-SV40 "hybrid" (STRAIN LLE46).


The Virus Watch program. IV. Recovery and comparison of two serological varieties of adenovirus type 5.


Comparison of intestinal absorption and esterification of 4-C14 vitamin D3 and 4-C14 cholesterol in the rat.


Prevention and interruption of SV40 induced transplantation immunity with tumor cell extracts.


Simultaneous and combined vaccination against Newcastle disease and fowl pox.


Gross and microscopic lesions in the nasopharynx of pigs with Aujeszky's disease.


Determination of virus content, and possible diagnostic value of organs from pigs died of Aujeszky's disease.


Neurological presentations of insulin secreting tumours of the pancreas.


The in vitro determination of the D antigens of poliomyelitis viruses. I. The gel diffusion tes.


Virus specific antigens in mammalian cells infected with herpes simplex virus.


A study of the reaction of glyceraldehyde with glyceraldehyde 3-phosphate dehydrogenase.


Serine biosynthesis in rat liver. Regulation of enzyme concentration by dietary factors.


Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase.


Mixed function oxidation. VI. Purification of a tightly coupled electron transport complex in camphor lactonization.


Peripheral neuropathy following tetanus toxoid administration.


Studies of some substances with antiviral activity. 3. The inhibition of poliovirus type 1 and 2 induced cytopathogenic changes in cell cultures of human embryonic kidneys by derivatives of thiazolidine acetic acid.


Duration of cytomegaloviruria in nursery children.


Studies on the molecular mechanism of the radioprotective effect of serotonin.


Free radical formation in amino acids exposed to thermal hydrogen atoms.


The radiation sensitivity of normal and polyoma-transformed rat embryo cells.


Experience with a selective medium in the routine diagnosis of gonorrhoae, with special regard to rectal gonorrhoae in women.