Thermostable Clostridium perfringens as cause of food poisoning outbreak.


Effect of ischaemia on adrenocortical corticosterone secretion in the rat.


Differential diagnosis of arteriovenous aneurysms and brain tumors on the basis of the angiographic pattern.


Recurrent jaundice in pregnancy. II. A study of the estrogens and their conjugation in late pregnancy.


Visualization of the choroid plexus on the technetium 99m brain scan. Clinical significance and blocking by potassium perchlorate.


Sampling of enamel particles by means of strong acids for density measurements.


Psychological stress in cleft palate etiology.


Enzymes of glycolytic cycle in periodontal tissues of the guinea pig.


Influence of angiotensin, vasopressin or changes in flow rate on vasoconstriction, changes in volume and [3H]-noradrenaline release following postganglionic sympathetic nerve stimulation in the isolated cat spleen.


Clinical study on the dephosphorylation of adenosine triphosphate by human sera, with special references to serum acid ATPase activity in essential hypertension.


Erythropoietin release associated with Wilms' tumor.


Cystosarcoma phyllodes.

Cystosarcoma phyllodes.


Effect of infantile malnutrition on growth.


Biochemistry and kinetics of the renin-angiotensin system.


Renin, angiotensin, aldosterone and hormonal regulation of arterial pressure and salt balance. Introductory remarks.


Intrarenal function of angiotensin.

Intrarenal function of angiotensin.


A method for routine determination of plasma triglycerides.


Humoral factors in the regulation of renal sodium excretion.


Fluorescent lamp stabilizer for filter fluorometers.


A new system for the biological determination of the sedimentation constant.


Coccidiosis in the guinea pig small intestine due to a Cryptosporidium.


Determination of nucleic acids with concentrated H-2-SO4. II. Simultaneous determination of ribo- and deoxyribonucleic acid.


Host range studies of two porcine polioencephalomyelitis viruses.


Reactivation of herpetic keratitis in rabbit. II. Repeated reactivations in the same host.


Nucleic acid interactions. VI. Effects of steroidal diamines.


Influence of phyrophosphate on modification of myosin by beta-hydroxyethyl-2,4-dinitrophenyl (HEDD).


Tritiated thymidine incorporation into KB cells infected with parainfluenza 3 virus.


Properties of Rhodospirillum rubrum subchromatophore particles obtained by treatment with Triton X-100.


Immunization programs for dairy cattle.

Immunization programs for dairy cattle.


The synthesis of [1,2-3H]vitamin D3 and the tissue localization of a 0.25-mu-g (10 IU) dose per rat.


Histochemical mapping of succinic dehydrogenase and cytochrome oxidase in the spinal cord, medulla oblongata and cerebellum of squirrel monkey (Saimiri sciureus).


A sensitive radioimmunoassay for plasma ACTH levels.


Disturbance of pituitary-adrenal interrelationships in benign intracranial hypertension (pseudotumor cerebri).


Growth behavior of spontaneous hepatoma and OAT-induced hepatoma in mice.


Serum placental lactogen levels during pregnancy and in trophoblastic disease.


Genital herpes simplex infection. Virologic and cytologic studies.


Clinical malignancy of endocrine tumors of the ovary and dysgerminoma.


A renin-like substance in the human placenta.


Enzyme histochemistry of a masculinizing arrhenoblastoma.


Endemic outbreak of canine hepatitis (Rubarth's disease) among bears.


Histochemical mapping of succinic dehydrogenase and cytochrome oxidase in the pons and mesencephalon of squirrel monkey (Saimiri sciureus).


Surgical treatment of squamous-cell carcinoma of the vulva.


Intracellular localization of the golgi apparatus-associated phosphatase in rat kidneys.


Primary mass culture of Yoshida sarcoma and rat ascites hepatomas.


Histochemical studies on enzymes in lung tumors. I. Enzyme activities in human lung cancer.


In vitro test for sensitivity of tumor to carcinostatic agents.


On histochemical studies of the various organs of spontaneously hypertensive rats.


Histochemical studies on enzymes in lung tumors. II. Enzyme activities in mouse and rat lung tumors induced by 4-nitro-quinoline 1-oxide.


Progressive atrophy of skeletal muscles. Tips on differential diagnosis.


Peripheral neuropathy.

Peripheral neuropathy.


Clinicopathologic conference. Abdominal pain relieved by food.


Bovine ulcerative mammillitis caused by a herpesvirus.


Polyoma virus. 3. On the nature of the virus receptors on the mouse embryo cells.


Hemodynamic effects of angiotensin during surgical anesthesia.


Quantitative studies on fabrics as disseminators of viruses. II. Persistence of poliomyelitis virus on cotton and wool fabrics. The length of time that poliovirus could be recovered from wool gabardine and blanket, and from cotton sheeting, terry cloth, and knit jersey fabrics was determined under conditions of controlled temperature and humidity (25 C in 35 and 78% relative humidities). Three types of exposure of the fabrics to viruses were used: direct contact, aerosol, and virus-containing household dust having a high content of textile fibers. When held in 35% relative humidity, virus persisted for 20 weeks on wool fabrics, but only 1 to 4 weeks on cotton fabrics. At this relative humidity, virus titers on wool fabrics decreased rapidly to low but detectable levels which persisted for long periods of time, whereas in 78% relative humidity the decrease in virus titer was less rapid, but the period of viral persistence was shorter. Generally, virus titers on cotton fabrics held in both relative humidities decreased exponentially to an undetectable level. The method of exposure to virus had a definite effect on the duration of viral persistence on a given fabric. Virus contained in household dust was least stable.


Influence of salts on foot-and-mouth disease virus. The effect of sodium and magnesium chloride in 1 and 2 m concentration at temperatures of 37 and 50 C on type C, strain 149, foot-and-mouth disease virus during storage for 6 days was studied. The exclusively passaged cattle strain and its tissue culture-adapted line were compared. Preparations of the various chemicals and their concentrations were made directly in suspensions of the virus, which, together with untreated control virus suspensions, were stored at indicated temperatures and tested daily for concentration of virus present. Both 1 and 2 m concentrations of Mg markedly slowed the degradation of the bovine-passaged virus, as compared with untreated virus stored at 37 or 50 C. Such was not the case with 1 and 2 m concentrations of Na at 37 and 50 C, in which instance the treated virus was degraded faster than the untreated controls at 37 C, and but slightly influenced at 50 C. The tissue culture-adapted virus at the 25th passage was not stabilized by any concentration of chemical additive either at 37 or 50 C, except for 1 and 2 m concentrations of Na at 37 C, which partially retarded degradation of the virus. After 91 passages of the virus in tissue culture, only a suggestion of the influence of 1 and 2 m concentrations of Na at 37 C remained to show a stabilizing effect. These responses tend to separate the bovine-passaged virus from the tissue culture-adapted virus under the conditions of this study.


Survival and recovery of enterovirus from foods. Type 1 poliovirus and type B1 and B6 coxsackieviruses added to eight commercial frozen or convenience foods before storage at room temperature, 10 C, and -20 C were still viable after various intervals of time up to 1 week, 1 month, and 5 months, respectively. Infectivity titers were determined in monkey kidney tissue culture. Decomposition which took place in food stored at room temperature did not affect the survival of virus, and antibiotics controlled bacterial growth during assay. A rapid, significant reduction in type B6 coxsackievirus was observed in cole slaw. Preliminary data indicate that sodium bisulfite could be the responsible ingredient. A less rapid reduction of type 1 poliovirus and type B6 coxsackievirus was found in hashed brown potatoes when stored at 10 C.


Synovial sarcomas of the neck.

Synovial sarcomas of the neck.


Severity of smallpox and virulence of causative virus strains.


The effect of lethal doses of x-irradiation on the enzymatic activity of mitochondrial cytochrome c.


The effect of o,p-DDD in the chicken.

The effect of o,p-DDD in the chicken.


Oligosyndactylism, an early embryonic lethal in the mouse.


A re-evaluation of the skin test of herpes simplex virus.


Stress stimulation of drug metabolism in the rat.


Attempts to demonstrate infectious virus in human and bovine fibroblastic cells morphologically transformed in vitro by Rous sarcoma virus.


Localization of nucleic acids in the cells of a monkey tissue culture during the development of the vegetative form of the SV40 virus.


An isolated guinea pig kidney perfusion preparation for studying the effect of pharmacologically active substances.


Femoral neuropathy from heparin hematoma. Report of two cases.


Environmental factors influencing the hyperfine structure of manganous low-temperature electron paramagnetic resonance spectra. Hyperfine structure is observed in low temperature (T = -180 degrees C) EPR (electron paramagnetic resonance) spectra of a number of solutions containing Mn(++) ions 13, 15) which have characteristics in common with low temperature EPR spectra from biological substances such as mitochondria and microsomes (1-4). This investigation is an attempt to understand the features of these signals in terms of the molecular environment of the manganous ion, and a qualitative explanation for the observations reported here is advanced in terms of the amount of axial distortion of a manganese hydrate in different environments.


Ultrastructure of a chemodectoma.

Ultrastructure of a chemodectoma.


The mechanism of the push and pull principle. VII. Endocrine effects of chlordiazepoxide, diazepam and guanethidine.


Tarsal tunnel syndrome.

Tarsal tunnel syndrome.


Immunologic studies of adrenocorticotropic hormone (ACTH): effect of carboxypeptidase digestion on biologic and immunologic activities.


Reduced aldosterone excretion in patients with autonomic insufficiency.


Diurnal variation of plasma 17-hydroxycorticosteroids in children.


The preparation and characterization of mitochondria from developing red blood cells.


Cold doesn't affect the "common cold" in study of rhinovirus infections.


Dactinomycin in Wilms' tumor.

Dactinomycin in Wilms' tumor.


Pancreatic islet cell tumours.

Pancreatic islet cell tumours.


Mesenchymal hamartoma of the liver. Report of a rare case.


Shock as a complication of the nephrotic syndrome.


Cytomegalic inclusion disease.

Cytomegalic inclusion disease.


An evaluation of the lipiodol test for the detection of steatorrhoea.


Polymyalgia rheumatica. A rheumatic disease of the elderly.


Effects of ionizing radiation on two gelatin fractions. 3. Carbonyl group analyses and electron spin resonance studies.


Effect of glidants in tableting.

Effect of glidants in tableting.


Radiographic findings in hypothalamic acceleration of growth associated with cerebral atrophy and mental retardation (cerebral gigantism).


A simple, practical technic of lymphography.


Effect of vasopressor substances on the thoracic duct lymph flow.


Multiple granular cell myoblastoma.

Multiple granular cell myoblastoma.


Acute respiratory illness with Mycoplasma pneumoniae. An outbreak in a home for children.


The use of gel filtration to distinguish between endonucleolytic and exonucleolytic types of degradation.


Human leukemia virus in mice.

Human leukemia virus in mice.


Prophylactic antibiotics and postoperative endophthalmitis.


The natural occurrence of a uracil-5-peptide and its metabolic relationship to guanosine-5'-monophosphate.


Isolation of Sendai virus RNA from infected cells by the method of thermic fractionation.


The polysomes and the messenger ribonucleic acid content of hepatoma 223.


Genetic marker studies of poliovirus. I. Natural variation.


Respiratory illness and viral infection in an Edinburgh nursery.


Experimental infection of common terns with Tern virus: influenza virus A-Tern-South Africa-1961.


Genetic marker studies of poliovirus. II. Strains isolated from cases of poliomyelitis associated with the administration of live attenuated vaccine.


Intermittent hemodialysis for chronic renal failure.


Electron microscopic observations on Herpesvirus hominis (herpes simplex virus) encephalitis in man.


Ultrastructural alterations of hepatic microbodies.


Electron spin resonance study of thermal effects in irradiated deoxyribonucleic acid.


Effect of nitrous acid on polyoma virus.


Angiography in primary hepatic carcinoma.


Treatment of parotid tumors.

Treatment of parotid tumors.


Iron-loading, fibrosis, and hepatic carcinogenesis.


Antirachitic sterols in chicks. Rachitic bone lesions in chicks after multiple graded doses of vitamin D and dihydrotachysterols.


Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide. This paper describes the experimental and clinical findings of acrylamide intoxication in a human being. It is believed that this is the first such case to be recorded in the medical literature.Acrylamide is widely used as a "chemical grout". It is pumped into dirt, clay and stone walls of excavations in a liquid state together with a catalyst, and it then polymerizes to make a watertight shield.This chemical is neurotoxic in its non-polymerized form and can be absorbed through the intact skin, mucous membranes and lungs. In spite of warnings with regard to its handling, this worker became careless, and developed a contact dermatitis and a polyneuropathy with bluish cold extremities which dripped perspiration.In six months' time after his removal from contact with the chemical the patient made a complete clinical recovery. He was advised not to work with the chemical.


A re-evaluation of the place of major extirpation in the management of patients with metastatic mammary carcinoma. Clearly defined indications for major extirpation procedures in metastatic mammary carcinoma are lacking. A reassessment of experience with 222 patients (133 after adrenalectomies and 89 after hypophysectomies) was therefore undertaken. This experience has changed our previous opinions that such procedures should be used only at the end of a sequential program of treatment.It is now felt that extirpation is only contraindicated in menopausal women with a duration of disease less than two years or when there is symptomatic disease of vital organs. Otherwise, early extirpation is recommended. When vital organ involvement is recognized in the asymptomatic stage or when screening of premenopausal women by castration indicates continuing hormonal dependency, then early extirpation is indicated.Both the qualitative and the quantitative responses achieved exceed those obtained by other measures when widely disseminated disease is present. The objective remission rate (34% after adrenalectomy and 19% after hypophysectomy) for longer than six months is worth while.


Erythropoietin-producing Wilms' tumor.

Erythropoietin-producing Wilms' tumor.


Relation of cardiac work to survival in cardiogenic shock in dogs.


Effects of mammalian hypophysial hormones, placentral gonadotrophins, gonadal hormones, and adrenal corticosteroids on ovulation and spawning in hypophysectomized catfish, Heteropneustes fossilis (Bloch).


Absence attacks and diffuse neuronal disease.


Electron spin resonance studies of free radical turnover in gamma-irradiated single crystals of alanine.


The relationship between dental and skeletal maturation in Chinese children.


Changes in glutamic-alanine transaminase activity in response to corticoid treatment in hepatoma and the precancerous liver of rats induced by 3'-methyl-4-dimethyl amino-azo benzene.


The adrenal response to surgical trauma.


Surgical methods in syndactylism. Evaluation of 208 operations.


Histochemical observations on Posthodiplostomum minimum. 3. Alkaline phosphatase activity in metacercariae and adults.


Immunogenicity of synthetic angiotensin II.


The value of corticosteroids in the treatment of infectious mononucleosis.


Suppression of interferon and antibody and multiplication of Newcastle disease virus in cytomegalovirus infected mice.


Effect of hyperbaric oxygen on Clostridia in vitro and in vivo.


Attachment of modified erythrocytes to phagocytic cells in absence of serum.


Amino acid composition of three immunological types of foot-and-mouth disease virus.


In vitro production and inhibition of aortic vasoconstriction by mercuric, cadmium, and other metal ions.


Serotonin-bradykinin synergism in the mammalian capillary bed.


A study of teratogenic effects of particulate compounds in the amniotic cavity of chick embryos.


Fixation of topically applied fluoride in enamel.


Lack of effect of alpha-ethyltryptamine on ACTH secretion when blood pressure is held constant.


Effect of temperature and drug therapy on anthrax intoxication.


Femoral neuropathy from the lithotomy position: case report and new leg holder for prevention.


Evaluation of arteriography in obstetrics.


Effect of sewage treatment on recovery of poliovirus following mass oral immunization.


Plasma angiotensinase activity in hypertensive patients.


EPR measurements of substrate interaction with cytochrome P-450.


Rat liver and hepatoma polysome-membrane interaction in vitro.


The role of metal ions in the gamma-radiolysis of dry metal-ribonuclease complexes.


The effects of adenine nucleotides on pig heart malate dehydrogenase.


Vitamin D mediated synthesis of rapidly labeled RNA from intestinal mucosa.


The isolation of herpes virus from Burkitt tumours.


Differential consumption of coagulation factors resulting from activation of the extrinsic (tissue thromboplastin) or the intrinsic (foreign surface contact) pathways.


The isolation in mice of strains of herpes virus from Burkitt tumours.


Studies on the anti-tumour activity of aliphatic aldehydes. II. Effects on survival of Yoshida ascites hepatoma-bearing rats.


Changes with age in fragmentation of cellular nucleus DNA.


Diagnosis and treatment of skin tumors in the AGED.


Eosinophilic granuloma of the gastro-intestinal tract.


Ontogeny of macrophage resistance to mouse hepatitis in vivo and in vitro. Adult or weanling C(3)H mice were found to be genetically resistant to a strain of mouse hepatitis virus. Infant C(3)H mice, however, developed infection and died from mouse hepatitis virus when minimal infectious doses of virus were given to them. There was a delay in the time of death compared to that of the genetically susceptible strain, and the virus recovered from these mice had increased pathogenicity for C(3)H mice. The ontogeny of resistance to hepatitis in the C(3)H mice thus progresses from delayed susceptibility to complete resistance as the age of the host increases. It is reflected in increased resistance of macrophages derived in vitro from liver cultures of infant mice of different ages. This increase in resistance with age was reduced by maintaining the cultures for a longer period of time before inoculation, or by increasing the number of explants in a given culture. Resistant cells were uniformly furnished by mice age 16 days, or more. It is concluded that a process of maturation of resistance of the cells takes place after the mice are born, but that this does not continue under in vitro conditions, and that it may be modified by the environment of the cells.


Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. II. The effect of pertussis vaccine on the thoracic duct lymph and lymphocytes of mice. The 24 hr volume flow, cell concentration, and total cell output of thoracic duct fluid from mice with pertussis-induced hyperlymphocytosis were markedly reduced when compared with values obtained in normal animals. An increase in the number of circulating lymphocytes occurred in several of the pertussis-treated mice despite the presence of an indwelling thoracic duct cannula. The drainage from such animals also showed a reduced cell concentration and total cell output. It is suggested that lymphocyte recirculation may be minimal in pertussis-induced lymphocytosis, and the evidence obtained also suggests that lymphocytes may enter the blood stream by direct routes during the course of the reaction.


Demonstration by immunofluorescence of the fixation of perfused antibody to human collagen in human kidney. Rabbit serum containing antibody to human collagen, perfused through human infant kidneys obtained at autopsy, gives an immunofluorescent reaction with an antigen in the basement membranes of the glomeruli and the tubules. This reaction was shown to be specific by the absence of reaction with normal rabbit serum, antibody to carp collagen, or anti-human collagen serum absorbed with human collagen. Slight cross-reactions were found in the human kidneys with antibody to chicken or rat collagen. There was no evidence that a collagen-like protein in human serum or an antigen common to human erythrocytes and renal glomeruli enters into this immunofluorescent reaction. Perfusion of the kidneys with purified collagenase before the introduction of the antibody to human collagen altered the antigen so that antibody could not be demonstrated in the basement membranes by immunofluorescence. Testicular hyaluronidase used in the same way did not affect the immunofluorescent reaction. This method of perfusion provides another means for studying antigens in human organs by immunofluorescence. These observations in human kidneys extend our earlier findings in laboratory animals and indicate that an antigen, collagen, is also present in human renal glomerular and tubular basement membranes.


In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses. Primary weanling hamster kidney cultures were transformed with the adeno 2-SV40, adeno 3-SV40, and adeno 12-SV40 hybrid viruses and with adenovirus type 12. The transformed cell lines which were established were characterized with respect to morphology, virus and antigen content, and chromosome aberrations. The adeno 2 and adeno 3-SV40 hybrid transformed cells had the morphology and T antigen content characteristic of SV40 transformations; cells transformed by the former hybrid had cytogenetic changes typical of SV40-transformed cells as well. The adeno 12-SV40 transformed cells were similar morphologically to adeno 12-transformed cells, contained both the SV40 and adeno T antigens and demonstrated the karyotypic instability of SV40-transformed cells, indicating that both viral genomes are operative in these cells. Although the results indicate that the SV40 genome in hybrids derived from the moderately or nononcogenic adenoviruses supplies the determinants for most of the characteristics investigated, and perhaps for oncogenesis, evidence was presented which suggests that a portion of a nononcogenic adenovirus genome may be integrated in adeno 2-SV40 transformed cells and directs the synthesis of adenovirus T antigens.


In vitro transformation by the adenovirus-SV40 hybrid viruses. 3. Morphology of tumors induced with transformed cells. Tumors induced with hamster kidney cells transformed by the adeno 2-, adeno 3-, adeno 7-, and adeno 12-SV40 hybrid viruses, and by adenovirus type 12, were examined histologically. The tumors induced with adeno 2-, adeno 3-, and adeno 7-SV40-transformed cells were similar to tumors induced with SV40-transformed hamster kidney cells but contained cells intermediate in morphology between SV40 and adenovirus tumor cells and occasionally contained nests of adenovirus-like cells. Cells transformed by the adeno 12-SV40 hybrid and by adenovirus type 12 gave rise to morphologically similar tumors. The results suggest that both viral genomes are operative in hybrid-transformed cells but that one genome is apparently responsible for the predominant morphology of the tumor. Evidence that the morphology of a single transformed target cell is determined by the transforming genome was discussed.


Locally advanced lung carcinoma with favorable prognosis.


Virus particles and murine leukemia virus complement-fixing antigen in neoplastic and nonneoplastic cell lines. Twenty-seven lines of murine tissue cultures derived from 12 different cell pools and grown on various media were examined with the electron microscope for morphologically detectable virus particles. They were also tested for complement-fixing mouse leukemia virus antigens and for recoverable virus. A 100-percent correlation between results obtained by these two methods is reported. An additional 19 lines from 8 different cell pools were examined for either virus particles or complement-fixing antigens. All lines were assayed for neoplastic transformation. Seven cell pools gave rise to lines showing evidence of contamination with leukemia virus. Since most of these lines had also undergone "spontaneous" neoplastic transformation in vitro, this virus cannot be excluded as a possible cause of the neoplastic change, or of influencing it. The remaining cell pools gave rise to lines with no evidence of contamination with leukemia virus;but most of these lines also underwent similar transformation. These results suggest that "spontaneous" neoplastic transformation can occur in the absence of detectable mouse leukemia virus.


Interpretation of fundus signs in angioid streaks.


The management of keratoconjuctivitis sicca.


Respiratory syncytial virus. An outbreak of acute respiratory illnesses in a home for infants.


Experimental observations on intraportal inoculation with E. histolytica.


Thermal and chemical burns of the head and neck.


Pyridine nucleotides. I. Radiometric determination of minute quantities of diphosphopyridine nucleotides.


Studies on the ultraviolet fluorescence of vitamin D and related compounds in acid-alcohol solutions.


Methods for the analysis and preparation of adenosylmethionine and adenosylhomocysteine.


Electron paramagnetic resonance studies on the ferredoxin from Clostridium pasteurianum.


Identification of the nucleoside monophosphate end-group on the product of the polynucleotide phosphorylase reaction.


Perillyl alcohol dehydrogenase from a soil pseudomonad.


The solvent denaturation of double-stranded RNA from poliovirus infected HeLa cells.


Electron spin resonance studies of ferrihaemoglobin MOsaka.


Nicotinamide-adenine dinucleotide dehydrogenase activity of human erythrocyte membranes.


Carbamylphosphate, a preferential substrate of K+-dependent phosphatase.


Neural injury resulting from epidural injection of dimethylsulfoxide and procaine base.


Role of norepinephrine and 5-hydroxytryptamine in the delayed phase of the inflammatory reaction in rats.


Pyrimidine dimers in ultraviolet-irradiated DNA's.


The follow up of hydatidiform mole.

The follow up of hydatidiform mole.


Clinical choriomatosis.

Clinical choriomatosis.


Gonadotrophin excretion, pelvic arteriography and treatment in post-molar trophoblastic disease.


The diagnosis of insuloma.

The diagnosis of insuloma.


Histochemical examinations in mucosal tongue atrophy.


Percutaneous transhepatic cholangiography.


Carcinoma of the floor of the mouth. Review of clinical factors and results of treatment.


Cancer of the nasopharynx: 142 patients treated in the 11 year period 1950-1960.


Therapy of lymphangiosarcoma of the chronically edematous limb. Five-year cure of a patient treated by intra-arterial radioactive yttrium.


Radiation therapy of sarcoma of the bone and soft tissue.


Colloidal thorium dioxide (thorotrast) in radiology with emphasis on hepatic cancerogenesis. A case report of occluded carotid and jugular vessels with nerve injuries and a case of hepatoma, 27 and 33 years after its administration.


The catalytic properties of tyrosyl ribonucleic acid synthetases from Escherichia coli and Bacillus subtilis.


Immunochemical studies on blood groups. XXXIV. Structures of some oligosaccharides produced by alkaline degradation of blood group A, B, and H substances.


Effect of neutral salts on enzyme activity and structure.


Use of antibodies to sera of hypophysectomized animals in pituitary hormone analysis and the application of Landsteiner's inhibition test in agar gel immunoassays.


Incorporation in vitro of precursor into protein and RNA of rat adrenal glands.


Test for corticotrophin-producing function of pituitary using vasopressin.


An extra-adrenal effect of corticotrophin.


Mixed anaerobic infection in minor trauma.


The effect of synthetic angiotensin-II-amide and methopyrapone (SU 4885) on the histochemistry of the adrenal cortex of intact and hypophysectomized rats.


Experiences in treating excessive height in girls with cyclic oestradiol valerate. A ten year survey.


Steroid hormone formation by the rat ovary. IV. Formation of steroids from acetate-1-14C by neoplastic ovarian tissue.


Isolation of an adenovirus from the brain of a pig.


Studies on latent derivatives of aminoethanethiols as potentially selective cutoprotectants. IV. Enzymatic hydrolysis of cysteamine-S-phosphate.


Soft-tissue calcification induced by rare earth metals and its prevention by sodium pyrophosphate.


Ultrastructural changes produced by triparanol in Morris 5123 and Novikoff hepatomas.


Carcinogenesis in AKR mice injected at birth with benzo(a)pyrene and dimethylnitrosamine.


The oxidation of extramitochondrial reduced diphosphopyridine nucleotide in ascites tumor cells.


Effects of adrenocorticotropic hormone and growth hormone on the metabolism of N-hydroxy-N-2-fluorenylacetamide and on physiologic parameters.


Uptake and scanning of the salivary glands in man using pertechnetate-99m-Tc.


Screening data from the Cancer Chemotherapy National Service Center screening laboratories. XL. Plant extracts.


Clinical neuropathological conference.

Clinical neuropathological conference.


Histochemical localization of gastric and small bowel mucosal enzymes of man, monkey, and chimpanzee.


The abolition of the protective effect of Clostridium welchii type A antiserum by ferric iron.


Serological activity of staphylococcal polysaccharide. The polysaccharide from cell walls of coagulase-positive staphylococci coated both latex particles and tanned red cells for agglutination by human sera and by specific staphylococcal antisera. Treatment with trypsin or autoclaving destroyed the capacity of polysaccharide to coat particles but did not affect precipitation of antibody. Periodic acid destroyed both properties. The teichoic acid portion of the staphylococcal polysaccharide displayed precipitin activity similar to polysaccharide, but it did not coat either latex particles or tanned red cells. Teichoic acid did, however, inhibit specific agglutination of polysaccharide-coated particles or cells.


Adenosine phosphate hydrolases in cell fractions of Vitreoscilla. Bound, soluble, and whole-cell fractions of two strains of the gliding bacterium Vitreoscilla were found to contain two enzymes capable of hydrolyzing adenosine phosphates: a Mg(++)-activated adenosine triphosphatase with a temperature optimum of 37 C, and a Mg(++)-activated adenosine diphosphatase with a temperature optimum of 55 C. Both enzymes had an optimal pH response between 8.5 and 9.5. Maximal activation was achieved at an ionic strength of 0.2 for the adenosine triphosphatase and at 0.3 to 0.4 for the adenosine diphosphatase. Preliminary studies indicated a molecular weight of approximately 50,000 for the adenosine diphosphatase and a molecular weight greater than 60,000 for the adenosine triphosphatase. Comparisons are made with previously reported characteristics of these enzymes in other bacteria, and a hypothesis is offered as to the role these enzymes have in the gliding mechanism.


Bacterial metabolism of mevalonic acid.

Bacterial metabolism of mevalonic acid. Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and beta-hydroxy-beta-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free beta-hydroxy-beta-methylglutaryl-CoA, but not free mevaldate. The reaction favors mevalonate oxidation, and nicotinamide adenine dinucleotide, rather than nicotinamide adenine dinucleotide phosphate, acts as oxidant.


Some properties of heat-resistant and heat-sensitive strains of Clostridium perfringens. I. Heat resistance and toxigenicity. Heat resistance at 100 C (D-values), sporulating ratios, toxigenicity for mice, and lecithinase activity (as micrograms per milliliter of enzyme, ascertained by the lecithovitellin reaction) were determined for four strains of Clostridium perfringens. A definite inverse relationship between thermal resistance and toxigenicity was found. The D-values ranged from 17.6 for the most heat-resistant strain to 0.3 for the strain possessing the least heat resistance, with corresponding lecithinase activities from 25 to 133 mug/ml of enzyme. The sporulating ratios did not differ greatly between the strains. The heat stability of the toxin was greater at 100 C than at 75 C. There was a noticeable difference between the heat stabilities of the toxin in the culture fluids of the heat-sensitive and heat-resistant strains at pH 7.0 when the toxic filtrates were held at 100 C. At a holding temperature of 75 C, a similar but lesser difference was observed at pH 5.5. Heat resistance and lecithinase activity did not change when a substrain of the least heat-resistant parent strain was obtained through heat selection by a single transfer, or when the most heat-resistant strain was transferred serially 12 times.


Spectrophotometric and kinetic study of nitrite and formate oxidation in Nitrobacter winogradskyi. The reduction levels of cytochrome c and a(1) in intact Nitrobacter cells and cell-free extracts, during and after nitrite or formate oxidation, were examined in combination with the amperometric measurement of oxygen uptake. Quite different reduction patterns were observed when comparing nitrite oxidation by intact cells and cell-free extracts. An inverse relationship was observed between the rate of electron flow and the steady-state reduction level of cytochrome a(1). Parallel observations on nitrite oxidation, by use of formate and reduced nicotinamide adenine dinucleotide as electron donors, showed the influence of the high oxidation-reduction potential of the nitrite-nitrate system on cytochrome reduction. A value for the apparent activation energy of the overall nitrite oxidation process, amounting to 15 kcal, was found in a study of the temperature dependence of cytochrome reduction.


Effects of oxygen and heme on the development of a microbial respiratory system. The effect of adding hemin to anaerobically grown cells of a strain of Staphylococcus epidermidis, which was heme-deficient due to anaerobic growth, has been examined. Cells grown anaerobically in media containing hemin exhibited a marked increase in several oxidative activities as compared with cells grown anaerobically without hemin. The respiratory activity of whole cells and a cyamide-sensitive reduced nicotinamide adenine dinucleotide oxidase activity of cell-free extracts were increased fourfold. The content of enzymatically reducible pigments which exhibit difference spectra similar to cytochromes b(1) and o was also markedly increased. These pigments are mostly sedimented at 100,000 x g (1 hr). Hemin also caused a marked increase in respiratory activity when added directly to the anaerobic culture after the period of growth, but did not cause a similar increase in respiration when added to washed, resting-cell suspensions. Under the latter conditions, heme pigments were formed which exhibited difference spectra similar to, but not identical with, the spectra of pigments found in anaerobic cells grown in the presence of hemin. When resting suspensions of cells grown anaerobically without hemin were exposed to air, a rapid fourfold increase in respiratory activity and a limited increase in cytochrome-like pigments occurred. The presence of the heme precursor Delta-aminolevulinic acid during this aeration resulted in a rapid and marked increase in heme pigments, but only a slight stimulation of respiratory activity. The possible implications of these results for the roles which heme and oxygen play in the development of the respiratory system of this organism are discussed.


Metabolic changes in nicotinamide adenine dinucleotide in response to anthrax toxin. Bacillus anthracis produces a toxin both in vitro and in vivo which, when injected intravenously into rats, brings about the death of the animals accompanied by gross pulmonary edema. Lung tissue removed prior to death showed, in vitro, a 30% reduction in overall oxidative metabolism (Q(o2)), whereas the nicotinamide adenine dinucleotide (NAD)-independent succinic dehydrogenase remained unaffected. The NAD concentration in the lungs of injected animals was reduced by 50%. Upon addition of NAD, the Q(o2) of lung tissue from injected animals rose to control values. At 45 min after toxin injection, the serum lactate concentration began to rise, showing about a 3.5-fold increase over controls after 75 min. No changes occurred in the pyruvate concentration. These changes may be explained by increased use of the pyruvate for glycolytic energy production with further loss of NAD. Additional experiments with liver, spleen, kidney, and brain tissues showed that the toxin-induced reduction of Q(o2) is an effect specific for lung tissue. Brain tissue showed a significant increase in oxidative metabolism upon the addition of the toxin, whereas the other tissues remained unaffected. It is suggested that a principal effect of the toxin is to inhibit, in lung tissue, the regeneration of NAD in the respiratory chain.


The state of copper in Rhus laccase as compared with those in other copper complexes.


On the purification and properties of mushroom tyrosinase.


Studies on cell walls of Mycobacteria. II. Constitution of polysaccharides from BCG cell walls.


The oxidation of protein-bound hydroxylysine by periodate.


Studies on cytochrome oxidase. 3. Ligand reactions and Schiff base formation of heme a.


Nicotinamide adenine dinucleotide as a precursor of nicotine in Nicotiana rustica L.


Heme A of cytochrome c oxidase. I. Isolation from bovine heart.


The enzymatic cleavage of phosphate termini from polynucleotides.


Isolation and structure of cytidine diphosphate 6-deoxy-3-C-methyl-2-O-methyl-L-aldohexopyranoside (cytidine diphosphate vinelose) from Azotobacter vinelandii.


Structure and distribution of a disaccharide-carrying nucleotide and related nucleotides in hen oviduct.


Virus-like particles in established murine cell lines: electron-microscopic observations. Virus-like particles identical in morphology to the RNA tumor vi ruses have been observed by electron microscopy in six lines of murine L cells and one line of murine liver cells. Control cultures of embryonic mouse cells and 3T3 cells do not contain the particles, and no biologic activity has as yet been associated with them.


Mixed tumors of minor salivary glands.

Mixed tumors of minor salivary glands.


Severe spinal curvature in rats injected with a water-dispersible vitamin D3 preparation.


Localization of avian tumor virus group-specific antigen in cell and virus.


Origin of group-specific antigen of chicken leukosis viruses.


Metabolic requirements for infection by Rous sarcoma virus. II. The participation of cellular DNA.


The loss of photosensitivity of proflavine-sensitized encephalomyocarditis virus on contact with nonsusceptible cells.


Circulatory changes following angiotensin administration.


Rabbit uterus as a source of renin.

Rabbit uterus as a source of renin.


Absorption and electrolyte changes of intestinal mucosa following substrate induction.


Alkylation of cytochromes c. I. Properties of alkylated beef cytochrome c.


The effect of coenzyme on the S--N acyl migration in glyceraldehyde-3-phosphate dehydrogenase.


The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver.


Enzymes of glycogen metabolism in white blood cells. 3. Heterogeneity of glycogen phosphorylase from rat chloroma.


Enzymes of glycogen metabolism in white blood cells. II. Activation and inactivation of glycogen phosphorylase of rat chloroma.


The determination of the oxidation-reduction states of ubiquinone (coenzyme Q) in rat-liver mitochondria.


Electron transfer between ferro- and ferricytochrome c.


Purification and properties of cytochrome a of Candida krusei.


The effect of heat on the structure of foot-and-mouth disease virus and the viral ribonucleic acid.


Interference of actinomycin D with the replication of the herpes virus DNA. I. Difference in behaviour of cellular and viral nucleic acid synthesis following treatment with actinomycin D.


Interference of actinomycin D with the replication of the DNA of herpes virus. II. Relationship between yield of virus and time of actinomycin treatment.


The roles of three enzymes in messenger RNA degradation in cell-free systems from normal or phage-infected Escherichia coli.


Enzymic conversion of thymidine 3'-monophosphate to thymidine 3'-diphosphate and 3'-triphosphate.


Experimental studies on the bacteriocinogeneity in Cl. perfringens type A. II. Properties of isolated bacteriocines.


The chemistry of the polymyxin antibiotics.


Chemical structure of polymyxin D1.

Chemical structure of polymyxin D1.


Effects of angiotensin on the superior cervical ganglion of the cat.


In vivo assay for melanocyte lightening substances.


Mechanisms of pathogenesis in Listeria monocytogenes infection. 3. Carbohydrate metabolism. Several enzymes and metabolites concerned with carbohydrate metabolism were examined in mice infected with Listeria monocytogenes. Liver glycogen and glucose decreased parallel to severity of infection. The concentration of glucose in the blood fell to abnormally low levels with a hypoglycemia being most evident at 72 hr. There was a significant decrease in the activity of hepatic uridine diphosphate glucose-glycogen transglucosylase. This decrease in enzymatic activity correlated with the rate of glycogen depletion. Phosphorylase activity declined in a similar fashion, contraindicating enhanced glycogenolysis as the mechanism responsible for glycogen depletion. Although glucose-6-phosphatase decreased throughout the infection period, it did not appear to be the major metabolic defect causing hypoglycemia in Listeria-infected mice. Further distortion of carbohydrate metabolism was indicated by findings of increased levels of pyruvate and lactate in the blood of infected animals.


Effect of glucose on the formation of the membrane-bound electron transport system in Haemophilus parainfluenzae. The catabolism of glucose by Haemophilus parainfluenzae affected the formation of the primary dehydrogenases of the membrane-bound electron transport system. The formation of other components of the respiratory system, 2-demethyl vitamin K(2), cytochrome b(1), cytochrome c(1), and the cytochrome oxidases a(1), a(2), and o, is not affected by the catabolism of glucose. The formation of all components of the electron transport system is controlled by the identity and concentration of the terminal electron acceptors present in the growth medium.


The terpene-producing glands of a Phasmid insect. Cell morphology and histochemistry.


Myocardial "protective effect" of 5-OH tryptamine during tryptophan deficiency.


Goblet cells in an apical periodontal cyst. Report of a case.


Attempt at dynamic investigation of bioactivity of adrenal cortical zones after corticotrophine in the excreted urine of patients with articular disease.


Isolation of a bovine enterovirus.

Isolation of a bovine enterovirus.


Renewed interest in gases for contrast roentgenography.


A comparative study of roentgenographic techniques for detection of calcium pyrophosphate dihydrate deposits (pseudogout) in human cartilage.


A kinetic study of ternary complexes in the mechanism of action of liver alcohol dehydrogenase.


Fluorescence enhancement of uridine diphosphagalactose 4-epimerase induced by specific sugars.


The mitochondrial electron transfer chain.


The interrelationship between guanosine triphosphatase and amino acid polymerization.


Reversible inactivation of D-fructose 1,6-diphosphatase by adenosine triphosphate and cyclic 3' ,5'-adenosine monophosphate.


Inorganic pyrophosphate in parotid saliva and its relation to calculus formation.


Studies on the mechanism of action of glyceraldehyde 3-phosphate dehydrogenase. Absorbance and fluorescence properties of reduced nicotinamide-adenine dinucleotide complexes with glyceraldehyde 3-phosphate dehydrogenase.


Mixed salivary tumour of the nasal septum. Case report.


Fructose 1,6-diphosphatase from rabbit liver. VI. Functional tyrosyl residues in the active center.


Quantitative determination of chrysotile, amosite and crocidolite by x-ray diffraction.


Studies on 17-ketosteroids in juvenile diabetes mellitus.


The microbiological diagnostics of strains of Aeromonas shigelloides isolated in Cuba.


Effect of ACTH on open-field behavior, avoidance, startle, and food and water consumption.


Hemodynamically induced natriuresis in the presence of sodium retention resulting from constriction of the thoracic inferior vena cava.


Oxidative phosphorylation and respiratory control of brain mitochondria isolated from kernicteric rats.


The presence of distinct soluble and particulate trypsin inhibitors in human astrocytoma tissue.


Ultrastructural and enzymic studies of cholinergic and non-cholinergic synaptic membranes isolated from brain cortex.


The clinical application of a gas chromatographic method for the routine determination of urinary pregnanediol.


Metabolic pathways of the host cell important in the replication of Rous sarcoma virus in vitro.


Subcellular distribution of catecholamines in dog spleen.


Effect of drugs on the lipolytic action of hormones in isolated fat cells.


The prevalence of diabetes mellitus in patients with Addison's disease: measurements of serum insulin levels.


Manganese free radicals in cobalt-60 gamma-irradiated strawberries.


Reduced diphosphopyridine nucleotide-dependent diaphorase in foetal, newborn and adult cattle.


Neutralizing ability of sera from three strains of chickens for Rous sarcoma virus.


Functional and analytical histochemistry of the chicken lung lobule with particular reference to surfactant.


Inhibition of interferon production by a halogenated pyrimidine derivative: 5-fluoro-2'-deoxyuridine.


Studies on the inhibition of polyoma virus replication in vitro: comparison of the effects of phenethyl alcohol, 5-iodo-2'-deoxyuridine, puromycin, and actinomycin D.


Adrenocorticotrophic hormone and platelet stickiness.


The usefullness of human fibroblast cell lines for the isolation of viruses.


Epidemiology of parainfluenza 3 infection in sheep.


The phospholipid composition of the cerebrospinal fluid in children with mental deterioration.


Epidemiology of group II adenoviruses.

Epidemiology of group II adenoviruses.


Osteoclastoma of the heart.

Osteoclastoma of the heart.


Determination of glycogen with the anthrone reagent.


Studies in laser destruction of chemically induced primate hepatomas.


Effect of 1-adamantanamine hydrochloride on Rous sarcoma virus in vitro and in vivo.


Effect of tranylcypromine on adrenocortical secretion in the dog.


Influence of prednisolone and ACTH on the formation of insulin-binding antibodies.


Electron spin resonance studies of radiation damage in deoxyribonucleic acid.


Effect of chemical modification of keratin structure on its electron spin resonance spectrum after irradiation.


Thin-layer electrophoresis. 3. Studies on the dissipation of heat.


Ion exchange in fused salts. II. Distribution coefficients of some alkali metal ions on zirconium phosphate in fused nitrates.


Derivatographic studies of gas-chromatographic partition liquids. I.


Reagents for the detection of antioxidants on thin layers of silica.


Determination of the trisaturated glyceride content of fats by column chromatography of the mercuric acetate adducts on Florisil.


The effect of glycerol on the rate of movement of simple sugars on silica gel and cellulose thin layers.


The structure and function of the adhesive organ in strigeid trematodes. 3. Apatemon gracilis minor Yamaguti, 1933.


Studies on the structure and histochemistry of the male reproductive tract of Aspiculuris tetraptera (Nematoda: Oxyuridea).


Organic synthetics for augmentation mammaplasty: their relation to breast cancer.


Detection of altered cerebral arterial blood flow using technetium-99m pertechnetate and the gamma-ray scintillation camera.


Comparative experimental evaluation of several types of emulsified oily radiopaque materials in the cranial subarachnoid space.


Survey of bovine respiratory diseases with special reference to the serological examination of paired serum samples.


A simple method of inducing amoebic liver abscess in hamsters.


The introduction of a "reporter" group at the active site of glyceraldehyde-3-phosphate dehydrogenase.


The effect of radiation on collagen. I. Electron-spin resonance spectra of 2537-A-irradiated collagen.


Cytochrome systems in dark-aerobically grown Rhodopseudomonas spheroides.


Purification and properties of a bacteriophage receptor material from Streptococcus faecium.


Studies on plasma membranes. II. K+-dependent p-nitrophenyl phosphatase activity of plasma membranes isolated from rat liver.


Differences in the association of two glycolytic enzymes with plasma membranes isolated from rat liver and hepatoma.


A serological comparison of vegetative cell and ascus walls and the spore coat of Saccharomyces cerevisiae.


The effect of hyperbaric oxygen upon aerobic bacteria. I. In vitro studies.


The spheroplasts of bordetella pertussis.


Influence of clay minerals on microorganisms. I. Montmorillonite and kaolinite on bacteria.


Influence of triiodothyronine on plaque production by vesicular stomatitis virus.


Deterioration of solutions of reduced nicotinamide adeninedinucleotide (NADH2) during storage.


The enzymatic determination of lactic acid in faeces in glycosidase deficiency.


A simple method for the separate determination of cortisol and corticosterone in plasma.


Tumors of urinary tract origin in the female pelvis.


Assay of sex steroids in urine.

Assay of sex steroids in urine.


Preliminary notes on nucleic acid analyses in Rous sarcoma.


Comparison of sialic acid derivatives of cell surface and of whole cell in various hepatomata and normal liver in rat.


The determination of copper in quartz by neutron activation analysis.


Radiation protection studies with polyethylene.


Studies on lipoamide dehydrogenase of bakers' yeast. IV. Inactivation by metal ions in the presence of NADH2.


The optical rotatory dispersion of myosin A. V. Re-examination of changes in the optical rotatory power of myosin caused by adenosine triphosphate, inorganic pyrophosphate and p-chloro-mercuribenzoate.


A new cytochrome in neurophilic granules of rabbit leucocyte.


A hypothesis concerning patterns of deoxynucleotide metabolism in tumors in relation to rate of cell proliferation.


Immune adherence hemagglutination test as a new sensitive method for titration of animal virus antigens and antibodies.


Susceptibility and immunity in pigeons to Schmidt-Ruppin strain of Rous sarcoma virus.


Renal renin in unilaterally nephrectomized hypertensive rats.


Rabbit uterus as a possible site of renin synthesis.


Activation of rat-liver microsomal glucose 6-phosphatase by o- and p-tyrosine.


Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol. Mannitol is dissimilated by Aerobacter aerogenes via an inducible pathway initiated by a phosphotransferase system dependent upon phosphoenolpyruvate as the phosphoryl donor. A mutational block in this pathway can be suppressed either at the phenotypic level by induction of d-arabitol dehydrogenase, an enzyme fortuitously capable of converting mannitol to fructose, or genotypically by a constitutive mutation in the d-arabitol system.


Studies on the function of intracellular ribonucleases. IV. Some observations on the properties of ribosomes and polysomes from rat liver and hepatomas. Polysome and ribosome preparations from normal rat liver and from a series of transplantable rat hepatomas of different growth rates were compared. All the hepatomas had a significantly higher percentage of RNA in a polysome preparation than did the normal liver, and the polysome preparations from the tumors, with the exception of the Dunning hepatoma which has a high lipid content, gave a greater yield of RNA and protein per gram of wet tissue than the liver did. Heavier polysomes were considerably less prevalent in the tumors than in the liver, and the tumors contained a larger proportion of monomer and dimer ribosomes than the liver did. Evidence is presented that the increased monomer and dimer ribosome population of the hepatomas studied is not an artifact of preparation, but represents the true intracellular distribution. Ribosomes from normal liver and Morris 5123-D hepatoma were readily dissociated by 20 min' treatment with 1.0 mM EDTA, but ribosomes from the Dunning, Novikoff ascites, and McCoy MDAB hepatomas were little affected by such treatment. With higher concentrations of EDTA, the ribosomes from the Novikoff ascites and McCoy MDAB hepatomas broke down and did not form specific subunits as did ribosomes from liver and the Morris 5123-D hepatoma but rather gave rise to a variety of small degradation products. This behavior is ascribed to a higher RNase content of the Novikoff and McCoy MDAB hepatomas. Dunning hepatoma ribosomes were resistant to 4 mM EDTA.


Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. The RNase activity and properties of ribosome and polysome preparations from normal rat liver and some hepatomas have been examined. Polysome and ribosome preparations from the Novikoff, McCoy MDAB, and Dunning hepatomas had considerably higher specific RNase activity than corresponding preparations from normal rat liver, Novikoff ascites, or Morris 5123 hepatomas. The optimum pH of the RNase was approximately 8.5 for all samples tested, and the samples showed no evidence of latent RNase activity when treated with 3 M sodium chloride, EDTA, urea, or p-chloromercuribenzenesulfonic acid. The RNase activity appeared to be associated principally with breakdown products and/or subunits smaller than 80S. In the presence of Mg(++) ions, subunits could reaggregate to form monomer ribosomes indistinguishable from the natural products, but some of the reassociated ribosomes could contain RNase activity which had been bound to the smaller particles. Similar results were obtained with spermine. In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell. When a small amount of crystalline bovine pancreatic RNase was added to partly dissociated ribosomes, the RNase was found only in association with the smaller subunits, and little or no enzyme was taken up by ribosomes or polysomes. The results have led to the conclusion that RNase is not a normal constituent of the ribosome or polysome, but that RNase may become associated with these particulates if dissociation and reassociation take place. Some implications of these findings for the stability of messenger RNA and for the mechanism of its breakdown are discussed.


Studies on dispersion of rabbit olfactory cells.


A variant of lactate dehydrogenase in somatic tissues of pigeons: physicochemical properties and genetic control.


Suitability of collagenase treatment for the radioautographic identification of newly synthesized collagen labeled with 3H-glycine or 3H-proline.


On the fine structural demonstration of glucose 6-phosphatase.


Evidence for the in vitro transfer of defective Rous sarcoma virus genome from hamster tumor cells to chick cells.


Isolation of the nucleic acid of mouse mammary tumor virus (MTV).


Separation of three microbial amino acid polymerization factors.


Lack of evidence for an inhibitory effect of angiotensin on Na+-K+ adenosinetriphosphatase.


Adrenal inhibition in the rat and guinea pig by 2-(p-aminophenyl)-2-phenylethylamine (SK&F 12185).


Action of luteinizing hormone on conversion of ovarian cholesterol stores to steroids secreted in vivo and synthesized in vitro by the pseudopregnant rabbit ovary.


Crisis intervention.

Crisis intervention.


The relation between dental maturation and physiological maturity.


Roentgen and tele-cobalt therapy of cancer of the lung.


The action of adrenalin and glucagon on the metabolism of phospholipids in rat liver.


The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue.


Group relations conference experience.

Group relations conference experience.


Phospholipids of yeast. I. Improvements in analysis by two-dimensional strip-transfer paper chromatography.


A mother-child admission to an inpatient psychiatric unit.


Effect of TSH, acetylcholine, epinephrine, serotonin and synkavite on 32-P incorporation into phospholipids in dog-thyroid slices.


Speaking out... On: what's new?

Speaking out... On: what's new?


Broad horizons of community mental health.


Stability of DNA in synchronized cultures of Tetrahymena pyriformis GL.


Biological activities of 3-isoadenosine.


Resolving conflict through play fantasy.


The two sides of pain. I.

The two sides of pain. I.


Attitudes of Korean and American mental patients toward mental illness and hospitalization.


Metabolic integrity of deoxyribonucleohistones.


Effect of crystallization upon the reactivity of horse liver alcohol dehydrogenase.


Treatment of acute brain syndrome from alcohol with nicotinamide adenine dinucleotide and methaminodiazepoxide.


The interaction of neutralized poliovirus with HeLa cells. I. Adsorption.


Studies on the neutralization of herpes simplex virus. IV. Properties of virus sensitized with complement-requiring neutralizing (CRN) antibody at 37 degrees and 0 degrees.


A comparison of cocal and vesicular stomatitis virus, serotypes New Jersey and Indiana.


Differences between the thermal inactivation of picornaviruses at "high" and "low" temperatures.


Differential effect of actinomycin D on the infectivity of single- and double-stranded poliovirus RNA.


Clomiphene treatment of prolonged secondary amenorrhea associated with pituitary gonadotropin deficiency.


Effects of clomiphene on adrenal cortical steroidogenesis in dogs.


Effect of amantadine hydrochloride on parainfluenza type 1 virus infections in adult volunteers.


Effect of sympathetic nerve stimulation on the uterine vascular bed.


Structure and biosynthesis of the cell wall lipopolysaccharide of Escherichia coli.


Chemical studies on the lipid component of endotoxin, with special emphasis on its relation to biological activities.


The mechanism of pyridine nucleotide synthesis in Ehrlich ascites carcinoma and host liver.


Cationic antibiotics and phospholipase C as tools in the study of phospholipid structure and function. I. Inhibition of the in vitro clotting system by cationic antibiotics.


Cationic antibiotics and phospholipase C as tools in the study of phospholipid structure and function. II. Combined effects of colistin sulfate and phospholipase C on the in vitro blood clotting system.


Factors influencing tetrazole reduction by reduced nicotinamide-adenine dinucleotide in pigeon-heart mitochondria.


Blood sugar regulation in the hagfish, Myxine glutinosa.


Function and cytology of the normal and autotransplanted pars distalis of the hypophysis in the toad Bufo bufo (L).


Hepatoblastoma in infancy. Report of a case.


Studies on zinc deficiency: changes in trace elements and enzyme activities in tissues of zinc-deficient rats. Zinc content of testes, bones, esophagus, kidneys, and muscles was decreased, whereas iron content was increased in the testes of zinc-deficient rats compared to restrictedly fed control rats. Histochemical enzyme determinations revealed reduced activities of certain enzymes in the testes, bones, esophagus, and kidneys. In the testes, lactic dehydrogenase (LDH), malic dehydrogenase (MDH), alcohol dehydrogenase (ADH), and NADH diaphorase; in the bones, LDH, MDH, ADH, and alkaline phosphatase; in the esophagus, MDH, ADH, and NADH diaphorase; and in the kidneys, MDH and alkaline phosphatase were decreased in zinc-deficient rats compared to restrictedly fed controls. Succinic dehydrogenase (SDH) revealed no significant changes under the conditions of our experiments in various groups of rats that were investigated. In a "repleted" group of rats, content of zinc in testes and bones increased significantly, compared to the deficient group. The iron content of the testes decreased after repletion with zinc. In the testes, bones, esophagus, and kidneys, the activities of various enzymes increased after repletion with zinc. Inasmuch as the major manifestations of zinc deficiency syndrome in the rat include growth retardation, testicular atrophy, and esophageal parakeratosis, our results suggest that the content of zinc in the above tissues most likely controls the physiological processes through the formation of zinc-dependent enzymes.


Comparison of the actions of vitamins D2 and D3 in the chick with their retention in serum, liver and intestinal mucosa.


The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs. The effects upon islet hormone secretion of highly purified preparations of secretin and of pancreozymin-cholecystokinin and of a crude gastrin-containing extract of hog antrum have been studied in acutely operated dogs. All three preparations were shown to cause a striking increase in insulin concentration in the pancreaticoduodenal venous plasma after their rapid endoportal injection in anesthetized dogs. With each hormone preparation, the peak in insulin secretion occurred 1 minute after injection, and a rapid decline was observed immediately thereafter. Whereas secretin and gastrin failed to alter significantly the pancreaticoduodenal venous glucagon or arterial glucose concentration, pancreozymin caused a dramatic rise in pancreaticoduodenal venous glucagon concentration, which reached a peak 3 minutes after injection, and hyperglycemia was noted to occur soon thereafter. Endoportal infusion of secretin and pancreozymin for 20 minutes caused responses that were sustained but qualitatively identical to the responses noted after rapid injection of the hormones. The beta-cytotropic effect of secretin was abolished by the infusion of epinephrine. These results could not be attributed to the small degree of contamination of the enteric hormone preparations with insulin or glucagon, and it would appear that secretin, pancreozymin, and probably gastrin have insulin-releasing activity and that pancreozymin has, in addition, glucagon-releasing activity.The demonstration that these three hormones possess insulin-releasing activity suggests that there is in the gastrointestinal tract a chain of betacytotropic hormones from antrum to ileum that is capable of augmenting insulin secretion as required for disposal of substrate loads. It is suggested that the existence of this "entero-insular axis" prevents high substrate concentrations that would otherwise follow ingestion of large meals were the insular response entirely a function of arterial substrate concentration.


Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus.


Efficacy of "Viractin" in preventing respiratory disease.


Metabolism of Mycobacterium leprae separated from human leprosy nodules.


Neoplasms induced by Rous sarcoma virus in New World monkeys.


Leprotic nerve abscesses in northern India.


Intestinal lymphangiography in vivo.

Intestinal lymphangiography in vivo.


Oxidative enzyme activity in Candida albicans.


The treatment of erythema nodosum leprosum with B.663. A controlled study.


A histochemical and fine structure study of the developing rat choroid plexus.


Effectiveness of kanamycin in management of gram-negative septicemia in children with malignant disease.


Kanamycin: its therapeutic record in pulmonary tuberculosis in France and other European countries.


Bacteriology of tuberculosis with special reference to kanamycin and related drugs.


Tetracosactrin.

Tetracosactrin.


The inactivation of pertussis protective antigen, histamine sensitizing factor, and lipolysaccharide by sodium metaperiodate.


Comparison of nicotinamide adenine dinucleotide synthesis by Mycobacterium tuberculosis and Mycobacterium bovis.


The treatment of peripheral nerve lesions of the hand in leprosy.


Changes of nucleoside phosphatase activity in the hypoglossal nucleus during nerve regeneration.


Vesicular stomatitis virus: relationship between strains of the Indiana serotype.


Pyruvic and lactic acid metabolism in muscular dystrophy, neuropathies and other neuromuscular disorders.


Synthesis and reactions of 3,11-beta-dihydroxy-delta-4-androsten-17-one.


Biosynthesis of bacterial glycogen. IV. Activation and inhibition of the adenosine diphosphate glucose pyrophosphorylase of Escherichia coli B.


Biosynthesis of uridine diphosphate D-xylose. 3. Uridine diphosphate D-glucose dehydrogenase of Cryptococcus laurentii.


Studies of the triplet state of proteins by electron spin resonance spectroscopy.


Studies of collagenase activity in periodontal diseases.


Growth behavior of spontaneous hepatoma in C3HO mice.


Quantitative determination of alpha- and gamma-2,4-dinitrophenyl-isomers of alpha,gamma-diaminobutyric acid with an automatic amino acid analyzer as a method of studying N-alpha--N-gamma migration in peptides of alpha,gamma-diaminobutyric acid and polymyxin M.


Changing a hospital environment from a homosexual environment to a heterosexual environment.


Pleomorphic adenoma (mixed tumor) of the palate.


Distant metastases to the jaws: report of four cases.


Studies on metastasis of cancer. XIX. Experimental studies on the mechanism of hematogenous metastasis formation, with reference to the results of repeated intravenous inoculation of small number of tumor cells.


The isolation of parainfluenza. 3. Virus from the testicles of an infertile bull.


Milkers' nodule virus infection and its resemblance to orf.


Microchemical architecture of human isocortex.


Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia.


Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report of 47 cases.


Relationship between viral neurotropism and oncolysis. I. Study of vaccinia virus.


Relationship between viral neurotropism and oncolysis. II. Study of influenza virus.


Brain and spinal cord tumors of children.


Factors influencing serum glycoprotein levels in the mouse and rat.


Incorporation of bicarbonate-14 C into pyrimidines and into ribonucleic acid of the Novikoff ascites tumor cell.


An electron microscopic study of the leukemia virus in AKR and hybrid mice inoculated with ascites passage or tissue-cultured leukemic cells.


Enzymic lesions of nicotinamide adenine dinucleotide biosynthesis in hepatomas and in azo dye carcinogenesis.


Plasma testosterone determination in some cases of hirsutism and virilism of adrenal origin.


Abdominal adenovirosis and appendicitis.


The effect of previous stimulation of the adrenal cortex by adrenocorticotrophin on the function of the pituitary-adrenocortical axis in response to stress. 1. There appear to be at least two peripheral regulators affecting normal physiological adrenal function during repeated stimulation with adrenocorticotrophin (ACTH).2. There is a tachyphylaxis to ACTH if the stimulation of the adrenal gland is frequent. This may be due to alteration or saturation of the trapping mechanism for acceptance of ACTH by the tissue. There also may be inhibitors at the adrenal level. The results obtained could also be explained on the basis of end product inhibition by corticosterone on the process of synthesis or by the presence of a destructive enzyme for ACTH.3. If the amounts of ACTH released or injected are sufficiently great the gland is capable of synthesizing more steroid but adrenocortical dynamics do not allow an immediate release of the steroid into the peripheral circulation. Thereby high levels of steroid in the plasma are maintained for longer periods rather than increased.


Electric injuries to peripheral nerves in animals. A preliminary report.


Characterization of an avian leukosis virus isolate.


Electron transport function of a heat-stable protein and a flavoprotein in the oxidative decarboxylation of glycine by Peptococcus glycinophilus.


The isolation and characterization of a trisaccharide from porcine submaxillary glycoproteins.


Multiple antibodies appearing after massive transfusion of apparently compatible blood.


Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action.


Effects of amino-glutethimide on adrenal function in man.


ACTH stimulation of aldosterone secretion in normal subjects and in patients with chronic adrenocortical insufficiency.


Plasma growth hormone levels in spontaneous hypoglycemia.


Effects of progesterone and estrogen on the sensitivity to angiotensin II.


Anisonucleolinosis in mammalian cell cultures.


Persistent neuropathy following chronic use of glutethimide.


Circulatory responses to angiotensin in man.


The effect of ACTH on the plasma and urinary corticoids in normal elderly persons and in patients with senile psychosis.


Observations on the association of enteric viruses and bacteria with diarrhea.


Histochemical demonstrations of actinomycin-induced changes of certain oxidative and hydrolytic enzymes of rat incisor pulps.


The reaction of DNA with water-soluble carbodiimide and enzyme sensitivity of modified DNA.


Effect of angiotensin on the renal transport of sodium in essential hypertension.


Further observations of the angiotensin vasopressive effect in rabbits.


Bilateral non-chromaffin tympano-jugular paraganglioma.


Islet cell tumor of the pancreas with reversible watery diarrhea and achylorhydraia.


Effect of chronic ethanol feeding on rat liver phospholipid.


Effect of vitamin D3 on the in vitro transport of calcium by the chick intestine.


A revised and more detailed hypothesis for the mechanism of oxidative phosphorylation at the diphosphopyridine nucleotide-flavin level.


Pyridoxal and pyridoxamine phosphate breakdown by an acid phosphatase preparation.


Neuropathy in lymphoblastic leukemia treated with vincristine.


Mycoplasma (PPLO) isolated from Rous sarcoma virus.


Effect of small doses of carrier iodide upon the organic binding of radioactive iodine by the human thyroid gland.


Herpes virus specified ribonucleic acids.


Damage of peripheral nerve associated with orthopedic injuries.


Mucinous adenocarcinoma of the urinary tract.


Visiting nurse consultation in a community psychiatry program.


Clinical pathologic conference No. 2.

Clinical pathologic conference No. 2.


Crisis: the psychiatric nurse intervenes.


Defined media and development of mammalian eggs in vitro.


Herpes simplex encephalitis treated with intravenous idoxuridine.


Community psychiatry, goals, and the psychiatric nurse.


Enzyme histochemistry in experimental diabetes mellitus. 3. Findings on several enzyme activities in pancreatic islet cells of chronic diabetic rabbits.


A student's view of involutional psychosis.


A program of rehabilitation for the chronic female patient.


An attempt to evaluate the steroidogenic activity of synthetic adrenocorticotropic peptides: the circulation method.


International trends.

International trends.


Speaking out. On: the diploma R.N. and further education--a time for reassessment?


Enzyme histochemistry in experimental diabetes mellitus. II. Findings on several enzyme activities in the parenchymal organs, muscular system, intestine, and adrenal gland in diabetic rabbits.


New Jersey's Department of Institutions and Agencies' Nursing Services.


Puromycin potentiation of corticotropin-induced insulin release.


Response of the anterior pituitary-adrenocortical axis to purified CRF.


Effect of renin on adrenocortical sensitivity to ACTH and angiotensin II in dogs.


Liver glycogenesis, glycogen synthetase and adrenal responsiveness of rats exposed to acceleration stress.


Increased ACTH release without increased synthesis.


Comparison of plasma corticotropin concentration in intact and adrenalectomized dogs and cats during hemorrhage.


The two sides of pain. II.

The two sides of pain. II.


Characteristics of the steroid binding site: a method to evaluate sterospecificity of hydrogen transfer by steroid dehydrogenases.


Lysosomes in Tetrahymena pyriformis. I. Some properties and lysosomal localization of acid hydrolases.


The electroencephalogram in advanced senile dementia.


Direct evidence for the binding or compartmentalization of acid-soluble metabolites in oocyte cells.


Gluconeogenesis in mouse kidney cortex. Effect of age and fasting on glucose production and enzyme activities.


Acute hemorrhagic leukoencephalitis of herpes simplex-virus type. Histological and electronmicroscopical findings.


The role of Schwann cells in the formation of onion bulbs found in chronic neuropathies.


Perineural fibroblastomas: their fine structure and biology.


The histopathology of the dilute lethal strain of mice.


Cytochemical and electron microscopic study of a case of Jakob-Creutzfeldt disease.


Ultramicroscopic and histochemical studies of spongy degeneration (van Bogaert and Bertrand type).


Amyloidosis confined to the central and peripheral nervous systems.


Experimental allergic peripheral neuritis studied in vitro.


Effects of isoprenaline treatment of secretory responses and respiratory enzymes of the submazillary gland of the rat.


An immunofluorescence study of the action of antibody in experimental intracerebral infection of mice with Bordetella pertussis.


Superficial hidradenoma and basal-cell carcinoma.


Virilizing ovarian tumor in a 2 1/2-year-old girl.


Metabolism of tritiated vitamin D3 in familial vitamin D-resistant rickets with hypophosphatemia.


Histoenzymatic studies of vessels in hypertensive rats.


Diagnosis of nasopharyngeal angiofibromata by carotid arteriography.


Cylindroma of the right maxillary antrum. Case report.


Studies on urinary phenolic compounds in man. V. Homovanillic and vanillylmandelic acids in children without functional neural tumors.


Histochemical observations in preclinical mouse muscular dystrophy.


The isolation of mitochondria from the colourless alga Prototheca zopfii.


Differentiation of the cell membrane in embryonic chick blood cells.


Intraneural ganglion of the tibial nerve. A case report.


Peripheral neuritis as a complication of infectious mononucleosis. Report of a case.


Cytology of islet tumours and hyperplasias associated with the Zollinger-Ellison syndrome.


The occurrence of granulosa and theca tumours in clinically normal ovaries. A study of 25 cases.


Pregnancy in a case of adrenal hyperplasia. Case report and discussion.


Hormonal activity with ovarian tumours.

Hormonal activity with ovarian tumours.


Radiographic simulation of certain solid tumors of the renal corpus to renal cyst.


Cytomegalovirus infection in an adult.

Cytomegalovirus infection in an adult.


The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle.


The inactivation of foot-and-mouth disease virus at ionic-strength dependent isoelectric points.


Antigenic characteristics of the interaction between Rous sarcoma virus and mammalian cells. Complement-fixing and transplantation antigens.


Potentiation of the action of interferon by extracts of Escherichia coli.


Disaggregation of HeLa cell polysomes after infection with poliovirus.


Study of intracellular SV40 antigens by indirect immunoferritin technique.


Detection of avian leukosis viremia in chicks by transplantation of Bryan strain Rous sarcoma hamster tumors.


Restless legs and orthostatic hypotension in primary amyloidosis.


Prevention of testicular degeneration in alloxanized rats by the use of cortisone.


Electrodiagnostic study of a patient with peripheral neuropathy after nitrofurantoin therapy.


Endogenous nucleotides of mitochondria participating in phosphate transfer reactions as studied with 32P labelled orthophosphate and ultramicro scale ion exchange chromatography.


Fluoride and the metabolism of salivary bacteria.


Strain MC29 avian leukosis virus. Myelocytoma, endothelioma, and renal growths: pathomorphological and ultrastructural aspects.


Lactate dehydrogenase isoenzymes in the diagnosis of human benign and malignant brain tumors.


Ultrastructure of meningeal tumors induced in dogs with Rous sarcoma virus.


Epinephrine potentiation in isolated rabbit aortic strips.


Electron paramagnetic resonance spectra of bone and its major components.


Electron spin resonance in surviving rat tissues.


Complementation between a defective monkey cell-adapting component and human adenoviruses in simian cells.


Foot-and-mouth disease virus-induced ribonucleic acid polymerase in baby hamster kidney cells.


Transplant immunity to polyoma virus-induced tumor cells. IV. A polyoma strain defective in transplant antigen induction.


Heterogeneity of apparently empty poliovirus particles stained with phosphotungstic acid after heating of the virus at "low" temperature.


Observations on patients with cerebral astrocytoma (glioblastoma multiforme) treated by irradiation under whole-body hypothermia.


Carcinogenicity of dimethylnitrosamine in Swiss mice.


Experimental diphtheritic neuropathy in the rat.


Improvements in a method of growing respiratory viruses in organ cultures.


Paravertebral widening in cases of neuroblastoma.


Syntheses and antiviral effect of (amidinocarbamoyl)pyridine derivatives.


Inhibition of the growth of influenza and rubella viruses by amines and ammonium salts.


The use of angiotensin in the assessment of left ventricular function in fixed orifice aortic stenosis.


Peripheral lymphatico-venous anastomoses. Report of two cases.


Effect of angiotensin on urea reabsorption in man.


Adrenocortical response to high dosage ACTH therapy in patients with multiple sclerosis.


Testicular sterols. VI. Incorporation of mevalonate into squalene and sterols by cell-free preparations of testicular tissue.


Some properties of partially purified mammalian adenosine kinase.


Biosynthesis of diphosphopyridine nucleotide. The purification and the properties of diphospyridine nucleotide synthetase from Escherichia coli b.


The localization of acyl coenzyme A-carnitine acyltransferases in rat liver cells.


Muramic acid phosphate as a component of the mucopeptide of Gram-positive bacteria.


Acetyl coenzyme A and acetylcarnitine concentration and turnover rates in muscle and liver of the ketotic rat and guinea pig.


Beef heart malic dehydrogenases. VI. A pH-dependent transition observed in the presence of reduced diphosphopyridine nucleotide.


Studies on the electron transfer system. 68. Formation of membranes as the basis of the reconstitution of the mitochondrial electron transfer system.


Crystalline quinolinate phosphoribosyltransferase. II. Properties of the enzyme.


Mouse brain phosphoserine phosphohydrolase and phosphotransferase.


Identification of alpha,alpha-trehalose 6,6'-dimannosylphosphate and alpha-maltose 1-phosphate of Mycobacteria.


Sugar phosphate phosphohydrolase. I. Substrate specificity, intracellular localization, and purification from Neisseria meningitidis.


Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.


The effect of magnesium ion concentration on the pH optimum of the spinach leaf alkaline fructose diphosphatase.


Androgen production in hypogonadal men.

Androgen production in hypogonadal men.


Serologic survey of man for avian leukosis virus infection.


Some aspects of neuromuscular blockade by polymyxin B.


Therapeutic advantages of an inotropic vasodilator in endotoxin shock.


Malignant hepatoma--controlled therapeutic trials. South African primary liver cancer research group. Initial report.


Cancer of the nose and paranasal sinuses.


Cancer of the stomach.

Cancer of the stomach.


Pancreatoduodenectomy for periampullary cancer.


One-year aetiological study of nondiphtheritic croup.


Nodular theca-lutein hyperplasia of pregnancy (so-called "pregnancy luteoma"). A clinical and pathologic study of 15 cases.


Cancer of the rectum and sigmoid.

Cancer of the rectum and sigmoid.


Postoperative intussusception in infants and children.


Acquired hemolytic anemia. A review of 26 cases, including 5 of the hemolytic-uremic syndrome, with emphasis on the usefulness of steroids in therapy.


The neuromuscular function in patients with malignant tumours. Electromyographic and histological study.


Ethanol-induced hypoglycemia. II. Mechanism of suppression of hepatic gluconeogenesis.


D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis.


Malate dehydrogenases. 3. Alteration of catalytic properties during purification of Bacillus subtilis malate dehydrogenases.


Catalytic properties and specificity of the extracellular nuclease of Staphylococcus aureus.


The reversible dissociation of the alkaline phosphatase of Escherichia coli. 3. Properties of antibodies directed against the subunit.


The biosynthesis of D-apiose in Lemna minor.


Simulation of the action of stimulatory agents on mitochondrial respiration.


Current cancer concepts. Therapeutic vs prophylactic castration.


Field ion microscopical imaging of biomolecules. specimen molecules are protected from field desorption by embedding them in a platinum matrix, with the use of electrolytic codeposition on tungsten tips. High-resolution helium ion images are obtaind when the biomolecules are exposed during gradual removal of surface layers by controlled field evaporation. Structured images of individual molecules of coenzyme I and vitamin B(12)are seen.


Osseous metastasis as the only clinical manifestation of primary cancer of the liver.


Persistence of viral antibodies in patients with chronic bronchitis.


Quantitative evaluation of local blood flow of the adenohypophysis in rats.


Trial of ascorbic acid in prevention of colds.


Tissue phospholipid distribution in adrenalectomized rats.


Immunofluorescent localisation of a growth hormone-like factor in normal and abnormal syncytiotrophoblast.


The effect of cortisone on ribonucleic acid polymerase and ribonuclease during development: coincidental evidence for the identity of ribonucleic acid polymerase with the "operator" gene.


Isolation of parainfluenza-3 virus from water buffaloes in Egypt.


Renal content of renin-like material and pressor reactivity of rats with chronic pyelonephritis.


Effect of blood sugar levels on glycogen content of hypophysis and adrenal glands.


Specificity of a neuraminidase activity of Sendai virus.


Prevention of SV40 virus tumorigenesis by irradiated, disrupted and iododeoxyuridine treated tumor cell antigens.


Influence of vitamin B12 and methionine on levels of folic acid compounds and folate enzymes in rat liver.


Isolation of an unclassified enterovirus from healthy children.


Rhinovirus infection in nursery and kindergarten children. New rhinovirus serotype 54.


Effect of statolon on Friend virus leukemia in mice.


Antiviral substances in plants of the mint family (labiatae). I. Tannin of Melissa officinalis.


Antiviral substances in plants of the mint family (labiatae). 3. Peppermint (Mentha piperita) and other mint plants.


Human cytomegalovirus. Studies on the mechanism of viral cytopathology and inclusion body formation.


Effects of multiplicity of poliovirus infection of HeLa cells upon regulation of DNA synthesis.


Oxidative enzyme content of kidneys from normal and aminonucleoside-nephrotic rats.


Restriction of nonglucosylated T-even bacteriophage: properties of permissive mutants of Escherichia coli B and K12.


On the classification of bovine parainfluenza 3 viruses.


Separation of infectious Varicella-Zoster virus from human embryonic lung fibroblasts.


Histochemical studies of steroid 3-beta-ol dehydrogenases of the human ovaries.


Impetigo contagiosa: etiology, complications, and comparison of therapeutic effectiveness of erythromycin and antibiotic ointment.


Primary chemotherapy for nonmetastatic gestational trophoblastic neoplasms.


The use of methotrexate in the treatment of trophoblastic diseases, especially choriocarcinoma.


Reduplication of nuclear membranes in tissue-culture cells infected with guinea-pig cytomegalovirus.


Correlation of immunology and histopathology of tumors induced by defective SV40-adenovirus hybrids.


Respiratory virus vaccines. VI. Serologic responses to heptavalent vaccine among young children in families.


Corticoid therapy for pretibial myxedema. Observations on the long-acting thyroid stimulator.


Studies on erythropoietic action of angiotensin II.


Erythrocytosis associated with hepatocellular carcinoma.


Maintenance of pregnancy in protein-deficient rats by adrenocortical steroid or ACTH administration.


Inhibition of enzymatic synthesis of epinephrine by low doses of glucocorticoids.


Effects of ACTH on adrenal RNA synthesis.


Inhibition of adrenal protein synthesis by steroids in vitro.


Effect of drugs related to alpha-ethyltryptamine on stress-induced ACTH secretion in the dog.


Adrenal and plasma corticosterone and vitamin A in rat adrenal glands during postnatal development.


Maturation of the circadian rhythm of plasma corticosterone in the rat.


Acid mucopolysaccharide alterations in experimental exophthalmos.


Corticotrophin secretion by ectopic pituitary glands.


Role of the fetal pituitary and adrenal glands in the development of the fetal thymus of the rabbit.


Binding by glutamate dehydrogenase of reduced diphosphopyridine nucleotide. Effects of regulatory ("allosteric") reagents and ionic strength.


An electron spin resonance study of microsomal Fe.


Skeletal muscle lipids. 3. Analysis of the functioning of skeletal muscle lipids during fasting.


Rat liver glutamyl ribonucleic acid synthetase. II. Further properties and anomalous pyrophosphate exchange.


Free adenosine diphosphate as an intermediary in the phosphorylation by creatine phosphate of adenosine diphosphate bound to actin.


Diamine oxidase from pig kidney. Improved purification and properties.


Nicotinamide adenine dinucleotide kinase from Azotobacter vinelandii. I. Purification and properties of the enzyme.


Studies of the acetyl coenzyme A synthetase reaction. V. The requirement for monovalent and divalent cations in partial reactions involving enzyme-bound acetyl adenylate.


Steroid content and synthesis in a virilizing luteoma.


Gonadal malignancy in gonadal dysgenesis: papillary pseudomucinous cystadenocarcinoma in a patient with Turner's syndrome.


Addison's disease in association with idiopathic hypoparathyroidism.


Quantitative analysis of urinary 11-deoxy-17-ketosteroids and pregnanediol by gas-liquid chromatography.


Evaluation of the efficiency of 11-beta-hydroxylation of 11-deoxycortisol in human subjects.


A phenylalanine-lysine-vasopressin test of ACTH release.


Morphine and the incorporation of Pi32 into brain phospholipids of nontolerant, tolerant and abstinent guinea pigs.


Effects of potassium deficiency on experimental renovascular hypertension.


Relapsing polychondritis. Report of a case.


Subcellular distribution and enzyme changes following subacute copper intoxication.


Further experiences with cryosurgery in otolaryngology.


Intratympanic glomus tumors--diagnostic work-up and new surgical approach.


Fungal metabolites as potential carcinogens, with particular reference to their role in the aetiology of hepatoma.


Steroid-sensitive single neurons in rat hypothalamus and midbrain: identification by microelectrophoresis. Minute amounts of Na-dexamethasone-21-phosphate administered by microelectrophoresis to the immediate extracellular environment promptly suppressed electrical activity of 15 out of 115 hypothalamic and mesencephalic neurons, the effect being readily reversible. Such neurons marked with fast green were found to lie in circumscribed areas of the periventricular gray of the third ventricle and aqueduct, and may represent a site of action of adrenocortical steroids in the regulation of corticotrophin releasing factor and/or adrenocortico-tropin secretion by negative feedback.


Angiotensinase activity in pregnant and nonpregnant women.


Paget's disease of the vulva associated with adenocarcinoma developing in a hidradenoma papilliferum.


Studies on Japanese B encephalitis virus vaccines from tissue culture. IX. Human response to a hamster-kidney tissue-culture inactivated vaccine.


Plasma cortisol response to synacthen (beta-1-24 Ciba) at different times of the day in patients with rheumatic diseases.


Fine structure of a melanotic progonoma or retinal anlage tumor of the anterior fontanel.


Virus biographies. II. Growth of herpes simplex virus in tissue culture.


Electron microscopic observations on bronchial epithelium. 1. Annulate lamellae.


Myocardial enzymes in plasmocid-poisoned rabbits. A correlative histochemical and biochemical study.


Viral agents in gastrointestinal disease.


Enterovirus infections of the central nervous system. The present and future of poliomyelitis.


Clinical syndromes in children caused by respiratory infection.


Respiratory disease and the adenoviruses.


Preparation of cell suspensions from tissues using collagenase and hyaluronidase, especially for measuring the electrical charges of surface membranes of mammalian cells.


Normal and 5-bromodeoxyuridine-inhibited development of herpes simplex virus. An electron microscope study.


Vasoconstriction induced by sympathetic stimulation during development of hypertension.


Requirement of calcium ions for the cell fusion reaction of animal cells by HVJ.


Heterotrophic CO2 fixation by a bleached Euglena.


Increased vascular response to angiotensin during ganglionic blockade.


Response to angiotensin infusion before and after adrenalectomy in the rabbit.


Insulin preservation of glucokinase activity in isolated perfused rat liver.


Renin-aldosterone system in endotoxin shock in the dog.


Mechanical activity of vascular smooth muscle under anoxia.


Wilms' tumor: a summary of 25 years of experience before actinomycin-D.


Precocious sexual development; roentgenographic aspects.


In vitro neoplastic transformation of newborn hamster salivary-gland tissue by oncogenic DNA viruses.


Obstruction in cancer of the colon.

Obstruction in cancer of the colon.


Eccrine sweat gland adenoma, clear cell type. A histochemical study.


Optimum conditions for the reaction between uric and phosphotungstic acids in the presence of glycerol-silicate reagent, including a proposed modification of the Archibald method.


Diabetic peripheral neuropathy.

Diabetic peripheral neuropathy.


Diagnostic lymphography.

Diagnostic lymphography.


Phospholipid changes during hepatic injury caused by carbon tetrachloride.


Suppression of tumorous adrenal hyperfunction by aminoglutethimide.


Influence of mineralocorticoids and cations on the inotropic effect of angiotensin and norepinephrine in isolated cardiac muscle.


Cirrhosis and primary cancer of the liver. Comparative study in Tokyo and Cincinnati.


Chemotherapy of germinal tumors.

Chemotherapy of germinal tumors.


Comparative study of methods of administering mitomycin C.


Biological regulation of inorganic pyrophosphate-glucose phosphotransferase and glucose 6-phosphatase. Activation by triamcinolone, in vivo, in the presence of actinomycin D.


Enzyme histochemical studies on the hypothalamus of spontaneously hypertensive rats with special reference to that of rats subjected to various endocrine interferences.


Application of skin allergic test in the diagnosis of adenoviral infections in children.


Prolonged venous catheterization as a cause of sepsis.


A case of temporal lobe epilepsy with some unusual features.


The effect of partial portacaval transposition on the canine liver.


Endocrine function following treatment of pituitary adenoma.


Degeneration of the inner nuclear layer of the retina following lesions of the optic nerve.


Electrophoretic studies on phosphatases from the pancreatic islets of obese-hyperglycaemic mice.


The effect of epinephrine on testosterone production.


On the presence of precorticotrophin--a precursor of corticotrophin in various mammalian hypophyses.


Stimulation of adrenocorticoidogenesis by precorticotrophin after activation.


Effects of beta-1-24 synthetic corticotrophin on reproductive tract and kidneys of immature female mice.


The effect of metabolic inhibitors on the development of respiration in anaerobically grown yeast. 1. Iodoacetate and fluoride did not prevent the development of respiration in aerobically grown yeast. 2. The effect of dinitrophenol suggested that phosphorylation developed simultaneously with respiration in anaerobically grown yeast, but the effect of oligomycin suggested that the phosphorylation and oxidation were not tightly coupled. 3. Inhibitors of electron transport showed that both the respiratory peak and the subsequent respiration were cyanide-sensitive, but the peak respiration was insensitive to antimycin. 4. Of the inhibitors of protein or RNA synthesis tested, only p-fluorophenylalanine inhibited the development of respiration. The results are not consistent with a new synthesis of mitochondria. 5. 2-Phenylethanol inhibited the development of respiration in anaerobically grown yeast and also yeast growth. Other inhibitors of DNA synthesis had no effect on the development of respiration. 6. The relevance of the results to mitochondrial morphogenesis is discussed.


Enzymic hydrolysis of barley and other beta-glucans by a beta-(1--4)-glucan hydrolase. 1. A barley glucan with 68% of beta-(1-->4)-linkages and 32% of beta-(1-->3)-linkages was exhaustively hydrolysed with an Aspergillus niger beta-(1-->4)-glucan 4-glucanohydrolase (EC 3.2.1.4) (Clarke & Stone, 1965b). The hydrolysis products were separated and estimated. 2. The lower-molecular-weight products were identified as: glucose, 1.4%; cellobiose, 11.9%; 3(2)-O-beta-glucosylcellobiose, 45.0%; a tetrasaccharide(s), which was a substituted cellobiose, 16.4%. A series of unidentified higher-molecular-weight products (26.5%) were also found. 3. The identity of the products suggests that the A. niger beta-(1-->4)-glucan hydrolase hydrolyses beta-glucosidic linkages joining 4-O-substituted glucose residues. 4. When an enzyme fraction containing the beta-(1-->4)-glucan hydrolase and an exo-beta-(1-->3)-glucan hydrolase was used, the same products were found, but the higher-molecular-weight products were observed to have only a transient existence in the hydrolysate and were virtually absent after prolonged incubation. It is suggested that these oligosaccharides are resistant to attack by beta-(1-->4)-glucan hydrolase but are partially hydrolysed by the exo-beta-(1-->3)-glucan hydrolase and therefore possess one or more (1-->3)-linked glucose residues at their non-reducing end.


Chromatographic behaviour of rat-liver monophosphoinositide. 1. Chromatography of rat-liver lipids on a column of silicic acid or a mixture of silicic acid and Hyflo Super-Cel, with chloroform-methanol mixtures, gave monophosphoinositide-containing fractions which were invariably contaminated by the presence of nitrogen-containing phospholipids. The behaviour of the inositide was extremely sensitive to column loading and the results with different batches of silicic acid were not reproducible. 2. However, when chromatography on an alumina column was used, the solvent system chloroform-methanol-water (23:23:4, by vol.) completely eluted the neutral lipids, choline-containing phospholipids and phosphatidylethanolamine. An increase of the water content of the solvent to 14% (by vol.) then led to the elution of the monophosphoinositide component, now free from nitrogen-containing phospholipids, but still contaminated by the presence of a phospholipid, which from its properties was taken to be polyglycerophosphatide. 3. Most of the polyglycerophosphatide could be removed from a rat-liver lipid extract by silicic acid chromatography with chloroform-methanol (19:1, v/v). The other phospholipids were then eluted and applied to an alumina column, whereby a monophosphoinositide fraction of much greater purity was obtained. 4. Further purification of the monophosphoinositide was achieved by chromatography on a mixture of silicic acid and cellulose powder. The final product was virtually pure by thin-layer chromatography and gave the expected analysis for monophosphoinositide.