Myopathy associated with pigmentation following adrenalectomy for Cushing's syndrome.


The natural history of cirrhosis. Experience with an unselected group of patients.


Renin, angiotensin, corticosteroids, and electrolyte balance in Addison's disease.


Evidence for the release and depletion of the postsynaptic inhibitory transmitter by pilocarpine.


General base catalysis in the reactions of transfer ribonucleic acid ligases.


Purification and partial characterization of collagenolytic enzymes from Clostridium histolyticum.


Sulfenyl halides as modifying reagents for polypeptides and proteins. I. Modification of tryptophan residues.


Purification, properties and mechanism of interconversion of kidney phosphorylase.


Nicotinamide adenine dinucleotide kinase from Azotobacter vinelandii cells. Reversible inactivation of the enzyme.


Stereospecificity of hydrogen transfer by bovine adrenal 3 beta-hydroxysteroid dehydrogenase.


Pseudocollagenase: a protease from Clostridium histolyticum.


Quantitative analysis of rat liver phospholipids by a two-step thin-layer chromatographic procedure.


The painful tumours of the skin.

The painful tumours of the skin.


Ischemic mononeuropathy and mononeuropathy multiplex in diabetes mellitus.


Control of cardiac-muscle contraction.

Control of cardiac-muscle contraction.


Quantitative determination of phosphatidal ethanolamine and other phosphatides in various tissues of the rat.


Behavior of poliovirus towards dextran sulphate and relationship between this character and other genetic markers.


Paramagnetic anisotropy measurements on acid ferrimyoglobin and ferrimyoglobin fluoride.


Degradation of angiotensin II by a carboxypeptidase of rabbit liver.


Experimental evaluation of the threshold limit of cristobalite--calcined diatomaceous earth.


Specific unmasking of ribosomal proteins under the influence of chelating agents and increased ionic strength.


Differences in turnover between histones and their acetyl N-terminal groups.


The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH.


Enzyme histochemical investigations of the inhibitory effect of zinc on the injurious action of carbon tetrachloride on the liver.


Effect of whole-body gamma-irradiation on the subcellular distribution of proteinases in rat thymus.


Medical problems from Vietnam.

Medical problems from Vietnam.


Residual ethiodol after lymphography in diagnosis of lymphoma.


Chloroquine neuromyopathy.

Chloroquine neuromyopathy.


Release of chronic psychiatric patients into the community.


A case of adult coeliac disease resistant to treatment.


Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck.


Urethan carcinogenesis and nucleic acid metabolism: in vitro interactions with enzymes.


The influence of transplantable rat mammary carcinomas and the Walker carcinoma 256 on the lipid composition of the muscle and liver of the host.


The nucleolar RNA of minimal deviation hepatomas.


The cytochemical localization of glucose-6-phosphatase within the liver of the developing chick embryo.


Particles resembling murine leukaemia virus in New Zealand black mice.


Collagenolytic activity in regenerating forelimbs of the adult newt (Triturus viridescens).


Transfer of defective Rous sarcoma virus genome from Chinese hamster embryonic cells to chicken cells.


Study of antibodies induced in rabbits in the process of viral carcinogenesis.


Possible mechanism for increased purine biosynthesis de novo in Lesch-Nyhan syndrome.


Isolation of encephalomyocarditis (EMC) virus strains in India.


The regulation of fatty acid biosynthesis in rat hepatomas.


Possible functions of hypoxanthine-guanine phosphoribosyltransferase and their relation to the biochemical pathology of the Lesch-Nyhan syndrome.


A phospholipase specific for sphingomyelin from Clostridium perfringens.


An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle.


Lesch-Nyhan syndrome. Pathology and pathologic physiology. Summary.


Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei.


Rational approaches to the treatment of the Lesch-Nyhan syndrome.


5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli.


The detection and identification of intermediates of the pentose phosphate cycle and related compounds.


Lesch-Nyhan syndrome. Management and treatment.


Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin. The present studies demonstrate that iodine depletion increases the sensitivity of the thyroid to the goitrogenic effects of thyrotropin. Iodine depletion was induced by feeding rats a low iodine diet containing propylthiouracil for 10-14 days before hypophysectomy. Accumulation of iodine in the thyroid after hypophysectomy was prevented by continuing the antithyroid drugs in the diet. Doses of thyrotropin as low as 3 mU/100 g of body weight per day produced significant thyroid enlargement in 3-7 days in iodine-depleted rats. Adding propylthiouracil or perchlorate to the diet during treatment with thyrotropin did not reduce or augment the goitrogenic response to thyrotropin in iodine-depleted rats. Increasing the level of circulating iodide also did not reduce the goitrogenic response to thyrotropin. The increased sensitivity of the iodine-depleted thyroid gland may provide an explanation for the development of thyroid enlargement without requiring an increased level of circulating thyrotropin.


Effect of norepinephrine, epinephrine, and angiotensin on blood flow in the internal carotid artery of man. Internal carotid artery blood flow and arterial pressure were measured with a sine-wave electromagnetic flowmeter and a pressure transducer in 22 patients during control period and after the intravenous and intracarotid administration of norepinephrine, epinephrine, and angiotensin. Intravenous infusion of both norepinephrine and angiotensin was accompanied by an increase in cerebral vascular resistance. Administration of norepinephrine, epinephrine, and angiotensin into the internal carotid artery failed to alter blood flow immediately. However, when the systemic blood pressure increased, a concomitant passive rise in blood flow did not occur. Thus, at this time cerebral vascular resistance was significantly increased. It is concluded that these drugs do not have a direct action on the cerebral vessels, but that the increased cerebral vascular resistance after their administration is due to autoregulation or to a combination of autoregulation and reduced arterial carbon dioxide pressure (P(CO2)) secondary to hyperventilation. Similar studies were carried out in the external carotid artery of six patients. Within 10 sec after injection blood flow was markedly reduced, indicating a direct vasoconstricting action on this vascular bed.


Antibody to human follicle-stimulating hormone: cross-reactivity with three other hormones. Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.


Sertoli cell tumor (androblastoma): a case report.


SV40-transformed hamster prostatic tissue: a model of human prostatic malignancy.


Histochemical and histoenzymological studies of tibial growing cartilage in pituitary dwarfism.


Enzyme histochemistry of the mesenteric and dorsal root ganglion cells of cat and squirrel monkey.


A method for the electron microscopic demonstration of cytochrome oxidase in fresh and formalin-prefixed tissues.


Electron microscope studies of phosphatases in the small intestine of Rana temporaria during larval development and metamorphosis.


Enzyme activities as electron microscopic markers of bile and bile thrombi in the study of cholestasis.


Thrombocytopenia in guinea pigs infected by encephalomyocarditis virus (EMC).


Histochemical and histoenzymological study of tibial growing cartilage in Hurler's syndrome.


Comparative physiology of serotonin and melatonin.


Idiopathic facial palsy.

Idiopathic facial palsy.


Pelvic arteriography in invasive trophoblastic neoplasia.


Differences in the growth-promoting effect of normal and peritumoral dermis on epidermis in vitro.


Hereditary hemolytic anemias associated with specific erythrocyte enzymopathies.


Aberrations in pulmonary function due to lymphangiography.


Growth and age-classes in the prairie vole, Microtus ochrogaster.


Organic phosphorus mineralization and phosphatase activity in soils.


Weight of bone in the fetus--a preliminary report.


The properties, developmental formation, and estrogen induction of ornithine aminotransferase in rat tissues.


A method for the separation of cyclic adenosine 3',5'-monophosphate from other adenine nucleotides by high voltage ionophoresis on paper.


Mass enteric live adenovirus vaccination during epidemic ARD.


Endocrine syndromes associated with pancreatic islet cell tumors.


Immunization against respiratory virus infections.


Cyclic 3',5'-adenosine monophosphate phosphodiesterase produced by the slime mold Dictyostelium discoideum. An enzyme that hydrolyzes cyclic ',5'-adenosine monophosphate to 5'-adenosine monophosphate was found in the culture medium of the cellular slime mold Dictyostelium discoidum. The enzymatic activity shows a pH optimum of 7.5, and magnesium is required for maximum activity. The enzyme is not inhibited by caffeine. It has a Michaelis-Menten constant of 2 x 10(-3)M and its molecular weight is around 300,000.


The vascularization of the hypothalamic-hypophyseal region of the Eastern Brook Trout, Salvelinus fontinalis.


The effects of essential fatty acid deficiency on the skin of the mouse.


Observations on the growth andregression of Rous sarcoma in rats and mice of a non-inbred strain.


A comparative study of arteriography and scintillation scanning in space-occupying leions of the liver.


The mucosal diseases in the Netherlands.


Avian leukosis.

Avian leukosis.


Response of "prolactin-secreting" cells of Tilapia mossambica to environmental salinity.


Effects of corticosterone on oxidative metabolism in different tissues of the rat.


Helminths as vehicles and synergists of microbial infections.


Metabolism and blood levels following infusion of a radioactive analog of angiotensin.


Amphotericin B therapy in the treatment of presumed histoplasma chorioretinitis. A further appraisal.


Deterministic nature of baroreceptor firing.


Kinetics of renin-angiotensinogen reaction in plasma of normal and nephrectomized rats.


Mucoepidermoid carcinoma of the parotid gland.


Hemagglutinating activity of enteroviruses recovered in two primary cell lines and a stable line. A microhemagglutination technique was used to detect hemagglutinating properties of enteroviruses recovered in two primary cell lines, monkey kidney (MK) and human amnion (HAm), and in a continuous cell line, human embryonic lung (HEL). During a 3-year period, 1,528 isolations of enteroviruses were tested for hemagglutinating activity and hemagglutination inhibition response; 96.3% of the viruses were also identified by virus neutralization tests. Enteroviruses recovered in HEL were far less likely to develop hemagglutinins than viruses isolated in MK or HAm. Of the enteroviruses known to agglutinate human type O cells, 77.8% of the primary viral isolates from MK, 62.1% of the isolates from HAm, and 20.3% of the isolates from HEL exhibited this property. An additional 8.1% of the isolations obtained in HEL hemagglutinated human cells after a single passage in MK. The microhemagglutination technique using microtiter equipment was simple to perform, saved time and valuable typing sera, and helped to obtain identifications rapidly.


Postabortal septicemia due to Clostridium welchii. Treatment with exchange transfusion.


Experimental opacification of the substernal lymph nodes in animals.


Angiotensin-infusion test. Correlation with renin activity in peripheral venous blood.


Clear cell hidradenoma of the breast.

Clear cell hidradenoma of the breast.


Primary hepatocellular carcinoma in three male siblings.


Ultrastructure of the chondroid regions of benign mixed tumor of salivary gland.


Survival in males with surgically treated localized cancer of the lung.


The development defects associated with neuroblastoma--etiologic implications.


Mesenchymal hamartoma of the liver.

Mesenchymal hamartoma of the liver.


Effect of fluoride on the metabolic activity of thyroid slices.


Acute effects of angiotensin-II-amide on aldosterone and corticosterone secretion by morphine-pentobarbital treated rats.


Effects of small doses of thyroid hormones on thyroid weight in hypothyroid rats.


Inhibition of adrenal cortical secretion by amino-glutethimide in dogs.


The management of facial palsy.

The management of facial palsy.


Marmoset liver organ culture infected with herpes virus.


Brachial plexus avulsion. A review of diagnostic procedures and report of six cases.


Nerve root conduction studies during lumbar disc surgery.


Electrophoretic mobility of isolated nuclei from rat ascites hepatoma cells and normal liver cells.


Examination of fibres in beer.

Examination of fibres in beer.


Photoparamagnetism in solid nucleic acid-cationic dye complexes.


Diffusion of antibiotics from plasma into prostatic fluid.


Tumour production in adult mice by syngeneic embryonic cultured cells containing the incomplete Rous virus.


Influence of efferent fibres on a receptor.


Electron spin resonance in organic chemistry. Determination of structure and conformation of paramagnetic substances is demonstrated.


Virology: United States-Soviet Health Exchange visit 1967.


Spinal cord lesions and rehabilitation: Review of cases discharged from the Duke Medical Center, Neurosurgical Division (1959-1964).


Diagnostic value of the simultaneous determination of urinary free and conjugated cortisol in Cushing's syndrome.


Monkeypox: experimental infection in chimpanzee (Pan satyrus) and immunization with vaccinia virus.


Current problems in the use of the oncolytic drugs.


Sites of impulse formation within the atrioventricular junction of the rabbit.


Tissue fractionation and catecholamines. II. Intracellular distribution patterns of tyrosine hydroxylase, dopa decarboxylase, dopamine-beta-hydroxylase, phenylethanolamine N-methyltransferase and monoamine oxidase in adrenal medulla.


Changes in sodium balance and hemodynamics during development of experimental renal hypertension in dogs.


Effects of sympathetic nerve stimulation on the pulmonary arterial tree of the isolated lobe perfused in situ.


The correlation of the fasting serum tyrosine level to the clinical status of patients with rheumatoid arthritis.


Endocrine factors in congestive heart failure.


A rapid radioimmunoassay for human placental lactogen. Application to normal and pathologic pregnancies.


Ambiguous genitals in a female infant associated with luteoma of pregnancy. Report of a case.


Glomus jugulare tumors. I. Historical background.


Effect of an intrauterine contraceptive device on biochemical composition of uterine fluid.


Treatment of malignant tumors of minor salivary glands.


The kinetics of cyanide and fluoride binding by ferric horseradish peroxidase.


Evidence for an acid-catalyzed alpha,beta epimerization in pyridine nucleotides.


Mechanisms of the primary acid modification reaction of reduced diphosphopyridine nucleotide models.


On the localization of alkaline phosphatase and cyclic phosphodiesterase in Escherichia coli.


Inosine 5'-phosphate dehydrogenase. Kinetic mechanism and evidence for selective reaction of the 6-chloro analog of inosine 5'-phosphate with a cysteine residue at the inosine 5'-phosphate site.


Purification and properties of the luciferase and of a protein cofactor in the bioluminescence system of Latia neritoides.


A simple method for isolating highly purified yeast phenylalanine transfer ribonucleic acid.


Spin-labeled hemoglobin subunits.

Spin-labeled hemoglobin subunits.


Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene.


Kinetics of coupled enzymes. Creatine kinase and myosin A.


Fatty acid biosynthesis. IV. Properties of acetyl-CoA carboxylase in lactating-rabbit mammary gland.


Effect of sphingomyelinase from Clostridium perfringens on the metabolic activity and phospholipid composition of thyroid slices.


Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis.


Separation of sphingosine, dihydrosphingosine and phytosphingosine by chromatography on columns of silica gel.


Factors affecting the synthesis of 2,3-diphosphoglycerate in hemolysates of human erythrocytes.


Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain.


The concentration of HCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system.


Effect of splenectomy on hepatic tumorigenesis. A morphological study.


A study of the interdependence of red cell and bone marrow stem cell populations.


Effect of angiotensin on the response to noradrenaline and sympathetic nerve stimulation, and on 3H-noradrenaline uptake in cat mesenteric blood vessels.


The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat.


Angiotensin in the analysis of the intrinsic nerve supply of isolated intestines.


Removal of angiotensins from the systemic circulation.


Effectiveness of radiation therapy in the management of sarcoma of the soft somatic tissues.


Ultrastructural studies in Wilms's tumor.


Measurement of testosterone and 17-ketosteroids in plasma by the double isotope dilution derivative technique.


C3H-Avy--a high hepatoma and high mammary tumor strain of mice.


Susceptibility of mammary tissues of different strains of mice to tumor development.


Auditory detection and perception in normal man and in patients with adrenal cortical insufficiency: effect of adrenal cortical steroids. Auditory detection thresholds for sinusoidal tones and various tests of auditory perception were determined in 12 patients with adrenal cortical insufficiency (seven with Addison's disease and five with panhypopituitarism) and compared to those in normal volunteers. In adrenal cortical insufficiency auditory detection sensitivity was significantly more acute than normal, and judgments of loudness and of the contralateral threshold shift were made at levels more than 20 db below those of normal subjects. Thus both the lower and the upper limits of the dynamic auditory range are significantly decreased in these patients. Speech discrimination ability of the patients was significantly impaired as was their difference limens, their alternate binaural loudness balances, and their ability to localize tones in space. Treatment of the patients with deoxycorticosterone acetate decreased serum potassium concentration, raised serum sodium concentration, and produced gains in body weight but did not alter auditory detection or perception. Treatment with prednisolone or with maintenance doses of carbohydrate-active steroids returned auditory detection and perception to normal in every patient tested. The inability of the untreated patients to perform the various auditory perception tasks indicates that they have a defect in their ability to integrate incoming sensory stimuli. This defect may be related to the alteration in the timing of transmission of neural impulses along axons and across synapses which occurs in these patients when their carbohydrate-active steroid is removed. This decreased integrative capacity occurs at the same time that they are able to detect many types of sensory stimuli significantly better than normal subjects. This interrelationship between increased detection sensitivity and decreased perceptual ability is dependent upon the absence of carbohydrate-active steroids, for when these steroids are replaced both detection sensitivity and perceptual ability revert to normal.


Influence of mammary tumor virus on the tumor-producing capabilities of nodule outgrowth free of mammary tumor virus.


Propagation of the mammary tumor agent (Bittner virus) in the absence of mammary glands in mice.


Time of appearance of viral activity in red blood cells of mice infected naturally or artificially with mammary tumor virus.


Biological properties of B particles from C3H and C3Hf mouse milk.


Immunology of the mouse mammary tumor virus (MTV). Electron microscopic studies of interaction between MTV and specific antibody in immunodiffusion.


Electron microscopic and bioassay studies of milk from mice of high and low mammary-cancer and high and low leukemia strains.


The effects of some anti-oestrogens on the deciduoma reaction and delayed implantation in the mouse.


Single versus multiple dose dactinomycin therapy of Wilms's tumor. A controlled co-operative study conducted by the Children's Cancer Study Group A (formerly Acute Leukemia Co-operative Chemotherapy Group A).


The hypothalamic-pituitary axis.

The hypothalamic-pituitary axis.


Intermittent steroid therapy. Its effect on hypothalamic-pituitary-adrenal function and the response of plasma growth hormone and insulin to stimulation.


Prevention of metastases.

Prevention of metastases.


The fine structure of an intraoral granular-cell myoblastoma.


(Na+K+)-activated ATPase in kidney cell membranes of normal and methyprednisolone-treated rats.


The presence of K+dependent phophatase in intestinal epithelial cell brush borders isolated by a new method.


Effects of ATP and Na+ on a K+-activated phosphatase from red blood cell membranes.


Stimulatory effect of Na+ and ATP on the release of acetylcholine from synaptic vesicles.


Inhibition of partial reactions in bacterial photosynthesis by 3-(3,4-dichlorophenyl)-i, i-dimethylurea.


Physical state of cytochrome oxidase. Relationship between membrane formation and ionic strength.


The role of ammonium sulfate precipitation in the removal of substances which interfere with enzymatic hydrolysis of conjugated estrogens in pregnancy urine.


Visible, optical rotatory dispersion, and paramagnetic resonance spectra of the L-histidine--cu(II)--L-threonine complex.


Electrodiagnosis of polyneuropathy.

Electrodiagnosis of polyneuropathy.


The purification and properties of guanosine diphosphate glucose pyrophosphorylase of pea seedlings.


Endocrine disorders of the pancreas.

Endocrine disorders of the pancreas.


Influence of pyrophosphate on the crystallisation of uric acid and magnesium ammonium phosphate and its implications in phosphate therapy for urolithiasis.


Serological data on the distribution of some enteroviruses in Bulgaria.


Electron microscopy of hepatic cell lesions induced by electrocution.


Electron-spin-resonance evidence for interaction of protons with Mo(V) in reduced forms of xanthine oxidase.


Further studies on the oxidation of extramitochondrial reduced nicotineamide-adenine dinucleotide in Landschuetz ascites tumor cells.


Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines.


Studies on the chemical isomerization of vitamin D. IV. Identification of vitamin D2 and its related compounds by thin layer chromatography.


Newer antiviral agents--comparative assays in vivo and in vitro.


A human interferon that crosses the species line.


The effect of lincomycin on neuromuscular transmission.


Hemopexin of rabbits.

Hemopexin of rabbits.


Changes in phosphate content associated with "green ear" disease of Bajra.


Acute viral respiratory infections in Switzerland 1967.


Esophageal varices in the absence of cirrhosis, Incidence and characteristics in congestive heart failure and neoplasm of the liver.


Attempts to relate bovine papilloma virus to the cause of equine sarcoid: immunity to bovine papilloma virus.


Vaccination of beef calves before weaning with a live-virus bovine myxovirus parainfluenza-3 vaccine.


pH resistance of foot-and-mouth disease virus and its complement-fixing antigen.


Studies on Chikungunva virus. 3. Infective ribonucleic acid from partially purified virus: its biological assay and some of its basic characteristics.


Studies on lysosomes. IX. Localization of bacteriophages and thorotrast and their inflammatory properties.


Endocrine relations between mother and fetus.


Modification of the transfer function of proline transfer ribonucleic acid synthetase by temperature.


Separation and detection of biogenic amines by thin-layer chromatography. Micro-analysis of tissue amines and of enzymes involved in their metabolism.


Peroral infection and resistance to reinfection with encephalomyocarditis virus in the mouse.


Virologic aspects in studies of Japanese and tick-borne encephalitis.


Correlation between clinical pattern and pathological findings in Cushing's syndrome.


The dynamic behaviour of proteins during catalysis.


Peripheral brachial neuropathy secondary to lightning shock with recurrent fractures of the 5th metacarpal bone. Case report.


Current concepts of burn injury. II.

Current concepts of burn injury. II.


The anterior and posterior meningeal branches of the vertebral artery.


Conservative (supportive) treatment of severe ulcerative colitis. Methods and results.


Considerations on the permanence of psychiatric rehabilitation.


Facilitated proton transfer in enzyme catalysis. It may have a crucial role in determining the efficiency and specificity of enzymes.


Comparative pathogenicity of vesicular stomatitis virus and its plaque type mutants.


Improved techniques for the detection of foot-and-mouth disease virus in carrier cattle.


Histopathological and virological studies on monkeypox.


The experimental production of a formalin-killed Japanese encephalitis virus vaccine from porcine kidney cell cultures.


Interaction of interferon with chick embryo cells.


Inhibition of biliary secretion by icterogenin and related triterpenes. I. Effect of icterogenin, rehmannic acid and oleanolic acetate on liver mitochondria in vitro.


Effects of piercidin A on the metabolism of isolated adipose cells.


Study on the effect of 3-acetylpyridine on blood glucose concentration.


Site of foot-and-mouth disease virus-ribonucleic acid synthesis and some properties of its double-stranded ribonucleic acid.


Difference in binding of 2-acetylaminofluorene to rat liver deoxyribonucleic acid and ribosomal ribonucleic acid in vivo.


A 'short1 feedback mechanism controlling FSH secretion.


Hydrogen addition radicals of stilbestrol, hexestrol, and benzestrol.


Histochemical localization of ACTH and TSH in the human hypophysis.


Studies on the histochemical distribution of oxidative enzymes in sympathetic ganglion cells of rat.


Studies on the histochemical distribution of phosphatases in sympathetic ganglion neurons of rat.


The thymus of the adult stressed dog, a predominantly epithelial organ. A histological, histochemical and statistical study.


Preparation of cytomegalovirus immune serum in rabbits with alkaline-extracted virus.


Natural history of Sendai virus infection in mice.


Characteristics of vaccine-induced and natural infection with adenovirus type 4 in naval recruits.


A community study of respiratory infections in the tropics. II. The spread of six rhinovirus isolates within the community.


The role of a neighborhood service center in community mental health.


A community study of respiratory infections in the tropics. 3. Introduction and transmission of infections within families.


Electron microscopic studies of capillaries in experimental chronic granulomas.


A case of ovarian arrhenoblastoma.

A case of ovarian arrhenoblastoma.


Synthesis, biological activity., and metabolism of 22,23-3H vitamin D4.


Inhibition and release of respiration in particles from Alcaligenes faecalis.


Investigation of the component reactions of steroldemethylation: preparation and properties of yeast demethylase activity.


Transference of triplet state excitation energy from tyrosine to tryptophan. I. Amino acids in simple and mixed solutions.


Thyroid hormone action on mitochondria. II. Effect of dinitrophenol.


Studies on chemical mechanisms of the action of neurotransmitters and hormones. I. Relationship between hormone stimulated 32P incorporation into phosphatidic acid and into phosphatidylinositol in pigeon pancreas slices.


Curdlan: a bacterial gel-forming beta-1,3-glucan.


Studies on chemical mechanisms of the action of neurotransmitters and hormones. II. Increased incorporation of 32P into phosphatides as a second, adaptive response to pancreozymin or acetylcholine in pigeon pancreas slices.


L-O-Methylthreonine--synthesis and mode of action as an isoleucine antagonist.


Subcellular distributions and properties of rat liver phosphodiesterases.


The mechanism of liver alcohol dehydrogenase.


Investigations on the biogenesis of chlorophyll a. I. Purification and mass spectra of maleimides from the oxidation of chlorophyll and related compounds.


Reduction of hydroxylamine by rat liver mitochondria.


Glomus tumor of the stomach. Report of a case.


Neurology of depression.

Neurology of depression.


Effects of avenaciolide on lipolysis and on glucose, amino acid and palmitic acid metabolism in isolated adipose cells.


The chronic patient in the community. A two-year follow up of 338 chronic patients.


The mental health services in the Soviet Union.


Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states.


Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing.


Biosynthesis of long chain fatty acids by subcellular particles of mature brain.


Controle of the metabolism and lipolytic effects of cyclic 3',5'-adenosine monophosphate in adipose tissue by insulin, methyl xanthines, and nicotinic acid.


Vitamin D-dependent calcium-binding protein. Response to some physiological and nutritional variables.


Vitamin D-dependent calcium-binding protein. Purification and some properties.


Studies on cytochrome c peroxidase. XI. A crystalline enzyme reconstituted from apoenzyme and manganese protoporphyrin IX.


Class separation of flavour volatiles by liquid chromatography on silica gel at 1 degree.


Control of bleeding during surgery on vascular tumors of the head.


The binding of noradrenaline to monophosphoinositide: in vitro studies.


Ultrastructure of a so-called granular cell myoblastoma.


A skeleton which was not considered as a criminal case.


Type II syndactyly.

Type II syndactyly.


Evaluation of deficiency of 21-hydroxylation in patients with congenital adrenal hyperplasia.


Planography during pneumoencephalography. The diagnosis of lesions affecting the optic pathways.


Clear cell hidradenoma of the eyelid.

Clear cell hidradenoma of the eyelid.


The chronology of primary herpes simplex infection of the eye and adnexal glands.


Ultrastructural studies on nucleic acids of nucleolar granular components in Novikoff hepatoma cells.


Studies on serum complement lvel in rabbits bearing tumours of Shope papilloma-carcinoma complex.


Immunosuppressive effects of macrophage antiserum.


Detection of antigens of a new diethylnitrosamine-induced transplantable hepatoma by delayed hypersensitivity.


Observations on the nature of a genetic cellular resistance to avian tumor viruses.


Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis.


Antigenicity of a new diethylnitrosamine-induced transplantable guinea pig hepatoma: pathology and formation of ascites variant.


Infection of the vulva and cervix with a genital strain of herpes simplex virus.


Cytomegalic inclusion-body disease.

Cytomegalic inclusion-body disease.


Agglutinating antibodies in the sera of chickens with regressing Rous sarcomas.


Interactions between chlorophyll and water in the solid state: electron spin resonance.


Rhabodomyosarcoma simulating nasopharyngeal angiofibroma.


Transformation of animal cells by oncogenic DNA viruses.


Acute necrotizing haemorrhagic encephalitis presenting clinically as a space-occupying lesion. A clinico-pathological study of six cases.


Effects of reserpine, furosemide and hydrochlorothiazid on modifications of the pressure response to bradykinin and angiotensin provoked in the rat by guanethidine.


The interaction between angiotensin and sympathetically-induced vasoconstriction in the isolated perfused central ear artery of the rabbit.


The conversion of angiotensin I to angiotensin II in vivo.


A comparison of the concentrations of steroids in the adrenal gland with the rates of their secretion.


Evidence against the participation of acetylcholine in transmission at sympathetic adrenergic nerve terminals.


Intercalation into DNA.

Intercalation into DNA.


Interactions of L-glutamic acid, gamma-aminobutyric acid and Pyridoxal-5'-phosphate at ehe neuronal level.


[Synthesis of glucuronic acid "in vitro" and "in vivo" after whole body irradiation in rats].


Changes in circulating lymphocytes induced by the administration of ACTH in cocks.


Liver biopsy in human leptospirosis: a light and electron microscopy study.


Antibody formation in cell cultures. 1. Membrane cultures of lymphoid cells: a system for studies of long term secondary antibody responses to poliovirus.


Cancer of the pancreas.

Cancer of the pancreas.


Plasma renin activity and angiotensin pressor dose in hypertension correlation and diagnostic implications. Data obtained from 65 hypertensive patients showed a clear-cut positive correlation between peripheral plasma renin activity and the pressor response to exogenous angiotensin II (r =+0.75). For the various causes of hypertension, the mean values of plasma renin concentration were found to correspond closely to the mean values of the angiotensin pressor dose. In individual cases, however, the pressor dose of angiotensin was not found to be a reliable gauge of peripheral venous renin activity.It was impossible to establish a causal diagnosis from the results of the angiotensin infusion test or the renin level in peripheral blood under normal conditions. If, however, determinations are carried out on the renal venous effluent with sodium restriction and with the patient in the upright position the renin level is very valuable both in the diagnosis of renovascular hypertension and in predicting the probable outcome of surgical treatment.


The chromosomes of forty-two primary Rous sarcomas of the Chinese hamster.


Early external auditory canal tumors.

Early external auditory canal tumors.


Inclusion compounds of cyclodextrins.

Inclusion compounds of cyclodextrins.


Incorporation of methyl groups by viral and cellular RNA of HEp 2 cells after poliovirus infection.


Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers.


Action of guanidine on the replication of poliovirus RNA.


Induction of cellular mRNA synthesis in BSC-1 cells infected by SV40.


Isolation and structure of the nucleocapsid of HVJ.


Density difference of DNA of human herpes simplex viruses, types I and II.


Dental silicate cements. VI. Infrared studies.


Melanocyte-stimulating and corticotrophic activities in human foetal pituitary glands.


Hamartoma of the tongue. Report of a case.


Granular cell schwannoma (myoblastoma). Report of cases.


Nicotinamide adenine dinucleotide in the treatment of chronic schizophrenic patients.


Juvenile nasopharyngeal fibroma in female adult. Report of a case.


Bacitracin and polymyxins.

Bacitracin and polymyxins.


Renal tumours and hypertension.

Renal tumours and hypertension.


Infusion of liver tumours.

Infusion of liver tumours.


Herpes encephalitis.

Herpes encephalitis.


Experimental chemotherapy of tuberculosis.


Vasopressor drugs and catecholamines.

Vasopressor drugs and catecholamines.


Glucagon.

Glucagon.


Adipose tissue dynamics and regulation, revisited.


Deterioration of esophageal peristalsis in patients with alcoholic neuropathy.


Effect of the intestinal bacterial flora on acute gastric stress ulceration.


Diagnosis and management of the megacolon of ulcerative colitis.


Discharged psychiatric patients' visits to a former treatment center: a nursing dilemma.


Lay literature as an adjunctive teaching tool.


Acute infectious lymphocytosis. An etiologic and epidemiologic study of an outbreak.


Effect of glucagon on heart.

Effect of glucagon on heart.


Conflict: the nurse as therapist and researcher.


Hong Kong and its millions of refugees.

Hong Kong and its millions of refugees.


A study of the effects of remotivation on social competence, social interest and personal neatness.


Induction of antibodies to porcine ACTH in rabbits with nonsteroidogenic polymers of BSA and ACTH.


International trends. WHO in Europe.

International trends. WHO in Europe.


Interferon production in cell lines derived from patients with infectious mononucleosis.


The student nurse.

The student nurse.


Speaking out. on: dealing with irresponsible acting-out behavior in these United States.


Isolation of human enteroviruses from beagle dogs.


Phospholipase activity of the delta hemolysin of Staphylococcus aureus.


Rare earth metals and soft-tissue calcification.


Presence of antibodies to simian virus 40 (SV40) T antigen in rhesus monkeys infected experimentally or naturally with SV40.


Psychiatric drugs & trends. The "Brand Name" game.


Immunofluorescent study on early virus-cell interaction in Shope papilloma in vitro system.


The incidence of complement-fixing antibodies to herpes simplex and herpes-like viruses in man and rhesus monkeys.


Criteria for physiological stress produced by increased chronic acceleration.


The preparation and characterization of large oligoribonucleotides.


Experimental approaches to the determination of the nucleotide sequences of large oligonucleotides and small nucleic acids.


Ionic interaction of sulfatide with choline lipids. Aqueous systems of sphingomyelin-sulfatide and lecithin-sulfatide were compared with aqueous systems of the individual lipids. The acid capacity of the mixed lipids increased, a result of the formation of an ionic bond between the sulfate of one molecule and the positive nitrogen of the other, making the phosphate available for direct titration. Cholesterol reduces this ionic interaction, probably because of the increased spacing of the ionized groups.


Vinomycin I. The amino acid sequence of viomycin.


The structure of regular viruses in relation to their subunit amino acid composition.


The fine structure of vesicular stomatitis virus.


The nucleic acid of the parainfluenza virus SV5.


Production of a potent complement-fixing murine leukemia virus-antiserum from the rabbit and its reactions with various types of tissue culture cells.


Productive and abortive infections of simian and nonsimian cells with a simian adenovirus SV15. II. Viral biosynthesis and effects of chemical inhibitors.


Ornithine transcarbamoylase in Shope papilloma.


Changes in circulating lymphocytes induced by the administration of ACTH in cocks.


High blood pressure and oral contraceptives. Changes in plasma renin and renin substrate and in aldosterone excretion.


The diagnosis of trophoblastic tumours of testis.


Treatment of pseudomonas infection of the rabbit cornea. Comparative study.


Acute and chronic effects of iodide on thyroid radioiodine metabolism in iodine-deficient rats.


Analysis of the Koritz-Hall hypothesis for the regulation of steroidogenesis by ACTH.


In vitro neoplastic transformation of uveal and retinal tissue by oncogenic DNA viruses.


Studies on the effect of bacterial endotoxin on primary herpetic keratitis.


Effect of age on the crystallinity of collagen. II. Density, reactivity, and composition.


Metabolism of D-fructose in Aerobacter aerogenes: analysis of mutants lacking D-fructose 6-phosphate kinase and D-fructose 1,6-diphosphatase. The relative significance of the pathways for the conversion of d-fructose to d-fructose 1,6-diphosphate via d-fructose 1-phosphate or d-fructose 6-phosphate in Aerobacter aerogenes PRL-R3 was assessed by observing growth patterns of mutants lacking either d-fructose 6-phosphate kinase or d-fructose 1,6-diphosphatase. The mutant lacking d-fructose 6-phosphate kinase grew well on d-fructose or glycerol but not on d-glucose, whereas the mutant lacking d-fructose 1,6-diphosphatase grew on d-glucose but not on d-fructose or glycerol. The data indicate that the pathway of d-fructose metabolism is primarily through d-fructose 1-phosphate rather than d-fructose 6-phosphate.


The effect of hypophysectomy on the aging of collagen fibers in the tail tendon of the rat.


Purification and properties of L-alanine dehydrogenase from Desulfovibrio desulfuricans. The l-alanine dehydrogenase from cell-free extracts of Desulfovibrio desulfuricans was purified approximately 56-fold. The Michaelis constants for the substrates of the amination reaction and the pH optima for the reactions catalyzed by this enzyme closely agree with those reported for other l-alanine dehydrogenases. Pyruvate was found to inhibit the amination reaction. The enzyme was absolutely specific for l-alanine and nicotinamide adenine dinucleotide. Its sensitivity to para-chloromecuribenzoate suggests that sulfhydryl groups may be necessary for enzymatic activity. These extracts also contained a nicotinamide adenine dinucleotide phosphate-specific glutamic dehydrogenase which was separated from the l-alanine dehydrogenase during purification.


Preparation and screening of aminoacridines for induction of lung tumor fluorescence in rats.


A treatment of corticosteroid-dependent lepromatous patients in persistent erythema nodosum leprosum. A clinical evaluation of G.30320 (B663).


Malabsorption of iron secondary to iron deficiency.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 35-1968.


Free radical yields in polytetrafluoroethylene as the basis for a radiation dosimeter.


Effect of pH on the formation and intermolecular transfer of radiation-induced unpaired spins in frozen aqueous mixtures.


Role of intermolecular reactions in the formation of secondary radicals in proteins irradiated in the dry state.


Cell proliferation: enhancement by extracts from cell surfaces of polyoma-virus-transformed cells. Dispersion of confluent monolayers of BHK21 cells with ethylenediaminetetraacetate yields a material that inhibits cell proliferation, whereas identical extraction of polyoma-virus-transformed cells provides material which enhances cellular proliferation. The material was partially characterized.


Effect of mesenteric traction on peripheral vascular resistance.


Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Chick and mouse cell monolayers treated with interferon were significantly protected from destruction by toxoplasma. The results suggest that fewer numbers of organisms were released from interferon-treated cells. Interferons were uniformly more active in a viral assay than in a toxoplasma assay, and they had the same properties in both assays. The data suggest that interferon activity may be directed against organisms phylogenetically higher than viruses.


Studies on the histochemical distribution of glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, beta-glucuronidase and glucosan phosphorylase in olfactory bulb of rat.


Vasopressin test for corticotrophin release in man.


The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.


Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex.


Inhibition of activated lipolysis by acidosis.


The effect of hyperbaric oxygen on the prevention of experimental C1. Welchii infection.


Histochemical studies of glucose-6-phosphatase activity in the early proliferative stage of liver carcinogenesis.


Changes in the amount of adrenergic transmitter in the female genital tract of rabbit during pregnancy.


Glucose metabolism and response to insulin of isolated fat cells and epididymal. fat pads.


Effect of adrenaline, noradrenaline, angiotensin and renal nerve stimulation on intrarenal distribution of blood flow in dogs.


Considerations on the cause of disappearance of the adrenergic transmitter in uterine nerves during pregnancy.


Control of brain serotonin and norepinephrine by specific neural systems.


Serotonin participation in the vagal inhibitory pathway to the stomach.


Stimulation-induced release of serotonin.


Discussion of stimulation-induced release of serotonin.


Evidence for an excitatory transmitter role of serotonin in molluscan central synapses.


Discussion of evidence for an excitatory transmitter role of serotonin in molluscan central synapses.


Serotonin effects on central neurons.

Serotonin effects on central neurons.


Granular cell myoblastoma of the breast.


Necrotizing infections of subcutaneous tissue and fascia.


Serological studies of the T and tumor antigens of the oncogenic simian adenoviruses. Tumor-specific antigens and antisera were prepared for eight of the oncogenic simian adenoviruses. Complement-fixation tests revealed three distinct serological subgroups. This grouping was maintained in studies of virus-infected cells (T antigens) although high titered preparations were obtained for only the major subgroup I. The current grouping is as follows: (I) SV1, SV11, SV25, SV33, SV34, SV38; (II) SV20, SV23; (III) SA 7. Antigens from each subgroup were rapidly inactivated at 56 C, and group II and III antigens were also markedly inactivated at 37 C. One of the tumors (SV1) also contained SV40 T antigen, suggesting origin from a simian adenovirus-SV40 "hybrid."


Effect of statolon-induced interferon on antibody formation. The effect of statolon-induced interferon on immune response was investigated. Young adult Swiss albino mice were immunized with chicken red blood cells or infectious mengovirus. The red blood cells were injected three times and the virus twice at 2-week intervals, with or without treatment with statolon 24 hr before the inoculations. The effect of interferon on antibody formation was measured by determinations of hemagglutinating, hemolytic, and virus-neutralizing antibodies in the sera of treated and nontreated groups. The hemagglutinin and hemolysin titers after each successive inoculation were equal in both groups, indicating that interferon had no effect on their production. A decrease in the primary response to the viral antigen was associated with interferon induction; the booster response was unaffected. The possible use of interferon inducers as attenuants for immunization with live virulent viruses is discussed.


Gas chromatographic detection of in vivo activity of equine infectious anaemia virus.


Correlations between free radical production and viability of lyophilized bacteria. When Serratia marcescens cultures were treated with dilute solutions of phenol or hydrogen peroxide before drying or by lyophilization at suboptimal pH, the log of the number of cells surviving lyophilization was correlated with subsequent free radical production by the dried cells. Since the rate of free radical production and rate of death were similarly affected by temperature, the log of the number of cells surviving after 6 days was inversely related to the free radical concentration at that time. Free radicals were produced in proportion to the log of oxygen pressure, and viability was inversely related to oxygen tension; again, free radical concentration appeared to be correlated with the death of organisms.


Production of phosphatase by Aspergillus awamori var. kawachii in a low phosphate medium. The effect of phosphate on the production of phosphatases by Aspergillus awamori var. kawachii was studied. In a high phosphate medium, little phosphatase was produced, and the phosphatase activity was predominately for beta-glycerophosphate. In a low phosphate medium, the production of phosphatase was increased and activity for glucose-6-phosphate predominated. Medium containing 1 mg of phosphorus per 100 ml was optimal, and the amount of phosphatase produced in this medium was about 200 times that produced in a high phosphate medium. By means of column chromatography on diethylaminoethyl cellulose, the phosphatase produced in the high phosphate medium was found to be eluted mainly at fraction e; the phosphatase of the low phosphate medium was separated into fractions a, b, c, and d. Thus, the phosphatase fractions produced in the low phosphate medium were different from those of the high phosphate medium. Since no specific effect on the production of esterases was observed when various phosphate esters were used as substrates, the enzymes of phosphate metabolism appear to be activated by nonspecific phosphate sources.


Comparison of the capsular polysaccharides isolated from Klebsiella pneumoniae type 1, 2 and 3.


Hypophosphatasia: review and report of case.


Pharmacological actions of pseudoscopine and some of its derivatives.


The relation between quantum content and facilitation at the neuromuscular junction of the frog. 1. Experiments were done on the neuromuscular junction of the frog to study facilitation of the end-plate potential (e.p.p.) produced by one or more conditioning shocks applied to the motor nerve. Neuromuscular transmission was blocked with Mg (+)-tubocurarine chloride.2. In Mg-blocked preparations, facilitation increased with increasing Mg concentrations in the range 14-34 mM. The increase in facilitation was related specifically to the decrease in mean quantum content of the e.p.p., and was most marked with quantum contents less than 10.3. Facilitation in curarized preparations was similar in magnitude to that in preparations blocked with the lower Mg concentrations. Interaction between facilitation and depression in curarized preparations was consistent with the idea that facilitation was due to an increase in probability of transmitter release and depression to depletion of transmitter.


Familial multiple endocrine adenopathy (primary hyperparathyroidism and Zollinger-Ellison syndrome) in two siblings.


Pigmented villonodular synovitis of the wrist joint.


Solitary neural tuberculoid leprosy.

Solitary neural tuberculoid leprosy.


Angiofibroma in the frontal sinus of a dog.


Lipid alterations in beagles produced by atherogenic stress and vitamin A.


Isolation and properties of enterovirus receptors.


The role of cell membranes in the development of herpes virus.


Spontaneous intraperitoneal rupture of primary liver-cell carcinoma.


Geriatric clinics in local authority health centres.


Immunogenicity and specificity of collagen. V. Demonstration of three different antigenic determinants on calf collagen.


hypertrophic interstitial neuropathy and cataracts.


Neurosurgical complications affecting the oculomotor, trochlear, and abducent nerves.


Delayed neurological sequelae of electrical injuries.


Interagency planning for aftercare of mental patients in the community.


Radiocarbon: analysis of inorganic carbon of fossil bone and enamel. Carbon dioxide from calcium carbonate in fossil bone can be selectively separated from carbon dioxide in bone apatite by hydrolyzing the sample first in acetic acid and then in hydrochloric acid. Radiocarbon analyses of the inorganic carbon dioxide in three samples of known age clearly show calcium carbonate in fossil bone to be secondary and the carbonate of bone apatite to be indigenous and suitable for dating in some cases. Agreement between dates on collagen-bone apatite pairs increases the level of confidence.


Soluble and particle-bound hexokinase in normal and tumour tissues of rats.


Preparation and structure-activity relationship of reagents for cytochrome oxidase activity: potential for light and electron microscopy.


Lymphangiography.

Lymphangiography.


Trench mouth in children.

Trench mouth in children.


Cytomegalovirus inclusion disease (CID): the cytomegalovirus.


The influence of ACTH and adrenal cortex hormones on the reaction of the complement fixation test in the course of trichinellosis.


Angiotensin blood levels in hypovolemic shock during osmotic diuresis.


Comparative chromatography of the chloroplast pigments.


Suppression of inflammation and histidine decarboxylase by protein synthesis inhibitors.


Inhibition of cyclic 3',5'-nucleotide phosphodiesterase by phenothiazine and reserpine derivatives.


DNA methylated in vitro by a monofunctional alkylating agent as a substrate for a specific nuclease from Micrococcus lysodeikticus.


Cytochromes a and a3. Catalytic activity and spectral shifts in situ and in solution.


Enzymatic reduction of nitrate with flavin nucleotides reduced by a new chloroplast NADH-specific diaphorase.


Separation of microchonria, peroxisomes and lysosomes by zonal centrifugation in a Ficoll gradient.


A nitrite-reducing enzyme from Nitrosomonas europaea. Preliminary characterization with hydroxylamine ad electron donor.


Experimental gas gangrene with food-poisoning Clostridium perfringens type A.


Nephrotoxicity of anti-infective drugs.

Nephrotoxicity of anti-infective drugs.


Effect of alloxan diabetes and insulin administration on the incidence of pituitary necrosis caused by hexadimethrine bromide in rats.


Effect of Enovid on liver enzymes and accessory reproductive organs of male rat.


Studies in experimental tuberculosis: effect of reduced food consumption in infected guinea-pigs on carbohydrate metabolism.


Insulin-like activity in experimental tuberculosis and the effect of insulin administration on carbohydrate metabolism.


Studies on the phospholipids of mouse spleen on infection with Plasmodium berghei.


Blood cholesterol levels, autochthonous intestinal flora and Clostridium perfringens recovery in rhesus monkeys fed a high sucrose diet.


Effect of corticotropin on aldosterone excretion and plasma renin in normal subjects, in essential hypertension and in primary aldosteronism.


Effects of glucocorticoid administration on aldosterone excretion and plasma renin in normal subjects, in essential hypertension and in primary aldosteronism.


Thyroxine transport and turnover in major nonthyroidal illness.


Epinephrine synthesis in Cushing's syndrome.


Tissue culture assay of helper activity of murine leukemia virus for murine sarcoma virus.


Subcellular localization of tritium labeled vitamin D3 in rat intestinal mucosa.


Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease.


The biochemistry of supporting materials in organisms.


Oxidative phosphorylation in Escherichia coli.


The effect of 5-iodo-2'-deoxyuridine on herpes simplex virus infections in guinea-pig skin.


The interaction between phosphoryl transferase and submitochondrial particles.


Histochemical studies on deoxyribonuclease activity in normal and azo dye-fed rat livers by the modified phosphatase method.


Sensory traces versus the psychological moment in the temporal organization of form.


Activity of the cell-sap factor inhibiting DNA synthesis of rat ascites hepatoma cells in normal tissues, various malignant and minimal deviation hepatomas, as well as livers during the course of carcinogenesis.


Some characteristics in the pathway of RNA synthesis in hepatoma cells.


ACTH versus corticosteroids.

ACTH versus corticosteroids.


Presence of deoxycompounds in irradiated carbohydrates.


Cooperative study in the evaluation of therapy in multiple sclerosis; ACTH vs placebo in acute exacerbations. Preliminary report.


An hypothesis for the action of vitamin D on bone.


Properties of Aujeszky's disease virus strains isolated from swine pneumonia cases. Prelininary report.


Aspects of glycogen synthesis and degradation.


Phosphorescence from sulfur-containing bases in Escherichia coli t-RNA.


The diagnosis and management of the glycogen storage diseases.


Vesicular stomatitis virus RNA: complementarity between infected cell RNA and RNA's from infectious and autointerfering viral fractions.


An E. coli mutant with cryptic UDP-sugar hydrolase and altered metabolite regulation.


The mechanism of action of UDPG dehydrogenase.


II. The dissociation of the alcohol dehydrogenases.


Inhibition by citrate of pyruvate dehydrogenase in rat liver mitochondria.


The role of ubiquinone in the respiratory chain of Acetobacter xylinum. 1. Whole cells of Acetobacter xylinum were found to contain a quinone of the ubiquinone (coenzyme Q) group. The quinone was isolated from the cells and crystallized. It was identified by its physical, chemical and spectroscopic properties as a ubiquinone with 10 isoprene units (ubiquinone-10). No naphthaquinone was detected in the cells. 2. Cell-free extracts prepared by means of a French pressure cell were separated into three fractions by differential centrifugation. The ubiquinone was located predominantly in the particulate fraction sedimenting at 33000g, which also contained most of the NADH oxidase and malate oxidase activities. The concentration of ubiquinone-10 in extracts was similar to that of the flavoproteins and about three times the concentration of the individual cytochromes. 3. Aerobic incubations of crude extracts with either NADH or malate resulted in reduction of the endogenous ubiquinone-10 to steady-state concentrations of 55 and 40% of the total quinone respectively. In the presence of cyanide more than 95% of the endogenous ubiquinone-10 was reduced by either NADH or malate. 4. The initial rate of reduction of endogenous ubiquinone-10 by malate and the rate of ubiquinol oxidation, in A. xylinum extracts, were found to be compatible with the overall rate of malate oxidation with oxygen. 5. The effects of various respiratory inhibitors on the oxidation-reduction reactions of the endogenous quinone indicate that its position on the respiratory chain is between the malate flavoprotein dehydrogenase and the cytochrome chain.


A temperature-induced lesion in amino acid-transfer ribonucleic acid attachment in a psychrophile.


Incorporation of specifically labeled [14C] glucose into herpes simplex DNA.


Studies on ferrochelatase. The enzymic formation of haem in proplastids, chloroplasts and plant mitochondria. 1. Ferrochelatase was demonstrated in the chloroplasts and proplastids isolated from the primary leaves of beans (a dicotyledon) and oats (a monocotyledon). It was also detected in chloroplasts from etiolated bean seedlings made green by illumination before being harvested. The specific activities of the three types of bean organelles are similar, as are the specific activities of the oat proplastids and chloroplasts. 2. Chloroplasts from young spinach leaves also contain ferrochelatase; these chloroplasts were tested for their ability to form magnesium tetrapyrroles and found unable to catalyse the insertion of Mg(2+) into mesoporphyrin IX. 3. Ferrochelatase was also detected in potato tuber mitochondria. 4. Ferrochelatase activity in these plant preparations is much less stable on storage than similar preparations from bacteria and animal tissues. 5. Temperature affects the activities of spinach chloroplast ferrochelatase and rat liver ferrochelatase differently. Activity of the chloroplast enzyme increases as the temperature rises from 20.6 degrees to 26 degrees , but becomes increasingly inactivated as the temperature rises further to 38 degrees . The initial velocity of the mammalian enzyme, however, increases as the temperature rises from 25.8 degrees to 65 degrees , but the enzyme is inactivated after several minutes at 65 degrees .


Tumorigenicity of N-nitrosohexamethyleneimine.


Amino acid content and elemental composition of selected strains of Clostridium perfringens.


The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro.


Soluble RNA ethylase activity of normal and neoplastic mouse tissues.


Verrucae: virus structure, localization of antigens, and comparison with the Shope papilloma.


Myelin as a locus for radioantibody absorption in vivo in brain and brain tumors.


The study of normal and malignant cell antigens by mixed agglutination.


Action of a neutral lipid fraction on arterial blood pressure of adrenalectomized or hypophysectomized cats.


Avian leucocytic responses induced by stress and corticoid inhibitors.


Adenovirus infections in Delhi: isolation from tonsils and a serological survey.


Use of ultrasonic aerosols with ventilatory assistors.


Aldosterone hypersecretion in "non-salt-losing" congenital adrenal hyperplasia. Patients with the "non-salt-losing" form of the adrenogenital syndrome were studied before and after suppression of adrenal cortical activity with carbohydrate-active steroids. The response of aldosterone secretion to sodium deprivation was measured; in some patients response to adrenocorticotropic hormone (ACTH) was measured as well. The aldosterone secretion was normal and responded normally to sodium deprivation in all patients studied during suppression with carbohydrate-active steroids. This finding suggests that 21-hydroxylation of progesterone is normal in this syndrome. The sole abnormality in the production of aldosterone in these patients was found to be excessive secretion of aldosterone while they were not receiving suppressive doses of carbohydrate-active steroids. This finding strongly supports the view that the biogenetic pathways through which aldosterone is produced from progesterone are intact in this syndrome. No patient showed hypertension or hypokalemic alkalosis despite very high aldosterone secretion rates. This observation suggests that the hyper-aldosteronism is secondary to a tendency to sodium loss in the patient whose ACTH production is not suppressed. These studies provide additional evidence in support of the hypothesis that the salt-losing and "non-salt-losing" forms of adrenogenital syndrome are genetically and biochemically distinct.


A direct synaptic connexion between the left and right giant cells in Aplysia. 1. In Aplysia fasciata, intrasomatic stimulation of the giant cell (RGC) of the right upper quadrant of the abdominal ganglia is followed after a constant delay by the appearance of a synaptic potential recorded in the giant cell (LGC) of the left pleural ganglion.2. The synaptic potential recorded in the LGC soma has a biphasic form (hence biphasic post-synaptic potential or BPSP) consisting of a fast depolarizing phase of about 200-800 muV amplitude and 0.15-0.25 sec duration, followed by a slow hyperpolarizing phase of about 200-800 muV amplitude and 1-3 sec duration.3. During repetitive stimulation summation results in an over-all hyperpolarization at low frequencies (less than 5/sec) and an over-all depolarization for higher frequencies. Very high frequencies (25/sec) of stimulation of the RGC may elicit a spike in the LGC.4. Stimulation with two shocks showed increasing effects with shorter intervals on both the depolarizing and hyperpolarizing phase. These effects were progressive and there was no falling out of one of the two phases as might be expected if the BPSP was a composite of an inhibitory post-synaptic potential (IPSP) and an excitatory post-synaptic potential (EPSP).5. The effects of artificially imposed polarization of the LGC through a second micro-electrode suggest that the BPSP results from a chemical transmission mechanism for both its depolarizing and hyperpolarizing phases but electrical transmission cannot be excluded.6. Curare has no effect on the BPSP and thus excludes a cholinergic transmission mechanism. Chloride ions injected into the LGC soma do not appear to modify the BPSP and hence it is concluded that the hyperpolarizing phase is different from IPSPs of the same cell.7. No synaptic potential is recorded in the RGC following stimulation of the LGC, except in a single preparation in which the RGC soma was situated in the right pleural ganglion. In this case the synaptic potential recorded in both giant cells following stimulation of the other, was biphasic in form.8. It is concluded that the BPSP is a unitary monosynaptic potential which is a characteristic feature of the organization of these two giant cells.


Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism. The effect of dibutyryl cyclic adenosine 3',5'-monophosphate upon calcium and phosphate metabolism in thyroparathyroidectomized rats was undertaken in an effort to clarify the possible role of adenosine 3',5'-monophosphate (3',5' AMP) in parathyroid hormone action. The infusion of dibutyryl cyclic 3',5' AMP at a rate of 3 mg/hr into thyroparathyroidectomized rats leads to changes in calcium, phosphate, and hydroxyproline excretion, and calcium and phosphate concentrations in plasma that are qualitatively similar to those induced by parathyroid hormone given at a rate of 5 mug/hr. The effect of dibutyryl cyclic 3',5' AMP upon calcium and hydroxyproline mobilization from bone is blocked by thyrocalcitonin administration in the same way that thyrocalcitonin blocks PTH effects. Other closely related nucleotides do not act in the same way. These data indicate that dibutyryl cyclic 3',5' AMP produces effects similar to parathyroid hormone in thyroparathyroidectomized rats, and support the notion that 3',5' AMP is an intermediate in the mechanism of PTH action. However, the changes in magnesium and potassium excretion are different after dibutyryl cyclic 3',5' AMP infusion from those seen after PTH infusion. Also, theophylline was found to potentiate the action of smaller doses of dibutyryl 3',5' AMP, but not that of PTH.


An examination of the effects of osmotic pressure changes upon transmitter release from mammalian motor nerve terminals. 1. When the frequency of miniature end-plate potentials (m.e.p.p.s) was measured at neuromuscular junctions in rat diaphragm nerve preparations in vitro bathed in solutions having osmolarities between 200 and 700 m-osmoles/l. it was found that m.e.p.p. frequency was transiently increased by exposure to osmotic gradients exceeding 75 m-osmoles/l., and then declined, within 1 hr, to a steady level slightly higher than the control level of frequency. Smaller osmotic gradients caused a maintained increase in m.e.p.p. frequency. E.p.p. quantal content was initially increased and later profoundly decreased upon exposure of preparations to solutions with an osmotic pressure of 500 or 600 m-osmoles/l. but was unaffected by less hypertonic solutions.2. Variation of the Ca or Mg content of the bathing solutions did not alter these effects of osmotic pressure on the early transient increase in m.e.p.p. frequency or e.p.p. quantal content but affected the late steady increase in m.e.p.p. frequency.3. The value of the transient increase in m.e.p.p. frequency was exponentially related to the osmotic gradient in the range 0-300 m-osmoles/l. with a Q(10) of 1.95 (range 11-34 degrees C). Greater osmotic gradients did not further increase m.e.p.p. frequency. Variation of the ionic strength of the bathing medium did not influence osmotic effects upon frequency.4. The discrepancy between the effects of osmotic gradients upon spontaneous and nerve-impulse induced transmitter release was explained by an occlusion of the osmotic effects by depolarization of nerve terminals. Time-course studies showed that in the presence of 20 mM-KCl the m.e.p.p. frequency increase in response to an increase in osmotic pressure was small and was followed by a reduction in frequency to below control levels while osmotic pressure changes had no immediate effect upon m.e.p.p. frequency in solutions containing 30 mM-KCl.5. It was concluded that increased osmotic gradients could release transmitter by a mechanism independent of Ca and of nerve terminal depolarization.6. It is suggested that the initial transient effects of changes of osmotic gradient upon transmitter release are related to flow of water through the nerve terminal membrane, while the later effects are related to nerve terminal volume changes.


Greater specificity of 19S than 7S antibodies on haemagglutination-inhibition tests with closely related group B arboviruses.


Cytochrome oxidase activity during treatment of copper deficiency.


Management of colostomy, ileostomy, and ileal conduit.


Quantitative measurement of inhibition of aliesterases, acylamidase, and cholinesterase by EPN and Delnav.


Histochemical localization of alkaline ribonuclease and phosphodiesterase I in the central nervous system of the rat.


Evidence for a precursor in the biosynthesis of insulin.


The survival of the virus of infectious laryngotracheitis.


Induction of a high incidence of damage to the X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses, and carcinogens.


Primary carcinoma of the liver in infancy. Report of a case.


The use of an in vitro test of delayed type hypersensitivity for the detection of specific tumor antigen of transplantation type induced by SV 40 virus.


Transmission of atrial waves to the blood vessels of the digits and outer ear in cases of atrial flutter.


Effect of brief carotid sinus pressure on digital vascular tone.


Effect of rapid distension of large arteries and veins on the vascular tone of the fingers.


Hypermineralocorticoidism.

Hypermineralocorticoidism.


The metopirone test of pituitary corticotrophin release. Evaluation of 101 tests.


Incidence and clinical significance of tumor embolization to the lungs.


Prodromal trigeminal sensory neuropathy in progressive systemic sclerosis.


Plasma renin and angiotensinogen levels in pathological states associated with oedema.


Motor conduction in the deep palmar branch of the ulnar nerve.


Conformational transition in biological membrane studyed by the spin label method.


Selection of fructose 6-phosphate kinase mutants in Escherichia coli.


Activation of malate-linked reductions of NAD and flavoproteins in Ascaris muscle mitochondria by phosphate.


Identification of the major glycolipid from Mycoplasma sp., strain J as 3,4,6-triacyl-beta-Glucopyranose.


An NADH dependent cleavage of DTNB by the alpha-ketoglutarate dehydrogenase complex.


A charge-transfer intermediate in the mechanism of reduced diphosphopyridine nucleotide oxidation by ferric ions.


The reduction of ferric o-phenanthroline complexes by reduced diphosphopyridine nucleotide.


Transfer ribonucleic acids in Escherichia coli. Multiplicity and variation.


Lipid class and fatty acid composition of rat liver plasma membranes isolated by zonal centrifugation.


Phosphatidate phosphohydrolase activity in liver cell surface membranes.


Viral antibody levels and clinical status in acute exacerbations of chronic bronchitis: a controlled prospective study. A controlled prospective study was made of a group of patients with chronic bronchitis, in which serum antibodies against a group of viruses and Mycoplasma pneumoniae were estimated at regular intervals. Sixteen significant rises in antibody titre were shown, of which eight were associated with clinical acute exacerbations of bronchitis. In individual patients no correlation was found between the number of acute exacerbations or the aetiological agent and persistent change in ventilatory function as expressed by the F.E.V.(0.75).This study was compared with the results of a previous parallel investigation of the same patients done to study the significance of rhinovirus infections. In the present investigation 12% of the acute exacerbations were associated with the 11 agents tested compared with 14% associated with rhinoviruses in the earlier work.


Brain stem pathways modifying activity in the tuberal region of the hypothalamus.


Identity of nuclear NAD nucleosidase with a polyADP-ribose forming enzyme in Ehrlich ascites tumor cells.


Cancer of the breast with metastasis to the fallopian tube.


Elicitation of skin test reactions by complexes of penicillin or its derivatives with solubilized erythrocyte stroma receptors.


Influence of photoirradiation on the oxidation-reduction state of thioredoxin reductase.


Neurovascular syndromes related to the clavicle.


Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells.


Studies on the action of insulin in isolated adipose tissue cells. I. Stimulation of incorporation of 32P-labeled inorganic phosphate into mononucleotides in the absence of glucose.


Preoperative preparation and postoperative care of the colon.


Malic dehydrogenase. VII. The catalytic mechanism and possible role of identical protein subunits.


Adrenergic neurons in the cat superior cervical ganglion and cervical sympathetic nerve trunk. A histochemical study.


Physicochemical studies of the carcinoembryonic antigens of the human digestive system. A procedure has been described for the purification of the carcinoembryonic antigens (CEA) of the human digestive system. Tumor tissue extraction in 0.6 M perchloric acid followed by paper block electrophoresis and column chromatography on Sephadex G-200 resulted in highly purified CEA preparations as determined by both immunological and physicochemical criteria. The properties and composition of five different purified CEA preparations derived from digestive system cancer metastases were examined. The findings demonstrated a high degree of uniformity amongst these samples. Sedimentation coefficients ranged from 6.9 to 8S. Each sample showed the presence of 14 different amino acid residues and six different carbohydrate constituents (four of which could be quantitated with the amount of material available for analyis). Studies of a purified CEA preparation from a primary hepatoma yielded results which, in some respects, differed from those obtained with the CEA samples of metastatic tumor origin. The implications of these variations were discussed with regard to the probable presence of non-CEA components in the hepatoma preparation. Of primary importance was the observation that the few normal adult digestive system tissues tested failed to show the presence of constituents similar to the CEA. This finding would seem to indicate that, in the adult, the carcinoembryonic antigens of the human digestive system are qualitatively tumor-specific and are not dectectable in comparable normal tissues.


Peptide hormones in plasma.

Peptide hormones in plasma.


Effect of inhalation anesthetics on monosynaptic and plysynpatic transmission in the spinal cord.


Studies on the cortical control of the adrenal medulla in the rat.


The evolution of primary aldosteronism: 1954-1967.


Antagonism of experimental cyanide toxicity in relation to the in vivo acitivity of cytochrome oxidase.


Detection of biologically defective molecules in component I of polyoma virus DNA.


Transfer of Rous virus genome from rat tumour cells to chick cells at high temperature.


Thrombin-induced platelet release reaction and platelet lysosomes.


Congenital cytomegalic inclusion disease with porencephaly.


Corticofugal control of the presynaptic inhibition in the spinal trigeminal nucleus of the cat. The effect of pyramidotomy and barbiturates.


Replication of polyoma virus DNA. I. A resting cell system for biochemical studies on polyoma virus.


A discssion of control of brain serotonin and norepinephrine by specific neural systems.


The metabolism of the alkylphosphate antagonists and its pharmacologic implications.


Syndactylism, dyschromia, and the arsenical dilemma.


Antiviral agent from lambda-infected Escherichia coli K-12. I. Isolation. Phagicin, which is an antiviral agent active against deoxyribonucleic acid (DNA) viruses such as vaccinia and herpes simplex, has been identified as a phage internal protein. It was found in infected Escherichia coli lysates, but could also be obtained by disruption of the purified infective particles after incubation with LiCl at 46 C for 15 min or by sonic treatment. After centrifugation at high speed, the antiviral activity was found in the DNA phase and could be separated by chromatography on Sephadex gels with 0.2 M phosphate buffer (pH 7.5) as the eluent. Phagicin present in lysates after removal of infective particles was nondialyzable and was bound to nucleic acids. It could be released during precipitation of nucleic acids by streptomycin sulfate, and in this form it could be easily dialyzed. The antiviral activity of phagicin was specific for herpes simplex and vaccinia viruses.


Eccrine poroma.

Eccrine poroma.


Treatment problems leading to readmissions of schizophrenic patients.


[Induced fluorenscence in the study of tissue culture cells infected with viruses. 3. Nnucleic acids in tissue culture cells infected with Picorna viruses].


Interaction of polypeptide hormones with lipid monolayers. 1. The interaction between lipid monolayers spread on the surface of water and oxytocin, [8-arginine]-vasotocin and [1-asparagine-5-valine]-angiotensin II in the subphase was investigated in a Langmuir surface trough by studying the changes in pressure produced on injection of various quantities of the polypeptide solution under the film. 2. The effect of 2m- and 4m-urea on the character of the adsorption is reported. 3. Structures for the adsorbed films formed in this way are suggested. 4. If the lipid monolayer is taken as a suitable model of cell membranes, then it may be supposed that the effect of such structures forming in cell membranes would be to provide effective ;pores' to facilitate the movement of water and other small molecules across the membrane.


A comparison of the effects of NN'-dicyclohexylcarbodi-imide, oligomycin A and aurovertin on enrgy-linked reactions in mitochondria and submitochondrial particles. 1. The effects of dicyclohexylcarbodi-imide, oligomycin A and aurovertin on enzyme systems related to respiratory-chain phosphorylation were compared. Dicyclohexylcarbodi-imide and oligomycin A have very similar functional effects, giving 50% inhibition of ATP-utilizing and ATP-generating systems at concentrations below 0.8nmole/mg. of submitochondrial-particle protein. Aurovertin is a more potent inhibitor of ATP synthesis, giving 50% inhibition at 0.2nmole/mg. of protein. However, aurovertin is a less potent inhibitor of ATP-utilizing systems: the ATP-driven energy-linked nicotinamide nucleotide transhydrogenase is 50% inhibited at 3.0nmoles/mg. of protein and the ATP-driven reduction of NAD(+) by succinate is 50% inhibited at 0.95nmole/mg. of protein. 2. With EDTA-particles (prepared by subjecting mitochondria to ultrasonic radiation at pH9 in the presence of 2mm-EDTA) the maximum stimulation of the ATP-driven partial reactions is effected by similar concentrations of oligomycin A and dicylcohexylcarbodi-imide, but the latter is less effective. The stimulatory effects of suboptimum concentrations of dicyclohexylcarbodi-imide and oligomycin A are additive. Aurovertin does not stimulate these reactions or interfere with the stimulation by the other inhibitors. 3. Dicyclohexylcarbodi-imide and oligomycin A stimulate the aerobic energy-linked nicotinamide nucleotide transhydrogenase of EDTA-particles, but the optimum concentration is higher than that required for the ATP-driven partial reactions. Aurovertin has no effect on this reaction. 4. The site of action of dicyclohexylcarbodi-imide is in CF(0), the mitochondrial fraction that confers oligomycin sensitivity on F(1) mitochondrial adenosine triphosphatase.


The redox state of the nicotinamide-adenine dinucleotides in rat liver homogenates. 1. The redox state of the NAD couple of rat liver mitochondria, as measured by the [beta-hydroxybutyrate]/[acetoacetate] ratio, rapidly changed in the direction of oxidation during the preparation of homogenates in a saline medium. The value of the [beta-hydroxybutyrate]/[acetoacetate] ratio fell from 2.3 to 0.15 in 10min. EDTA diminished the fall and succinate prevented it. 2. The redox state of the rat liver cytoplasm, as measured by the [lactate]/[pyruvate] ratio, changed slightly in the direction of reduction during the preparation of homogenate. This was prevented by succinate. 3. In unsupplemented homogenates the differences in the redox states of mitochondria and cytoplasm decreased. Succinate and EDTA together maintained the differences within the physiological range. A measure of the ability of the mitochondria to maintain different redox states in mitochondria and cytoplasm is the value of the expression [lactate][acetoacetate]/[pyruvate][beta-hydroxybutyrate]. If there are no differences in the redox states of the NAD in the two cell compartments the value of the expression is 444 at 37 degrees . The value in the intact rat liver is between 4.7 and 21. 4. alpha-Oxoglutarate or glutamate were still more effective than succinate in maintaining high [beta-hydroxybutyrate]/[acetoacetate] ratios in the homogenates because these substrates supply a reducing agent of NAD(+) and, through succinate, an inhibitor of the oxidation of NADH. 5. When supplemented with alpha-oxoglutarate and EDTA, homogenates readily adjust the redox state of the beta-hydroxybutyrate dehydrogenase system after it has been upset by the addition of either acetoacetate or beta-hydroxybutyrate. 6. Amytal and rotenone raised the value of the [beta-hydroxybutyrate]/[acetoacetate] ratio. This is taken to indicate that the reduction of acetoacetate in the homogenates was not an energy-linked process. 7. 2,4-Dinitrophenol shifted the [beta-hydroxybutyrate]/[acetoacetate] ratio in the presence of succinate in favour of oxidation because it inhibited the oxidation of succinate and accelerated the oxidation of NADH. 8. Rotenone increased the rate of ketone-body formation of liver homogenates, though it decreased the rate of oxygen uptake.


Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol. 1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD(+) was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9.4 for the oxidation of the cis-diol and 9.8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.


A rapid simple method for the assay of renin in rabbit plasma. 1. EDTA (10mm), 2,3-dimercaptopropan-1-ol (10mm) and chlorhexidine gluconate (0.005%, w/v) cause complete inactivation of plasma enzymes that degrade angiotensin I, but have no effect on the reaction of renin with its substrate. The reagents were termed the selective inhibitors. 2. Thus it is possible to measure renin in plasma by its ability to catalyse the release of angiotensin I. 3. Sterile plasma, treated with the selective inhibitors, is incubated with renin substrate (500-1000ng. of angiotensin content/ml.) at pH6 at 42 degrees for 6hr. 4. Under these conditions the reaction obeys first-order kinetics. Renin activity is calculated in terms of the percentage release of the angiotensin content/hr. 5. As described, the assay is sufficiently sensitive to measure renin in the plasma of all normal rabbits. By extending the length of the incubation, much lower activities can be measured.


Properties of renin substrate in rabbit plasma with a note on its assay. 1. Rabbit plasma enzymes that degrade angiotensin I are inhibited completely by the combination of 2,3-dimercaptopropan-1-ol (10mm), EDTA (10mm) and chlorhexidine gluconate (0.005%, w/v). These compounds do not modify the reaction of renin with renin substrate and are termed the selective inhibitors. 2. The renin substrate concentration of plasma can be measured as angiotensin I content by incubating plasma plus the selective inhibitors with renin for a time sufficient to allow complete utilization of renin substrate. 3. This reaction obeys first-order kinetics to substrate concentrations of at least 1000ng. of angiotensin I content/ml. In general, the renin substrate concentrations of normal rabbit plasmas are less than 1000ng. of angiotensin I content/ml. Thus the time required for the complete release of angiotensin I from normal plasma is inversely related to renin activity and is independent of renin substrate concentration. 4. A method for the assay of renin substrate, taking these reaction kinetics into account, is presented.


The mechanism of disulphide reduction by mitochondria. 1. Cystamine was reduced to the corresponding thiol by rat liver mitochondria, even in the presence of rotenone or antimycin A. 2. The reduction of disulphides was stimulated by the accumulation of NADH or by the addition of NADH to osmotically ;shocked' mitochondria. 3. Energy made available by oxidative phosphorylation was not essential for the reduction of disulphides. 4. Cystamine was not reduced during the oxidation of NADH by ultrasonically treated particles, which had lost their capacity for oxidation of alpha-oxo acids. 5. In intact mitochondria, arsenite and other inhibitors of vicinal dithiols caused a decrease in the capacity for reduction of disulphides concomitantly with an inhibition of the oxidation of alpha-oxo acids. 6. Isolated lipoamide dehydrogenase reduced cystamine at the expense of NADH, provided that lipoic acid was also present. 7. It is concluded that in mitochondria the reduction of cystamine and related disulphides is probably brought about by interaction with reduced lipoic acid, generated by the alpha-oxo acid dehydrogenase complexes during the oxidation of alpha-oxo acids or by reaction of lipoamide dehydrogenase with NADH.


Inhibition of protein synthesis by an RNA fraction from myeloblastosis virus.


Orf.

Orf.


A new ultrasensitive method for the determination of proteolytic activity.


Light absorption of flavosemiquinone metal chelates.


Decline and restoration of glycolysis in homogenates from ischemic livers.


Adenovirus myocarditis in mice. An electron microscopic study.


Induced hypersensitivity to combinations of serotonin and histamine in a strain of mice ordinarily highly resistant to histamine sensitization.


Indirect inguinal hernia in congenital rubella.


Normal growth with subnormal growth-hormone levels.


Fluorescent-antibody test for cytomegalovirus macroglobulin.


Hypoglycemia and the central nervous system.


Acute and subacute neuropathies.

Acute and subacute neuropathies.


Lysosomes and the responses of cells to toxic materials.


The release and assay of hormones in the circulation.


Choline acetyltransferase: regional distribution in the abdominal ganglion of Aplysia. Using a new microassay, we have determined the properties and the regional distribution of choline acetyltransferase in the abdominal ganglion of Aplysia. Enzyme concentrations in homogenates of groups of cells and in single identified cells indicate that neurons which function as neurosecretory cells, and which do not form chemical synapses with other cells or with peripheral structures, have little or no ability to synthesize acetylcholine; neurons which are involved in visceromotor integrations, and which connect with each other or with the periphery, have a substantial concentration of the enzyme.


Induction of sorbitol dehydrogenase by sorbitol in Aspergillus niger.


The adrenal cortex. I. Historical aspects. II. Clinical considerations.


Diminished effect of sympathetic nerve stimulation in cats pretreated with 5-hydroxydopa; formation and liberation of false adrenergic transmitters.


The 7H11 medium for the cultivation of mycobacteria.


Vasopressin in the evaluation of pituitary-adrenal function.


The circulating lymphocyte--its role in infectious mononucleosis.


Immunohistochemical identification of actomyosin in myoepithelium of human tissues.


Acute tibial pain.

Acute tibial pain.


Hepatoma following carbon tetrachloride poisoning.


The effects of vitamin D2 and dietary phosphorus on oxidative enzymes in the epiphyseal cartilage of rachitic rats. A histochemical study.


Morphologic and biochemical studies of dog heart mitochondria after short periods of ischemia.


Histochemical study of effects of hypoxia and isoproterenol on rat myocardium.


Cholangiocarcinoma causing hypercalcemia and hypophosphatemia without skeletal metastases (pseudohyperparathyroidism).


Studies of enzyme activities in uterine and ovarian tumours. 3. A comparison of enzyme activity in patient's serum with the enzyme activity of the fluids in different cystic ovarian tumours.


Pathological findings after long-term sulfonylurea therapy.


Heterogeneity in the ability of rabbit 7S and 19S neutralizing antibodies to differentiate between intratypic antigenic variants of Herpes simplex virus.


Electron microscopic observations of the interaction of macrophages and lymphocytes in a virus-induced murine lymphoma.


Primary carcinoma of the liver in east Pakistan.


Further investigation of histochemistry of fructose-1,6-diphosphate D-glyceraldehyde-3-phosphate-lyase in the rat brain.


Treatment and prevention of rheumatic fever and rheumatic heart disease.


Isolation of a bovine rhinovirus.

Isolation of a bovine rhinovirus.


Infections in recipients of liver homografts.


Studies on hepatic glycolytic enzymes of normal and scorbutic guinea pigs administered acetoacetate.


Mechanism of diazoxide hyperglycemia in animals.


The effects of diazoxide and benzothiadiazine diuretics upon phosphodiesterase.


Biochemical aspects of the hyperglycemic action of diazoxide.


Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.


Inhibition of insulin release by diazoxide and its relation to catecholamine effects in man.


Studies on diazoxide-induced hyperglycemia: an extrapancreatic mechanism.


Clinical use of diazoxide and studies of the mechanism of its hyperglycemic effects in man.


Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus, and patients with organic hypoglycemia.


The therapeutic application of diazoxide in pediatric hypoglycemic states.


Clinical experience with diazoxide.

Clinical experience with diazoxide.


Control of hypoglycemia with diazoxide and hormones.


Clinical and physiologic studies using diazoxide in the treatment of hypoglycemia.


Lipid chemistry and metabolism.

Lipid chemistry and metabolism.


Isolation of cytomegalovirus from the blood leucocytes of a patient with post-transfusion mononucleosis.


Transmission in sympathetic ganglia.

Transmission in sympathetic ganglia.


Antibodies to reoviruses, parainfluenza 3 virus, encephalomyocarditis virus and infectious bovine rhinotracheitis virus in porcine serums.


Clinical, physiological and pathological observations in a case of progressive autonomic nervous system degeneration associated with Holmes-Adie syndrome and peripheral neuropathy.


Oxidation-reduction properties of the mitochondrial flavoprotein chain.


Enzyme localization in the inner and outer membranes of rat liver mitochondria.


Meningioma of the optic nerve.

Meningioma of the optic nerve.


The hypophyseal-adrenocortical response to various different stressing procedures in ACTH-treated rats.


The influence of norethindrone and mestranol on pituitary-adrenal function.


Effects of substrates and hormones on glycogen content of the mouse hemidiaphragm in vitro.


On the viral etiology of epidermodysplasia verruciformis Lewandowsky-Lutz. Electron microscope studies.


Chromosome breakage induced by a carcinogenic hydrocarbon in Chinese hamster cells and human leukocytes in vitro.


Aortography in children with abdominal masses.


Oral polio immunization of the newborn infant; a possible method for overcoming interference by ingested antibodies.


Changes in structure of human bone with age.


Isolation of a receptor complex for a tumor specific agglutinin from the neoplastic cell surface.


Antiviral properties of 1-phenoxymethyl-3,4-dihydro and 1,2,3,4-tetrahydroisoquinolines.


Radiation enhancement of SV40 transformation in 3T3 and human cells.


Evidence of infection with influenza viruses in migratory waterfowl.


Spin-labeled hemoglobin derivatives in solution and in single crystals.


Specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses.


Hydrogen-addition radicals formed in the aromatic rings of amino acids, polyamino acids, and proteins.


Prompt stimulation of the organic binding of iodine in the thyroid by adenosine 3',5'-phosphate in vivo.


Localization of nucleotide phosphohydrolase activity within vaccinia.


A method for determining the fraction of the viral genome transcribed during infection and its application to adenovirus-infected cells.


In vitro assembly of poliovirus-related particles.


Automated procedure for serum aldolase estimation. Fructose-1, 6-diphosphatase and fructose-1-phosphatase.


A comparison of reduced-NAD preparations from four commercial sources.


Optimum reaction conditions for human lactate dehydrogenase isoenzymes as they affect total lactate dehydrogenase activity.


Endolymphatic infusion of I-131 in the treatment of malignant melanoma: early experiences.


Treatment of alcoholism.

Treatment of alcoholism.


Peripheral neuropathy associated with disulfiram (Antabuse) therapy.


Bluetongue disease in cattle.

Bluetongue disease in cattle.


Abortion in a dairy herd vaccinated for infectious bovine rhinotracheitis.


The quantitative thin layer chromatography of corticosteroids.


Effect of intake of copper, molybdenum and sulphate on copper metabolism in sheep. II. Copper status of the newborn lamb.


Induction of nephroblastomas in the rat with dimethylnitrosamine.


On the effects of blastomogenic substances on the organism during embryogenesis.


Bactericidal activity of mouse lung in reovirus infection.


Pathogenesis of monkey pox.

Pathogenesis of monkey pox.


Factors modifying host resistance to viral infection. I. Effect of immunosuppressive drugs on experimental infection of mice with encephalomyocarditis virus.


Effect of 6,9-diamino-2-ethoxyacridine on bacteriophages and animal viruses.


Inhibition of replication of herpes simplex and vaccinia viruses in vitro by Escherichia coli and lipopolysaccharide.


Steroid determinations in six cases of hyperplasia and three cases of tumour of the adrenal cortex.


Phosphoinositides of Corynebacterium xerosis.


Latency time, maximal amplitude and electromyography in diabetic patients.


Comparative studies on the histological picture of lesions in chick chorio-allantoic membranes infected with vaccinia, smallpox and alastrim viruses.


Chromosome analysis of Rous tumours in the rabbit.


Continuous determination of the clearance of 131-I-diatrizoate, an inulin substitute.


Mechanism of enhancement of eccrine sweating by localized heating.


Bordetella pertussis-induced alteration of the normal hyperglycemic response of mice to 3',5'-adenosine phosphate. Blockade of the adrenergic receptors or the injection of Bordetella pertussis vaccine prevented the normal hyperglycemic response of CFW mice to exogenous cyclic 3',5'-adenosine phosphate (3',5'-AMP). The cyclic nucleotide was also ineffective in offsetting the histamine hypersensitivity of the beta-adrenergically blocked and the pertussis-sensitized groups. These observations suggest that the autonomic malfunction occurs at a point(s) subsequent to release of 3',5'-AMP. Neither the hyperglycemic effect of epinephrine or 3',5'-AMP, or both, nor the histamine sensitivity of pertussis-pretreated animals was influenced by the subcutaneous administration of theophylline.


Isoelectric analysis of cytolytic bacterial proteins.


Action mechanism of phenothiazine derivatives on mitochondrial respiration.


Fine structure of laminaran of Eisenia bicyclis.


Oxidative phosphorylation in Micrococcus denitrificans. V. Effects of iron deficiency on respiratory components and oxidative phosphorylation.


Oxidative phosphorylation in Micrococcus denitrificans. IV. Further characterization of electron-transfer pathway and phosphorylation activity in NADH oxidation.


Studies on erythrocyte glycolysis. VII. Changes of glycolytic intermediates in erythrocytes during storage in acid-citrate-dextrose medium.


Nasolabial cysts: report of two cases.

Nasolabial cysts: report of two cases.


The primary structure of valine-I transfer ribonucleic acid from Torulopsis utilis.


Sebaceous gland adenoma of the buccal mucosa: report of case.


Auriculotemporal syndrome after injection into the temporomandibular joint: report of case.


A method for the propagation of large amounts of Rous sarcoma virus.


Focus formation by murine sarcoma virus: enhancement by DEAE-dextran.


Structure of simian virus 40. IV. The polypeptide chains of the virus particle.


Evidence for differences in size and composition of the poliovirus-specific polypeptides in infected HeLa cells.


Proteins of Rous sarcoma virus.

Proteins of Rous sarcoma virus.


Metabolism and mechanism of action of estrogens. IX. Metabolism of estrone by microsomes from rat liver and transplanted hepatocellular carcinomas including minimal deviation (Morris 5123 C, 7800, 9121) hepatomas.


Action of angiotensin in normal, adrenalectomized, and renal hypertensive trained dogs.


A myxovirus isolated from a case of infectious hepatitis.


Hydrolitic enzymes in cells of the prostate gland and seminal vesicles of castrated white rats.


Fine structural changes in rat liver cells in response to prolonged thioacetamide.


Renin and angiotensin in health and disease.


The influence of reserpine on the inhibition of ACTH-secretion induced by exogenous ACTH or a corticoid injection.


Combination of potassium perchlorate and propylthiouracil in the treatment of thyrotoxicosis.


A correlative study of endocrine rhythms in rats.


Isolation of inorganic pyrophosphate from bovine and human teeth.


Hypothalamic-pituitary-adrenal function in the elderly.


The determinants of left ventricular isovolumetric contraction time.


Herpes simplex virus infection of the cornea.


A case of foetal vaccinia.

A case of foetal vaccinia.


Breast cancer after exposure to the atomic bombings of Hiroshima and Nagasaki.


Effects of vagal stimulation on S-A and A-V nodes.


A renin-inactivating system in rat plasma.