Thin-layer and column chromatography of erythromycins and some degradation products.


A rapid preparative thin-layer chromatographic technique for serum lipids.


Characterization of vitamin K from bovine liver. Concentrated fractions of vitamin K from bovine liver were purified by thin-layer chromatography and fractions were analyzed by UV spectroscopy and mass spectrometry. The chromatographic behavior of the purified vitamins was compared with that of known compounds on thin layers of silica gel, either untreated or impregnated with silver nitrate or paraffin. The principal forms of vitamin K recovered from bovine liver were highly lipophilic. Two fractions were obtained which collectively gave identifiable mass spectra of menaquinone-10, menaquinone-11, and menaquinone-12.


Biosynthesis of beta-glucuronides of retinol and of retinoic acid in vivo and in vitro. After the intraportal injection of retinol-6,7-(14)C to rats, the O-ether derivative of retinol, retinyl -glucosiduronate, appears in the bile. Both retinoyl -glucuronide and retinyl -glucosiduronate are also synthesized in vitro when washed rat liver microsomes are incubated with uridine diphosphoglucuronic acid (UDPGA) and either retinoic acid or retinol, respectively. The synthesis of retinoyl -glucuronide was also demonstrated in microsomes of the kidney and in particulate fractions of the intestinal mucosa. The glucuronides were characterized by their UV absorption spectra, by their quenching of UV light or fluorescence under it, by their thin-layer chromatographic behavior in two solvent systems, and by the identification of products released during their hydrolysis by -glucuronidase. With retinoic acid as the substrate, the UDP glucuronyl transferase of rat liver microsomes had a pH optimum of 7.0, a temperature optimum of 38 degrees C, and a marked dependence on the concentrations of both retinoic acid and UDPGA, but was unaffected by a number of possible inhibitors, protective agents, and competitive substrates. The conversion of retinal to retinoic acid and the synthesis of retinoyl -glucuronide from retinoic acid could not be detected in whole homogenates, cell fractions, or outer segments of the bovine retina.


Mass spectrometry of derivatives of cyclopropene fatty acids. Diketo fatty acids prepared by ozonization of cyclopropene fatty acids have been separated and purified by chromatographic techniques. Mass spectra of esters of these compounds and of methanethiol adducts of cyclopropene acid esters are reported and interpreted. Location of the ring from examination of mass spectra of these derivatives appears to be a straightforward matter.


Analysis of fatty acids of human red cells without lipid extraction. Exposure of human red cells to 2 N HCl for 18-20 hr at 110 degrees C appears to release the total fatty acid, which can then be esterified for GLC analysis. This technique is simpler and may be more reliable than the conventional methods that depend on lipid extraction of the red cells.


Crisis: paradigms of intervention.

Crisis: paradigms of intervention.


MNA economic security program; past, present and future.


Cerebral tumors in infancy. 66 clinicoanatomical case studies.


The therapeutic milieu of the art department at the Allan Memorial Institute.


Multiple hemangiomata with thrombopenia. An unusual case with comments on steroid therapy.


Panel discussion on ulcerative colitis.

Panel discussion on ulcerative colitis.


David HP: Auxiliary personnel in nursing--World Health Organization.


Clinicopathological conference.

Clinicopathological conference.


Repair of ptosis using human sclera.

Repair of ptosis using human sclera.


Remotivation for return to community life.


Speaking out. On: is nursing tuned-in to the turned-on generation?


Some criteria of clinical change and measurement.


Nursing care plans: survey of status and opinions about current usage.


Inflammatory changes in newly formed vessels of carrageenin-induced granulomas after systemic 5-hydroxytryptamine, bradykinin, kallikrein, or lysolecithin.


The metabolism of isolated pneumocytes from rabbit lung.


Psychiatric drugs & trends. Look-alike and sound-alike drugs.


Isolation of cytomegalovirus and clinical manifestations of infection at different ages.


Some properties of cytoplasmic RNA fractions of the mouse Ehrlich ascites carcinoma.


Early and late after discharges of amphibian sympathetic ganglion cells.


In vivo dialysis of faeces as a method of stool analysis. 3. The effect of intestinal antibiotics.


Effects of angiotensin and norepinephrine infusions on total plasma volume and extracellular fluid space in man.


Hypothalmic-pituitary-adrenal function in thyrd disorders: effects of methopyrapone infusion on plasma corticosteroids.


The antigenic use of periodate-treated adrenocorticotropic hormone (ACTH).


Conformational changes of acetylcholinesterase.


Community mental health in the Netherlands. The story of Dr. Arie Querido.


Inhibition of yeast alcohol dehydrogenase by N1-benzylpyridinium chlorides.


Pulmonary and mediastinal lymphography.

Pulmonary and mediastinal lymphography.


Total myelography with radiopaque emulsions.


Psychiatric drugs and trends. The weapon--education...the target--drug abuse.


Several early angiographic findings in brain abscess including "the ripple sign".


The diagnosis of intracranial cysts by means of the brain scan.


Angiography of Wilms's tumor.

Angiography of Wilms's tumor.


The nurse therapist.

The nurse therapist.


Speaking out. On: principle and responsiblity.


A quantitative electron microscopic study of the virus particles found in cells infected with Rous sarcoma virus.


Immunochemical studies of foot-and-mouth disease. II. Characterization of RNA-free viruslike particles.


Rescue fantasy in the nurse therapist relationship with a psychotic child.


Amino acid composition and C-terminal sequence of foot-and-mouth disease virus protein.


Teaching behavioral observation to psychiatric nursing students.


Development of S and T antigens and oncogenicity in hamster embryonic cell lines exposed to SV40.


Reversible inhibition of induction of mengovirus RNA polymerase and of virus maturation in Novikoff rat hepatoma cells by phenethyl alcohol.


Studies on the mechanism of enhancement of adenovirus 7 infection in African green monkey cells by simian virus 40: formation of adenovirus-specific RNA.


Internuclear transfer of SV40-T-antigen in absence of infectious virus.


Surface layer in tumor cells transformed by adeno-12 and SV40 viruses.


Paromomycin in the treatment of intestinal amebiasis; a short course of therapy.


Plasma "cortisol" response to Synacthen in patients on long-term small-dose prednisone therapy.


Hypothalamo-pituitary-adrenal function in patients on long-term adrenocorticotrophin therapy.


Electron microscope observation of herpes-like particles in the iris.


Ultrastructure of tumor cells during mitosis.


Ultracytochemical studies on aberrant structures in avian virus tumor cells.


Rectal and colonic mucosal biopsy findings and faeces, sigmoidoscopy, and histopathological correlation in amoebiasis and other colitis.


The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Identification of D-glyceric acid and 3-O-methyl-D-glucose in the polysaccharide.


Mercury(II) stimulation of malate dehydrogenase activity.


Serial hormone assays in a patient with secondary amenorrhoea treated with clomiphene and gonadotrophins.


Synthesis of a protected C-terminal delta-aminovaleric acid analog of the peptide sequence occurring at positions 11-19 in adrenocorticotropins.


Cowper's gland carcinoma. Report of a case.


A collagenaselike substance  produced by eggs of Schistosoma mansoni.


Problems of correct interpretation of radioisotope renograms: experimental observations and clinical experiences.


Insulin-secreting tumors of the pancreas.


Primary tumors and cysts of the mediastinum.


Inhibitory effect of 1,2-bis(2-benzimidazolyl)-1,2-ethanediol derivatives on poliovirus.


High titre T antigen with minimal amounts of structural antigen in adenovirus-infected cells treated with hydroxyurea.


Polyoma virus-induced release of inhibition of cellular DNA synthesis caused by iododeoxyuridine.


Holographic model of temporal recall.

Holographic model of temporal recall.


Effect of cocaine, desipramine and angiotensin on uptake of noradrenaline in tissues of pithed rats.


Electron spin resonance study of nitroxide radicals from diethylhydroxylamine, dioctylhydroxylamine and n-hydroxypyrrolidine.


Failure to induce transplantation resistance against polyoma tumour cells with syngeneic embryonic tissues.


Effect on the guinea-pig taenia coli of the substitution of strontium or  barium ions for calcium ions.


External chemical messengers. IV. Pineal gland.


Gas chromatography for detection of viral infections. Gas chromatograms of sertim extracts of dogs inoculated with canine infectious hepatitis virus showed two metabolites not observed in uninoculated animals. Chromatograms of extracts of tissue cultures of dog kidney, inoculated with viruses causing canine hepatitis, herpes, and distemper, and a parainfluenza virus similar to simian virus-5, each showed two or more different metabolites. Two of the distinguishing products from cultures inoculated with hepatitis virus were chromatographically indistinguishable from those found in serums of the animals.


Dimethyl sulfoxide: an inhibitor of liver alcohol dehydrogenase. Dimethyl sulfoxide inhibits horse liver alcohol dehydrogenase. In the direction of aldehyde reduction, this inhibition is competitive with aldehyde, with an inhibition constant of 5 x 10(-3)M. Dimethyl sulfoxide reacts with the binary complex consisting of enzyme and the reduced form of nicotinamide -adenine dinucleotide to form a highly fluorescent ternary complex, with a dissociation constant similar to the inhibition constant. The inhibition of aldehyde reduction can be interpreted as due to competition between aldehyde and dimethyl sulfoxide for the carbonyl binding site of the above-mentioned binary complex.


The presence of human enteric viruses in sewage and their removal by conventional sewage treatment methods.


Effect of angiotensin and norepinephrine upon urate clearance in man.


Eosinophilic spongiosis in pemphigus. A report of an unusual hitological change in pemphigus.


Aerobic glycolysis, oxygen uptake, and enzyme activity of the electron transport system in neoplastic and non-neoplastic ovarian tissue grafted into the spleen of C57BL mice.


Pseudomonas aeruginosa in dermatology.

Pseudomonas aeruginosa in dermatology.


The influence of whole-body exposure to x-rays or neutrons on the life span distribution of tumors among male rats.


Ribonuclease activity of ribonucleoprotein particles isolated from livers of rats fed 4-dimethylaminoazobenzene, primary liver tumors, and Novikoff hepatoma.


Base compositions of RNA of nuclear fractions obtained by sequential extraction with saline solutions.


Hormonal control of ascorbic acid transport in rat adrenal glands.


Site of action of trophic hormones upon the biosynthetic pathways to steroid hormones.


Effects of androgens on incorporation of labeled amino acids into proteins by prostate mitochondria.


Species differences in inducibility of phenylethanolamine-N-methyl transferase.


Inhibition of adrenal progesterone biosynthesis by 3',5'-cyclic AMP.


Homotransplantation of articular cartilage and isolated chondrocytes. An experimental study in rabbits.


Phospholipids in the nervous system of molluscs.


Localization of gamma-aminobutyric-alpha-oxoglutaric acid transaminase in mouse brain.


Effect of certain drugs on perfused human placenta. 8. Angiotensin-II antagonists.


Intracranial aneurysm with panhypopituitarism with associated aneurysms of thoracic and abdominal aortas.


Sero-epidemiological study of cytomegalovirus infections in Melbourne children and some adults.


Isolation of human cytomegalovirus from the circulating leucocytes of a leukaemic patient.


Herpesvirus infection of human mesodermal tissue (cornea) detected by electron microscopy.


Peptide inhibitors of the renin-angiotensin system.


Stimulus-induced release of substances from olfactory bulb using the push-pull cannula.


Functioning  islet cell adenoma in the newborn. Report of a case with failure of diazoxide.


Quantitative gas chromatography of adrenal cortical steroids.


Identification of estra-1,3,5(10),16-tetraen-3-ol (estratetraenol) from the urine of pregnant women (1).


Reduced quinolines and quinolinium compounds. I. Reduction of quinoline analogs of model compounds for coenzyme I.


Determination of blood corticoids using the in vitro resin uptake of 3H-prednisolone.


Studies on the hydrolysis of gel-filtered urinary oestrogens.


The lipid-mobilizing effect of some pituitary gland perparations. II. Preparation of a human pituitary lipid-mobilizing factor (LMF) with hypocalcaemic and hyperglycaemic effects in rabbits.


Separation of water-soluble steroid and carotenoid precursors by DEAE-cellulose column chromatography.


A regenerating system for studies of phosphoryl transfer from ATP.


A factor for coupling NAD to hydrogenase in Hydrogenomonas eutropha.


Fluorescence of D-glyceraldehyde-3-phosphate dehydrogenase-substrate complexes.


Inhibition of the multiplication of Myxovirus and Arbovirus by chemically modified ribonucleic acids from the host cells.


Studies on alkaline phosphatase. Phosphorylation of calf-intestinal alkaline phosphatase by 32P-labelled pyrophosphate. 1. A purified preparation of alkaline phosphatase from calf-intestinal mucosa was phosphorylated by (32)P-labelled PP(i) at a serine residue on the enzyme. Under the conditions employed, up to 0.15mum-labelled sites were obtained from 1mum-[(32)P]PP(i). 2. The phosphorylated enzyme was labile, the rate of dephosphorylation being similar to the overall rate of substrate hydrolysis. 3. A stopped-flow technique was used to determine the number of phosphomonoesterase active sites, which agreed with the number of (32)P-labelled sites. 4. It is concluded that calf-intestinal alkaline phosphatase is both a phosphomonoesterase and a pyrophosphatase.


Mass-spectrometric evidence for methyl and ethyl esters of long-chain fatty acids in ox pancreas.


The isolation of rat liver plasma membrane fragments.


Glucose and mannose diphosphates in the red blood cell.


Glucose as a regulator of glycogen phosphorylase in rat diaphragm. II. Effect of glucose and related compounds on phosphorylase phosphatase.


The isolation of a mutant of Bacillus cereus deficient in phosphate uptake.


Acetylcholine-sensitivity of thalamic neurones: its relationship to synaptic transmission.


Iron utilization and metabolism in the chick.


Experimental studies of intralymphatic administration of radiotherapy with particular emphasis on lymphatic dynamics and lymph node response to lymphography.


Histochemical differentiation in beagle aorta.


Lymphographic evaluation of abnormal lymph flow in protein-losing gastroenteropathy secondary to chronic constrictive pericarditis.


99mTc pertechnetate scanning of salivary glands.


Cerebral synaptic transmission and behavioral effects of dimethoxyphenylethylamine: a potential psychotogen. Dimethoxyphenylethylamine, like mescaline which it resembles, impairs cerebral synaptic transmission and behavior in cats. It has properties associated with hallucinogens and, on this score, qualifies as a potential inducer of psychosis. The idea of such an endogenous inducer is thus reaffirmed by the candidacy of dimethoxyphenylethylamine.


Terminals of single Ia fibers: distribution within a pool of 300 homonymous motor neurons. The excitatory postsynaptic potentials produced in motoneurons by impulses in single afferent fibers (Ia) have been recorded with the aid of an averaging computer. These responses were used to map the distribution of the terminals of single fibers within the pool of 300 motoneurons of the medial gastrocnemius muscle. Twelve Ia fibers were studied in separate experiments. Monosynaptic excitatory postsynaptic potentials were found in 94 percent of the 77 motoneurons investigated. This finding indicates that each of the 300 motoneurons must receive afferent fibers from almost all of the spindles of the muscle it innervates.


Corticotrophin treatment in multiple sclerosis.


Lactate and pyruvate levels in blood, cerebrospinal fluid and brain tissue.


Zoster in children.

Zoster in children.


Herpesvirus hominis (simplex) infection with recurrences during infancy.


Ring-G chromosome, a new G-deletion syndrome?


Crystalline transfer factors from Escherichia coli.


The energy-dependent accumulation of phosphate by blowfly mitochondria and its effect on the rate of pyruvate oxidation.


The mechanism of action of CDP-glucose oxidoreductase.


Requirement of substrate for adenosine 5'-monophosphate binding to liver fructose 1,6-diphosphatase.


A re-evaluation of the fractionation of high molecular weight RNA by MAK chromatography.


Enzymatic solubilization of microsomal NADH-cytochrome b5 reductase by lysosomes.


Studies on the respiratory chain-linked reduced nicotinamide-adenine dinucleotide dehydrogenase. I. Effect of diethyl ether on particulate NADH dehydrogenase.


Induction of respiratory deficiency by repression of the respiratory system in a mutant of Saccharomyces cerevisiae.


Composition and properties of the membrane-bound respiratory chain system of Micrococcus denitrificans.


Light-induced electron transport in Chromatium strain D. I. Isolation and characterization of Chromatium chromatophores.


Electron paramagnetic resonance studies on photosynthetic bacteria. I. Properties of photo-induced EPR-signals of Chromatium D.


Light-induced electron transport in Chromatium strain D. II. Light-induced absorbance changes in Chromatium chromatophores.


Brain and consciousness.

Brain and consciousness.


Effects of cooling and rewarming on Na, K, and tension changes in rat tail artery.


Studies of the energy-transfer system of submitochondrial particles. I. Competition between oxidative phosphorylation and the energy-linked nicotinamide-adenine dinucleotide transhydrogenase reaction.


A polyribonucleotide containing alternation P=O and P=S linkages.


Studies of the energy-transfer system of submitochondrial particles. 2. Effects of oligomycin and aurovertin.


A review of the experimental aspects of Bell's palsy.


Problems relating psychological and electrophysiological observations in sensory perception.


Molecular mechanisms in learning.

Molecular mechanisms in learning.


Energy transfer in poly-l-tyrosine as a function of the degree of ionization of the phenolic hydroxyls. II. Electron spin resonance study of the triplet state.


The mechanism of internuclear transmission of SV40-induced complement fixation antigen in heterokaryocytes.


Effect of phenoxybenzamine on neural and humoral control of sweat glands.


In vitro cultivation of mouse mammary tumor virus: detection of MTV production by radioisotope labeling and identification by immune precipitation.


Evidence for large precursor proteins in poliovirus synthesis.


Clinical vestibular examinations and their results.


Theca cell tumor. An ultrastructural study.


The changing prognosis and treatment in cancer of the ovary. A report of 235 patients with primary ovarian carcinoma 1952-1961.


Synthesis of 4-O-beta-D-glucopyranosyl-D-xylose. 4-O-beta-D-glucopyranosyl-D-arabinose, 4-O-beta-D-glucopyranosyl-2-deoxy-D-glucose, 4-O-beta-D-glucopyranosyl-D-mannose, and 4-O-beta-D-glucopyranosyl-D-glucosamine by cellobiose phosphorylase from Clostridium thermocellum.


Pyridine nucleotide changes during thermogenesis in brown fat tissue in vivo.


Trihydroxycoprostanic acid from crocodilians.


The pathway of biosynthesis of nicotinamide-adenine dinucleotide in rat mammary gland. 1. The pathway of NAD synthesis in mammary gland was examined by measuring the activities of some of the key enzymes in each of the tryptophan, nicotinic acid and nicotinamide pathways. 2. In the tryptophan pathway, 3-hydroxyanthranilate oxidase and quinolinate transphosphoribosylase activities were investigated. Neither of these enzymes was found in mammary gland. 3. In the nicotinic acid pathway, nicotinate mononucleotide pyrophosphorylase, NAD synthetase, nicotinamide deamidase and NMN deamidase were investigated. Both NAD synthetase and nicotinate mononucleotide pyrophosphorylase were present but were very inactive. Nicotinamide deamidase, if present, had a very low activity and NMN deamidase was absent. 4. In the nicotinamide pathway both enzymes, NMN pyrophosphorylase and NMN adenylyltransferase, were present and showed very high activity. The activity of the pyrophosphorylase in mammary gland is by far the highest yet found in any tissue. 5. The apparent K(m) values for the substrates of these enzymes in mammary gland were determined. 6. On the basis of these investigations it is proposed that the main, and probably only, pathway of synthesis of NAD in mammary tissue is from nicotinamide via NMN.


Effect of a lipid extract of frog skin on short-circuit current and sodium transport of isolated frog skin.


A direct pathway for the conversion of propionate into pyruvate in Moraxella lwoffi. 1. The identity of the organism previously known as Vibrio O1 (N.C.I.B. 8250) with a species of Moraxella is established. 2. The ability of cells to oxidize propionate is present only in cells with an endogenous respiration and this ability is increased 80-fold when the organism is grown with propionate. 3. Isocitrate lyase activity in extracts from propionate-grown cells is the same as that in extracts from lactate-grown cells, about tenfold greater than that in extracts from succinate-grown cells and slightly greater than half the activity in extracts from acetate-grown cells. 4. With arsenite as an inhibitor conditions were found in which the organism would catalyse the quantitative oxidation of propionate to pyruvate. When propionate was completely utilized pyruvate was metabolized further to 2-oxoglutarate. 5. The oxidation of propionate by cells was incomplete both in a ;closed system' with alkali to trap respiratory carbon dioxide and in an ;open system' with an atmosphere of oxygen+carbon dioxide (95:5). Acetate accumulated. Under these conditions [2-(14)C]- and [3-(14)C]-propionate gave rise to [(14)C]acetate. The rate of conversion of [2-(14)C]propionate into (14)CO(2), although much less than the rate of conversion of [1-(14)C]propionate into (14)CO(2), was slightly greater than the rate of conversion of [3-(14)C]propionate into (14)CO(2). 6. The oxidation of propionate by cells was complete in an ;open system' with an atmosphere of either oxygen or air. Under these conditions very little [1-(14)C]propionate was converted into (14)C-labelled cell material. The conversion of [2-(14)C]- and [3-(14)C]-propionate into (14)C-labelled cell material occurred at an appreciable rate, the rate for the incorporation of [3-(14)C]propionate being slightly more rapid. In the absence of a utilizable nitrogen source part of the [(14)C]propionate was incorporated into some reserve material, which was oxidized when added substrate had been completely utilized. 7. [(14)C]-Pyruvate produced from [(14)C]propionate was chemically degraded. The C((1)) of propionate was found only in C((1)) of pyruvate. At least 86% of C((2)) of pyruvate was derived from C((2)) of propionate and at least 92% of C((3)) of pyruvate from C((3)) of propionate. 8. These results are incompatible with the operation of any of the previously described pathways for propionate metabolism except the direct one, perhaps via an activated acrylate.


Irreversible inactivation of (Na+-K+)-dependent ATPase and K+-dependent phosphatase by fluoride.


The conformation dependent hydrolysis of DNA by micrococcal nuclease.


Repression of isocitrate lyase synthesis in seeds germinated in the presence of glucose.


Degradation of thymus DNA and crab poly d(A-T) by micrococcal nuclease in the presence of actinomycin D.


The effect of 1,1,1-trichloro-2,2-bis(para-chlorophenyl)ethane on ribonucleic acid metabolism in Musca domestica L.


Evidence for dual physiological formsof ergosterol in Saccharomyces cerevisiae.


Comparison of the effect of the pyrogens, etiocholanolone and bacterial endotoxin on plasma cortisol and growth hormone in man.


Effect of estrogens on mature height in tall girls: a controlled study.


Clinical evaluation of urinary cortisol determinations by competetive protein-binding radioassay.


Growth hormone secretion enhanced by androgens.


Lysosomes in the spleen of the chick embryo. I. Description in the normal spleen.


Lysosomes in the spleen of the chick embryo. II. Changes during the graft-versus-host reaction.


Histological and histochemical observations of the hemolymph cells in the crayfish, Orconectes virilis.


Multiple primary carcinomas of the breast and stomach.


Insulin-secreting bronchial carcinoid tumor with widespread metastases.


Granular cell myoblastoma of the breast.


Herpes simplex virus infections of the nervous system. Problems in laboratory diagnosis.


Myotubular myopathy.

Myotubular myopathy.


Concentration of technectium 99m by the choroid plexus. Experimental demonstration in vivo.


The effect of triiodthyronine on neuromuscular junctions of isolated rat diaphragm.


Identification and estimation of tritium-labeled reserpine in biological material by a combination of thin-layer chromatography and liquid-scintillation radioassay.


Functional identity of rat-liver microsomal glucose 6-phosphatase and inorganic pyrophosphatase.


Renal effects of val 5-angiotensin 11-amide, vasopressin and diuretics in the rat, as influenced by water diuresis and by ethanol anesthesia.


Liver response tests. 8. Factors influencing the activities of liver-microsomal phosphatases.


Free radical yields in x-irradiated glycine peptides.


Effects of x-irradiation on the synthesis of rapidly labelled RNA in experimental tumour of the rat.


Free radical formation in a gamma-irradiated pyrimidine-purine co-crystal complex.


Case report: granular cell myoblastoma.

Case report: granular cell myoblastoma.


A note on foot and mouth disease. (Epizootic aphtha).


Nerve conduction and the effect of local anesthesia.


Skeletal maturation in juvenile diabetes mellitus.


A case of migratory intraocular foreign body.


Mechanism of action and metabolic fate of vitamin D.


Comparison of the in vitro cytology of hamster embryo cell lines transfored "spontaneously" or by SV40: with contrast of sarcomas induced in the homologous host.


Supporting role of the adrenal cortex in the induction of hyperfibrinogenemia.


Histidinaemia: a child and his family.

Histidinaemia: a child and his family.


Mixed tumors of human salivary gland. Histogenesis.


Serum folate and FIGLU excretion in patients with trophoblastic tumours.


Genetic and viral influences of mammary tumours in BR6 mice.


Routine preparation of silica gel media using silicate solutions of varying pH.


Interaction of some polyvinyl pyridine oxides with polysilicic acid and its relationship to their ability to inhibit silica fibrosis.


Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus.


Molecular conformation of thymidine and a comparison with some electron spin resonance results.


Identification of rhinovirus stran D.C.

Identification of rhinovirus stran D.C.


Neurotrophic control of contracture in slow muscle fibres.


Paget's disease of the vulva. Report of 10 cases.


Maternal urinary estriol excretion after dehydroepiandrosterone-sulfate infusion and adrenal stimulation and suppression.


The laboratory diagnosis of human parasitic amoebae.


Nasopharyngeal angiofibroma in the juvenile.


The influence of food intake and ergot alkaloids upon vagogenic atrioventricular heart block of the Wenckebach type.


The clinical significance of lymphatico-venous anastomosis. Its implications in lymphangiography.


Pregnancy following Wilms' tumor.

Pregnancy following Wilms' tumor.


Malignant tumors in smallpox vaccination scars: a report of 24 cases.


Cytochemical and ultrastructural studies of the intestinal mucosa of children with celiac disease.


Activity of enzymes in the endometrium, caruncles, and uterine rinsings of progestogen-treated and naturally cycling ewes.


Electric dipole theory of chemical synaptic transmission. In this paper we propose that chemicals such as acetylcholine are electric dipoles which when oriented and arranged in a large array could produce an electric field strong enough to drive positive ions over the junction barrier of the post-synaptic membrane and thus initiate excitation or produce depolarization. This theory is able to explain a great number of facts such as cleft size, synaptic delay, nonregeneration, subthreshold integration, facilitation with repetition, and the calcium and magnesium effects. It also shows why and how acetylcholine could act as excitatory or inhibitory transmitters under different circumstances. Our conclusion is that the nature of synaptic transmission is essentially electrical, be it mediated by electrical or chemical transmitters.


Changes in blood vessel permeability during degeneration and regeneration in peripheral nerves.


The enzymatic assay of pyruvic and lactic acids. A definitive procedure.


An improved method for measuring human blood bile acids.


The relationship of NADH-dependent diaphorase activity and methemoglobin reduction in human erythrocytes.


Two-deimensional thin-layer chromatography of neuraminic acid-containing lipids.


The metabolism of glyoxylate in blood from normal subjects and patients with primary hyperoxaluria.


Electrophoretic characterization of amebal glucose phosphate isomerases.


Metabolism of Plasmodium berghei. I. Krebs cycle.


A study of bacteria and lethal factors in fluids from experimental intestinal obstruction in dogs.


The foot and mouth disease virus content of guinea-pig epidermis after mechanical injury.


Influence of irradiation on the susceptibility of the guinea-pig to infection with Clostridium welchii type A.


Further investigations on enterovirus-neutralising substances in human and animal sera.


Structure and function of mitochondria in crithidia fasciculata.


Mouse hyperaemic corpora lutea assay of prolcatin.


Prevention of bacteriuria resulting from indwelling catheters.


Bistability caused by substrate inhibition of peroxidase in an open reaction system.


Pressure effects on survival of mice with transplantable leukaemia.


Amino-acid composition of "Tubulin" constituting microtubules of sperm flagella.


A case of congenital epulis.

A case of congenital epulis.


The nurse as a central figure in a medical health center.


Analysis of the 5'-terminal nucleotide sequences of ribonucleic acids. II. Comparison of the 5'-terminal nucleotide sequences of ribosomal RNA's from different organisms.


Herpes simplex encephalitis.

Herpes simplex encephalitis.


Measurement of plasma cortisol in the diagnosis of Cushing's syndrome.


Smallpox studies in Madras City, India.

Smallpox studies in Madras City, India.


Comparative studies of cell-culture-propagated avian pox viruses in chickens and turkeys.


Susceptibility of turkeys to infectious laryngotracheitis.


Infectious disease exposure in a wild turkey population.


Focal degenerative myopathy in turkeys.

Focal degenerative myopathy in turkeys.


A case of pancreatic disease with peptic ulceration.


Polynucleotidase activity of animal and plant tissue phosphodiesterases.


Enzymatic oxidation of 14C-labelled betaine by the marine microbe Achromobacter cholinophagum.


Liver glucokinase of the biotin deficient rat.


The chain termini of polynucleotides formed by limited enzymic fragmentation of wheat embryo ribosomal RNA. 1. Studies of snake venom phosphodiesterase.


Acute leukemias and Burkitt's lymphoma. Present status of therapy.


Host defenses in leukemia and Burkitt's tumor.


Tumors of the kidney in cattle, sheep and pigs.


The parafollicular cells of the thyroid gland as a possible site of production of thyrocalcitonin. An electron microcopic examination of the thyroid gland of the rat after stimulation by calcium acetate and vitamin D3.


The cells of Cajal-Retzius in the developing human brain.


Changes in adrenocortical responsiveness to ACTH infusion in aging goats.


A simple twenty-four hour test to evaluate hypothalamus-pituitary-adrenal cortical function.


Cytology of cerebrospinal fluid in the diagnosis of malignancy.


Stimulation of the cat stellate ganglion by angiotensin.


On the presence of a renin-like activity in erythropoietin preparations.


Electromechanical and pharmacomechanical coupling in vascular smooth muscle.


Hirano J, Masson GM: Effects of dietary sodium on hypertensive disease caused by renin.


Islet cell tumor in the neonate. Studies in carbohydrate metabolism and therapeutic response.


Inflammatory pseudotumors of the lung: a report of two cases and brief review of the literature.


False adrenergic transmitter release from the isolated cat heart.


Tritiated folic acid (H F.A.). Excretion tests for the study of folic acid absorption.


Effect of some drugs on p-nitrophenylphosphatase activity in brain and live tissue of the rat with special reference to influence of phenothiazines on membranes of brain tissue.


Studies in hypophosphatasia and response to high phosphate intake.


A pox disease in monkeys transmitted to man. Clinical and histological features.


Auditory function and lesions of the pons.


Successful total adrenal autotransplantation into the spleen of dogs.


A serological survey of mucosal disease and infectious bovine rhinotracheitis in cattle in Australia and New Guinea.


Suspected adenovirus bronchitis in Arab foals.


Canine distemper.

Canine distemper.


The influence of cyclic 3', 5'-AMP and theophylline on oxygen consumption of rats.


Base sequence differences between the ribosomal and "ribosomal precursor" ribonucleic acids from Ehrlich ascites cells.


The filipin complex.

The filipin complex.


Erythritol metabolism by Propionibacterium pentosaceum. The role of L-erythrulose 1-phosphate.


Light-induced free radicals of retinal, retinol, and rhodopsin.


A study of the conformational properties of bovine pancreatic ribonuclease A by electron paramagnetic resonance.


Mechanisms of steroid oxidation by microorganisms. 13. C22 acid intermediates in the degradation of the cholesterol side chain.


Mechanisms of steroid oxidation by microorganisms. XIV. Pathway of cholesterol side-chain degradation.


Steroid treatment in the nephrotic syndrome in childhood.


Synacthen Depot--Adrenal response in normal subjects and corticotrophin-treated patients.


Inhibition of eledoisin by morin on the isolated guinea pig ileum.


Patterns of three-dimensional growth in vitro in collagen-coated cellulose sponge: carcinomas and embryonic tissues.


Electron spin resonance studies of photo-sensitized decomposition of methyl alcohol in the presence of p-benzoquinone.


Proprties of ATP-ase of the BAI strain A virus. 3. Relationship of ATP-ase to the active transport of sodium and potassium ions.


Antigens of the liver plasma membranes and mouse hepatoma.


Comparative study of mouse leukaemias induced by Mazurenko, Friend and Graffi viruses, using the in vitro cytotoxic test.


Biological oxidations and energy conservation.


Characterization of a herpes-like virus recovred from Burkitt lymphoma cells(P3-J) and propagated in dog thymus cells. 1. An electron microscope study.


Lysosomes in the spleen of the chick embryo. I. Description in the normal spleen.


Characterization of a herpes-like virus recovered from Burkitt lymphoma cells(P3-J) and propagated in dog thymus cells. 1. An electron microscope study.


Observations on the transformation of human amnion cell cultures by simian virus 40.


Biological behavior through successive transplant generations of transplantable tumors derived originally from primary chemically induced and spontaneous sources in mice.


Characteristics of the in vitro assay of murine sarcoma virus (Moloney) and virus-infected cells.


Observations on the nature of the herpes-type EB virus in cultured Burkitt lymphoblasts, using a specific immunofluorescence test.


Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation.


Questions of hospital patients--unasked and unanswered.


Evaluation of management and therapy of the mentally retarded.


Response of Ips confusus to synthetic sex pheromones in nature. The first flight response of bark beetles to synthetic sex pheromones under natural conditions is reported. Two insect species predaceous on this bark beetle also responded. The synthetic compounds delivered in an airstream from a substrate of Carbowax 20M on Chromosorb A appear to elicit the same response as the natural attractant from male-infested bolts of ponderosa pine elicits.


The regulation of aldosterone secretion by the renin-angiotensin system under various conditions.


Mycoplasma pharyngeal flora in civilians.


Bronchial arterial perfusion with cytotoxic agents for bronchogenic carcinoma. Preliminary report.


Tumours of salivary glands. A review of 204 cases with 5-year follow-up.


The stability of the protective antigen and histamine-sensitizing factor of Bordetella pertussis to acid and alkali.


Lipohyperplasia of the ileocecal valve.

Lipohyperplasia of the ileocecal valve.


Susceptibility of various types of cell cultures to three strains of bovine parainfluenza 3 virus.


Feline viruses. I. Characterization of four isolates and their effect on young kittens.


The effect of 5-iodo-2'-deoxyuridine on the multiplication of infectious bovine rhinotracheitis virus.


Studies on the mechanism of antilipolytic action of prostaglandin E1.


Inhibition of fatty acid stimulation of gluconeogenesis by (+)-decanoylcarnitine in perfused rat liver.


Role of the redox state of nicotinamide adenine dinucleotides in the regulation of metabolic processes.


The activation and inactivation of muscle phosphorylase.


Deoxycorticosterone secretion in chronic experimental heart failure and during infusion of angiotensin II.


Effects of antilymphocyte serum on virus oncogenesis.


Influence of mammary tumor virus infection on the acceptance or rejection of transplanted ML+ leukemias.


Serologic screening of rhesus and grivet monkeys for SV40 and the foamy viruses.


Efficacy of interferon in the treatment of mice with established Friend virus leukemia.


Further purification of a human placental inhibitor to hemagglutination by H-1 virus.


Poliovirus replication and cytopathogenicity in monolayer hamster cell cultures fused with beta propiolactone-inactivated Sendai virus.


Stimulatory effects of insulin and glucagon on phenylethanolamine-N-methyl transferase of rat adrenal.


Rhinoviruses: the isolation and characterization of three new serologic types.


Rate of disappearance of exogenous dog renin from the plasma of nephrectomized dogs.


Fatal bronchial asthma: an analysis of terminal treatment in twenty cases.


Comparison of reagent-impregnated paper strips and conventional methods for identification of Enterobacteriaceae.


The pathogenesis of peritoneal adhesions: an ultrastructural study.


Effect of cigarette smoke on resistance to respiratory infection.


A clinical, roentgenological, and physiological study of magnetite workers.


Pulmonary hazards of lymphography.

Pulmonary hazards of lymphography.


Clinical and experimental studies of pulmonary oil embolism.


Pulmonary function studies.

Pulmonary function studies.


Effect of variola and vaccinia viruses on the mitosis of cultured human amnion cells.


Sero-epidemiologic studies of Sendai virus infection on Taiwan.


Changes in the cortical thickness of the clavicle according to age.


Experimental hypertrophic neuropathy: an electron microscope study.


Arterial catecholamine and enzyme histochemistry in migraine.


Immunization by selective infection with type 4 adenovirus grown in human diploid tissue cultures. I. Safety and lack of oncogenicity and tests for potency in volunteers.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 19-1968.


Demonstration by plaque reduction technique of immunologic relationship between canine herpes virus and herpes simplex virus.


Effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus.


Antibody to rhinovirus in human sera. I. Standardization of a neutralization test.


Antibody to rhinovirus in human sera. II. Heterotypic responses.


Classification of the neuromuscular disorders. Appendix A to the Minutes of the Meeting of the Research Group on Neuromuscular Diseases, held in Montreal, Canada, on 21 September, 1967.


Pressor response to angiotensin II in hypertension. Correlation with plasma renin activity and response to norepinephrine and metaraminol.


Glial-nodule encephalitis associated with generalized cytomegalic inclusion body disease.


Fine structure of herpes simplex virus hepatoadrenal necrosis in the newborn.


[3H]uracil accumulation in motor neurons compared with that occurring in blocks of nerve tissue, liver, muscle and plasma in the rat.


A general procedure for degrading radioactive aldoses.


An evaluation of alumni group psychotherapy: for patients discharged from a group living program.


A new serologic test for adenovirus infection.


Immunosuppression during acute murine cytomegalovirus infection.


N-terminal disulphide knot of human fibrinogen.


Fate of angiotensin I in the circulation.


Wide distribution of leukaemia virus in strains of laboratory mice.


The effects of pyrrolizidine alkaloids and d-tubocurarine on mitochondrial metabolism.


Immune response of chickens following heat exposure or injections with ACTH.


Free and conjugated steroid estrogen fractions of hens' urine.


Recurrent cranial nerve palsies of dysglobulinaemic origin.


Liver opacification following lymphangiography: Pathogenesis and clinical significance.


Influence of adrenocorticotrophic hormone on the DNA synthesis of epidermal and gastrointestinal cells in the mouse.


Trnasglucosyl-amylase of Candida tropicalis. Transglucosyl-amylase was purified 96-fold and partially characterized. The K(m) value with dextrin as substrate was 9.1 mg/ml. Glycerol, an acceptor of d-glucose, appeared to inhibit dextrin hydrolysis noncompetitively. The energy of activation of the enzyme was 7,920 cal/mole. Indirect determinations showed that synthesis of d-glucosyl glycerol was significantly affected by the nature of the amylaceous substrate. Glucosyl-glycerol synthesis did not increase as incubation temperature was raised from 50 to 60 C. Direct determinations by gas-liquid chromatography indicated that the synthesis of glucosyl glycerol, as a function of the concentration of either enzyme, substrate, or glycerol, traced a curvilinear path approaching 15 mg/ml as the maximum. When enzyme, substrate, and glycerol at high concentrations were varied in all possible combinations, however, conditions for producing as much as 47.5 mg/ml of glucosyl glycerol were established.


Synergism between hyperoxia and antibiotics for Pseudomonas aeruginosa. Three strains of Pseudomonas aeruginosa were directly exposed on the surface of membrane filters to hyperoxic atmospheres. One of the three strains was found to be sensitive to oxygen. Colonies failed to appear during 18 hr of incubation in pure oxygen at 1 atm, but about 40% of the bacteria recovered to produce colonies upon reincubation in air. Similar killing was produced by 10 hr of oxygen exposure. No inhibition or killing was observed with two other strains. Streptomycin (1mug/ml) and kanamycin (5mug/ml) were more effective in killing the oxygen-sensitive strain in the presence of 60 to 70% oxygen than in air, but polymyxin B (5mug/ml) did not show a synergistic effect under such conditions.


Stimulation by phenethyl alcohol of aerobic fermentation in Mucor rouxii.


A split pathway of electron transport in mitochondria.


Aldolase isozymes in rat tumor cells.

Aldolase isozymes in rat tumor cells.


An improved synthesis of isopentenyl pyrophosphate. 1. Isopentenol was converted into isopentenyl phosphate with phosphoryl chloride in ether containing pyridine. 2. The isopentenyl phosphate reacted in 2-methylpropan-2-ol-water with morpholine and dicyclohexylcarbodi-imide to give isopentenyl phosphoromorpholidate. 3. The isopentenyl phosphoromorpholidate, with inorganic phosphate in pyridine containing tributylamine, gave isopentenyl pyrophosphate. The yield of pyrophosphate from monophosphate was 80-85% and the yield of pyrophosphate from isopentenol 40-60%. [1-(14)C]-Isopentenyl pyrophosphate was prepared by this method. 4. The yield of isopentenyl pyrophosphate from isopentenyl phosphate was substantially improved, in comparison with the yields obtained by published methods via the phosphoramidate, by the use of the phosphoromorpholidate.


Subcellular distribution of cytochrome c in rat liver. Methods for its extraction and purification. 1. A method for the extraction and purification of cytochrome c from rat liver is described. The method depends on multiple chromatography on Amberlite IRC-50 with elution with ammonium phosphate buffers of differing ionic composition and pH, interspersed with gel filtration with Sephadex G-25. Conditions leading to denaturation are avoided and the product is chromatographically pure. 2. The method may be used for the quantitative analysis of cytochrome c either in unfractionated liver or in subcellular fractions. 3. Two pools of cytochrome c were detected, one extractable at pH4.0 with distilled water and the other extracted from the residues of the first extraction with 0.15m-sodium chloride. 4. For subcellular distribution studies the liver was homogenized in 0.3m-sucrose and a nuclear fraction (washed thoroughly to remove trapped mitochondria), a mitochondrial fraction, a heavy microsomal fraction, a standard microsomal fraction and the cell sap were isolated. The mitochondrial fraction was subfractionated further by density-gradient centrifugation. Each fraction was analysed for protein, RNA, DNA, succinate-neotetrazolium oxidoreductase and glucose 6-phosphatase. 5. A total of 123mug. of cytochrome c was obtained/g. wet wt. of rat liver. 6. Values for the percentage subcellular distribution of cytochrome c are: nuclear fraction, 24.4; mitochondrial fraction, 57.2; heavy microsomal fraction, 5.2; standard microsomal fraction, 10.6; cell sap, 2.7. 7. Three out of the eight mitochondrial subfractions separated by gradient centrifugation contained 76% of the cytochrome c and 85% of the succinate-neotetrazolium oxidoreductase present in the mitochondrial fraction. 8. In unfractionated liver 94% of the cytochrome c was extracted at pH4.0 with water whereas in most of the subcellular fractions the corresponding value was approx. 75-80%.


Studies on glycogen synthesis in pigeon liver homogenates. Glycogen synthesis from glucose monophosphates and uridine diphosphate glucose. Comparative time-course studies of glycogen synthesis from glucose 6-phosphate, glucose 1-phosphate and UDP-glucose show that glucose 1-phosphate forms glycogen at an initial rate faster than that obtained with glucose 6-phosphate and UDP-glucose. After 5min. the rates from glucose monophosphates are considerably slower. 2,4-Dinitrophenol decreases glycogen synthesis from both glucose monophosphates, whereas arsenate and EDTA increase glycogen synthesis from glucose 1-phosphate and inhibit the reaction from glucose 6-phosphate, galactose and galactose 1-phosphate. Mitochondria-free pigeon liver cytoplasmic fraction forms less glycogen from glucose monophosphates than does the whole homogenate. 2-Deoxyglucose 6-phosphate inhibits glycogen synthesis from glucose monophosphates. Glycogen formation from UDP-glucose is relatively unaffected by dinitrophenol, by arsenate, by EDTA, by 2-deoxyglucose 6-phosphate and by the removal of mitochondria from the whole homogenate.


Effect of mercurial compounds on structure-linked latency of lysosomal hydrolases. 1. A partially purified lysosomal preparation was obtained from adult mouse livers by sucrose-density-gradient centrifugation of a large-granule fraction. 2. This lysosome-enriched subfraction was contaminated approx. 10% by mitochondrial cytochrome c oxidase and malate dehydrogenase. 3. Free acid phosphohydrolase and beta-glucuronidase contributed less than 10% of the total (Triton X-100-solubilized) activity in contrast with approx. 30% free N-acetyl-beta-d-glucosaminidase when assayed in an iso-osmotic incubation system. 4. Exposure of the lysosomal preparation to inorganic Hg(2+) ions and organic mercurials (p-chloromercuribenzoate, phenylmercuric acetate) induced an irreversible loss of structure-linked latency with resulting enzyme activation. 5. Maximal activation was related to log [Hg(2+)] and pH. The response was all-or-none for individual particles; the dose-response curve portrayed the variation in particle resistance within the lysosomal population. 6. l-Cysteine and GSH totally prevented Hg(2+) ion-induced hydrolase activation. Ascorbate provided approx. 50% protection. 7. The three lysosomal hydrolases were differentially activated at constant [Hg(2+)], suggesting a different pattern of binding, unique for each enzyme studied.


Changes in hepatic lipigenesis during development of the rat. 1. Changes in the activities of ATP citrate lyase, ;malic' enzyme, glucose 6-phosphate dehydrogenase, pyruvate kinase and fructose 1,6-diphosphatase, and in the ability to incorporate [1-(14)C]acetate into lipid have been measured in the livers of developing rats between late foetal life and maturity. 2. In male rats the activities of those systems directly or indirectly concerned in lipogenesis (acetate incorporation into lipid, ATP citrate lyase and glucose 6-phosphate dehydrogenase) fall after birth and are maintained at a low value until weaning. After weaning these activities rise to a maximum between 30 and 40 days and then decline, reaching adult values at about 60 days. ;Malic' enzyme activity follows a similar course, except that none could be detected in the foetal liver. Pyruvate kinase activity is lower in foetal than in adult livers and rises to slightly higher than the adult value in the post-weaning period. Fructose 1,6-diphosphatase activity rises from a very low foetal value to reach a maximum at about 10 days but falls rapidly after weaning to reach adult values at about 30 days. 3. Weaning rats on to a high-fat diet caused the low activities of acetate incorporation, ATP citrate lyase, glucose 6-phosphate dehydrogenase and pyruvate kinase, characteristic of the suckling period, to persist. ;Malic' enzyme and fructose 1,6-diphosphatase activities were not altered appreciably. 4. No differences could be detected in hepatic enzyme activities between males and females up to 35 days, but after this time female rats gave higher values for acetate incorporation, glucose 6-phosphate dehydrogenase activity and ;malic' enzyme activity. 5. The results are discussed in relation to changes in alimentation and hormonal influences.


Nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria. Purification and properties. 1. A method of stabilizing the enzyme by using glycerol is described. 2. A purification procedure is presented giving a higher purification than previously described. 3. Data showing substrate activation and activation by citrate are presented. 4. Kinetic constants for NAD(+), NADH and certain bivalent metal ions are given. 5. Pronounced inhibitory buffer effects are described. 6. A brief comparison between the NAD-specific isocitrate dehydrogenase from peas and that from other sources is made.


The separation of vanillate O-demethylase from protocatechuate 3,4-oxygenase by ultracentrifugation. 1. Protocatechuate 3,4-oxygenase in the soluble part of a cell-free extract of Pseudomonas fluorescens (strain T) sedimented more rapidly than vanillate O-demethylase under specified conditions in a preparative ultracentrifuge. 2. The supernatant from this process contained vanillate O-demethylase and formaldehyde dehydrogenase, and when supplemented with NADH oxidized vanillate with an uptake of 1 mole of oxygen/mole of substrate and accumulation of protocatechuate. 3. This uptake was decreased to 0.5mole/mole of substrate in the presence of semicarbazide as trapping agent for formaldehyde. 4. Reasons are presented for the process of methyl group removal from vanillate being oxidative demethylation.


Quantitative analysis of simple lipid classes by thin-layer chromatography.


Enzymatic hydrolysis of sphingolipids. VII. Hydrolysis of gangliosides by a neuraminidase from calf brain.


Metabolic changes during phosphate deprivation in euglena in air and in oxygen. 1. Euglena cells were grown in culture media containing either 20mm-phosphate or 20mum-phosphate, with ethanol or glucose as the sole source of carbon, and gassed with either air+carbon dioxide (95:5) or oxygen+carbon dioxide (95:5) at atmospheric pressure. 2. After growth in low-phosphate medium with ethanol as substrate, the cells developed signs of oxygen toxicity, as indicated by a decreased rate of respiration, a decreased net synthesis of paramylum and a failure to resume growth on replenishment of phosphate. 3. After growth in low-phosphate medium with glucose as substrate, the signs of oxygen toxicity were less apparent. 4. During phosphate deprivation the carotenoid content of Euglena increased more than threefold. This increase was largely prevented by exposure of the cells to oxygen+carbon dioxide (95:5) during growth. Oxygenation appears to interfere with ring closure of the common carotenoid precursor. 5. Mitochondria obtained from Euglena exposed to oxygen during phosphate deprivation, i.e. when signs of oxygen toxicity were evident, had greatly decreased activities of succinate dehydrogenase, succinate-cytochrome c oxidoreductase and NADH-cytochrome c oxidoreductase, compared with mitochondria obtained from Euglena exposed to oxygen in medium containing 20mm-phosphate.


Spin-labelled lipid-protein complexes.

Spin-labelled lipid-protein complexes.


Glycolipids containing glucose and uronic acids in Pseudomonas species.


Alterations in the molecular species of rat liver lecithin by corn-oil feeding to essential fatty acid-deficient rats as a function of time.


Studies on sphingosines. XIV. On the phytosphingosine content of the major human kidney glycolipids.


Effects in vitro and in vivo of synthetic phosphatidate phosphatase inhibitors.


Phospholipids in tissues of the eye. I. Isolation, characterization and quantitative analysis by two-dimensional thin-layer chromatography of diacyl and vinyl-ether phospholipids.


Phospholipids in the tissues of the eye. II. Composition and incorporation of 32Pi of phospholipids of normal rat and calf lens.


Plasma angiotensinase activity in relation to the breakdown of phenylthiocarbamyl-angiotensin II amide in hypertensive and normotensive patients.


Blood angiotensinase activity in relation to the breakdown of angiotensin II amide and nonisotopic phenylthiocarbamyl-angiotensin II amide in hypertensive and normotensive patients.


Origin of urinary enzymes hydrolysing beta-naphthylamides of L-leucine and L-glutamic acid.


The deposition of lipid and the composition of neutral lipids in the fat body of Sarcophaga bullata (Diptera).


The carotenoid pigments of Daphnia magna Straus. I. The pigments of animals fed . Chlorella pyrenoidosa and pure carotenoids.


Composition of plasma lipoproteins of the spiny dogfish Squalus acanthias.


Nucleotide sequence homologies in nuclear and cytoplasmic ribonucleic acid from rat liver and hepatomas.


Thin-layer chromatography of some trimethylsilylated carbohydrates.


The effect of methoxy substitution and configuration on the thin-layer chromatographic behaviour of some closed E ring oxindole alkaloids.


Tritium detection by beta-radioluminescence in standard media for thin-layer chromatography.


Thin-layer chromatography and determination of thiamine salts, phosphoric esters, disulphides, and their respective thiochromes.


Automatic chromatographic analysis of the dinitrophenylene and dinitrophennyl derivatives of lysine and tyrosine.


Development and localization of virus-specific antigens during the multiplication of herpes simplex virus in BHK 21 cells.


Recombination between conditional lethal mutants within a strain of foot-and-mouth disease virus.


Analysis of molluscum-induced interference in mouse embryo cells: growth of encephalomyocarditis virus and dose-response relationships in molluscum-inhibited cultures.


Electron microscopy of poliovirus antigen antibody precipitates extracted from gel diffusion plates.


The nucleic acid of Sendai virus and ribonucleic acid synthesis in cells infected by Sendai virus.


A cytochemical comparison between the activity of lactic dehydrogenase-diphosphopyridine nucleotide-diaphorase system in the testis and epididymis compared to some semen characteristics.


Quantitative histochemical analysis of glycolytic intermediates and cofactors with an oil well technique.


The site of ferricyanide reduction by reductases within mitochondria as studied by electron microscopy.


Effect of 1-beta-D-arabinofuranosylcytosine on DNA synthesis. II. In rabbit kidney cells infected with herpes viruses.


Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse.


Epidemiologic features of trophoblastic disease.


Hirsutism and benign androgenic hyperplasia of the adrenals.


Studies of the biosynthesis of polymyxin B.


Giant nonfunctioning islet cell tumor. Survival after pancreaticoduodenectomy.


Interaction between colloidal montmorillonite and cells of Rhizobium species with different inogenic surfaces.


Control of muscle glycogen phosphorylase activity by insulin.


Activities of glycolytic enzymes during the early stages of differentiation in the cellular slime mold Dictyostelium discoideum.


Two forms of copper (II) in fungal laccase.


A comparative study of the regulation of nicotinamide-adenine dinucleotide biosynthesis.


Mechanism of formation of sulphhaemoglobin.


Autonomic involvements in polyneuritis and its related disorders.


Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3',5'-monophosphate, and theophylline. The effect of prostaglandin E(1) (PGE(1)) on the water permeability response to vasopressin, theophylline, and cyclic adenosine 3',5'-monophosphate (C-AMP) of isolated, perfused collecting tubules of the rabbit was investigated in vitro. Prostaglandin is a naturally occurring substance present in a number of tissues, including kidney. It has been implicated in the action of a variety of hormones, many of which are known to exert their physiological effects through the intermediacy of the C-AMP system. In the collecting tubule, PGE(1) (10(-7) M) elicited a minimal increase in net water absorption along an osmotic gradient. However, when administered in association with a concentration of vasopressin (2.5 muU ml(-1)) selected to induce a submaximal increment in water absorption, the effect of the latter was reduced by approximately 50%. Theophylline (5 x 10(-3) M) also increased net water absorption, an effect not previously demonstrated in renal tissue. This effect was potentiated by the simulataneous addition of PGE(1). In contrast, PGE(1) did not influence the increase in net water absorption induced by C-AMP (10(-2) M). Since C-AMP is responsible for the permeability effects of vasopressin in renal tissue, the present results are consistent with the view that PGE(1) interferes with the action of the octapeptide by competing with it at a site which influences the generation of C-AMP. In addition it is proposed that prostaglandin may be an important modulator of the action of vasopressin. The tubule is exquisitely sensitive to the hormone, responding to as little as 0.25 muU ml(-1). It is conceivable that in the intact animal prostaglandin may serve to dampen the effects of small amounts of residual hormone and thereby prevent overshoots in permeability which might otherwise occur.


Distribution of phosphatases in the golgi region and associated structures of the thoracic ganglionic neurons in the grasshopper, Melanoplus differentialis. The neuronal perikarya of the grasshopper contain sudanophilic lipochondria which exhibit an affinity for vital dyes. These lipochondria are membrane-delimited and display acid phosphatase activity; hence they correspond to lysosomes. Unlike those of most vertebrates, these lysosomes also hydrolyze thiamine pyrophosphate and adenosine triphosphate. Like vertebrate lysosomal "dense bodies," they are electron-opaque and contain granular, vesicular, or lamellar material. Along with several types of smaller dense bodies, they are found in close spatial association with the Golgi apparatus. The Golgi complexes are frequently arranged in concentric configurations within which these dense bodies lie. Some of the smaller dense bodies often lie close to or in association with the periphery of dense multivesicular bodies. Further, bodies occur that display gradations in structure between these multivesicular bodies and the dense lysosomes. Acid phosphatase activity is present in the small as well as the larger dense bodies, in the multivesicular bodies, and in some of the Golgi saccules, associated vesicles, and fenestrated membranes; thiamine pyrophosphatase is found in both the dense bodies and parts of the Golgi complex. The close spatial association of these organelles, together with their enzymatic similarities, suggests the existence of a functional or developmental relationship between them.


Electron microscopic and biochemical characteristics of nuclei and nucleoli isolated from rat liver. Rat liver nuclei were freed of cytoplasmic contamination by washing with Triton-X-100 and subsequent centrifugation through 2.2 M sucrose. Electron microscopic examination showed that the outer membranes of the nuclei had been removed, but that the nuclei otherwise resembled the nuclei of intact liver. Morphological studies, chemical estimations of DNA, RNA, and protein and the estimation of cytoplasmic "marker" enzymes suggested that contamination of nuclei by cytoplasmic components was limited. These nuclei were obtained in yields of about 70% and were suitable for the isolation of nucleoli. Nucleoli were isolated by the breaking of the nuclei by ultrasound and subsequent differential centrifugation. In ultrastructural appearance, the isolated nucleoli resembled nucleoli in intact tissue. However, at high magnifications the "granular" component of isolated nucleoli appeared to consist of tightly twisted fibers. The nucleoli could be obtained in yields of at least 30%, and the values for the chemical composition of the isolated nucleoli agreed with values previously reported.


Primary malignant osseous and soft tissue tumors.


Late effect of estrogen on endotoxin response in the rat.


A concentrated psychiatric placement program: first six months' evaluation.


Sperm-agglutinating autoantibodies in relation to male infertility.


Cytopathologic changes of lymphatic tissues of cattle with the bovine virus diarrhea-mucosal disease complex.


The release of noradrenaline by the sympathetic post-ganglionic nerves to the spleen of the cat in response to low frequency stimulation.


Eye signs in patients with Cushing's syndrome and pituitary tumors.


Transient postictal hemianopsia.

Transient postictal hemianopsia.


The inhibition of yeast alcohol dehydrogenase by 2-bromo-2-phenylacetaldehyde.


Studies on the thyroidal UDPG pyrophosphorylase: partial purification and some of its properties.


Some esterases of the pea (Pisum sativum L.).


Studies on the ribonuclease activity of Proteus mirabilis.


The non-specific nature of the nucleoside diphosphatase of rat liver microsomes.


Purification and properties of ATP-sulphate adenylyltransferase from liver.


Control of succinate oxidation by succinate-uptake by rat-liver mitochondria.


The action of phospholipase A on the plasma membranes of rat liver cells.


The phosphoinositide inositolphosphohydrolase of guinea-pig intestinal mucosa.


Biological regulation of liver microsomal inorganic pyrophosphate-glucose phosphotransferase, glucose 6-phosphatase, and inorganic pyrophosphatase. Differential effects of fasting on synthetic and hydrolytic activities.


Ribosomal change in liver after partial hepatectomy and acute stress.


Purification and properties of a bovine adrenal 21-dehydrosteroid reductase.


Spectrophotometric identification of an active site-specific acyl glyceraldehyde 3-phosphate dehydrogenase. The regulation of its kinetic and equilibrium properties by coenzyme.


Food poisoning caused by heat-sensitive Clostridium welchii. A report of five recent outbreaks.


The isolation and characterization of foot-and-mouth disease virus from clinically normal herds of cattle in Botswana.


Lack of adaptation in lipogenesis by hepatoma 9121. The "minimal deviation" hepatoma 9121, implanted in rats, was shown to biosynthesize fatty acids from acetate-1-(14)C at the same rate as normal rat liver but faster than host liver. Feeding the host animals a fat-deficient diet caused fatty acid biosynthesis to be increased 3- to 13-fold in liver, but the dietary regimen did not influence fatty acid biosynthesis in the tumor tissue. Oxygen consumption and the oxidation of acetate and mevalonate to CO(2) were all affected by the dietary manipulation in liver but not in hepatoma. The fat-deficient diet decreased incorporation of acetate and mevalonate into cholesterol by the liver of control animals, increased it in the liver of host animals, and had no effect on this process in hepatoma. Thus, the transplantable tumor has lost the adaptive power of its parent tissue to respond to the dietary stimulus. The changes in fatty acid composition in total lipids in response to the fasting and refeeding were also markedly different in hepatoma from those in liver of the host animals. These results support the concept that this tumor is characterized by a loss of some metabolic controls.


The sarcomatous transformation of mammary carcinoma of mice in isologous transplantates, in cell culture, and in reimplantates.


Tumour induction in the rat by a mixture of two non-carcinogenic aminoazo dyes.


Recent experience with major hepatic resection.


Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle.


Studies on the mode of action of clofibrate: effects on hormone-induced changes in plasma free fatty acids, cholesterol, phospholipids and total esterified fatty acids in rats and dogs.


Plasma esterase and acid ribonuclease following the injection of heparin in dogs.


Separation of cholesterol esters. A comparison between paper and thin layer chromatography.


Comparison of column, thin-layer and paper chromatography of oxidized alkyl oleates.


A method for the determination of plasma renin activity in small samples.


Peripheral entrapment neuropathies.

Peripheral entrapment neuropathies.


Inhibition of the phosphodiesterase activity of commercial E. coli phosphatase.


Come down to earth and warm the soup.

Come down to earth and warm the soup.


Meeting "the increasing demand for the educated nurse".


Granulosa-theca cell tumors. A clinical review of 102 patients.


Gallamine (Flaxedil) and synaptic transmission in the spinal cord. A paralyzing dose of gallamine (Flaxedil) (1 to 2 milligrams per kilogram of body weight) has no effect on synaptic transmission in the cat's spinal cord. In spinal cats ventilated with oxygen, we stimulated a dorsal spinal root and recorded the compound ventral root potential. The reflex potential was not affected by 6.25 milligrams of gallamine per kilogram. Giving 12.5 milligrams of gallamine per kilogram had no significant effect on the monosynaptic spike height, but the polysynaptic response rose briefly to 12 percent above control. Increased magnitude of the polysynaptic response appeared related to a concomitant rise in blood pressure.


"Tactile" stimulus intensity: information transmission by relay neurons in different trigeminal nuclei. Comparison of the information transmitted about the intensity of a steady "tactile" stimulus applied to facial skin by single trigemino-thalamic neurons in nucleus oralis and nucleus caudalis indicates that little information loss occurs at the medial lemniscal synaptic relay (nucleus oralis), but that it is gross within the nucleus caudalis.


Neurologic disorders in renal failure.

Neurologic disorders in renal failure.


Accuracy and value of needle biopsy of the parotid gland.


Hypoglycemia in Meniere's disease.

Hypoglycemia in Meniere's disease.


Pathologic quiz case 2.

Pathologic quiz case 2.


The thymus and the pituitary-adrenal axis in anencephaly. A correlation between experimental foetal endocrinology and human pathological observations.


Comparative studies of type 1 and type 2 & 'herpes simplex' viruses.


Enzymatic synthesis of glycerol 1-phosphate (D-alpha-glycerophosphate). Inorganic pyrophosphate-glycerol phosphotransferase and inorganic pyrophosphate-glucose phosphotransferase compared.


Homocitrate formation in Neurospora crassa. Relation to lysine biosynthesis.


General nature of "Wurster's blue shunts" in the respiratory chain.


Vitamin B 12 biosynthesis. Evidence for a new precursor vitamin B 12 5'-phosphate.


Relationship of injury to chemical carcinogenesis in the lungs of rats.


Immunochemical studies on human lung cancer antigens soluble in 50 per cent saturated ammonium sulfate.


Mechanism of induction of ovarian tumors in the mouse by 7,12-dimethylbenz[a]anthracene. 3. Tumor induction in organ culture.


Hepatotoxic and carcinogenic effects of dimethylnitrosamine in low dosage. Light and electron microscopic study.


Enhancing effect of a riboflavin analog on azo-dye carcinogenesis in rats.


In vitro viral transformation of chemically transformed cells.


Erythritol metabolism by Propionibacterium pentosaceum. The over-all reaction sequence.


Behaviour and morphology of pregnancy responsive mammary tumours in mice.


Nephrotic syndrome in children.

Nephrotic syndrome in children.


Chacko-Nair egg-enriched selective medium in the diagnosis of pathogenic Neisseriae.


Norethisterone jaundice in two sisters.

Norethisterone jaundice in two sisters.


VI. Chemical transmission at the neuromuscular junction: concepts and consequences.


3. Interaction of psychotropic drugs with agents employed in clinical anesthesia.


Cultivation of fused cells resulting from treatment of cells with HVJ. II. Division of binucleated cells resulting from fusion of two KB cells by HVJ.


The binding of DNA to residual protein in mammalian nuclei.


The effect of cortisone on glucose-6-phosphatase during development.


Studies with carcinogens and tumor-promoting agents in cell culture.


Selective effects of L-fucose on BHK21 hamster fibroblasts and on BHK21 cells transformed by infections with polyoma virus.


Initiation of bacterial spore germination. To investigate the problem of initiation in bacterial spore germination, we isolated, from extracts of dormant spores of Bacillus cereus strain T and B. licheniformis, a protein that initiated spore germination when added to a suspension of heat-activated spores. The optimal conditions for initiatory activity of this protein (the initiator) were 30 C in 0.01 to 0.04 m NaCl and 0.01 m tris(hydroxymethyl)aminomethane (pH 8.5). The initiator was inhibited by phosphate but required two co-factors, l-alanine (1/7 of K(m) for l-alanine-inhibited germination) and nicotinamide adenine dinucleotide (1.25 x 10(-4)m). In the crude extract, the initiator activity was increased 3.5-fold by heating the extract at 65 C for 10 min, but the partially purified initiator preparation was completely heat-sensitive (65 C for 5 min). Heat stability could be conferred on the purified initiator by adding 10(-3)m dipicolinic acid. A fractionation of this protein that excluded l-alanine dehydrogenase and adenosine deaminase from the initiator activity was developed. The molecular weight of the initiator was estimated as 7 x 10(4). The kinetics of germination in the presence of initiator were examined at various concentrations of l-alanine and nicotinamide adenine dinucleotide.


K+-stimulated phosphatase of microsomes from gastric mucosa.


The relation of karyotypic change to loss of contact inhibition of division in human diploid cells after SV40 infection.


Nuclear fraction of Bacillus subtilis as a template for ribonucleic acid synthesis. A "nuclear fraction" prepared from Bacillus subtilis was a more efficient template than purified deoxyribonucleic acid for the synthesis of ribonucleic acid by exogenously added ribonucleic acid polymerase isolated from B. subtilis. The initial rate of synthesis with the nuclear fraction was higher and synthesis continued for several hours, yielding an amount of ribonucleic acid greater than the amount of deoxyribonucleic acid used as the template. The product was heterogenous in size, with a large portion exceeding 23S. When purified deoxyribonucleic acid was the template, a more limited synthesis was observed with a predominantly 7S product. However, the ribonucleic acids produced in vitro from these templates were very similar to each other and to in vivo synthesized ribonucleic acid as determined by the competition of ribonucleic acid from whole cells in the annealing of in vitro synthesized ribonucleic acids to deoxyribonucleic acid. Treatment of the nuclear fraction with heat (60 C for 15 min) or trypsin reduced the capacity of the nuclear fraction to synthesize ribonucleic acid to the level observed with purified deoxyribonucleic acid.


Studies on carcinogenesis by avian sarcoma viruses. VI. Differential multiplication of uninfected and of converted cells in response to insulin.


The interaction of closed circular DNA with intercalative dyes. I. The superhelix density of SV40 DNA in the presence and absence of dye.


Early and late helix-coil transitions in closed circular DNA. The number of superhelical turns in polyoma DNA.


Pathophysiology of hypertension.

Pathophysiology of hypertension.


Renal-pressor hypertension secondary to unilateral hydronephrosis.


Association of cytomegalovirus infection with the postperfusion syndrome.


The influence of L-thyroxine on the metabolism of ethanol in rat liver.


Bioassay of prolonged corticotropin preparations, with the international working standard on living guinea pigs.


Experimental studies on continuous or intermittent selective brain cooling by means of carotico-carotid shunt in dogs, especially on the application of polarographic measurement in the prevention of cerebral anoxia.


Left ventricular function in children studied by increasing peripheral resistance with angiotensin.


An early stage in the comparison of methods of modification of a field strain of foot-and-mouth disease, type A (Turkey 19-64).


An extra-adrenal response to sodium loading revealed by thymectomy.


Recent developments in the therapy of gout.


Interference in  modified foot-and-mouth disease viruses.


Typing of the foot-and-mouth disease virus. Result of diagnosis and typing of foot-and-mouth disease virus.


Studies on cell-reaction of the nasal epithelium during the fusion to palatine shelves.


Plasma renin activity after bleeding in rats with transected or destroyed medulla spinalis.


Correlation of transmitter release with membrane properties of the presynaptic fiber of the squid giant synapse. Depolarization of the presynaptic terminal by current produced a postsynaptic potential (PSP) which increased with increasing presynaptic polarization and then reached a plateau. Iontophoretic injection of tetraethylammonium ions (TEA) into the presynaptic axon near the terminal produced a prolonged presynaptic spike. The resulting PSP is increased in size and its time course closely followed that of the presynaptic spike. The presynaptic fiber no longer exhibited rectification and strong depolarizations revealed that the PSP reached a maximum with about 110 mv depolarization. Further depolarization produced a decrease in PSP amplitude and finally transmission was blocked. However, a PSP then always appeared on withdrawal of the depolarizing current. Under the conditions of these experiments, the PSP could be considered a direct measure of transmitter release. Bathing the TEA-injected synapse with concentrations of tetrodotoxin (TTX) sufficient to block spike activity in both pre- and postsynaptic axons did not greatly modify postsynaptic electrogenesis. However, doubling TTX concentration reversibly blocked PSP. Thus the permeability changes to Na and K accompanying the spike do not appear necessary for transmitter release. Some other processes related to the level of presynaptic polarization must be involved to explain the data. The inhibition of transmitter release by strong depolarizations appears to be related to Ca action. A membrane Ca current may also be necessary for normal transmitter release.


Transmission of somatic sensory volleys through ascending spinal hindlimb pathways during sleep and wakefulness.


Effects of angiotensin and noradrenaline on flow and composition of the renal lymph.


The lectins of some Polish plants. IV. Effect of sodium periodate.


Krukenberg tumour primary in the jejunum. A case report.


Mechanisms of interaction between a phosphoinositide anticoagulant and a phospholipid activator in the Stypven type conversion of prothrombin to thrombin.


Branchial cleft remnants suggesting tuberculous lymphadenitis.


Multicentric reticulohistiocytosis. Report of a case with histochemical studies.


Erythema elevatum diutinum.

Erythema elevatum diutinum.


Extramammary Paget's disease.

Extramammary Paget's disease.


Some biophysical properties of a vibriophage and its DNA.


Phenethyl alcohol: reversible inhibition of synthesis of macromolecules and disaggregation of polysomes in rat hepatoma cells.


Cooperative study on cardiac catheterization. Complications involving the nervous system.


Cooperative study on cardiac catheterization. Summary.


Immunochemical study of beta-corticotropin-(1-24)-tetracosa-peptide.


Experimental studies in mice on the late effects of radioactive and nonradioactive contrast media.


The active sequence in the ACTH molecule responsible for inhibition of the extinction of conditioned avoidance behaviour in rats.


Hypersensitivity olipid mobilizing agents in essential fatty acid (EFA) deficient rats.


[Plasmatic adrenocorticotropin activity in patients treated with ultrasonic therapy of the pituitary gland according to the Arslan method].


E.S.R. spectra of free radicals induced in nucleic acid purine and pyrimidine bases and selected analogues by exposure to hydrogen atoms.


Effects of whole-body irradiation and radio-mimetic chemicals on the acid RNAse and phosphodiesterase levels of rat intestinal homogenate.


Quantitative thin-layer chromatography of trimethylsilyl ethers of hydroxylic steroids.


The effect of methoxy substitution and of configuration on the thin-layer chromatographic behaviour of some heteroyohimbine alkaloids.


Chromatography of beta-carbolines.

Chromatography of beta-carbolines.


Detection of rearrangement reactions by silver nitrate thin-layer chromatography.


Concerning thin-layer electrophoresis of carbohydrates.


Standardization of aqueous silicic acid for thin-layer chromatography.


A screening technique for indian hemp (Cannabis sativa L.).


The separation of ten tobacco alkaloids by thin-layer chromatography.


Separation of the pyridine-monocarboxylic and 2-pyridine-dicarboxylic acids by two-dimensional ion-exchange thin-layer chromatography.


Identification of the nitrate esters of five alkyl alcohols by thin-layer chromatography.


XIX. Paper chromatographic identification of sphingomyelins and their N-acyl derivatives.


Biochemistry of sphingolipids. XX. Chromatographic identification of the erythro configuration of sphingosine bases isolated from human brain sphingomyelins.


Effects of furosemide uring antidiuresis and antinatriuresis induced by angiotensin.


NMR spectroscopy of methyl derivatives of galactose.


On the possible involvement of charge transfer complexes (redox systems) in radioprotection.


Prerequisites for the natriuretic effect of val-5-angiotensin II amide in the rat.


Metabolic adaptations to chronic heat exposure in the golden hamster.


Effect of hormones on ceruloplasmin and copper concentrations in the plasma of the rat.


Acid-base behavior of separated canine renal tubule cells.


Antibody patterns of parainfluenza viruses in human populations on Taiwan.


Steroidogenic response in normal dogs receiving blood from dogs with caval constriction.


Fractionation of Bacillus subtilis DNA by use of poly-L-lysine kieselguhr columns.


Deaminase activity of commercial spleen phosphodiesterase.


Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics.


Gradation of specificity with regard to sugar among nucleases.


Selenium as an acid labile sulfur replacement in putidaredoxin.


Carcinoma of the breast. Histologic and clinical features of apocrine tumors.


Alteration in liver lipid and lipid fatty acid composition after partial hepatectomy in the rat.


Natural activators for liver fructose 1,6-diphosphatase and the reversal of adenosine 5'-monophosphate inhibition by muscle phosphofructokinase.


Studies on nucleolar 4 to 6 S ribonucleic acid of Novikoff hepatoma cells.


Control of glycogenolysis in the toad's urinary bladder. The effect of anaerobiosis, sodium transport, and arginine vasotocin.


Chemistry and metabolism of 3-deoxy-D-mannooctulosonic acid. I. Stereochemical determination.


Release of prostaglandin from rat epididymal fat pad on nervous and hormonal stimulation. Acidic lipids with smooth muscle-stimulating properties were extracted from rat epididymal fat pads and were shown to co-chromatograph with (PGE1) prostaglandin E1, PGE2, and PGF2alpha.  Further chemical identification was not possible with the small amounts of material available.  A basal efflux of PGE and PGF compounds was observed following incubation of adipose tissue in vitro.  Increased efflux of PG was detected under conditions reported to enhance free fatty acid release, i.e., addition of lipolytic hormones or drugs to the incubating medium, prior fasting of the animal, or stimulation of the epididymal nerve.  These results, together with a decreased release of PG-like material in the presence of insulin, suggested that the efflux may be associated with lipolysis resulting from activation of a hormone-sensitive lipase.  Since the PGs are known to affect the concentration of cyclic adenosine 3', 5'-monophosphate in adipose tissue, and this nucleotide is an intermediary in hormone-stimulated lipolysis, it is possible that the PGs released may serve to maintain the homeostasis of adipose tissue by way of a physiological feedback control mechanism.


Rapid labeling of mitochondrial lipids by labeled orthophosphate and adenosine triphosphate.


Acyl dihydroxyacetone phosphate. Characterization of a 32P-labeled lipid from guinea pig liver mitochondria.


Neonatal infection caused by adenovirus type 7.


A search for the reservoir of cytomegalovirus in salivary gland tissue.


Respiratory processes in brown adipose tissue.


The incidence of cytomegaloviruria and postmortem cytomegalic inclusions in children with acute leukemia.


Effect of exogenous dopamine on rat adrenal ascorbic acid.


Studies on the radiocalcium uptake and the adenosine triphosphatases of skeletal and cardiac sarcoplasmic reticulum fractions (SRF).


Blood flow and free fatty acid release from the epigastric adipose tissue of rabbits.


Mechanism of action of norepinephrine in eliciting an eating response on injection into the rat hypothalamus.


A dual effect of calcium ions on neuromuscular facilitation. 1. The changes in neuromuscular facilitation produced by varying extracellular calcium and magnesium concentrations have been studied at the frog neuromuscular junction using intracellular recording and automatic averaging of responses.2. When [Ca] was elevated three effects were observed: a large increase in transmitter release by the first impulse; a decrease in facilitation at short intervals between impulses; and a prolongation of the time course of the facilitated release. If the release by the first impulse is kept at constant level, by raising both [Ca] and [Mg], facilitation becomes greater at all impulse intervals.3. The results have been discussed in terms of the hypothesis that the action of calcium is responsible for neuromuscular facilitation.


The role of calcium in neuromuscular facilitation. 1. The hypothesis is put forward that a residue of the ;active calcium' which enters the terminal axon membrane during the nerve impulse is responsible for short-term facilitation.2. This suggestion has been tested on the myoneural junction by varying the local calcium concentration so that during the first of two nerve impulses [Ca](o) is either much lower than, or raised to a level approaching that, during the second impulse. Facilitation is much larger in the latter case, which is in accordance with the ;calcium hypothesis'.3. A short pulse of depolarization focally applied to the junction is followed by a brief period of very intense facilitation. This can be seen in the tetrodotoxin-treated preparation, e.g. by lengthening the depolarization from 1 to 2 msec which can cause a more than fifty-fold increase in transmitter release. This large ;early facilitation' (which presumably occurs also during the course of a normal action potential) is discussed in relation to the ;calcium hypothesis'.


Prolonged remissions in acute myelocytic leukemia in adults.


Combined liver-kidney isotope scans. Diagnosis of abdominal masses in children.


Toxoplasma gondii and cytomegalovirus: mixed infection by a parasite and a virus. Human fibroblasts infected in vitro with cytomegalovirus are relatively resistant to infection by Toxoplasma gondii during the first 4 days of virus infection. After 5 days, however, the cytomegalovirus-infected cells become susceptible to the parasites. The toxoplasmas replicate in paracentral rosettes surrounded by host cell mitochondria. This growth configuration differs from that seen in human fibroblasts infected in vitro with toxoplasma only but resembles the pattern seen in doubly infected cells found in human necropsy tissue.


Induction of an inhibitor of influenza virus hemagglutination by treatment of serum with periodate. Serum is commonly treated with potassium periodate to destroy nonspecific inhibitors of influenza virus hemagglutination. We have observed, however, that such treatment of serum without pre-existing inhibitor produced high titers of inhibitor against certain strains of influenza virus. Inhibitor was induced in the serum from several different animal species but not in hamster or mouse serum. Periodate treatment of serum albumin, fraction V, from several animals, including man, creates this inhibitor. Our data indicate that the inhibitor induced in the serum of various animal species differs in its mechanism of induction and in its resistance to receptor-destroying enzyme and trypsin. Hemagglutination by B/Singapore/3/64, B/Colorado/2/65, B/Georgia/1/65, and B/Massachusetts/3/66 strains of influenza virus is inhibited by periodate-treated human serum at dilutions as high as 1:5,120. The routine use of periodate treatment of serum in diagnostic and surveillance studies of influenza virus infections is not recommended.


Hyperinsulinism. Surgical results and management of occult functioning islet cell tumor: review of 154 cases.


Effects of bilateral adrenalectomy and continuous light on the circadian rhythm of corticotropin in female rats.


Fibrinoid necrosis of placental villi.

Fibrinoid necrosis of placental villi.


Effects of cortisone on renal sodium excretion in rabbits.


Orf. Report of 19 human cases with clinical and pathological observations.


The pathology of renal cancer.

The pathology of renal cancer.


Stellate ganglionic transmission and myocardial contractile force during halothane anesthesia.


The unique association between salivary gland cancer and breast cancer.


Electromyography in collagen disease.

Electromyography in collagen disease.


Antihypertensive actions of diuretics. Comparative study of an aldosterone antagonist and a thiazide, alone and together.


Plasma levels of ACTH and cortisol in man during diethyl ether anesthesia and surgery.


Intestinal alkaline phosphatase activity in familial hypophosphatasia.


Neuroendocrine reactions and the radiation-induced variations in rat intestinal alkaline ribonuclease levels.


ESR studies of spin transfer in irradiated nucleic acid--cysteamine systems.


Agent of disease contracted from green monkeys. An infectious agent obtained from patients who became ill after exposure to tissues of African green monkeys is viral in character. By electron microscopy, the agent appeared cylindrical, 90 to 100 nanometers in diameter, and 130 to 2600 nanometers in length. Cross-striations at 5-nanometer intervals and a core diameter of 45 nanometers were observed. The agent was completely resistant to the effects of the metabolic inhibitor 5-bromodeoxyuridine, which may mean that RNA is the genetic material. It was sensitive to ether and relatively sensitive to destruction by heat.


Discussion of the natural history of vesicular stomatitis.


Genetic changes in attenuated poliovirus strains cultivated on human intestine in vitro.


Serodifferentiation of type 3 poliovirus strains isolated 1960-1965 from patients and healthy vaccinees. Characterization of strains associated with disease in vaccinated persons and household contacts.


Viruses and disease. II. An outbreak of parainfluenza Type 2 in a children's home.


The safety of human diploid cell strains for man: a controlled study of symptoms occurring after the administration of WM-3 living attenuated poliovirus vaccine prepared in the WI-38 human diploid cell strain.


Rhinovirus infections in a student population: isolation of five new serotypes.


Public health nursing in California State Hospitals for the mentally retarded.


Pathology of vestibular disorders vertigo of peripheral origin: histopathology.


Official statement. The Doman-Delacato treatment of neurologically handicapped children.


Gas gangrene in abdominal surgery.

Gas gangrene in abdominal surgery.


The influence of cortisol and adrenocorticotropic hormone on the sedimentation rate of the red blood cells.


The incidence of buccal pigmentation in caucasoids and negroids in Britain.


Oral herpetic infection in adults. Clinical, histological and cytological features.


Multiple granular-cell myoblastoma (schwannoma) in a child.


Adenomatoid ameloblastoma. An analysis of nine cases by histopathological and electron microscopic study.


Some electrophysiological methods for studying the action of narcotic agents in animals, with special reference to industrial solvents: a review.


Ultrastructure of myoepithelial cells in human mammary gland tumors.


Studies on infectious mononucleosis. 3. Clinical data, serologic and epidemiologic findings.


Inflammatory pseudotumors of the stomach. Follow-up report and correction.


Embryonic ependymoma arising in a cerebral hemisphere.


Embryonal rhabdomyosarcoma. An ultrastructural study.


Cystosarcoma phylloides. An ultrastructural study.


Malignant mixed tumors of the major salivary glands. Special reference to the histologic structure in metastases.


Secretion of various endocrine substances by ACTH-secreting tumors--gastrin, melanotropin, norepinephrine, serotonin, parathormone, vasopressin, glucagon.


Mixed differentiation of primary carcinoma of the urinary bladder.


Influence of pituitary, thyroid, and adrenal hormones on norepinephrine turnover and metabolism in the rat heart.


Clinical assessment of growth-rate in human tumours.


Incidence of Clostridium perfringens in fish and fish products.


Hemadsorption by herpes simplex-infected cell cultures.


Electron paramagnetic resonance studies on melanins. I. The effect of pH on spectra at Q band.


A hexacoordinated low-spin cobalt(II) complex.


Transplantability of cycasin-induced tumors in rats, with emphasis on nephroblastomas.


Long-term propagation of a murine erythroblastosis virus in vitro.


Influence of host genotype on responses to four strains of avian leukosis virus.


Secretion of cortisol, corticosterone and aldosterone in children with hypopituitarism.


The ultrastructure of human mixed salivary tumors.


Intermittent corticosteroid treatment of demyelinating diseases in childhood.


Blastomogenic effect of dimethylnitrosamine on pregnant rats and their offspring.


Abortive transformation by polyoma virus.


Cerebellar responses evoked by somatic afferent volleys during sleep and waking.


Tonic and phasic changes in threshold of arousal during desynchronized sleep.


Transmission of sensory information throug ascending spinal hindlimb pathways during sleep and wakefulness.


A superior thin-layer chromatographic procedure for the separation of aza arenes and its application to air pollution.


Phospholipids of human hair lipids.

Phospholipids of human hair lipids.


The detection of diethylstilboestrol (DES) in urine by thin-layer chromatography.


A common solvent impurity resembling a tocopherol.


Thin-layer chromatographic separation and detection of methysergide and methergine.


The identification of some amino acids in the presence of 50 percent glycerol, on silica gel thin layers.


Determination of the degradation products of ethylenebis(dithiocarbamates) by thin-layer chromatography and some investigations of their decomposition in vitro.


The in vivo effect of ACTH on the activity in lipase in rat adrenal.


Two pathways transmitting vestibulospinal influences from the lateral vestibular nucleus of Deiters to Extensor Fusimotor Neurones.


A serologic survey for arbovirus antibodies in inhabitants of a southwest Taiwan village.


Control by factors in serum of multiplication of uninfected cells and cells infected and converted by avian sarcoma viruses.


A growth regulating factor in rat liver.


Polyneuropathy in children.

Polyneuropathy in children.


Skeletal development as a measure of biological development.


Skeletal age of children with congenital heart disease.


The influence of embryonic tissue on growth of transplantable chrysoidin hepatoma.


Studies on the adaptive properties of CoxsackieA4 viruses.


Effect of long-term administration of ACTH and adrenocortical hormones on the course of hydrazide convulsions.


Influence of drugs, rate changes and temperature on myocardial stimulation by hypoxia.


Infectious RNA derived from bovine virus diarrhoea virus.


Life threatening disease. An unusual case of severe burns, meningitis, obstructive hydrocephalus and neuroblastoma in a child under age two.


Cystic disease of liver and kidney with portal hypertension. A cause of sudden unexpected hematemesis.


Behcet's syndrome with neurological manifestations in two sisters.


Angiography in abdominal tumours in childhood with particular reference to neuroblastoma and Wilms' tumour.


The mechanism of end product inhibition of serine biosynthesis. II. Optical studies of phosphoglycerate dehydrogenase.


The mechanism of end product inhibition of serine biosynthesis. 3. Physical and chemical properties of phosphoglycerate dehydrogenase.


Location of chromophoric residues in proteins by solvent perturbation. IV. Tyrosyl residues in ribonuclease.


Activation of skeletal muscle phosphorylase kinase by adenosine triphosphate and adenosine 3',5'-monophosphate.


Studies on the phospholipid requirement of glucose 6-phosphatase.


Reversal of phosphorylase kinase activation.


The anaerobic incorporation of 32P into adenosine triphosphate by Hymenolepis diminuta.


The effect of cysteine on L-alpha-glycerophosphate and lactate dehydrogenase reactions.


Kinetics and substrate binding of myosin adenosine triphosphatase.


The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate.


Purification and properties of citraconase.


An electron paramagnetic resonance study of the iron and copper complexes of transferrin.


A comparison of glycopeptides derived from soluble and insoluble collagens.


Kinetic studies on the mechanism of the malate dehydrogenase reaction.


Reconstitution of the mitochondrial oxidation chain from individual components.


Conditioned glycemic responses in the control of food intake.


Oxidative phosphorylation in mitochondria of developing rat brain.


Granular cell myoblastoma: report of case.


Linitis plastica associated with complete situs inversus. Report of a case.


Acute nephritis presenting with a normal urine. Report of a case.


Cardiovascular actions of guancydine in normotensive and hypertensive animals.


Ultracytochemical changes of the glucose-6-phosphatase (D-glucose-6-phosphate phosphohydrolase) activity in liver cells of the rat treated with phenobarbital.


Salvage of "sleeve-like" amputation of a digit.


Hepatography with oily contrast medium injected via the portal vein system.


A change in growth potential of cells after conversion by Rous sarcoma virus.


Nuclear RNA patterns in rat liver and hepatomas.


Carcinoid of the bronchus.

Carcinoid of the bronchus.


Comparative chronic toxicity of three oral estrogens in rats.


Evidence for the presence of 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphoran-2-one in cat intestine following tri-o-cresyl phosphate administration.


Trophoblastic diseases in Taiwan.

Trophoblastic diseases in Taiwan.


Control of fatty acid synthesis in homogenate preparations of mouse hepatoma BW 7756.


The oxidation of horseradish peroxidase by periodate.


Glycogen synthesis and I to D conversion of glycogen synthetase in ascites hepatoma cells.


The effect of catecholamines on the adenyl cyclase of frog and tadpole hemolysates.


Comparative histochemical distribution of glycogen and alkaline phosphatases in the placenta.


Acute infectious bovine rhinotracheitis and salmonellosis in a dairy herd.


Oxidative phosphorylation in Micrococcus denitrificans. 3. ATP-supported reduction of NAD+ by succinate.


Lipids of Streptomyces sioyaensis.

Lipids of Streptomyces sioyaensis.


Development of hepatic lesions in calves fed with ragwort (Senecio jacobea).