Chromatographic analysis of neomycin. Isolation and identification of minor components.


An electron-microscopic study on morphological changes of Staphylococcus aureus treated with spiramycin.


Viral hepatitis in pregnancy.

Viral hepatitis in pregnancy.


An observation on the study of resistance of Culex pipiens fatigans (Wied) collected from Calcutta against DDT.


Studies on actinocarcin, a new antitumor antibiotic.


Structure of antibiotic A 25822 B, a novel nitrogen-containing C28-sterol with antifungal properties.


Outpatient morbidity statistics and cost on drugs per illness episode from Kaira Rural District (Gujarat) (study of a 5% sample of illness episodes).


Studies on some epidemiological and public health aspects of salmonellosis.


Multifactorial study of the risk of prematurity at 32 weeks of gestation. I. A study of the frequency of 30 predictive characteristics.


Multifactorial study of the risk of prematurity at 32 weeks of gestation. II. A comparison between an empirical prediction and a discriminant analysis.


The relationship of the size of the lumbar spinal canal to the symptomatology of prolapsed lumbar intervertebral discs.


The fate of the child after threatened abortion.


Combined use of amnioscopy and amniocentesis in the surveillance of twin pregnancy.


Neurogenic pulmonary oedema in the course of increased intracranial pressure.


Vertebral echinococcosis.

Vertebral echinococcosis.


Quantitative relationships between slowing of the fetal heart rate and changes in base-excess in the second stage of labor.


Uterine blood flow, oxygen uptake, and vascular resistance of pregnant sheep near term.


Massive intramedullary hemorrhage in a patient on anticoagulants. Case report.


Computer prediction of neonatal conditions by sampled data analyses of the fetal heart rate and the scalp blood during labor.


A combined clinical-biochemical scoring of the newborn: results of the past four years.


Human placental lactogen levels in the serum during early pregnancy.


Local gigantism of the hand associated with a plexiform neurofibroma of the ulnar nerve. Report of a case.


Cerebral reactions to intrauterine asphyxia in the sheep. III. Effects of alterations of hematocrit and viscosity.


One case report of quadriparesis from tuberculous infection of the cervical spine.


The effect of Th 1165a upon the reactivity of placental vessels in vitro.


The uterine and maternal placental blood flow during hyperoxia.


Thermography of the rat brain under massive increase in intracranial pressure.


The influence of hypoxia on uterine and maternal placental blood flow, and the effect of alpha-adrenergic blockade.


Creatinine levels in first urines of male preterm and term infants.


No differences in benzo(a)pyrene hydroxylase activity in the human immature placenta and in the human fetal liver from cigarette smoking and nonsmoking women.


Prediction of perinatal mortality in early pregnancy.


The fetal magnetocardiogram.

The fetal magnetocardiogram.


Structural classification of the obstetric part of perinatal medicine. International discussion of a medical-political question.


Perinatal medicine in Sweden.

Perinatal medicine in Sweden.


Development of perinatology: the prospects and prerequisites.


Thoughts on future structure of perinatal medicine.


Gynecology, obstetrics and perinatal medicine.


Intravenous glucose tolerance test and its relation to a scoring system for the degree of diabetic fetopathy in newborn infants.


An attempt at blocking the cardiovascular and metabolic side-effects of beta-mimetic drugs during labor.


Computed dip-parameters derived from digitized FHR-curves. I. The describing parameters and the method of digitizing.


Computed dip-parameters derived from digitized FHR-curves. II. The value of descriptive parameters.


Computed dip-parameters derived from digitized FHR-curves. III. The valuating parameter.


A comparative study of the epidemiological data of pregnancies with and without tendencies to premature delivery.


Synthetic turf and grass: a comparative study.


Osteochondritis of the capitellum.

Osteochondritis of the capitellum.


The meniscus as a cruciate ligament substitute.


The shoulder in sports.

The shoulder in sports.


Head injuries in athletics.

Head injuries in athletics.


Pes anserinus transplant: impressions after a decade of experience.


Ebow injuries in highly skilled tennis players.


Letter: Acromioclavicular dislocation.

Letter: Acromioclavicular dislocation.


Letter: Steroid injections.

Letter: Steroid injections.


Little league shoulder: lesions of the proximal humeral epiphyseal plate.


North Carolina high school football injury study: equipment and prevention.


Spearing: clinical consequences in the adolescent.


Little league shoulder: rotational stress fracture of proximal epiphysis.


Letter: Pre-season examination.

Letter: Pre-season examination.


An avoidable soccer injury.

An avoidable soccer injury.


Letter: Synthetic turf and grass.

Letter: Synthetic turf and grass.


The biomechanics of children's ski bindings.


Underwater bradycardia.

Underwater bradycardia.


Participation of the epileptic child in contact sports.


Injuries to runners.

Injuries to runners.


Proper playing conditions.

Proper playing conditions.


Investigation of scuba deaths.

Investigation of scuba deaths.


Function of the cruciate ligaments in knee stability.


The shoe-surface interface and its relationship to football knee injuries.


Traumatic bursitis and artificial turf.

Traumatic bursitis and artificial turf.


The coach's finger.

The coach's finger.


A carbon technique for half-tone drawing.


An improved method of taping. An interposition material allows extended use of adhesive tape in a sports medicine setting.


Tennis elbow: a biomechanical approach.

Tennis elbow: a biomechanical approach.


Some aspects of medical cinematography. Master cutting and commentary recording.


Ski injuries and equipment function.

Ski injuries and equipment function.


Water skiing hazards: nature and prevention.


Second annual meeting of the American Orthopaedic Society for Sports Medicine.


A simple method for producing high-quality corrosion casts.


A systematic approach to colour photomicrography. 1. The microscope: its optics and alignment.


Endurance performance as a function of prior-exercise heart rate.


A variable interval and duration warning system.


A simple flash bracket for the medical Nikkor lens.


Embryological reflections.

Embryological reflections.


Medical illustration in the new health service. 3. Eggheads or ploughmen?


The etiology and treatment of tennis elbow.


A biomechanical study of rabbit patellar tendon: effects of steroid injection.


Acute occlusion of the subclavian vein in an athlete: diagnosis, etiology and surgical management.


Premature physical deterioration: a reversible disease.


Preparing portable exhibitions.

Preparing portable exhibitions.


Introduction to scuba diving.

Introduction to scuba diving.


Postgraduate medical television at London University.


A technique for recording bite marks for forensic studies.


Helical instability of the knee: a concept and surgical reconstruction.


A systematic approach to colour photomicrography. 2. Cameras and photographic techniques.


Injuries of wrestling.

Injuries of wrestling.


Low power photomicrography and photomacrography using the Nikon Multiphot system.


Auxiliary cylindrical lenses for recording bands in narrow tubes.


Plexiglass cone.

Plexiglass cone.


Is hospital democracy possible? Problems in the therapeutic community as it reflects the community-at-large.


Social psychiatry and the prevention of mental hospital stay.


The rights of the mentally ill in Iran.

The rights of the mentally ill in Iran.


A microangiographic and histologic study of the kidney in Kimmelstiel-Wilson disease.


Clinical, epidemiological and sero-virological studies on rubella.


Ultrasonic blood rheography in vertebral artery of vertigo patients (Doppler method)--with the glass model experiments.


Experiences in pancreaticoduodenectomy. Preoperative devices and operative measures.


Evaluation of external cranial decompression for traumatic acute brain swelling.


The effect of sample preparation on the result of the hemolytic test.


Relationship between the structure and biocompatibility of hydrophilic gels.


Testing of new materials for their blood clotting properties by the in vitro method.


Silicones for medical applications.

Silicones for medical applications.


Complication after alloplastic thigh augmentation.


Past, present, and future of single needle dialysis (snd).


The renal microangiopathy of the hemolytic-uremic syndrome in childhood.


Safe efficient pediatric dialysis using a new variable size disposable dialyzer.


Effect of antilymphocyte globulin on platelets.


Acute renal failure following aortic aneurysm surgery.


The role of inhibitors of heme synthesis and bone marrow erythroid colony forming cells in the mechanism of anemia of renal insufficiency.


The effect of histidine supplementation on the anemia of uremia.


Assessment of central nervous system function in uremia.


Assessing adequacy of dialysis using measures of neurologic function.


Adverse effects of large surface area dialysis on motor nerve conduction velocity.


Cyanate: a potential uremic toxin.

Cyanate: a potential uremic toxin.


Parathyroidectomy as treatment for a-v block in chronic dialysis patients.


Effect of calcium and parathyroidectomy on gastrin and parathyroid hormone levels in dialysis patients.


Bioelectrical impedance during renal dialysis.


Use of intermittent pneumatic compression in hemodialysis.


Reuse of the model 4 Cordis Dow artificial kidney (CDAK-4).


Similarity of the dialysance of endogenous aryl acids and O-iodohippurate (hippuran) in uremic man.


Plasma as a source of hepatitis B on hemodialysis unit.


Individualized, quantified dialysis therapy of uremia.


Role of potassium in the regulation of aldosterone secretion in man.


Mechanism of actions of immunosuppressive drugs.


Hypernatremic, hyperosmolar coma complicating chronic peritoneal dialysis.


Cytotoxic drugs in primary glomerular disease.


Treatment of lupus nephritis.

Treatment of lupus nephritis.


Introduction to conference topic: opportunities for change in mental health services.


Elements of a comprehensive psychiatric service.


Initial psychiatric care outside the hospital.


Psychiatry in the general hospital and the day hospital.


Prisons, shelters, and homeless men.

Prisons, shelters, and homeless men.


Geriatric psychiatry.

Geriatric psychiatry.


The organization of a psychogeriatric service.


Occupational rehabilitation, day centers and workshops.


Occupational rehabilitation, day centers, and workshops.


A housing association for psychiatric patients.


Alternatives to the mental hospital-a British model.


Tropical eosinophilia.

Tropical eosinophilia.


Filariasis.

Filariasis.


Mechanisms regulating the membrane transport of sugars in the myocardium.


Delayed inotropic effects of membrane depolarization in ventricular muscle.


N,N'bis-dichloroacetamide induction of anion permeability in beef heart mitochondria.


Phosphate and substrate transport by isolated heart mitochondria.


Calcium pools in excitation-contraction coupling in the cat heart.


Ouabain sensitivity in the rat myocardium: correlation with a model of subcellular calcium movement.


Relationship among changes in intracellular calcium stores, ultrastructure, and contractility of myocardium.


Calcium metabolism and contractility of isolated cardiac muscle from endotoxin-treated guinea pig.


Effects of starvation on isolated heart performance and mitochondrial calcium sequestering.


Effects of norepinephrine on active K transport and automaticity in cardiac Purkinje fibers.


45Ca2+ accumulation by mitochondria and sarcoplasmic reticulum in chronic potassium depletion cardiomyopathy.


Investigation of the calcium cycle in perfused rat and frog hearts.


Myocardial fiber necrosis due to intracellular Ca overload-a new principle in cardiac pathophysiology.


Isoproterenol myocytolysis and myocardial calcium.


Contractile properties of cardiac muscle.


Roles for calcium and free fatty acids in cardiac function.


Regional differences in contractions of mammalian hearts.


Evidence for two components in frog cardiac mechanical activity.


[Determination and evaluation of regional-cerebral hyper- and hypotension].


Bovine brucellosis in Guinea and West Africa.


Therapeutic experiments and intestinal flora studies in swine dysentery.


Further studies on the presence of Salmonella in chickens and hens in the Netherlands.


Histophysiological response of the adrenal tissue homologues to adrenergic drugs in Heteropneustes fossilis (Bloch).


Insecticides and soil microorganisms. II. Effect of dipterex on nodule formation in broad bean and clover plants under different manurial treatments.


Influence of tetramethyl lead on the proplastids of plant cells.


Effects of gestyl on the ovary of Rana ridibunda pallas.


Activity and electric shock interactions with strain and sex in the rat.


Effect of FSH and LH on the glycogen concentration in testis of intact and hypophysectomized rats.


The organ of Zuckerkandl of the newborn rat and its postnatal involution.


Effects of perinatal testosterone treatment on body weight, open field behavior and Lashley III maze performance of rats.


A study on the stimulus for compensatory renal hypertrophy.


Cell size and body weight in some homoetherms and poikilotherms.


On the stimulation of histamine receptors in heart muscle.


Impulse interference in the summated electromyogram.


Data on the functional organization in the amygdaloid complex obtained on the basis of effects on the blood pressure.


Certain changes in the higher nervous activity of functionally loaded and immobilized 10-month-old albino rats.


Isopycnic centrifugation of 65Cu-loaded mitochondria in a sucrose density gradient.


Uptake of injected copper in liver mitochondria from copper-deficient and copper-loaded rats.


Neuropharmacological activity of new derivatives of 3,3-diethyl-2,4-pyridinedione. II. Communication: 5-aminomethyl derivatives of the 3,3-diethyl-2,4-pyridinedione.


Experimental study of the effect of lithium, haloperidol, caffeine and theophylline on convulsive seizure reactions.


On the mechanisms of changes in the frequency of generation of the slow potential from the stomach upon electric stimulation.


A multicentric evaluation of pimozide (Orap) in patients who usually would take tranquillizers.


The effect of antiinflammatory drugs on the blood coagulation system.


Non-surgical synovectomy. (Basic principles).


Experimental studies on osmic acid and yttrium 90 in synovitis.


Immunological and non-immunological mechanisms of intolerance reactions to aspirin.


Recent progress in the pharmacology of kinins with respect to inflammation.


The mediation of rheumatoid inflammation by lysosomes.


Digestion of autologous IgG by acid lysosomal protease (cathepsin D) and its role in immune complex formation and inflammation.


Immunosuppression in the treatment of rheumatoid arthritis. Basic principles and available substances.


In vitro antibacterial activity of amoxicillin alone and in combination with other antibiotics.


Cefazolin.

Cefazolin.


Antibiotics of choice for clinically important bacteria.


The advantages of combining colposcopy and cytology in the prevention of uterine cervix cancer.


Analog computer study of multiple dose pharmacokinetics of gentamicin.


Histological changes on the chorion at failure of contraceptive intra-uterine devices.


Myocardial revascularization employing non-suture method of internal thoracic-coronary artery anastomosis in experiments on dogs.


Microdrainage of anterior chamber of eye glaucoma operation using hydron capillary drain.


The radiology of parasitic diseases.

The radiology of parasitic diseases.


Cerebral dysfunctions an attempt at clarification.


Prolonged progestin (quingestanol) therapy of menopausal diabetic women. The reduction of high serum LH levels toward or to normal in diabetic women in the menopausal range recorded during the first year of treatment with a synthetic progestin, 17-alpha-ethynyl-19-nortestosterone acetate, 3-cyclopentylenol ether (quingestanol acetate), was maintained during the second and third years of daily ingestion of this steroid. Normal LH and normal or high FSH levels  prior to therapy were not affected. Other endocrine indices, including serum PBI and T4, plasma 11(OH) corticosteroids, serum growth hormone titers, insulin responses to oral glucose, and urinary excretion of 17-ketosteroids, Porter-Silber chromogens, and 11-desoxycortisol metabolites, estrogens, and creatinine remained relatively unchanged during quingestanol therapy. At the 36th month of treatment, a small increase in fasting blood glucose levels with greater hypoglycemia after oral carbohydrate was noted, but this probably reflected the natural history of treated diabetes mellitus. The decrease in urinary steroid responses to partial blockade of adrenal 11-beta hydroxylase by metyrapone observed in the 12th month of quingestanol therapy was not evident at the end of 24 and 36 months of treatment. Quingestanol therapy was associated with maintenance of the increase in serum sodium from low-normal to mid-normal concentrations noted during the first year of treatment. Serum chloride increases were less frequent. Other serum electrolytes, solutes, proteins and other nitrogenous constituents, lipids, and enzymes and formed blood elements generally fluctuated within the pre-therapy ranges. Body weight, blood pressure, pulse rate, electrocardiograms, and perception of vibrations were about the same prior to and at the completion of the three-year course of therapy. The steroid was well tolerated.


EEG spectrum analysis techniques applied to the problem of psi phenomena. Electroencephalographic techniques were used to study unusual sensory capabilities. One S, the "sender," of a pair of Ss was stimulated with 10 sec duration trains of flicker at 6 or 16 fps, randomly interspersed with periods of no flicker. EEGs were recorded from another S, the "receiver," to determine if EEG driving or alpha block would be evident on trials when the sender was stimulated, compared to when the sender was not stimulated. Differential alpha block on control and stimulus trials was observed reliably in one receiver, indicating some information transfer. The S's overt indications of which stimulus occurred were not different from what would be expected by chance. The physical parameters by which the EEG effect was mediated were not determined.


Anesthesiologic considerations in psychiatric convulsive therapy. The authors, drawing from their very large experience, describe technics of administering anesthesia and muscle-relaxing agents for convulsive therapy. After a brief historical review, they mention in detail the materials used and the set up for this modified electroconvulsive treatment. They describe the signs of amnesia and those of muscular relaxation in order to administer a modified electroconvulsive treatment properly. A comparison of this modification  with various other methods used in different centers is made. A section of the paper is devoted to the less common use of Indoklon. Contraindications for the various therapeutic methods are mentioned and a critical evaluation is provided. The authors draw conclusions from their clinical experience and give the results of their observations. The management of various side-effects and possible complications is discussed. The article should be considered as a guide in the use of modified convulsive therapy.


Centration-distortion error: a criterion of perceptual dysfunction. This was a study to determine whether centration, as a perceptual process, could be a criterion for differentiating between neurologically impaired and emotionally disturbed children. Centration was defined by Piaget as a prolonged involuntary attachment of a sensory modality to one part of a field, causing perceptual errors of exaggerations and distortions. It is hypothesized that centration would affect motor behavior, producing effects on drawing tasks characterized by separation of designs or their parts, coincident with distortions of the figures drawn. The neurologically impaired children were identified as having primary difficulties with perception whereas the emotionally disturbed children would have primary difficulties with intellection. The centration-distortion error would characterize the drawing of the neurologically impaired but not those of the emotionally disturbed children. A sample of 44 children was selected, each with EEG records, psychological tests and psychiatric interviews used as differential criteria for the groups. Eleven children were diagnosed as having minimal brain damage, 33 as emotionally disturbed. Three psychologists scored the Bender Gestalt tests, blind, for indicators of brain injury and emotional disturbance as defined by Koppitz' criteria, and for the centration-distortion error. The hypothesis was upheld at the .001 level of confidence, validating an earlier pilot study.


A laboratory investigation of telepathy: the study of a psychic. A series of experiments in psychic phenomena were undertaken with a 21-year-old man who claimed to have telepathic ability. An elaborate procedure was devised to render collusion between Transmitters and Receiver ineffective, if not impossible. Results tended to support the subject's claims. Several single responses are reported which seemed particularly noteworthy with respect to correlation in time and content. A Control subject, duplicating the experimental procedure, did not have the overall success rate demonstrated by the experimental subject. The authors conclude that this experiment strongly suggests the possibility of telepathy, but does not prove it.


Rise in plasma free-norepinephrine during anesthetic induction with ketamine. Mean plasma free-norepinephrine concentration rose significantly (p less than 0.001) during induction of anesthesia with intravenous ketamine (2.0 mg/kg) in 12 patients. In contrast, no change occurred during induction with thiamylal (5.0 mg/kg) in a control group of 8 patients. No significant rise in plasma free-epinephrine concentration occurred in either ketamine or thiamylal groups. These data support the suggestion that increased venous return mediated by the sympathetic nervous system may be responsible for the increased cardiac output and hypertension known to occur during ketamine anesthesia.


The neurologist's use of rating scales, EEG, and tranquilizers in dealing with hysterical symptoms. This article is the result of an effort to help the neurologist deal with the hysterical patient on both a diagnostic and therapeutic level. The conclusion reached is that use of major tranquilizers may be needed to keep hysterical symptomatology under control while diagnostic investigation is proceeding and, if the diagnostic studies are negative,  may be used to help ameliorate symptoms in patients unwilling to see a psychiatrist.


The effect of storage on enzyme activities in tissues. The stability to storage at -20 degrees C of 29 enzymes of rat tissues was measured for periods of up to 100 days. The enzymes could be divided into four groups: (1) those that increased in activity with storage; (2) those that showed transient rises subsequently declining to the original activity or below; (3) those that showed no significant change; (4) those that declined in activity. Details of methods used and of results obtained have been deposited as Supplementary Publication SUP 50038 (19 pages) at the British Library (Lending Division) (formerly the National Lending Library for Science and Technology), Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem.J. (1973), 131, 5.


Cyclic metabolic pathway of a butylated hydroxytoluene by rat liver microsomal fractions. A cyclic metabolic pathway was obtained when 3,5-di-t-butyl-4-hydroxytoluene (BHT) was incubated with a rat liver microsomal preparation. The pathway is as follows: BHT --> 4-hydroperoxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-OOH) --> 4-hydroxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-3(0)OH) --> BHT. This metabolic pathway suggests that antioxidants such as BHT owe their high efficacy, at least in part, to their metabolic regeneration.


Ribonucleic acid labelling and nucleotide pools during compensatory renal hypertrophy. During the first 48h of compensatory renal hypertrophy induced by unilateral nephrectomy, RNA content per cell increased by 20-40%. During this period, rates of RNA synthesis derived from the rates of labelling of UTP and RNA after a single injection of [5-(3)H]uridine showed no change in the rate of RNA synthesis (3.1nmol of UTP incorporated into RNA/min per mg of RNA). ATP and ADP pools were not changed. The rate of RNA synthesis was considerably in excess of the increment of total RNA appearing in the kidneys. With [5-(3)H]uridine as label, only continuous infusion for 24h could produce an increase (60%) in the specific radioactivity of renal rRNA in mice with contralateral nephrectomies. With a single injection of [methyl-(3)H]methionine used to identify methyl groups inserted into newly synthesized rRNA, the specific radioactivity of this rRNA was unchanged 5h after contralateral nephrectomy, increased by 60% at 9-48h, and returned to normal values at 120h. Most RNA synthesized in both nephrectomized and sham-nephrectomized mice has a short half-life. Since total cellular RNA content increases in compensatory hypertrophy despite unchanged rates of rRNA synthesis, the accretion of RNA might involve conservation of ribosomal precursor RNA or a change in rate of degradation of mature rRNA.


Effect of cobalt on the synthesis and degradation of hepatic catalase in vivo. 1. The administration of CoCl(2) to rats caused a decrease in hepatic catalase activity as well as a decrease in the amount of catalase protein as measured by immunological assay. The mitochondrial enzyme decreased progressively over 2 days, whereas the cytosol enzyme decreased over 12h and then remained essentially unchanged for 2 days after a single injection of cobalt. 2. Incorporation of [(14)C]glycine into catalase haem was dramatically decreased by a single injection of cobalt, but that into catalase protein remained essentially unaltered. 3. Incorporation of [(3)H]leucine into liver protein increased in rats in a steady state receiving a daily injection of cobalt, which was in contrast with a marked inhibition observed in 5-amino[(3)H]laevulinate incorporation. 4. The initial rate of [(3)H]leucine incorporation into mitochondrial and cytosol catalase did not alter or was slightly depressed in the cobalt-treated animals, whereas the incorporation of 5-amino[(3)H]laevulinate into mitochondrial and cytosol catalase was conspicuously decreased, indicating that haem synthesis was limiting catalase formation. 5. The degradation rate of catalase protein, as measured by a double-labelling method, was not changed by the cobalt treatment.


Inducibility and some properties of the threonine dehydratase of sheep liver. The threonine dehydratase extracted from sheep liver is in an essentially inactive form, referred to here as the precursor, but can be activated by incubation at high temperature in alkaline solution. A method for purification of the activated enzyme to a state approaching homogeneity has been devised. The activated enzyme catalyses the deamination of serine but rapidly loses activity during the process. The enzyme inactivated by incubation with serine can be reactivated under the same conditions as those described for the precursor, the kinetic parameters being the same in both cases. Individual sheep livers differ widely in their content of threonine dehydratase, and the possible role of dietary factors in this variability has been examined. The average amount of the enzyme in the livers of sheep fed on high-plant-protein diets did not differ significantly from that in livers obtained from slaughterhouses, but was higher than that in livers from animals fed only on grass or normal concentrates. Large increases in enzyme concentration were, however, obtained when sheep were injected intraperitoneally with a protein hydrolysate. The enzyme from the livers of these sheep could be purified by the same technique and to the same specific activity as the enzyme from the livers of control sheep.


Fractionation of the proteins of plant microbodies. 1. Glyoxysomes and peroxisomes have been isolated from dark- and light-grown seedlings of pumpkin (Cucurbita pepo) by sucrose-density-gradient centrifugation. 2. Pumpkin microbodies and castor-bean (Ricinus communis) glyoxysomes may be fractionated, by a combination of osmotic shock and treatment with KCl, into three distinct groups of proteins: readily soluble (matrix enzymes), solubilized in the presence of KCl (membrane-bound enzymes) and relatively insoluble (membrane ;ghost' proteins). 3. Sodium dodecyl sulphate-polyacrylamide-gel electrophoresis of ;ghost' fractions indicated that the membrane proteins were generally of low molecular weight; one gel band (mol.wt. 27000-28000) was common to all three microbodies. 4. Although there were major differences in the soluble protein components of pumpkin glyoxysomes and peroxisomes, electrophoresis of the pumpkin microbody ;ghosts' indicated that the membrane proteins were similar, four main components being common to each class of microbody (monomer molecular weights 42000, 34000, 27000 and 17000).


Studies on the role of calcium ions in the stimulation by adrenaline of amylase release from rat parotid. 1. Mitochondrial and microsomal fractions were prepared from rat parotid glands. Both fractions were able to take up (45)Ca. The mitochondrial (45)Ca-uptake system could be driven by ATP (energy-coupled Ca(2+) uptake) or by ADP+succinate (respiration-coupled Ca(2+) uptake). Energy-coupled Ca(2+) uptake was blocked by oligomycin but not by carbonyl cyanide m-chlorophenylhydrazone; respiration-coupled Ca(2+) uptake was blocked by carbonyl cyanide m-chlorophenylhydrazone but not by oligomycin. Microsomal Ca(2+) uptake was dependent on the presence of ATP; the ATP-dependent Ca(2+) uptake was not affected by oligomycin or carbonyl cyanide m-chlorophenylhydrazone. Ca(2+) uptake by both fractions was inhibited by Ni(2+). 2. Incubation of parotid pieces with adrenaline increased the rate of release of amylase and the uptake of (45)Ca. The adrenaline-stimulated release of amylase was not dependent on the presence of extracellular Ca(2+). 3. The effect of adrenaline on the subcellular distribution of (45)Ca in parotid pieces incubated with (45)Ca was studied. In parotid tissue incubated with (45)Ca, both mitochondrial and microsomal fractions contained (45)Ca. Incubation with adrenaline increased the amount of (45)Ca incorporated into the mitochondrial fraction but not the microsomal fraction. In parotid tissue preloaded with (45)Ca subsequent incubation with adrenaline caused a decrease in the amount of (45)Ca found in both the mitochondrial and microsomal fractions. 4. From these data we conclude that the regulation of the cytosolic Ca(2+) concentration in the parotid may involve both mitochondrial and microsomal Ca(2+)-uptake systems. We suggest that the action of adrenaline on the parotid may be to increase the movement of Ca(2+) to the cytosol by increasing the flux of Ca(2+) across mitochondrial, microsomal and plasma membranes.


Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata. A cell-free system obtained from tissue cultures of Andrographis paniculata produces 2-trans,6-trans-farnesol (trans,trans-farnesol) and 2-cis,6-trans-farnesol (cis,trans-farnesol) (5:1), incorporating 10% of the radioactivity from 3R-[2-(14)C]mevalonate. There is total loss of (3)H from 3RS-[2-(14)C,(4S)-4-(3)H(1)]mevalonate and total retention from the (4R) isomer in both the trans,trans-farnesol and cis,trans-farnesol formed. When 3RS-[2-(14)C,5-(3)H(2)]mevalonate is used as substrate, there is total retention of (3)H in the trans,trans-farnesol, but loss of one-sixth of the (3)H in the cis,trans-farnesol. With (1R)- and (1S)-[4,8,12-(14)C(3),1-(3)H(1)]-trans,trans -farnesol and (1R)- and (1S)-[4,8,12-(14)C(3),1-(3)H(1)]-cis, trans-farnesol as substrates, the label is lost from the (1R)-cis,trans and (1S)-trans,trans isomers but retained in the (1R)-trans,trans and (1S)-cis,trans isomers; this shows that the pro-1S hydrogen is exchanged in the conversion of trans,trans-farnesol into cis,trans-farnesol and the pro-1R hydrogen in the conversion of cis,trans-farnesol into trans,trans-farnesol. (1R)-[1-(3)H(1)]-trans,trans-Farnesol and (1R)-[1-(3)H(1)]-cis,trans-farnesol have been synthesized by asymmetric chemical synthesis and exchanged with liver alcohol dehydrogenase. Both the trans- and the cis-alcohol exchange the pro-1R hydrogen atom.


Pyrimidine derivatives and related compounds. XXIII. Synthesis and pharmacological properties of 9-deazaxanthine derivatives.


Solitary cyst of the pancreas and 'reversible diabetes mellitus'.


[Contraceptive agents and cataract].

[Contraceptive agents and cataract]. 3 cases of cataracts in young women after regular and prolonged use of an oral contraceptive (Stediril, used by 80-90% of the women under such treatment in France) are reported. In 1 case, after thorough examination, the use of contraceptives  was ruled out as a factor causing the cataract.  However, the authors are of the opinion that cataract cases among young women are increasing, and recommend further studies to establish a possible correlation with the use of oral contraceptive. The report is followed by a discussion with a  panel of colleagues, some of whom report similar cases.


[Critical study of electrophysiological and physical explorations before cataract extraction on one eye already operated on for retinal detachment].


Immunoglobulins in tracheo-bronchial secretion with special reference to IgE.


Metabolism of radio-labelled C3: effects of in vivo activation in rabbits.


The mediating effect of anti-rat lymphocytic globulin on the uptake of homologous lymphocytes by rat macrophages.


Modulation of the immune response to transplantation antigens. II. The effects of heterologous antisera on the growth of tumour allografts in mice.


Evidence for circulating immune complexes in sarcoidosis.


Effect of X-irradiation on various functions of murine macrophages.


Immunosuppression in the treatment of inflammatory bowel disease. I. Changes in lymphoid sub-populations in the blood and rectal mucosa following cessation of treatment with azathioprine.


Lymphocyte transformation and production of a human mononuclear leucocyte chemotactic factor in patients with Hodgkin's disease.


The effects of protein malnutrition on macrophage function and the amount and affinity of antibody response.


Polymorph migration stimulator. A new factor produced by hydrocortisone-treated monocytes.


Ultrastructure of cells binding immunoglobulin-coated erythrocytes in rheumatoid arthritis.


Agglutinins against human erythrocytes modified by Newcastle disease virus in Mycoplasma pneumoniae infections.


Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.


Synthetic protein-sugar conjugates as models for the complement-inactivating property of atopic allergens.


Effect of hypoxia on intestional propulsive motility in hibernating toads.


Secretion of IgA into 'antigen-free' isografts of mouse small intestine.


Effects of diphenylhydantoin on cardiac arrhythmias induced by picrotoxin.


Altitudes on pain sensation.

Altitudes on pain sensation.


Depletion of neurohypophysial vasopressin content in rats following hemorrhage.


Relation of vagus nerve to cardiac toxicity of ouabain in different blood pH.


Effect of 2,4-dinitrophenol on transmembrane potentials of chick embryonic heart cells.


Impairment of active avoidance in rats with lateral hypothalamic lesions.


Medical congress in Sri Lanka.

Medical congress in Sri Lanka.


Synthesis of C-homo-B-nor-estrone.

Synthesis of C-homo-B-nor-estrone.


"Menstrual regulation" conference in Hawaii.


Report on working of British abortion law.


Amended Tunisian abortion law.

Amended Tunisian abortion law.


Family planning in India: a crisis of confidence.


How China is achieving the unbelievable.


Circadian timing of methylprednisolone effects in asthmatic boys.


British doctors give the pill its strongest vote of confidence so far.


Menstrual regulation update.

Menstrual regulation update.


Female odors evoke ultrasounds from male mice.


The timing of reproduction in red deer (Cervus elaphus) in relation to altitude.


Reproduction in male Pipistrellus pipistrellus (Mammalia: Chiroptera).


Some observations on the sexual activities of badgers (Meles meles) in Yorkshire in the months December to April.


Thermoperiodic entrainment of arousal from torpor in the little pocket mouse, Perognathus longimembris.


Ageing and assessment of reproductive status of Pipistrelle bats, Pipistrellus pipistrellus.


Reproductive compatibility of voles from separate continents (Mammalia: Clethrionomys).


Reproduction and "march madness" in the brown hare, lepus europaeus.


Comparison of continuation rates in oral contraceptive and I.U.C.D. users.


Present state of legalised abortion in the United Kingdom.


Minisuction: an office abortion procedure.


Menstrual induction: II. Psycho-social aspects.


Suction curettage for 'menstrual regulation' (MR).


Intra-amniotic prostaglandin F2alpha augmented with laminaria for induction of mid-trimester abortion.


Comparisons of two copper-bearing loops (size A), copper T and loop D plain.


Volume and copper concentration of menstrual discharge from women employing copper-7 and other types of contraceptives.


Vasectomy as a contraceptive choice in Latin America.


Menstrual induction: I. Medical aspects.


Legal abortion: influences upon mortality, morbidity and population.


Abortion surveillance in the United States.


Some social and attitudinal factors associated with contraceptive choice among low income black teen-agers after an illegitimate birth.


System and technique for blocking the fallopian tubes.


A review of three years' experience with legalized abortions in New York City (from inception to six months after the Supreme Court decision).


Cyproterone acetate for male hypersexuality.


Metabolism of 4-14C lynestrenol in Thai women. The metabolism of 4-14-carbon lynestrenol was studied in Thai women, and the results were compared with a similar study of European women.  The half-lives of radioactivity in plasma and urine, and the levels of urinary radioactivity found in free, sulphate, and acid-hydrolyzed fractions were similar to those reported in the European study.  The levels of radioactivity observed in enzyme-hydrolyzed urinary extracts were significantly lower among Thai women (p=.01), though the difference was probably due to the use of a different enzyme prepararation.  The chromatographic mobilities of free and enzyme-hydrolyzed urinary extracts were similar for both groups, though the levels for the sulphate fractions were so variable in the Thai group that they defied comparison.  The results indicate that the metabolism of lynestrenol in European and Thai women is similar, and that the observed differences are unlikely to have biological significance.


The effect of spironolactone on plasma levels and excretion of testosterone and oestrogens in the urine in males. (A preliminary report).


Ovarian activity and peripheral plasma levels of oestrogens and progesterone in the lactating sow.


Antibodies to semen diluent and infertility in rabbits.


Non-specific uterine infection and bovine fertility. II. Infection patterns and endometritis before and after service.


A two injection schedule with prostaglandin F2alpha for the regulation of the ovulatory cycle of cattle.


Serum luteinizing hormone levels in cattle under various reproductive states.


Factors affecting the respiration of rabbit sperm measured with an oxygen electrode.


Adolescence and formal operations.

Adolescence and formal operations.


Intellectual performance of octogenarians as a function of education and initial ability.


Effect of thyroxine & insulin on the estradiol induced synthesis of phosvitin.


Structure-activity studies on mammalian tissue lysozymes: Part I. Isolation & characterization of rat kidney nuclear lysozyme.


Studies on the glycosidases of semen: purification & properties of two hexosaminidases of bull seminal plasma.


Photorespiratory metabolism in Eleusine coracana, a C-4 plant.


Transfer of colostral immunoglobulins & tetanus antibodies from the buffalo to neonatal calves.


Effects of post-weaning protein deficiency on lipid composition in different regions of the brain in rats.


Influence of pyridoxine & protein on isoenzymes of l-aspartate: 2-oxoglutarate aminotransferase in rat tissues.


Metabolism of glucose & proteins in alcohol-fed rats.


Effect of flavonoids on the manifestations of experimental osteolathyrism.


Effect of certain flavonoids on the cross-linking of lathyritic collagen.


Metal ion interaction with nucleic acid bases: interaction of magnesium ion with uracil.


Anatomy of the female orgasm: fact and fallacy.


Positron annihilation in some hemeproteins.


Effect of gamma irradiation on fatty acid oxidation in rat liver slices.


Ergasteric hepatitis-laboratory infection by hepatitis virus B.


Environment and carriage of hepatitis B antigen in leprosy.


Sero-epidemiological survey of respiratory syncytial virus infection in Pondicherry area--South India.


Toxoplasmosis in South India--a serological study.


Morphological changes in the liver in hepatic amoebiasis.


Serological survey for syphilis in a family planning clinic.


Mucosal surface injury of jejunal mucosa in patients with giardiasis: an electron microscopic study.


Calculated maximal response and ED50 for acid secretion in control subjects and patients with duodenal ulcer.


Life history of Dermacentor auratus Supino, 1897 (Acarina, Ixodidae).


Interruption of pregnancy in rats by 6-azauridine.


Hepatic bromsulphthalein glutathione conjugating enzyme in amoebic liver abscess.


The effect of calcitonin on disuse osteoporosis in young rats.


Bacteriological study of cases of upper and lower urinary tract infection.


Sensitization response and radiation response in carcinoma cervix.


Reconstruction of the common bile duct with intact serosal onlay patch--an experimental study.


Changes in resistance to hypoxia following single short-term exposures to hypoxia.


Sperm physiology in the female reproductive tract.


A preliminary report on the effect of 'Prajana' on reproductive organs in immature mice.


Studies on biometry of genital organs of female goat.


Growth and puberty in Surti buffalo bulls.


The leptospiral agglutinin of Korean dogs and wild rats by employing filter paper and rapid microsocpic agglutination test.


Leptospirosis in animals and man in the Philppines. VIII. Serological incidence in native dogs.


An investigation of canine leptospiral antibodies in Tokyo and Yokohama. Comparison of Canine Positive rates between rapid microscopic agglutination test and Schüffner-Mochtar test.


A comparative study of primary irritant and allergic contact dermatitis in guinea pigs--macroscopic and histopathologic observations.


Degradation of DNS-gastrin with tissue homogenate.


A study of allergic contact dermatitis in man.--Macroscopic, light and electron microscopic observations--.


Metabolism of synthetic human gastrin and DNS-gastrin in rats and mice.


Light and electron microscopic study of spontaneous flare-up reaction in man.


Atlas of tissue culture; astrocytoma and glioblastoma.


Meckel's diverticulum found at autopsy a feto-pathological study of sixty-one cases.


Kinin-forming factors in acid-heat-treated human serum.


A case of Mycobacterium kansasii infection.


Tolerance of one species of jerboa (Jaculus orientalis) to prolonged exposure to deep hypothermia.


Editorial: Continuing education and practice audit.


Editorial: Teaching the teachers.

Editorial: Teaching the teachers.


The development of vocational training for general practice.


A framework for good primary medical care--the measurement and achievement of quality.


The accreditation of vocational training programmes--results of a pilot survey.


Continuing education in general practice in England and Wales. In 1970, a random sample of 9.5 per cent of general-practitioner principals in England and Wales were asked about continuing education; 53 per cent of them replied. Respondents preferred long intensive courses, thought that dissemination of information about national courses was defective, and the 32 per cent who required a locum before they could attend a course had difficulty in obtaining one. Local educational activity is enhanced by the presence of a postgraduate medical centre.


Survey of general practitioners' views on postgraduate education in North-east Scotland. A questionnaire was sent to all doctors in North-east Scotland enquiring about postgraduate education. The educational programme devised by the Education Committee of the North-east Scotland Faculty of the Royal College of General Practitioners was considered to be relevant, interesting, and well-planned. Suggestions made by the doctors have been taken account of by the Education Committee in their present programme.Journals considered to have the best educational content were Prescriber's Journal, Update and The Practitioner. Those doctors who read The Journal of the Royal College of General Practitioners thought it expressed up-to-date and helpful views about the development of general practice. However, it was ranked poorly alongside such journals as Update.The doctors rated contact with their partners and hospital colleagues as the most important sources of education. These links must be a growth point for postgraduate education within an integrated health service.One-week courses, covering several subjects with a variety of presentations, were most favoured by the replying doctors.


A model contract for trainees in general practice.


The trainee practitioner and the social services department.


A further study of trainee general practitioners.


An appointment system in a teaching practice. Some patients have difficulty in achieving an appointment to see a doctor in a university teaching practice. Only five per cent of patients indicated serious difficulty. Patients who discriminate in favour of seeing a particular doctor have greater difficulty. It is suggested also that some patients have the same difficulty if they are making an appointment to see a particular doctor.Clearly there is a need to explore the problem further to determine the nature of the difficulties which patients experience. It might then be expected that improvements can be made which will help patients to achieve appointments more easily. At the same time it has to be recognised that there may be some patients who will continue to have difficulty in achieving an appointment however much they are helped. Such patients may need access to community health care services in a manner entirely different from the appointment system.Most patients prefer to see their general practitioner by appointment. Both open-access surgeries and appointment systems cause difficulties for patients. The former is associated with the difficulty of long waiting periods and the second with difficulties in achieving an appointment. As some form of appointment system is likely to be continued, particularly for group practices and health centres, it is probably timely to audit patients' experience of achieving appointments.University teaching practices present general practitioners with unusual additional stresses on an appointment system. The full-time teacher's day is divided between service to patients and teaching or research. Any reduction in the availability of a particular doctor in a group may result in patients having difficulty in making an appointment. This argument could equally apply to any group of practitioners who have commitments other than to general medical services.


Patterns of sexual arousal in heterosexual males.


Human rights in relationship to induced abortion.


Marijuana and sexual activity.

Marijuana and sexual activity.


Attitudes of women who have had abortions. In 1970-1971, 205 women in Minnesota who had undergone abortion answered questionnaires to determine their attitudes toward the abortions.  The average age of the respondents was 23, ranging from 14 to 43 years.  39% reported use of some psychic trauma related to the abortion.  6% had had previous abortions.  Women with more education tended to be more liberal in their attitudes toward abortion, while those who were more religious tended to be more conservative.


Marital coital rates, spouses' ages, family size and social class.


Evaluation of the role of primary nurse in an oncology department.


On implications of small group research in group therapy.


The meaning of social and community psychiatry.


A group training programme dealing with the problems of senior staff in custodial institutions.


Immunocompetence in advanced cancer patients prior to chemotherapy.


Suppression of mouse ependymoma growth after immunization with tumor ribosomal complexes.


PO2 distribution in tumor tissue of DS-carcinosarcoma.


Primary malignant melanoma of the vagina.


Psychological characteristics of patients with the irritable bowel syndrome.


The incidence of the shock syndrome in a general hospital.


Abnormal fatty acid composition and human atherosclerosis.


Verapamil in the treatment of paroxysmal supraventricular tachycardia.


Complications of dietary deficiency of vitamin B12 in young Caucasians.


Eosinophilic leukaemia terminating with an encephalopathy.


Megaloblastic anaemia associated with the oral contraceptive pill.


Treatment of pulmonary tuberculosis in a patient on maintenance haemodialysis.


Some clinical pharmacological studies with indoramin, with observations on its therapeutic usefulness.


Pericarditis during chronic haemodialysis therapy.


Haematuria of unknown origin.

Haematuria of unknown origin.


Study of the lipid-lowering action of choloxin and nilevar in patients with chronic renal failure.


Purpura fulminans with haemolytic anaemia.


A case of primary cerebral venous thrombosis.


Rupture of the stomach following mouth-to-mouth respiration.


Subarachnoid haemorrhage in pseudoxanthoma elasticum.


Pollution and mental health, with particular reference to the problem in noise.


The effect of hyperthermia on the secretion of catecholamines, corticosterone and antidiuretic hormone and on the fibrinolytic activity of the plasma.


Cerebral blood volume changes in rats subjected to the action of linear acceleration.


Cytospectrophotometric investigations on bull spermatozoa preserved by freezing.


Circulatory responses to venous air embolism and decompression sickness in dogs.


Suppression of the high pressure nervous syndrome in human deep dives by He-N2-O2.


Alternobaric vertigo and hearing disturbances in connection with diving: an epidemiologic study.


Effects of helium gas on heart rate and oxygen consumption in unanesthetized rats.


Effect of breathing helium on sympathetic nervous and cardiovascular functions.


Functional responses of diaphragm muscle in the rat to varying PCO2 levels and helium content in hyperbaric atmospheres.


Modification of a standard bicycle ergometer for underwater use.


Glucose homeostasis of man in helium-oxygen at 1-50 atmospheres absolute.


Function of the eustachian tubes in divers with a history of alternobaric vertigo.


Performance decrements under hyperbaric He-O2.


Combined effects of elevated pressures of nitrogen and oxygen on operant performance.


Linear polarizing filters and underwater vision.


Restoration of hand function. Rehabilitation of the injured hand.


Interaction between drugs.

Interaction between drugs.


The value of intensive care.

The value of intensive care.


New views of insomnia.

New views of insomnia.


Fitness to drive.

Fitness to drive.


Skin manifestation of visceral disease.

Skin manifestation of visceral disease.


Diabetic retinopathy.

Diabetic retinopathy.


Sperm aging effects on the chromosomal complement in rabbit blastocysts.


Myometrial activity and its exploration by electromyography of uterine smooth muscle.


Some aspects of reproduction in fat-tailed sheep in subtropics. IV. Puberty and sexual maturity.


Clinical experience with the CU-7 intrauterine device in Japan.


Cause of death and prognosis of urinary tract infections and micturition disturbances in patients who had survived 5-years after treatment for cervical cancer.


Oral contraceptives in Japan.

Oral contraceptives in Japan.


Studies on the RNA synthesized in the ovary of immature rats after PMS administration.


Study of the amniotic fluid and maternal serum creatinine in normal and abnormal pregnancies.


Metastatic adenocarcinoma in the uterine cervix. A report of two autopsy cases.


Studies on the relationship between uterine blood pressure and sexual function.


Proliferating Brenner tumor.

Proliferating Brenner tumor.


An immunological factor in the etiology of human ovulatory failure.


Progesterone secretion in perfused utero-tubo-ovarian unit in vitro.


Comparison of analgesia and anesthesia for labor between the university hospitals of the U.S.A. and Japan including our own.


Production of heat-stable alkaline phosphatase by human placenta in tissue culture.


Human ovarian contractility in vitro.

Human ovarian contractility in vitro.


Study of the free amino acid pattern in human cerebrospinal fluid along the cerebrospinal axis. The concentration of the free amino acids in CSF of patients whose pneumoencephalogram was pathological (cerebral atrophy) showed a caudocranial decrease along cerebrospinal axis, while in borderline cases or if pneumoencephalogram was normal, an increase of the amino acid concentration could be observed.


The influence of pulmonary growth and development on paediatric respiratory diseases. The mortality, morbidity and symptomatology of respiratory diseases in infants and children may be partially related to age specific phenomena of structure and function. Such are the comparatively smaller functional residual capacity and respiratory surface area; the difference in growth velocity of alveolar numbers and size; the smaller number of intrapulmonary communications; the larger resistance of the peripheral airways accentuated by fewer muscular elements and larger number of mucous glands in the same; and the smaller elastic recoil pressure of the lung in children as compared to adults. Many factors compensate, partially or totally, for these apparent handicaps, but the influence of growth and development on disease processes can certainly not be disregarded.


Treatment of neonatal abdominal cysts.

Treatment of neonatal abdominal cysts. Intraperitoneal or retroperitoneal cystic structures in the newborn appear with a variable clinical picture and in the case of intra-abdominal cysts, surgery is performed mostly on an emergency basis. In such cases the exact preoperative diagnosis is difficult and is seldom made. With early laparotomy, extensive small bowel resection can usually be avoided. Retroperitoneal lesions are mostly of renal origin; in such cases, preoperative diagnosis is easy, being based on specific examinations. In the year 1973, 5 newborns with an intraperitoneal or retroperitoneal cyst have been treated surgically. In this series, one infant died after resection of 90% of the small bowel.


Study of operated hydrocephalus patients three years after surgery. The development of hydrocephalic children who had been subjected to atrial shunt operation in infancy, has been studied at the age of 3 years. Psychological investigation was carried out in 24 of the 27 surviving cases. Mental development was normal in 14 children while 10 displayed mental retardation, of whom 8 are still suited for schooling. The grave aetiologic factors are considered primarily responsible for retardation. The functional development achievable by successful surgical treatment is discussed.


Frequency of chemical diabetes in the parents of diabetic children. Out of 106 parents of 58 diabetic children 5 had manifest diabetes, 19 chemical diabetes, and 28 were suspected of chemical diabetes. In addition, 17 parents displayed reactive hypoglycaemia. This means that apart from the manifest diabetics, 2/3 of the parents displayed a non-physiological oral glucose tolerance test.


Diabetes insipidus and polycythaemia.

Diabetes insipidus and polycythaemia. The case of a fourteen year-old boy suffering from diabetes insipidus and polycythaemia is reported. The possible mechanisms resulting in the association of the two rare disorders are discussed in detail.


45,X/46,XY/47,XYY mosaicism in a phenotypic female with gonadoblastoma. A case of a phenotypic female patient with 45,X/46,XY/47,XYY mosaicism found in lymphocytes as well as in cell cultures prepared from a gonadoblastoma removed by adnexectomy is reported. The two investigated tissues displayed a different distribution of the three cell lines.


Observations on the electroejaculation in red deer.


Shift of cardiooesophageal-junction mucosa.


Application of mathematical classification methods in medicine.


Endocrine effects on peripheral circulation in rats--effect of adrenalectomy.


Endocrine effects on peripheral circulation in rats: effect of suppression of thyroid gland function and administration of dried thyroid gland.


Blood lymphocyte activation in infectious diseases.


Experimental epidural brain compression.


The chiasmata of axolotls.

The chiasmata of axolotls.


Pulse code modulation telemetry in ski injury research. I. Instrumentation. Measurement problems can be classified into instrumentation, data transmission and recording, and analysis. This paper focuses on the transmission of multichannel, high-volume, high-frequency, high-accuracy data. Boot-ski dynamometer and skier velocity anemometer data provide 13 channels of max. 8-mV signals requiring 8-microvolt resolution or 4.45-Newton dynamometer resolution. The data transmission system features durability, power consumption approx. 10 Watts, weight 4.54 kp, range greater than 3,500 m, frequency response 250 Hz, accuracy 1 per cent, temperature stability, dynamic range plus or minus 2 inches. The transducer signals are ampflified to plus or minus 10 V for the 100-kbps PCM system. Special AC amplifiers, driven by an amplitude-stabilized power oscillator, were designed for elimination of radio frequency interference (RFI), improved stability and high signal/noise. Sixteen words are sequentially sampled at 521/sec-13 data, 2 frame counters, and 1 sync. The ground station consists of the PCM decoder with real-time capability and an analog tape recorder. Data is subsequently buffered and formatted onto digital tape by mini-computer.


Telemetered heart rate responses of the rat during free and learned behavior. To assess the effect of recording on the heart rate and on the behavior of the free moving rat, the electrocardiogram was recorded with the aid of radiotelemetry or through wire leads attached to the animal in different behavioral situations. Adaptation of heart rate both within and across sessions in the home cage and in a novel environment (open-field) was observed in rats bearing a transmitter. No adaptation occurred in rats attached to wire leads. The pattern of heart rate changes appeared to be independent of the mode of recording during passive avoidance behavior and when the rats displayed various motor activities like walking, sniffing, rearing or grooming in the open-field. The heart rate of rats attached to wire leads, however, was always higher. These data indicate that radiotelemetry is preferable to the use of wire connections for recording cardiac activity during behavioral studies in the rat.


A multichannel EEG telemetry system utilizing a PCM subcarrier. A multichannel personal type telemetry system is described that utilizes PCM encoding for the most effective range with minimum RF bandwidth and noise interference. Recent IC developments (COS MOS) make it possible to implement a sophisticated encoding system (PCM) within the low power and size constraints necessary for a personal biotelemetry system. This system includes low level, high impedance preamplifiers to make the system suitable for EEG recording.


Spectral analysis of electroencephalographic recordings of long duration by means of band-pass filters. A method is proposed for spectral analysis of EEG recordings of long duration, using a set of band-pass filters. The sensitivity of the filters varies continuously over their full range, and the input signal is sampled at every sensitivity level. The full spectrum is presented as an array of numbers where the columns are the frequencies and the rows the sensitivity levels, printed as a percentage of the total possible responses of the filter (percent of activity). The logarithm of the numbers expressing the activity of a filter are used for the calculation of the regression line. Thus, the activity in each frequency is characterized by two parameters, the slope and the ordinate at origin, the slope being the more interesting one.


Oxygen monitoring in neonatal medicine.

Oxygen monitoring in neonatal medicine. In perinatal intensive care medicine, hypoxia and hyperoxia are both detrimental to the patient. PO2 measurements of arterial blood can be done in different ways: (1) by analysing blood obtained from an arteriopuncture; (2) by analysing blood obtained from an indwelling arterial (usually umbilical) catheter; (3) by using an indwelling catheter with a built-in O2 electrode; (4) by analysing alveolar air for PO2; (5) by measuring cutaneous arterial PO2 transcutaneously. The common principle of all electrodes mentioned is the polarographic one. It appears that for the clinician, the transcutaneous electrode will become the method of choice in the future because of its non-invasiveness to the patient and because of its capability to provide a continuous PO2 record.


Some remarks on parity violating effects of intramolecular interactions.


Can circularly polarized light be used to obtain chiral compounds of high optical purity?


Experiments on the origin of molecular chirality by parity non-conservation during beta-decay.


The origin of molecular asymmetry through the amplification of "stochastic information" (noise) in bioids, open systems which can exist in several steady states.


Amplification processes for small primary differences in the properties of enantiomers.


Disproportionation of enantiomers by precipitation.


The possibility of spontaneous resolution of enantiomers on a catalyst surface.


The characteristics of the vascular reaction in the terminal sector of the portal venous system following major exereses of the liver.


Cytoangiotopography of the rat anterior hypophysis during experimental immunogenesis.


Is fatty streak an atherosclerotic lesion?


Premelanosome morphogenesis in the mouse retinal pigment epithelium.


Effects of hypergravitational graduated time solicitation on ADH and corticosterone secretion and on plasma fibrinolytic activity.


A pathomorphological study of parathyroid tumors.


Morphogenesis and pathogenesis of chronic lung diseases. VI. Autoradiographic demonstration of antigen persistance in experimental pulmonary granuloma.


Hyperbaric inert gases and the hemoglobin-oxygen equilibrium in red blood cells.


Estimate of maximum expiratory flow based on the equal pressure point concept and Weibel's lung model.


N2, H2, and N2O antagonism of high pressure neurological syndrome in mice.


The antipyretic effects of hyperbaric air and salicylate on rats.


Acoustic telemetry from human divers.

Acoustic telemetry from human divers.


Increase in plasma growth hormone concentration: a new effect of helium breathing.


A review of blood changes associated with compression-decompression: relationship to decompression sickness.


Hyperbaric arthralgia during helium-oxygen dives from 100 to 850 fsw.


Bubble formation in gelatin: implications for prevention of decompression sickness.


Comparison of U.S. Navy air decompression tables by gas-loading analysis.


The probabilistic nature of decompression sickness.


Modification of operant performance in pigeons by increased pressures of nitrogen and helium.


Changes in blood carboxyhemoglobin during simulated saturation diving to 50 ATA.


Modulation of cell proliferation by macrophages: a possible function apart from cytotoxic tumour rejection. The in vitro interaction between activated, non-immune macrophages (AM) and a variety of syngeneic, allogeneic or xenogeneic "normal" and "malignant" target cell lines was followed by different parameters such as target cell proliferation, viability or morphology.Proliferation of all rapidly replicating cell lines examined, irrespective of whether they were of syngeneic, allogeneic or xenogeneic origin, or showed normal or neoplastic growth characteristics, was similarly blocked by the presence of AM in an effector/target cell ratio of 10:1. It was only in very slowly proliferating cells that this inhibitory effect was not detectable. A marked diminution in target cell proliferation was also achieved with target cells growing in suspension, where maintenance of close contact between effectors and targets is unlikely, indicating that this macrophage effect may be mediated by a soluble product of AM.The finding of clear differences in the proliferation inhibition of slowly proliferating normal and neoplastic targets suggested that proliferation per se may not fully mirror the consequences of the macrophage/target cell interaction. This was affirmed when viability and morphology were used as parameters: viability was virtually unaffected in normal targets whereas neoplastic cells were killed.Accordingly, it is suggested that activated non-immune macrophages can affect targets in strikingly different ways. Inhibition of proliferation could be an important homoeostatic regulatory function of the macrophage which would affect every replicating cell. Cytocidal killing of targets, on the other hand, is achieved only on neoplastic cells.


The effect of irradiating a transplanted solid sarcoma on the subsequent development of metastases. A slowly growing solid sarcoma was implanted subcutaneously on the anterior chest wall of mice. On reaching a predetermined size the tumours were locally irradiated using 240 kV x-rays with single doses of 0, 2000 or 5000 rad. The mice were sacrificed 12 weeks after irradiation and examined for lung metastases, which were found to be less frequent in those mice whose implanted tumours had received the most irradiation.


Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice. Single toxic doses of 1,2-dimethylhydrazine induced mild centrilobular necrosis of the liver in rats and mice. Ultrastructural studies showed hepatic nuclear changes including nucleolar microsegregation and changes in the endoplasmic reticulum and mitochondria. 1-Methylhydrazine caused little morphological change in the liver. Tumours of the colon and kidney and also massive cystic hyperplasia of the liver were found in some of the rats and tumours of the anal margin and kidney in some of the mice, following single doses of 1,2-dimethylhydrazine. Incorporation of amino acids into rat liver proteins was inhibited by 1,2-dimethylhydrazine, which also caused disaggregation of hepatic polysomes. No effects on hepatic protein synthesis by 1,1-dimethylhydrazine or 1-methylhydrazine were observed. Similarities between the effects of 1,2-dimethylhydrazine, cycasin and dimethylnitrosamine are discussed.


The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine. 1,2-Dimethylhydrazine, in contrast to 1-methylhydrazine, is a potent carcinogen for the colon in rats and mice. 1,2-[(14)C]Dimethylhydrazine was administered to rats and mice in doses which are carcinogenic following a single dose in the former species, or carcinogenic on repeated administration in the latter species, and the rate of (14)CO(2) exhalation was measured. Exhalation of (14)CO(2) was also studied after administration of single doses of 1-[(14)C]methylhydrazine to mice. Incorporation of radioactivity into the nucleic acids of a variety of organs was found at a time after injection (about 6 h) when (14)CO(2) production from both compounds was virtually complete. Methylation of nucleic acids of liver and colon, as indicated by the formation of 7-methylguanine, was observed after treatment with 1,2-dimethylhydrazine and to a smaller extent by a factor of about 10 after treatment with 1-methylhydrazine. Less than 1% of a single dose of 1,2-[(14)C]dimethylhydrazine was excreted in the bile of rats as determined by chemical and radioactivity assays. The similarities of the biological and biochemical actions of 1,2-dimethylhydrazine with those of some nitroso compounds and of cycasin (methylazoxymethanol glucoside) are emphasized.


On the theory of clonal selection in carcinogenic transformation. A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.


The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.


Carcinogenic action of 5-nitroacenaphthene.


Temperature effects in measurements of respiratory oxygen.


A radio-controlled monitoring system for multichannel telemetry.


Telemetry of the EEG and EMG in the cat under the influence of psychotropic drugs.


Two methods of assessing changes in the deep-body or core temperatures of swimming children and their future application in the field.


Field studies on animals.

Field studies on animals.


Ethical, social and legal dimensions of screening for human genetic disease: Introduction.


Ethical, social and legal dimensions of screening for human genetic disease.


Chromosomal screening of human populations; a bioethical prospectus.


Informed consent in genetic screening programs.


Sociologic studies in human genetics. I. Compliance factors in a voluntary heterozygote screening program.


Some social and psychologic issues in genetic screening. Public and professional adaptation to biomedical innovation.


The practitioner's view of the values involved in genetic screening and counseling. Individual vs. societal imperatives.


Genetic screening and human values: an analysis.


Ethical issues in genetic screening; models of genetic responsibility.


Genetic screening as a political and social development.


Issues of law and public policy in genetic screening.


The mechanism of tolerance in contact hypersensitivity to dinitrochlorobenzene in guinea-pigs.


Inhibition of monocyte spreading. A direct in vitro test for assessing delayed-type hypersensitivity in man.


Boomslang bite with haemorrhage and activation of complement by the alternate pathway.


Superiority of corpuscular BCG to soluble PPD antigen in the leucocyte migration assay.


Studies on the control of antibody synthesis. VI. Effect of antigen dose and time after immunization on antibody affinity and heterogeneity in the mouse.


Enhancement of delayed skin hypersensitivity by neuraminidase in cancer patients.


The effect of anaesthesia on the lymphocyte response to phytohaemagglutinin.


Editorial: Human schistosomiasis (an African health challenge).


Species of schistosomes found in man in Egypt.


Studies on the newly formulated 5,2'-dichloro - 4'-nitrosalicylanilide, "Mollutox".


Some urological aspects of haematobiasis (points of view on pathogenesis).


Effect of sub-lethal doses of molluscicides on the susceptibility of Bulinus truncatus snails to infection with Schistosoma haematobium.


Therapeutic evaluation of hycanthone in school children in rural endemic area in Egypt.


On the synthesis and fate of a new labelled antibilharzial drug (Bilharcid- 124Sb).


In vitro action of progestagens on sperm migration in the human cervical mucus.


Prostaglandin F2alpha: effect on cortisol, growth hormone, luteinizing hormone, follicle-stimulating hormone, prolactin and thyroid-stimulating hormone.


Microbiological transformations of terpenes: Part XXII--Enzymes involved in the degradation of camphene in the Pseudomonas camphene strain.


A constitutive pyridine degrading system in Corynebacterium sp.


Age-dependent induction of arginase in the liver of rats.


Trehalase of Culex pipiens fatigans.

Trehalase of Culex pipiens fatigans.


Multiple forms of aspartate aminotransferase from germinated green gram Phaseolus aureus roxb.


Sedimentation & osmofragility characteristics of rat liver lysosomes--alterations caused by feeding protein-free diet to adult rats.


In vivo activity of nitrate reductase in maize seedlings.


Lipids of Alcaligenes faecalis.

Lipids of Alcaligenes faecalis.


Studies on biosynthesis of liver lipids in threonine-deficient rats.


Biochemical changes in experimentally induced hypercholesterolemia:activity of rabbit hepatic microsomal & mitochondrial enzymes & changes in the lipid composition & enzymic activity of RBC Membrane.


Serum lipid profile in myocardial infarction.


Studies on metabolism in rats with ethionine-induced fatty liver.


Changes in chemical & fatty acid composition during the last phase of maturation of seeds of two Indian mustard cultivars Brassica juncea Coss.


Normal & malignant tissues--an investigation by pulsed nuclear magnetic resonance.


Effect of insecticide Take-20 O, O-dimethyl malathion on hepatic drug metabolism & lipid peroxidation in young growing rats.


Lipid lowering effect of allyl propyl disulphide isolated from Allium cepa Linn. on long term feeding to normal rats.


Pathology of sarcoidosis: perspectives and relevance.


Serum cholesterol: a physician's dilemma.


Levels of serum immunoglobulins in pulmonary tuberculosis patients.


Lung function in tropical eosinophilia.

Lung function in tropical eosinophilia.


Long-acting corticosteroid in obstructive airway disease.


Pulmonary resection in child-bearing age and its effect on pregnancy.


Primary tumors of the thorax in children.


Clinical study of pulmonary suppuration.


Hydatid disease of the lung.

Hydatid disease of the lung.


Study of broncho-pulmonary suppurative diseases with special reference to bacteriology.


Meniere's disease and allergy, with special reference to immunoglobulin E and IgE antibody (reagin) in serum.


Association of pulmonary tuberculosis and cryptococcosis.


Caloric prestimulation alerting nystagmus.


Epidural drainage operation for Meniere's disease.


Minor elements and evolution.

Minor elements and evolution.


Optimal design of feedback control by inhibition.


Hot hydrogen atoms reactions of interest in molecular evolution and interstellar chemistry.


New reactions of paraformaldehyde and formaldehyde with inorganic compounds.


Letter to the editor: A re-examination of the zeolite-promoted, clay-mediated peptide synthesis.


Letter to the editor: Analysis of heterozygosity in regard to the neutrality theory of protein polymorphism.


Treatment of urinary bladder paralysis with small calibre suprapubic drainage.


The neuropathic bladder in childhood: urinary diversion or conservative treatment?


Bladder neck resection in multiple sclerosis. Surgical aspects.


Sexual disturbances after brain injury.

Sexual disturbances after brain injury.


Use of the diaphragm with sperimcidal agent.


Common errors patients make with diaphragms and foams.


Factors affecting coital frequency.

Factors affecting coital frequency.


The healer, the community or the bureaucrat.


Sexual adjustment to contraception: oral contraceptives versus tubal ligation.


Social psychiatry in western Europe.

Social psychiatry in western Europe.


Theatre, communication and mental health.


Crisis intervention in groups: some underlying considerations.


Israel's community workers in the aftermath of war.


The rights of the mentally ill. Towards a review of the concept of psychiatry and the psychiatrist.


Diagnosis and therapy of families of patients on chronic hemodialysis.


Suicide attempts in Thessaloniki area. Clinical and psychopathological findings of the first year of research.


Letter: Radical notion.

Letter: Radical notion.


Letter: The paraprofessional.

Letter: The paraprofessional.


The diagnosis and understanding of schizophrenia. Part I. Use of signs and symptoms for the identification of schizophrenic patients.


The diagnosis and understanding of schizophrenia. Part III. Speculations on the processes that underlie schizophrenic symptoms and signs.


Hospitals, patients, and politics.

Hospitals, patients, and politics.


Financial management. An overview.

Financial management. An overview.


"That the child may rise in the world:" a folk belief and custom of the nursery.


Preparation and analysis of structural proteins of the small ribosomal subunit of rat liver.


Circular dichroism studies on proteins and 18S-RNA of rat liver ribosomes.


Studies on proteins of animal ribosomes. XIX. Electrophoretic and immunological analysis of ribosomal proteins of different species of vertebrates.


Binding of aminoacyl tRNA to ribosomes: a function of 5S-RNA.


The biological function of the TpPsipCpGp loop (loop IV) of tRNAs in various ribosome-dependent reactions.


Affinity labeling of ribosomes.

Affinity labeling of ribosomes.


Studies on proteins of animal ribosomes. XX. Iodination of rat liver ribosomal proteins.


Enzymatic phosphorylation of eukaryotic ribosomal proteins and factors of protein biosynthesis.


Enzymic iodination of ribosomal subunits from rat liver.


Studies on proteins of animal ribosomes. XXI. Tryptic digestion of rat liver ribosomal particles.


Studies on proteins of animal ribosomes. XXII. Localization and function of ribosomal proteins studied by chemical substitution with iodoacetamide and methyl-acetimidate.


Ion binding and ribosomal conformation and function. Experiments with the K+ analogue, T1+.


Electron microscopic studies of the substructure of eukaryotic ribosomal RNA.


On the electronmicroscopic structure of mRNA and pre-mRNA from rabbit reticulocytes and bone-marrow cells.


Comments on the electron microscopical structure of rabbit reticulocyte ribosomal particles.


Electron microscopic studies on the structure and dissociation of rat liver ribosomes.


Studies on the structure of animal ribosomes. V. Studies on the size and structure of rat liver ribosomes by small angle X-ray scattering.


The activity of cytosolic fraction and ribosomes of different tissues in cell-free protein synthesis.


Regulation of protein biosynthesis in eukaryotes. III. Activity of cytosolic subfractions from liver and kidney of the rat in cell free polysomal systems.


Influence of cytoplasmic factors on protein synthesis in rat liver.


Influence of phenobarbitone on the size and activity for protein synthesis of liver polyribosomes from fasted rats.


Inhibition of the EF-Tu factor by L-1-tosylamido-2-phenylethyl chloromethyl ketone.


A contribution to the studies on donor site of peptidyl transferase with acylaminoacyl-nucleoside-5'-monophosphates.


Regulatory elements in initiation of phage f2 RNA translation.


Purification and some properties of peptide initiation factors from rat liver.


Presence of a new RNA species among the initiation protein factors active in eukaryotes translation.


Properties of elongation factor 1 from ascites tumor cells.


Protein synthesis in well-defined subcellular systems from rat liver directed by natural mRNAs.


Ribosomes and biosynthesis of proteins. Concluding remarks.


Some aspects of the biosynthesis of ribosomal structural proteins in regenerating rat liver.


Influence of retinal shielding pigments on light sensitivity in the crayfish.


Sperm penetration through the zona pellucida of immature hamster oocytes.


The anatomy, histology and biogenic compounds of the carotid body of the pig (Sus scrofa).


Letters: Lack of effect of rat milk on intestinal lactase activity in the postweaning rat.


Effect of chronic hypobaric hypoxia on ubiquinone levels in heart muscle.


Electrophoretic heterogeneity of rat erythropoietin.


Effects of d- and 1- propranolol on spontaneous motility and retention in male mice.


Differential diagnosis of pachydermoperiostosis.


The importance of permanent psychiatric consulting in the dermatological clinic.


Frequency of contact allergy in Belgium.


Factitious affections in dermatology.

Factitious affections in dermatology.


Inhibition of spermatogenesis in gerbil (Meriones hurrianae) hedgehog (Hemiechinus auritus collaris) and mice after methallibure (ICI 33828) treatment. The effect of methallibure (ICI 33828) on spermatogenesis was studied in the gerbil, hedgehog, and mouse.  Injection of ICI 33828, at a dose of 100 mg/kg for 10-25 days, caused testicular lesions in the gerbil and hedgehog, and spermatogonia were absent in the seminiferous e pithelium.  Distinct hypertrophy of the Leydig cells was evident.  Acces sory sex gland activity was suppressed.  It is possible that ICI 33828 impairs testicular androgen production and luteinizing hormone (LH) activity, as suggested by reduced seminal veisicle weight and reduced concentrations of DNA and RNA.  Levels of follicle stimulating hormone and LH were considerably reduced.  Both adult male gerbils and hedgehogs were rendered sterile by ICI 33828 at the dose studied, while mice were relatively unaffected.


The effect of vinblastine sulfate on rat spermatogenesis.


Alkali resistance test. A clinical and experimental study.


Tuberculosis cutis ulcerosa.

Tuberculosis cutis ulcerosa.


Resting metabolic rate in pangolins (Pholidota) and squirrels of the equatorial rain forest.


Cardiopulmonary resuscitation: basic life support.


Germinal centre proliferation in response to mitogenic lymphokines.


Diet in gastrointestinal disease.

Diet in gastrointestinal disease.


Penicillamine for systemic sclerosis?

Penicillamine for systemic sclerosis?


Daunorubicin-DNA: further clinical trials in acute non-lymphoblastic leukemia.


A kinetic analysis of death and survival in HeLa cells following exposure to methylazoxymethanol acetate.


An in vitro method for assaying sensitivity to 2,4-dinitrochlorobenzene (DNCB) in man.


Radio-immunoassay of casein in the serum of normal subjects and of patients with various malignancies.


Suppression of mitogen responses by serum from tumour-bearing mice.


Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice.


The influence of a glucocorticoid on the lodgement and development in the lungs of intravenously injected tumour cells.


Increased growth-inhibiting effect on tumour cells of protamine after polymerization.


An improved method for cytogenetic studies of solid murine tumors.


Cerebrospinal fluid otorrhea due to undifferentiated malignant mesenchymal cell tumor of the middle ear region: a case report.


Effects of age and body position on argon closing volume.


An unusual complication of the subcutaneous pacemaker, gas accumulation in the skin pocket.


The action of cholesterol:oxygen oxidoreductase on cholest-5-ene-3beta, 7alpha-diol and the enzymatic preparation of the labeled cholest-4-en-7alpha-ol-3-one.


Sliding hiatus hernia with reflux oesophagitis in two dogs.


Pyloric and oesophageal dysfunction in the cat.


Observations on the effect of age on the severity of heart valve lesions in the dog.


The distribution of spirochaetes in the gingival crevice of a Beagle dog.


Gas gangrene in the dog.

Gas gangrene in the dog.


Loss of libido in men.

Loss of libido in men.


When a patient requests vasectomy.

When a patient requests vasectomy.


Palindromic base sequences and replication of eukaryote chromosome ends.


Concentrating solutes with membranes containing carriers.


How sea snakes may avoid the bends.

How sea snakes may avoid the bends.


Effect of vasopressin on the isolated human collecting duct.


Y chromosome effect on adult testis size.


Development and genetic analysis of bithorax phenocopies in Drosophila.


Plasma binding of vitamin B6 compounds.

Plasma binding of vitamin B6 compounds.


The effect of environmental lighting on porphyrin metabolism in the rat.


Identification of a population of mouse leukocytes using wheat germ agglutinin.


Polyunsaturated fatty acids and colon cancer.


Influence of ethanol, caffeine and intragastric cooling on gastrin and insulin secretion in man.


The absence of undesirable changes during consumption of the low carbohydrate diet.


Subarachnoid haemorrhage in children.

Subarachnoid haemorrhage in children.


Pituitary fossa demineralization in normal subjects.


The Aicardi syndrome.

The Aicardi syndrome.


Neurophysiological mechanism of acupuncture analgesia.


Long segment stenotic lesions of cervical arteries in cerebrovascular disease.


Subacute sclerosing panencephalitis: a study of 25 patients.


Genetic counselling in neuromuscular diseases in Western Australia.


A new myopathy with type II muscle fibre hypoplasia.


A neurophysiological analysis of paramyotonia congenita.


Chuckling and glugging seizures at night -- sylvian spike epilepsy.


Selective vulnerability of the hippocampus to hypoxia: cytophotometric studies of enzyme activity in single neurones.


Palatal myoclonus and associated movements.


Preliminary observations on the clinical pharmacology of carbamazepine ('Tegretol').


Epilepsy and the frontal lobe.

Epilepsy and the frontal lobe.


Visual hallucinations as a symptom of right parieto-occipital lesions.


Social problems confronting a person with epilepsy in modern society.


Temporal lobectomy for epilepsy -- a follow-up.


Cardio-vascular responses to prolonged head-up tilting in tetraplegic man.


Cardio-vascular responses to infused noradrenaline in tetraplegic man.


Cortical blindness with anosognosia subsequent simultaneous agnosia and persistent gross recent memory defect.


Headaches occurring during sexual intercourse.


The Landry-Guillain-Barré syndrome: a clinical and electrophysiological follow-up study.


Colchicine and the peripheral nerve.

Colchicine and the peripheral nerve.


Sensory function of the median nerve: preliminary studies using microelectrode techniques in man.


Hypothesis: A biological model of schizophrenia.


Carbonate ion-selective membrane electrode. A liquid membrane electrode has been developed with Nernstian response and a high selectivity for carbonate ion. The electrode responds rapidly to carbonate in the 10(-2)M to 10(-6)M range with a selectivity for carbonate over chloride, sulfate, and phosphate of at least 10(3) and negligible bicarbonate response. The electrode properties appear to be suited to chemical, biological, chemical, and oceanographic measurements.


Nuclear magnetic resonance studies and water "ordering" in the crystalline lens. Nuclear magnetic resonance studies of the relaxation times of the water in the crystalline lens show that, as in all interfacial systems, these parameters are markedly reduced from their values in pure water, that T(2) is less than T(1), and that both depend on water content. Determination of diffusion coefficients and studies on physiologically inert lenses indicate that reduced relaxation times do not provide direct evidence for ordering of the bulk of the cell water.


Nicotine inhibition of the metabolism of 3,4-benzopyrene, a carcinogen in tobacco smoke. A decreased rate of biliary excretion of radioactive metabolites of 3,4-benzopyrene was observed in rats given a single dose of nicotine. Prior treatment of rats with nicotine decreased benzopyrene hydroxylase activity in homogenates of liver, lung, and small intestine. The addition of nicotine to incubated tissues also decreased benzopyrene hydroxylase activity. These findings show that nicotine inhibits the metabolism of 3,4-benzopyrene in vivo and in vitro.


Banded marker chromosomes as indicators of intraspecies cellular contamination. Chromosome banding revealed marked chromosomes characteristic of HeLa cells in cultures designated HEK, HEK/HRV, HBT-3, HBT-39B, MA160, and a strain of SA-4TxS-Husa(1). Ohter HeLa cell characteristics found were glucose-6-phosphate dehydrogense type A mobility and lack the Y chromosome. Conventional chromosome analysis and immunological and enzymatic technique serve to monitor species specificity and racial origin of the donor. Chromosome banding, however, can monitor intralinear karyotype peculiarity and its evolution during long-term cultivation.


The salt loading provocative glycerol test for the early diagnosis of auditory endolymphatic hydrops (Ménière's disease)  (a preliminary report).


Letter: Energy cost of animal locomotion.


Acupunctural analgesia? Evaluation by signal detection theory. Pain responses to noxious thermal stimulation decreased in the acupunctured arm of subjects as compared to the arm not treated with acupuncture; this result suggested that effective analgesia had been induced. However, sensory decision theory analysis of the data revealed no difference in discriminability. This failure to find a sensory (physiological) change strongly suggests that analgesia had not been induced. The sole effect of acupuncture was to cause the subjects to raise their pain criterion in response to the expectation that acture works.


Abortion, illegitimacy, and the American birth rate. In sum, it appears that legal abortion depressed overall fertility, but particularly illegitimate fertility, by giving women an opportunity to terminate their pregnancies when other means of birth control either had not been used or had failed. If legalized abortion had not been available, an estimated additional 39,000 illegitimate babies and 28,000 legitimate babies would have been born in 1971 in the United States. While this makes up a small part of total births (3,500,000), the illegitimate births prevented represent almost onetenth of all out-of-wedlock children born in the country in that year. In addition to preventing these births the legalization of abortion appears to have reduced the incidence of pregnancy-related marriages and thereby may have helped to limit subsequent marital disruption. Finally, legal abortion prevented large numbers of illegal abortions from occurring. Our data indicate that well over half-most likely between two-thirds and three-fourths-of all legal abortions in the United States in 1971 were replacements for illegal abortions. Further declines in illegitimate birth rates for the country as a whole will depend, in considerable part, on the extent to which legal abortion becomes more readily available and more widely used. Theoretically, greater use of efficient contraception could also cause illegitimate fertility to decline. But there are many reasons why women do not use efficient contraception even when they know about it and have access to the materials (25). Even though the use of abortion throughout the nation is now legalized by the Supreme Court decision, this does not necessarily mean that services will in fact be everywhere more readily available. Our interstate analysis suggests that should the liberalization of abortion laws be reversed, not only would there be an upturn in illegal abortions and pregnancy-related marriages, but also a marked rise in illegitimacy, particularly among women who do not have the means to obtain an illegal abortion.


Peer review: quality control of applied social research.


Acetylcholine noise: analysis after chemical modification of receptor. The elementary voltage pulses ("shot effects") produced by the action of acetylcholine molecules on the receptor were studied by analyzing the membrane voltage fluctuations ("noise") after acetylcholine application at the frog neuromuscular junction. The amplitude of these pulses was decreased after treatment with a disulfide-bond reducing agent. The shot effect may thus depend on the structure or conformation of the receptor molecule.


Hemoglobin switching in sheep and goats: occurrence of hemoglobins A and C in the same red cell. Sheep and goats switch from the synthesis of hemoglobin A (alpha(2)beta(2)(A)) to hemoglobin C (alpha(2)beta(2)(C)) when made anemic. We have demonstrated the existence of the asymmetrical hybrid hemoglobin, alpha(2)beta(A)beta(C), in the circulating red cells of anemic sheep. These erythroid cells, therefore, synthesized both A and C hemoglobin simultaneously. Thus, the switch appears to be mediated by selective gene expression rather than by a clonal or cellular selective mechanism.


Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Weight loss causes loss of menstrual function (amenorrhea) and weight gain restores menstrual cycles. A minimal weight for height necessary for the onset of or the restoration of menstrual cycles in cases of primary or secondary amenorrhea due to undernutrition is indicated by an index of fatness of normal girls at menarche and at age 18 years, respectively. Amenorrheic patients of ages 16 years and over resume menstrual cycles after weight gain at a heavier weight for a particular height than is found at menarche. Girls become relatively and absolutely fatter from menarche to age 18 years. The data suggest that a minimum level of stored, easily mobilized energy is necessary for ovulation and menstrual cycles in the human female.


Isolated brain microvessels: a purified, metabolically active preparation from bovine cerebral cortex. A purified, metabolically active preparation of brain microvessels was isolated from bovine cerebral cortex by using a simple procedure involving mild disruption of the tissue by homogenization and trapping of the vessels on nylon sieves. This preparation permits in vitro metabolic and structural studies of small blood vessels.


Barley stripe mosaic virions assoicated with spindle microtubules. Virions of barley stripe mosaic virus were observed attached to microtubules of the spindle apparatus. This phenomenon was found in barley cells undergoing meiosis and mitosis. The microtubules may be involved in the assembly and cell-to-cell transfer of the virus.


Mitogenic activity of sterculic acid, a cyclopropenoid fatty acid. Hepatocytes in rainbow trout and rat are stimulated to augmented DNA synthesis and cell division by low concentrations of cyclopropenoid fatty acids in the diet. Sterculic acid isolated as the methyl ester from Sterculia foetida oil has been identified as one of the mitogenic principles.


Letter: Sex-associated antigens in mice and rats.


Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor? The effects on insulin secretion of alpha and beta anomers of D-glucose were studied in the in vitro perfused rat pancreas. Both phases of insulin release showed consistent stereospecificity for alpha-glucose; this specificity indicates an action of glucose independent of intracellular glucose metabolism.


Pulsatile growth hormone secretion: suppression by hypothalamic ventromedial lesions and by long-acting somatostatin. Sequential blood samples, obtained from freely behaving, nonstressed male rats, showed a pulsatile pattern of growth hormone secretion with a mean interval between peaks of 68 minutes. The bursts of secretion were blocked by lesions of the hypothalamic ventromedial nuclei and by administration of a longacting preparation of synthetic somatostatin.


Studies of squeezing: handedness, responding hand, response force, and asymmetry of readiness potential. Eleven subjects squeezed an electronic dynamometer, at each of three force levels, with both their right and left hands. In right-handed subjects the premovement "readiness" potentials were larger over the hemisphere contralateral to the responding hand. Left-handed subjects show contralateral dominance when responding with the right hand but not when responding with the left hand. The data suggest that in the potentials studied there is a component associated with the preparation to perform a specific movement, rather than with generalized preparatory processes.


Circadian oscillations in rodents: a systematic increase of their frequency with age. The circadian activity rhythms of golden hamsters and two species of deermouse, when released from a light-dark cycle of 12 hours light and 12 hours of darkness into constant darkness, had progressively shorter periods as the animals became older. A possible bearing of this fact on the aging process is briefly outlined.


Blood velocity measurements in human retinal vessels. Laser Doppler velocimetry was used to measure the velocity of blood in human retinal vessels. The mean flow velocities obtained were 1.9 centimeters per second in a retinal vein and 2.2 centimeters per second in a retinal artery. Scattered light from a weak helium-neon laser beam focused on the vessel was detected by a photomultiplier, and the temporal correlation of the intensity fluctuations was measured with a photon counting autocorrelator. Autocorrelation functions for blood flowing through glass capillaries were used for calibration.