The release of LH at oestrus in ewes on two planes of nutrition during lactation.


An evaluation of the vaginal smear technique for detecting the occurrence of ovulation in the ewe.


Social environment and ovulation in the vole, Microtus agrestis.


Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S-tubercidinylhomocysteine.


Synthesis of 6-(phenylhydrazino)uracils and their inhibition of a replication-specific deoxyribonucleic acid polymerase.


Improved synthesis and additional pharmacology of the potent analgetic (-)-5-m-hydroxyphenyl-2-methylmorphan.


Enzyme inhibitors. Inhibition of brain choline acetyltransferase by derivatives of 4-styrylpyrimidine.


Viral DNA in transformed cells. I. A study of the sequences of adenovirus 2 DNA in a line of transformed rat cells using specific fragments of the viral genome.


Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence.


Arrangement of the 5-8 S RNA cistrons in the genome of Xenopus laevis.


Binding of carcinoembryonic antigen (CEA) to concanavalin A-sepharose: storage of high-specific-activity 125I-CEA.


Solid-phase radioimmunoelectrophoresis: an assay for carcinoembryonic antigen.


Shift of organotropy of azoxy compounds--replacement of methyl with an octyl group.


Radiolabeled antitumor antibodies. III. Highly iodinated and highly radioiodinated antibodies.


Effects of stress on growth of transplanted and 7,12-dimethylbenz(alpha)anthracene-induced tumors and their modification by psychotropic drugs.


Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles.


Chemical carcinogen-induced alveolar nodules in organ culture of mouse mammary gland.


Discrimination between neoplastic and non-neoplastic cells in vitro by activated macrophages.


Is aberrant nucleic acid methylation related to malignant transformation?


Time course of synthesis and assembly of influenza virus proteins. The synthesis of viral polypeptides was analyzed in BHK-21-F cells infected with the WSN strain of influenza virus at various times in the growth cycle. The relative amounts of polypeptides P, HA, NP, and NS did not change markedly between early and late times in the growth cycle; however, there was a progressive increase in the relative amount of the M polypeptide at later time points. In cell fractionation experiments, the patterns of newly synthesized polypeptides associated with various cytoplasmic fractions remained similar throughout the growth cycle except for an increase in polypeptide M in all fractions late in the growth cycle. The HA polypeptide was chased out of cytoplasmic membranes completely 6 h after synthesis, whereas the M polypeptide was not chased effectively from such membranes. Marked differences were found in the incorporation into mature virions of polypeptides synthesized at different times in the growth cycle. Polypeptides P and NP synthesized at early times were incorporated preferentially, whereas M was synthesized and incorporated predominantly late in the growth cycle. The fact that the rates of incorporation of polypeptides into virions differed significantly from their rates of synthesis indicates that different polypeptides were assembled into virions by distinct pathways.


Homologous interference induced by Sindbis virus. Homologous interference during Sindbis virus infection has been investigated. Prior infection of either chicken embryo fibroblast or BHK(21) cell cultures results in reduced yields of progeny virions of the superinfecting genotype. This reduction in yield results from a reduction in the number of cells in the cultures capable of producing the superinfecting genotype. The development of interference parallels the attachment kinetics of Sindbis virus. Interference requires an active viral genome since the activity is sensitive to inactivation by ultraviolet light, and an RNA(-) mutant, ts-24, fails to induce interference under nonpermissive conditions. However, ts-6, an RNA(-) mutant belonging to a different complementation group, and the RNA(+) mutants, ts-2 and ts-20, interfere at both permissive and nonpermissive temperatures.


Defective interfering passages of Sindbis virus: nature of the intracellular defective viral RNA. BHK cells infected with defective-interfering passages of Sindbis virus accumulate a species of RNA (20S) that is about half the molecular weight of the major viral mRNA (26S). We have performed competitive hybridization experiments with these species of RNA and have established that 20S RNA contains approximately 50% of the nucleotide sequences present in 26S RNA. Our further studies, however, demonstrate that 20S RNA is unable to carry out the messenger function of 26S RNA. We found very little of the defective RNA associated with polysomes in vivo. In addition, it was unable to stimulate protein synthesis in vitro under conditions in which 26S RNA was translated. We have also examined viral RNA synthesis in BHK cells infected with standard or defective-interfering passages of Sindbis virus. This comparison suggests that defective partioles do not synthesize a functional replicase.


Inhibition of glycosylation of the influenza virus hemagglutinin. d-Glucosamine and 2-deoxy-d-glucose interfere with the biosynthesis of the hemagglutinin glycoproteins. With increasing inhibitor concentrations a progressive decrease in size of the precursor HA and the cleavage products, HA(1) and HA(2) can be observed. The shift in molecular weight is paralleled by a decrease of the carbohydrate content. This was shown by labeling studies with radioactive sugars which revealed that the inhibitors block the incorporation into glycoproteins, whereas they have no or only slight effects on the uptake and activation of sugars. Under conditions of maximal inhibition, the hemagglutinin proteins lack all or most of their carbohydrates. These findings indicate that the inhibitory effect of d-glucosamine and 2-deoxy-d-glucose is due to an impairment of glycosylation. When glycosylation is inhibited, the precursor polypeptide is synthesized at normal rates. Its cleavage products, however, are very heterogeneous. This suggests that carbohydrate protects the hemagglutinin from proteolytic degradation.


Marek's disease herpesvirus-induced DNA polymerase. Infection of duck embryo fibroblasts by Marek's disease herpesvirus (MDHV), strain GA, led to the induction of a novel DNA polymerase. This novel DNA polymerase, designated MDHV-induced DNA polymerase, could be distinguished from the DNA polymerase activities of uninfected duck embryo fibroblasts by its chromatographic behavior on phosphocellulose, by its sedimentation coefficient, and by its catalytic properties. The characteristics of MDHV-induced DNA polymerase which had been purified by phosphocellulose chromatography were investigated. The sedimentation coefficient of the enzyme, as determined by sucrose density gradient centrifugation in the presence of 0.25 M KCl, was 5.9S. From this sedimentation coefficient, the molecular weight of MDHV-induced DNA polymerase was estimated to be 100,000. MDHV-induced DNA polymerase could not effectively use either poly(dA).oligo(dT)(12-18) or poly(dC).oligo(dG)(12-18) as a template-primer. The DNA polymerases from uninfected duck embryo fibroblasts could use these synthetic template-primers. MDHV-induced DNA polymerase also could not use poly(rA).oligo(dT)(12-18) or poly(rC).oligo(dG)(12-18) as template-primers or oligo(dT)(12-18) as a primer, indicating that it was not a polymerase of the type R-DNA polymerase, reverse transcriptase, or a terminal nucleotidyl transferase. In vitro synthesis of DNA by MDHV-induced DNA polymerase was markedly inhibited by the addition of (NH(4))(2)SO(4) to the reaction mixture.


Susceptibility of Mycoplasma pneumoniae to antibiotics in vitro.


Distribution of leucogenenol in organs, glands and tissues of animals.


The studies of cellular immunity to gynecologic tumors with macrophage migration inhibition test.


Quantitative changes in some unsaponifiable components of soya bean oil due to refining.


Determination of the fat content of meat using nuclear magnetic resonance.


The pathologist and Professional Standards Review Organization (PSRO) or "hauling coals to Newcastle?".


Unusual composition of sterols in a phytophagous insect, Mexican bean beetle reared on soybean plants.


Letter: The economy, social integration and utilization of health services.


The way we live now. Forty-first Sir Richard Stawell oration, 1st May, 1974.


Epidemic polyarthritis in South Australia: report of an outbreak in 1971.


The free clinic movement in the United States.


Effects of products of the reaction of formaldehyde and amino acids on nucleotides and DNA.


Studies on the active center of pancreatic amylase. II. Small angle x-ray scattering investigations.


Isolation of oligonucleotide fragments containing the 5'-ends of nuclear pre-mRNA of Ehrlich carcinoma cells.


Immunoglobulin synthesis by free polysomes of mouse myeloma cells.


Histone-histone proximity in chromatin as seen by imidoester cross-linking.


Binding of netropsin to DNA and synthetic polynucleotides.


Translation of immunoglobulin mRNAs in a wheat germ cell-free system.


Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation of different stages of the cell cycle: the necessity for cells to pass through S.


The keratinophilic fungi of Ontario, Canada.


Inducing sporulation in Alternaria solani. II. Effect of light.


Fungi in the sputum of normal men.

Fungi in the sputum of normal men.


Ventricular systolic septal thickening and excursion in idiopathic hypertrophic subaortic stenosis.


Maternal behaviour and the effects of stress in tree shrews.


Regions of the freezing curve causing changes in structure and viability of ram sperm.


Oxygen microenvironment and respiratory oscillations in cultured mammalian cells.


Developmentally regulated cell surface alterations in Dictyostelium discoideum.


Meiosis in Dictyostelium mucoroides.

Meiosis in Dictyostelium mucoroides.


Reversibility of morphine tolerance and dependence in guinea pig brain and myenteric plexus.


Newly synthesised lipids incorporated into influenza virus membranes.


Hepatitis B and serum DNA polymerase activities in chimpanzees.


Size and location of the transforming region in human adenovirus type 5 DNA.


Is calcium ionophore a universal activator for unfertilised eggs?


Erythropoiesis in a cell population from the early chick blastodisc induced by diffusible product of second cell population.


Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide.


Sequence analysis of immunoglobulin light chain messenger RNA.


Early simultaneous appearance of antigen binding cells in the foetal sheep.


Leukocyte function in normal and infected neonates.


Letter: Rachitic-like osseous changes in CID with absence of erythrocyte adenosine deaminase.


Marijuana metabolites measured by a radioimmune technique.


Local therapy of malignant pleural effusions.


Plasma prolactin levels and hypothalamic catecholamine synthesis during suckling.


Effects of neonatally-administered DDT homologs on reproductive function in male and female rats.


A paradoxical inhibiting effect of ether on prolactin release in the rat: comparison with effect of ether on LH and FSH.


Comparison of the effects of the intranigral injections of cholinomimetics with systemic injections of the dopamine receptor stimulating and blocking agents in the rabbit.


Industry's nurses and collective bargaining: a statement by the American Association of Industrial Nurses, Inc.


Work, society, and health. New opportunities for service and education.


Treatment of central serous retinopathy. A comparative study with and without light coagulation.


Experimental venous occlusion.

Experimental venous occlusion.


Personality and premenstrual tension.

Personality and premenstrual tension.


Control of human ovulation, fertilization and implantation.


Ketamine catalepsy and anesthesia in dogs pretreated with antiserotonergic or antidopaminergic neuroleptics or with anticholinergic agents.


Oxazepam, prazepam, and aggression in mice.


The kinetics of physical dependence to morphine in the rat.


Effects of capture procedures on emotionality scores in rats with septal lesions.


Sensory control of shock-elicited fighting in rats.


Delayed development of amnestic behavior after hypoxia.


Testosterone induced pup-killing behavior in the ovariectomized female rat.


Gentianaceae alkaloids. Part IX: the structure of gentialutine and isogentialutine.


Effects of adrenalectomy on the aggressiveness of neonatally androgenized female mice.


Editorial: Neuroendocrinology and mental illness.


Effects of pretraining on subsequent cycloheximide induced amnesia.


Editorial: Endocrinology and psychiatry.


Morphine-like physical dependence: a pharmacologic method for drug assessment using the rat.


Reversible sodium pentobarbital amnesia in one trial discrimination learning.


Acute physical dependence in the waking dog after a single low dose of morphine.


Changes in acetylcholine content in rat brain after bilateral olfactory bulbectomy in relation to mouse-killing behavior.


Modification of delta9-THC-actions by cannabinol and cannabidiol in the rat.


Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons.


Proceedings: Ptosis as a model of depression.


Proceedings: Amine precursors in depression: studies combining L-DOPA and L-tryptophan.


Proceedings: Drugs, mood, and amines: a profile in psychobiological research.


Proceedings: Mean genes.

Proceedings: Mean genes.


Proceedings: The sociobiology of nonhuman primate aggression.


Proceedings: Biogenic amines and androgens in the study of aggressive behavior.


Mood, alertness and sympathetic-adrenal medullary activity during the menstrual cycle.


Incorporation of tritium from tritiated water into nucleic acids of Oryzias latipes eggs.


Central neurotransmitters in aggression.


Steroid hormones and aggressive behavior: approaches to the study of hormone-sensitive brain mechanisms for behavior.


Evidence for a sex difference in the neuropil of the rat preoptic area and its importance for the study of sexually dimorphic functions.


Special report on Senate Bill 667: Federal minimum standards of education for radiologic technologists.


Electrophysiological studies in an animal model of aggressive behavior.


The pancreatic secretion of enzymes in rats treated with soybean diet.


Skin carcinogenesis: cholesterol-5alpha,6alpha-epoxide hydrase activity in mouse skin irradiated with ultraviolet light. Cholesterol-5alpha,6alpha-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5alpha,6alpha-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.


Vitamin B 12 contents in fermented fish, fish sauce and soya-bean sauce.


Will this drug harm the unborn infant? The doctor's dilemma.


Transfer RNAs in early embryogenesis of fish. Communication I. Content of tRNA in the unfertilized egg and developing embryo of the loach (Misgurnus fossilis L.).


Effect of trypsin on spatial organization of early cleavage of the mollusks Limnaea stagnalis L. and Physa fontinalis L.


Principles of cell aggregation on the surface of a fixed cell monolayer.


Variability of silkworm (Bombyx mori L.) eggs in capacity for thermal parthenogenesis and heat resistance. Communication I. Familial variability and connection between heat resistance of embryos in early and late stages of development.


Variability of silkworm (Bombyx mori L.) eggs in capacity for thermal parthenogenesis and heat resistance. Communication II. Is there a connection between capacity of unfertilized eggs of different females for thermal parthenogenesis and heat resistance of fertilized eggs deposited by the same females?


Measurement of electrical coupling between cells of axolotl embryos during cleavage divisions.


Transfer RNAs in early fish embryogeny. Communication II. Synthesis of tRNAs at early developmental stages of the loach (Misgurnus fossilis L.)


Change in the membrane potential of fertilized sea urchin eggs under the action of certain neuropharmacological preparations.


Asphyxia neonatorum--assessment of the infant at birth.


Asphyxia neonatorum--neurological status at one year follow-up.


Age and sex dependence of food intake in the Mount Ayliff district.


Trace elements in plants and soil in relation to cancer.


Aflatoxin-induced tumors in mice.

Aflatoxin-induced tumors in mice.


The modified bovine arterial graft: a clinical study.


Clinical and hemodynamic comparisons of Kay-Shiley, Starr-Edwards No. 6520, and Reis-Hancock porcine xenograft mitral valves.


Carbon dioxide laser for laryngeal surgery.


Reduction in frequency of fetopathic effects of caffeine in mice by pretreatment with propranolol.


In vitro production of a chemotactic factor by inflammatory SH-dependent protease from rabbit and human immunoglobulin G subclasses.


Diurnal rhythms in tissue radioactivity uptake after 3H-estradiol and 3H-testosterone administration to castrated rats.


Effects of epinephrine on the estradiol action in the rat uterus.


Survival of ovarian allografts following maintenance in organ culture.


The fine structure of intra-erythrocytic stages of Theileria gorgonis and a strain of Anaplasma marginale isolated from wildebeest (Connochaetes taurinus).


Editorial: Fostering farriery.

Editorial: Fostering farriery.


Some observations on the use of two corticosteroid preparations for the induction of premature calving.


Letter: Mastitis in the mare.

Letter: Mastitis in the mare.


Anabolic steroids: possible uses in meat and milk production.


Torsion of the stomach in sows.

Torsion of the stomach in sows.


Letter: Development of the IT antigen.

Letter: Development of the IT antigen.


Biogenesis of vaccinia: concerning the origin of the envelope phospholipids.


The biotransformation of 8-chloro-6-phenyl-4H-s-triazolo(4,3-a) (1,4) benzodiazepine (D-40TA), a new central depressant, in man, dog and rat.


A simple rapid method for the removal of leukocytes from human blood. Filtration of human blood cells through lamb's wool columns removed more than 96% of all leukocytes in a series of experiments, while the retention of erythrocytes by the column averaged 6.4%. This method should prove extremely useful for obtaining pure erythrocyte preparations for use in biochemical and physiological studies, and for removing leukocytes from blood prior to transfusion.


Generalized lymphangiectosis associated with chylothorax; a possible dysplasia of the lymphatic system.


Vitamin-A intoxication causing papilledema and simulating acute encephalitis.


Chronic relapsing polyradiculoneuritis in a dog. A clinical, light- and electron-microscopic study.


Effect of essential fatty acid deficiency on brain lipids of developing rats.


Effect of trypsin and antipenton serum on the interferon inducing ability of human adenoviruses.


Electron microscopic study of human adenoviruses with different interferon inducing ability.


Bugs in the flowers: a review of the nonviolent ethic of the hippie subculture.


Adolescent pregnancy: intervention into the poverty cycle. Adolescent pregnancy, irrespective of the marital status of the mother, seems to be a determining factor in the incidence of female headed households, divorce, excessive fertility, and poverty.  In addition, the pregnant teenager is, obstetrically, a high risk patient, and her offspring, due to poor prenatal care and inadequate nutrition on the part of the mother, is likely to suffer in terms of physical and mental development.  This in turn will lead to further poverty, which will continue the cycle.  One way to interrupt the cycle may be by delaying the first birth to young adolescent girls.  There are 3 stages at which prevention can take place: preventing intercourse, preventing conception, and terminating pregnancy.  For the teenager, preventing conception seems the most feasible.  Effforts to design family planning programs especially for teenager should be expanded.  By this, 2 generation can benefit: the teenager herself and her potential offspring.


Sources of pseudomonas and acinetobacter species found in human culture materials.


Splenic hemopoiesis in idiopathic thrombocytopenic purpura.


Detection of fibrin degradation products. A comparison of counterimmunoelectrophoresis and two hemagglutination-inhibition methods.


Pure gonadal dysgenesis. Studies of in vitro androgen metabolism.


Decreased adhesion of giant (Bernard-Soulier) platelets to subendothelium. Further implications on the role of the von Willebrand factor in hemostasis.


Postnatal lead acetate exposure in rats: possible relationship to minimal brain dysfunction.


The regulatory effect of estrogens on fetal growth. III. Placental deoxyribonucleic acid, ribonucleic acid, and proteins.


Second-trimester fetoscopy and fetal blood sampling: current limitations and problems.


Monitoring induction of ovulation with human menopausal gonadotropin by a rapid estrogen radioimmunoassay. A study of human menopausal gonadotropin (HMG) in the induction of ovulation in 14 infertile, anovulatory women is presented.  All of the women had failed to ovulate following clomiphene therapy.  The dose of HMG administered in each of the 43 treatment cycles was determined by measuring the estrogen levels by either fluorimetric tests of total urinary estrogen, radioimmunoassay of serum estradiol, or a rapid 4-hour radioimmunoassay of  immunoreactive serum estrogen.  A significant correlation among the methods in establishing estrogen production obtained (r=.935; p less than .001).  38 of the 43 treatment cycles were presumed to be ovulatory, based on serum progesterone levels and basal body temperature.  7 of the 14 patients became pregnant (11 of the 38 ovulatory cycles).  There were 5 instances of mild ovarian hyperstimulation during the study.  The results demonstrate that the rapid radioimmunoassay technique for measuring serum estrogens, without chromatography, is capable of determining the extent of follicular maturation during HMG therapy.


Incidence of tetraploidy as related to amniotic fluid cell types.


The sequelae of cervical trauma.

The sequelae of cervical trauma.


Optometry college admission test.

Optometry college admission test.


Subependymal and intraventricular hemorrhages in the newborn. The pathogenesis of intraventricular hemorrhage in the newborn includes that of subependymal hemorrhage (SEH), the single most common pathologic alteration seen in the brains of 417 consecutively autopsied infants. A clearly recognizable relationship of SEH to gestational age and clinical status exists in that all SEH occur in premature infants under 2500 g birthweight (although only 56% of all premature infants have SEH) and 95% of SEH occur in infants with the respiratory distress syndrome (although only 60% of infants with the respiratory distress syndrome have SEH). The pathogenesis appears to involve a combination of hypoxia, metabolic acidosis, venous stasis and rupture of the thin-walled veins so prominent in the germinal matrix.


Animal model of human disease. Autosomal trisomy, developmental impairment and fetal death.


Professional, organizational, and social barriers to primary prevention.


Multivariate analysis of craniofacial measurements in twin and family data.


The perils of wizardry.

The perils of wizardry.


Professional standards review organizations: the current scene.


PSROs: problems and potentials for psychiatry.


Editorial: PSRO: a challenge to psychiatry.


Editorial: Suicide among psychiatrists.

Editorial: Suicide among psychiatrists.


Vibrio parahaemolyticus in the Republic of Korea.


Characterization of Thogoto virus isolated from ticks (Rhipicephalus bursa) in Western Sicily, Italy.


Bovine graft arteriovenous fistula for hemodialysis.


An epidemiologic assessment of heroin use.


Exploratory celiotomy for acute abdominal pain.


Measurement of DNA in cultured human cells.


Interference by Tris buffer in the estimation of protein by the Lowry procedure.


Fractionation of L-cell chromatin into DNA, RNA, and protein fractions on Cs2SO4 equilibruim density gradients.


The measurement of actin concentration in solution: a comparison of methods.


Modification of retrograde guide for endotracheal intubation.


Low-dose ketamine anesthesia for obstetrical delivery.


A flexible fiberoptic bronchoscope for endotracheal intubation of infants.


The effect of halothane anesthesia on intracranial pressure in the presence of intracranial hypertension.


Needle venting of air from intravenous tubing.


Profound hypotension associated with preoperative use of phenothiazines.


Informed consent and anesthesia.

Informed consent and anesthesia.


Treatment of chronic pain with bupivacaine epidural blocks.


The respiratory and narcotic antagonistic effects of naloxone in infants.


Ketamine in obstetrics: comparison with methoxyflurane.


Anesthetic problems in surgery for varying levels of respiratory obstruction in infants and children.


On-line computer scheduling of anesthesiologists.


The physician & the law. Anesthesiologist fails to obtain informed consent.


The relationship between S system of blood groups and potassium levels in red blood cells of cattle.


Reducing the risk of acid aspiration during cesarean section.


Effect of ketamine on the isolated chick embryo heart.


Epinephrine injection with enflurane anesthesia: incidence of cardiac arrhythmias.


Development and survival of Haemonchus contortus on pasture.


Cardiovascular and renal effects of enflurane in surgical patients.


Serum steroids after gonadotropin treatment in cows with ovarian follicular cysts.


Ovine ruminal acidosis: clinical studies.


Epidural anesthesia in Eisenmenger's syndrome: a case report.


Systolic and diastolic blood pressure measurements by transcutaneous Doppler ultrasound in premature infants in critical care nurseries and at closed-heart surgery.


Recovery of the retina from argon laser radiation: clinical and light microscopic evaluation.


The control of influenza.

The control of influenza.


General anesthesia for cataract surgery: a comparative review of 2217 consecutive cases.


Effect of epinephrine during enflurane anesthesia.


Management of retinal branch vein occlusion: the role of argon laser photocoagulation.


Effects of anticonvulsant drugs on enflurane cortical dysrhythmias.


Letter: Endotracheal intubation during delivery.


Control of cerebral perfusion pressure during induction of anesthesia in high-risk neurosurgical patients.


Investigation and management of varicose veins. The aspects of the anatomy and physiology of the lower limb which are concerned with venous return from the leg and its disorders are explored. It is shown that an understanding of the pathophysiology of this group of disorders forms the basis of a clinical classification. Recent advances in methods of assessment of the varicose leg are considered and it is shown that these can be used to supplement clinical evaluation. Finally, the relative merits of the two main methods of treatment are discussed.


Histones from exponential and stationary L-cells. Evidence for metabolic heterogeneity of histone fractions retained after isolation of nuclei.


Platelet dysfunction in essential thrombocythaemia.


Histones from exponential and stationary L-cells. Evidence for differential binding of lysine-rich and arginine-rich fractions in chromatin.


Deliberate hypotension in infants and children.


Acid-induced conformational change in hog thyroglobulin.


Hydrogen ion changes of rhodopsin. pK changes and the thermal decay of metarhodopsin II380.


Hydroxylation of peptide-bound proline and lysine before and after chain completion of the polypeptide chains of procollagen.


Plasma absorption of cyanocobalamin Co 57. Diagnostic value in vitamin B12 malabsorption states.


Autolytic activities associated with conjugation and sporulation in fission yeast.


Effects of selenium and of arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice.


Cytoarchitecture of the cochlear nuclei. Report of an illustrative case of erythroblastosis.


Letter: The osmolarity of Ringer's solutions.


Infertility in ewes caused by prolonged grazing on oestrogenic pastures: oestrus, fertilization and cervical mucus.


Studies on the carbohydrate of egg-white ovomucin.


Contact stimulation, androgenized females and accelerated sexual maturation in female mice.


The effects of food deprivation on agonistic behavior in an opisthobranch mollusc, Hermissenda crassicornis.


Sexual attraction function of golden hamster vaginal secretion.


Aggression as a component of relative fitness in four inbred strains of mice.


Endogenous levels of 15-keto-dihydro-prostaglandins in human plasma. Parameters for monitoring prostaglandin synthesis.


The action of alpha-amanitin in vivo on the synthesis and maturation of mouse liver ribonucleic acids. alpha-Amanitin acts in vitro and in vivo as a selective inhibitor of nucleoplasmic RNA polymerases. Treatment of mice with low doses of alpha-amanitin causes the following changes in the synthesis, maturation and nucleocytoplasmic transfer of liver RNA species. 1. The synthesis of the nuclear precursor of mRNA is strongly inhibited and all electrophoretic components are randomly affected. The labelling of cytoplasmic mRNA is blocked. These effects may be correlated with the rapid and lasting inhibition of nucleoplasmic RNA polymerase. 2. The synthesis and maturation of the nuclear precursor of rRNA is inhibited within 30min. (a) The initial effect is a strong (about 80%) inhibition of the early steps of 45S precursor rRNA maturation. (b) The synthesis of 45S precursor rRNA is also inhibited and the effect increases from about 30% at 30min to more than 70% at 150min. (c) The labelling of nuclear and cytoplasmic 28S and 18S rRNA is almost completely blocked. The labelling of nuclear 5S rRNA is inhibited by about 50%, but that of cytoplasmic 5S rRNA is blocked. (d) The action of alpha-amanitin on the synthesis of precursor rRNA cannot be correlated with the slight gradual decrease of nucleolar RNA polymerase activity (only 10-20% inhibition at 150min). (e) The inhibition of precursor rRNA maturation and synthesis precedes the ultrastructural lesions of the nucleolus detected by standard electron microscopy. 3. The synthesis of nuclear 4.6S precursor of tRNA is not affected by alpha-amanitin. However, the labelling of nuclear and cytoplasmic tRNA is decreased by about 50%, which indicates an inhibition of precursor tRNA maturation. The results of this study suggest that the synthesis and maturation of the precursor of rRNA and the maturation of the precursor of tRNA are under the control of nucleoplasmic gene products. The regulator molecules may be either RNA or proteins with exceedingly fast turnover.


Immobilized enzymes: the application of immobilized urate oxidase to the chemical analysis of uric acid in biological fluids.


Isolation and characterization of "8S" RNA in murine sarcoma virus-infected cells.


Structure activity relationships in a series of anti-neoplastic dinitrophenyl aziridines--protein binding studies.


DNA polymerases from non stimulated and phytohemagglutinin stimulated normal human lymphocytes.


Plasma enzymes as a measure of susceptibility of chickens and turkeys to infection with Histomonas meleagridis.


Kinetics of choline uptake in neuroblastoma clones.


Proceedings: Implications of PSRO to independent health professions.


Proceedings: PSRO and the quality of medical care.


Radioimmunoassay of plasma nicotine in habituated and naive smokers.


The population of cells in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis: significance and mechanism of increased immune lysis.


An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia.


Monozygotic and dizygotic twins reared together: sensitivity of heritability estimates.


Cellular hypersensitivity to uveal pigment confirmed by leucocyte migration tests in sympathetic ophthalmitis and the Vogt-Koyanagi-Harada syndrome.


Intracranial optic nerve angioblastoma.

Intracranial optic nerve angioblastoma.


Asymmetric distribution of histone on DNA: a model for nucleohistone primary structure.


Choline acetyltransferase and acetylcholinesterase: evidence for essential histidine residues.


The mechanism of activation of bovine factor X (Stuart factor) by intrinsic and extrinsic pathways.


Ultracentrifugal characterization of the mitochondrial ribosome and subribosomal particles of bovine liver: molecular size and composition.


Base pairing and template specificity during deoxyribonucleic acid repair synthesis in human and mouse cells.


Physical studies on egg phosphatidylcholine in diethyl ether- water solutions.


The activity of phospholipase A2 in reversed micelles of phosphatidylcholine in diethyl ether: effect of water and cations.


Nuclear magnetic resonance studies of the interaction of alamethicin with lecithin bilayers.


A histone cross-complexing pattern.

A histone cross-complexing pattern.


Conformational changes of histone ARE(F3, III).


Identification of an acylcholesterol lipase activity in human adipose tissue.


Studies on the interaction between gangliosides, protein and divalent cations.


The hydration of phospholipids.

The hydration of phospholipids.


ADP and Mg2+ requirement for Ca2+ accumulation by hog heart mitochondria. Correlation with energy coupling.


Enzymatic activity at interfaces. I. Enzymatic activity of trypsin at the air-water interface.


The role of molybdenum in the synthesis of nitrate reductase in cauliflower (Brassica oleracea L. var Botrytis L.) and spinach (Spinacea oleracea L.).


Elastase inhibitors as impurities in commercial preparations of Kunitz soybean trypsin inhibitor.


The subunit structure of lamprey fibrinogen and fibrin.


On the interaction of F-actin with fibrin.


Calcium ion-binding study on alpha-elastin.


Insulin degradation. XII. The amino acid composition, amino-terminal, and carbohydrate content of beef pancreatic glutathione-insulin transhydrogenase.


The synthetic polypentapeptide of elastin coacervates and forms filamentous aggregates.


The effect of detergents on the basicity of nitrotyrosine in proteins.


DNA repair in human/embryonic chick heterokaryons. Ability of each species to aid the other in the removal of ultraviolet-induced damage. Cultured human and embryonic chick fibroblasts possess different enzyme-mediated processes to repair cyclobutyl pyrimidine dimers induced in their deoxyribonucleic acid (DNA) by ultraviolet (UV) radiation. While dimers are corrected in human cells by excision repair, a photoenzymatic repair process exists in embryonic chick cells for the removal of these potentially deleterious UV photoproducts. We have utilized a sensitive enzymatic assay to monitor the disappearance, i.e. repair, of dimer-containing sites in fused populations of human and chick cells primarily consisting of multinucleate human/chick heterokaryons. Fused cultures were constructed such that UV photoproducts were present only in chick DNA when evaluating excision repair and only in human DNA when evaluating photoenzymatic repair. Based on the kinetics of site removal observed in these cultures we are led to conclude the following: Within heterokaryons per se the photoreactivating enzyme derived from chick nuclei and at least one excision-repair enzyme (presumably a UV endonuclease) derived from human nuclei act on UV-damaged DNA in foreign nuclei with an efficiency equal to that displayed toward their own nuclear DNA. Hence, after cell fusion these chick and human repair enzymes are apparently able to diffuse into foreign nuclei and once therein competently attack UV-irradiated DNA independently of its origin. In harmony with the situation in nonfused parental cultures, in heterokaryons the chick photoenzymatic repair process rapidly removed all dimer-containing sites from human DNA including the residual fraction normally acted upon slowly by the human excision-repair process.


Rheology of fibrin clots. II. Linear viscoelastic behavior in shear creep.


Diffusion controlled reaction rates in spheroidal geometry. Application to repressor--operator association and membrane bound enzymes.


Experimental studies of thermal denaturation of the Na-DNA system with respect to Manning's model.


Mirex in milk from Southeastern United States.


Interaction of p,p' DDT with histomoniasis in bobwhites.


Feeding studies with Randox in the dairy cow.


Dieldrin contamination of milk by use of second-hand bags for feed.


Toxicity of phthalate esters to nervous tissue in culture.


Production of dimethylselenide gas from inorganic selenium by eleven soil fungi.


Toxic effect of cadmium stearate on rat cerebellum in culture.


Effect of physical exertion on the diurnal rhythm of the nucleo-cytoplasmic ratios and hepatocyte nuclear volumes in some mammals.


Editorial: Normal short children.

Editorial: Normal short children.


On the stability of the mechanical properties of self-curing acrylic bone cement.


Editorial: More facts on vinyl chloride and cancer.


Idiopathic torsion dystonia (dystonia musculorum deformans). A review of forty-two patients.


A further study on the effect of physostigmine on memory in rats.


Ceramide biosynthesis in mouse brain microsomes: comparison between C57-BL controls and quaking mutants.


Biochemical correlates in mouse-killing behavior of the rat: brain acetylcholine and acetylcholinesterase after administration of delta9-tetrahydrocannabinol.


Post-castration decline in behavioural responsiveness to intrahypothalamic androgen in doves.


Editorial: Infants and institutions.

Editorial: Infants and institutions.


Specialization in large animal practice.


The future of large animal practice - a government support program for veterinary services.


Occult thyroid carcinoma in Olmsted County, Minnesota: prevalence at autopsy compared with that in Hiroshima and Nagasaki, Japan.


TfM mutation and masculinization versus feminization of the mouse central nervous system.


DNA-dependent RNA polymerase activity of Chinese hamster kidney cells sensitive to high concentrations of alpha-amanitin.


The pattern of concanavalin A-binding sites during the early development of Xenopus laevis.


The effect of cell proliferation of reduced substrate adhesiveness.


Embryonic cell aggregation: absence of galactosyltransferase activity in retina-specific cell-aggregating factor.


A reliable method for the specific determination of testosterone in plasma.


Properties of microsomal glycoprotein galactosyltransferase of cultured human fibroblasts in relation to cystic fibrosis.


Radioimmunoassay of methotrexate in biological fluids.


The simultaneous separation and washing of erythrocytes.


Editorial: The development of PSROs in Connecticut.


Toxoplasmosis in a farmer's family and in the Eastern Townships, Province of Quebec.


Effect of hyaluronidase on hamster chromosomes structure.


The siamang in Malaya. A field study of a primate in tropical rain forest.


The effect of circulating prostaglandin antibodies on reproduction in rabbits with special reference to the placenta.


Cyclic activity of estrogen sulfotransferase in the gilt uterus.


Temporal interrelationships among circulating levels of estradiol, progesterone and LH during the rat estrous cycle: effects of exogenous progesterone.


Proceedings: Impairment of upper alimentary vagal function in diabetes.


Dynamics of changes of calcium and phosphorus metabolism in relation to the morphology of parafollicular thyroid cells in rats during lactation and forced weaning.


Initiation does not limit the rate of globin synthesis in message-injected Xenopus oocytes.


The synthesis of three AMP-analogues: N6-(6-aminohexyl)-adenosine 5'-monophosphate, N6-(6-aminohexyl)-adenosine 2',5'-bisphosphate, and N6-(6-aminohexyl)-adenosine 3',5'-bisphosphate and their application as general ligands in biospecific affinity chromatography.


Further observations on the effect of PHA in conjunction with radiotherapy and chemotherapy on S-180 in Swiss mice.


Extrapyramidal and mesolimbic involvement with the stereotypic activity of D- and L-amphetamine.


Inhibition by aspirin of ribose conjugation in the metabolism of histamine.


Replication of repetitious DNA in synchronized chick fibroblast cells.


Metabolic studies of skeletal muscle regeneration.


Diurnal rhythm of choline-14C incorporation into lecithin in Ehrlich-Lettré ascites tumour cells.


Incorporation of thymidine into the chromosomes of aphid (Myzus persicae) embryos.


Influence of 2-Br-alpha-ergokryptine-mesilate (CB 154) on the pituitary prolactin content of prooestrus rats.


Possible circadian and seasonal rhythmicity in an in vitro model: monoamine uptake in rat brain slices.


Dopamine receptor blockade by neuroleptic drugs in Aplysia neurones.


Intra-retinal absorption of argon laser irradiation in human and monkey retinae.


The synthesis of light chain immunoglobulin in MPC-11 cells on only one of two fractions of membrane-bound polysomes prepared by a combination of nitrogen cavitation/detergent treatment.


Regeneration of limbs in newly metamorphosed toadlets of Bufo regularis Reuss.


A solid phase radioimmunoassay for urine aldosterone using antibodies linked to nylon nets.


A kinetic analysis of the changes in membrane permeability induced by fertilization in the egg of the sea urchin Sphaerechinus granularis.


Quantitative measurement of active polysomes of developing chick muscle.


Mechanism of soybean trypsin inhibitor induced polyspermy as determined by an analysis of refertilized sea urchin (Arbacia punctulata) eggs.


Comparison of the penetrability of the egg vestments in follicular oocytes, unfertilized and fertilized ova of the rabbit.


Replication of mitochondrial DNA in the early development of Misgurnus fossilis.


Expression of lactate dehydrogenase phenotypes in intraspecific and interspecific matings of two species of Xenopus.


Histones of chick embryonic lens nuclei.


Experiences in the production control and field application of vaccine and serum against bovine virus diarrhea in Hungary.


A model for carcinoma of the kidney in Buffalo strain rats ingesting N-4-(4'-fluorobiphenyl)acetamide.


Plasmodium formation without change in nuclear DNA content in Physarum polycephalum.


Damage of mammalian cell DNA in vivo and in vitro induced by neocarzinostatin.


Experimental Mycoplasma hominis i infection in the pregnant rat. A possible model for studies of teratogenesis.


Uptake of some cations by Candida utilis.


Production of nematode-attracting and nematicidal substances by predacious fungi.


Extracorporeal support of the fetal lamb simulating in utero gas exchange.


Intra-specific variation in the social organization and ecology of Propithecus verreauxi.


Chronological changes of bacteria isolated from the urine of out-patients with urinary tract infection.


Kinetic studies on the phospholipid metabolism of embryonic mouse cells under conditions of stimulated or restrained growth.


The action of brain phospholipases A2 on purified, specifically labelled 1,2-diacyl-, 2-acyl-1-alk-1'-enyl- and 2-acyl-1-alkyl-sn-glycero-3-phosphorylcholine.


Some characteristics of highly purified boar sperm acrosin.


Kinin-induced enhancement of sperm motility.


Solid-phase synthesis of the biologically active N-terminal 1 - 34 peptide of human parathyroid hormone.


Microfluorimetric study of metabolic alterations in Ehrlich ascites tumor cells following serial cultivation in hypertonic media.


Sigmoid kinetics of the monomeric ribonuclease I due to ligand-induced shifts of conformation equilibria.


Alternative pathways in the biosynthesis of sphingomyelin and the role of phosphatidylcholine, CDPcholine and phosphorylcholine as precursors.


Production and properties of sodio-tolerant L cells.


Aggression in the female golden hamster: effects of reproductive state and social isolation.


Influence of alpha, alpha-dipyridyl on the biosynthesis of collagen in organ cultures.


Plasma testosterone and male dominance in a Japanese macaque (Macaca fuscata) troop compared with repeated measures of testosterone in laboratory males.


Chemical and immunological nature of Forssman hapten in sheep erythrocytes.


The induction of tolerance to a soluble protein antigen by oral administration.


Plasma lipo-protein lipase activity in patients of ischaemic heart disease and normal controls.


Plasma oxytocinase and onset of labour.

Plasma oxytocinase and onset of labour.


Climatic adaptation in recently shorn merino sheep.


Letters to the editor: The epidemiology of suicide attempts.


Antigenic differences between isolates of herpesvirus type 2.


Penetration of nuclear inclusions into the cytoplasm in influenze-virus-infected cells.


Variation in the coxsackievirus type B5 and its possible role in the etiology of swine vesicular disease.


Reovirus transcriptase activation in vitro: further studies on the facilitation phenomenon.


Traumatic uterine synechiae.

Traumatic uterine synechiae.


Temperature-sensitive mutants of reovirus. VI. Mutant ts 447 and ts 556 particles that lack either one or two genome RNA segments.


Incidence of cystic ovaries in Holstein-Friesian cows.


Necrotizing myelopathy in five great danes.


Reproductive physiology of the stallion: spermatozoal losses in the collection equipment and gel.


Therapeutic use of a phantom for semen collection from a stallion.


Hydration and pH of microbially spoiling beef.


Isolation and characterization of a new antitumor antibiotic OS-3256-B from Streptomyces candidus var. azaticus.


Effect of formaldehyde on fungi from broiler houses.


Kinetics of human growth hormone during submaximal exercise.


A viscoelastic-mass mechanism as a basis for normal postural tremor.


Carotenoid biosynthesis in Rhodotorula glutinis. It was determined that lycopene could be cyclized directly by Rhodotorula glutinis. It was also shown the the temperature effect (i.e., increased beta-carotene synthesis in response to lower incubation temperatures) in R. glutinis was controlled by changes in enzyme concentration.


An improved chromatographic method for the analysis of iodoamino acids in thyroglobulin.


Dissociation of bovine liver catalase into subunits on acetylation.


Uridine diphosphoglucose pyrophosphorylase activity and differentiation in the cellular slime mold Physarum polycephaluno. The specific activity of uridine 5'-triphosphate:alpha-d-glucose 1-phosphate uridyltransferase (EC 2.7.7.9) (also called uridine 5'-diphosphate [UDP]-glucose pyrophosphorylase) has been found to increase up to eightfold during spherule formation by the slime mold Physarum polycephalum. The enzyme accumulates during the first 8 to 9 h after initiation of spherule formation, declines to basal levels found in vegetative microplasmodia by 15 h, and is undetectable in completed spherules. Specific activities for UDP-glucose pyrophosphorylase in vegetative microplasmodia range from 15 to 30 nmol of UDP-glucose formed per min per mg of protein, whereas accumulated levels during spherule formation can attain a specific activity as high as 125 nmol of UDP-glucose formed per min per mg of protein. The scheduling and extent of accumulation are critically dependent on an early log-phase age of microplasmodia originally induced to form spherules. Spherule induction by 0.2 M or 0.5 M mannitol delays this schedule in a variable and unpredictable manner. Spherule-forming microplasmodia which have accumulated high levels of UDP-glucose pyrophosphorylase spontaneously excrete the enzyme when transferred to salts medium containing 0.2 M or 0.5 M mannitol. The excreted enzyme is subsequently destroyed or inactivated. Studies with preferential inhibitors of macromolecular synthesis indicate that accumulation of UDP-glucose pyrophosphorylase requires concomitant protein synthesis and prior ribonucleic acid synthesis.


Role of tubulin-SH groups in polymerization to microtubules. Functional-SH groups in tubulin for polymerization.


Mode of action on proteins of acid carboxypeptidase from Aspergillus saitoi.


Microdetermination of individual neutral and amino sugars and N-acetylneuraminic acid in complex saccharides.


Bovine plasma kininogens. I. Further purification of high molecular weight kininogen and its physicochemical properties.


Bovine plasma kininogens. II. Microheterogeneities of high molecular weight kininogens and their structural relationships.


A histone deacetylase capable of deacetylating chromatin-bound histone.


Synthesis and characterization of the duplex block polymer d(C15A15)-d(T15G15).


Studies of the energy-dependent uptake of divalent metal ions by beef heart mitochondria.


Bovine erythrocyte superoxide dismutase. Isolation and characterization of tryptic, cyanogen bromide, and maleylated tryptic peptides.


Modification of pepsinogen with pyridoxal phosphate.


Protein assembly of procollagen and effects of hydroxylation.


Some biochemical properties of Chinese hamster cells sensitive and resistant to actinomycin D. A graded series of drug-resistant Chinese hamster sublines has been examined for biochemical changes accompanying resistance to actinomycin D. The most highly resistant subline, DC-3F/AD X, is maintained at 10 microg/ml of the antibiotic. It was shown that over 250 times more actinomycin D is required to inhibit RNA synthesis in this subline than in the parental DC-3F line. The DC-3F/AD X subline was also shown to have a somewhat reduced capacity to transport uridine as compared to parental cells. Sensitive cells took up over 50 times more tritiated antibiotic than the most resistant cells, as determined in a 1-h assay. Uptake of actinomycin D was shown to be temperature-dependent in both resistant and sensitive cells and was not influenced by various metabolic inhibitors. Resistance could not be explained by a rapid uptake and release of the antibiotic, as demonstrated in efflux experiments, or by its metabolism. In addition, highly resistant cells which are cross-resistant to puromycin were shown to have a reduced capacity to take up labeled puromycin. These studies provide further evidence indicating that the mechanism of resistance to actinomycin D is reduced permeability to drug and suggesting that cell membrane alteration accounts for resistance to both actinomycin D and puromycin.


Cell contact dependence of surface galactosyltransferase activity as a function of the cell cycle. Mitotic, nonmalignant Balb/c 3T3 cells exhibit endogenous, surface galactosyltransferase activity that does not require intercellular contact throughout the assay period. In this respect, mitotic 3T3 cells resemble malignant Balb/c 3T12 cells which similarly show no contact requirement for optimum transferase activity in any phase of their cell cycle. Previously, it was shown that randomly growing populations of 3T3 cells have lower galactosyltransferase activity when assayed under conditions which decreased cell contact. This led to the conclusion that these normal (3T3) and malignant (3T12) cells differed in that intercellular contact is required for optimum activity of surface galactosyltransferases on the normal cell type. The present data indicate that mitotic 3T3 cells may be capable of expressing enzyme activities exhibited at all times by malignant cells. That is, mitotic 3T3 cells and randomly growing 3T12 cells may readily catalyze galactosyltransferase reactions between enzymes and acceptors on the same cell. Interphase 3T3 cells, on the other hand, might require that enzymes glycosylate acceptors on adjacent cells. A model is proposed that suggests that changes in the spatial arrangement of surface enzymes and acceptors or variations in the fluidity of the cell membrane can account for this contact-related glycosylation.


The action of alpha-amanitin on RNA synthesis in Chinese hamster ovary cells. Ultrastructural and biochemical studies. alpha-Amanitin acts in vitro as a selective inhibitor of the nucleoplasmic form B RNA polymerases. Treatment of Chinese hamster ovary (CHO) cells with this drug leads principally to a severe fragmentation of the nucleoli. While the ultrastructural lesions induced by alpha-amanitin in CHO cells and in rat or mouse liver are quite similar, the results diverge concerning the effect on RNA synthesis. It has been shown that in rat or mouse liver alpha-amanitin blocks both extranucleolar and nucleolar RNA synthesis. Our autoradiographic and biochemical evidence indicates that in CHO cells high molecular weight extranucleolar RNA synthesis (HnRNA) is blocked by the alpha-amanitin treatment, whereas nucleolar RNA (preribosomal RNA) synthesis remains unaffected even several hours after the inhibition of extranucleolar RNA synthesis. Furthermore, the processing of this RNA as well as its transport to the cytoplasm seem only slightly affected by the treatment. Finally, under these conditions, the synthesis of the low molecular RNA species (4-5S) still occurs, though less actively. The results are interpreted as evidence for a selective impairment of HnRNA synthesis by alpha-amanitin in CHO cells.


Purified multiplication-stimulating activity from rat liver cell conditioned medium: comparison of biological activities with calf serum, insulin, and somatomedin.


Some biological characteristics of a pituitary growth factor (CGF) for cultured lapine articular chondrocytes.


Formation of eosinophilic-like granulocytic colonies by mouse bone marrow cells in vitro.


Biochemical criteria for the in vitro differentiation of embryoid bodies produced by a transplantable teratoma of mice. The production of acetylcholine esterase and creatine phosphokinase by teratoma cells.


Morphological criteria for the in vitro differentiation of embryoid bodies produced by a transplantable teratoma of mice.


Contact inhibition, polyribosomes, and cell surface membranes in cultured mammalian cells.


Expression of the neuron-specific protein, 14-3-2, and steroid sulfatase in neuroblastoma cell hybrids.


Manipulation of avoidance behavior as a function of increased or decreased demand on repeated behavioral tests.


Decreased insulin binding to lymphocytes from diabetic subjects. We have studied insulin binding to circulating lymphocytes isolated from 20 untreated adult, nonobese, nonketotic, diabetic subjects with fasting hyperglycemia, 20 normal subjects, and four patients with fasting hyperglycemia secondary to chronic pancreatitis. The results of these studies show that lymphocytes from diabetic patients have decreased ability to specificity bind insulin when compared to lymphocytes from normal subjects. For example, when lymphocytes from diabetic patients and a trace amount of [(125)I]insulin (3.3 x 10(-11) M) were incubated, binding was less than 50% of the value obtained with lymphocytes from normal subjects (2+/-0.2% vs. 4.2+/-0.4%). Furthermore, the data show that lymphocytes from diabetic patients have only 1,200 insulin receptor sites per cell compared to 2,200 sites per cell for lymphocytes from normal subjects. Competitive inhibition studies using unlabeled insulin indicate that the affinity for insulin of lymphocytes from both groups is comparable. Consequently the decreased insulin binding of diabetics' lymphocytes is primarily due to a decreased number of available receptors rather than decreased binding affinity. This decreased insulin binding is not due to chronic hyperglycemia since insulin binding to lymphocytes, obtained from four patients with fasting hyperglycemia secondary to chronic pancreatitis, was completely normal. The possibility that some factor present in the plasma of diabetic patients could cause decreased insulin binding also seems unlikely since we could demonstrate no in vitro effects of diabetics' plasma on insulin binding. Lastly, the proportion of lymphocytes which were thymus derived and bone marrow derived were the same in each of the study groups indicating that differences in lymphocyte subpopulations do not account for our results. (a) lymphocytes from nonobese, untreated, adult diabetic patients with fasting hyperglycemia demonstrate a decreased ability to bind insulin; (b) this decreased insulin binding to lymphocytes obtained from diabetic patients can be accounted for primarily by an absolute decrease in the number of available receptor sites per cell; and (c) these data suggest that this defect in insulin binding is a primary phenomenon.


Letter: Reactions of vinyl ethers with cobalamins and cobaloximes.


Letter: Carbon magnetic resonance study of the conformational changes in carp muscle calcium binding parvalbumin.


Human parathyroid hormone. Immunological characterization of antibodies against a glandular extract and the synthetic amino-terminal fragments 1-12 and 1-34 and their use in the determination of immunoreactive hormone in human sera. Antibodies to a urea-trichloroacetic acid extract [hPTH-(TCA)] of human parathyroid tumors and to the synthetic NH(2)-terminal fragments of human parathyroid hormone hPTH-(1-12) and -(1-34) were developed in goats to characterize immunochemically various PTH preparations and to estimate immunoreactive PTH (iPTH) in human sera. They were quantitated on the basis of their capacity to bind [(131)I]-hPTH-(1-12), [(131)I]hPTH-(1-34) or [(131)I]bovine PTH (bPTH-(1-84)). The quality of the antibodies was assessed by reference to inhibition of their interaction with labeled peptides by synthetic hPTH comprising 34 NH(2)-terminal amino acid residues or fragments thereof [hPTH-(1-12), -(13-34), -(18-34), -(25-34), -(18-24)] or by the Sephadex G-100-purified full-length peptide hPTH-(1-84) [hPTH-(1-84)G-100]. The synthetic peptides used in this work correspond in their structure to the NH(2)-terminal amino acid sequence 1-34, as elucidated by Brewer and collaborators (1972. Proc. Natl. Acad. Sci. U. S. A.69: 3583-3588). Inhibition studies were also carried out with bPTH-(1-34) and bPTH-(1-84). Anti-hPTH-(TCA) exhibited specificities directed to determinants in the COOH-terminal and NH(2)-terminal part of hPTH-(1-84) and exhibited cross-reactivity with bPTH-(1-84). Anti-hPTH-(1-34), on the other hand, showed immunological specificities mainly directed to antigenic determinants located in the COOH-terminal half of hPTH-(1-34). In addition, some reactivity with the NH(2)-terminal hPTH-(1-12) and with the extractive full-length peptides of human and bovine origin was observed. Antibodies to hPTH-(1-12) cross-reacted with hPTH-(1-34) and -(1-84)G-100.IPTH WAS RADIOIMMUNOLOGICALLY DETERMINED IN HUMAN SERA BY THE FOLLOWING SYSTEMS: (a) [(131)I]bPTH-(1-84), anti-hPTH-(TCA) and hPTH-(1-84)G-100 as standard; (b) [(131)I]hPTH-(1-34), anti-hPTH-(1-34) and hPTH-(1-34) as standard. With system (a), COOH-terminal fragments of hPTH-(1-84) having a molecular weight of approximately 7,000 were detected, and there was an almost total discrimination of serum iPTH levels in normal and in hyperparathyroid subjects. With system (b), on the other hand, several molecular species of iPTH were detected, including a component larger than hPTH-(1-84) and others similar to hPTH-(1-84) and to a fragment co-eluting with the NH(2)-terminal fragment hPTH-(1-34). When serum iPTH was assayed in system (b), there was a large overlap of iPTH levels in control subjects and in patients with primary hyperparathyroidism.


A sensitive microelectrophoretic method for measuring the anti-platelet activity of horse anti-human lymphocyte serum.


Editorial: Peer review and all that.

Editorial: Peer review and all that.


Comparative evaluation of the isotopes 86Rb and 51Cr in a humoral cytotoxicity system.


The localization and fate of concanavalin A in amoebae of the cellular slime mold, Dictyostelium discoideum.


Precursor-product relationships between nucleotides and RNA during differentiation in Dictyostelium discoideum.


Parasexual genetics in Dictyostelium discoideum: mitotic analysis of acriflavin resistance and growth in axenic medium.


Evidence for mitotic crossing-over during the parasexual cycle of the cellular slime mould Dictyostelium discoideum.


Regulation of aromatic metabolism in fungi: selection of mutants of the yeast Rhodotorula mucilaginosa with nystatin.


Regulation of aromatic metabolism in the fungi: metabolic control of the 3-oxoadipate pathway in the yeast Rhodotorula mucilaginosa.


Deoxyribonucleic acid of Marek's disease virus in a lymphoblastoid cell line from Marek's disease tumours.


The mechanisms of neutralization of sensitized equine arteritis virus by complement components.


Changes in biogenic amine synthesis and turnover induced by hypoxia and/or foot shock stress. I. The adrenal medulla.


Unusual profiles in organotypic cultures of central nervous tissue.


Habituation of the motion detectors of the crayfish optic nerve: their relationship to the visually evoked defense reflex.


The role of substituted anisoles in epidermal micro-invasion.


A method for the isolation of Schistosoma mansoni eggs.


Carbohydrate and protein in Lymnaea stagnalis eggs and Trichobilharzia ocellata cercariae.


A possible function of the fibrillar coat in Acanthocephalus jacksoni eggs.


Enhancement of virulence and immunogenicity of Nematospiroides dubius.


Fate of adult Dipetalonema viteae transferred intraperitoneally to jirds.


Preparation of sterile Toxocara canis larvae.


Prevalence of eyeworm in three populations of Columbian black-tailed deer in northwestern Oregon.


Identification and synthesis of di-(1-phenylisopropyl)methylamine, an impurity in illicit methamphetamine.


Specific antibody activation of lymphocytes for cell-mediated cytotoxicity against cultured target cells.


Anaesthetics and the general practitioner.


Characteristics of heterologous membrane antigen on cultured human cells.


Choriocarcinoma in Ibadan, Nigeria: epidemiologic aspects.


Analytic techniques in the separation and identification of specific purine and pyrimidine degradation products of tRNA: application to urine samples from cancer patients.


Cell proliferation in mammary epithelium and correlated histochemical fluctuations in mast cells during the estrous cycle.


BCG therapy given as an adjuvant to surgery: prevention of death from metastases from mammary adenocarcinoma in rats.


Malignant schwannomas of nerve roots, uterus, and epididymis in mice.


Periurethral striated muscle activity in neurogenic bladder dysfunction.


Metastatic choriocarcinoma with 30-month survival.


Effects of serum on the growth of prostatic cells in vitro.


Toxoplasmosis in pallas cats.

Toxoplasmosis in pallas cats.


Studies on protein binding of cefazolin and other antibiotics.


Production of high titer antisera against sialoglycosphingolipids and their characterization using sensitized liposome.


Occurrence of cholesteryl sulfate in eggs of the sea urchin, Anthocidaris crassispina.


On the pathogenesis of the uremic state--an exposition of the trade-off hypothesis.


Inhibitory action of human and rat placental extracts on myometrial activities of mouse and rat.


Bloodless method for measurement of pulmonary blood flow.


Feline panleukopenia in Japan. I. Isolation and characterization of the virus.


The effect of age on the turnover rate of potassium in the rat.


An electron microscopical study on effects of synthesized estrogen on the anterior pituitary of male mice.


Nonheme iron mobilization from the liver in piglets.


Enhancement of liver UDP-glucose dehydrogenase caused by an effective glucosidurogenic compound, eugenol.


Pathological studies on proventricular ulcer in swine.


Cellulose acetate membrane electrophoresis of bovine serum proteins using a barbital calcium buffer.


Clinical studies on congenital heart disease in the dog. I. Clinical diagnosis and treatment of patent ductus arteriosus.


Local immunization in chicken respiratory tract with killed Mycoplasma gallisepticum vaccine.


Field surveys on coccidial infection in broilers in Japan--results obtained in spring and summer in 1973.


Histopathological studies on inclusion body hepatitis in broiler chickens.


Multiple headed spermatozoa in the boar testes.


Spontaneous Brucella canis infection in beagles: bacteriological and serological studies.


A serological survey on hemagglutinating encephalomyelitis virus infection in pigs in Japan.


Characterization and differentiation of mycoplasmas of canine origin.


Comparative electrocardiographical studies on the conduction time of heart in vertebrates.


Effect of fasting on ferrokinetics in piglets.


The perfect state of Microsporum canis.

The perfect state of Microsporum canis.


Colorimetric determination of sugars in sweetened condensed milk products.


Haemangiosarcoma of bone in the dog.

Haemangiosarcoma of bone in the dog.


Repair of hepatic and splenic injuries by autoplastic peritoneal patches and butyl-2-cyanoacrylate monomer. An experimental study.


Some symmetry considerations for the fibrinogen-fibrin assembly system.


The mechanism of microtubule assembly in vitro.


Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin.


The state of the art of quality assessment--1973.


Evaluating health care.

Evaluating health care.


Feasibility of multichannel scala tympani stimulation.


Letter to the editor: Delta-and epsilon-hydroxylation of keto acid by mushrooms.


Ratios of polyunsaturated fatty acids to alpha-tocopherol in tissues of rats fed corn or soybean oils.


Control of myocardial oxygenation-effect of atrial pacing.


Fatty acid biosynthesis by avocado pear.


Biologic clocks and canine neuroses.

Biologic clocks and canine neuroses.


A method of indirect mutant selection in Physarum polycephalum using the antibiotic netropsin.


Kinetics of the proteolysis of aspartate aminotransferase in various states of the active site.


A study of the conformational states of aspartate aminotransferase by perturbation spectrophotometry. I. The change in the accessibility of the coenzyme during the enzymatic reaction.


An investigation of the conformational mobility of the active center of D-glyceraldehyde 3-phosphate dehydrogenase.


Studies on the rhizosphere mycoflora of broad bean and cotton. IV. The influence of the rhizosphere fungi on plant growth.


Salinity tolerance and ecological aspects of some microfungi from saline and non-saline soils in Wyoming.


A preliminary survey of yeasts isolated from marine habitats at Abaco Island, The Bahamas.


Physiology of spore germination in Cephalosporium acremonium.


Epidermophyton stockdalae Sp. Nov.

Epidermophyton stockdalae Sp. Nov.


Pathogenicity of Alternaria alternata and its antibody production in experimental animals.


Effects of nitrogen sources at various temperatures on Papulospora thermophila.


Keratinophilic fungi of the Galapagos Islands.


On the composition of casein micelles isolated under different conditions of ultracentrifugation.


Pupils of a talking parrot.

Pupils of a talking parrot.


Changes in heroin self-administration by a rhesus monkey after morphine immunisation.


Spermatozoa motility in human cervical mucus.


Egg activation in Pimpla turionellae (Hym.).


Association of mammalian cell death with a specific endonucleolytic degradation of DNA.


Secondary sex ratio in ten inbred strains of mice.


Letter: Malignant Brenner tumor.

Letter: Malignant Brenner tumor.


Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines.


Clonal karyotype evolution in solid tumours in children.


Misdirection of facial nerve fibers in Bell's palsy.


Myogenic potentials evoked by oscillatory stimulation.


Tinnitus due to abnormal contraction of stapedial muscle. An abnormal phenomenon in the course of facial nerve paralysis and its audiological significance.


Congenital subglottic atresia.

Congenital subglottic atresia.


The fine surface view of the pharyngeal tonsil.


In vitro study of the immunological function of the rabbit tonsil.


Human nasal sero-mucinous glands after permanent tracheostomy. Electron microscopic study.


Changes of gastrointestinal motility evoked by spinal cord cooling and heating.


Absence of effect of intraaortal glucose infusions upon spontaneous meals of rats.


In vivo studies on uricase activity in the rat.


Lipid metabolism in the potassium deficient rat.


Origin of impulse initiation in the slowly adapting stretch receptor of the crayfish.


Heterogeneity of guinea pig papillary muscle revealed by systematic variations in the upstroke of the action potential.


Hostaflon TF coating of tungsten sensory micro-needles.


Arboviral infections and rabies.

Arboviral infections and rabies.


Tobacco-smoke inhalation delays suckling-induced prolactin release in the rat.


Corpus luteum and estrous cycle influence on physiological properties of ewe utero-ovarian arteries.


RNA and protein synthesis in control and follicularly-aged rat oocytes.


The effect of mating on the afternoon of proestrus on serum LH (and FSH) and ovulation in the rat. Possible relationships between coitus and serum gonadotrophin levels and ovulation in the rat were investigated.  Female rats were mated betw een 1700 and 1730 or between 1800 and 1830 hours.  1.3 ml of blood was withdrawn by cardiac puncture 30 minutes postcoitus for luteinizing hormone (LH) analysis.  After autopsy on the morning of estrus, counts were made of tubal ova, and LH and follicle-stimulating hormone (FSH) were measured in terminal blood from all animals.  Those mated at 1700-1730 with no cardiac puncture showed significantly more ova than those with cardiac puncture (p less than .05) and those which were neither mated nor received cardiac puncture (p les than .05).  No differences were found between those mated at 1800-1830 hours because of the large variance in each group.  Coitus during the time of normal mating did not increase LH levels 30 minutes postmating or terminal LH and FSH levels.  Terminal LH levels were significantly increased in the no cardiac puncture-no mate animals (p less than .05) in comparison with the cardiac puncture-no mate animals.


Diurnal fluctuations in acetylserotonin methyltransferase (ASMT) activity in the pineal gland of the steelhead trout (Salmo gairdneri),.


Studies on plasma protein binding of carbamazepine.


Intravenous alcohol self-administration in the rat.


Maternal pheromone.

Maternal pheromone.


Retrograde amnesia: storage failure versus retrieval failure.


Implications of recovery from experimental amnesia.


Effects of isolation on aggression in the Mongolian gerbil.


Biological effects of natural and artificial aerosols.


Comparative reactivity of cytidine and arabinosylcytosine to their 6-methyl derivatives in the presence of cytidine deaminase.


Studies on the levels and nature of cholinesterase in human and mouse placenta.


Profile-based-therapy (PBT) in schizophrenias. A preclinical indication for the use of dihydroxyphenylserine (DOPS).


Effect of morphine on brain and plasma sialic acid levels in the rat.


Blood group and behavioral differences among dizygotic twins: a failure to replicate.


Letter: Miner's syndrome.

Letter: Miner's syndrome.


The use of vincristine in refractory auto-immune thrombocytopenic purpura.


Effects of anaesthesia with a high oxygen concentration on the acid-base state of babies delivered at elective Caesarean section.


Nonventilatory benefits of respiratory support during irreversible hemorrhagic shock.


Successful correction of tricuspid atresia: results of a detailed anatomical study.


Lack of toxicity of transfused carboxyhemoglobin red blood cells and carbon monoxide inhalation.


Future use and development of eye-care manpower.


Acute renal and hemodynamic responses to methylprednisolone in experimental cardiogenic shock.


Transfer of delayed hypersensitivity to dinitrochlorobenzene and PPD by thymic extract in guinea pig and man.


Clinical evaluation of human chorionic gonadotropin levels in men with testicular tumors.


Experience with sigmoid conduits in urinary diversion.


Experimental scoliosis in fetal lambs.

Experimental scoliosis in fetal lambs.


Circadian variations of plasma renin activity and plasma osmolality in various physiological and pathological states.


Effect of Gymnodinium breve toxin on potassium influx of erythrocytes.


Hemolysis of rabbit and mullet red cells by Gymnodinium breve toxin.


Photon activation of biological samples and patients irradiated with a betatron.


The Barbados Family Planning Association and fertility decline in Barbados.


Probit analysis of cytotoxicity data.

Probit analysis of cytotoxicity data.


Epidemiology of clinical Q fever in Northern Ireland.


Caprine theileriasis in Sierra Leone: first recorded cases.


Letter: Welfare of livestock on the farm.


Effect of artificial daylight changes on the reproductive rate of sheep.


Practical experiences with bovine serum in quality control.


Quantitative estimation of isoenzyme patterns in human tissues by immunotitration.


Aldolase isoenzymes: activities in healthy persons and twins.


An affinity chromatographic study of trypsinogen activation. Kinetic evidence for the existence of neotrypsinogen.


Interaction of quinacrine mustard with whole and partially deproteinized calf thymus deoxynucleoproteins.


The follow-up history of children from multiple pregnancies.


Further development of children from multiple pregnancy.


Psychomotor development and the postnatal fate of children from multiple pregnancy.


Development of premature twins with dissimilar birth weight. I. Physical development.


Development of premature twins with dissimilar birth weight. II. Mental development.


Psychomotor development of twins in the first six months of life.


The mental development of children from multiple pregnancy.


Psychomotor development of children from multiple pregnancies. A psychological evaluation.


Some aspects of the physical and mental development of triplets.


Frequency of malignant tumours in diabetes mellitus.


Effect of living conditions on the development of multiplets born in the Danzig Province in 1957-1971.


The Bristol quadruplets. Twenty-four year history.


Uniovular quadruplets of Wroclaw.

Uniovular quadruplets of Wroclaw.


The Danzig quintuplets: perinatal complications and first days of life.


Physical development of the Danzig quintuplets in their first year of life.


Psychomotor development of the Danzig quintuplets in their first year of life. A psychological evaluation.


Pituitary gonadotropins and multiple births in Nigeria.


Multiple births in Poland in 1949-1971.

Multiple births in Poland in 1949-1971.


Unexplainable demographic phenomena of multiple births in Hungary.


Multiple births in Southern Moravia.

Multiple births in Southern Moravia.


The Twin Register of Budapest.

The Twin Register of Budapest.


The genetic characteristics of South-Moravian twins.


The genetic and somatopsychic examination of twins born in Budapest in the year 1970.


Maintenance of a low level of sex chromatin in one of uniovular twins.


Studies on karyotypes in children from triplet pregnancies and in their parents.


Obstetrical problems of conjoined twins.


Newborn twins.

Newborn twins.


An attempt to estimate normal values of peripheral blood in twins at the first, third, and sixth day after delivery.


Some parameters of erythrocyte system in newborn twins.


Cardiovascular system in newborns from multiple pregnancy.


Cardiac electrogenesis in twins.

Cardiac electrogenesis in twins.


An autopsy case of meningioma with extracranial remote metastases.


Comparative assay of HCG, HCT and HCS in molar pregnancy. The secretion patterns of human chorionic gonadotropin (HCG), human chorionic somatomammotropin (HCS), and human chorionic thyrotropin (HCT) were studied in 10 women with hydatidiform mole and 30 women in the early stage of normal pregnancy.  Serum levels of the chorionic hormones were determined by radioimmunoassay with the double-antibody method.  In the cases of hydatidiform mole, HCG and HCT levels were considerably higher than values normally obtained during pregnancy, while HCS levels were abnormally low.  HCG and HCT levels did not change 6 hours after molar delivery, though HCS levels rapidly decreased and became undetectable shortly thereafter.  It required 3 weeks for HCG to fall to the level of pituitary luteinizing hormone and 5 days for HCT to become undetectable.  The observed differences are regarded as characteristic findings in hydatidiform mole.  It was concluded that simultaneous assay of HCG, HCT, and HCS is a useful indicator of the completeness of treatment of hydatidiform mole.


Chronic copper poisoning and changes in the central nervous system of sheep.


Lactoferrin and iron absorption in the small intestine.


Coagulation studies in hemolytic uremic syndrome and thrombotic thrombocytopenic purpura.


Adrenergic receptors: isolation and molecular properties.


Apomorphine derivatives and dopaminergic activity.


L-DOPA: chemical modifications and biological evaluation.


Dopamine receptor site sensitivity in hyperthyroid and hypothyroid guinea pigs.


Ocular hysteria, malingering and other bizarre complaints.


Treatment of diabetic optic nerve neovascularization by extensive retinal photocoagulation.


The mutation load in an African population. I. An analysis of consanguineous marriages in Nigeria.


Electrochemical potentials of chloride in distal renal tubule of the rat.


Preventing dental disease in children: An ecological approach.


Capacitation of boar spermatozoa: the influence of post-coital separation of the uterus and fallopian tubes.


Hydatid cysts affecting multiple organs: the first case report from Iran.


Hemangiosarcoma in children: two case repots.


Onchocerciasis.

Onchocerciasis.


Submerged production, purification, and crystallization of acid carboxypeptidase from Penicillium janthinellum IFO-8070. Penicillium janthinellum IFO-8070 produced an acid carboxypeptidase of molecular weight 51,000 in a liquid medium at 25 C. Maximum enzyme concentration was obtained within 3 to 6 days in a medium containing 2% wheat bran, 1% defatted soybean, and 1% KH(2)PO(4); the initial pH was 2 to 4. When submerged aerobic conditions were used, a 51,000-molecular-weight acid carboxypeptidase was produced and no detectable amounts of 160,000-molecular-weight acid carboxypeptidase were produced. Acid carboxypeptidase with a molecular weight of 51,000 was purified 330-fold from koji culture to yield a crystalline protein which was demonstrated by disc electrophoresis to be homogeneous. The purification method included ammonium sulfate fractionation, Amberlite CG-50 chromatography, acetone fractionation, Amberlite CG-50 rechromatography, and concentration in a collodion bag. The specific activity of the enzyme was about three times more than that of the acid carboxypeptidase from Aspergillus saitoi.


Parabiotic chamber for organ cultures: improved model. A modified parabiotic chamber for organ cultures is described. It consists of a modified organ culture dish, glass cover slip, a cylinder of semipermeable membrane, and a stainless-steel mesh filter support. Silicone and agar seals were used. Diffusion occurred rapidly and with consistent rates at 37 C when a ratio of 5:2 reservoir to inner chamber volume was used. The device is simple to construct and assemble and allows for continuous observation while maintaining a large surface area available for diffusion. The volumes of the reservoir, inner chamber, and agar base can be varied, and the chamber may be used with a wide variety of cell and organ culture systems.


Differentiation of staphylococcal and micrococcal proteinases by electrophoresis. The electrophoretic separation of the proteinases produced by staphylococci and micrococci was studied in four buffers. The duration of electrophoresis was based on the migration of a marker dye for a predetermined distance. The migration distances of the enzymes and dye were measured, and enzyme-dye values were calculated. A comparison of enzyme-dye values showed that complete separation of eight serologically different proteinases did not occur in any one buffer; however, in most instances, their relative order of migration was the same in all buffers. Certain strains of Staphylococcus epidermidis produced two proteinases that were different serologically as well as electrophoretically. Staphylococcus aureus strains, on the other hand, produced up to four proteinases that were serologically the same. The proteinases of staphylococci and micrococci can be best characterized by both electrophoretic and serological methods.


Fermentation of feedlot waste filtrate by fungi and streptomycetes. The soluble and dispersed nitrogen and carbon components in the filtrate fraction of cattle feedlot waste are a potential nutrient source from which single-cell protein could be produced for animal feeds. The ability of more than 200 fungi and streptomycetes to grow in this liquid was determined; these included isolates from the waste and associated sources, as well as organisms maintained in the Culture Collection of the Agricultural Research Service in Peoria, Ill. Utilization of waste nutrients was measured by changes in nitrogen content and chemical oxygen demand. Only 20% of the organisms were able to grow appreciably in the filtrate. Of these, dry-weight yields varied from 0.6 to 2.7 g of mycelium per liter; from 21 to 50% of the nitrogen in the filtrates was used during growth, whereas chemical oxygen demand levels diminished from 4 to 60%. In general, streptomycetes isolated from the feedlot used nutrients from the filtrates better than fungi did. Addition of readily available carbon sources such as glucose or whey significantly increased (as much as sixfold) cell yields of selected organisms and promoted better utilization of nitrogen (from two- to threefold); the effect on chemical oxygen demand varied (0 to 33% increase).


Rapid detection of bovine mycoplasma antigens by counterimmunoelectrophoresis. Twelve reference strains of mycoplasma and acholeplasma previously reported to have been recovered from cattle were tested against hyperimmune rabbit serum by counterimmunoelectrophoresis. This technique detected antigen by the formation of precipitin lines with antibody within 1 h and promises to be a useful technique for detecting and identifying mycoplasma isolates in either pure or mixed cultures.


Toxicity of short-chain fatty acids and alcohols towards Cladosporium resinae. Long-chain saturated fatty acids (C(13) to C(18)) and fatty alcohols (C(12) to C(18)) were well utilized by three different soil isolates of Cladosporium resinae as the sole carbon and energy sources in static liquid cultures. Shorter-chain compounds, down to C(5), did not support growth and were in fact toxic towards the fungus growing on glucose. Rapid and considerable potassium efflux, protein leakage, and inhibition of endogenous respiration were observed in the presence of the shorter fatty acids and alcohols. Possible mechanisms and significance of the toxicity are discussed.


Human plasma kallikrein. Purification and preliminary characterization.


Nuclear magnetic resonance and ultraviolet difference spectral studies of the binding properties of turkey egg white lysozyme. Consequences of the replacement of Asp 101 by glycine.


Amino acid sequence of the alanyl peptide from cyanogen bromide cleavage of bovine plasma albumin.


Studies on the mechanism of cell attachment to a substratum with serum in the medium: further evidence supporting a requirement for two biochemically distinct processes.


Formation and characterization of mixed micelles of the nonionic surfactant Triton X-100 with egg, dipalmitoyl, and dimyristoyl phosphatidylcholines.


Retention of calcium by mitochondria isolated from Ehrlich ascites tumor cells.


Comparison of dried milk preparations for babies on sale in 7 European countries. II. Folic acid, vitamin B6, thiamin, riboflavin, and vitamin E.


The missing umbilical artery. I. Prospective study based on a maternity unit.


Comparison of dried milk preparations for babies on sale in 7 European countries. I. Protein, fat, carbohydrate, and inorganic constituents.


Clinical evaluation of Sephadex gel filtration in estimation of bilirubin binding in serum in neonatal jaundice.


Editorial: Operative treatment of hypertrophic subaortic stenosis.


Surgical management of idiopathic hypertrophic subaortic stenosis.


Alcohol ingestion in lactating rats: effects on mothers and offspring. I. Sprague-Dawley lactating female rats were divided into 2 groups.  The control group was fed water and the experimental given a 10% solution of ethanol as its only source of fluid.  All other conditions such as food, housing, and number of suckling pups were identical.  Animals were weighed daily.  After 21 days 'sleeping time' of all off spring was determined following an ip injection of 4g/kg (20% w/v) ethanol.  Blood and brain ethanol concentrations were determined by gas chromatography.  The results showed a depressed growth rate in offspring (38.7 gm as compared with 44.6 gm in controls, p less than .01).  The mean fluid intake was lower (p less than .01) in lactating ethanol treated females.  The mean sleeping time of offspring of ethanol treated females was lower (p less than .05).  The results indicate that suckling animals whose mothers are drinking ethanol have significantly lower growth rates and that a tolerance to ethanol in the sucklings can occur.


The differential role of the caudate nucleus and the linear raphe nucleus in the initiation and the maintenance of morphine-induced behaviour in cats.


Partial restoration by a neuroleptic (spiramide) of items of grooming behaviour suppressed by amphetamine.


Total gastrectomy with preservation of the hepatic and celiac vagi.


Cerebral metastasis of alveolar soft-part sarcoma. Report of a case of long postoperative survival.


Adenomyomatosis of the gallbladder.

Adenomyomatosis of the gallbladder.


Regulation of amino acid and glucose dissimilation in so-called ammonifiers and in other soil microorganisms.


Some aspects of the regulation of the production of extracellular proteolytic enzymes by a marine bacterium.


Sexual problems of heroin addicts.

Sexual problems of heroin addicts.


Ethanol, methamphetamine, pentobarbital, morphine, and monkey social behavior.


Homologous interference in Aedes aegypti cell cultures infected with Sindbis virus.


The use of trypsin-treated human group O erythrocytes in rubella hemagglutination-inhibition test.


Replication of measles virus in dolphin kidney cells.


Multiplication of different Newcastle disease virus strains in chicken brain.


Electron microscopic studies on frog virus 3 infection in HeLa cells at permissive and non-permissive temperatures.


Serological classification of two mouse adenoviruses.


Properties of an RNA polymerase complex detected in influenza virus-infected cells.


An abattoir study of the genital pathology of cows in Northern Australia.


Synthesis and maturation of ribosomal ribonucleic acids in isolated HeLa cell nuclei. A tracer study on the topology of the 45S precursor of ribosomal ribonucleic acids. The synthesis and processing of RNA by isolated HeLa cell nuclei was studied at low ionic strength in the presence of alpha-amanitin. The RNA polymerase reaction, with endogenous template and enzyme, rapidly reaches a plateau dependent on the amount of nuclei. Evidence is presented that incorporation of [(3)H]UMP proceeds only in growing RNA chains, whereas initiation of new RNA chains is arrested. The product formed contains all the main components of the 45S pre-rRNA (precursor of rRNA) maturation pathway (45S, 32S and 20S pre-rRNA; 28S and 18S rRNA). Most of the labelled material is in the mature rRNA components and their immediate precursors, even at very short times of incubation (2min). Small, but definite, 5S and 4S RNA peaks are also observed. At shorter incubation times a substantial amount of [(3)H]UMP is incorporated into RNA molecules in the 24S and 10-16S zones. This RNA material is considered to represent the non-conserved segments of 45S pre-rRNA in the process of nucleolytic degradation. A model for the tracer study of the topology of 45S pre-rRNA, on arrest of rRNA initiation, is discussed. The experimental evidence obtained supports the following structure of 45S pre-rRNA: 5'-end-28S rRNA unit-18S rRNA unit-nonconserved segment-3'-end.


Homospecific activity, an immunologic index on enzyme homogeneity; changes during the purification of dopamine-beta-hydroxylase.


The metabolism  of macromolecules during the differentiation of Myxamoebae of the cellular slime mould Dictyostelium discoideum containing different amounts of glycogen. 1. Methods of obtaining myxamoebae of Dictyostelium discoideum strain Ax-2 (ATCC 24397) with glycogen contents in the range 0.05-5mg of glycogen/10(8) cells are described. The changes in cellular glycogen, protein and RNA content during the differentiation of such myxamoebae were determined. 2. Myxamoebal glycogen is not conserved during differentiation and gluconeogenesis may occur even in cells that contain a large amount of glycogen initially. 3. There is a marked net loss of cellular protein and RNA during differentiation and associated with this there are also marked decreases in the sizes of the intracellular pools of amino acids, acid-soluble proteins and pentose-containing materials. 4. During the early stages of development some protein and pentose(s) are excreted, but this cannot account for the decreased cellular content of protein and RNA. 5. There is a linear rate of production of NH(3) during development, and oxidation appears to be the fate of the major portion of the degraded protein and RNA. 6. However, provision of an alternative metabolizable energy source (glycogen) has little effect on the rate or extent of protein or RNA breakdown or on the changes in the sizes of the intracellular pools of amino acids, acid-soluble proteins and pentose-containing materials. 7. It is concluded that during development there is a requirement for the destruction of specific RNA and protein molecules for reasons other than the provision of oxidizable substrates. 8. The kinetic model of Wright et al. (1968) is discussed in relation to these changes in macromolecular content.


The apo-holo hybrid of cytosolic aspartate aminotransferase, preparation and studies on subunit interactions.


The effect of disulphide bond reduction on cholinoreceptors in cultured skeletal muscle.


Amphetamine-induced changes in striatal dopamine and acetylcholine levels and relationship to rotation (circling behavior) in rats.


Effect of context on teaching of psychology to medical students.


Specificity and sites of calcium ion interactions with elastin.


A simple method for purification of acetylcholinesterase from human erythrocyte membranes.


Effect of isolation on some behavioral characteristics in three strains of mice.


Demonstration of a lipolytic activity in human milk that inhibits the glucuro-conjugation of bilirubin.


Optical and electro-optical properties of the complexes of dibutylproflavine with DNA and nucleohistone.


Preparation of an immobilized two-enzyme system, Beta-amylase--pullulanase, to an acrylic copolymer for the conversion of starch to maltose. III. Process kinetic studies on continuous reactors.


Distribution and action of fluacizine during prolonged administration.


Antigen-reactive cells in the spleen of mice with methylcholanthrene-induced sarcoma.


Glycogen content in skeletal muscles and liver of rabbits in the antenatal and neonatal periods.


Ultrastructure of lymphatic capillaries of the human myocardium in mitral stenosis.


A rapid and simple radioassay for thymine 7-hydroxylase.


Changes in the ultrastructure of the kinetochore during mitosis.


Preconstruction of density gradients in cells of the analytical ultracentrifuge.


The effects of microiontophoretically applied morphine and transmitter substances in rats during chronic treatment and after withdrawl from morphine. The effects of microiontophoretically applied acetylcholine, noradrenaline, 5-hydroxytryptamine and morphine were studied on single brain stem neurones of rats during chronic morphine pretreatment and 24 h after its withdrawal. No significant changes were observed in the initial spontaneous neuronal firing rate or in the qualitative or quantitative effects of acetylcholine, noradrenaline or 5-hydroxytryptamine. However, in chronically treated animals there was a significant decrease in the number of neurones excited by morphine or showing tachyphylaxis to morphine on repeated microiontophoretic applications.We suggest that some of the cellular central nervous system changes which occur during chronic morphine treatment are reflected by the decrease in sensitivity of neurones to morphine excitation.


Effects of catecholamine synthesis inhibition on ethanol-induced withdrawal symptoms in mice. alpha-Methyl-p-tyrosine, a catecholamine synthesis inhibitor, was studied to determine its effects against ethanol-induced withdrawal symptoms in mice. Signifilcant (P < 0.001) potentiation of the withdrawal convulsion score induced by ethanol vapour exposure for three days was observed in mice. The synergistic effect was not due to alteration of ethanol metabolism. These results indicate that reductions in catecholamines (dopamine and noradrenaline) augment seizure activity induced by subchronic exposure to ethanol.


Proceedings: An altered metabolism of dopamine in the striatal tissue of mice made aggressive by isolation.


The influence of haemoglobin and platelet levels on the results of arterial surgery.


Editorial: Pregnancy without a uterus.

Editorial: Pregnancy without a uterus.


Letter:Peripatetic Psychopenal disorder.


Letter: Agoraphobia.

Letter: Agoraphobia.


Opiate agonist-antagonist interaction at cortical neurones of naive and tolerant/dependent rats.


Evaluating the performance and sulphur amino acid requirements of normal and midget hens.


Butane-oxidation products as substrates for yeast growth.


Effect of propagule size on the in vitro production of polygalacturonase and cellulase by Rhizoctonia solani.


The ultrastructure of the yolk nucleus during early cleavage of Nassarius reticulatus L. (Gastropoda, Prosobranchia).


Epitheliomuscular cells in Lingula unguis (Brachiopoda) and Branchiostoma lanceolatum (Acrania).


Transformations of hypothalamic arcuate neurons. I. Changes associated with stages of the estrous cycle.


Localization of microfilaments in prolactin cells of the rat anterior pituitary gland.


Auditory acuity in rural Africans: a selected study.


Cytoplasmic giant RNA in sea urchin embryos. I. Proof that it is not derived from artifactual nuclear leakage.


The determination of RNA homogeneity by molecular hybridization.


Pyrogallol potentiates acetaldehyde blood levels during ethanol oxidation in rats.


Modified radioimmunoassay of prostaglandin F 2 alpha using commercially available reagents.


Occult breast cancer.

Occult breast cancer.


Antifertility effects of PGE2 and PGF2alpha.


The heritability of serum lipoprotein and lipid concentrations. A twin study.


Cytogenetic analysis of Neotomodon alstoni alstoni.


Genetical and cytological changes induced by cowdung in Tradescantia clone O2.


Effects of ethidium bromide on mitosis and chromosomes: a possible material basis for chromosome stickiness.


Influence of calf serum on the transport of 2-aminoisobutyric acid in embryonic rat fibroblasts.


Studies on phenylalanine-specific transfer ribonucleic acid from chick embryos.


Studies of glutamate dehydrogenase. The influence of salts and organic solvents on the thermodynamic parameters of the association-dissociation equilibrium of beef-liver glutamate dehydrogenase.


Effect of DNA polymerase on nuclei from different phases of cell cycle.


RBE and OER values as a function of neutron energy.


The response of Chinese hamster cells to 252californium neutrons and 14 MeV neutrons.


Biological effects of 252Cf neutrons.

Biological effects of 252Cf neutrons.


The importance of change in biological response with depth in tissue for collimated neutron beams-further experimental verification.


Influence of hemicholinium (HC-3) on morphine analgesia, tolerance, physical dependence and on brain acetylcholine.


Chronic amphetamine treatment: vast individual differences in performing a learned response.


Effect of nicotine on response to frustrative non-reward in the rat.


Identification of prolactin in cerebrospinal fluid.


Progesterone in peripheral plasma and tissues during pregnancy in the rat.


Effect of methylendioxyphenyl synergists on metabolism of carbaryl by Aspergillus terreus.


Rhythm: systematized chance-taking.

Rhythm: systematized chance-taking. The variations of the rhythm method of contraception and its inadequacy as a reliable method are discussed.  Studies of women following the calendar method have shown a failure rate of 30 pregnancies per 100 women-years of use.  Failure rates with the basal body temperature method have been observed to be lower than when the calendar method and basal body temperature method are combined (6.6 and 19.3 per 100 woman-years).  Sufficient data does not yet exist to evaluate the cervical mucus method.  The failure rates are higher than those found with oral contraceptives, IUDS, and occlusive methods.  The development of methods to determine the post ovulatory phase of the menstrual cycle would enhance the rhythm method.  It is concluded that methods which attempt to predict the ovulatory phase are not effective methods of birth control.


Cycloheximide induced in vivo modification of ornithine decarboxylase in Physarum polycephalum.


The thermal transition of 'psi' DNA monitored by circular dichroism.


The titration of rhodanese with substrates.


Dopamine beta-hydroxylase: evidence against a ping-pong mechanism.


Inhibition of DNA-dependent DNA-polymerase by ethidium bromide and 3,8-diamino-6-ethyl-5-methylphenanthridinium bromide.


X-ray crystallographic study of binding of cobalt ion to hen egg-white lysozyme.


"Poly C" synthesis and CDP-diglyceride formation by isolated brain nuclei.