Microfiltration method for quantitative study of fibrous particles in biological specimens. Counting coated and uncoated inorganic fibers in sputum has been used to investigate the level of environmental or occupational asbestos exposure and the concentration of fibrous dusts in human lung. Inorganic fibers in sputum were counted by light microscopy after chemical digestion and microfiltration processing. The same method was used for processing gastric juice and lung tissue. There were no ferruginous bodies (FB) in sputum from 49 patients without any asbestos exposure. The study of sputum from 125 patients with various asbestos exposure pointed out a high correlation between the number of FB in sputum and the level of asbestos exposure. These 125 patients were classified into three groups according to the type of their asbestos occupational hazard: group I, raw asbestos workers; group II, workers manufacturing asbestos products; group III, workers with mixed industrial dust exposure. For these three groups, the mean number of FB in sputum was 100, 10, and 1, respectively. The comparison of the FB content of sputum and lung parenchyma showed the absence of FB in sputum when the concentration of FB in lung parenchyma was under 1000/cm(3) of lung parenchyma; above this concentration the number of FB in sputum was in good correlation with fiber concentration in lung parenchyma. A preliminary study with the use of gastric juice showed that gastric juice is a less sensitive sample for evaluating fiber concentration in lung. The microfiltration method for the counting of uncoated fibers gave results as accurate as those in the centrifugation method.


Aluminum in the environment and human health. The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses are presented. It is concluded that absorption and retention or accumulation of Al in humans occurs at lower levels of intake than had been assumed formerly. However, levels of 5 to 50 times the normal daily intake do not appear to interfere with other metabolic processes. The adverse effects of Al reported in the more recent years resulted from the inhalation or ingestion of Al in concentrations many times greater than the amounts present under normal circumstances. As in the past, there is still no need for concern by the public or producers of Al or its products concerning hazards to human health derived from well established and extensively used products.


Ferric oxyhydroxide microparticles in water. Mineralogy and specific surface area are major controls on the stabilities of ferric oxyhydroxide microparticles in natural waters. The thermodynamic stabilities of ferric oxyhydroxides, as described by the activity product in solution pK = -log [Fe(3+)] [OH(-)](3) range from pK = 37.1 for freshly precipitated amorphous oxyhydroxide to pK = 44.2 for well crystallized goethite. The sizes of suspended oxyhydroxide particles in natural waters range from less than 0.01 mum to greater than 5 mum. Oxyhydroxides precipitated in the laboratory from solutions simulating high-iron natural waters are needlelike or lathlike in shape and have mean thicknesses as small as 60 A. Large specific surface areas resulting from the small sizes of ferric oxyhydroxide particles cause increased solubilities and thus decreased pK values. Specific surface areas of 40-170 m(2)/g determined for laboratory precipitates gave computed decreases in pK of 0.4 to 1.6 units.


Analysis of amphibole asbestiform fibers in municipal water supplies. Details are given of the techniques used in the analysis of asbestiform fibers in the water systems of Duluth, Minnesota and other cities. Photographic electron diffraction and electron microprobe analyses indicated that the concentration of verified amphibole mineral fibers ranged from 20 x 10(6) to 75 x 10(6) fibers/l. Approximately 50-60% of the fibers were in the cummingtonite-grunerite series and 20% were in the actinolite-tremolite series. About 5% were chemically identical with amosite. A wide variety of analytical techniques must be employed for unique identification of the mineral species present in water systems.


Deep sea sedimentation.

Deep sea sedimentation. An important problem in the study of microparticles in the marine environment, suspended in the water column or deposited as sediment on the ocean bottom, is the determination of provenance of the microparticles-where did they come from and by what processes were they transported to the sampling location? Two techniques of possible interest to those concerned with tracing the origins and dispersion paths of asbestos particles are described. One utilizes variations in the naturally occurring rubidium-strontium isotope system and is used to characterize a bulk sample, i.e., a large number of particles. The other utilizes scanning electron microscopy to observe variations in surface texture of individual grains which, in the case of quartz particles in the natural environment, can be related to the transport processes to which they have been subjected.


Measurement of pollution history.

Measurement of pollution history.


Analysis for asbestos in environmental samples.


The ingestion of asbestos fibers.

The ingestion of asbestos fibers. Feeding of baboons with crocidolite showed small numbers of asbestos needles 0.5-1 mum in ashed tissue of the gut wall, which probably came from iron-containing macrophages. It is suggested that pleural plaques and hyaline nodules in the peritoneum represent a hypersensitivity reaction to ferritin protein coating on asbestos fibers. In South Africa only a few peritoneal mesotheliomas come from the asbestos areas, and the incidence of gastrointestinal carcinomas is no greater than normal. Intrapleural and intraperitoneal injection produces unrealistic situations. Calcium salts are deposited on asbestos cement pipes from hard water and organic material from soft water. It is difficult to envisage asbestos contamination of the water so reticulated.


Lymphohematogenous spread of asbestos.

Lymphohematogenous spread of asbestos.


Passage of particles through the wall of the gastrointestinal tract. In the normal process of digestion, not only substances in solution are absorbed. Solid, undissolved particles in macrocorpuscular form, are "kneaded" into the mucosa during their passage through the digestive tract. These particles in the micrometer size range pass between the epithelial cells into the subepithelial layer. From here they are transmitted both by the lymph vessels and by the mesenteric veins into the circulation, where they remain for a considerable time. This phenomenon, termed persorption, was investigated in detail.


Asbestos fibers in the colonic wall.

Asbestos fibers in the colonic wall.


Inorganic particles in human tissues and their association with neoplastic disease. An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encountered in the lung tissues from the same individuals. Ingestion of asbestos fiber in some environmental instances may approach in magnitude the amount resulting from occupational exposure. Disease factors are discussed.


Interaction of asbestos with alveolar cells. A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue. The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers. The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes. The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and rephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease.


Response of cell cultures to asbestos fibers. The reaction of macrophages to asbestos and glass fibers was studied by light and by electron microscopy. Measurements were made of LDH release, staining with erythrosine B, and lactate production. Size and shape of asbestos fibers were found to have more effect than the physicochemical properties of the surface. Long fibers resulted in a protracted pathogenic but no acute cytotoxic effect.


Penetration of cells by asbestos fibers. Studies on the behavior of asbestos fibers within tissues have shown that the only cells that regularly contain asbestos are macrophages and their derivatives. However, these cells actively incorporate the asbestos fibers by the process of phagocytosis, and there is little evidence of direct penetration. Examination of the gut lining after prolonged asbestos ingestion has shown no evidence of dust penetration either through or between the epithelial cells. The structure and arrangement of these cells is discussed, and it is suggested that they are exceptionally well adapted to prevent penetration by any solid material.


Correlation between the tissue response and asbestos fiber content. Asbestos fiber concentration increases in proportion to the degree of pulmonary fibrosis as far as the moderate grade. No such correlation occurs with severe asbestosis, nor with the morphological form which the fibrosis assumes, and here secondary factors may be concerned. Electron microscopy suggests that optically visible fibers constitute a reasonably constant proportion of the total irrespective of the pathological reaction. Light microscopy may thus afford a guide to the total asbestos concentration. Finally, the development of mesothelioma, whether of the pleura or the peritoneum, appears to be unrelated to the concentration of coated or uncoated asbestos fibers residing in the lung.


Cytotoxicity of heated chrysotile.

Cytotoxicity of heated chrysotile. Cytotoxicity and hemolysis were studied in chrysotile and quartz. The biological activity of the surface seemed to be different between chrysotile and quartz. Quartz lost its cytotoxicity on heating over about 500 degrees C. However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800 degrees C, compared with the original unheated specimens. The mice injected intraperitoneally with minerals heated in this temperature range generally died within 48 hr after injection, while those injected with untreated chrysotile or chrysotile heated in the other heat ranges did not. The products in this range were highly disorded materials. It was assumed that the change of biological effects resulting from heat treatment may be related to the disordered state of chrysotile in the process of transformation into forsterite. The relationship between chemical character and cytotoxicity of the heated chrysotile specimens was also studied.


Immunological reflections on asbestos.

Immunological reflections on asbestos.


Digestive system cancer among persons subjected to occupational inhalation of asbestos particles: a literature review with emphasis on dose response. Human data show a dose-response relationship between industrial exposure to asbestos and later development of cancer of the bronchus and lung and of cancer of the digestive tract. The data do not provide much evidence for a threshold or for the existence of a clearly "safe" level of exposure. Good dose-response data, with quantitative estimates of dose are uncommon; however, in all the literature reviewed only one paper did not support the conclusion that increased exposure to inhaled asbestos particles leads to increased digestive system cancer.


Peritoneal mesothelioma.

Peritoneal mesothelioma.


Epidemiology of gastrointestinal cancer. Some 99,000 new cases of cancer of the colon are expected next year, an incidence rate higher than that for both cancer of the lung and cancer of the breast. Evidence from geographic pathology suggests that some environmental factors play a strong role in its etiology. Data obtained in the 1959 survey of one million people by the American Cancer Society and followed since, has failed to show correlation with any of the large number of factors listed. It is suggested that the etiology is one of multiple factors. The synergistic effect of exposure to asbestos and cigarette smoking in the production of bronchogenic carcinoma is demonstrated by data on cohorts of insulation workers. There was also a modest increase in the number of deaths from gastrointestinal cancer in asbestos workers, but smoking did not seem to act in synergistic fashion at that site, except perhaps in the esophagus. Deaths from cancer occurred almost entirely after a period of 20 years or more from initial exposure. The death rate from cancer tended to increase with duration of exposure, but a distinct rise over the expected was seen in those who had been exposed less than one year to amosite dust.


Use of experimental animals.

Use of experimental animals.


Effects of ingested chrysotile on DNA synthesis in the gastrointestinal tract and liver of the rat. The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicated that 2 weeks after a 5 mg/kg dose of chrysotile, DNA synthesis was increased in the small intestine and colon and reduced in the liver; synthesis was reduced in the small intestine 2 weeks after a 500 mg/kg dose. Following a 100 mg/kg dose of chrysotile, a transient increase in DNA synthesis was noted in the stomach and small intestine at 1 and 7 days, respectively, besides increased synthesis in the colon from 28 to 63 days. These data suggest that asbestos penetrates the gastrointestinal mucosa and influences regulation of DNA synthesis in the gastrointestinal tract.


Multiple factors in carcinogenesis.

Multiple factors in carcinogenesis.


Asbestos in the workplace and the community. Information developed by Newhouse in a survey of an asbestos factory in London suggests that the risk of mesothelial tumors is strongly related to both the degree and the length of exposure to asbestos dust.


Research perspectives concerning asbestos minerals and their effects on biological systems. The interaction of asbestos minerals with biological materials is under intensive investigation throughout the world today. Physical scientists should be responsible for the selection of fibers, and their varietal types, for biological studies; they should characterize these experimental materials physically and chemically to the level of sophistication which currently exists in their fields; they should develop definitive assay methods to monitor changes in such characteristics after biological residence; they should actively participate in the formulation of theories or mechanisms of particle interaction in biological systems.Physical scientists should begin the characterization of minerals in the environment and the determination of ambient fiber levels in air and potable water supplies. Such characterization of the environment requires standardized instrumentation and preparation techniques. Acquisition of data in numbers large enough to achieve statistical significance requires the development of automated counting strategies. Instrumentation and software have yet to be developed. The training of physical scientists in environmental areas is lagging behind current national needs and must be accelerated.


The subject of continuous vigilance.

The subject of continuous vigilance. Asbestos disease in the occupational setting has been documented since the beginning of this century. Modern usage of asbestos fiber has brought with it concomitant and widespread contamination of the environment. The need to control asbestos is required in the forms of legislation and surveillance, to prevent the spread of asbestos disease into the general population.


Detection and identification of asbestos by microscopical dispersion staining. Asbestos fibers as small as 1 mum in diameter can be uniquely identified by light microscopy by employing dispersion staining methods. The technique described herein involves suspension of fibers in liquids of known refractive indices and observation of color display by means of a dispersion staining objective. Wavelengths or indices of refraction may be determined at right angles to and parallel to fiber axes. This method is rapid and sensitive for identification purposes.


Electron microscopical investigation of asbestos fibers. Examination of asbestos fibers by electron microscopical techniques enables the observer to distinguish among the fiber types by morphological and structural characteristics. Chrysotile asbestos fibers are composed of bundles of fibrils. Fibers are often curvilinear with splayed ends. Individual fibrils consist of a central capillary defined by an electron dense crystalline wall. With increasing time of electron bombardment, the capillary wall decreases in thickness, deforms, and is encapsulated in an electron translucent material. The change in electron opacity is considered to be a product of structural disruption brought about by dehydroxylation due to electron radiation. A well recognized sequential deformation pattern may be used for identification purposes.Amphibole fibers tend to be straight, splintery, and electron-opaque, although curved fibers are occasionally observed. Diffraction contrast figures are visible as dark bands moving parallel and at right angles to the fiber axis. Crocidolite forms the shortest and thinnest fibers, followed in size by amosite and anthophyllite. Size distribution characteristics of the amphibole fiber types are different. The selected area electron diffraction pattern for chrysotile is unique. Reflections range in forms from streaked to arcuate. Reflection intensity and shape are related to the degree of openness of the fiber bundle and the extent of physical degradation of the fiber. The amphibole asbestos fibers possess diffraction patterns having similar characteristics prohibiting individual identification. Microchemical analysis is required for identification in such cases.A discussion of the industrial hygiene threshold limit values for ampliphibole asbestos fibers is presented. The discussion is based on their differing size distribution characteristics.


Elemental analysis of asbestos fibers by means of electron probe techniques. The identification and characterization of microparticles has become an important field of study in recent years due to their presence in the environment and association with pathogenesis. Asbestos fibers have been intensively studied for these reasons. Since conventional microscopy has not provided unique identification of these materials, electron probe microanalysis, which yields chemical data, has been utilized in conjunction with other techniques to provide the necessary answers.The options now available to undertake electron probe analysis are discussed with relation to their utilization for microparticle analyses. Two types of electron sources are available, thermionic and field emission. The x-ray spectroscopy requires the use of either wavelength-dispersive focussing crystal spectrometers or an energy-dispersive Si(Li) x-ray detector. Data are presented to demonstrate the feasibility of asbestos identification by using modified raw data obtained with a scanning electron microscope and energy-dispersive x-ray spectrometer. Further, the extension of the technique to other microparticle identification problems is discussed.


Identification and quantitation of asbestos in talc. The currently used analytical methods for identification, characterization and quantitation of asbestos fiber in consumer talcum products include polarized light microscopy, x-ray diffraction analysis, transmission electron microscopy with selected area electron diffraction and electron microprobe techniques. Light microscope methods have severe limitations imposed by the ultimate size resolution of the light-optical system. Small particles go unresolved; those marginally resolved may possess optical properties different from those properties cited in the literature; most optical properties, e.g., indices of refraction, are difficult to measure on small particles. In addition to these difficulties, talc fibers often possess optical properties different from those of talc plates, which further confound analysis. Light microscopy is recommended for use only as a preliminary tool on limited, large-sized, samples. Transmission electron microscopy is a good standard technique for visualization of contaminant asbestos fibers. Together with selected area electron diffraction, talc fibers may be easily differentiated from amphibole asbestos fibers on the basis of both morphological and structural characterization. Chrysotile fibers are easily distinguished on this basis as well. The amphibole asbestos minerals require chemical characterization to differentiate among the different fiber types. Probe analysis is mandatory for such fibers. The major drawbacks to electron beam instrumentation for the mineralogical characterization of talcum products are the time and effort required for data acquisition. These techniques do not lend themselves to routine study.X-ray diffraction analysis, utilizing the step-scan method, offers a relatively rapid, quantitative technique for gross fiber analysis. Based on comparison with standard specimens the fiber content of talcs may be quantitatively determined. It is essential to employ a specimen preparation technique which yields homogeneously dispersed particles. Tremolite may be determined at levels as low as 0.10% by weight, chrysotile 0.25%, and anthophyllite at 2.0% by weight occurrence in talc. The variance of these values depends upon many factors, including the mass absorption coefficient of the fiber types as compared to talc and selected diagnostic reflections and their relative intensities. Each of the above techniques is described in detail. A method for routine analysis of consumer talcum products is suggested.


Electron microscope identification of mesosomes in some water strains of Leptospira by reduction of tetrazolium chloride to formazans. Rounded granules protruding from the external surface of some water Leptospira strains and considered as mesosomes were studied by electron microscope and by means of the intravital reduction of tetrazolium chloride. Satisfactory results were obtained with two of the strains studied. It appears that neither the culture medium nor the age of the culture have any influence on the unusual position of the mesosomes.


Ultrastructure of native collagen.

Ultrastructure of native collagen. Native collagen fibrils, mechanically detached either from leg tendon of rabbits or from tail tendon or aortic adventitia of adult rats were observed at the electron microscope by various technical methods. The density patterns recorded along and across integer fibrils, laid down on ultrathin C films, show that the density ratio of the light to the dense bands is much higher than that expected from the generally accepted quarter-stagger arrangement of collagen unities. Swollen fibrils show long filaments, about 50 A thick, reasonably identified with their building unities. The characteristic collagen banding of about 640 A periodicity, never exhibited by single filaments, is already present in groups of very few filaments (order of two or three). Partially disrupted fibrils suggest that the building filaments may be assembled in a monolayer, having the form of a long ribbon, spirally wound around the longitudinal axis of the integer fibril.


Contribution to the standardisation of a gas chromatographic method for the analysis of an oestrogenic and progestational combination. An experimental procedure is described in order to standardize a gaschromatographic method proposed for a collaborative study organised by the F.I.P. Committee for Laboratories and Official Drug Control Services, on the analysis of some oestro-progestinic formulations. The assayed combination was a standard mixture of lynestrenol, mestranol and d, 1-alpha-tocopherol: testosterone was included as internal standard; two combinations, differing only in the internal standard content as specified in the text, were used. The variability of the instrumental factor was investigated performing some sets of single experiments, each consisting of 5 successive injections of the same standard mixture, on the same day. For each single experiment and for each substance the mean value Rm of the ratios R (R=area of the peak for compound cpi/area of the peak of the internal standard) was estimated with its relative standard deviation (% s.d.). For each set of experiments the % s.d. values were elaborated, following the Bartlett test, in order to obtain the sigma intra % value for each set, as a measure of the instrumental factor. An experimental evidence was observed for the relationship existing between the instrumental factor value (sigma intra %) and the internal standard content, in the operating conditions fixed for the present gas chromatographic analysis, a lowering of the instrumental factor beeing observed with the higher level of testosterone content (internal standard) in the mixture.


Audiospectral analysis in lie detection.


Information seeking in a multistage betting game.


Editorial: Pulmonary oxygen toxicity.

Editorial: Pulmonary oxygen toxicity.


Tracheal smooth muscle relaxant effect of ketamine.


The effect of change in cardiac output on intrapulmonary shunting.


Acid-base changes in cerebrospinal fluid and blood, and blood volume changes following prolonged hyperventilation in man.


Acupuncture analgesia. Report of 100 experiments.


Blood viscosity during anaesthesia with halothane, cyclopropane, thiopentone and ketamine.


Postoperative vomiting after paediatric adenotonsillectomy. A survey of incidence following differing pre- and postoperative drugs.


Pentazocine and diazepam analgesia for minor gynaecological operations.


Sickle-cell trait. A report of a postoperative neurological complication.


Lithium: an anaesthetic risk.

Lithium: an anaesthetic risk.


Introduction: the interferon system.

Introduction: the interferon system.


Choice, treatment, and storage of sera for the growth of specialized cells.


Bacteriophages and interferon.

Bacteriophages and interferon.


The choice of a cell substrate for preparation of human interferon.


Mass production of human interferon in diploid cells.


Mass production and some characteristics of human interferon from diploid cells.


Human leucocyte interferon: properties and purification.


Studies on antiviral and antitumor effects of human leukocyte interferon in vitro and in vivo.


Translation inhibition factor induced by interferon.


Interferon: its expectations for the future.


Pharmacological vs. clinical physiognomy of neuroleptics, with special reference to their sedative and antipsychotic effects.


Biochemical vs clinical physiognomy of neuroleptics, with special reference to their antimanic effect.


Clinical physiognomy of chlorprothixene and clopentixol.


Clinical physiognomy of flupentixol.

Clinical physiognomy of flupentixol.


Ataraxic and antimanic effects of thioxanthenes.


Antiautistic effect of flupentixol.

Antiautistic effect of flupentixol.


Clinical and electoencephalographical studies of the thioxanthenes.


Pharmacokinetics of flupentixol decanoate.


The Liege physiognomy of neuroleptics, with special reference to thioxanthenes.


Saccadic suppression as visual masking effect.


Slow-wave neuronal activity induced by interoceptive stimuli.


Auditory evoked potentials of the human brain on choice and pseudo-choice tasks.


Inner-dynamics of alpha-waves in pupils studying different school subjects by the suggestopaedic system.


Spatial synchronization of the ongoing bioelectrical activity of the vegetative nerves and brain formations.


Functional significance of stimuli coming from the midbrain on the hypothalamic neurosecretory system.


Efferent influences of the limbic cortex on the activity of cardiovascular and digestive systems.


Evaluation of the image motion parameters (speed and direction) by the rabbit visual cortex cells.


Investigations about high rate flicker visual evoked cortical potentials by humans.


The effect of nerve growth factor in the early stages of nerve tissue formation.


Effects of some antagonists of the inhibitory transmitters on the bioelectric activity of the retinal cells.


Clinical trials of hycanthone in schistosomiasis mansoni in St. Lucia.


Observations on the use of hycanthone in a split dosage in the treatment of Schistosomiasis mansoni.


Renographic studies in vesical schistosomiasis in children.


[Antibacterial activity in vitro and in vivo of a new kanamycin: BBK-8].


New synthetic chemical compounds with expected schistosomicidal activity. Part III. Synthesis of xanthone analogue via stobbe condensation.


Control of snail hosts of bilharziasis in Egypt. I. Effect of triphenyltin hydroxide (Du-Ter) on aerobic oxidation of the snails Biomphalaria alexandrina and Bulinus truncatus.


Effect of some pesticides on the snails intermediate hosts of schistosomiasis in Egypt.


[Mechanisms of antibiotic resistance in Staphylococcus aureus].


A trial of the suppression of infection of Bulinus snails during ambilhar (niridazole) therapy of bilharziasis.


A contribution to the molluscicidal activity of Canna indica L. family cannaceae as a method for control of schistosoma.


Immunoglobins in schistosomiasis.

Immunoglobins in schistosomiasis.


Closed chest injuries in mining practice.


Monogenean and copepod parasites of fishes from the Smoky Hill River, Ellis Country, Kansas.


Intravenous regional anaesthesia method.


Some diagnostic and therapeutic mistakes in mining practice.


Chromosomes of the yellow-faced pocket gopher, Pappogeomys castanops, in Kansas.


A superficial survey of lung pathology.

A superficial survey of lung pathology.


Calcium ions: their ligands and their functions.


Tendon injuries.

Tendon injuries.


Ureteric injury complicating a fractured pelvis.


A case of ptosis.

A case of ptosis.


"Mental" symptoms in organic disease.

"Mental" symptoms in organic disease.


The electrochemical behaviour of DNA at electrically charged interfaces.


Limit-cycles in enzyme-systems with nonlinear negative feedback.


Lutein-cholorophyll-alpha energy transfer in detergent micelles.


Perspectives in immunotherapy of lung cancer.


Epileptic sensitization. A study of "secondary" epileptiform discharges and the influence upon them of acute cortico-cortical and interhemispheral disconnection in animals and in man.


Intrinsic and extrinsic inhibitory mechanisms of convulsive activity.


Red nucleus multineuronal activity during the propagation and extinction of tonic-clonic generalized seizures.


A study of chronic cerebellar stimulation in disorders of sensory communication in the central nervous system.


Polygraphic analysis of all night sleep in patients submitted to chronic stimulation of the cerebellum.


The rat supraoptic-neurohypophyseal system and behavior: role of vasopressin in memory processes.


The role of tissue culture in obstetrics and gynecology.


Glial types of the ventral nerve cord of the earthworm "Eisenia foetida" L. (Sav.). an electron microscopical study.


The problem of genetic diversity.

The problem of genetic diversity.


Famine in Ethiopia.

Famine in Ethiopia.


Studies on the molluscicidal properties of endod (Phytolacca dodecandra): II. Comparative toxicity of various molluscicides to fish and snails.


Studies on the molluscicidal properties of endod (Phytolacca dodecandra). III. Stability and potency under different environmental conditions.


Management of cardiac disease in a paediatric cardiology clinic.


Mineral content of bone. X-ray study in Ethiopians.


Human trypanosomiasis in Ethiopia: investigations in Pinybago village and the surrounding area.


Presidential address at the 10th Annual Conference of the Ethiopian Medical Association, May 30, 1974.


Insect cells: colony formation and cloning in agar medium.


Cell identification in primary cell cultures from skin.


Hydrocarbon-metabolizing activity of various mammalian cells in culture.


Control of 3T3 cell proliferation by calcium.


Nutritional requirements of primary cultures. a neglected problem of modern biology.


How long can one safely work with cell lines?


Side effects of amphotericin B-deoxycholate (fungizone) and nystatin in chick cells in culture.


Method fof maintaining large explants or mature mixed tissue in organ culture: molar tooth and supporting structures from the mouse.


Pancreatic enzyme requirements for the dissociation of rat hearts for culture.


New cell line derived from a human chondrosarcoma.


Modulation of alkaline phosphatase activity in KB cells by hyperosmolality and prednisolone: effect on enzyme inhibition by phosphate.


Studies on a serum substitute for mammalian cells in culture. 2. Analyses of fractionated peptone dialysate and the use of glycine peptides.


Regeneration of tobacco and petunia plants from protoplasts and culture of corn protoplasts.


Establishment of epithelial cell line MDA-MB-157 from metastatic pleural effusion of human breast carcinoma.


Reanimation of cultured mamalian myocardial cells during multiple cycles of trypsinization-freezing-thawing.


Supplement to a survey of commercially available tissue culture media (1970).


Effects of pregnenolone, cyanoketone, and equilenin on the human malignant trophoblast in vitro.


Advances in the treatment of cancer in children.


The diagnosis of cancer in children.

The diagnosis of cancer in children.


The place of combination treatment.

The place of combination treatment.


Supportive care of the child with cancer and his family.


Typhoid-a fresh look at the clinical picture and treatment.


Surgery and radiotherapy in breast cancer.


The earlier detection of breast cancer.

The earlier detection of breast cancer.


Classification of extent of disease in breast cancer.


Role of mastectomy in breast cancer.

Role of mastectomy in breast cancer.


Lung cancer:1974.

Lung cancer:1974.


The staging of lung cancer.

The staging of lung cancer.


Role of fiberoptic bronchoscopy in lung cancer.


A word of cautious dissent.

A word of cautious dissent.


Tumor immunotherapy: current trials and future developments.


A point about fetal hemoglobin determination in cord blood.


Familial Mediterranean fever in an Iraqi family.


Congenital cardiac anomalies in Goldenhar's syndrome. (Oculo-auriculo-vertebral dysplasia).


Familial microtia with meatal atresia in father and son.


A method for the determination of exchanged blood volume during exchange transfusion in newborn infants.


Immunologic and nonimmunologic hydrops fetalis.


Clinical and immunological studies in twenty families with ataxia-telangiectasia.


Use of Mafenide in burns of the hand.

Use of Mafenide in burns of the hand.


Life-threatening disease as a manageable crisis.


Development of immune mechanisms.

Development of immune mechanisms.


Ascorbic acid status in children with malnutrition.


Three cases of intra-abdominal rupture of the duodenum.


Factors that influence simple lung function tests with special reference to ethnic factors.


Evoked response audiometry and hearing impairment in adults.


Disc-electrophoretic study of serum proteins in maternal and cord blood and amniotic fluid.


Effect of tenotomy on the lipid composition of muscles with different biological functions.


Effect of elevated renal venous pressure on intrarenal haemodynamics.


The effect of hypoxia on thermoregulatory heat production and body temperature in the new-born and young guinea pig.


Activity of the corpus striatum of cats during natural sleep; a correlation analysis study.


Effect of physiological doses of vasopressin and oxytocin on avoidance and exploratory behaviour in rats.


3H-Melatonin level in cerebrospinal fluid and choroid plexus following intravenous administration of the labelled compound.


Effect of droperidol on the electrical activity of rabbit atrial cells.


Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.


Oestrogen containing oral contraceptives and antithrombin III activity. 67 women taking oral contraceptives were studied and compared with a group of normal women not taking oral contraceptives.  In the oral contraceptive group, 31 were taking Infecundin, a compound with high estrogen content, and 36 were taking Bisecurin, a compound with less estrogen.  Basic anthithrombin 3 (AT3) activity, as well as serum AT3, was determined in the presence of .25 IU/ml of heparin which normally increases thrombin inactivation.  A paradoxical decreased effect was obtained with heparin, more frequent in the Bisecurin group.  The basic determination of AT3 showed a decrease in 6 of 29 women taking Infecundin but a decrease was noted in 13 of the 29 controls, except in 1 case.  A fall in AT3 activity does not imply formation of intravascular clots but may be a factor if other disturbances are also present.  The determination may serve as a screening method.


Quantitative recording of turning behaviour induced or potentiated by amphetamine after unilateral brain lesions in the rat.


Self-stimulation and adrenocortical activity in young rats.


Facilitation of avoidance conditioning by nicotine: a function of individual learning ability.


Chronobiological aspects of endocrinology.


Circadian rhythms and the role of the pineal gland.


Preliminary clinical trials with a new plurichronocorticoid.


The treatment of connective tissue diseases with a new plurichronocorticoid.


Corticoid therapy in allergic diseases. Clinical evaluation of a chronopharmacological attempt.


Trial of a plurichronocorticoid in the dermatological field.


Plurichronocorticoid treatment of bronchial asthma and chronic bronchitis. Clinical and endocrino-metabolic evaluation.


Clinical evaluation of corticoid therapy in haematology.


Characteristics of urinary circadian rhythms in a young man evaluated on a monthly basis during the course of 21 months.


New studies on the experimental alteration of the circadian periodicity of plasma corticosteroid levels in the rat.


Axonal dystrophy in the spinal cords of cattle consuming the cycad palm, Cycas media.


Pathogenetic factors in tooth loss in young cats on a high daily oral intake of vitamin A.


Possible role of feline T-strain mycoplasmas in cat abortion.


Herd studies on the genital pathology of infertile beef cows.


Studies on the epizootiology of infection with avirulent Newcastle disease virus in broiler chicken flocks in Victoria.


Enzootic renal nosematosis in laboratory rabbits.


An outbreak of acute copper poisoning in calves.


Ocular manifestations of myeloproliferative disease in a cat.


Cestode parasites of the fox in the central tablelands of New South Wales.


Reduction in period of protection from artificial flystrike by organophosphorus and organophosphorus-carbamate resistant larvae of Lucilia cuprina.


Evaluation of a rectal-abdominal palpation technique for pregnancy diagnosis in sheep.


Reoviruses from chickens with hydropericardium.


Habitual abortion in cats.

Habitual abortion in cats.


Radiation and the human agar colony forming cell.


Effects of diethyl sulfate on the chromosome apparatus of mouse bone marrow cells.


Letter: Drug-induced red cell aplasia.

Letter: Drug-induced red cell aplasia.


The effect of dried thyroid gland pretreatment upon erythropoietic activity and development of anaemia in sublethally x-irradiated mice.


Effect of azidomorphine and related substances on the intestinal motility.


Dimensions and geometric relationships of the human aortic valve as a function of pressure.


A comparative study of corneal epithelial cell surfaces utilizing the scanning electron microscope.


Proliferation and growth of intestinal epithelium in Ascaris suum (Nematoda) during postnatal ontogeny. II. Increase in the number and size of cells as a growth factor.


The stratum corneum--some structural and functional correlates.


In vivo disposal kinetics of blood glucose carbon to hepatic and non-hepatic products in normal and diabetic rats.


Interaction of transferrin with iron-binding sites on rat intestinal epithelial cell plasma membranes.


Effects of alloxan diabetes on duodenal calcium-binding protein in the rat.


Adding and averaging angles: comparison of haptic-visual and visual-visual information integration.


Effects of nikethamide, picrotoxin and strychnine on 'amphetamine-state'.


Fast procedure of subjective colour measurement.


Masking of spatial and identity information from geometric forms by a visual noise field.


Effects of luminance and contrast on processing large disparities.


HL-A markers on human diploid skin fibroblasts.


The relations between color dominated responses on the Rorschach and explosive behavior in a hospital setting.


Accident and emergency care; the role of the nurse.


Evidence for two mechanisms of sclerotisation in insect cuticle.


Irrelevancy of creativity for rehabilitation.


Trade names or approved names. Part 1. The situation Substitution: right or wrong?


The production of androgen binding protein by Sertoli Cells.


FSH stimulation of testicular androgen binding protein (ABP). Androgen "priming" increases the response to FSH.


Androgen transport and receptor mechnisms in testis and epididymis.


Properties of rat testicular androgen binding proteins.


Eimeria Kosti sp. n., an abomasal coccidium from a cow.


Isolation of salmonellae from cattle at Dar es Salaam.


The incidence of brucellosis in game in Botswana.


Blood inorganic phosphorus levels of cattle in Botswana.


Prevention of anaemia by oral administration of iron dextran to newborn pigs.


An investigation of a Masai medicinal herbs Sumeita (Momordica pterocarpa Hoechest).


Toxicity of Adenia volkensii (Kiliambiti).


Coat colour and structure as an index of heat tolerance in some East African herbivores.


The epidemiology and economic importance of Oesophagustomum radiatum in Swaziland.


Experimental transmission of the stomatitis pneumoenteritis complex to sheep and goats.


Observations on the development of serum neutralizing antibody in rinderpest infection.


Isolation of salmonella from the bile of meat animals.


Bacteria and antibiotic sensitivity in clinical mastitis and latent infections in three dairy herds in Western and Lagos states of Nigeria.


Studies on spirochaetosis in fowls in the Sudan I. Epizootiology and experimental transmission.


Fowl spirochaetosis haematological and histopathological studies.


Antigenic relationship of various isolates of Corynebacterium pseudotuberculosis.


A case of nosemiasis in the rabbit.

A case of nosemiasis in the rabbit.


The use of "nilverm" (tetramisole) in the control of clinical signs of Thelazia rhodesii (eyeworm) infection in cattle.


Progress and problems of rabies control in Uganda.


African horse sickness in Nigeria--a case report.


Heartwater in imported brown Swiss Breed of Cattle in western Nigeria.


A serological survey of caprine brucellosis in Nigeria.


Factors contributing to the stability of a Glossina pallidipes Aust. population in the Lossitete forest.


Pig parasites of Nigeria: (iii) local pig industries in the plateau area of Northern Nigeria and their helmith problems at the peak of the rains.


Note on the sporocyst in Fasciola gigantica.


Observations on the behaviour of rinderpest virus in immune animals challenged intransally.


Observations of the incidence of Marek's disease in the domestic chicken at Kabete, Kenya.


Results of complement fixation test for contagious bovine pleuropneumonia after vaccination with T1 broth culture vaccine.


A survey of Salmonellae in goats and dogs in Nigeria.


Bovine brucellosis in two southern states of Nigeria; II. The incidence and implications of infection in range cattle.


The efficacy of T1 strain broth culture vaccine against contagious bovine pleuropneumonia: the effect of revaccination of cattle 6 months and 1 year after primary vaccination and prolonged exposure.


Serological reactions in experimental trypanosomiasis: protective effect of 7S immunoglobulins in Trypanosoma gambiense infection.


Renal, lymphoid and pulmonary lesions in naturally acquired canine angiostrongylosis in Uganda.


The helminthic infestations among cattle in the Senegal River Basin.


Incidence of lung worms infestation in sheep and cattle at Benghazi (Lybian Arabic Republic).


Establishment of Pakistan Zebu in Senegal.


Factors influencing perinatal wastage.

Factors influencing perinatal wastage.


The fetal electroencephalogram.

The fetal electroencephalogram.


Fetal circulation and breathing.

Fetal circulation and breathing.


Interpretation of the continuous fetal heart rate record.


Organisation of fetal intensive care.

Organisation of fetal intensive care.


Fetal growth.

Fetal growth.


Intensive care for the high-risk fetus in Africa.


Investigation of hypothalamic pituitary function.


The hormonal assessment of fetal and placental function.


The endometrium.

The endometrium.


Other disorders of ovulation.

Other disorders of ovulation.


The management of the infertile male.

The management of the infertile male.


Psychosocial factors in infertility.

Psychosocial factors in infertility.


Pregnancy following infertility.

Pregnancy following infertility.


The development, structure and function of the female pelvic organs in childhood.


Vulvovaginitis and other local lesions of the vulva.


Intersexuality.

Intersexuality.


Congenital malformations of the genital tract (excluding intersex).


Excessive menstrual bleeding and dysmenorrhoea.


Growth and secondary sexual development and related abnormalities.


Primary and secondary amenorrhoea.

Primary and secondary amenorrhoea.


Tumours of the genitalia.

Tumours of the genitalia.


A study of the influence during trituration of air-borne impurities on the strength of amalgam. The purpose of this study was to determined the effect of air-borne gaseous impurities, introduced during trituration, on the strength of amalgams. Four experiments were conducted. Each experiment consisted of a control group (1) in which the amalgam was triturated in air and an experimental group (2) in which the amalgam was triturated in argon, an inert gas. Standard specimens yielded mean diametral tensile strengths of 5950 psi (1) and 6603 psi (2). Hand compacted specimens yielded mean diametral tensile strengths of 5829 psi (1) and 6412 psi (2). Standard specimens yielded mean compacted hydraulically yielded mean uniaxial tensile strengths of 10,928 psi (1) and 11,660 psi (2). Statistically, the differences between the means for each experiment are significant. Hence, trituration in an inert gas has been shown to be an effective method for increasing the strength of amalgam.


Development of anithrombogenic cellulose electret materials.


A superficial survey of lung pathology.

A superficial survey of lung pathology.


Some diagnostic and therapeutic mistakes in mining practice.


"Mental" symptoms in organic disease.

"Mental" symptoms in organic disease.


A case of ptosis.

A case of ptosis.


Closed chest injuries in mining practice.


Intravenous regional anaesthesia method.


Ureteric injury complicating a fractured pelvis.


Three cases of intra-abdominal rupture of the duodenum.


Tendon injuries.

Tendon injuries.


Use of mafenide in burns of the hand.

Use of mafenide in burns of the hand.


Typhoid - a fresh look at the clinical picture and treatment.


Factors that influence simple lung function tests with special reference to ethnic factors.


Evoked response audiometry and hearing impairment in adults.


Drug uptake by brain. II. Barbiturate uptake alters the transport of amino acids in vitro(1). 1. Valine and leucine uptake into mouse brain slices was stimulated by 1 to 4 mM phenobarbital and pentobarbital. Greater concentrations of these two barbiturates inhibited the transport of these amino acids. Barbital, isobarbituric acid, and 5-nitrobarbituric acid had no effect, while amobarbital and secobarbital produced only inhibition of uptake. 2. Transport of glutamate and aspartate was unaffected by phenobarbital concentrations that inhibited uptake of lysine and alpha-aminoisobutyric acid. 3. Changes in the Na+ and K+ content of the slices were not related to stimulation of valine or leucine uptake. 4. There was no concentrative uptake of phenobarbital by brain slices. The partially saturable uptake of pentobarbital was not by active transport, because the uptake increased after heating brain, liver, or kidney slices to 95 degrees for 10 min. 5. This study shows that individual members of a pharmacologically related group may have specific effects on a composite physiological function (amino acid transport) of brain tissue.


Social comparison of abilities in blind children and adolescents.


Use of a video-cassette recorder for the assessment of teaching effectiveness.


Current status of biomedical book reviewing: Part III. Duplication patterns in biomedical book reviewing. This is the third part of a comprehensive, quantitative study of biomedical book reviewing. The data base of the total project was built from statistics of 3,347 reviews of 2,067 biomedical books appearing in all 1970 issues of fifty-four reviewing journals. This part of the study explores the duplication patterns in book reviewing among these media. It is found that 35.17% (727 books) of the 2,067 titles were reviewed more than once in 1970, these titles accounting for 2,007 of the total of 3,347 reviews. For the most part, reviews of the most frequently reviewed titles appeared in such journals as British Medical Journal, Annals of Internal Medicine, Lancet, Journal of the American Medical Association, and New England Journal of Medicine. These five journals covered 93.53% of the 727 books reviewed more than once in 1970.


Mood and social perception in four alcoholics. Effects of drinking and assertion training.


Tracheobronchopathia osteochondroplastica.


Muscle survival following free muscle transfer with microvascular anastomosis.


Editorial: Aneurysmal bone cyst.

Editorial: Aneurysmal bone cyst.


Influence of rabbit mink upon cholesterolaemic response of offspring of rabbits.


Patients' reactions to their therapist's pregnancies.


Proceedings: Some aspects of the use of B.C.G. in the treatment of advanced malignant disease.


Bullous pemphigoid.

Bullous pemphigoid.


Serum creatine kinase in acute psychosis.


Doxepine therapy in outpatients with depressive anxious states.


Touchstones in critical care medicine--an introduction.


Requirements of Acholeplasma laidlawii A, strain LA 1, for nucleic acid precursors.


Reproducibility of measurement of fetal biparietal diameter by ultrasonic cephalometry.


Fetal metabolic response to maternal starvation.


Antenatal diagnosis and management of the small-for-gestational age fetus.


Fetal growth retardation. Animal model: uterine vessel ligation in the pregnant rat.


Characteristic cellular changes in exfoliated oral epithelial cells in diabetes mellitus, Cooley's anaemia, kwashiorkor and rheumatic heart disease in children.


Surgery of giant horse-shoe retinal tear extending behind the equator of the globe by an oblique encircling silastic 3 mm band passing posterior to the tear without evacuation of the subretinal fluid.


The significance of gynecomastia.

The significance of gynecomastia.


Trial of trimethoprim-sulphamethoxazole in infantile gastroenteritis.


Electrical properties of hydrated collagen. II. Semiconductor properties.


Letter: Conformational changes of polypeptides on crystallization.


Effect of pituitary stalk lesion on water and carbohydrate metabolisms in alloxan-diabetic rats.


Congenital lymphoedema (Milroy's disease). A report of 10 cases in a family.


Intestinal brush border enzyme activity in juvenile and maturity onset diabetes mellitus.


An ego disturbance model of MBD.

An ego disturbance model of MBD.


Proceedings: Some speculations concerning a possible biochemical basis of minimal brain dysfunction.


Effect of PGA2 and PGB1 on the rat foetal müllerian duct "in vitro": absence of relationship to testicular anti-müllerian hormone.


Effect of curarization on energy and nitrogen balances in acute tetanus treated by prolonged administration of D tubo-curarine.


Parthyriod hormone and calcitonin in idopathic hypercalciuria.


The foramina of the cervical vertebrae of the ox. Part 1: atlas and axis.


Maternal experience prevents pup-killing in mice induced by peripheral anosmia.


Site-dependent differences in rejection of tumor cells with and without preimmunization.


Effect of exogenous ubiquinone-10 on the ubiquinone pool of liver and spleen of mice.


In vivo toxicity of concanavalin A.

In vivo toxicity of concanavalin A.


Effects of low-dose cingestol on blood coagultation: a long term follow-up.


Effect of repeated injections of polyriboinosinic-polyribocytidylic acid on mouse hematopoietic stem cells.


Genotypic differences in the ossification of 12 day old mice at 23 degrees C and 32 degrees C.


Tumor regression and enhancement resulting from immunotherapy with Bacillus Calmette-Guérin and neuraminidase.


An assay permitting quantitative comparison of tumor-directed immunity and tumor cell survival.


Testicular function in mouse strains with different age of sexual maturation.


Inheritance of avoidance behavior in Mus musculus.


Effect of Corynebacterium parvum on cytotoxicity of regional and nonregional lymph node cells from animals with tumors present or removed.


Inhibition of bone marrow cell proliferation in burned mice. An in vitro study of the effect of fluid replacement and burn serum on bone marrow cell growth.


Effects of concanavalin A on the migration of radioactively labeled lymphoid cells.


Changes in the homing properties of labeled lymphoid cells caused by solid tumor growth.


Separation of the specific antigen of a mouse lymphoma from histocompatibility antigens.


Synergistic effect of pactamycin and sparsomycin on Mycoplasma-induced lethal toxicity of mice. Pactamycin and sparsomycin, antitumor drugs which act synergistically with endotoxins, also potentiate the lethal toxicity of mice by Mycoplasma fermentans, strain K10. Sparsomycin (50 mug/20 g mouse, injected intraperitoneally 1 h after various doses of M. fermentans) exerted a minimal degree of synergism with few extra deaths, but with prolonged appearance of nonlethal disease. Pactamycin (75 mug in the same protocol) increased susceptibility to Mycoplasma-induced lethal toxicity approximately 1,000-fold. The optimal response was noted when pactamycin was administered in the period between 6 h before and 3 h after the administration of 10(8) colony-forming units of viable mycoplasmas. Doses of 12.5, 25, or 50 mug increased severity of signs, but only 75 mug/mouse produced synergism of the lethal effect. Methylprednisolone partially negated the synergism when injected simultaneously with the pactamycin 1 h after the cells. The lethal synergistic effect occurred with four species of Mycoplasma in addition to M. fermentans.


Letters to the editor: Industry's credibility.


The chemical control of human ectoparasites.


Letter: Intraperitoneal 99mTc-sulfur colloid distribution.


Feasibility of consecutive-day Schilling tests.


A method of tomographic imaging using a multiple pinhole-coded aperture.


Counseling the coronary patient.

Counseling the coronary patient.


On the inverse relationship between methane and propionate in the rumen.


Fetal brain growth: selective action by growth hormone. Growth hormone was administered to pregnant rats maintained under dietary control, and fetal and placental growth and nutrition were examined. Growth hormone had a selective action on brain growth that could not be attributed to nutrient mobilization but suggested a trophic factor which is unique to the brain.


Neural regulation of muscle activation.

Neural regulation of muscle activation.


Changes in postnatal development of acetylcholinesterase in the hippocampal region after early septal lesions in the rat.


Reinforcement frequency and body weight as determinants of motivated performance in hypothalamic hyperphagic rats.


Cricopharyngeal achalasia in childhood.

Cricopharyngeal achalasia in childhood.


Esophageal achalasia: diagnosis and cardiomyotomy in a newborn infant.


Fine structural localisation of acid phosphatase in neural tumours induced by N-ethyl-N-nitrosourea in rats.


Endoscopy in achalasia.

Endoscopy in achalasia.


Pseudomembranous colitis associated with ampicillin therapy.


The oral arterial ammonia test in cirrhosis of the liver, with a note on the role of esophageal varices.


Nature of the unusual branched-chain fatty acids in the triglycerides of the barley-fed lamb.


Progressive supplementation of barley with amino acids in a pig diet.


Lipogenesis in rabbit isolated fat-cells. 1. Fat-cells isolated from rabbit perirenal adipose tissue were incubated with the following U-(14)C-labelled substrates: 5mm-glucose (+insulin), 5mm-pyruvate, 5mm-lactate, 5mm-glucose+5mm-acetate (+insulin), and the relative rates of incorporation of these substrates into glyceride fatty acids determined. In general total rates of fatty acid synthesis were similar whatever substrate was supplied to the cells. 2. Rabbit fat-cells incorporated [U-(14)C]acetate into fatty acids and CO(2) as well in the absence of glucose as in the presence of this substrate. 3. The disposition of the utilization of glucose-derived carbon through various metabolic pathways was determined. 4. Extramitochondrial and mitochondrial activities were determined for 11 enzymes. The cells contained a very low activity of pyruvate carboxylase, undetectable NADP-malate dehydrogenase activity and a high mitochondrial phosphoenolpyruvate carboxylase activity. 5. Various rabbit fat-cell metabolic parameters based on the measurement of (14)C incorporation and enzyme activity were compared with the same parameters previously measured in rat and guinea-pig fat-cells. In general guinea pig occupied a position between rat and rabbit with respect to these parameters. 6. The profiles of substrate incorporation into fatty acids and of relative enzyme activities in rabbit fat-cells indicated that the operation of a ;citrate-cleavage' pathway may not be obligatory for the supply of lipogenic acetyl units.


Hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase from Plasmodium chabaudi, purification and properties.


Unilateral ovariectomy during pregnancy in mice.


Letter: Treatment of nicotine addiction with Avena sativa.


The hemolytic-uremic syndrome in siblings: a prospective survey.


An endoperoxide aggregator (Lass), formed in platelets in response to thrombotic stimuli: purification, identification and unique biological significance.


Hypoconvertinemia.

Hypoconvertinemia.


The effect of interpersonal censure on the cognitive performance of active process and reactive schizophrenic patients.


Some tests of response habituation in rats with discrete lesions to the orbital or medial frontal cortex.


On the molecular basis for vascular calcification.


A study of social and psychological characteristics of adolescent suicide attempters in an urban, disadvantaged area.


Sex and today's youth.

Sex and today's youth. Changes in sexual activities and attitudes of today's (1974) youth are reviewed.  It is concluded that adolescent sexual behavior is not much different from what it was in the last decade, although young people tend to have their 1st sexual experience earlier than in the past and tend to talk about sex more openly.  The percent of women who are not virgins at marriage is not markedly higher than it was in the 1920s, nor has the incidence of school-age unwed mothers increased in the last few years.  It has become increasingly popular for young, unmarried men and women to live together in recent years and coed dorms have become more widespread, although little sexual activity occurs among the inhabitants of these dorms.  The incidence of premarital sex among engaged couples has increased.  Young and middle-aged couples today are more ready to experiment with variations in foreplay and coitus.  Homosexuals live more comfortably with their sexual behavior and the rate of transexualism has risen.  Drug users are more likely to have coitus earler in life, more regularly, and with a greater number of partners.


The eye and its disorders. 22. Conjunctiva.


The alcoholic stereotype: clinical reappraisal and implications for treatment.


Homos and heteros among the hemos.

Homos and heteros among the hemos.


The relationship of disease and other stress to second language.


Reversal by L-dopa of impaired learning due to destruction of the dopaminergic nigro-neostriatal projection. Rats receiving bilateral stereotaxic injections of 6-hydroxydopamine into the zona compacta of the substantia nigra failed to learn a one-way active avoidance response. Small doses of L-dopa (1.5 milligrams per kilogram of body weight) in combination with a peripheral decarboxylase inhibitor reversed this impairment. Animals with lesions which acquired the avoidance response during L-dopa administration retained this response when drug treatment was discontinued. These experiments suggest that the dopaminergic nigro-neostriatal projection serves a critical function in the acquisition of learned instrumental responses.


Non-equivalence of vertical and horizontal planes in stripe discrimination by monkeys.


Attitudes of women in management. I. Job satisfaction: a study of perceived need satisfaction as a function of job level.


Preventive ophthalmology.

Preventive ophthalmology.


Epididymitis due to Schistosoma haematobium infection. Four cases of Schistosoma haematobium-infection of the epididymis are reported. Histological examination showed an intense granulomatous infiltration of the epididymis with calcified eggs of Schistosoma haematobium.


The discontinuity in the ontogeny of self: possibilities for integration or destructiveness.


Fetus-in-fetu: An ususual cause for abdominal mass in infancy. Fetus-in-fetu is an unusual cause of retroperitoneal abdominal mass in infants, which most likely arises from inclusion of a monozygotic, diamniotic twin. This entity is distinguished from teratoma by its embryological origin, its unusual location in the retroperitoneal space, its invariable benignity, and by the presence of vertebral organization with limb buds and well-developed organ systems. Diagnosis is made radiographically by the finding of a diminutive vertebral column on a plain abdominal film. The treatment of choice is total excision with special attention being given to the fetus' blood supply which may be directly from the host's superior mesenteric vessels. A well-documented example of this unusual entity that occurred in a six-week old infant male is presented.


The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis I. Message stability in development.


Effect of oestradiol-17beta and oxytocin treatment on prostaglandin F alpha release in the anoestrous ewe.


The effects of prostaglandin F2 alpha and ovariectomy on the peripheral plasma steroid concentrations and the evolution of myometrial activity in the pregnant rabbit.


Correspondence. Operating room flash fire.


A case of bovine cerebral listeriosis with ocular lesion.


A case of transient global amnesia due to a pituitary tumor.


A clinical study of dystocia in cattle. I. Treatment.


A clinical study of dystocia in cattle. 2. Complications.


A comparison of pentagastrin injection and calcium infusion as provocative agents for the detection of medullary carcinoma of the thyroid.


A comparison of fibroblast and smooth muscle myosins.


A comparison of the transcription of mouse cell chromatin by homologous RNA polymerase I and II.


A light sensor technique for monitoring respiration of anaesthetised animals.


A critique of the present and proposed strategies for redistributing resources in the health sector and a discussion of alternatives.


A method for analyzing the genetic basis of covariation.


A modified procedure for the rapid isolation of fibrino-peptides.


A new bioassay for luteinizing hormone.

A new bioassay for luteinizing hormone.


A new procedure for labelling luteinizing hormone with tritium.


A comparison between pancuronium and tubocurarine administration in injured men.


A prologue to retirement.

A prologue to retirement.


A rapid procedure for derivatizing agarose with a variety of carbohydrates: its use for affinity chromatography of lectins.


A recessive disorder with growth and mental retardation, peculiar facies, abnormal pigmentation, hepatic cirrhosis and aminoaciduria.


A sephadex column radioimmunoassay of unconjugated estriol in pregnancy plasma.


A study of consanguinity in Fukuoka population effects of inbreeding on fertility and sterility.


A tetragonal crystal form of horse spleen apoferritin and its relationship to the cubic modification.


A versatile transducer system for mechanical studies of muscle.


A viscometric assay for pullulanase-type, debranching enzymes.


Acute pulmonary histoplasmosis.

Acute pulmonary histoplasmosis.


Age distribution of patients with Parkinson's disease in 1960 and 1970 in 110 hospitals.


Aggression and social controls in rhesus monkey (Macaca mulatta) groups revealed in group formation studies.


Alpha-(Ureidomethylene)lactones and derived 5-(hydroxyalkyl)uracils.


Alterations in incidence of mating and copulation-induced ovulation after olfactory bulb ablation in female rats.


Ambulatory surgical gynecology: an overview.


A study of surface and deep temperatures along the course of the ulnar nerve in the pisohamate tunnel.


An effect of the female genotype on sperm transport in mice.


An epidemiological study of oesophageal atresia.


An evaluation of the utility of benzoyl-DL-arginine-beta-naphthyl-amide for the assay of thrombin activity in blood.


An improved mutarotase assay using beta-D-glucose oxidase and an oxygen electrode.


Anaerobic growth and formation of respiration-deficient mutants of various species of yeasts.


Analysis of isoaccepting tRNAs during the growth phase mitotic cycle of Physarum polycephalum.


Analysis of dye binding sites in mast cell granules.


Anesthesia and the mini-surgicenter for ambulatory surgical gynecology.


Anti-inflammatory activity of various agents producing hyperlipemia in rats.


An electron microscopic study of normal and chronically denervated rat skeletal muscle following succinylcholine challenge.


Antihypertensives. 1. Syntheses of thiazino-, thiazepino-, and thiazoninoethylguanidines.


Argon laser slitlamp photocoagulation. Indications and results.


Ascorbic acid influence on larval blood cell number and susceptibility to bacterial and fungal infection in the codling moth, Laspeyresia pomonella (Lepidoptera: Tortricidae).


Atomic absorption determination of mercury in fish using the coleman MAS-50 mercury analyzer.


Automated analysis of available lysine and tyrosine in foodstuffs.


Automated enzymatic determination of L-lysine in grain.


Autoradiographic study of protein synthesis in abdominal tissues of Glossina austeni.


Bacteriocine production in group B streptococci.


Behaviour changes in mice following electrolytic lesions in the median hypothalamus.


Another example of human chimerism.

Another example of human chimerism.


Bemegride antagonism to the development of physical dependence on barbitone in rodents.


Binding of proteins to CNBr-activated sepharose 4B.


Biochemical aspects of the visual process. XXVI. Binding site and migration of retinaldehyde during rhodopsin photolysis.


Biosynthesis. XX. Biosynthesis of c-homoaporphines in Kreysigia multiflora.


Bringing health to the nation.

Bringing health to the nation.


Bromo-, chloro-, and amino-derivatives of 5alpha-androstane and 5alpha-oestrane.


Bulk separation of Purkinje cells and granular cells from small amounts of cerebellar tissue.


C-nucleoside studies. I. Synthesis of (2,3,5-tri-O-benzyl-alpha(and beta)-D-ribofuranosyl)ethyne.


Caffeine enhancement of chemical carcinogen-induced transformation of cultured Syrian hamster cells.


Canine hip dysplasia: effects of pectineal myectomy on the coxofemoral joints of Greyhound and German Shepherd dogs.


Calf lens crystallin messenger RNA's contain polynucleotide sequences rich in adenylic acid. Calf lens messenger fractions have been purified on poly(dT)-cellulose. The purified RNA's have been analyzed as nucleosides by a method which can be used on a micro-scale with highly reproduceble results. Both the 10S and 14S lens mRNA contain poly A sequences. The poly A content found in 14S mRNA cannot account for the excess nucleotides in this message.


Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis.


Catheterization of the common umbilical vein for chronic fetal lamb studies.


Catalytic activity of aortic lysyl oxidase in an insoluble enzyme-substrate complex.


Cell growth and division in hypertonic medium.


Characterization of a photoexposed sulfhydryl group of bovine rhodopsin available for chemical modification.


Changes in the polysome content of developing Xenopus laevis embryos.


Characterization of a Chinese hamster cell with a temperature-sensitive mutation in folate metabolism.


Case history number 80: respiratory depression in the recovery room.


Chemical modification of cholera toxin for characterization of antigenic, receptor-binding and toxic sites.


Chemical relaxation studies on bovine serum albumin. I. Reactions of the imidazole groups at pH 6 to 8.


Cholesterol-phosphatidylcholine interactions in vesicle systems. Implication of vesicle size and proton magnetic resonance line-width changes.


Chorio-carcinoma associated with porphobilinogenuria. A case report.


Cerebrovascular CO2 reactivity of the fast and slow clearing compartments.


Chromatographic analysis of heptaene macrolide antibiotics.


Circular dichroism and thermal denaturation studies of chromatin and DNA from BrdU-treated mouse fibroblasts.


Comparative kinetic properties of alpha, beta and psi forms of trypsin.


Competitive binding of bilirubin, sulfobromophthalein, indocyanine green and other organic anions to human and bovine serum albumin.


Complement-fixing and lymphocytotoxic antibodies in serum of pregnant women at delivery.


Cooperative regional studies with growing swine: effects of vitamin E and levels of supplementary copper during the growing-finishing period on gain, feed conversion and tissue copper storage in swine.


Conversion of 20alpha-hydroxy-4-pregnen-3-one to 20alpha-hydroxy-5alpha-pregnan-3-one and 5alpha-pregnane-3alpha, 20alpha-diol by rat anterior pituitary.


Conversion of metallothionein into Cu-thionein, the possible low molecular weight form of neonatal hepatic mitochondrocuprein.


Corpus luteum adequacy in the ageing pregnant mouse.


Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures.


Clinical experience with pancuronium bromide in children.


Daily concentrations of plasma LH, FSH, estradiol, estrone and progesterone throughout the menstrual cycle.


Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution.


Delayed onset of sexual activity of male rats subjected to pre- and postnatal undernutrition.


Delayed transfusion reaction associated with multiple antibodies.


Determination of handedness using hand-efficiency tests.


Correlations between changes of activity of the renal sympathetic nerve and behavioural events in unrestrained cats.


Detecting small quantities of DNA on CsCl gradients.


Detection of tumour-associated transplantation antigen of BO-IV carcinoma on somatic cells of tumour-free syngeneic mice. 3. Demonstration of this antigen on the lymphoreticular system of adult mice.


Determination of plasma fibrinogen concentration by the modified clot-weight method.


Correspondence: Grading of severity of leprosy.


Development of ovarian follicles correlated to levels of serum FSH and LH during long-term oral contraception.


Development of preimplantation rabbit embryos in vivo and in vitro.


Diagnostic value of urinary amylase in patients with pancreatic carcinoma.


Differential effects of amygdaloid and hippocampal lesions on female puberty.


Dimensions and volumes of left atrium and ventricle determined by single beam echocardiography.


Dimerization of brain hexokinase induced by its regulator glucose 6-phosphate.


Directions for academic institutions in health services review.


Distribution and excretion of 115mcadmium and its transfer to egg and bone in laying female and estrogenized male Japanese quail.


Deep hypothermia and diethyl ether anesthesia for open-heart surgery in infants: a clinical report of 8 years' experience.


Diurnal variation in the effect of tolbutamide.


Diurnal patterns of DNA synthesis in the rat: modification by diet and feeding schedule.


Diurnal variations in plasma corticosterone and cations of male rats on two lighting schedules.


Dog-fighting dogs.

Dog-fighting dogs.


Dominance and mating behavior in ram lambs.


Dose-response relationships between exogenous progesterone and estradiol and porcine uterine protein secretions.


Duodenal protein infusions and plasma glucose, urea and amino acid levels in sheep.


Dynamic studies on the portal hemodynamics by scintiphotosplenoportography: the visualization of portal venous system using 99mTc.


Dynamic structure of DNA modified with the carcinogen N-acetoxy-n-2-acetylaminofluorene.


Dynamics of the diurnal rhythm of mitotic activity in the pancreatic acinar cells after disturbance of their innervation.


DNA chain growth during replication of asynchronous L1210 cells. Alkaline elution of large DNA segments from cells lysed on filters.


DNA synthesis and transformation induced in density-inhibited cultures of hamster embryo cells by the carcinogen benzo(alpha)pyrene.


Editorial: "To whom am I speaking?".

Editorial: "To whom am I speaking?".


Eastern equine encephalitis virus. Quantitative study of the effects of interferon on virus replication.


Editorial: Catheters and incontinence.

Editorial: Catheters and incontinence.


Editorial: Enough.

Editorial: Enough.


Editorial: International use of tranquilizers.


Editorial: Judging the quality of medical care.


Effect of colchicine on mitotic behavior of fibroblast-like cells of line 237 of Chinese hamsters.


Effect of divalent cations on the daunomycin-deoxyribonucleic acid complex.


Effect of dietary calcium-phosphorus and nasal irritation on turbinate morphology and performance in pigs.


Effect of hypothalamic deafferentation on luteinization of intrasplenic ovarian grafts in the ovariectomized rat.


Effect of lactate infusions on patients with myasthenia gravis.


Effect of narcotics on enzymes of acetylcholine metabolism in cultured cells from embryonic chick brains.


Effect of phospholipid on conformation of ovine luteinizing hormone as tested by circular dichroism.


Effect of septal ablation on rhythmic pituitary-adrenal function in the rat.


Effect of 6-thioguanine on mitotic coiling of the chromosomes.


Effects of cation binding on the conformation of calsequestrin and the high affinity calcium-binding protein of sarcoplasmic reticulum.


Effects of ethanol on shock-elicited fighting behavior in rats.


Effects of hysterectomy on milk secretion and serum levels of prolactin, growth hormone, estrogen, and progesterone in rhesus monkeys with hormone-induced uterine hypertrophy.


Effects of morphine on plasma lipids in the rabbit.


Effects of steroid hormones on gonadotrophin secretion in female rats after ovariectomy during the oestrous cycle.


Electrical impedance of malignant and normal rat thymus cells.


Efficacy of supplemental selenium in reproductive diets on sow and progeny performance.


Endocrine activity in postmenopausal ovaries.


Enhancement of the optical rotation of alpha-amino-acids by formation of carbamate (N-carboxy-) salts.


Essential thrombocythaemia and peripheral gangrene. Six patients are described in whom gangrene of one or more toes occurred as the presenting feature of essential thrombocythaemia. Spontaneous platelet aggregation was observed in platelet-rich plasma from four patients and platelet aggregation after the addition of adenosine diphosphate and collagen was highly abnormal in samples from all six. All of the patients described dramatic relief of pain within six hours of ingestion of aspirin and this coincided with disappearance of the spontaneous platelet aggregation and collagen-induced platelet aggregation. Treatment with phosphorus-32 corrected the platelet count and there were no further recurrences of peripheral vascular disease. Platelet function tests performed at the time all gave normal results. It is concluded that essential thrombocythaemia is an important and treatable cause of peripheral vascular disease.


Establishment of physical dependence mice by oral ingestion of morphine.


Effect of DDS therapy on the acetylcholine sweat function test in fifty cases of tuberculoid and maculoanesthetic leprosy.


Estimation of pharmacokinetic parameters of lithium from saliva and urine.


Examination of soil in the brisbane area for organisms of the Mycobacterium avium-intracellulare-scrofulaceum complex.


Exercise myoglobinemia and acute exertional rhabdomyolysis.


Exercise-induced bronchial lability in atopic children and their families.


Effects of surface-induced deep hypothermia, diethyl-ether anesthesia, and respiratory alkalosis on myocardial metabolism following total circulatory arrest in dogs.


Experimental investigation of toxicity of cadmium and zinc caprylates.


Fate of the ring moiety of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide in mammalian cells.


Experimental papillary necrosis of the kidney. IV. Medullary plasma flow. To test the thesis that vasoconstriction plays a significant role in the pathogenesis of papillary necrosis caused by bromoethylamine hydrobromide (BEA), medullary plasma flow was determined in rats treated with BEA. Medullary blood flow was normal (1/2) to 1 hour after BEA treatment, and was actually elevated 6 hours after BEA. There was no increase in plasma levels of prostaglandins A and E, which would have been expected if there had been medullary ischemia. Pretreatment with reserpine, which inhibited the development of papillary necrosis, had little effect on medullary plasma flow. These observations do not support the notion that vasoconstriction is the mechanism by which BEA causes papillary necrosis.


Fate of arsenic after parenteral administration to rats, with particular reference to excretion via bile.


Fetal growth in relation to histamine concentration in urine.


Fibrin degradation products and the 125I-labeled fibrinogen test in patients with myocardial infarction.


Fluorescence cytochemistry of the ovary in the rhesus monkey, Macaca mulatta.


Fibrinopeptide A immunoreactivity in human plasma.


Fluorescence studies on the interaction between pyridoxal phosphate enzymes.


Formation of some novel 9beta-methyl-19-norpregnane derivatives.


Further characterization of two co-lipases from porcine pancreas.


Further investigations on transcription during oogenesis and immediately after activation by sperm in Limnaea (mollusca) eggs.


Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition.


Genetic determinants of cranio-facial morphology: a twin study.


Glucosamine incorporation during the mitotic cycle of primary chicken fibroblast cells.


Gonadotrophin secretion after electrical stimulation of the preoptic area during the oestrous cycle of the rat.


Granulomatous inflammation in splenectomy specimens. Clinicopathologic study of 20 cases.


Growth and respiration throughout the life-cycle of Nematospiroides dubius Baylis (1926) (Nematoda: Heligmosomidae): the parasitic stages.


Granulomatous lymphadenitis caused by Corynebacterium ovis.


Genetic component of lung function.

Genetic component of lung function.


Growth standards for twins from birth to four years.


Head trauma in children.

Head trauma in children.


Heterocyclic studies. XXXV. Cleavage of fervenulin and 3-methyl-fervenulin by nucleophiles.


Heterosexual aversion in homosexual males. A second experiment.


Home eye test roundup.

Home eye test roundup.


HeLa-like marker chromosomes and type-A variant glucose-6-phosphate dehydrogenase isoenzyme in human cell cultures producing Mason-Pfizer monkey virus-like particles.


Hormone profiles in normally menstruating and infertile women.


Host restriction of friend leukemia virus; fate of input virion RNA.


Host skin mucus as a hatching stimulant in Acanthocotyle lobianchi, a monogenean from the skin of Raja spp.


Human infection by an acanthocephalan Macracanthorhynchus hirudinaceus in Thailand: new light on a previous case.


Human nasal exocrine IgA antibody: formation and some activities.


Identification of sparganum growth factor by a radioreceptor assay for growth hormone.


In vitro evaluation of 1-beta-D-arabinofuranosylcytosine-beta-2'-deoxythioguanosine combination chemotherapy.


Immunoglobulin M in the cerebrospinal fluid of patients with arbovirus encephalitis and other infections of the central nervous system.


In vitro cultivation of Fasciolopsis buski.


Increased polyunsaturated fatty acid yields in milk cows fed protected fat.


Induction of physical dependence on morphine, codeine and meperidine in the rat by continuous infusion.


Infection with Toxoplasma in Lusaka, Zambia.


Influence of estrus synchronization with MAP on the cytochemical appearance of tertiary follicles in the ovary of the Texel ewe.


Influence of nursing on the release of prolactin and GH in mice with high and low incidence of mammary tumors.


Influence of platelet factor 4 on inhibited thrombin substrate reactions.


Inhibition of membrane calcium activation by neomycin and streptomycin in crab muscle fibers.


Interactions of a mitochondrial Ca2+-binding glycoprotein with lipid bilayer membranes.


Interactions of a purified non-histone chromosomal protein with DNA and histone.


Interruption of pregnancy in rats by various fluoroandrostane derivatives.


Interactions of C-reactive protein with the complement system. I. Protamine-induced consumption of complement in acute phase sera. Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37 degrees C, 0.10 M relative salt concentration and pH 7.5-8.0; it required calcium ions. It was mediated by a heat-stable nondialyzable factor which separated with C-reactive protein (CRP) during fractionation and purification, correlated with serum CRP levels, and, like other known reactivities of CRP, was inhibited by phosphoryl choline. Preparations of CRP purified either from serum or ascites resulted in consumption of large amounts of C1, C4, and C2 when preincubated with normal serum and protamine. We conclude that CRP is a potent activator of the C system at the level of C1, and that polycations such as protamine sulfate are substrates of CRP which can bring about this activation. It seems not unlikely that one role of CRP in health and disease involves its ability to interact with the C system.


Intersexuality in a Cocker spaniel dog.

Intersexuality in a Cocker spaniel dog.


Intracellular bicarbonate in single cells of Necturus kidney proximal tubule.


Irreversible inhibition of aspartate aminotransferase by 2-amino-3-butenoic acid.


Intracellular bicarbonate in single skeletal muscle fibers.


Isolation and characterisation of bis-phosphatidic acid and its partially deacylated derivatives from cultured BHK-cells.


Isolation and characterization of a highly cross-linked peptide from elastin of porcine aorta.


Isolation and characterization of glucose oxidase from mycelium and nutrient of Penicillium notatum cultures.


Isolation of lymphoma cell variants resistant to killing by glucocorticoids.


Isolation of fatty acids from the mycelium of Penicillium stipitatum Thom and their effect on Ehrlich ascites carcinoma cells.


Interactions of gallamine and pancuronium with tubocurarine under morphine-nitrous oxide-oxygen anesthesia in man.


Kinetic studies on binding of bovine serum albumin with 1-anilino-8-naphthalene sulfonate.


Leadership: a better you--a better me.

Leadership: a better you--a better me.


Letter: "A flea in his ear".

Letter: "A flea in his ear".


Leptotrombidium scutellare as a vector of scrub typhus at the endemic area of the foothills of Mt. Fuju, Japan.


Letter: Diagnosis of gonorrhea and the 1974 Red Book.


Letter: Difficulties of classification and terminology of syndromes of multiple congenital anomalies.


Letter: Dissent of PSRO's.

Letter: Dissent of PSRO's.


Letter: Diphyllobothrium latum (fish tapeworm) in the Sioux Lookout zone.


Letter: Echocardiographic diagnosis of idiopathic hypertrophic subaortic stenosis.


Letter: Leptospira hardjo with abortions in a group of heifers.


Letter: Placidyl poisoning or withdrawal?


Letter: Propranolol in the treatment of migraine.


Letter: PSRO legislation.

Letter: PSRO legislation.


Legislation regulating emergency medical care.


Jet ventilation for microlaryngoscopic procedures: a further simplified technic.


Letter: Chaulmoogra account protest.

Letter: Chaulmoogra account protest.


Lack of thiopental effect on the oxyhemoglobin-dissociation curve.


Limiting amino acids in milo for the growing pig.


Lipid composition of frog virus 3.

Lipid composition of frog virus 3.


Localization and origin of antidiuretic principle in para-endocrine-active malignant tumors.


Mammalian cells: damage in late replicating DNA as the most efficient cause of reproductive death.


Luteotrophic action of decidual tissue in the rat.


Mammalian hepatic lectin.

Mammalian hepatic lectin. A rabbit hepatic protein that specifically binds asialoglycoproteins is also a lectin that agglutinates untreated human and rabbit erythrocytes and neuraminidase-treated erythrocytes from rat, mouse, and guinea pig. Both binding of asialoglycoproteins and agglutination of erythrocytes appear to involve reaction on the same active sites of the hepatic protein.


Manual immunoephelometric assay of proteins, with use of polymer enhancement.


Management of extrahepatic portal hypertension in children. Among 69 patients with PVT, 338 variceal bleeding episodes occurred. Only two patients died from bleeding, and both lived in remote communities and were inaccessible to medical care. Fifty-three children underwent 164 operations for the management of PVT. Once operative management was undertaken, subsequent operations frequently were necessary. Nonoperative measures controlled acute variceal hemorrhage in most instances during the past 10 years. Almost all patients who underwent splenectomy alone, variceal ligation, gastric division, splenic transposition, or makeshift shunts subsequently rebled. These operations are rarely indicated in the current management of children with PVT. Portal venography is essential to define the portal venous circulation before a shunt operation is attempted. Cavomesenteric or central splenorenal shunts prevented further bleeding in eight of 15 patients and are the most reliable operations to control bleeding in patients with PVT. Emergency operation is rarely necessary to control bleeding. Sixteen patients (average age 14.6 years) with PVT did not undergo any operations, and are alive. Each of the six patients with PVT who died from complications of portal hypertension did so within nine months of an operation. Four of these patients had previous splenectomy and died with sepsis as one of the major factors. Bleeding episodes became less frequent as the patients increased in age. Patients who underwent shunts under unfavorable circumstances or who received various other operations to treat portal hypertension appeared to have a higher risk of morbidity and mortality than those managed nonoperatively.


Measurement of antibodies on insulin in serum.


Measurement of serum ferritin by a 2-site immunoradiometric assay.


Letter: Questions and answers. Dental procedures.


Mercury in commercial canned sea food.

Mercury in commercial canned sea food.


Letter: The effect of spontaneous ventilation on blood gases in obstetric patients under general anesthesia.


Microbiological hydroxylation. XII. Comparative behaviour of D-homogonane (perhydrochrysene) ketones and steroids.


Metabolically controlled killing of Pasteurella septica by antibody and complement.


Letter: Use of drugs and their effects on leprosy patients.


Microbiological hydroxylation. 8. Cyclododecanone and cyclopentadecanone as substrates for steroid-hydroxylating fungi.


Mixed gonadal dysgenesis. A case report.


Modification of the isolation-induced abnormal behavior in male Wistar rats by destructive manipulation of the central monoaminergic systems.


Monitoring the ovarian response to gonadotropin therapy.


Morphological and cytochemical characteristics of neurons in cultures of mouse sympathetic ganglia.


Mucocutaneous lymph node syndrome (MLNS): a disease widespread in Japan which demands our attention.


Mutants of cultured chinese hamster cells deficient in adenine phosphoribosyl transferase.


Multiple ribonuclease H activities from BHK-21-C13 cells.


National nutritional planning.

National nutritional planning.


Nasal clearance in monozygotic twins.

Nasal clearance in monozygotic twins.


New endocrine observations in a male patient with choriocarcinoma.


Maternal deprivation in the rat: prevention of mortality by nonlactating adults.


Medical education of foreign physicians in the United States.


New metabolic products of Fusarium culmorum: toxic trichothec-9-en-8-ones and 2-acetylquinazolin-4(3h)-one.


Nippostrongylus brasiliensis: the distribution of primary worm populations within the small intestine of neonatal rats.


Nitrogen components reaching the omasum and abomasum of lambs fed two nitrogen levels.


Notes of a biology-watcher. On transcendental metaworry (TMW).


Non-random loss of human markers from man-mouse somatic cell hybrids.


Nuclear concentration of 3H-estrogen in ovarian tissue of the neonatal rat.


Observations on rat and mouse oocyte maturation in vivo and in vitro: morphology and physiology.


Nucleotide sequence of the anticodon region of Torulopsis phenylalanine transfer RNA.


Observations on the development of two echinostomes, Echinoparyphium recurvatum and Echinostoma revolutum, the antagonists of human schistosomes in Egypt.


Occurrence of fatty acid methyl esters and cholesterol in a molecular complex with riboflavin.


Optical rotation and the DNA helix-to-coil transition. An undergraduate project.


On the binding of actinomycin and of daunomycin to DNA: a calorimetric and spectroscopic investigation.


Ovarian steroidogenesis resulting from treatment with menopausal gonadotropin.


Ovarian morphology after administration of an oral contraceptive. An investigation in the rhesus monkey.


Oxygen consumption of nonfiltering dog kidneys.


P-component (pentagonal unit) of amyloid: isolation, characterization, and sequence analysis.


Periodic paralysis caused by abuse of thyroid hormone.


Pesticide residues. Improved gas-liquid chromatographic method for determining ethylenethiourea in plants.


Phenobarbital-induced coagulation defects in cats.


Photoluminescence studies of molecular interactions. I. Synthesis of some indolyl ketones and tryptophan analogues.


Photooxidation of ferrocyanide and iodide ions and associated phosphorylation in NH2OH-treated chloroplasts.


Observations on the changing face of heroin addiction in a San Francisco clinic population.


Pigeon-breeder's disease: study of the cell-mediated immune response to pigeon antigens by the lymphocyte culture technique.


Plain catgut for skin closures.

Plain catgut for skin closures.


Plasma dopa concentrations and the "on-off" effect after chronic treatment of Parkinson's disease.


Plasma thyrotropic activity in a man with choriocarcinoma.


Photochemical conversions of lower aldehydes in aqueous solutions and in fog.


Poly(A) in mRNA does not contribute to secondary structure necessary for protein synthesis.


Plasma 20alpha-hydroxypregn-4-en-3-one in the normal menstrual cycle.


Polymerization behavior of bovine zinc-insulin at neutral pH. Molecular weight of the subunit and the effect of glucose.


Posterior urethral valves: diagnosis and management.


Postreplication repair of ultraviolet damage to DNA in xeroderma pigmentosum, other human and mouse cells in culture.


Possible relationships between extracellular potassium activity and presynaptic inhibition in the spinal cord of the cat.


Potential collateral circulation to the human cerebral cortex.


Preferential synthesis of actin during early development of the slime mold Dictyostelium discoideum.


Preparation and decomposition of some steroidal 4'beta,5'-dihydro-(17alpha, 16-c)pyrazoles.


Preliminary report on the incidence of larvae of the family Rhabditidae (Nematoda) in the eyes of rodents.


Preparation of 5alpha-(3beta-2H) cholestan-3alpha-ol by isomerization reactions.


Primary cardiac angiosarcoma.

Primary cardiac angiosarcoma.


Problems of juvenile delinquency.

Problems of juvenile delinquency.


Proceedings: Effect of salmon calcitonin treatment on bone turnover, cardiac output and oxygen transport in patients with Paget's disease.


Proceedings: The effect of insulin on parathyroid cells in culture.


Proceedings: Sideroblastic anaemia.

Proceedings: Sideroblastic anaemia.


Professional Standards review Organizations and Quality Assurance Programs--they're not the same.


Production of an Fc fragment from human immunoglobulin A by an IgA-specific bacterial protease.


Prehospital life-support systems in traumatic and cardiac emergencies.


Progesterone and clomifene influence and stereologically estimated endometrial parameters.


Progesterone antagonism of androgen-dependent aggression-promoting pheromone in inbred mice (Mus musculus).


Protein quality for the nonruminant herbivore.


Protein synthesis during embryogenesis of Sabellaria alveolata L. (polychaete annelid).


Proteochondroitin sulfate synthesis and chondrogenic expression.


Public accountability: The name of the game.


Purification and properties of a human urinary kallikrein (kininogenase).


Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase I from the mouse myeloma, MOPC 315.


Purification of the specific cell-aggregating factor from embryonic neural retina cells.


PSRO in Maine--an update.

PSRO in Maine--an update.


Prolonged release of 4,4'-diaminodiphenylsulphone (DDS) by incorporation in silicone rubber. A preliminary report.


Pyrroles and related compounds. 33. Total synthesis of deuteriated derivatives of protoporphyrin-IX for nuclear magnetic resonance studies of haemoproteins.


Quality control in microbiology. II. The need for standards.


Radiation therapy: testicular tumors.

Radiation therapy: testicular tumors.


Radioautography of 17beta-estradiol in vivo under different hormonal conditions.


Radioimmunoassay of human placental lactogen synthesized on ribosomes isolated from first trimester and third trimester placentae.


Radioimmunoassay of pituitary and plasma prolactin during the oestrous cycle in mice.


Rate of electron transfer between plastocyanin, cytochrome f, related proteins and artificial redox reagents in solution.


Rates of dissociation and recombination of the subunits of bovine thyrotropin.


Recent developments in treatment of childhood cancer.


Reaction of pyridoxal 5'-sulfate with apoenzyme of aspartate aminotransferase. Covalent labeling of the protein with elimination of sulfate.


Reduction of the 24,25-double bond of lanosterol in vivo in the rat. Stereochemistry of the addition of the C-25 proton in the biosynthesis of cholesterol.


Regulation of placental growth and metabolism by ovarian and hypophyseal hormonal stimuli.


Relation between ovarian and myometrial function.


Relationship between concentrations of maternal plasma oestrogens and progesterone and response to artificial rupture of membranes. The concentrations of oestradiol-17beta, oestriol, and progesterone were measured in the plasma of 100 patients at the time of induction of labour by artificial rupture of membranes. There was no statistically significant difference in the hormone concentration or in the ratio of oestrogens to progesterone between patients who went into labour after rupture of the membranes and those who did not. Nor was there any significant difference in the hormone values between oxytocin-sensitive and oxytocin-insensitive patients.


Relationship between protein and DNA structure in calf thymus chromatin. II. Conformational aspects.


Removal of 3H-T-HCl and acrosome loss from spermatozoa of different species in the presence of reproductive tract secretions.