Isolation and characterization of the S-carboxymethyl derivatives of crosslinked and noncrosslinked human fibrin. The S-carboxymethyl derivative chains of crosslinked and noncrosslinked fibrins were prepared from purified human fibrinogen. For crosslinked fibrin, fibrinogen was clotted with thrombin in the presence of calcium and purified human factor XIII. For noncrosslinked fibrin, ethylenediaminetetraacetate was substituted for factor XIII and calcium. After reduction with dithiothrcitol and alkylation with tritiated iodoacetic acid, the derivative chains were separated on carboxymethyl cellulose in a sodium acetate-pH gradient that contained 8 M urea. Purity of the separated chains was determined by polyacrylamide gel electrophoresis at acid and at neutral pH. The derivative chains of noncrosslinked fibrin were eluted from carboxymethyl cellulose in the order: gamma-chain, beta-chain, and alpha-chain. Each of the purified derivative chains was characterized and identified by amino-terminal aminoacid analysis, aminoacid composition, tryptic peptide mapping, and molecular weight estimation by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. In like manner, the derivative components of crosslinked fibrin were eluted from carboxymethyl cellulose in the order: gamma-gamma-dimer, beta-chain, and alpha-polymer. Application of the same analytical criteria and comparision with the derivatives of noncrosslinked fibrin confirmed the identity of these components. These data provide conclusive evidence that crosslinking of human fibrin involves formation of peptide bonds between two gamma-chains to form gamma-gamma-dimer and between multiple alpha-chains to form high molecular weight polymers of alpha-chains.


Synergistic effect of rifamycin derivatives and amphotericin B on viral transformation of a murine cell line. One of the most potent inhibitors of RNA-dependent DNA polymerase activity so far described (rifazacyclo-16) was not correspondingly as active in focus inhibition. This discrepancy was thought to be due to the inability of the drug to penetrate the cell membrane. It has been found that a very low level of amphotericin B allows this drug, as well as the previously described 2',6'-dimethyl-N(4')benzyl-N(4')-[desmethyl] rifampicin, to exhibit a very high capability to inhibit focus formation. Since these two drugs are highly lipophilie, their activity may be expected to be dependent upon any lipophilic components in the medium, such as serum or detergents. The use of amphotericin B as well as serum in tissue cultures is common, and could account for some of the variability in focus inhibition reported in the literature.


Precursors of collagen secreted by cultured human fibroblasts. Soluble precursors of collagen ("procollagens") in the culture medium of human diploid fibroblasts were characterized by molecular sieve chromatography on 6% agarose and by sodium dodecyl sulfate-acrylamide gel electrophoresis. Under the denaturing conditions for gels, the following molecular species were identified: a major species of three procollagen chains, a procollagen dimer, and free procollagen chains. Reduction with 2-mercaptoethanol completely dissociated the trimer and dimer, releasing procollagen alpha1 and procollagen alpha2 chains with molecular weights of about 120,000. Both pro alpha1 and pro alpha2 chains could be labeled with [(35)S]cystine. In addition, free procollagen chains with molecular weights of less than 120,000, but heavier than native alpha chains, were identified in gels. Radioactivity in all of the above molecules could be chased into native alpha chains extracted from extracellular fibers of the cell layers. The data indicate that: (i) collagen is secreted as a disulfidestabilized procollagen trimer with the composition, (pro alpha1)(2).pro alpha2; (ii) noncovalent interactions maintain the three-chain assembly during stepwise enzymatic excisions of N-terminal, cysteine-containing procellagen peptides; and (iii) after such excisions, native helical molecules, (alpha1)(2).alpha2, precipitate as fibers in the cell layers.


Partial duplication in the "hinge" region of IgA 1  myeloma proteins. The aminoacid sequence of the "hinge" region of two human IgA(1) myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA(2) myeloma protein, it is possible that IgA(1) molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.


Assembly of rod-shaped virus in vitro: reconstitution with cucumber green mottle mosaic virus protein and tobacco mosaic virus RNA. In vitro assembly of tobacco mosaic virus (TMV) from its constituent RNA and protein occurs in two steps: formation of the initial complex by interaction of the 5'-end of TMV-RNA with 20S protein aggregate, and growth of the helical rod by sequential addition of protein subunits.Such a process was also observed in the assembly of cucumber green mottle mosaic virus, which is also a rodshaped virus. The 13S virus-protein aggregate, probably a single-ring structure, is needed for formation of the initial complex, instead of the 20S double-ring structure for TMV. The 13S aggregate cannot effect growth of the initial complex to a long infective rod. Rod elongation takes place by the sequential addition of protein subunits. In general, the assembly of rod-shaped viruses occurs in two steps, and the protein aggregate is essential only for initiation of the reaction, not for rod elongation.


Occurrence of uridylate-rich oligonucleotide regions in heterogeneous nuclear RNA of HeLa cells. Heterogeneous nuclear RNA molecules from HeLa cells contain a specific segment of about 30 nucleotides length that is largely (about 80%) uridylic acid. This oligo(U) segment is located predominantly in the larger (70S-90S) heterogeneous nuclear RNA molecules, and is essentially absent in messenger RNA and 45S ribosomal precursor RNA molecules. The oligo(U) hybridizes rapidly to cellular DNA, suggesting that it is transcribed from the repeated regions of the DNA.


Alkylamine-dependent amino-acid oxidation by lysine monooxygenase--fragmented substrate of oxygenase. Lysine monooxygenase catalyzes the oxygenative decarboxylation of L-lysine and produces a corresponding acid amide. L-Alanine was inactive as substrate. However, when propylamine was present, oxidation, but not oxygenation, of alanine was demonstrated with the oxygenase. Alanine was converted to pyruvate, with the liberation of ammonia and hydrogen peroxide, but propylamine remained unchanged. Other alpha-monoamino acids were also oxidized in the presence of alkylamines with various carbon chain lengths. The highest oxidase activity was observed when the total chain length of both amino acid and amine was nearly identical with that of lysine. Available evidence indicates that the amine-dependent amino-acid oxidase activity is associated with the lysine oxygenase activity.


Purification of insulin-specific protease by affinity chromatography. A single enzyme that proteolytically degrades insulin was isolated from rat skeletal muscle. This enzyme was purified 1000-fold by a series of steps, including affinity chromatography on insulin bound to agarose at the NH(2)-terminal phenylalanine of the B chain. Insulin linked to agarose at the B-29 lysine residue did not bind the enzyme and, therefore, was not suitable for purification procedures. Insulin linked at the phenylalanine residue was a substrate for the enzyme and was degraded by it; insulin attached to agarose at the lysine residue was not degraded by the enzyme. The purified enzyme preparation yielded one major band on polyacrylamide gel electrophoresis, and elution of this area of the gel yielded insulin-degrading activity. The purified enzyme degraded insulin but not proinsulin, with a K(m) for insulin of 22 nM and a K(i) for proinsulin of 40 nM. The enzyme is sulfhydryl-dependent, with a physiological pH optimum.


Intracellular iron-binding macromolecules in HeLa cells. The concentration of the iron-chelating agent, desferrioxamine (Desferal), that just inhibits iron entry into HeLa cells is also the concentration that inhibits DNA synthesis. As a first step in clarification of the mechanism whereby iron may partake in DNA synthesis, we have partially characterized several of the intracellular iron-binding sites. Most cytoplasmic iron appears to be bound to a polysaccharide containing glucose that sediments at about 32 S. Nucleolar iron is bound to a single protein, the mobility of which is independent of the concentration of sodium dodecyl sulfate in an acrylamide gel. In contrast the pattern and mobility of nuclear iron, other than nucleolar, is heterogeneous and markedly affected by the concentration of sodium dodecyl sulfate. The evidence suggests that nuclear iron is bound to protein through one or more intermediate(s).


Reversible transformation by urea of contact-inhibited fibroblasts. 200 mM urea elicits alterations of cell social behavior in vitro. In the presence of urea, contact inhibition of movement and growth is reduced compared to untreated fibroblastic cell populations. This reduction of contact inhibition is rapidly reversible, but reversal requires some cycloheximide-sensitive cellular process. Cells treated with urea are agglutinable by concanavalin A, suggesting that urea might remove some cell-surface component(s). A nondialyzable factor can, in fact, be detected in the supernatant medium of urea-treated cells. This active constituent appears to be heat-labile and trypsin-sensitive, and can itself restore normal contact-inhibitory behavior to cells maintained in the urea-transformed state by cycloheximide. This system may permit identification and characterization of surface components that are involved in regulating normal cell social behavior.


Hapten-conjugated antibodies and visual markers used to label cell-surface antigens for electron microscopy: an approach to double labeling. Haptens can be coupled to mouse immunoglobulin with retention of antibody specificity. Such hapten-coupled alloantibody, when bound to cells, can be bridged to an electron microscopic marker in two ways: (i) by a hybrid antibody, i.e., anti-hapten:anti-marker, and (ii) by untreated bivalent anti-hapten antibody if the marker is also haptenized. Through the use of immunologically non-crossreactive haptens and markers it should be possible to localize multiple, different antigens on the surface of an individual cell. Double labeling has been achieved with the first method.


Nuclear DNA sequences present in human leukemic cells and absent in normal leukocytes. The central purpose of the present study was to test the proposition that the nuclear DNA of every human cell contains whatever information is necessary and sufficient for transformation to malignancy. The experiments were made possible by our earlier identification in human leukemic cells of particulate elements encapsulating 70S RNA and RNA-directed DNA polymerase. The [(3)H]DNA synthesized by these particles was used as a probe, through molecular hybridization, to normal and leukemic DNA. The results obtained establish that leukemic nuclear DNA contains particle-related sequences that cannot be detected in normal leukocytes. This outcome does not support the virogene-oncogene theory, which postulates the inclusion of at least one complete copy of oncogenic information in the genome of every normal cell. The data suggest that we may not be forced to cope with an omnipresent DNA segment coding for malignancy. Under the circumstances, we can perhaps entertain more hopeful pathways leading to the control and cure of cancer.


Ion-diffusion potentials and electrical rectification across lipid membranes activated by excitation-induced material. Membranes synthesized from sphingomyelin-tocopherol mixtures and treated with the protein, "excitation-inducing material," to increase their electrical conductance were tested for applicability of the Nernst equation and changes in electrical rectifying behavior with temperature. Above pH 7, and in the temperature range 303-323 degrees K, ion-diffusion potentials created by salts of monovalent cations showed that areas of the membrane activated by excitation-inducing material were only permeable to cations. Results also indicated that a parallel current with an activation energy of 1.00 eV per molecule passed through unactivated areas of the membrane. Below pH 7, the ratio of measured diffusion potentials to predicted values decreased steadily. Electrical rectification was exhibited by membranes activated by excitation-inducing material with positive current consistently passing preferentially from the side rich in excitation-inducing material to the opposite side. For a given membrane, the current-voltage curves did not change from 312 to 323 degrees K; but below 312 degrees K, the membrane suddenly increased its conductance and became ohmic. This phenomenon was independent of salt concentration and pH, and resembled a phase transition.


Time-variant conductance of bilayer membranes treated with monazomycin and alamethicin. Experimental data obtained on bilayer membranes treated with either of two antibiotics, monazomycin or alamethicin, are presented showing the marked difference in the time course of the rise and subsequent decay of the conductance in response to a positive and negative step of potential established by means of a voltage-clamp feedback circuit. The variation of the conductance with time in these model systems qualitatively mimics the behavior of the "potassium conductance" of squid giant axons and other excitable biological systems; namely, the rise of the conductance to the steady state requires a longer time than its decay to the resting state. For the alamethicin system, the decay time becomes very brief-as short as 50 musec-as either the salt or the alamethicin concentration is reduced, while the rise time remains several seconds. This marked brevity of the decay time versus the rise time may have implications for the mechanism underlying the formation of conducting channels in such membranes.


Fluorescence studies of the binding of the polyene antibiotics filipin 3, amphotericin B, nystatin, and lagosin to cholesterol. The interactions of filipin III, amphotericin B, nystatin, and lagosin with sterols in aqueous suspension and in vesicles were followed by fluorescence excitation spectra and by measurement of polarized fluorescence intensities. The equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin III > amphotericin B > nystatin > lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes. Fluorescence polarization measurements show that hydrophobic forces are primarily responsible for the formation of the complexes. Filipin III undergoes a large enhancement in fluorescence polarization on binding to aqueous suspensions of cholesterol and epi-cholesterol, and to vesicles of lecithin-cholesterol, lecithin-beta-cholestanol, and lecithinergosterol. Small increases in polarization occur on interaction of filipin III with vesicles derived from lecithin and epi-cholesterol, thiocholesterol, and androstan-3beta-ol. Amphotericin B undergoes a relatively constant enhancement in fluorescence polarization on interaction with the various lecithin-sterol vesicles used and does not display the selectivity exhibited by filipin III. It is suggested that filipin III serves as a probe of lecithin-sterol interaction.


Altered chlorplast ribosomal proteins associated with erythromycin-resistant mutants in two genetic systems of Chlamydomonas reinhardi. The phenotype of several erythromycin-resistant mutants of Chlamydomonas reinhardi was further characterized in terms of the electrophoretic properties of their chloroplast ribosomal proteins. In mutant ery-M2d a single protein of the large (52 S) subunit has altered properties, which probably result from a change in its primary sequence. This mutation is inherited in a Meudelian manner. In mutant ery-U1a, which is inherited in a uniparental manner, a different single protein of the 52 S subunit is altered. This change might result from a change in either the primary sequence of the protein or in some form of secondary modification. These results indicate that these two distinct genetic systems must cooperate in the production of chloroplast ribosomes.


Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure. A tentative amino-acid sequence for the COOH-terminal half of rabbit skeletal tropomyosin is reported. These studies confirm our previous conclusions that this tropomyosin consists of several different but similar polypeptide chains. In the sequence, nonpolar residues occur in two series at intervals of seven residues. Amino-acid residues in series I are three residues on the NH(2)-terminal side of, and four residues on the COOH-terminal side of, residues in series II. The presence of occasional charged or ambivalent residues in the positions of series I or II does not lead to a disruption of this long-range pattern. The majority of residues located between the nonpolar residues are charged or polar amino acids. Two highly similar or identical alpha-helices with the reported sequence can be packed together in parallel in a coiled-coil structure. These may be in register or staggered by seven residues or some multiple of it. The observation that groups of small hydrophobic side chains appear to alternate with groups of bulky side chains suggests that a staggered arrangement of the two alpha-helices would maximize the regularity and hydrophobic interactions of the coiled-coil. Model building considerations show that this would occur with a stagger of 14 residues. Such an arrangement could account for the end-to-end aggregation of tropomyosin in solution, and in crystal and tactoid filaments. However, a structure in which the two polypeptides are in register cannot be ruled out.


Ethidium bromide as a cooperative effector of a DNA structure. A salt-induced cooperative conformational transition of a synthetic DNA, poly(dG-dC), is reversed by addition of ethidium bromide. Binding of the dye at high salt concentrations is highly cooperative. Circular dichroism spectra of the complex and the kinetic data support a model for this cooperative binding that is formally equivalent to the "allosteric" one proposed for oligomeric proteins by Monod et al. Thus, double-helical DNA of at least one defined sequence can undergo a cooperative conformational change in solution, with simple salts and drug molecules as antagonistic effectors. Such transitions may be involved in regulatory phenomena operating directly at the level of nucleic acid structure.


Environment--an elastic limit to growth.


Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Thymidine kinase(-) lines of mouse L cells incorporate thymidine exclusively into mitochondrial DNA. This fact permits assessment of labeled mitochondrial DNA components in ethidium bromide-cesium chloride gradients. Contaminating nuclear DNA is unlabeled and need not be removed. Elimination of the DNase treatment of purified mitochondria reveals that the replicative forms that exhibit displacement replication up to full genome size are covalently-closed circular molecules. Denaturation followed by brief renaturation of these larger replicating molecules produces closed-circular DNA with a deficiency of Watson-Crick turns, appearing as single-strand loops. This result suggests that displacement replication proceeds with nicking and rapid closure of the covalently-closed circular template.


The free clinic movement enters West Virginia.


A study of optimum population levels--a progress report. The purpose of this study is to explore different approaches and to develop a methodology that will allow a calculation of "optimum levels of population." The discussion is specialized to the United States, but the methodology should be broad enough to handle other countries, including less-developed countries. The study is based on economics, but with major inputs from the areas of technology, natural resources management, environmental effects, and demography. The general approach will be to develop an index for quality of life (IQL or Q-index) and to maximize this index as a function of level and distribution of population. The technique consists of a reshuffling of national income accounts so as to be able to go from the Gross National Product (GNP) to the index for quality of life, plus a careful discussion of what is and what is not to be included. The initial part of the study consists of a projection of the index for quality of life as population level increases and as population distribution changes, under the assumption of various technologies, particularly as these relate to the consumption of minerals, energy, and other natural resources. One would expect that as economic growth continues, an increasing fraction of expenditures would be for the diseconomics produced by population growth and economic growth. This study should be useful by providing a rational base for governmental policies regarding population, both in the United States and abroad. Another application of the study is to technology assessment, by measurement of the impact on economic well-being through the introduction of new technologies. Therefore, one can gauge the necessary and desirable investments in certain new technologies. In general, mathematical models resulting from this study can become useful diagnostic tools to analyze the consequences of various public and private policy decisions.


Clinical applications of the carotid sinus relfex.


Studies in periodontal pathology.

Studies in periodontal pathology.


Current aspects of digitalis therapy.

Current aspects of digitalis therapy.


Usual and customary: philosophy and fees.


A new method of measuring facial geometry.


The marble technique: a method for treating the "hopeless gagger" for complete dentures.


The pantograph as a face-bow transfer instrument.


A cephalometric study of tooth position as related to facial structure in profiles of human beings: a comparison of Japanese (Oriental) and American (Caucasian) adults.


Ceka extracoronal attachments.

Ceka extracoronal attachments.


Concept of modern dentistry.

Concept of modern dentistry.


An investigation into the lighting requirements for operative dentistry.


Analysis of amalgam cavity design.

Analysis of amalgam cavity design.


The accurate contouring of preformed crowns.


The challenge of acupuncture.

The challenge of acupuncture.


The focal point.

The focal point.


The relationship between fear and intelligence in the child patient.


Periodontal disease and oral hygiene in 2383 Moroccan school children aged eight and twelve years.


Continuous versus intermittent feedings of different levels of trimetaphosphate in relation to caries development in the rat.


The effect of alloxan diabetes on gingival collagen metabolism in rats.


Effects of prepubertal castration on development of granular tubules and amylase activity in the male mouse submandibular gland.


The pattern of tooth loss in a selected population of Nigerians.


Periodontal and facial influences on the laryngeal input to the brain stem of the cat.


Effects of controlled tooth stimulation of jaw muscle activity in man.


Morphologic effects of hypervitaminosis A on rat submandibular gland.


In-vivo incorporation of ( 35 S)-sulphate into submandibular gland sulpholipids in the rat.


The effect of pH and temperature on the crystal growth of hydroxyapatite.


Liver citrate levels in parathyroidectomized rats fed toxic amounts of inorganic fluoride.


Psychiatric sequelae to a civil disturbance.


Perianal and anorectal complications in leukemia.


Monoblast of acute monoblastic leukemia.


Host immunity to growing sarcomas: tumor-specific serum inhibition of tumor-specific cellular immunity.


Choosing mechanical breathing equipment.


The art of medicating hyperkinetic children. A number of practical suggestions.


Effect of irradiation on established delayed hypersensitivity. Suppression of skin reactions, recovery and the effect of cell transfer.


The protecting capacity of neutralizing antibodies by distemper virus infections in mink.


Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 1. The enhanced x-ray sensitivity of virus infected mice.


Variant of the B character in group A 1 B with anti-BH in serum.


Caffeine sensitive recovery of mitomycin C treated mouse P-388 cells.


Fimbriation and colony type of Moraxella bovis in relation to conjunctival colonization and development of keratoconjunctivitis in cattle.


Neisseria elongata. Presentation of new isolates.


Freund's adjuvants: their influence on the specificity of viral antisera.


Treatment of Tourette's syndrome with haloperidol, review of 34 cases.


Glycogen in erythroid cells.

Glycogen in erythroid cells.


A practical guide to assisted operating. 4. Instrument handling. 2.


Bilateral inferior alveolar and lingual nerve block.


An unusual complication of the extraction of a lower molar. A case report.


Histology of the premaxillary=vomerine suture in a bilateral cleft case.


Pharyngeal flap as a primary and secondary procedure.


The effect on middle ear disease of fracture of the pterygoid hamulus during palatoplasty.


Phonetic contexts: their effects on perceived nasality in cleft palate speakers.


OFD I syndrome and mental retardation.

OFD I syndrome and mental retardation.


Oral form discrimination in individuals with normal and cleft palates.


Audiometrically "normal" conductive hearing losses among the cleft palate.


The effect of severe hydrocephalus on size and number of brain cells.


Hyrdodynamics of Holter ventriculo-atrial shunt systems under various conditions.


Electrical potentials of the lamina epithelialis choroidea of the fourth ventricle of the cat in vitro: relationship to the CSF blood potential.


The rôle of the skull and dura in experimental feline hydrocephalus.


Positive gallium 677 photoscan in myeloblastoma.


Variability of the submandibular flow rate in man with special reference to the size of the gland.


The flow rate, pH and buffer effect of mixed saliva in schoolchildren.


Hypodontia of both primary and permanent central upper incisor. Description of a case.


Fluoride content of enamel surface treated with a varnish containing sodium fluoride.


Poor relations in management.

Poor relations in management.


Interpretation of the orthopantomogram. Complications due to radiographic artifacts.


The role of the filler-matrix interface in composite restorative materials based on poly(methylmethacrylate).


An evaluation of lead foil in dental X-ray film packets. 1. Factors affecting the intensity of back-scattered radiation and the effect of this radiation on radiographic contrast when density is allowed to increase.


A practical guide to assisted operating. 2. Aspiration.


Pericoronitis due to a centipede. A case report.


Practice management. Reflections by an adult educationist.


Malignant disease in children whose mothers had chickenpox, mumps, or rubella in pregnancy. To test the hypothesis that leukaemia may follow virus infection in pregnancy an analysis was made of deaths which occurred in a cohort of children born in 1951 and 1952 after pregnancies in which the mothers suffered virus infections-chickenpox or mumps at any stage of gestation or rubella in the first 18 weeks. All deaths which occurred between the children's second birthday and the end of 1971 were studied.Two deaths from leukaemia occurred among the children whose mothers suffered from chickenpox, a significant excess. There were no deaths from leukaemia among the other children, but the causes of the two deaths after maternal mumps-Ewing's tumour and Still's disease-are noted because of their rarity.


The biomechanics of tooth movement with Begg.


Early treatment of Class II occlusion.

Early treatment of Class II occlusion.


A two-phase slicing technique for space allocation.


Academy president voices concern on new dental era.


Need for better public relations. Why the fuss?


A self-directed approach to the treatment of a complex neurosis with implosive therapy.


Plaque acid production in hamsters pretreated with fluoride.


Electric pulp vitality testers.

Electric pulp vitality testers.


Relation of body mass to respiration in rodent incisor pulp.


Parameters of the mixed dentition in diabetic children.


An electromyographic feedback technique for teaching voluntary relaxation of the masseter muscle.


A new dental superalloy system. II. Mechanical properties.


A new dental superalloy system. I. Theory and alloy design.


Inheritance of tooth size in immigrant populations.


Fluoride uptake and acid solubility of enamel exposed to carboxylate cement containing MFP.


A new dental superalloy system. 3. Microstructure and phase transformations.


Scanning electron microscope study of dentin exposed by contact facets and cervical abrasion.


A study of the diurnal characteristics of calcium in stimulated mixed human saliva.


N-methyl-N-nitrosurea-induced odontogenic neoplasms in rats.


Comparison of the dentinal crazing ability of retention pins and machinist's taps.


Statistical tests for the OHI-S and PI: a commentary.


Bactericidal efficiency of some antimicrobial chemicals.


Three-rooted mandibular permanent molars in English Caucasians.


Effects of dimethyl sulfoxide on developing avian bones.


Cortisol metabolism in the fetal and neonatal sheep.


A calcifiable bacillary variant isolated from Bacterionema matruchotii, ATCC 14266.


Some physical properties of an admixed high copper amalgam.


Determination of mercury in parotid fluid.


Studies in the design and analysis of dental experiments. 14. Replicate latin squares.


Incorporation of fluoride by human enamel. 3. In vivo effects of nonfluoride and fluoride prophylactic pastes and APF gels.


Heritability of the Carabelli cusp in twins.


Role of attrition and occlusal contact in the physiology of the rat incisor. VI. Impeded and unimpeded eruption in hypophysectomized and magnesium-deficient rats.


Genetic factors in the shape of the craniofacial complex.


A cephalometric study of Class II relapse.


Organic tissue characteristics on the pressure side of human premolars following tooth movement.


Microprobe analysis of amalgam. I. Effect of surface preparation.


The failure of aging or loss of teeth to drastically alter mandibular angle morphology.


Further studies of resin-modified temporary restorative materials.


Structural strength of the interface between bone and nondegradable porous ceramic implants.


Growth formulas in Class II treatment.

Growth formulas in Class II treatment.


Congenitally absent maxillary lateral incisors: treatment planning considerations.


Influence of inherent dietary calcium and phosphorus on the cariostatic properties of NaH 2 PO 4  in the rat.


Correction of impacted mandibular second molars.


Profile preferences among diversified groups.


Relationship between plaque mineralization in vitro and calculus formation in vivo.


Monozygotic twins showing differences in occlusion.


Newer studies of radiation exposure in cephalometric roentgenography utilizing the rando head phantom.


Extraction in orthodontics: premises and prerequisites.


The systems approach.

The systems approach.


The intercuspal surface contact area registration: an additional tool for evaluation of normal occlusion.


Solitary oral neurilemmoma.

Solitary oral neurilemmoma.


The selection and properties of materials for dental practice. 1. Principles of selection.


The economic case for delegation in dentistry.


Dentistry in Israel.

Dentistry in Israel.


Transfer of amalgam into a carrier.

Transfer of amalgam into a carrier.


Effect of different occlusal profiles on the masticatory forces transmitted by complete dentures. An evaluation.


Verruciform xanthoma of the gingiva: report of six cases.


Community dentistry and periodontology: a reciprocal affinity.


Longitudinal study of periodontal therapy.


Correlation of dental calculus weights with Volpe Manhold Index scores.


Interrelationship of dietary factors and heredity in calculus formation and periodontal lesions in the gerbil.


Observations on the periodontium and acquired pellicle of adult germfree dogs.


Scanning electron microscopy of supragingival calculus.


Geographic change in Rhode Island's private medical practices 1950-1965.


Partial ileal bypass in the management of familial type II hyperlipoproteinemia.


Early clinical diagnosis of oral cancer.


Verrucous carcinoma.

Verrucous carcinoma.


Erythroplakia of the mouth.

Erythroplakia of the mouth.


The value of exfoliative cytology in the diagnosis of oral cancer.


The prevalence of oral and dental disease and its bearing on the delivery of dental services and in dental education.


Recruitment and selection of students--motivational factors.


The relevance of research to dental education and dental practice.


Marking of dentures--follow-up.

Marking of dentures--follow-up.


Your security.

Your security.


Federal income tax returns by dentists.

Federal income tax returns by dentists.


Epidemiology of malocclusion in 12 year old Winnipeg school children.


The Assiniboine dental group practice.

The Assiniboine dental group practice.


Treatment of cardiogenic shock. II.

Treatment of cardiogenic shock. II.


Fifty-nine year old female with abdominal pain of twenty-four hours duration.


Candida endophthalmitis. Successful treatment in a patient with acute leukemia.


Excitability changes in trigeminal primary afferent fibres elicited by dental pulp stimulation in the cat.


A study of the enhancement of glycolysis in human saliva.


Characterization of plasma membranes isolated from rat submandibular salivary glands.


The effect of cortisone on collagen synthesis in the secondary palate of mice.


The secretory rate of the human submandibular glands in response to parasympathicomimetic and gustatory stimulation.


A previously unreported cytoplasmic granule in the epithelium of inflamed human gingiva.


The presence of atypical collagen fibrils in EDTA decalcified predentine and dentine of rat incisors.


The effect of the lathyritic agent aminoacetonitrile on the unimpeded eruption rate in normal and root-resected rat lower incisors.


Light microscopic observations on the formation of the layer of Hopewell-Smith in human teeth.


Cell division and periodontal ligament formation in the mouse.


Trigger wrist: report of two cases.

Trigger wrist: report of two cases.


A pressure limiting valve for anaesthetic and respirator circuits.


Modification of an adult ventilator to an infant ventilator.


The interaction between wheat germ agglutinin and human leukemic blast cells.


Amino acid metabolism during exercise in McArdle's syndrome: evidence of altered alanine metabolism.


Treatment of acute respiratory failure in chronic obstructive pulmonary disease: results without a special respiratory care unit.


Stevens-Johnson syndrome, report of a case with possible systemic reaction to acute alcoholism.


Case report: acute lymphatic leukemia followed by a clinical picture indistinguishable from chronic granulocytic leukemia in the same patient.


In vitro studies of bone marrow in refractory anaemia.


Psychological questionnaire design for oral diagnosis.


Dermatoglyphic variation in the South Midlands.


The Hammersmith Hospital Anaemia Unit, and the Medical Research Council's Leukaemia Unit at the Royal Postgraduate Medical School.


The effects of simultaneous disruptive and stabilising selection.


Correlation of cytology and clinical findings in pemphigus vulgaris.


Observations on the participation of nurses and physicians in chronic care.


The patients' needs and the changing role of health manpower: a view from the Dr. Martin Luther King Jr. Health Center.


Rheology of leukocytes, leukocyte suspensions, and blood in leukemia. Possible relationship to clinical manifestations. Suspensions of leukemic lymphocytes and myeloblasts and blood of leukemic patients were studied to examine (a) the effect of leukemic cells on blood viscosity and (b) the ability of leukemic cells to traverse channels of capillary diameter. The viscosity of suspensions of leukemic cells was dependent logarithmically on (a) shear strain rate and (b) cytocrit, although, suspensions of small lymphocytes and of myeloblasts had a similar viscosity at equivalent shear rates and cytocrit. The minimum apparent viscosity (MAV) of leukemic cells and red blood cells, measured over shear rates of 2.3-230 s(-1) was dependent logarithmically on cytocrit. However, MAV was slightly greater for leukemic cells than for red cells at cytocrits up to 20%. At cytocrits above 20%. MAV of leukemic cells increased more rapidly than that of erythrocytes. For example, at a 15% cytocrit MAV(WBC) (1.85 centipoise) was only slightly greater than MAV(RBC) (1.59); whereas, at 45% cytocrit MAV(WBC) (14.9) was markedly greater than MAV(RBC) (3.81). The blood of subjects with leukemia with marked elevation of leukocyte concentration (leukocrits of 6-32%) had 24% higher mean MAV (3.72) than blood with a similar total cytocrit composed of red cells (3.00). A negative correlation was present between leukocrit and erythrocrit in chronic lymphocytic (r = - 0.82) and chronic granulocytic (r = - 0.81) leukemia. Therefore, the modest increase in whole blood MAV in leukemia can be explained by (a) the negative association of leukocrit and erythrocrit and (b) the rarity of leukocrits over 20% and total cytocrits over 45%. However, the MAV of blood of leukemic patients was 71% greater than expected on the basis of their packed red cell volume. Hence, the ratio of hemoglobin concentration (O(2) carrying capacity) to MAV was abnormally low in the subjects with leukemia studied. Individual leukemic leukocytes were nearly rigid. The mean deformability index (DI) of leukemic myeloblasts (1.22; 1.18) and lymphocytes (1.22; 1.40) as measured by filtration and elastometry, respectively, at 50 mm H(2)O negative pressure, approached that of a rigid body (1.0) as compared to red cells studied by filtration (3.09) or elastometry (4.23). The ability of leukemic cells to traverse nucleopore filter or micropipette channels was related to cell diameter. The relevance of the rheology of leukemic cells to the interruption of blood flow and of tissue oxygen delivery and thereby to clinical manifestations of leukemia is considered.


The mechanism of cross-protection afforded by dengue virus against West Nile virus in hamsters. The protection afforded by similar concentrations of different dengue virus serotypes against a subsequent challenge of West Nile virus was studied in hamsters. The New Guinea C strain of dengue 2 virus gave the best protection. It was found that the anamnestic neutralizing antibody response induced by the challenge West Nile virus against West Nile virus in hamsters, previously immunized with dengue 2 virus, might play a major role in the cross-protection observed in this system.


Autonomous erythropoiesis during erythroblastic crisis of chronic myelocytic leukemia. Two patients with chronic myelocytic leukemia who developed an erythroblastic rather than a myeloblastic phase were studied with respect to whether or not the megaloblastic erythropoiesis was subject to normal control mechanisms. After transfusion, no significant reduction was observed in the percentage of nucleated erythroid precursors or of proerythroblasts in marrow or in blood reticulocytes. In one of the two patients, ferrokinetics and urinary erythropoietin levels were studied and were also compatible with the conclusions that erythropoiesis was autonomous in this rare syndrome. Three patients with clinical pictures compatible with Di Guglielmo's syndrome were studied as controls. As has been reported previously, erythropoiesis in this syndrome appeared to be responsive to normal control mechanisms. These data suggest that these two clinically similar syndromes, erythroblastic crisis of chronic myelocytic leukemia and Di Guglielmo's syndrome may represent qualitatively different defects in hematopoietic stem cells.


Toxoplasma antibodies in the sera of immigrants to the United Kingdom from Asia and East Africa. Sera from 203 Asian immigrants to the United Kingdom were examined for toxoplasma antibodies. The antibody titres were not significantly different from those found in the indigenous population although there was some indication that a higher domestic animal-human contact in Asia was associated with a higher positivity rate.


The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. The intranasal inoculation of volunteers with living partially attenuated strains of influenza A and B viruses offers a new opportunity to determine the protective effect of serum haemagglutin-inhibiting antibody against a strictly homologous virus, under conditions where the time and dosage of the infective challenge can be controlled, the scoring of proven infections can be more precise and higher rates of infection can be achieved than in most natural epidemics.In 1032 adult volunteers, whose serum HI antibody titre was determined immediately before virus challenge, there was a consistent inverse quantitative relationship between the HI titre and the likelihood of infection. The PD 50 (50% protective dose) of HI antibody was 1/18-1/36, but an unusual finding was that volunteers with no detectable pre-challenge antibody often seem to be less susceptible to infection than those with pre-challenge antibody in low titre.In one group of volunteers challenged with an influenza B strain there was no evidence that pre-challenge antibody titres against viral neuraminidase had any significant protective effect against challenge infection.


Methadone plasma level: sustained by a reservoir of drug in tissue. Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance treatment; it would be safer when taken in a single dose and longer in its duration of action when taken on a regular schedule.


Stability of cytoplasmic messenger RNA in HeLa cels. The metabolic stability of pulse-labeled or long-term labeled messenger RNA (mRNA) from cytoplasmic free polysomes was measured in HeLa cells, with chase conditions that do not involve inhibitors of RNA synthesis, and chromatography on benzoylated-DEAE-cellulose or poly(T)-cellulose for isolation of mRNA. For these studies, a new chase technique was developed that allows analysis of the stability of mRNA labeled during a short [(3)H]uridine pulse. Pulse-labeled and long-term labeled mRNA were found to decay with an estimated average half-life of about 2 and 3 days, respectively, much longer than hitherto assumed.


The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A. The magnetic susceptibilities of cobalt(II) and nickel(II) derivaties of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 +/- 0.15 and 2.53 +/- 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.


Bromodeoxyuridine dependence--a new mutation in mammalian cells. When cells of a Syrian hamster melanoma were grown in increasing concentrations of bromodeoxyuridine (BrdU), lines of mutant cells able to grow well at high concentrations of BrdU were isolated. The mutant cells were characterized by BrdU dependence. In the absence of BrdU, the cells grew very poorly. The requirement for BrdU was specific for both the bromine and the deoxy sugar. The mutant cells incorporated BrdU into the DNA, replacing about 50% of the thymine residues with bromouracil. The reason for the BrdU dependence is not known.


Changes in alkaline ribonuclease activity during compensatory renal growth. Unilateral nephrectomy in rats produces an increase in ribonuclease activity in both nuclear and cytoplasmic fractions of the contralateral kidney. The timing of this increase and the changes in the proportion of free activity to protein-bound activity are different in each fraction. A peak in inhibitor-bound ribonuclease, suggesting a higher amount of inhibitor, was found in the cytoplasmic fraction before the increase in RNA/DNA ratio. Ninety-six hours after the operation, ribonuclease was still significantly increased in both the nuclear and cytoplasmic fractions. The inhibitor-bound activity was increased in proportion to cellular RNA, maintaining a ribonuclease activity per mug of RNA similar to the controls.


A frequency-dependent natural selection model for the evolution of social cooperation networks. A model is presented for the evolution of several aspects of sociality based on reciprocal ties of social cooperation, modeling especially cooperative hunting behavior in carnivores. This model captures the possibility of a critical threshold in gene frequency, which, if reached, will lead to an explosion toward fixation of the "social" trait. This threshold phenomenon might be restated as follows: the precondition for evolution favorable to the specific form of social behavior considered is hard to satisfy, but-once this condition is satisfied-the tendency toward sociality is effectively irreversible. The simple model proposed appears to be highly robust, with most realistic changes additionally favoring the social gene.


Translational control of specific uterine protein synthesis after estrogen induction. The rate of leucine incorporation into a specific estrogen-induced protein of immature rat isolated by gel electrophoresis declines rapidly between 2-4 hr after estrogen stimulation in vivo followed by incubation in vitro. Actinomycin D present during the in vitro phase prevents this decline, and elicits a "superinduction" effect at 2 hr. Labeled induced protein remains stable during this time period, indicating that its decline is due to a reduction in synthesis capacity for the inducible protein, rather than to its degradation. A second injection of hormone at 3 hr has no effect on the reduced level of synthesis capacity for induced protein noted at 4 hr in the rat uterus.


Inactivation system of the mammalian X chromosome. In female mammals, one of the two X chromosomes present is inactivated during early development. In marsupials, the paternal X is inactivated; in eutherians, one of the two X chromosomes is inactivated at random. A mechanism is proposed to explain the cytogenetic data on inactivation and the derivation of the eutherian system from the marsupial system. In the marsupial system, a site on the X chromosome is sensitive to paternal origin: when the X chromosome is of maternal origin, this sensitive site is responsible for influencing an adjacent site, the receptor, to maintain the X in an active state; the paternal X becomes inactive. Transposition of the sensitive site to an autosome in eutherians would have two consequences. Since the receptor site of the X chromosome is no longer adjacent, the autosomal sensitive site of maternal origin would activate an X at random. The number of active X chromosomes would conform to the number of maternal sensitive sites and thus, generally, to the number of maternal sets of autosomes. The response of the sensitive site to its passage through the male may be designated as imprinting, a term used by Crouse to indicate that the behavior of Sciara chromosomes is determined by parental origin.


Estimation of light-chain gene reiteration of mouse immunoglobulin by DNA-RNA hybridization. A 12S species of RNA has been isolated from membrane-bound polyribosomes of MPC-11 mouse myeloma cells. This 12S RNA is translated by an extract of Krebs-II mouse ascites cells into immunoglobulin light chain. Labeled 12S RNA has been prepared by incubation of myeloma cells with [(3)H]uridine in the presence of low concentrations of actinomycin D and ethidium bromide. This RNA has been hybridized under conditions of DNA excess to mouse myeloma DNA and to liver DNA. A C(0)t(1/2) of about 150 has been obtained, corresponding to a reiteration frequency of about 40. Unlabeled 12S RNA competes with the labeled species in hybridization experiments, whereas globin mRNA or mouse ascites 12S RNA does not. It is suggested that 12S RNA hybridizes only to V(kappa)-genes of the same subclass, and that there may be several hundred genes coding for V(kappa)-regions of all subclasses in a mouse genome. Moreover, gene amplification in myeloma cells is not detected.


The contribution of the alpha and beta chains to the kinetics of oxygen binding to and dissociation from hemoglobin. A new type of experiment in which hemoglobin is exposed briefly to oxygen has shown that the half-time of dissociation of oxygen from some partly oxygenated intermediates is about 1 msec at 20 degrees and 10 msec at 2 degrees . The rapid dissociation occurs selectively from one type of chain, provisionally identified as the beta-chain. Chains that show the rapid rate of dissociation of oxygen also bind rapidly. It follows that the kinetic equivalent of the Adair equation and the Monod-Wyman-Changeux model are quite unsuited to represent the kinetics of the oxygen-hemoglobin reaction. The reaction of oxygen with hemoglobin closely resembles that of the alkyl isocyanides and differs radically from that of carbon monoxide.


Self-complementarity of terminal sequences within plus or minus strands of adenovirus-associated virus DNA. At least 70% of plus or minus strands of adenovirus-associated virus DNA contain self-complementary sequences at or near their termini. Self-annealing of these sequences generates circular molecules that are closed by duplex, hydrogen-bonded segments. The self-annealed segments are sensitive to exonuclease III and have a thermal stability comparable to that of double-stranded DNA molecules. Length measurements of double-stranded adenovirus-associated virus DNA molecules show a bimodal distribution, with the larger component being 10% shorter than SV40 DNA. The presence of self-complementary terminal sequences in single-stranded molecules of viral DNA has been observed previously only with DNA from adenoviruses. It is thus especially notable that adenovirus-associated virus replication is unconditionally dependent on a helper adenovirus. A possible role for terminal self-complementary sequences in viral DNA replication is suggested.


An alteration in glucose metabolism associated with a defect in ketone body metabolism. Skin fibroblasts (CC-69) cultured from a patient with a unique syndrome of ketoacidosis associated with coenzyme A transferase (EC 2.8.3.5) deficiency showed an altered pattern of carbohydrate metabolism. These cells used glucose at a rate significantly less than controls (125 against 680 nmol/mg per hr). The oxidation of [6-(14)C]glucose to (14)CO(2) by these cells was also significantly diminished (12 against 350 pmol/mg per hr), but [2-(14)C]pyruvate and [1,4-(14)C]succinate oxidation by these cells did not differ from that by control cells. Measurements of glycolytic intermediates showed a reduction of several intermediates in the CC-69 cells that confirmed an inhibition of glycolysis between fructose-1,6-bisphosphate and pyruvate. The apparent inhibition in these cells could be reversed by an extended incubation of the cells in a buffered glucose solution. After 18 hr of incubation in 2.5 mM glucose, glucose uptake by the CC-69 cells increased 20-fold to 2560 nmol/mg per hr, whereas the rate for control cells remained constant at 640 +/- 90. Concomitant with this increase, [6-(14)C]glucose oxidation rose from 8 to 2261 pmol/mg per hr while controls remained constant at 428 +/- 175. This change was not due to new enzyme formation because incubation with puromycin had no effect on the increased use of glucose. Mixing experiments demonstrated no transfer of a permeable inhibitor or activating substances. In view of the deficiency of coenzyme A transferase in these cells, the data suggest an indirect regulatory role for this enzyme in peripheral tissue glycolysis.


Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes. This study describes the kinetic properties of N-acetyl-D-galactosaminyltransferase in serum from subjects with blood groups A(1) and A(2). When the A(1) and A(2) enzymes were compared, with lacto-N-fucopentaose I and 2'-fucosyllactose as acceptors, the enzymes differed in their cation requirements, pH optima, and K(m) values. The two acceptors competed for the same transferase. Mixing experiments showed that the lower activity of the A(2) enzyme could not be attributed to a modifier or inhibitor in serum. It was concluded that the A(1) and A(2) enzymes differ qualitatively.


Weaver mutant mouse cerebellum: defective neuronal migration secondary to abnormality of Bergmann glia. Previous work showed that in cerebella of mice homozygous for the autosomal mutation weaver, wv, most postmitotic granule cell neurons die during the first 2 weeks after birth close to their site of genesis in the external granular layer. Analysis of the less severely affected heterozygotes by electron microscopy and autoradiography indicates that granule cell death occurs several days after cell genesis and is secondary to failure of their somas to migrate across the molecular layer to the granular layer. This migration defect in turn appears secondary to a hitherto unrecognized disorder of Bergmann glial cells, the cells that normally guide the young neurons in their migration. In +/wv cerebella, Bergmann glial processes are enlarged and irregular in caliber, electronlucent, and often vacuolated; in wv/wv, Bergmann cell processes are almost absent. The primary genetic abnormality remains undefined, but the gene dosage effect, here recognized at a cellular level for the first time in a mammalian neurological mutant, suggests that even though neuronal death serves as the most prominent and clinically relevant phenotypic expression, the Bergmann glial abnormality may actually be closer to the primary cellular target of the wv genetic locus.


Inhibition of reticulocyte peptide-chain initiation by pactamycin: accumulation of inactive ribosomal initiation complexes. Pactamycin does not inhibit the overall initiation factor- and GTP-dependent binding of [(35)S]Met-tRNA(f) to rabbit reticulocyte ribosomes but does prevent the formation of Met-puromycin, provided that the antibiotic is present during the course of the binding reaction. These data indicate that pactamycin blocks the synthesis of a functional peptide-chain initiation complex. Sucrose density gradient centrifugation analysis of binding reactions shows that pactamycin causes the accumulation of an initiation complex on the smaller ribosomal subunit (smaller initiation complex), to which the 60S ribosomal subunit either cannot join or with which it forms a larger inactive 80S initiation complex that falls apart under the conditions used for isolation. The smaller initiation complex formed in the presence of pactamycin differs from the normal intermediate in peptide-chain initiation in being much more resistant to degradation by pancreatic RNase. In the presence of pactamycin, the inactive smaller complex can also form on mRNA to which an unaffected ribosomal couple is already attached, forming an oligoribosome lacking a larger ribosomal subunit or a "1.5 mer." These effects of pactamycin can be overcome to a considerable degree by elevation of the Mg(2+) concentration.


Experimental differential light-scattering correction to the circular dichroism of bacteriophage T2. Experimental techniques are presented that can be used to assay and correct for differential light scattering effects in circular dichroism spectra of biological macrostructures. The assay is based upon use of variable detector geometries that collect light over large solid angles. Disrupted T2 virus suspensions and purified T2 phage DNA exhibit geometry-independent spectra; the spectrum of intact T2 virus is highly sensitive to detection geometry. On the basis of spectra obtained after light-scattering correction, the structure of T2 DNA in the phage particle is assigned to the C form. We conclude that: (i) The measured circular dichroism of a light-scattering specimen may be highly sensitive to light-detection geometry of the instrument. This effect is indicative of differential scattering intensity for left and right circularly polarized light. (ii) Some optically active particles, although they scatter light intensely, exhibit circular dichroism that is independent of detection geometry and, therefore, apparently uninfluenced by differential light scattering. We infer that whether differential light scattering arises may depend upon the presence or absence of ordered asymmetry in the organization of the scattering particle. (iii) The circular dichroism of any light-scattering specimen should be measured again in apparatus designed for differential light-scattering correction as a prerequisite to meaningful structural conclusions. (iv) Differential scattering effects in circular dichroism may be potentially useful as a probe for large-order organization of the scattering particle.


In vitro assembly of bacteriophage Lambda heads. The assembly of plaque-forming particles in cell-free extracts of induced lambda lysogens was observed two ways. (i) DNA isolated from a lambda-related phage, 434 for example, is added to an extract of an induced lambda lysogen, and plaque-formers with the genotype of the added DNA are detected. (ii) One extract from an induced lambda lysogen that carries an amber mutation in one of the head genes (A, B, C, D, or E) is mixed with one carrying an amber mutation in a different head gene; an increase in the number of lambda plaque-formers is found over that in either extract alone. These plaque-forming particles have the properties of normal phage particles. They are resistant to DNase, although DNase added to an extract before addition of DNA prevents their appearance; they have a sensitivity to neutralizing antibody and a specificity of adsorption to bacteria characteristic of the source of the extract, but they have the genotype of the added DNA; and they have about the same bouyant density as phage particles. Mutants in genes B, C, or D can donate DNA to the phage formed by complementation between extracts of different mutants, but mutants in genes A or E cannot. Complementation occurs between a pair of extracts only if one (or both) is a DNA donor. This observation suggests a tentative pathway for head assembly: that the products of genes A and E act before those of B, C, and D.


Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. Squalene and sterol carrier protein of liver plays a general role as a vehicle for cholesterol and its water-insoluble precursors; the carrier protein is essential for enzymic cholesterol synthesis. Liver microsomal enzymes contain a small amount of endogenous carrier protein, which is readily removed by washing or purification of the enzyme. Enzymic conversion to products of a cholesterol precursor.carrier protein complex is markedly faster than that for initially unbound sterol. The protomer form of the carrier protein has a molecular weight of 16,000; during sodium dodecyl sulfate gel electrophoresis one band is observed. Phospholipid facilitates the aggregation of the protomer to the oligomer form (>150,000 daltons; purified 720-fold) accompanied by the binding of cholesterol precursors to the oligomer. The carrier protein binds fatty acids as well as cholesterol precursors, suggesting that it may more generally be a lipid carrier protein with "squalene and sterol carrier protein" describing the functional aspects of the lipid carrier in cholesterol biosynthesis. Studies with several steroids and related compounds revealed that the binding sites of lipid carrier protein must contain highly specific hydrophobic and polar regions.


Development of acetylcholine receptor clusters on cultured muscle cells. Clusters of acetylcholine receptors were formed in the absence of neurons during the development of cultured chick-embryo skeletal muscle cells. The average concentration of receptors in clusters was estimated to be 9000 per mum(2). At other regions of the cell, receptor concentration was 900 per mum(2). The possibility that receptor clusters may participate in synapse formation is suggested.


Human lymphotoxin: purification and some properties. Lymphotoxin is secreted by human lymphocytes stimulated with phytohemagglutinin in vitro. Combinations of DEAE-cellulose and Sephadex chromatography, acrylamide gel electrophoresis, and isoelectric focusing were used to purify lymphotoxin 2000- to 4000-fold; 15-25% of the activity has been recovered. Lymphotoxin appears to be a weakly charged molecule(s) of molecular weight about 90,000-100,000 that migrates in Pevikon block electrophoresis as a beta- or alpha2 globulin. It is a discrete molecule(s), because it is completely separable from medium serum proteins and carrier and phytohemagglutinin proteins. Isoelectric-focusing studies indicate that there may be a limited heterogeneity among lymphotoxin molecules.


Structure and development of neuronal connections in isogenic organisms: variations and similarities in the optic system of Daphnia magna. It is readily apparent upon examination and comparison of organisms of the same and related species that to a large extent genes control morphological features. One means to ascertain the role and degree of genetic control is to study in detail the anatomy and development of a particular structure, say an identifiable neuron, in a population with a fixed genome, and at different stages of morphogenesis. The small crustacean, Daphnia, is well suited for this type of study, since it reproduces parthenogenically, its development is easily staged, and its nervous system is reasonably simple. In this paper comparisons of detailed morphology of neurons in the visual system of adult Daphnia magna are considered. Results indicate that gross features of the system are reproduced within the clone, but some of the finer details are not reproduced.


On the theory of ion transport across the nerve membrane, VII. Cooperativity between channels of a large square lattice. The exact kinetics of a 10 x 10 Ising system (periodic boundary conditions) with two-state channels arranged in a square lattice was studied by computer simulation. With all three values of the cooperativity parameter used, no induction in the K(+)-current curve was obtained. This confirms one of our previous conclusions concerning K(+) channels in the squid axon membrane: models with interacting channels arranged in a twodimensional lattice (Adam's model) are apparently excluded. Other topics included: equilibrium properties; short-range pair correlation functions; phase transition.


Protein initiation in eukaryotes: formation and function of a ternary complex composed of a partially purified ribosomal factor, methionyl transfer RNA, and guanosine triphosphate. A protein factor contained in a 1 M KCl extract of L-cell ribosomes and partially purified by chromatography on DEAE-cellulose forms a specific ternary complex with rat-liver Met-tRNA(f) and GTP. The complex is measured by its quantitative retention on nitrocellulose membranes. Complex assembly is optimal at 100 mM KCl and 0.2 mM MgCl(2), and is independent of mRNA and of ribosomes. The GTP requirement can be replaced over 65% by its methylene analogue GDPCH(2)P, indicating that GTP hydrolysis is not involved. Complex formation is inhibited by 10 muM aurintricarboxylic acid, but is unaffected by 100 muM pactamycin, 100 muM fusidic acid, or by excess uncharged methionine tRNA(f). The ternary complex is relatively stable and appears at the void volume during filtration on Sephadex G-100. At 1-3 mM MgCl(2) and in the presence of other factors, the ternary complex is implicated in protein initiation by (i) its capacity to bind to the 40S ribosomal subunit to form a 48S complex; and (ii) the subsequent association of the 48S complex with a 60S subunit to form a functional "80S complex."


Stimulation of mitochondrial adenosine diphosphate uptake by thyroid hormones. Thyroid hormone administered in vivo increased carrier-mediated (atractyloside-sensitive) ADP uptake by rat liver mitochondria. 3 Days after a single large dose of triiodothyronine (20 mug/100 g of body weight), mitochondrial uptake of ADP measured at 6 degrees was 2.35 +/- 0.17 nmol/min per mg of protein, compared with an uptake of 1.81 +/- 0.19 nmol/min per mg of protein in mitochondria from untreated rats (P < 0.025). Cyanide (1.33 mM) had no effect on ADP uptake by mitochondria from either untreated or triiodothyronine-treated animals. Uptake of ADP by mitochondria from thyroidectomized rats treated with thyroxine for 7 days was 2.89 +/- 0.40 nmol/min per mg in mitochondria from thyrotoxic rats (20 mug of thyroxine per 100 g per day) and 1.98 +/- 0.22 nmol/min per mg in mitochondria from euthyroid rats (2 mug of thyroxine per 100 g per day) (P < 0.025). Mitochondria from both untreated and thyroid hormone-treated rats displayed a highly significant linear correlation between ADP uptake and ADP-dependent (i.e., state 3 minus state 4) oxygen consumption. There was, however, no difference in respiratory control ratios between mitochondria from euthyroid and thyrotoxic animals. Administration of dinitrophenol (2 mg/100 g) also stimulated carrier-mediated ADP uptake, but respiratory control of mitochondria from dinitrophenol-treated animals was virtually abolished. Triiodothyronine in vitro, at concentrations of 100 and 0.1 nM, appeared to inhibit rather than stimulate the uptake of mitochondrial ADP. The relationship between these observations and the clinical manifestations of thyrotoxicosis is discussed from the point of view of the possible effects of increased mitochondrial ADP transport on oxidative phosphorylation and adenosyl nucleotide metabolism.


Ethanol-insoluble adenine nucleotides in platelets and their possible role in platelet function.


Characterization of tumor cell populations by DNA-measurements.


Recent advances in platelet lipid metabolism research.


Nuclear dry mass and area variations in human buccal mucosa cells.


Thrombosthenin: structure and function.

Thrombosthenin: structure and function.


Platelet adhesion.

Platelet adhesion.


Cytologic diagnosis of salivary gland lesions in adult and pediatric surgical patients.


A case of secondary echinococcosis diagnosed by cytologic examination of pleural fluid and needle biopsy of pleura.


Qualitative platelet disorders: classification and pathogenesis.


Platelet-function studies in the Bernard-Soulier syndrome.


Oral cytology. Seven year oral cytology screening program in the State of Rhode Island. Analysis of 6448 cases.


Ultrastructural defects in congenital disorders of platelet function.


Abnormalities in the platelet-collagen reaction.


The detection of vaginal adenosis and clear cell carcinoma.


The effect of dialysis on platelet function of patients with renal failure.


Abnormalities of platelet aggregation in patients with alcoholic cirrhosis.


Platelet defects in the myeloproliferative disorders.


Cytologic changes in the oral cavity of reverse smokers.


A simplified evaluation of vaginal cytology in third trimester pregnancy complications.


Factors affecting hemostatic plug formation in an extracorporeal model.


Platelet dysfunction in preleukemic states and in various types of leukemia.


The role of convection and diffusion on platelet adhesion and aggregation.


A three-dimensional view of platelet responses to chemical stimuli.


Regulation and mechanism of platelet aggregation.


Intrinsic platelet defects in hereditary thrombocytopenia.


Current ideas on the mechanism of platelet aggregation.


The platelet defect associated with albinism.


Lipid and amino acid synthesis in aggregating platelets.


Platelet interaction with fibrinogen and fibrin: comparison of the interaction of platelets with that of fibroblasts, leukocytes, and erythrocytes.


Incidence of dry socket complication in third molar removal.


Clinical and bacteriologic aspects of polyglycolic acid sutures.


Simplified method of fixation after segmental orthodontic surgery.


Metastatic tumors to the mouth: report of two cases.


Myxoma of the maxilla: report of case.

Myxoma of the maxilla: report of case.


Solitary intraosseous neurofibroma involving the mandibular canal: report of case.


Management of condylar fractures in patients with cervical spine injury: report of cases.


Correction of extreme dilatation of Stensen's duct resulting from chronic partial obstruction.


Facial neuralgia caused by unrecognized foreign bodies: report of case.


Fractures of the zygomatic complex: an evaluation of surgical management with special emphasis on the eyebrow approach.


Training of the oral surgery assistant.

Training of the oral surgery assistant.


Correlation between the development of an oroantral fistula and the size of the corresponding bony defect.


The halothane dilemma.

The halothane dilemma.


Hygiene standards for cotton dust. British Occupational Hygiene Society Committee on Hygiene Standards Sub-committee on Vegetable Textile Dusts.


The physiological requirements for self-rescuers related to the performance of existing apparatus.


Marine antifouling compositions and their applications.


The dental nurse.

The dental nurse.


Maxillary block anesthesia.

Maxillary block anesthesia.


Surgical treatment of a case of mandibular prognathism.


Factors affecting dental educational progress.


New trends in dental education.

New trends in dental education.


Ends and means in dental education.

Ends and means in dental education.


Vibration perception in teeth during cavity preparation.


Psychological defense mechanisms in dentistry.


The influence of some surface-active substances on decalcification of enamel surface.


Principles and professional practice.

Principles and professional practice.


Education in the health sciences in South Pacific.


Experimental studies on tooth deformation: stress distribution in class V restorations.


Modern class 2 amalgam cavity preparations.


Denture sore mouth and nutritional deficiency.


Social security: the Royal Commission.

Social security: the Royal Commission.


A study of the permeability of gingiva using intravenous colloidal thorium dioxide.


Scanning electron microscopy of carious enamel.


Prevention of pit and fissure caries: 1. The microscopic appearance of occlusal sealants within fissures.


Concerning the biosynthesis of vitamin B12.


The frequency of patients with disorders associated with alcoholism in mental hospitals and psychiatric departments in general hospitals in Sweden during the period 1954-1964.


Tear cholesterol levels and contact lens adaptation.


Mechanisms subserving surface and border brightness contrast.


Ghost imagery intensity and durability of selected anti-reflectant coatings.


Gonioscopy for optometrists.

Gonioscopy for optometrists.


Visual field related to test target size and illuminance.


Common factors in contact lens failure.

Common factors in contact lens failure.


The effect of correction of severe long-standing refractive errors on the mental status of psychotic patients.


Modified surgical binoculars for use in contact lens practice.


Optometric visual training for reading disability. A case report.


Neuroleptanalgesia for neurosurgical patients undergoing cordotomy and rhizotomy.


Peracetic acid as sterilizing agent for culture serum.


Continuous negative pressure in the management of severe respiratory distress syndrome.


Characteristics of nonepithelial cells in the epithelium of normal rat ileum.


Forty-seven year old woman with dyspnea and multiple nodules in the lung fields.


The effects of instrumentation on gas flows during bronchoscopy using the Sanders ventilating attachment.


Diagnostic tests in alcoholism.

Diagnostic tests in alcoholism.


Absence of recurarization upon rewarming.


A ventilating bronchoscope for inhalation anesthesia and augmented ventilation.


Attitudes regarding alcoholism: the volunteer alcoholism clinic counsellor.


Bout and continuous drinking in alcoholism.


Total alcohol consumption as an index of anxiety among urbanised Africans.


The influence of alcohol on the mood of the alcoholic.


Two years' experience of group methods in the treatment of male alcoholics in a Scottish mental hospital.


The heroin-marijuana relationship: a basic aspect of drug management.


Milieu management for drug addicts: extended drug subculture of rehabilitation?


The three types of marijuana dependencies.


Temporal lobe epilepsy due to drug withdrawal.


Ethical and social-psychological aspects of urinalysis to detect heroin use.


Drug abuse--prevention through education at school.


Taste thresholds in drug addicts and alcoholics.


Social characteristics of addiction to heroin.


'Antigenic' disparity between leukaemic lymphoblasts and normal lymphocytes in identical twins.


Massive breast involvement in acute leukemia. Case report.


The hypocalcemic effect of glucagon in cases of hypercalcemia.


Bringing order to a patient's medical packet.


Uterine tumor mimicking Meigs's syndrome (intractable heart failure).


Rhabdomyolysis. Two case reports and a review.


Factors in the development of drug addiction.


Lag in physical development during adolescence.


Postprandial T-wave changes. Relationship to serum potassium, age, and exercise electrocardiograms.


Arthritis as a manifestation of various disease states.


Orthopedic resident training program.

Orthopedic resident training program.


The many worlds of today's physician.

The many worlds of today's physician.


Is low blood sugar necessary?

Is low blood sugar necessary?


Treatment of poisonous snakebite.

Treatment of poisonous snakebite.


Ocular findings in head trauma.

Ocular findings in head trauma.


BCG and cancer.

BCG and cancer.


Pre-hospital emergency care of the heart attack patient.


Choledochal cyst, use of rose bengal scan in diagnosis.


Non-seasonal allergic rhinitis.

Non-seasonal allergic rhinitis.


The hospital as a community facility. The hospital: a changing perspective.


The hospital as a community facility. Rising hospital costs: possible causes and cures.


The hospital as a community facility. Hospital services: needs and costs.


The hospital as a community facility: the medical staff and the hospital.


The hospital as a community facility. Community service, the medical staff, and the hospital: a house officer's views.


The hospital as a community facility. The medical staff and the hospital: an organizational perspective.


The hospital as a community facility: the hospital.


The hospital as a community facility: effectiveness and efficiency in hospital management and the interdependence of health services.


The hospital as a community facility. Cooperation of hospitals in Canada: regionalization, mergers, and shared services.


The hospital as a community facility. Hospitals: isolated or interdependent?


The hospital as a community facility. Teaching hospitals: alone or together?


The hospital as a community facility: what gives meaning to the interdependence of hospitals?


The hospital as a community facility: standards in health care.


The hospital as a community facility: a single standard of care.


Improvement of chest roentgenography by respirator-controlled pulmonary inflation.


A mathematical model of the cell cycle of L5178Y.


Cytogenetic studies in myeloproliferative disorders.


Studies on the consecutive survey of succedaneous and permanent dentition in the Japanese children. 7. Approximate alveolar eruptive periods for the normal successors.


Cephalometric considerations of the upper protrusion treatment cases by the edgewise method.


A new production of mini-tomographic apparatus and their testing.


Use of compost instead of chemical fertilizer to avoid fluorine contamination of soil, water, and food.


Has the tradional recovery room lost its usefulness?


A matter of degree.

A matter of degree.


A reappraisal of surgical orthodontics.

A reappraisal of surgical orthodontics.


The experimental use of poly(methyl methacrylate) implants in mandibular defects.


Lateral compression in the treatment of mandibular fractures.


An orthodontist's view of surgical orthodontics.


Origin of the globulomaxillary cyst.

Origin of the globulomaxillary cyst.


Calcifying fibroblastic granuloma.

Calcifying fibroblastic granuloma.


Fever and the postoperative patient.

Fever and the postoperative patient.


Superior orbital fissure syndrome with Bell's palsy: report of case.


Parotid fistula: a complication of mandibular osteotomy.


Developmental submandibular gland defect of the mandible: review of the literature and report of two cases.


Skeletal relapse during intermaxillary fixation.


Gastrin: a review.

Gastrin: a review.


Evidence of chronopathology in alcoholism.


Psychiatric aspects of Addison's disease: report of a case.


Unusual metastases from a transitional-cell carcinoma of the renal pelvis and ureter.


Repository injection of allergens. Study of safety aspects.


Sodium tyropanoate. Evaluation of new oral cholecystographic agent.


Solitary plasmacytoma of sternum.

Solitary plasmacytoma of sternum.


Pulmonary complications of gastroesophageal reflux.


Malignant tumors with superior vena cava obstruction.


Congenital venous aneurysm of superior mediastinum.


Aneurysm of aberrant right subclavian artery. Rare cause of superior mediastinal tumor.


Coarctation of aorta associated with anomalous right subclavian artery and its aneurysm.


Salivary gland disorders. I. Recognition, diagnosis, and treatment.


Jaundice and coma in heroin addiction.

Jaundice and coma in heroin addiction.


Effects of oxandrolone in advanced renal insufficiency. Report of metabolic balance studies.


Inevitable decline of chiropractic.

Inevitable decline of chiropractic.


Gonarthrosis due to Paget's disease of tibia. Treated by modification of high tibial osteotomy.


Patterns of illicit drug use. Among patients in an adolescent medical service.


Young Mothers' Clinic in suburban county hospital.


Effects of L-asparaginase on the two cases of acute leukemia with mediastinal tumors as initial signs.


Intraarterial distribution of colloidal bismuth compounds injected in man.


Toxic property of the phospholipid from Bacterionema matruchotii.


The structural orientation of human cementum determined through form birefringence curve.


Studies on addition of glass filler to adhesive sealant for prevention of dental caries.


How we think--a new attitude for the mind.


Prenatal dental development.

Prenatal dental development.


Your investments.

Your investments.


Rx for a healthy practice.

Rx for a healthy practice.


The New Zealand dental nurse concept: decline and fall of U.S. dentistry?


Do you turn your patients off?

Do you turn your patients off?


An exclusive report from abroad: what is dentistry really like under national health care?


Your office needs a woman's touch.

Your office needs a woman's touch.


Social security questions and answers.

Social security questions and answers.


Practice administration.

Practice administration.


Productivity: what it is, and what it means.


Motivation: quiz lets you compare ideas with expert opinion.


Case report: median mandubular cyst.

Case report: median mandubular cyst.


How the G.P. can treat a 'blunderbuss' canal.


Tooth movement in adults: guidelines for the G.P.


Detecting caries on film without removing bands.


New directions: plotting dentistry's future.


Teaching 'group practice' for tomorrow's dentistry.


Uses of composites for restorations.

Uses of composites for restorations.


Expansion adds room for total dentistry.


Articulators in fixed prosthodontics.

Articulators in fixed prosthodontics.


Students spend summer in mobile unit. Muscatine provides exposure to many cultures.


Age-old problem of cheating still remains--student officers discuss causes and remedies.


Why the growth in costs of dental education.


Dental education and the community: a field experience.


Anteroposterior facial orthopedics in the pedodontic patient.


Evaluation of airborne contamination in a dental school clinic.


Application of neuromuscular function to determine occlusion and rest by visualizing masticatory muscle potentials.


Colorado health consumer survey.

Colorado health consumer survey.


Crystallographic studies of hydroxyapatite and fluorapatite. The effect of fluoride on growth and maintenance of hydroxyapatite crystals.


What I, as a beginning practitioner, expect of organized dentistry.


The utilization of the dental health educator in private practice.


Certain biological considerations in the selection and use of restorative dental materials.


Formocresol: its application in endodontics.


Dentigerous cyst with an inverted mandibular third molar impaction.


Dental public health and postgraduate dental education.


Actinomycosis--an unusual pathogen.

Actinomycosis--an unusual pathogen.


The occlusion of cleft premaxillae with the aid of precision attachments.


The origins of globulomaxillary cyst.

The origins of globulomaxillary cyst.


Medication hazards in dentistry. I.

Medication hazards in dentistry. I.


The prognosis of filled first permanent molars: a preliminary study.


Historical background of dentistry in South Carolina.


The dental student as a teacher.

The dental student as a teacher.


Case report: chloroma (granulocytic sarcoma).


Oral features of primary amyloidosis.

Oral features of primary amyloidosis.


Traumatic defects of the orbital floor.

Traumatic defects of the orbital floor.


The radiological features of odontogenic keratocysts.


Intra-oral condylectomy applied to unilateral condylar hyperplasia.


Partial myotomy in temporomandibular pain dysfunction: a preliminary communication.


Yttrium 90 in the treatment of oral leukoplakia.


Infections of the infratemporal space.

Infections of the infratemporal space.


Multiple sialolithiasis of minor salivary glands: report of a case.


Histiocytosis 'X'.

Histiocytosis 'X'.


Trans-antral approach for the removal of misplaced maxillary third molars in suitable cases.


Periostitis ossificans.

Periostitis ossificans.


Perforation in a case of submucous cleft palate due to an aphthous ulcer.


Tuberculosis of the submandibular salivery gland.


Skeletal open bite associated with bimaxillary dento-alveolar protrusion, evaluation and treatment.


The hole and I.

The hole and I.


Availability--requisite of the professional man.


1972 Annual Report American Fund for Dental Education.


Effective AIOB programs.

Effective AIOB programs.


Malpractice actions.

Malpractice actions.


Dentistry in Australia.

Dentistry in Australia.


Fees for dental speakers.

Fees for dental speakers.


Education courses begin at Pankey Institute.


Dentistry's past and future meet in Egypt.


Tennessee changes admissions system.

Tennessee changes admissions system.


Fluoridation begins in Columbus area.

Fluoridation begins in Columbus area.


Estimated reduction in dental expenditures for Iowans through preventive programs.


Implementation of a three-year, 12-trimester dental curriculum at the New Jersey Dental School--College of Medicine and Dentistry of New Jersey.


Research techniques used in evaluating dental materials.


The effects of saliva contamination on dental amalgam.


Cigarette smoker's lip lesion in psychiatric patients.


Trichinosis in oral musculature: report of case.


Tongue thrust: report of cases.

Tongue thrust: report of cases.


Adenoameloblastoma: report of case.

Adenoameloblastoma: report of case.


A kindred showing hypocalcified amelogenesis imperfecta: report of case.


The diagnosis and treatment of vertical root fractures: report of case.


The "poor prognosis" ectopic first permanent molar: report of case.


Radiation-induced cancer.

Radiation-induced cancer.


Albright syndrome and leukemia.

Albright syndrome and leukemia.


Symptomatology of depressive illness in Afghanistan.


Legal responsibility for professional negligence.


Factors influencing dentists' incomes.

Factors influencing dentists' incomes.


Oral health of Australian aborigines: endemic dental fluorosis.


Epidemiology of periodontal disease in the diabetic and the non-diabetic.


The endodontic management of the acute pulpal or periapical lesion.


Practical aspects of occlusion in restorative dentistry.


Protective effectiveness of a stannous fluoride gel.


WHO and dental caries.

WHO and dental caries.


The ultrastructure of the blood vessels of the human dental pulp following injury. I.


Scanning electron microscope studies of Class II cavity margins. Matrix band application.


An evaluation of lead foil in dental X-ray film packets. 2. The effect of back-scattered radiation on radiographic contrast when the density is maintained at an optimum level.


A practical guide to assisted operating. 3. Instrument handling. 1.


Ankylosis of an unerupted third molar by inostosis of enamel. A case report.


An airway resistance for use in an artificial lung.


Sex-linkage and sex-limitation in quantitative inheritance. II. Diallel crosses.


Selection at the transferrin locus in cropped vole populations.


Urticaria pigmentosa and acute lymphoblastic leukemia.


Medical audits.

Medical audits.


Obesity and some of its management aspects.


Sonic environment and the psychiatric patient.


Some psychological determinants of violence and its control.


Transference in a group with different therapists.


Psychiatric admissions and family size.

Psychiatric admissions and family size.


The "human relations" movement and psychiatry.


Psychiatry and political thought.

Psychiatry and political thought.


Intoxication with procyclidine (kemadrin), report of three cases.


Clinicopathological Conference of the Medical University of South Carolina. Persistent epigastric pain in an alcoholic with chronic pancreatitis and numerous bacteria in gastric aspirate.


The Carolina acupuncturer.

The Carolina acupuncturer.


Nursing service in Guy's Hospital, London.


Papillary carcinoma of the thyroid.

Papillary carcinoma of the thyroid.


Abortion.

Abortion.


Epidemic of echovirus type 9 infection. Certain clinical and epidemiologic features.


Group therapy in obstetric management of pregnant teen-agers.


Phobic anxiety-depersonalization syndrome.


Allergy and heredity. Prospective study.


Role of allergy clinic in community pediatrics program.


Electrocardiograms of the month.

Electrocardiograms of the month.


Methyldopa fever. Recurrence of symptoms with resumption of therapy.


Spontaneous closure of ventricular septal defect. Tricuspid atresia following Waterston's anastomosis.


Metastatic melanoma of ureter.

Metastatic melanoma of ureter.


Massive pulmonary fibrosis due to systemic lupus erythematosus.


Hospital medical staff as a physicians' union.


Routine laboratory tests. Modern physicians' dilemma.


Training health-center administrators. Some alternatives.


Solution to smallpox vaccination dilemma.


Metabolic aspects of the use of medium chain triglycerides in the treatment of obesity.


Function following arthrodesis for coxarthrosis with special reference to the mobile hip.


Local recurrence in primary osteosarcoma of the femur.


Effects of the XYY karyotype in one of two brothers with congenital adrenal hyperplasia.


Vibration syndrome.

Vibration syndrome.


General hospital psychiatry.

General hospital psychiatry.


A bacteriological survey of an operating theatre environment.


An evaluation exercise carried out on fifth year medical students.


The efficacy of school certificate as a criterion for student nurse selection.


Chronic typhoid infection in a normally functioning gall bladder.


Proportionate responsibility.

Proportionate responsibility.


Psychological aspects of the course at outward bound.


National health.

National health.


Fissure-in-ano and haemorrhoids.

Fissure-in-ano and haemorrhoids.


Abortion--a matter of life and death.

Abortion--a matter of life and death.


New Zealand Committee on Adverse Drug Reactions: seventh annual report.


Dietary immunology: an hypothesis.

Dietary immunology: an hypothesis.


Treatment of cardiogenic shock. I.

Treatment of cardiogenic shock. I.


Pulmonary cryptococcosis.

Pulmonary cryptococcosis.


82 year old caucasian married male with an abdominal mass.


Treatment of hypercalcemia with furosemide and corticosteroids.


Family practice residency programs.

Family practice residency programs.


X-ray case of the month.

X-ray case of the month.


Hodgkin's disease. A clinico-pathological study of 250 cases with a 5-year follow-up. Two hundred and fifty cases of histologically proven Hodgkin's disease have been reviewed. These cases were classified according to the Rye Conference histological classification (Lukes et al., 1966a) and according to the Cross classification (Cross, 1969). Overall, both classifications were reasonably effective in predicting prognosis but that of Cross with its seven sub-groups proved more difficult to use than the simpler Rye classification. In all cases the follow-up period exceeded 5 years. A study was made of the influence of clinical symptoms on survival with particular reference to night sweats, fever, pruritus, anorexia, lassitude, weight loss, haematological abnormalities and splenic enlargement. The presence of these abnormalities adversely affected prognosis. The spread of the disease from one group of nodes to the next was also documented. Considering all cases the 5-year survival was 54%. The 5-year survivals according to histological type were: lymphocytic predominance 69%, nodular sclerosis 57%, mixed cellularity 41%, lymphocytic depletion 40%. The 10-year survival was 23% which, when corrected by the actuarial method (Berkson and Gage, 1950), rose to 36%. The importance of symptomatology as well as histological grading in the prognosis of Hodgkin's disease is confirmed.


A study of the carcinogenicity for skin of a polyphenyl coolant.


Hearing conservation.

Hearing conservation.


Renewed efforts to stem workers' accidents urged by ILO.


Proteinuria screening and kidney disease questionnaire in an industrial population.


Development of auxiliary personnel in dentistry for Latin America.


Operating dental auxiliaries.

Operating dental auxiliaries.


Comparison of computer-generated data with actual use of therapists.


Accreditation of specialty programs marks new era in Canadian dentistry.


Self-instructional drug prescribing in dentistry.


Intensified course presentation in teaching complete prosthodontics.


Applying individualized instruction to a dental school environment.


One answer to parochialism.

One answer to parochialism.


Dental students eligible for full tuition military scholarships.


The crunch: Federal Budget for FY 1974.

The crunch: Federal Budget for FY 1974.


Prescriptions in triplicate--a deluge of paper tigers.


Where reciprocity stands today.

Where reciprocity stands today.


State society meets with officials of United Federation of Teachers. A report.


An obscure habit and its resulting malocclusion.


Ventilation of a lung model with the Engström respirator. The effect of different respirator settings on gas distribution.


A volume and pressure controlling spill valve equipped for removal of excess anaesthetic gas.


Surgical-orthodontic correction of mandibular prognathism.


Surgical-orthodontic treatment of severe mandibular retrusion. II.


Clinical treatment with the Begg appliance.


AAO constituent society presidents discuss current orthodontic issues. I.


American Association of Orthodontists. Phase 3 bulletin.


Pulmonary edema and hemorrhage resulting from cerebral compression.


Preventive dentistry--challenge to dental education.


Histamine formation from  14 C-L-histidine in man. 1. (14)C-L-histidine was given i.v. to one normal subject and two patients with chronic myelocytic leukaemia. Urinary excretion of histamine and two of its metabolites methylhistamine and methylimidazoleacetic acid, total as well as (14)C-labelled, was measured, as well as blood (14)C-histamine. In addition the total urinary and pulmonary elimination of (14)C was followed.2. Total (14)C elimination was high during the first days, then declined slowly except for a plateau at the 10th-14th day in the two patients. There was a measurable elimination even after some months.3. (14)C-histamine appeared in the blood of the leukaemic patient, whereas in the normal subjects the values were hardly measurable.4. The leukaemic patients excreted much more of the two (14)C-labelled histamine metabolites than the normal subject. The difference in excretion of the (14)C-labelled metabolites was largest around the 12th day after the infusion of (14)C-L-histidine.5. The results indicate that the leukaemic patients formed at least 20 times more histamine daily than the normal subject.


The fine art of understanding patients through nutrition counseling.


Patient irresponsibility: no excuse.

Patient irresponsibility: no excuse.


The influence of personal dental care in periodontics.


The prevention and control of periodontal disease.


The advantages of early orthodontic treatment.


The dental student and preventive dentistry.


More schools go to three-year programs.

More schools go to three-year programs.


A new clinic teaches students to teach plaque control.


Background and appraisal of the dental vaccine.


Mercury vapor: a hazard in the dentist's office.


Diabetes in dentistry.

Diabetes in dentistry.


Now, a union for dentists?

Now, a union for dentists?


Students get a voice in organized dentistry.


Dental auxiliaries and the poor: a study of expressed willingness to serve.


A plan to bring dental care to world's needy.


What is the ideal form of student government?


Dental hygiene, new part-time job for dental students.


One-appointment technic using an adhesive composite.


Pulpotomy technic to save abscessed deciduous teeth.


Composite build-up offers advantages in crown procedures.


Keeping your staff involved.

Keeping your staff involved.


Preventing and correcting personality problems with timely treatment.


Patient "isolation" yields to open look.


Follow-up helps salvage the "lost" treatment conference.


Survey of dental assistants.

Survey of dental assistants.


Esthetics and anterior function. 2 case reports.


Dental x-rays: a justifiable public concern?


The role of the private practitioner in preventing SBE: a variation in the antibiotic coverage of penicillin-sensitive patients.


Zinc and surgery.

Zinc and surgery.


Flossing--does it really work?

Flossing--does it really work?


Passavant's pad and its relationship to obturator bulb placement.


How to avoid the problems in interceptive treatment.


Survival of the fittest.

Survival of the fittest.


Orthodontics and its problems.

Orthodontics and its problems.


Hare lip and cleft palate in Ireland.

Hare lip and cleft palate in Ireland.


A survey of dental treatment in New Jersey Prisons.


The oral surgeon and the general practitioner: a difficult relationship.


Normal and abnormal palatal development.


Auxiliaries in the office laboratory.

Auxiliaries in the office laboratory.


Hypertension detection by dentists.

Hypertension detection by dentists.


Patients' complaints.

Patients' complaints.


Extraction of a tooth during a dog attack. Case report.


Oral tissue temperature variations.

Oral tissue temperature variations.


Apical sealing procedures.

Apical sealing procedures.


Elimination of rampamt caries due to bottle feeding.


HMO feature. II. Role of the insurance carrier.


Have dental kit, will travel. 194th Dental, New Jersey National Guard.


Use and abuse of HMO's.

Use and abuse of HMO's.


Private practice system and community dental needs.


A half-way house for dentistry.

A half-way house for dentistry.


Diagnostic x-ray procedures in dentistry.


Oral diagnosis in preventive dentistry.

Oral diagnosis in preventive dentistry.


School fluoridation.

School fluoridation.


What's your diagnosis? Fibrous dysplasia.


Mediterranean fever: dental extractions.


Fissure sealants--a review of materials available and the results of clinical trials.


A study of some relationships between educational status and dental health.


Removable appliances in the stabilisation of traumatised anterior teeth. A preliminary report.


Children's reactions to extractions under general anaesthesia.


Vestibular appliances.

Vestibular appliances.