A bacteriological study of endemic tuberculosis in birds. Typing of Mycobacterium avium strains obtained in a study of endemic tuberculosis in a Wildfowl Reserve permitted the recognition of two separate infected groups. The main infection was in Anatidae and was due to M. avium, type 1; the other was in chickens used for incubation and brooding and the predominance in it of type 2 agreed with normal experience of birds, pigs and cattle in Britain. Many of the strains isolated from the Anatidae were aberrant and methods used to investigate these are described; two of the strains may belong to a new type. Birds which died from other causes, usually trauma, often had subclinical tuberculosis and 5% of the samples of mud and soil examined yielded M. avium.


Effect of stay in hospital and oral chemotherapy on the antibiotic sensitivity of bowel coliforms. The effects of oral chemotherapy and stay in hospital on the antibiotic resistance patterns of faecal coliform flora were studied. The coliform flora of 64% of 25 patients who were not receiving antibiotics was sensitive to all drugs tested. Hospitalization alone did not affect this proportion. The administration of tetracycline or ampicillin to patients, whether at home or in hospital, significantly increased the percentage of resistant bowel coliforms. Tetracycline showed a significantly greater effect than ampicillin. There was no significant increase in the percentage of patients with resistant flora after treatment with amoxycillin.


A particle detector for use in ventilation engineering. An electronic particle counting device is described, based on a constant-temperature hot-wire anemometer probe. The device has found application in tracing the motions of droplets and measuring their concentration within ventilated areas when subjected to different types of ventilation. In this way the effectiveness of various systems may be determined.


The fate of a toxigenic strain of Staphylococcus aureus in vacuum-packaged bacon. Pork was cured by (a) the Wiltshire method and (b) a hygienic sweet cure process. Representative samples of both bacons were inoculated at ;low' density (10(3) organisms/g.) and ;high' density (10(6) organisms/g.) with a toxin-producing strain of Staphylococcus aureus, ;High' and ;low' density samples of both bacons were each stored at 5 degrees C. for 42 days and 15 degrees C. for 21 days.Results indicated that the test organism at high inoculum density grew slowly in both bacons at 5 degrees C. The organism survived at 5 degrees C. in both ;low density' bacons. At 15 degrees C. the test organism grew; growth being more pronounced in the ;hygienic' than in Wiltshire bacon.


Sonne dysentery in day schools and nurseries: an eighteen-year study in Edmonton. A study of Sonne dysentery infections in 19 primary and 11 secondary day-schools and 4 day-nurseries has been made over a period of 18 years in an urban area. Measures were taken throughout to try to prevent and control outbreaks. Sonne dysentery was not endemic in the school population and, even at times of high incidence, epidemics were localized within a few of the primary schools, usually in the spring or autumn terms. Incidence rates of Sonne dysentery were highest in primary schools with large infant departments and in nurseries. Secondary schools entirely escaped outbreaks.The co-operation of head teachers was engaged for all precautionary measures in schools. A policy of immediate exclusion of suspected and infected children was useful in preventing and controlling school epidemics of dysentery. Toilet hygiene was often poor in schools with outbreaks, and this was found to be a profitable field for applying control measures. Infected kitchen workers were only occasionally involved.Recommendations are given in the light of this study, and some reference is made to the more difficult problem posed by dysentery outbreaks in day-nurseries, where temporary closure may be the best policy. It is important that responsibility for infectious disease control in schools be clearly delineated in the reorganized health services of 1974. Teachers can play an important part in limiting infection.


Transformation of Swiss 3T3 cells by murine sarcoma virus is followed by decrease in a glycolipid glycosyltransferase.


Differences in nuclear RNA labelling patterns of Burkitt lymphoma, leukaemic lymphosarcoma and various human leukaemias.


The effect of saline on the eye irritation caused by swimming-pool water. In laboratory experiments the acute eye irritation produced by exposure to tap water was not significantly increased when chlorine compounds were added to the water at concentrations of 1 mg./l. The greatest irritation was produced by 2 mg. Cl(2)/l. as NH(2)Cl. The addition of NaCl at concentrations above about 0.5% abolished the irritant effect of tap water, and prevented irritation even when 1 mg. Cl(2)/l. was present.In a field experiment involving two swimming baths, one with fresh and the other with saline water (0.5% NaCl), eye irritation in the saline bath was significantly lower than in the freshwater bath only when the swimming time did not exceed 30 min.


Role of interferon in the anti-melanoma effects of poly (I).poly (C) and Newcastle disease virus.


RNA in nascent DNA from cultured human lymphocytes.


Research: catalyst and servant.

Research: catalyst and servant.


DNA-degradation and excision repair in gamma-irradiated Chinese hamster ovary cells.


Distribution of lactate dehydrogenase isozymes in rat liver cells.


Spectroscopic technique for studying protein rotation in membranes.


Regional distribution of 5-methyltetrahydrofolic acid in brain.


Implicit features and stereoscopy.

Implicit features and stereoscopy.


Developmental compartmentalisation of the wing disk of Drosophila.


Role of retinal image motion in evoking the McCollough effect.


Inhibition of in vitro autosensitization by a thymic humoral factor.


Importation of cholera into New Zealand 1972.


A case of cholera in New Zealand: post mortem and microbiological diagnosis.


Periodontal disease research: introductory remarks.


Isolation of Vibrio parahaemolyticus in New Zealand.


Fatal primary amoebic meningoencephalitis.


Euploidy of cultured human cervical epithelium exposed to oestradiol.


Medical education.

Medical education.


Idiopathic hypoparathyroidism following gastric surgery.


Postgraduate medical education: the graduate phase in New Zealand.


Editorial: Influenza.

Editorial: Influenza.


Editorial: Penicillin and syphilis.

Editorial: Penicillin and syphilis.


Letter: Cot deaths.

Letter: Cot deaths.


Synthetic studies on porphyrin systems.

Synthetic studies on porphyrin systems.


N-methylporphyrins.

N-methylporphyrins.


Some aspects of metalloporphyrin stereochemistry.


Interpretations of prophyrin spectra.

Interpretations of prophyrin spectra.


The magnetic circular dichroism of porphyrin dications.


The Zeeman and Stark effects in porphyrin.


Infrared spectroscopy of porphyrins.

Infrared spectroscopy of porphyrins.


Spectroscopic studies of cis and trans effects in hemes and hemins.


Nuclear magnetic resonance studies of ferric porphyrins.


Relationships between porphyrin structure and reactivity.


Mossbauer spectra of hemichromes and hemochromes derived from alpha,beta,gamma,delta-tetraarylporphins.


Synthesis and structures of novel metalloporphyrins.


Induced redox reactions of metalloporphyrins and their implications in biological systems.


Manganese porphyrin complexes. V. Axial interactions in manganese(3) porphyrins.


Kinetic studies on metal chelation by porphyrins.


Aspects of metal ion incorporation into porphyrin molecules.


The structure of free base porphine: an average of three independent structures.


Ligand-binding in porphyrin systems.

Ligand-binding in porphyrin systems.


Why chlorophyll?

Why chlorophyll?


Electrochemical studies of mmetalloporphyrins.


Photochemistry and redox activity of some metalloporphyrin complexes.


The photooxygenation of metalloporphyrins and metallochlorins.


Stereochemistry and chiroptic properties of pheophorbides and related compounds.


Cyclic voltammetry of porphyrins and metalloporphyrins.


Chemistry of water-soluble hemes.

Chemistry of water-soluble hemes.


Chlorophyll-chlorophyll interactions from 1H and 13C nuclear magnetic resonance spectroscopy.


Aggregation of properties of water-soluble porphyrins.


N-H tautomerism in porphyrins and chlorins.


Electron-impact mass spectrometry of porphyrin systems.


Variations in hydrogenation of bile pigments depending upon type of solvent and other factors.


Angular momentium, magnetic interactions, Jahn-Teller and environment effects in metalloporphyrin triplet states.


Some recent advances in tetrapyrrole chemistry.


An informal discussion on tetrapyrrole nomenclature.


Porphyrins as model systems for studying structural relationships.


Thermodynamic aspects of porphyrin synthesis and biosynthesis.


On the chromophores of porphyrin systems.


Resource-allocation models in presidential campaigning: implications for democratic representation.


Diversity of group member preferences and commitment to group decisions.


Democratic representation and apportionment: public and private good markets.


Analysis of individual preorderings to discover a typology of the individuals in a process of collective choice.


Democratic representation and apportionment: quantitative principles underlying apportionment methods.


The impact of the weighted vote on representation in municipal governing bodies of New York State.


Quantitative and descriptive guidelines to minimize gerrymandering.


Democratic representation and apportionment: a districting experiment with a clustering algorithm.


Cumulative voting: an effective electoral device for fair and minority representation.


Democratic representation and apportionment: a continous transformation useful for districting.


Democratic representation and apportionment: the Iowa redistricting system.


Democratic representation and apportionment: a redistricting algorithm applied to geographic reorganization of circuit courts.


Apportionment and legislative responsiveness to policy preferences in the American states.


The effects of reapportionment on the passage of nonexpenditure legislation.


A consumer sovereignty model of representation.


Reapportionment and policy: a further look at some intervening variables.


Legislative pluralism, committee assignments, and internal norms: the delayed impact of reapportionment in California.


Redistricting, political outcomes, and gerrymandering in the 1960s.


Empirical and normative theories of apportionment.


Influence of legislative districting on community participation in urban planning.


Democratic representation and apportionment: quantitative methods, measures, and criteria. Preface.


Local control of planning in Oyster Bay.


A theory of voter influence over foreign policy.


Pivotal states in the electoral college: an empirical investigation.


A normative theory of representative democracy.


Toward a renewal of models in political science.


Democratic representation and apportionment: committees, representation, and policy outcomes.


Genetic manipulation: now is the time to consider controls.


Letter: Condylar growth center questioned.


Letter: New image needed for oral surgery.


Editorial: The battered-child syndrome.

Editorial: The battered-child syndrome.


Correction of palatal defects: a prosthodontist's viewpoint.


Lingual anesthesia following mandibular odontectomy.


Case 4. 1.

Case 4. 1.


Odontogenic gingival epithelial hamartoma: report of case.


Benign hemangiopericytoma of the tongue.


Cannulation through vein exposure.

Cannulation through vein exposure.


The etiology of colonic cancer.

The etiology of colonic cancer.


X-ray film of the month.

X-ray film of the month.


The treatment of acute bronchial asthma in the adult.


S.C.M.A. Report of the committee on mental health of S.C. medical association 1972-73.


Treatment of acute leukemia: important role of the central nervous system. Case reports.


Studies on the mode of action of intra-amniotically and extra-amniotically injected hypertonic saline in therapeutic abortion.


Cytogenetic and clinical study on 100 cases of primary amenorrhoea.


Idiopathic myeloid metaplasia. Its evolution into acute leukemia.


Biochemical genetics of hybridisation in European house mice.


A new dominant spotting and silvering factor in the guinea-pig.


Wheezing in the child under two years.

Wheezing in the child under two years.


Thoracic outlet syndrome. Arteriographic diagnosis in pediatrics.


Anorectal manifestations of systemic disease.


Psychogenic pain.

Psychogenic pain.


The coronary care unit as a triage station for the emergency room.


The pediatric nurse practitioner in the private office.


Xeroradiography diagnosis of breast diseases.


Pulseless disease producing abdominal angina and simulating anorexia nervosa.


Precoronary care in a suburban community.


Herpes zoster and multiple myeloma.

Herpes zoster and multiple myeloma.


Nutrition in pregnancy.

Nutrition in pregnancy.


PSRO-Foundation speaks out on area designation.


The doctor's handy guide to chronic child abuse.


The development of community dentistry in dental educational curricula; activities and resources of departments.


Dental public health administration and programming.


The neighborhood health center; a case study.


Editorial: Ten facts about the American Association of Public Health Dentists.


Acute granulocytic leukemia in elderly patients.


Paediatric research in Nova Scotia.

Paediatric research in Nova Scotia.


Unilateral thymic rebound in premature infants.


Cleft lip and palate in Nova Scotia. A multidisciplinary approach to treatment.


Genetic screening by amniocentesis. The current status.


Urinary tract infections in childhood.

Urinary tract infections in childhood.


Acute appendicitis in children.

Acute appendicitis in children.


Observations on the proposed childrens' dental health plan.


Quality of medical care.

Quality of medical care.


Maritime medical care.

Maritime medical care.


Fasciitis nodularis regionis limbi et conjunctivae bulbi.


Socio-psychological factors in overeating and dieting with comments on popular reducing methods.


Vago-vagal gastro-gastric relaxation in the cat.


The physiology of contact lens imprints.


Ocular circulation in X-chromosomal maculopathy with retinoschisis.


A technique for the determination of chemical binding to soft contact lenses.


Diet and its effect on the visual system.


Keratometric reflexes on flexible lens surfaces.


Amblyopia--a case report.

Amblyopia--a case report.


Reliability of keratometer readings--addendum.


The retained tooth root.

The retained tooth root.


Dental anthropology: some variations and anomalies in human tooth form.


Fractured mandible with an unusual complication. A condensed clinical report.


An explanation for the occurrence of internal faults in porcelain jacket crowns.


The role of a calcium sucrose phosphate-calcium orthophosphate complex in the reduction of dental caries.


Schistosomiasis in Czechoslovak citizens.


Editorial: Vasoconstrictors in local anesthetic.


Faunistic-ecological investigations on blood-sucking midges (Diptera: Ceratopogonidae equals Heleidae) of the Polish coastal area.


The effect of larval density on the fertility of female Culex pipiens molestus Forsk., (Diptera, Culicidae).


Photoluminescence studies on the structure of the DNA in situ of phages Vi.


Isolation and electron-microscopic characteristics of the DNA of group Vi phages.


The presence of Vi-polysaccharide deacetylase in three morphologically different Vi-bacteriophages.


Occurrence of overweight and obesity, and their influence on the health condition of crews of the Polish Merchant Marine and Deep-Sea Fishing Companies (summary of the doctor's degree dissertation).


Hearing in persons exposed to vibration.


Lesions in the osseous-articular system of the upper extremities and cervical spine caused by mechanical vibration.


Further research on glycine content in urine in cases of oxalic urolithiasis (considering urolithiasis in seamen).


Hygienic evaluation of low-pressure marine distillation plants.


Imported malaria in Europe.

Imported malaria in Europe.


Editorial: Dental Materials and Devices programs: a public service.


PSRO: We approach the first milestone. Dental Prepayment. Council on Dental Care Programs.


A satellite is launched.

A satellite is launched.


Letter: State boards and evaluation.

Letter: State boards and evaluation.


Letter: New Zealand dental nurses.

Letter: New Zealand dental nurses.


Letter: Delivery of dental services in New Zealand and California.


Plastic deformation of the amalgam restoration as related to cavity design and alloy system.


Graphing indexes reduces plaque.

Graphing indexes reduces plaque.


An investigation of the occurrence of diastemata and supernumerary teeth.


Dental care for the hemophiliac.

Dental care for the hemophiliac.


Repair of a coronal fracture that involved the pulp of a deciduous incisor: report of case.


Joint prosthetics and speech treatment of hypernasality: report of case.


Hyperbaric oxygen treatment of mandibular osteomyelitis: report of three cases.


Mucosal cysts of the maxillary sinus: report of 75 cases.


Expenditures and prices for dental and other health care, 1935 to 1972. Bureau of Economic Research and Statistics.


Survey of recent dental graduates. IV. Cost of purchasing an established practice. Bureau of Economic Research and Statistics.


Induction, differentiation and oncogenesis.


Editorial: PSRO in your future.

Editorial: PSRO in your future.


Postnasal development of the secondary palate. A case report.


A single visit post and core procedure.

A single visit post and core procedure.


Patient training as an alternative to general anesthesia.


Dentists required to report cases of abused and maltreated children.


Adenomatoid odontogenic tumour. Periodontal aspects on diagnosis and treatment.


A clinical trial of Apernyl cones and tamponade with Ward's Wondr Pak in the treatment of dry socket.


Retinal Schiff bases: the effect of water on spectral absorption.


Selective induction of anergy to coccidioidin or tuberculin with antilymphocyte serum.


Letter: Acute myelomonocytic leukemia after cessation of androgen therapy.


Female genital self-mutilation.

Female genital self-mutilation.


Treatment of acute myeloid leukemia of adults with cytosine arabinoside in combination with 6-mercaptopurine.


67Ga scintigraphy in acute leukemia.

67Ga scintigraphy in acute leukemia.


Radionuclide studies on the growth of intrahepatic tumors and of the infiltrated liver.


Partial purification of rat urinary anorexigenic substance.


Methotrexate-induced pulmonary disease.

Methotrexate-induced pulmonary disease.


Results of transurethral resection of prostate.


N,N-dimethyltryptamine like substance in rat brain.


Disabilities of hand under social security.


Care of people with coronary arterial obstruction.


Severe liver damage caused by treatment of psoriasis with methotrexate.


Desmoid tumors of abdominal wall. Wide excision and repair with woven mesh.


Request for autopsy consent. Conflict and challenge.


Drug abuse and drugs in sports. Personal observations.


Comparison of different methods in active and passive recording of the retruded position of the mandible.


Blood flow in human temporal muscle during tooth grinding and clenching as measured by 133xenon clearance.


Neutrophil chemotactic substances in different fractions of soluble dental plaque material.


Elution of cadmium from dentures.

Elution of cadmium from dentures.


Effect of dietary iron deficiency on the pigmentation and iron content of rat incisor enamel.


Tight junctions between osteocyte processes.


Variation in root length of the permanent maxillary central incisor.


Ultrastructural alterations in ischaemic lesion of small intestinal mucosa in experimental superior mesenteric artery occlusion. Effect of oxygen breathing.


Methylated psychotogens in the urine of psychiatric patients.


Factors related to sudden death in acute ischaemic heart disease. A community study in Helsinki.


Ischaemic heart disease in women. A study based on a randomized population sample of women and women with myocardial infarction in Göteborg, Sweden.


Wear in total hip prostheses. An experimental evaluation of candidate materials.


Growth and remodelling of the ribs in normal and scoliotic pigs.


Plasma lysozyme in drug-induced and spontaneous cyclic neutropenia.


Hyperphosphatemia, hyperphosphaturia and hypocalcemia in acute lymphoblastic leukemia.


Perinatal mortality at St Helens Hospital, Auckland.


Comparative running costs of two Christchurch medical centres.


Ice therapy in soft tissue injuries.

Ice therapy in soft tissue injuries.


Repair of fractures of the orbital floor using a premoulded silastic prosthesis.


Aggravation of renal functional impairment by tetracycline.


Letter: Abbreviations.

Letter: Abbreviations.


Editorial: The role of the medical school in modern society.


Letter: An adjuvant to traditional therapy.


Oxygen uptake studies of divers when fin swimming with maximum effort at depths of 6-176 feet.


Glutathione peroxidase in human red cells in health and disease.


Depression of bone marrow delta-aminolaevulic acid synthetase activity in erythroleukaemia.


Amelogenesis imperfecta and genetic counseling.


Plaque-enamel interface in early cariogenesis.


Sialolith recorded on full-mouth dental radiographs: case report.


National Health Insurance 197?

National Health Insurance 197?


Avoiding drug interactions.

Avoiding drug interactions.


Reciprocity--to be or not to be.

Reciprocity--to be or not to be.


New legislation affecting dentistry.

New legislation affecting dentistry.


Undue radiation exposure in Third Party Dental Plans.


Systems for the delivery of dental care. Health Maintenance Organizations.


Different flow patterns and their effect on gas distribution in a lung model study.


Animal studies with topical steroids.

Animal studies with topical steroids.


Factors influencing the formulation of semisolid preparations with special reference to corticosteroid products.


Serum alkaline phosphatase activity in normal and transplantable osteosarcoma-bearing mice.


Two autopsy cases of glycogen storage disease--cirrhotic type.


Histopathological studies on thrombotic microangiopathy with special references to three cases associated with acute promyelocytic leukaemia.


Morphologic characteristics of experimentally induced lung tumors and their precursors in hamsters.


Test, tested and retested. Certification examinations in the United States.


RNA synthesis in lymphocytes after hypotonic shock.


A universal adaptor for oxygen analyzers.


Carcinoma of the colon and rectum in a defined population. An epidemiological, clinical and postmortem investigation of colorectal carcinoma and coexisting benign polyps in Malmö, Sweden.


Myotonic dystrophy and its differential diagnosis.


The dimethyltryptamine-forming enzyme in blood platelets: a study in monozygotic twins discordant for schizophrenia.


Subnormal maternal urinary oestriol excretion when the fetus has diabetes insipidus, optic atrophy, and absence of the septum pellucidum.


An aid to cervical cerclage.

An aid to cervical cerclage.


Carcinoembryonic antigen in cancer of the female reproductive system: its detection in serum by a microradioimmunoassay.


Extensive vulval condylomata acuminata necessitating caesarean section.


Rubella antibody titres, rubella vaccination, and the obstetrician.


The phospholipid test of fetal respiratory maturity: its value in clinical obstetrics.


Pregnancy complicated by accidental rubella vaccination.


The value of the amniotic fluid lecithin: sphingomyelin ratio in the management of high risk pregnancy.


Eosinophilic leukaemia.

Eosinophilic leukaemia.


Ventilatory management of the elderly.

Ventilatory management of the elderly.


Letter: Erythroleukemia with Philadelphia chromosome.


Aneurysm of the right gastric artery associated with hemorragic pseudocyst of the pancreas.


Ultrasonic measurements of left ventricular volume, mass and velocity of posterior wall movent in children (author's transl).


Stroke before 50. A follow-up study of vocational and psychological adjustment.


Incidence of HL-A antigens in acute lymphocytic leukemia.


The effect of inoculating strains of Streptococcus mutans and Streptococcus sanguis upon caries incidence and bacterial content of plaque in rats.


Side effects of rifampicin. A clinical study.


Neurohistology of human dental pulp polyps.


Circadian rhythms in the concentrations of protein and the main electrolytes in human unstimulated parotid saliva.


The effect of phytate concentration of pH and of orthophosphate on the rate of phytate adsorption by hydroxyapatite.


The effect of pH and of orthophosphate on the adsorption of phytate by hydroxyapatite during prolonged exposure.


A further study of the factors enhancing glycolysis in human saliva.


The effect of fluoride on molar socket healing in the rat.


Regulation of protein synthesis in the submandibular salivary gland of the developing rat. Ribonuclease and ribonuclease inhibitor activity.


Regulation of submandibular salivary gland protein synthesis in the developing rat. The effect of food deprivation on polysome isolation and amino acid incorporation.


Changes in nucleic acid and protein content during development of the rat submandibular gland.


Sulpholipid labelling from (35S)-sulphate by various rat tissues in vitro.


The effect of chronic frictional stimulation on hamster cheek pouch epithelium.


Further studies on the remineralization of human carious dentine in vitro.


The state of calcium and inorganic orthophosphate in human saliva.


The demonstration of a dicalcium phosphate stabilizing factor in human saliva.


Saturation of human saliva with calcium phosphates.


Influence of in vivo-incorporated fluoride on collagen metabolism by mouse calvaria in organ culture.


Fluoride levels in the surface enamel of different types of human teeth.


The standardization of electromyography of the masseter muscle in man.


Relation of chronology of deciduous tooth emergence to height, weight and head circumference in children.


Morphological changes in Streptococcus sanguis associated with growth in the presence of oxygen.


Letter: Neurotoxicity of intrathecal chemotherapy for leukaemia.


Letter: Dental auxiliaries.

Letter: Dental auxiliaries.


Peer review.

Peer review.


A selective medium for Streptococcus mutans.


Open-field concept.

Open-field concept.


How to avoid the high cost of dental work.


The Sioux Lookout dental care project: a progress report.


Sagittal osteotomy for correction of maxillo-mandibular deformities.


Premature exfoliation of the teeth with hyperkeratosis of the palms and soles: Papillon-Lefèvre syndrome.


Sedativism. A syndrome of multiple addiction.


Familial multiple polyposis. Surgery core 1972.


Clinicopathological conference of the Medical University of South Carolina. "Rheumatic-rheumatoid disease of the heart and aorta". Discussion of two cases.


Counseling couples with sexual problems.


Thyroid crisis: A case report and current treatment.


Office laboratory licensure.

Office laboratory licensure.


President's pages.

President's pages.


Unproven cancer remedies.

Unproven cancer remedies.


An operation for the correction of tricuspid atresia.


Editorial: Lay participation of physicians' workshops, yes; lay control, no.


Gamekeeper's thumb. Result of skiing injuries.


Proceedings: Problems of long-term perfusion with membrane lung.


Proceedings: Landé-Edwards membrane oxygenator for heart surgery and prolonged lung or heart support.


Electrocardiograms of the month.

Electrocardiograms of the month.


Ounces of prevention. Part II.

Ounces of prevention. Part II.


Retroperitoneal xanthogranuloma.

Retroperitoneal xanthogranuloma.


Response to crisis in emergency care. Emergency medical care committee.


Psychotherapy, encounter, and sensitivity-training groups. Present status of group practice.


Remarks of the President. The Medical Society forsees a role in the accreditation of continuing education programs.


The unaffiliated hospitals and the medical school.


Continuing education program of the Rhode Island Medical Society.


Continuing medical education in community hospitals. A new role for the librarian.


Accreditation of continuing medical education at the state level.


Editorial: Medical education.

Editorial: Medical education.


Continuing medical education through self-evaluation, community hospitals and Bi-Cycle System.


Continuing education: one specialty's approach.


Editorial: Explosive hospital costs. I. Causes.


Pathophysiology and treatment of severe asthma.


Viral hepatitis in east Harlem. Program for ambulatory treatment.


Evaluation of psychiatric hospital treatment.


Brachial-plexus palsy following brachial-plexus blockade.


Unexplained retroperitoneal air.

Unexplained retroperitoneal air.


Proximal blind-ending ureters.

Proximal blind-ending ureters.


Unusual cellular reaction to malignant melanoma in patients infused with cultured autochthonous lymphocytes.


Multicentric reticulohistiocytosis with extensive bone and joint destruction.


Prepaid group practice.

Prepaid group practice.


Sexual motivation in the female rat. A methodological study applied to the investigation of the effect of estradiol benzoate.


Oral reflexes elicited by mechanical stimulation o palatal mucosa in the cat.


Long-term effects of selective desalivation on taste acuity in rats.


Biology of the periodontium in primates of the Galago species. I. The normal periodontium in young animals. II. Inflammatory periodontal disease. III. Lability of cementum. IV. Changes changes in ageing. Ankylosis: types and sequential events.


The dental primordium, an electron microscopic study of the cervical loop.


Habituation and sensitization of the flexor reflex after asphyxiation of the spinal cord.


Coronally repositioned flap: report of four cases.


Elimination of tooth grinding habits by massed practice therapy.


Relationship of occlusion and periodontal disease. VII. Mobility.


Incidence of cervical enamel projections and its relationship to furcation involvement in Egyptian skulls.


Incidence and distribution of alveolar bony dehiscence and fenestration in dry human Egyptian jaws.


Effect of histamine-releasing agent (compound 48-80) on extraction healing in rats.


Rapid fabrication of removable orthodontic appliances.


The effect of varying the hours of light on the incidence of dental caries in rats.


Drug-induced xerostomia: cellular changes produced in parotid acinar cells by azathioprine.


Editorial: The politics of change.

Editorial: The politics of change.


Prevention of pit and fissure caries. 3. Fluoride and resin-enamel bonding.


Effects of systemic antibiotic therapy on the fine structure of gingival crevicular epithelium.


A comparison of early and late maturing 12-year-old girls.


Editorial: International relations and responsibilities--an assessment.


Finishing amalgam restorations--a scanning electron microscope study.


Sore tongue.

Sore tongue.


The ultrastructure of the connective tissue underlying the sulcular epithelium.


Dental public health on Norfolk Island.

Dental public health on Norfolk Island.


Oral manifestations of chronic lead-poisoning (plumbism): a case report.


Multifocal osteosarcoma. A case report.

Multifocal osteosarcoma. A case report.


Difference in uptake of tritiated thymidine by myelocytes from bone marrow and spleen in chronic myeloid leukaemia.


Perturbation of generation cycle of human leukaemic blast cells in vivo by daunomycin.


Clinicopathological conference: Sixty-two year old woman with chief complaint of pain in lower legs and shoulders of several years duration.


Malignant mortality in North and South Dakota: 1950-1967.


Renal trauma. West Virginia University Hospital--analysis of 48 cases (1967-1972).


Gastroscopy findings confirming diagnosis in two unusual cases. (Mallory-Weiss syndrome and Gastric polyposis).


Family politics and psychiatric hospitalization.


"ABCs'" of patient's rights.

"ABCs'" of patient's rights.


Editorial: More on abortion: a chilling subject.


Editorial: What determines the location of physicians.


Zone demarcation of organic films present on human enamel surfaces in vivo.


Postgraduate training in orthodontics.

Postgraduate training in orthodontics.


Postgraduate education in orthodontics in the United Kingdom.


Postgraduate orthodontics at the Eastman Dental Hospital.


A full-time postgraduate course in orthodontics.


Orthodontic aspects of the Joint Committee for Higher Training in Dentistry Report. A personal view.


Finishing techniques for the exit margin of the approximal portion of class II cavities.


The consultant orthodontic service.

The consultant orthodontic service.


The selection and properties of materials for dental practice. 7. Polymeric denture materials.


The selection and properties of materials for dental practice.


Some factors predisposing to injuries of permanent incisors in school children.


Multiple nodular torus palatinus of the edentulous jaw. A case report.


Isoprenaline ulceration of the tongue. A case report.


WHO, the first twenty-five years. Dental health activities.


A controlled study of a hypnotic method in the treatment of alcoholism, with evaluation by objective criteria.


Comparative jaw and tooth pathology.

Comparative jaw and tooth pathology.


Out-patient treatment of narcotic addiction. Who benefits?


Phenylthiocarbamide taste sensitivity in alcoholism.


Methadone maintenance in Auckland. The failure of a programme.


Toward a model of primary prevention of drug abuse in elementary schools.


"Conclusive evidence" and marihuana.

"Conclusive evidence" and marihuana.


Drug abuse in the East Midlands. A study of 139 patients referred to an addiction unit.


Some characteristics of an ex-addict self-help therapeutic community and its members.


An assessment of patients with periodontally involved migrated incisors.


An unusual apical abscess.

An unusual apical abscess.


An obturator of sectional design.

An obturator of sectional design.


Acute contact sensitivity to a new toothpaste.


Lateral and protrusive occlusions.

Lateral and protrusive occlusions.


In vitro comparison of solutions for topical fluoride application.


Intercellular distribution and partial purification of phosphoprotein in bovine parotid gland.


The application of microcapsules to dental materials. Experimental production of methacrylate microcapsules by use of glass-cored impalpable balls and their effect on restorative resin.


The orthopantomography--its basic images.


The mineralization pattern of developing fish tooth enameloid using X-ray probe microanalyzer, historadiography and radioactive tracer (45Ca).


Evaluation of dental procedures on hemophilic patients in a comprehansive program for the care of hemophilia. 3.


Respiratory and circulatory investigations in obstructive and restrictive lung disease.


Environment and animal health in piglet production. A field study of incidences and correlations.


The early inflammatory reaction in the fowl. A light microscopical, ultrastructural and autoradiographic study.


Equipment for inhalation anaesthesia for children.


Previous radiation exposure in patients with leukemia.


A histological study on the effect of hemolysate on rat liver.


Intracranial ossifying fibroma. Report of a case.


Health status of ocean-going oil tanker seamen.


Separation of viable from non-viable tumor cells using Ficoll-Hypaque density solution.


Primary osteogenic sarcoma of the urinary bladder.


Fusarium solani infection during treatment for acute leukemia.


Glycogen storage disease type IX: benign glycogenosis of liver and hepatic phosphorylase kinase deficiency.


Decreased ketogenesis in von Gierke's disease (type I glycogenosis).


Phosphatidylcholine exchange protein from beef liver.


Quantitative differences between N-terminal methionyl nascent globin chains of human and rabbit reticulocytes.


Biological membrane rupture and a phase transition model.


Effect of phenobarbitone on the biliary excretion of methylmercury in rats and mice.


Teratocytes as a source of juvenile hormone activity in a parasitoid-host relationship.


Stimulation of DNA synthesis in CNS neurones by sustained depolarisation.


Tetrodotoxin and cobalt blockade of neuroblastoma action potentials.


Altered neural protein in murine muscular dystrophy.


Translational control of globin synthesis by haemin in Xenopus oocytes.


Osteosarcoma of the atlas in a dog.

Osteosarcoma of the atlas in a dog.


Factors influencing survival in pediatric acute leukemia. The SWCCSG experience, 1958-1970.


System of clinical counseling for dental students.


Effects of practice-sequence strategy on cavity preparation skills.


Electromechanical simulator for aquisition of psychomotor skills in cavity preparation.


Dentist's role as team manager: developing selection and interviewing skills.


Editorial: Right on, dental students.

Editorial: Right on, dental students.


Editorial: Should there be a national licensing system for medical graduates?


Laboratory model of private practice: method for studying new systems of health care delivery in dental schools.


Pharmacologically induced behavioural supersensitivity to apomorphine.


Haemoglobin Daneshgah-Tehran alpha2 72 (EPI) histidine--arginine betaA2.


Nuclear DNA content and senescence in Physarum polycephalum.


Is avenaciolide another ionophore?

Is avenaciolide another ionophore?


The membrane abnormality of the red cell in paroxysmal nocturnal haemoglobinuria.


Enhancement of platelet and muscle actomyosin ATPase activity and superprecipitation by the tumour-promotor 12-0-tetradecanoyl-phorbol-13-acetate (PMA).


X-ray study of helix, loop and base pair stacking in trinucleoside diphosphate ApApA.


Changes in lateral geniculate neurones of rats as a result of continuous exposure to light.


Structural studies on a tyrosine tRNA precursor.


Dextran sulphate inhibits cell adhesion in tissue culture.


Chemical typing of human immunoglobulin V-kappa subgroups.


Arginine vasotocin release into cerebrospinal fluid of cats induced by melatonin.


Hereditary persistence of foetal haemoglobin associated with a gamma beta fusion variant, haemoglobin Kenya.


Configuration of bicuculline, a GABA antagonist.


Abnormal visual function in Xenopus following stroboscopic illumination.


A comparison of Berotec (Th1165a) and Salbutamol aerosols.


Low dosage haloperidol and induced anxiety in normal volunteers.


Editorial: Doctor-patient communication.


Letter: Anaesthetic safety devices.

Letter: Anaesthetic safety devices.


Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukaemia. A transient cerebral disturbance characterized by somnolence of varying degree is described in children after cranial irradiation given as part of central nervous system (C.N.S.) prophylaxis for acute lymphoblastic leukaemia in remission.Out of 28 such children receiving cranial irradiation as part of the Medical Research Council protocol for C.N.S. prophylaxis 11 (39%) developed pronounced symptoms of somnolence, anorexia, and lethargy some six weeks after the completion of cranial irradiation, and a further 11 (39%) developed these features in mild form. In all cases the symptoms were transient, no focal neurological abnormality was detected, and all children made a spontaneous and complete recovery. E.E.G. studies on five somnolent children showed similar abnormal activity of diffuse and patchy distribution over both hemispheres. Indirect evidence is presented to support the concept that this syndrome represents a transient radiation encephalopathy, analogous to acute transient radiation myelopathy, caused by temporary disturbance of myelin synthesis.


Active immunotherapy used alone for maintenance of patients with acute myeloid leukaemia. A total of 32 patients suffering from acute myeloid leukaemia were initially treated with daunorubicin and cytosine arabinoside, and eight who achieved full remission were given a brief cytoreduction course of cyclophosphamide and thioguanine. Of these eight patients seven were then actively immunized with 10 irradiated allogeneic acute myeloid leukaemia cells and B.C.G. at weekly intervals. Six of these patients have survived in apparent good health for more than one year. Bone marrow changes suggestive of relapse were used as an indication for further short courses of chemotherapy, and except on single occasions in two different patients clinical relapse has been prevented. The average duration of first (bone marrow) remission appears to be comparable with the best achieved in trials using regular chemotherapy for maintenance, though criteria for determining relapse may be different. The rate of reinduction of remissions (bone marrow) in this series was high, with a subsequent increase in overall survival time. Possible explanations for the high rate of reinduction include, firstly, the effects of active immunization with specific leukaemia antigen; secondly, non-specific adjuvant effect; thirdly, avoidance of drug resistance; and, fourthly, early diagnosis of relapse by frequent bone marrow examinations.


Letter: Norwegian scabies and monocytic leukemia.


Dermatoglyphics in children with acute leukaemia. The dermatoglyphics of 135 children with acute leukaemia differed significantly from those of normal controls, and examination of 174 of the patients' first degree relatives indicated that familial factors were involved. The findings suggested that within the racial group studied dermatoglyphics may partly identify a population subgroup which is at increased risk of leukaemogenesis. While these observations may not have immediate clinical application, they are likely to contribute to a greater understanding of individuals who have increased constitutional susceptibility to leukaemia.


Prolonged survival in osteogenic sarcoma with multiple pulmonary metastases. A case report and review of the literature.


Theoretical explanation of mouse satellite DNA renaturation kinetics.


Otological manifestations of leukemia.

Otological manifestations of leukemia.


Androgenesis in the onionfly Hylemya antiqua (Meigen) demonstrated with a chromosomal marker.


Origin and renewal of lymphocytes in avian embryo thymuses studied in interspecific combinations.


Neural dopaminergic vasodilator control in the kidney.


Increased cytokinin from root system of Perilla frutescens and flower and fruit development.


A study of the treatment of epistaxis.

A study of the treatment of epistaxis.


The effect of aromatic amines on the blood.


Identification of tRNA precursor molecules made by phage T4.


Isolation of feather keratin mRNA and its translation in a rabbit reticulocyte cell-free system.


Improved estimation of secondary structure in ribonucleic acids.


Control of cell proliferation and cytodifferentiation by a factor reacting with the cell surface.


Dopamine and 5-hydroxytryptamine inhibit feeding in rats.


Darkness-induced reduction of the number of synaptic ribbons in fish retina.


FSH stimulation of testicular androgen binding protein.


Two populations of L-glutamate receptors on locust muscle fibres.


Attitudes of adolescent cigarette smokers.


Why the patients came.

Why the patients came.


Retroperitoneal fibrosis.

Retroperitoneal fibrosis.


A review of blood culture isolates at Green Lane Hospital 1967-1972.


Burns from enuresis alarm apparatus: case report.


Editorial: Drug-induced blood dyscrasias.


Letter: Pancreatic secretion after vagotomy.


Letter: Vibramycin.

Letter: Vibramycin.


Human leukemic cells. Effect of human growth hormone.


Editorial: Cytogenetics and cancer.

Editorial: Cytogenetics and cancer.


Compelling splenectomy in medically compromised patients.


Optimum time and temperature for stress relief heat treatment of stainless steel wire.


Experimental production of lingual carcinomas in hamsters: tumor characteristics and site of formation.


Phosphoenolpyruvate-dependent glucose transport in oral streptococci.


Alloantibodies induced in histoincompatible rats by single pulp and tooth grafts.


Acid treatment of cavities under resin fillings: bacterial growth in dentinal tubules and pulpal reactions.


Effect of temperature on rheological properties of four dental restorative materials.


Reaction of dicalcium phosphate dihydrate with fluoride.


Effects of acid etchants on dentin.

Effects of acid etchants on dentin.


Radiographic determination of the length of maxillary and mandibular incisors in rats.


Analyses of components of periodontal disease.


Simple nanogram method for the estimation of fluoride in mineralized specimens.


Influence of the adrenal glands on the sialic acid content of submaxillary and retrolingual glands in the rat.


Linear growth study of the pharyngeal cavity.


Reaction of acidulated phosphate-fluoride solutions with human apatite.


Enamel microsampling technique for assessing fluoride uptake from topical fluoride treatments in vitro.


A study of the dental student-patient relationship.


Enzyme-histochemical determination of human bone growth activity in postmortem material.


Bacterial degradation of streptococcal glucans.


Characteristics of an induced variant of Bacterionema matruchotii.


Mitral reconstruction with commissural cusp of fascia lata.


Editorial: Explosive hospital costs. II. Solutions.


Amphetamines, valuable adjunct in treatment of Parkinsonism.


Dermatologic evaluation of pruritus in patients on hemodialysis.


Pitfalls in surgical drainage of acute lung abscesses.


Effects of fluorides in the in vitro plaque model system from human salivary sediment.


Frictional behavior and surface failure of human enamel.


Assessment of sutural and cranial growth in young guinea pig skulls: a quantitative tetracycline labeling study.


Efficacy of sample combustion techniques for tritium recovery after tritiated cortisol injections in pregnant A-Jax mice.


Catamenial pneumothorax, observations and speculations.


Tracheal regeneration in long-term survivors with silicone prosthesis.


Cervicomediastinal thymic cyst.

Cervicomediastinal thymic cyst.


Apparatus for applying compressive forces to cells in vitro.


Correlation conferences in radiology and pathology. Calcified right upper quadrant mass containing air.


Clinical anesthesia conference. Severe hypotension following administration of propranolol hydrochloride.


Wellbeing of the pregnant.

Wellbeing of the pregnant.


The psychological care of patients with terminal illness.


Gastrocolic fistula complicating benign gastric ulcer.


Phytate inhibition of enamel hardening by mineralizing solutions.


Effect of fluoride ions and actinobolin on apatite growth at enamel surfaces.


[Opening of NZSNA conference at Hamilton, July 3, 1973].


A method of recording and scoring erosion in hamsters.


Visualization of the human mental nerve through intact oral mucosa.


Psychiatric concepts.

Psychiatric concepts.


Admissions to psychiatric hospitals.

Admissions to psychiatric hospitals.


How do nurses feel about alcoholism?

How do nurses feel about alcoholism?


Community health action.

Community health action.


The psychological care of patients with terminal illness. II.


A visit to Australian hospitals.

A visit to Australian hospitals.


We uncovered treasure. An experiment in ward management at Cook Hospital, Gisborne.


Study leave in UK.

Study leave in UK.


Proceedings: Surgical treatment of initial priapism and recurrent priapism.


Respiratory assistance for neonates and infants.


Biological effects of repeated leukapheresis of patients with chronic myelogenous leukemia.


Effects of GABA, imidazoleacetic acid, and related substances on conductance of crayfish abdominal stretch receptor.


Diagnosis of busulfan lung by transcatheter biopsy.


Diameters of collagen fibrils grown in vitro.


Poly(A) sequences in plant polysomal RNA.


Amplification, polytenisation, and nucleolus organisers.


Factors that influence the appearance of central nervous system leukemia.


Synergistic effects of oesterogen and progesterone on ovomucoid and conalbumin mRNA synthesis in chick oviduct.


Selectivity isotherms for permeation of monovalent cations in gallbladder epithelium.


A new method for separation of human blood components.


Causes of female offending.

Causes of female offending.


Acute leukaemia of adults in Auckland: changing duration of survival.


Prescriptions in general practice.

Prescriptions in general practice.


Azathioprine administration to NZB X NZW hybrid mice with lupus nephritis: beneficial effect complicated by development of malignant lymphomas.


Flexion injuries of the pancreas.

Flexion injuries of the pancreas.


Editorial: Health centres.

Editorial: Health centres.


Letter: Acupuncture.

Letter: Acupuncture.


New Zealand Committee on Adverse Drug Reactions. Eighth annual report.


Vitamin E deficiency in human liver disease and its relation to haemolysis.


Studies on the proliferative capacity of the in vitro colony forming cell in normal human bone marrow.


Clinical features of nonfunctioning chromophobe adenomas.


Risk of infection with scalp vein needles--a prospective study.


Digoxin concentrations in the serum and myocardium of digitalised patients.


A comparison of the cardiovascular effects of proscillaridin and ouabain in anaesthetised dogs.


Alteration of urate metabolism by weight reduction.


The treatment of progressive supranuclear palsy with L-dopa.


Tuberculosis and blood disorders.

Tuberculosis and blood disorders.


Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 66-Paris).


Maxillary ostectomies for preprosthetic surgery.


Experience with the use of intravenous diazepam in outpatient procedures.


Case 4, Part 2, squamous cell carcinoma of the hard palate.


Pansinusitis, orbital cellulitis, and blindness as sequelae of delayed treatment of dental abscess.


Basal cell nevus syndrome: 20-year follow-up.


Oral surgical management of a patient with malignant pheochromocytoma.


Cherubism: report of case.

Cherubism: report of case.


Editorial: What's in a name?

Editorial: What's in a name?


Fact or fancy--a reasoned view of halothane.


Ion diffusion in lecithin-water lamellar phases.


Extensive transformation of lymphocytes by a mycoplasma organism.


Serum binding of Ca2+ and cystic fibrosis.


Partial fertility of artificial hybrids between Asiatic and American cockleburs (Xanthium strumarium L.).


Evidence for common genetic determinants of nitrogenase and nitrate reductase in Rhizobium meliloti.


New findings on cephalosporin C biosynthesis.


pK of thiamine C(2)H.

pK of thiamine C(2)H.


An evaluation of the success of dental care in the United Kingdom.


Cleft microform. A case report.

Cleft microform. A case report.


Bite marks in perishable substances. A method of producing accurate permanent models.


Submandibular sialolithiasis in a child. A case report.


Radiography and radiology for the dental practitioner. 9. Radiation protection.


Fluoride in the prevention of dental caries. A tentative cost-benefit analysis. 5. The cost-effectiveness of professionally-administered topical applications of fluoride solutions.


The surface finish of composite restorative materials.


Oral medicine for the dental practitioner. 3. White patches of the oral mucosa.


Idiopathic internal resorption. An unusual clinical presentation.


Problems of older people: forced idleness, impoverishment, ill health, isolation. Opening statement.


Patterns of health and illness in older people.


Integrated psychiatric services for the aged.


Scandinavian experiences in health and social services for older people.


Learning to die.

Learning to die.


Coronary artery disease in the aged.

Coronary artery disease in the aged.


In praise of old people: in outrage at their loneliness.


Social isolation and isolation-reducing programs.


The crisis of work for older people.

The crisis of work for older people.


Problems of older people: forced idleness, impoverishment, ill health, isolation. A concluding response.


Alveolar bone loss in periodontal disease and the metacarpal index.


Determination of sulfur volatiles in putrefied saliva by a gas chromatography-microcoulometric titrating system.


Development of the deep lamellar corneoscleral resection technique.


Mo Kwong mobile refraction service.

Mo Kwong mobile refraction service.


Further observations in the use of retinal gelfilm in scleral buckling procedures.


Primary chronic angle-closure glaucoma in a young woman of 19 years--case repot.


Current status of the keratoprosthesis.

Current status of the keratoprosthesis.


Squint surgery with tenoplication or buckling as a surgical procedure.


The possibility of artificial tissue or organ for the eye.


Microsurgery of lacrimal sac.

Microsurgery of lacrimal sac.


Some aspects of Australia aboriginal eye disease.


The Maori eye.

The Maori eye.


New observation on retinal microcirculation at the posterior pole in man.


The macula following surgical reattachment of the retina.


Optic nerve decompression in benign intracranial hypertension.


An appraisal of iridocyclectomy.

An appraisal of iridocyclectomy.


Pupillary membrane microsurgery.

Pupillary membrane microsurgery.


The clinical significance of optic nerve hypoplasia.


Eskimos and eye disease.

Eskimos and eye disease.


Epidemic conjunctivitis in Singapore in 1970 and 1971.


Theoretical ophthalmology.

Theoretical ophthalmology.


Presidential address: Asia-Pacific Academy of Ophthalmology.


Keratomycosis with emphasis on the diagnostic and therapeutic value of anterior keratectomy.


Mycotic infections of cornea.

Mycotic infections of cornea.


Statistics of blindness in Thailand.

Statistics of blindness in Thailand.


Ocular conditions among the Orang Asli, the jungle aborigines of West Malaysia.


Retinal haemorrhages in newborns after delivery with the vacuum-extractor.


Photocoagulation of macular disease.

Photocoagulation of macular disease.


Cataract cryosurgery (analysis of 1,500 consecutive cases).


Types of diabetic retinopathy and treatment. Diabetic retinopathy is currently the most frequent cause of newly-occurring blindness.  4 different classifications of diabetic retinopathy, varying with the seriousness of symptoms, are listed.  For each type, the following information is discussed:  1) characteristic feature; 2) opthalmoscopic appearance and history; 3) clinical signs; 4) biochemical investigation; and 5) recommended treatment.  Microscopic photographs illustrate the discussion.  Etiological factors of each type are mentioned briefly.  The aim of all therapy is to convert the abnormal parameters observed in the 3 seroius types of retinopathy into those found in the minimal category.  Current commonly practiced treatment--pituitary ablation and light coagulation of the retina--are drastic and not always successful.


The combined use of fluorescein angiography and colour infra red photography.


Fundus oculi findings associated with cardio-pulmonary bypass procedures.


Glaucomatous cupping of the optic disc in the young.


Primary angle closure glaucoma: geographic and racial variations.


The incidence and racial distribution of pterygium in West Malaysia.


Iris inclusion for chronic glaucoma.

Iris inclusion for chronic glaucoma.


Results in 350 cases of surgical decompression of the optic nerve.


Effect of glaumarin upon glaucoma.

Effect of glaumarin upon glaucoma.


Cryo extraction of senile cataracts: a modified approach.


Electronic digital computer control of ventilation and anaesthesia.


The harmonized dental team performance.

The harmonized dental team performance.


Problems of partial removable dentures with unilateral free-end-saddle.


An efficient tooth preparation technique.


The engine-driven canal preparation.

The engine-driven canal preparation.


The A.T.R. endodontic method. The iodine silver nitrate root canal treatment in one appointment.


A traction attachment for unerupted teeth.


Functional occlusion--the final test of orthodontic success.


Timing of facial growth: a study of relations with stature and ossification in the hand around puberty.


Regional variations in the provision of orthodontic treatment in England and Wales.


The indication for distal movements of upper buccal segments.


The place of fixed bridgework in cleft palate patients.


Useful clinical technique for upper canine retraction and retention.


High tensile wires in removable appliances.


The problem of overbite in Class II, division 2 malocclusion.


The changing pattern of European orthodontics.


Orthodontic treatment needs in English children aged 11-12 years.


Evaluating your accountant.

Evaluating your accountant.


Simplified bleaching of non-vital teeth.


The ideal patient.

The ideal patient.


A day in the life of an orthodontic assistant.


The fallacy of centric related casts.

The fallacy of centric related casts.


Diagnosis and case presentation--the chicken or the egg?


Editorial: How do we meet the needs of today's DA?


10 questions, and Loyola Dental Dean Suriano's answers.


Anterior rubber dam application.

Anterior rubber dam application.


Radiation characteristics and controls. I.


A dentist's wife talks about the money trap.


My fees are not usual and customary.

My fees are not usual and customary.


Corporate practice...which way to retirement? 5.


Credit card billing is a boon to my practice.


Dental stocks: diamonds in your own back yard.


What prevention has done for my practice.


Steps to a successful retirement.

Steps to a successful retirement.


What do your patients really think of you?


Lo, the vanishing tax shelters.

Lo, the vanishing tax shelters.


Distant early warning system for your practice.


Wondering what patients think? Why not ask them.


Who needs ethics?

Who needs ethics?


Neuromuscular control of mandibular movement.


Developing occlusion in the mixed-dentition period.


The relationship of occlusion to restorative dentistry.


Unionization comes to the classroom.

Unionization comes to the classroom.


Bid adieu to dead beats?

Bid adieu to dead beats?


Planning the dental office: establish priorities, with the doctor's needs first.


Graphics spell "fun"--by design.

Graphics spell "fun"--by design.


Occasional pain, soreness of cheek.

Occasional pain, soreness of cheek.


Editorial: When periodontal deformities aren't preventable.


Color it bright to gain "space".

Color it bright to gain "space".


Dentist confirms that it pays to follow planning principles.


How computerized billing can conserve staff time, energy.


Efficient patterns pay bonus in freedom.


When it's better to remodel than to build.


The swing-lock partial removable denture.


Replantations. Case reports.

Replantations. Case reports.


Greene V. Black, Dentist.

Greene V. Black, Dentist.


Osteitis deformans. Case report.

Osteitis deformans. Case report.


Editorial: The dentist a specialist in the service of general health.


Utilization of the clinical conference.

Utilization of the clinical conference.


The value of bite mark evidence.

The value of bite mark evidence.


Dental nomenclature.

Dental nomenclature.


Editorial: Forensic dentistry.

Editorial: Forensic dentistry.


Observations on teeth roots in the estimation of age.


Sex identification of a human tooth.

Sex identification of a human tooth.


The identification of the teeth.

The identification of the teeth.


Experimental studies on bite marks.

Experimental studies on bite marks.


Significant problems of the forensic odontologist in the U.S.A.


The use of iodine-125 x-ray unit at the site of the aeroplane disaster in Dubai.


The extraction--nonextraction decision.

The extraction--nonextraction decision.


A practical comparison of the three basic types of crown and bridge cements.


Inventory control.

Inventory control.


Face bow plier.

Face bow plier.


Simplified model trimming.

Simplified model trimming.


Going through another phase or the prostitution of dentistry.


Occlusal considerations in orthodontics.


The Orthopedic uni-splint.

The Orthopedic uni-splint.


Ethics and dental care.

Ethics and dental care.


Editorial: The quality of general dentistry is not strained...?


Archwire length measuring device.

Archwire length measuring device.


Politics and dentistry need not be strange bedfellows.


Correction of severely rotated teeth.

Correction of severely rotated teeth.


Journal interview: Carlton Williams.

Journal interview: Carlton Williams.


Jco interviews Dr. Brainerd F. Swain.

Jco interviews Dr. Brainerd F. Swain.


Sale of an orthodontic practice. Part I.


Attitudes of South Carolina dentists toward composite resins: results of a survey.


Editorial: The "apathy until it hits the fan syndrome".


What is your diagnosis? Squamous cell carcinoma of the maxillary sinus.


Some atypical orthodontic cases.

Some atypical orthodontic cases.


Cyanoacrylate in the cementation of threated retentive pins.


Clinical use of some dental materials. I: Amalgam.


A report on the feasibility of a plague control program with the use of dental floss at a second grade level in a school setting.


Dental student evaluation of the dental school environment.


The case for a substantial increase in Indiana's state cigarette tax rate.


Prepayment and review. Points to ponder.


The Michigan dentist and his continuing education. I. Background characteristics and 1st findings.


A representative of Trustee District 9 evaluate the ADA.


The cons of licensure.

The cons of licensure.


Position paper of the ADA on licensure regulation.


Licensure in Texas.

Licensure in Texas.


The pros of licensure.

The pros of licensure.


American dentistry in a Japanese prison, days of infamy recalled.


Topical treatment of prepared cavities.

Topical treatment of prepared cavities.


Letter: Oxymetholone and hematologic disease.


Failure of N,N-dimethyltryptamine to evoke tolerance in cats.


Editorial: The crisis in dental health care: real or imagined.


The self assessment and continuing education program. Some comments by participants.


Prevention--fact, fad or myth?

Prevention--fact, fad or myth?


Prevention: a way of life.

Prevention: a way of life.


Prevention revisited: a view from academe.


Preventive dentistry--fact or fad?

Preventive dentistry--fact or fad?


Keeping up with significant issues in the literature.


Some observations on dental education.

Some observations on dental education.


Positive 99mTc-polyphosphate scan in case of metastatic osteogenic sarcoma and hypertrophic pulmonary osteoarthropathy.


Condylar movement patterns engraved in plastic blocks.


Influence of cavity design, heat treatment, and cementation on MOD gold inlays. I. Proximal permanent deformation under occlusal stress.


Observations on a composite resin for Class II restorations: three-year report.


What we really see in a TMJ radiograph.

What we really see in a TMJ radiograph.


Forensic odontology.

Forensic odontology.


Delay in admission to a coronary-care unit.


Clinical and diagnostic features of Reiter's disease: a follow-up study of 39 patients.


Factors effecting the drop-out of trainee nurses at Oakley Hospital.


Hereditary methaemoglobinaemia due to enzyme deficiency: a case report and study of a Chatham Island family.


Editorial: Hearing aids.

Editorial: Hearing aids.


Editorial: Marihuana.

Editorial: Marihuana.


Letter: Diet and coronary artery disease.


Biologic effects of dental materials. 4. Effect of polycarboxylate cements on Hela cells in vitro.


Endodontic recall procedures. A survey of endodontic diplomates.


Panoramic innominate line and related roentgen anatomy of the facial bones.


Hidden cyst.

Hidden cyst.


Double dens invaginatus.

Double dens invaginatus.


Degradation rates of polymers and copolymers of polylactic and polyglycolic acids.


Modulation of cortical inputs from tooth pulp by electrical stimulation of adjacent gingiva.


The incidence of bacteremia following oral prophylaxis on pediatric patients.


Chondroma of the tongue.

Chondroma of the tongue.


Amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis.


Malignant primary intraosseous carcinoma of the mandible.


Advanced education programs in endodontology.


Clinical trichuriasis produced experimentally in growing pigs. I. Pathology of infection.


Clinical trichuriasis produced experimentally in growing pigs. II. Anthelmintic efficacy of dichlorvos.


Assay and pharmacokinetics of clonazepam in humans.


Experiences with Bivotril in treatment of epilepsy--particularly minor motor epilepsy--in mentally retarded children.


The rate of dosage increase of clonazepam.


Effect of clonazepam (Ro 5-4023) on interictal EEG abnormalities.


A clinical trial with clonazepam (Ro 5-4023).


Clonazepam in the treatment of epilepsy.


Dosimetry at interfaces. Theoretical analysis and measurements by means of thermoluminescent LiF at plane interfaces between a low Z-material and Al, Cu, Sn or Pb irradiated with 100 to 200 kV roentgen radiation.


Museum radiography with dental x-rays.

Museum radiography with dental x-rays.


Persistent diabetes and ketoacidosis due to L-asparaginase therapy.


Editorial: United we stand divided we fall.


1973 Report from the Board of Governors. Task force faces CDA internal problems.


Quebec position on membership in the CDA.


Voluntary conjoint membership.

Voluntary conjoint membership.


Traumatic (haemorrhagic) bone cyst of the mandible: report of an unusual case.


Editorial: Social trends and dental practice.


Letter: The new Dental Service Corporation.


Letter: The New York Dental Service Corporation.


Effects of dentifrices on soft tissues of the oral cavity.


The N.Y. Dental Service Corp.--present status. A report.


A procedure for finsihing composite restorations.


Rebasing the complete maxillary denture.


Stafne defect of the anterior mandible.

Stafne defect of the anterior mandible.


Clinical immunology with reference to the oral cavity.


Intravenous sedation in general dentistry. A rational use of pentobarbital, meperidine and scopolamine.


Pulpal necrosis following orthodontic therapy. Report of two cases.


Factitial disease of the gingiva and buccal mucosa. Report of a case.


Correlation of diagnostic methods used in Sjögren's syndrome.


The teaching hospital--who needs it?

The teaching hospital--who needs it?


Evolution of the surgicenter.

Evolution of the surgicenter.


The diagnosis of common neck masses.

The diagnosis of common neck masses.


AMA activities concerning Professional Standards Review Organization: progress report.


Editorial: PSRO and the hospitals.

Editorial: PSRO and the hospitals.


Villous adenomas. A rare but remediable cause of life threatening electrolyte imbalance.


Diagnostic patterns in disability. South Dakota and the nation.


A medical school for South Dakota.

A medical school for South Dakota.


Cementum repair after apicoectomy in humans.


The fine structure of the vessels in the human dental pulp.


A computerized method for quantitative estimation of the epithelium-connective tissue interface applied to the gingiva of various age groups.


Enzymatic reduction of the colonization of Streptococcus mutans in human dental plaque.


Bite force in children with bruxism.

Bite force in children with bruxism.


The problem of the distal extension partial denture.


Surgical correction of inflammatory papillary hyperplasia of the palate.


Histiocytosis X of the mandible. Case report.


Chapter 1. Experience with lumbar disc surgery.


Aging changes in the periodontium.

Aging changes in the periodontium.


Use of silver points in root canal obturation.


Abrasion resistance of restorative materials.


A lipoma in the buccal vestibule. Report of a case.


The use of electrosurgery in oral implantology.


Myopathy associated with type 3 glycogenosis.


Systems and methods in dental practice.

Systems and methods in dental practice.


Editorial. Electronic electrosurgery's role in present day dentistry.


A difficult endodontic treatment. Case report.


Clinical and therapeutic aspects of impacted teeth. Transplantation of impacted canines.


How do I motivate my patients toward good and permanent oral hygiene?


The complete coverage restoration and the gingival sulcus.


Registration technique in daily practice.


Modifications of the Andresen-Haüpl activator. IV.


Environment and the origin of cancer.

Environment and the origin of cancer.


Clinical and therapeutic aspects of impacted teeth. Operative removal of retained mandibular third molars (type I).


Exposure and alignment of misplaced cuspids.


Modifications of the Andresen-Haüpl activator (V).


What is a cancer cell?

What is a cancer cell?


The influence of mental development on children's acceptance of dental treatment.


A follow-up study of post- or pinretained amalgam fillings with special reference to possible corrosion.


Histomorphologic investigations on the effect of cyclophosphamide on dentinogenesis of the rat incisor.


Autoradiographic investigations on the effect of cyclophosphamide on dentinogenesis of the rat incisor.


Activity and distribution of acid phosphatase in zinc-deficient parakeratotic rat buccal epithelium.


Our candidate for president-elect of the American Dental Association.


Tooth supported complete dentures: twenty-seventh year of observation.


Adjustment of occlusion.

Adjustment of occlusion.


What price prevention? A case report.

What price prevention? A case report.


Extension of duties of auxiliary personnel.


Maxillary and mandibular osteotomy for maxillary and mandibular protrusion.


Venereal disease and dentistry.

Venereal disease and dentistry.


Credit for dental patients.

Credit for dental patients.


How about your entrance hall, doctor?

How about your entrance hall, doctor?


Would your patients recommend you?

Would your patients recommend you?


Scanning electron microscope studies of the chemotherapeutic control of preclinical cariogenic infection.


Modulation of the excitatory synaptic response by fast transient K+ current in snail neurones.


Sleep studies and therepeutic trial with L-dopa in a case of Stiffman syndrome.


Isolation and transcription of 3' terminal regions of unique DNA molecules.


Evidence for control of several different tissue-specific isozymes of adenosine deaminase by a single genetic locus.


Suggested mechanism for increase in size of the genome.


Synthesis of plant virus coat proteins in an animal cell-free system.


Membrane antigens in arginine-deprived cultues infected with Marek's disease herpesvirus.


Allotopic properties of human brain monoamine oxidase.


Acetylcholine noise in tissue culture muscle cells.


Release of calcium induced by 'depolarisation' of the sarcoplasmic reticulum membrane.


Effect of strychnine on dorsal root potentials and amino acid responses in frog spinal cord.


Polyriboinosinic-polyribocytidylic acid prevents chemically-induced malignant transformation in vitro.


Criterion for active fluid secretion in vivo.


Transient DNA satellite in dedifferentiating pith tissue.


Comments and further observations on the structure of eserine (physostigmine).


Experimental observations on prophylactic and therapeutic vaccination against foot-rot in sheep.


The acute toxicity of four common poisons to the opossum, Trichosurus vulpecula.


The potential role of pasture management in the control of trichostrongyle worm infection in calves with observations on the diagnostic value of plasma pepsinogen determinations.


Letter: The possible relationship of selenium and superphosphate to the frequency of intestinal carcinomas in sheep.


Potentiated trimethoprim for the therapy of calf scours.


The identity and prevalence of coccidia species in sheep and cattle in New Zealand.


The field detection of "inter-unit milk flow" in pipeline milking equipment.


Suspected copper deficiency in a group of full sib Samoyed dogs.


A case of multiple xanthomatosis and diabetes mellitus in a dog.


Multiple forms of elongation factor 1 from calf brain. Heavy and light forms of elongation factor 1 (EF-1) from calf brain have been partially purified. The heterogeneous heavy species (EF-1(H)) with molecular weights of 2.5 x 10(5) to over 1 x 10(6) appears to be a complex or aggregate of the light form of the enzyme (EF-1(L)); the latter has a molecular weight of between 50,000 and 60,000. EF-1(H) but not EF-1(L), contains significant amounts of free and esterified cholesterol. Although EF-1(H) and EF-1(L) are both active in aminoacyl-tRNA binding to ribosomes, EF-1(L) reacts with GTP and aminoacyl-tRNA more efficiently than EF-1(H).


Dependence of the proton magnetic resonance spectra on the oxidation state of flavodoxin from Clostridium MP and from Peptostreptococcus elsdenii. The broadening of protein nuclear magnetic resonances in the spectra of the semiquinone forms of flavodoxins derived from Clostridium MP and Peptostreptococcus elsdenii relative to the resonances in the oxidized and reduced forms is highly selective. Spectra from both species of flavodoxin indicate that conformational differences between the oxidized and fully reduced states are minor and, consequently, the broadening in the semiquinone form is ascribed to the paramagnetic effect of the flavin free radical. The chemical shifts of the paramagnetically broadened lines are used in conjunction with x-ray crystallographic models to assign peaks to amino-acid residues in the proximity of the flavin mononucleotide. Species-dependent differences in the spectra can generally be attributed to differences in amino-acid composition and sequence. The spectra from both species of flavodoxin indicate that there is slow exchange between oxidized and semiquinone forms or reduced and semiquinone forms of the flavodoxins with a limit of k(ex) < 50 sec(-1) for the exchange rate.


Three-dimensional structure of the Fab' fragment of a human immunoglobulin at 2,8-A resolution. The structure of the Fab' fragment of a human myeloma immunoglobulin was determined by x-ray crystallographic analysis at 2.8-A resolution. The Fourier map of the electron density was correlated with the aminoacid sequence to obtain a three-dimensional model. Four globular subunits, which correspond to the homology regions of the light and heavy chains, are arranged in a tetrahedral configuration. These subunits closely resemble each other, sharing a basic pattern of polypeptide chain folding. In each subunit, long sequences of tightly packed, hydrogen bonded polypeptide chain run parallel to the major axis of the subunit. No helical conformation can be seen. Different patterns of interchain disulfide linkage and unusual intrachain disulfide bonds that have been observed in other immunoglobulins can be explained with this model. The regions of hypervariable sequences in the light and heavy chains occur at one end of the molecule, in close spatial proximity.


"Private" genetic variants and the frequency of mutation among South American Indians. Electrophoretic studies were performed on 15 proteins of blood serum and of erythrocytes, from blood specimens from 72 villages of six relatively unacculturated and genetically pure Indian tribes of South America, for a total of 56,237 determinations. At least 10 different "private" variants were encountered, in 131 people. Two previously recognized genetic polymorphisms of these 15 proteins were also encountered. On the assumption that these variants are neutral from the standpoint of natural selection, and that only one-third of amino-acid substitutions in proteins result in electrophoretically detectable variants, the mutation rate is estimated from a formulation of Kimura and Ohta to be about 8 x 10(-5) per locus per generation. The calculation involves several approximations which can be improved by further investigations; if confirmed, then for this class of mutations Indian mutation rates are roughly an order of magnitude higher than commonly envisioned.


Analysis of gene diversity in subdivided populations. A method is presented by which the gene diversity (heterozygosity) of a subdivided population can be analyzed into its components, i.e., the gene diversities within and between subpopulations. This method is applicable to any population without regard to the number of alleles per locus, the pattern of evolutionary forces such as mutation, selection, and migration, and the reproductive method of the organism used. Measures of the absolute and relative magnitudes of gene differentiation among subpopulations are also proposed.


Both the fast and slow refolding reactions of ribonuclease A yield native enzyme. The fast reaction ((T2) approximately 50 msec) observed previously in the refolding of thermally unfolded ribonuclease A (disulfide bonds intact) has now been studied by two properties indicative of enzyme function: binding of a competitive inhibitor (2'CMP) and hydrolysis of a substrate (CpA --> C > p + A). Both the binding and catalytic reactions are fast (<2 msec) compared to refolding. Binding of 2'CMP occurs during both fast and slow refolding reactions, and the protein folded in the fast reaction has a normal binding constant for 2'CMP. Recovery of enzymatic activity during the fast refolding reaction, as measured by the rate of CpA hydrolysis, parallels the kinetic curve for 2'CMP binding. When the kinetics of refolding are measured by the burying of exposed tyrosine groups, no difference is found. The presence of 2'CMP has no effect on the kinetics of refolding. The results show that the fast refolding reaction does not yield an intermediate in the refolding of RNase A. Instead, both fast and slow refolding reactions have a common product, fully active RNase A. Although they show a 100-fold difference in rates of refolding, the starting materials for the fast and slow refolding reactions have similar properties, as regards: (a) the molar absorbancy at 286 nm, reflecting the state of exposed tyrosine groups, and (b) their apparent failure to bind 2'CMP.


Mutations affecting N-acetylglucosaminidase in Dictyostelium discoideum. A procedure for screening several thousand clones for alterations in a specific gene product was apapplied to mutagenized cultures of Dictyostelium discoideum. Six strains were recovered which had less N-acetylglucosaminidase (EC 3.2.1.30) than the wild type. In addition, we isolated four strains in which the enzyme was temperature-sensitive. The enzyme from one of these strains had an altered substrate affinity.N-Acetylglucosaminidase is present at a low level in cells grown on bacteria and increases up to 10-fold during the aggregation stage of development. The enzyme appears to be essential to maintain migrating pseudoplasmodia of normal size, as shown by the fact that all of the mutant strains which accumulate very little N-acetyl-glucosaminidase formed only small migrating pseudoplasmodia containing less than 10% the number of cells found in the wild-type pseudoplasmodia. The small pseudoplasmodia migrated at less than a third the rate of wild-type pseudoplasmodia and ultimately formed diminutive fruiting bodies. N-Acetylglucosaminidase thus appears to be a developmental enzyme that functions during the migration stage.


The mode of action of vitamin K. Isolation of a peptide containing the vitamin K-dependent portion of prothrombin. Previous evidence has indicated that vitamin K functions in a metabolic step that specifically alters a precursor protein and converts it to biologically active prothrombin. This alteration appears to be related to the biosynthesis or attachment of a noncarbohydrate prosthetic group [Nelsestuen and Suttie (1972) J. Biol. Chem. 247, 8176]. We report the isolation of a peptide from bovine prothrombin that contains the vitamin K-dependent region of the molecule. The properties of the isolated peptide would appear to account for the major differences observed between prothrombin and its biologically inactive form produced by animals administered Dicumarol orally. These differences are quantitative absorption onto insoluble barium salts and the ability to bind calcium ions. The observed properties of this peptide provide direct evidence for the presence of a covalently bound noncarbohydrate prosthetic group(s) on the prothrombin molecule.


Intrasomatic injection of radioactive precursors for studying transmitter synthesis in identified neurons of Aplysia californica. We introduced radioactive precursors directly into identified neurons of Aplysia californica. [(3)H]-Choline and L-[(3)H]tryptophan were injected with pressure into nerve cell bodies to study synthesis of acetylcholine and serotonin. We confirmed the cholinergic nature of R2, L10, and L11, identified neurons of the abdominal ganglion. Cells in the LD cluster (which contains motor neurons to the heart and gill) also converted most of the injected choline into acetylcholine. Neurons in the RB cluster (which contains an excitatory motor neuron to the heart) and the two metacerebral cells of the cerebral ganglion converted injected tryptophan to serotonin. No cell studied could convert both choline to acetylcholine and tryptophan to serotonin. Pressure permits rapid injection of precursors, from small amounts to amounts large enough to saturate intracellular synthetic pathways. In contrast to the results with injection, we found far less synthesis of acetylcholine and serotonin in identified nerve cell bodies when ganglia were incubated in the presence of the radioactive precursors.


Microsurgically fused human somatic cell hybrids: analysis and cloning. Cell fusion by microsurgery permits production of specified bicellular hybrid cells with very high efficiency. Systematic analysis of the fate of bicellular hybrids reveals fundamental properties of cells in accordance with cell type. Bicellular hybrids that do not proliferate survive 1-21 days; those that do proliferate form clones 8-9 days after fusion.


Formation of lipid-bound oligosaccharides containing mannose. Their role in glycoprotein synthesis. Incubation of GDP-[(14)C]mannose with liver microsomes and magnesium ions led to the formation of dolichol monophosphate mannose and of other acidlabile compounds that contain oligosaccharides. Formation of these compounds was enhanced by addition of an acceptor lipid in the same fractions of DEAE-cellulose chromatography where bound dolichol is found. Alkaline treatment of the oligosaccharides, obtained by acid methanolysis, followed by paper electrophoresis, gave rise to the formation of two positively charged substances believed to be formed by deacetylation of hexosamine residues. Incubation of the oligosaccharide-containing compounds with liver microsomes and manganese ions resulted in a transfer to endogenous protein. The role of dolichol derivatives in glycoprotein synthesis is discussed.


Nonheuristic computer determination of molecular structure based upon carbon-13 nuclear magnetic resonance data: branched alkanes. A computer-based system for elucidation of molecular structure is described for the branched alkanes, based upon (13)C nuclear magnetic resonance data. All possible structures of a given carbon content are exhaustively generated in a DENDRAL-like manner, and scored according to the fit of their predicted spectral characteristics to those of the "unknown" alkane. The technique may be generalized to any class of organic compounds for which (13)C chemical-shift additivity parameters are reliable, and shows promise for stereochemical elucidation.


Regulation of hemoglobin beta-chain synthesis in bone marrow erythroid cells by alpha chains. Synthesis of alpha and beta chains of hemoglobin was studied in vitro in intact reticulocytes and bone marrow cells. The cells were from rabbits having a variant form of hemoglobin in which L-isoleucine is in the alpha but not in the beta chains. This characteristic permitted a selective inhibition of alpha-chain synthesis to be produced by addition to the incubation medium of L-O-methylthreonine, an inhibitor of protein synthesis that is a specific antagonist of L-isoleucine. In studies with reticulocytes, 25 mM L-O-methylthreonine produced a 60-70% inhibition of alpha-chain synthesis, but beta-chain synthesis was unaffected even after incubation times for 4 hr. Because reticulocytes contain a pool of uncombined alpha chains which might have obscured the demonstration of an alpha chain-dependent mechanism for beta-chain synthesis, subsequent studies were done with bone marrow cells. The latter had little or no detectable alpha-chain pool. A substantial inhibition of alpha-chain synthesis by the bone marrow cells was produced by the isoleucine antagonist but was also accompanied by a significantly decreased rate of beta-chain synthesis. These findings suggest that the coordinated synthesis of the complementary alpha- and beta-globin chains of hemoglobin may reflect in part a modifying effect of alpha-chain synthesis on the synthesis of beta chains.


Lipid bilayer phase transition: density measurements and theory. The overall change of density for dipalmitoyl lecithin bilayers agrees with a general order-disorder theory and yields about seven gauche rotations per molecule for the biologically relevant high-temperature phase. The shape of the curve of density against temperature is similar to the result of an exact calculation on a specific model, which gives a 3/2-order phase transition.


Attempt to immunize guinea pigs against leukemia by skin scarification with leukemic cell suspensions. An attempt was made to immunize "strain 2" guinea pigs by superficial skin scarification with small doses of L2C leukemic cell suspensions. Among 203 scarified guinea pigs, 32 developed progressively growing leukemic tumors at the site of skin scarification. In 35 guinea pigs small intradermal tumors that appeared at the site of scarification regressed spontaneously; however, 15 guinea pigs in which the intradermal tumor regressed later developed generalized leukemia. In addition, 13 other animals developed generalized leukemia, without an apparent local tumor formation at the site of scarification. A total of 60 out of 203 scarified guinea pigs (30%) died from leukemia.143 Guinea pigs that survived the scarification were challenged by subcutaneous inoculation of massive doses (0.5 ml each of a 10-fold dilution from a 10% extract) of leukemic cell extracts and only 48 (34%) developed leukemia; 95 guinea pigs (66%) resisted the challenge and remained in good health. In a control experiment, 156 untreated "strain 2" guinea pigs were inoculated subcutaneously (0.5 ml each) with L2C leukemic cell suspensions of 10(-2) or 10(-3) dilution, and all but two (99%) developed generalized leukemia.


Reticulocyte RNA-dependent RNA polymerase. A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely inactive as a template. With poly(A,G) as a template, only UTP and CTP are incorporated into polynucleotide chains, indicating that the RNA polymerase is an RNA replicase and not a terminal transferase. With messenger RNA as a template, all four ribonucleoside triphosphates are required for maximal activity. The RNA-dependent RNA polymerase reaction is extremely sensitive to low concentrations of heme, rifamycin AF/013, and ribonuclease and resistant to actinomycin D and DNase. The discovery of RNA-directed RNA synthesis in reticulocytes offers an additional site for control of gene expression in mammalian cells and provides a possible mechanism for amplification of the expression of specific genes.


Circular dichrosim of chromaffin granule proteins in situ: analysis of turbidity effects and protein conformation. The circular dichroism spectra for proteins in situ in catecholamine secretory vesicles (chromaffin granules) is presented together with an analysis of protein conformation and turbidity effects on the spectra. The calculational analysis has resolved scattering and absorption effects in the turbid suspension spectra using a coated-sphere scattering model which allows for different materials in its shell and core. The intrinsic conformation of the proteins in situ was estimated by an iterative procedure with various trial protein conformations, for the chromaffin granules both intact and after release of their contents. The resulting average secondary structures (within about 10%) are: (25% alpha helix, 15% beta structure) for the membrane proteins and (15% alpha helix, 5% beta structure) for the soluble contents. The protein conformation did not change with osmotic release of the granule's contents. Consequently, if chromogranins are involved in a catecholamine storage complex, this is not reflected in any detectable change in their average secondary structure.


Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. In immature animals, ablation of the entorhinal cortex elicited a rapid intensification of acetylcholinesterase (EC 3.1.1.7) staining in the outer one-quarter of the molecular layer of the dentate gyrus. Subsequent lesions of the septum eliminated this acetylcholinesterase intensification. Electron-microscopic histochemical analysis demonstrated a 30-fold increase in the number of acetylcholinesterase-positive synaptic endings in the intensification zone. The acetylcholinesterase augmentation thus appears attributable, in part at least, to an increase in the number of acetylcholinesterase-rich synaptic endings established by septo-hippocampal fibers. Observations in a comparative study of immature and adult rats point to the animal's developmental state as a major determinant of differences in these lesion-induced neuronal adjustments.


Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon. Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule characteristics, as well as the relative hormone levels, suggest that the early population of differentiated endocrine cells is in fact composed of glucagon-producing (A) cells. This high level of glucagon is present in the embryo much earlier than the metabolic processes thought to be controlled by this hormone. Moreover, glucagon-producing cells may be the first endocrine cells to differentiate. Other known endocrine products accumulate later, during the terminal stages of organogenesis. These observations suggest that glucagon may have a regulatory function in early embryogenesis.


Nonrepetitive DNA sequence representation in sea urchin embryo messenger RNA. Messenger RNA was prepared from developing sea urchin gastrulae by puromycin release from polyribosomes. Approximately 60% of the total mRNA radioactivity of the postnuclear supernatant was recovered and shown to be free of any other labeled RNA species such as ribosomal and nuclear RNA. The mRNA was examined by hybridization to DNA present in great excess. The mRNA hybridizes almost exclusively with nonrepetitive DNA. Almost all of the messenger RNA molecules of sea urchin gastrulae therefore consist of transcripts from nonrepetitive sequences. It appears that the structural genes expressed at this stage are typically not repeated in the genome and the mRNA does not include recognizable repetitive sequence.


In vitro binding of retinol to rat-tissue components. The high-speed supernatant fraction of rat liver, lung, kidney, testis, and intestinal mucosa contains a component capable of binding [(3)H]retinol in vitro when binding is analyzed by sucrose density gradient centrifugation or gel filtration. This binding component can be distinguished from one identified in rat serum. Whereas the tissue component sediments in the 2S region of sucrose gradients, the serum component sediments in the 4.6S region. Molecular weight estimations by gel filtration indicate molecular weights of 16,000 and 67,000 for the tissue and serum binding components, respectively. Unlabeled retinol, but not retinoic acid, competes for the binding of [(3)H]retinol in tissue cytosols. Competition for the binding of [(3)H]retinol by unlabeled retinal has also been observed in tissue cytosols, but may result from the in vitro reduction of retinal to retinol. Unlabeled retinol, retinal, and retinoic acid fail to compete for the binding of [(3)H]retinol in serum under the conditions used. The tissue binding component (testis) is sensitive to digestion with Pronase, but not with RNase or DNase, indicating a protein nature for this component.


Identification of a disulfide-linked procollagen as the biosynthetic precursor of chick-bone collagen. Chick cranial-bone procollagen, extracted at neutral pH in the presence of inhibitors of proteolytic enzymes, exists as a triple-stranded protein with disulfide bonds linking all three chains. The biosynthetic precursor function of this procollagen was demonstrated by pulsechase experiments. The ratio of radioactive hydroxyproline to proline in proalpha chains obtained by reduction and alkylation of the disulfide-bonded precursor was similar to the value determined for proalpha1 from acid-extracted procollagen. However, the molecular weight of these chains was higher than that previously determined for proalpha1 and proalpha2, suggesting that extraction of tissue at low pH results in a selective loss of disulfide-bonded regions from procollagen. These findings reconcile several apparently conflicting reports on the nature of procollagen identified in bone and in the medium of cultured fibroblasts and indicate that in both systems procollagen is synthesized as a disulfidelinked protein.


Relatedness of mouse satellite deoxyribonucleic acid to deoxyribonucleic acid of various Mus species. Mouse (Mus musculus musculus) satellite DNA is able to reassociate with repeated DNA sequences of Mus caroli and Mus cervicolor, but low thermal stability of the products indicates significant differences between satellite and related DNAs of these two Mus species. There appear to be several satellite-related populations in M. caroli DNA, each of which forms hybrids of low thermal stability with repeated sequences of M. cervicolor DNA. DNAs from the subspecies Mus musculus molossinus and Mus musculus castaneus reassociate with mouse satellite to form hybrids of very high thermal stability, but the satellite content of M. m. musculus DNA is only about 60% that of M. m. musculus DNA. Reassociation of M. m. musculus nonrepeated DNA with M. m. molossinus DNA reveals no detectable differences between them; reassociation with M. caroli (or M. cervicolor) DNA yields a product whose melting temperature depression relative to homologous DNA is about 5 degrees .


Conformational control of the interaction of eukaryotic elongation factors EF-1 and EF-2 with ribosomes. As in the case with prokaryotic systems, Artemia salina elongation factors EF-1 and EF-2 interact with a common site or with closely overlapping sites on the Artemia ribosome. This feature of ribosomal design must restrict interaction with the ribosome to only one of the factors at alternating steps of chain elongation. In support of this view we find that EF-1, but not EF-2, interacts with the post-translocation ribosome, whereas the reverse is true of the pre-translocation ribosome. Conformational changes probably account for the alternating selectivity of the translating ribosome for each elongation factor.


Global models of growth and competition. Very precise data on the dynamics of a competitive system of two species of Drosophila have been obtained. By a curvilinear regression approach, analytical models of competition have been fitted. By statistical and biological criteria of simplicity, reality, generality, and accuracy, the best of these models has been chosen. This model represents an extension of the Lotka-Volterra model of competition; it adds a fourth parameter that controls the degree of nonlinearity in intraspecific growth regulation. It represents a similar extension of the logistic model of population growth.


The interaction of elongation factor G with N-acetylphenylalanyl transfer RNA-ribosome complexes. N-Acetyl-Phe-tRNA, nonenzymically bound to the acceptor site of Escherichia coli ribosomes, readily undergoes translocation in the presence of elongation factor (EF)-G and GTP. The translocated N-acetyl-Phe-tRNA, bound to the ribosomal donor site, prevents further interaction of EF-G with the ribosome, for it inhibits the GTP hydrolysis that takes place in the presence of EF-G and ribosomes and it decreases the formation of either the GDP.EF-G.fusidic acid.ribosome complex or the 5'-guanylylmethylenediphosphonate.EF-G.ribosome complex. Deacylation with puromycin of the donor site-bound N-acetyl-Phe-tRNA reverses these inhibitions, even though the tRNA(Phe) moiety remains bound to the ribosme. These results suggest that ribosomes complexed with messenger RNA and peptidyl-tRNA may be restricted in their ability to interact with EF-G to that part of the elongation cycle when peptidyl-tRNA is in the acceptor site, and deacylated tRNA in the donor site. Deacylation of the donor site-bound peptidyl-tRNA associated with peptide bond formation may control the interaction of EF-G with the ribosome.