Glucose arteriovenous differences across muscle in McArdle's disease.


Tracheostomy obstruction secondary to a T-adapter.


Development, etiology and diagnosis of increased tooth mobility and of traumatic occlusion.


A method for quantitative measurements of toothmobility.


A leukemic adolescent's verbalization about dying.


Incomplete crown-root fracture in pulpal-periodontal disease.


Recovery of some acrylic dental resins after repeated loading. 1. Laboratory study.


Some aspects on the analysis of pulpal vasculature using perfusion with Mixobar and photogrammetric evaluation. An experimental study in dogs.


Recovery of some acrylic resins after repeated loading. 2. Clinical study.


Aspiration biopsy of head and neck tumours.


An electromyographic study of the function of the lateral pterygoid muscle.


Bifid canal in a mandibular first pre-molar. A case report.


A statistical test for measuring unimodal clustering: a description of the test and of its application to cases of acute leukemia in metropolitan Atlanta, Georgia.


Program of Oneida-Herkimer County Dental Society.


A clinical evaluation of the ability of denture cleaning solutions to remove dental plaque from prosthetic devices.


Origin of the Philadelphia chromosome. Tracing of chromosome 22 to parents of patients with chronic myelocytic leukemia.


Anemia, epigastric pain and anorexia in an 18-year-old male.


Pharmacology of anticoagulants.

Pharmacology of anticoagulants.


Sweet indiscretion.

Sweet indiscretion.


Unilateral proptosis with loss of vision.


Serious side effects from routine doses of non-Mao inhibitor antidepressants. How "well" is well tolerated?


Skin complications of heroin addiction. Bullous impetigo.


Thrush of urinary bladder due to Candida guilliermondii.


Carcinoma of duodenum.

Carcinoma of duodenum.


Patterns of referral from family practice.


Mini-clinic outreach program. Hospital house calls.


"Home" for aged.

"Home" for aged.


Depression, failure, and guilt.

Depression, failure, and guilt.


Ludwig's angina.

Ludwig's angina.


Hemifacial hypertrophy. Report of two cases.


Macroscopic satellite cyst formation in the odontogenic keratocyst.


Case reports of evaginated odontomes in Caucasians.


Hermansky-Pudlak syndrome (HPS): a proposed block in glutathione peroxidase.


Fibrinolytic activity in dental cysts.

Fibrinolytic activity in dental cysts.


Radiographic examination of the edentulous patient. II. Differences in number and location of root fragments.


The origin of localized increased radiopacity in the dentin.


Bilateral supernumerary incisors.

Bilateral supernumerary incisors.


Root section in the submaxillary space.

Root section in the submaxillary space.


Impaction of deciduous mandibular incisor.


A quantitative analysis of triple fluorochrome labeling in the coronoid process of lathyritic rats.


On folic acid metabolism in human normal leukocytes of peripheral blood.


Isolation of a cytopathic agent from the plasma of a leukemic cow.


The action of alcohol in the brain.

The action of alcohol in the brain.


A further insight into the metabolism of certain  -carbolines.


Regional distribution of brain 5-hydroxytryptamine in rat strains selected for their alcohol intake.


The role of cerebral serotonin in the ethanol preference of animals.


A biogenic amine hypothesis for alcohol tolerance.


Facilitation and inhibition of learning and memory by alcohol.


Short-term memory and the alcoholic blackout.


Alcoholism and the central nervous system.


Alcoholism. II. Withdrawal, neurological syndromes, and EEG.


Alcoholism. 5. The withdrawal state.

Alcoholism. 5. The withdrawal state.


Quantitative study of alcohol withdrawal signs in mice.


Alcohol, barbiturate, and bromide withdrawal syndromes in mice.


The role of hypomagnesemia and respiratory alkalosis in the genesis of alcohol-withdrawal symptoms.


The value of electroencephalography in alcoholism.


Thoughts on the pathophysiology of Wernicke's disease.


Experiments aimed at separating the mechanical circulatory effects of ethanol from specific chemical effects. An introduction to a biophysical analysis of a toxic state.


Protein and ribonucleic acid metabolism in brains of mice following chronic alcohol consumption.


Demyelination in the central nervous system in chronic alcoholism: central pontine myelinolysis and Marchiafava-Bignami's disease.


Neuron specificity and ethanol: where does alcohol act in the brain.


Ethanol-induced sleep in relation to serotonin turnover and conversion to 5-hydroxyindoleacetaldehyde, 5-hydroxytryptophol, and 5-hyroxyindoleacetic acid.


Alcohol dehydrogenase in brain: a toxicologic role?


Alcoholism and the central nervous system. Morphinelike alkaloids.


Alcohol, aldehydes, and biogenic amines.


Adrenocortical activation in alcoholics during chronic drinking.


Tetrahydroisoquinoline alkaloids from condensation of alcohol metabolites with norepinephrine: preparative synthesis and potential analysis in nervous tissue by gas chromatography.


Biogenesis of biologically active alkaloids from amines by alcohol and acetaldehyde.


Autopsy study of leukemia in atomic bomb survivors, Hiroshima-Nagasaki, 1949-1969.


Radiation damage to the periphery and center of human osteogenic sarcoma. Histologic and tissue culture studies.


Hypersplenism in a child with acute lymphatic leukemia.


Installation problems in dental practice.


Thought patterns in choosing and using dental equipment and devices.


Hodgkin's disease article congratulated.


Transplantation of third molar.

Transplantation of third molar.


Masticatory ability--cineradiographic observations.


Studies on polycarboxylates and related cements. I. Analysis of cement liquids.


An unusual cause of increased tooth mobility during orthodontic treatment. A report of 2 cases.


Alveolar bone resorption in two edentulous populations.


Studies on polycarboxylates and related cements. 2. Analysis of cement powders.


An unusual complication while using a Fergusson's mouth gag. A clinical case.


Fibre-optics.

Fibre-optics.


the relationship between transverse strength and testing methods for dental ceramics.


Further studies on radio-opaque denture-base materials.


Recertification--to be or not to be.

Recertification--to be or not to be.


Calculation of stress distribution in keratoconus.


Diagnostic problems in traumatic diaphragmatic hernia.


Management of breast masses.

Management of breast masses.


Traumatic rupture of tracheobronchial tree.


Iatrogenic causes of pneumothorax. Increasing incidence with advances in medical care.


Idiopathic hypertrophic subaortic stenosis in patients with coronary artery disease. Importance of recognition and principles of management.


Tracheal bifurcation prosthesis.

Tracheal bifurcation prosthesis.


Triggerpoints.

Triggerpoints.


Massive atelectasis incident to anesthesia.


Alcoholism with noncirrhotic ascites. Pancreatic ascites.


Emergency thyroidectomy.

Emergency thyroidectomy.


Peer review. Philosophic second look.

Peer review. Philosophic second look.


Osteomyelitis of frontal bone secondary to mucormycosis.


Psychiatric training of graduate nursing students. Use of small interactional groups.


Alcohol-induced disabilities.

Alcohol-induced disabilities.


Plaque and periodontics.

Plaque and periodontics.


The TMJ disfunction syndrome.

The TMJ disfunction syndrome.


Testing commercially available topical fluoride agents in the laboratory.


Applied anatomy in toothbrushing.

Applied anatomy in toothbrushing.


Patient referral.

Patient referral.


Total dental health for the total population. "Today's dream--tomorrow's reality".


The value of instant pictures.

The value of instant pictures.


The four phases of human teething.

The four phases of human teething.


Behavior modification in dentistry.

Behavior modification in dentistry.


Bone-marrow lymphocytes in acute lymphoid leukaemia: effect of therapeutic regimes.


Evaluation of pain of dento-alveolar origin.


Patients at risk.

Patients at risk.


Emergencies and complications from sedation modalities.


Faints and spells.

Faints and spells.


Evaluation of patients with maxillofacial pain.


Complications of local anesthesia.

Complications of local anesthesia.


Cardiopulmonary crises in the dental office.


Trauma to permanent anterior teeth and alveolar processes.


Surgical misadventures.

Surgical misadventures.


Management of fractured root fragments.

Management of fractured root fragments.


Resume of present medical--legal standards.


Locating centric relation with a leaf gauge.


A modified lower anterior porcelain-veneer crown preparation.


Jaw movements in young adult men during chewing.


Kit construction of a silver electroplater.


Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.


Leukemia after chemotherapy of Hodgkin's disease.


Descending spinal motor tract regeneration after spinal cord transection.


Dentistry of tomorrow: the changing dental scene.


Pauline Korenblit: Russian dentist's wife speaks out.


Tel-Aviv University retrains Russian dentists.


A patient requiring a full-mouth crown and bridgework reconstruction.


Unusual spread of dental infections.

Unusual spread of dental infections.


Panoramic radiography in general practice.


An approach to periodontal therapy.

An approach to periodontal therapy.


Composite filling materials--a few thoughts.


Dental training on the West Coast of the U.S.A.


Public policy toward environment 1973: a review and appraisal. Food plants.


Public policy toward environment 1973: a review and appraisal. Forests and timber processing.


Public policy toward environment 1973: a review and appraisal. Land animals.


Public policy toward environment 1973: a review and appraisal. Special regions.


Public policy toward environment 1973: a review and appraisal. Static and mobile construction.


Public policy toward environment 1973: a review and appraisal. The space program.


Public policy toward environment 1973: a review and appraisal. Population, health, and family.


Public policy toward environment 1973: a review and appraisal. Human genetics.


Public policy toward environment 1973: a review and appraisal. Education.


Diphenhydramine hydrochloride; its use as a local anesthetic in dentistry.


Public policy toward environment 1973: a review and appraisal. Identification and development of human potential.


An evaluation of the analgesic activity of meperidine and fentanyl.


Public policy toward environment 1973: a review and appraisal. Environmental information.


Public policy toward environment 1973: a review and appraisal. Review of reviews.


Placebo pharmacology.

Placebo pharmacology.


Public policy toward environment 1973: a review and appraisal. Noise.


Public policy toward environment 1973: a review and appraisal. Climate and weather control.


Public policy toward environment 1973: a review and appraisal. Water.


Public policy toward environment 1973: a review and appraisal. Earthquakes.


Public policy toward environment 1973: a review and appraisal. Fossil energy.


Public policy toward environment 1973: a review and appraisal. Nuclear and other energy.


Public policy toward environment 1971: a review and appraisal. Introduction.


Public policy toward environment 1973: a review and appraisal. Minerals and metals.


Public policy toward environment 1973: a review and appraisal. Marine life.


Treatment of the temperomandibular joint dysfunction syndrome.


The veneered tooth.

The veneered tooth.


The value of toothbrushing in the pre-school child.


Why sedation?

Why sedation?


Pre-clinical training.

Pre-clinical training.


Anxiety in dentistry.

Anxiety in dentistry.


Management of the avulsed tooth.

Management of the avulsed tooth.


Precautions when handling mercury in dental surgeries.


The mandibular complete over denture.

The mandibular complete over denture.


Orthodontic considerations for the general practitioner.


The importance of a good medical history.


Scar tissue--a factor in complete denture service. A case report.


Acupuncture.

Acupuncture.


Life insurance--how much is enough?

Life insurance--how much is enough?


Socialism and Christ.

Socialism and Christ.


The people in a d.a.'s life ...

The people in a d.a.'s life ...


Men, women, and patients. My strangest case.


The dental firing line. The "feeling tone".


Good taxes + good sense=good investing.

Good taxes + good sense=good investing.


Fluoride in Arizona.

Fluoride in Arizona.


Should you have a Swiss account?

Should you have a Swiss account?


The d.a. How interesting is your office?


Dr. Kenneth Fox D.D.S. Sierra sculptor.

Dr. Kenneth Fox D.D.S. Sierra sculptor.


Physiological orthodontic extrusion of fractured incisors.


Educational, occupational, and marital status of cleft palate adults.


Observations on the dentition and face in clefts of the alveolar process.


The modified striped Y--a systematic classification for cleft lip and palate.


Quanti-scaling of articulatory defectiveness in cleft palate speakers.


A proposed modification for the classification of cleft lip and cleft palate.


Cephalometric evaluation of facial growth in operated and non-operated individuals with isolated clefts of the palate.


Translocation of unerupted permanent bicuspid bud.


Listening preference and discrimination for cries of non-cleft palate children, repaired cleft palate children, and non-repaired cleft palate children.


Vocal compensation: an ultrasonic study of vocal fold vibration in normal and nasal vowels.


The sphincteric mechanism of velopharyngeal closure.


The exposure of medical and dental students to the disorder of cleft palate.


Vitamin C test.

Vitamin C test.


The dental assistants role in implantology.


CDA assists in oral surgery performed under acupuncture anesthesia.


The task before us. II.

The task before us. II.


Suction tip placement and manipulation.

Suction tip placement and manipulation.


Your investments.

Your investments.


The money sickness ... have you got it?

The money sickness ... have you got it?


Facing a tax audit ... why me, oh Lord? Why me?


"I quit", she said.

"I quit", she said.


Learning to live with peer review. 2.

Learning to live with peer review. 2.


Your telephone--hotline to hiring.

Your telephone--hotline to hiring.


Dr. Nelson's magnificient Monday mornings.


The doctor who talked too much.

The doctor who talked too much.


Phasing out price controls: where the profits are.


Variable life insurance: new hedge against inflation.


Does money make you sick?

Does money make you sick?


Divorce dental style.

Divorce dental style.


So you want to build a building: financing.


All the things you are.

All the things you are.


The closed end funds: looking better than before.


That boo-boo on your tax return: what happens if it's caught?


Big new weapon for your small tax problems.


So you want to build an office building.


How the tax shelters stand up now: agriculture.


Licensure: by whom?

Licensure: by whom?


Split your income; cut your taxes.

Split your income; cut your taxes.


History of maxillofacial prosthesis.

History of maxillofacial prosthesis.


Future directions in dental education.

Future directions in dental education.


Dentistry approaches the age of region.

Dentistry approaches the age of region.


National licensure and reciprocity.

National licensure and reciprocity.


"I'm for keeping state board exams".

"I'm for keeping state board exams".


Changing dental schools into dental schools.


How the three-year curriculum affects the dental student.


Hospital dentistry: part of dental education?


Ohio's governor demands dental-education payback.


Why preventive dentistry is a must.

Why preventive dentistry is a must.


You've got a friend.

You've got a friend.


Tips on selecting a dental laboratory.

Tips on selecting a dental laboratory.


Practicing dentistry in the community health center.


The effects of burnishing margins of silver amalgam restorations.


A male hygienist?

A male hygienist?


Wives learn what their husbands are up to.


Is that any way to treat a patient?

Is that any way to treat a patient?


The dental student is a doctor.

The dental student is a doctor.


Pit and fissure sealants.

Pit and fissure sealants.


"Keep the faith"--on upholding the responsibilities of an alumnus to dental education.


Graduation plus one.

Graduation plus one.


As it looks from here.

As it looks from here.


Getting it off the ground.

Getting it off the ground.


Making your first office last.

Making your first office last.


What to do until the patients come: ethical public relations for dentists.


Congratulations, you're the proud new employer of ...


Patient considerations in a dental practice.


Your non-dental assistant.

Your non-dental assistant.


People-dontics.

People-dontics.


Fundamental operative techniques for young practitioners of dentistry.


Will you be on somebody's list?

Will you be on somebody's list?


Should you consider gold foil for your patients?


Watch your fees and dues.

Watch your fees and dues.


Education and ethics.

Education and ethics.


Lift up thine eyes.

Lift up thine eyes.


To be or not to be ... a union member.

To be or not to be ... a union member.


Community commitments.

Community commitments.


CNBDE: friend or foe?

CNBDE: friend or foe?


Clinics, caries and couples.

Clinics, caries and couples.


Correct placement of restorative finish lines.


Masticatory function studies by cineradiographic investigation of the placement of the food bolus.


Tumor scintigraphy with radiogallium and radiostrontium.


Diagnostic potentialities of scintillation scanning of the salivary glands using Tc99m -pertechnetate.


On the use of vacuum film adapters to reduce x-ray exposure during panorama enlargement roentgenograms.


The radiological management of blow out fractures.


Measuring elements on intraoral radiographic films.


X-ray diagnosis of ameloblastoma.

X-ray diagnosis of ameloblastoma.


On the radiological diagnosis of giant cell tumors.


Selective arteriography of the maxillary artery.


The myth of permanent dentistry.

The myth of permanent dentistry.


Managua--five seconds to tragedy.

Managua--five seconds to tragedy.


A new era of dentistry for Florida.

A new era of dentistry for Florida.


Understanding and diagnosing oral disease.


Sterilization of ventilators.

Sterilization of ventilators.


The Orthoscan camera.

The Orthoscan camera.


Ligature cutter-director.

Ligature cutter-director.


Universal torquing auxiliary.

Universal torquing auxiliary.


Practice management for orthodontists. 4.


Filling root canals with gutta percha.

Filling root canals with gutta percha.


Diagnosis please.

Diagnosis please.


Standard for dentrifice.

Standard for dentrifice.


Leukemia--the dental aspects. A case report.


Motivation and preventive dentistry.

Motivation and preventive dentistry.


Achieving understanding through ARC.

Achieving understanding through ARC.


The wear of hard dental tissue ...a review of the literature.


A study on the size of permanent teeth, shovel shaped incisors and paramolar tubercle in Thai skulls.


Ameloblastoma developing from a dentigerous cyst.


Dentistry's role in developing dental health manpower data and strategies at the state and local level.


Current concepts in education and accreditation standards.


Law and economics of dental practice.

Law and economics of dental practice.


The relationship between socio-economic factors and preventive dentistry in fourth graders.


Painless dental education through puberty.


The dentist and oral cancer.

The dentist and oral cancer.


Educational aspects of pain control.

Educational aspects of pain control.


Rationale for regulation.

Rationale for regulation.


Regulation--no solution.

Regulation--no solution.


The gold inlay and plaque control.

The gold inlay and plaque control.


A frightening dental program.

A frightening dental program.


Clinical utilization of Restodent. Case report.


Cementifying fibroma of maxilla. Case report.


An insight into New Jersey.

An insight into New Jersey.


The use of Nuva-Seal in operative dentistry.


Presence of accessory pulp canals.

Presence of accessory pulp canals.


Paget's disease. Case report.

Paget's disease. Case report.


The future of group practice.

The future of group practice.


Iatrogenic factors in periodontal disease.


Utilization of dental services in Rhode Island.


Effects of tetracycline on the respiratory activity of odontoblasts of rat incisors.


Health maintenance organizations.

Health maintenance organizations.


Socio-odontologic investigation of school children with high and low caries frequency. V. Socio-economic factors and dental condition in the parents.


Oral cancer in rats induced by the water-soluble carcinogen 4-nitrochinoline N-oxide.


The Cleveland system for dental health education.


Histopathological changes in rat incisors in experimental carbon tetrachloride intoxication.


Ohio Dental Association activities--Peer review--Ohio Department of Public Welfare.


The health care delivery system in Canada.


Black participation.

Black participation.


Dental insurance in Ontario. 2.

Dental insurance in Ontario. 2.


What's in the future for dental education.


Management firms and taxes.

Management firms and taxes.


Peer review.

Peer review.


Fissure sealant technics.

Fissure sealant technics.


Case history--use of blade implant.

Case history--use of blade implant.


The treatment of apical periodontitis. Apicoectomy with retrograde root canal filling.


Current status and future prospects for plastic filing materials. 3.


Foreign body in the maxillary sinus.

Foreign body in the maxillary sinus.


Substitution of a mesiodens for a lost tooth.


Modern solutions of prosthodontic problems.


The dental team concept. II. A report evaluated by the FDI Commission on Dental Practice and its working group on chairside ergonomics.


Reconstruction of the floor of the mouth and vestibule of an edentulous mandible.


Care and treatment of large cysts according to Partsch II, with autohemotherapy (Schulte).


How to motivate patients toward effective and permanent oral health.


Ceplak disclosing tablets--an aid for oral hygiene.


Patient motivation in periodontal prosthesis.


Removable onlay veneer dentures.

Removable onlay veneer dentures.


The x-ray examination of dentogenous diseases of the maxillary sinus.


Minimal assistance, extensive assistance, complete chairside assistance. A guideline for the arrangement of the working area.


Current position on the usefullness of cyanoacrylates in dentistry.


Osteolytic jaw defect in a case of plasmacytoma.


Concerning the extraction of fractured teeth.


Endodontic implants.

Endodontic implants.


A simplified method for the precision placement of composite resins and cements.


Retaining the vitality of an injured tooth.


The surgical removal of unerupted teeth--a method for the prevention of crowding.


Pulpotomy.

Pulpotomy.


Economical construction of bite planes for symptomatic treatment of temporomandibular joint dysfunction.


The Fédération Dentaire Internationale and its significance for dental practice administration. I.


Dental and oral hygiene habits of students at the University of Erlangen-Nuremberg.


Endodontic implants. 2.

Endodontic implants. 2.


Significance of the Christensen phenomenon in complete denture construction.


Histological pulp changes after preparation for a jacket crown. Action of an inpregnating solution on the pulp of teeth ground for jacket crowns.


A case of compromise.

A case of compromise.


A technique for constructing full dentures using the Gerber articulator and condyloform teeth. 2.


A conservative approach for prosthetic intervention.


Studies of proximal abrasion.

Studies of proximal abrasion.


The alginate impression.

The alginate impression.


Endodontic implants. 3.

Endodontic implants. 3.


A new wedge.

A new wedge.


How do I motivate my patients towards good and permanent oral hygiene?


Experiences using the Lege Artis thermal test for vitality testing.


Simplified construction of stable custom clutches for pantographic tracing. 1.


Oral rehabilitation--restoration of an extensively edentulous mouth while respecting the patient's wish that a minimal amount of gold be visible.


Applications of Dentape in the dental practice and in the laboratory.


Improved results with Scutan by mixing on a vibrator.


Modification of the Andresen-Haupl activator. 1.


There's nothing new under the sun--electrosurgery.


Simplification of radiographic technique.


The Fédération Dentaire Internationale and its significance to dental practice administration. 3.


The importance of a medical history.

The importance of a medical history.


Dental health education and the school dental nurse.


Clinical evaluation of two toothbrushes.


The bladevent implant.

The bladevent implant.


A "brush in" with the self administered stannous fluoride treatment paste.


Powdered gold restorations.

Powdered gold restorations.


Bleaching fluoride stained teeth.

Bleaching fluoride stained teeth.


Replantation of an evulsed tooth.

Replantation of an evulsed tooth.


About your staff.

About your staff.


The venous system--occupational hazard?

The venous system--occupational hazard?


Better dentist-laboratory relations. I. The dental laboratory industry today.


Lucy Hobbs, first women dentist.

Lucy Hobbs, first women dentist.


Better dentist-laboratory relations. II. The dentist and his laboratory.


The general practice saves their teeth.

The general practice saves their teeth.


When con men zero in on the dentist.

When con men zero in on the dentist.


Independent learning center: Naval Graduate Dental Schoool.


Respirator cartridge efficiency studies. IV. Effects of steady-state and pulsating flow.


Genetic and environmental factors in schizophrenia. A study of schizophrenic twins and their families.


Radiation and drug therapies, and leukemia.


How to sharpen the harpoon of an aspirating syringe.


How to test for bleeding time.

How to test for bleeding time.


Maintaining morale in orthodontic patients.


The equal rights amendment to the United States Constitution.


Health planks differ, but not national objective.


The effect of insulin-induced hypoglycemia on NaCl hunger in the adrenalectomized rat.


A practical approach to molar root canal therapy.


The use of fiber optics as a diagnostic aid.


The secret of Sharlene's new smile: her own teeth in natural dentures.


Orthodontics for the G.P.: problems and priorities.


Total rehabilitation of the cleft lip-cleft palate child.


Hospital dentistry: when it's a must.

Hospital dentistry: when it's a must.


Simulating preventive dentistry in the community perspective.


Case report: 3-D radiography.

Case report: 3-D radiography.


Modern offices.

Modern offices.


Behaviors and attitudes: implications for dental health education.


Tissue conditioning: step by step technic.


Creating a favorable environment to condition apprehensive patients.


Was tetanus death linked to denture?

Was tetanus death linked to denture?


"Tongue thrust" therapy: a position statement.


Projecting the future of dentistry and its auxiliaries.


Pulp care.

Pulp care.


Diet, nutrition and the elderly edentulous patient.


The dentist and his personal insurances.


A general review of the study of pain.

A general review of the study of pain.


The influence of stannous fluoride on compressive, tensile and shear stresses and micro-structure of dental amalgam.


The determination of the normal vital response of pulp tissue by means of electrical and thermal stimuli.


Local effect of applying aluminum chloride on the dento-gingival unit as a tissue displacement material.


Studying occlusal changes in cured acrylic resin dentures.


Incidence and identity of micro-organisms present in the root canal.


Simulated loading of the temporomandibular joint.


A new approach for determining the occlusal vertical dimension.


Sickle cell anemia: history and clinical findings.


Peer review--a professional responsibility.


Dentistry and its problems.

Dentistry and its problems.


Dental disease control, home treatment program: case report of patient with severe gingivitis and rampant caries.


Third party--friend or foe?

Third party--friend or foe?


Mandatory continuing study--hits and misses.


Auxiliary training--the time is now.

Auxiliary training--the time is now.


Lichen planus. History and clinical findings.


Small city practice with specialized slant using multi-auxiliaries.


Group practice in suburban Chicago.

Group practice in suburban Chicago.


Efficient two dentist, multi-auxiliary office.


The rate of weight gain of the Mongolian gerbil. (Meriones unguiculatus).


Evaluation of drug utilization by dental patients. I. Drugs prescribed in a dental clinic for home use.


Gutta percha techniques for filling canals of young permanent teeth after induction of apical root formation.


The evaluation of a corticosteroid antibiotic agent in pulp capping.


Pigmented lesions related to dentistry.

Pigmented lesions related to dentistry.


Flaming as a means of sterilisation.

Flaming as a means of sterilisation.


Mixed dentition orthodontic treatment.

Mixed dentition orthodontic treatment.


Biostatics in dentistry.

Biostatics in dentistry.


Indestructible study models.

Indestructible study models.


Caries exam reminder.

Caries exam reminder.


Problems associated with removable orthodontic appliances.


A portable rotary dental prophylaxis instrument.


A protective coating for combating decalcification in orthodontic practice.


Preventive dentistry primitive style: a case history.


Precision placement of Edgelok brackets.


Does organized dentistry need a union?

Does organized dentistry need a union?


Gilles de la Tourette's syndrome; international registry.


The dislocating jaw.

The dislocating jaw.


Acute promyelocytic leukemia in a patient with hemophilia. Evidence for rapid consumption of clotting factors.


125 I-labeled rat transplantation alloantibody. II. Studies on antibody identity and comparative antigen site numbers per cell.


Examination of the chest: advantages of conducting and reporting it in English.


Orbital complications of acute sinusitis.


Squamous carcinoma of nasopharynx in a child.


Discussion of paper by Frances Pascher, M.D.: systemic reactions to tropically applied drugs.


Purification of oncornaviruses by agglutination with concanacalin A (murine leukemia virus-phytohemagglutinin-friend virus). Concanavalin A (Con A) has been used to rapidly and selectively agglutinate murine and avian oncornavirions from culture medium or plasma. The agglutinated virus was concentrated rapidly and gently by low-speed centrifugation and solubilization with alpha-methyl mannoside. Infectious virus was purified 2.3 times with respect to nucleic-acid content, and more than 60% of its infectivity was recovered. Infectious particles of densities 1.18 and 1.16 g/cm(3) were found in mouse cells infected with Friend virus. Con A reacted only with particles of density 1.16 g/cm(3), indicating heterogeneity with respect to carbohydrate content or structure as well as buoyant density. Electron microscopy of virus agglutinated with Con A showed a zone of Con A-glycoprotein complexes averaging 12-15 nm in thickness.


Acetylation of sickle cell hemoglobin by aspirin. Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with (14)C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs in vivo, administration of aspirin might ameliorate the severity of sickle cell disease.


Membrane intercalated particles in human erythrocyte ghosts: sites of preferred passage of water molecules at low temperature. Although hydrophilic pores have been inferred to account for characteristics of the movement of water molecules across erythrocyte membranes, no direct evidence has associated such pores with actual structural differentiations within the membrane. Freeze-fracture and freeze-etch studies of isolated erythrocyte membranes show that they are comprised of fluid bilayer domains tranversed by protein-containing intercalations ("membrane intercalated particles"). It has previously been hypothesized that the topology of the polar and apolar spaces of the membrane-intercalated particles was not concentric the hydrophobic spaces being equatorially distributed. In consequence, axial organization of the hydrophilic regions could result in hydrophilic continuity across the membrane and might provide a structural basis for passage of hydrophilic molecules. The present experiments support this hypothesis. It is shown that sublimation at -100 degrees of erythrocyte membrane suspensions (that had been incubated at pH 5.5 to cause aggregation of the membrane particles) results in progressive and selective sinking of the membrane regions comprised of aggregates of intercalated particles, i.e., that sublimation of water molecules occurs preferentially across these membrane regions. These results indicate that, under these experimental conditions, the membrane-intercalated particles provide a preferential structural pathway for passage of water molecules across erythrocyte ghost membranes.


Countercurrent separation: a new method for studying behavior of small aquatic organisms. A new method for the analysis of behavior in small free-swimming aquatic organisms is described. In this procedure, called countercurrent separation, a dense solution flows down along the bottom of an inclined chamber while a light solution flows in the opposite direction, upward along the top of the chamber. The attraction of animals (injected into the center of the chamber) to one solution or the other is then determined by observing the proportion of animals that emerges from the chamber in that solution. When used with the nematode Caenorhabditis elegans, it is estimated that the apparatus is equivalent to at least nine theoretical plates.


Cats reared in stroboscopic illumination: effects on receptive fields in visual cortex. Cats were reared in a light-tight box in which the only source of illumination was a 9-musec strobe flash every 2 sec. This allowed them to experience visual form but they did not experience visual movement. Receptive-field properties of single units in area 17 of the visual cortex of cats reared in stroboscopic illumination (strobe-reared) were compared with properties of units in area 17 of normally reared cats. In strobe-reared cats both direction selectivity and orientation selectivity were greatly reduced relative to normally reared cats, and some units in the strobe-reared cats responded only to strobe flashes.


A polypeptide region of bovine prothrombin specific for binding to phospholipids. The blood-clotting protein prothrombin can be converted to thrombin in free solution by the proteolytic enzyme, activated factor X. When prothrombin is bound to the surface of phospholipid vesicles, the rate of thrombin generation is increased more than 30-fold over the rate of unbound prothrombin. If the prothrombin activation process is terminated after a time interval in which less than 10% of the expected thrombin has been produced, two major products are found in the activation mixture. These products have been termed intermediate 1, a precursor of thrombin, and fragment 1. The conversion of intermediate 1 to thrombin is not accelerated by phospholipid nor can binding of this intermediate to phospholipid particles be demonstrated. In contrast, fragment 1, the other activation product derived from prothrombin, binds to phospholipid particles under the same conditions as prothrombin. On the basis of these observations, we propose that the prothrombin molecule contains a specific region of polypeptide chain for binding to phospholipid particles. This specific polypeptide region or lipid interaction site is part of the nonthrombin-forming activation fragment.


Sugar effects on murine sarcoma virus transformation. Transformation of NIH Swiss mouse fibroblasts by a murine sarcoma virus was influenced by the type of carbohydrate in the culture medium. Exposure to D-mannose and 2-deoxy-D-glucose caused a reduction in the number of transformed colonies in vitro and tumor formation in vivo. This is a new type of interference in the transformation process, manifested also by the absence of the pronounced enhancement of hexose entry into transformed cells, characteristic of a sarcoma virus infection. The uptake of D-glucose, D-mannose, and D-galactose, was repressed by normal mouse cells grown in the presence of D-mannose and D-glucose in the medium, while uptake of the same sugars was derepressed in cells grown in media containing D-xylose, L-xylose, or L-arabinose. D-Galactose had an intermediate effect on hexose uptake and permitted derepression. In every case, enhancement of the primary transport by sarcoma virus transformation was consistently beyond that observed at any time in the derepressed control cells, demonstrating the occurrence of another mechanism of enhancement of hexose uptake after sarcoma virus infection.


Effects of continuous noise on avian hearing and vocal development. Continuous loud noice was used to mask auditory feedback from vocal behavior of male canaries. Single unit techniques demonstrate partial deafness after noise exposure. Longer exposure caused greater deficits, with losses of high-frequency sensitivity. Males raised in noise to 40 days of age, then deafened surgically, thus totally deprived of auditory feedback from vocalization, developed significantly fewer song syllables than birds similarly raised but left intact, to mature in quiet sound-insulated chambers. Males left longer in noise, to sexual maturity at 200 days of age, sang at first like surgically deafend birds, but then increased their song syllable repertoire after noise termination. Thus, in spite of the considerable deafness resulting from noise exposure, the deficit in syllable repertoire was corrected, presumably as a result of restoration of the birds' ability to hear their own song.


Isolation and characterization of HL-A variants in cultured human lymphoid cells. We have developed a procedure for immune selection in an established human lymphoid cell line based on HL-A, the major human histocompatibility locus. After a single brief exposure to selective conditions, HL-A2 variant clones were isolated from an HL-A2/HL-A3 heterozygous line. The variant clones occurred at a frequency of about 1 x 10(-6). The variant phenotype was stable during prolonged growth in the absence of antiserum after isolation. The variant sublines bound [unk] 1/1000 the HL-A2 antibody per cell as the parent line. Variation was specific in that expression of antigens not selected against was unimpaired. Loss of the chromosome bearing HL-A2 was excluded as the cause of variation because the variants, like the parent line, were heterozygous for phosphoglucomutase (EC 2.7.5.1) determined by structural locus PGM(3), which is linked to HL-A.


The reaction of N-iodosuccinimide with the goitrogens: a model for the active iodine of the thyroid gland. The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve as an interesting model for the "active iodine" of the thyroid.


Mutational analysis of a regulatory gene for morphogenesis in Schizophyllum. Knowledge of the structure and function of a complex gene regulating sexual development in the mushroom, Schizophyllum commune, has come from the analysis of various mutations in a chromosomal region known as the Bbeta incompatibility gene. This gene is one of two linked genes, Balpha and Bbeta, that together comprise the B factor which regulates a developmental sequence known as the B-sequence. The B-sequence is normally "turned off" unless alleles of different specificity of either Balpha or Bbeta are combined in a heterokaryon resulting from the mating of two individuals. Various mutations have been found in the Bbeta gene that range in effect from dominant, always-on, through a number of intermediate stages of changes in specificity and function, to recessive, always-off. There is evidence that the Bbeta gene operates via a positive control mechanism and involves at least four functions, one of which has been shown to be separable by recombination.


Interaction of  13 CO 2  and bicarbonate with human hemoglobin preparations. Formation of (13)C-resonances attributable to carbamino derivatives has been observed in human erythrocyte hemolysate preparations equilibrated with (13)CO(2) at 33 degrees . Carbamino formation is most marked in deoxyhemoglobin and at alkaline pH, and is very largely inhibited by the addition of 2,3-diphosphoglycerate or conversion to oxyhemoglobin. The prominent carbamino resonance at 30.0 ppm upfield of CS(2) is visible in the spectrum of packed, deoxygenated erythrocytes equilibrated in (13)CO(2). This chemical shift falls close to that observed with sperm-whale myoglobin and within 2 ppm upfield of that seen with simple amino acids and peptides. The bicarbonate-carbonate resonance near 33 ppm is broad in the hemoglobin preparations, which always contain some carbonic anhydrase, but becomes narrow in the presence of the carbonic anhydrase inhibitor, acetazolamide. The nuclear magnetic resonance condition of intermediate exchange rate with dissolved CO(2) (68.4 ppm) obtains in the absence of inhibitor. The process has marked consequences in reducing the spin-lattice relaxation time, T(1), of the bicarbonate resonance by more than 10 times. The deoxyhemoglobin carbamino resonance has a T(1) value of 700 msec, indistinguishable from that of the protein carbonyl resonance envelope.


Subunits of human chorionic gonadotropin: unbalanced synthesis and secretion by clonal cell strains derived from a bronchogenic carcinoma. Three clones of ectopic hormone-producing cells from a single human neoplasm (bronchogenic carcinoma) show different rates of synthesis and secretion of chorionic gonadotropin and its alpha and beta subunits. For each clone, the amount of one or the other subunit always exceeded that of the complete hormone molecule. These findings may be analogous to unbalanced immunoglobulin chain synthesis in certain forms of myeloma.


Receptor mobility and receptor-cytoplasmic interactions in lymphocytes. An analysis of the inhibition by concanavalin A of the mobility of lymphocyte surface receptors is used to construct an hypothesis on membrane receptor-cytoplasmic interactions. It is proposed that binding of multivalent lectins alters the interaction of an assembly of colchicine-binding proteins with lectin receptors and other receptors, and reciprocally that the state of the colchicine-binding assembly alters the mobility and distribution of surface receptors on the cell membrane. Observations of the effect of colchicine and related drugs on the inhibition of receptor mobility by concanavalin A lend support to this hypothesis. The proposed model has several implications for studies of the initial events of mitogenesis in lymphocytes as well as for cell-cell interactions in general.


The influence of nearest-neighbor amino acids on the conformation of the middle amino acid in proteins: comparison of predicted and experimental determination of  -sheets in concanavalin A. A 20 x 20 table of tripeptides has been compiled that may be used to locate beta-sheet breaking and alpha-helix breaking residues in proteins. It is based on the definition of an alpha-helical and a beta-sheet domain on the (varphi, Psi) map based on the occurrences of alpha-helices and beta-sheets in 12 known proteins whose sequence and three-dimensional structure have been determined. Each entry in the 20 x 20 table lists three numbers, the frequency of occurrences of the middle amino acid (n) in relation to its nearest neighbors (n - 1) and (n + 1) in the alpha-helical domain, the beta-sheet domain and outside these regions. The regions between two beta-sheet-breaking residues would be permissively beta-sheet regions. The sequence of concanavalin A has been examined in this manner and of the 13 beta-strands defined by x-ray crystallography, 10 were in agreement with the permissively beta-sheet regions and, in the remaining three, beta-sheet-breaking residues were the third in one, and the third, fourth, and fifth residues in another, and the sixth residue in the third from the beginning of the beta-strands. The findings provide strong support for the role of nearest-neighboring amino acids in determining secondary structure of proteins.


Organization of memory.

Organization of memory. A new learning algorithm is presented that may have applications in the theory of natural and artificial intelligence.


Carcinogen-induced chromosomal breakage decreased by antioxidants. Blood leukocyte cultures were incubated with antioxidants and the carcinogens sodium cyclamate and 7,12-dimethylbenz(alpha)anthracene in different combinations. There were 17.4% more chromosomal breaks in the group of cells treated with dimethylbenzanthracene only than in the untreated controls. The reductions in chromosomal breaks by the antioxidants were as follows: ascorbic acid, 31.7%; butylated hydroxytoluene, 63.8%; Na(2)SeO(3), 42.0%; and dl-alpha-tocopherol, 63.2%. Multiple chromosomal breaks were distributed equally throughout the experimental groups. Sodium cyclamate had only slightly more chromosomal breaks than the controls (11.6 compared to 10.9%). In the cyclamate groups treated with Na(2)SeO(3), 11.2% of chromosomes were broken. More acrocentric-type chromosomal breaks (21.7%) were seen in the untreated cells than the cells treated with cyclamate (3.4%) or dimethylbenzanthracene alone (4.8%). The carcinogen-treated groups had a higher percentage of meta breaks than the untreated controls.


Atypical pattern of utilization of amino acids for mitochondrial protein synthesis in HeLa cells. The capacity of HeLa cell mitochondria, either isolated or in intact cells, to incorporate different labeled amino acids into proteins was investigated. Eight amino acids (alanine, arginine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, and lysine), which include most of the charged polar ones, showed a very low amount, if any at all, of chloramphenicol-sensitive incorporation, relative to that expected for an "average" HeLa-cell protein. By contrast, the most hydrophobic amino acids (leucine, isoleucine, valine, phenylalanine, and methionine) were the most actively incorporated by HeLa mitochondria. The available evidence suggests that pool effects cannot account for this general pattern of utilization of amino acids; furthermore, this pattern is in good agreement with the known hydrophobic properties of proteins synthesized in mitochondria.


Concerted formation of the gel of hemoglobin S. Apparent weight-average molecular weights of hemoglobin A and hemoglobin S were measured at high concentrations by equilibrium ultracentrifugation. Carbonmonoxy-hemoglobin S appears to exist as a solution of unassociated molecules, as do carbonmonoxy-and deoxy-hemoglobin A. Deoxy-hemoglobin S, however, exists in a gel-like state at concentrations above 14 g/dl, but no aggregates smaller than the gel were observed in solutions that were in equilibrium with the gel. Carbamoylation of hemoglobin S produced a solution of unaggregated molecules, as did cooling of uncarbamoylated hemoglobin S to 5 degrees . It is concluded that the gel of hemoglobin S is formed in a stoichiometrically concerted manner, and that the size of the smallest stable aggregate is greater than 20 hemoglobin molecules.


Differential transport of protein in axons: comparison between the sciatic nerve and dorsal columns of cats. Fast axoplasmic transport was studied in dorsal root ganglion cells of the cat. Proteins carried in the fast axoplasmic flow were labeled after an intraganglionic injection of (L)-[4,5-(3)H]leucine. The rate of transport was 380 +/- 26 mm/day in both the central and peripheral branches of the bifurcating axons that arise from cells of the dorsal root ganglion. The amount of radioactivity transported centrally, through the dorsal roots into the spinal cord, was about 50% of that moving peripherally, through the sensory fibers of the sciatic nerve. Labeled material appears to be transported principally in a bound form, as 70-80% of the radioactivity was insoluble in 0.01 M potassium phosphate buffer at pH 7.4. With multiple extractions, a fractionation procedure was developed by which 94-96% of the total transported radioactivity could be solubilized. The proteins carried by fast axoplasmic transport through the dorsal columns and through the sciatic nerve were compared by electrophoresis of extracted fractions on Na dodecyl sulfate-polyacrylamide gels. Different patterns of radioactivity are seen in the electrophoretograms, suggesting that the cells of the dorsal root ganglion may possess the ability to commit different proteins to transport through two branches of a single bifurcating axon.


Biosynthesis of reticulocyte membrane proteins by membrane-free polyribosomes. Intact rabbit reticulocyte cells synthesize two predominant species of membrane polypeptides; at least 10 reticulocyte membrane polypeptide species are not produced by the cells. Cell-free extracts of reticulocytes, free of any membranes or membrane-bound polyribosomes, synthesize large amounts of these two membrane polypeptides; one of these polypeptides appears to be modified, probably by loss of 20-40 amino acids, after it is incorporated into the membrane. Deprivation of hemin results in inhibition of synthesis by lysates of membrane proteins, globin, and all other cytoplasmic proteins.


Multiple repressor binding at the operators in bacteriophage lambda. Short DNA duplexes are protected when lambda DNA is digested with nuclease in the presence of lambda repressor. As the ratio of repressor to operator is increased, six successively larger fragments are recovered, ranging in size from 35 to 100 base pairs, each of which binds repressor. Study of these fragments indicates that, at each of the two lambda operators (o(L) and o(R)), repressor first binds to a unique site (not necessarily terminal), and that five additional sites are then filled in linear right-ward or left-ward order. The nucleotide sequences and affinities for repressor of o(L) and o(R) are not identical, although six fragments of similar size are protected at each operator. Evidence is presented arguing against the existence of hairpin-like structures in the operator fragments, and, moreover, it is shown that the operator duplex does not unwind when repressor binds to it.


125 I-labeled DNA-RNA hybrids in cytological preparations. RNA complementary to bulk humanplacental DNA was synthesized in vitro both in the presence and absence of (3)H-labeled ribonucleotides. The (3)H-labeled RNA was used directly for hybridization to the DNA of human metaphase chromosomes, whereas the unlabeled complementary RNA was labeled chemically with (125)I before hybridization. A comparison of autoradiographs produced by either isotope revealed no qualitative differences in the chromosomal annealing sites of the same population of RNA molecules. Since (125)I-labeled nucleic acids give similar, if not identical, results as do (3)H-labeled nucleic acids in in situ hybridization experiments, their use should make possible the localization of genetic elements for which tritium labeling methods are either inadequate or not possible.


Heme proteins: effect of an intermediate on photochemical behavior. This paper analyzes, in terms of a triangular kinetic scheme, the possible effects of an intermediate in the photochemical behavior of simple heme proteins. Both steady-state and transient phenomena are analyzed. The magnitude of the quantum yield for a given system is determined by a competition between quenching and ligand detachment, measured by the two rate constants, kappa(-1) and kappa(2), respectively; as a first approximation, it can be described by a single parameter, namely the ratio kappa(-1)/kappa(2). The individual values of kappa(-1) and kappa(2) can only be determined at light intensities so high that the measured quantum yield becomes itself a function of light intensity. Under these conditions the relaxation time for transient approach to the steady-state can be complex, corresponding to heavily damped chemical oscillations. It is pointed out that when the model is extended to include more than one intermediate, multiple oscillations are possible. In this more general case the system in the steady-state may also show pseudocooperativity or anticooperativity.


Attachment of chloroplast polysomes to thylakoid membranes in Chlamydomonas reinhardtii. Treatment of synchronous cultures of Chlamydomonas reinhardtii with chloramphenicol at 4 hr after the beginning of the light phase led to a preferential loss of 70S ribosomes from the 17,000 x g(max) supernate. The "lost" 70S ribosomes were found associated with a thylakoid membrane fraction prepared from the 17,000 x g(max) pellet. Electron microscopic examinations of this fraction revealed that the 70S ribosomes were bound to the unstacked regions of the thylakoid membranes as polygonal penta- and hexamers. These bound ribosomes were only released by treatment with 500 mM KCl and puromycin, suggesting that both ionic interactions and nascent peptide chains were involved in the ribosome-membrane attachment. Since growth of the thylakoid membranes occurs in the light, it is suggested that bound chloroplast ribosomes function in the synthesis of thylakoid membrane proteins.


Carbon-13 nuclear magnetic resonance spectra of prostaglandins and some prostaglandin analogs. High-resolution pulsed Fourier-transform nuclear magnetic resonance spectroscopy at 22.63 MHz was used to observe the proton-decoupled natural-abundance (13)C nuclear magnetic resonance spectra of CDCl(3) solutions of the methyl esters of prostaglandins F(1alpha), 15-epi-F(1alpha), F(2alpha), F(2beta), E(2), A(2), 13-dehydro-F(2alpha), 13-dehydro-F(3alpha), two intermediates on the synthetic pathway to 13-dehydro-PGF(3alpha), and of 7-oxa-PGF(1alpha). All resonances were assigned by chemical shift comparisons and single-frequency offresonance proton decoupling. With two exceptions, all the lines of the spectra are well-resolved single-carbon resonances. Those due to the cyclopentane and vinyl carbons are most sensitive to structural changes. Some of these effects can be rationalized in terms of the preferred conformations of the molecules.


Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments. HL-A 2 and HL-A 7 antigens have been solubilized from cultured human lymphocytes by papain and purified on a small radioactive scale after formation of immune complexes, or on a large scale by column chromatographic methods. In both cases, it has been shown that the materials obtained consist of two noncovalently bound fragments. One fragment is a glycopeptide of molecular weight 30,000-31,000, the other is a peptide of molecular weight 11,000-12,000. In polyacrylamide gels containing 8 M urea, the large fragments of HL-A 2 and HL-A 7 exhibited different electrophoretic mobilities, while the small fragments were the same. The relationship of these materials to the native HL-A molecule is discussed.


Treatment of Parkinsonism with L-dopa and decarboxylase inhibitors. An electrophysiological study.


Treatment of Parkinsonism with a combination of levodopa and the decarboxylase inhibitor and RO 46-4602 (a comparison with levodopa treatment alone).


Administration of amandine to patients on optimum L-dopa dosage.


Treatment of Parkinsonism with a compound of L-dopa (Larodopa R) and a decarboxylase inhibitor (RO-46-4602).


Treatment failures with L-dopa in Parkinsonism.


Effects of L-dopa on plasma growth hormones and insulin.


Plasma testosterone content of male patients with Parkinson's disease during L-dopa treatment with or without dopadecarboxylase inhibitor.


Long-term treatment of Parkinsonism with L-dopa.


Lipid composition on substantia nigra in Parkinson's disease.


Acetylcholinesterase activity of different brain areas in Parkinson's disease.


Observations in a family with dominant type of cerebellar ataxia.


Traumatic cerebellar lesions among brain-injured veterans 20-30 years after the injury. A follow-up study.


Infratentorial gas encephalogram and mental retardation.


Spontaneous intracerebellar haemorrhages.


Hereditary cerebellar ataxia associated with congenital cataracts. 4 cases of the Marinesco-Sjögren syndrome with some unusual features.


Spastic paraparesis associated with optic atrophy in monozygotic twins.


Hereditary cerebellar affections.

Hereditary cerebellar affections.


RNA in the cerebellum of the cat during postnatal development and the effect of specific physiologic stimulation.


Infectious, inflammatory, and immunological diseases in the nervous system. Clinical aspects.


Measles antibody in serum of multiple sclerosis patients, their children, siblings and parents.


A case of benign multiple sclerosis, with autopsy.


Histocompatibility (HL-A) antigens associated with multiple sclerosis.


Basic (encephalitogenic) proteins as vulnerable part in early myelin breakdown.


Agarose-electrophoresis of spinal fluid.


Measles antibodies and immunoglobulins in serum and cerebrospinal fluid in subacute sclerosing panencephalitis.


Clinical features of progressive and relapsing types of idiopathic polyneuritis.


Demyelination in subacute sclerosing panencephalitis. Ultrastructural and neurochemical observations.


Relapsing herpes zoster myelitis.

Relapsing herpes zoster myelitis.


Biochemical studies on human peripheral nerve myelin.


Cerebral blood flow, cerebral metabolic rate of oxygen and CSF acid-base parameters in patients with acute pyogenic meningitis and with acute encephalitis.


Origin of some proteins of human myelin.


A study of acute head injuries treated with "non-gap"-rehabilitation.


Collateral circulation during clamping of the carotid artery in patients subjected to carotid endarterectomy. The interrelationship between regional cerebral blood flow, internal carotid artery stump pressure, and EEG.


Critical levels of cerebral blood flow and oxygen consumption.


Clinical, histological and electromyographical studies in chronic alcoholics.


Prolonged hypocapnia used therapeutically in acute, focal brain lesions.


Treatment of spasticity with intrathecal block with phenol under myelographic controls.


Cerebral blood flow, EEG and psychometric variables related to clinical findings in presenile dementia.


Rehabilitation of patients with epilepsy. A preliminary report.


Some preliminary studies of methods for recording disturbances of movement of the upper extremities.


The concentration of carbamazepine (Tegretol R) in serum and in cerebrospinal fluid in patients with epilepsy.


Vibratory perception during ischaemia in chronic liver disease.


Lioresal and spasticity.

Lioresal and spasticity.


Long-term recovery functions of occipital and vertex recorded visual evoked potentials.


Lip-protein patterns in cerebrovascular disorders.


The patterns of S-LDH isoenzymes and S-GOT after traumatic brain injury.


Juvenile amaurotic idiocy in Denmark.

Juvenile amaurotic idiocy in Denmark.


Cerebrospinal fluid erythrophages and iron containing cells in cerebrovascular diseases.


Sensory nerve conduction during ischaemia in normal subjects and patients with chronic liver diseases.


Thermographic method for application in clinical neurology.


Recurrent haemorrhage and haemostasis in patients with ruptured intracranial saccular aneurysms.


Tolerance of the cerebral circulation to changes in blood pressure. Implications for the treatment of patients with arterial hypertension.


Intraventricular application of water soluble contrast media. An experimental study in cats.


The biochemistry of aspartylglycosaminurias.


Studies on the effect and mechanism of a Gaba derivative (Lioresal R) in spasticity.


The effect of Flavoxate R on neurogenic bladder dysfunction.


Genetic factors in febrile convulsions. A twin study.


Studies on sympathetic control of cerebral circulation.


Extracranial monitoring of intravenously given 75 Se-selenomethionine in the diagnosis of "cerebral death".


One daily dose of diphenylhydantoin (DPH) to patients with epilepsy.


The "kinki" disease of Menkes.

The "kinki" disease of Menkes.


Central pains.

Central pains.


Spectral properties of human lysozyme and its inhibitor complexes. Fluorescence and difference spectra.


Thermoregulation in the spinal man.

Thermoregulation in the spinal man.


Toxemia of pregnancy. The North Carolina Baptist Hospital experience (1966-1970).


Emergency transvenous pacing in the community hospital.


Physician involvement in drug abuse services in Forsyth County.


Monoamniotic twin pregnancy; a case report.


Conformity of audiometric systems with federal noise regulations.


Rotating dental interns.

Rotating dental interns.


Management of arrhythmia.

Management of arrhythmia.


Rest and ambulation in myocardial infarction. Evaluation of current therapy.


Bronchial asthma and intestinal parasites.


The hospital and comprehensive health care.


Wounds of neck. Treatment by prompt exploration.


Boosted dose metronidazole therapy in acute necrotising ulcerative gingivitis.


Basal ganglia calcification in postoperative hypoparathyroidism.


The right to die with dignity.

The right to die with dignity.


External cardiac resuscitation. Experience in community hospital emergency department.


Medical team at Grand Prix. Example of preparedness.


Factors influencing calculus formation. 1. Study plan and selected screening results.


Dentistry and medical health.

Dentistry and medical health.


Systolic time intevals: a non-invasive method to determine left ventricular function. Current status, advantages and limitations.


Bedside criteria for discontinuation of mechanical ventilation.


Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy.


Nitroblue tetrazolium reduction. False positive and false negative results.


An optimistic look at psychiatric nursing.


An evaluation of the standardization of endodontic endosseous implant instruments.


Pulp studies after 2 per cent sodium fluoride treatment of experimentally prepared cavities.


Median mandibular cyst partially lined with pseudostratified columnar epithelium. Report of a case.


Taurodontism: familial tendencies demonstrated in eleven of fourteen case reports.


Bilateral transposed mandibular teeth.

Bilateral transposed mandibular teeth.


A tiny supernumerary.

A tiny supernumerary.


Synthesis and fate of glycoprotein in rat oral mucosa 3  as observed by light electron microscopic radioautography with L-fucose-H.


Fibrosarcoma of the mandible. Report of a case.


Numbness--a significant finding.

Numbness--a significant finding.


Stomatitis areata migrans.

Stomatitis areata migrans.


Circumpalatal wiring.

Circumpalatal wiring.


The incidence of fissured tongue among 4,009 Iranian dental outpatients.


Palmar-plantar hyperkeratosis and concomitant periodontal destruction (papillon-lefèvre syndrome).


Central and peripheral fibrogenic and neurogenic sarcoma of the oral regions.


Gingival and pharyngeal metastasis from a malignant melanoma. Report of a case.


A case in forensic odontology: a bite-mark in a multiple homicide.


Autoradiographic studies of the intracanal diffusion of aqueous and camphorated parachlorophenol in endodontics.


Respirator and the nursing management of a patient on respirator.


Growth characteristics of a transferable acute leukemia in rats.


Autopsy case report.

Autopsy case report.


A dimethyltryptamine-forming enzyme in human blood.


Triplet pregnancy.

Triplet pregnancy.


Cyclic chemotherapy in acute lymphoblastic leukaemia of childhood: 5-year survivals.


Carcinoembryonic antigen in cancer of the female reproductive system: sequential levels and effects of treatment.


Serum heat stable alkaline phosphatase compared with urinary oestriol in abnormal pregnancy.


Reproductive failure after clomiphene induced ovulation.


The ultrastructure of molar trophoblast.


Experience with the suction curette in termination of pregnancy at a Sydney Teaching hospital.


Familial mediterranean fever, amyloidosis and pregnancy.


Traumatic amenorrhoea and cervical stenosis. Report of a case with successful pregnancy.


Primary carcinoma of the Fallopian tube. Case report.


Bone-marrow toxicity of methotrexate: a reassessment.


Observations on tissue fibrinolytic activity in patients with cutaneous vasculitis.


CAP: Criterion ability prediction clinical grading system.


DDS degree program for foreign dentists.


Effect of interviews on admission decisions.


Managerial characteristics of dentists. 3. Leader behavior description questionnaire.


Current trends and projections in dental education.


Change in attitudes of dental student during their professional education.


Medical school teachers--there is a message from an airline.


Association faces really tough issues: the President's Address.


Treatment evaluation in dental school clinic.


Selection of patients for dental students.


Restorative dentistry in the seventies.

Restorative dentistry in the seventies.


Experimental dental auxiliary programs.

Experimental dental auxiliary programs.


Accuracy of measurement of clinical performance in dentistry.


Community dentistry: student attitudes and priorities.


1. Audit report: Dental education, 1971-72, 1972-73.


Some dimensions of clinical teaching.

Some dimensions of clinical teaching.


Hydrogen sulfide production in the periodontal environment.


Toothbrushing frequency as it relates to plaque development and gingival health.


A plaque-free zone on human teeth--scanning and transmission electron microscopy.


Study of the effect of different prophylaxis frequencies on the periodontium of young adult males.


Diagnosis of gingival tumefactions.

Diagnosis of gingival tumefactions.


Periodontal disease in chimpanzees.

Periodontal disease in chimpanzees.


Perforations and ruptures of the esophagus.


Temporal arteritis: a review of the Washington Hospital Center experience with comparison of the literature.


Intractable ascites during maintenance hemodialysis.


Application of thermography in peripheral vascular diseases.


Peutz-Jeghers syndrome, case report.

Peutz-Jeghers syndrome, case report.


Chromosomal patterns in myelocytic leukemia.


Primary sarcomas of the temporal bone.

Primary sarcomas of the temporal bone.


A comparison of the eating in response to hypothermic and glucoprivic challenges after nigral 6-hydroxydopamine and lateral hypothalamic electrolytic lesions in rats.


United we stand.

United we stand.


Three primary malignancies occurring within fourteen months in the same patient.


How to set up a no-budget battered child program.


Memory change following EST and drug treated depression.


The calcified intervertebral disc. A non-specific roentgenologic sign.


Postlumbar puncture headache can be prevented.


Emergent surgery in the management of coronary artery disease.


New Jersey doctors' notebook.

New Jersey doctors' notebook.


Colony formation by mouse peritoneal exudate cells in vitro.


Rate of RNA synthesis in ghost monolayers obtained from fibroblasts preparing for division.


High oxygen affinity variant of haemoglobin Little Rock with unique properties.


Stereochemical interpretation of high oxygen affinity of haemoglobin Little Rock (  2   2  143His leads to Gln).


9-Cis isomerization of all-trans retinal during in vitro regeneration of visual pigment.


Cytological studies of fat-storing cells in the liver of rats given large doses of vitamin A.


Antigen solubilized from human solid tumours: lymphocyte stimulation and cutaneous delayed hypersensitivity.


Tetrodotoxin-resistant action potentials in newborn rat muscle.


Changing cytokinetic patterns of human leukaemic lymphoblasts during the course of the disease, studied in vivo.


Relationship between blast-cell morphology and occurrence of a syndrome of disseminated intravascular coagulation.


Practice administration.

Practice administration.


Your investments.

Your investments.


Learning to live with peer review. 1.

Learning to live with peer review. 1.


How to cure the overwork syndrome.

How to cure the overwork syndrome.


Breathe new life into your recall system.


Expanded duties? The hygienists are disturbed.


New concept in group practice.

New concept in group practice.


The dilemma of the Danish dentist.

The dilemma of the Danish dentist.


A better way to buy your building.

A better way to buy your building.


In search of dental research.

In search of dental research.


Vision: Telescopic, microscopic or tunneled.


Pulpal reactions to stannous fluoride as an anticaries agent.


Dental sensory mechanisms.

Dental sensory mechanisms.


Cementation of inlays.

Cementation of inlays.


The University of Iowa experimental program in dental hygiene.


Diagnosis of traumatic occlusion.

Diagnosis of traumatic occlusion.


Minority recruitment is a major project.


Reality sets in.

Reality sets in.


The future of the operating dental auxiliary in the United States.


Those undauntable dentists in Denver.

Those undauntable dentists in Denver.


Dental hygiene tomorrow too ... if we take the opportunity.


An eye for a tooth.

An eye for a tooth.


Opportunity--Innovation.

Opportunity--Innovation.


Meanwhile, back on the reservation.

Meanwhile, back on the reservation.


Implementing Federal legislation affecting dental auxiliaries.


Federal report on malpractice may affect dentistry.


Plaque control plus smoking control.

Plaque control plus smoking control.


Serial extraction vs. timely extraction.


Working together: it begins with staff motivation.


External resorption of unknown origin.

External resorption of unknown origin.


For the first time, she could have her cake and eat it too.


Case report: Treatment of fractured incisors.


A simplified procedure to end guesswork when checking occlusion.


Mixing procedure saves time, cuts waste.


Prevention by serial extraction.

Prevention by serial extraction.


Protection of dental personnel through proper mercury hygiene.


Modern offices: equipping the first office for economy in the long run.


Denturist activity poses growing challenge for dental profession and laboratory industry.


Endosseous blade implants for the G.P.: case report.


An implantologist looks at the state of the art.


What to do if patient death occurs in the dental office.


Disease-control program: success depends on follow through.


Training the new auxiliary: learn-by-doing is best.


A practical medical history form and how to use it.


Technic for the repair of acrylic resin veneers and incisal fractures.


For future re-design: no load-bearing walls.


The vitreous endosteal implant: a single tooth replacement system.


Effect of extended storage on aqueous solutions of stannous fluoride.


Triple threat to high quality dental care.


Epidemiological studies of dental disorders in Tamil Nadu population. 1. Prevalance of dental caries and periodontal disease.


Dental malpractice.

Dental malpractice.


Dentigerous cyst from supernumerary tooth in the nasal cavity.


Inflammatory potential of root canal sterilizing agents.


Unilateral condylar hyperplasia of the mandible.


Clinical pathological conference no. 21: pemphigus vulgaris.


A contemporary consciousness: directions for a profession. Why should dentistry have an association? Why should you belong to it?


Dental evidence in forensic medicine.

Dental evidence in forensic medicine.


New Zealand dental nurse report.

New Zealand dental nurse report.


Oral lichen planus and diabetes: a potential syndrome.


Complex odontoma of the mandible.

Complex odontoma of the mandible.


Incidence of torulopsis glabrata in oral cavity.


The dentist and total patient care.

The dentist and total patient care.


Medication hazard in dentistry. I.

Medication hazard in dentistry. I.


Mouth rehabilitation. Case presentation.


Hospital dentistry as it affects the medical community.


Why hospital dentistry?

Why hospital dentistry?


Dental arch shape--genetics or environment?


Histochemical observation of soft tissue ameloblastoma.


Diammine silver fluoride and its clinical application.


Life cycle of the gingival epithelium in experimentally induced chronic marginal gingivitis in mice.


Effect of SrF2-containing indirect pulp capping material on remineralization of artificially decalcified dentin.


Relation of clinical findings to imino acid contents in collagenous protein of inflamed human gingiva.


[Formaldehyde content of dental pulp of dog by pulp devitalization using paraform].


Ameloblastic fibroma and ameloblastic sarcoma--a report of the cases, histopathology and histochemistry.


Cytotoxicity of human peripheral lymphocytes for glioma, osteosarcoma, and glia cell lines.


Results in caries prophylaxis research.

Results in caries prophylaxis research.


Endocarditis prophylaxis in the susceptible dental patient.


Apparent drug addict seeks narcotic in dental office: a case report.


A general practitioner's viewpoint of the team concept developed by the dental manpower center.


Prescribing and the dental practitioner.


The selection and properties of materials for dental practice. 2. Dental cements and fissure sealants.


The maxillary antrum.

The maxillary antrum.


Persons or bodies found.

Persons or bodies found.


The oral mucous membrane markers of internal disease.


The attitude of patients to the wearing of a removable orthodontic appliance.


Removable appliance therapy. Patient co-operation and its assessment.


The selection and properties of materials for dental practice.


Syndrome of Gilles de la Tourette.

Syndrome of Gilles de la Tourette.


Splenectomy and leucopheresis in chronic granulocytic leukaemia.


Proposed criteria for nationally recognized accrediting agencies and associations.


Electrical stimulation of the brain as reinforcement of food consumption in aphagic cats.


Interprofessional consortium approach to developing auto-tutorial modules in basic health sciences.


Health appraisal of "apparently well" patient in oral diagnosis.


Determination of half value layer with Pb and  60 Co.


Emergency patients: source for learning oral diagnosis.


Learning model for clinical dentistry.

Learning model for clinical dentistry.


Congress is concerned about federal programs for health.


Summer job opportunities for dental students.


Proposal for reorganization of Council on Dental Education.


Comprehensive patient care in dental school clinic.


Accreditation: voluntary or federal.

Accreditation: voluntary or federal.


Hyppothalamic inhibition of chemoreceptor-induced bradycardia in the cat.


Orthodontic education in the United States.


Muscle pressures and tooth position. A review of current research.


Recognition and documentation of oral cleft conditions.


The challenge of gross malocclusions with the Begg technique.


Apples and gingival health. Report of a feasibility study.


The absorption of a constituent of some dentifrices and its effect on the properties of dental composite restorative materials.


Radiography and radiology for the dental practitioner. 2. Materials and processing.


Radiological protection in dentistry.

Radiological protection in dentistry.


The future of the odontological museum.

The future of the odontological museum.


An aid to surgery design.

An aid to surgery design.


The qualities of a good dental surgery assistant.


A new approach to oral hygiene for the cerebral palsy patient.


Iris involvement in leukaemia.

Iris involvement in leukaemia.


The pleasures of being busy.

The pleasures of being busy.


Timely topics--pre-planning your children's education.


Dr. James R. Hughes D.D.S. and the rescue patrol.


The dental firing line.

The dental firing line.


Intravenous sedation in dentistry: pentazocine.


Intravenous applications in dentistry.

Intravenous applications in dentistry.


Professional aspirations, job satisfaction and remuneration of expanded duty dental assistants.


Taking the bite.

Taking the bite.


Cases of interest. 2.

Cases of interest. 2.


The Gerber articulator and system of full denture construction. 2b. Setting-up the teeth and finishing the dentures.


Preparation of orthodontic study models.


Dimensional characteristics and developmental changes of the dental arches in the primary and mixed dentitions in spastic children.


Dental consultants to third party agencies.


Control of quality in dentistry.

Control of quality in dentistry.


Excitation of lateral reticular nucleus neurones by collaterals of the pyramidal tract.


Education of dental health professionals.


The concept of prevention.

The concept of prevention.


[Studies on the compatibility of fluorides and common toothpaste components. 2. Experiments on the uptake of 18F and 113Sn on the enamel surface from the fluoride toothpaste and their effects on the acid resistance].


Clinical trial of carbamazepine in the management of trigeminal and glossopharyngeal neuralgia.


Comparison of antibacterial action of Milton's solution with mysteclin-V solution in infected root canal therapy.


Fluoridation in Kentucky--1951-1973.

Fluoridation in Kentucky--1951-1973.


Transplantation of teeth.

Transplantation of teeth.


Personal responsibility for the home care of the mouth and teeth.


Accuracy of silver plated mercaptan rubber impressions.


The flight for fluoridation in Indiana--and a case report.


Improved esthetics as a result of minor tooth movement in periodontal therapy.


The team program at the University of Maryland.


Some thoughts on microleakage and restorative dentistry.


Governor Reagen warns: "Nationalized health insurance in socialism".


Rampant caries as a result of latent bottle feeding in young children.


Emergency treatment of a fractured anterior tooth using ultraviolet activated sealant and restorative material.


The changing role of institutional dentists in the last decade.


A report on lesions diagnosed in the University of Oregon Dental School Biopsy Service 1972-73.


So you've been thinking about incorporating?


Dental health services in the Philippines (WHO assignment report). II.


Future of dental auxiliaries in Oregon.

Future of dental auxiliaries in Oregon.


The importance of health education services in dental public health.


Use of mat gold in gingival third cavities on buccal and labial surfaces (class V).


Project Help S.O.C. Stamp Out Cavities.

Project Help S.O.C. Stamp Out Cavities.


Impressions from the back of the classroom.


Precompacted, coined titanium endosteal blade implants.


Macroscopic and microscopic studies of endosteal bladevent implants (six month dog study).


Evaluation of twenty-seven implant dentures after thirteen to twenty years.


Attitudes of the consumers in the inner city toward health services.


The diabetic dental patient.

The diabetic dental patient.


Burkitt's lymphoma: report of a case from Miami, Florida.


Tribute to a pioneer dentist.

Tribute to a pioneer dentist.


Stamping out dentistry.

Stamping out dentistry.


Dr. Mahlon Loomis: Genius and born loser.


Bricks and mortar do not a good dental school make; but they help.


THSR interviews--from two-star general to dental dean. Robert B. Shira, D.D.S.


Emphasis on the patient--the oral health service department.


A new role for the mylohyoid nerve?

A new role for the mylohyoid nerve?


Dental litigation.

Dental litigation.


Disinfecting ventilators.

Disinfecting ventilators.


Evaluation of the new "Williams" anaesthetic filter.


The early diagnosis of monocytic leukemia based on a study of 91 cases.


Action of 5-bromodeoxyuridine on the induction of haemoglobin synthesis in mouse leukaemia cells resistant to 5-BUdR.


Identical substitution in Hb Ube-1 and Hb Köln.


Dominance of AKR lymphocytes in tetraparental AKR and CBA-T6T6 chimaeras.


Haploid gene expresion versus meiotic drive: the relevance of intercellular bridges during spermatogenesis.


Phorbol esters, fatty acids and tumour promotion.


Changes in the adenylate energy charge in human blood platelets induced by adenosine diphosphate.


Effect of different gibberellins on betacyanin synthesis and seedling growth in Celosia.


Changes in sodium transport induced by the injection of proteases into squid axons.


Denture relining material for home use. Report of a case.


Service livers of respirator cartridges versus several classes of organic vapors.


Specially designed table for the uniform irradiation of the central nervous system.


Copper and zinc concentration in the plasma of leukaemic children.


Intention myoclonus in acute leukaemia.

Intention myoclonus in acute leukaemia.


Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone.


Paroxysmal nocturnal hemoglobinuria in a case of chronic myeloid leukemia.


Congenital neutropenia: in vitro growth of colonies mimicking the disease. Congenital neutropenia is a lethal disease characterized by recurrent infections beginning in the neonatal period, absence of neutrophils in the peripheral blood, eosinophilia, and monocytosis. The bone marrow shows an apparent "maturation arrest" of the neutrophil series at the promyelocyte stage. Granulocytic colonies grown in vitro in soft agar medium show normal development of eosinophilic colonies and monocyte-macrophage colonies, but defective neutrophil maturation. The abnormal colonies observed contained only myeloblasts and promyelocytes. Thus, it seems to have been possible to mimic in vitro the abnormal differentiation that is observed in vivo.


Interpretation of the binding of carbon monoxide to hemoglobin under photodissociating conditions. An interpretation is given of recent experiments by Brunori et al. on the binding of carbon monoxide by hemoglobin under photodissociating conditions. It is shown that their results follow directly from scalable models for hemoglobin in which the protein-modulated interactions are separable from the ligand binding.


Temporal frequency changes of enzyme and chromosomal polymorphisms in natural populations of Drosophila. A comparative study of chromosomal and enzyme polymorphisms in Drosophila pseudoobscura and in D. persimilis was conducted from April 1971 to October 1972 by taking samples at monthly intervals in two different localities. Seasonal cyclic changes occur in the chromosomal polymorphisms. Significant changes occur in the frequencies of the enzyme polymorphisms; preliminary evidence indicates that some of these changes may also be cyclic. Natural selection is the main process responsible for the changes in both kinds of polymorphisms.


Occlusion of brain capillaries by endothelial swelling in mycoplasma infections. Occlusion of cerebral capillaries due to acute swelling of the endothelial cells has been demonstrated in the brains of turkeys with encephalopathy caused by Mycoplasma gallisepticum (S-6 strain) infection. Similar capillary lesions were seen in rats with rolling disease, caused by M. neurolyticum toxin. Such lesions may be the basis of ischemic necrosis of the brain.


Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone. Somatostatin, a peptide isolated from ovine hypothalamic tissue that inhibits the release of radioimmunoassayable growth hormone in vitro from rat or human pituitary cells or in vivo in rats, has the primary structure [Formula: see text]. The structure was established by submitting the carboxymethylated peptide, the carboxymethylated tryptic digest, and the chymotryptic digest of the peptide to Edman degradation. Degradation products were analyzed by amino-acid analysis, as well as in some cases by determination of N-termini by dansylation or by determination of phenylthiohydantoins by mass spectrometry.


The "trophic" value of foods.

The "trophic" value of foods. Foods must furnish (i) calories, which can readily be measured, and (ii) raw materials necessary for the building and maintenance of metabolic machinery which makes possible fuel utilization. We have called this "beyond-calorie" quality of food its "trophic" value. This concept has more unity than appears on the surface, and is capable of approximate measurement by biological testing as our experiments show. The trophic value of a food cannot be ascertained from food composition tables because only a smattering of the necessary information is commonly furnished. A food cannot support life if it is missing, or deficient with respect to, any one of the necessary nutrients. A tabulation which includes only a few nutrients-e.g., calcium, thiamin, riboflavin, niacin, phosphorus, and iron-can be woefully misleading, especially if these individual nutrients have been added by way of fortification. THE MEASUREMENT WE HAVE APPLIED TO A NUMBER OF FOODS IS POTENTIALLY VALUABLE FOR COMPARING SIMILAR FOOD PRODUCTS: two grains, two breads, two milk products, or for comparison of the same food grown, processed, or preserved in different ways. By using essentially this method we have found that barnyard eggs are somewhat superior to battery eggs, but that whether they are fertile or infertile makes no difference. We are of the opinion that extensive biological testing of many commercial food products is highly desirable to help promote human health and better internal environments for our cells and tissues.


An attempt at an integral interpretation of nerve excitability. A qualitatively consistent integral interpretation of biochemical, electrophysiological, and biophysical data on nerve activity is given in terms of a basic excitation unit. This operational term models a dynamically coupled assembly of membrane components accounting for graded and all-or-none responses upon stimulation. The analysis contains a series of suggestions linking controversial interpretations and is aimed at stimulation of experimental studies providing the basis for a quantitative integral theory of nerve excitation.


Protective effect of ascorbic acid on hepatotoxicity caused by sodium nitrite plus aminopyrine. The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.


Deviations from Hardy-Weinberg frequencies caused by assortative mating in hybrid populations. The conventional formulas for genotype frequencies in a hybrid population H produced by interbreeding from ancestral populations P(1) and P(2) involve only one hybrid parameter M, equal to the fraction of alleles derived from P(2). For the one-parameter model to be accurate, all individuals of H must have probabilities for alleles determined by one and the same M. When H contains subpopulations that have different values of M, the correct genotype frequencies can be predicted by use of two parameters: (i) M(H), the average of M for all individuals of H and (ii) eta(H), defined like the eta devised by C. A. B. Smith for testing the Hardy-Weinberg Law and computed with a formula like G. R. Price's eta, which involves assortative mating covariance-in this case for the M values of the parents of H. If parents of H have equal average M values for males and females, and mate at random, eta(H) vanishes. For perfect assortative mating, eta(H) is the variance of M for H. As for Smith's eta, eta(H) provides a test of fit of prediction to observed that is sensitive to signs of deviations. Using eta(H) with T. E. Reed's data for Gm in Oakland, California Negroes, his one-parameter fit ("good" by his chi-square test) is significantly rejected (P = 0.04). A simultaneous good fit of Reed's Gm data and his Duffy data results (chi-square, 1 df = 0.88, P > 0.30) from the use of previously published values of 0.23 and 0.047 for M(H) and eta(H). It is concluded that Reed's conclusion that these values were in error is itself in error, as is also his view that differences between M values from different genes and deviations from frequencies expected within genes are not likely to give significant information about variance of M.


Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid. L-2-Imidazolidone-4-carboxylic acid is an effective competitive inhibitor of the reaction catalyzed by 5-oxoprolinase, in which 5-oxo-L-proline (L-pyroglutamic acid, L-2-pyrrolidone-5-carboxylic acid, L-5-oxopyrrolidine-2-carboxylic acid) is converted to L-glutamate, with concomitant cleavage of ATP to ADP and orthophosphate. L-2-Imidazolidone-4-carboxylate decreased the rate of metabolism of 5-oxo-L-[(14)C]proline to (14)CO(2) by rat-kidney slices but had no effect on the metabolism of [(14)C]glutamate. Mice injected with L-2-imidazolidone-4-carboxylate exhibited greatly reduced ability to metabolize 5-oxo-L-proline, but metabolized glutamate at an essentially normal rate. The findings provide an approach to an animal model for the human condition 5-oxoprolinuria, in which there is apparently a deficiency of renal 5-oxoprolinase activity. The evidence indicates that 5-oxoproline is a normal metabolite.


Photoreversible conductance changes induced by phytochrome in model lipid membranes. The plant protein phytochrome induces photoreversible conductance changes when added to a black lipid membrane made from oxidized cholesterol. The conductance of the phytochrome-modified membrane is increased by red-light illumination but is decreased by illumination with far-red light. Denatured phytochrome does not affect the conductance of the model membrane.


Microtubule assembly in the absence of added nucleotides. Microtubule assembly is enhanced by the addition of 1 M sucrose or 4 M glycerol to the reassembly mixture. Tubulin can be purified from guinea pig brain readily and in good yield by two cycles of assembly in glycerol-containing solutions. The tubules assembled in glycerol and sucrose are more stable than tubules formed in the absence of these compounds. Assembly occurs in glycerol or sucrose in the absence of ATP or GTP, but is greatly accelarated by their presence.


Light-induced absorbance changes associated with phototaxis in Dictyostelium. Reversible light-induced absorbance changes were observed in the phototactic organism Dictyostelium discoideum. Irradiation of cells with light in the 520- to 600-nm region results in an absorbance increase at 411 nm, which decays in darkness with a half-time of about 7 sec. A similar light-induced absorbance change was observed in a 12,000 x g pellet of a cell-free homogenate and in a soluble fraction obtained after sonication of the 12,000 x g pellet. Dithionite had to be added to the cell-free extracts in order for the light-induced change to decay in darkness. The absorbance change was maximally elicited by light in the region of 560 nm. A similar spectral sensitivity was found for the phototactic migration of the pseudoplasmodia. The agreement between the spectral sensitivities of the two processes suggests that the absorbance change is associated with phototaxis.


Factor-promoted dissociation of free ribosomes in a rabbit reticulocyte lysate system: inhibition and requirement for an energy source. A factor that promoted the dissociation of ribosomes into ribosomal subunits in a complete globin-synthesizing system was isolated from rabbit reticulocyte ribosomes. The factor stimulated both globin synthesis and the association of the small ribosomal subunit with polyribosomes. The dissociation of free ribosomes by the factor could be followed as an independent reaction in the presence of a high concentration of cycloheximide, which inhibited translation and the resulting accumulation of runoff subunits. This reaction required an energy source and was inhibited by P-(5'-guanylyl)-methylenebisphosphonate. These data suggest that energy generated by hydrolysis of GTP may be a requirement for the dissociation reaction. Aurintricarboxylic acid inhibited the factor-mediated dissociation of free ribosomes but not the factor-mediated preservation of subunits formed on peptide-chain termination.


Role of medium-range interactions in proteins. The energies of oligopeptide segments of lysozyme are minimized with respect to the dihedral angles of the central residue. As the length of the oligopeptide segment increases, up to a nonapeptide, the low-energy conformation becomes that observed in the x-ray structure in most cases. This finding suggests that, while short-range interactions appear to play the dominant role in determining the conformation of an amino-acid residue in a protein, the additional interactions required to stabilize the conformation uniquely may be only of medium range, i.e., those within a nonapeptide, and longer-range interactions may be of considerably less importance.


Synaptic differentiation in a regenerating crab-limb muscle. Properties of synapses on regenerating nerve terminals of the single excitatory axon to the stretcher muscle were studied in the regenerating second walking leg of the shore crab, Grapsus. In the adult condition these synapses vary in physiological properties, ranging from high release, poorly facilitating types to low release, highly facilitating types. Synapses on regenerating stretcher-muscle fibers show a distinct temporal pattern of differentiation. In early limb buds, a characteristic fluctuating, excitatory postsynaptic potential, punctuated by failures of transmission, is seen, indicating a developmentally "naive" synapse with low quantal content. In these early stages proportionately more synapses are of the poorly facilitating type; the highly facilitating synapses appear increasingly in later stages. Thus, the type of synapse that will form seems likely to be related to the time of innervation. Synapses of early developmental stages found by electron microscopy are significantly smaller than those seen in adult muscles; thus, the synaptic contact area must increase during development. We postulate that contacts formed by the primary branches of the axon early in development differentiate into relatively large, poorly facilitating synapses, while contacts formed by secondary branches slightly later in development differentiate into smaller, highly facilitating synapses.


Immunoglobulin synthesis and secretion by cells in the mouse thymus that do not bear theta antigen. The mouse thymus contains cells that synthesize and secrete minute amounts of immunoglobulin (Ig). These cells were studied by a combination of cytotoxic tests (with alloantisera prepared in congenic strains of mice) followed by pulse labeling of the surviving cell population with [(3)H]tyrosine. The immunoglobulin-synthesizing cells constitute less than 2% of the total cell population and are theta(-), TL(-), Ly-B(-), Ig(+), H-2(+), and PC(+). Since this phenotype is not characteristic of cells of the thymocyte lineage, the Ig(+) cells are probably plasma cells and/or bone marrow-derived (B) lymphocytes. Similar studies of spleen cells indicate that immunoglobulin-synthesizing and secreting cells are theta(-).


A crystalline fragment of the double helix: the structure of the dinucleoside phosphate guanylyl-3',5'-cytidine. The sodium salt of guanylyl-3',5'-cytidine crystallizes in a monoclinic unit cell with one molecule in the asymmetric unit. Each molecule is related to another molecule by a 2-fold rotation axis which results in the formation of an antiparallel, right-handed double helix with complementary hydrogen bonding between the guanine and cytosine residues. The crystal is heavily hydrated with 36 water molecules in the unit cell. The geometry of this crystalline double helix is very similar to those which have been derived from studies of fiber x-ray diffraction patterns of double-stranded RNA, even though the latter do not yield data at atomic resolution.


The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement. The Ss-Slp region of the mouse genome is located between the two loci, H-2K and H-2D, of the major histocompatibility system. It controls the level of a serologically detectable serum globulin, the Ss protein, and its allotypic forms, Slp(a) and Slp(o). Evidence is presented that the Ss-Slp region is involved in control of the complement system. Mice of congenic resistant strains differing only at the H-2 gene complex show differences in complement levels. A comparison of H-2 recombinants demonstrated that complement level correlates with the Ss-Slp genotype and not with the H-2K, H-2D, or Ir genotypes. Among the 13 congenic strains tested, those with the Ss(h)Slp(a) allele had higher complement levels than those with the Ss(h)Slp(o) or Ss(l)Slp(o) alleles. Mice with recombinant H-2 haplotypes had complement levels similar to those of the parental strain that provided the Ss-Slp segment. It was also shown that anti-Ss serum inhibits complement activity of mouse serum in vitro.


Relaxation spectra of potassium channel noise from squid axon membranes. Power density spectra of electrical fluctuations in potential and current (during voltage clamp) in the steady state, measured from electrically isolated patches of squid axon membrane, contain a noise component that is of the form [1 + (f/f(c))(2)](-1). For potential and temperature changes f(c) = (2pitau(n))(-1), where tau(n) is the Hodgkin-Huxley relaxation time for the potassium channel. These and other data strongly suggest that this noise is due to the potassium ion passage process in the membrane. Furthermore, by comparison of the values of f(c) from relaxation spectra of membrane channel noise with those from calculated (Hodgkin-Huxley equations) power spectra, it is possible to relate and compare channel models that previously could only be applied to macroscopic potassium conductance data. An initial result of this comparison suggests that a two-state (open-closed) conductance model, which is based upon a literal interpretation of the Hodgkin-Huxley equations, is not likely to be correct.