Structure of hemoglobin S fibers: optical determination of the molecular orientation in sickled erythrocytes. Possible orientations of deoxyhemoglobin S molecules within sickle-cell fibers are delimited by polarized absorption measurements on single sickled cells and single crystals of deoxyhemoglobin A. The polarization ratio of cells provides a lower limit for that of an individual fiber and, coupled with the absorption properties of the deoxyhemoglobin molecule, restricts the orientation of the long molecular (x) axis to within 22 degrees of the fiber axis. Adopting the stacked ring model of Finch et al. for the molecular positions and the additional constraint that at least one mutated (beta6) site is part of an intermolecular contact, our optical result requires that the true molecular dyad (y) axis pass through some part of an adjacent molecule in the same ring. This range of orientations for the y axis is approximately perpendicular to those described in existing models and places at least one beta6 residue in position to be part of a contact between molecules in the same ring.


Isolation and partial characterization of alpha and beta-tubulin from outer doublets of sea-urchin sperm and microtubules of chick-embryo brain. Two kinds of tubulin (alpha and beta) have been described in microtubules from many different systems. In this study a discontinuous acrylamide-gel system containing sodium dodecyl sulfate was used to separate milligram quantities of alpha- and beta-tubulin from microtubules of chick-embryo brain and from outer doublets of sea-urchin sperm. The isolated tubulins were characterized by peptide mapping and automated sequencing of the first 25 NH(2)-terminal amino acids. Our results show that alpha- and beta-tubulin are related but distinctly different proteins and that each one has been highly conserved in the course of evolution.


The affinity-labeling of partially purified acetylcholine receptor from electric tissue of Electrophorus. The receptor for acetylcholine was partially purified by affinity chromatography of an extract in Triton X-100 of membrane fragments from electric tissue. The receptor was assayed, after its reduction with dithiothreitol, by reaction with the affinity-alkylating agent, [methyl-(3)H]4-(N-maleimido)-benzyltrimethylammonium iodide. Alternative labeling procedures, one useful for routine assay of picomole quantities of receptor and the other for labeling larger quantities of receptor, are described. The purified receptor specifically incorporated about 3 nmol of label per mg of protein. This incorporation was blocked by pretreatment of the receptor with Naja naja siamensis neurotoxin. The rate of the affinity reaction was similar to that found with membrane fragments and with intact electroplax. Furthermore, as in intact electroplax, [(3)H]4-(N-maleimido)-benzyltrimethylammonium iodide reacted 5000-fold faster with the reduced receptor than did [(14)C]N-ethylmaleimide. When purified receptor was labeled with [(3)H]4-(N-maleimido)-benzyltrimethylammonium iodide and subjected to electrophoresis on polyacrylamide gels in dodecyl sulfate and dithiothreitol, three major protein bands were observed. Only one of these, however, contained (3)H activity; its mobility indicated a molecular weight of 40,000.


Cell-free translation of the globin message within polydisperse high-molecular-weight ribonucleic acid of avian erythrocytes. Polydisperse high-molecular-weight RNA of nucleated avian erythrocytes includes sequences coding for globin chains. The RNA was extracted from immature erythrocytes of ducks and fractionated under denaturing conditions by sucrose density gradient centrifugation in 99% dimethylsulfoxide. The RNA sedimenting faster than 45 S was able to direct the synthesis of duck globins in the Krebs II ascites cell-free protein-synthesizing system. The newly synthesized globin molecules have been identified by their characteristic electrophoretic properties in polyacrylamide gels containing either urea or sodium dodecyl sulfate, and by immunoprecipitation of the released globin chains by rabbit antibodies against duck hemoglobin. In order to rule out the possibility of a contamination of the high-molecular-weight RNA with duck-globin messenger RNA tailing from the 9-10S region, rabbit-globin messenger RNA was added to duck RNA as an internal control. No rabbit-globin messenger RNA activity could be detected in the RNA fractions sedimenting faster than 45 S. It is concluded that high-molecular-weight RNAs in the nucleated erythroid cell contain sequences of globin messenger RNAs covalently attached to larger polynucleotide chains. These results support the view that polydisperse nuclear RNA is the precursor of the cytoplasmic messenger RNA fraction.


Cell-free synthesis of rat growth hormone. Growth hormone has been synthesized in a cell-free system derived from Krebs II ascites cells, under the direction of RNA prepared from rat pituitary tumor (GC) cells. Growth hormone synthesized in the cell-free system was identified by precipitation with antiserum against growth hormone developed in baboon, followed by electrophoretic analysis of the dissolved precipitate on sodium dodecyl sulfate-polyacrylamide gels. RNA from both the membrane and the post-membrane fractions of the cytoplasm of GC cells stimulated protein synthesis in the cell-free system, but only RNA from the membrane fraction was found to direct the synthesis of growth hormone.


Mitogenic properties of lectin and its chemical dervatives. A mitogenic lectin that has a carbohydrate-binding specificity similar to that of concanavalin A (Con A) can be isolated from pea seeds. Chemical modification (succinylation, acetylation, or treatment with the diazonium salt of sulfanilic acid), changes its biological properties. In mitogenic stimulation of mouse spleen cells and in hemagglutination, the differences between the chemically modified pea lectin and the native molecule are similar to those observed between succinyl-Con A and native Con A. However, whereas chemical modification converts tetrameric Con A to a dimeric molecule, similar treatments of the pea lectin do not change its quaternary structure. The results of binding studies of the pea lectin and its derivatives to mouse spleen cells suggest that the differences in biological activities may be explained by a reduction in binding affinity of the pea lectin for glycoproteins on the spleen cell surface after chemical modification.


Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2. The administration of tungsten to rats maintained on a low molybdenum diet resulted in a dose- and time-dependent loss of sulfite oxidase (EC 1.8.3.1) and xanthine oxidase (EC 1.2.3.2) activities and hepatic molybdenum. These tungsten-treated animals appeared healthy, but were more susceptible to bisulfite toxicity. The median lethal dose for intraperitoneal bisulfite was found to be 181 mg of NaHSO(3) per kg for the animals deficient in sulfite oxidase, compared to 473 mg/kg for normal rats. The survival time of rats exposed to SO(2) at concentrations of 590 ppm and higher was seen to be inversely related to the level of SO(2). At 590 ppm and 925 ppm, control animals displayed symptoms of severe respiratory toxicity before death. At 2350 ppm of SO(2), death was preceded by seizures and prostration, symptoms observed with the systemic toxicity of injected bisulfite. At 590 ppm, animals deficient in sulfite oxidase were indistinguishable from control animals. However, at 925 ppm and 2350 ppm, the deficient animals displayed symptoms of systemic toxicity and had much shorter survival times. It is concluded that sulfite oxidase is instrumental in counteracting the toxic systemic effects of bisulfite, either injected or derived from respired SO(2). Respiratory death probably results from the toxicity of gaseous SO(2) before absorption as bisulfite and cannot be alleviated by sulfite oxidase. Sulfite oxidase does not appear to be inducible by either bisulfite or SO(2).


Molecular nature of mammalian cell DNA in alkaline sucrose gradients. Mammalian cell DNA that exhibited anomalous sedimentation in alkaline sucrose gradients was examined directly by electron microscopy. Its appearance was that of duplex DNA. In addition, some duplex DNA was observed under conditions in which the sedimentation anomaly was no longer apparent. Persistence of double-stranded DNA under denaturing conditions suggests caution in the interpretation of changes in the molecular weight or conformation of DNA based solely on analysis of sedimentation profiles.


Manipulation of fatty acid composition in animal cells grown in culture. The fatty acid composition of animal cells cultured in serum-free medium can be manipulated when the synthesis of endogenous fatty acids is inhibited by a biotin analog and fatty acids are supplied in the medium as detergent esters of Tween. When mouse LM cells were grown in medium supplemented with Tween-19:0 (an ester of Tween and nonadecanoic acid), odd chain fatty acid content of cellular phospholipids and neutral lipids increased from 1% to 75%. Concurrently, the saturated fatty acid content increased from 27% to 85%. Similar alterations in fatty acid content have been observed when BHK(21) cells are subjected to the same enrichment regime. The ability to control the fatty acid composition of cultured animal cells is a prerequisite to investigations into the role of the membrane lipid physical state in processes unique to these cells.


Oral effects of the consumption of various sugars.


DNA polymerase 3 star requires ATP to start synthesis on a primed DNA. DNA polymerase III star replicates a varphiX174 single-stranded, circular DNA primed with a fragment of RNA. This reaction proceeds in two stages. In stage I, a complex is formed requiring DNA polymerase III star, ATP, spermidine, copolymerase III(*), and RNA-primed varphiX174 single-stranded, circular DNA. The complex, isolated by gel filtration, contains ADP and inorganic phosphate (the products of a specific ATP cleavage) as well as spermidine, polymerase III star, and copolymerase III star. In stage II, the chain grows upon addition of deoxynucleoside triphosphates; ADP and inorganic phosphate are discharged and chain elongation is resistant to antibody to copolymerase III star. Thus ATP and copolymerase III star are required to initiate chain growth but not to sustain it.


Defensive responses and reactions of the dental pulp.


Micro-repilication for scanning electron microscopy applied to clinical soft tissue diagnosis.


Dental "fingerprints" of some famous and infamous people.


The use of alloplastic materials in ridge augmentation.


Plaque prevention and removal by antimicrobial agents.


Human research models for the production and prevention of marginal periodontal disease and caries.


Gingival tissue reactions to plaque and dental restorations.


Review of use of implants in dentistry.

Review of use of implants in dentistry.


Clinical applications of endosseous implants.


Experimental evaluation of dental implants.


Circulation in oral tissues and clinical significance.


Peer review: Part II.

Peer review: Part II.


Emergency treatment of fractured incisors. A new approach.


Pulpal effects of concentrated phosphoric acid.


Elution technique to determine ABO blood group from human bone.


Antiphagocytic effects of the capsular structure of a pathogenic strain of Bacteroides melaninogenicus.


Double-blind evaluation of alclofenac for pain after extraction of tooth.


Pemphigoid...a treatment.

Pemphigoid...a treatment.


Myo-fascial pain dysfunction syndrome.

Myo-fascial pain dysfunction syndrome.


Recommendations for the use of topical fluoride self-application technics in a preventive dental office.


Simplified technic for removal of a fixed bridge.


Acupuncture: a dental case report.

Acupuncture: a dental case report.


Use of the band-arm fixed space maintainer.


Choosing and using drugs in emergencies.


Corrective endodontics following a misdiagnosis.


Special touches and "fun days" make office hum.


For better dental health...students counsel children on nutrition.


Health maintenance organizations--a future for dentistry?


The temporomandibular joint--standard observations in dry skulls.


The neurological relationship of bruxism and sleep.


Methods of replacing missing cornal dentin. Core and post care systems.


The dental health of Rhodesian negroes.

The dental health of Rhodesian negroes.


A clinical and laboratory evaluation of a new composite restorative material.


Clinical evaluation of depth of gingival sulcus of primary teeth.


Biochemical characters of strains of staphylococci isolated from human suppurative oro-facial infections.


Mast cells in normal and leukoplakic buccal mucosa.


Adeno-ameloblastoma. A case report.

Adeno-ameloblastoma. A case report.


Factors influencing calculus formation. II. Prospective clinical and laboratory studies.


Applicability of Angle's classification for surveys of malocclusion during the period of mixed dentition.


A study on messio-distal crown width of anterior teeth among north Indians.


Endoscopy of the maxillary sinus.

Endoscopy of the maxillary sinus.


Celesnik procedure in the surgical treatmewnt of bilateral complete clefts.


Variations of fibrous dysplasia in the jaws.


Results of immediate and delayed surgical treatment of facial fractures with diplopia.


The wear of dental materials: a review of the literature.


Who has ever thought about it?

Who has ever thought about it?


Community practice at the University of Michigan School of Dentistry.


Project dental health--the answer to low income care?


A component evaluates the ADA.

A component evaluates the ADA.


Plaque and the brush-in.

Plaque and the brush-in.


Patient motivation in preventive dentistry.


Dental plaque morphology and induction.

Dental plaque morphology and induction.


Editorial: The dental specialist.

Editorial: The dental specialist.


Cystic fibrosis: a review.

Cystic fibrosis: a review.


Law and economics of dental practice in Missouri.


Problems in prevention.

Problems in prevention.


Socialization in dentistry.

Socialization in dentistry.


Group practice--a better dental delivery system.


Immunological aspects of prevention.

Immunological aspects of prevention.


Expanded duties for auxiliaries explained by State Board.


Forensic dentistry.

Forensic dentistry.


So you've been thinking of incorporating? 2.


Dental pulp calcification as a response to the methods of treatment.


Thumbsucking.

Thumbsucking.


Risk management in practice administration.


Letter: Half-price dentistry.

Letter: Half-price dentistry.


Disadvantages of "contract practice".

Disadvantages of "contract practice".


The philosophy of successful endodontics.


The problem employee.

The problem employee.


Education and the technician.

Education and the technician.


Growing up--backwards.

Growing up--backwards.


How to shop for money.

How to shop for money.


Anaesthesia and intensive care.

Anaesthesia and intensive care.


Teratogenicity of drugs.

Teratogenicity of drugs.


Diseases of the domestic fowl in Northern New Zealand.


Letter: Kikuyu poisoning in sheep.

Letter: Kikuyu poisoning in sheep.


Letter: The use of fibreglass with plaster of Paris in the fabrication of casts.


Prenatal growth of the adrenal gland in sheep.


Cystic fibrosis.

Cystic fibrosis.


The control of the level of staphylococcal contamination of the bovine udder by shed management.


Inhibited development of Ostertagia spp. and Cooperia spp. in naturally acquired infections in calves.


Replication of occlusal anatomy.

Replication of occlusal anatomy.


Colitis X in the horse.

Colitis X in the horse.


Isolation of Salmonella victoria from a cow.


Letter: Fertility and production in dairy cows.


What's your diagnosis? Scleroderma.

What's your diagnosis? Scleroderma.


My thoughts, philosophies and contributions regarding implantological restorations for severely atrophied maxillae that are partially or totally edentulous.


What's your diagnosis, doctor? Fibrous dysplasia.


AMPS (accountability management planning system): an in innovative management system for the dental office.


Biomechanics.

Biomechanics.


Mandibular utility arch. The basic arch in the light progressive technique.


Computerized cephalometrics.

Computerized cephalometrics.


Craniofacial anomalies.

Craniofacial anomalies.


Seven position serial cephalometric appraisal of normal growth and/or treatment.


Neurology as a factor in orthodontics.

Neurology as a factor in orthodontics.


Analysis of directional headgears.

Analysis of directional headgears.


Effect of tonsils and adenoids on respiration, deglutition and phonation.


How to establish the optimum functional position of the mandible and eliminate dual-bites, and TMJ dysfunction.


Cranial growth forecast and treatment planning as related to the growth and development of the individual child.


Growth and behavior of the integumental profile.


Public relations.

Public relations.


Patient motivation.

Patient motivation.


Clinical and therapeutic aspects of impacted teeth. Operative removal of impacted mandibular third molars (Type II).


A difficult diagnosis.

A difficult diagnosis.


The preventive action of fluoride a solid-state effect.


Cooperation bbetween the dentist and the dental laboratory--harmonized materials as a base.


Hawley bite plate and its clinical importance.


Modifications of the Andresen-Häupl activator.


Stress situations in dental practice.

Stress situations in dental practice.


The hazards of passive smoking.

The hazards of passive smoking.


A technique: direct waxing of a partial veneer crown.


South Carolina dental manpower study.

South Carolina dental manpower study.


Trends in continuing education. Where are we now? Where are we going in South Carolina?


Mandibulo-facial dysostosis. A case report.


Homotransplantation and autotransplantation of teeth in humans.


Relationship of plaque and gingivitis in patients with leukemia.


Dental extern program; cooperative effort between MCV and VDA.


TV's effect on nutrition.

TV's effect on nutrition.


A report on priorities--dental care programs.


Preventive dentistry extension for promotion of periodontal disease?


Osteogenic sarcoma in the pig.

Osteogenic sarcoma in the pig.


Restoring fractured incisors in adolescent patients.


Group practice revisited: How it's working out now.


Modern offices.

Modern offices.


A nasal splinter of dental origin.

A nasal splinter of dental origin.


A report of the dentinal crazing producing rate between TMS pins and machinist's taps.


Studies on several enzymes of uronic acid pathway in human leucocytes under normal and leukemic conditions.


Idiopathic internal resorption. Report of a case.


Reliability of electric annealers for gold foil.


Modified rectilinear instruments for the modern amalgam preparation.


The effect of thymectomy on the fatty acid concentration of plasma, liver and fat pads.


A learned profession: "its responsibility".


The odontoma: study and discussion.

The odontoma: study and discussion.


Burnishing of amalgam: a status report.

Burnishing of amalgam: a status report.


Treatment of class III fractures in the hemophiliac patient: A case report.


The dentist and the speech pathologist.

The dentist and the speech pathologist.


Autotopic autotransplants--A review.

Autotopic autotransplants--A review.


Equilibrating the single crown.

Equilibrating the single crown.


Diagnosis and treatment of subgingival fractures.


Occlusal equilibration.

Occlusal equilibration.


Anterior crowns and their effect on periodontal health.


Dental radiology: standards of good practice and Tennessee radiation protection regulations.


Dumb salaries.

Dumb salaries.


Ringworm. Two-case report.

Ringworm. Two-case report.


Let's have flexible expansion of duties.


Expanded duties for auxiliaries.

Expanded duties for auxiliaries.


Editorial: An association of strangers?

Editorial: An association of strangers?


Basic electrosurgery in daily dental practice.


Let's proceed with caution on expansion.


Analysis of regrowth pattern of irradiated murine tumors.


Opening address. 48th Annual Conference of the New Zealand Veterinary Association.


The future of rural veterinary practice.


Respiratory diseases of beef cattle under intensified systems.


The poultry industry in New Zealand.

The poultry industry in New Zealand.


Pharmacological aspects of bunamidine dosing of dogs.


The efficiency of a mixture of haloxon and trichlorfon against strongyles and bots in horses.


Experimental Eperythrozoon ovis infection of sheep.


A possible deficiency of cell-mediated immunity in the opossum, Trichosurus vulpecula, in relation to tuberculosis.


Some observations on disease incidence among dairy cattle in North Taranaki.


A limited survey of gastro-intestinal helminths of dogs and cats.


Letter: Copper poisoning in sheep grazing in an orchard.


Letter: "Red gut" syndrome in lambs grazing lucerne.


Maxillary sinus carcinoma. Case report.

Maxillary sinus carcinoma. Case report.


Recognition of periodontal disease.

Recognition of periodontal disease.


A dental care program. Proposed to the Ontario Government by the Ontario Dental Association, July 19, 1973.


Editorial: Ontario denticare.

Editorial: Ontario denticare.


Periodontal therapy.

Periodontal therapy.


A conservative approach to a complex periodontal problem.


Radiation treatment of cervical node metastases.


The importance of a detailed drug history for the dentist.


Antigenicity of the capsular polysaccharide of Klebsiella rhinoscleromatis in mice.


Sixth Texas Symposium on relativistic astrophysics.


Pressure dynamics of endotracheal and tracheostomy cuffs. 1. Use of a tracheal model to evaluate performance.


Sex difference in gonadal maintenance in graded hypophysectomized rats.


Comparison of influenza virus hemagglutinin, neuraminidase and their antibody responses in infected patients.


One hundred cases of intussusception in children.


Crohn's disease located at proximal jejunum--case report.


Editorial: Walter Reed Army Medical Center.


Hyperfunctioning thyroid nodules that become "cold".


Adrenal insufficiency resulting from metastasis of non-functioning adrenocortical carcinoma.


Metastases in bone marrow and pancytopenia from carcinoma of the lung (report of a patient and review of the literature).


Dysphagia lusoria: a forgotten entity?

Dysphagia lusoria: a forgotten entity?


99m Tc sodium pertechnetate scanning of the abdomen, a valuable tool for detection of Meckel's diverticulum.


Cardiorespiratory complications of intravenous drug abuse.


Ineffective erythropoiesis.

Ineffective erythropoiesis.


Neurological, neuropsychological and behavioral aspects of Gilles de la Tourette's syndrome: a case.


Stimulation of macrophage phagocytosis by clofazimine.


Premature eruption in the primary dentition--a clinical and radiological study.


The retention of parapulpal pins used in amalgam fillings.


Wear and hygiene status of toothbrushes in relation to some social background factors.


A psychological aspect of dentistry.

A psychological aspect of dentistry.


Angiography of the hand. Clinical and postmortem investigations.


Letter: Temporomandibular joint function and its effect on centric relation.


Inhibitors of the bone-marrow colony formation in sera of patients with leukemia.


Letter: Words "most retruded" in describing centric relation.


Letter: Definition of centric occlusion is confusing.


Letter: Jaw movements in young adult men during speech.


Letter: A comparison of articulator mountings made with centric relation and myocentric position records.


Physiologic mandibular resting posture.

Physiologic mandibular resting posture.


Influence of cavity design, heat treatment, and cementation on MOD gold inlays. II. Resistance to removal under tensile stress and its relationship to the cavity surface area.


Construction of a mouthpiece for studying the effects of smoking in dogs.


Milling machine for coloring heat-vulcanizing silicone materials in maxillofacial prosthetics.


Construction of a denture with hollow obturator, lid, and soft acrylic lining.


Coronary artery disease. Correlation of laboratory and clinical manifestations.


"Know-how" in aids for handicapped.

"Know-how" in aids for handicapped.


Changing of atmospheric environment to improve mental and behavioral function. Applications in treatment of senescence.


Unmanned Martian roving vehicle. Inspires stair-climbing wheelchair.


Hepatic and cardiac protein synthesis. Alcohol vs. nutrition.


Protective effect of muscle mass. Antagonism between body fat and muscles.


Is there an association between narcotic addiction and false-positive VDRL test results?


What is the dose of penicillin to be used as a skin test for "penicillin allergy"?


Are there any reports of organic brain syndrome resulting from concomitant use of phenothiazines and anti-Parkinsonian agents?


Unusual vasculitis.

Unusual vasculitis.


Gas-containing gallstones.

Gas-containing gallstones.


Trash in, trash out.

Trash in, trash out.


Provision for medical care needs.

Provision for medical care needs.


Sex education in schools.

Sex education in schools.


Letter: Coloscopy--a rebuttal.

Letter: Coloscopy--a rebuttal.


Dibromomannitol therapy of chronic myelogenous leukemia during pregnancy.


Proceedings: An appraisal of cytogenetics in leukemia, including a correlation with the evolution and prognosis of acute leukemia.


Proceedings: Infection problems in childhood cancer.


Proceedings: The chronic leukemias: current therapeutic concepts.


Prolonged administration of ethanol to young, healthy volunteers: effects on biochemical, morphological and neurophysiological parameters.


The use of isotope exchange reactions for the study of oxygen transfer from H2O and from CO2 to metals and oxides.


Investigation of oxide-type oxidation catalysts by reactions of oxygen isotopic exchange.


The use of tracers in studying the mechanism of heterogeneous catalysis by microwave spectroscopic techniques.


Tracer study on intermediates in some metal-catalyzed hydrocarbon reactions.


Velocity ratio characterization of complex reactions.


Elucidation of dehydrocyclization mechanisms with 14C-tracers.


An appreciation of the stoichiometric number method from the viewpoint of quantum statistical mechanics.


The use of tracers to study heterogeneous catalysis. Introductory remarks.


Reaction mechanisms.

Reaction mechanisms.


Electrochemistry reaction rates.

Electrochemistry reaction rates.


Recent applications of the kinetic isotope method.


The kinetics of transfer of labeled atoms by reaction.


Theory of reaction rates as based on the stoichiometric number concept.


Exchange reactions on oxide catalysts.

Exchange reactions on oxide catalysts.


The importance of hereditary factors in dental surgery.


Interstitial myofibrositis: serum and muscle enzymes and lactate dehydrogenase-isoenzymes.


Oral medicine for the dental practitioner. 5. Oral lesions in diseases of the skin.


An unusual accident in the dental surgery.


Arctic dentistry.

Arctic dentistry.


Solubility-reducing agents in honey and partly-refined crystalline sugar.


Dicentric Ph1 chromosome.

Dicentric Ph1 chromosome.


Carcinogenicity of 5-nitrofurans, 5-nitroimidazoles, 4-nitrobenzenes, and related compounds.


The relationship between red cell acetylcholinesterase activity and Ii antigenicity in leukaemia.


Hypergranular acute promyelocytic leukaemia with intravascular coagulation.


Ultrastructural studies on the acute leukemic lymphoblast.


Some immunological properties of lymphoid cells from patients with acute lymphatic leukaemia (ALL).


Laboratory investigations on caries prevention.


Public health and individual measures in the prevention of dental caries.


Guidelines for dental nutrition counselling.


Dietary sugars and sugar substitutes.

Dietary sugars and sugar substitutes.


Prevention of malocclusion and dentofacial anomalies.


Review of dental health activities of the World Health Organization in the region of the Americas.


In vivo ventricular responses to mechanical afterloading in the chordotomized rat.


Brain mechanisms and feeding behavior in the pigeon (Columba livia). II. Analysis of feeding behavior deficits after lesions of quinto-frontal structures.


Erythroid histones in chronic erythremic myelosis.


The effect of vagal stimulation on the myocardium in the cat.


Evidence for the clonal origin of chronic myeloid leukemia from a sex chromosome mosaic: clinical, cytogenetic, and marrow culture studies.


Cell-mediated immunity in acute nonlymphocytic leukemia: relationship to host factors, therapy, and prognosis.


Identification and mounting of radiographs.


Preparing for office emergencies.

Preparing for office emergencies.


The dental assistant in complete denture prosthetics.


Dental auxiliary identity crisis.

Dental auxiliary identity crisis.


Rules and regulations for certification renewal.


The advice givers.

The advice givers.


The questions patients ask.

The questions patients ask.


The computer age in dentistry: 'It's already here'.


When and how to use composites to salvage severely damaged teeth.


Scurvy: a case report.

Scurvy: a case report.


Composite build-up technic to restore a molar crown.


Puzzle: which treatment plan?

Puzzle: which treatment plan?


Making 'expanded functions' work--and pay.


Editorial: Reaching patients: Psychology plus common sense.


Accentuate the positive for best results.


(de Vere-Green C),+DEVEREAAGREEN C:Dr. deVere-Green receives Fauchard Academy award in ceremony at London Embassy.


A design for prevention, expansion.

A design for prevention, expansion.


Improved diabetes screening technic for the dental office.


Addition of stannous fluoride to orthodontic cement.


Sports and the dentist.

Sports and the dentist.


Missing teeth and dentures--killers of 2,500 annually. The dentists role in the prevention and treatment of food asphyxiation.


Sleep-induced apnea. 1. A respiratory and autonomic dysfunction syndrome following bilateral percutaneous cervical cordotomy.


Table of allowance.

Table of allowance.


Internship and residency programs.

Internship and residency programs.


Body image in orthodontics.

Body image in orthodontics.


Dental care insurance.

Dental care insurance.


Aids for TMJ treatment.

Aids for TMJ treatment.


N2, a perspective.

N2, a perspective.


Acute endodontic flare-ups.

Acute endodontic flare-ups.


Compound composite odontoma.

Compound composite odontoma.


Clinical evaluation of Nuva-Fil.

Clinical evaluation of Nuva-Fil.


Teaching preventitive concepts.

Teaching preventitive concepts.


New Jersey's pending HMO bill.

New Jersey's pending HMO bill.


Study of replantation of permanent teeth.


Reconstruction by maxillofacial prosthesis following extensive cancer surgery.


The rubber impression for pin restorations.


Dental insurance in Ontario. 3. Simplify your claims submission.


Editorial: Peer review.

Editorial: Peer review.


Clinical medicine as applied to dental practice.


Water fluoridation: deliberate pollution?


What happens in bankruptcy.

What happens in bankruptcy.


Editorial: Consumer education is preventive dentistry.


Fluoride supplements for prophylaxis of caries.


A developmental theory of speech act production.


Atherosclerotic heart disease and the environment.


A study on in vitro isolation of feline panleukopaenia virus.


Localization of horse radish peroxidase in mouse and guinea pig peritoneal macrophages after uptake in vivo and in vitro. An electron microscope study.


A brief outline of radiography.

A brief outline of radiography.


Pedunculated lesions. I. (Papillary type).


Federal Court says: Dental Board protecting people of Florida.


FLADPAC, what is it?

FLADPAC, what is it?


A Bolivian experience.

A Bolivian experience.


Clinical use of some dental materials.

Clinical use of some dental materials.


The influence of length of topical application of stannous flouride upon enamel fluoride content.


Gingival lesions in histoplasmosis.

Gingival lesions in histoplasmosis.


A representative of the 6th trustee district evaluates the ADA.


Dental malpractice.

Dental malpractice.


Conservative approach in a case of an ameloblastoma.


Local anaesthetic sensitivity. Case report.


Dentistry in public health.

Dentistry in public health.


Maxillofacial prosthetics: its relationship to general dentistry.


Ultrastructure of nerves in the dentinal-pulp border zone after sensory and autonomic nerve transection in the cat.


Comparative effectiveness of some commonly prescribed drugs for the relief of post-surgical discomfort.


Influence of vasodilator substances on pulpal blood flow in the cat.


Growth in height of autotransplanted nasal septum in the rat. Its correlation to increase in height of the upper face.


Studies on the permeability of human oral mucosa. VI. The mucosal transport of water, sodium and potassium under varying osmotic pressure.


A system to classify the need for periodontal treatment.


The human spheno-occipital synchondrosis. II. A histological and microradiographic study of its growth.


Oxygen administration during artifical ventilation with pressure cycled respirators.


Lymphoepithelial (branchial) cyst of the parotid gland.


Dermoid, epidermoid, and teratomatous cysts of the tongue and the floor of the mouth.


Modified palatal flap technique for closure of oroantral fistulas.


Case 5, Part 1.

Case 5, Part 1.


Epidermoid cyst of the tongue: report of case.


Traumatic pseudocyst of the parotid gland.


Osteosarcoma of the jaws: report of case and review of the literature.


Zygomatic complex fracture with an avulsed tooth causing malocclusion: report of case.


Skeletal differences in identical twins.


Nevoid basal cell carcinoma syndrome in Negroes: report of five cases.


Clinical applications of central venous pressure.


Transpositional genioplasty.

Transpositional genioplasty.


Arteriovenous fistula of the anterior facial vessels: review of the literature and report of case.


Bacteroides infections in oral surgery.

Bacteroides infections in oral surgery.


Gas chromatographic measurement of perphenazine in whole blood.


Clinical-pharmacological aspects of measuring perphenazine in human blood.


General clinical aspects of depot neuroleptics and some experiences with depot neuroleptics.


Psychiatric consultation in the local milieu, with an evaluation of the place of depot neuroleptics in this work.


Comparison of conventional neuroleptic therapy with depot neuroleptics. An attempt at economic evaluation.


Some pharmacological aspects of depot neuroleptics.


Preformed polycarbonate crowns for the restoration of anterior teeth.


Iontophoresis for surface local anesthesia.


Blacks in dentistry.

Blacks in dentistry.


1974 to be major year for growth of Delta Plan enrollment. Delta Dental Plans Association.


Marginal failure of amalgam in deciduous teeth: a two-year report.


An overfilled underfilled root canal: report of case.


Certification program for dental materials: List of Certified Dental Materials revised to January 1, 1974. Council on Dental Materials and Devices.


Accredited dental schools. Council on Dental Education.


List of Classified Dental Materials and Devices revised to January 1, 1974. Council on Dental Materials and Devices.


Continuing education. Course listing for January 1974 through May 1974. Council on Dental Education.


Editorial: The now and future image.

Editorial: The now and future image.


General statement of advertising and exhibiting policy.


Letter: Transition in dentistry.

Letter: Transition in dentistry.


Letter: New Zealand dental nurses.

Letter: New Zealand dental nurses.


Letter: Urge licensing changes.

Letter: Urge licensing changes.


Letter: Comments on hypothesis of etiology of recurrent severe facial emphysema in a submariner.


Guidelines on disposition of practices, estate planning, and funeral arrangements with estate planning data worksheets.


Review of 1973 news.

Review of 1973 news.


Dental prepayment, assuaging the growing pains. Council on Dental Care Programs.


Position statement of the American Dental Association on dental licensure.


Letter: Three "reciprocal" approaches.

Letter: Three "reciprocal" approaches.


Letter: New Zealand summary.

Letter: New Zealand summary.


Letter: Simple claim form.

Letter: Simple claim form.


A new era begins in meeting the needs of education, research, and dental health.


New hope in meeting the needs of education.


Innovative research and relevant targets.


Majority favor honor system at Buffalo.

Majority favor honor system at Buffalo.


Solving the problems in dental health service.


The professional liability committee--first line of defense in malpractice claims.


Oral involvement in neuroblastoma.

Oral involvement in neuroblastoma.


Immediate overdenture.

Immediate overdenture.


Physical and mechanical properties of zinc polyacrylate dental cements.


Technical factors in dental radiography in Hiroshima and Nagasaki.


Pit and fissure sealants. Council on Dental Materials and Devices.


Effect of a pumice prophylaxis on fluoride uptake in tooth enamel.


Recommendations in mercury hygiene, February 1974. Council on Dental Materials and Devices, American Dental Association.


Current evaluation of dental endosseous implants. Council on Dental Materials and Devices, Council on Dental Research.


Stimulation of intestinal secretion by polypeptide hormones.


Leukemic mitochondria. I. Acute myeloblastic leukemia. Quantitative and qualitative electron microscopic studies were performed on the mitochondria of leukemic myeloblasts in 3 patients with myeloblastic leukemia and in 3 patients with myelomonoblastic leukemia. In addition, to confirm the presence of virus-like particles within mitochondria and better understand the interaction between the virus and mitochondrion, a rat embryo tissue culture infected with MSV-MLV (Moloney sarcoma virus-Moloney leukemia virus) was selected for detailed electron microscopic examination. Significant quantitative differences between normal and leukemic human mitochondria were not observed. However, qualitative abnormalities were found in the human leukemic mitochondria and in the tissue culture material. These abnormalities included variable forms of the leukemic mitochondria (twisted, tear-drop and irregular shapes), fewer cristae, disrupted mitochondria with virus-like particles, smaller granules in greater abundance, mitochondrial DNA, and contact between the mitochondrion and the nucleus. The tissue culture material revealed similar changes, but showed more virus particles which were located outside the cells, in intracytoplasmic sacs and within the mitochondria. In addition two striking features were observed in the tissue culture material not seen in the human material: a) Budding from the outer mitochondrial membrane into the mitochondrial matrix and b) virus particles attached to the cristae. Since mitochondria are important organelles in the glycolytic-oxidative phosphorylation pathways, perhaps all of us engaged in cancer research should take a closer look at the Warburg effect and carefully consider extranuclear factors operating in oncogenesis.


Psychoanalytical thoughts on the concept of national character.


Victimology and the needs of contemporary society.


A follow-up study of the Norwegian concentration camp survivors' mortality and morbidity.


Types and treatment of adolescent drug abusers in Israel.


Cancer mortality in Chang-Hua county.

Cancer mortality in Chang-Hua county.


Suicide among minors in Israel.

Suicide among minors in Israel.


In vitro inactivation of gonadotrophins by psidium root extract.


Immunodiagnosis of some parasitic diseases of the respiratory system.


Studies on acute drug poisoning.

Studies on acute drug poisoning.


A study on family planning knowledge and attitudes of twenty-year old single males in Taiwan.


Study on the binding of aflatoxin B1 to cellular components. I. Binding of aflatoxin B1 to albumin in vitro.


Studies on the effect of riboflavin tetrabutyrate on the atherosclerosis induced by cholesterol feeding in rabbits. I. Effect of riboflavin tetrabutyrate on serum and hepatic lipids.


Teratogenic effects of sulfadimethoxypyrimidines and sulfadimethylpyrimidines in chick embryos.


Two cases of unusual nasopharyngeal polyp.


Effects of prolonged feeding of D-xylose on rats.


Studies on the effect of riboflavin tetrabutyrate on the atherosclerosis induced by cholesterol feeding in rabbits. II. Effect of riboflavin tetrabutyrate on the formation of atherosclerosis.


Alpha-bungarotoxin and the acetylcholine receptors in the motor end-plate.


Immunoassay of insulin in the aqueous humour of diabetics and non-diabetics with or without cataract.


Preliminary clinical trial of 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1 nitrosourea (NSC-95411) (MeCCNU) in human neoplasms.


Acute renal effects of high doses of furosemide administered intravenously in patients with advanced chronic renal insufficiency.


L-asparaginase treatment in acute leukemia of childhood.


Particle configuration of prophylaxis pastes as observed by scanning electron microscopy.


Rheumatoid arthritis of the temporomandibular joint: case report.


Relationship of occlusion and periodontal disease. 8. Relationship of crowding and spacing to periodontal destruction and gingival inflammation.


The microvasculature of the rabbit gingiva as affected by progesterone: an ultrastructural study.


Genetics in medical practice of 1970s. Practical applications.


Medullary sponge kidney and congenital total hemihypertrophy.


Plasma and urine levels of methadone. Comparison following four medication forms used in chronic maintenance treatment.


"Salting out" an abdominal pregnancy.

"Salting out" an abdominal pregnancy.


Sirenomelia.

Sirenomelia.


Transjugular removal of catheter embolus.


Electrocardiograms of the month: heart block.


Infection due to Pseudomonas stutzeri.

Infection due to Pseudomonas stutzeri.


Middle-life crisis of the physician.

Middle-life crisis of the physician.


Letter: Recertification.

Letter: Recertification.


Letter: Clindamycin and lincomycin.

Letter: Clindamycin and lincomycin.


Motility disturbances of the esophagus: a working classification with remarks on surgical management.


America's no. 1 crisis.

America's no. 1 crisis.


The Southern New England Cancer Group.

The Southern New England Cancer Group.


Gaucher's disease. (Case report).

Gaucher's disease. (Case report).


Medical compassion.

Medical compassion.


Effect of ultraviolet light on the skin.


Occurrence and possible role of Moraxella species in pigs.


Studies on Stachybotrys alternans. I. Isolation of toxicogenic strains from finnish grains and feeds.


Cytogenetical findings in children born to carriers of hepatitis-associated antigen.


Study of Australia-SH antigen in diluted uman serum by electron microscopy.


Analysis of the variation in lymphocyte response to PHA in normal subjects.


Reversal in stereo discrimination by contrast reversal.


Studies on adenovirus receptors on red cells.


Changes in central and peripheral corneal thickness with menstrual cycle.


The effect of lightness contrast, tachistoscopic duration and fundus pigmentation on the magnitude of the Mueller-Lyer illusion.


Pupil-retina interaction, an analog eye response model.


Diffusion properties of hydrophilic materials.


The relationship between ocular motilities and batting average in little leaguers.


Preventive measures in oral cancer control.


Drug-protein binding in the newborn infant.


Influence of disease on binding of drugs to plasma proteins.


The alteration of plasma proteins in uremia as reflected in the ability to bind diphenylhydantoin.


Circular dichroism studies of Y protein (ligandin), a major organic anion binding protein in liver, kidney, and small intestine.


Pharmacokinetic consequences of plasma protein binding of drugs.


Influence of binding on the toxicity of bilirubin.


A new approach to the determination of protein-bound bilirubin displacement and its applications.


Influence of free fatty acid concentration on drug binding to plasma albumin.


Drug-protein binding: discussion paper: results with propanolol.


The binding of sodium warfarin to plasma albumin and its displacement by phenylbutazone.


Increasing excretion of urate with displacing agents in man.


Influence of intravenous injection rate on protein binding and vascular activity of diazoxide.


The influence of acetylsalicyclic acid on the binding of acetrizoate to human albumin.


Drug-protein binding.

Drug-protein binding.


Summary and future directions for drug-protein binding.


Computer analysis of drug-protein binding data.


Effect of protein binding on the distribution of 5,5-diphenylhydantoin between plasma and red cells.


Dynamic response characteristics of the human vertebral column. An experimental study on human autopsy specimens.


Operative elimination of partial premature epiphyseal closure. An experimental study.


Identification of 6-methylmercaptopurine ribonucleoside 5'-diphosphate and 5'-triphosphate as metabolites of 6-mercaptopurine in man.


Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.


Temporary suppression of Streptococcus mutans in humans through topical application of vancomycin.


Effect of a topically applied 3 percent vancomycin gel on Streptococcus mutans on different tooth surfaces.


Adsorption of salivary proteins by hydroxyapatite: effects of phosphate ions and interdependence of the effects of phosphate and hydrogen ions.


Influence of thiamine on fluoride retention in the rat.


Potential for keratinization of the sulcular epithelium in the dog.


In situ localization of proline in oral bacteria and on lingual epithelium.


Effect of maternal fluoride intake on preweaning bone fluoride concentrations in mice.


Fluoride uptake in rats given nonacidulated and acidulated tea.


Inhibition of masticatory muscle activity after stimulation.


Effect of drinking water with and without fluoride on the mineralization of the rat incisor.


Regression equation for lower dentures.

Regression equation for lower dentures.


Breaking strength of fluoride-treated dentin.


Chemical nature of cementing matrixes of cements formed from zinc oxide and 2-ethoxybenzoic acid-eugenol liquids.


Variations in the crystalline components of human dental calculus. I. Crystallographic and spectroscopic methods of analysis.


Separation of sulcular gingiva into epithelial and connective tissue portions.


Stabilization of parotid flow rate in the dog.


Local clearance of 131I-4-iodoantipyrine in oral mucosa and subcutaneous tissue of cats.


Tensile bond strength between fissure sealants and enamel.


Hemodynamic deformation of alveolar socket walls.


Electron microprobe investigations of stannous fluoride reactions with enamel surfaces.


General surgical waiting lists and the management of varicose veins.


The modern treatment of varicose vein disease.


High incidence of tumours of testis in New Zealanders, both European and Maori.


General practice registrar training scheme in Southland 1972.


Scanning electron microscope study of stannous fluoride-treated enamel surfaces.


Comparison of in vitro fluoride uptake by human and bovine enamel from acidulated phosphate-fluoride solutions.


Fluoride secretion in rat bile.

Fluoride secretion in rat bile.


Gas chromatographic experiments on tooth carbonates.


Aging in human attached gingival epithelium.


Drugs and genes.

Drugs and genes.


Relationship of submerged deciduous molars to root resorption and development of permanent successors.


Syndrome of anaemia, thrombocytopenia and subnormal granulocyte function in elderly patients.


Action of Streptococcus mutans on dental enamel pretreated with stannous fluoride.


A new dental superalloy system. V. Embrittling phase transformations.


Studies of porcelain jacket crowns by means of two-dimensional photoelastic experiments.


Small specimen strain measurement by moiré fringes.


Treatment of non-vital permanent incisors with calcium hydroxide. II. Effect on external root resorption in luxated teeth compared with effect of root filling with guttapucha. A follow-up.


A comparative study of clinical and roentgenological recording of proximal caries in primary molars of preschool children.


Perturbation of cell cycle of human leukaemic myeloblasts in vivo by cytosine arabinoside.


The effect of the calcium saccharose phosphate preparation Anticay on dental caries in the golden hamster.


The mylohyoid bridge: an anomalous derivative of Meckel's cartilage.


A method of isorhodopsin analysis and the photoreversal of rhodopsin intermediates.


Performance of partially sighted with Randsight I equipped with an X-Y Platform.


Efficacy of chemical asepticizing system for soft contact lenses.


A pneumatic applanation tonometer-a clinical study.


Comparative studies: visual acuity with spectacles and flexible lenses, ophthalmometer readings with and without flexible lenses.


A low-vision patient's expectations-a partial case report.


Prescribing contact lens solutions.

Prescribing contact lens solutions.


Effectiveness of non-strabismus optometric vision training in a private practice.


The mental health crisis in ophthalmology.


Communication: the profession and the public.


The Canadian Dental Association Group Life Program.


Help your patients "kick the sweet snack habit".


Federal income tax returns by dentists.

Federal income tax returns by dentists.


Sequential reproduction of intra-oral radiographs.


Particle concentrations in patient rooms with various types of ventilation. Particle concentration in patient rooms at various ventilation rates and with differing methods of air supply has been investigated experimentally in a specially built test room. The size of the test room corresponded to an ordinary bedroom for two patients. Air was supplied isothermally to this test room, either through induction units or through a perforated ceiling, and the number of air changes per hour varied from 1 to 16. When the air was supplied by means of induction units, tests with different airflow patterns in the room were also carried out. The principle of the measurements was to estimate the decrease in particle concentration at certain points when the initial concentration was uniform all over the room and no generation took place during the measuring period. Talc powder was used as test dust, and the particle concentration was measured at up to six points in the room with a particle counter.The measurements show that air-supply method and airflow pattern affect the particle concentration, but that the differences in concentration are small compared with those obtained when the ventilation rate is varied. However, the results should not be directly applied to systems with particle generation.


Common colds in Antarctica.

Common colds in Antarctica.


An outbreak of common colds at an Antarctic base after seventeen weeks of complete isolation. Six of 12 men wintering at an isolated Antarctic base sequentially developed symptoms and signs of a common cold after 17 weeks of complete isolation. Examination of specimens taken from the men in relation to the outbreak has not revealed a causative agent.


Two community outbreaks of human infection with Yersinia enterocolitica. Two outbreaks of human infection with Yersinia enterocolitica in Shizuoka, Japan are described. This is the first report of community outbreaks of infection with this organism in Japan, and possibly in the world. All the strains isolated in each outbreak belonged to O antigen group 3, biotype 4, of the species. Despite much effort, the source and mode of spread of the infection were not established.


Isolation, ultrastructure and antigenicity of Mycoplasma gallisepticum membranes. The cell membrane of Mycoplasma gallisepticum was isolated by lysing the cells with digitonin. Chemical and density-gradient analyses and electron microscopy showed the isolated membranes to be relatively free of cytoplasmic contaminants. The density of the membranes exceeded that of other mycoplasma membranes, indicating a higher protein content. Small vesicular extensions seen in the sectioned membranes were interpreted as empty blebs.The isolated membranes, but not the cytoplasmic fraction, elicited in chickens the production of growth-inhibiting, agglutinating and haemagglutination-inhibition antibodies to M. gallisepticum in titres resembling those obtained by injection of whole cells. The peak of the serological response varied with the serological test employed. The rapid slide-agglutination test became positive as early as 3 days after the first injection of only 50 mug. of membrane protein. The haemagglutination-inhibition antibody titre reached its peak at about 10 days after the first injection, while that of the growth-inhibiting antibodies was reached only at about 25 days. The addition of adjuvant to the membrane antigen did not improve the production of the growth-inhibiting antibodies in chickens, but it produced some improvement in rabbits. Our results support the thesis that the chief immunogens of M. gallisepticum reside in the cell membrane of this organism.


A note on the hygiene of meat mincing machines. Two mincing machines were cleaned by different methods, i.e. (a) a detergent/sterilizer method and (b) scrubbing parts in boiling (98.8 degrees C.) water. Initial results indicated that, on reassembly, post-treatment contamination took place. Efforts to clean each machine as consisting of two distinct parts, (a) the casing and (b) removable parts, were more satisfactory. Four other mincers which could be completely dis-assembled were satisfactorily cleaned, but only in terms of percentage organisms surviving and not in terms of actual numbers surviving.


Skin tests with influenza virus.

Skin tests with influenza virus. Skin reactions have been produced in normal subjects by the injection of highly purified influenza A and B viruses. The reactions reached a maximum at 24-48 hr. and the histological pattern was compatible with a delayed hypersensitivity reaction. There was no close relation between skin test results and circulating antibodies. Twenty-seven subjects were challenged intranasally with attenuated influenza A (H3N2): 5 of 14 skin-test-negative subjects were infected, but none of 13 skin-test-positive subjects.


Dispersal and transfer of Staphylococcus aureus in an isolation ward for burned patients. The dispersal of Staphylococcus aureus from burned patients, the relation between nasal carriage by the staff and exposure to airborne Staph. aureus, and the transfer of Staph. aureus-carrying particles within the ward have been studied. The dispersal of Staph. aureus from burned patients was correlated to the size of the burn wound. The median values varied from 21 c.f.u./m.(2)/hr. for patients with small burns to 453 c.f.u./m.(2)/hr. for extensively burned patients. The size of the dispersed particles appeared to be smaller than that usually found in hospital wards. Carriage of nasal strains by the staff was correlated to the air counts; the number of patient sources did not seem to be of great importance. The transfer of Staph. aureus within the ward was at least 6 to 20 times that which would have been expected if transfer was due to air movement only.


Transfer of Staphylococcus aureus via nurses' uniforms. The contamination of gowns and uniforms worn in a burns unit and the transfer of patient's staphylococci by means of nurses' uniforms was investigated. The median values of staphylococci found on gowns and jackets worn during a routine nursing procedure were 3.0 x 10(4) and 1.4 x 10(3) respectively. From the results of model nursing experiments it appeared as if the fraction of staphylococci transferred from a patient's room to the air in a receiving room was 4 to 10 times less when protective gowns were worn than when no gowns were worn. The corresponding transfer directly to the model ;patient' was 100 times less. The protection afforded by a gown seemed mainly to be due to protection against contamination of the uniform worn underneath when nursing a burned patient. The discrepancy between the transfer of an airborne particle tracer and Staph. aureus-carrying particles earlier found in the ward could be explained by the dispersal of Staph. aureus from nurses' clothing.


Cystic dilatation of the common bile duct in adults.


A study of immunity to rubella in villages in the Fiji islands using the haemagglutination inhibition test. In the villages of Fiji, apart from Viti Levu, rubella is a disease occurring solely in widely spaced epidemics. Some villages may not be infected for over 20 years and will then contain substantial numbers of susceptible women of child-bearing age.Evidence is produced that haemagglutination-inhibiting (H.I.) antibody to rubella is very long lasting in Fijians. The infectivity of the virus is discussed and it is suggested that, on the average, 50% of susceptibles are infected in a Fijian village during a rubella epidemic, but there are large variations.


Membrane lung support in acute respiratory insufficiency.


Complications of therapeutic abortion utilizing intra-amniotic hypertonic saline.


Hypohidrotic ectodermal dysplasia; an unusual presentation.


Economic aspects of drug over use.

Economic aspects of drug over use.


Outgoing President's Address: Success and prestige of our dental society.


President's Address: 'The State of the District'.


A recent graduate--the future?

A recent graduate--the future?


The endodontic stabilizer and the patient's bill of rights.


Thumbsucking. Dental and psychological aspects.


Editorial: Dental health education--whose role?


Total dental care for the adolescent.

Total dental care for the adolescent.


Acute lymphocytic leukemia in childhood.


The preleukemic syndrome.

The preleukemic syndrome.


Editorial: The problem-oriented record in psychiatry.


Editorial: Hypertension and depression and their treatment.


Editorial: Women university students and careers.


Family therapy and its social implications.


A study of aetiological factors at critical periods of development in autistic children.


Immigration and mental disease.

Immigration and mental disease.


Levels of psychotherapy: a study of intimacy.


The melancholy hero--a like in the evolution of medical psychology.


Operant conditioning of emotional responsiveness as a prerequisite for behavioural analysis: a case study of an adolescent school phobic.


The effect of token reinforcement on verbal participation in a social activity with long stay psychiatric patients.


The patient's dilemma: who is an 'authority'?


Management of group homes.

Management of group homes.


Religion and insanity--folie partagee--folie a trois.


Premature ejaculation treated by the dual sex team method of Masters and Johnson.


Two features occasionally associated with intravenous drug users: a note.


Adult acute leukaemia--a suitable case for treatment?


Mandibular asymmetry associated with perimandibular hemangiomas.


Further findings concerning the occurrence of clefts in twins.


The nuclear DNA-content of turnover cells in the oral cavity.


Congenital lateral fistula of upper lip. A case report.


Repair of the mandibular nerve by means of autologous nerve grafting after resection of the lower jaw.


Osteosynthesis with miniaturized screwed plates in maxillo-facial surgery.


Tooth vitality after alveolar segmental osteotomy.


Correction of noses associated with clefts of lip and palate.


A contribution to the problem of velopharyngeal incompetence. A preliminary report.


Secular changes in tooth size in Swedish men.


Changes in the foramen magnum axis during human foetal life.


A histochemical study of arylaminopeptidases and alkaline phosphatases in sound and carious human teeth.


Reaction of the human dental pulp to silver amalgam restorations. The effect of insertion of amalgam of high plasticity in deep cavities.


Normal histology and the effect of acute mechanical stress on the esophagus epithelium in the guinea pig.


Gastrointestinal problems in the old. I.


Biomedical science in the future.

Biomedical science in the future.


Research policy and organization in dental research.


Morphometric analysis of occlusal fissures in human premolars.


Retention of a fissure sealant with caries reduction in Finnish children after six months.


Fluoride release from varnish-coated silicates and from cavity liners and fissure sealants.


Dissolution of enamel.

Dissolution of enamel.


Reduction of enamel solubility and plaque development with chlorhexidine-fluoride solutions.


Plaque accumulation on different dental filling materials.


Histoquantitation of ground sections of human mandibles.


Incidence of stained tooth surfaces in students using chlorhexidine-containing dentifrices.


Comparison of radiographic and clinical signs of early periodontal disease.


The application of twin methods in orthodontic research.


In vivo and in vitro studies on a new peroxide-containing toothpaste.


A zinc-copper phase in dental silver amalgam alloy.


Chronic myelogenous leukaemia. The juvenile and adult types. Report of two cases.


New hopes in acute lymphoblastic leukemia.


Paroxysmal nocturnal haemoglobinuria and chronic myeloid leukaemia in the same patient.


Letter: The relationship of erosion and attrition in extensive tooth tissue loss.


Gupta SK:A defect of the orthopantomograph. Simulated fracture of the mandible.


Letter: Comments on the General Dental Council's recommendation concerning the dental curriculum.


Gentle dental men.

Gentle dental men.


The effects of Ka and Hb genotypes on blood electrolytes and haemoglobin in sheep.


Mutation and population size.

Mutation and population size.


Cross-overs, sperm redundancy and their close association.


Endoscopy of the maxillary sinus.

Endoscopy of the maxillary sinus.


Celesnik procedure in the surgical treatment of bilateral complete clefts.


Bitemporal suspension as an alternative method of craniofacial suspension.


Recurrence of oral cancer in patients with radio-osteomyelitis of the jaws.


The inner osseous architecture and the sagittal splitting of the ascending ramus of the mandible.


Variation of fibrous dysplasia in the jaws.


The uptake and release of antibiotics by lyophilized bone.


Similar hemodynamic and metabolic responses to ketamine and glucagon.


Deficiency of antithrombin 3 activity associated with hereditary thrombosis tendency.


Three-dimensional photoelastic stress analysis of maxillary complete dentures.


A comparative study of sagittal and lateral condylar paths in different articulators.


"Myo-Monitor centric": an evaluation.

"Myo-Monitor centric": an evaluation.


Color matching in dentistry. 3. Color control.


Incisal guidance of natural teeth in adults.


Comparison of methods used in finishing composite resin--a scanning electron microscope study.


Management of coronal fractures of permanent posterior teeth.


Crown retention. I. Stress analysis of symmetric restorations.


Root surface area measured by the benzene adsorption method.


Pin retention with carboxylate cement.

Pin retention with carboxylate cement.


Letter: Importance of a stable maxillomandibular relation.


The construction and implantation of a silicone rubber cranial prosthesis.


Prophylaxis and its application to the patient's first visit.


Mercury hazards in dental practice assessment and control by activation analysis.


Lesions of the jawbones.

Lesions of the jawbones.


Nug. Some uncommon ideas about a common disease.


The acute apical abscess.

The acute apical abscess.


First-year gingivitis hunt.

First-year gingivitis hunt.


Part III of a three-part self study course in dental radiography for dental assistants. 3. Radiographic technique for periafical films.


Expanded duty assistants.

Expanded duty assistants.


Allergy tests.

Allergy tests.


Curriculum for learning to cope with "special patients" in the dental office.


The role of the DA in endodontics.

The role of the DA in endodontics.


The cardiorespiratory effects of epinephrine in local anesthetics for dentistry.


A patient recall system.

A patient recall system.


Mercury in the dental office.

Mercury in the dental office.


The male role in dental assisting.

The male role in dental assisting.


The Panksey story: New inspiration for the dentist.


Corporate practice...don't get caught in a tax trap.


Your treatment schedule: blueprint to a healthier practice.


How to choose an investment advisor. Part 2.


Where the I.R.S. would rather fight than switch.


What's the dif on your tax return?

What's the dif on your tax return?


How average are you?

How average are you?


The good news about the bad news.

The good news about the bad news.


Tax savings begin at home.

Tax savings begin at home.


How to handle a hobby horse.

How to handle a hobby horse.


Tax-free annuity? Anyone?

Tax-free annuity? Anyone?


How long to hang on to those tax records?


Documenting your casualty loss deduction.


Dental technician training in colleges and faculties of technology and further education in the U.K.--a survey.


The Epitome Dental Laboratory.

The Epitome Dental Laboratory.


Laboratory prices.

Laboratory prices.


Some atypical cases.

Some atypical cases.


Tissue conditioning materials in general dentistry.


Simple spring winder.

Simple spring winder.


Alcohol contamination of local anesthetic cartridges.


Simplified dental floss threader.

Simplified dental floss threader.


Sale of an orthodontic practice. Part II.


The periodontal examination. A review and reminder.


Pulpotomies in vital and non-vital permanent teeth.


The use of the Dentometer to increase banding efficiency.


Proposed continuing education requirements for relicensure.


Orthodontics in the Republic of South Africa.


Some more atypical cases.

Some more atypical cases.


Viral hepatitis cases increase.

Viral hepatitis cases increase.


Quaternary ammonia compounds: should they be used for disinfection in the dental office?


Legislating education in dentistry.

Legislating education in dentistry.


The Prepaid Health Plans---alive and well.


The effects of trichloroacetic acid on the hard and soft tissues of the oral cavity.


Peer review made easy.

Peer review made easy.


The dilemma of impacted teeth.

The dilemma of impacted teeth.


Dental manpower. Survey of the active members of the San Francisco Dental Society.


The Health Insurance Council's view of peer review.


Spherical alloy 1974: a status report.

Spherical alloy 1974: a status report.


Outline for hospital dentistry.

Outline for hospital dentistry.


San Leandro dentists establish clinic in Malawi.


Everything you ever wanted to know about the State Narcotics and Drug Control Section, but didn't know how to ask.


The hospitalized dental patient.

The hospitalized dental patient.


Unmet restorative treatment needs in a prison population.


Serial extraction.

Serial extraction.


Periodontal considerations in crownwork.


Dental students as dental hygienists.

Dental students as dental hygienists.


Dental education and practice in Greece.


Tax tips for the dentist.

Tax tips for the dentist.


Alveolar bone absorption due to a foreign body. Case report.


Shade taking made easy.

Shade taking made easy.


The concept of a profession. To whom do we profess?


Report of mercury contamination survey of dental offices in Maryland.


The synthesis of nucleic acids and proteins during the cell cycle.


Effects of chronic administration of adenosine on kidney and liver functions.


General practitioner requirements in orthodontic postgraduate courses.


The structure of calcospherites.

The structure of calcospherites.


Letter: High-dose bromsulphalein clearance test.


The survey on expanded duties for the dental hygienist.


Recurrent keratocysts in basal cell nevi syndrome.


Editorial: To be an editor and not to be one.


A plea for common sense in dentistry.

A plea for common sense in dentistry.


Use of a home oven in a dental office for instrument sterilization.


Area health education centers--a means of extending the dental school into communities of the state.


Immunologic response and periodontal disease.


Continuing education via television--a report.


Fibroma.

Fibroma.


Plaque control for the preschool child.

Plaque control for the preschool child.


The nurse practice act; implementation in community health setting.


The new definition of nursing in relation to nurse-midwifery.


The role of the director of nursing in creating an environment for the practice of nursing.


A new definition; implications for practitioners in school health.


A new definition; implications for the nurse anesthetist.


Nursing center for family health services.


Editorial: Beware the circling opportunists.


The role of the director of nursing in implementing the new definition of nursing.


The Associate Degree Program.

The Associate Degree Program.


A new definition--implications for curriculum planning. The Baccalaureate Program.


A new definition--implications for curriculum planning. Continuing education and baccalaureate programs.


A new definition--inplications for experimentations. Pediatric nurse practitioner program.


A new definition--implications for curriculum planning. The weekend college continuing education program.


A new definition--implications for experimentation. Family nurse practitioner program.


The role of the nursing supervisor in implementing the new definition of nursing practice.


So you've been thinking of incorporating? 3. Incorporation and management of your corporation.


A new definition--implications for curriculum planning. The Diploma Program.


Treatment of enamel with mixtures of fluorides.


Tooth form and contour.

Tooth form and contour.


Some thoughts on "socialized medicine".

Some thoughts on "socialized medicine".


X-ray films of the month. Pleural mesothelioma.


Cancer therapy--the patient's choice?

Cancer therapy--the patient's choice?


Diagnostic patterns in disability. South Carolina and the nation.


One million dollars allotted to regional medical program in S. C.


Student instructional survey. (SIS).

Student instructional survey. (SIS).


Balancing body chemistry for better success in restorative dentistry.


Filler particles of composite restorative materials.


Referring a patient for periodontal theraspy is hard work.


Myofunctional therapy. Some general observations.


Mind regional continuing dental education courses via portable videotape coverage.


The application of principles of learning to curricular design in dental education.


The tooth colored restorative materials.


Human parotid saliva proteins.

Human parotid saliva proteins.


Closed circuit T.V. in a dental office.

Closed circuit T.V. in a dental office.


Franco-American professional interrelationship in dentistry.


The vitreous carbon endosteal implant. A single tooth replacement system.


Dental administration--an outline of occlusion administration.


Thoughts concerning dental education.

Thoughts concerning dental education.


W.H.O. western pacific regional dental health program. Continuing report on dental health services--auxiliaries.


Mouth breathing. An analysis of its effect on oral health and its management.


People versus pathology. Part III.

People versus pathology. Part III.


Some considerations on psychosomatic interrelations and their repercussion in modern dentistry.


The future of dentistry and its auxiliaries--Part II.


Harmonization in dentistry of working system and equipment.


Effects of fluoride on odontogenesis of rats.


Oral manifestations as an aid in the diagnosis of systemic diseases.


Gingival recession and its prevalence.

Gingival recession and its prevalence.


Placement of an endosseous blade implant. A case report.


Periodontal involvement and caries incidence in non-institutionalized cerebral palsied patients.


Guided eruption and space control.

Guided eruption and space control.


What is your net worth today?

What is your net worth today?


The most important thing in the dental office.


Impacted maxillary cuspids: a conservative treatment approach. Case report.


Second-premolar extraction in clinical practice.


An orthodontist's visit to China.

An orthodontist's visit to China.


Class 3 malocclusion in Chinese (Cantonese): etiology and treatment.


An experimental surgical reduction of the mandible of a pig.


Clinical treatment with the Begg appliance. A case report.


Editorial: Constituent society presidents discuss issues facing orthodontics. I.


A morphological study of the invasion of liver tissue by tumour cells.


Gas chromatographic-mass spectrometric identification of N:N-dimethyltryptamine in urine samples from drug-free chronic schizophrenic patients and its quantitation by the technique of single (selective) ion monitoring.


Dynamic viscoelasticity of blood during clotting in health and disease.


Chromosomal aberrations and neoplasm--a family study.


Osteochondroma of the mandibular coronoid process. Report of a case.


Dermoid cyst with lingual sinus tract. Report of a case.


Scanning electron microscopy of the papillae foliatae of the human tongue.


Central hemangioma of the mandible and maxilla: review of a vascular lesion.


Extraosseous adenomatoid odontogenic tumor with special reference to the probability of the basal-cell layer of oral epithelium as a potential source of origin. Report of a case.


Periodontal disease, bacteria, and pulpal histopathology.


Pulpoperiapical disease: diagnosis and healing. A clinical endodontic study.


Biologic effects of dental materials. 5. Effect of cavity liners on hela cells in vitro.


Letter: Vitallium endodontic implants.

Letter: Vitallium endodontic implants.


Roentgenogram of a bullet wound.

Roentgenogram of a bullet wound.


Radiographic superimposition and suspected dentigerous cyst.


Effect of various conditions on the sublingual absorption of para-aminosalicylic acid.


Gastric acid response to sham feeding in the duodenal ulcer patient.


Fluorine-18 bone scintigraphy in children with osteosarcoma or Ewing's sarcoma.


Effects of gastro-intestinal polypeptides on hepatic bile flow and splanchnic circulation.


EDH-adhesive plastic support in the surgical treatment of tracheobronchial collapse. An experimental study and a report on clinical cases.


Development of somatosensory cortical functions. An electrophysiological study in prenatal sheep.


The early management of cleft lip and palate deformities.


Odontogenic cysts. A review and a clinicopathological study of 368 odontogenic cysts.


Further consideration of the effects of calcium sucrose phosphate on dental plaque: a telemetric study.


Erosion arising from a nutritional factor with concomitant bruxism. A clinical case report.


Dentine dysplasia.

Dentine dysplasia.


An appropriate mechanical test for dental porcelain.


Bone changes associated with the application of very low forces to incisor teeth in the guinea-pig.


Editorial: Dental Services.

Editorial: Dental Services.


Description of the region and its constraining characteristics.


The pattern of dental disease in French Polynesia.


Periodontal disease control and prevention in a public dental health programme.


Dental health education in a public dental health programme.


The delivery of dental services in the Asian Area of the Pacific Basin.


The delivery of dental services in the South Pacific Area of the Pacific Basin, especially the Island Groups and Territories.


Editorial:  A conflict of interest.

Editorial:  A conflict of interest.


Complete denture construction on an alveolar process containing endodontically treated roots.


Effect of common agents on intermediary temporary soft reline materials.


Polycarbonate resin and its use in the matrix technique for temporary coverage.


Stress transfer to the dental pulp by retentive pins.


Complicated crown fractures in adults.

Complicated crown fractures in adults.


Reinforced composite resin foundations for endodontically treated teeth.


Multiple uses of a plastic template in fixed prosthodontics.


Reflex functions of the temporomandibular joint.


Criteria and procedures for cast trimming.


An introduction to principles of veterinary clinical pharmacology: general principles.


Toxicity of bunamidine. 2. Metabolic effects.


Toxicity of bunamidine. 3. Trial of propranolol as antidote.


The isolation of Leptospira serotypes Copenhageni and Ballum from healthy calves.


The activity of enzymes in serum and tissues of clinically normal sheep.


Hypomagnesaemia in ewes treated with "agrimin" bullets.


The welfare of you and your patient is important.


Comparison of rebreathing and steady-state pulmonary DO2 in dogs ventilated by body respirator.


Bridging the gap--nursing service and nursing education.


A simple and inexpensive apparatus for halothane anaesthesia in rabbits and other small animals.


Busulfan lung. Report of two cases and review of the literature.


Immediate tonsillectomy for peritonsillar abscess.


Transposition of rotameter tubes.

Transposition of rotameter tubes.


Relation between height of the articular tubercle of the temporomandibular joint and facial morphology.


Analysis of linear facial growth.

Analysis of linear facial growth.


The size of the tongue and the intermaxillary space.


Growth variations associated with induced nasal obstruction in the albino rat.


Tonsillectomy: treatment of peritonsillar abscess.


Case history number 76: management of respiratory failure in acute pancreatitis.


Maxillary central incisor root length in orthodontically treated and untreated patients.


Periodontal condition in orthodontically treated and untreated individuals. II. Alveolar bone loss: radiographic findings.


Changes in oxygen consumption at weaning after thoracotomy and after respiratory failure.


Reproducibility of cephalometric landmarks and errors of measurements of cephalometric cranial distances.


A safe nonrebreathing system: humidity, sterility, cost.


Five-year experience with the development of an individually clean anesthesia system.


Genetic and environmental influences on the shape of the adult dog skull.


Initial tissue behavior during apical root resorption.


Letter: Neutrophilic leukemia.

Letter: Neutrophilic leukemia.


Cranial base elongation in boys during pubescence.


The therapy of acute granulocytic leukemia in patients more than fifty years old.


Further characterization of glycogen from type-IV glycogen-storage disease.


Subgingival curettage in periodontal therapy.


Experimental approximation to the determination of the true axial forces.


A correlation between force and distalization of the mandible in obtaining centric relation.


Gingival pain related to free nerve endings report of case.


Dental plaque.

Dental plaque.


A clinical assessment of the use of the free gingival graft for correcting localized recession associated with frenal pull.


Effectiveness of an ultrasonic toothbrush in a group of uninstructed subjects.


The distribution of bone defects in chronic periodontitis.


Medico-social prognosis of children with epilepsy. Epidemiological study and analysis of 245 patients.


Experiences gained in intensive care of surgical patients. A prospective clinical study of 1,001 consecutively treated patients in a surgical intensive care unit.


Preconception radiation and leukemia.

Preconception radiation and leukemia.


Chronic obstruction lung disease. Overlap syndromes and their effect on lung and cardiac function.


First case of liposarcoma from the parietal pleura.


Primary idiopathic segmental infarction of the greater omentum. Case report and review of the literature.


Lymphocyte stimulation in rheumatic fever and rheumatic carditis.


Idiopathic thrombocytopenic purpura in the first year of life.


Educational functions of the physician in private practice. Health education basic art of medical practice.


Screening for detection of childhood lead poisoning in Newark.


The gallium-67 scan in clinical assessment of cancer.


Triglyceride clearing in glycogen storage disease.


Functional disorders of the masticatory system. II. Symptoms in relation to impaired mobility of the mandible as judged from investigation by questionnaire.


The structure and distribution of nerves in the pulp-dentin organ.


Histopathology of experimental in vivo caries around silicate fillings.


Laser-induced effects on tooth structure. VI. X-ray diffraction study of dental enamel exposed to a CO2 laser.


Laser-induced effects on tooth structure. VII. X-ray diffraction study of dentine exposed to a CO2 laser.


CFU-C yields from the haemopoietic tissues of normal and leukaemic RFM mice.


Examination of the circulatory system.

Examination of the circulatory system.


Blood collection technique.

Blood collection technique.


Laboratory diagnosis by chemical methods.


Hematology for the practicing dentist.

Hematology for the practicing dentist.


Immunology and serology.

Immunology and serology.


Appendix 1. Normal laboratory values.

Appendix 1. Normal laboratory values.


Appendix 2. Selected drug interactions of concern to the dentist.


Ophthalmology for the practicing dentist.


The principles of diagnosis.

The principles of diagnosis.


An approach to the diagnosis of diseases of mouth and jaws.


Otolaryngology for the dentist. Emphasis on the physical examination and its significance.


Dermatology.

Dermatology.


Parents' descriptions of barriers faced and strategies used to obtain dental care.


What dental patients don't know about preventive care.


Fiber optics in diagnosis of osseous pathology.


Management of the hypertensive patient in dental practice.


Dentistry in a neighborhood health center: an evaluation.


Editorial: Continuing education; who needs it?


Oral cancer in a male veteran hospital population.


A case report: erythema multiforme with oral lesions only.


Report of the Manpower and Education Committee.


Evaluating the effectiveness of instruction in oral hygiene for mentally retarded boys.


Hand-Schuller-Christian disease. Report of a case.


Hamster lymphosarcomatosis and sarcomas induced by human leukemic material. I. The action of leukemic human spleen and lymph nodes suspension on Syrian hamster.


The evaluation of a machine for introducing tobacco smoke into the lungs of anaesthetized animals during spontaneous respiration.


Self-mutilating behaviors involving the oral cavity.


The transfer of endogenous and exogenous radioisotopically labelled nicotine to mainstream cigarette smoke and its absorption into the blood of anaesthetized cats.


Evaluation of the lingual ascorbic acid test.


Some implications of the critical period hypothesis.


On the definition of comparative psychology.


Ethological analysis of convergent adaptation.


Logic of mating behavior of Lepidoptera.


Nonadaptive tropisms and the evolution of behavior.


Is there a comparative psychology? The relevance of inherited and acquired constraints in the action patterns and perceptions of animals.


Experimental buckling with homologous sclera and cyanoacrylate.


The first few hours off a respirator.

The first few hours off a respirator.


"Hot pot" tracheitis.

"Hot pot" tracheitis.


Executive committee report. Statement of policy on association publications.


Food restriction as a form of child abuse in ten cases of psychosocial deprivation dwarfism.


The ADA chalk carving test.

The ADA chalk carving test.


Factor analysis of the perceptual-motor ability test.


Formal vocational experience for pre-dental students.


Dental hygiene education: a time of challenge.


Laboratory fluoride experiments in dental hygiene curriculum.


Effects of varying sequence and amount of training on learning and performance in preclinical endodontics. Part I: Design, experimental procedures, and sequencing.


Experiment in integrated teaching: group problems in oral biology.


Editorial: The Journal.

Editorial: The Journal.


Monocytic leukemia as a cause of acute respiratory obstruction.


Fetal haemoglobin levels in acute myeloid leukaemia of childhood: their value in predicting remission.


Zinc deficiency in female rabbits.

Zinc deficiency in female rabbits.


Carolinas' camp for diabetic children. I. Report of first five years of operation.


Eugenic sterilization in North Carolina.


Breast disease in a community hospital.

Breast disease in a community hospital.


Editorial: Eugenic sterilization in North Carolina.


Correlation between the mobility of inner plasma membrane structure and agglutination by concanavalin A in two cell lines of MOPC 173 plasmocytoma cells. Both the distribution of the concanavalin A-binding sites and the rearrangement of the intramembranous particles revealed by the freeze-etching technique, have been studied by means of two variants of the same cell line issued from MOPC 173 murine plasmocytoma. One variant does not agglutinate even in presence of high lectin concentration. It has been shown that the number of binding sites and affinity are almost the same in the two variants. The clustered distribution of intramembranous particles is induced by the interaction of the concanavalin A and the cell surface only in the variant which is agglutinable. From these results it became apparent that the clustered distribution of the membrane particulate components is an acquired feature of the plasma membrane accompanying cell agglutination.


Effects of 5-hydroxykynurenamine, a new serotonin metabolite, on isolated dog basilar arteries. Serotonin and 5-hydroxykynurenamine caused dose-related contractions in the spiral strips of dog basilar arteries. The potency of 5-hydroxykynurenamine was approximately 1/100 that of serotonin, the former frequently causing a transient relaxation preceding the contraction. The contractile responses to 5-hydroxykynurenamine and serotonin were attenuated by methysergide. Treatment with 5-hydroxykynurenamine inhibited the response to serotonin, and this inhibitory effect was not completely reversed by removal of 5-hydroxykynurenamine from the bathing medium. The contractile response to K(+) was only slightly attenuated by high concentrations of 5-hydroxykynurenamine. It appears that 5-hydroxykynurenamine and serotonin share receptors in dog basilar arteries and that the effect of serotonin is specifically antagonized by 5-hydroxykynurenamine.


Proton magnetic resonance and magnetic susceptibility characterization of ferredoxin I from Bacillus polymyxa. Magnetic susceptibility and proton magnetic resonance spectra are reported for the oxidized and reduced forms of the iron-sulfur protein Bacillus polymyxa ferredoxin I. The magnetic susceptibility of the oxidized form indicates antiferromagnetic exchange coupling between component iron atoms that is quantitatively similar to that observed for the clostridial ferredoxins and for the [(C(2)H(5))(4)N](2) [Fe(4)S(4)(SCH(2)C(6)H(5))(4)] analog. Contact-shifted resonances observed in the proton-magnetic-resonance spectra of oxidized and reduced forms of the B. polymyxa protein can be correlated with the contact-shifted resonances of corresponding redox forms of the clostridial ferredoxins. Characteristics of the contact-shifted resonances observed in partially reduced B. polymyxa ferredoxin I are compatible with a "slow" rate of electron exchange between redox forms, which suggests that the "fast" electron exchange earlier observed in the eight-iron clostridial ferredoxins may derive from an intramolecular component.


Tumor-host cell hybrids in radiochimeras. F(1) hybrid mice syngeneic or semiallogeneic with respect to the relevant tumor were lethally irradiated and then reconstituted with hemopoietic cells from strain CBAT6T6 mice. After chimerism had been established, the animals were inoculated with solid or ascites tumors. Tumor-host cell hybrids were selected from enzyme-deficient solid tumors by explanting the tumor cell suspension into hypoxanthine-amethopterin-thymidine containing medium. The selection of hybrid cells from ascites tumors was achieved by exploiting the difference between the ascites tumor cells and hybrid cells in their ability to adhere to the surface of culture vessels. T6T6 chromosomal and H-2 antigenic markers served to distinguish between the hemopoietic cells derived from the donor graft and the cells of the host. All solid tumors tested fused with cells of the irradiated host, whereas ascites tumors fused with repopulating cells of hemopoietic origin.


Interaction between mendelian and non-mendelian genes. Regulation of the transmission of non-mendelian genes by a mendelian gene in Chlamydomonas reinhardtii. The non-Mendelian genetic element of a given mating type of Chlamydomonas reinhardtii was first doubly marked by succesive mutageneses and then transferred into a number of offspring cells of the opposite mating type. In subsequent crosses of these offspring clones, the transmission pattern of the original non-Mendelian markers was analyzed. The results indicate that the mating-type gene of a given cell regulates the transmission and perhaps the recombination of the non-Mendelian genes regardless of whether the non-Mendelian markers were isolated originally in the same cell or obtained from another cell of the opposite mating type through genetic transmission. The regulation of the transmission of non-Mendelian genes in C. reinhardtii is thus apparently different from the autonomous control of the transmission of non-Mendelian mitochondrial genes in yeast by a genetic factor located on the mitochondrial genome.


Antibody-mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages. Humoral antibody directed against a grafted murine lymphoma can suppress the growth of the tumor in mice of the inbred strain native to the tumor. Antibody, however, cannot suppress the tumor growth in mice given 500 R of whole-body irradiation. When the tumor-antibody inoculum is admixed with lymphocytes or macrophages obtained from peritoneal exudate, macrophages experimentally rendered nonphagocytic, or with platelets isolated from peripheral blood, the tumor growth is suppressed in irradiated mice. These results indicate that mechanisms other than phagocytosis may play an important role in antibody-mediated suppression of tumor growth in vivo.


Scanning transmission electron microscopy at high resolution. We have shown that a scanning transmission electron microscope with a high brightness field emission source is capable of obtaining better than 3 A resolution using 30 to 40 keV electrons. Elastic dark field images of single atoms of uranium and mercury are shown which demonstrate this fact as determined by a modified Rayleigh criterion. Point-to-point micrograph resolution between 2.5 and 3.0 A is found in dark field images of micro-crystallites of uranium and thorium compounds. Furthermore, adequate contrast is available to observe single atoms as light as silver.


Metabolic regulation of cytoplasmic DNA synthesis. The regulation of cytoplasmic DNA synthesis by the metabolites ATP and citrate has been demonstrated. Other ribonucleoside and deoxyribonucleoside triphosphates as well as alpha,beta-methylene- and beta,gamma-methylene-ATP and alpha,beta-methylene-ADP are able to partially substitute for ATP in stimulating the rate of DNA synthesis with the cytoplasmic DNA polymerase (DNA nucleotidyltransferase, EC 2.7.7.7) from bone marrow. The fact that the methylene analogs of ATP and ADP are effective in stimulating DNA synthesis indicates that the mechanism of stimulation does not involve ATP hydrolysis. The nucleotide activators have been shown by kinetic analysis to affect the V(max) of the enzyme and not the apparent K(m)s for the substrates. The curve that results when the rate of DNA synthesis is plotted as a function of ATP concentration is sigmoidal, suggesting that more than one site on the enzyme interacts with ATP and that these sites are acting cooperatively. The concentration of ATP required for maximal velocity is dependent on the Mn(++) concentration. At pH 7.0 maximal activity is obtained when the molar ratio of ATP to Mn(++) is 1.6:1. When either ATP or Mn(++) is present in relative excess, DNA synthesis is inhibited. The mechanism of ATP activation has been shown to be associated with an alteration in the sedimentation behavior of the DNA polymerase. In the presence of ATP, there is an increase in the fraction of the enzyme that sediments at 8 S with a corresponding decrease in the 11.6S enzyme fraction. Thus, ATP activation corresponds to the dissociation of an 11.6S dimer into 8S monomers. In addition to ATP and other nucleotides, citrate also stimulates DNA synthesis. At present it is not clear whether the stimulatory effects of ATP and citrate are due to their ability to chelate Mn(++), which is inhibitory at high concentrations, or whether an ATP-Mn(++) or citrate-Mn(++) complex is the activator.


Electrostatic effects on lipid phase transitions: membrane structure and ionic environment. Ordered --> fluid phase transitions in bilayers of charged lipids are accompanied by a decrease in electrostatic free energy mainly as a result of bilayer expansion. For uniform charge distribution the Gouy-Chapman theory of the electrical double layer predicts a decrease of the transition temperature with increasing charge density. We studied the effects of pH and mono- and divalent cations on the phase transition of lecithin, cephalin, phosphatidylserine, and phosphatidic acid bilayers. Phosphatidic acid with two ionizable protons was selected for a systematic investigation. A change in pH from 7 to 9 increases the charge per polar group from one to two elementary charges. This lowers the transition temperature by about 20 degrees C in agreement with the theory. In this pH region rather small changes in pH suffice to induce the phase transition at constant temperature. Divalent cations (Mg(++) and Ca(++)) increase the transition temperature by charge neutralization and thus can be used to induce the fluid --> ordered transition at constant temperature. In contrast, monovalent cations (Li(+), Na(+), K(+)) lower the transition temperature, or fluidize the bilayer structure at a given temperature. Rather small changes in ionic environment can induce gross alterations in bilayer structure; divalent and monovalent cations have antagonistic effects. This result parallels current theories on nerve excitation and sensory transduction where cation-induced structural changes in biomembranes are invoked.


Int-constitutive mutants of bacteriophage lambda. The constitutive production of small amounts of trpB enzyme in an Escherichia coli strain carrying lambdacI857 prophage within the trpC gene has been examined in derivatives of this strain from which portions of the prophage have been deleted. Enzyme production requires a site (p(I)) within the prophage close to the left prophage end. Selection for mutants of this lysogen that grow on low concentrations of indole yielded two types of mutations within the prophage: (a) v2-type, in which all phage genes controlled by the major leftward operator are derepressed; and (b) int-c type, in which the only phage gene derepressed is int. The int-c mutations lie in the same part of the prophage as p(I). All int-c mutants appear deficient in xis gene function, even when derepressed.


The enduring behavioral changes in rats with experimental phenylketonuria. The biochemical features of phenylketonuria have been reproduced in developing rat pups by administering to them a combination of p-chloro-DL-phenylalanine plus L-phenylalanine for the first 21 days after birth. During the treatment period, the experimental animals show delayed eye opening and decreased brain weight compared with controls given saline. Neuropathological examination of developing animals reveals deficient myelination and some inhibition of cerebellar maturation. When tested as adults, after a long recovery period, animals with phenylketonuria are hyperactive in activity wheels. Adult rats are deficient in reversing a position choice and demonstrate impaired performance in a Y-maze. Rats treated with p-chloro-DL-phenylalanine plus L-phenylalanine during the vulnerable period of rapid brain development thus have enduring behavioral changes that persist throughout life.


Molecular complementarity of yeast glycoprotein mating factors. Cell fusion between opposite mating types 5 and 21 of the yeast Hansenula wingei is initiated by a strong sexual agglutination reaction. The mating factors responsible for the specificity of cellular recognition are complementary glycoproteins which form a physical complex in vitro. The complex is assayed by recovery of agglutination activity of the multivalent 5-factor after the univalent 21-factor has been inactivated by treatment of the complex with alkali. The 5-factor.21-factor complex, purified on Sepharose 6B, is large (several million daltons) and heterogeneous. The three peaks of 5-factor activity contain a number of combining sites proportional to molecular size.


Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. The 12,13-epoxytrichothecenes, a group of sesquiterpenoid fungal antibiotics, inhibit protein synthesis in eukaryotic cells but do not share a common mode of action. Trichodermin stabilizes polyribosomes, prevents their disaggregation by puromycin, and also prevents the release of nascent peptides from ribosomes by puromycin. Nivalenol, T-2 toxin, and verrucarin A cause rapid and almost quantitative breakdown of polyribosomes in H-HeLa cells, a process which is inhibited by anisomycin, cycloheximide, or trichodermin. Similar effects of trichodermin, nivalenol, and verrucarin A are also observed in yeast spheroplasts. We conclude that nivalenol, T-2 toxin, and verrucarin A are potent and highly selective inhibitors of polypeptide chain initiation in eukaryotes, whereas trichodermin inhibits chain elongation and (or) termination. We have compared the structural formulae of various trichothecenes and suggest that the presence of substituents on carbon-15 of the common trichothecene ring may be important in determining the precise modes of action of this group of compounds.