Autoradiographic evaluation of gingival response to injury. VI. Surgical trauma in long-term, low-protein-fed adult rats.


Sealing of developmental pits and fissures. II. Fluoride release from flexible fissure sealers.


A new series of x-ray-opaque reinforcing fillers for composite materials.


Laser welding of gold alloys.

Laser welding of gold alloys.


Monitoring of krypton 85 clearance from the dental pulp by means of a miniature semiconductor probe.


An implantable device for inducing bone remodeling by controlled pressure.


Sealing of developmental pits and fissures. 3. Effects of fluoride on adhesion of rigid and flexible sealers.


Determination of hydroxyapatite crystallite size in human dental enamel by dark-field electron microscopy.


Spatial distribution of cells in mitotic and DNA-synthetic phases of the cell cycle in hamster cheek pouch epithelium.


Chondroitin sulfatases in oral bacteria.


Dental arch age changes in four caucasoid population samples.


Naming a new drug: mythology, Greek etymology, and anagrams play a part.


Relationship between dental amalgam mercury content and emission.


Prevention and early detection of alcoholism.


Groove pattern and cusp number of mandibular molars from Tastilian Indians.


Management and follow-up of child abuse.


The conservative approach to ovarian enlargements.


A method of cholecystectomy and operative cholangiography.


Dissecting aneurysm with spontaneous recanalization.


Pulp viability and the homotransplantation of frozen teeth.


Radioautographic labeling in placentas and fetal palatal shelves after maternal injections of tritiated cortisone in A-Jax mice.


Thermal environment of teeth during open-mouth respiration.


Reaction of stannous fluoride with hydroxyapatite: the crystal structure of Sn 3 PO 4 F 3 .


Computerized literature searching.

Computerized literature searching.


Human pulp capping with isobutyl cyanoacrylate.


Thyromimetic medication.

Thyromimetic medication.


Effect of surface treatment on the corrodibility of dental amalgam.


Unilateral osteocardilaginous exostosis osteoma of the mandible and hyperostosis: report of a case.


The effect of surgical denervation on dentin formation in the incisor of the rat.


Laminate reinforced dental amalgam.

Laminate reinforced dental amalgam.


Effect of tetracycline on the phosphorescence of teeth.


Tooth size and position before birth.

Tooth size and position before birth.


Compression lock technique for tooth color restorations.


Permanent teeth that never erupt.

Permanent teeth that never erupt.


Cephalosporins. I.

Cephalosporins. I.


Degradation products and a unique endonuclease in heterogeneous nuclear RNA in sea urchin embryos.


Effect of concanavalin A on phagocytosis.


Responsiveness of thymus cells to syngeneic and allogeneic lymphoid cells.


Urinary steroid chromatograms from children.


Diphenylhydantoin reverses membrane effects in steroid myopathy.


Protoplasmic incompatibility: possible involvemnt of proteolytic enzymes.


Ribosomal RNA turnover in contact inhibited cells.


Variation at two loci affecting homoeologous meiotic chromosome pairing in Triticum aestivum x Aegilops mutica hydrids.


Hyperdipsia after serotonin-depleting midbrain lesions.


"New and improved instant-dental hygienists".


100,000 grandfathers.

100,000 grandfathers.


The general practitioner and preventive dentistry.


On intentional replantation.

On intentional replantation.


Particulate media.

Particulate media.


Thin films for magnetic recording.

Thin films for magnetic recording.


Magnetic memories, melodies, and mazes.

Magnetic memories, melodies, and mazes.


A systems overview of transducers.

A systems overview of transducers.


Ferrite transducers.

Ferrite transducers.


Integrated head developments.

Integrated head developments.


Magnetic tape duplication by contact printing.


Digital recording theory.

Digital recording theory.


Magneto-optics: theory.

Magneto-optics: theory.


Magneto-optics: experimental.

Magneto-optics: experimental.


An analysis on the state of AC bias recording.


Electron beam accessed memories.

Electron beam accessed memories.


Encoding and signal processing.

Encoding and signal processing.


Particulate materials versus thin film: a system overview.


Mucoepidermoid carcinoma of minor salivary glands: report of 17 cases with follow-up.


Peripheral neurectomy in the treatment of trigeminal neuralgia of the second and third divisions.


Recurrent mandibular myxoma: report of case.


Primary fibrosarcoma of the tongue: report of case.


A supplemental central incisor.

A supplemental central incisor.


Letter to the editor: oral surgery education.


Burkitt's lymphoma: report of case in New York City.


Oral surgery-a question of degree?

Oral surgery-a question of degree?


Emergency percutaneous transtracheal catheter and ventilator.


Lupus erythematosus.

Lupus erythematosus.


Genetic disorders in oral medicine.

Genetic disorders in oral medicine.


Immune response and oral disease.

Immune response and oral disease.


The extramedullary plasmacytoma, benign or malignant?


Oral candidiasis--it's diagnosis and treatment.


An appraisal of surgical orthodontics.

An appraisal of surgical orthodontics.


Clinical considerations of the periodontium.


The sella point and postnatal growth of the human cranial base.


AAO constituent society presidents consider orthodontic health proposals. I.


Representative government in professional organizations.


An electron microscopic study of the bone marrow of the rat in an experimental myelogenous leukemia.


The continuing reduction of the residual alveolar ridges in complete denture wearers: a mixed-longitudinal study covering 25 years.


A study of phonetic changes in edentulous patients following complete denture treatment.


Changes caused by a mandibular removable partial denture opposing a maxillary complete denture.


Occlusal analysis and treatment planning for restorative dentistry.


Tissue reactions to two composite resins.


Pulpal reaction to composite resin restorations.


A practical look at gold foil.

A practical look at gold foil.


Irradiated dentitions: the dentist's responsibilities.


A simplified method for multiple wax pattern duplication.


Reducing laboratory contamination.

Reducing laboratory contamination.


President's Address to The Academy of Denture Prosthetics.


Writing as a means for learning.

Writing as a means for learning.


Letter to the editor. Mandible assuming a central relation position.


Variability of proliferative patterns in acute lymphoid leukemia of children.


Exogenous lipoid pneumonia. Report of three cases with selective review of the literature.


Eosinophila and metastatic carcinoma.

Eosinophila and metastatic carcinoma.


Testicular feminization (Morris' Syndrome). Report of a case.


Hoarseness and dysphagia secondary to cervical hyperostosis. Report of an unusual case.


The diagnostic evaluation of the patient with hypoglycemic symptoms.


Progress in community health services.

Progress in community health services.


Corynebacterium vaginale. An analysis of 68 isolations.


Pneumonia and the alcoholic: an epidemiologic study.


A new clinical approach to x-ray interpretation.


The mysterious C.R.P.

The mysterious C.R.P.


Complacency and statistics.

Complacency and statistics.


Dentistry and cleft palate patients.

Dentistry and cleft palate patients.


Selective condensation of aminoacyl adenylates by nucleoproteinoid microparticles (prebiotic-lysine-model system-genetic code). Microparticles composed of each of four enzymically synthesized homopolynucleotides and the same lysine-rich proteinoid have been found to influence the condensation of the AMP-anhydrides of each of four amino acids. The conditions of preparation of the particles and other variables of the experiments control the types of reaction. When a specified set of conditions was identified empirically, the incorporation favored the amino acids whose present-day codons are related to the homopolynucleotide in the particle.


Geometry of the first step in the action of ribonuclease-A (in-line geometry-uridine2',3'-cyclic thiophosphate- 31 P NMR). Advantage was taken of the reversibility of the first step of ribonuclease-A action to synthesize the dinucleoside phosphorothioate Up(S)C from the crystalline isomer of uridine 2',3'-cyclic phosphorothioate [Up(S)] and cytidine. Cyclic phosphorothioate was then reformed from Up(S)C by a nonenzymic reaction known to proceed by an in-line mechanism. The geometry of the enzymic reaction was determined to be in-line by a comparison of the Up(S) product with the Up(S) originally used. By the principle of microscopic reversibility, the geometry of the first step in the action of ribonuclease-A is shown to be in-line.


Fate of mitochondrial DNA in human-mouse somatic cell hybrids (density gradient centrifugation-ethidium bromide-karyotype). Several hybrid lines between human and mouse somatic cells, containing one or two complements of mouse chromosomes and a reduced complement of human chromosomes, have been examined for the presence of mouse and human mitochondrial DNAs. For this analysis, advantage was taken of the fact that these two types of mitochondrial DNA have a buoyant density difference in CsCl gradients of 0.008 g/cm(3). In all the hybrid clones analyzed, which retained an average number of human chromosomes estimated conservatively to vary from 5 to 23, only mitochondrial DNA of mouse character was detected. It seems likely that either repression of relevant human genes by the mouse genome or loss of human chromosomes is responsible for these results. If the latter explanation is true, since chromosome loss under the conditions used here was substantially a random process, one would have to assume that the activity of nuclear genes distributed in many chromosomes is required for the survival of mitochondrial DNA.


Evidence of gene diminution during the formation of the macronucleus in the protozoan, Stylonychia (DNA density-melting curves-micronuclear DNA-polytene chromosomes). The course of events by which a macronucleus is formed from a micronucleus after conjugation in the ciliated protozoan, Stylonychia, suggests that genetic diminution may occur. This idea is supported by determinations of the density profiles and melting curves for micro- and macronuclear DNAs. Macronuclear DNA consists of a single density component and melts as if it were a single component. Micronuclear DNA consists of four or more density components and melts as if it were a mixture of several DNAs of different base compositions. These data indicate that at least 60% of the micronuclear DNA components are absent from the macronuclear DNA.


Early estrogen action: stimulation of the metabolism of high molecular weight and ribosomal RNAs (estradiol-17 -RNA isolation-uterus-ribosomal RNA precursors-actinomycin D). Samples of RNA, isolated from uteri of ovariectomized adult rats treated with estrogen, have been analyzed on sucrose gradients. Treatment with estrogen either for 20 min or 2 hr increased the specific activity of all classes of uterine RNA, but produced no significant alteration in the distribution of radioactivity in the gradients, when animals received [(3)H]uridine intraperitoneally 15 min before they were killed. After labeling periods of 30 min, 1 hr, or 2 hr, however, the RNAs isolated from animals treated with estrogen had a smaller percentage of rapidly sedimenting (faster than 28S) species of RNA than did RNA from animals not treated with the hormone. The decreased percentage of high molecular weight RNA correlated with increases in both the specific activity of 28S and 18S RNA and the concentration of RNA in the whole organ. The labeled RNA of high molecular weight was also demonstrated, by the use of actinomycin D in vivo, to have a more rapid turnover rate in the estrogen-stimulated uterus. Our results indicate that estrogen increases not only the rate of synthesis of ribosomal RNA in the uterus of the ovariectomized adult rat, but also the rate or efficiency of processing of precursor RNA species of high molecular weight.


Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na +  and K +  gates). The technique of reversible equilibrium dialysis has been applied to the study of macromolecules that are essential for axonal conduction. A binding component from a preparation of an axon-plasma membrane has been characterized and shown to bind nicotine with a K(D) = 0.42 +/- 0.04 muM and to the extent of 0.7 nmol/g of wet nerve. This binding was competitively blocked by acetylcholine (K(i) = 43 +/- 7 muM) and procaine (K(i) = 2.9 +/- 0.2 muM). This axonal macromolecule exhibits several of the properties of cholinergic postsynaptic receptors including its concentration in the tissue, blockade of its binding of nicotine by cholinergic drugs and alpha-bungarotoxin, and its phospholipoprotein nature. Some important differences are a lower affinity for acetylcholine and its binding of procaine. It is suggested that this nicotine receptor is on the internal surface of the axon plasma membrane and is a component common to both the Na(+) and K(+) gates.


Noncooperativity of the    dimer in the reaction of hemoglobin with oxygen (human-dissociation-equilibrium-sulfhydryl-absorption-x-ray analysis). The theory that the alphabeta dimer is the functional unit of cooperativity in hemoglobin has been tested by determination of the oxygen equilibrium curve of stable deoxy dimers, obtained by the addition of 0.9 M MgCl(2) to human des-Arg 141alpha-hemoglobin. Cooperativity was absent in this medium, but was regained on transfer of the hemoglobin to a dilute phosphate buffer, where tetramers reformed. X-ray analysis of crystals of oxy- and deoxy-des-Arg hemoglobins showed that the removal of Arg 141alpha would leave the structure of alphabeta dimers unchanged. Nonreactivity of the sulfhydryl groups at 112beta proved that the subunits in deoxy dimers form the same contact as in oxy dimers, namely alpha(1)beta(1), and that no significant dissociation into free subunits occurs in 0.9 M MgCl(2). The absorption spectrum of the deoxy dimers corresponded to the sum of the spectra of the free deoxy alpha and beta subunits, and was different from that of the deoxy tetramer, showing the constraining salt bridges formed by the C-terminal residues in the tetramer to be necessary for the spectral changes normally observed on association of the deoxy subunits.


Preparation of dialyzable histocompatibility antigen from BALB-c mice (cell-membrane fragments-proteolytic digestion-detergent solubilization). Histocompatibility antigens solubilized from cell-membrane fragments of BALB/c mouse spleen and liver, by Triton X-100 and butyl alcohol, were subjected to digestion by proteolytic enzymes in an effort to obtain smaller molecular species that retained antigenic activity. Digestion with both trypsin and papain yielded two antigens of smaller molecular weights that retained the specificity of BALB/c histocompatibility antigen, as determined by the inhibition of allogeneic antibodies, agglutination of BALB/c erythrocytes, adsorption-hemagglutination versus the soluble histocompatibility antigen, and suppression of the ability of BALB/c spleen cells to produce hemolytic plaques to sheep erythrocytes. The two active products of trypsin digestion were, respectively, excluded by Sephadex G-50 but not by G-75, and excluded by G-25 but not by G-50. Papain digestion yielded one active antigen that was excluded by G-25 but not by G-50, and a smaller antigen that was excluded by G-10 but not by G-15 and, as determined by gel filtration, has a molecular weight slightly lower than vitamin B(12).


Nucleotide sequencing of DNA: preliminary characterization of the products of specific cleavages at guanine, cytosine, or adenine residues (bacteriophage M13-ribosubstitution-DNA polymerase I-electrophoresis-two-dimensional fingerprinting). DNA synthesized in vitro from a phage M13 template has been cleaved at either guanine, adenine, or cytosine residues by ribosubstitution techniques. Fingerprints of the fragments obtained suggest that DNA sequencing will be possible with this technique.


Kinetics of the reduction of metalloproteins by chromous ion (laccase-cytochrome c-plastocyanins-temperature-rate constants). The reduction of Cu(330) in Rhus vernicifera laccase by chromous ion is 30% faster than reduction of Cu(614) at room temperature [pH 4.8, mu = 0.1 (NaCl)], and two parallel first-order paths, attributed to heterogeneity of the protein, are observed at both wavelengths. The reactions of stellacyanin, spinach and French-bean plastocyanins, and cytochrome c with chromous ion under similar conditions are faster than that with laccase by factors of 10(2) to 10(4), and are first order in protein concentration. Comparison of rates and activation parameters for the reduction of "blue" copper in laccase, stellacyanin, and the two plastocyanins indicates that reduction of the Cu(614) site in laccase may occur by intramolecular electron transfer from one of the Cu(330) sites. Our value of DeltaHdouble dagger (17.4 kcal/mol) for the chromous ion reduction of cytochrome c is consistent with a mechanism in which major conformational changes in the protein must accompany electron transfer.


Defective formation of the lamellar cytoplasm by neoplastic fibroblasts (L cells-transformed cells-cell attachment-contact inhibition-scanning electron microscopy-microcinematography). Isolated cultures of mouse L-cells are similar to those of normal cells in showing contact inhibition of movement and topoinhibition of growth. In mixed cultures with untransformed mouse embryo fibroblasts, their parent strain, however, L cells are able to form colonies above the monolayer of normal fibroblasts, i.e., they have a property characteristic of transformed cells. Analysis of microcinematographic data suggests that the behavior of L cells in mixed cultures is a result of their defective attachment to the substratum. Scanning electron microscopy showed that attachment of a normal fibroblast was accompanied by the formation of a wide ring of flattened cytoplasm spread on the substratum (lamellar cytoplasm). This structure was observed to disintegrate in newly attached L cells. The structure of the lamellar cytoplasm remained abnormal in the fully spread L cells. The mean area of lamellar cytoplasm was 3- to 4-times less in L cells than in normal fibroblasts. It is suggested that deficient formation of lamellar cytoplasm may be the basis of the inability of L cells to interact normally with embryo fibroblasts.


Cell separation on affinity columns: the isolation of immunospecific precursor cells from unimmunized mice (lactoside hapten-lymphocyte receptors-immunology). We have used affinity columns to isolate from the spleens of unimmunized mice a population of lymphocytes that specifically bind a lactoside hapten. These cells are able to initiate an antibody response to azophenyl-beta-lactoside when transferred to appropriate irradiated recipients.


Nonrandom X-chromosome inactivation--an artifact of cell selection (mouse chimera). The present study shows that a high degree of variability in the distribution of XX and XY cells exists among various tissues of artificially assembled or spontaneously occurring mouse chimeras. This variation from the expected equal distribution in various tissues of an animal may have resulted from random distribution, unequal segregation, or selective differences of such cells during development. This variation may also explain the observed intertissue and interanimal variations in the distribution of inactive paternal and maternal X-chromosomes in some mammalian females.


Matching sequences under deletion-insertion constraints. Given two finite sequences, we wish to find the longest common subsequences satisfying certain deletion/insertion constraints. Consider two successive terms in the desired subsequence. The distance between their positions must be the same in the two original sequences for all but a limited number of such pairs of successive terms. Needleman and Wunsch gave an algorithm for finding longest common subsequences without constraints. This is improved from the viewpoint of computational economy. An economical algorithm is then elaborated for finding subsequences satisfying deletion/insertion constraints. This result is useful in the study of genetic homology based on nucleotide or amino-acid sequences.


Cytogenetic analysis of the first cleavage division in mouse embryos (fertilization-pronuclei-T163H translocation). Chromosome counts of 338 mouse zygotes at late prophase and metaphase of the first cleavage division revealed 96.4% diploidy, 1.8% hypodiploidy, 1.2% triploidy, and 0.3% tetraploidy. One additional anomaly might have given rise to an embryo mosaic for maternal but not paternal genes. In zygotes collected without colchicine administration to the mother, one of ten anaphases had a lagging chromosome. Reciprocal crosses with the translation T163H as a marker chromosome at late prophase, when the male- and female-derived chromosome groups have not yet combined, demonstrate that the group derived from the larger pronucleus and having less condensed chromosomes is of paternal origin. T163H undergoes Mendelian segregation in female heterozygotes.


Cytological mapping of human X-linked genes by use of somatic cell hybrids involving an X-autosome translocation (mouse-hamster-human X-linked markers). Man-mouse and man-Syrian hamster somatic hybrid cell lines were prepared by fusion of mouse A9 or hamster TG2 cells, which are deficient in hypoxanthine-guanine phosphoribosyl transferase, with cells of a diploid fibroblastic strain, KOP-1, derived from a woman heterozygous for an X-autosome translocation. 61 clones were derived in nonselective medium and 85 sublines of these were derived in selective media: 53 in hypoxanthine-aminopterine-thymidine and 32 in 8-azaguanine. All three human X-linked markers studied, i.e., hypoxanthineguanine phosphoribosyl transferase (EC 2.4.2.8), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), and phosphoglycerate kinase (EC 2.7.2.3), were present together, or absent together, in most of these clones and sublines. However, loss or retention of only phosphoglycerate kinase was occasionally observed, even in the absence of selective growth, while no evidence of separation of hypoxanthine-guanine phosphoribosyl transferase from glucose-6-phosphate dehydrogenase occurred. Cytological examination of eight man-hamster clonal lines by the quinacrine fluorescent technique showed that human phosphoglycerate kinase was only present when the translocation chromosome carrying most of the long arm of the X chromosome was present. The presence of human glucose-6-phosphate dehydrogenase and hypoxanthine-guanine phosphoribosyl transferase was not related to the presence or absence of this chromosome, but appeared to be correlated with the presence of the other translocation chromosome.


A partial sequence of nuclear events in regenerating rat liver (gene regulation-chromosomal RNA). When two lobes of the liver of the adult rat are removed, the cells of the remaining lobe are aroused to renewed cell division. We have studied the early events in such regeneration. The first observable response to such partial hepatectomy is the production in the liver nuclei of rapidly-labeled high-molecular-weight RNA of sequences not produced by normal liver. This is followed, with a lag of about 1 hr, by the appearance of increased (above normal) amounts of chromosomal RNA, again of sequences not produced by normal liver. With a lag of another hour, the template activity in support of RNA synthesis of the liver chromatin increases substantially. These events occur before initiation of DNA synthesis in the cells of the regenerating liver.


Secular trends in different racial groups.


Genetic modification of electric properties in an excitable membrane (paramecium-calcium conductance-electrophysiological measurements-membrane mutant). A behavioral deficiency produced by a single gene mutation in Paramecium aurelia was traced to impaired electric excitability of the cell membrane. Evidence is presented that the mutant membrane does not exhibit the normal depolarization-activated increase in calcium conductance responsible for regenerative depolarization in the wild type. Other electric properties characteristic of the wild-type membrane remain normal in the mutant.


Gingival condition associated with orthodontic treatment.


Norms of size and annual increments of the sphenoid bone from four to sixteen years.


Relationship between the lingual of the maxillary central incisor and the articular eminence in ideal occlusions.


A histologic study of pulpal reaction to orthodontic tooth movement in dogs.


Biology of the orthodontic patient. 3. Relationship of chronologic and dental age in terms of vitamin C state.


Case report: surgical repositioning of the free and floating premaxilla.


Muscle contraction patterns in swallowing.


Selection of the square and rectangular wires in clinical practice.


The role of the invariant segment in orthodontic diagnosis and treatment planning.


The malignant change in chronic wounds.

The malignant change in chronic wounds.


The physician as a vocational evaluator and advisor.


Heat stress and heat strain.

Heat stress and heat strain.


Patterns of drug abuse epidemiology in prisoners.


Some effects of 2,4-D and 2,4,5-T on Ehrlich ascites tumor cells in vivo and in vitro.


Primary herpes simplex infection of the finger: report of case.


Fluoridation and environment.

Fluoridation and environment.


Effective sedation and local anaesthesia for high risk cardiac patients.


The utilization of mouth-protectors by freshman football players.


Behavioral characteristics of disadvantaged adult patients.


Interaction of dental students with the educational environments provided by preventive and community dentistry; realism and reasonableness of the educational planning and implementation.


A private group practice utilizing capitation prepayment.


The systems-approach to a community dental clinic.


The projected financial savings in dental restorative treatment; the result of consuming fluoridated water.


Public and professional acceptance of auxiliaries.


A new method of presurgical hand cleansing.


Clinical evaluation of a syringe-loaded gun.


Anterior Z-plasty ridge extension.

Anterior Z-plasty ridge extension.


Arteriovenous malformations of the anterior mandibular gingiva. Use of the Doppler ultrasonic flowmeter for delineation of the lesions at surgery.


Oral manifestations of hemochromatosis. Report of a case.


Oral manifestations of histoplasmosis.

Oral manifestations of histoplasmosis.


Electron microscopy and histochemistry of pemphigus and pemphigoid.


Focal epithelial hyperplasia: a virus-induced oral mucosal lesion in the chimpanzee.


Focal epithelial hyperplasia in an Eskimo population.


A comparison of paralleling and bisecting radiographic techniques as experienced by dental students.


Antibacterial efficacy and cytotoxicity of three endodontic drugs.


Internal resorption.

Internal resorption.


Lymphoblastic lymphosarcoma. A radiation therapy case report.


Bony erosion of the palate.

Bony erosion of the palate.


Keratocyst of the maxilla.

Keratocyst of the maxilla.


The effect of orally administered zinc sulfate on extraction wound healing in hamsters.


Lifting forces associated with contact lenses.


Accidental closure of the expiratory outlet in the Engström ventilator (200) during anaesthesia. A case report.


Some of the time factors associated with stereopsis.


Experimental deformation of the in vivo cornea.


The gel lens--transferred corneal toricity as a function of lens thickness.


Eye movement recordings as a diagnostic tool in a case of congenital nystagmus.


Adaptation to corneal contact lenses: profile of clinical tests.


Social tracking in the development of educational visual skills.


The use of contact lenses in children and infants.


After-image transfer: a therapeutic procedure for amblyopia.


Selenium and tellurium in mice. Effects on growth, survival, and tumors.


Histopathology of experimental in vivo caries around silver amalgam fillings.


Modification by orthophosphate of the transfer of tooth phosphorus into cariogenic streptococci.


The broad view of education in the health professions and its relation to national needs and higher education.


The products of dental education (curriculum: design and setting).


Discrimination indexes for improving dental school admissions.


The Friends of American Association of Dental Schools.


Validity: quantitative, qualitative, and quasi.


Visuo-spatial ability, dental aptitude tests and multiple-choice practical examinations in oral pathology.


Clinical evaluation and grades.

Clinical evaluation and grades.


The problem of weighting student scores.


My resignation.

My resignation.


More meaningful measurement or skills+knowledge+attitudes=?


Guidelines for teaching the comprehensive control of pain and anxiety in dentistry. American Dental Association, Council on Dental Education, May, 1971.


Computer aided instruction of statistics to dental students.


The problem of academic promotions.

The problem of academic promotions.


Biomechanics--the neglected dental entity.


Shortages in dental manpower: a problem of maldistribution.


District Council 37 drops its suit for injunction.


The second decade of biomaterials development and evaluation: a time to apply the scientific method.


The events that lead to thrombosis.

The events that lead to thrombosis.


The role of electrochemical surface properties in thrombosis at vascular interfaces: cumulative experience of studies in animals and man.


The role of flow in thrombogenesis.

The role of flow in thrombogenesis.


The role of surface energy in thrombogenesis.


What factors determine thrombogenicity.

What factors determine thrombogenicity.


Criteria for financial support of studies evaluating blood compatibility.


Performance of materials as prosthetic blood vessels.


Performance of materials in vascular prosthetic devices: heart valves.


The performance of membranes in vascular prosthetic devices.


Components of artificial hearts.

Components of artificial hearts.


Some methods for in vitro estimation of the blood compatibility of biomaterials.


The use of resonating devices to make small mass measurements.


Control of flow in the evaluation of blood compatibility of biomaterials.


Ultrasonic detection of microemboli from artificial surfaces: evidence of microembolic tissue damage.


The use of pathologic techniques in the evaluation of emboli from prosthetic devices.


Standardized methods for the in vivo evaluation of artificial surfaces.


Tax reform and the dentist.

Tax reform and the dentist.


Control of post-extraction bacteraemias in the penicillin-hypersensitive patient.


Pemphigus vulgaris: the role of the dentist in its management.


An analysis of 105 dental cysts.

An analysis of 105 dental cysts.


The fourth canal in maxillary first molars.


Equipment: the good and the dangerous.

Equipment: the good and the dangerous.


A viewpoint for expanded duties of auxiliaries.


Dentists should stand up and say "no" once in a while.


You and your family dentist.

You and your family dentist.


Plaque control and human nature.

Plaque control and human nature.


Address: Analysis of important questions facing dentistry.


Granulopoiesis in chronic granulocytic leukaemia.


Platelet and fibrinogen kinetics with ( 75 Se)-selenomethionine in patients with myeloproliferative disorders.


Regression of stem-cell erythroblastic leukemia after hypophysectomy.


Enzymatic estimation and metabolism of 1- -D-arabinofuranosylcytosine in man.


The effects of phenylalanine ammonia-lyase on leukemic lymphocytes in vitro.


In vitro studies on heme synthesis by bone marrow and spleen cell suspensions from an acute myelogenous leukemia in the rat.


Dentistry and national health insurance.


The dentist and the marketing game.

The dentist and the marketing game.


Commitment: it's effect on you.

Commitment: it's effect on you.


A building called "learning" resources.

A building called "learning" resources.


Mother is a dental student.

Mother is a dental student.


Presenting... Oral Disease Control to a group.


A plea for greater earnestness in the study of underlying principles and in the practice of dentistry.


Neoplasms of the major salivary glands.

Neoplasms of the major salivary glands.


Minor tooth movement.

Minor tooth movement.


Treatment of the palatally impacted permanent maxillary cuspid.


Dentistry: a hazardous profession.

Dentistry: a hazardous profession.


Determination of fees for removable partial prosthesis.


States have the right...

States have the right...


Orthodontics by computer.

Orthodontics by computer.


Ethics and the dental student.

Ethics and the dental student.


ADA at work on prevention.

ADA at work on prevention.


Strengthening peer review. Council on Dental Care Programs.


An Easterner looks at the American Dental Association.


Unsterile local anesthesia.

Unsterile local anesthesia.


Orthodontic group starts 200,000 dollar fund.


AFDE sees substantial growth in 1972.

AFDE sees substantial growth in 1972.


Association programs emphasizing prevention for the profession and the public.


Should plaque control be added to prepayment plans? Maybe.


Should plaque control be added to prepayment plans? YES.


Dimensions of the focal trough in panoramic radiography.


Drug interactions: a professional responsibility.


Specialization in dentistry: a need for policy revision.


The Army medical irrigator and the hydroscrub device.


Fatality after use of alphaprodine in analgesia for dental surgery: report of case.


Palatal necrosis secondary to cytotoxin therapy: report of case.


1971 Survey of Dental Practice. IV. Professional expenses.


Clinical aids.

Clinical aids.


Retention can be less of a problem.

Retention can be less of a problem.


Patient motivation.

Patient motivation.


Dental esthetics.

Dental esthetics.


Swagings. Materials required for swaging orthodontic bands.


JCO visits Dr. Lyman E. Wagers.

JCO visits Dr. Lyman E. Wagers.


The Registrar's report.

The Registrar's report.


Open your office doors.

Open your office doors.


Would you consider leasing? Leasing offers new practice way of conserving capital.


Why a fee schedule would be impractical in orthodontics.


Orthodontic treatment procedures according to the philosophy of Dr. Charles Tweed.


A truly new but tested concept in mixed dentition and full dentition treatment.


The implant technic including history, relative accuracy and information derived and applied to orthodontic patients.


Clinical pathological conference: osteosarcoma.


Oral cancer. 5. Therapy.

Oral cancer. 5. Therapy.


Preventive orthodontics. 4. Anomalies of spatial and temporal origin.


Systematic intake of fluoride and preventive dentistry. 5. Water fluoridation and Los Angeles: present and future.


Peer review and prepaid dental insurance. 5. Prevention pays here also.


Professional judgement a "must" in nutritional awareness. V.


Omniflex and fixed prosthodontics...a review of recommendations.


Intravenous amnesia in a patient with sickle cell anemia: case report.


The D.A. basics...a brief refresher.

The D.A. basics...a brief refresher.


Let's be practical about "mobility".

Let's be practical about "mobility".


Recognition of periodontal disease.

Recognition of periodontal disease.


Things ain't the same anymore.

Things ain't the same anymore.


A schedule for periodontal therapy.

A schedule for periodontal therapy.


Factors considered in periodontal involvement.


Methoxyflurane analgesia for dental patients.


Contamination of local anesthetic carpules by storage in alcohol.


Valium--a valuable drug for dentistry.

Valium--a valuable drug for dentistry.


Togetherness is the student family clinic.


Testing the effectiveness of behavioral objectives in dental assistant education.


Laboratory exercises for dental radiographers.


4-Series on plaque control, instruction for the dental team-Mr. Yablonski sees the need.


Test yourself-are you getting the most out of your work?


Preventive dentistry: is it working?

Preventive dentistry: is it working?


The specialists talk back...about the GPs.


Should the dentist invest in drilling funds?


Is your wife prepared to be a widow?

Is your wife prepared to be a widow?


Practice administration.

Practice administration.


Losing patience (sp?) with your office?

Losing patience (sp?) with your office?


A shade guide for your office decor.

A shade guide for your office decor.


Why settle for second rate?

Why settle for second rate?


The office orphan--the desk area.

The office orphan--the desk area.


Reception rooms that smile.

Reception rooms that smile.


The teen-geared office.

The teen-geared office.


Have office, will travel.

Have office, will travel.


Beautiful office--building time: one day.


Tip toe through the timbers.

Tip toe through the timbers.


Your role in office decor.

Your role in office decor.


Interest sags on issue of national health care.


Designing tomorrow's dental office today.


Non-operative treatment for gingival erosion.


The selection and placement of cavity liners and bases.


Dental office fires spur safety warning.


Effects of Milwaukee brace on dentition, facial growth.


Single-ownership group practice: "the best of two worlds".


Prevention: practice what you preach.

Prevention: practice what you preach.


The use of visual power in "total patient" diagnosis.


Way of life: the dentist as a person.

Way of life: the dentist as a person.


Dentist blends practice with family's career in folksinging.


Modern offices designed for comfort, with maintenance held to minimum.


Antacid therapy for peptic ulcer.

Antacid therapy for peptic ulcer.


President of the oral surgeons advises on lawsuits and malpractice insurance.


Some thoughts concerning dental auxilary utilization.


Caries risk in teeth with orthodontic bands: a review.


Prevalance of interdental spaces in pre-school children.


Surgical correction of anterior open bite: a case report.


Behavior-response technique in dental health education.


Dental abnormalities in cases of cleft lip and palate.


Tax tips.

Tax tips.


Dentistry in the 1970's.

Dentistry in the 1970's.


A private group practice utilizing capitation prepayment.


Your oral pathology service from 1962-1970. I. Survey of cases submitted for microscopic diagnosis.


Modernization of the dental treatment environment.


Preventive dentistry--quo vadis?

Preventive dentistry--quo vadis?


Application of the index of production.

Application of the index of production.


Case report: immediate acrylic tooth implant.


Dental health education a dimension of the profession.


Illusion and reality in dental health education.


General principles of school dental health education.


Patient education in the dental office.

Patient education in the dental office.


Professionalism and education.

Professionalism and education.


Law and economics of a dental practice.

Law and economics of a dental practice.


Fluoridation surveillance program Nebraska state department of health.


Pathologist's corner...oral cancer; the vicious killer.


Maschka-health insurance.

Maschka-health insurance.


Dr. Cohen at the helm.

Dr. Cohen at the helm.


Filling an advisory cavity.

Filling an advisory cavity.


National health policies.

National health policies.


Hygienists in periodontics.

Hygienists in periodontics.


What's new in flexible partials?

What's new in flexible partials?


Espanola hospital staff opposes H.M.O.'s.


The world of women dentists as seen by one of the 1.2 percent practicing dentistry.


What's your diagnosis? Leukoplakia.

What's your diagnosis? Leukoplakia.


Effective communication.

Effective communication.


A new profession: dentistry (with apologies to the future).


Dental recruitment is still a big problem.


New film on immediate dentures.

New film on immediate dentures.


Dental care of the elderly.

Dental care of the elderly.


A-Z of practice management. A is for administrator.


No advantages in trading excesses.

No advantages in trading excesses.


Hospitals and health centers in community health: USC Health Services Center Program.


Black political strategy for 1972.

Black political strategy for 1972.


Procedures in oral surgery. Cysts in the oral and jaw regions.


Nitrous oxide analgesia--a method for the restorative treatment of patients. Case report.


The filling material TD 71 in dental practice.


Occlusal prophylaxis in porcelain constructions.


An unpromising case solved by simple means.


A dentoform for testing the action of fixed orthodontic appliances on the dental arch.


Interpretation of radiographs.

Interpretation of radiographs.


Scaling with ultrasound.

Scaling with ultrasound.


Dental ergonomics 1971--the present state.


Optimal only through true teamwork. Experiences of the ZISE seminars in Koblenz.


Present status and plans for the future of drinking water fluoridation in the Socialist nations of Europe.


Central neurogenic mandibular tumors.

Central neurogenic mandibular tumors.


The modern laboratory--a basis for progressive development.


Procedures in oral surgery. Mandibular radicular cysts.


Separable magnet obturator for closure of a large cystic cavity in the mandible.


A new silicone elastomeric material.

A new silicone elastomeric material.


Hypnosis in dentistry.

Hypnosis in dentistry.


Retention of a fractured root.

Retention of a fractured root.


Procedures in oral surgery. Maxillary radicular cysts.


Phases in commercial amalgam alloys.

Phases in commercial amalgam alloys.


Irritation of the mental nerve after root canal therapy on the left mandibular second premolar.


A new method of esthetic denture design.


Functional temporary partial dentures.

Functional temporary partial dentures.


Laser welding of prostheses--an initial report.


Attachment of a complete lower denture to a series of endosseously implanted pins.


Interpretation of radiographs.

Interpretation of radiographs.


Preoperative occlusal adjustment in prognathism.


The dentist as a personality.

The dentist as a personality.


Should the mouth spray contain additives?


A new proposal to combat illicit dentistry.


Sex and the upper central incisor.

Sex and the upper central incisor.


Familiarity breeds carelessness.

Familiarity breeds carelessness.


Will they steal your car next?

Will they steal your car next?


Virginia oral exfoliative cytology program: a clinical and histological evaluation.


The rise and fall of dental hygiene.

The rise and fall of dental hygiene.


Muscle degeneration produced by local anesthetics.


Federal price-wage freeze and you.

Federal price-wage freeze and you.


Compulsory continuing education.

Compulsory continuing education.


Organization: the key to happy endodontics.


Acute leukemia due to chronic exposure to benzene.


Heparin treatment for the hemorrhagic diathesis of acute promyelocytic leukemia.


Why art in orthodontics?

Why art in orthodontics?


Perspective. "Assembly line" revisited.

Perspective. "Assembly line" revisited.


Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases.


Tax tips.

Tax tips.


Coroner asks dentists be alert to rare but dreaded condition.


Dental fees taxable in year of billing.

Dental fees taxable in year of billing.


Notes on the care of patients receiving general anaesthesia for routine dentistry.


In vitro-in vivo correlation of drug metabolism--deamination of 1- -D-arabinofuranosylcytosine.


Cataract after busulphan treatment.

Cataract after busulphan treatment.


Ecology--is for dentists too.

Ecology--is for dentists too.


Leukemia on myeloma.

Leukemia on myeloma.


Education for the dental practitioner.

Education for the dental practitioner.


Crossbite and its management.

Crossbite and its management.


Oral cancer. IV. The diagnosis.

Oral cancer. IV. The diagnosis.


Preventive dentistry and plaque control. IV. "You can lead a horse to water--but he won't drink unless he wants to.


Preventive orthodontics. 3. Intrinsic factors.


The national scene. IV. Dental care consideration in national health insurance.


Peer review and prepaid dental insurance. IV.


Navy preventive program. IV. Mass fluoridization.


Systemic intake of fluoride and preventive dentistry. IV. Fluorides in development of dentition.


Improving delivery of dental health care: the role of the federal government.


Soft sell.

Soft sell.


Contemporary babbitry--ecology now.

Contemporary babbitry--ecology now.


Taxes. The dental firing line.

Taxes. The dental firing line.


Your '72 morale boosting. The d.a.

Your '72 morale boosting. The d.a.


A military dental officers attitude survey.


Dentistry at sea.

Dentistry at sea.


The German dental industry in 1971.

The German dental industry in 1971.


Ergonomics 1971--an analysis of the current state.


Roentgenographic technique.

Roentgenographic technique.


Consumers' criticism of U. S. health care system.


Cigarette smoking and the role of dentists.


Fifty years of service to children.

Fifty years of service to children.


An evaluation of long-term benefits of dental treatment for dento-facial handicapped children in Colorado.


Continuing education--farce or force?

Continuing education--farce or force?


New dental school recognized.

New dental school recognized.


Current uses of cements in dentistry.

Current uses of cements in dentistry.


"Changing concepts in periodontal therapy 1972." 1.


What is your diagnosis? Squamous papilloma.


Summary of Kansas orthodontic history.

Summary of Kansas orthodontic history.


Case report: odontalgia resulting from prodromal herpes zoster.


The Character Reference Program.

The Character Reference Program.


The establishment pays off.

The establishment pays off.


Professionalism and the annual meeting.

Professionalism and the annual meeting.


Vague unexplained mandibular and TMJ discomfort.


Important findings revealed concerning oral irrigation devices.


Dental futures: Calculated risks.

Dental futures: Calculated risks.


Topical fluorides for the individual patient.


Are you incorporated? Ethical or unethical?


Ethical requirements pertaining to the use of corporate designations as part of dentists' practice names.


Dental caries inhibition by fluorine--the historical perspective.


The use of implants in dentistry today.

The use of implants in dentistry today.


The health questionnaire in general dental practice. 8. Diabetes and dentistry.


Newer trends in intra-operative blood replacement.


Tachypnea and alkalosis in infants of narcotic-addicted mothers.


Treatment of facial trauma.

Treatment of facial trauma.


Cholecystogastrocolic fistula.

Cholecystogastrocolic fistula.


Self-inflicted stab wounds to pregnant uterus and fetus at term.


State Board Report.

State Board Report.


Dentistry and society--V.

Dentistry and society--V.


Electrocardiograms of the month.

Electrocardiograms of the month.


Gastric secretory response to pressure on vagal nuclei.


A successful program of hearing conservation for industry.


Health problems of industrial workers in Egypt.


Detecting disease by biochemistry of blood.


Vacationing with diabetes, not from diabetes.


New two-minute pregnancy test.

New two-minute pregnancy test.


Position statement--contact lenses in industry.


Current status of breast cancer.

Current status of breast cancer.


Proliferative activity of human granulocytes, as estimated quantitatively by in vitro colony formation.


Current status of chemotherapy.

Current status of chemotherapy.


Pulmonary aspergillosis.

Pulmonary aspergillosis.


Total ventilatory support in a quadriplegic patient with radiofrequency electrophrenic respiration.


Twenty-seven year old mother with amenorrhea and lower abdominal pain.


85 Sr bone scan in neoplastic disease.

85 Sr bone scan in neoplastic disease.


Production within the rumen and removal from the blood-stream of volatile fatty acids in sheep given a diet deficient in cobalt.


Marrow studies with radiocolloids.

Marrow studies with radiocolloids.


Halfway houses.

Halfway houses.


Scanning the reticuloendothelial system (RES) in hematological diseases.


Delivery of ambulatory care.

Delivery of ambulatory care.


Surgicenters.

Surgicenters.


Uniform alcohol act.

Uniform alcohol act.


Blue Shield-Blue Cross loss of employment premium waiver.


The volunteer health agencies' role today and tomorrow.


Nineteen year-old Caucasian male with confusion after multiple fractures.


Mesothelial cyst presenting as an anterior superior mediastinal mass.


Hodgkin's disease terminating in acute leukemia.


Trauma in the emergency unit.

Trauma in the emergency unit.


Environmental problems and health.

Environmental problems and health.


Marijuana.

Marijuana.


Mass immunization campaigns--the successful and continuing approach.


Myocardial infarction in the presence of right bundle branch block.


An automatic case-history taker for eye examination.


Pregnancy and concurrent chronic myelogenous leukemia.


Photographic recording of the retinoscopic relfex.


Television retinoscopy--a new teaching and research tool.


The ophthalmetron, principles and operation.


A study involving glass safety lenses.

A study involving glass safety lenses.


The stereoscopic sense of order--a classification of stereograms.


The F-B cornea tonometer calibration device.


Bone marrow response to erythropoietin in polycythemia vera and chronic granulocytic leukemia.


Cell migration inhibition in human lymphomas using lymph node and cell line antigens.


Medical malpractice survey.

Medical malpractice survey.


Of medical ethics.

Of medical ethics.


Cryptococcosis and other pulmonary mycoses in Columbia.


Endosseous blade-vent implants: a research review.


Closed carotid artery hemorrhage as a complication of minor gunshot wounds of the face and jaws.


The effect of mandibular osteotomy on tongue position.


Sodium diphenylhydantoin association with oral healing.


Ludwig's angina: a complication of a bilateral mandibular fracture: report of case.


Adenoameloblastoma (odontogenic adenomatoid tumor): report of case.


Cardiac asystole after repeated administration of succinylcholine chloride: report of case.


Solitary tricheoepithelioma of the upper lip: report of case.


Osteopetrosis: report of a case.

Osteopetrosis: report of a case.


Is the radical mastectomy passé?

Is the radical mastectomy passé?


The morbidity of human ascariasis.

The morbidity of human ascariasis.


Pesticide morbidity in South Carolina, revisted.


Smallpox eradication.

Smallpox eradication.


Structure of Fab' New at 6 A resolution.


Melanin and cellular reactions to ultraviolet radiation.


Involvement of H-2 locus in a multigenically-determined immune response.


Specific alteration of the surface charge of immunocytes.


Effect of lithium on rearing activity in rats.


Nonmathematical models for evolution of altruism, and for group selection (peck order-territoriality-ant colony-dual-determinant model-tri-determinant model). Mathematical biologists have failed to produce a satisfactory general model for evolution of altruism, i.e., of behaviors by which "altruists" benefit other individuals but not themselves; kin selection does not seem to be a sufficient explanation of nonreciprocal altruism. Nonmathematical (but mathematically acceptable) models are now proposed for evolution of negative altruism in dual-determinant and of positive altruism in tri-determinant systems. Peck orders, territorial systems, and an ant society are analyzed as examples. In all models, evolution is primarily by individual selection, probably supplemented by group selection. Group selection is differential extinction of populations. It can act only on populations preformed by selection at the individual level, but can either cancel individual selective trends (effecting evolutionary homeostasis) or supplement them; its supplementary effect is probably increasingly important in the evolution of increasingly organized populations.


Transglutaminase from hair follicle of guinea pig (crosslinking-fibrin-glutamyllysine-isoenzymes-purified enzyme). Two transglutaminases are found in homogenates of the inner root sheaths of guinea pig hair-follicles. One is indistinguishable from the well-characterized liver transglutaminase [J. Biol. Chem., 246, 1093 (1971)]. The other, which is present in far greater quantity, has not been detected in other organs or tissues. Gel filtration and polyacrylamide gel electrophoresis studies indicate that the native hair-follicle enzyme, of molecular weight 54,000, is composed of two subunits of identical molecular weight. Specificity studies suggest that the intermolecular cross-linking of fibrin and fibrinogen that is catalyzed by this enzyme is a result of the formation of epsilon(gamma-glutamyl)lysine bonds. The probable participation of hair-follicle transglutaminase in the formation of these cross-links in the proteins of hair is discussed.


The sensitivity of developing cardiac myofibrils to cytochalasin-B (electron microscopy-polarized light-Z-bands-heartbeat). Developing cardiac muscle cells of 11- to 13-somite chick embryos are sensitive to cytochalasin-B. In cultured chick embryos, ranging in development from 11 to 13 somites, hearts stop beating in the presence of this agent. Both polarized light and electron microscopic examination show that cytochalasin-B disrupts existing myofibrils and inhibits the formation of new ones. Discrete Z-bands are not present in treated heart cells and thick, presumably myosin, filaments are found in disarray. These effects are reversible; after cytochalasin-B is removed from the medium, heartbeat recovers and myofibrils with discrete Z-bands reappear. Fibrillar sensitivity appears to be a function of age since fibrils in hearts of embryos having from 22 to 28 pairs of somites are more resistant.


How genetic background masks single-gene heterosis in Drosophila (polymorphism-selection-isoenzymes-inbreeding-fly). Conditional heterosis associated with two isoallelic forms of octanol dehydrogenase in Drosophila pseudoobscura has been detected in flies that have been (a) inbred for several generations to make the background genotype as homozygous as practicable, and (b) grown on a medium containing a small amount of octanol. The heterosis was first found in inbred males. The possibility that the effect in females was masked by X-linked polymorphic genes affecting the same fitness components as the locus for octanol dehydrogenase was shown to be correct when, on further inbreeding, heterosis was found in the females of one of the lines. The implications of this and other findings for the current understanding of the genetic structure of natural populations is discussed.


Isolation of the insulin receptor of liver and fat-cell membranes (detergent-solubilized-( 125 I)insulin-polyethylene glycol precipitation-sephadex). Extraction of liver and fat-cell membranes with the nonionic detergent Triton X-100 prevents specific binding of (125)I-labeled insulin to these membranes. This loss of binding to particulate material is quantitatively recovered in a high-speed (300,000 x g, 2 hr) supernatant of the extract. Specific and reversible insulin binding to soluble proteins is readily demonstrable by gel filtration. A simple and sensitive assay for detection of specific macromolecule-insulin complexes has been developed based on the selective precipitation of the complex by polyethylene glycol. Extraction of membrane lipids with organic solvents or by phospholipase digestion does not impair the subsequent extraction of the insulin-binding protein with detergent. Binding of insulin to the soluble protein is a saturable and dissociable process having a dissociation constant of about 100 nM. Derivatives of insulin compete for binding in direct proportion to their biological activity; other peptide hormones are without effect. The quantitative features of the detergent extractions and the specific insulin-binding properties of the material so obtained indicate that the protein solubilized is the biologically significant insulin receptor, whose insulin-binding function is essentially unaltered.


Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 . By use of human-mouse somatic cell hybrids, an autosomal gene linkage has been determined for the human loci controlling the phenotypes of lactate dehydrogenase-A (EC 1.1.1.27) and esterase-A(4) (EC 3.1.1.2). These structural loci were not linked to the lactate dehydrogenase-B, peptidase-B linkage, the X chromosome, the E(17) chromosome, or to nine other enzyme phenotypes examined.


A new micromethod for evaluating lymphocyte responses to phytohemagglutinin: quantitative analysis of the function of thymus-dependent cells. We have developed a new micromethod for testing phytohemagglutinin stimulation of human lymphocytes. 50 mul of peripheral blood is incubated at 37 degrees C directly, without cell separation, with 50 mul of tissue culture medium containing 50mug of phytohemagglutinin for 24 hr. Then, 0.5 muCi of tritiated thymidine in 50 mul of tissue culture medium is added and incubated for an additional 16 hr. After incubation, erythrocytes are selectively lysed in distilled water, and white blood cells are trapped quickly on a Millipore filter. The radioactivity of the filter is then assessed by a scintillation counter. The requirement of extremely small amounts of blood and a short incubation time are advantages. Further, this method provides a most useful evaluation of thymusdependent cell populations in man and experimental animals and, for the first time, this method provides the possibility of quantitating the deficiency of thymus-dependent cells.


Stimulation of DNA and protein synthesis in fetal-rat liver cells by serum from partially hepatectomized rats. Primary cultures of differentiated liver cells from fetal rats respond to serum from partially hepatectomized rats by an increased uptake of [(3)H]thymidine and [(3)H]leucine as compared with cultures incubated with normal rat serum. These findings are discussed in relation to the mechanism of induction of DNA synthesis and growth in liver cells during liver regeneration.


Detection of polyadenylic acid sequences in viral and eukaryotic RNA(polu(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4). A rapid and specific technique to detect polyriboadenylic acid sequences in RNA is described. The method depends upon the ability of RNAs that contain poly(A) sequences to associate specifically with poly(U) that has been immobilized on fiberglass filters by ultraviolet irradiation. A high proportion of the transcripts synthesized in vivo and in vitro from the vaccinia virus genome contain poly(A) sequences and bind to the poly(U) filters. Similarly, DNA-like RNA from the nucleus and from the cytoplasmic polyribosomes of HeLa cells is rich in species that bind to poly(U) filters. Poly(U) immobilized on cellulose powder is useful to make columns with a high capacity for the binding and purification of poly(A)-containing RNAs.


Evolution of neurophysin proteins: the partial sequence of bovine neurophysin-I (vasopressin-oxytocin-carrier proteins-automated amino-acid-sequence analysis-homology-protein evolution). The sequence of the first 50 amino-acid residues of bovine neurophysin-I was determined. A comparison of this sequence with that of the 97-residue bovine neurophysin-II and the 92-residue porcine neurophysin-I molecules reveals a high degree of homology among these proteins. It is suggested that the binding site of neurophysin proteins for neurohypophyseal hormones is located in the middle portion of these molecules, where their sequences are virtually identical. The sequence data, as well as the occurrence of at least two neurophysins in both the pig and the cow, suggest that each species inherited at least two structural genes controlling the synthesis of these proteins. The most striking finding in the study was the observation of internal sequence homologies within the neurophysins. This result implies that these molecules arose by way of a series of partial gene duplications of a primitive gene that coded for a smaller ancestral protein.


The mechanism of viral carcinogenesis by DNA mammalian viruses: RNA transcripts containing viral and highly reiterated cellular base sequences in adenovirus-transformed cells (DNA-RNA hybridization-viral-cell mRNA). Virus-specific RNA was isolated from cells transformed by human adenovirus 2 and 7 by multiple hybridizations with and elutions from homologous viral DNA; RNA molecules purified by this selection procedure hybridized efficiently with both viral DNA (24-50%) and DNA from untransformed cells (12-27%). Virus-specific RNA isolated in the same manner from cells productively infected with adenoviruses did not hybridize significantly with cellular DNA. These findings suggest that RNA molecules containing covalently-linked viral and cellular sequences are transcribed in cells transformed by human adenoviruses. The high efficiency of hybridization with DNA from untransformed cells implies that viral DNA is integrated adjacent to highly reiterated cellular DNA sequences.


Role of transcription in the temporal control of development in Caulobacter crescentus (stalk-rifampin-RNA synthesis-DNA synthesis-motility). The requirement for transcription during development of the stalked bacterium, Caulobacter crescentus, was studied with synchronous cultures of swarmer cells. The developmental pattern in these bacteria was first established by determination of the times at which specific changes in cell structure and function occurred. These changes could be divided into those characteristic of (a) development of the swarmer cell into the stalked cell: loss of motility and synthesis of the stalk, and (b) development of the stalked cell into the asymmetric dividing cell: chromosome replication, synthesis of the flagellum, motility, and division. The effect of rifampin in blocking several of these steps-loss of motility, initiation of chromosome replication, and cell division-indicates that RNA synthesis is required throughout the cell cycle for normal differentiation.


A new synthetic RNA-dependent DNA polymerase from human tissue culture cells (HeLa-fibroblast-synthetic oligonucleotides-template-purified enzymes). Two DNA polymerases that can copy synthetic RNA polymers are present in human tissue culture cells. These enzymes which have each been purified about 500-fold, are present in both HeLa cells, which are derived from a cervical carcinoma, and in WI-38 cells, a normal diploid strain originating from human embryonic lung tissue. These synthetic RNA-dependent DNA polymerases are identified by their ability to copy efficiently the ribo strand of synthetic oligonucleotide-homopolymer complexes, and differ in this respect from the known DNA-dependent DNA polymerases found in HeLa cells. The template requirements of these new DNA polymerases resemble that of the RNA-dependent DNA polymerases of the RNA tumor-viruses.


Calcium ions and the cardiotonic action of glucagon (calcium fluxes-myocardial function-asystole-membrane transport-cat). The positive inotropic action of glucagon on the cat heart is dependent upon the extracellular Ca concentration. The inotropic effect is proportionately greater, the lower the concentration of Ca in the perfusate (above zero, at which glucagon is without significant effect). Nevertheless, Ca influx (as measured with (45)Ca) into the myocardium is not demonstrably influenced by glucagon, except at 0.09 mM Ca, where the interpretation of the effect is complicated by the fact that there is mechanical asystole at that Ca concentration in the absence of glucagon, while excitation-contraction coupling still occurs when the hormone is added. The possibility is suggested that glucagon may influence intracellular movement of Ca, even when its transmembrane movement is affected only slightly.


Membrane microfilaments of erythrocytes: alteration in intact cells reproduces the hereditary spherocytosis syndrome (vinblastine-colchicine-strychnine-electron microscopy-cell rigidity). Membrane microfilaments are found throughout the animal world in situations suggesting that they fulfill a critical role in providing normal cell shape and plasticity. We have hypothesized that hereditary spherocytosis, a congenital hemolytic anemia associated with intrinsically rigid and mishapen erythrocytes, might result from genetically defective microfilaments in erythrocyte membranes. By using three different drugs (vinblastine, colchicine, and strychnine) that share one common attribute-that of potently precipitating purified microfilamentous protein-we have provided support for this hypothesis. Thus, all the known in vitro and in vivo characteristics of hereditary spherocytes are reproduced in normal erythrocytes briefly exposed to these precipitating agents.


Intercellular contact and cell-surface galactosyl transferase activity (cell culture-mouse-radioautography-contact inhibition-cis-and trans-galactosylation). Evidence is presented suggesting the presence of galactosyl transferases and galactosyl acceptors on the outer surfaces of intact Balb/c 3T3 cells. In addition, the data indicate that these transferases may only be capable of transferring galactose from uridine diphosphate galactose to galactosyl acceptors on adjacent cells after intercellular contact is made (trans-glycosylation). Intact Balb/c 3T12 cells, by contrast, show no requirement for intercellular contact in order to carry out this reaction suggesting that these cells, which do not exhibit contact inhibition of growth, may be able to transfer galactose to acceptors situated on the same cell as the enzyme (cis-glycosylation). Electrophoretic and radioautographic assays were used to detect surface transferase activities in these two cell lines. Results of experiments on cells from sparse and dense cultures, and under conditions where intercellular contact was regulated, are consistent with the above hypothesis.


Parasexual recombination in Dictyostelium discoideum: selection of stable diploid heterozygotes and stable haploid segregants (clones-temperature sensitive-ploidy-fruiting bodies-spore-slime mold). Haploid strains of Dictyostelium discoideum bearing temperature-sensitive mutations have been used to select stable diploid, heterozygotic clones, which arise at low frequency (about 10(-5)). Segregants arise from such diploids at low frequency (about 10(-3)). The diploids were heterozygous for resistance to cycloheximide and were phenotypically sensitive to the drug. Growth of the diploid cells in the presence of cycloheximide automatically selected those segregants bearing the resistant allele, and facilitated examination of the assortment of unselected markers. The combination of the two selective methods provides a workable system of genetic analysis in this species. We have used this method to locate six markers on three different linkage groups.


Epinephrine binding to the catecholamine receptor and activation of the adenylate cyclase in erythrocyte membranes (hormone receptor- -adrenergic receptor-cyclic AMP-turkey). Turkey erythrocyte membranes showed specific binding of [(3)H]epinephrine. The concentration of hormone required for half-maximal binding (30 muM) was the same as that required for half-maximal activation of the adenylate cyclase located in the same membrane preparation. The binding reaction at 37 degrees C reached completion during the first minute of incubation, which agrees well with the known rapidity of the biological response to catecholamines. Specific binding was abolished by heating the membranes 1 min at 100 degrees C. Chromatography of the bound (3)H, after its extraction from the membranes, indicated that the hormone had fully retained its chemical structure. Epinephrine binding was inhibited by the beta-adrenergic blocking agent propranolol, which also inhibited the activation of adenylate cyclase by the hormone. The specificity of phenethylamine derivatives in displacing [(3)H]epinephrine from the binding sites showed that a typical catecholamine receptor was responsible for the binding. Displacement of the bound hormone by analogs lacking the catechol group was more extensive at 37 degrees C than at 0 degrees C. Some of the analogs that displaced epinephrine from the binding site caused only a feeble activation of the adenylate cyclase, but were able to inhibit the activation of the enzyme by epinephrine. Thus, binding to a catecholamine receptor on a membrane preparation is an essential, but insufficient, condition to elicit a response.


Acute promyelocytic leukaemia: a report of five cases with a comment on the diagnostic significance of serum vitamin B 12  determination.


Color, light, and shade matching.

Color, light, and shade matching.


The tapered dowel pin as a post and core.


Coefficient of friction of prosthetic tooth materials.


Evaluation of improved maxillofacial prosthetic materials.


Legal hazards of maxillofacial prosthetics.


Effect of root implants on resorption of residual ridges.


Guidelines for evaluation of completed prosthodontic treatment for complete dentures. Federation of Prosthodontic Organizations.


Guidelines for evaluation of completed prosthodontic treatment for removable partial dentures. Federation of Prosthodontic Organizations.


Sterilization of osteosarcoma in the dog (a case report).


Effects of alloxan diabetes on hypothalamic hyperphagia and obesity.


Acute oliguric renal failure associated with low-molecular-weight dextran.


Tracheostomy in thermally injured patients: a review of five years' experience.


Necrosis of the anterior maxilla following osteotomy.


The association of cleft palate with the Klippel-Feil syndrome.


Fracture of the mandible in a 5-month-old infant.


Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia.


Epidemiologic aspects of recurrent aphthous ulcerations.


Aphthous lesions.

Aphthous lesions.


Minor orofacial abnormalities in an Eskimo population.


Endodontic success--who's reading the radiograph?


Scar tissue associated with the apices of pulpless teeth prior to endodontic therapy.


The dental prognosis for xeroradiography.


Elongation of the styloid process.

Elongation of the styloid process.


The effect of  -chymotrypsin on wound healing in hamsters.


Use of computers in orthodontic analysis and diagnosis: a symposium. Introduction.


A new approach to the analysis of craniofacial morphology and growth.


The role of computers in dentofacial research and the development of diagnostic aids.


Computerized analysis of occlusion in the postcanine dentition.


Loop systems--a contemporary reassessment.


Malocclusion indices: a comparative evaluation.


A cephalometric appraisal of the Chinese (Cantonese).


Presidential address at AAO annual session in New Orleans.


The case for the panel discussion at the Denver meeting.


A radiographic cephalometric appraisal of the proportional relationship of the molar and incisor heights in hypodivergent, hyperdivergent, and normal patients.


AAO constituent society presidents consider orthodontic health proposals. II.


5'-terminal nucleotide sequence of reovirus mRNA synthesized in vitro.


Dissociation of oxyhaemoglobin, methaemoglobin and their hybrid compared by difference gel chromatography.


Foetal and maternal RNA labelled with  3 H-cytidine.


Rhodopsin is the predominant protein of rod outer segment membranes.


Nomenclature for isolated chloroplasts.

Nomenclature for isolated chloroplasts.


Movement of abscisic acid in Phaseolus vulgaris plants.


Bursa of fabricius as site of origin of germinal centre cells.


Synaptogenesis in the chick embryo spinal cord.


Isolation of duck haemoglobin messenger RNA and its translation by rabbit reticulocyte cell free system.


C-type virus associated with gibbon lymphosarcoma.


Synthesis of  -D-glucose 1,6-diphosphate in potentially prebiotic conditions.


Serum binding of calcium and the red cell membrane in cystic fibrosis.


Cytotoxic effects of peritoneal neutrophils on a syngeneic rat tumour.


Receptor for antibody-antigen complexes used to separate T cells from B cells.


Base composition of normal and megaloblastic bone marrow DNA.


Shock lung.

Shock lung.


Early oral orthopedics in cleft palate patients and the functional matrix.


The d.a.--that critical first impression.


Left wings, right wings, chicken wings.

Left wings, right wings, chicken wings.


Heads north--tails south.

Heads north--tails south.


Acute leukemia long-term survival.

Acute leukemia long-term survival.


Cardiac lymphatic involvement by metastatic tumor.


The rumble.

The rumble.


Degeneration of the pineal gland of patients with cancer.


Facts about fluorides for the dental auxiliary.


The orthodontic assistant--present and future.


University of Pacific adopts 3-year dentistry curriculum.


Find your hidden beauty.

Find your hidden beauty.


The interface of dental assisting and dentistry 1887-1987.


Disciplined listening--an approach in communication.


An overview of tooth morphology.

An overview of tooth morphology.


Series on plaque control instruction for the dental team. V. Plaque removal techniques.


Practice administration.

Practice administration.


Role of the Council on Dental Education in dental assisting education.


8 reasons why your patients won't be back. A survey of dental dropouts.


The dollars and sense of selling a practice.


The State Board controversy.

The State Board controversy.


Think of it as money, doctor.

Think of it as money, doctor.


Look before you leap. Real estate syndication.


Punch your assistant in?

Punch your assistant in?


Your malpractice policy: pass or fail?

Your malpractice policy: pass or fail?


Increase your deductibles.

Increase your deductibles.


Mutual funds: does past performance pay off?


Dear Juli: good health and good grooming.


How does your net worth grow?

How does your net worth grow?


The 3-year curriculum breaks through.

The 3-year curriculum breaks through.


Pass-fail gets an agonizing reappraisal.


Draft picture 72: unlikely but don't bet on it.


Student participation in school committees is here to stay.


Washington brings dentists to the people.


Student action helps put AADE's Character-Reference program into limbo.


Formocresol pulp therapy.

Formocresol pulp therapy.


'Dental bird-watching' for greater prevention.


Case reports--treatment of radicular cysts.


A simplified cast pin technic.

A simplified cast pin technic.


Technic for removal of temporary crowns.


Community dental care: communication is the key.


Top priority in research: prevention.

Top priority in research: prevention.


Acupuncture and the delivery of health care in Red China.


Case report--dental treatment after maxillectomy.


Modern offices. Color scheme promotes youthful relaxation.


Dental auxiliary utilization and training.


Pharmacy and dentistry.

Pharmacy and dentistry.


Treatment of root surfaces with a combination of acidulated phosphofluoride and stannous fluoride.


A clinical study of local anesthesia productions by jet injection.


Diagnosing patient eligibility for occlusal equilibration.


Dental study clubs.

Dental study clubs.


General dentistry: where it is and where it is going.


Denture base reliners: two techniques.

Denture base reliners: two techniques.


The dentist as cinematographer.

The dentist as cinematographer.


Rationale for orthodontic treatment in the primary and mixed dentitions.


Modifications for successful use of silver points in endodontics.


Leasing dental equipment-caveat emptor. (Let the buyer(lessee)beeware).


Intravenous amnesia-sedation technique for the ambulatory patient.


Our periodontal condition is not what we eat.


Dental hygiene--expansion or extinction?


A possible relationship between desquamation and dentifrices. A clinical study.


Expanded duties for dental auxiliaries--a challenge for change in the seventies.


The role of dental auxiliaries in continuing education.


Gel electrophoresis of intracellular components of some cariogenic streptococci.


A plea for clarity in writing.

A plea for clarity in writing.


Periapical tissue response to the apical plug in root canal treatment.


A method of introducing preclinical students to scaling with the use of large scale models.


Thermal fatigue in teeth.

Thermal fatigue in teeth.


Exfoliation of the deciduous teeth during the ages of mixed dentition.


Tertiary aromatic amine accelerators with molecular weights above 400.


Heterogeneity of peroxidase related to antibacterial activity in human parotid saliva.


Observations on the implantation and transmission of Streptococcus mutans in humans.


Shot impact test for dental amalgam.

Shot impact test for dental amalgam.


Thermogravimetric analysis of dentin.

Thermogravimetric analysis of dentin.


Use of mathematical models in the study of structure-toxicity relationships of dental compounds. I. Esters of acrylic and methacrylic acids.


Effect of pulsating water jet lavage on radioactive contaminated wounds.


Comparison of the caries-producing properties of diets 2700, 2000, and modifications of 2000 in rats.


Comparison of jet injection and needle-syringe injection techniques in production of edema.


An alteration in human diabetic arterioles.


Optical sectioning of oral exfoliated cells.


Mercury vapor emission from dental amalgam.


Fluoride concentrations in deciduous tooth enamel of children chewing sodium fluoride tablets.


Activation of medullary neurons by noxious stimuli applied to the teeth.


Interference between gram-positive microorganisms in dental plaque.


Human mixed saliva protein concentration.


The effect of age and strain differences on the incidence of restraint-induced oral and gastric ulcers in three strains of rats.


Wear of fluorapatite single crystals. II. Frictional behavior.


Your oral pathology service 1962-1970. II. Oral cancer in Kentucky.


Influence of dietary sucrose concentration on the cariostatic properties of NaH2PO4 in the rat.


Electrostatic precipitation as a means of reducing airborne microorganisms in dental operating rooms.


Idiopathic resorption.

Idiopathic resorption.


Toothbrush disease.

Toothbrush disease.


Metabolism of alkali-soluble and alkali-insoluble polysaccharides of dental plaque.


Fissure sealants: an overview.

Fissure sealants: an overview.


Relative titratable acidity from potato starch, maltose, sucrose, and glucose produced by saliva.


Fluoride reduction by home water softeners.


Professionalism...what it means to me.

Professionalism...what it means to me.


Uptake of tritiated glucosamine by the femur and mandible of 7-day-old and adult mice.


Lack of relationship between the degree of induced gingival hyperplasia and the concentration of diphenylhydantoin in various tissues of ferrets.


Versatility of maxillary surgery in the correction of malocclusion.


Nitrous oxide.

Nitrous oxide.


MDA insurance questionnaire survey...synopsis, recommendation.


Effect of radiation on bone.

Effect of radiation on bone.


Improved technique for sectioning the inferior alveolar nerve in rats.


Ultrastructure of intradentinal nerves after resection of the inferior alveolar nerve in mice.


Trends and projections in dental education.


Prepaid dental health care systems.

Prepaid dental health care systems.


Application of replica techniques for use with scanning electron microscopes in dental research.


Quantitative determination of eugenol in powder supplied with a zinc oxide-eugenol cement.


Dimensional change instrument for amalgam.


The lowering of specialty and research interests among dental students.


Recruiting minority group students for the health professions.


Effect of maltose on polysaccharide synthesis by a cariogenic streptococcus.


Incidence of primary O rugae in Bushman juveniles.


Law and economics of dental practice.

Law and economics of dental practice.


Secretory potentials in the cat parotid gland in response to methacholine chloride.


Expanding dental health services through auxiliaries.


Awards offered by the IADR.

Awards offered by the IADR.


Sealing of developmental pits and fissures. IV. Measurement of in vivo fluoride pickup by electron microprobe x-ray spectrophotometry.


Dental hygienists in Wisconsin, 1970.

Dental hygienists in Wisconsin, 1970.


Complete dentures--three point balance.

Complete dentures--three point balance.


Dental technicians should write.

Dental technicians should write.


Activation of T and B lymphocytes by insoluble phytomitogens.


Distinct transcription products of ribosomal genes in two different tissues.


Role of penultimate tyrosine in haemoglobin   subunit.


Effects of yeast killer factor on sensitive cells.


Inhibition of RNA polymerase by streptolydigin.


Acceptances to the New Jersey dental school: a comparison of men and women dental aptitude scores.


Why organized dentistry.

Why organized dentistry.


The irony of our progress: a dental essay.


Toxicity of the taste testing compound phenylthiocarbamide.


A review of the treatment of traumatized anterior teeth.


Selective defect in insulin release in one form of spontaneous laboratory diabetes.


Effects of gonadotrophins on motility of human ovary.


Restoration of protein synthesis after death and the effect of postmortal cooling.


Expanded duties: what and why.

Expanded duties: what and why.


Electrosurgery as an aid to crown and bridge procedures.


Fear: a psychological and a dental problem.


A new dimension for the profession and the dental laboratories.


Student research. Preparation for practice.


Studies on the nerve endings in human hearts.


Aspects of galactose metabolism in normal and galactosemic cell cultures.


On prescribing tranquilizers.

On prescribing tranquilizers.


The doctor as an employee. Some advantages and disadvantages.


Late-onset epilepsy.

Late-onset epilepsy.


The psychiatric intensive care unit.

The psychiatric intensive care unit.


Hyponatremia in association with vincristine therapy.


Management of acute renal failure due to marked hyperuricemia.


Surgical resection of aneurysm of the abdominal aorta: experience with 137 consecutive cases. Elective operation improves survival expectancy significantly.


Managing Class 1 open bites. A myofunctional approach.


Ossified stylohyoid ligament (epihyal bone): an unusual case.


Dryness of the mouth (xerostomia): analysis and case report.


Teeth impacted by trauma.

Teeth impacted by trauma.


Cephalosporins. 2.

Cephalosporins. 2.


Infiltrative lesion of the bladder presenting as gross hematuria in child with leukemia: case report.


Non-reactive tuberculosis and malignant blood disorders.


Internal mammary artery implantation. Experience in community hospital.


Detection of narcotic, sedative, and amphetamine drugs in urine. Use of ion-exchange paper extraction.


External traction for depressed facial fractures.


Aspergilloma of sinus.

Aspergilloma of sinus.


Hyperosmolar diabetic state with sickle thalassemia.


Thrombocytopenia associated with rubella vaccination.


What to do until the ambulance comes. Phase I of community emergency care program.


Pin retained crown restoration: an original approach.


Electrosurgical correction of maxillary double lip.


X-rays play key role in search for lost Egyptian rulers.


A case of undiagnosed syphilis presenting with glossitis.


Unusual periodontal abscess.

Unusual periodontal abscess.


Irradiation and the developing teeth.

Irradiation and the developing teeth.


Review of phenol.

Review of phenol.


Health Education Centers.

Health Education Centers.


Health Maintenance Organizations.

Health Maintenance Organizations.


Educational objectives and the determination of the cost and length of health professional education.


A new approach to teaching with models.

A new approach to teaching with models.


Psychological processes and their impact on human behavior: an essential body of knowledge for the dental curriculum.


Self-instructional, preclinical fixed partial prosthodontics.


A conjoint course in growth and development for the dental student.


A comparative cost analysis of dental students' instruments and textbooks.


France makes major changes in law governing dental profession.


Peer evaluation of fixed partial dentures in a preclinical course.


WHO drops term "paramedical" as applying to dental profession.


Therapist training curriculum, University of Alabama in Birmingham.


An integrated course in human disease.

An integrated course in human disease.


Successful management of patients with cardiac valvular prosthesis.


Lip incompetency and its treatment.

Lip incompetency and its treatment.


Guidelines for establishing dental programs in nursing homes.


Condominium: as an apartment, O.K. For an office, better yet.


The peer review committee.

The peer review committee.


Reflections on a workshop.

Reflections on a workshop.


Dissociation of erythroblastic and myeloblastic proliferation in erythroleukemia.


Temporomandibular joint dysfunction.

Temporomandibular joint dysfunction.


A plea to use simple language in scientific writing.


Psychodynamics for the hypnodontist.

Psychodynamics for the hypnodontist.


The use of hypnosis in female sexual anesthesia.


Osteogenic sarcoma in a 9-month-old dog.


Structural localization of lysosomal enzymes in gingival sulcus cells.


Enzymes and antienzymes in inflammatory reactions.


Enzymes and general biology: special reference to enzyme synthesis, purification, and reactions on matrixes.


Role of cathepsins in granulation tissue.


Enzymic properties of human dental plaque proline iminopeptidases adsorbed on hydroxylapatite.


Variations in histochemical properties of hydrolytic enzymes in oral precancerous conditions.


Effects of local applications of microencapsulated catalase on the response of oral lesions to hydrogen peroxide in acatalasemia.


Lithium--its practical usage in psychiatry.


Incus interposition--a new technique.

Incus interposition--a new technique.


A follow-up study on tuboplasties.

A follow-up study on tuboplasties.


Extracorporeal circulation.

Extracorporeal circulation.


Histochemical observations of hypophosphatasia.


Inhibitory actions of calcitonin on resorbing bone explants in culture and on their release of lysosomal hydrolases.


Hemodynamic effects of cardiac arrhythmias.


Anemia, briefly discussed.

Anemia, briefly discussed.


Traumatic coronary arterial-right ventricular fistula. Report of a case.


The future of private medicine.

The future of private medicine.


The case of the defrocked nurse.

The case of the defrocked nurse.


Beta-glucuronidase and periodontal destruction.


Substrate film techniques for the histochemical demonstration of amylase and protease in salivary glands.


Post-traumatic pulmonary insufficiency: a physiologic basis for treatment.


Some properties of a dextranglucosidase isolated from oral streptococci and its use in studies on dextran synthesis.


Enzyme dynamics of a cariogenic streptococcus: the effect of xylitol and sorbitol.


Purification and properties of an alpha-(1-3) glucanohydrolase from Trichoderma harzianum.


Proteolytic activity in the oral cavity: proteolytic enzymes from human saliva and dental plaque material.


The placenta--an overlooked organ.

The placenta--an overlooked organ.


Immunization with dextransucrases and glycosidic hydrolases.


Studies on the fate of the glucosyl moiety of sucrose metabolized by Streptococcus mutans.


The geriatric patient and the nursing home.


Parameters that effect the adherence of Streptococcus salivarius to oral epithelial surfaces.


Visual acuity after surgery for retinal detachment.


A simple inspiratory safety valve.

A simple inspiratory safety valve.


The role of the respirator in the management of patients after cardiac surgery.


Respiratory care in infants and children.


The pre-employment examination: an evaluation.


Massive pleural effusion: malignant and nonmalignant causes in 46 patients.


Ozone air pollutants and lung damage.

Ozone air pollutants and lung damage.


Storage of organochlorine insecticides in people of Sao Paulo, Brazil.


The early diagnosis of asymptomatic liver diseases within an occupational health programme.


Patient specific test selection in multiphasic health testing.


Combination therapy.

Combination therapy.


The promise and problems of community mental health centers.


The prevention of death after injuries.

The prevention of death after injuries.


Megaloblastic anemia resulting from starvation diet.


Acute transmural myocardial infarction. Course of illness following discharge from a coronary care unit.


Primary sarcoma of the breast.

Primary sarcoma of the breast.


Surgical approach to the treatment of melanoma.


How to get the most out of medical meetings.


Nodular fasciitis.

Nodular fasciitis.


The use of visual evoked responses in objective refraction.


The effects of interferon and its inducers on experimental protozoan parasitic infections.


The effect of L-asparaginase on the nucleic acid metabolism and cell cycle of human leukemia cells.


Granulocyte collection by continuous-flow filtration leukapheresis.


Structure of horse-muscle phosphoglycerate kinase at 6 angstrom resolution.


RNA double helix and the evolution of the 3',5' linkage.


Effects of prostaglandins F 2  , E 2  and E 1  on fertility in mice.


Synthesis of haemoglobin Lepore.

Synthesis of haemoglobin Lepore.


Possible autoimmune processes related to chromosomal abnormalities (breakage) in NZB mice.


Enhanced resistance of mice to infection with bacteria following pre-treatment with Corynebacterium parvum.


Failure of cytochalasin or colchicine to inhibit secretion of immunoglobulins.


Adverse experience with stainless steel spring intrauterine device.


Intraoperative management of fluid deficits.


Health information system. One coordinator of health care for communities.


Multiphasic health screening at an urban hospital. Technologic considerations.


Health data network for western New York area. Role of Erie County Medical Society in its establishment.


Health data network for western New York area. Operation of network.


PseudoMeigs syndrome. Associated with metastatic cancer of ovary.


Ureterocele and ureteral duplication, associated congenital malformations.


Scopolamine intoxication from nonprescription sleeping pill.


Subcapsular hematoma of spleen.

Subcapsular hematoma of spleen.


Prevention of cervix cancer deaths through hospital screening.


Intermittent vertebral arteriovenous fistula, due to cervical stab wound.


Peritoneal dialysis in acute uric acid nephropathy.


Human placental 15-hydroxyprostaglandin dehydrogenase. Normal, term, human placentas are a rich source of a 15-hydroxyprostaglandin dehydrogenase. The enzyme is extremely labile, and partial purification could be achieved only after stabilization with glycerol. The instability of the enzyme and its K(m) for NAD are indications that it is different from the 15-hydroxyprostaglandin dehydrogenase isolated from swine lung. Human placental tissue should provide a very useful source from which large amounts of highly purified 15-hydroxyprostaglandin dehydrogenase may be obtained.


Photoelectron microscopy: a new approach to mapping organic and biological surfaces. A general method of imaging organic and biological surfaces based on the photoelectric effect is reported. For the experiments, a photoelectron emission microscope was constructed. It is an ultrahigh vacuum instrument using electrostatic electron lenses, microchannel plate image intensifier, cold stage, hydrogen excitation source, and magnesium fluoride optics. The organic surfaces examined were grid patterns of acridine orange, fluorescein, and benzo(a)pyrene on a Butvar surface. A biological sample, sectioned rat epididymis, was also imaged by the new photoelectron microscope. Good contrast was obtained in these initial low magnification experiments. These data demonstrate the feasibility of mapping biological surfaces according to differences in ionization potentials of exposed molecules. A number of technical difficulties, such as the intensity of the excitation source, must be solved before high resolution experiments are practical. However, it is probable that this approach can be useful, even at low magnifications, in determination of the properties of organic and biological surfaces.


Structure of a calcium-binding carp myogen. The amino-acid sequence and three-dimensional structure of a calcium-binding protein prepared from carp muscle has been determined. This protein, designated carp-muscle calcium-binding protein B, is one of three closely related parvalbumins found in this tissue. The electron density map, calculated by heavyatom substitution crystallographic methods to 2.0-A resolution, reveals the orientation of most of the amino-acid side chains. The calcium coordination site consists of one glutamic- and three aspartic-acid carboxyl groups in a tetrahedral arrangement. The core of this spherical molecule is remarkably hydrophobic, with 8 of its 10 phenylalanine side chains packed in an approximate herringbone pattern. 52 of the 108 residues are in six alpha-helixes; there is no beta-pleated sheet. The acetylated amino-terminal alanine appears not to be accessible to solvent. All of the heavy-atom derivatives are bound at the sole cysteine. The properties of this protein suggest a relationship to troponin A of mammalian tissue.


Magnetic resonance studies on membrane and model membrane system: proton magnetic relaxation rates in sonicated lecithin dispersions. We have used Fourier transform nuclear magnetic resonance methods to measure the spin-lattice and transverse relaxation times at 220 MHz of the choline N-methyl and the fatty-acid alpha-carbonyl, allyl, vinyl, methylene, and methyl protons of sonicated egg-yolk lecithin. Over the temperature range investigated the T(1) values were, in general, similar to, but different from, one another, suggesting that the relaxation rates of all of the fatty-acid protons are not determined solely by spin-diffusion to a heat sink. Arrhenius plots of the T(1) data gave activation energies similar to those for the barriers to internal rotation in alkanes. The values of the transverse relaxation rate, T(2), showed a relatively large variation among the proton resonances; about 20% of the methylene protons had a T(2) of 56 msec, while the remaining protons relaxed according to a distribution of values all shorter than 20 msec. Such a distribution of relaxation times is envisioned to arise from a distribution of correlation times stemming from complex motions in which extended angular excursions of the fatty acid chain are coupled to trans-->gauche conformational transitions.


Proton nuclear magnetic resonance studies of ribonuclease A in H 2 O. A resonance (designated a) due to an exchangeable proton titrates (pK(a) = 6.1) between 11.5 and 13 ppm in the nuclear magnetic resonance spectrum of RNase A-0.2 M NaCl in H(2)O at 20 degrees . Comparison with models has permitted assignment to a ring-nitrogen proton of histidine in slow exchange with solvent H(2)O. The pH and temperature-dependent line-width changes of resonance a are analyzed in terms of an exchange between histidine and protonated histidine, without the necessity to invoke any exchange processes associated with protein conformational changes. Several other resonances due to exchangeable protons are observed between 10 and 15 ppm in the nuclear magnetic resonance spectrum of RNase A in H(2)O.


Regeneration and changes in synaptic connections between individual nerve cells in the central nervous system of the leech. The central nervous system of the leech has been used for the study of the formation of new synaptic connections by regenerating neurons. In control leeches, individual nerve cells in adjacent ganglia are connected in an orderly and stereotyped manner, with only little variation. In the present experiments, a bundle of axons running between two of the segmental ganglia has been severed and allowed to regenerate. Subsequently, the axons reestablish synaptic connections between certain identified nerve cells in the adjacent ganglia, selectively and accurately. Thus, individual sensory cells in one ganglion show a high degree of neural specificity in reestablishing cell to cell connections with a motor cell in the next ganglion. The performance of the regenerated synapses, however, is significantly altered in a consistent manner. The normal balance between the effects of inhibitory and excitatory innervation in leeches with regenerated synapses is different from that seen in normal leeches, with marked overemphasis on inhibition. Similar alterations have also been seen in a series of ganglia at a distance from the site of the lesion. After the operation, therefore, a widespread modification of synapses occurs along the length of the nerve cord.


Barbiturate interaction with phosphatidylcholine. A hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates. The nitrogenbound proton of the barbiturate and the orthophosphate moiety of the phosphatidylcholine molecule appear to be involved. The more pronounced effect with the two barbiturates occurs in the proton magnetic resonance spectra of phenobarbital with increased amounts of phosphatidylcholine. A plot of the chemical shift of phenobarbital N-H against the concentration of phosphatidylcholine is linear and gives an extrapolated shift of 260 Hz (2.6 ppm) at 35 degrees C for a phosphatidylcholine-phenobarbital ratio of unity, pure 1:1 complex. It is suggested that the general depressant nature of barbiturates may be accounted for by their association in a similar fashion with a number of other phosphate-containing molecules.