Behavior of Mycobacterium leprae in human macrophages in vitro. Attempts have been made to cultivate Mycobacterium leprae in human macrophages in vitro. In 27 out of 55 experiments a two- to ninefold increase (mean 2.31 +/- 1.46) in acid-fast organisms were observed over a period of 1.5 to 3 months of cultivation. No such increase was observed with heat-killed bacilli (mean fold increase 0.88 +/- 0.19). Macrophages were necessary for obtaining increases. No multiplication was observed on artificial media. A close correlation between increases of acid-fast organisms and changes in viability as determined by the morphology of the bacilli (morphologic index) was found. The increases in acid-fast organisms could be inhibited by anti-leprosy drugs. It is concluded that multiplication of M. leprae may take place inside human macrophages in vitro. Multiplication appears not to be dependent on whether the macrophages are derived from lepromatous or tuberculoid patients or healthy individuals. Moreover, multiplication took place both at 33 and 37 C. The applicability of this method is at present limited by the restricted survival of human macrophages in vitro.


Susceptibility of guinea pig cell cultures to infection with cell-bound and cell-free herpesvirus of turkeys. Cell-bound and cell-free herpesvirus of turkeys infected and replicated in guinea pig cell cultures as evidenced by cytopathic effects, intranuclear inclusions, and the presence of herpesvirus particles as seen by electron microscopy were studied in this investigation. Further evidence for the replication of herpesvirus of turkeys in cell cultures was determined by serum neutralization, complement fixation, and the fluorescent antibody tests.


Intermediate cells of the pancreas. II. The effects of dietary soybean trypsin inhibitor on acinar-beta cell structure and function in the rat.


Granulocyte-macrophage precursor cell and colony-stimulating factor responses of mice infected with Salmonella typhimurium. The response of granulocyte-macrophage progenitor cells (in vitro colony-forming cells) and of colony-stimulating (CS) factor in serum were studied in mice infected intraperitoneally with 10(3) viable Salmonella typhimurium. Increases in the number of colony-forming cells in marrow and spleen and increases in the serum level of CS factor occurred during the infection. There was no evidence to suggest that progressive infection was associated with failure of macrophage production. Medium rich in CS factor increased the bactericidal activity of macrophages in vitro and it was suggested that CS factor could be involved in macrophage activation.


Benzathine penicillin in the prophylaxis of streptococcal skin infections: a pilot study.


Ad libitum oral glucose-electrolyte therapy for acute diarrhea in Apache children. This report describes the authors' experiences among Apache Indians who required rehydration therapy because of acute diarrhea.  About 400 children, aged less than 2 years, who were strong enough to drink, were given oral glucose-electrolyte solutions.  The solution contained, in millimoles per liter, sodium (81), potassium (18), chloride (71), bicarbonate (28), and glucost (139).  The cost of the formula is 2.5 cents per liter.  In children with a 2 degree volume depletion, more of the solution was required (statistically significant) than if the child suffered 1 degree volume depletion; however, 9 of 11 children with 2 degree depletion were adequately hydrated 3-6 hours after administration.  Moderate electrolyte abnormalities, which included hypo- and hypernatremia and acidosis, were corrected or improved during the administration of the oral rehydration therapy.  Plasma potassium concentrations showed little change.  The oral therapy failed in 2 children due to malabsorbed glucose, but both were successfully treated with intravenous fluids, a carbohydrate-free formula, and broad-spectrum antibiotics.  The ad libitum sue of oral therapy is effective and should help reduce infant mortality and morbidity due to diarrhea.


Temporary treatment of hydrocephalus and myelodysplasia with isosorbide: preliminary report.


Dermatomyositis.

Dermatomyositis.


Current concepts of the action of androgenic steroids on erythropoiesis.


The T-N-PR model of radiation response.

The T-N-PR model of radiation response.


Charles Bickerton Blackburn.

Charles Bickerton Blackburn.


Radioassay of the calciotropic hormones.


How radioimmunoassay has added to our knowledge about gastrin.


Application of competitive ligand binding for the radioassay of vitamin B12 and folic acid.


Physiologic implications of prostaglandin radioimmunoassay.


Solomon A. Berson Memorial Service.

Solomon A. Berson Memorial Service.


Radioimmunoassay and competitive binding radioassay methods for the measurement of drugs.


Radioimmunoassay of glucagon.

Radioimmunoassay of glucagon.


The aortocranial vessels. The transfemoral approach. Analysis of results and complications.


Further results of stereotaxis in the human hypothalamus in sexual deviations. First use of this operation in addiction to drugs.


Application of radioreceptor assay to circulating insulin, growth hormone, and to their tissue receptors in animals and man.


Bioavailability of digoxin tablets.

Bioavailability of digoxin tablets.


Reversal of the pharmacological and toxic effects of cardiac glycosides by specific antibodies.


Antibodies to morphine, barbiturates, and serotonin.


Principles and methods for the preparation of drug protein conjugates for immunological studies.


Antibodies to pharmacologically active molecules: specificities and some applications of antiprostaglandins.


The immunotherapy of cancer.

The immunotherapy of cancer.


Glucodynamic hormones modify the recovery period after lateral hypothalamic lesions. The period of recovery after bilateral electrolytic lesions of the lateral hypothalamus in rats is shortened if insulin is given for 5 days before surgery, and is lengthened if glucagon is given during the preoperative period.


Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines. A variety of mammalian and avian tissues N- and O-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.


The effect of intravenously administered albumin on dogs with pulmonary interstitial edema.


Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Despite excessive glucagon responses to infusion of arginine, plasma glucagon did not rise in six juvenile-type diabetics during severe insulin-induced hypoglycemia, whereas glucagon in the controls rose significantly. Thus in diabetics pancreatic alpha cells are insensitive to glucose even in the presence of large amounts of circulating insulin. An intrinsic defect common to both alpha and beta pancreatic cells-failure to recognize (or respond to) plasma glucose fluctuations-may be operative in juvenile diabetes.


Patterns of injury requiring pancreatoduodenectomy.


A new surgical suture technique.

A new surgical suture technique.


Ex vivo perfusion, arteriography, and autotransplantation procedures for kidney salvage.


Medicare. B. Psychiatric limitations.

Medicare. B. Psychiatric limitations.


Fibrinous colitis in swine, a manifestation of Schwartzman reaction?


Where does Nematodirus battus Crofton & Thomas, 1951, come from?


American Academy of Ophthalmology and Otolaryngology. Presidential comments.


The otolaryngologist of the far west.

The otolaryngologist of the far west.


Wilfred Trotter, F.R.S., F.R.C.S.

Wilfred Trotter, F.R.S., F.R.C.S.


Some dental problems and the surgeon.

Some dental problems and the surgeon.


Twenty-five years of photocoagulation.

Twenty-five years of photocoagulation.


Historical vignettes.

Historical vignettes.


The use of iso-shunt lines for control of oxygen therapy.


Further studies on transtracheal ventilation: the influence of upper airway obstruction on the patterns of pressure and volume changes.


A foreign body in the larynx: case report.


Lymphocyte anergy in patients with carcinoma. All of 10 patients with colonic carcinoma and 5 with malignant melanoma of skin showed no sign of immunoreactivity against the cultured tumour cells by the lymphocyte populations residing within the tumours. More than half of these patients did show cytotoxic reactivity by their blood lymphocytes. Possible cytotoxic reactivity by the regional lymph node lymphocytes was also investigated in 57 tumour cases (44 colonic, 13 melanoma, and including 12 of the 15 examined for intrinsic lymphocyte activity). One third of the cases showed positive blood lymphocyte immunoreactivity, but in only 4 tumours (3 colonic) did the node lymphocytes show any cytotoxicity against the tumour cells. This state of anergy of intrinsic and regional lymphocytes is presumably acquired during the development of the cancer and would permit local tumour spread and metastasis to lymph nodes. Its cause has not been identified but appears to be lymphocyte inhibition rather than selective change in lymphocyte population. In particular, no special pattern can be seen in the relative proportions of T and B cells in patients' blood, lymph node or intrinsic carcinoma lymphocytes.


Vasopressin analogue DDAVP in diabetes insipidus: clinical and laboratory studies. In seven patients with cranial diabetes insipidus an analogue of vasopressin, DDAVP, produced an antidiuresis lasting up to 20 hours after a single intranasal dose. Lysine vasopressin (LVP) in the same dose produced a less potent antidiuresis which lasted for only three to four hours. The plasma half life of DDAVP was 7.8 and 75.5 min for the fast and slow phases, compared with 2.5 and 14.5 min for LVP. Radioiodine-labelled DDAVP was not destroyed by incubation with late pregnancy plasma, which contains an enzyme that inactivates vasopressin. The slow metabolic clearance of DDAVP, its absorption through the nasal mucosa, and its lack of side effects make this the ideal drug for the treatment of vasopressin-sensitive diabetes insipidus. Patients usually require 10 to 20 mug DDAVP given intranasally twice daily for good clinical control of their diabetes insipidus.


Treatment of malignant hyperthermia in swine.


Fire in a nebulizer.

Fire in a nebulizer.


Medical history of British Columbia: some aspects.


Treatment of muscle cramps during maintenance haemodialysis. The effect of a slowly released oral preparation of sodium chloride (Slow Sodium) on the frequency and severity of muscle cramps, on blood pressure, and on body weight was compared with that of placebo in a double-blind cross-over trial in 19 patients on maintenance haemodialysis for end-stage renal failure. A significant reduction in both the frequency and severity of cramps was found while the patients were receiving the sodium chloride preparation and no significant alteration in blood pressure or body weight was detected.


Maurice Campbell.

Maurice Campbell.


J. Garland.

J. Garland.


Sir Cecil Hogg.

Sir Cecil Hogg.


D. K. Rao.

D. K. Rao.


We salute--Curtiss B. Hickcox, M.D.

We salute--Curtiss B. Hickcox, M.D.


J. A. Gordon.

J. A. Gordon.


J. B. Chatterjea (1919-1972).

J. B. Chatterjea (1919-1972).


The estimation of serum creatine phosphokinase activity using a reaction-rate analyser.


Urinary lysosomal glycosidases after renal allotransplantation: correlation of enzyme excretion with allograft rejection and ischemia.


University of Pennsylvania School of Dental Medicine.


Terbutaline (Bricanyl) inhaler.

Terbutaline (Bricanyl) inhaler.


Effect of endotoxin and dietary phosphorus on the proliferation of liver reticuloendothelial and bone marrow cells.


Immunological reactivity during pregnancy in the mouse.


The stereochemistry at carbon 3 of pyruvate lyase condensation products. Aldolases forming condensation products racemic at carbon 4.


Protein synthesis initiation in eukaryotes. Characterization of ribosomal factors from mouse fibroblasts.


Glycoprotein enzymes secreted by Aspergillus fumigatus. Purification and properties of beta-glucosidase.


A convenient synthesis of (2R)-glyceryl-beta-D-galactopyranoside. A substrate for beta-galactosidase, the lactose repressor, the galactose-binding protein, and the beta-methylgalactoside transport system.


Shigella sonnei phage typing Czechoslovakia.


Histology and fine structure of necrotic renal allografts in man.


12,13-Epoxytrichothecenes: potential toxic contaminants of foods.


The caloric cost of pregnancy.

The caloric cost of pregnancy. To determine the amount of extra calories a pregnant woman needs to ensure normal growth of her fetus, a study was conducted using 11 normal women who were willing to spend 1 week in the hospital during the last half of pregnancy.  The women were given a constant diet of known composition which closely approximated their normal diet at home.  Data on fasting weight and fluid balance, nitrogen excretion (from urine samples), 24-hour oxygen consumption and CO2 production were recorded daily.  The diet consisted of 80 gm. or more of high-quality protein and supplementary vitamins and iron.  7 women were in positive caloric balance eating 1600 to 2000 Kcal/day; their mean weight gain was 6.8 kg.  The other 4, who were obese or who were prone to obesity, were on a lower caloric intake of 1200 to 1600 Kcal/day; despite this, their average gestational weight gain was 10.0 kg.  All babies, except for 1 (the mother had placental insufficiency due to low implantation, premature separation, and antepartum hemorrhage; her baby weighed 2.58 kg. at 38 weeks), were born at term with a birthweight of more than 3 kg.  The authors concluded that pregnancy hardly imposes any increase in physical activity on the women, and whatever physical effort is exerted is offset by a reduction in physical activity.  A pregnant woman requires approximately 600 Kcal. daily for her activities; this amounts to total caloric requirements of 2100, 2200 and 2300 Kcal/day in each of the 3 trimesters.  12 oz. of homogenized milk per day is adequate to meet the extra caloric requirements of a well-nourished woman during her pregnancy.  The findings suggest that a normal woman need not overeat to ensure normal growth of her fetus.


Nutrition classics from Public Health Reports 31:3159-3173, 1916. The transmissibility of pellagra. Experimental attempts at transmission to the human subject.


Control of vitamin D metabolism.

Control of vitamin D metabolism.


Cooling in the emergency treatment of burns.


Oncogenous rickets: possible elaboration by a tumor of a humoral substance inhibiting tubular reabsorption of phosphate.


Shigellosis in the first week of life.

Shigellosis in the first week of life.


Anal carrier rate of group A beta-hemolytic streptococci in children with streptococcal pharyngitis.


Lysosomes, peroxisomes and bivalves.

Lysosomes, peroxisomes and bivalves.


Pentapeptide (pepstatin) inhibition of brain acid proteinase. The pentapeptide pepstatin obtained from culture filtrates of actinomycetes completely inhibited brain acid proteinase (cathepsin D) at exceedingly low concentrations. Among the brain enzymes tested, the effect is specific for acid proteinase because addition of 1000-fold higher concentrations was without effect on neutral proteinase, aminopeptidase, and arylamidases. Pepstatin also inhibits pepsin as tested with hemoglobin or with N-acetylphenylalanyl-L-diiodotyrosine as substrate. Pepstatin must be regarded as the most powerful agent yet described that inhibits intracellular acidic proteolytic enzyme in brain.


Oral anti-inflammatory therapy. A survey of the literature and some aspects of the evaluation of anti-inflammatory agents.


A comparison between different methods of culturing lactobacilli from human saliva.


The electrophoretic mobility of micro-organisms.


The beta-lactamases of gram-negative bacteria and their possible physiological role.


Purification and properties of two messenger-discriminating species of E. coli initiation factor 3.


Immunofluorescence methods for detection of influenza and mumps antibodies using infected shedded allantoic cells and impression smears of organ cultures as the sources of antigens.


A nucleotide phosphotransferase from Escherichia coli. Purification and properties.


Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences.


On the role of isoleucyl-tRNA synthetase in multivalent repression.


Spectral changes on binding of oligosaccharides to murine immunoglobulin A myeloma proteins.


Stability and homogeneity of preparations of ribosomal particles from Escherichia coli.


Rat ventral prostate chromatin. Effect of androgens on its chemical composition, physical properties, and template activity.


Thermal transitions in E. coli +RNA fMet and two of its molecular fragments.


Lamellar keratoplasty.

Lamellar keratoplasty.


Results of scleral buckling operation with an encircling thread in idiopathic retinal detachment.


A simplified technique for buckling with a circling element for retinal detachment.


Results of recession of the inferior oblique muscle.


The use of lamellar keratoplasty as a tissue therapy in corneal spring catarrh (preliminary report).


Results of trephine operation for glaucoma that may occur after 9mm. penetrating keratoplasty for total anterior staphyloma.


Management of inter-calary staphyloma and cystoid cicatrix by staphylectomy and double cyclodialysis.


Scleral buckling versus scleral resection for the treatment of retinal detachment.


Eye banking: scheme & propositions.

Eye banking: scheme & propositions.


Ptosis: some anatomical and surgical considerations.


A new technique and new instrumentarium for refractive keratoplasty.


Officers and Council of the Ophthalmological Society of Egypt.


Immunocompetent cells in the chicken. II. Synergism between thymus cells and either bursa or bone marrow cells in the humoral immune response to sheep erythrocytes.


Morphology and nucleoside incorporation of human neonatal lymphocytes.


Production of macrophage migration inhibitory factor and lymphotoxin by leukocytes from normal and Wiskott-Aldrich syndrome patients.


Experimental ulcerative disease of the colon in animals.


Malonate dulcitol lysine iron agar--a new differential medium for the identification of Salmonella subgenera I-3.


Studies on transfer ribonucleic acids and related compounds. VI. Synthesis of yeast alanine transfer ribonucleic acid 3'-terminal nonanucleotides and 5'-terminal hexanucleotides.


Carotid artery rupture.

Carotid artery rupture.


Trigeminal neuralgia: a new surgical approach. (Percutaneous electrocoagulation of the trigeminal nerve).


Columellar advancement for nasal tip elevation.


Professor William Ian Clinch Morris.

Professor William Ian Clinch Morris.


Dr. Percival Brooke Mumford.

Dr. Percival Brooke Mumford.


The American connection: handguns and homicide.


Retinal microglia in cases of choroidal melanoblastoma.


Suggestion for reducing haemorrhage in operations on the lacrimal sac.


Urinary proteins of the rat during CCl4 poisoning.


Adrenochrome and related compounds.

Adrenochrome and related compounds.


A 1973 look at hemophilia and von Willebrand's disease.


Simulation of a cell cycle model of slowly growing Eschericha coli cells.


Studies on the antigenic structure of Shigella. VII. Structure of the O-specific side chains of the lipopolysaccharides from strains 2 (serotype lb) and 1290-63 (variant Y).


Chemical mutagenesis in Taphrina maculans Butler. I. Survival and mutation induction by N-methyl-N'-nitro-N-nitrosoguanidine.


A comment to the concept on the role of nitrate fermentation and nitrate respiration in an evolutionary pathway of energy metabolism.


Acquisition of three-dimensional structure of proteins.


Structure and function of phage RNA.

Structure and function of phage RNA.


Nuclear RNA metabolism.

Nuclear RNA metabolism.


Neurotoxins of animal venoms: snakes.

Neurotoxins of animal venoms: snakes.


Structure of chromosome fibers and chromosomes.


Electronmicroscopy of genetic activity.

Electronmicroscopy of genetic activity.


Protein synthesis.

Protein synthesis.


In memoriam. Alexander Michael Boyd (1905-1973).


Mechanisms of antibiotic resistance in bacteria.


Microtubules.

Microtubules.


Biochemistry of bacterial membranes.

Biochemistry of bacterial membranes.


Environmental mutagenesis and repair.

Environmental mutagenesis and repair.


Studies on the metabolism of ATP by isolated bacterial membranes: solubilization and phosphorylation of a protein component of the diglyceride kinase system.


Outer membrane proteins of Escherichia coli. I. Effect of preparative conditions on the migration of protein in polyacrylamide gels.


Outer membrane proteins of Escherichia coli. II. Heterogeneity of major outer membrane polypeptides.


Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability.


The action of free endotoxin of Shigella sonnei on the leukocytic system in rabbits.


Serologic analysis of Escherichia K12 HfrCxShigella flexneri 1a recombinants.


Role of easily released substances (ERS) from bacteria into physiologic solutions in natural immunity. I. Influence of easily released substances from bacteria on phagocytosis in vitro.


Repeated immunization of rabbits with sheep red blood cells. IV. Influence of splenectomy on presence of PFC and RFC in peripheral blood.


Diallel analyses of water intake, body weight, and percent hemoconcentration in male mice.


Some initial animal and human pharmacological studies with benapryzine (BRL 1288). 1. The pA2 anti-acetylcholine activity in vitro for benapryzine was 6.55 compared with 9.02 for benzhexol.2. In vivo, the anti-acetylcholine activity of benapryzine relative to benzhexol was 0.038 as assessed by the mydriatic response of mice after subcutaneous administration. The relative activity assessed by the inhibition of pilocarpine-induced salivation was 0.13 after oral administration and 0.056 following subcutaneous administration of the drugs.3. Benapryzine had the same order of activity as benzhexol in inhibiting oxotremorine-induced tremors in mice.4. Benapryzine had anticonvulsant properties but no analgesic activity, whilst in high doses it antagonized the extrapyramidal symptoms induced by perphenazine in rats.5. In patients benapryzine was effective in reducing the symptoms of Parkinson's disease without overt anti-cholinergic effects or central hallucinogenic actions.6. Benapryzine abolished the excess tremor and reduced the rigidity and akinesia induced by physostigmine in Parkinsonian subjects.


Intracranial self-stimulation and noradrenaline metabolism in cortex.


Second renal transplants in cvhildren.

Second renal transplants in cvhildren.


The Donald T. Fraser Memorial Lecture, 1973. Landmarks and pioneers in the control of diphtheria.


Animal DNA-dependent RNA polymerases. Initiation sites on calf-thymus DNA.


Outer membrane of salmonella. Sites of export of newly synthesised lipopolysaccharide on the bacterial surface.


Modification of carboxyl groups in pepsin.


The functions of rho in T7-DNA transcription in vitro.


A specific ribonucleoprotein fragment from Escherichia coli 30-S ribosomes. Location of the RNA component in 16-S RNA.


Fluorescent labels on ribosomes. Action of the carcinogen 7-bromomethylbenz[a]anthracene.


A transport system for 2-keto-3-deoxy-D-gluconate uptake in Escherichia coli K12. Biochemical and physiological studies in whole cells.


Transcription in vitro using mixtures of ethylene glycol and water.


The genetic control of molybdoflavoproteins in Aspergillus nidulans. Allopurinol-resistant mutants constitutive for xanthine-dehydrogenase.


Formation of the yeast mitochondrial membrane. 2. Effects of glucose repression on mitochondrial protein synthesis.


Isolation and properties of isoleucyl-tRNA synthetase from Escherichia coli MRE 600.


Ultracentrifuge studies on binding of aliphatic amino acids to isoleucyl-tRNA synthetase from Escherichia coli MRE 600.


The draw-a-man test: a study of scoring methods, validity and norms with English children at five and eleven years.


The effects of maternal employment on children.


Decay of messenger ribonucleic acid from the lactose operon of Escherichia coli as a function of growth temperature.


Biosynthesis of the beta and beta' subunits of RNA polymerase in Escherichia coli.


Release of 70 S ribosomes from polysomes in Escherichia coli.


Relationship between the concentration of nucleoside triphosphates and the rate of synthesis of RNA.


Process of cellular division in Escherichia coli growth pattern of E. coli murein.


Relationship between chromosome replication and F'lac episome replication in Escherichia coli.


Replication of a specific terminal chromosome segment in Escherichia coli which is required for cell division.


Physical mapping of the transfer RNA genes on lambda-h80dglytsu+36.


Secondary structure in transfer RNA genes.


Serotonin and central nervous system syndromes of childhood: a review.


Ring-current shifts in the 300 MHz nuclear magnetic resonance spectra of six purified transfer RNA molecules.


Assignment of the low field proton nuclear magnetic resonance spectrum of yeast phenylalanine transfer RNA to specific base pairs.


[Bibliography of the literature on antibiotics published in foreign countries. 95].


Small intestine carbohydrase activities in experimental Salmonella enterocolitis in mice.


The effects of a protein-free diet on the immune response of rats to sheep red blood cells. Role of the thymus.


Deglycyrrhizinated liquorice in duodenal ulcer.


A buffered cream for napkin rashes.

A buffered cream for napkin rashes.


'Phenomenon Young'. Thomas Young, M.D., F.R.S.


The Schick test. Bela Schick (1877-1967).


Elinor Emrys-Roberts.

Elinor Emrys-Roberts.


Benign strictures of the cervical oesophagus.


The agent possibly associated with swine dysentery and the antigenic relationship with Borrelia canis.


Intestinal defence in the young pig--a review of the secretory antibody systems and their possible role in oral immunisation.


Scanning electron microscopic studies of the human nasal mucosa in normal persons and in patients with perennial rhinitis. I. Cilia and microvilli.


Molecular embryology of invertebrates.

Molecular embryology of invertebrates.


The organization center of the amphibian embryo: its origin, spatial organization, and morphogenetic action.


Photomorphogenesis and nucleic acid metabolism in fern gametophytes.


The development, inheritance, and origin of the plastid in Euglena.


Variation of the size of the reacting form of Escherichia coli K12 threonine-sensitive aspartokinase--homoserine dehydrogenase with pH and effectors.


Amino acid sequence of Escherichia coli alkaline phosphatase. Amino- and carboxyl-terminal sequences and variations between two isozymes.


Penicillamine in rheumatoid arthritis.

Penicillamine in rheumatoid arthritis.


The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat.


The Federal Food and Drug Administration in the United States: born and bred in crises.


Effect of testosterone on the LH and FSH release induced by LH-releasing factor (LRF) in normal men.


Biochemical and clinical considerations of new drug investigation.


Piromidic acid and beta-hydroxypiromidic acid: therapeutic effectiveness on experimental E. coli pyelonephritis in the rat.


Radiation therapy of giant follicular lymphoma.


Mechanical preparation of pour plates for viable bacterial counts of milk samples.


Composition of proteins in milk with varying leucocyte contents.


Creutzfeldt-Jakob disease treated with amantidine. A report of two cases. The treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral.


Effect of the beta adrenergic blocking agent propranolol on essential tremor. A double blind trial of a single 40 mg dose of the beta adrenergic blocking agent propranolol in the treatment of essential tremor produced significant reduction of tremor in four of five patients, but this effect was transient and had considerably diminished within four hours. A month's double blind clinical trial of propranolol, in a dose of 30 mg three times a day, showed that the active drug gave statistically better results than placebo for the attenuation of tremor. The mode of action of propranolol in the reduction of essential tremor is probably a dual one, due both to blockage of peripheral beta receptors and to a central depressant effect.


Adoptive transfer of immunity to Plasmodium berghei by spleen and lymph node cells from young and old mice.


Some qualitative aspects of spleen cell transfer studies on Plasmodium berghei-infected rats.


The paediatrician and the physical education of the child.


Medicine and physical exercise in ancient India.


Relationships of indicator and pathogenic bacteria in stream waters.


Host controlled restriction and modification of bacteriophage Mu and Mu-promoted chromosome mobilization in Citrobacter freundii.


Stimulation of T7 DNA polymerase by a new phage-coded protein.


The child with congenital anomalies of the central nervous system.


Bacterial cell division: its regulation and relation to DNA synthesis.


Diet and heart disease.

Diet and heart disease.


Bacterial mesosomes.

Bacterial mesosomes.


A measure of family functioning and its application.


History of psychiatry.

History of psychiatry.


To the memory of Johan Booij, 14th November 1902-21st November 1972.


Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.


Rejection and enhancement in an in vitro model of alloimmunity.


The distribution of histocompatibility antigens on T and B cells in the guinea pig.


Cellular and humoral factors governing canine mixed lymphocyte cultures after renal transplantation.


Nongenetic host factors that affect the probability of rejection of H-X allografts in the mouse.


Derrick Tilton Vail, 1898-1973, President of the Academy, 1951.


Restoration of the mandible following partial resection.


The appearance of reticulum cell sarcoma at the site of antilymphocyte globulin injection.


Neuraminidase-induced delay of mouse skin graft rejection.


Prof Dr. Gerd Rudolf Edmund Meyer-Schwickerath.


Medicare. B. Prohibition against reassignment of claims.


Prolonged survival of canine renal allografts by pretreatment with viable lymphoid cells.


Alden H. Miller, MD.

Alden H. Miller, MD.


Tamm-Horsfall glycoproteinuria and renal allograft rejection.


Regional bone-muscle-skin pedicle flaps in surgery of the head and neck.


Penetrating wounds of the tympanic membrane and ossicular chain.


Francis Loeffler Lederer, 1898-1973, President of the Academy, 1968.


The bivalve teflon nasal septal splint.

The bivalve teflon nasal septal splint.


The immunology of cancer: avenues to immunotherapy.


Prevention of smallpox in Alta California during the Franciscan Mission Period (1769-1833).


Senile spastic entropion of upper lid.

Senile spastic entropion of upper lid.


Surgical repair of tympanic membrane perforations.


Gene symbols in Aspergillus nidulans.

Gene symbols in Aspergillus nidulans.


Surface exclusion by ColV-K94.

Surface exclusion by ColV-K94.


Recent progress in epilepsy. Diagnostic procedures and treatment.


A double blind study of Visken LB-46, in the treatment of angina pectoris.


A new beta receptor blocking agent LB-46 in angina pectoris. (A double blind clinical trial).


A double blind drug trial of LB-46 (visken) in angina pectoris.


The effect of the persistence of juvenile hormone mimics on their activity on Rhodnius prolixus.


Visken (LB-46) a double blind cross-over study in cardiac arrhythmias.


Pemphigus foliaceus occurring in a roofer.


Congenital malformations and environmental influence: the occupational environment of laboratory workers.


Energy changes during ensilage.

Energy changes during ensilage.


"Give a kidney-save a life".

"Give a kidney-save a life".


Complete avulsion of the genital skin.

Complete avulsion of the genital skin.


Kidney transplantation in Nova Scotia. A four year review.


Tracheal stenosis secondary to cuffed tubes.


Observations on the relationship between lymphosarcoma and Hodgkin's disease.


Effect of urea on the plasma membrane particles in yeast cells and protoplasts.


The task of the transplantation centre of the Institute for Clinical and Experimental Medicine and the present state of the transplantation programme in the Czechoslovak Socialist Republic.


Hemophilus influenzal disease-drug therapy and prospects of a vaccine.


Ultrastructure of oocytes from the American oyster Crassostrea virginica Gmelin.


Guide to the literature on Tetrahymena: a companion piece to Elliott's "General Bibliography".


Acridine orange-epifluorescence technique for counting bacteria in natural waters.


Medical phonography: the story of shorthand in medicine.


On the health of Charles Darwin.

On the health of Charles Darwin.


Directory of Fellows of the College of Physicians of Philadelphia.


Bacterial exopolysaccharides.

Bacterial exopolysaccharides.


The determination of cadmium by atomic absorption in air, water, sea water and urine with a R.F. carbon bed atomizer.


Regulation of RNA metabolism of T7 and related phages.


The molecular basis of hemoglobin disease.


The immediate development of behavioral and biochemical changes following ventromedial hypothalamic lesions in rats.


The template specificities of DNA polymerase in cell free lysates of Xenopus laevis eggs, larvae and immature ovaries.


The accumulation of glycinamide ribotide by ade3 and ade8 mutants of Saccharomyces cerevisiae.


Isolation of a complementing activity for a dna-B mutant.


Orthophosphate and histone dependent polyphosphate kinase from E. coli.


Complex formation between transfer RNAs with complementary anticodons: use of matrix bound tRNA.


Equilibrium dialysis binding studies of 1,N6-ethenoadenosine diphosphate (epsilon ADP) to myosin, heavy meromyosin, and subfragment one.


The end groups of T7 mRNA.

The end groups of T7 mRNA.


7Alpha-hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies.


The structure of Escherichia coli membranes studied by fluorescence measurements of lipid phase transitions.


"Xenogeneic resistance" to rat bone marrow transplantation. II. Relationship of hemopoietic regeneration and survival.


Purification of lipoamide dehydrogenase by affinity chromatography on propyllipoamide-glass columns.


Non-reactivity of incompatible lymphoid cells from f1 modified radiation chimeras to host tumour cells in vitro.


Genetic resistance to marrow transplantation.


Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotropins in hypophyso-gonadal disorders of children and adolescents. II. Precocious puberty and premature thelarche.


Stimulation of hypotensive activity in the kidney of rats by compensatory hypertrophy: inhibition effect of puromycin.


An eleven-year clinical investigation of Harrington instrumentation. A preliminary report on 578 cases.


The 1974 U.S. budget--past, present, and future.


Alleviation of post-perfusion complications by autofiltration of cardiotomy blood return in 100 patients: a comparison with sequential controls.


Parasitological societies of the world.

Parasitological societies of the world.


Pathological changes in parasitic infections of the intestine of calves and lambs: a technique for avoiding post-mortem artefacts.


Analysis of specific misreading in Escherichia coli.


Structural genes for catalytic and regulatory subunits of aspartate transcarbamylase.


Respiratory distress syndrome in the adult after cardiopulmonary bypass. A successful therapeutic approach.


Farmer's lung: man's oldest occupational illness.


Abdominal mass in the newborn infant.

Abdominal mass in the newborn infant.


Nursing care study: a severely burned patient.


Early foundations of dermatology.

Early foundations of dermatology.


Penicillin antibodies and immunoglobulin production in newborn infants: studies with chemically modified bacteriophage.


The adaptation of hydrogen ion excretion associated with nephron reduction in post-transplant patients.


John E. Farrell, A.B., Sc.D.

John E. Farrell, A.B., Sc.D.


Clovis Vincent. 1879-1947.

Clovis Vincent. 1879-1947.


Recent advances in venous thrombo-embolism. A review article.


Psoriatic arthritis.

Psoriatic arthritis.


A corneal trephine press.

A corneal trephine press.


Phytosterols.

Phytosterols.


Microbiological transformation of bile acids.


Viruses and autoimmunity.

Viruses and autoimmunity.


Clinical and pathologic aspects of the corneal graft reaction.


Algernon B. Reese, MD.

Algernon B. Reese, MD.


The hematologic disorders of alcoholism.


Overview: current trends in mental health law.


Current methods of in-vivo measurement of osteoporosis.


Natural history of Candida species and yeasts in the oral cavities of infants.


Air pollution and respiratory illness.

Air pollution and respiratory illness.


Radiation carcinogenesis.

Radiation carcinogenesis.


Investigation of extracranial cerebrovascular disease using a 70mm. rapid sequence camera.


Transport across isolated bacterial cytoplasmic membranes.


Testicular feminization in the mouse: studies of Leydig cell structure and function.


Mouse leucocyte chromosomes: in vitro culture.


C-mitosis without colchicine in human leucocyte cultures.


The present status of liver transplantation.


Pressure-flow and pressure-volume relationships in the fetal placental circulation.


A method for the separate detection of tritium and iodine radioisotopes in the same cell smear using a double autoradiographic stripping technique.


Wound healing: a review.

Wound healing: a review.


Sero-epidemiology of arboviruses in Indonesia.


Childhood schizophrenia reconsidered.

Childhood schizophrenia reconsidered.


Nutmeg and mace, the psychotropic spices from Myristica fragrans.


Response to triiodothyronine and dextroamphetamine: a study of preschool schizophrenic children.


1932--the death of Babinski.

1932--the death of Babinski.


A salute to baseball's patron saint.

A salute to baseball's patron saint.


Dr. Sappington's fever pills.

Dr. Sappington's fever pills.


Don't talk--draw.

Don't talk--draw.


Effect of famine on later mental performance.


Smoking, pregnancy, and development of the offspring.


Growth and zinc deficiency.

Growth and zinc deficiency.


Rare forms of familial vitamin B12 malabsorption in children.


Nutrition classics from Public Health Reports. The prevention of pellagra. A test of diet among institutional inmates.


Cortisone induction of small bowel sucrase activity.


Carbohydrate preference in normal and malnourished rats.


Ascorbic acid and the catabolism of cholesterol.


Tryptophan and the brain.

Tryptophan and the brain.


Effects of brief postnatal fasting upon brain development in rabbits.


Protein requirements of fish.

Protein requirements of fish.


A rapid and reliable technique for pinealectomizing rats.


Performance of a motor task after cerebellar cortical lesions in rats.


Effects of brain-stem lesions on instrumental conditioning in cats.


The fornix as a reward pathway.

The fornix as a reward pathway.


Training and task-related differences in retrograde amnesia thresholds determined by direct electrical stimulation of the cortex in rats.


Effect of brain-stem lesions on retention of a conditioned reflex in cats.


Attack, grooming, and threat elicited by stimulation of the pontine tegmentum in cats.


Morphological basis of alveolar-capillary gas exchange.


Odor and flavor compounds from lipids.

Odor and flavor compounds from lipids.


Stamps in radiology (Leon Charles Albert Calmette).


Mitral valve prolapse--Click syndrome.

Mitral valve prolapse--Click syndrome.


Memoir of John Rodman Paul 1893-1971.

Memoir of John Rodman Paul 1893-1971.


Dialysis of poisons and drugs--annual review.


Profile of the enzymes of the Krebs cycle in Salmonella typhimurium during the utilization of succinate, acetate, and citrate for growth.


The vicissitudes and vivification of Viki Vaughn.


The physiology and degeneration of joints.


Resorptive arthropathy and the opera-glass hand syndrome.


New diagnostic tests in thoracic surgery. A perspective.


Denture movements and control. A prelimary study.


Atropine action in caerulein-stimulated and pylorus ligated rats.


American doctors and the Parisian medical world, 1830-1840.


Joseph M. Toner (1825-1896) as a medical historian.


Design and construction of partial dentures externally retained. 2.


The importance of serial angiography and subtraction for the operative indication in hemangiomas of the facial region.


Early detection of learning problems: questions, cautions, and guidelines.


Dorothy Schullian's retirement.

Dorothy Schullian's retirement.


Letter of a frontier doctor.

Letter of a frontier doctor.


1973-74 membership directory.

1973-74 membership directory.


Preservation of the heart.

Preservation of the heart.


The importance of the lysyl residue in goat anti-dinitrophenyl antibodies modified by site-directed reagents.


Obituary. Dr. M. M. Nanavati.

Obituary. Dr. M. M. Nanavati.


100 years of internships.

100 years of internships.


Women, menstruation, and nineteenth-century medicine.


Health screening for medicaid eligible children in Mississippi: results of the first three years of screening.


Mental health and work environment: an examination of the evidence.


Serologic surveys for avian encephalomyelitis and chicken-embryo-lethal-orphan viruses in chickens in Korea.


Edwards A. Park: an appreciation of the man.


Pathological studies on swine leukosis. Fine structure of reticulum cell sarcoma and lymphosarcoma.


An affair to remember.

An affair to remember.


Cardiovascular complications of chronic bronchitis and emphysema.


Treatment of renal failure--Hobson's choice.


Cardiogenic shock. Recent advances in pharmacologic management.


Treatment of cardiogenic shock.

Treatment of cardiogenic shock.


Surgical approach to breast cancer.

Surgical approach to breast cancer.


Mebeverine in patients with the irritable colon syndrome: double blind study.


Gerald Jacob Frengley.

Gerald Jacob Frengley.


Frederick John Appleby.

Frederick John Appleby.


Edward John Cronin.

Edward John Cronin.


A review: human erythrocyte acetylcholinesterase.


Nicotine-containing chewing gum as an anti-smoking aid.


The genetics of early human development.


The problem of genetic identity of different cell types.


Nucleic acid hybridization and the nature of chromosomal protein bound RNA.


Significance of acetaldehyde in ethanol-induced effects on catecholamine metabolism and motor activity in the mouse.


What the practicing veterinarian should know about gerbils.


Incompatibility between F and F' Episomes in Escherichia coli bearing mutation affecting superinfection immunity.


The effect of Mg2+ and spermine on aminoacylation of tRNAphe by homologous and heterologous enzymes.


Preparation of local Shwartzman reaction by means of platelet rich plasma.


External diseases of the eye.

External diseases of the eye.


Neurological substrates of aggressive behavior.


Variation in performance of oxygen therapy devices. Towards the rational employment of 'The dephlogisticated air described by Priestley'.


Secretion of gastrointestinal hormones.

Secretion of gastrointestinal hormones.


Sugar-induced diarrhoea in children.

Sugar-induced diarrhoea in children.


Anesthetic problems of the acute quandriplegic patient.


The uvea.

The uvea.


Specific pharmacological management of acute toxicity due to "psychedelic" drugs.


Liver function: a review.

Liver function: a review.


Distinct effects of diamines, polyamines, and magnesium ions on the stability of lambda phage heads.


Immunoglobulin nascent chains on membrane-bound ribosomes of myeloma cells.


Use of somatic cell hybrids for analysis of the differentiated state.


Pseudouridine deficiency in transfer ribonucleic acids from Escherichia coli treated with 2-thiouracil.


Methyl 4-mercaptobutyrimidate as a cleavable cross-linking reagent and its application to the Escherichia coli 30S ribosome.


Rate determining step in the reconstitution of Escherichia coli 30S ribosomal subunits.


Divalent cation and pH dependent primary isotope effects in the enolase reaction.


A technique for the detection of deleted immunoglobulin heavy chains.


Differences between national suicide rates.


Malignant hyperpyrexia.

Malignant hyperpyrexia.


Some recollections of the birth, infancy and childhood of the American Orthopsychiatric Association.


Vaginal and oral nitrimidazine in the treatment of vaginal trichomoniasis.


Bibliography of Karl Menninger, M.D. from January 1919 through June 1973.


Cardiomyopathy associated with systemic diseases.


Laboratory diagnosis of rubella virus infections.


Chemical interference by drugs and other substances with clinical laboratory test procedures.


Blood oxygenation in extracorporeal devices: theoretical considerations.


The measurement of flow in intact blood vessels.


The biomechanical properties of skin.

The biomechanical properties of skin.


Laryngeal stridor and respiratory obstruction associated with myelomeningocele.


The cell population of dorsal root ganglia in children with neurospinal dysraphism.


2-Amino-2-deoxyhexuronic acid: a constituent of Shigella sonnei phase I lipopolysaccharide.


Enzymatic degradation of O-antigenic lipopolysaccharides by coliphage omega 8.


The mechanism of action of methionyl-tRNA synthetase from Escherichia coli. 1. Fluorescence studies on tRNAMet binding as a function of ligands, ions and pH.


The mechanism of action of methionyl-tRNA synthetase. 2. Interaction of the enzyme with specific and unspecific tRNAs.


The mechanism of action of methionyl-tRNA synthetase. 3. Ion requirements and kinetic parameters of the ATP-PPi exchange and methionine-transfer reactions catalyzed by the native and trypsin-modified enzymes.


Nucleoside-catabolizing enzymes in Salmonella typhimurium. Introduction by ribonucleosides.


Endonuclease activity associated with the DNA protein complex of minicircular DNA of Escherichia coli 15.


The conformational transitions in yeast tRNAPhe as studied with tRNAPhe fragments.


Psychopharmacological news in the year 1971 from the viewpoint of a medicinal chemist.


Replicating Rodac plates for identifying and enumerating bacterial contamination.


G. J. Neary, 1912-1972.

G. J. Neary, 1912-1972.


Transfer amyloidosis.

Transfer amyloidosis.


Dialysis and transplantation services in Israel. A criticism of their organization.


Immunological aspects of amyloidosis.

Immunological aspects of amyloidosis.


Cholera and other enterotoxin-related diarrheal diseases.


Modern trends in chemoprophylaxis in tuberculosis.


Bone resorption and prosthodontics.

Bone resorption and prosthodontics.


Chronic acral dermatitis: association with extreme elevations of IgE.


Postaortotomy myoctic pseudoaneurysm. A nonvalvular, potentially resectable source of intravascular sepsis following prosthetic valve surgery.


Carl Vernon Moore.

Carl Vernon Moore.


The influence of sodium chloride on the growth and production of macroconidia of Trichophyton mentagrophytes.


Haemichrome formation during the in vitro oxidation of Hb Köln.


Neurologic manifestations of infectious endocarditis, 1972.


The physics and biology of animal reflectors.


The rational management of ascites.

The rational management of ascites.


Albumin metabolism.

Albumin metabolism.


Photochemical and biochemical basis of the treatment of neonatal jaundice.


Practical aspects of migraine.

Practical aspects of migraine.


Drug treatment in bronchial asthma.

Drug treatment in bronchial asthma.


The treatment of allergic contact dermatitis.


Method allowing biological and biochemical studies of vacuum exposed bacteria.


Chemical evolution and the origin of life. Bibliography supplement 1971.


Effect of pressure on biopolymers and model systems.


Diagnostic studies of pleural fluid.

Diagnostic studies of pleural fluid.


Comparative investigations on the pressure tolerance of marine invertebrates and fish.


Some mechanisms involved in the cardiovascular adaptations to diving.


Pressure and the rhythmic behaviour of inshore marine animals.


The effects of pressure on organisms: a summary of progress.


The benzodiazepines.

The benzodiazepines.


What the practicing veterinarian should know about guinea pigs.


An adjustable suture: a technique for altering the tension of stitches postoperatively, especially in third-lid flaps.


Comparison of ampicillin and sulfachlorpyridazine in treatment of colibacillosis in swine.


Immediate and delayed MPN determinations of thermotolerant E. coli in seawater.


Calcitonin in metabolic disorders.

Calcitonin in metabolic disorders.


On the transmission of alloxan diabetes and other diabetogenic influences.


Subjects' recent life changes and their near-future illness susceptibility.


The role of the skin in carbohydrate metabolism.


Primary neuro-ophthalmological presentation of Burkitt's lymphoma.


Muscular dystrophy, 1865 (Wilhelm Griesinger).


Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis.


Mercury and the gut.

Mercury and the gut.


A review and reevaluation of the histiocytic disorders.


Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease.


Drug metabolism in the newborn.

Drug metabolism in the newborn.


Cytokinetics in diseases of epidermal hyperplasia.


Urethrovesical dysfunction and infection.


Drug facilitation of learning and memory.


Allergy to penicillin and related antibiotics: antigenic and immunochemical mechanism.


Delayed-type hypersensitivity and immunoglobulin levels in the course of chemotherapy of advanced malignant neoplasms.


Artificial immunization of rabbits against experimental syphilis. II. Immunological side effects of the treponemal vaccine.


Site selection by parasitic helminths: interspecific interactions, site segregation, and their importance to the development of helminth communities.


Rapid atrial stimulation in the treatment of supraventricular tachycardia.


Current surgical approach to ischemic heart disease.


Variations in arterial blood pressure after kidney transplantation. Relation to renal function, plasma renin activity, and the dose of prednisone.


Progress in measuring epithelial turnover in the villus of the small intestine.


Growth and development of normal and diseased gastrointestinal cells.


Toxicology of pesticides: recent advances.


Immunodeficiency in developmental perspective.


Tracheostomy: surgical problems and complications.


Use of extracorporeal circulation in children.


Medical audio response telecommunication information network.


Ocular manifestation of herpes simplex in the newborn (neonatal ocular herpes).


Compression of histological sections of paraffin embedded tissues.


Sources of educational materials on venereal disease.


Reminiscences of Pavlov.

Reminiscences of Pavlov.


Monumental brasses of British physicians.


A review of experimental human fungus infections.


Alopecia: syndromes of genetic significance.


Hirsutism: a review of the genetic and experimental aspects.


Cutaneous manifestations of immunogenetic deficiency disorders.


Transplantation and cutaneous genetics.

Transplantation and cutaneous genetics.


Public law 92-603.

Public law 92-603.


Tyrosyl transfer ribonucleic acid synthetase from Escherichia coli B. Analysis of tyrosine and adenosine 5'-triphosphate binding sites.


Synthesis of 6-(alpha-hydroxy-beta-N,N-dialkylaminoethyl) phenanthridines as potential antimalarials.


Evaluation of an enamel adhesive to prevent marginal leakage: an in vitro study.


Pharmaceutical sciences--1972: literature review of pharmaceutics. I.


A study of progonasyl using prostitutes in Nevada's legal houses of prostitution.


Gonorrhea screening.

Gonorrhea screening.


Macrophage activation in tuberculin reactions of rabbits with primary BCG infection and reinfection.


Obituary: Prof. Paul Chailley-Bert (1890-1973).


Peritoneal macrophage response in neonatal mice.


Increased intracranial pressure in children.


Rheumatic fever.

Rheumatic fever.


The Liverpool Medical School and its physicians (1642-1934).


Annals of a Teesside practice, 1793-1969.


The fiftieth anniversary of insulin discovery. The pioneer work of the Rumanian physiologist Nicolas Paulesco.


Infantile cortical hyperostosis (a report of five cases).


Laboratory diagnosis of genetic disorders.


Minimal brain dysfunction in children. Diagnosis and management.


Genetic disorders associated with mental retardation. Clinical aspects.


Medicinal applications of hexahydroazepine derivatives.


Interfacial phenomena and biomaterials.

Interfacial phenomena and biomaterials.


Ethics and law on behalf of the mentally retarded.


Utilization of D- and DL- amino acids and analogs.


The effects of a cantilever posterior fixed partial denture on abutment mobility: a clinical study.


Clinical syndromes associated with thymic disorders.


Changes in extracellular fluid after trauma.


Criminal psychopathology.

Criminal psychopathology.


New surgical approaches to coronary heart disease.


Adenoacanthoma and ulcerative colitis: case report and review of the literature.


Intestinal parasitic infestation in Fars Province, Iran.


Studies on homologous and heterologous antibody responses to infections with Anaplasma marginale and A. centrale using the indirect fluorescent antibody and capillary tube agglutination tests.


Possible role of cyanide and thiocyanate in the etiology of endemic cretinism.


Cretinism and the fetal-maternal relationship.


Migrant populations and the diffusion of the sickle-cell gene.


James Jackson, Jr., and emphysema.

James Jackson, Jr., and emphysema.


Language assessment: some underlying assumptions.


New Mexico Foundation for Medical Care-a computer-assisted professional standards review organization.


Roger B. Maas (1914-1973).

Roger B. Maas (1914-1973).


Adenosine diphosphate sulphurylase activity in leaf tissue. 1. A new method is described for the assay of ADP sulphurylase. The method involves sulphate-dependent [(32)P]P(i)-ADP exchange; the method is simpler, more sensitive and more direct than the method involving adenosine 5'-sulphatophosphate-dependent uptake of P(i). 2. ADP sulphurylase activity was demonstrated in crude extracts of leaf tissue from a range of plants. Crude spinach extract catalysed the sulphate-dependent synthesis of [(32)P]ADP from [(32)P]P(i); spinach extracts did not catalyse sulphate-dependent AMP-P(i), ADP-PP(i) or ATP-P(i) exchange under standard assay conditions. ADP sulphurylase activity in spinach leaf tissue was associated with chloroplasts and was liberated by sonication. 3. Some elementary kinetics of crude spinach leaf and purified yeast ADP sulphurylases in the standard assay are described; addition of Ba(2+) was necessary to minimize endogenous P(i)-ADP exchange of the yeast enzyme and crude extracts of winter-grown spinach. 4. Spinach leaf ADP sulphurylase was activated by Ba(2+) and Ca(2+); Mg(2+) was ineffective. The yeast enzyme was also activated by Ba(2+). The activity of both enzymes decreased with increasing ionic strength. 5. Purified yeast and spinach leaf ADP sulphurylases were sensitive to thiol-group reagents and fluoride. The pH optimum was 8. ATP inhibited sulphate-dependent P(i)-ADP exchange. Neither selenate nor molybdate inhibited sulphate-dependent P(i)-ADP exchange and crude spinach extracts did not catalyse selenate-dependent P(i)-ADP exchange. 6. The presence of ADP sulphurylase activity jeopardizes the enzymic synthesis of adenosine 5'-sulphatophosphate from ATP and sulphate with purified ATP sulphurylase and pyrophosphatase.


Adenosine 5'-triphosphate sulphurylase from Saccharomyces cerevisiae. 1. ATP sulphurylase from Saccharomyces cerevisiae was purified 140-fold by using heat treatment, DEAE-cellulose chromatography and Sepharose 6B gel filtration. 2. The enzyme was stable at -15 degrees C, optimum reaction velocity was between pH7.0 and 9.0, and the activation energy was 62kJ/mol (14.7kcal/mol). 3. The substrate was shown to be the MgATP(2-) complex, free ATP being inhibitory. 4. Double-reciprocal plots from initial-velocity studies were intersecting and the K(m) of each substrate was determined at infinite concentration of the other (K(m) MgATP(2-), 0.07mm; MoO(4) (2-), 0.17mm). 5. Radio-isotopic exchange between the substrate pairs, adenosine 5'-[(35)S]sulphatophosphate and SO(4) (2-), (35)SO(4) (2-) and adenosine 5'-sulphatophosphate, occurred only in the presence of either MgATP(2-) or PP(i). This suggests, along with the initial-velocity data, a sequential reaction mechanism in which both substrates bind before any product is released. 6. The enzyme reaction was specific for ATP and was not inhibited by l-cysteine, l-methionine, SO(3) (2-), S(2)O(3) (2-) (all 2mm) nor by p-chloromercuribenzoate (1mm). 7. Competitive inhibition of the enzyme with respect to MoO(4) (2-) was produced by SO(4) (2-) (K(i)=2.0mm) and non-competitive inhibition by sulphide (K(i)=3.4mm). 8. Adenosine 5'-sulphatophosphate inhibited strongly and concentrations as low as 0.02mm altered the normal hyperbolic velocity-substrate curves with both MgATP(2-) and MoO(4) (2-) to sigmoidal forms.


Contact dermatitis XXII. Dermatitis from lanolin.


Comparative physiology of sweating.

Comparative physiology of sweating.


Infective endocarditis: a changing disease. I.


Method for assessing therapeutic potential of anti-inflammatory antirheumatic drugs in rheumatoid arthritis. A 14-day, single-blind trial of prednisone, aspirin, and placebo was carried out in 128 patients suffering from rheumatoid arthritis, using subjective criteria only (severity of pain daily on a pain chart and assessment of the drug for effectiveness). The average treated pain rating, mean patient satisfaction rating, and mean number of days withdrawn from each drug all showed significant differences between prednisone, aspirin, and placebo. Of various pretreatment observations, only the initial pain score and articular index of joint tenderness were significantly related to the average treated pain rating.The trial method is simple and allows many patients to participate without being time consuming for patient or physician. The method seems to have potential in comparing the comparative effectiveness of anti-inflammatory analgesics used in the treatment of patients with rheumatoid arthritis.


L. Findlay.

L. Findlay.


H.J. Nightingale.

H.J. Nightingale.


Hirsch SR, Leff JP, Wing JK:Outpatient maintenance of chronic schizophrenics with long-acting fluphenzine.


C.B. Picken.

C.B. Picken.


R.M. Mackenzie.

R.M. Mackenzie.


Colonel E.S. Phipson.

Colonel E.S. Phipson.


The effect of differential hippocampal lesions and pre- and postoperative training on extinction.


Function of cardiac receptors.

Function of cardiac receptors.


Serial angiotomography with subtraction.


Some congenital abnormalities: possibly due to embryonic peripheral neuropathy.


In memoriam: Dr. Peter Charles Conlon.

In memoriam: Dr. Peter Charles Conlon.


The clinical significance of malaria parasitaemia in children.


A comparison of the pharmacological activity of delta 9-tetrahydrocannabinol and its monohydroxylated metabolites in man.


Structural coupling between pancreatic islet cells.


Effects of nerve growth factor on competent chick ectoderm.


The effect of tilting ultrathin sections on the image of the Z-disc of skeletal muscle.


Effect of synthetic luteinizing hormone releasing hormone on pituitary and serum levels of luteinizing hormone of intact and median eminence lesioned male rats.


The role of glycine in the biosynthesis of steroids.


Jerzy Kreiner.

Jerzy Kreiner.


Determination of C-terminal group of aspergillopeptidase Af.


Toward a chronotherapy of neoplasia: tolerance of treatment depends upon host rhythms.


Studies of leukergy in skin graft rejection in mice.


Studies on cells isolated from infiltrations of skin allo- and isografts in mice.


Admission of Dr. Charles Dickso to honorary fellowship of the Royal Academy of Medicine in Ireland.


Infantile pyloric stenosis inheritance, psyche and soma.


Configuration of the beta-carbon atoms of the beta-methyllanthionine residues in nisin.


Workload impact of medical subspecialties in the teaching hospital.


Humanistc studies in U.S. medical education.


The development of an intracerebral glioma model for brain tumor chemotherapy.


Effect of progesterone on the pituitary responsiveness to luteinizing hormone releasing hormone (LHRH) in intact anoestrous ewes.


The gastric tube for esophageal replacement in children.


Correction of total anomalous pulmonary venous drainage in infancy.


Diagnosis of human cardiac allograft rejection by serial cardiac biopsy.


The American Association for Thoracic Surgery 1973-1974.


The influence of Ronald Ropss upon the early development of malaria vector control procedures in the United States Army.


How the computer helps the cardiologist interpret ECG's.


Endotracheal intubation of the newborn.

Endotracheal intubation of the newborn.


Tissue residue studies in swine treated with virginiamycin.


Salmonella typhimurium gastroenteritis. Statewide outbreak.


Hydrostatic sialography. An analysis of a technique.


The epidemiology of learning disorders.

The epidemiology of learning disorders.


Effects of psychopharmacologic agents on learning disorders.


Epidemiological evidence for the fat theory.


Glucose tolerance, plasma lipids and atherosclerosis.


Hardness of drinking-water and cardiovascular disease.


Extrathoracic surgical correction of proximal subclavian and vertebral occlusive disease.


Chronic diarrhea in infants and children. I.


Halothane anesthesia in a burn patient: nine consecutive anesthetics in one having thirty percent second- and third-degree burns.


Megaloblastosis in hematologic malignancy.


Treatment of incontinence secondary to myelodysplasia by an implantable prosthetic urinary sphincter.


Practical pharmacokinetic techniques for drug consultation and evaluation. II. A perspective on the renal impaired patient.


Urinary glucose unreliable as test for urinary tract infection in infancy.


The isolation and sequence analysis of transfer RNA: the use of plaskon chromatography (RPC-5).


The effect of adjuvant arthritis and drugs on the ability of rat plasma to inhibit the triton X-100 induced lysis of rabbit polymorphonuclear leucocyte granules.


The effect of exonuclease I on the transcription of various DNA preparations by rat liver RNA polymerase I and II.


Letters to the editor: Comment on the "caloric catastrophe".


Degradation of transforming Hemophilus influenzae DNA by deoxyribonucleases.


Letter: Caloric recalculation.

Letter: Caloric recalculation.


A clinical trial of inhaled inactivated influenza vaccine.


Spironolactone and frusemide in cirrhosis with ascites.


A new approach for studying the influence of cyclophosphamide upon the rejection of rabbit skin homografts.


Some observations on blood level data following oral administration of aspirin as tablets and capsules.


Modification of the responses of brain stem neurones to transmitter substances by anaesthetic agents. 1. The effects of microiontophoretic applications of acetylcholine (ACh), (-)-noradrenaline ((-)-NA) and 5-hydroxytryptamine (5-HT) have been investigated on spontaneously active brain stem neurones in decerebrate unanaesthetized rats and in rats anaesthetized with either tribromoethanol, urethane or pentobarbitone.2. Four types of responses to both (-)-NA and 5-HT were seen. These were: simple excitation; excitation preceded by a short-lasting inhibition; short-lasting inhibition and prolonged inhibition. Three types of responses to ACh were seen: an excitation with long latency of onset; excitation with short latency of onset, resembling the response to an excitant amino acid, and a short-lasting inhibitory response.3. The types of responses to microiontophoretically applied ACh, (-)-NA or 5-HT in anaesthetized and unanaesthetized animals were similar.4. The number of ACh excitatory responses with short latency of onset were significantly reduced in the pentobarbitone-anaesthetized group and a small but significant increase in the number of 5-HT inhibitory effects were observed in each anaesthetized group of animals.5. A significantly greater proportion of slower firing neurones (less than 10 spikes/s) were found in the pentobarbitone-anaesthetized animals.6. The effects of microiontophoretically applied and i.v. administered pentobarbitone were studied on spontaneously active neurones which responded consistently to ACh and a control agonist.7. Pentobarbitone administered by either route reduced the firing rate of most neurones studied and was shown to antagonize specifically the excitation of neurones by exogenously applied ACh.8. It is suggested that postsynaptic antagonism of endogenously released ACh may be a contributing factor in the mechanism of action of pentobarbitone.


The role of soluble protein factors in the translational control of protein synthesis in eukaryotic cells.


Adenylic acid-rich sequences in messenger RNA from yeast polysomes.


A survey of abscesses in bacon weight pigs.


Isolation and properties of E. coli mutants affected in gluconate uptake.


Control in situ of the pyruvate kinase activity of Escherichia coli.


Complementarily addressed modification of rRNA with p-(chloroethylmethylamino)benzylidene hexanucleotides.


Cardiovascular response to blood withdrawal in the chicken: a "reactive error" in the determination of cardiac output.


Inhibition by lomofungin of nucleic acid and protein synthesis in Saccharomyces cerevisiae.


RNA-binding protein factor in the nuclear extract of rat liver cells.


The functions of immune T and B rosette-forming cells.


Single-stranded RNA synthesis in vitro by the RNA polymerase associated with cytoplasmic polyhedrosis virus containing double-stranded RNA.


Specific elution of tyrosyl-ribonucleic acid synthetase from phospho-cellulose by tyrosine transfer ribonucleic acid.


Biosynthesis of ergosterol in yeast. Evidence for multiple pathways.


Evaluation of a tanned red cell technique for thyroid microsomal antibodies. A haemagglutination test for thyroid microsomal (cytoplasmic) antibodies, using formolized tanned sheep red cells, is described and evaluated. The technique is essentially similar to the thyroglobulin tanned red cell test. It has been shown to be more sensitive and easier to use than the complement-fixation test. A combined screening test to detect both thyroglobulin and microsomal antibodies is described.


Therapy of lipid disorders.

Therapy of lipid disorders.


Group Captain Sir Louis Greig, KBE, CVO.


Secondary hyperlipidaemia.

Secondary hyperlipidaemia.


How do leprosy bacilli leave the body?

How do leprosy bacilli leave the body?


The Hansen Centenary. 1. Hansen, Bergen and leprosy.


Ulcerating lepromatous leprosy in a patient with dapsone-resistant Mycobacterium leprae.


Allograft tolerance: presumptive evidence that serum factors from tolerant animals that block lymphocyte-mediated immunity in vitro are soluble antigen-antibody complexes. Serum factors present in rats rendered operationally tolerant to skin allografts by inoculation of allogeneic bone-marrow cells as newborns inhibit or "block" the cytotoxic effect of immune lymphocytes in vitro. These blocking factors were specifically removed from tolerant serum by absorption with allogeneic cells and later eluted from the absorbing cells in glycine buffer (pH 3.1). Blocking activity of the eluted material was resolved into fractions of low and higher molecular weight, which may be soluble histocompatibility antigen and specific alloantibody, respectively. Both antigen and antigen-antibody complexes may block in vitro, depending upon the assay used.


A purine polyribonucleotide synthetase from Escherichia coli. The isolation, from E. coli B, and partial purification of a purine polyribonucleotide synthetase having several unusual properties is described. The enzyme, which seems to be under strict regulation by several nucleoside triphosphates, requires, after removal of internal primer activity, a primer, such as poly(A), poly(U), or a suitable RNA, but acts without a template. It uses purine ribonucleoside triphosphates as precursors. The uptake of adenylic acid, when ATP is offered alone, is highly stimulated by the presence of GTP, in which case both nucleotides are incorporated into mixed polymers; but GTP as the sole precursor is not utilized. CTP has a strongly inhibitory effect. Other unusual features are the high salt concentration, 0.6 M KCl, at which the enzyme is optimally active and evidence of the existence of a relatively heat-stable protein functioning as an activation factor.


Isolation and characterization of lipopolysaccharide protein from Escherichia coli. Extraction of the cell envelope of E. coli with 1% sodium dodecyl sulfate yielded a lipopolysaccharide protein that was purified to homogeneity by conventional techniques. Analysis of the pure protein indicated that it is a complex lipopolysaccharide protein with the following molar ratios of constitutents: 3-deoxyoctulosonate, 1.0; glucosamine, 1.3; neutral sugar (glucose + heptose), 1.0; organic phosphate, 2.3; and amino acid, 21. On a quantitative basis, all of the 3-deoxyoctulosonate present in the cell envelope preparation was solubilized in hot sodium dodecyl sulfate and subsequently accounted for in its entirely in the isolated protein component. After incubation of the cell-wall particulate fraction of cells grown on [(3)H]glucosamine with UDP-[(14)C]galactose under conditions designed to measure galactosyl transferase activity, the isolated lipopolysaccharide protein contained all of the [(14)C]galactose that was incorporated during the incubation. We concluded that the lipopolysaccharide of this organism occurs in the outer cellenvelope membrane exclusively in the form of lipopolysaccharide protein.


Biosynthesis of transfer RNA: in vitro conversion of transfer RNA precursors from Bombyx mori to 4S RNA by Escherichia coli enzymes. Evidence for the presence of rapidly labeled short-lived RNA species, presumed to be precursors to transfer RNA (tRNA), in the silk glands of Bombyx mori is presented. These precursors, which migrate between 4S and 5S markers on acrylamide gels, can be converted in vitro into molecules indistinguishable in size from tRNA. The conversion is also catalyzed by a crude enzyme fraction isolated from ribosomes of E. coli. Since a similar enzyme preparation cleaves the suppressor tRNA(Tyr) sequence of E. coli from its precursor molecule, it would appear that the precursor to E. coli tRNA(Tyr) and the precursors to silk-gland tRNAs share common structural features.


Discriminatory ribosome rebinding of isolated regions of protein synthesis initiation from the ribonucleic acid of bacteriophage R17. To determine whether bacterial ribosomes recognize a distinguishing feature in the immediate vicinity of actual initiator codons or are directed to these sites through involvement of other portion(s) of the mRNA molecule, the interaction between ribosomes and defined (32)P-labeled initiator fragments from R17 RNA was studied. When incubated with mixtures of the three sites, ribosomes from Bacillus stearothermophilus (which initiate only the A protein on intact phage RNA) are able to select out the A fragment and discriminate against the coat and replicase initiator regions. By contrast, Escherichia coli ribosomes do not rebind that coat-protein region of R17 most efficiently, as they in the native RNA, but likewise prefer the A-protein initiator fragment. In both cases, ribosome binding of the isolated A site is comparable by several criteria to normal polypeptide-chain initiation on an intact R17 messenger RNA in vitro. E. coli ribosomal preference for the A site is confirmed in experiments with randomly fragmented R17 RNA, by both the initiation dipeptide and ribosome protection assay. Thus the A-protein ribosome-binding site of R17 RNA appears intrinsically to be a good initiator, while efficient recognition of the coat and replicase regions requires the participation of some portion of the remainder of the phage RNA molecule.


Cell-free translation of maternal messenger RNA from sea urchin eggs. The template activity of RNA extracted from unfertilized sea urchin eggs was demonstrated in a cell-free translation system, and, for the first time, specific proteins were identified among the products. All messenger RNA activity is recovered, under the conditions used, from the postribosomal supernatant. Histones, among many other proteins, were identified specifically as products of this "maternal" messenger RNA.


Addition of histones to histone-depleted nuclei: effect on template activity toward DNA and RNA polymerases. The ability of histones to block the accessibility of DNA in chromatin to DNA and RNA polymerases was measured by addition of lysine-rich or arginine-rich histones to nuclei selectively depleted of these histones. By this procedure nuclei were obtained in which all of the original lysine-rich histone in the chromatin was replaced by arginine-rich histone. Conversely in other nuclei, additional lysine-rich histone replaced some of the endogenous arginine-rich histone. Lysine-rich histone was much more effective than arginine-rich histone in blocking accessibility to DNA polymerase. Both classes of histone inhibited template activity toward RNA polymerase to a similar extent. In addition to lysine-rich histone and total arginine-rich histone, phosphorylated lysine-rich histone, two fragments of lysine-rich histone produced by cleavage with N-bromosuccinamide, and fractions IIB and IV of arginine-rich histone were added to histone-depleted nuclei. With both DNA and RNA polymerases as probes, no differences in inhibition of template activity were found when native lysine-rich histone was compared to phosphorylated lysine-rich histone. Similarly, fractions IIB and IV were indistinguishable from total arginine-rich histone. On a molar basis, the carboxyl fragment of lysine-rich histone was as effective as intact lysine-rich histone only when the amino fragment was added to it. By itself, the amino portion of lysine-rich histone was without inhibitory effect in the RNA polymerase assay and resulted in only slight inhibition of template activity toward DNA polymerase.


Synthesis and aminoacylation of 3'-amino-3'-deoxy transfer RNA and its activity in ribosomal protein synthesis. 3'-amino-3'-deoxy adenosine was enzymatically converted into 3'-amino-3'-deoxy ATP. This ATP analogue was incorporated into the 3'-terminal adenosine position of Escherichia coli tRNA. The modified tRNA was aminoacylated with phenylalanine by use of E. coli phenylalanyl tRNA synthetase. The phenylalanine was attached to the 3'-amino group of the tRNA, as shown by its high resistance to base-catalyzed hydrolysis in contrast with the normal lability of phenylalanyl-tRNA. Aminoacyl tRNA synthetases charge the 3'-amino-3'-deoxy tRNA with kinetics that are similar to those of the charging reaction in which normal tRNA is the substrate. When phenylalanyl-3'-amino-3'-deoxy tRNA is used in a protein-synthesizing system directed by poly(U) in vitro, this molecule is capable of receiving an acetyl-phenylalanine from the donor site of the ribosome. However, the ribosome is unable to cleave the amide bond connecting phenylalanine to the tRNA molecule; hence, the phenylalanyl-3'-amino-3'-deoxy tRNA has acceptor but not donor activity in protein synthesis. Failure of the ribosome to cleave the amide bond may be due to its greater stability relative to the normal ester bond. However, it may also be due to the fact that the isomerization of the peptidyl chain between the 2' and 3' positions of adenosine is prevented due to the amide bond at the 3' position, and cleavage may normally occur with the peptidyl chain on the 2' position of adenosine.


Criteria for the diagnosis of dermatitis herpetiformis.


Inhibition of transcription of the histidine operon in vitro by the first enzyme of the histidine pathway. An in vitro system was developed for transcription of the histidine operon of Esherichia coli carried in the genome of a defective varphi80 transducing phage. The messenger RNA (mRNA) of the histidine operon synthesized in the in vitro system was detected by hybridization to single strands of both varphi80 and varphi80dhis DNA, and by competition of this hybridization with unlabeled histidine mRNA that had been synthesized in vivo (RNA extracted from cells in which the histidine operon had been derepressed). Under the conditions used, RNA complementary to the histidine operon was about 15% of the total RNA that was synthesized in vitro from the varphi80dhis DNA template. The RNA complementary to the histidine operon was synthesized on the "sense" strand (the R strand) of varphi80dhis in the form of a polycistronic message with a sedimentation coefficient (about 38 S) very close to that observed for the histidine mRNA synthesized in vivo. Synthesis of the histidine operon RNA appears to be subject to control in vitro. Addition of the first enzyme of the pathway for histidine biosynthesis blocked transcription of the histidine operon specifically, strongly suggesting that this enzyme acts as a regulatory protein for the histidine operon.


Transplantation of the coracoid tip: a definitive operation for recurrent anterior dislocation of the shoulder.


Assessment of parasitic infestations by specific immunoglobulin assay.


Plasminogen in the prevention of hyaline membrane disease.


The treatment of idiopathic respiratory distress syndrome using continuous positive airway pressure. A preliminary communication.


In memoriam. Alec Singer.

In memoriam. Alec Singer.


Microvascular surgery in South Africa. II. Operative techniques.


Koch's remedy for tuberculosis.

Koch's remedy for tuberculosis.


Comparative studies on the isolation of salmonella from effluents.


Immunological studies in laboratory animals with enterotoxins from enteropathogenic Escherichia coli strains of porcine origin.


Effect of 1-hydroxymethyl- and 1-methyl-1-aminoalkanes on enzymatic leucine-2-oxoglutarate transamination.


Gastric exfoliative cytology. A rapid method-preliminary report.


Effect of electron donors and acceptors on alcohol dehydrogenase activity during the growth of Escherichia coli.


The aorta-to-coronary radial artery bypass graft. A technique avoiding pathological changes in grafts.


Growth of tracheal anastomoses. An experimental study in weanling pigs.


Diagnosis and reversal of rejection in experimental and clinical lung allografts.


The use of standardized and non-standardized sampling areas in enamel biopsy studies.


Effects of colicin E2 on DNA and the bacterial membrane in vivo.


Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development.


Substrate protection during selective heat inactivation of aminoacyl-tRNA synthetases and its use in enzyme studies.


Origin and direction of chromosome replication in Escherichia coli K12.


Rotational relaxation of macromolecules determined by dynamic light scattering. II. Temperature dependence for DNA.


Incorporation of 5-methyltryptophan into the protein of Escherichia coli.


Observations of self-aggregation and dissociation of E. coli ribosomes by optical mixing spectroscopy.


A conservative surgical approach to the correction of irritational hyperplasias caused by dentures.


Stereotactic limbic leucotomy: neurophysiological aspects and operative technique.


Stereotactic limbic leucotomy: a preliminary report on forty patients.


Visual interaction in psychiatric patients: a review.


Psychological studies of ten patients with the XYY syndrome.


Haloperidol in the treatment of stutterers.


The prevention of postoperative deep venous thrombosis with dextran 70.


A sterile 'use-once' clip applicator for skin closure.


The management of villous tumours of the large bowel.


Double-blind trial to compare two dosages of co-trimoxazole in the treatment of hospital infections.


Electrical response of retinal cells as a sign of transport.


Absorptive transport of prostaglandins from intraocular fluids to blood: a review of recent findings.


Cerclage in the treatment of the incompetent cervix.


Urinary diversion in children.

Urinary diversion in children.


Dr. Still and Mark Twain.

Dr. Still and Mark Twain.


Effects of sublethal irradiation on the plaque-forming cell response in mice.


T cell deficiency in mouse allogeneic radiation chimeras.


Heart autoantibodies in mice: genetic, bacterial, and age determinants.


The skeletal muscle binding site of antistriated muscle antibody in myasthenia gravis: an electron microscopic immunohistochemical study using peroxidase conjugated antibody fragments.


Selective cytotoxicity of hapten-substituted cells with an antibody-enzyme conjugate.


Reversibility of the immunodepression due to Ehrlich ascites carcinoma.


Influence of the tripeptide, PRO-ARG-GLY-(NH2), on ovulation induced with LH or synthetic LH-FSH releasing hormone in chlorpromazine-treated pro-oestrous rats.


Nuclear medicine in neurological diagnosis.


Australia's first medical library.

Australia's first medical library.


Anthony Hawthorne Sheehan.

Anthony Hawthorne Sheehan.


The nature of the transformation process in Escherichia coli K12.


Mapping of fabC, a locus for the biosynthesis of unsaturated fatty acids in Escherichia coli K12.


A mutant of Escherichia coli K12 deficient in the 5'-3' exonucleolytic activity of DNA polymerase I. II. Purification and properties of the mutant enzyme.


Reticulum cell sarcoma complicating dermatitis herpetiformis.


English private madhouses in the eighteenth and nineteenth centuries.


Edward Jenner.

Edward Jenner.


Historical aspects of Vincent's disease.


Cannabis and its problems.

Cannabis and its problems.


The "isolation syndrome" in mice.

The "isolation syndrome" in mice.


Ocular complications in rheumatic disorders.


Synovitis of the knee treated by intra-articular hydrocortisone acetate, hydrocortisone acetate plus saline, or saline alone. A double-blind trial.


Double-blind cross-over study of Orudis and placebo in fifty patients with rheumatoid arthritis.


Double-blind comparison of ibuprofen and phenylbutazone in the short-term treatment of rheumatoid arthritis.


Serological studies on general paralysis of the insane.


Autoradiographical and morphological evidence for apocrine secretion of dipalmitoyl lecithin in the terminal bronchiole of mouse lung.


RNA in the in vitro immune response. Flow of information and gene activation during antibody synthesis.


Discussion paper: studies on the differentiation within the immune system.


Phenothiazine effects in good premorbid schizophrenics divided into paranoid-nonparanoid status.


A computer interview for psychiatric patient target symptoms.


A reappraisal of psychiatry in the Middle Ages.


Corneel Heymans. A collective biography.


The First Heymans Memorial Lecture, Ghent, March 24, 1972. Some aspects of the actions of prostaglandins.


PMR studies of the substrate induced conformational change of glutamine binding protein from E. coli.


Ribonucleotides in closed circular mitochondrial DNA from HeLa cells.


Phosphorus-31 relaxation rate studies of Mn 2+-alkaline phosphatase.


Repair deficiency in Escherichia coli UV-sensitive mutator strain uvr502.


Involvement of 50S ribosomal proteins L6 and L10 in the ribosome dependent GTPase activity of elongation factor G.


Separation of RNA polymerase holoenzyme from core enzyme on DNA-cellulose column.


The establishment of the elastic structure of arterial bifurcation and branches. Its relevance to medial defects of cerebral arteries.


Optimal conditions for primer-dependent transcription of poly (dT) by RNA polymerase.


Reactions at the 3' terminus of transfer ribonucleic acid. IX. tRNA nucleotidyltransferase activity in bacteriophage T4-infected Escherichia coli.


Total synthesis of hypothalamic "somatostatin".


Stereospecificity of ethanol oxidation.

Stereospecificity of ethanol oxidation.


Identification of the iodine-sensitive tyrosines in porcine pepsin.


Spheroidal bodies and globi of human leprosy.


Properties of elongation factor G: its interaction with the ribosomal peptidyl-site.


Protective effects of propranolol on isoproterenol-induced myocardial infarction in arteriosclerotic and non-arteriosclerotic rats.


Some actions of growth hormone release inhibiting factor. Preliminary studies indicate that somatostatin (SRIF, somatropin release inhibiting factor) can suppress exercise-induced plasma growth hormone rise in normal subjects as well as in diabetics.


Consumer reaction: a patient's view of hospital life in 1809.


Kidney donation and the law.

Kidney donation and the law.


J. L. D'Silva.

J. L. D'Silva.


Brevel-Colonel Sir Ram Nath Chopra.

Brevel-Colonel Sir Ram Nath Chopra.


Colonel K. McNeill.

Colonel K. McNeill.


O.J. Macdonald.

O.J. Macdonald.


Treatment of cardiogenic shock. II.

Treatment of cardiogenic shock. II.


The resistance of cysts of Stictodora lari (Trematoda: Heterophyidae) to encapsulation by cells of the fish host.


Genetic variation in neuromuscular performance.


The nasal septum in repairing surgical defects of the palate.


Demonstration and characterization of an epidermal angiogenic factor.


Hypnotically induced dreams using the Rorschach inkblots as stimuli: a test of Freud's theory of dreams.


A comparison of the psychological adjustment of obese vs. non-obese children.


The effect of maternal immunity on the survival of goat x sheep hybrid embryos.


On transfer times in tracer experiments.


Implications of stochastic inheritance.

Implications of stochastic inheritance.


Serological tests on L-phase variants of some bacteria.


Characteristics of the primary structure of fungal DNA.


Transfer RNA and aminoacyl-tRNA synthetases in cells of E. coli infected with phage MS2.


Estimation of the blood flow through a peripheral organ (kidney) using the technique of isotope dilution after i.v. injection in animal experiments.


The discipline of toxicology: its future in training and research.


Investigation of the partial dissociation of glutamate decarboxylase of E. coli.


Microscale ion-exchange chromatography and spectral analysis of oligonucleotides.


Isolation and characterization of valine transfer ribonucleic acids.


Structure of the gall bladder in some freshwater telecosts.


On the nature of cell divisions adjacent to electrolytic lesion in the brain of marsh-frog (Rana ridibunda Laur).


Postoperative wound infection: prediction of some responsible organisms.


Bilateral nephrectomy in chronic hemodialysis and renal transplant patients.


An automated determination of ratios of type 2 pneumocytes to alveolar wall area using an image analyzer.


Circulating cytotoxic lymphocytes in human tuberculosis.


Inactivation of staphylococci by alveolar macrophages with preliminary observations on the importance of alveolar lining material.


Protective efficacy of killed Mycoplasma pneumoniae vaccine measured in large-scale studies in a military population.


Nocardia asteroides. A taxonomic study with clinical correlations.


Aspergilloma consequent to allergic bronchopulmonary aspergillosis.


Mycobacterium xenopi and mycobacteriosis. A clinical bacteriologic report.


Cytoplasmic hepatitis B antigen in "ground-glass" hepatocytes of carriers.


Purification of two populations of human alveolar macrophages from surgical specimens.


Isoantigens A, B, and H in carcinoma of the fallopian tube.


Lipase activity in E. coli.

Lipase activity in E. coli.


Fluorometric measurements on the interaction of melittin with lecithin.


Antiheart antibody in idiopathic hypertrophic subaortic stenosis.


Synergistic effects of diethylnitrosamine and different dusts on respiratory carcinogenesis in hamsters.


Influence of apurinic acid on programmed synthesis in different in vitro systems.


Regression of transplantable immunoglobulin-secreting rat tumors by irradiation and chemotherapy and induction of transplantation resistance.


Intravasal stents for vasovasostomy in canine subjects.


Accessories & warranties.

Accessories & warranties.


Disposable electrosurgical active handles.


Disposable electrosurgical return electrodes.


Use of electrosurgical gels.

Use of electrosurgical gels.


Merthiolate and aluminum electrodes.

Merthiolate and aluminum electrodes.


Recent design changes in disposable return electrodes.


Richards Shea stapes drill.

Richards Shea stapes drill.


Psychiatric disorders in a community mental health center. I. Demography and diagnoses.


Role of immunoconglutinin in resistance to infection. The in vitro promotion of phagocytosis by immunoconglutinin.


Fate of skin allografts in normal mice injected with antigraft strain globulin in relation to the IgG1 and IgG2 class of the antibodies.


Sensitization to human lymphocyte antigens by corneal transplantation.


Immunologic protection of rabbit corneal allografts: preparation and in vitro testing of heterologous "blocking" antibody.


The normal surface of corneal epithelium: a scanning electron microscopic study.


Immunologic mechanisms in hypersensitivity pneumonitis. I. Evidence for cell-mediated immunity and complement fixation in pigeon breeders' disease.


Granulocytic leukemia in whitehanded gibbons.


Myocardial abscesses in a brown pelican.


Capacitation of golden hamster spermatozoa during incubation in culture medium.


The fertilizing life of spermatozoa in the cauda epididymidis of mice and hamsters.


Rapid bacteriological identification of uropathogens.


Clinical evaluation of a radiopaque composite restorative material after three and a half years.


The urine culture pipet: a simple inexpensive method for bacteriuria quantitation.


Clinical evaluation of testing immediate antibiotic disk sensitivities in bacteriuria.


Editorial: Surgical treatment of mitral stenosis: a medical milestone.


Stress distribution in photoelastic models of transverse sections of porcelain-fused-to-gold crowns and preparations.


Editorial: Maxwell Finland, distinguished physician.


Letter: Cytochemical diagnosis.

Letter: Cytochemical diagnosis.


Epidemiologic, clinical and laboratory aspects of wound botulism.


Effect of stannous fluoride on recurrent caries--results after 24 months.


Control of ribosomal RNA synthesis in vitro.


Letter: Electron-dense particle in cholinergic synaptic vesicles.


Pathologically altered fibroblasts within lymphoid cell infiltrates in early gingivitis.


Letter: Action of heparin on nuclei: solubilization of chromatin enabling the isolation of nuclear membranes.


Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan.


Letter: Effects of light intensity, wavelength and quanta on gonads and spleen of the deer mouse.


Letter: Experimental arthritis in thymectomized rats with an impaired humoral immune response.


Letter: Fusion of two immunoglobulin-producing myeloma cells.


Letter: Why is the XX fitter? Evidence consistent with an effect of X-heterosis in women from sex ratio data in offspring of first cousin marriages.


Letter: Photoperiodism and adaptive behaviour in a small mammal.


Letter: Visual pigment of the giant panda Ailuropoda melanoleuca.


Letter: Bacterial endotoxins in the environment.


Letter: Formation of molecular nitrogen by a burning cigarette.


Letter: Grammar of a movement sequence in inbred mice.


Letter: Asymmetry in gorilla skulls: evidence of lateralized brain function?


Letter: Perceptual structure of the necker cube.


Effect of actinomycin D on DNA synthesis in liver.


Inhibition of rat liver RNA synthesis by aflatoxin B.


Mechanical instability of the oxy-form of sickle haemoglobin.


The regulation of vitamin D metabolism.

The regulation of vitamin D metabolism.


Localization and release of glutamic acid in relation to the hippocampal mossy fibre pathway.


Pattern of remyelination in the CNS.

Pattern of remyelination in the CNS.


Tolerance of Sk-incompatible skin grafts.


Sulphate conjugation and L-dopa treatment of Parkinsonian patients.


Isolation of a factor from human seminal plasma that promotes fertilization.


Zirga virus, a new arbovirus isolated from bird-infesting ticks.


Form and role of deformation in excitation of an insect mechanoreceptor.


Potent pyrethroid insecticides from modified cyclopropane acids.


Experimental model for production of perforating duodenal ulcers by cysteamine in the rat.


Rapid nitrosation of phenols and its implications for health hazards from dietary nitrites.


Tissue-specific sorting-out in two dimensions in relation to contact inhibition of cell movement.


Hapten-specific helper effects in antibody formation.


Test of selection and neutrality in natural populations.


Why is the XX fitter? Evidence consistent with an effect of X-heterosis in the human female from sex ratio data in offspring of first cousin marriages.


Number of gene loci required for accurate estimation of ancestral population proportions in individual human hybrids.


Model for evolutionary origin of chromosome bands.


Nitrogen fixation in termites.

Nitrogen fixation in termites.


Correspondence: Infant precocity.

Correspondence: Infant precocity.


Letter: Temporal allelic interaction, a new kind of dominance.


Letter: Sex-associated differential fluorescence of mudminnow chromosomes and spermatozoa.


Letter: Low and high affinity antibodies can alternate during the immune response.


Letter: Collagen of Marfan syndrome is abnormally soluble.


Letter: Ethanol oxidation by human erythrocytes.


Letter: Smoking, pregnancy and publicity.


Letter: Smoking and pregnancy.

Letter: Smoking and pregnancy.


The dorsal nasal flap.

The dorsal nasal flap.


The flag flap.

The flag flap.


Bone grafting of skull defects. A report on 55 cases.


Management of hand infections in the narcotic addict.


Rejection phenomena after homotransplantation of skin flaps in dogs by microvascular technique.


Use of commercial porcine skin for wound dressings.


The use of a drum dermatome in reduction mammaplasty.


National societies of plastic surgery. (Members of the international confederation).


The use of photon absorptiometry in the diagnosis of renal osteodystrophy.


Arthrography of total hip replacement using subtraction technique.


Aloys George Ansprenger, M.D. 1905-1972.


Austin John Brogan, M.D. 1905-1972.

Austin John Brogan, M.D. 1905-1972.


Simultaneous electrophoresis of pepsinogens and pepsins.


Subcellular distribution and fate of radioactivity in ovaries of pseudo-pregnant rats after in vivo administration of (131-I)HCG.


Adaptation of the gastric mucosa to repeated administration of aspirin in the rat.


Pierre Louis: the numerical method and the foundation of quantitative medicine.


APHA and the affiliates.

APHA and the affiliates.


The role of the phagocyte in host-parasite interactions. XXXIX. Stimulation of bactericidal activity of myeloperoxidase-containing leukocytic fractions by estrogens.


Editorial: Francis L. Lederer, MD, 1898 TO 1973.


Posterior and complete laryngeal (glottic) stenosis.


Nephrosis of Hodgkin disease. An immune complex-induced lesion.


The interaction of inter-trial intervals, timing of surgery and differential hippocampal lesions.


A test of Piaget's explanation of the Müller-Lyer illusion.


H.R. McAleenan.

H.R. McAleenan.


Editorial: The point of the Lancet.

Editorial: The point of the Lancet.


Urinary tract diseases.

Urinary tract diseases.


Letter: Risks of small dentures.

Letter: Risks of small dentures.


Proprietary nursing homes in New York City: some notes on services, payment, patients, and regulation.


Dissection and discrimination: the social origins of cadavers in America, 1760-1915.


Medical numismatic notes, 13: Benvenuto Cellini and the Duke's curls.


Some early demographic maps.

Some early demographic maps.


A case of "cold" white kidney.

A case of "cold" white kidney.


Clinical evaluation of 1,3-bis(2-chloroethyl)-nitrosourea (BCNU; NSC-409962) with fluoxymesterone (NSC-12165) in the treatment of solid tumors.


Long-term therapy of Parkinson's disease with amantadine, alone and combined with levodopa. A dual study was conducted to assess (1) the long-term antiparkinsonian action of amantadine without levodopa and (2) the advantage of combined amantadine and levodopa over single-drug therapy, including changes in symptom severity when placebo replaces amantadine but levodopa is maintained.Good to excellent results were obtained in 25% of the total pool of 77 patients on amantadine. No decline in therapeutic effect took place during a mean follow-up of 21 months.Thirty-seven patients with considerable residual deficit after single-drug therapy derived improvement from the second drug (levodopa or amantadine). Gains in neurological signs and activities of daily living (ADL) ranged between 50 and 60% and for timed skills close to 25%. Depending on the individual indices, between 64 and 100% of patients improved with the second drug.Placebo instead of amantadine produced deterioration. There was 75% loss in ADL, 45% loss in timed skills and losses in neurological signs exceeded gains produced by two-drug therapy.


Escalator injuries of the hand.

Escalator injuries of the hand.