Fetal renal structure and the genesis of amniotic fluid disorders. Newborn recipient twins in the transplacental transfusion syndrome have dilated renal tubules, enlarged bladders and an increased urinary output in the early neonatal period, suggesting that increased fetal micturition is responsible for hydramnios in the syndrome. There is the possibility that such micturition contributes to hydramnios in other disorders as well. In the present study, renal tubules were found to be dilated in single-born infants with a diverse group of disorders having hydramnios as a common feature. Many of the neonates had hypoplastic lungs, an abnormality whose role in the hydramnios is undetermined. Renal tubular lumina were of normal size in neonates associated with oligohydramnios due to chronic leak of amniotic fluid. Donor members of parabiotic transplacental transfusion pairs had contracted renal tubules which helps to explain their oligohydramnios.


Use of a mobile transplant kidney preservation unit in a large metropolitan area.


Reduction of pepsin activity by bile. A factor favoring ulcer formation after bile-diverting operations.


Renal homotransplantation in children.

Renal homotransplantation in children.


Clinico-pharmacological studies and clinical evaluation of flurbiprofen. A new non-steroidal antirheumatic agent.


Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase: binding of the folate substrate to the enzyme.


Topical treatment with BAY b 5097, a new broad spectrum antimycotic agent.


A review of the recent literature on diseases of the vulva. I. General aspects.


Dyserythropoiesis and dyserythropoietic anaemia.


Cancer of the lip at risk.

Cancer of the lip at risk.


Treatment of aphthous ulceration with topical azathioprine. A double blind trial.


In memoriam. Charles K. Friedberg, M.D.

In memoriam. Charles K. Friedberg, M.D.


Pulmonary edema. The water-exchanging function of the lung.


Effects of neutral red on blood glucose, NEFA and pancreatic alpha-cells in rats.


Tyrosyl-tRNA synthetase from baker's yeast. Isolation and some properties.


A kinetic model for the action of the inorganic pyrophosphatase from bakers' yeast. The activating influence of magnesium ions.


Use of immunologically modified bacteriophage T4 in detection of antibodies to nucleic acids.


Plasma concentrations of propoxyphene in man. I. Following oral administration of the drug in solution and capsule forms.


Dysphoric symptoms in chronic alcoholics and the effect of carbamazepine (Tegretol).


Doxepin in the treatment of hospitalized and ambulatory psychoneurotic patients.


Cytoplasmic particles in hepatocytes of patients with Australia antigen-positive liver disease. An electron microscope study was made of liver biopsy material obtained during life or shortly after death from 11 patients. In three of them, where serum was positive for Australia antigen (two had serum hepatitis and one active chronic hepatitis) the hepatocytes contained characteristic particles within membrane-bound cytoplasmic vesicles. The appearance of these particles was very similar to that of the Australia antigen particles found in the serum. Two sizes of cytoplasmic particles were observed, with average diameters of about 26 and 46 nm. Particles of both sizes often had a membrane-like outer component and a moderately electron-dense inner component. They differed in both size and structure from the mainly intranuclear particles described by previous authors and which were not found in the present patients. The nature of the vesicles containing the particles was not apparent.


A comparison of the absorbed fluorescent treponemal antibody (FTA-ABS) test and other screening tests for treponemal disease in patients attending a venereal disease clinic. Screening tests-absorbed fluorescent treponemal (FTA-ABS), the Reiter protein complement-fixation (RPCFT), VDRL slide test, automated reagin-and cardiolipin Wassermann reaction-were carried out on 1922 consecutive new patients attending the Whitechapel Clinic over a three-month period.Taking the FTA-ABS test results as an index, the most efficient combination of conventional tests was found to be the RPCFT and automated reagin test. The cardiolipin WR proved to be under-sensitive and of little value compared with the other tests.Forty-two per cent of the 107 sera reactive in the FTA-ABS test were not detected by the RPCFT or ART tests. An assessment based on the TPI test results and clinical findings in these patients is presented. The scope and limitations of the FTA-ABS test as a screening procedure are discussed.


A solid medium for visual demonstration of coagulase production by Staphylococcus aureus.


Lysis of red cells from haematological disorders.


Estimation of serum and urinary muramidase with the eel aggregometer.


A review of the central response to peripheral nerve injury and its significance in nerve regeneration.


Multiple extracranial vessel injuries frollowing closed head and neck trauma. Case report.


Successful evacuation of acute pontine hematoma. Case report.


Treatment of multiple intracerebral cryptococcal granulomas with 5-fluorocytosine. Case report.


Monoamine oxidase inhibitors.

Monoamine oxidase inhibitors.


Biological implications of molecular and crystal structures of sulfadimethoxine, sulfadoxine, and sulfisoxazole.


Changes in the luteinizing hormone-releasing factor (LH-RF) content of the hypothalamus of the sheep during the oestrous cycle.


Inotropic responses of the left ventricle to changes in aortic arch pressure in anaesthetized dogs. 1. Inotropic changes in the left ventricle in chloralose anaesthetized dogs were determined in response to changes in non-pulsatile pressure perfusing the vascularly isolated aortic arch.2. Inotropic responses were assessed by measuring the maximum rate of change of left ventricular pressure (dP/dt max) in preparations in which heart rate, mean ascending aortic pressure and brachiocephalic (i.e. carotid sinus and cerebral) perfusion pressure were held constant.3. dP/dt max increased (average +43%) when aortic pressure was reduced from a level above that which produced maximum depression of the myocardium to a level below which no further responses could be obtained; responses occurred as aortic arch pressure was changed between 250 and 90 mm Hg.5. In the same preparations changes in the brachiocephalic artery perfusion pressure with aortic arch pressure held constant resulted in similar inotropic responses.6. It is suggested that aortic arch baroreceptors may be of importance in the control of the inotropic state of the heart.


Bridge formation between mouse peritoneal macrophage-macrophage and macrophage-lymph node cells and the influence of various chemicals.


Defective gene product in dnaF mutant of Escherichia coli.


[Mutant tRNA His  ineffective in repression and lacking two pseudouridine modifications].


Phage DNA directed enzyme synthesis in vitro system from yeast mitochondria.


Cell interactions in humoral and cell-mediated immunity.


Pneumothorax complicating treatment of laryngeal spasm.


Naval surgery in War of 1812.

Naval surgery in War of 1812.


Freud's views on current psychotherapeutics?


The immunopathogenesis of schistosomiasis: a multidisciplinary approach.


A study of Title 19 coverage of abortion.


Recent advances in uveitis.

Recent advances in uveitis.


Electron microscopic studies of corneal endothelium: the abnormal endothelium associated with retrocorneal membrane.


Spatial relations in the oral cavity and the mechanism of secondary palate closure in the rat.


Renal transplantation from cadavers.

Renal transplantation from cadavers.


Effect of synthetic luteinizing hormone releasing hormone (LH/FSH-RH) in women with menstrual disorders. Synthetic luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) (50 mug) was given intravenously to six women with oligomenorrhoea and to four women with secondary amenorrhoea. Peripheral venous blood was withdrawn at regular intervals over a 24-hour period. The concentrations of LH, FSH, and oestradiol-17beta were determined by radioimmunoassay. In all subjects there was a variable rise in LH (3-16 times the mean basal level): in six a small rise in FSH (two to three times the mean basal level) and in seven a twofold to threefold rise in oestradiol three to eight hours after the rise in gonadotrophins.


Chloramphenicol resistance in the typhoid bacillus. Chloramphenicol resistance has been reported in individual strains of Salmonella typhi since 1950, but there had been no accounts of epidemics caused by resistant strains of the organism until 1972, when one occurred in Mexico. Two British patients have been infected in that country, and the organism isolated from them corresponds in all respects with the description of the Mexican epidemic strain of S. typhi: it is a degraded Vi strain resistant to chloramphenicol, streptomycin, sulphonamides, and tetracyclines. It owes its resistance to an R factor which can be transferred to Escherichia coli and thence to drugsensitive S. typhi. Although there is a negligible risk of dissemination of this strain in Britain the incident is a reminder of the need to restrict the use of drugs such as chloramphenicol to the serious diseases for which they are virtually specific.


Streptococcal sore throat.

Streptococcal sore throat.


A simple method of replacing broken or worn precision attachments.


Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction. This paper describes a double-bond crossover trial of prednisolone and beclomethasone dipropionate aerosol in 38 steroid-dependent patients with reversible diffuse airways obstruction. Altogether there was no difference in the patient's preference of the two treatment groups or in the number of times they used their bronchodilator aerosol, or in the forced expiratory volume in one second, vital capacity, or peak expiratory flow rate in the two treatment groups. The plasma cortisol levels when the patients were on the aerosol were much higher than when they were on prednisolone. The use of inhaled aerosol steroids seems to be preferable as it eliminates the usual complications of oral steroid therapy.


Robert M. Stecher, MD.

Robert M. Stecher, MD.


Primary lymphosarcoma and reticulum cell sarcoma of skin. A review of thirty-two cases.


Isolation of plaque-forming, galactose-transducing strains of phage lambda. Plaque-forming, galactose-transducing lambda strains have been isolated from lysogens in which bacterial genes have been removed from between the galactose operon and the prophage by deletion mutation.-A second class has been isolated starting with a lysogenic strain which carries a deletion of the genes to the right of the galactose operon and part of the prophage. This strain was lysogenized with a second lambda phage to yield a lysogen from which galactose-transducing, plaque-forming phages were obtained. These plaque-forming phages were found to be genetically unstable, due to a duplication of part of the lambda chromosome. The genetic instability of these partial diploid strains is due to homologous genetic recombindation between the two identical copies of the phage DNA comprising the duplication. The galactose operon and the duplication of phage DNA carried by these strains is located between the phage lambda P and Q genes.


On some genetic aspects of phage lambda resistance in E. coli K12. Most mutations rendering E. coli K12 resistant to phage lambda, map in two genetic regions malA and malB.-The malB region contains a gene lamB specifically involved in the lambda receptor synthesis. Twenty-one independent lamB mutations studied by complementation belonged to a single cistron. This makes it very likely that lamB is monocistronic. Among the lamB mutants some are still sensitive to a host range mutant of phage lambda. Mutations mapping in a proximal gene essential for maltose metabolism inactivate gene lamB by polarity confirming that both genes are part of the same operon. Because cases of intracistronic complementation have been found, the active lamB product may be an oligomeric protein.-Previously all lambda resistant mutations in the malA region have been shown to map in the malT cistron. malT is believed to be a positive regulatory gene necessary for the induction of the "maltose operons" in the malA region and in the malB region of the E. coli K12 genetic map. No trans dominant malT mutation have been found. Therefore if they exist, they occur at a frequency of less than 10(-8), or strongly reduce the growth rate of the mutants.


Nonsense mutations in the ade3 locus of Saccharomyces cerevisiae. Fifty seven mutations at the ade3 locus have been crossed to ochre, amber and ochre-amber suppressors. 70% (39/56) of the mutations at this locus are nonsense mutations; 61% (34/56) are ochre mutations and 9% (5/56) are amber mutations. The frequency of nonsense mutations among ade3 alleles recovered is very high and raises the interesting possibility that only polar mutations at this locus are recovered. An hypothesis to explain these genetical findings as well as physiological properties of these mutations is proposed.


Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Alleles at the agouti locus in the mouse determine the synthesis of either phaeomelanin or eumelanin by follicular melanocytes by altering the hair follicle environment. The method of dermal-epidermal recombination of mouse skin from C57BL/6J a/a and C57BL/6J A(w-J)/A(w-J) embryos was used in this study to establish the precise site of agouti gene action within the hair follicle. The pigmentary pattern of hairs formed in the recombination skin grafts was specific for the genotype of the dermal (mesodermal) component of the hair follicle. The genotype of the epidermal (ectodermal) component had no influence on the type of hair pigmentary pattern. These results indicate that future studies on gene mechanisms should focus on the dermis as the determining factor in altering the hair follicle environment.


A method for obtaining antibiotic-sensitive mutants in Saccharomyces cerevisiae. We have isolated a temperature-sensitive mutant of S. cerevisiae which has proven useful for the isolation of antibiotic-sensitive strains.


Solar and senile skin: changes caused by aging and habitual exposure to the sun.


U.S. acts to ease doctor problems with medicare.


The pharmacologic approach to the treatment of shock. II. Diagnosis of shock and the plan of treatment.


On the presentation of the Friedenwald award in ophthalmology to Dr. Alan M. Laties.


Remarks on the acceptance of the Friedenwald award.


"BCG"-vaccine studies suppurative lymphadenitis following intradermal B.C.G. vaccination of the newborn.


Toxoplasma serologic survey on hepatitis patients.


A bibliography of doctoral dissertations on aging from American institutions of higher learning, 1969-1971.


Human heart transplantation.

Human heart transplantation.


Human heart transplantation--today and tomorrow.


In memoriam: Dr. J.B. Chatterjea, M.D., F.N.A., F.R.C. Path. (Lond.),F.A.C.P. (Cor.), F.A.M.S.


1972-73 membership roster. Southern California dental association.


Dr. K.P. Sengupta.

Dr. K.P. Sengupta.


Dr. B.B. Yodh.

Dr. B.B. Yodh.


A programmed course in histopathology: design and use.


Isolation, identification and synthesis of a specific-behaviour-inducing brain peptide.


Restricted host range of a feline leukaemia virus.


Comments on the chemistry of scotophobin.


Loss of DDT from storage in human body fat.


Gravitational separation of X and Y spermatozoa.


Reduced monoamine oxidase activity in blood platelets from schizophrenic patients.


Genetic studies of sleep in mice.

Genetic studies of sleep in mice.


Visual-auditory distance constancy.

Visual-auditory distance constancy.


Visual-auditory distance constancy. Reply to Engel and Dougherty.


Telescope prostheses. Case report.

Telescope prostheses. Case report.


Complete mouth rehabilitation of malocclusion brought about by parafunctions.


Rational impression technique for precision casting.


Verbal communication.

Verbal communication.


1972 WSDA directory.

1972 WSDA directory.


Effect of antiserum on peripheral blood lymphocyte.


Supply and utilization of acetate in mammals.


Dissociation of the obesity-hyperinsulinism relationship following dietary restriction and hyperalimentation.


Analysis of sterols: application to sterol balance studies.


Development, aging, and life duration: effects of nutrient restriction.


Maternal undernutrition and its long-term effects on the offspring.


Physiological aspects of aging: relationship to nutrition.


The effect of pH on the binding and acceptor sites of intrinsic factor.


Current knowledge of diverticular disease of the colon.


Pancreatic function in patients with Zollinger-Ellison syndrome. Observations concerning acid-bicarbonate secretion ratios.


Effects of blood volume and atrial stretch on hypothalamic single-unit activity.


The prostaglandins. Biochemical, physiologic and clinical considerations.


EEG synchronization following application of serotonin to area postrema.


d-c Potential difference between different cerebrospinal fluid sites and blood in dogs.


Pepsin secretion by Heidenhain pouches in dogs.


Microelectrophoresis of cholinergic and aminergic drugs on paraventricular neurons.


Renal transplantation in children. Analysis of 25 consecutive transplants in 19 recipients.


Creatine phosphokinase (CPK) in the CSF: its value in the management of children with myelomeningocele and hydrocephalus.


Use of the 'Gregory box' (CPAP) in treatment of RDS of the newborn: preliminary report.


Maternal nutrition and prenatal growth. Experimental studies of effects of maternal undernutrition on fetal and placental growth.


Pulmonary fibroplasia in newborn babies treated with oxygen and artificial ventilation.


Experience with a catheter-tip transducer for continuous measurement of blood oxygen tension, including evaluation in 4 newborn babies.


Possible role of lysosomal enzymes in the pathogenesis of periodontitis: a study on cathepsin D in human gingival fluid.


Cultivation of Saccharomyces cerevisiae in continuous culture. II. Influence of the crabtree effect on the growth characteristics of Saccharomyces cerevisiae grown in a glucose limited chemostat.


Intermittent sucrose feeding and caries in hamsters.


Development of an in-vitro plaque model from human salivary sediment suspensions.


Enuresis and psychoactive drugs.

Enuresis and psychoactive drugs.


A controlled clinical trial of trimipramine and placebo in the treatment of enuresis.


A double-blind comparative trial of aspirin preparation and ibuprofen in general practice.


Commentary on "Use of hydrocortisone in the treatment of acute myocardial infarction".


The rib spreader: a chapter in the history of thoracic surgery.


Kinetics and mechanisms of drug action on microorganisms. XIV. The action of fluorouracil, other uracils and derived nucleosides on the microbial kinetics of Escherichia coli.


Rifampicin blood serum levels and half-life during prolonged administration in tuberculous patients.


Editorial comment on "The use of hydrocortisone in the treatment of acute myocardial infarction".


Rapid identification of psychopharmacologic agents in cases of drug abuse.


The immunogenic components of equine anti-human lymphocyte lobulin in renal allograft recipients.


Immunofluorescent studies on human spermatozoa. 3. Immunoglobulin classes of human spermatozoal antibodies.


Current operations for duodenal ulcer.

Current operations for duodenal ulcer.


Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica.


Eye movements induced by stimulation of the pontine reticular formation: evidence for integration in oculomotor pathways.


Unimodal and multimodal response properties of neurons in the cat's superior colliculus.


Modification of unit discharges in the medial geniculate nucleus by click-shock pairing.


Cortically induced changes of presynaptic excitability in higher-order auditory afferents.


Trypanosoma lewisi: influence of sera and peritoneal exudate cells.


Trypanosoma congolense: fine structure study by the carbon replica and freeze-etch technique.


Caryophyllidea (Cestoidea): a review.

Caryophyllidea (Cestoidea): a review.


Dietary sugars and intestinal enzymes.

Dietary sugars and intestinal enzymes.


Ultrastructural changes in experimental allergic orchitis in guinea-pigs.


Glucose-6-phosphate dehydrogenase deficiency--a genetic disorder of red cell metabolism.


Response of drug-resistant Plasmodium falciparum to combined therapy in Panama.


Preliminary studies on a Philippine strain of Plasmodium falciparum resistant to amodiaquine.


Serological indices in Tanzania. II. Antinuclear factor and malarial indices in populations living at different altitudes.


The researches of Dr. Martinus van Marum (1750-1837) on the influence of electricity on animals and plants.


'This living hand'.

'This living hand'.


The 1832 cholera epidemic in York.

The 1832 cholera epidemic in York.


Benjamin Gooch, eighteenth-century Norfolk surgeon.


The development of blood gas analysis.

The development of blood gas analysis.


A medieval glorification of disease and death.


Some letters of Dr. Thomas Willis (1621-1675).


Pharmaceutical history and its sources in the Wellcome collections. IV. Tiles, pills and boluses.


Portraits of Hippocrates.

Portraits of Hippocrates.


Comparison of nitrate reductase mutants of Escherichia coli selected by alternative procedures.


Regulation of the synthesis of aspartokinase 3 of Escherichia coli by amino acids other than lysine.


Vegetative recombination of bacteriophage Mu-1 in Escherichia coli.


Mutator activity in uvs mutants of Aspergillus nidulans.


Photosensitization of Col Ib factor by 5-bromodeoxyuridine.


Population screening by the cervical smear.


Servo action in human voluntary movement.


Immunogenic effects of foreign materials on plasma proteins.


Demonstration of carcinoembryonic antigen in normal human plasma.


Persistent infection of human lung cells with influenza virus.


Persistence of methadone-3H and metabolite in rat brain after a single injection and its implications on pharmacological tolerance.


Aspirin prevents the disruption of the blood-aqueous barrier in the rabbit eye.


2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine hydrochloride, a potential psychotropic agent.


Scanning electron microscope study of Jane Austen's hair.


Variation in lead concentration along single hairs as measured by non-flame atomic absorption spectrophotometry.


Mercury in marine organisms of the Tay region.


Lead pollution from a factory manufacturing anti-knock compounds.


Population differentiation in Marchantia polymorpha L. in various lead pollution levels.


Normal IQ distributions of early-treated phenylketonuric children and their unaffected siblings: failure to replicate a trimodal response or negative skew.


Fate of vitamin B 6 in the I-strain mouse.


Control of iron absorption by the gastrointestinal mucosal cell.


Computer-aided patient monitoring: capabilities and planning considerations.


Edmund Andrews--forgotten pioneer of Chicago urology.


Howard Lang Alt 1900-1972.

Howard Lang Alt 1900-1972.


Relations between immunity and malignancy. A higher incidence of malignancy as well as greater susceptibility to infection has been found to be associated with primary immunodeficiencies. An increased incidence of leukemia has been associated with X-linked infantile agammaglobulinemia-an isolated defect of humoral immunities. An increased frequency of a wide variety of malignancies have been found to accompany several different forms of primary immunodeficiency. Secondary immunodeficiencies produced by immunosuppressant therapy to facilitate renal transplantation have also been found to have far too much cancer to be explained by chance assocaition. Many experimental associations between immunity and malignancy have also been encountered, indicating that these two adaptive processes have an essential relationship that must be elucidated.


Comments on Freud and Kronos.

Comments on Freud and Kronos.


Frank Raymond Blood (September 13, 1910--January 31, 1971).


Correlation of prolonged insecticide exposure and the activity of the inhibition of cochlea N 1  potential.


Effects of nerve growth factor antiserum on peripheral unmyelinated nerve fibers.


The otomicroscope and microsurgery 1921-1971.


Isolation of Erysipelothrix rhusiopathiae from soil and manure of swine-raising premises.


In vitro cultivation of Neorickettsia helminthoeca, the causative agent of salmon poisoning disease.


Oxidative phosphorylation in yeast. 8. Osmotic and permeability properties of mitochondria isolated from wild-type yeast and from a respiration-deficient mutant.


Oxidative phosphorylation in yeast. IX. Modification of the mitochondrial adenine nucleotide translocation system in the oxidative phosphorylation-deficient mutant op 1 .


Effects of tropomyosin, troponin and Ca 2+  on the interaction between F-actin and heavy meromyosin.


Biochemical aspects of the visual process. XIX. Formation of isorhodopsin from photolyzed rhodopsin by bacterial action.


A study of the effects of early bone-grafting in complete clefts of the lip and palate--five year study.


Grant of arms.

Grant of arms.


Dacryo-cystography in mid-facial fractures.


A case of carbolic acid gangrene of the thumb.


Intradermal double eyelid operation and its follow-up results.


Closure of rhomboid skin defects: the flaps of Limberg and Dufourmentel.


The naso-labial full thickness graft.

The naso-labial full thickness graft.


The influence of surgical pathology on plastic surgical procedures.


Accuracy of registered causes of neonatal deaths in 1958.


Trial of an oral bacterial antigen against common colds.


Area differences in prevalence of neural tube malformations in South Wales. A study of possible demographic determinants.


A survey of DNA content per cell and per chromosome of prokaryotic and eukaryotic organisms: some evolutionary considerations.


Episomes in evolution.

Episomes in evolution.


Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.


Bernardo Alberto Houssay. His life--his work.


The diabetic syndrome in the tuco-tuco (Ctenomys talarum).


Effects of postnatal feeding on the functional maturation of pancreatic islet B-cells of neonatal rats.


Non-invasive methods of selecting patients for closed heart surgery.


Cytochemical and immunofluorescence investigations on polypeptide hormone localization in the pancreas and gut of the larval lamprey.


Feedback regulation of testicular function in Japanese quail: testosterone implants in the hypothalamus and adenohypophysis.


Presidential address. Pathogenesis of immunologic disease.


Genetic control of the immune response of inbred guinea pigs to 2,4-dinitrophenyl guinea pig albumin. Frequency of antigen-binding lymphocytes and avidity of antibodies secreted by plaque-forming cells.


Alloimmune hemolytic plaque-forming cells: kinetics of IgM and IgG alloantibody releasing cells during a primary and secondary immune response of chickens.


Myasthenia gravis: cross-striational fluorescence of muscle fibers mediated by Fc fragments.


Sensitization of guinea pigs to alpha-chloroacetophenone (CN) and ortho-chlorobenzylidenemalononitrile (CS), tear gas chemicals.


Lymphoma metastatic to the mandible.

Lymphoma metastatic to the mandible.


Chemical carcinogenesis and humoral antibody synthesis.


Reaction mechanisms of nascent C567 (reactive lysis). I. Reaction characteristics for production of EC567 and lysis by C8 and C9.


Genetics of the immune response. I. Differences in the specificity of antibodies to lipopolysaccharides among different strains of mice.


A specific mouse B lymphocyte antigen (MBLA) demonstrated by double immunofluorescence.


Language and speech pathology in cerebral palsied children.


An assessment of the analgesic effects of nitrous oxide on the primary dentition.


Mitogenic factors produced by lymphocyte activation: effect on T- and B-cells.


The miracle workers.

The miracle workers.


Appendix and  M antibody formation. V. Appendix and thymus cell synergism in the direct and indirect plaque-forming cell responses to sheep erythrocytes in the rabbit.


A cytological study of the ovary of Rhodnius prolixus. II. Oocyte differentiation.


Root canal therapy for infected primary molar teeth--preliminary report.


The significance of heart rate for behavior: a critique of Lacey's hypothesis.


Impact loading of amalgam supported by bases of varying compressive strengths.


Preventive oral surgery and orthodontics.


Sarratia marcescens septicemia: report of 2 cases with survival.


Professor William Rimmer Lee. The new professor of occupational health.


Geriatric medicine.

Geriatric medicine.


Recent advances in the management of chronic renal disease.


Ribosomal proteins: variation of the protein composition in Escherichia coli ribosomes as function of growth rate.


In vitro culture of rabbit ova fertilized by epididymal sperms in chemically defined media.


Effect of calcitonin on vitamin D metabolism.


Prevention of cholera-induced intestinal secretion in the cat by aspirin.


Vitamin C requirements and oral contraceptives.


Hyperbaric oxygen: an adjuvant in renal preservation.


High altitude, haematocrit and age.

High altitude, haematocrit and age.


Control of the heart rate by external stimuli.


Telemetry of heart rate in diving seals.


Role for protein phosphorylation in meiosis and in the early cleavage phase of amphibian embryonic development.


Mammary stimulation causes prolactin secretion in non-lactating women.


Cross-reinnervation of dystrophic mouse muscle.


Dextrans and fibrin morphology.

Dextrans and fibrin morphology.


Changes in the fibre content of the British diet.


Brush technic for endometrial cytologic study.


Professor F. J. W. Roughton.

Professor F. J. W. Roughton.


Geoffrey W. Harris, 1913-1971.

Geoffrey W. Harris, 1913-1971.


Whitehead's radical circumferential hemorrhoidectomy modified by sliding skin-flap grafts.


Physiology of the colon and rectum.

Physiology of the colon and rectum.


Immunologic tests for the detection of gastrointestinal cancers.


Botulism in birds and mammals in Great Britain..


A review of some effects on health and performance of variations in the physical form of the diet of the growing pig. II. Fibrous constituents and water level.


Laboratory data analysis system. I. Introduction and overview.


Laboratory data analysis system. 3. Multivariate normality.


Laboratory data analysis system. II. Analytic error limits.


Laboratory data analysis system. IV. Multivariate diagnosis.


Laboratory data analysis system. V. Trend analysis.


Laboratory data analysis system. VI. System summary.


The inter-relationships between renal prostaglandins and blood pressure regulation.


Replication of extrachromosomal elements in a DNA synthesis initiation mutant of Salmonella typhimurium.


Biosynthetic routes to ergosterol in yeast.


A nuclear magnetic resonance study of the binding of substrate analogues to a modified aspartate transcarbamylase.


DNA dependent RNA polymerase catalyzed synthesis of polyribonucleotide chains covalently linked to DNA.


Inhibition of GTP hydrolysis depending on G factor and ribosomes by a factor prepared from the ribosome wash of E. coli Q13.


Utilization of deoxynucleoside triphosphates by DNA-dependent RNA polymerase of E. coli.


In vivo release of antidiuretic hormone by direct application of acetylcholine or carbachol to the rat neurohypophysis.


Purified growth hormone releasing factor increases  45 Ca uptake into pituitary cells.


Effects of plumbous ion on some functions of transfer RNA.


Clinical research ought to assert itself.


Ear flaps.

Ear flaps.


Kr. Kenneth M. Day: a courageous otologist overcomes his infirmity.


Avascular necrosis of the femoral head in the adult. A review of its incidence in a variety of conditions.


Yellow fever fighters--Dr. Joseph Y. Porter, Dr. Isaac Hulse.


Corrosion-related failures in metallic implants: an experimental study.


Problems of the composition and structure of the bone minerals.


The United States Marine Hospital, Key West, 1845-1943.


Reminiscences of Navy Medicine, Key West, 1941-1943.


A doctor and an island.

A doctor and an island.


James M. Jackson, Jr. Miami's first physician.


Mutants of Escherichia coli with temperature-sensitive lesions in membrane phospholipid synthesis: genetic analysis of glycerol-3-phosphate acyltransferase mutants.


Studies on the morphogenesis of yeast mitochondria. II. Composition of Saccharomyces cerevisiae phospholipids during morphogenesis and their effect on restoration of succinoxidase activity of lipid mitochondria.


Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons.


Relief of polarity in DNA-dependent cell-free synthesis of enzymes of the galactose operon of Escherichia coli.


Diagnosis of vaginal mycosis and trichomoniasis. Reliability of cytologic smear, wet smear and culture.


Primary lymphoma of the vagina.

Primary lymphoma of the vagina.


In memoriam. Solomon A. Berson, M.D. 1918-1972.


Stromal theca cell function.

Stromal theca cell function.


The temporal expression of T2r +  bacteriophage genes in vivo and in vitro. The kinetic order of synthesis of deoxycytidylate deaminase (EC 3.5.4.12), deoxycytidylate hydroxymethylase (EC 2.1.2.b), dihydrofolate reductase (EC 1.5.1.3), 5-hydroxymethyldeoxycytidylate kinase (EC 2.7.4.4), and thymidylate synthetase (EC 2.1.1.b) after infection of Escherichia coli with T2r(+) bacteriophage was found not to correlate with their order of synthesis in an in vitro protein-synthesizing preparation. The in vivo and in vitro synthesis of enzyme-specific messenger RNA measured in the protein-synthesizing preparation preceded each enzyme by about 1 min. Through the use of sheared DNA, it was shown that the thymidylate synthetase gene was most susceptible to a loss in template activity, which suggests that this gene is further removed from its promoter than the other genes are from theirs. With a DNA segment of 2.5 x 10(5) daltons, the synthesis of dihydrofolate reductase alone was obtained, but at a much reduced rate. Translation of the RNA from phage-infected cells treated with chloramphenicol yielded amounts of dihydrofolate reductase and deoxycytidylate hydroxymethylase activities similar to those obtained with RNA from untreated infected cells. These results suggest that the chloramphenicol RNA, which consists primarily of immediate-early RNA, may contain most, if not all, of the information required for the synthesis of phage dihydrofolate reductase and deoxycytidylate hydroxymethylase.


The absorption of folic acid in man: recent progress.


Transcription in yeast: separation and properties of multiple FNA polymerases. Four peaks of DNA-directed RNA polymerase activity are resolved by salt gradient elution of a sonicated yeast cell extract on DEAE-Sephadex. The enzymes, which are named IA, IB, II, and III in order of elution, all appear to come from cell nuclei. Only enzyme II is sensitive to alpha-amanitin. All enzymes are more active with Mn(++) than with Mg(++) as divalent ion. Enzymes IB and II have salt optima in the range 0.05-0.10 M (NH(4))(2)SO(4), whereas enzyme III is maximally active at 0.20-0.25 M (NH(4))(2)SO(4). With optimal salt concentration and saturating DNA, the template preference ratio, activity on native calfthymus DNA divided by activity on denatured calf-thymus DNA, is 2.2 for IB, 0.4 for II, and 3.5 for III. None of the yeast polymerases was inhibited by rifamycin SV. Rifamycin AF/013 effectively inhibited polymerases IB, II, and III.


2 -Microglobulin--a free immunoglobulin domain. Analysis of the primary structure of beta(2)-microglobulin indicates that this human protein is homologous in sequence to the constant portion of immunoglobulin light chains (C(L)), and to the homology regions (C(H)1, C(H)2, and C(H)3) of the constant portion of gamma1 (heavy) chains of immunoglobulin G. Homology with the C(H)3 region is particularly striking. No convincing homology could be demonstrated by similar comparisons with the variable regions of immunoglobulin light and heavy chains. beta(2)-Microglobulin contains an intrachain disulfide loop of 57 amino-acid residues that is similar in size to disulfide loops found in the constant regions of immunoglobulin G. These findings suggest that beta(2)-microglobulin is a free immunoglobulin domain, possibly serving an effector function similar to that of the C(H)3 domain of gamma1 chains of immunoglobulin G.


Polypeptide chain initiation in eukaryotes: functional identity of supernatant factor from various sources. Eukaryotic cells contain polypeptide chain initiation factors that, like the prokaryotic initiation factor IF-2, promote the AUG-dependent binding of fMet-tRNA(f) to the small ribosomal subunit. The bound amino-acyl-tRNA is directly convertible to fMet-puromycin upon addition of 60S subunit. The reaction is sensitive to initiation inhibitors such as aurintricarboxylic acid and edeine but, unlike its prokaryotic counterpart, it does not require GTP. Factors that catalyze the binding and fMet-puromycin reactions with ribosomal subunits from Artemia salina embryos are present in postribosomal supernatants of Artemia, mouse fibroblasts (L cells), and rat liver, as well as in salt washes of rabbit reticulocyte ribosomes. However, whereas all three supernatant factors, like Escherichia coli IF-2, are sensitive to SH-binding reagents, the reticulocyte factor is not. The rat liver and Artemia factors function indiscriminately with Artemia or rat liver ribosomes, but the Artemia factor and E. coli initiation factor IF-2 are not interchangeable.


Natural-abundance carbon-13 Fourier-transform nuclear magnetic resonance spectra and spin lattice relaxation times of unfractionated yeast transfer-FNA. High-resolution Fourier-transform nuclear magnetic resonance at 15.18 MHz was used to observe the proton-decoupled natural-abundance (13)C spectra of aqueous unfractionated tRNA from baker's yeast in the presence of Mg(+2) (8 ions per tRNA molecule), as a function of temperature in the range of 27-82 degrees C. The spectrum of thermally denatured tRNA at 82 degrees C showed numerous sharp resonances, which were assigned to specific types of carbon atoms by comparison with the (13)C spectra of mononucleotides. Only the resonance of carbon 4' of the ribose rings was appreciably shifted (by about 1.5 ppm upfield) with its average position in the mononucleotides. This effect was also seen in the spectrum of poly(A). In the spectrum of folded tRNA (52 degrees C), carbon 4' was further shifted upfield by about 1.5 ppm, and carbons 2' and 3', which yielded a single resonance at 82 degrees C, now showed two partly resolved peaks. The variation of linewidths with temperature (200 mg/ml of tRNA) was gradual in the range 27-82 degrees C, and did not reflect the expected unfolding behavior of tRNA. Moreover, dilution to 80 mg/ml at 27 degrees C had the same effect as an increase in temperature to about 45 degrees C. The line-width changes below 60 degrees were ascribed to tRNA aggregation. In contrast to the behavior of the linewidths, the (13)C spin-lattice relaxation times (T(1)) of individual ribose carbon atoms, measured by means of partially relaxed Fourier-transform spectra were practically independent of temperature up to about 60 degrees C, and increased rapidly at higher temperatures. The T(1) values indicated that the backbone of thermally denatured tRNA is undergoing rapid segmental motion, with an effective correlation time of (2.6 +/- 0.5) x 10(-10) sec. The T(1) values of folded tRNA yielded no evidence of segmental motion. The correlation time for overall rotational reorientation is about (3 +/- 1) x 10(-8) sec in the range 35-54 degrees C. Within experimental error, the T(1) values of methine carbons of the bases were equal to those of the methine carbons on the backbone at all temperatures. Only an upper limit to the rate of internal rotation of the bases could be established.


In vitro synthesis of enzymes of the tryptophan operon of Escherichia coli. Two active enzymes of the tryptophan operon of E. coli, anthranilate synthetase (product of trp E and trp D) and tryptophan synthetase (EC 4.2.1.20) (product of trp B and trp A), have been synthesized in a DNA-dependent preparation for protein synthesis. Anthranilate synthetase and the two components of tryptophan synthetase (tryptophan synthetase A and B) are made in vitro in equimolar amounts, suggesting that regulation of the translation is similar in vivo and in vitro. Kinetics of the synthesis of the two enzymes suggest that transcription and translation proceed in vitro in a correct temporal sequence.


Initiation factor IF-3-dependent binding of Escherichia coli ribosomes and N-formylmethionine transfer-RNA to rabbit globin messenger. An initiation complex has been formed in high yields from E. coli ribosomes, 9S messenger RNA for rabbit hemoglobin, and N-formylmethionine-tRNA. Initiation factor IF-3 is required for the binding and puromycin is required for the release of fMet. Valyl-tRNA fails to bind to the second codon, whereas a mixture of 15 aminoacyl-tRNAs promotes incorporation. Together with quantitative data, the findings suggest that IF-3 directs the ribosomes to an AUG codon on one of the two globin messengers, at a site that is different from the normal starting point for globin synthesis.


RNA-linked nascent DNA fragments in Escherichia coli. Nucleic acid that is extracted from E. coli labeled by a brief pulse of [(3)H]dT and depatured by treatment with heat, formamide, or formaldehyde bands in a region with a density higher than that of single-stranded E. coli DNA in a Cs(2)SO(4) equilibrium density gradient. If treated with alkali or RNase, it then exhibits the density of single-stranded DNA. These results suggest the presence of a short strand of RNA covalently linked to the nascent DNA. Evidence for the presence of covalently linked RNA-DNA molecules is also obtained by pulse labeling with [(3)H]U. Analyses of nascent nucleic acids from cells pulse labeled for various times, and of the molecules with different sizes, support the hypothesis that the short DNA fragments are formed by extension of even shorter RNA chains, which are synthesized on the parental DNA strands and are removed before ligation of the DNA fragments. The synthesis of the RNA segment of the RNA-DNA molecule is much less sensitive to rifampicin than is the synthesis of bulk RNA.


Characterization by electron microscopy of fused F-prime factors in Escherichia coli. During previous attempts to find mutants in which incompatibility between two F-prime (F') factors of E. coli is abolished, we found that two F' factors harbored in the same cell occasionally recombined to form a single genetic unit. Thus, a fused F'trp(+)arg(+) factor was obtained from a mating of a strain carrying recA F'trp(+) with a strain carrying recA F'arg(+). In the present paper physical fusion of the two F' factors, inferred from genetic studies, is confirmed by electron microscopy. F DNA was extracted, after detergent lysis, from four fused F' strains: the parental F'trp(+) and F'arg(+) strains and three F(+) strains. This supercoiled DNA was separated on ethidium bromide-cesium chloride gradients and converted to the open circular from before electron microscopy. The contour lengths in mum of the various DNA preparations were: F'trp(+), 59.4; F'arg(+), 33.2; the four F'trp(+)arg(+) factors, 38.5, 39.6, 63.2, and 73.5: the three F factors, 31.1, 31.1, and 31.0. Thus, different fused F' factors formed from the same parental F' factors vary in length, but are shorter than the sum of the parental F' factors.


Deletion mutants of bacteriophage phiX174. Mutants of bacteriophage varphiX174 have been isolated that are less dense than wild-type varphiX particles in CsCl. When mutant viral (+) strand DNA and wild-type complementary (-) strand DNA are hybridized, the resulting duplex molecules have single-stranded loops characteristic of wild-type-deletion heteroduplexes. The mutant bacteriophages fail to complement varphiX amber mutants in cistron E. We conclude that the mutant viruses have deleted approximately 7% of the varphiX genome in the region of cistron E.


Phenylalanyl-tRNA synthetase and isoleucyl-tRNA Phe : a possible verification mechanism for aminoacyl-tRNA. The synthesis of isoleucyl-tRNA(Phe) (Escherichia coli) proceeds at an appreciable rate under normal in vitro conditions in the presence of isoleucyl-tRNA synthetase (EC 6.1.1.5) from E. coli. The misacylated product is shown here to be hydrolyzed by highly purified phenylalanyl-tRNA synthetase from E. coli, with release of isoleucine and active tRNA(Phe). Thus, phenylalanyl-tRNA synthetase possesses a previously unrecognized activity, which deacylates a mistakenly acylated tRNA(Phe); the enzyme is inactive toward correctly matched aminoacyl tRNAs. Such a mechanism could serve to verify aminoacyl-tRNAs, deacylating those that are misacylated. Thus, a common generalization needs to be modified: an amino acid is not necessarily committed to a given (incorrect) anticodon when it is incorporated into aminoacyl-tRNA. It may be possible to correct it thereafter.


An in vitro system for chemotherapy studies on amastigote forms of T. cruzi and Leishmania.


A comparative evaluation of the treatment of Schitosoma mansoni with niridazole and potassium antimony tartrate.


Fluorescent antibody studies in cats infected with Brugia pahangi.


Effects of x-irradiation and cortisone treatment of albino rats on infections with Brucei-complex trypanosomes.


An outbreak of cercarial dermatitis in Britain.


Epidemiological study of infections in the mosquito: selective trapping of unfed malaria-filariasis vectors seeking a blood meal in bedrooms.


Mycobacterium leprae: club and other forms of unknown viability.


Renal involvement in leprosy.

Renal involvement in leprosy.


Suppression of the immune response to heterologous erythrocytes in mice infected with Plasmodium berghei berghei.


? sp. trypanosomes in the semi-digested blood meal of a female Culex pipiens collected in an outhouse in late August 1971. Comparisons between oöcysts of P. vivax and P. berghei as seen in sections of Anopheles stephensi.


The role of excretion of acid phosphatase in Trypanosoma brucei and T. cruzi.


Penetration of bloodstream and metacyclic forms of Trypanosoma cruzi through mucous membranes. Ease of penetration through the nasal mucosa.


Treating acute fingertip injuries.

Treating acute fingertip injuries.


Serologic examinations in rheumatology.

Serologic examinations in rheumatology.


Topical lomustine in the treatment of psoriasis.


Cicatricial pemphigoid. Immunofluorescent studies.


Ultraviolet lamps for room air disinfection. Effect of sampling location and particle size of bacterial aerosol.


Purpura factitia. An analysis of criteria for its differentiation from auto-erythrocyte sensitization purpura.


Antibiotic-resistant coliforms in fresh and salt water.


Prolonged lymphocytopenia in the rat. the immunological consequences of lymphocyte depletion following injection of  185 W tungsten trioxide into the spleen of lymph nodes.


Reversible alkylation of a methionyl residue near the active site of  -galactosidase.


Investigations on the alkaline phosphatase catalyzed hydrolysis of phosphoramidates. Substituent effects and transphosphorylation.


Circular dichroism study of nine species of transfer ribonucleic acid.


Inhibition of cell-free protein synthesis by poly(9-vinyladenine), poly(1-vinyluracil), and the corresponding vinyl copolymer.


Effect of polypeptide chain length on dissociation of ribosomal complexes.


Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension.


Cortisol and aldosterone excretion and plasma cortisol concentrations in normal and obese female subjects.


Special article: functional implications of human portal and bile ductular ultrastructure.


The liver and blood coagulation: physiology and pathology.


Peritoneal mesothelioma.

Peritoneal mesothelioma.


Specialization in medicine.

Specialization in medicine.


Bacteriological analysis of air. Construction of a large-volume manual pump.


The incidence of anemia in Latin America.


Intestinal absorption of folates.

Intestinal absorption of folates.


The pancreas and vitamin B 12  absorption.


Vitamin B 6  deficiency and brain lipids in the suckling rat.


Excretion of methylmalonic acid by vitamin B 12  deficient rats kept under germfree or conventional conditions.


The control of glucagon secretion.

The control of glucagon secretion.


The low-carbohydrate diet in the treatment of chronic dyspepsia.


Nutrition and enteric diseases in calves.


The use of antibiotics as feed additives for farm animals.


Clonidine induced intrahypothalamic stimulation of eating in rats.


Treatment of osteoporosis with phosphate.


Treatment of Paget's disease with fluoride.


Treatment of Paget's disease with a diphosphonate (sodium etidronate).


Treatment of rickets and osteomalacia.

Treatment of rickets and osteomalacia.


Growth of the epiphyseal plate in circumference.


The early years of the Southern Thoracic Surgical Association.


Effect of nigral and raphé lesions on the catechol-O-methyl transferase and monoamine oxidase activities in the rat striatum.


Medicine in St. Louis a century ago.

Medicine in St. Louis a century ago.


Pimozide: a comparative study in the treatment of chronic schizophrenic patients.


The clinical evaluation of anti-arthritic drugs.


Clinical trial with cephapirin.

Clinical trial with cephapirin.


Comparative treatment study of migraine headache.


Effects of N-methyl peptide bonds on peptide utilization by Escherichia coli.


Amber mutants of the  -ketoglutarate dehydrogenase gene of Escherichia coli K12.


Variations in the peptidase activities of Escherichia coli in response to environmental changes.


The host specificities of the Z20 and CF2004-6 strains of an Escherichia coli O4 serotype.


DNA synthesis in gamma-irradiated recombination deficient strains of Escherichia coli.


R124, an fi R factor of a new compatibility class.


Segmental sagittal splitting of the mandible in the surgical treatment of carcinoma of the floor of the mouth.


Hemodialysis in small children.

Hemodialysis in small children.


Pollution of the water.

Pollution of the water.


Some twentieth century poison panics.

Some twentieth century poison panics.


Secretory immunoglobulins.

Secretory immunoglobulins.


Advantages of lay advice.

Advantages of lay advice.


Editorial: Dr. Kurt Hermann Thoma.

Editorial: Dr. Kurt Hermann Thoma.


In memoriam: Kurt Hermann Thoma, D.M.D., Editor Emeritus.


Studies on masticatory functions in patients with surgical mandibular reconstruction.


Primary reticulum-cell sarcoma of the alveolar mucosa.


Inflammation and infection of pulp and periapical tissues.


Dental plaque reduction with an antibacterial mouth rinse. I.


Characterization of the hormonal responses to luteinizing hormone-releasing hormone (LH-RH) in prepubertal and adult subjects.


Diagnosis and treatment of the Lesch-Nyhan syndrome.


Gastrointestinal hormones and insulin secretion.


Use of blood volume estimations in a general medical unit.


Ano-rectal motility in sick children.

Ano-rectal motility in sick children.


Primary amoebic meningo-encephalitis. An appraisal of present knowledge.


Sulphadoxine and pyrimethamine as treatment for acute Plasmodium falciparum malaria.


Clinical trial with L-tetramisole in roundworm and hookworm infections.


The response of triatomine bugs to betalights.


Human "healthy carriers" of Trypanosoma (brucei type) discovered by immunofluorescence test in the Republique Democratique du Congo.


Preliminary electron microscope observations on the amastigote forms of Trypanosoma cruzi and Leishmania donovani.


Adoptive immunity in experimental trypanosomiasis.


The specificity of the fluorescent antibody test for trypanosomal infections in rodents.


Some aspects of aminotransferases of trypanosomes.


Further experiments with the nucleoside trypanocide, cordycepin.


Occlusion of all four extracranial vessels with minimal clinical symptomatology. Case report.


The pathogenicity of Rift Valley fever virus for the baboon.


Pyrimethamine resistance in The Gambia: a failure to prevent experimental infection with Plasmodium falciparum in a "non-immune".


Dissent on the alleged finding of chloroquine resistance in East Africa.


Adoptive immunotherapy in malignant disease.


Fifty years of orthopaedic care for crippled children.


Mental hygiene clinics in Virginia.

Mental hygiene clinics in Virginia.


Medicare--B.

Medicare--B.


A study of the properties of sorbent, the reagent employed in the fluorescent treponemal antibody-absorption test.


Salmonellosis associated with whale meat in an Eskimo community. Serologic and bacteriologic methods as adjuncts to an epidemiologic investigation.


Clinical evaluation of a new benzodiazepine derivative, Chlorazepate.


Intestinal absorption and gastro-intestinal digestion of protein in the young rat during the normal and cortisone-induced post-closure period.


Transport and transport-associated phosphorylation of galactose in Saccharomyces cerevisiae.


Organization of proteins in the native and reformed outer membrane of Escherichia coli.


A case of spondylitis tuberculosa in the Danish Neolithic Age.


The DNA-RNA hybridisation of ( 3 H) methylated mouse-globin mRNA in conditions of RNA excess.


DNA methylases of Escherichia coli K12. Evidence for changes in their state of association following purification.


The dual genetic control of ornithine carbamolytransferase in Escherichia coli. A case of bacterial hybrid enzymes.


The inability of T-even phages to produce heat-stable density mutants and its bearing on chromosome maturation.


Tumour production in immunosuppressed rats with cells transformed in vitro by adenovirus type 2.


Gene activation during early development of mammals.


Cytochalasin B. IV. Inhibition and stimulation of chemotaxis of rabbit and human polymorphonuclear leukocytes.


Transfer of experimental allergic orchitis with peritoneal exudate cells.


Binding in vivo of enhancing antibodies to skin allografts and specific allogeneic tissues.


Cell interactions in antibody formation in vitro. I. Role of the third cell in the in vitro response of spleen cells to erythrocyte antigens.


Passive immunization against the local Shwartzman reaction.


The secondary response to high and low dose priming in mice.


Endocytosis by lymphocytes of complexes of anti-Ig with membrane-bound Ig.


Frozen-fractured viruses; a study of virus structure using freeze-etching.


The effect of radio-frequency sputter ion etching and ion-beam etching on biological material: a scanning electron microscope study.


A new single-drop technique for the observation of dynamic blood coagulation.


Some observations on the filaments of frozen-etched striated muscle.


Usefulness of the instantaneous fixation procedure of Párducz for the demonstration of cell surface specializations in scanning electron microscopy.


Utilization of a prepaid plan of commercial dental insurance.


Fluoride intoxication in fish: a review.


Surgical treatment of obstructive disease of the brachiocephalic vessels.


Drugs and breast milk.

Drugs and breast milk.


Pharmacology of anticonvulsants.

Pharmacology of anticonvulsants.


Pharmacogenetics.

Pharmacogenetics.


Clinical pharmacology of digoxin.

Clinical pharmacology of digoxin.


Fetal pharmacology.

Fetal pharmacology.


Medicare liaison committee.

Medicare liaison committee.


A review of cryotherapy.

A review of cryotherapy.


Infection associated with immunosuppressive therapy.


Infection associated with modern surgical procedures.


Intravascular coagulation.

Intravascular coagulation.


Subacute sclerosing panencephalitis.

Subacute sclerosing panencephalitis.


The comparative value of amantadine and levodopa.


Spirochetal organisms from pigs. I. Isolation, cultivation and maintenance.


Neuroanatomical correlates of morphine dependence. Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.


Intravenous injection in man of   9 -tetrahydrocannabinol and 11-OH-  9 -tetrahydrocannabinol. A microsuspension of Delta(9)-tetrahydrocannabinol and of its metabolic derivative 11-OH-Delta(9)-tetrahydrocannabinol has been prepared with 25 percent human serum albumin as the vehicle. Intravenous infusion of this preparation to humans indicates that both tetrahydrocannabinols are equally potent in producing the typical marihuana-like pschological and physiological effects.


The effect of host liver damage, portacaval shunt, and various immunosuppressive regimes on canine auxiliary liver transplantation.


The effect of prior blood transfusions on hemopoietic grafts from histoincompatible canine littermates.


Transplantation reactions of two species of Osteichthyes (Teleostei) from South Pacific coral reefs.


The effect of combined immunosuppressive agents and cell-free antigen on xenograft survival.


Oncogenic effect of repeated inoculation of mice with sheep erythrocytes.


Infectious diseases: annual review of significant publications.


Encircling suture of the cervix in placenta praevia. Ten years experience.


Inactivation of oxytocin by human myometrial preparations. I. Preliminary evidences for the presence of a thiol-oxido-reductase activity and an amino-peptidase activity in crude extracts.


Total protein content in amniotic fluid from normal pregnancies and from pregnancies complicated by rh-isoimmunization.


The pressure-flow relationship in renal cortical and medullary circulation.


Paul Hamilton Wood.

Paul Hamilton Wood.


Obituaries: Paul Wood's death in 1962 noted by the leading British medical journals.


Paul Wood's textbook.

Paul Wood's textbook.


Paul Wood revisited. Selected articles and commentary from Paul Wood's bibliography.


Remembering Paul Wood.

Remembering Paul Wood.


Presentation of the gold headed cane to Esmond R. Long.


Creativity in the person who will never produce anything original and useful: the concept of creativity as a normally distributed trait.


Glomerulonephritis associated with sarcoidosis. Clinical findings and structural alterations in the kidneys of 6 patients with sarcoidosis and an associated glomerulonephritis are described. Five of the 6 patients manifested the nephrotic syndrome during some phase of their illness. Additional clinical evidence of renal disease included persistent microscopic hematuria (5 patients), hypertension (4 patients) and progressive renal failure (3 patients). Glomerular pathology varied and included proliferative glomerulonephritis (3 patients), membranous glomerulonephritis (1 patient), and chronic glomerulonephritis (2 patients). In 2 patients sequential examination of the kidney was possible, with renal biopsies preceding autopsy examination by 3 and 6 years, respectively. Glomerular pathology had progressed in severity in each case. Immunofluorescent studies in 2 patients revealed patterns of glomerular antibody localization consistent with immune complex disease. Electron microscopic studies of 1 revealed membranous changes characterized by electron-dense subepithelial and intramembranous deposits. Totally unexpected were virus-like intraendothelial structures in the glomeruli identical to those previously reported in systemic lupus erythematosus. Since current evidence suggests that the pathogenesis of both membranous and proliferative types of glomerulonephritis is immunologic, it should not be surprising that sarcoidosis, a disease which quite possibly results from an immune response to a disseminated antigen(s), should occasionally include glomerulonephritis as a part of its histologic expression.


Upper lid reconstruction.

Upper lid reconstruction.


Mitotics in cataract surgery.

Mitotics in cataract surgery.


Hybridization studies with yeast mitochondrial RNAs.


Deficiency of the DNA of Micrococcus radiodurans in methyladenine and methylcytosine.


Role of the endoplasmic reticulum membrane in the sulfhydryl requirement for protein synthesis.


An investigation of bladder-urethral function by pressure-flow studies.


Arterial pressure waveform recording: a clinical system.


Zoological and wild-life reviews.

Zoological and wild-life reviews.


3. Attempts at emergency surgical treatment.


Constrictive pericarditis due to infection with Nocardia asteroides.


Analysis of problems related to cuffs on intratracheal tubes.


Chicago Dental Society roster of associate members--1972.


Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten. II. Clinical studies.


Significance of amount and avidity of E. coli O antibodies for manifestation of their serological and protective properties. A preliminary study.


Nucleic acid and protein synthesis in reconstituted lyophilized Escherichia coli exposed to air.


Electronmicroscopie observations on the degradation of cellulose fibres by Cellvibrio fulvus and Sporocytophaga myxococcoides.


Mathematical-ecological aspects of the examination for enterobacteriaceae of foods processed for safety.


Some properties of the nonsporing anaerobes from poultry caeca.


Separation of colicins by polyacrylamide gel electrophoresis.


Bacteriological studies on bulk milk collection: pipeline milking plants and bulk milk tanks as sources of bacterial contamination of milk--a review.


Viability of clostridial spores and the requirements of damaged organisms. 3. The effect of delay in plating after exposure to the bactericidal influence.


The germicidal properties of ozone-olefin mixtures.


The relationship between the intestinal microflora and the effects of diets containing raw navy beans (Phaseolus vulgaris) on the growth of Japanese quail (Coturnix coturnix japonica).


Influence of some preservatives on the quality of prepacked cod fillets in relation to the oxygen permeability of the film.


A pectate gel medium for the isolation and diagnosis of pectinolytic bacteria.


Diffusate media for cultivation of oral anaerobic bacteria.


Dr. Fujio Miura on direct bonding of plastic brackets.


Roster of members. Kansas State Dental Association.


Clinical assessment of vertical dimension.


Errors caused by dimensional change in mounting material.


Considerations in design of removable prosthetic devices with no posterior abutments.


A manipulative appliance.

A manipulative appliance.


A comfortable silicone bulb obturator with or without dentures.


Experiences of a neophyte athlete.

Experiences of a neophyte athlete.


The hospital care of East African children. The child is admitted: obstacles and opportunities. Cross-infection--risks and remedies.


The olympic games.

The olympic games.


Injuries and complications of the lymphatic system following renal transplantation.


Differences between behavior reinforced by electrical stimulation of the brain and conventionally reinforced behavior: as associative analysis.


On the identification of repeatedly presented, brief visual stimuli.


Egocentrism and social interaction across the life span.


Glutaraldehyde fixation of human blood platelets.


14 C-warfarin excretion in the rat.

14 C-warfarin excretion in the rat.


Tongue-thrust therapy and anterior dental open-bite. A review of new facial growth data.


A universal direct bonding system for both metal and plastic brackets.


Social and clinical issues in geriatric psychiatry.


Working session report: natural products.


Second Joint Working Conference: National Cancer Institute Chemotherapy Program. Working session report: clinical trials.


Determinants of pulmonary vascular volume: recruitment versus distensibility.


Mechanisms of heavy metal toxicities.

Mechanisms of heavy metal toxicities.


Selenium poisoning in domestic animals and its relationship to man.


British anti-lewisite (BAL), the classic heavy metal antidote.


Organophosphorus compounds; the past and the future.


Oxalate toxicosis.

Oxalate toxicosis.


Trypanosoma lewisi: immune spleen cell transfer in rats.


Immunological aspects of bovine trypanosomiasis. I. Immune response of cattle to infection with Trypanosoma congolense and the antigenic variation of the infecting organisms.


Leslie A. Stauber: a personal appreciation.


Permanently installed digestive cannulae.


New techniques for intensive research with dairy cattle--mineral research.


Effect of tyramine in migraine: a double-blind study. The incidence of headache and changes in the EEG after tyramine were studied in 25 migrainous patients in a double-blind placebo-controlled investigation. There were three groups of patients: the first had migraine alone, the second had migraine and epilepsy, and the third had migraine which was precipitated by food substances containing tyramine. Psychological tests showed that all the patients were more neurotic, more introverted, and more obsessional than normal subjects. Headache occurred in 12 of 50 patient sessions and 10 of these occurred in the group with dietary precipitated migraine. In this group, however, headache followed tyramine alone in only two patients. The remaining eight headaches occurred in two patients after placebo alone, and in three after both test capsules. The EEG was activated after tyramine, but not after placebo, in 11 of the 15 patients with migraine and epilepsy, and dietary precipitated migraine. This effect was observed, however, in only two of the 10 patients with classical migraine alone. There was no relation between the occurrence of headache and EEG activation. Although there was no significant relationship between tyramine ingestion and the occurrence of headache, the EEG changes observed during the study support the hypothesis that tyramine has an action on the central nervous system in some migrainous subjects.


A trial of opipramol in the treatment of migraine. A double blind trial of opipramol (Insidon) compared with placebo for a group of matched patients suffering from migraine has been carried out. The total number of the migraine attacks in a group of 14 patients on opipramol (as compared with the same patients during a pretreatment period of six weeks) showed a 33% reduction in the number of attacks experienced during the first six weeks. During a further consecutive six weeks after this on treatment, attacks were further reduced to 49% as compared with the pretreatment period. In the placebo group there was a 20% increase in the number of migraine attacks in the first six week treatment period as compared with the base line six weeks on no drugs. In the second consecutive six weeks migraine attacks were 2% more frequent than in the pretreatment period. These figures indicate that opipramol is a drug with considerable promise and effectiveness in the control of migraine attacks.


Hemagglutinin and bactericidin response in children with urinary or enteric infections.


Residencies and fellowships in pediatric subspecialties and general academic pediatric training, listed by categories.


Studies on the substrate specificity of the T 4  excision repair endonuclease.


Genetic and physiological analysis of UV-sensitive mutants of Saccharomyces cerevisiae.


Mutagenic effects induced in Saccharomyces cerevisiae by breakdown products of I-naphthylamine and 2-naphthylamine formed in an enzyme-free hydroxylation system.


Newer concepts in chemotherapy of cancer.


Contributions of surgeons to clinical cancer chemotherapy.


Growth inhibitors rapidly inactivated by the host as potential antineoplastic agents in intra-arterial infusion chemotherapy.


Chemotherapy in solid tumors of childhood.


Histocompatibility and the success of intrafamilial renal transplantation.


The significance of antivascular endothelium antibody in renal transplantation.


Prevention of postoperative pulmonary complications.


A labial flap for reconstruction of the anterior oral cavity.


Colonic decompression and lavage in anterior resection of the rectosigmoid.


Comparative susceptibility of Bos indicus and Bos taurus to contagious bovine pleuropneumonia, and the efficacy of the T1 broth culture vaccine.


Commissioner's page.

Commissioner's page.


Hypothalamic control of anterior pituitary function.


Starvation and renal function.

Starvation and renal function.


Introduction of J. C. Snyder as Charles Franklin Craig lecturer for 1971.


A model in vitro system to test the susceptibility of human malarial parasites to antimalarial drugs.


The death rate of Mycobacterium leprae during treatment of lepromatous leprosy with acedapsone (DADDS).


Rapid bactericidal effect of rifampin on Mycobacterium leprae.


The diposition of the antileprotic drug dapsone (DDS) in Philippine subjects.


The effects of various tidal volumes on gas exchange in pulmonary edema.


Topical ampicillin against wound infection after colorectal surgery.


Management of the suspicious Pap smear.

Management of the suspicious Pap smear.


Critical issues in gastroduodenal hemorrhage. The role of vagotomy and pyloroplasty.


A possible role for the Veterans Administration in improvement of health care & medical education.


Early medical conditions in Arizona.

Early medical conditions in Arizona.


Self-stimulation in the frontal cortex of Rattus norvegicus.


Platelets in host resistance: in vitro interaction of platelets, bacteria and polymorphonuclear leukocytes.


Reactions of unmyelinated nerve fibers to injury. An ultrastructural study.


A stereotaxic method for the push-pull perfusion of discrete regions of brain tissue of the unanesthetized rabbit.


The Arthur M. Olsen Festschrift. The scientist and his institution.


Fundoplication for gastroesophageal reflux. A comparison of preoperative and early postoperative manometric findings.


A. M. Olsen Festschrift.

A. M. Olsen Festschrift.


Comparison of left ventricular and pulmonary arterial injection sites in determination of cardiac output by indicator dilution technique.


The pulmonary edema of heroin toxicity--an example of the stiff lung syndrome.


Some observations on rapid expansion followed by bone grafting in cleft lip and palate.


Replication and lysogeny with phage P22 in Salmonella typhimurium.


Applications of bound biopolymers in enzymology and immunology.


Effect of ionic strength, pH, amines and divalent cations on the lytic activity of T4 lysozyme.


Long-lasting damage to the internal male genital organs and their adrenergic innervation in rats following chronic treatment with the antihypertensive drug guanethidine.


Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility. 13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens.  3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg.  10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion.  10 patients were given LH-RH by injection of 50 mch/day for 10 days.  Coitus was indicated every other day from Day 8 of therapy.  Presumptive ovulation was determined on each mode of therapy.  2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception.  4 of the 10 injection patients had presumptive ovulation signs and 2 conceived.  The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus.  The results confirm the therapeutic role of LH-RH in certain cases of sterility.


Gastric operations and glucose homeostasis.


Directory.

Directory.


Intestinal microflora of immunoglobulin-deficient and normal human subjects.


Elisabeth Goldschmidt 1912-1970.

Elisabeth Goldschmidt 1912-1970.


Ken-Ichi Kojima September 17, 1930-November 14, 1971.


Clarence Cook Little October 6,1888-December 22, 1971.


Electron microscopic demonstration of phagocytosis of Candida albicans by human eosinophilic leukocytes.


Irwin Mark Freedberg.

Irwin Mark Freedberg.


Properties of the isolated gene 5 protein of bacteriophage fd.


The specific cross-linking of two proteins from the Escherichia coli 30 s ribosomal subunit.


Maturation and recombination of bacteriophage lambda DNA molecules in the absence of DNA duplication.


Escape synthesis of the biotin operon in induced lambda b-2 lysogens.


A role for recombination in the production of "free-loader" lambda bacteriophage particles.


Physiological effects of environmental stimuli.


Effects of ouabain on impaired left ventricular function in acute myocardial infarction.


Massachusetts nursing homes reconsidered.


Kidney transplant in seven-year-old twins.


From four to one--a successful merger.

From four to one--a successful merger.


Official directory.

Official directory.


The Pharmacopoeia Reformata of London (1744) and its anonymous author.


Some Ohio physicians who contributed to natural history.


Ohio physicians: landmarks.

Ohio physicians: landmarks.


American medical historiography in the 19th Century.


Infleunce of linear energy transfer on the radioresistance of budding haploid yeast cells.


The LD 50  and the survival of bone-marrow colony-forming cells in mice: effect of rate of exposure to ionizing radiation.


Respiratory fluctuations of oxygen tension in central venous blood of anesthetized dogs.


Bovine erythrocyte membrane composition: association with the FV and other glycoprotein systems.


Definition and taxonomy of Anaplasma species with emphasis on morphologic and immunologic features.


A phylogeny of life-cycle patterns of the Digenea.


Intramolluscan inter-trematode antagonism: a review of factors influencing the host-parasite system and its possible role in biological control.


Taeniasis and cysticercosis (Taenia saginata).


"Stitch" granuloma: a consideration in the differential diagnosis of the intramural gastric tumor. Case report.


Extrinsic allergic pneumonias.

Extrinsic allergic pneumonias.


Reduction of toxicity of corticosteroid therapy after renal transplantation.


Glomerular abnormalities in nonsystemic diseases. Relationship between findings by light microscopy and immunofluorescence in 433 renal biopsy specimens.


A new therapeutic approach to Candida infections. A preliminary report.


Nonhypercalcemic sarcoid nephropathy.

Nonhypercalcemic sarcoid nephropathy.


Central nervous system disease associated with Mycoplasma pneumoniae infection.


Clinical experiences with meclocycline in dermatology.


Controlled clinical comparison between two hypnotic combinations and a placebo.


The clinical use of piracetam, a new nootropic drug. The treatment of symptoms of senile involution.


Dangers of pill-taking habit.

Dangers of pill-taking habit.


Michael Somogyi 1883-1971.

Michael Somogyi 1883-1971.


A three-cell mosaic culture: in vitro immune response by a combination of pure B- and T-cells with peritoneal macrophages.


DNA replication as a prerequisite for the induction of primary antibody response.


Selective induction of DNA synthesis in T and B lymphocytes.


Differential susceptibility of mouse lymphocytes to an immunosuppressant from group A streptococci.


Lymphopenia produced by polyethylene-32P strips applied to the rabbit appendix.


Lipopolysaccharides can convert heterologous red cells into thymus-independent antigens.


Failure of repeated or prolonged immunization to stimulate the production of antibody of more than one specificity by individual spleen ceells.


Interferon and its inducers: antiviral and other effects.


Primary amoebic meningoencephalitis.

Primary amoebic meningoencephalitis.


Inhibition of the catabolism of deoxyribonucleosides in Escherichia coli after infection by T 4  phage.


Purification and characterization of 50-S ribosomal proteins of Escherichia coli.


Purification and properties of tryptophan-synthase-inactivating enzymes from yeast.


Some Swiss-British medical relationships in the nineteenth century.


The history of medical relations between Switzerland and the USA.


Preprepared food: make or buy? 1.

Preprepared food: make or buy? 1.


Chromatographic characterization of lachrymatory agents in tear gas aerosols.


Some dimensions of psychoneurotic behavior in an urban sample.


The origin of alveolar macrophages in mouse radiation chimeras. This investigation attempted to determine whether the primary source of alveolar macrophages is pulmonary or hematopoietic. We have utilized an antigenic marker to identify cells of hematopoietic origin. Mouse chimeras were produced by irradiating C57B6/AF(1) mice (900 R) and then injecting them intravenously with B10D2/AF(1) bone marrow. The donor animal has an antigenic specificity on the H-2 locus, not shared by the recipient. Alveolar macrophages were obtained by repeated lung washings with physiologic saline at 37 degrees C. Cytotoxic tests were done on bone marrow and alveolar macrophages using anti-31 mouse antibody, absorbed rabbit serum as complement, and trypan blue exclusion as a test for viability. Animals were studied at 7, 14, 21, 28, and 35-50 days and 4, 5, 8, and 11 months after irradiation and bone marrow replacement. By 21 days after irradiation, 90% of the animals had greater than 80% replacement of marrow with donor tissue; and white blood cell and alveolar macrophage counts approached normal. At this time and at later intervals the per cent of donor cells in the lung free cell population was not significantly different from the per cent of donor cells in the bone marrow. Similarly, after aerosol particulate exposure, the percentage of marrow cells and alveolar macrophages of donor origin were not significantly different. This immunologic approach suggests that alveolar macrophages in radiation chimeras are entirely of hematopoietic origin.


The effects of mercaptoethanol and of peritoneal macrophages on the antibody-forming capacity of nonadherent mouse spleen cells in vitro. Nonadherent mouse spleen cells exhibited poor viability and little or no capacity to form antibodies to sheep red cells in the Mishell-Dutton culture system. Viability and antibody-forming capacity could be restored by addition to these cultures of low concentrations of mercaptoethanol (10(-4)-10(-5)M), or by addition of appropriate numbers of mouse peritoneal macrophages. Macrophage concentrations lower than optimal resulted in lower lymphoid cell viability and correspondingly fewer plaque-forming cells, whereas excess macrophages resulted in marked inhibition of antibody formation despite good viability of the lymphocytes. Restoration of the nonadherent cells with mercaptoethanol was thus much simpler and more reproducible than it was with macrophages; furthermore, the number of plaque-forming cells developed in cultures restored with mercaptoethanol was approximately fourfold higher than it was in cultures restored with optimal numbers of macrophages. In the presence of mercaptoethanol, the plaque-forming capacity of the nonadherent spleen cells was not increased when small numbers of macrophages were added to the system, nor was it decreased when the few macrophages present in the nonadherent cells were further reduced or eliminated. Excess macrophages inhibited antibody formation in the cultures containing mercaptoethanol as they did in control cultures. Optimal restoration of plaque-forming capacity to the nonadherent spleen cells with mercaptoethanol required the reducing agent to be present throughout the 4 or 5 day culture period. Addition of mercaptoethanol 1 or more days after initiation of culture, or transfer of the cells to a medium free of mercaptoethanol before completion of the culture resulted in a reduction in the numbers of plaque-forming cells. The results suggest that mouse lymphoid cells do not require macrophages in order to form antibodies to sheep red cells in vitro, provided mercaptoethanol is present in the culture medium. The mechanism of action of mercaptoethanol under these conditions is not completely clear, but one of its effects is to promote the viability of lymphoid cells in the cultures.


Dr. Howard at seventy.

Dr. Howard at seventy.


Progressive intercapillary glomerulosclerosis induced by whole-body  60 Co-irradiation in the mouse.


Inhibition by atebrin (quinacrine) of model protein synthesis in vitro.


Vascular anastomoses vs. circulation across the junction, after transfer of a pedicle.


Rotation flaps, neck to cheek.

Rotation flaps, neck to cheek.


Some technical improvements in the reconstruction of the mandible and temporomandibular joint.


The classic reprint: lengthening the soft palate in cleft palate operations by George M. Dorrance, M.D., Philadelphia, Pa. Reprinted from Annals of Surgery, 82:208, 1925.


Follow-up clinic: dermatome grafting of the totally denuded testes.


Use of foam rubber sponge in tie-over dressings for skin grafting.


A skin carrier for the Padgett mesh dermatome.


Immunological approaches of leukaemia treatment.


Robert S. Schwab, MD. 1903-1972.

Robert S. Schwab, MD. 1903-1972.


Codon-anticodon interaction studied with oligonucleotides containing  3 -deazauridine,  4 -deoxyuridine or  3 -deaza- 4 -deoxyuridine. II. Ribosome binding of oligonucleotides and phenylalanyl-tRNA.


Methionine transfer RNAs from the extreme halophile, Halobacterium cutirubrum.


Functional aspects of tRNA from the extreme halophile, Halobacterium cutirubrum.


Affinity label for the tRNA binding site on the Escherichia coli ribosome.


Washington University School of Dentistry.


Mutants constitutive for nucleoside-catabolizing enzymes in Escherichia coli K12. Isolation, charactrization and mapping.


Double-stranded polydeoxyribonucleotides containing 6-thiodeoxyguanosine and 6-thiodeoxyinosine. Poly(d(A-C)-d(T-s 6 G)),poly(d(A-s 6 G)-d(T-C)) and poly(d(A-C)-d(T-s 6 I)).


Vermiculine, a new antiprotozoal antibiotic from Penicillium vermiculatum.


Effects of aminoglycoside antibiotics on initiation of viral RNA-directed protein synthesis.


A new antibiotic, gatavalin. I. Isolation and characterization.


Mechanism of inhibition of pepsin by pepstatin.


Differential diagnosis of hereditary hemolytic disorders.


Diuretics in edema: how they work; how to pick the best one.


Lymphoid depletion and immunosuppression after thymectomy in the young pig.


The anorectic effect of a long-acting preparation of phentermine (duromine).


Billroth in 1870.

Billroth in 1870.


Shunting in the lung: a two-compartment model.


Repair of the resected liver stump: an experimental study.


Anastomotic false aneurysms.

Anastomotic false aneurysms.


Serological survey of Besnoitia besnoiti (Marotel 1912) infection in Israel by immunofluorescence.


Chemotaxis and its significance for leucocyte accumulation.


Field dependence and personality structure in abnormal offenders.


Partial purification and characterization of chicken and rat follicle stimulating hormone-releasing factors.


Effects of Clomid and Sexovid on FSH and LH secretion in mature female rats.


Insulin secretion and content in isolated rat pancreatic islets following treatment with gestational hormones.


"A sentimental journey"--apologies to Laurence Sterne.


Rudolf Virchow.

Rudolf Virchow.


The contribution of George W. Bartelmez to the American School of neurology and Biological science.


Electrically elicited vocalizations in the gibbon, Hylobates lar (Hylobatidae).


The characteristic angiographic criteria of malignancy.


William Henry Neil, M.D. 9124-1972.

William Henry Neil, M.D. 9124-1972.


Effect of warm ischemic damage on intrarenal distribution of flow in preserved kidneys.


Correction of enzymatic deficiencies by renal transplantation: Fabry's disease.


Selective immunosuppression: evaluation of antigen-coated columns in an extracorporeal thoracic duct circulation.


Reactivity of lymphocytes in mixed culture in response to human renal transplantation.


Aspiration pneumonia: physiologic data following experimental aspiration.


Horizons in cardiovascular pulmonary research.


Mandibular reconstruction: bone induction in an alloplastic tray.


Mitochondria and the physiology of Ca 2+.


Pregnancy diagnosis in the ewe: a review.


Further steps in the research of cortico-hypothalamic interactions in cats. The cerebral cortex of the cat was systematically stimulated with electric shocks, and the recording of the evoked potentials in the hypothalamus was performed with macro- and microelectrodes stereotaxically guided. Stimulation of definite cortical loci evoked potentials in several hypothalamic nuclei studied. Three focuses were found, coincident with the so called "primary sensory area" of the neocortex. Hypothalamic responses elicited by stimulation of the ipsilateral cortex have greater amplitude and shorter latency than those evoked by contralateral stimulation. The "uconditioning" stimulus given on the cortex produces on the "test" stimulus response an inhibitory effect if the interstimulus delay is shorter than 0.6 sec, and a facilitatory if it is greater than 0.6 sec.


Influence of secretin and cholecystokinin on canine gastric secretion elicited by food and by exogenous gastrin.


Potentiation of the gastric secretory response to sham feeding in dogs by infusions of gastrin and pentagastrin.


Effects of secretin, cholecystokinin and caerulein on gastric secretion in response to sham feeding in dogs.


Parkinsonism, levodopa, and anesthesia.

Parkinsonism, levodopa, and anesthesia.


Accuracy of aneroid manometers used in CPPV.


On the replication of Escherichia coli DNA.


The ultrastructure of holdfasts, "rhizoids", and "slime tracks" in Thraustochytriaceous fungi and Labyrinthula spp.


Histopathological study of early skin lesions in leprosy.


Kidney in subacute endocarditis. Pathological and immunofluorescence findings.


Clinical significance of postmortem cultures.


Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma.


Exploratory laparotomy in reticulum cell sarcoma. A retrospective analysis.


Erwinia carotovora asparaginase in patients with prior anaphylaxis to asparaginase from E. coli.


Investigation of canine tissue reaction to polyurethane elastomer.


Vasectomy technic using an auto-suture.

Vasectomy technic using an auto-suture.


Insulin and metabolism: forecast of trends in research.


Influence of zinc chelate on the secretion of insulin.


Effect of KCl administration on insulin secretion in dogs.


Circulating intermediate species of proinsulin and insulin in human subjects.


Modification of glucagon-stimulated insulin secretion by surgery.


Insulin release from monolayer cultures of rat pancreatic cells: a preliminary characterization.


Effect of gastric operations on glucose homeostasis.


Glucagon secretion from the isolated perfused rat pancreas: influenced by the glucose-, tolbutamide- and pancreozymin-mediated release of pancreatic insulin.


Effect of the gastrointestinal hormones, secretin and cholecystokinin-pancreozymin, on insulin and glucagon release in healthy and diabetic subjects.


Big babies in gestational diabetics.

Big babies in gestational diabetics.


Glucose metabolism and insulin sensitivity of single fat cells.


Restoration of insulin sensitivity in the obese mouse following suppression of pancreatic islet cell hyperplasia.


Cholesterol synthesis in white adipose tissue.


Identity of native apolipoprotein in rat plasma.


Chemical diabetes mellitus in siblings of children with overt diabetes.


Divalent cation interaction in the regulation of gluconeogenesis enzymes in cellular and acellular kidney cortex systems: new data on mechanism of action of biguanides.


Growth hormone response to glucagon in diabetic and nondiabetic persons.


Remarks concerning some recent reports on therapy of diabetes.


Clinical and experimental observations on formalized insulin.


The Veterans Administration: a major resource in diabetic patient care and research.


Aspects of glucose metabolism in isolated blood capillaries.


Social criticism in art--the early cry for reform through occupational health.


Viruslike particles and inclusion bodies in penicillus cells of a mutant of Penicillium.


Infected cephalhaematoma.

Infected cephalhaematoma.


Some artifacts of the freeze-etching technique.


Canine orthotopic liver homotransplantation.


Neuropathology of intraspinal infection in mice with the Tyzzer's organism.


Escherichia coli serotypes isolated from chickens infected with Mycoplasma gallisepticum.


Photoprotection from killing in ultraviolet-sensitive Escherichia coli K-12 mutants: involvement of excision-resynthesis repair.


Modification of memory systems: some neurobiological aspects.


Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems.


Tissue cholesterol preservation: factors associated with retention of cholesterol in rat sciatic nerve fixed for electron microscopy.


Hypoxemia during and after anesthesia.

Hypoxemia during and after anesthesia.


The toxicity of oxygen.

The toxicity of oxygen.


Modification of extracapsular cataract extraction.


Mating reaction in Saccharomyces cerevisiae. II. Hormonal regulation of agglutinability of a type cells.


Regulation of carbohydrate composition of Saccharomyces cerevisiae under growth limitation.


A quick procedure for anaerobic fermentation tests in the identification of yeasts.


Studies on polylysyl-tRNA isolated from a cell-free system of Escherichia coli.


Ribosome specific binding factors of rat liver and Escherichia coli.


Who discovered the pathognomonic giant cell of Hodgkin's disease?


Drug resistance in the Swedish/Norwegian BCG strain. When a BCG strain is maintained by serial subcultures for several years, a change in its genetic properties may occur spontaneously. Such a change occurred in a strain maintained in the Norwegian State BCG Laboratory for 11 years. When received from Sweden in 1953, the strain was sensitive to the main tuberculostatics. However, in 1964, by mere chance, it was found to have become resistant to isoniazid. An examination of extant samples from the batches of freeze-dried vaccine produced during the period 1953-64 enabled the time and speed of the change to be determined. Although an alteration in drug sensitivity may not be harmful, it could cause a loss in the protective potency of a vaccine in man. It was to safeguard against this danger that the system of serial subcultures was discontinued and the seed lot system adopted, in accordance with WHO requirements.


Immunological determination of Mycobacterium leprae by means of cytoplasmic antigens. Mycobacterium leprae was isolated and purified from lepromas, the spleen, and the liver of leprosy patients. An immunodiffusion analysis of the cytoplasms obtained from four lots of M. leprae and M. lepraemurium, 295 strains of different actinomycetales, and 12 other bacteria was performed with the use of the cytoplasm antisera. Immunological relationships were revealed between the cytoplasms of M. leprae, M. lepraemurium, M. avium, M. gallinarum, M. tuberculosis, M. simiae, M. kansasii, M. chitae, M. capsulatum, Actinomyces israelii, A. naeslundii, and some strains of saprophytic mycobacteria. These studies led to the proposed concept of the immunological evolution of M. leprae and M. lepraemurium and an Actinomyces-like progenitor through M. avium-M. gallinarum and to a proposal for the polyvalent vaccine currently being developed by this research group.


Experience with percutaneous internal jugular-innominate vein catheterization. A specific technique of cannulation of the internal jugular innominate vein, presented herein, is not considered an innocuous procedure, but the incidence of serious complications is very low. In this technique a needle-in-catheter unit aids greatly in advancing the catheter through the vein. More than 62 percent of the catheters were left in place for more than five days. There was an 11.4 percent incidence of positive bacterial or fungal cultures from the catheter tip. Routine follow-up chest x-ray films demonstrated all the catheters in the innominate-superior vena cava venous system.


Critical evaluation of a new flame emission analysis system, the "Klina flame".


Organic polymer biocompatibility and toxicology.


Fifty years of medicine. I.

Fifty years of medicine. I.


Fifty years of medicine. II.

Fifty years of medicine. II.


Changes of the regional cerebral flood flow and cerebrovascular reactivity in intracranial tumours.


Acute pancreatitis.

Acute pancreatitis. FOR MANY DECADES TWO TYPES OF ACUTE PANCREATITIS HAVE BEEN RECOGNIZED: the edematous or interstitial and the hemorrhagic or necrotic. In most cases acute pancreatitis is associated with alcoholism or biliary tract disease. Elevated serum or urinary alpha-amylase is the most important finding in diagnosis. The presence of methemalbumin in serum and in peritoneal or pleural fluid supports the diagnosis of the hemorrhagic form of the disease in patients with a history and enzyme studies suggestive of pancreatitis. There is no characteristic clinical picture in acute pancreatitis, and its complications are legion. Pancreatic pseudocyst is probably the most common and pancreatic abscess is the most serious complication. The pathogenetic principle is autodigestion, but the precise sequence of biochemical events is unclear, especially the mode of trypsinogen activation and the role of lysosomal hydrolases. A host of metabolic derangements have been identified in acute pancreatitis, involving lipid, glucose, calcium and magnesium metabolism and changes of the blood clotting mechanism, to name but a few. Medical treatment includes intestinal decompression, analgesics, correction of hypovolemia and other supportive and protective measures. Surgical exploration is advisable in selected cases, when the diagnosis is in doubt, and is considered imperative in the presence of certain complications, especially pancreatic abscess.


Relationships between perfusion pressure and regional cerebral blood flow in patients with intracranial mass lesions.


Effect of low molecular dextran on total cerebral blood flow and on regional flow within ischemic brain lesions.


Prognosis of brain infarction based on blood flow measurements by means of the xenon clearance method.


Cerebral blood flow measurements after spontaneous subarachnoid haemorrhage.


Cerebral perfusion pressure correlated with regional cerebral blood flow, EEG and aortocervical arteriography in patients with severe brain disorders progressing to brain death.


Cerebral blood flow and oxygen uptake in patients with brain lesions.


rCBF and intracranial pressure in comatose patients.


Effect of prostaglandin E 1  on cerebral circulatory disturbances.


Description and early results of an intravenous radioisotope technique for measuring regional cerebral blood flow in man.


The use of the xenon clearance method in subarachnoid haemorrhage.


The biological significance of the histocompatibility antigens. Report on a colloquium held at titisee (schwarzwald) October 14-15, 1971.


Further studies on the ABO-typing of ancient bones.


Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme.


Caring for nursing home patients--learning experience for dental students.


Problems in everyday inhalation therapy and their solutions.


Arteriovenous fistulas following renal biopsy with hypertension and hemodynamic changes: report of a case studied by dye-dilution technique.


Double ureters in renal transplantation.


External ureteroneocystostomy in renal transplantation.


Ammonia encephalopathy secondary to ureterosigmoidostomy: a case report.


Testicular prosthesis: a new insertion operation.


The management of severe inflammatory and traumatic injuries to the genital skin.


Motility of spermatozoa in the human epididymis.


Accidental penile gangrene.

Accidental penile gangrene.


Retropubic urethrovesical plication and suspension for total incontinence following surgery upon the vesical neck.


Repair of chronic patellar luxation.

Repair of chronic patellar luxation.


Hippocampal destruction in man and other animals.


Comparative study on local blood flow determination by means of hydrogen.


The NIMH collaborative depression studies--a progress report.


Effects of oral terbutaline in asthmatic patients. A dose response study.


Use of the immunofluorescence method for the serotype identification of Borrelia anserina (Sakharoff, 1891) strains.


Haemopoietic aspects of the changes in the natural radiation resistance of mice after hypoxia.


On the theory and practice of shaking infants. Its potential residual effects of permanent brain damage and mental retardation.


The body build of patients with slipped capital femoral epiphysis.


Neonatal magnesium disturbances.

Neonatal magnesium disturbances.


Advances in sterilization techniques: state of the art and recent breakthroughs.


Stability of frozen solutions of sodium cephalothin and cephaloridine.


Diseases of cellular immunity.

Diseases of cellular immunity.


Intracardiac electrocardiography in the analysis and understanding of cardiac arrhythmias.


Irreversible renal failure secondary to hypertension induced by oral contraceptives.


Management of arterial injury secondary to attempted subclavian vein catheterization.


5-fluorocytosine in the treatment of mycotic infections.


Radical right pneumonectomy using preserved allograft vein for caval replacement.


Clinical analyses of factors influencing L-dopa treatment of Parkinson's syndrome.


Cardiac pacemaker wound infection.

Cardiac pacemaker wound infection.


Randomization and coronary artery surgery.


Double-blind study of the efficacy of a soluble rutoside derivative in the treatment of venous disease.


Hypothalamic releasing factors: a new class of "neurotransmitters".


Effects of CH 13.437 in different types of hyperlipidemia.


The role of calcium in the action of drugs on vascular smooth muscle.


Further studies on diplopodia. V. Diplopodia-3.