Filamentous bacterial viruses. VII. Inhibition of fd deoxyribonucleic acid synthesis after a temperature jump into protein-synthesis inhibitors. Synthesis of fd deoxyribonucleic acid (DNA) was stopped by transferring infected bacteria from 32 C into chloramphenicol or serine hydroxamate at 42 C, but not by addition of these antibiotics at 32 C, and not by a temperature change in the absence of antibiotics. The inhibition of fd DNA synthesis by serine hydroxamate at 42 C was reversed by excess serine. The ability to synthesize fd DNA at 42 C in chloramphenicol was rescued by delaying the addition of chloramphenicol for a few minutes after the transfer from 32 to 42 C. The colony-forming ability of abortively infected bacteria was also rescued from "killing" by delaying the addition of chloramphenicol after a transfer from 32 to 42 C.


Reconstruction of the oral cavity.

Reconstruction of the oral cavity.


Reconstruction of the hypopharynx and cervical esophagus.


Bone and cartilage grafts: current concepts.


Nasal reconstruction using pedicle skin flaps.


Reconstruction of the mandible.

Reconstruction of the mandible.


Transposed and interposed flaps in head and neck surgery.


Survey of the use of composite grafts in the head and neck region.


Regional flaps. Principles and application.


Facial reanimation in facial paralysis.

Facial reanimation in facial paralysis.


The reconstructive potential of vascular pedicled muscle flaps.


Contemporary surgical techniques in orofacial reconstruction.


Reconstruction of the burned ear.

Reconstruction of the burned ear.


Subcellular localisation of noradrenaline in sympathetic neurons.


Immunoelectrophoretic studies on extracts principally derived from porcine strains of Escherichia coli.


The effect of the method of whey preparation on the clarity of whey and the Salmonella whey agglutination titre.


Asymmetric transcription of the coliphage P2 genome during infection.


Evidence that more deoxynucleotide kinase mRNA is transcribed than translated during T4 infection of Escherichia coli.


Transient depression in the active transport across the membrane of Salmonella typhimurium, after infection with bacteriophage P22.


Properties of polylysogens containing depressed lambda N- prophages. II. The number of prophages affects bacterial viability.


Phage-like structures (SE-particles) in cells of the unstable and stable spheroplast type L-form of Proteus mirabilis D 52.


The long-term preservation of bone marrow.


Intraoperative blood transfusions and hyperacute renal allograft rejection in a presensitized recipient.


Electroencephalographic and histopathological changes resembling Jakob-Creutzfeldt disease after transient cerebral ischemia due to cardiac arrest.


Juvenile cerebral arteriosclerosis and other cerebral arteriopathies of childhood--six autopsied cases.


Subacute dysautonomia with incomplete recovery.


Pulmonary blood- and extravascular water volumes during prolonged post-hemorrhagic systemic hypotension.


On the threshold of biologic engineering.


Cytology of urine from dogs with botryoid sarcoma of the bladder.


Timely topics in clinical chemistry: 1971.


Y-chromatin of interphase cancer cells, a preliminary study.


Experiences with respect to intraoperative cytodiagnosis.


Amino acid sequences in the  -chains of adult bovine hemoglobins C-Rhodesia and D-Zambia.


Chemical evidence for identical subunits in L-asparaginase from Escherichia coli B.


Lithium carbonate in emotionally unstable character disorder.


The ionic strength dependence of S 0 20.w for DNA in NaCl.


Automated analyses of serum cholesterol and triglycerides in a multiphasic screening program.


Studies on lytic activities of Chondrococcus coralloides (Myxobacterales). II. Identification of the bacteriolytic enzyme as a muramidase.


High shear rate viscosity measurements with dilute solutions of bovine fibrinogen.


The effect of certain dietary factors on in vivo pH changes and pepsin activity in the stomach of the growing pig.


Fat metabolism in higher plants. LIV. A procaryotic type acetyl CoA carboxylase in spinach chloroplasts.


Computer assisted analysis of a carrier culture infected with Moloney leukemia virus.


Nuclear dry mass and area of human buccal mucosa cells in normal and air dried smears.


Hemodynamic data and angiographic findings after Mustard repair for complete transposition of the great arteries.


The karyotype of the pig (Sus scrofa domestica), identified by quinacrine mustard staining and fluorescence microscopy.


The C-band and G-band patterns of Microtus agrestis chromosomes.


The Scandinavian Acta.

The Scandinavian Acta.


Organophosphorus pesticides: residues and metabolism.


"Itai-itai byŏ" and other views on cadmium.


Relationship among tumorigenicity, T antigen, and virus-specific transplantation antigen in adenovirus type 12 transformed and tumor cells.


Shape and motility of cultured human lymphoblastoid cells.


Effect of 2,2'-O-cyclocytidine on transplanted lymphocytic sarcoma and reticulum cell sarcoma in mice.


Purine studies. VII. The synthesis of purines as amplifiers of phleomycin against E. coli.


Histological observations on allografts and reciprocal xenografts in newts (Notophthalmus viridescens) and axolotis (Ambystoma mexicanum).


Aspects of liver transplantation.

Aspects of liver transplantation.


Pancreatic transplantation.

Pancreatic transplantation.


16-Unsaturated C 19  steroids. A review of their chemistry, biochemistry and possible physiological role.


A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.


A controlled trial of hydrocortisone therapy in infants with respiratory distress syndrome.


Fables for the instruction of youth published in Boston in 1818. Excerpt IV. Dog and the ox.


Calculation methods and model experiments for the determination of the parameters of third (peripheral) mixing chambers using the isotope dilution technique.


Subtraction technique of extraneous contributions in external recordings: application to liver function. Study with 131-I rose bengal.


Intestinal absorption of aromatic amino acids in senescence.


The study of intestinal digestion and absorption in stress conditions. Investigations by means of 14 C-stearic acid and 131 I-triolein.


LSD psychotherapy: a review of the literature and some proposals for future research.


Solomon Drowne and the Gaspee affair.

Solomon Drowne and the Gaspee affair.


List of members of the Association of Life Insurance Medical Directors.


Effect of oxygen breathing on local blood flow in human adipose tissue.


American Association of Anatomists. Sustaining associate members. 1971-1972.


Spirometry studies in patients awaiting surgery.


A critical appraisal of some recent in-vitro diagnostic tests for immediate hypersensitivity. The rat mast cell test revisited.


Hysteresis and conformational changes in ribosomal ribonucleic acid. Both rat liver and Escherichia coli rRNA in 0.1m-sodium chloride were titrated with acid or alkali over the range pH3-7 at approx. 0 degrees C. rRNA did not bind acid reversibly and hysteresis was observed, i.e. the plot of acid bound to rRNA against pH had the form of a loop showing that the amount of acid bound at a particular pH depended on the direction of the titration. Although the boundary curves were reproducibly followed on titration from pH7 to 3 and from pH3 to 7, points within the loop were ;scanned', e.g. by titration from pH7 to a point in the range pH3-4 followed by titration with alkali to pH7. It is inferred that the ;lag' in the release of certain bound protons is at least 1 pH unit, that at least about 9-15% of the titratable groups (adenine and cytosine residues) that are involved in this process and that the free energy dissipated in completing a cycle is approx. 4.2kJ/mol (1kcal/mol) of nucleotide involved in hysteresis. The interpretation of the ;scanning' curves was illustrated by means of a cycle of possible changes in the conformation of a hypothetical nucleotide sequence that allows formation of poly(A).poly(AalphaH(+))-like regions in acidic solutions. It is also inferred that the extent of ;hysteresis' might depend on the primary nucleotide sequence of rRNA as well as on secondary structure.


Georges Teissier 1900-1972.

Georges Teissier 1900-1972.


A physiological basis for the development of opportunistic infections in man.


Production of antibodies to placental antigens by pregnant ewes experimentally infected with Aspergillus fumigatus.


An endodeoxyribonuclease induced after infection with phage T7 bearing amber mutations in genes 3, 5, and 6.


Metabolic clearance of insulin in man.

Metabolic clearance of insulin in man.


The UGDP controversy. Clinical trials versus clinical impressions.


Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.


Factors influencing the effect of an adjuvant on the growth of solid isogeneic tumors.


Clinical trial of 2-Br- -ergocryptine (CB154) in advanced breast cancer.


Electrophoretic pattern of sera of normal and cancer patients.


Clinical trial of the cyclic imide 1-(morpholinomethyl)-4-phtalimido-piperidindione-2,6 (CG 603) in advanced breast cancer.


Clinical trial of nafoxidine, an oestrogen antagonist in advanced breast cancer.


Biological efficacy of several commercially available peptones for mammalian cells in culture.


Consistent pattern of binding of anti-adenosine antibodies to human metaphase chromosomes.


The action mechanism of cerulenin. I. Effect of cerulenin on sterol and fatty acid biosynthesis in yeast.


Interconversion of high- and low-spin states of cytochrome p-450 solubilized from yeast microsomes.


Elution of antibodies from immunoadsorbents: effect of dioxane in promoting release of antibody.


The conjugation of immunoglobulins with tetramethylrhodamine isothiocyanate. A comparison between the amorphous and the crystalline fluorochrome.


Mycoplasma pneumoniae infection: a review.


Structure of straight flagella from a mutant Salmonella.


Stimulation of in vitro RNA synthesis by ribosomes and ribosomal proteins.


Initial step of excision repair in Escherichia coli: replacement of defective function of uvr mutants by T4 endonuclease V.


Changes in staff anxiety and attitudes during a double blind study of haloperidol in acute schizophrenics within a structured milieu.


Differential inhibition of coliphage MS2 protein synthesis by ribosome-directed antibiotics.


Assessment of the nature of reticuloendothelial contribution during endotoxicosis in mice.


Role of macrophage in antibody formation--significance of lymph node cells contacting the antigen-ingesting macrophage.


The computer as a "living textbook" applied to the care of the critically injured patient.


Endotoxins and leukocyte mobilization.

Endotoxins and leukocyte mobilization.


The effect of interstitial edema on pulmonary function in the dog.


Verrucous carcinoma. Report of three vulvar cases and review of the literature.


Evaluation of a new pregnancy test. Pregnosticon Dri-Dot.


Bent knee pylon for the below-knee amputee.


Infectious mononucleosis and reticulum cell sarcoma.


A review of some effects on health and performance of variations in the physical form of the diet of the growing pig. I. Cereal processing.


Current status of intrathecal radiogold in the treatment of medulloblastoma.


J.J. Woodward (1870) on the histology and photomicrography of minute blood vessels.


Medicine and the mass media.

Medicine and the mass media.


Antipeptic activity of a sulfate glycopeptide different behavior with purified human pepsin or human gastric juice.


Escherichia coli alkaline phosphatase. Kinetic studies with the tetrameric enzyme. 1. The stability of the tetrameric form of Escherichia coli alkaline phosphatase was examined by analytical ultracentrifugation. 2. The stopped-flow technique was used to study the hydrolysis of nitrophenyl phosphates by the alkaline phosphatase tetramer at pH7.5 and 8.3. In both cases transient product formation was observed before the steady state was attained. Both transients consisted of the liberation of 1mol of nitrophenol/2mol of enzyme subunits within the dead-time of the apparatus. The steady-state rates were identical with those observed with the dimer under the same conditions. 3. The binding of 2-hydroxy-5-nitrobenzyl phosphonate to the alkaline phosphatase tetramer was studied by the temperature-jump technique. The self-association of two dimers to form the tetramer is linked to a conformation change within the dimer. This accounts for the differences between the transient phases in the reactions of the dimer and the tetramer with substrate. 4. Addition of P(i) to the alkaline phosphatase tetramer caused it to dissociate into dimers. The tetramer is unable to bind this ligand. It is suggested that the tetramer undergoes a compulsory dissociation before the completion of its first turnover with substrate. 5. On the basis of these findings a mechanism is proposed for the involvement of the alkaline phosphatase tetramer in the physiology of E. coli.


Correlation between hexose transport and phosphotransferase activity in Escherichia coli.


Formation of di-D-fructofuranose I,2':2,3' dianhydride from inulin by an extracellular inulase of Arthrobacter ureafaciens.


Inhibition of the  -lactamases of Escherichia coli and Klebsiella aerogenes by semi-synthetic penicillins. 1. A new automated micro-iodometric method is described for screening compounds for inhibitory action against beta-lactamase enzymes. 2. Over 1000 semi-synthetic penicillins were tested for inhibitory activity against the beta-lactamase of Escherichia coli B11 and 18 showed a fractional inhibition similar to or higher than that of methicillin. 3. The best inhibitors were alkoxy- and halogen-substituted phenyl-, naphthyl- or quinolyl-penicillins. 2-Isopropoxy-1-naphthylpenicillin (BRL 1437) was clearly the best and had a K(i) value about 1% of that of methicillin. 4. The inhibition of the beta-lactamase of E. coli B11 by BRL 1437 was shown to be reversible and competitive. The K(i) was 0.004mum and K(i)/K(m) with ampicillin and p-hydroxyampicillin (BRL 2333) was about 0.0001. The K(m) and V(max.) values were determined for the beta-lactamases of E. coli B11 and Klebsiella aerogenes A against a variety of penicillins. Cell-bound and solubilized enzymes gave similar K(i) and K(m) values. 5. BRL 1437 was superior to cloxacillin and methicillin for inhibition of the beta-lactamase of live, fully grown cultures of several strains of E. coli and K. aerogenes. Of a group of inhibitors BRL 1437 was the most stable to the beta-lactamase of E. coli B11.


A placebo-controlled trial of imipramine in nonspecific vasomotor rhinitis.


Double-blind trial of oral zinc sulphate in patients with leg ulcers.


Double-blind trial of lorazepam for anxiety in general practice.


Social imitation--a neglected factor in psychotherapy?


Clonidine for migraine.

Clonidine for migraine.


Reticuloendothelial and hepatic functional alterations following lead acetate administration.


Induction of petite mutants in Saccharomyces cerevisiae by ICR-170 and their genetic characterization.


Somatic segretation, recombination, asymmetrical distribution and complementation tests of cytoplasmically-inherited antibiotic-resistance mitochondrial markers in S. cerevisiae. Genetic analyses of 48-hr-old zygote-daughter-colony cells from crosses between chloramphenicol and erythromycin resistance markers located in mitochondrial DNA demonstrated homoplasmons of parental and recombinant genotypes, and heteroplasmons with recombinant and/or parental genotypes. Although the heteroplasmons were unstable and the homoplasmic components could be segregated by plating on selective media, the heteroplasmic state was often maintained beyond 19 cell divisions when grown on non-selective medium. Homoplasmons of recombinant genotype from repulsion crosses were observed with a frequency of 7.2, 9.0, 11.2 and 11.4 percent; two crosses with the resistance markers in coupling had 5.4 and 11.5 percent recombinants. Under non-selective conditions, the mitochondrial marker derived from the haploid parent of a mating type predominated in zygote-daughter-cells; this asymmetrical distribution could be reversed by selective pressure for the marker transmitted with low frequency. The challenge with chloramphenicol and erythromycin of zygotes from crosses of resistance-markers in repulsion revealed that inter-mitochondrial complementation was not occurring.


An improved histochemical method for the demonstration of disaccharidases with natural substrates.


Freud and hypnosis: a reevaluation.

Freud and hypnosis: a reevaluation.


Prevention of dissipation of health services resources.


Thermography in plastic surgery.

Thermography in plastic surgery.


Effect of rifampin on the growth of bacteriophage T5. A rifampin-resistant mutant of Escherichia coli F with an altered ribonucleic acid (RNA) polymerase was isolated and was shown to support the growth of phage T5 in the presence of rifampin. In contrast, wild-type, rifampin-sensitive cells of E. coli F did not support the growth of T5 in the presence of rifampin. We concluded, therefore, that no phage-specific RNA polymerase is essential to the development of phage T5. Rather, the host RNA polymerase, or at least that portion of the host RNA polymerase that is responsible for rifampin sensitivity, is required for the transcription of all essential regions of the T5 deoxyribonucleic acid. These conclusions are supported by in vitro measurements of the rifampin sensitivity of the RNA polymerase activities extracted from infected and uninfected cells. The rifampin sensitivity of the RNA polymerase activity extracted from uninfected cells was similar to the rifampin sensitivity of the RNA polymerase activity extracted 30 min after infection.


Defective deoxyribonucleic acid replication of T4rII bacteriophage in lambda-lysogenic host cells. Sedimentation of the replicative deoxyribonucleic acid through alkaline sucrose gradients showed that rII single chains reached the half-mature size at a time when wild-type molecules formed long chains (dimers and trimers of genome size). Long rII single chains could be observed on substitution of tris(hydroxymethyl)aminomethane buffer for Na(+)K(+) phosphate in the growth medium.


A history of venereal diseases.

A history of venereal diseases.


The Rachel Forster Hospital jubilee.

The Rachel Forster Hospital jubilee.


Management of the pediatric surgical patient.


Rachel Forster Hospital, 1922 to 1972: the founders.


Urinary tract infections in children. I. Clinical features, urinary collection and interpretation, investigations.


Thomas Roy Edmeades.

Thomas Roy Edmeades.


David Zacharin.

David Zacharin.


Raymond Victor Dan.

Raymond Victor Dan.


Antihyperlipidaemic effects of renal transplantation and antilymphocyte globulin in uraemic hyperlipidaemia.


Renal immunohistology.

Renal immunohistology.


Reversible dissociation of threonine deaminase in an ilvl mutant of Saccharomyces cerevisiae.


Specific enrichment of mutants of Escherichia coli with an altered acyl CoA synthetase by tritium suicide.


Temperature sensitive initiation of DNA synthesis in a mutant of Salmonella typhimurium.


Pyrimidine dimers as pre-mutational lesions in Escherichia coli WP2 Hcr.


Suppression of promoter mutations by the pleiotropic supx mutations.


The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants.


A statistical aid to the diagnosis of keratoconjunctivitis sicca.


Indicanuria after gastric surgery. An evaluation in the diagnosis of the blind-loop syndrome.


Stereotaxic congulomotomy and prefrontal lobotomy in mental disease.


A review of the treatment of canine renal disease.


The fine structure of the paracervical (Frankenhäuser) ganglion of the rat after permanganate fixation.


Infected cephalhaematoma.

Infected cephalhaematoma.


Studies on various aspects of the indirect haemagglutination test for malaria. This paper gives the results of studies on various technical aspects of the indirect haemagglutination (IHA) test for malaria, on the similarity of the results obtained in the IHA test and in the indirect fluorescent antibody test, on the use of various plasmodial extracts as sensitizing antigens in the IHA test, and on the influence of heterophile antibodies on the titres obtained in the IHA test. Some longitudinal observations on induced malaria infections of man and monkey showed that the infection can induce the production of heterophile antibodies: their appearance, however, remains unpredictable. In some infections agglutinins against host erythrocyte components are also produced. Absorption of sera with tanned sheep cells sensitized with noninfected host red blood cell antigens is advocated as a control on the IHA titre for specific agglutinins.


The importance of dynamic preservation in cadaver renal transplantation.


A test for the determination of competency in clearing bacilli in leprosy patients. A skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. The test involves the intradermal injection of a suspension of killed Mycobacterium leprae. The response of leprosy patients to the injection of other mycobacterial antigens, one prepared from M. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in order to study the isopathic phenomenon. Since lepromatous patients react negatively in tests with standard Mitsuda antigen, a concentration of 640 x 10(6)M. leprae per ml was used to produce macroscopic responses. The results of the test can be applied to determine the duration of consolidation treatment for lepromatous and indeterminate bacteriologically negative patients after regular treatment has ended. The test can also be used to indicate which Mitsuda-negative contacts should be given preventive treatment, and might be used to identify a given mycobacterium as M. leprae.


Short time kidney preservation by hypothermic oxygen persufflation.


Abnormal rate of granule cell migration in the cerebellum of "Weaver" mutant mice.


Pulmonary allografts in the dog: function the first year.


Experimental preservation of liver from hypotensive donor and with prolonged warm ischemia.


Pulmonary artery-portal vein shunt. Experimental studies of a new surgical shunt procedure.


Canine lung allografts during rejection.


Research, regulation turn on waste anesthetics.


Effect of guanidine hydrochloride on circular dichroism of yeast tRNA.


Anomalous behavior of heavy meromyosin-F-actin solution at low velocity gradients.


Influence of hormones on enzyme activity in mouse mammary gland in vitro.


Mechanism of secretion of the aqueous phase of milk.


Electron microscopic studies on developing cartilage. II. Demonstration and distribution of glycogen in chick and mouse epiphyseal cartilage.


Valence and temporal change in affinity of purified 7S and 18S nurse shark anti-2,4 dinitrophenyl antibodies.


Cross-reactions of HL-A antibodies. II. Continuous pH gradient elution.


Lymphocyte classes in New Zealand mice. II. Decreased frequency of immunoglobulin-bearing lymphocytes and increased frequency of lymphocytes lacking detectable theta or immunoglobulin determinants.


Immunoglobulins on the surface of lymphocytes. V. Quantitative studies on the question of whether immunoglobulins are associated with T cells in the mouse.


Use of dextran-conjugated SRBC for the detection of MOPC 104E tumor cells.


Host defense against bacterial endotoxemia-contribution of the early and late components of complement to detoxification.


Effect of ratio of roughage to concentrate and level of feed intake on ovine ruminal vitamin B 12  production.


Presence of rheumatoid factor in ten children with isolated rheumatoid-like nodules.


Malabsorption syndromes in infancy and childhood. I.


Infantile cortical hyperostosis of the scapula presenting as an ipsilateral Erb's palsy.


Arthritis as a presenting manifestation of malignancy in children.


Effect of topical papaverine in preventing thrombosis following arteriotomies. A double-blind study in infants and children.


The value of the standardized interview for the evaluation of psychopathology.


The effect of hyperventilation on maternal placental blood flow in pregnant rabbits. 1. In anaesthetized pregnant rabbits near term, cardiac output and its distribution were measured by injection of isotope-labelled microspheres. Hypocapnia (mean arterial P(CO) (2) 18 mm Hg), induced by intermittent positive pressure hyperventilation, caused a 43% reduction in maternal placental blood flow, attributed mainly to vasoconstriction. Myometrial flow was not significantly changed.2. Moderate hypercapnia (mean arterial P(CO) (2) 46 mm Hg) caused no change in placental flow, compared with observations made while breathing air spontaneously (P(CO) (2) 31 mm Hg).3. Intravenous infusions of adrenaline or noradrenaline 1 mug/kg. min caused maternal placental vasoconstriction.4. During the especially warm summer of 1969, there was a mean 46% reduction in maternal placental blood flow in pregnant rabbits near term, breathing room air spontaneously with normal blood gas values and rectal temperatures. This was associated with an increase in the number of runts and dead foetuses.


A man to remember, E. Fauré-Fremiet (1883-1971): three-quarters of a century of progress in protozoology.


Chromatic sensitivity and spatial organization of LGN neurone receptive fields in cat: cone-rod interaction. 1. The results described are for detailed analyses of fifty-four isolated LGN units, in response to monochromatic stimuli presented against achromatic, mid-mesopic backgrounds. Forty-seven were positively identified cells from the A-laminae; the remaining seven were fibres from the optic radiation.2. Cells are classified according to firing pattern. Phasic cells respond almost exclusively with a discharge transient. Tonic cells, by contrast, give a maintained component in addition. In general, tonic cells possess higher spontaneous firing frequencies than phasic cells and the antagonistic surrounds of their receptive fields are more potent. In other respects the two classes appear to be functionally similar.3. All cells within the A-laminae receive input involving both rods and 556 nm cones.4. The spatial organization of geniculate receptive fields, unlike retinal fields, is little different for cone and rod vision. In the infrequent instances where a change is apparent, it is small and can go in either direction: rod fields are then on balance slightly larger than cone fields.5. The locus of maximum sensitivity for the receptive field surround is described by a circle, concentric with the field centre; it is invariant with respect to stimulus geometry, or changeover from cone to rod vision.6. This result implies that the receptive field surround mechanism does not extend through the field centre. It supports the notion that the centre and surround of each geniculate cell receptive field are mediated by discrete retinal inputs.


Diagnostic pathways in general practice.


Rosette arrangement of electron-dense structures of granulomatous alveolar macrophges.


Failure of poly (I-C) to enhance killing of Escherichia coli by mouse peritoneal macrophages.


Solute-gel interactions in gel filtration.


Exchange of cadaveric kidneys for transplantation.


Carcinoembryonic antigen.

Carcinoembryonic antigen.


Lengthy surgical scrubs may not be necessary for all O.R. personnel, new study indicates.


ECG by wire: diary of a coronary.

ECG by wire: diary of a coronary.


Stimulation of mutation in phage T 4  by lesions in gene 32 and by thymidine imbalance.


Analysis of photoenzymatic repair of UV lesions in DNA by single light flashes. IX. Excess production of photoreactivating enzyme in E. coli B s-1- 160 under different growth conditions, and its suppression by adenine.


The action of caffeine on the survival of proteus mirabilis and its virulent phage VIr after UV-irradiation and treatment with nitrogen mustard.


Enhanced initiation factor activity in rats after administration of 3-methylcholanthrene or  -naphthoflavone.


The stability of DDT.

The stability of DDT.


Mutagenic activity of isoniazid and hydrazine in mammalian test systems.


Myeloperoxidase-mediated iodination in granulocytes.


Surface-bound immunoglobulin on lymphocytes from normal and immunodeficient humans.


On the origin of "isozymes" of inorganic pyrophosphatase obtained from baker's yeast.


A review of early events in tubercle formation.


Renal biopsy findings in familial amyloidosis with corneal lattice dystrophy. An immuno-histochemical, light-microscopical and electron-microscopical study.


Monoamine oxidases--new vistas. Introduction and historical background.


Multiple forms of monoamine oxidase and their properties.


Neuronal monoamine oxidase: specific enzyme types and their rates of formation.


Comparative aspects of coronary collateral circulation.


Claude Bernard: experimental physiologist and teacher.


The influence of maternal antibodies on the epidemiology of leptospiral carrier state in mice.


Status of malaria eradication in the Americas.


The research and development of serologic tests for malaria.


The epidemiologic interpretation of serologic data in malaria.


The immunologic response to plasmodium.

The immunologic response to plasmodium.


Sporozoite-induced immunity in mammalian malaria. A review.


The problem of drug-resistant malaria.

The problem of drug-resistant malaria.


Development of new antimalarial drugs.

Development of new antimalarial drugs.


The influence of plants on anopheline breeding.


The influence of vector behavior on malaria transmission.


Discussion of contemporary malaria research needs as reflected in the symposium.


Hemadsorption plaque assay for hemagglutinating encephalomyelitis virus.


Rejection of human renal homografts: basic mechanisms and terminology.


Sanitary legislation in New York, 1861.

Sanitary legislation in New York, 1861.


Hydrostatic pressure effects on protein synthesis. The effects of high hydrostatic pressure on several phases of cell-free protein synthesis have been examined. The initial rate of polyuridylic acid (poly U)-directed synthesis of polyphenylalanine showed an apparent increase at 100 atm, above which the synthetic rate was reduced sharply with increased pressure up to 640 atm where 95% inhibition was observed. The magnitude of the inhibition of polyphenylalanine synthesis with increased pressure depended strongly on the magnesium salt concentration in the reaction system. Misreading of the poly U message, as measured by insertion of leucine in place of phenylalanine, dropped rapidly with increased pressure from 1 to 350 atm, above which the amount of misreading increased. Enzymatic activation of transfer RNAs (tRNAs) was reduced by increased pressure in the range 100-640 atm, where the rate of tRNA aminoacylation was 80% inhibited. Both nonenzymatic attachment of phenylalanyl-tRNA (phe-tRNA) to the poly U-ribosome complex and stability of the phe-tRNA-poly U-ribosome complex were decreased at high pressures (100-900 atm). The results of the action of pressure on the various phases of cell-free protein synthesis suggest that the major pressure-sensitive element in the protein synthetic machinery is the ribosome.


Immune therapy of malignant melanoma.

Immune therapy of malignant melanoma.


Hazards of artificial ventilation in the operating room.


The first decade (VI).

The first decade (VI).


Methods for the microbiological control of non sterile drugs.


Current concepts in antepartum and intrapartum fetal evaluation.


Clifton J. Latiolais, APhA president.

Clifton J. Latiolais, APhA president.


Analysis of hallucinogenic drugs.

Analysis of hallucinogenic drugs.


Fibrinous synovitis in calves inoculated with killed Mycoplasma mycoides. Elevated plasma fibrinogen concentration and increased permeability of the synovium.


Methods for the analysis of narcotic analgesics and amphetamines.


Reaction to killed Mycoplasma mycoides in joints in specifically sensitized calves.


Effect of Escherichia coli endotoxins on plasma para-phenylenediamine oxidase (caeruloplasmin) activity in the domestic fowl.


Urinary C-reactive protein and lysozyme in renal homotransplantation.


Corynebacterium renale as a cause of reactions to the complement fixation test for Johne's disease.


Mortality books for 1820 to 1849 from the Parish of St. Bride, Fleet Street, London.


A salute to Professor Ackerknecht upon retirement.


Public health in colonial New Haven.

Public health in colonial New Haven.


The 'minor' hemisphere.

The 'minor' hemisphere.


Development of Arabic medical therapy in the tenth century.


The circumcision: copperplate engraving (1549) by Heinrich Goltzius (1558-1617).


Dr. Samuel Gelston (1727-82), variolator, and his son, Dr. Roland Gelston (1761-1829), vaccinator, from Nantucket.


Basement-membrane turnover in the rat.

Basement-membrane turnover in the rat.


Elevated rates and altered characteristics of the clearance of carbon from the blood of rabbits with variations in environmental conditions.


Treatment of malignant neoplasia. Surgical management.


Quality in general practice. A commentary on the quality of care provided by general practitioners.


Ampicillin-resistant Shigella sonnei.

Ampicillin-resistant Shigella sonnei.


Methadyl acetate vs methadone. A double-blind study in heroin users.


Electron microscopy of ferritin-labeled platelet-specific antibody.


Bruce Hunter Anderson.

Bruce Hunter Anderson.


The pleural space and pleural fluid.

The pleural space and pleural fluid.


Comparative trial of fungilin (amphotericin B) and pimafucin (natamycin) pessaries in the treatment of vaginal candidiasis.


Computers in clinical medicine.

Computers in clinical medicine.


Dr. Henry Stanley Plummer (1874-1936) (historical vignette).


Acute respiratory failure in the adult. 1.


Treatment of micrognathia in the neonatal period. Report of 65 cases.


Potential pitfalls in the use of the deltopectoral flap.


Psychotropic drugs.

Psychotropic drugs.


Tycho Brahe and his sixteenth century nasal prosthesis.


Nipple and areola reconstruction by split-skin graft from the normal side.


Split-rib mandibular reconstruction.

Split-rib mandibular reconstruction.


The Kutler repair for fingertip amputations.


Predicting the extent of viability in flaps by measurement of gas tensions, using a mass spectrometer.


Autogenous en bloc transplantation of the mammary gland in dogs, using microsurgical technique.


The classic reprint. Die Transplantation Betreffend by Prof. Otto Lanz.


Intravascular coagulation--acute and chronic--disseminated and local.


Franklin B. McCarty, 1888-1972.

Franklin B. McCarty, 1888-1972.


J, Kenneth Sokol. 1911-1972.

J, Kenneth Sokol. 1911-1972.


Frank Victor Theis. 1889-1972.

Frank Victor Theis. 1889-1972.


Stewart Craig Thomson. 1905-1972.

Stewart Craig Thomson. 1905-1972.


Institute of Medicine of Chicago.

Institute of Medicine of Chicago.


Aggregation in vitro of immature thrombocytes from early chick embryos.


Retention over time in relation to arousal during learning: an explantation of discrepant results.


Personality and system influences on behavior in groups: frequency models.


Einthoven, G.J. Burch, and the capillary electrometer.


Evaluation of various media for growth of selected pathogenic fungi and Nocardia asteroides.


Antibiotic prophylaxis in cataract surgery.


Control of intraocular pressure in penetrating keratoplasty.


An unusual case of reticulum cell sarcoma.


Regulation of pepsin secretion by topical acid in the stomach.


Cardiovascular responses to electrical stimulation of the septum in the rat.


William Ross Sidman, B.V.Sc.,F.RA.C.V.Sc.


Molecular hybridization of ribonucleic acid with a large excess of deoxyribonucleic acid. When RNA is annealed in solution with a sufficiently large excess of DNA, the kinetics of DNA-RNA hybridization are relatively simple. Methods are described for following the course of both DNA renaturation and DNA-RNA hybridization in this system. To explore the characteristics of the reaction a series of model systems was used. Each one utilized DNA (sheared to constant size) from a bacterium or bacteriophage and homologous cRNA, i.e. RNA synthesized in vitro on a template of the same DNA. Temperature optima were determined for the hybridization of Escherichia coli nucleic acids in 2xSSC and 3xSSC-50% formamide buffers, and of Proteus mirabilis nucleic acids in 2xSSC buffer. Rate-constants for DNA-RNA hybridization were measured by two methods. These gave somewhat different results, but in all cases the rate-constant of DNA-RNA hybridization was clearly less than that of DNA renaturation. Thus hybridization is a slower reaction than DNA renaturation. Nevertheless, in some cases, with a high concentration of DNA and a long annealing time, 90-95% of the added RNA became resistant to ribonuclease. Experiments are described which show that it is possible to deduce the analytical complexity of DNA with reasonable accuracy from its hybridization with complementary RNA. Similarly, it is possible to estimate the reiteration frequency of multiple DNA sequences (such as ribosomal DNA) from the hybridization of the total DNA with RNA complementary to the multiple sequences. The effect on the system of various DNA/RNA ratios from 100 to 1 is described.


The purification and some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Baker's yeast. 1. A purification of 3-hydroxy-3-methylglutaryl-CoA synthase from baker's yeast is described. This yields a preparation of average specific activity 2.1 units (mumol/min)/mg in which contamination by acetoacetyl-CoA thiolase is less than 0.2%. 2. The molecular weights of 3-hydroxy-3-methylglutaryl-CoA synthase and acetoacetyl-CoA thiolase from baker's yeast were determined by gel filtration on Sephadex G-200. The values obtained were 130000 and 190000 respectively. 3. 3-Hydroxy-3-methylglutaryl-CoA synthase is susceptible to irreversible inhibition by a wide variety of alkylating and acylating agents. The time-course of inhibition of the enzyme by some of these, including the active-site-directed inhibitor bromoacetyl-CoA, was studied in the presence and absence of substrates, products and product analogues. Acetyl-CoA, even when present at concentrations as low as 5mum, gives almost complete protection. Other acyl-CoA derivatives give some protection, but only at concentrations 10-30-fold higher. 4. These results are discussed with reference to an ordered reaction pathway in which acetyl-CoA reacts to give a covalent acetyl-enzyme intermediate.


The kinetic mechanism of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from baker's yeast. 1. The effect of independent variation of both acetyl-CoA and acetoacetyl-CoA on the initial velocity at pH8.0 and pH8.9 gives results compatible with a sequential mechanism involving a modified enzyme tentatively identified as an acetyl-enzyme, resulting from the reaction with acetyl-CoA in the first step of a Ping Pong (Cleland, 1963a) reaction. 2. Acetoacetyl-CoA gives marked substrate inhibition that is competitive with acetyl-CoA. This suggests formation of a dead-end complex with the unacetylated enzyme and is in accord with the inhibition pattern given by 3-oxohexanoyl-CoA, an inactive analogue of acetoacetyl-CoA. 3. The inhibition pattern given by products of the reaction is compatible with the above mechanism. CoA gives mixed inhibition with respect to both substrates, whereas dl-3-hydroxy-3-methylglutaryl-CoA competes with acetyl-CoA but gives uncompetitive inhibition with respect to acetoacetyl-CoA. 4. 3-Hydroxy-3-methylglutaryl-CoA analogues lacking the 3-hydroxyl group are found to compete, like 3-hydroxy-3-methylglutaryl-CoA, with acetyl-CoA but have K(i) values ninefold higher, indicating the importance of the 3-hydroxyl group in the interaction. 5. A comparison of inhibition by CoA and desulpho-CoA at pH8.0 and pH8.9 shows that at the higher pH value a kinetically significant reversal of the formation of acetyl-enzyme can occur. 6. Acetyl-CoA homologues do not act as substrates and compete only with acetyl-CoA. A study of the variation of K(i) with acyl-chain length suggests the presence near the active centre of a hydrophobic region. 7. These results are discussed in terms of a kinetic mechanism in which there is only one CoA-binding site the specificity of which is altered by acetylation of the enzyme. 8. The rate of 3-hydroxy-3-methylglutaryl-CoA synthesis in yeast is calculated from the kinetic constants determined for purified 3-hydroxy-3-methylglutaryl-CoA synthase and from estimates of the physiological substrate concentrations. The rate of synthesis of 12nmol of 3-hydroxy-3-methylglutaryl-CoA/min per g wet wt. of yeast is still greater than the rate of utilization in spite of the extremely low (calculated) acetoacetyl-CoA concentration (1.8nm).


The pentose cycle and insulin release in mouse pancreatic islets. 1. Rates of insulin release, glucose utilization (measured as [(3)H]water formation from [5-(3)H]glucose) and glucose oxidation (measured as (14)CO(2) formation from [1-(14)C]- or [6-(14)C]-glucose) were determined in mouse pancreatic islets incubated in vitro, and were used to estimate the rate of oxidation of glucose by the pentose cycle pathway under various conditions. Rates of oxidation of [U-(14)C]ribose and [U-(14)C]xylitol were also measured. 2. Insulin secretion was stimulated fivefold when the medium glucose concentration was raised from 3.3 to 16.7mm in the absence of caffeine; in the presence of caffeine (5mm) a similar increase in glucose concentration evoked a much larger (30-fold) increase in insulin release. Glucose utilization was also increased severalfold as the intracellular glucose concentration was raised over this range, particularly between 5 and 11mm, but the rate of oxidation of glucose via the pentose cycle was not increased. 3. Glucosamine (20mm) inhibited glucose-stimulated insulin release and glucose utilization but not glucose metabolism via the pentose cycle. No evidence was obtained for any selective effect on the metabolism of glucose via the pentose cycle of tolbutamide, glibenclamide, dibutyryl 3':5'-cyclic AMP, glucagon, caffeine, theophylline, ouabain, adrenaline, colchicine, mannoheptulose or iodoacetamide. Phenazine methosulphate (5mum) increased pentose-cycle flux but inhibited glucose-stimulated insulin release. 4. No formation of (14)CO(2) from [U-(14)C]ribose could be detected: [U-(14)C]xylitol gave rise to small amounts of (14)CO(2). Ribose and xylitol had no effect on the rate of oxidation of glucose; ribitol and xylitol had no effect on the rate of glucose utilization. Ribose, ribitol and xylitol did not stimulate insulin release under conditions in which glucose produced a large stimulation. 5. It is concluded that in normal mouse islets glucose metabolism via the pentose cycle does not play a primary role in insulin-secretory responses.


Formation of poly (dA)-poly(dT) by Escherichia coli DNA polymerase in the presence of anthracycline antibiotics.


Escherichia coli alkaline phosphatase. Relaxation spectra of ligand binding. The temperature-jump technique was used to study the binding equilibrium between the Escherichia coli alkaline phosphatase dimer and 2-hydroxy-5-nitrobenzyl phosphonate in 0.1m-tris buffer, pH8.0. Three partially discrete relaxations were observed, two of which could be related to the bimolecular associations of ligand with different conformations of the enzyme and the third to the interconversion of these states. Relaxation spectra were also used to analyse the changes in the mechanism of ligand binding to alkaline phosphatase caused by increase in ionic strength. The relaxation spectrum observed after the addition of P(i) to the equilibrium mixture of phosphonate and enzyme was also studied. Difference spectroscopy indicated that both of these ligands were bound to the alkaline phosphatase dimer at the same time. These results are related to the catalytic mechanism of this enzyme, with particular reference to the role of two identical subunits in a dimeric enzyme that exhibits only one active site functioning in catalysis at any given time.


Studies on transfer RNAs. II. Modification of Escherichia coli formylmethionine transfer RNA.


Identification of circulating micromegakaryocytes in a case of refractory anemia: an electron microscopic-cytochemical study.


Improved viability of previously frozen platelets.


Catecholamines.

Catecholamines.


Altered ratio between axon diameter and myelin sheath thickness in regenerated nerve fibers.


Sinus rate in acute myocardial infarction.


Disseminated breast cancer: evaluation of hormonal therapy utilizing stilbestrol and medrogestone (AY-62022) singly and in combination.


Urinary tract infection: some recent concepts.


Arthur Stoll 1887-1971.

Arthur Stoll 1887-1971.


Primary lymphatic tumors of the mediastinum.


Impairment of red cell transit through the canine lungs following injections of hypertonic fluids.


Trypanosome sterols and their metabolic origins.


Insulin and oral hypoglycaemic agents. II. Clinical and therapeutic aspects.


Suppressive and curative trials in Plasmodium malariae infection with Fansidar.


Antineoplastic and immunosuppressive drugs. I. Biochemical and clinical pharmacological considerations.


Our new president: Henry David Janowitz.


Air environment and animal performance.

Air environment and animal performance.


Current publications in gerontology and geriatrics.


Richard Harrison Shryock 1893-1972.

Richard Harrison Shryock 1893-1972.


Leonardo da Vinci's studies of the alimentary tract.


Kant-Schelling, and the early search for a philosophical 'science' of medicine in Germany.


Genetic approach to DNA replication and its control in Escherichia coli.


A letter from Alexander Humboldt to Charles Darwin.


General features of cycads. Introductory remarks.


Hal Downey's hematological training in Germany, 1910-11.


Averroes' concepts of ocular function--another view.


The American tour of Dr. Spurzheim.

The American tour of Dr. Spurzheim.


Molecular hybridization: a powerful approach to the detection of viral nucleic acid sequences in human cancer.


Historical note on the treatment of amenorrhea with water pepper.


Role of the phagocyte in host-parasite interactions. 38. Metabolic activities of the phagocyte as related to antimicrobial action.


Microperfusion fixation of embryos for ultrastructural studies.


Electron microscopic studies on the structure of rabies virus.


An appraisal of the neurotoxicity of cycad and the etiology of amyotrophic lateral sclerosis on Guam.


Cortical wound healing in the amphibian egg: an electron microscopical study.


Ultrastructure of two species of halobacterium.


Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.


[Physiological aspects of cellular and humoral immunoreactions].


Dr. Jared Kirtland and his warbler.

Dr. Jared Kirtland and his warbler.


Pharmacogenetics.

Pharmacogenetics.


Immunofluorescent method for Au antigen.


Coupled ion and fluid transport in the kidney.


British acupuncture.

British acupuncture.


Limitations of controlled double-blind studies of drugs.


Metabolic properties of 1,2-bisphosphoenolpyruvate.


The diagnosis of love-sickness: experimental psychophysiology without the polygraph.


The transport of cadaver kidneys between renal transplantation units of South Africa.


The true clincal features of postmenopause and oöphorectomy, and their response to oestrogen therapy.


Block allotransplantation of both lungs with pulmonary trunk and left atrium in dogs.


Clinical trial of bromhexine in severe chronic bronchitics during winter.


Summary of recent abstracts. VII. Rickettsial diseases.


Two hundredth anniversary of self-prediction of sudden, exertional cardiac death.


Some new nitroimidazole derivatives. Clinical trials in amebic liver abscess.


Velva Schrire, M.D., F.R.C.P., F.A.C.C. 1917-1972.


Experimental infection of the gibbon (Hylobates lar) with Dirofilaria immitis.


High resolution B-scan ultrasonography of the orbit. 3. Lymphomas of the orbit.


Black orbital bone.

Black orbital bone.


A hook for placement of bridle sutures.

A hook for placement of bridle sutures.


Instinct, appetites and medicine.

Instinct, appetites and medicine.


The British influence on American dentistry.


Application of automation and systems analysis to detection of histidinemia.


A simple view of Parkinsonian tremor. Electrical stimulation of cortex adjacent to the Rolandic fissure in awake man.


Coronal somatosensory unit responses in cats with dorsal column lesions.


Facilitated transport of amino acids through the blood-brain barrier of the dog studied in a single capillary circulation.


The cortico-thalamic projection from the primary somatosensory cortex of the rat.


Epitomes of progress--anesthesiology.

Epitomes of progress--anesthesiology.


List of organizations approved for courses qualifying for category I credits in CMA certification program. The following organizations, societies and institutions have been approved for Category I (formerly Group A) credit towards the California Medical Association's certificate in continuing medical education program. The credit hours are based on the number of hours of the course. Only those courses which are directly related to medical education and applied to patient care are acceptable. Courses put on by approved institutions, in subject matter not directly related to patient care and medical education, are not eligible for Category I credit in the program. This listing is not all-inclusive, as new programs are continuously being accredited, but it is up to date of as August 1, 1972. Physicians should refer to this listing when completing their annual reporting form.


The Société Royale de Médecine and epidemics in the Ancien Régime.


The French revolution, Napoleon, and the nursing profession.


Uterine lipid metabolism--a review of the literature.


New Daniel Drake Correspondence.

New Daniel Drake Correspondence.


The enzymes of the granules of polymorphonuclear leukocytes and their functions.


Utilization of leukocytes for the study of inborn errors of metabolism.


Wound management of Ambroise Paré and Dominique Larrey, great French military surgeons of the 16th and 19th centuries.


A comparative study of the coats of chimaeric mice and those of heterozygotes for X-linked genes.


Morrill Wyman and the aspiration of acute pleural effusions, 1850. A letter from New England.


Sighthill Health Centre.

Sighthill Health Centre.


Genetic locus determining resistance to phage BF23 and colicins E 1 , E 2  and E 3  in Escherichia coli.


Genetic and environmental aspects of udder infections.


Tissue culture and its contribution to biology and medicine.


Evaluation of a cytocentrifuge technique. Effects on quantitative determination of Feulgen-deoxyribonucleic acid and total dry mass of human leukemic cells.


Glycol methacrylate embedding in immunocytochemical methods.


Obfuscation of the activity of antifungal antimicrobics by culture media.


Role of interferon induction in the protective activity of rabies vaccines.


Chemotaxis in acute renal failure.

Chemotaxis in acute renal failure.


Antigenic components in Triatoma infestans haemolymph.


Pharmacokinetics of the treatment of fungal infections.


Banded polytene chromosomes in pericardial cells of Drosophila.


The Glasgow blood pressure clinic.

The Glasgow blood pressure clinic.


Some early records of sex-linked inheritance in fowl.


Infections caused by Serratia marcescens.


Computers in radiotherapy-clinical applications.


Pre-operative radiotherapy.

Pre-operative radiotherapy.


The importance of anaemia in determining prognosis.


Recent advances in radiobiology.

Recent advances in radiobiology.


Blood pressure as a factor in radiotherapy.


Nuclear medicine. Detection of occult metastases and diagnostic role in management of patients with cancer.


Applications of radiobiology to radiotherapy.


Clinical dosimetry.

Clinical dosimetry.


Isodose planning using closed circuit television.


Computers in radiotherapy-physical uses.


Radiosensitivity-simultaneous ultrasonic and ionizing radiation.


Gonadotrophin release factors. In vitro studies of hypothalamic gonadotrophin release factors using bovine tissue.


Biogenic amines and release factors. Studies on the effect of biogenic amines on the hypothalamic production of gonadotrophin release factors in vivo and in vitro.


Hairspray as an inexpensive fixative for Papanicolaou smears.


Regular haemodialysis in chronic renal failure at the Johannesburg General Hospital.


Osteodystrophy in patients on chronic haemodialysis.


Ferritinaemia in haemodialyzed patients and in chronic renal failure.


Glomerulonephritis, nephrotic syndrome and bacterial endocarditis.


The effect of oral rinsing with sodium fluoride on the gingiva of children.


Review of haematemesis and melaena in Thomson Road General Hospital, with special reference to peptic ulcer.


Digital nerve repairs.

Digital nerve repairs.


Advances in facial nerve repair.

Advances in facial nerve repair.


Painful traumatic neuromas.

Painful traumatic neuromas.


Cytotoxic action of pig anti-A erythrocyte antibodies.


Monocyte receptors for immunoglobulin and complement in immunologic deficiency diseases.


In memoriam. Leuman Maurice Waugh (1877-1972).


Dedication and presentation of the first Hayes Martin Lectureship Award.


The social effects of legal abortion.

The social effects of legal abortion.


Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.


Biosynthesis of N-(purin-6-ylcarbamoyl)-L-threonine riboside. Incorporation of L-threonine in vivo into modified nucleoside of transfer ribonucleic acid. l-[U-(14)C]Threonine is incorporated into N-(purin-6-ylcarbamoyl)-l-threonine riboside of rat liver and Escherichia coli tRNA. A pathway is suggested for the biosynthesis of this nucleoside.


Transport of non-electrolytes in yeast.

Transport of non-electrolytes in yeast.


Proton movements coupled to the transport of  -galactosides into escherichia coli.


Properties of Escherichia coli mutants with alterations in glucose uptake.


Inhibition of the utilization of lactose and other carbon sources by 3-deoxy-3-fluoro-D-glucose in Escherichia coli.


Malate permeation as the pacemaker for exogenous malate metabolism in Escherichia coli.


Mechanisms of colicinogeny.

Mechanisms of colicinogeny.


Altered purine permease activity in a purine-analogue-resistant mutant of Saccharomyces cerevisiae.


Specificity of the proline permease of Escherichia coli.


Specificity of the aromatic amino acid permeases of Escherichia coli.


Regulation of the acidic amino acid permease of Aspergillus nidulans.


Non-specific uptake and specific binding of sulfate by Aspergillus nidulans.


The oligosaccharide units of rabbit immunoglobulin G. Asymmetric attachment of C2-oligosaccharide. Two populations of immunoglobulin G (IgG) molecules were isolated from pooled rabbit serum. The first was almost devoid of galactosamine and was obtained in a yield of 7% of the total IgG; the second contained on average a single residue of galactosamine per molecule and was obtained in a yield of 30% of the total IgG. The galactosamine, which is present solely in the C2-oligosaccharide, appeared to be present on one H-chain and not the other in the four-chain structure. Evidence was obtained by the isolation of a glycopeptide linked through a disulphide bridge to a second peptide of the same sequence; the oligosaccharide attached to the first peptide was absent from the complementary peptide. Further evidence was obtained by degradation and analysis of the 5S IgG fragment, which comprises an intact half-molecule coupled through a disulphide bridge to the Fc fragment derived from the opposing half molecule (Goodman, 1965); only the intact H-chain carried the C2-oligosaccharide.


Fissure sealants. Results obtained with two different sealants after one year.


Dental practice in early Singapore (1819-1869).


Sir William Petty: medical education, hospitals, and health care.


Late onset psychosis.

Late onset psychosis.


Ultrasound in cardiac diagnosis.

Ultrasound in cardiac diagnosis.


Immunological activity of transplanted spleens in Xenopus laevis.


The influence of oral metoclopramide on gastric emptying after a fixed water load.


A new endocrine cell type of the human pancreatic islets.


A sign of spina bifida cystica on lateral radiographs of the spine.


Adjuvanticity and delayed-type hypersensitivity by Bacillus Calmette-Guérin (BCG).


A double-labeled frozen section technique for studying distribution of H 3 -norepinephrine.


Inhibition of induction of group A bacteriocins of Serratia marcescens by rifampin.


Behavior of antidinitrophenyl antigen-antibody complexes in hydrochloric acid and guanidine.


Effects of air pollution on asthma: a review.


Variable amounts of DNA related to the size of chloroplasts. IV. Three-dimensional arrangement of DNA in fully differentiated chloroplasts of Beta vulgaris L.


Freeze-fracture replication of rough endoplasmic reticulum of mouse liver cells.


Early repair of myelomeningocele (spina bifida cystica).


A safety-rim modification for the bone dowel impactor in anterior cervical fusions.


A nearly painless method of obtaining Cloward bone plugs.


The surgeons in the Crimea 1854-1856.

The surgeons in the Crimea 1854-1856.


Shock.

Shock.


Unusual bone tumour metastases.

Unusual bone tumour metastases.


Pedicled flaps: an experimental and clinical study.


The history of biomedical education in the Netherlands.


A dual composite medium for the differentiation of the pathogenic enterobacteria and coliform organisms.


Evaluation of a technique for the estimation of serum bactericidal activity against Gram-negative organisms.


Observations on the use of anaerobic jars and the methods of their control.


Enumeration of Treponema pallidum using an electronic counter.


Obituary Professor F.E. Camps.

Obituary Professor F.E. Camps.


Hemodynamic effects of morphine and pentazocine differ in cardiac patients.


The complement system of man. 4.

The complement system of man. 4.


Esophageal hiatal hernia.

Esophageal hiatal hernia.


Meteorism produced by nasotracheal intubation and ventilatory assistance.


Chester Morse Jones 1891-1972.

Chester Morse Jones 1891-1972.


VA study with hepatitis B immune globulin.


A curriculum development project at university level.


Clofibrate for the treatment of occlusive cerebrovascular disease.


Discoveries of late Pleistocene man at Kow Swamp, Australia.


The meaning of "reversed electron flow" and "high energy electron" in biochemistry.


Use of a new detector for x-ray diffraction and kinetics of the ordering of the lipids in E. coli membranes and model systems.


Effects of alkali metal chlorides on activity in rats.


Colour selectivity in motion after-effect.


Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease.


Senescence of an antibody-forming cell clone.


Dominance of a cell clone forming antibody to DNP.


EWstimation of steam-volatile N-nitrosamines in foods at the 1 micro g-kg level.


IgM-IgG1, 2, 3 relationship during pregnancy.


Age, the crystalline lens of the rudd and visual pigments.


The response of human pleura in organ culture to asbestos.


Radiochemicals: variability of quantity in 50 micro Ci packages.


Confusion of mirror images by pigeons and interhemispheric commissures.


Mouse strain identification.

Mouse strain identification.


General theory of chromosome structure and gene activation in eukaryotes.


Monoamine changes in the brain of rats injected with L-5-hydroxytryptophan.


Olfactory bulb removal but not anosmia increases emotionality and mouse killing.


Evidence for ancient tetraploidy and conservation of linkage groups in mammalian chromosomes.


Inhibition of peptide chain elongation.

Inhibition of peptide chain elongation.


Phenylalanine metabolism altered by dietary dieldrin.


Sucrose induction of hepatic hyperplasia in the rat.


Non-random segregation during mammalian oogenesis.


Attack behaviour in mice inhibited by  -9-tetrahydrocannabinol.


Energy substrates and culture of single cell rabbit ova to blastocysts.


Mechanism of mitochondrial mutation in yeast.


Regulatory properties of intergeneric hybrids of aspartate transcarbamylase.


Production and temporary suppression of memory cells during tolerance induction in T cells.


Vernon Douglas Schaffner 1904-1972.

Vernon Douglas Schaffner 1904-1972.


Antibiotic resistance in bacteria.

Antibiotic resistance in bacteria.


Interrelationship of erythropoietic recovery, marrow recovery, colony-forming units, and erythropoiesis-stimulating factors after sublethal x-irradiation.


The genetics of metabolic disorders.

The genetics of metabolic disorders.


Chromosomal abnormalities and mental disorders.


Joseph Weiss (1907-1972).

Joseph Weiss (1907-1972).


Influence of ultrafast repair processes (independent of DNA polymerase I) on the yield of DNA single-strand breaks in Escherichia coli K-12 x-irradiated in the presence of or absence of oxygen.


Ophthalmological Society of New Zealand. Officers and members.


Jules Gonin, his work and his drawings.

Jules Gonin, his work and his drawings.


Howard Vincent Coverdale.

Howard Vincent Coverdale.


Immunodiabetes in the guinea pig. II. Electron microscopy.


Pneumocystis carinii pneumonia. A clinicopathologic study of twenty patients with neoplastic diseases.


Performance of the left ventricle.

Performance of the left ventricle.


Thiomicrospira pelophila, gen. n., sp. n., a new obligately chemolithotrophic colourless sulfur bacterium.


Mapping of the gene for cytosine deaminase on the Escherichia coli chromosome.


A rapid and specific enrichment procedure for Hyphomicrobium spp.


Mapping and fi character determination of R factors of Enterobacter cloacae Df13.


Hippocampal physiology: experiments on regulation of its electrical activity, on the mechanism of seizures, and on a hypothesis of learning.


Localized ECS impedes tast aversion learning.


Biosynthesis of fatty acids and phenols by stationary-phase cultures of Aspergillus fumigatus.


Nitrate repression of xanthine dehydrogenase II in Aspergillus nidulans.


Alcohol and amine catabolism in fungus Aspergillus nidulans.


Control of nucleic acid synthesis in Aspergillus nidulans.


Studies of temperature-sensitive cnx mutants in the fungus Aspergillus nidulans.


Chlorate toxicity in the fungus Aspergillus nidulans.


Amino acid sequences in penicillo-pepsin: evidence for homology with porcine pepsin and chymosin.


Evidence for an acyl intermediate in pepsin-catalysed reactions.


The inhibition of tissue acid proteinases by pepstatin.


Studies on the biosynthesis of cyclic depsipeptides in Serratia marcescens.


Induction of petite mutants in yeast by starvation in glycerol.


Computers in medical diagnosis.

Computers in medical diagnosis.


Early diagnosis of gastric cancer.

Early diagnosis of gastric cancer.


Regional pulmonary function.

Regional pulmonary function.


Allergic contact dermatitis to virginiamycin.


Differential accumulation of lipofuscin pigment in cerebral cortex of rat. A quantitative and morphological study with age after prenatal x-irradiation.


The correlation of individual results in laser microanalysis applied to histological slices.


The presence of N-(purin-6-ylcarbamoyl)threonine in transfer ribonucleic acid species whose codons begin with adenine.


Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy.


Regulation of protein synthesis in chick oviduct. I. Independent regulation of ovalbumin, conalbumin, ovomucoid, and lysozyme induction.


Assembly of the mitochondrial membrane system. 8. Properties of the products of mitochondrial protein synthesis in yeast.


Interaction of colicin Ia with bacterial cells. Direct measurement of Ia-receptor interaction.


The sulfhydryl groups of papaya lysozyme and their relation to biological activity.


COOH-terminal amino acid sequence of histidinol dehydrogenase from a Salmonella typhimurium mutant.


Stringent and relaxed control of phospholipid metabolism in Escherichia coli.


Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. Under restricted culture conditions, the growth and division of Saccharomyces cerevisiae was inhibited by the antimitotic drug Colcemid; in contrast, the related drug colchicine had no effect. The difference in the sensitivity of yeast to these two agents was not dependent on their ability to permeate the cell but rather reflected an inherent difference in the affinity of the two drugs for a cellular-binding site. The binding moiety was characterized by gel filtration as a macromolecule of approximately 110,000 mol wt with an affinity constant for Colcemid of 0.5 x 10(4) liters per mole; in addition, this macromolecule was retained by diethylaminoethyl (DEAE) ion exchangers. On the basis of these properties, the Colcemid-binding substance in S. cerevisiae cells was provisionally identified as microtubule subunits.


Ultrastructure and time course of mitosis in the fungus Fusarium oxysporum. Mitosis in Fusarium oxysporum Schlect. was studied by light and electron microscopy. The average times required for the stages of mitosis, as determined from measurements made on living nuclei, were as follows: prophase, 70 sec; metaphase, 120 sec; anaphase, 13 sec; and telophase, 125 sec, for a total of 5.5 min. New postfixation procedures were developed specifically to preserve the fine-structure of the mitotic apparatus. Electron microscopy of mitotic nuclei revealed a fibrillo-granular, extranuclear Spindle Pole Body (SPB) at each pole of the intranuclear, microtubular spindles. Metaphase chromosomes were attached to spindle microtubules via kinetochores, which were found near the spindle poles at telophase. The still-intact, original nuclear envelope constricted around the incipient daughter nuclei during telophase.


Freeze-fractured myosin filaments.

Freeze-fractured myosin filaments.


Morphometry of the golgi apparatus in developing liver.


Dye-complexed bacterial lipopolysaccharide as a void volume marker for permeation chromatography.


Pathological findings after right lung transplantation in a patient with fibrosing alveolitis. The pathological findings in a patient who died two months after right lung transplantation for fibrosing alveolitis are reported. The cause of death was haemoptysis, due to penetrating ulceration causing a fistula between the surface of the cartilagenous part of the main bronchus of the donor lung and the right upper lobe pulmonary artery. The opening in the donor bronchus was immediately distal to the line of the bronchial anastomosis and through an actively inflamed area. Other parts of the donor bronchus had microscopic changes suggesting ischaemia, emphasizing that inadequacy of blood supply to the donor extrapulmonary bronchus is one of the most serious hazards of lung transplantation. Within the lung, histological features of rejection were mild and there was minimal evidence of infection. Another question raised by this case is whether the donor lung was in the process of developing the original disease, evidence for which was sought electron microscopically but was not proven.


Experiences in the use of commercial antisera for the capsular typing of klebsiella species.


The role of fibrin deposition in diabetic glomerulosclerosis: a light, electron and immunofluorescence microscopy study. The possible role of fibrin deposition in the development of diabetic glomerulosclerosis has been investigated by light, immunofluorescence, and electron microscopy examination of renal tissue obtained by percutaneous biopsy from seven diabetic patients having minimal clinical evidence of renal involvement and at necropsy on nine diabetic patients. Although the biopsy specimens showed only early to moderate diffuse glomerulosclerosis without either nodular or exudative lesions, approximately 70% of glomeruli examined showed specific fluorescence for fibrinogen in a discontinuous linear pattern along the capillary basement membrane and diffusely in the mesangium. Moreover the immunofluorescence findings correlated well with the distribution patterns of material thought to be fibrin both in the light microscopy studies, by virtue of its staining properties, and by electron microscopy, because of periodicity, texture, and electron density. It is suggested that electron-dense granular deposits seen on electron microscopy may represent intermediate compounds in the fibrinogen to fibrin conversion, and that endothelial and mesangial trapping of fibrinogen or other macromolecules may initiate or accelerate mesangial enlargement, nodule formation, and irregularity of the basement membrane.


Virus particles in SJL-J mouse disease.

Virus particles in SJL-J mouse disease.


The seventh pandemic of cholera.

The seventh pandemic of cholera.


Radiography with 160 MeV protons.

Radiography with 160 MeV protons.


Specific IgG mRNA molecules from myeloma cells in heterogeneous nuclear and cytoplasmic RNA containing poly-A.


Dapsone acetylation and the treatment of leprosy.


Natural selection and genetic drift in protein polymorphism.


Evidence for a primary association between immunoblasts and small gut.


Increased shear resistance of human erythrocytes in the presence of glucose.


Selective feeding of Anopheles gambiae according to ABO blood group status.


Carcinogenic nitrosamines formed by drug-nitrite interactions.


Sir Gavin de Beer.

Sir Gavin de Beer.


Mechanism of the antitumour effect of interferon in mice.


Copper and zinc status of ewes and lambs receiving increased dietary concentrations of cadmium.


Female homosexuality.

Female homosexuality.


Involvement of a bacterial factor in morphogenesis of bacteriophage capsid.


Role of the host cell in bacteriophage morphogenesis: effects of a bacterial mutation on T4 head assembly.


In vitro blastogenesis inhibited by Erwinia carotovora L-asparaginase.


LRF and CRF release in subcellular fractions of bovine median eminence.


Human liver replacement. An interim evaluation.


Disulfiramlike effects of trichomonacidal drugs. A review and double-blind study.


A comparative study of three drugs in the treatment of gonorrhoea.


An investigation on the mode of action of sodium azide on the glucose permease of "Escherichia coli" K12.


A new Salmonella species: "S. afula"=6,7:f,g,t:e,n,x,z15.


Immunospecific regression of methylcholanthrene fibrosarcoma using neuraminidase. 3. Synergistic effect of BCG and neuraminidase treated tumor cells.


Early studies of viral hepatitis.

Early studies of viral hepatitis.


Efficacy of preoperative antimicrobial preparation of the bowel.


The course of long incubation (virus B) hepatitis.


Problems of fulminant hepatic failure.

Problems of fulminant hepatic failure.


Pathology of viral hepatitis.

Pathology of viral hepatitis.


Autoimmune aspects of liver disease.

Autoimmune aspects of liver disease.


Hepatitis in transfusion services.

Hepatitis in transfusion services.


Controlled therapeutic trial with the combination rifampicin-isoniazid given for six months to previously untreated patients with pulmonary tuberculosis.


Rifampin in original treatment of pulmonary tuberculosis. A United States Public Health Service cooperative therapy trial.


Regional distribution of feline esophageal blood flow.


Interrelations of hepatitis B antigen and autoantibodies in chronic idiopathic liver disease.


The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach. This is the first case report of the Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach. Plasma gastrin levels were high and gastrin was demonstrated in argyrophil tumour cells by an immunofluorescent technique. Evidence is presented that the tumour arose from the G cells.


The structure and function of gastric mucus.


Smoking and the gastrointestinal tract.

Smoking and the gastrointestinal tract.


Social facilitation of marijuana intoxication: impact of social set and pharmacological activity.


In memoriam. Geoffrey Thomas Ashley, B.Sc., M.D.


Oral nevi: report of case and review of literature.


Border and colour coding in the retina of the frog.


Numerology of development.

Numerology of development.


Chimaeras and cell lineage in development.


A new species of double-stranded RNA from yeast.


Neonatal androgenization and aggression in the male golden hamster.


Susceptibility to cold in newborns of levodopa-treated rats.


Natural regulation of numbers in primitive human populations.


Possible adverse effect of protozoa on effluent purification systems.


Oral history--new technique in medical historiography.


Human alpha-feto-protein.

Human alpha-feto-protein.


Potentiation between pentagastrin and bethanechol chloride in stimulation of gastric secretion from isolated ex vivo canine stomach perfused with homologous blood.


Aging: noncycling cells an explanation.

Aging: noncycling cells an explanation.


Total Leydig cell volume and its estimation in dogs and in models of testis.


Clinical transplantation of the heart.

Clinical transplantation of the heart.


The fate of patients after renal transplantation, graft rejection, and retransplantation.


Effect of rabbit ALG on cadaver kidney transplant survival.


Tolerance, enhancement and prolonged survival of organ trnasplants.


Homologous serum hepatitis and the dental treatment of renal dialysis and kidney transplant patients.


Induction of immunological tolerance to allogeneic tissues in the canine species.


A post crown technique using a nickel-cobalt-chromium post.


Professor Francis Edward Camps.

Professor Francis Edward Camps.


Peer evaluation: its potential usefulness in medical education.


Simulation of the diagnostic process: a further comparison.


Malaria in the U.K.

Malaria in the U.K.


Bright's disease today: the pathogenesis and treatment of glomerulonephritis--I. Since Bright's day the study of glomerulonephritis has largely consisted in the observation of the clinical, biochemical, and morphological characteristics of patients. Linked to this has been the attempt to name and classify these data in a fashion which improved prediction of outcome and response to treatment. This has proved difficult, since there is no absolute correspondence between clinical syndromes and the morphological findings in the kidney. The histological data have, however, allowed good prediction of prognosis and response.We now have enough information from experimental models of nephritis and from clinical observation to outline the pathogenesis of glomerulonephritis. Immune mechanisms are certainly concerned in some patients, the role of chronic soluble complex deposition in the kidney being particulary important. Non-immunological origins and mediation of injury, however, are at least as important. Injury to the glomerulus is mediated through the interaction of complement and coagulation mechanisms, leading through the release of soluble factors to inflammation. Repair is probably central in producing irreversible glomerular damage.Treatment can now be directed towards the events concerned in the pathogenesis of nephritis, the most accessible at the moment being the immediate mediators of injury. At a more fundamental level better identification in individual patients of the events leading to the injury is needed, such as the isolation, avoidance, or elimination of the antigens involved in chronic soluble complex disease. Laboratory techniques to begin these investigations in man are now available and need to be applied more widely in the clinical field to patients with glomerulonephritis.


Louis H. Nahum, M.D. 1892-1972.

Louis H. Nahum, M.D. 1892-1972.


Influence of cortical plasma transit-time on p-aminohippurate extraction during induced renal vasodilatation in anaesthetized dogs.


Current status of cardiac pacing.

Current status of cardiac pacing.


An anterior component of the accessory optic system of the cat, with evidence for the absence of reticuloretinal fibers.


Hazards of irradiated liquid nitrogen--a brief bibliography.


Comparison of perfusates for in mortuo renal perfusion.


Doctor Compton resigns.

Doctor Compton resigns.


Dentistry's contribution to political history.


Marking of dentures.

Marking of dentures.


Leroy d'Etoilles (1798-1860).

Leroy d'Etoilles (1798-1860).


Hypermetabolic state following renal allotransplantation.


A method for in situ embedding of cultured cells grown on plastic surfaces.


Cementation of dental implants: rationale and preliminary observations.


Tissue adhesives in dentistry. A review.


Relationship of somatic cells in quarter milk to type of bacteria and production.


Evaluation of a direct method for measuring absorption from the gut.


Measurement of portal blood flow in calves by dye-dilution.


The effects of anti-macrophage serum on the antibody response.


Progressive retinal atrophy. A review of the genetics and an appraisal of the eradication scheme.


Lysolecithin-induced fusion of fibroblasts.


Irreversible liver damage after azathioprine.


Colestipol and cholestyramine resin. Comparative effects in familial type II hyperlipoproteinemia.


Joseph Eldridge Markee: scientist, medical educator, and biocommunicator.


'N.K.H': prioneer and chronicler of medical photography.


Excitable membranes.

Excitable membranes.


Protein breakdown inhibited by insulin to improve heart culture.


Evidence for a sex-linked difference in aspirin metabolism.


Teratogenicity of hycanthone in mice.

Teratogenicity of hycanthone in mice.


Transferable chloramphenicol resistance in Salmonella typhi.


Stability of X chromosomal inactivation in human somatic cells.


Total breakdown of ribosomal and transfer RNA in a mutant of Escherichia coli.


Initial nucleotide frequencies of bacterial RNA synthesized during amino-acid starvation or changes of carbon source.


Enzymatic synthesis of deoxyribo-oligonucleotides of defined sequence.


Water-soluble and lipid-free fraction from BCG with adjuvant and antitumour activity.


How dentists view Medicaid in Massachusetts.


Topical anesthetic effectiveness. An old and new product evaluated.


Primary peritonitis.

Primary peritonitis.


A new method for preparation of experimental coarctation of the aorta.


Experimental studies on aspiration of contents of obstructed intestine.


Renal preservation by hypothermic storage plus pulsatile perfusion.


Tetrafluoroethylene felt used for buttressing sutures in renal operations.


An early example of the use of surgical techniques in solving a physiologic problem (Francois Magendie).


Lymphedema.

Lymphedema.


A serological, clinical and morphological study of eight kidney grafts in three patients.


Mastitis as a production disease.

Mastitis as a production disease.


Pharmacology and toxicology of alpha chloralose: a review.


The structure of the helminth cuticle.

The structure of the helminth cuticle.


Respiratory function after lung homotransplantation with a ten-month survival in man.


Alveolar manifestations of rejection: an important cause of the poor results with human lung transplantation.


Ventilatory and circulatory adjustments after transplantation of the lung.


Auxiliary liver transplantation: a successful model without portal blood or portacaval shunt.


The glove starch peritonitis syndrome.

The glove starch peritonitis syndrome.


The starch-peritoneal reaction: an experimental study.


Coagulation changes of septic shock in the sub-human primate and their relationship to hemodynamic changes.


The biology of bile acids.

The biology of bile acids.


Hepatic synthesis of bile acids. Biochemical steps and mechanisms of rate control.


Micelle formation by bile salts. Physical-chemical and thermodynamic considerations.


The role of bile acids in the overall regulation of steroid metabolism.


Secretion of bile acids by the liver and their role in the formation of hepatic bile.


Modification of bile acids by intestinal bacteria.


The roles of bile acids during the process of normal fat and cholesterol absorption.


Treatment of hypercholesterolemia by interference with bile acid metabolism.


Tritium labeling of proteins with  3 H-chloroform.


A ribose binding protein of Salmonella typhimurium.


Inhibition of the chloramphenicol binding to ribosomes by the sparsomycin-induced binding of aminoacyl-tRNA to ribosomes.


Mannan as a major component of the bud scars of Saccharomyces cerevisiae.


Prevention by cycloheximide of petite mutation in yeast.


Lack of polyadenylic acid sequences in the messenger RNA of E. coli.


Inosine and guanine phosphoribosyltransferase in Escherichia coli.


Augmentation by  -aspartyl phosphate of threonine control of the dehydrogenase activity of the aspartokinase-homoserine dehydrogenase complex.


Obligatory requirement of intramitochondrial ATP for normal functioning of the eucaryotic cell.


Evolution of transfer RNA molecules as a repetitive process.


Urea carboxylase and allophanate hydrolase: two components of a multienzyme complex in Saccharomyces cerevisiae.


Segregation of membrane components using isoelectric focusing in polyacrylamide gels.


Crystallization and molecular packing of E. coli arginine transfer RNA.


Ultraviolet therapy of psoriasis: a critical study.


Griseofulvin therapy in lichen planus. A double-blind controlled trial.


Recent progress in the formulation of vehicles for topical applications.


Malignant atrophic papulosis (Degos' syndrome).


Experimental organ preservation.

Experimental organ preservation.


The effect of ischaemic injury on kidneys preserved for 24 hours before transplantation.


Azathioprine in the treatment of Crohn's disease.


Immunosuppression and malignancy.

Immunosuppression and malignancy.


Rosette inhibition test in management of transplantations.


Cataracts after renal transplantation.

Cataracts after renal transplantation.


Bronchodilator therapy: comparison of acute response to three methods of administration.


Serial bronchography following pulmonary autotransplantation.


Isolated lobular pulmonary artery atresia with systemic collaterals in tetralogy of Fallot.


The use of autologous fibula for a prop graft in depressed lateral tibial plateau fractures.


Osteoinduction and osteogenesis in implants of allogeneic bone matrix. Influence of somatotropin, thyrotropin, and cortisone.


Homotransplantation of a half or whole joint.


Massive osteo and osteo-articular bone grafts. Technic and results of 62 cases.


The current status of bone and joint transplants.


Postoperative infection after total hip replacement with special reference to air contamination in the operating room.


Immunological responses to bone.

Immunological responses to bone.


Femoral shaft fractures and the above-knee amputee: use of the compression plate. A report of three cases.


Bilateral carpal lunate ganglia.

Bilateral carpal lunate ganglia.


Human autologous cortical bone transplants.


Bone grafts and implants. Editorial comment.


Homografts of bone.

Homografts of bone.


Vascularization of bone grafts and implants.


Clinical implications of cell function in bone grafting.


The classic. Transplantation of a portion of the tibia into the spine for Pott's disease. A preliminary report. Jama, 57: 885, 1911.


Bridging of bone defects by massive bone grafts in tumorous conditions and in osteomyelitis.


Muscle pedicle bone grafting of long bones by osteoperiosteal decortication.


A clinical study of the biomechanical behavior of massive bone transplants used to reconstruct large bone defects.


Current experience with organ transplantation.


The chitin-glucan complex in Saccharomyces cerevisiae. I. IR and x-ray observations.


Joining of lambda bacteriophage DNA molecules in vitro using the gene product of the lambda int phage.


Energy requirement for amino acid uptake in Saccharomyces cerevisiae.


Sex-determined chemotaxis in Salmonella typhimurium LT2.


Uptake of amino acids by actidione-treated yeast cells. IV. Interaction with sugars.


The formation of  -galactosidase in soil.


Continuous cultivation of microorganisms. A review.


Androgen production and metabolism in normal and virilized women.


Mutation to prototrophy in Escherichia coli K-12: effect of broth on UV-induced mutation in strain AB1157 and four excision-deficient mutants.


Ultraviolet mutagenesis in repair-deficient derivatives of Escherichia coli B-r: uvrA recB and uvrA recC strains.


Medical management of primary hypertension (first of three parts).


The blue baby--circulation or ventilation or both?


Renal failure--"we dance in circles".

Renal failure--"we dance in circles".


Structural genes of ATP-dependent deoxyribonuclease of Escherichia coli.


Cistron specific translation control protein in Escherichia coli.


Host subunit of Q  replicase is translation control factor i.


Radiosensitization of hypoxic cells in vitro: a water-soluble derivative of paranitroacetophenone.


Partial nucleotide sequence of 16S ribosomal RNA from E. coli.


Lactoferrin--a bacteriostatic protein in human milk.


Fetal growth and maternal nutrition.

Fetal growth and maternal nutrition. Very few studies have been done on the chemical development of fetuses in utero; such knowledge may prove useful in determining nutritional requirements of pregnant women.  Apte and Iyengar studied the composition of a series of fetuses from mothers belonging to low socoioeconomic groups in Hydrabad, India, and compared the results with those obtained from other studies.  Of 41 infants analyzed, 29 were stillborn while the other 12 died within 12 hours of birth.  Livers from dead fetuses were removed and the remainder dried in an air oven, after which the fetuses were grounded for chemical analysis of total nitrogen, fat, calcium and phosphorus, magnesium and iron contents (results of the chemical analysis were presented in a separate paper by the authors).  Comparison of fetal body weights with data used by Hytten and Leitch, assuming that gestational ages of fetuses were correct, suggested that most of the infants were "small for date".  Comparison with British data showed that up until about 26 to 28 weeks of gestation, the fetuses had a similar composition; after that age, the Indian series exhibited fetal growth retardation, and a considerably lower protein and fat content.  The findings suggested that the fetuses of the poorly nourished mothers (mean gain weight during pregnancy was only 6 kg.; almost half of them did not gain weight at all after the 32nd week of pregnancy) had suffered fetal growth retardation; not only were the fetuses smaller, their chemical composition had also been altered.  The need for prenatial nutrition of mothers of low socioeconomic background was emphasized.


Oral contraceptive agents and vitamins.

Oral contraceptive agents and vitamins.


Control of enzyme levels in vitamin deficiency.


Iron deficiency anemia and physical performance.


Biosynthesis of pyridoxol in Escherichia coli.


Dietary control of microsomal stearyl--CoA desaturation in rat liver.


Colonial medicine. Its roots and background.


Spinal dysraphism.

Spinal dysraphism.


Myelomeningocele.

Myelomeningocele.


Cardiac surgery in early infancy.

Cardiac surgery in early infancy.


Ibuprofen in rheumatic conditions.

Ibuprofen in rheumatic conditions.


Artificial ventilation, prolonged endotracheal intubation and tracheostomy in paediatric surgery.


The illnesses of Lewis Carroll.

The illnesses of Lewis Carroll.


Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes. Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.


Summary of recent abstracts. 8. Leprosy.


Summary of recent abstracts. IX. Helminthiasis. Trematode infections.


Subclinical malabsorption in developing countries.


Microflora of the gastrointestinal tract in tropical enteritis: a current appraisal.


Effect of neonatal folic acid deprivation on later growth and susceptibility to Shigella infection in the guinea pig.


The use of povidone-iodine for treatment of fungi in rabbit eyes.


A new ocular insert device for continuous constant-rate delivery of medication to the eye.


Problems in eyelid reconstruction.

Problems in eyelid reconstruction.


The role of babbling in the child's acquisition of language.


The case of linguistics: a prognosis.

The case of linguistics: a prognosis.


Modern linguistics and aphasia.

Modern linguistics and aphasia.


Looking for help for linguistics.

Looking for help for linguistics.


Origin of endothelium in human renal allografts. Sex chromatin counts performed on the endothelial cells of 40 human kidneys transplanted to recipients of the opposite sex showed that the donor endothelium had persisted except in three poorly functioning and severely damaged grafts. In these a high proportion of the endothelial cells in peritubular capillaries and veins were derived from the host. Endothelial repopulation of organ allografts probably occurs only after severe tissue injury, and it cannot explain the phenomenon of graft adaptation. Repopulated endothelium may be derived from circulating cells.


Cataracts after renal transplantation.

Cataracts after renal transplantation.


Effects of dietary fibre.

Effects of dietary fibre.


Cardiovascular disease in the tropics. IV. Coronary heart disease.


Kidney preservation by surface cooling: analysis of 130 transplants. An analysis of 130 consecutive cadaveric renal transplants has shown the effectiveness of simple surface cooling of organs before transplantation. The primary graft failure rate was 10%, and kidneys could be stored for periods of up to 12 hours including warm ischaemia times of 150 minutes. Forty-eight patients received haemodialysis before transplantation and 78 patients received peritoneal dialysis. There were significant differences in the incidence of tubular necrosis in the two groups: these may have been linked to the differences in fluid and osmotic load presented to the transplants.


Liver preservation by single passage hypothermic "squirt" perfusion. A single passage, hypothermic, intermittent squirt perfusion of the pig's liver is described which has allowed preservation of porcine livers for up to 17 hours. After preservation, orthotopically allografted livers can maintain recipient animals in good health. If this technique can be applied to clinical liver transplantation it should be possible to move livers from one hospital to another in the same way that kidneys are transported. This should increase the availability of donor livers for transplantation and avoid the serious disadvantages of moving the sick recipient just before the operation to the hospital where the donor has died.


Treatment of early breast cancer.

Treatment of early breast cancer.


Brucellosis in Uganda. I. The epizootological and epidemiological situation. A historical review.


The membership of the Omaha Dental Assistants' Society 1972-73.


Complications of adolescent pregnancy. Survey of the literature on fetal outcome in adolescence.


Meningitis due to Escherichia coli 0126:B16. Report of a fatal case in a girl aged 14.


Estasblishing physiologic postpalatal seal with elastic material.


Effect of lipid status on cytoplasmic and mitochondrial protein synthesis in anaerobic cultures of Saccharomyces cerevisiae.


Numerical study of 60 strains of Serratia.


The effect of triazole on cysteine biosynthesis in Salmonella typhimurium.


Polyene resistance and the isolation of sterol mutants in Saccharomyces cerevisiae.


Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae.


The influence on numerical taxonomic similarities of errors in microbiological tests.


Regulation of yeast acid phosphatase by orthophosphate and phenylmercuric acetate.


Studies of the binding of Escherichia coli RNA polymerase to DNA. I. The role of sigma subunit in site selection.


Studies of the binding of Escherichia coli RNA polymerase to DNA. II. The kinetics of the binding reaction.


Studies of the binding of Escherichia coli RNA polymerase to DNA. 3. Tight binding of RNA polymerase holoenzyme to single-strand breaks in T7 DNA.


Studies of the binding of Escherichia coli RNA polymerase to DNA. V. T7 RNA chain initiation by enzyme-DNA complexes.


Studies of the binding of Escherichia coli RNA polymerase to DNA. IV. The effect of rifampicin on binding and on RNA chain initiation.


Denaturation map of bacteriophage T7 DNA and direction of DNA transcription.


Transcription of bacteriophage T4 DNA by Escherichia coli RNA polymerase in vitro: identification of some immediate-early and delayed-early genes.


Ultraviolet-induced repair synthesis in the duplicated and non-duplicated regions of the Escherichia coli chromosome.


In memoriam. W.W. Cort--master hookworm investigator.


Ultrastructure of embryonic envelopes and their differentiation in Hymenolepis diminuta (Cestoda).


Comparison of pepsin and alkali digestion methods for determining n-valeric acid in trichinous swine muscle.


Penetration of cultured cells by Eimeria meleagrimitis and E. tenella sporozoites.


The sailor's stomach.

The sailor's stomach.


Non-narcotic analgesics--their use and abuse.


Quantifying the need for cardiac support in human shock by a functional model of cardiopulmonary vascular dynamics: with special reference to myocardial infarction.


Renal failure: the agony and the ecstasy.


Experience in clinical lung transplantation.


Treatment of aberrant carotid arteries in the middle ear: a report of two cases.


[Retention and stability of denture vibration].


Distinguished biochemical discoveries and biochemists on the Berkeley Campus (1920-1970).


Experimental studies for the evaluation of bactericidal plastic surgical sutures.


New method of preparation of animal heart valves for clinical use.


Intratesticular ovarian grafts and the problem of tumorigenic hypophysial imbalances due to autolytic compounds.


Advances in obstetrics and gynaecology.

Advances in obstetrics and gynaecology.


Advances in medicine.

Advances in medicine.


Advances in gastroenterology.

Advances in gastroenterology.


Advances in the treatment of blood disorders.


Advances in geriatrics.

Advances in geriatrics.


Advances in the treatment of peripheral vascular disease.


Advances in the surgery of the rectum and colon.


Advances in the treatment of drug addiction.


Advances in the care of the injured.

Advances in the care of the injured.


Advances in dentistry.

Advances in dentistry.


'Obscurely wise and coarsely kind'. Robert Levett c. 1705-1782.


Renal transplantation in rabbits. 8. The relationship between lymphocytotoxic antibodies, renal IgG deposits and the renal allograft reaction in rabbits sensitized by multiple skin grafts.


The heterophile reaction between anti-mouse thymocyte sera and sheep erythrocytes.


Elimination of non-viable cells by DNase treatment prior to lymphocytotoxicity test.


Computer selection of donor-recipient pairs.


Acceleration of the barium meal through the small intestine by the c-terminal octapeptide of cholecystokinin.


The abdominal aortogram: an historic perspective.


Pulmonary cryptococcosis. A case due to Cryptococcus albidus.


A challenging concept: a lower denture which protects the alveolar bone of the lower jaw.


Immunology of bovine heart valves. II. Reaction with connective tissue components.


Host-controlled segregation of R factor.


The kinetics of endotoxin production in cultures of Shigella sonnei.


The effect of cold on platelets. II. Platelet function after short-term storage at cold temperatures.


Glucosteroids in immunologically specific and nonspecific inflammatory processes.


Regional cerebral blood flow. Response to carbon dioxide inhalation in cerebrovascular disease.


Inhibition of the generalized Shwartzman reaction by hypofibrinogenemia.


Fifth progress report on the British Institute of Radiology fractionation trial of 3F-week or 5F-week treatment of larynx and pharynx.


The haemopoietic activity of the mouse spleen, at different ages, and its response to external and internal irradiation.


Physiological adaptations: hypertrophies and superfunctions.


Systemic mycoses in children. I.

Systemic mycoses in children. I.


The pseudocholinesterase variants. A family segregating for two homozygotes with the fluoride resistant gene.


Familial male pseudohermaphroditism.

Familial male pseudohermaphroditism.