The chromosomal nature of lesions responsible for lethal sectoring in yeast.


Association of children's diseases in families from record linkage data.


Psychological adverse effects of cannabis smoking: a tentative classification. This paper stresses the need for an early definition and description of the "deviant" cannabis smoker in North America. Attention is called to the fact that on this continent heavy smokers have not yet been separated as "problem" users from other smokers.A comprehensive review of possible psychological adverse effects of the drug is made. The following classification is suggested: a) Severe intoxications, b) Pathological intoxications, c) Acute cannabis psychoses, d) Subacute and chronic cannabis psychoses and e) Residual conditions.


The number of catalytically essential carboxyl groups in pepsin. Modification of the enzyme by trimethyloxonium fluoroborate.


Immunoglobulin receptors on B lymphocytes: shifts in immunoglobulin class during immune responses.


Clinical use of psychotherapeutic drugs. II. Antidepressant and antianxiety drugs and special problems in the use of psychotherapeutic drugs.


Lower extremity amputation in hemophilia. Case report and review of surgical principles.


Management of the young child with bilateral anomalous and functionless lower extremities.


In memoriam. Sir Reginald Watson-Jones.

In memoriam. Sir Reginald Watson-Jones.


Tuberculosis of the spine in children. Operative findings and results in one hundred consecutive patients treated by removal of the lesion and anterior grafting.


The use of methylmethacrylate as an adjunct in the internal fixation of malignant neoplastic fractures.


Iliopsoas muscle transfer in the treatment of myelomeningocele patients with paralytic hip deformities.


Evaluation of renal flush-out.

Evaluation of renal flush-out.


Leo Mayer 1884-1972.

Leo Mayer 1884-1972.


Presidential address.

Presidential address.


Immunological maturation. Preferential proliferation of high-affinity precursor cells.


Direct demonstration of theta-positive antigen-binding cells, with antigen-induced movement of thymus-dependent cell receptors. Anti-thetaAKR antibody conjugated to fluorescein has been used in direct immunofluorescence tests to identify spleen theta(+) (T) sheep erythrocyte rosette-forming cells in AKR mice. Specificity studies involving A and cogenic A/thetaAKR mice clearly demonstrated that the cell surface fluorescence and cytotoxicity produced by the antiserum is directed solely toward the thetaAKR alloantigen. Approximately (3/8) of rosette-forming and non-rosette-forming spleen cells were found to be theta(+). The tendency for T cells to bind less antigen and the tendency for antigen-binding T cells to bear less theta than other spleen T cells, first suggested by other studies involving rosette-elimination by anti-thetaC3H plus complement, were confirmed by direct immunofluorescence. All AKR rosettes are specifically inhibitable by anti-immunoglobulin, including T rosettes. Antigen-induced redistribution of T cell receptors, analogous to that previously described for B cell receptors (16), occurs as readily in theta(+)RFC as in theta(-) RFC, without altering the symmetrical ring distribution of thetaAKR antigen.


Immunofluorescent studies of human spermatozoa.


Ovine luteinizing hormone release induced by a synthetic gonadotrophin-releasing factor.


The rôle of a gonadotrophin-releasing factor (Gn-RH) in the oestrogen-induced release of FSH and LH in the ewe.


The release of luteinizing hormone by oestradiol-17  and a synthetic gonadotrophin-releasing factor in ewes affected with clover disease.


Mitochondrial membranes and mutagnesis by ethidium bromide.


The kinetics of colicin E3 induced fragmentation of Escherichia coli 16S ribosomal RNA in vivo.


Recombination in yeast mitochondrial DNA.


Study of envelope proteins in E. coli cet and recA mutants by SDS acrylamide gel electrophoresis.


Guide to drug usage in adult patients with impaired renal function. A supplement.


Disease and history.

Disease and history.


Chemical dependency. An overview.

Chemical dependency. An overview.


A new product for management of dermatoses.


A new method for testing genetically active metabolites. Urinary assay with cyclophosphamide (endoxan, cytoxan) and Saccharomyces cerevisiae.


Enrichment for temperature-sensitive and auxotrophic mutants in Saccharomyces cerevisiae by tritium suicide.


The clinical use of diuretics. 2.

The clinical use of diuretics. 2.


Abnormal pancreatic alpha-cell function in bacterial infections.


Digitalis glycosides. I.

Digitalis glycosides. I.


Color vision.

Color vision.


New look at HL-A typing--importance of the four antigens.


Dr. Jerome L. Reeves on pellagra in North Carolina Appalachia. An interview.


Recurrent urinary infection.

Recurrent urinary infection.


Candida and candidiasis. 1. Cultural conditions, epidemiology and pathogenesis.


Immunosuppression--agents, procedures, speculations and prognosis.


Renal blood flow in hypertension and in renal disease.


Prostaglandin mediated luteolytic effect of an intrauterine device in sheep.


Biological evidence for the direct stimulating effect of PGF2 alpha on the release of pituitary luteolytic agent(s) of pseudopregnant rats.


Cellular localiation of prostaglandin A2 in the rat kidney.


The hippocampus and motivation.

The hippocampus and motivation.


Electron microscopical observations on sheep umbilical vessels.


Obituary notice. Richard Charles Oldfield (1909-1972).


Determinants of sexual behaviour in the assessment of sexual deviations.


Concepts in mechanical assisted ventilation.


Medicare. B. Drugs and biologicals.

Medicare. B. Drugs and biologicals.


Serological studies on cattle experimentally infected with African trypanosomes. Preliminary communication.


Variations of HL-A antigens in populations (a survey).


Course of alloxan diabetes in duct-ligated rats. A functional and morphological study.


Perirenal fibrosis as a cause of uremia and hypertension in human transplanted kidneys.


Alloxan diabetes in duct-ligated rats. Light and electron microscopic findings.


Reticulum cell neoplasms in normal and benzene treated hairless mice.


Reversible inactivation and reactivation of thymidylate synthetase.


Some roles of polyamines in microbial physiology.


Immunologic diagnosis of schistosomiasis. 3. The effects of nutritional status and infection intensity on intradermal test results in St. Lucian children.


Immunologic diagnosis of schistosomiasis. I. A controlled study of intradermal (immediate and delayed) and serologic tests in St. Lucians infected with Schistosoma mansoni and in uninfected St. Vincentians.


Some aspects of the regulation of fuel supply in omnivorous animals.


Hemoglobin A 2  and malaria.

Hemoglobin A 2  and malaria.


Control of deoxyribonucleotide synthesis in vitro and in vivo.


Relapsing idiopathic polyneuritis during pregnancy. Immunological aspects and literature review.


Mevalonate synthesis in the mitochondria of yeast.


The possible occurrence in vivo of the autostimulating factor for lymphocytes.


Limbal incision with conjunctival continuous key-pattern suture in squint surgery.


Dissection technique in lamellar keratoplasty.


Criteria for the classification of juvenile rheumatoid arthritis.


Porphyria and George 3rd.

Porphyria and George 3rd.


Organization of clinical trial on national scale: management of early cancer of the breast. From a study of the organization of a national clinical trial on the management of early cancer of the breast in women there appear to be overwhelming advantages in studying large numbers of patients. To this end centres abroad have been encouraged to join. All the evidence at present suggests that it is feasible to organize a study on this scale, that the documentation and follow-up are accurate, and that the enthusiasm of the participants can be successfully fostered and maintained.


Induction of labour by simultaneous intravenous administration of prostaglandin E 2  and oxytocin. In a group of 20 matched primigravid patients labour was induced by forewater amniotomy followed by intravenous oxytocin (Syntocinon) administered in escalating doses. Ten of these patients, in a double-blind trial, also received prostaglandin E(2) infused simultaneously with the oxytocin. In the combined prostaglandin-oxytocin group there was a noticeable reduction in the dosage of oxytocin required to produce effective uterine action, and the duration of labour was also reduced. No side effects were observed.


Canada's foremost pathologist of the nineteenth century--William Osler.


Some aspects of equine obstetrics.

Some aspects of equine obstetrics.


Human "barkers".

Human "barkers".


Aortic atherosclerosis in exotic avians.


Coronary artery lesions in Atlantic salmon (Salmo salar).


Microvillous anomalies induced by various conditions of stress in the small intestine of the rat.


Effect of pregnenolone-16 -carbonitrile on the hepatic ultrastructure, glycogen content and ethylmorphine n-demethylase activity in pregnant, fetal, and newborn rats.


Structure of a hypothalamic peptide possessing gonadotropin-releasing activity.


Polytransductant formation in Escherichia coli lysogens.


Methionine transport in wild-type and transport-defective mutants of Salmonella typhimurium.


Metabolic activity of purified suspensions of Mycobacterium lepraemurium.


Kinetics of differentiation of conidiophores and conidia by colonies of Aspergillus nidulans.


Sterols from polyene-resistant mutants of Candida albicans.


Further demonstration of bacterial lipids in Mycobacterium bovis harvested from infected mouse lungs.


Simple and expedient methods of differentiation among Bacteroides, Sphaerophorus and Fusobacterium.


Nephritogenic glycoprotein. II. Experimental production of membranous glomerulonephritis in rats by a single injection of homologous renal glycopeptide.


Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. IV. Macrophage turnover, lysosomal enzymes, and division in healing lesions.


The pathogenesis of rat virus infections in the newborn hamster.


Some P.L. 92-603 provisions may rekindle interest in Medicare participation.


What is nursing?

What is nursing?


The patient's point of view.

The patient's point of view.


Arterial distribution of the parotid duct in cat by plastic injection method.


Synchronization of tumor cell proliferation and the timing of cytostatic drugs.


Immunological evidences for proliferation and migration of lymphocytes induced by administration of potent antitumor phosphomucolipid in tumor-bearing mice.


Reuben Jacobson.

Reuben Jacobson.


Albert Marais.

Albert Marais.


The management of head injuries. A review.


Professor J.F. Brock.

Professor J.F. Brock.


Imported malaria in Cape Town: a life-threatening hazard. Experience at Groote Schuur Hospital 1965-1972.


In memoriam: Rt Hon. Lord Rosenheim.

In memoriam: Rt Hon. Lord Rosenheim.


Some recent advances in coagulation--1972.


In memoriam: James Barnetson.

In memoriam: James Barnetson.


Renal mechanisms for regulation of uric acid excretion, with special reference to normal and gouty man.


Neuropathic joints.

Neuropathic joints.


Experimental models of degenerative joint disease.


Joint and bone disorders and hypoparathyroidism in hemochromatosis.


Primary melanoma in the oral mucous membrane.


Transplantation of bone treated with ethylenediamine into tooth sockets in immediate denture patients.


IBR abortion and its control.

IBR abortion and its control.


Folk medicine and some bypassed therapeutic measures of another day.


Isoelectric spectra of native and base denatured crystallized swine pepsin.


Location of O-acetyl groups in the Shigella flexneri types 3c and 4b lipopolysaccharides.


Circulatory changes in the anhepatic phase of experimental liver transplantation.


The fate of muscle and cotton wrapped about intracranial carotid arteries and aneurysms. A laboratory and clinico-pathological study.


Renal allograft rejection presenting with gross hematuria: case report.


Laboratory suggestion: cascade system for space-saving perfusion-fixation of lungs.


In memoriam. Cornelius J. Burns, M.D., 1919-1971.


In memoriam. George K. Higgins, M.D., Ph.D., 1904-1972.


In memoriam. Ernest S. Olson, M.D., 1901-1972.


In memoriam. Max Maurice Strumia, M.D., 1896-1972.


Isolation of Candida parapsilosis: report of two cases.


Anomalous serum bactericidal activity.

Anomalous serum bactericidal activity.


Prophylactic cephaloridine in the prevention of postoperative pelvic infections in premenopausal women undergoing vaginal hysterectomy.


Lability of human decidual cells. In vitro effects of autolysis and osmotic stress.


The psychological evaluation of patients for a kidney transplant and hemodialysis program.


Induction of ovulation in rabbits by synthetic luteinizing hormone-releasing hormone.


The effect of financing on psychiatric care.


Peer review: prospects and problems.

Peer review: prospects and problems.


Bernard Glueck, Sr. 1884-1972.

Bernard Glueck, Sr. 1884-1972.


Occlusion of the great veins in the Behcet syndrome.


The lymphocyte in immunobiology.

The lymphocyte in immunobiology.


Testicular complications following renal transplantation.


Auxiliary liver transplantation in the dog as temporary support in acute fulminating hepatic necrosis.


Prophylactic efficacy of lithium carbonate in manic-depressive illness. Report of the Veterans Administration and National Institute of Mental Health collaborative study group.


Niacin in the long-term treatment of schizophrenia.


How real is the realistic ego in psychotherapy? A one-sided review.


9 -Tetrahydrocannabinol in depressed patients.


Territorial quarantine.

Territorial quarantine.


Visual-vestibular interaction and motion perception.


Partial resolution of oxidative phosphorylation in yeast mitochondria.


Cardiology in the days of Laennec. The story of auscultation of the heart.


Venereology--a backward look.

Venereology--a backward look.


Dialysis and transplantation: the national picutre over the next five years.


Dark-recovery in a petite mutant of Saccharomyces cerevisiae irradiated with ultraviolet light.


The fate of polymorphonuclear neutrophils and mononuclear cells during allograft rejection in the urodele Pleurodeles waltlii Michah.


DNA repair synthesis after x-irradiation in E. coli.


Pathophysiology of rheumatoid arthritis.


A generalized homology correlation for various hormones and proteins.


The chromosomal integration of a  -lactamase gene derived from the P-type R-factor RP1 in Escherichia coli.


The role and character of immunoglobulins in rheumatoid inflammation.


Analysis of the resistance mediated by several R-factors to tetracycline and minocycline.


Emotional factors in coronary disease.

Emotional factors in coronary disease.


Transport and oxidation of glycine in mammalian pancreatic islets with reference to the mechanism of amino acid-induced insulin release.


Fine structure of Methanobacterium thermoautotrophicum: effect of growth temperature on morphology and ultrastructure. The fine structure of Methanobacterium thermoautotrophicum which was grown at the optimal temperature, 65 C, as well as at the temperature extremes for growth is described. The most distinguishing feature of this organism is the presence of intracytoplasmic membranes. The internal membrane system consists of triplet membranes which are stacked closely together, frequently appearing as concentric circles without separation by cytoplasm. Aside from this feature, M. thermoautotrophicum proliferates as irregularly curved rods at 65 C and has a fine structure similar to most other gram-positive bacteria. Both low (45 C) and high (75 C) growth temperatures induce structural modifications. These structural changes include rod to spheroidal morphological changes, cell wall abberations, distortion of division septa, misdivisions, and internal membrane deterioration.


Reversal by aromatic amino acids of 2-thiazole-DL-alanine inhibition of Salmonella typhimurium. Of 21 l-amino acids tested (at 1.2 x 10(-4)m), only histidine and the aromatic amino acids (phenylalanine, tryptophan, and tyrosine) protect Salmonella typhimurium strains from inhibition of growth and immediately reverse the growth inhibition by 5 x 10(-4)m 2-thiazole-dl-alanine.


Isolation of covalently closed circular deoxyribonucleic acid from bacteria which produce exocellular nuclease. Reproducible yields of covalently closed circular (plasmid) deoxyribonucleic acid were obtained from mutants defective for extracellular nuclease but not from the corresponding wild-type strain of Serratia marcescens


Characterization of constitutive galactose permease mutants in Salmonella typhimurium. Salmonella typhimurium strains, lacking both enzyme I and the phosphocarrier protein, HPr, of the phosphoenolpyruvate-sugar phosphotransferase system, cannot transport or metabolize glucose and other sugar substrates of this enzyme system. Mutants which regain the ability to specifically utilize glucose were found to constitutively synthesize a galactose permease by virtue of a mutation in the galR gene. This permease, shown to be an active transport system, does not require HPr or enzyme I for activity.


Cell wall of Mycobacterium lepraemurium strain Hawaii. The chemical properties of the cell wall of Mycobacterium lepraemurium strain Hawaii were investigated. Five subunits of the cell wall, arabinose mycolate, mycolic acids, tetrapeptide (Ala-Gln-diaminopimelic acid-Ala), disaccharide (N-acetylglucosaminyl-beta-1,4-N-glycolylmuramic acid), and arabinogalactan, were obtained, and their chemical structures were identified.


Psychological distance in the family as schematized by families of normal, disturbed, and learning-problem children.


The response-class matrix: a procedure for recording parent-child interactions.


Expectancy of therapeutic gain: an empirical and conceptual critique.


Depth recording of averaged evoked potential of olfactory bulb.


Visual receptive fields of single neurons in superior colliculus of the ground squirrel.


Pasteurella pestis bacteriophage H and Escherichia coli bacteriophage phi II are nearly identical. Electron microscopy examination of phiII-H deoxyribonucleic acid heteroduplexes, together with polyacrylamide gel electrophoretic analyses of phage ribonucleic acid species and proteins labeled in phiII or H-infected cells, demonstrates that Pasteurella pestis phage H is nearly identical to coliphage phiII.


Rescue of DNA replication and bacteriophage production after infection with T4 DNA ligase mutants. By preventing phage DNA synthesis during a critical period, conditions have been found under which DNA replication and phage production are rescued after infection with T4 DNA ligase mutants.


Edward D. Churchill, M.D.(1895-1972).

Edward D. Churchill, M.D.(1895-1972).


Heterozygote frequencies to calculate incidence of genetic disease.


Society objects to omission of dentists in Medicaid fee adjustment.


The glass leech. Wet and dry cupping practices in the nineteenth century.


Maternal rubella and its virological diagnosis.


General review of clinical trials of rubella vaccines.


Immunity to rubella: comparison between naturally and artificially induced resistance.


Reflex pathways controlling lactation.

Reflex pathways controlling lactation.


The tissue factor pathway of blood coagulation.


Uremic bleeding.

Uremic bleeding.


Acquired inhibitors of blood coagulation.


The flow of model particles and blood cells and its relation to thrombogenesis.


Haematological and clinical parameters in assessing activity in Hodgkin's disease and other malignant lymphomas.


Pneumocystis carinii pneumonia--transplant lung.


Mortality in rat-mouse radiation chimeras.


The developmental history of the neoplastic plasma cell in mice: a brief review of recent developments.


Immunoglobulin structure determined from products of plasma cell neoplasms.


Prediction of respiratory muscle fatigue by measurements of the work of breathing.


Adjuvant therapy of generalized peritonitis with intraperitoneally administered cephalothin.


Renovascular hypertension in patients with a solitary kidney.


"Chance only favours the mind which is prepared".


Joseph Janvier Woodward and an early American view of cancer.


Energy requirement and metabolism during exposure to extreme environments.


Nutritional conditions in Yugoslavia and their reflection on health.


Nutritional requirements of the embryo.

Nutritional requirements of the embryo. This wide-ranging and extensive literature review of the nutritional requirements of the growing fetus begins by discussing the importance of the mother for fetal well-being, turns next to the growth requirements of the embryo, discusses the quantitative and qualitative requirements for proper embryo nutrition (i.e., qualitative implies the proper balance of nutrients), and then focuses on specific substance requirements, including protein, lipid, and carbohydrates; vitamins; and inorganic substances.  Specific numbers are given tabularly for each substance requirement.  And the review ends by pointing out that the best way to achieve quantitative and qualitative nutrition is by understanding the nutritional value of various foods as well as by understanding the metabolism of the mother during pregnancy and the effect that maternal changes during pregnancy have on the growing fetus.


Review of 54 complete denture wearers. Patients' opinions 1 year after treatment.


Vertical isometric muscle forces of the mandible. A comparative study of subjects with and without manifest mandibular pain dysfunction syndrome.


Sinus venosus atrial septal defect: analysis of fifty cases.


Vascular reactivity in systemic arterial hypertension.


Evaluation of bacteriological transport media.


Timely topics in microbiology: antibiotics 1969-1971.


Insulin transformation in the liver.

Insulin transformation in the liver.


Dual hypothalamic feeding system in a migratory bird, Zonotrichia albicollis.


Burn wound therapy.

Burn wound therapy.


Physiologic responses of the ano-rectal sphincters in children with incontinence and constipation problems.


Microbiologic study of wound infections in tornado casualties.


Mating reaction in Saccharomyces cerevisiae. 3. Changes in autolytic activity.


Studies on lipid and carbohydrate metabolism in the rat. Effects of diet on body composition, plasma glucose and insulin concentrations, insulin secretion in vitro and tolerance to intravenous glucose and intravenous glucose and intravenous insulin.


Distribution of G cells in the canine gastrointestinal tract.


L-Asparaginase from Proteus vulgaris. Subunit and amino acid composition.


An active antibody fragment (Fv) composed of the variable portions of heavy and light chains.


Rubradirin, an inhibitor of ribosomal polypeptide biosynthesis.


Isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B. Effects of magnesium and spermine on the amino acid activation reaction.


Interaction of tetracylines with ribosomal subunits from Escherichia coli. A fluorometric investigation.


Properties of the fluorescence probe response associated with the transmission mechanism of colicin E1.


On the role of membrane phase in the transmission mechanism of colicin E1.


Transfer ribonucleic acids from mouse plasmacytoma tumors producing kappa and   immunoglobulin chains.


Diagnostic ultrasound in renal disease.

Diagnostic ultrasound in renal disease.


Renal toxicity of radiological contrast media.


Isotopes and the kidney.

Isotopes and the kidney.


Topographical scintigraphy of the kidney.


Radiological patterns of bone disease associated with renal glomerular failure in adults.


The nephrographic pattern during excretion urography.


The renal tract in spina bifida cystica.


Some pioneers in comparative medicine.

Some pioneers in comparative medicine.


The effects of immunization to L-asparaginase on antitumor and enzymatic activity.


Frequency of fish tumors found in a polluted watershed as compared to nonpolluted Canadian waters.


In vitro neoplastic transformation of hamster embryonic skin and subcutaneous tissue cells with small-plaque and large-plaque variants of an avian adenovirus (chicken embryo lethal orphan).


Alteration of cell-mediated immunity in the mouse following administration of 4-nitroquinoline 1-oxide.


Obituary. Richard J. Winzler.

Obituary. Richard J. Winzler.


Computer case finding as an aid in surgical review and continuing education in a community hospital.


Topical administration of vitamin A acid (retinoic acid) in palmar keratoses: callosities, hyperkeratotic eczema, hypertrophic lichen planus, pityriasis rubra pilaris.


Invasion of a house by the dog parasite Cheyletiella yasguri (Smiley 1965), a mite causing prurigo in man.


A qualitative and quantitative histological study of the islets of Langerhans in diabetes mellitus.


Phenformin in insulin dependent diabetes.


A lymphocyte cytotoxicity rebound phenomenon induced by enhancing sera.


Resistance of irradiated F 1  hybrid and allogeneic mice to bone marrow grafts of NZB donors.


Isolation of an immunosuppressive peptide fraction from human plasma.


Immunoglobulin synthesis in bullfrog larvae.


Studies on antibody induction in vitro. I. The nature of the primary response to soluble T2 antigens by rabbit spleen cells.


Effect of phenol extraction of group A streptococcus on titer and specificity of fluorescent M-typing antisera.


Comparison of Vibrio parahaemolyticus cultures isolated in the United States with those isolated in Japan.


Transplacental transmission of bovine rabies after natural infection.


Modification of enterosorption in experimental enteric colibacillosis of swine inoculated with Escherichia coli.


Experimental pyelonephritis: a new method for inducing pyelonephritis in the rat.


Reliability of the treponemal hemagglutination test for the serodiagnosis of syphilis.


Medicare appeals process.

Medicare appeals process.


Maine Medical Association. Official roster.


Scientific advances in transfusion.

Scientific advances in transfusion.


Thrombophlebitis with diazepam used intravenously.


Updated Hodgkin's disease. C. Advanced disease and special problems. Comment: the non-Hodgkin's lymphomas.


Marihuana and tidal volume.

Marihuana and tidal volume.


Medical literature in the early 19th century.


The role of sports in rehabilitation of the handicapped. 1B. Historical.


Coronary care. The understanding and treatment of atrial and ventricular dysrhythmias.


Myocardial infarction complicated by conduction defect.


The failing myocardium. II. Assisted circulation.


Direct coronary artery surgery.

Direct coronary artery surgery.


Surgical management of complications of myocardial infarction.


Hemodynamic effects of acute myocardial infarction.


Epidemiology of coronary heart disease.

Epidemiology of coronary heart disease.


Myocardial ischemia and coronary artery atherosclerosis. A comprehensive approach to postmortem studies.


Mechanical stresses on vessels and the non-uniform distribution of atherosclerosis.


Dilemma of "battered child" and "battered children".


Treatment and prevention of stroke. II. Cerebrovascular insufficiencies.


Douglas Brian Fairley.

Douglas Brian Fairley.


H.J.J.L. Van Dyk.

H.J.J.L. Van Dyk.


Medical and social aspects of the great plague of London in 1665.


House dust mites and respiratory allergy: a qualitative survey of species occurring in Finnish house dust.


The role of introital enterobacteria in recurrent urinary infections.


Robert Jerome Prentiss: 1909-1972.

Robert Jerome Prentiss: 1909-1972.


Presentation of Barringer medal to Dr. Wyland F. Leadbetter.


Renal transplantation in Fabry's disease.


The effects of irradiation on canine renal homografts placed in the portal circulation.


The middle aortic syndrome: report of a case treated by renal autotransplantation.


J.A. Campbell Colston: 1886-1971.

J.A. Campbell Colston: 1886-1971.


Homer G. Hamer: 1880-1971.

Homer G. Hamer: 1880-1971.


T. Leon Howard: 1880-1971.

T. Leon Howard: 1880-1971.


Transureteroureterostomy in children.

Transureteroureterostomy in children.


Genetic bases of urogenital apparatus deformities and new perspectives in transplantation.


The family structure of school phobics.

The family structure of school phobics.


A survey on the distribution of psychiatric syndromes seen in children in three major groups of changing Turkish culture.


Dissociation of the insulin releasing and the metabolic functions of hexoses in islets of Langerhans.


Transcriptional role in DNA replication: degradation of RNA primer during DNA synthesis.


Heterogeneous changes in amino acid transport activity in E. coli lipid overproducing mutants.


Role of DNA transcription in the initiation of Escherichia coli sex factor (F) DNA replication.


Function of Y in codon-anticodon interaction of tRNA Phe .


NMR study of the modified base resonances of tRNA tyr-  coli .


The 3'-terminal nucleotide sequences of lambda DNA.


Kinetic and binding effects of 1,N 6 -ethenoadenosine triphosphate to aspartate transcarbamylase.


The binding of RNA to various celluloses.


Evidence for nucleation in the folding of reduced hen egg lysozyme.


Galactoside transport dissociated from proton movement in mutants of Escherichia coli.


A hydridase from Escherichia coli.

A hydridase from Escherichia coli.


Removal of Y-37 from tRNA phe  yeast  alters oligomer binding to two loops.


Interaction of the glucose tolerance factor (GTF) with insulin.


Persistence of P1 transducing DNA in recipient cells.


Pituitary binding sites for ( 3 H)-labelled luteinizing hormone releasing factor (LRF).


The nucleotide sequency of tRNA Gly  from yeast.


Synthesis of luteinizing hormone-releasing hormone containing tritium-labelled pyroglutamic acid.


Studies of viral structure by Raman spectroscopy. I. R17 virus and R17 RNA.


In vitro effect of d-lysergic acid diethylamide on immunoglobulin synthesis.


Subcellular distribution and characterization of endo and exo-cellular proteases in E. coli.


B. stearothermophilus initiation factors and their properties in E. coli and B. stearothermophilus protein initiation systems.


The denture surface.

The denture surface.


Succinyl coenzyme A synthetase of Escherichia coli: initial rate kinetics of succinyl-CoA cleavage and isotope exchange studies.


Studies on the effects of growth hormone and thyroxine on proinsulin synthesis and insulin formation in the isolated islets of Langerhans of the rat.


Mobilization of haemopoietic stem cells (CFU) into the peripheral blood of the mouse; effects of endotoxin and other compounds.


Color-coding casts for laboratory use.

Color-coding casts for laboratory use.


Adding weight may promote retention of lower denture.


Effects of neutral and dibasic amino acids on the in vitro release of insulin.


Experimental pyelonephritis: relationship with L-forms of Escherichia coli.


Disseminated candidosis in cyclophosphamide induced leucopenic state: an experimental study.


Stubbins' arthroplasty for fractures of the tibial condyle.


The hip in the myelomeningocele child.

The hip in the myelomeningocele child.


Pathogenesis of trypan blue induced experimental hydrocephalus in rats.


Virulence of Shigella flexneri hybrids expressing Escherichia coli somatic antigens. The genes controlling either Escherichia coli somatic antigen 8 or 25 were conjugally transferred to virulent Shigella flexneri 2a recipients to determine whether the aquisition of these antigens would affect the virulence of the resulting hybrid. A high proportion of such hybrids were found to be rough and hence were avirulent. Some smooth S. flexneri hybrids which replaced their native group antigens with E. coli factor 25 were still virulent in the animal models employed. All S. flexneri O-8 hybrids were uniformly avirulent. Our finding, that S. flexneri hybrids with the chemically divergent E. coli O-8 repeat unit are avirulent whereas some hybrids with the chemically related O-25 repeat unit retain virulence, suggests that the chemical composition and structure of the O side chain of somatic antigens may represent one determining factor for bacterial penetration of mucosal epithelial cells, the primary step in the pathogenesis of bacillary dysentery.


Hip problems in systemic disease.

Hip problems in systemic disease.


Intracellular fate of Cryptococcus neoformans. Human peripheral leukocytes were found to engulf and kill cells of Cryptococcus neoformans. Fewer encapsulated than nonencapsulated cells met this fate, since cryptococcal capsular polysaccharide inhibited phagocytosis. During 10 to 12 hr of incubation of nonencapsulated cells in human serum, sufficient polysaccharide was produced to inhibit phagocytosis by 50%. The polysaccharide inhibitor was found in the sera of four patients with cryptococcosis, but not on the surfaces of their leukocytes. Additional experiments indicated that serum is not essential for effective phagocytosis. However, normal human serum contains anticryptococcal activity which is not inhibited by capsular material. Preliminary findings indicate that the phagocytic index of a patient with cryptococcosis may be correlated with the severity of his disease.


Effects of passive antibody on early pathogenesis of Marek's disease. The effects of passive Marek's disease virus (MDV) antibody were characterized in three experiments in which 1- or 2-day-old PDRC chickens were inoculated with cell-associated MDV. Antibody acquired naturally from the dam, or injected prior to, or at the time of, virus inoculation, failed to prevent infection, but the incidence and severity of the acute necrotizing disease were reduced. Also, the number of tissues with viral antigen (fluorescent antibody test) and the amount of antigen in positive tissues was lowered, and fewer infected cells in spleen (in vitro assay) were detected in antibody-positive chicks. Serum containing MDV antibody was efficacious when injected prior to infection and had some protective effect when first given at day 4 but not at day 7 after virus inoculation. Normal antibody-free serum was ineffective, and chickens with naturally acquired (maternal) antibody against turkey herpesvirus (a virus antigenically related to MDV) were not protected against MDV infection.


Hip problems associated with organ transplants.


Tumor induction by Cryptococcus neoformans. A human isolate of Cryptococcus neoformans strain CIA, which was originally obtained in 1963, produced fatal disease in mice. Postmortem examinations showed extensive central nervous system disease. After using this yeast for research for 7 years, we found that it began to produce large tumors after intraperitoneal inoculation in mice. The present study showed that the tumors consisted of large agglomerates of yeast cells, capillaries, and reticular stroma. In concomitant experiments, the same C. neoformans strain, introduced into the lungs of mice in an aerosol, produced asymptomatic infections. A definition for the term "cryptococcoma" is proposed.


Use of acid etchant on fresh preparations to improve definition of impressions and remove temporary cement. I. A review of the literature.


The care of the mentally ill, and psychiatric nursing in Malta.


Photochemical reactions of natural macromolecules. Photoreactions of proteins.


Russell E. Marker. Pioneer of the Mexican steroid industry.


General practitioner series-8. Ultrasonics in periodontal therapy.


Antimalarial activity of clopidol, 3,5-dichloro-2,6-dimethyl-4-pyridinol, and its esters, carbonates, and sulfonates.


Hydroxylamine derivatives as potential antimalarial agents. 2. Hydroxamates and amidoximes.


Hydroxylamine derivatives as potential antimalarial agents. 3. 1,2,4-Oxadiazoles.


Fluorescent antibody application in the diagnosis of fungal diseases.


Paravertebral lumbar meningomyelocele. Report of two cases.


An ultrastructural study of methylmercury-induced primary sensory neuropathy in the rat.


Studies concerning the regional lymph node in cancer. V. Histologic and ultrastructural findings in regional and nonregional nodes.


The inhibition of phagocytosis and facilitation of exocytosis in rabbit polymorphonuclear leukocytes by cytochalasin B.


Vacuolation: a function of cell age in porcine ileal absorptive cells.


Irving Burka, M.D.

Irving Burka, M.D.


Leukocyte recruitment through airway walls by condensed vegetable tannins and quercetin.


Embalming through the ages.

Embalming through the ages.


Corneal grafting.

Corneal grafting.


Effects of intracerebral 5-hydroxytryptamine injection on themoregulation in rat.


Pole reversals and hypothalamic self-stimulation: ascending spread of rewarding excitation.


The effect of VMH lesions, lateral cuts and anterior cuts of food intake, activity level, food motivation, and reactivity to taste.


The motivational properties of electrical stimulation of the medial and paraventricular hypothalamic nuclei.


Two-way avoidance responding following VMH lesions: effects of varying shock intensity.


The safety of diagnostic ultrasound. A review.


A further comparative trial of co-trimoxazole in chronic bronchitis.


Mozart. His health and death.

Mozart. His health and death.


Response to luteinizing hormone releasing factor (LRF) in normal subjects and anovulatory patients.


Post mortem changes of human serum esterases. An electrophoretic study.


Adjunct therapy in chronic obstructive pulmonary disease.


The nephropathy of the nail-patella syndrome. Clinicopathologic analysis of 11 kindred.


The effect of circulation time on the neuromuscular action of suxamethonium.


Granulocytopenia associated with carbenicillin. Five episodes in two patients.


The binding of Escherichia coli ribosomes to matrix bound messenger RNA.


Interaction of the radioactive translation initiation factor IF 3  with ribosomes.


The determination of the primary structure of the 16S ribosomal RNA of Escherichia coli. 1. Nucleotide sequence analysis of T 1  and pancreatic ribonuclease digestion products.


The determination of the primary structure of the 16S ribosomal RNA of Escherichia coli. 2. Nucleotide sequences of products from partial enzymatic hydrolysis.


Mechanism of vitamin B 12  malabsorption in blind loop syndrome: bacterial uptake of vitamin B 12  and stability of binding of vitamin B 12  to gastric intrinsic factor.


Electron microscopic observation on the cytologic smears.


Obituary. Dr. John James Carroll (1909-1972).


The effect of volatile anaesthetics on bacterial growth.


Patients with cardiac valve prosthesis: subsequent anaesthetic management for non-cardiac surgical procedures.


Progress in swine nutrition for the veterinarian.


Effect of heparin on gentamicin concentration in blood.


The structure of transcriptional units in eukaryotic cells.


Sporulation of bacilli, a model of cellular differentiation.


Diphenylhydantoin. Its use in detecting early insulin secretory defects in patients with mild glucose intolerance.


Bernardo Alberto Houssay.

Bernardo Alberto Houssay.


Amplification of B cell clones forming antibody to the 2,4-dinitrophenyl group.


The lipid A immunity system. I. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component.


Migration inhibition experiments with mixtures of human peripheral blood lymphocytes and guinea pig peritoneal exudate cells.


The enhancement of a primary in vitro anti-hapten response by carrier priming.


Thymus cells are inducible to osteogenesis.


Gerodontics: a new specialty.

Gerodontics: a new specialty.


Review for prepayment. Where is it now? Council on Dental Care Programs.


Materials for oral implantation--biological and functional criteria.


A unifying concept of the TMJ pain-dysfunction syndrome.


Overdentures--theory and technique.

Overdentures--theory and technique.


Experience in preparing patients for renal transplantation using haemo and peritoneal dialysis.


Amalgam: past, present, and future.

Amalgam: past, present, and future.


Renal transplantation.

Renal transplantation.


Renal transplantation & chronic haemodialysis.


Bacteriology of urinary tract infections and the effectiveness of antimicrobials against the urinary pathogens.


Double-blind cross-over study of fenfluramine (Ponderax) in obesity.


Pancreatic glucagon--curent concepts of an old hormone.


Adhesion in dentistry.

Adhesion in dentistry.


Cell-mediated immunity and blocking serum activity to tolerated allografts in rats. W/Fu rats were neonatally inoculated with bone marrow cells from B/N rats and vice versa. Of the inoculated rats, some were capable of accepting a foreign (B/N or W/Fu) skin graft over the period of observation (i.e. for more than 100 days), while other rats rejected their skin grafts as early as control animals (within 8-12 days) or after a prolonged period of acceptance (20-96 days). Using a microcytotoxicity test, it could be shown that both those rats that rapidly rejected skin grafts and those that kept their grafts during the observation period had lymphocytes capable of destroying cultivated allogeneic cells from the respective strains with whose cells the rats had been inoculated as newborns. The degree of lymphocyte reactivity decreased upon time, so that 4 of 13 rats that had carried "tolerated" skin grafts over more than 84 days had lymphocytes which were nonreactive in the highest dose tested, and the degree of reactivity in the other 9 rats was less than seen early after tolerance induction. Rats that were capable of accepting skin grafts over prolonged periods of time had sera that could specifically block lymphocyte-mediated cytotoxicity, while sera from rats that had rejected their grafts did not block. Sera from rats that rejected their skin grafts after 20-96 days lost the blocking activity 3-10 days before rejection.


The glomerular mesangium. 3. Acute immune mesangial injury: a new model of glomerulonephritis. A mechanism of immune glomerular injury is described based on the fixation of antibody (Ab) to an antigen (Ag) that has localized in the glomerular mesangium. Rabbits were given, intravenously (i.v.), aggregated human IgG (AHIgG) or albumin (AHSA) and 10 h later, when the Ag by immunofluorescent microscopy was present in the mesangium, a kidney was removed and transplanted into a normal rabbit. The recipient then received, i.v., rabbit anti-HIgG or anti-HSA. Within minutes of Ab infusion, glomeruli of the donor kidney had polymorphonuclear (PMN) infiltration that over the next few hours became marked and was associated with glomerular cell swelling. At 24 h a decrease in PMN's and early mesangial proliferation was seen. By 3 days there was marked mesangial hypercellularity and increased mesangial matrix. Within minutes after Ab administration rabbit IgG, C3, and fibrin were seen in the glomerular mesangium. There was a fall in complement titer by 1 min after Ab infusion that was due to complement consumption by the donor kidney. Complement then returned to normal levels by 48 h. Significant glomerular injury did not occur (a) in the recipient's own kidney, (b) from Ag administration and transplantation without recipient Ab administration, or (c) from transplantation and Ab administration without prior Ag administration. These studies demonstrated that Ag localized in the glomerular mesangium can react with circulating Ab and complement resulting in severe glomerular injury.


Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes. A population of thymus-derived lymphocytes has been identified that, upon activation by the nonspecific plant mitogen concanavalin A, suppresses the development of plaque-forming cell responses in fresh or 48-h antigen-stimulated cultures of mouse spleen cells. Suppressor cells can inhibit both primary and secondary IgM and IgG responses in vitro. X-irradiation before activation of peripheral thymus-derived cells by concanavalin A abrogates generation of suppressor cells. After a 48 h activation period, however, the function of concanavalin A-activated suppressor cells is radioresistant. As yet uncertain is whether these suppressor cells are a population of cells distinct from thymus-derived "helper" cells. In certain important regards, the cells mediating these two opposing functions share similar characteristics; the effect observed may be determined by the circumstances of activation or the numbers of activated cells, and may consequently represent different functions of a single thymus-derived regulator cell population.


The cytotoxic effect of mouse macrophages on syngeneic and allogeneic erythrocytes. A cytotoxic effect of mouse peritoneal macrophages against syngeneic and allogeneic erythrocytes was demonstrated by isotope release and release of hemoglobin. The cytotoxic effect was dependent on the contact between viable, activated macrophages and target cells. Activation was accomplished by prolonged cultivation of macrophages and by the presence of Zn(++) and Con-A. Immunization did not prove necessary. Morphological observations as well as experiments with various salt concentrations indicate that the cytotoxic reaction may involve some kind of osmotic effect upon the target cells.


Frederic Henry Gerrish--Maine's outstanding figure in academic and clinical medicine 1873-1920.


A study of allograft kidney rejection occurring simultaneously in whole organ and ear chamber grafts in the rabbit. When portions of adult renal tissue are allografted into the rabbit ear chamber, they usually survive for periods of up to several months (6). When a kidney from the same donor is grafted as a whole organ, the ear chamber grafts then reject with the whole organ in 7 days. During that time serial needle biopsies of the whole organ are compared with the in vivo appearance of the ear chamber grafts. This establishes that the changes occurring in the ear chamber grafts are monitoring the rejection process proceeding in the whole organ grafts. Dramatic vascular changes herald the earliest stages of unmodified rejection. A highly characteristic form of individual discrete platelet adhesion to both endothelium and adherent leukocytes is observed which is associated with the release reaction. At times as many as 20 such discrete platelets are clearly visible in profile in one high-power field. This demonstrates in vivo a mechanism whereby vascular and parenchymal damage may be produced by platelet contents, without previous aggregation or thrombus formation being necessary.


Medicaid adds child screening emphasis.

Medicaid adds child screening emphasis.


Will ADA swing into inaction again?

Will ADA swing into inaction again?


Alexander Graham Bell of Baddeck.

Alexander Graham Bell of Baddeck.


Presentation of Howland award to Waldo E. Nelsen.


Musical expression of psychopathology (Anton Dvorak).


Was Shibasaburo Kitasato the co-discoverer of the plague bacillus?


The artificial induction of coat colour--a final report and a review.


Effects of lead acetate on sensitivity to shock, intravascular carbon and endotoxin clearances, and hepatic endotoxin detoxification.


Suppression of established Friend virus leukemia by statolon. V. Reversal of virus-induced immunodepression to sheep erythrocytes.


The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis.


Enzymatic synthesis of growth hormone releasing factor (GH-RF) by rat incubates and by extracts of rat and porcine hypothalamic tissue.


Measurement of antibodies to Machupo virus by the indirect fluorescent technique.


Effect of phlebotomy on coronary blood flow in calves with brisket disease.


Effect of the volume of intravenous infusion of normal saline on gastric secretion in rats.


The use of  14 C-cyanate for red blood cell survival studies.


Influence of cytochalasin B on hyphal morphogenesis of Aspergillus nidulans.


Tension pneumopericardium following assisted ventilation in hyaline membrane disease.


In memoriam. Gonzalo P. Elizondo-Martel, M.D. 1898-1972.


The American College of Radiology: fiftieth anniversary.


The emergence of the American Registry of Radiologic Technologists.


American Registry of Radiologic Technologists.


Drip-infusion cholangiography: a second look.


Computer approach to diagnosis in regional dental pain.


Succinate dehydrogenase.

Succinate dehydrogenase.


Control of enzyme levels in mammalian tissues.


Physical organic models for the mechanism of lysozyme action.


Sensitivity to oxygen at high pressure of radioresistant and radiosensitive strains of bacteria.


Threonine deaminases.

Threonine deaminases.


Heparin, platelets, and venous thrombosis.


Electronic calibration for indocyanine dye-dilution curves.


Transvenous biopsy from canine orthotopic heart allografts.


Thromboembolism and oral contraceptives.


A review of antibiotic therapy in patients with systemic infections.


The pathogenesis of epizootic hemorrhagic disease of deer: an electron microscopic study. Ultrastructural studies on capillaries and arterioles from tongue and heart tissues of 3 deer and from a portion of the cerebral hemisphere of a deer experimentally infected with epizootic hemorrhagic disease (EHD) virus revealed striking changes in the vascular endothelial cells. These changes included the focal development of moderately electron-dense materials (viral matrices), aggregations of virus particles and tubules in the cytoplasm. In addition, enlargement of endothelial cells and degenerative changes in some of the endothelial cells were frequently observed. The lumens of affected capillaries and arterioles were often noted to be occluded by fluffy, moderately electron-dense substances or by aggregates of highly electron-dense fibrin which appeared to be adherent to the surface of endothelial plasma membrane. Platelets were frequently present in the capillaries, intermingled with fibrin materials, and appeared either intact or partially or completely degranulated. These observations suggest that viral injury to endothelial cells resulting from EHD virus replication may initiate intravascular thrombosis, and that the hemorrhagic lesion is a manifestation of virus-cell interaction.


The effect of glucose-insulin-potassium on cardiac ultrastructure following acute experimental coronary occlusion. The effects of glucose-insulin-potassium (GIK) on cardiac ultrastructure following acute experimental coronary occlusion were studied in dogs. Epicardial ST segment elevations at multiple sites on the anterior surface of the left ventricle 15 minutes after ligation of the left anterior descending coronary artery were used to predict infarct development. Biopsies removed from sites of known ST segment elevation were examined with the electron microscope, and the degree of injury was correlated with the ST segment elevation. The animals receiving GIK showed significantly less necrosis than was seen in dogs with occlusion alone at corresponding levels of ST segment elevation. Other evidence suggesting a beneficial effect of GIK was the presence of a fibrillar material in several biopsies from the treated animals, which may indicate the regeneration of myofilaments.


Stroke: a history of its rehabilitation. Walter J. Zeiter Lecture.


The reticulum cell sarcoma--microglioma group of brain tumours. A consideration of their clinical features and therapy.


Henri Ey's concepts of the organization of consciousness and its disorganization: an extension of Jacksonian theory.


Travelers' diarrhea.

Travelers' diarrhea. On the average, one-fourth of North Americans visiting developing countries experience a self-limited diarrheal illness that interferes with holiday or business activities. Recent work suggests that these episodes are caused by a small inoculum of enteropathogenic Escherichia coli which are common in the country visited and rare in the country of origin. Neither antimicrobial treatment nor anti-diarrheal agents have proven benefit once the illness has begun. Despite its frequent use, iodochlorhydroxyquin has not been shown in double blind studies to be effective as a preventive agent, and may be dangerous. The status of furazolidone for prevention of tourist diarrhea is questionable. Both neomycin sulfate and phythalylsulfathiazole have demonstrated efficacy as chemoprophylactics in Mexico. However, their use should be restricted to limited types of travel and travelers. General admonitions concerning avoidance of certain ingestibles are recommended; despite questionable value in preventing travelers' diarrhea such precautions may prevent more serious gastrointestinal illness.


Delhi belly, Hong Kong dog, Casablanca crud, Montezuma's revenge, Turista.


Necrotizing enterocolitis--a medical approach to treatment. Ten cases of necrotizing enterocolitis occurred among 5400 infants delivered consecutively during a two and one-half year period at the Halifax Infirmary. Since this disease involved such extensive areas of the intestinal wall, medical management was employed exclusively, even when intestinal perforation occurred. Nine of the ten infants survived.In this series there was a high incidence of prematurity, prolonged interval between rupture of the placental membranes and delivery, severe asphyxia neonatorum and subsequent hypotension and metabolic acidosis. Blood cultures grew Klebsiella aerobacter or E. coli in 7/10 infants. Only two of these organisms were sensitive to kanamycin and all were resistant to ampicillin. Administration of ampicillin to the mothers did not protect these infants against necrotizing enterocolitis. Edema of the gut wall appeared to be an important early sign. Stricture formation occurred in 4/10 cases, all in the terminal ileum. These infants were operated upon only after the acute stage of the disease had subsided.


Psychiatric problems in the aged: a reconsideration. The numerically important mental disorders found in the senescent population are reviewed from the point of view of their relationship to the process of ageing. Only two direct relationships are seen: the acute confusional states due to the age-linked decline in stress resistance; and the neurotic reactions due to the diminished capacity for rapid and adequate adjustment to the more subtle but chronic sociopsychological changes the aged individual is so frequently exposed to in our society. The chronic dementing processes of the senium, senile and arteriosclerotic dementia, are more likely to occur at an advanced age, but apparently are not the final outcome of cerebral and/or cerebrovascular ageing, although the ageing process seems to favour their phenotypical manifestation. The functional psychoses may occur at an advanced age but are not directly related to the process of ageing.


Experiences with a second generation of stapling instruments in general and thoracic surgery.


A new stapling instrument for automatic ligation and division of tissues.


The recognition of Streptococcus mutans.


Urinary excretion of tyrosine metabolites in spina bifida.


Recent developments and trends in French psychiatry.


Identification by immunofluorescence of prolactin-producing cells in the hypophysis of the newt, Triturus cristatus carnifex Laur.


Mass fragmentography as an application of gas-liquid chromatography-mass spectrometry in biological research.


RNA fractionation on modified celluloses. 3. BD-cellulose.


Disc electrophoresis of extracts from the taste buds located in circumvallate papillae of rat tongues. The epithelium of the circumvallate papillae of rat tongues was stripped off by treatment with 0.005% elastase in a state when many taste buds were present. The taste buds were isolated from the stripped epithelium by further treatment with 0.005% elastase and 0.08% trypsin. A protein which was thought to be characteristic of taste buds was found from semimicro disc polyacrylamide gel electrophoretic studies of the stripped epithelia with and without taste buds. This result was supported by micro disc polyacrylamide gel electrophoretic studies of isolated taste buds.


Morphologic heterogeneity of the Mycoplasmatales.


Current problems in the isolation and identification of Mycoplasma.


Workshop on the Mycoplasmatales as agents of disease. Session I. Biology of the Mycoplasmatales. Summary of discussion.


Comparative serology of Mycoplasma pulmonis.


Immunologic cross-reactions of enterotoxins from Escherichia coli and Vibrio cholerae.


More sensitive methods for detection of antibody to Mycoplasma pneumoniae.


How to make duplicate dentures for use as final impression trays.


Significance of coagulase-negative Staphylococcus in urine.


Transport of glucose and amino acids in human jejunum during Asiatic cholera.


Colin Munro MacLeod, 1909-1972.

Colin Munro MacLeod, 1909-1972.


Genital mycoplasmas in postpartum fever.


An analysis of clasp leverage in removable partial dentures.


Predictors of response to amitriptyline and placebo in three outpatient treatment settings.


Immunofluorescent skin test in systemic lupus erythematosus. Lack of relationship with renal disease.


American Association of Hospital Dentists, active, affiliate and associate membership roster.


A model for drug use with depressed patients.


Doctor Josiah Gregg, scientist of the southwest, portrayer of the Santa Fe Trail.


Joseph M. Toner (1825-1896) as a medical historian.


Homage to Walter Pagel.

Homage to Walter Pagel.


The medical caricatures of Thomas Rowlandson.


Oxybate sodium for parkinsonism.

Oxybate sodium for parkinsonism.


Doctors at table.

Doctors at table.


The muse and the martini.

The muse and the martini.


John Keats, physician and poet.

John Keats, physician and poet.


Paintings and personalities.

Paintings and personalities.


Fildes and "The Doctor".

Fildes and "The Doctor".


James Joyce. A portrait of the artist as a schizoid.


The doctor and the detective story.

The doctor and the detective story.


Medical advice in seventeenth-century journalism.


Preoperative evaluation of the patient with pulmonary disease.


Multiple sclerosis and three professors of pathologic anatomy.


Ettie Lyons.

Ettie Lyons.


Echocardiography.

Echocardiography.


The genetics of diabetes.

The genetics of diabetes.


V. Conference summary. Chemical diabetes in childhood.


Location of gene specifying cytosine deaminase in Escherichia coli.


Genetic studies of the ribosomal proteins in Escherichia coli. 8. Mapping of ribosomal protein components by intergeneric mating experiments between Serratia marcescens and Escherichia coli.


On the specificity of caffeine effects. Inhibition by caffeine of RNA and protein synthesis in yeast and Escherichia coli.


The cellular immune response in experimental Escherichia coli pyelonephritis in the rat.


Renal lesions in heroin addicts. A study based on kidney biopsies.


A tuberculoma review with some personal experiences. I. Brain.


A tuberculoma review with some personal experiences. II. Spinal cord and its coverings.


Measurement of sleep.

Measurement of sleep.


Obituary: Dr. P. B. Ramanujam.

Obituary: Dr. P. B. Ramanujam.


The value of histologic identification of mediastinal masses in children.


Effects of hypothalamic stimulation, acclimation and periodic withdrawal on ethanol consumption.


The use of silicones in plastic surgery. A retrospective view.


Increased conditioned gustatory aversion following VMH lesions in rats.


The role of the orthopedic hospital in the Shriners burns program.


Posterior decortication potentiates retrograde amnesia from hippocampal stimulation.


Studies of urethral healing in dogs.

Studies of urethral healing in dogs.


Use of a prefolded flap to provide lining and cover in the repair of cervical fistulae.


Summated cerebral responses to taste stimuli in rat.


The olfactory control of meal pattern in rats.


Treatment of deflection of the anterocaudal portion of the nasal septum.


Behaviorally determined neurophysiological properties of MFB self-stimulation fibers.


Influence of contingent amygdaloid stimulation on lateral hypothalamic medial forebrain bundle self-stimulation.


Mandibuular vestibuloplasty with a free graft of the mucoperiosteal layer from the hard palate.


Use of the flag flap for coverage of a small area on a finger or the palm. 20 years experience.


Attenuation of brain stimulation self-starvation: adaptation effects.


Stereotaxic instrument for aseptic placement of electrodes in small animals.


Compound silicone-bone implants for mandibular reconstruction. Development and application.


Robert H. Ivy, M.D., D.D.S. A tribute.

Robert H. Ivy, M.D., D.D.S. A tribute.


On the lack of any effect of gravity on the survival of tubed flaps. An experimental study in rabbits and pigs.


Late development of squamous cell carcinoma in a split-skin graft lining a vagina. Case report.


Disseminated candidiasis in a severely burned patient. Case report.


Closure of a large myelomeningocele. Case report.


Instrumental conditioning of photic evoked potentials: mechanisms and properties of late component modification.


Robert Emmett Moran, M.D.; 1896-1972.

Robert Emmett Moran, M.D.; 1896-1972.


The neuroblastoma.

The neuroblastoma.


Pleuro-pulmonary suppuration in neonates and infants.


Psychiatry: paradigm of our times.

Psychiatry: paradigm of our times.


Aharon Katzir-Katchalsky, 1913-1972.

Aharon Katzir-Katchalsky, 1913-1972.


Lister unobserved.

Lister unobserved.


The initial management of the emergency case in small animals.


Shock--basic pathophysiology and treatment.


Cardiac emergencies.

Cardiac emergencies.


Management of respiratory emergencies in small animals.


Urinary tract emergencies and renal care following trauma.


Medical emergencies of the digestive tract.


Surgical management of abdominal emergencies.


Management of ocular emergencies.

Management of ocular emergencies.


Chemical poisonings in small animal practice.


Pulmonary resuscitation and anesthesia in trauma cases.


Prevention and treatment of cardiovascular emergencies during anesthesia and surgery.


Intensive care.

Intensive care.


Newer concepts in the regulation of food intake.


Alcohol, the pancreas, pancreatic inflammation, and pancreatic insufficiency.


The role of pancreatic exocrine secretions in the absorption of vitamin B 12  and iron.


Treatment of fistula-in-ano by a new technique. Review and follow-up of 200 cases.


Magnesium and the pancreas.

Magnesium and the pancreas.


Current concepts in shigellosis.

Current concepts in shigellosis.


Some speculations concerning a possible biochemical basis of minimal brain dysfunction.


Social aspects of minimal brain dysfunction.


Minimal brain dysfunction from a neuropsychological point of view.


Psychological assessment of children with minimal brain dysfunction.


How amphetamine acts in minimal brain dysfunction.


(Des-Gly-NH 10  2 , pro-ethylamide 9 )-LH-RH: a highly potent analog of luteinizing hormone releasing hormone.


Gram-negative pneumonias in surgical patients. Complication of antibiotic treatment.


Recognition of template RNA by Q  polymerase: sequence at the 3'-terminus of Q  6S RNA.


Preservation of canine kidneys with hypothermic nonpulsatile perfusion.


Ureteroneocystostomy in kidney transplant with ureteral duplication.


Orbital reconstruction after radical resection.


Equine paralytic myoglobinuria ("azoturia"): a review.


Characteristics of the reversible heat, solvent, and detergent denaturation of leucine binding protein.


The thyroid gland--a review.

The thyroid gland--a review.


Binding of actin to heavy meromyosin in the absence of adenosine triphosphate.


Pseudouridine, isolation and biosynthesis of the nucleoside isolated from the culture filtrates of Streptoverticillium ladakanus.


Dissociation of Escherichia coli ribosomes. Role of initiation factors.


Erythromycin, a peptidyltransferase effector.


The decisive period in the primary infection of muscle by Escherichia coli.


Activity of the reticuloendothelial system and the antibody response. II. Effect of stilboestrol on the immune response to sheep erythrocytes in the mouse.


Nature of hyperacute (accelerated second set) rejection in dog renal allografts and effects of heparin on rejection process. Renal allografts were exchanged between unrelated mongrel dogs after previous sensitization with skin and kidney grafts from the same donors. Rapid rejection of the renal allografts was associated with the accumulation of platelets and leucocytes in the peritubular and glomerular capillaries but fibrin deposition was not demonstrated.Heparin infusion delayed but did not prevent the rejection process.


Extended deep femoral angioplasty.

Extended deep femoral angioplasty. At present reconstructive arterial surgery for atherosclerotic disease below the level of the inguinal ligament is restricted to femoropopliteal bypass grafts. We have found a new operation, which we call extended deep femoral angioplasty, to be effective not only in some cases where bypass is possible but also in many cases where it is impossible because of a poor run-off, lack of a suitable vein, or even when a bypass has failed. In a consecutively treated group of 34 patients operative reconstruction was limited to the deep femoral artery and a success rate of 65% was achieved. Most gratifying was the saving of a leg in eight patients in whom bypass was impossible.


Sickle-cell anaemia.

Sickle-cell anaemia.


Treatment of malaria.

Treatment of malaria.


Clara Stewart.

Clara Stewart.


N.S. Narasimhan.

N.S. Narasimhan.


P.L.F. Mortimer.

P.L.F. Mortimer.


P. McEwan.

P. McEwan.


C.D. Meadowcroft.

C.D. Meadowcroft.


A method of recording and analysing intention tremor.


Review of human renal transplantation at the Toronto General Hospital.


Frederick G. Kergin.

Frederick G. Kergin.


Human heart transplantation.

Human heart transplantation.


Relation of bronchial arterial circulation, and other factors, to the transient defect in oxygen uptake following autotransplantation of the canine lung.


Preferential effect of dichlorvos (Vapona) on bacteria deficient in DNA polymerase.


Immunoprophylaxis of methylcholanthrene-induced tumors in mice with Bacillus Calmette-Guérin and methanol-extracted residue.


Immunity to viral leukemia in rats and the routes of transmission from mother to offspring.


Evaluation of a micromethod for determination of antibiotic concentrations in plasma.


Ultrastructural studies of treponemes: location of axial filaments and some dimensions of Treponema pallidum (Nichols strain), Treponema denticola, and Treponema reiteri. Ultrathin sections of Treponema pallidum (Nichols strain), T. denticola (microdentium), and T. reiteri have been studied in the electron microscope to determine the location of the axial filaments and some of the dimensions of these organisms. The axial filaments of T. pallidum (Nichols strain) have been seen to be tubular in cross section with an overall diameter of 21.0 +/- 0.73 nm, and an electron-lucent core of 8.0 nm. The filaments were found to lie on the outside of the organism which had only one membranous structure surrounding the protoplasmic core. These findings were in contrast to those obtained for T. denticola and T. reiteri where the axial filaments did not exhibit a hollow core and were located between an outer membrane and an inner membrane surrounding the protoplasmic core. The outside diameter of T. denticola was determined to be 224.9 +/- 2.83 nm, and that of T. reiteri as 331.0 +/- 4.15 nm, contrasting with T. pallidum (Nichols strain) which had a diameter of 163.0 +/- 1.9 nm.


Effect of human adenoviruses on the response of chickens to sheep erythrocytes. Human adenovirus types 6, 8, and 12 were immunosuppressive in chickens. A single intravenous injection of adenoviruses markedly depressed the 19S hemolytic plaque-forming cell response in the spleen to the immunization with sheep red blood cells. Hemagglutinin production was also decreased in adenovirus type 6-infected chickens. Adenoviruses caused a transient immunosuppression in chickens which could be detected 2 to 3 days after the virus infection, and no depressive effect was found 16 to 20 days after virus injection. The possible mechanism of immunosuppression observed is discussed.


Radiobacteriolysis: a new technique using chromium-51 for assaying anti-Vibrio cholerae antibodies. A new method for detecting and quantitating antibodies against Vibrio cholerae is described. The reaction involves the release of radiochromium from prelabeled vibrios in the presence of specific antibody and complement. The entire assay can be completed within 5 hr. The method is highly reproducible, immunologically specific, temperature- and complement-dependent, and significantly more sensitive than other methods currently used for titration of anti-Vibrio cholerae antibodies. The technique is also potentially applicable to titration of antibodies against other gram-negative bacteria.


Early response of mouse foot pads to Mycobacterium laprae. The purpose of these experiments was to study the early response of mouse foot pads to Mycobacterium leprae. To accomplish this, mice were inoculated in both foot pads with large and small numbers of organisms. The animals were sacrificed at intervals from 2 hr to 27 days after inoculation. The microscopical results, which utilized normal BALB/c and thymectomized-irradiated B6C3F(1) mice, showed that the tissue responded first with an influx of polymorphonuclear cells and later lymphocytes and monocytes. The latter formed a diffuse infiltrate in the tissues. Under conditions where growth normally occurred, the mononuclear cell infiltrate did not persist. The organisms were found within phagocytic cells and the interstitial space. They were always contained within a phagosome and often fused with lysosomes. Most of the organisms appeared to be degenerating at all of the times studied. No organisms were observed in striated muscle fibers of tissues studied.


Some aspects of protein metabolism of the neuron.


Growth inhibitors and promoters acting on mycobacterium leprae.


Mixed cryoglobulinemia with a monoclonal IgM component, associated with chronic liver disease.


Mathematical identification of brain states applied to classification of drugs.


Regulation of bacteriophage T4 gene expression.


Kaposi's sarcoma in association with immunosuppressive therapy. Report of two cases.


T4 phage and T4 ghosts inhibit f2 phage replication by different mechanisms.


Diversity of regulation of genetic transcription. I. Effect of antibiotics which inhibit the process of translation on RNA metabolism in Escherichia coli.


Genetic control of DNA initiation in Escherichia coli.


Continuous synthesis of partially derepressed aspartate transcarbamylase during the division cycle of Escherichia coli B-r.


Doxycycline treatment of chronic trachoma.


Serial sections of the jaw of a ferret.

Serial sections of the jaw of a ferret.


Low cost multichannel scanning pH-stat.

Low cost multichannel scanning pH-stat.


Suppression of rabbit ear skin homograft rejections with sheep anti-thymus globulins. A preliminary report.


The George Howell Coleman Medal of the Institute of Medicine of Chicago.


Man's surroundings and his health.

Man's surroundings and his health.


The achievement of Duchenne.

The achievement of Duchenne.


Lettsom and his family in Tortola.

Lettsom and his family in Tortola.


The generative gap or why didn't they do something about it?


Dr. William Henry Cook: the finances of a Victorian general practitioner.


Is halothane hepatotoxicity an allergic reaction to halothane?


Man the hunter.

Man the hunter.


Halothane hepatitis--fact or fallacy?

Halothane hepatitis--fact or fallacy?


Antibacterial therapy in childhood.

Antibacterial therapy in childhood.


In memoriam: Josse Kaye.

In memoriam: Josse Kaye.


Endoscopic suspension of the vesical neck for urinary incontinence.


Everting anastomoses in the biliary tract.


Permanent nephrostomy by cutaneous inversion.


Exogenous glucose as an energy substrate in experimental hemorrhagic shock.


Amos Barber, Charles Penrose, and the war on Powder River.


Healing processes in skin grafts.

Healing processes in skin grafts.


Enrique and Ricardo Finochietto: surgery, the ultimate devotion.


Orthotopic cardiac allografts in presensitized canine recipients.


Technique for treating stricture at a ureteroneocystostomy.


A new antibody, anti-K12, associated with the Kell blood group system.


Observations on a new example of the A m  phenotype which demonstrates reduced A secretion.


Specific developmental dyslexia and word blindness.


Hydrolysis of obidoxime chloride (Toxogonin). 3. Kinetics in neutral and alkaline solution.


Hydrolysis of some pyridinium aldoximes. VI. Hydrolysis of bis(2-hydroxyiminomethyl-1-pyridiniomethyl)-ether dichloride and 2,4'-bis(hydroxyiminomethyl)-bis(1-pyridiniomethyl) ether dichloride.


Pulmonary insufficiency after nonthoracic trauma: shock lung.


Comparative evaluation of Avitene microcrystalline collagen hemostat in experimental animal wounds.


Orthotopic liver allografts in the pig.

Orthotopic liver allografts in the pig.


An auto-suture instrument. Preliminary report.


On the antigenic relationship of "Vibrio cholerae" to "Enterobacteriaceae".


Long term storage of Vibrio fetus cultures by means of freeze-drying.


The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by yeast glucose 6-phosphate dehydrogenase.


Nitrogenase of Klebsiella pneumoniae: interaction with viologen dyes as measured by acetylene reduction.


The deoxyfluoro-D-glucopyranose 6-phosphates and their effect on yeast glucose phosphate isomerase.


Isolation of a zinc protein from the tapetum lucidum of the cat.


Endotoxins in a lipopolysaccharide preparation and cell envelope of Escherichia coli.


Preparation of gram quantities of a purified R-factor-mediated penicillinase from Escherichia coli strain W3310. Purified penicillinase, in gram quantities, has been prepared from Escherichia coli strain W3310 by using methods developed to handle large amounts of material. The final product had a specific enzyme activity of 3.08 units/mug of protein, which was over twice as high as that reported previously (Datta & Richmond, 1966). The purified enzyme was similar to that from E. coli strain TEM, but different in molecular weight and some other respects. The differences observed may be a result of the greater purity obtained.


Lipoamide dehydrogenase mutants of Escherichia coli K 12.


Reaction of normal human lymphocytes and chronic lymphocytic leukemia cells with an antithymocyte antiserum.


Urinary fistulae after renal transplantation.


Utilization of L-glutamine in intercellular adhesion: ascites tumor and embryonic cells.


Cell cultures of fetal rat brain: growth and marker enzyme development.


Behavior of cultured cells on substrata of variable adhesiveness.


Nucleolar morphology and cell proliferation kinetics of thymic lymphocytes.


Macrophage spreading in vitro. I. Inducers of spreading.


Doubling potential, calendar time, and senescence of human diploid cells in culture.


Countercurrent distribution and multiple sedimentation of Chlorella pyrenoidosa during its life cycle.


Cell interactions and histogenesis in embryonic neural aggregates.


Growth inhibition of mouse lymphoma cells, L5178Y, in vitro, by glucocorticoids: alterations in choline metabolism.


Regulatory mechanism of cell division. I. Colchicine-induced endoreduplication.


Interallelic complementation in hybrid cells derived from Chinese hamster diploid clones deficient in hypoxanthine-guanine phosphoribosyl-transferase activity.


Statistical trends in utilization review in extended care facilities. After 3 years of Medicare.


Use of dental services in an urban area before Medicaid and an OEO health center.


Increased levels of plasma insulin and eleven hydroxycorticosteroid induced by sucrose, and their reduction by phenformin.


Presidential address: Indian Society of Nephrology, Jan. 1972.


Leucine accumulation by isoleucine revertants of Serratia marcescens resistant to  -aminobutyric acid: lack of both feedback inhibition and repression.


Isolation and characterization of  -D-mannosidase from baker's yeast.


The number and size of ribosomal proteins in the cellular slime mold Dictyostelium discoideum.


R17 RNA replicase. IV. Rifamycin sensitive component of the replicase.


Disaggregation of connective tissue: preparation of fibrous components from sea cucumber body wall and calf skin.


States of imino groups in pepsin measured by the reactivity with tertiary-butylhypochlorite.


The structure and function of acid proteases. Specific inactivation of an acid protease from Rhizopus chinensis by diazoacetyl-DL-norleucine methyl ester.


Chemical and physicochemical characterization of potato proteinase inhibitor I and comparison of its specificity with those of inhibitors II-a and II-b.


Isolation of a factor, from the capsule of a granulosis virus, synergistic for a nuclear-polyhedrosis virus of the armyworm.


Structure of bacteriophage T4 genes 37 and 38.


Binding of complementary pentanucleotides to the anticodon loop of transfer RNA.


On the rate of messenger decay during amino acid starvation.


Effect of conditioning the enamel surface with phosphoric acid.


Specific recognition of non-initiator regions in RNA bacteriophage messengers by ribosomes of Bacillus stearothermophilus.


Lysis of certain organisms by the synergistic action of complement and lysozyme.


Anxiety states (anxiety neurosis): a review.


Distribution of suboptimally induces  -D-galactosidase in Escherichia coli. The enzyme content of individual cells.


Studies on the murine leprosy bacillus. V. Growth in relation to concentrations of monopotassium phosphate, sodium glutamate, and glycerol in the 1 per cent egg yolk medium, and relation to pH of the medium.


Changes of serum antibodies of patients, carriers and healthy persons during a dysentery outbreak.


3-O-Methyldopa, L-dopa, and trihexyphenidyl in the treatment of Parkinson's disease.


"Readers of the skin," 1572-1816.

"Readers of the skin," 1572-1816.


A history and physical on itching.

A history and physical on itching.


Bruce Hunt memorial oration--1969.

Bruce Hunt memorial oration--1969.


Limb loss and limb replacement: a new confidence.


Treatment and prevention of stroke. I. Subarachnoid hemorrhage due to ruptured intracranial aneurysm.


The use of a compartmental hypothesis for the estimation of cardiac output from dye-dilution curves and the analysis of radiocardiograms.


Self-control of cardiac functioning: a promise as yet unfulfilled.


Self- and interpersonal evaluations: esteem theories versus consistency theories.


Cognitive factors in electrodermal conditioning.


Comment on the distinction between hazard and safety in evaluation of human health hazards on use of dichlorvos, especially in resin strips.


Polychlorinated biphenyls: occurrence and biological effects.


DDT residues in marine phytoplankton.

DDT residues in marine phytoplankton.


Effects of nutrition on the composition of tooth lipids and fatty acids in rats. II. Effects of restriction of a cariogenic diet on caries and lipid composition of molars and incisors.


Continuous studies of the enamel subsurface areas of teeth: three in vitro techniques.


Lytton Strachey and the masochistic basis of homosexuality.


Geoffrey Dix English.

Geoffrey Dix English.


The possible importance of transfer factors in the bacterial degradation of herbicides in natural ecosystems.


Guidelines for environmental study of pesticides: determination of bioconcentration potential.


An approach to the extensively injured hand.


Recent trends in protein methodology.

Recent trends in protein methodology.


Magnesium and its significance in cardiovascular and gastro-intestinal disorders.


The biological regulation of copper homeostasis in the rat.


Nutrition in Taiwan, the Republic of China. Progress, problems, and planning.


Nutrition education research.

Nutrition education research.


Water-borne goitrogens and their role in the etiology of endemic goiter.


Cleft lip and cleft palate: research relevant to clinical management in dentistry. An NIDR State of the Art report. Subcommittee on Dentistry.


American Thoracic Society. Medical Section of the National Tuberculosis and Respiratory Disease Association.


Therapeutic trials in renal disease.

Therapeutic trials in renal disease.


Fractured sternum with flail chest and posttraumatic pulmonary insufficiency syndrome. Report of 4 patients.


Development of insulin secretion in the human fetus.


Factors affecting the form of medullocervical dislocation deformity in relation to meningomyelocele and spina bifida.


Quantitative study of vesical ganglia in children with neurospinal dysraphism.


Residual bodies and their components. I. Isolatin methods.


Evidence for neural sites of action of phenobarbital and progesterone on LH release in the hamster.


Pathology of infective endocarditis. A postmortem evaluation.


Incidence of cardiac malformations at birth and later, and neonatal mortality.


Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans).


The coronary drug project. Design, methods, and baseline results.


Acute effects of clonidine on central and peripheral haemodynamics and plasma renin activity.


New indications for 6-azauridine treatment in man. A review.


Cardiovascular causes of sudden death in "De Subitaneis Mortibus" by Giovanni Maria Lancisi. A translation from the original latin.


Tularemia: Dr. Edward Francis and his first 23 isolates of Francisella tularensis.


A rural medical practitioner in fifteenth-century England.


Richard Harrison Shryock, 1893-1972.

Richard Harrison Shryock, 1893-1972.


An eighteenth-century remedy book: a preliminary note.


Use of fluorescein conjugated dextran for the detection of MOPC 104E tumor cells.


The occurrence of vesicoureteral reflux and pyelonephritis in apparently normal dogs.


An investigation of the relationship of nonspecific urethritis corynebacteria to the other microorganisms found in the urogenital tract by means of a modified chocolate agar medium.


Purification and characterization of adenylate kinase as an apparent adenosine triphosphate-dependent inhibitor of ribonuclease II in Escherichia coli.


Acetyl coenzyme A carboxylase. Proteolytic modification of biotin carboxyl carrier protein.


Purification and properties of purine nucleoside phosphorylase from Salmonella typhimurium.


Catalytic reactions of phosphoglucose isomerase with cyclic forms of glucose 6-phosphate and fructose 6-phosphate.


Affinity labeling of phosphoglucose isomerase by 1,2-anhydrohexitol-6-phosphates.


Mannose 6-phosphate: anomeric form used by phosphomannose isomerase and its 1-epimerization by phosphoglucose isomerase.


Colicine production as an epidemiological marker of Escherichia coli.


Characterization of T7-specific ribonucleic acid polymerase. 1. General properties of the enzymatic reaction and the template specificity of the enzyme.


Joint trimethoprim and sulphamethoxazole resistance in bacteria infected with R factors.


The relationship between interferon and virus virulence in influenza virus infections of the mouse.


The motion of the swarm in Proteus mirabilis.


Antigen-induced depression of antigen-reactive cells in immunised mice.


Treatment of experimental L-phase infections of the urinary tract.


Carbamazepine for painful crises in Fabry's disease.


Intraoral transplants of cancellous bone and marrow in periodontal lesions.


A surgical investigation of the clinical physiology of the LP-pulvinar complex in man.


The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of theophylline and epinephrine on Ca efflux from perifused islets.


Glucose metabolism by rat pancreatic eslets in vitro.


Post-fertilization synthesis of polyadenylic acid in sea urchin embryos.


Protease activity establishes the block against polyspermy in sea urchin eggs.


Sexual differences in human crowd motion.


Organochlorine levels in Atlantic seabirds.


Magnetic implants in good lower ridges to prevent absorption of the mandibular ridges.


Effect of auxiliary acoustic stimulation on two-flash fusion thresholds of reading disabled children: a study using nitrazepam.


Simple electrode for making subcortical electrolytic lesions with the Baltimore Rat Stereotaxic Instrument.


Laxatives in the treatment of constipation in pregnant and breast-feeding mothers.


Caring for children with cystic fibrosis.


An analgesic combination.

An analgesic combination.


Double-blind trial of diazepam in rheumatoid arthritis.


Carbamide in hyperkeratosis.

Carbamide in hyperkeratosis.


'The Aesculapius of our age': William Butler, M.A. (1535-1618).


Still's disease. George Frederick Still (1868-1941).


In memoriam: William Waks.

In memoriam: William Waks.


Undesirable properties of rubella vaccines with special reference to their use in women of fertile age.


Geriatrics.

Geriatrics.


The detective was a doctor.

The detective was a doctor.


Severe rejection of an HL-A identical sibling renal transplant.


Diagnosis and management of intestinal obstruction.


Gastric dilatation and the gastric torsion complex.


Surgery of the rectum and anus.

Surgery of the rectum and anus.


Surgery of the canine esophagus.

Surgery of the canine esophagus.


Gastrointestinal parasitism in the dog.

Gastrointestinal parasitism in the dog.


Peritonitis.

Peritonitis.


Interpreting problem diarrheas of dogs.

Interpreting problem diarrheas of dogs.


Surgery of the pharynx.

Surgery of the pharynx.


Nutritional management in gastrointestinal disorders.


Pancreatitis in dogs.

Pancreatitis in dogs.


Esophagoscopy.

Esophagoscopy.


Experimental pyelonephritis. 18. Pseudomonas aeruginosa and E. coli prostatic infection in the rat and the effects of water diuresis.


Surgical correction of transposition of the great vessels. Technical considerations.


Control of proximal subclavian arterial injury with internal shunt catheter.


Tracheobronchial reconstruction.

Tracheobronchial reconstruction.


For their love of Carrie.

For their love of Carrie.


The binaural stethoscope.

The binaural stethoscope.


Computer discrimination of cells in serous effusions. I. Pleural fluids.


On the defect of a dCMP hydroxymethylase mutant of bacteriophage T4 showing enzyme activity in extracts.


Synthesis and coding properties of poly(c 1 A), poly(c 3 A), poly(c 7 A) and poly(h 6 A).


Thrombin cell block technic in gynecologic cytodiagnosis.


Terminal oxidation-reduction of yeast phenylalanine tRNA prevents donor and acceptor function at the peptidyl transferase center.


Sir Charles Harington (1897-1972).

Sir Charles Harington (1897-1972).


Peptide utilization in yeast. Studies on methionine and lysine auxotrophs of Saccharomyces cerevisiae.


Deductive analysis of a protein-synthesis mutant of Escherichia coli.


The rate of reparative dentin formation in the human deciduous teeth.


A review of the development of the health services of Rhodesia from 1923 to the present day.


Pulmonary nocardiosis complicating malignant lymphoma successfully treated with chemotherapy.


Auscultatorily silent patent ductus arteriosus. Report of two cases with normal pulmonary pressures.


Felt pledgets in cardiovascular surgery.


Effects of temperature and substrate concentration on the LDH- -HBD ratio in heart and liver disease.


Interferons and host resistance: with particular emphasis on induction by complexed polynucleotides.


Enzyme reaction stereospecificity: a critical review.


Properties of proinsulin and related polypeptides.


DNA repair synthesis in human heterokaryons formed by normal and UV-sensitive fibroblasts.


Thermal solubilization of the trichocysts from Paramecium aurelia.


Electronmicroscope investigations of the underside of cells in culture.


Fluorescence and light-scattering measurements on hog cholera-infected PK-15 cells.


A simple method for estimation of cell cycle parameters.


Early contacts between fibroblasts. An ultrastructural study.


Morphology and ultrastructure of staphylococcal L colonies: light, scanning, and transmission electron microscopy. Scanning electron microscopy utilizing critical point drying was used in parallel with light and transmission electron microscopy to study L colonies produced by a stable L-phase variant of Staphylococcus aureus (AH24H).


Molecular structure of an R factor, its component drug-resistance determinants and transfer factor. Plasmid DNA from Escherichia coli strains harboring drug resistance either of the infectious or noninfectious kind has been separated by CsCl centrifugation of crude cell lysates in the presence of ethidium bromide and examined by electron microscopy. Plasmid deoxyribonucleic acid (DNA) from an S(+) strain (which has the property of noninfectious streptomycin-sulfonamide resistance) consists of a monomolecular covalently closed circular species of 2.7 mum in contour length (5.6 x 10(6) atomic mass units; amu). DNA from a strain carrying a transfer factor, termed Delta, but no determinant for drug resistance, is a monomolecular covalently closed circular species of 29.3 mum in contour length (61 x 10(6) amu). DNA from either Delta(+)A(+) or Delta(+)S(+) strains, (which are respectively ampicillin or streptomycin-sulfonamide resistant, and can transfer this drug resistance), shows a bimodal distribution of molecules of contour lengths 2.7 mum and 29.3 mum, whereas DNA from a (Delta-T)(+) strain (showing infectious tetracycline resistance) contains only one species of molecule measuring 32.3 mum (67 x 10(6) amu). We conclude that ampicillin resistance is carried by a DNA molecule (the A determinant) of 2.7 mum, and streptomycin-sulfonamide resistance is carried by an independent molecule (the S determinant) of similar size. These molecules are not able to effect their own transfer, but can be transmitted to other cells due to the simultaneous presence of the transfer factor, Delta, which also constitutes an independent molecule, of size 29.3 mum. In general, there appears to be little recombination or integration of the A or S molecules into that of Delta, although a small proportion (5-10%) of recombinant molecules cannot be excluded. In contrast, the third drug-resistance determinant, that for tetracycline resistance (denoted as T), is integrated in the Delta molecule to form the composite structure Delta-T of size 32.3 mum, which determines infectious tetracycline resistance. The Delta(+)A(+) and Delta(+)S(+) strains are defined as harboring plasmid aggregates, and the (Delta-T)(+) strain is defined as carrying a plasmid cointegrate; the properties of all three strains are characteristic of strains harboring R factors. These results are compatible with the previously published genetic data. The number of Delta molecules per cell appears to be equal to the chromosomal number irrespective of growth phase, and this plasmid can thus be defined as stringently regulated in DNA replication. In contrast, S and A exist as multiple copies, probably in at least a 10-fold excess of chromosomal copy number. S and A can thus be defined as relaxed in the regulation of their DNA replication.


Ascospore wall development in Saccharomyces cerevisiae. Ascospore delimitation in Saccharomyces cerevisiae is initiated by a pair of unit membranes between which the spore wall is subsequently laid down.


Identification of a self-inhibitor from spores of Dictyostelium discoideum. A self-inhibitor of spore germination has been isolated from spores of Dictyostelium discoideum, a cellular slime mold, and chemically characterized as 2-dimethylamino-6-oxypurineriboside.


Initiation and termination of bacterial deoxyribonucleic acid replication in low concentrations of chloramphenicol. Escherichia coli 15T(-) can initiate a cycle of deoxyribonucleic acid replication with equal efficiency in the presence of 25 or 50 mug of chloramphenicol/ml. However, these replication cycles are not completed in the presence of these drug concentrations, and the amount of replication decreases with increasing drug concentration.


Genetic control of "flor" formation by Saccharomyces. The results described indicate that in Saccharomyces sp. the formation of "flor" is under the control of a single Mendelian gene for which is proposed the symbol "Fl."


Surface distributon of invertase on growing Saccharomyces cells. By using fluorescein-labeled antibodies, we found that most of the newly formed invertase molecules at the surface of a Saccharomyces cell surround the developing bud.


Lack of specificity of renal angiography in the diagnosis of renal parenchymal disease. A point of view.


Screening procedure for Escherichia coli mutants deficient in ribonuclease I. Strains of Escherichia coli that possess ribonucleic acid accumulated under relaxed growth conditions show a considerable increase in time before the onset of beta-galactosidase inducibility. This time dependency can be related to the presence or absence of ribonuclease I.


Preliminary mapping of mutations affecting exonuclease 3 in Escherichia coli K-12. xthA, a structural gene for exonuclease III in Escherichia coli K-12, is cotransducible with aroD, aroH, and pps.


Formation of catenated colicin factor E1 deoxyribonucleic acid molecules in a recombination-deficient strain of Escherichia coli. Catenated deoxyribonucleic acid molecules of colicin factor E1 (Col E1) were found with nearly equal frequency in minicells derived from Escherichia coli strain P678-54 recA(+) (Col E1) and P678-54 recA(-) (Col E1). The result suggests that the recombination function controlled by the recA gene does not influence the formation of catenated Col E1.


Facilitated diffusion of monosaccharides in Saccharomyces cerevisiae: experimental investigation of kinetic parameters without the assumptions of symmetry. Until the question of symmetry or asymmetry in the facilitated diffusion of monosaccharides by Saccharomyces cerevisiae is resolved, attempts to study the transport process cannot be based on assumptions of symmetry, such as equal concentrations at equilibrium or kinetic parameters that are equal in opposite directions. The assumptions of symmetry may be circumvented by measuring efflux against water and against various external concentrations of sugar. The measurement of efflux against water eliminates any involvement of influx, and the separate determinations of influx and efflux parameters do not require that the parameters be equal. Furthermore, the use of relative internal concentrations eliminates any necessity of assuming that the equilibrium concentrations are equal. Since the influx and efflux parameters are to be compared, the measurement of influx on effluxing cells allows both sets of parameters to be determined on cells which are physiologically the same. This procedure has been tested by obtaining the kinetic parameters of l-sorbose transport. The validity of these parameters was demonstrated by using them to generate theoretical efflux curves that fit the experimental data and by showing that they give the best fit curve to the relationship of velocity and permeant concentration. Although the question of symmetry remains unanswered, this procedure has opened the way for experimental evaluation of the situation and further investigation of the transport process in yeast.


Inorganic phosphate transport in Escherichia coli: involvement of two genes which play a role in alkaline phosphatase regulation. Two classes of alkaline phosphatase constitutive mutations which comprise the original phoS locus (genes phoS and phoT) on the Escherichia coli genome have been implicated in the regulation of alkaline phosphatase synthesis. When these mutations were introduced into a strain dependent on a single system, the pst system, for inorganic phosphate (P(i)) transport, profound changes in P(i) transport were observed. The phoT mutations led to a complete P(i) (-) phenotype in this background, and no activity of the pst system could be detected. The introduction of the phoS mutations changed the specificity of the pst system so that arsenate became growth inhibitory. Changes in the phosphate source led to changes in the levels of constitutive alkaline phosphatase synthesis found in phoS and phoT mutants. When glucose-6-phosphate or l-alpha-glycerophosphate was supplied as the sole source of phosphate, phoT mutants showed a 3- to 15- fold reduction in constitutive alkaline phosphatase synthesis when compared to the maximal levels found in limiting P(i) media. However, these levels were still 100 times greater than the basal level of alkaline phosphatase synthesized in wild-type strains under these conditions. The phoS mutants showed only a two- to threefold reduction when grown with organic phosphate sources. The properties of the phoT mutants selected on the basis of constitutive alkaline phosphatase synthesis were similar in many respects to those of pst mutants selected for resistance to growth inhibition caused by arsenate. It is suggested that the phoS and phoT genes are primarily involved in P(i) transport and, as a result of this function, play a role in the regulation of alkaline phosphatase synthesis.


Acyl carrier protein in mycoplasmas.

Acyl carrier protein in mycoplasmas. Acyl carrier protein (ACP) activity was determined by the malonyl-coenzyme A-CO(2) exchange reaction. It was highest in Acholeplasma laidlawii, lower in A. granularum, and lowest in A. axanthum. The sterol-requiring Mycoplasma species examined showed little or negligible ACP activity. A. laidlawii was capable of utilizing pantetheine or coenzyme A but not beta-alanine as precursor for ACP synthesis. Its ACP could thus be labeled by growing the organisms with radioactive coenzyme A. The ACP of A. laidlawii appears to be a soluble cytoplasmic protein, which could be purified about 40-fold by treatment of the cytoplasmic fluid with streptomycin sulfate and chromatography of the supernatant fluid on a Biogel P-10 column. Its molecular weight, determined by polyacrylamide gel electrophoresis, is low (about 10,900) resembling that of Escherichia coli, but it is much more sensitive to heat.