Transduction of R factors in Proteus mirabilis and P. rettgeri.


Morphological phases in the swarm of Bacillus licheniformis.


Independent expression of the A gene of the tryptophan operon of Escherichia coli during tryptophan starvation.


Ultraviolet sensitivity, spontaneous mutability and DNA degradation in Escherichia coli strains carrying mutations in uvr and rec genes.


Anaerobic R factor transfer in Escherichia coli.


The sensitivity of suppressed and unsuppressed lon strains of Escherichia coli to chemical agents which induce filamentation.


Effect of mild heating on Salmonella typhimurium containing an R factor.


Modifications to the phospholipid composition of Saccharomyces cerevisiae induced by exogenous ethanolamine.


Selection of R- and S-phase colonies from dimorphic Alcaligenes odorans var. viridans, and their isolation in pure culture.


Role of diagnostic aspiration of peritoneal fluid in acute abdominal conditions.


Comparison of the responses of Escherichia coli and proteus mirabilis to seven beta-lactam antibodies.


Studies of the local immune response to pyelonephritis in the rabbit.


In vivo antagonism between gentamicin and chloramphenicol in neutropenic mice.


Influence of furosemide diuresis on antimicrobial treatment of pyelonephritis due to Escherichia coli.


Behavioral motivation.

Behavioral motivation.


Smoker's wrinkles?

Smoker's wrinkles?


Effect of BCG on carcinogen-induced tumor development in mice.


Mechanism of action of colicin E2.

Mechanism of action of colicin E2.


The bone marrow reaction caused by endotoxin. A relation between changes of cellularity in bone marrow and peripheral blood, and measurement of in vivo cytotoxicity.


Studies on endotoxin-like substances in Yoshida sarcoma cells.


Further characterization of long-liver proteins in mouse tissues.


Neuronal activity evoked in nucleus medialis dorsalis of the thalamus after stimulation of the amygdala.


Stereotaxic surgical techniques for the mouse.


Heart rate conditioning of anosmic rats.


James Alexander Frederick Stevenson (1918-1971).


Effect of lesions in the amygdala on behavioral contrast.


Habituation of the pyramidal response in unanesthetized cat.


Effects of olfactory bulb removal on aggression: a reevaluation.


Modification of behavioral estrus in the guinea pig following intracranial cycloheximide.


Hyperirritability, lever-press avoidance, and septal lesions in the albino rat.


Cortical projections of ascending nonspecific systems.


Intraspecific fighting in albino mice with septal forebrain lesions.


Persistent depression of wood-gnawing following ventromedial hypothalamic lesions in the rat.


The corrective treatment of the skeletal asymmetry in hemifacial microsomia.


Our present technique for rhytidectomy.

Our present technique for rhytidectomy.


Simon P. Hullihen: pioneer oral and plastic surgeon.


Distant transfer of cutaneous island flaps in humans by microvascular anastomoses.


Performance analysis of imaging systems.


Radionuclide tomography.

Radionuclide tomography.


Physiological role of prostaglandins in the induction of ovulation.


The effects of some bacterial toxins on placental transport in the rabbit.


Properties of the skin as a membrane.

Properties of the skin as a membrane.


The action of local anesthetics.

The action of local anesthetics.


Cutaneous blood flow and tissue blood exchange.


Some practical applications of percutaneous absorption theory.


Percutaneous absorption.

Percutaneous absorption.


Stratum corneum reservoir for drugs.

Stratum corneum reservoir for drugs.


Models of membrane architecture.

Models of membrane architecture.


Drug interactions.

Drug interactions.


Neural regulation of cutaneous circulation.


The action of antimetabolites in the skin: methotrexate for psoriasis.


Antifungal agents.

Antifungal agents.


The use of antibiotics in dermatology.

The use of antibiotics in dermatology.


Penetration and action of glucocorticoids.


Factors influencing the penetration of corticosteroids through the epidermis.


Slit-scan cytofluorometry.

Slit-scan cytofluorometry.


Biotransformation of steroids by the skin.


A cytologic study of amniotic fluid.

A cytologic study of amniotic fluid.


Alterations in sweat gland function produced by pharmacological agents.


Diffusion of drugs from topical vehicles: an analysis of vehicle effects.


Computer recognition of cell nuclei from the uterine cervix.


Drug-protein interactions and their clinical significance.


The effects of various vehicles on absorption rates in skin.


Some bioassay methods for measuring percutaneous absorption.


Protein binding.

Protein binding.


The binding properties of melanin: in vivo and in vitro.


Drug metabolism.

Drug metabolism.


Genetic determimants in drug action.

Genetic determimants in drug action.


Ivemark syndrome with aortic atresia.

Ivemark syndrome with aortic atresia.


Pulmonary interstitial emphysema with gas embolism in hyaline membrane disease.


Femoro-cerebral angiography: analysis of 2,000 consecutive examinations, special emphasis on carotid arteries catheterization in older patients.


Anticipating changes in neuroradiology.

Anticipating changes in neuroradiology.


Myelographic characteristics of metastasis to the spinal cord and cauda equina.


The ceremonial mace of the American College of Radiology.


[Bergson and dreams].

[Bergson and dreams].


The Malumfashi pilot survey. I. Introduction, malaria and urinary schistosomiasis.


Rifampicin limitation of DNA synthesis in ultraviolet-damaged bacteria: evidence for postirradiation replication synchrony.


An investigation into the role of malonyl-coenzyme A in isoprenoid biosynthesis. 1. [(14)C]Malonyl-CoA was incorporated into isoprenoids by cell-free yeast preparations, by preparations from pigeon and rat liver, and by Hevea brasiliensis latex. 2. In agreement with previous reports the incorporation of acetyl-CoA into isoprenoids was not inhibited by avidin and was not stimulated by HCO(3) (-). In a cell-free yeast preparation addition of HCO(3) (-) stimulated the formation of fatty acids from acetyl-CoA and decreased the incorporation into unsaponifiable lipids. 3. The labelling patterns of beta-hydroxy-beta-methylglutaryl-CoA formed from [2-(14)C]- and [1,3-(14)C]-malonyl-CoA in rat and pigeon liver preparations were those that would be expected if malonyl-CoA underwent decarboxylation to acetyl-CoA before incorporation. 4. The labelling pattern of ergosterol formed by cell-free yeast preparations from [2-(14)C]malonyl-CoA was also consistent with decarboxylation of malonyl-CoA before incorporation. 5. The incorporation of [2-(14)C]malonyl-CoA into mevalonate by rat liver preparations was related to the malonyl-CoA decarboxylase activity present in the preparation.


Isoaccepting species of histidine-specific transfer RNAs from baker's yeast: purification and properties.


Secondary structure of RNA phage M12 replicative intermediates in vivo.


Raman studies of nucleic acids. 8. Estimation of RNA secondary structure from Raman scattering by phosphate-group vibrations.


Inhibition of RNA synthesis in mitochondria by daunomycin.


Mitochondrial antibiotic resistance in yeast: ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin.


Thermal stability of phosphoribosyladenosine triphosphate synthetase as reflected in its circular dichroism and activity properties. Effect of inhibitors.


The trichodermin group of antibiotics, inhibitors of peptide bond formation by eukaryotic ribosomes.


The death of the artist's father:  Henrik Ibsen.


Obituary. Edward Glover.

Obituary. Edward Glover.


Hypothalamic LH and FSH releasing hormone; physiological and clinical studies.


The inhibition by carbenoxolone sodium of individual human pepsinogens and pepsins.


Development of clinical cardiology in the USSR.


Cyclic kinetics and mathematical expression of the primary immune response to soluble antigen. I. Cyclic kinetics of immunogenesis.


Biological behaviour of reticulum cell neoplasm type A originating in the uterus of female ICRC mouse treated with progesterone.


The effect of actinomycin D and flavomycin on Escherichia coli R+ strains.


Distribution pattern of streptomycetes from flooded Ganges water.


The economics of arthritis.

The economics of arthritis.


Esophageal graft protection with intact omentum.


Factors affecting mortality of patients with bacteremia.


The anatomy and repair of the posterior inguinal wall.


Technique for the secure suture of rubber tubes.


Area of the organic-inorganic interface of dental enamel.


Oxygen toxicity.

Oxygen toxicity.


Early days in the first American training school for nurses.


Separation of spleen colony forming units (CEU-S) from mouse bone marrow cells using velocity sedimentation in an isokinetic gradient of Ficoll in tissue culture medium. Spleen colony forming cells (CFU-S) from mouse bone marrow were concentrated using velocity sedimentation in an isokinetic gradient of Ficoll (polysucrose) in tissue culture medium. Following separation, CFU-S were found as a sharp modal population of cells which was discrete from the modal populations of lymphocytes and other cell types. Despite the wide separation of lymphocytes, granulocytes and CFU-S in the density gradient, there was no appreciable resolution of CFU-S specifically committed to erythroid, granulocytic or undifferentiated colony formation. This suggests that committed stem cells either share identical physical properties or are not detected by the spleen colony assay. In the purest fractions from the isokinetic gradient, CFU-S were 2.8- to 4.7-fold purified when compared with mouse bone marrow before separation.


Metabolic and chemical features of ferritins, a series of iron-inducible tissue proteins.


Iron kinetics with emphasis on iron overload.


The relationship of intracellular pathways of iron metabolism to cellular iron overload and the iron storage diseases. Cell sap and cytocavitary network pathways in relation to lysosomal storage and turnover of iron macromolecules.


Hemodynamics of innominate artery occlusion.


High abdominal aortic aneurysm, hepatic artery aneurysm, and cystadenoma of pancreas treated surgically in a young woman.


Surgical management of the dialysis patient.


Possible association between triphasic E.E.G. waves and disorder of dopaminergic systems. In a patient probably suffering from Jakob-Creutzfeldt disease of the Jones-Nevin type and in another with a cerebral infarction treatment with amantadine (Symmetrel) 100 mg twice a day caused repetitive triphasic waves to disappear from the E.E.G. in each case. In view of these findings and the fact that some other conditions in which repetitive triphasic E.E.G. waves are a clinical feature greatly improve on treatment with levodopa, the suggestion is made that these waves result from a disorder of the dopaminergic system.


Effects of parietal cell vagotomy on acid and pepsin secretion in gastric fistula dogs.


Spina bifida and potatoes.

Spina bifida and potatoes. The results of a retrospective survey of the dietetic and other habits of the mothers of 83 children with spina bifida (mostly schoolchildren with meningomyelocele) were compared with 85 carefully matched controls. The survey was particularly concerned with the consumption of or contact with potatoes by the mothers. No significant differences were found in the amount of potatoes eaten as reported by the mothers (mean for spina bifida group 3.60 1b (1630 g), and for controls 3.98 1b (1800 g) per week). Of the seven other comparisons associated with potatoes only one (obtaining them from the chip shop or restaurant) was significant, the mothers of the children with spina bifida being more likely to obtain some of them from this source.When examining other aspects of diet it was found that the mothers of spina bifida children reported a lower consumption of a number of important foods, though the deficiency was not significant in any instance. These mothers were also significantly more likely to have been prescribed drugs other than iron and vitamins early in pregnancy and to have reported a wider variety of illnesses.The results in general do not support the hypothesis that the quantity of potatoes taken is important. They do lend support to the view that poor dietary habits are associated with a higher incidence of spina bifida irrespective of social class. Furthermore, general ill health in the mother may be implicated.


Antiviral chemotherapy: the first decade.


Hepatic encephalopathy.

Hepatic encephalopathy.


Major-General Sir Edward Phillips.

Major-General Sir Edward Phillips.


The Mallory-Weiss Syndrome.

The Mallory-Weiss Syndrome.


Thermal shock and dilution shock as the causes of freezing injury.


Visualization of freezing damage. II. Structural alterations during warming.


Freeze-drying of live oral streptomycin dependent mutant Shigella vaccines: survival of streptomycin-dependent Shigella sonnei after freeze-drying.


Effect of cryostorage on oxygen uptake and autograft viability of rat skin.


Increase in incidence of reticulum cell sarcoma in F1 hybrid mice thymectomized and bearing thymus grafts from parental strain.


Fédération Dentaire Internationale Chronicle of the XVth World Dental Congress and 60th Annual Session, Mexico City, 21st-28th October 1972.


The effects of fillings and prosthetic appliances on the marginal gingiva.


Prevention in relation to restorative and prosthetic dentistry.


Local preventive measures and education in the prosthetic patient.


The structure of joints.

The structure of joints.


Medical and surgical applications of collagen.


Cryptic lysogeny in Proteus mirabilis.

Cryptic lysogeny in Proteus mirabilis.


Freeze-etched connective tissue.

Freeze-etched connective tissue.


A new dermatological preparation for treating candidiasis.


Attitudes toward the Rorschach Test expressed in book reviews: a historical perspective.


Significance of Rorschach response modified by responses to other projective tests.


Pemphigus vulgaris involving the cervix associated with endometrial carcinoma of the uterus: a case report with immunofluorescent findings.


Measuring the ability to express sexual thoughts.


A non-verbal technique for assessing frustration response in pre-school children.


The clinical evaluation of medicaid's patients in the state of New York.


Validating Hand Test Acting Out Ratios for overt and experimentally induced aggression.


Bacterial flora of infants' skin: comparison between diaper-occluded and unoccluded areas.


Annual discourse--the Boston City Hospital: a tale of three "cities".


Pediatric surgery. 2.

Pediatric surgery. 2.


Joseph Garland, M.D., 1893-1973. The man, his family and friends.


Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome.


Joseph Garland, M.D., 1893-1973. The pediatrician.


Joseph Garland, M.D., 1893-1973. The writer.


Joseph Garland, M.D., 1893-1973. The editor.


Joseph Garland, M.D., 1893-1973. Curriculum vitae.


Mental retardation as a learning disorder.


Learning disabilities.

Learning disabilities.


An historical review of multiphasic screening.


Evaluation of two contrasting types of screening programs.


A corner of history: the stethoscope.

A corner of history: the stethoscope.


An appraisal of techniques for the determination of protein turnover in vivo.


Measurement of the synthesis of liver-produced plasma proteins with special reference to their regulation by dietary protein and amino acid supply.


The pattern of protein turnover in the whole animal and the effect of dietary variations.


Ribosomal RNA synthesis and function as influenced by amino acid supply and stress.


The effect of diet on rat liver nucelar DNA-dependent RNA polymerase.


Dietary fat and cardiovascular disease: possible modes of action of linoleic acid.


Diet in the epidemiology of coronary heart disease.


Sucrose and cardiovascular disease.

Sucrose and cardiovascular disease.


The EMI-scanner: computerised transverse axial tomography--a new technique.


Modification of the diet in primary prevention trials.


Double vision or looking and seeing.

Double vision or looking and seeing.


Anomalous venous drainage of the left upper lobe. A radiographic diagnosis.


MSF: a computer-assisted radiologic reporting system. I. Conceptual framework.


The rate of cerebrospinal fluid formation proximal and distal to aqueductal obstruction in the dog.


Recurrence rates following radiation therapy of nodular and diffuse malignant lymphomas.


Charles William Bruner, M.D. 1913-1972.

Charles William Bruner, M.D. 1913-1972.


Relation of puffing to bristle and footpad differentiation in Calliphora and Sarcophaga.


The control of puffing in Drosophila hydei.


Jack Schultz. May 1, 1904--April 29, 1971.


Transcription in giant chromosomal puffs.


The present position of cardiac surgery.


Opportunistic infections.

Opportunistic infections.


Suppressors of nuclear respiratory deficient mutant pet 24 of yeast.


Production and decomposition of indoleacetic acid (IAA) by microorganisms isolated from the root zone of two crop plants.


Dexamethasone as treatment in cerebrovascular disease. 2. A controlled study in acute cerebral infarction.


Drawings by frustrated and nonfrustrated four-year-olds.


Radiologic reporting. I. Problems of structuring and coding information from diagnostic radiology. II. Medela reporting system.


Dexamethasone as treatment in cerebrovascular disease. 1. A controlled study in intracerebral hemorrhage.


A dissection of anatomy.

A dissection of anatomy.


The contributions of Sir Archibald McIndoe to surgery of the hand.


Masturbational madness: an historical annotation.


Haloperidol and chlorpromazine: a double-blind cross-over trial and clinical study in children and adolescents.


A comparative trial of haloperidol and thioridazine: management of chronic schizophrenia.


Nitrogenase of Klebsiella pneumoniae: evidence for an adenosine triphosphate-induced association of the iron-sulphur protein. The effect of various nucleotides on the Fe-containing component of nitrogenase of Klebsiella pneumoniae was investigated by ultracentrifugation and thiol-group reactivity towards 5,5'-dithiobis-(2-nitrobenzoate). In the absence of Na(2)S(2)O(4), ATP and ADP produced changes in sedimentation behaviour and thiol-group reactivity consistent with association of the protein.


Mathematical models of capillary flow: a critical review.


John Thomas Arlidge (1822-99) and the Potteries.


A note on the sensitivity of a method used to detect lead in the eighteenth century.


Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis. Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.


Kidney donor cards.

Kidney donor cards.


Ampicillin for sore throat.

Ampicillin for sore throat.


Ascites and oedema in liver disease.

Ascites and oedema in liver disease.


H. L. H. Greer.

H. L. H. Greer.


G. G. Dickie.

G. G. Dickie.


C. M. Scott.

C. M. Scott.


Kidney donation and the law.

Kidney donation and the law.


Perphenazine-amitriptyline in neurotic underachieving students: a controlled study.


Microdetermination of adrenocortical steroids by double isotope method (II). Fractional determination of corticosteroids: free and protein-bound cortisol, corticosterone in plasma.


Demonstration of an inactive enzyme antigen in sucrase-isomaltase deficiency.


Serum anti-reticulin antibody as further evidence of the increased immune response to dietary antigens in coeliac children.


Effects of high pressure on the stability and activity of allosteric phosphoenolpyruvate carboxylase from Escherichia coli.


Structural change of DNA during lambda-phage lysogenization and induction.


Heterogeneity of the lytic activity for yeast cell wall observed among the components of an Arthrobacter glucanase.


Change in DNA-associated proteins with concomitant change in structure of DNA during phage induction.


Specific chemical modifications of acid proteases in the presence and absence of pepstatin.


Reconstitution of Escherichia coli 30 S ribosomal subunits from purified molecular components.


The phosphate content of Escherichia coli alkaline phosphatase and its effect on stopped flow kinetic studies.


Two forms of a structural lipoprotein in the envelope of Escherichia coli. Further characterization of the free form.


Physical studies comparing a genetically fused enzyme of the histidine operon with its component enzymes.


Increased motivation in rats with ventromedial hypothalamic lesions.


Identification of aspartic acid 52 as the point of attachment of an affinity label in hen egg white lysozyme.


Depression of agonistic behavior after diagonal band of Broca lesions in rats.


Contrasting effects of three forebrain ablations on discrimination learning and reversal in chicks.


An I pilus-determining R factor with anomalous compatibility properties, mobilizing a gentamicin-resistance plasmid.


Taxonomically significant colour changes in Brevibacterium linens probably associated with a carotenoid-like pigment.


Genetical studies on the lipopolysaccharide structure of Escherichia coli K12.


Plasmids determining I pili constitute a compatibility complex.


Robert E. Buchanan, 1883-1973.

Robert E. Buchanan, 1883-1973.


Arginine gene clusters in the Proteus-Providence group.


An esterase zymogram of Escherichia coli.


The nature of the electron-transparent zone that surrounds Mycobacterium lepraemurium inside host cells.


Transductional analysis of non-motile mutants in Proteus mirabilis.


Repair of DNA damage produced by gamma-radiation in Escherichia coli K-12 and a radiation-sensitive exrA derivative during inhibition of protein synthesis and normal DNA replication by chloramphenicol.


FTC-insulin conjugates. I. Preparation of fluorescein thiocarbamyl-insulin conjugates.


Microfluorometry on antigen-antibody interaction in immunofluorescence using antigens covalently bound to agarose beads.


DNA heteroduplex analysis of the relation between bacteriophages phiX174 and S.13.


Mechanism of DNA chain growth. XI. Structure of RNA-linked DNA fragments of Escherichia coli.


Renaturation of bacteriophage phiX174 DNA-RNA hybrid: RNA length effect and nucleation rate constant.


Intracistronic polarity during dissociation of translation from transcription in Escherichia coli.


The trpE gene of Escherichia coli K contains a recognition sequence for the K-restriction system.


Thermolability of the stringent factor in rel mutants of Escherichia coli.


The influence of anencephaly upon intrauterine growth of fetus and placenta and upon gestation length.


Partial chemical characterization of the cell wall of Nocardia asteroides strain 131.


Medical care in the USA--1932-1972. Problems, proposals and programs from the Committee on the Costs of Medical Care to the Committee for National Health Insurance.


Medical care in the USA--1932-1972. Problems, proposals and programs from the Committee on the Costs of Medical Care to the Committee for National Health Insurance. Comments.


Role of protein synthesis in the replication of yeast DNA.


Polypeptide bound to the host RNA polymerase is specified by T4 control gene 33.


Dentures for wind instrument players.

Dentures for wind instrument players.


Modification of the Andresen-Häupl activator. II.


[The insertion denture and its distal abutments].


Pros and cons of firing technique.

Pros and cons of firing technique.


Modifications of the Andresen-Häupl activator. 3.


Peroxidase mediated antimicrobial activities of alveolar macrophage granules. The 20,000g pellet obtained by centrifugation of a homogenate of rabbit alveolar macrophages has antibacterial activity in the presence of a hydrogen peroxide-generating system and iodide. Peroxidase activity has been demonstrated in this fraction. Addition of 3-amino-1,2,4-triazole diminished the antibacterial activity of the pellet-hydrogen peroxide-iodide system.


Failure of limiting antigen doses to selectively stimulate high-avidity memory cells. Mouse spleen cells secondarily stimulated with a small dose of antigen, which elicited few antibody-forming cells, produced antibodies of avidity no greater than that of antibodies synthesized by cells stimulated with an optimal antigen dose. This result is in conflict with the hypothesis that maturation of the immune response is based on competition for limiting amounts of antigen among cells with receptors of varying avidity.


Male-specific antigen: modification of potency by the H-2 locus in mice. Skin grafts from C57BL/10 (B10) male mice survive significantly longer than do B10.BR male skin grafts on (B10 x X B10.BR)F(1) females. This indicates that the H-2 locus influences the potency of the male-specific antigen in mice.


Antibiotic resistance of fecal Escherichia coli. A comparison of samples from children of low and high socioeconomic groups.


Student development and counseling.

Student development and counseling.


The sense of smell.

The sense of smell.


Developmental psychology.

Developmental psychology.


Social and community interventions.

Social and community interventions.


Griseofulvin in the prevention of experimental human dermatophytosis.


Topical steroid-antibiotic combinations: assay of use in experimentally induced human infections.


Vitamin E treatment of dermolytic bullous dermatosis: a controlled study.


Antibodies against the cytoplasm of human epidermal cells.


Mucocutaneous candidiasis in a mother and son.


Circulating antibodies in cicatricial pemphigoid.


Lithium carbonate and imipramine in prevention of affective episodes. A comparison in recurrent affective illness.


The monoamine oxidase inhibitor, phenelzine, in the treatment of depressive -anxiety states. A controlled clinical trial.


A self-contained, portable apparatus for preservation of donor kidneys.


The application of automatic methods to diagnostic bacteriology.


An unusual presentation of gas gangrene.


The use of the arterial sling tourniquet in surgical practice.


ECLIPS: an Extended Clinical Laboratory Information Processing System.


The social acceptance of the ex-mental hospital patient.


Use of a parallelometer in stomatological practice.


Instrument for making and tightening loops of ligature knots in difficultly accessible areas of the operating field.


Mathematical software for automatic acquisition and storage of medical information.


Fetal rat pancreas: differentiation of the islet cell component in vivo and in vitro.


A simple method for the determination of serum free insulin levels in insulin-treated patients.


Physical activity and ageing--a survey of Soviet literature. I. Some of the underlying concepts.


Age-dependent changes in the structure and function of mammalian chromatin. I. Variations in chromatin template activity.


Physical activity and ageing--a survey of Soviet literature. II. The effect of exercise on the various systems of the organism.


The first renal transplant at Guy's Hospital.


Physical activity and ageing--a survey of Soviet literature. 3. The character of physical activity; training and longitudinal results.


Sir Hedley Atkins, K.B.E. The first professor of surgery at Guy's Hospital.


The effects of the antigen gap on kidney transplantation from cadavers.


One hundred renal transplants. A clinical survey.


Immunological aspects of heart transplantation.


The examined life: in tribute to Bertram D. Lewin (1896-1971).


Raymond de Saussure (1894-1971).

Raymond de Saussure (1894-1971).


Gustav Bychowski (1895-1972).

Gustav Bychowski (1895-1972).


Problems of the therapeutic alliance: Freud and the Wolf Man.


Edward Glover: a biographical sketch.

Edward Glover: a biographical sketch.


The scientific works of Edward Glover.

The scientific works of Edward Glover.


Friederick Wilhelm Ludwig (1815-1895).

Friederick Wilhelm Ludwig (1815-1895).


Spinal problems of childhood paraplegia.


Neurological disease and scoliosis.

Neurological disease and scoliosis.


The surgical treatment of idiopathic scoliosis.


Transport of sugars and amino acids in bacteria. VI. Changes induced by valine in the branched chain amino acid transport systems of Escherichia coli.


Covalent attachment of a fluorescent group to 4-thiouridine in transfer RNA.


Dissociation of the lac repressor into subunits.


The formation of the feeding organelle in Paramecium aurelia.


Processing small delicate biological specimens for scanning electron microscopy.


Reaction of ribosomal sulfhydryl groups with 5,5'-dithiobis(2-nitrobenzoic acid).


Pairing of inosine with adenosine in codon position two in the translation of polyinosinic acid.


Role of DNA topology in transcription of coliphage lambda in vivo. II. DNA topology protects the template from exonuclease attack.


An immunochemical characterization of glucosylation in bacteriophage T4.


Lac messenger RNA in lac Z gene mutants of Escherichia coli caused by insertion of bacteriophage Mu.


Special transfer coping for better-contoured crowns.


The tissue bar and Ceka anchor as aids in cleft palate rehabilitation.


Radiographic testing of metal castings for use in dental implants.


Fabrication of a prosthesis for guiding and fixing radioactive sources in treatment of cancer of the floor of the mouth.


Fluid denture resin processing in a rigid mold.


Thrombophlebitis following diazepam.

Thrombophlebitis following diazepam.


Antibody responses in germ-free chickens to bacteria isolated from various sources.


Inhibition of cell to cell transfer of Shigella by treatment with some antibiotics.


Gas chromatography for rapid differentiation of bacterial infections in man.


PN programs accredited by the National League for Nursing-1972, Department of Practical Nursing Programs.


Partial colpocleisis by a modification of LeFort's operation.


A new treatment for yeast vaginitis.

A new treatment for yeast vaginitis.


Endometrial cytology by a new technic.

Endometrial cytology by a new technic.


Strain specific immunity to Plasmodium berghei: a new genetic marker.


The organization of the ookinete and observations on nuclear division in oocysts of Plasmodium berghei.


Some simple home remedies widely used for sick children in 1846.


Continuous distending pressure in hyaline membrane disease: of devices, disadvantages, and a daring study.


Herbert Birch.

Herbert Birch.


A device for administration of continuous positive airway pressure by the nasal route.


Continuous positive airway pressure delivered by face mask in infants with the idiopathic respiratory distress syndrome: a controlled study.


The relationship of intelligence and cerebral mantle in treated infantile hydrocephalus. (IQ potential in hydrocephalic children).


The evaluation of racemic epinephrine in the treatment of infectious croup.


Organ transplant, body image, psychosis.


The intrapsychic integration of a new organ. A clinical study of kidney transplantation.


Feminine psychosexual development in Freudian theory. A historical reconstruction.


Kant's way: the psychoanalytic contribution of David Rapaport.


Victor H. Rosen. 1911-1973.

Victor H. Rosen. 1911-1973.


Tissue specificity of genetic transcription.


Nucleic acid hybridization to isolated chromatin.


A long-term review of dermal grafts and bronchial reconstruction.


Genetics and the C3 molecule.

Genetics and the C3 molecule.


Comparative ultrastructural study of normal and grafted skin in the frog, Rana pipiens, with special reference to neuroepithelial connections.


Rabbit-to-dog liver xenograft as a model for study of the process of hyperacute rejection.


Studies on the mechanism of hyperacute rejection of rabbit-to-dog liver transplants.


Intravascular coagulation in hyperacutely rejected liver xenografts.


Prolongation of rabbit-to-dog liver xenograft survival in recipients pretreated with rabbit blood.


Experimental preservation of liver from hypotensive donor and with prolonged warm ischemia.


Technique of orthotopic liver allotransplantation in dogs.


Biochemical and ultrastructural changes in dog and pig livers procured for transplantation.


Biochemical signs of early rejection of liver allografts in dogs.


Comparison of the effect of horse anti-dog lymphocyte globulin (HADLG) on renal and liver transplants in dogs.


Vagotomy and antropylorectomy in the surgical treatment of peptic ulcer.


Central ventriculography with Dimer-X.

Central ventriculography with Dimer-X.


Determination of some L-amino acids in biological samples by aminoacylation of tRNA.


Fibrinolysis in retinal vein occlusions. A preliminary report.


Ribonuclease: a spectrophotometric assay using acridine orange--RNA complex.


An alkaline phosphatase-linked assay for ribonucleases.


A press for cell disruption by ice shear.


Stoicheiometry of lactose-H+ symport across the plasma membrane of Escherichia coli. The rate of [(14)C]lactose inflow into anaerobic, non-metabolizing, Escherichia coli has been correlated with the rate of the simultaneous effective inflow of H(+). It is shown that the initial rates of the two transport processes are essentially the same, and it is concluded that the two processes are strictly coupled with a 1:1 stoicheiometry.


Polymorphism in fowl serum albumin. IV. Isolation and characterization of liver polyribosomes.


Nature of the base sequence conserved in the mitochondrial DNA of a low-density petite.


Studies on the interaction of tyrosyl-tRNA synthetase from Escherichia coli K12 with tyrosine and with tyrosyl-AMP.


Purine-pyrimidine requirement for ribonucleic acid synthesis in an Escherichia coli mutant defective in potassium accumulation.


Sparsomycin requirement for inhibiting peptide-bond formation.


Fluorescent antibody studies in malignant melanoma.


BCG immunotherapy of rat sarcomata.

BCG immunotherapy of rat sarcomata.


Antibodies and soluble tumour-specific antigens in blood and lymph of rats with chemically induced sarcomata. In confirmation of other studies it has been shown that antibody directed against the tumour specific transplantation-type antigens (TSTAs) cannot be detected in rats with a tumour growing intramuscularly but appears within a few days after excision of the tumour. Circulating antibody is found in the serum of rats with lymph node metastasis following excision of the primary. Absorption by the intramuscular tumour of circulating antibody does not account for the absence of antibody since the antibody levels in thoracic duct lymph in rats with tumours in the leg are also very low and rise rapidly after tumour excision. Antibody is released by the draining nodes directly into the lymph and must pass through the thoracic duct before entering the blood. Under these conditions low levels of antibody activity in lymph cannot be ascribed to absorption by the tumour.It is postulated that TSTA is released from the tumour into the lymph. Following injection of tumour cells into immunized rats the level of antibody falls and this is attributed to release of TSTA from the injected cells. The possible role of antigen release from tumours in determining the host reaction to the tumour is discussed.


The role of macrophages in classic Marek's disease.


Factors associated with anencephalus and spina bifida in Belfast.


Fetal and infant mortality associated with congenital malformations.


The effect of iron on the growth of Escherichia coli in albumen taken from the hen's egg.


The bacteriological condition of eviscerated chickens processed under controlled conditions in a spin-chilling system and sampled by two different methods.


Atmospheric reaeration capacity of streams. I. Critical review of methods available to measure and to calculate the atmospheric reaeration rate constant.


Pathological study of the cat spinal cord after chronic local implantation of aluminum hydroxide.


IgM levels of newborn in Hawaii.

IgM levels of newborn in Hawaii.


Immunoglobulins and lymphocyte populations.


Hypophysial feed-back in the hypothalamic regulation of luteinizing hormone secretion.


The nebulous scope of current psychiatry.


The effects of halothane on ovulation in the rat.


Differentiation of dissociated neurons from chick embryo cerebral hemispheres cultivated in Rose chambers with and without cellophane membrane.


Insulin release from isolated islets of Langerhans of the rat in organ culture.


Hemoglobin concentration changes determined in populations of living host erythrocytes during Plasmodium berghei infection in mice.


Primary cerebral blastomatous reticulosis. Clinical, pathohistological and ultrastructural study.


The effect of aldactone-A on intracellular potassium in patients with myasthenia gravis.


Diffuse Rosenthal fiber formation in the adult: a report of four cases.


The use of rating scales for computer analysis of the affective symptoms in old age.


The maintenance of arterial constriction at different transmural pressures. 1. Distensibility characteristics of the isolated, perfused rabbit ear artery were measured in the presence and absence of different concentrations of adrenaline.2. The major effect of varying the adrenaline concentration was to vary the radius at which active tension first developed. This radius was inversely related to the adrenaline concentration.3. Increases in radius of the constricted artery produced by pressures rising from 40 to 150 mm Hg were small relative to the increase in wall stress. Distension was opposed largely by increases in active tension. With some arteries (60%) an increase in pressure between 30 and 80 mm Hg was associated with a decrease in radius when low concentrations of adrenaline were present.4. The ability of the constricted ear artery to resist distension at transmural pressures of 100 mm Hg was uninfluenced by the adrenaline concentration provided constriction exceeded 28% of maximal. The static, incremental, circumferential modulus of the artery wall varied little from a value of 6.5 x 10(6) dyn/cm(2).5. The maximum active tension required to maintain constriction was inversely related to the degree of constriction and hence to the adrenaline concentration. The modulus for fully or near-fully activated muscle was 18.5 x 10(6) dyn/cm(2) of media.6. Muscle function deteriorated following exposure of constricted arteries to pressures sufficient to overwhelm the constriction.7. These observations may be explained by a negative feedback system where the contractile elements are arranged in parallel with a length sensor element whose setting is determined by the concentration of adrenaline. The length sensor may be the cell membrane. It is concluded that a radius increase may be a primary stimulus for blood flow auto-regulation.


Experimental glomerulonephritis in the guinea pig. I. Glomerular lesions associated with antiglomerular basement membrane antibody deposits.


The Kanematsu Institute--forty years on.


Myofibroblasts in an avascular fibrous tissue.


Determination of the pulsatile blood flow by a radiographic method.


Controlled clinical trial of a new bile acid-sequestering resin, colestipol, in the treatment of hypercholesterolaemia.


Myeloma treated with cyclophosphamide and terminating in reticulum cell sarcoma.


James Ian De Boer Leembruggen.

James Ian De Boer Leembruggen.


The development of pathological anatomy in Hungary.


Release of bone marrow colony stimulating activity during immunological reactions in vitro.


Endocrine function of the allotransplanted pancreas in dogs.


Molecular interactions and structure as analysed by fluorescence relaxation spectroscopy.


The lesions produced by ultraviolet light in DNA containing 5-bromouracil.


Ultrastructure of the intestinal lymphatics in regard to absorption.


A double-blind study of the effect of carbenoxolone sodium in the treatment of gastric ulcer.


Gastric secretory relationship between H+ and pepsin in fistula chickens.


Gastric H+ and pepsin secretion in gastritis.


Tubular packing of spheres in biological fine structure. The symmetrical arrangements of monomers into such cylindrical structures as microfilaments of actin, flagella of bacteria, microtubules of many organisms, and the protein coats of viruses can be specified by citing the index numbers of two or three sets of contact parastichies, or helical ranks of monomers, as has been done in classical studies of phyllotaxis. This specification has the form k(m, n) or k(m, n, m+n), where m, n, and (m+n) are parastichy numbers specifying screw displacements, and k is the jugacy, or frequency of rotational symmetry. For simple structures, k = 1. This notation has the advantage of terseness and of indicating the basic isometries of these helically symmetrical structures. Theoretical models of the packing of spheres whose centers lie on the surface of a cylinder have been investigated geometrically. Their symmetry properties are discussed. Parameters of these models, such as the angular divergence, alpha, the longitudinal displacement between successive spheres, h, the radius of the cylinder, and the angles of inclination of the parastichies, have been computed for representative patterns. The ultrastructural symmetry of several biological structures of this sort has been inferred by comparison with these models. Actin, for example, has the symmetry (1, 2), Salmonella flagella, 2(2, 3, 5), the tobacco mosaic virus, (1, 16, 17) and the microtubules of many higher organisms, (6, 7, 13).


Mitochondrion of yeast: ultrastructural evidence for one giant, branched organelle per cell. Three-dimensional models constructed from 80 to 150 consecutive serial sections of entire yeast cells showed that all the separate mitochondrial profiles were cross sections through a single, branching, tubular structure about 50 to 60 micrometers in length and 200 to 600 nanometers in diameter. The data are contrary to conventional notions of mitochondrial size, form, and number per cell and should lead to a reassessment of mitochondrial genetics and biogenesis.


Egas Moniz 1874-1955.

Egas Moniz 1874-1955.


A tribute to Sir Francis Walshe.

A tribute to Sir Francis Walshe.


Percival Bailey 1892-1973.

Percival Bailey 1892-1973.


Diamond Jubilee year.

Diamond Jubilee year.


Pseudoxanthoma elasticum. An historical survey.


An indicator-dilution method for studying intestinal hemodynamics in the cat.


A two-phased change in dynamic lung compliance during hemorrhagic hypotension.


Arion's suture in blepharoptosis correction.


Leukocyte migration inhibition in chronic ophthalmic disorders. 5. Diabetic retinopathy and the effect of photocoagulation.


Derrick Vail and the American Journal of Ophthalmology.


Derrick Tilton Vail, M.D. 1898-1973.

Derrick Tilton Vail, M.D. 1898-1973.


Rating the characteristics of malocclusion: a systematic approach for planning treatment.


Our medical literature--then and now.

Our medical literature--then and now.


Selective bibliography on medical education.


The utilization of fructose by Escherichia coli. Properties of a mutant defective in fructose 1-phosphate kinase activity. 1. The isolation and properties of a mutant of Escherichia coli devoid of fructose 1-phosphate kinase activity are described. 2. This mutant grew in media containing any one of a variety of substances, including hexoses, hexose 6-phosphates, sugar acids and glucogenic substrates, at rates not significantly different from those at which the parent organism grew on these substrates. However, only the parent grew on fructose or fructose 1-phosphate. 3. Fructose and fructose 1-phosphate inhibit the growth of the mutant, but not of its parent, on other carbon sources. 4. Even though not previously exposed to fructose, the mutant took up [(14)C]fructose rapidly but to only a small extent: [(14)C]fructose 1-phosphate was identified as the predominant labelled product. In contrast, the equally rapid but more extensive uptake of [(14)C]fructose by the parent organism required prior growth in the presence of fructose.


Pulmonary edema of environmental origin.


Salmonella pericarditis: an unusual complication of myocardial infarction.


A simple method for aortic cannulation.

A simple method for aortic cannulation.


Intestinal mucosa and vitamin B12 absorption.


The malaria incidence and species prevalence among the population of the Lambwe Valley, South Nyanza, Kenya.


Annotated selected bibliography on the patient record system.


Due-care.

Due-care.


Effects of rifampicin, streptolydigin and actinomycin D on the replication of Col E1 plasmid DNA in Escherichia coli.


Selective modification of cytidine and uridine residues in Escherichia coli formylmethionine transfer ribonucleic acid.


Kidney transplantation in children: psychosocial follow-up study on child and family.


Clinical correlates of antinuclear antibodies in juvenile rheumatoid arthritis.


Renal autotransplantation in the treatment of bilateral renal artery stenosis: relief of hypertension in an 8-year-old boy.


Bullous pemphigoid and membranous glomerulonephropathy in a child.


Re-evaluation of a galactosemic family by enzymatic and electrophoretic methods.


Episodic seizures and coma in a 14-year-old boy.


Resistance of shigellae to ampicillin and other antibiotics: South Bronx New York (1971 and 1972).


Residencies and fellowships in pediatric subspecialties and general academic pediatric training.


Potential biologically active agents. V. Synthesis and pharmacological screening of substituted 3-aminomethylbenzoxazolin-2-thiones.


Tremor induction by intracaudate injections of bretylium, tetrabenazine, or mescaline: functional deficits in caudate dopamine.


Modified technique for orthotopic cardiac transplantation in dogs.


Canine bilateral lung autotransplantation--postoperative ventilatory and hemodynamic responses to carbon dioxide.


Medical practice and practitioners in eighteenth century Maryland.


Angular inflammation.

Angular inflammation.


Isolation and identification of pulmonary lamellar bodies from guinea pigs.


The isolation of the plasma membrane from a gram-negative organism.


Some historical aspects of the neuropathology of canine distemper.


Electron microscopy of endothelial cells collected on cellulose acetate paper.


A bacteriologic study of Madison area beaches.


Fructose and purine metabolism.

Fructose and purine metabolism.


Intestinal absorption of sucrose.

Intestinal absorption of sucrose.


Effect of fructose and other sugars on islet function in vitro.


Metabolic effects of dietary fructose in insulin dependent diabetes of adults.


Effect on serum lipids of dietary sucrose and fructose.


Intestinal metabolism of fructose.

Intestinal metabolism of fructose.


The significance of sucrose in production of hypertriglyceridemia.


Control of hepatic fructose-metabolizing enzymes: fructokinase, aldolase and triokinase.


Hereditary alterations of fructose metabolizing enzymes. Studies on essential fructosuria and on hereditary fructose intolerance.


Hereditary fructose intolerance.

Hereditary fructose intolerance.


Fructose--sweet without risk for health? Opening of the symposium.


Analysis of reported physiologic effects of microwave radiation.


Mechanical, biochemical, and architectural features of surgical repair.


Transmission of pictorial information through the skin.


The effect of Escherichia coli enterotoxins on the small intestine with or without direct mucosal contact.


Cytology automation.

Cytology automation.


In vitro iron attachment to the intestinal brush border. Effect of iron stores and other environmental factors.


Diagnosis of pancreatic exocrine insufficiency by fecal chymotrypsin activity.


Biochemical measurements in the assessment of the protein nutrition status.


Aharon Katchalsky 1914-1972.

Aharon Katchalsky 1914-1972.


Computer information project for monographs at the Medical Research Library of Brooklyn. The article describes a resource library's computer-based project that provides cataloging and other bibliographic services and promotes greater use of the book collection. A few studies are cited to show the significance of monographic literature in medical libraries. The educational role of the Medical Research Library of Brooklyn is discussed, both with regard to the parent institution and to smaller medical libraries in the same geographic area. Types of aid given to smaller libraries are enumerated. Information is given on methods for providing machine-produced catalog cards, current awareness notes, and bibliographic lists. Actualities and potentialities of the computer project are discussed.


THIS is where it's at.

THIS is where it's at. The Medical Center Library contracted to provide bibliographic information services for the Tobacco and Health Research Institute of the University of Kentucky. This new department is now an integral part of the Medical Center Library providing reference and literature services in the tobacco and health area. Operating as a quasi-independent unit of the Medical Center Library, THIS (Tobacco and Health Information Services) functions separately in all areas of library operations, or more specifically, as a special library within a library. Its collection differs from that of most libraries in that it consists almost solely of periodical reprints instead of books and journals. The diversity of disciplines which tobacco and health literature encompasses has created the need for the development of a current awareness service for researchers. It is the belief of the author that there is a definite trend toward library collections such as THIS within larger medical libraries, as more institutes with special areas of interest are being formed.


The history of medical libraries from 2000 B.C. to 1900 A.D. Tablets said to date back to 2000 b.c. represent the earliest medical writings so far discovered. The history of the medical library (defined as a place where a collection of medical writings is kept) is traced through ancient and medieval civilizations, and the dependence of advancement or decline on the attitude toward learning and knowledge is demonstrated.The change in structure of medical libraries that took place around the 1500s with the development of scientific societies is discussed. Medical libraries of Colonial America are described and the history is brought forward to the era of public library collections of medical material in the early 1900s.


Sarah Cole Brown. President, Medical Library Association 1973 74.


An endonuclease for depurinated DNA in rat liver.


Riboflavin and cancer: a review.

Riboflavin and cancer: a review.


Immunological reaction in keratoacanthoma, a spontaneously resolving skin tumor.


Bactericidal and bacteriolytic activity of leukemic sera.


Epidermal antigens in experimental keratoacanthoma and squamous cell carcinoma.


Human thymus lymphoid tissue (HTL) antigen, complement receptor and rosette formation with sheep erythrocytes of the lymphocytes from primary immunodeficiency diseases.


Human lymphocyte subpopulations. Human thymus-lymphoid tissue (HTL) antigen-positive lymphocytes forming rosettes with sheep erythrocytes and HTL antigen-negative lymphocytes interacting with antigen-antibody-complement complexes.


Enhanced in vitro phagocytic power of macrophages from PPD-stimulated skin sites in human subjects hypersensitive to PPD.


Locating brain tumours through depth EEG probes.


Parabiosis between obese (OS) and normal strain chicken embryos. Examination of skin grafts, lymphocyte chimerism and autoimmune thyroiditis.


Clinical application of a new stereotaxic instrumentation.


The ventricular fluid pressure and the concentration of homovanillic acid in different parts of the cerebrospinal fluid system in patients with Parkinson's disease.


Intrathalamic and intraventricular application of hydrocortisone during stereotatic operations.


Long-term effects on verbally expressed cognition following left and right ventrolateral thalamotomy.


Structural-functional organization of the human brain and the pathophysiology of the Parkinsonian type hyperkineses.


The anatomy of the corpus callosum determined electrically during stereotactic stimulation in man.


Stereotaxic amygdalotomy in temporal lobe epilepsy.


Anatomical correlation of detailed sensory mapping of the human thalamus.


Sagittal thalamotomy for relief of motor disorders in cases of double athetosis and cerebral palsy.


Somatotopic array of the ventro-oral nucleus of the thalamus based on electrical stimulation during stereotactic procedures.


Related subthalamic structures.

Related subthalamic structures.


Histological and clinical correlations in 29 Parkinson patients with stereotaxic surgery.


Electromyographic study of motor responses following electrical stimulation of the corticospinal tract in man during stereotaxy.


Stereotaxic lower cervical cordotomy for the treatment of intractable pain.


Plasma renin activity (PRA) in Parkinson's disease before and after stereotaxic operation.


The H-reflex in patients with Parkinson syndrome before and after stereotaxic procedures and drug administration.


Dentatotomies or thalamotomies in the treatment of hyperkinesia.


Hypokinetic syndromes and their therapy.


Long-term results of stereotactic treatment of spasmodic torticollis.


Stereotaxic treatment of extrapyramidal myoclonus.


Physiopathological observations on the mechanism of stimulus sensitive myoclonus. A stereotactic study.


Clinical picture of cerebral palsy in neurological understanding.


Correlation between anatomically calculated target point and physiologically determined point in stereotaxic surgery.


Computer calculation of the position of the side-protruding electrode tip during penetration in human brain.


The practical side of professional unity.


Guidelines for reporting clinical trials.


Pre- and postoperative management of elderly surgical patients. The Edward Henderson Award lecture.


Sex in retrospect.

Sex in retrospect.


Mercury as an environmental hazard.

Mercury as an environmental hazard.


Multiple and specific initiation of T4 DNA replication. Partially replicated T4 DNA molecules (PRM) whose parental or progeny DNA was labeled with bromodeoxyuridine BUdR was analyzed by gradual shearing followed by CsCl banding of the sheared product. Analysis of PRM containing 18-mum replicated DNA showed that each replicated region was 3- to 6-mum long, indicating three to 6 replicative sites per molecule. Analysis of PRM containing 9-mum replicated DNA similarly indicated two to three replicated regions per molecule. DNA from the replicated regions of PRM containing 10-mum replicated DNA ("donor") was hybridized to DNA from mature phage ("recipient"), and the resulting hybrid was subjected to digestion with exonuclease I. The extent of protection of the recipient and more efficient self-annealing of progeny fragments from PRM indicated that the replicated regions represented 8 to 10 nonrandom locations of the genome. Possible significance of multiple sites for initiation of DNA replication is discussed.


Mutagenic effect of temperature-sensitive mutants of gene 42 (dCMP hydroxymethylase) of bacteriophage T4. Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.


Injection of ultraviolet-damage-specific enzyme by T4 bacteriophage. When UV-irradiated T4 bacteriophage (v(+)) infects in the presence of chloramphenicol, the phage DNA rapidly acquires single-stranded breaks proportional to the dose of UV. In contrast, when UV-irradiated T4 v(1) (radiation sensitive mutant) infects under identical conditions, the phage DNA remains integral. A series of coinfections with v(+) and v(1) phage (UV-v(1) + majority non-UV-v(+) and UV-v(+) and majority non-UV-v(1)) show that the enzyme responsible for breakage is injected by the phage. It is also demonstrated that the v(1) phage injects an inactive enzyme that delays breakage by the v(+) enzyme and interferes with subsequent repair. The cross of v(+) and v(1) phage produces mixed progeny that contain both active and inactive enzyme in a single capsid. The possible function of this breaking enzyme, necessitating injection of multiple copies, is considered.


Assembly and function of the lambdoid bacteriophage tail: observations from phi 80-lambda host-range phenotypic mixing. The host-range proteins of lambda and phi80, while differing sharply in host-receptor specificity and in sensitivity to phage-killing antiserum, can be assembled into functional phage tail structures of mixed composition.


Regulation of early mRNA synthesis in bacteriophage T4-infected bacteria: dependence on bacteriophage-specific protein synthesis. The mechanism of the transcriptional turn-off was studied for those species of mRNA in T4 infection which specify early phage proteins. Total synthesis of these early RNA species was determined by short-time labeling with uracil-5-(3)H after the infection of Escherichia coli B with DNA-negative, conditional lethal mutants, which produce no late mRNA under nonpermissive conditions. With both amber and temperature-sensitive mutants a decrease in incorporation into early RNA by more than 90% was observed within 15 min after infection. Analysis by thin-layer chromatography showed uracil-5-(3)H to enter nucleotide pools throughout the infection cycle. The observed decrease in early RNA synthesis was dependent on protein synthesis, since it could be prevented by chloramphenicol. By varying the time of chloramphenicol addition, the effect of this regulatory protein(s) was found to appear at 3 to 4 min and reached its full extent at 10 to 15 min after infection. The turn-off of transcription of a defined early gene was studied by 5-fluorouracil (FU) rescue of an early, DNA-negative, amber mutant (gene 1, deoxynucleotide kinase) at different times after infection. DNA synthesis could be rescued by FU addition early after infection, but not after 12 min. 5-fluorouracil was efficiently taken up into the nucleotide pools also at late times, as shown by thin-layer chromatography. After incubation in the presence of chloramphenicol from 3 min after infection, DNA synthesis could be rescued as late as 45 min after infection. Thus, when protein synthesis was blocked during the early period of infection, the shut-off of transcription of the studied early gene was prevented.


Inactivation of T4D bacteriophage by antiserum against bacteriophage dihydrofolate reductase. Antiserum was prepared against highly purified T4D bacteriophage-induced dihydrofolate reductase (DFR). This serum not only inactivated the enzyme but also inactivated all strains of T4D examined. T6 was inactivated to a lesser extent, and T2L, T2H, and T5 were unaffected by the antiserum. The phage-killing power of the serum could be blocked by prior incubation with partially purified T4D dfr obtained from host cells unable to make phage structural proteins. These observations confirm earlier results that the phage dfr is a structural component of the phage particle, and they offer new evidence on the manner in which this enzyme in incorporated into the tail structure.


Human toxoplasmosis in Tasmania.

Human toxoplasmosis in Tasmania.


Kerrod Bromley Voss.

Kerrod Bromley Voss.


Gilbert George Bradley.

Gilbert George Bradley.


Emil Milder.

Emil Milder.


Gerald Carew Moss.

Gerald Carew Moss.


Vertebrobasilar ischaemia and the extracranial arteries.


The care of destitute children in Australia.


John Rothwell Radcliff.

John Rothwell Radcliff.


The last step of the excision repair of DNA in the amino acid prestarved and ultraviolet irradiated cells of Escherichia coli B-r Hert.


Treatment of bone sarcomas of the extremities by radiation therapy under tourniquet hypoxia.


A neuropsychopharmacological study of phenmetrazine in several animal species.


In memoriam. Hieronymus van Praag Koch.

In memoriam. Hieronymus van Praag Koch.


Photoregulated carotenoid biosynthesis in non-photosynthetic microorganisms.


Health and the population. Structure and substance.


A device for the precise transfer of serial sections for electron microscopy.


Transmission electron microscopy of tissue culture preparations on polystyrene coverslips.


Softening hair with dithiothreitol (Cleland's reagent) for histological sectioning in paraffin.


Antimicrobial activity in the skin secretions of Bombina variegata pachypus.


The immunodiagnosis of hydatid disease: post-operative evaluation of the skin test and four serological tests.


Antibodies to factor VIII. I. Variations in stability of antigen-antibody complexes in hemophilia A.


Effect of splenectomy and endotoxin-mediated modification of host resistance to infection.


Suppression of ultraviolet sensitivity in Escherichia coli uvr502 by the su58 missense suppressor. Introduction of the su58 missense suppressor into the chromosome of the uvr502 mutant, either by mutation or by transduction, results in a marked increase of ultraviolet resistance of the uvr502 mutant. In the uvr(+) genetic background, the su58 suppressor causes some decrease of ultraviolet resistance and marked increase in the spontaneous mutation frequency. The presence of the su58 suppressor did not decrease the high frequency of spontaneous mutants in the population of the uvr502 strain. However, the significant increase in spontaneous mutant frequency in the uvr(+)su58 strain makes the difference between the uvr502 su58 and the uvr(+)su58 strains 18 times lower than that between the uvr502 and the uvr(+) suppressor-free strains. Since the missense suppressors act at the level of translation, the results suggest that the product of the uvr(502) gene is a protein.


Deoxyribonucleic acid breaks in heated Salmonella typhimurium LT-2 after exposure to nutritionally complex media. Minimal medium recovery of heat-treated Salmonella typhimurium LT-2 has been expressed as the reduced viability on trypticase soy agar supplemented with 0.5% yeast extract (TSY) relative to a glucose-salts (M-9) agar. Incubation of S. typhimurium LT-2 in water at 50 C for 15 min did not change the sedimentation patterns of deoxyribonucleic acid (DNA) in alkaline sucrose gradients. The same pattern was obtained if the heated cells were further incubated for 15 min at 37 C in M-9 broth. However, a marked increase in DNA single-strand breakage accompanied by a loss of viability was observed after a similar incubation of heated bacteria in TSY broth. If heated bacteria were incubated in M-9 broth before TSY broth, there was a decrease in the single-strand breakage occurring in the TSY broth. This decrease is believed to be the result of repair of heat-induced damage. We conclude that minimal medium recovery after heat treatment is due to DNA damage caused by sequential exposure to heat and TSY medium, such damage not occurring after sequential exposure to heat and M-9 medium.


Transport of vitamin B12 in Escherichia coli: genetic studies. The chromosomal location of two genetic loci involved in the transport of cyanocobalamin (B(12)) in Escherichia coli K-12 was determined. One gene, btuA, is believed to code for the transport protein in the cytoplasmic membrane, because a mutant with an alteration in this gene has lost the ability to accumulate B(12) within the cell although normal levels of the surface receptors for B(12) are present. The other locus, btuB, apparently codes for the surface receptor on the outer membrane. These mutants have lost the ability to bind B(12) and have greatly reduced transport activity, although growth experiments have shown that they can utilize B(12) for growth, but with decreased efficiency. This surface receptor for B(12) also appears to function as the receptor for the E colicins, because btuB mutants are resistant to the E colicins, and mutants selected for resistance to colicin E1 are defective in B(12) binding and transport. The gene order was determined by transduction analysis to be cyc-argH-btuA-btuB-rif-purD. In addition, mutations in metH, the gene for the B(12)-dependent homocysteine methylating enzyme, were obtained in this study. This gene was localized between metA and malB.


Transport of vitamin B12 in Escherichia coli: common receptor sites for vitamin B12 and the E colicins on the outer membrane of the cell envelope. The first step in the transport of cyanocobalamin (CN-B(12)) by cells of Escherichia coli was shown previously to consist of binding of the B(12) to specific receptor sites located on the outer membrane of the cell envelope. In this paper, evidence is presented that these B(12) receptor sites also function as the receptors for the E colicins, and that there is competition between B(12) and the E colicins for occupancy of these sites. The cell strains used were E. coli KBT001, a methionine/B(12) auxotroph, and B(12) transport mutants derived from strain KBT001. Colicins E1 and E3 inhibited binding of B(12) to the outer membrane B(12) receptor sites, and CN-B(12) protected cells against these colicins. Half-maximal protection was given by CN-B(12) concentrations in the range of 1 to 6 nM, depending upon the colicin concentration used. Colicin E1 competitively inhibited the binding of (57)Co-labeled CN-B(12) to isolated outer membrane particles. Functional colicin E receptor sites were found in cell envelopes from cells of only those strains that possessed intact B(12) receptors. Colicin K did not inhibit the binding of B(12) to the outer membrane receptor sites, and no evidence was found for any identity between the B(12) and colicin K receptors. However, both colicin K and colicin E1 inhibited the secondary phase of B(12) transport, which is believed to consist of the energy-coupled movement of B(12) across the inner membrane.


Conservation of Salmonella typhimurium deoxyribonucleic acid in partially diploid hybrids of Escherichia coli. Partially diploid Escherichia coli K-12 hybrids recovered from mating with a Salmonella typhimurium Hfr strain were found to differ with respect to the manner in which they conserved the added Salmonella deoxyribonucleic acid (DNA). Five of the diploid hybrids examined appeared to maintain the Salmonella DNA as part of a functional F-merogenote; these hybrids were sensitive to the male-specific phage, R-17, responded as males to the female-specific phage, phiII, and transferred their inherited Salmonella genetic markers at high frequency in conjugation experiments. Six diploid hybrids were observed which were not sensitive to R-17, and from which the added Salmonella DNA was not transmissible in conjugation tests; nevertheless, these hybrids responded as males to phiII, and the Salmonella chromosomal fragments were conserved in them as parts of supercoiled, circular DNA elements. It was concluded that these circular DNA elements were defective F-merogenotes, unable to direct the synthesis of F-pili. Three diploid hybrids were found which were not sensitive to R-17, and which responded as females to phiII; no circular DNA was found in them, and it was concluded that their conservation of the Salmonella genetic fragments was accomplished in some manner which did not involve association with F or assumption of the supercoiled circular configuration. Other partially diploid hybrids were observed which appeared similar to these latter three hybrids with regard to their conservation of the Salmonella DNA, but which also contained an infecting F-factor; in these hybrids, both genetic and molecular experiments indicated that the unstably conserved Salmonella DNA was not associated physically with the F-factor.


Polyamine requirements of a conditional polyamine auxotroph of Escherichia coli. Escherichia coli MA-159 is deficient in agmatine ureohydrolase. After addition of exogenous arginine, the cellular putrescine content declines immediately and exponentially; however, the spermidine content remains normal for 3 h. The growth rate of such cultures, measured turbidometrically, slows gradually over many hours. Putrescine-depleted cultures grow especially slowly in media of low osmolarity, whereas nondepleted cultures grow at similar and rapid rates in media of either normal or low osmolarity. External osmolarity also affects the ability of various exogenous polyamines to stimulate growth of putrescine-depleted cultures. In medium of normal osmolarity, putrescine and spermidine both allow sustained rapid growth for many hours. In low osmolarity medium, putrescine allows sustained rapid growth, whereas cultures containing spermidine grow more slowly; this result cannot be explained by conversion of putrescine to spermidine, for cultures grown with exogenous putrescine contain smaller spermidine pools than do cultures grown with exogenous spermidine. Spermine greatly stimulates growth in medium of normal osmolarity; however, in medium of low osmolarity, spermine is much less effective and can block the action of putrescine. Several other polyamines have been studied in this system. These results confirm and expand previous reports that polyamines are necessary for growth of E. coli and suggest that putrescine may have a specific function during growth in media of low osmolarity.


Derepression of anthranilate synthase in purified minicells of Escherichia coli containing the Col-trp plasmid. Purified minicells of Escherichia coli K-12 containing the plasmid Col-trp(+) or Col-trpA2 could be derepressed for the synthesis of anthranilate synthase, the first enzyme encoded in the trp operon. Non-plasmid-containing, deoxyribonucleic acid-deficient minicells could not be derepressed. Derepressed enzyme synthesis was initiated by l-tryptophan starvation. The kinetics of derepression were studied with minicells containing the Col-trpA2 plasmid. The derepression curves were biphasic with a rapid initial rate of enzyme synthesis followed by a slower rate of synthesis. The presence of l-tryptophan (20 to 50 mug/ml) or chloramphenicol (200 mug/ml) abolished enzyme synthesis. The presence of rifamycin SV (280 mug/ml) partially inhibited enzyme synthesis after at least 3.5 min of exposure. The ratio of minicell-to-cell synthetic capacity was 1:2.4 when compared on the basis of derepressed enzyme activity per unit cell volume. This work demonstrates that plasmid-containing minicells are capable of considerable functional protein and messenger ribonucleic acid synthesis and that the regulation of at least the trp operon is similar in minicells to that observed in cells.


Effect of Zn2+ on bacterial conjugation: increase in ability of F- cells to form mating pairs. Incubation of F(-) cells at 37 C with 10(-3) M Zn(2+) before mating was found to increase the ability of F(-) cells to form mating pairs when mated. This increased pair-forming ability is persistent, at least for the duration of mating. The F(-) cells with increased pair-forming ability obtained by the 10(-3) M Zn(2+) treatment can form mating pairs efficiently with males from which F pili were removed or inactivated with 10(-3) M Zn(2+).


Quantitative measurement of the effectiveness of unsaturated fatty acids required for the growth of Saccharomyces cerevisiae. The growth response of a mutant of Saccharomyces cerevisiae which is unable to synthesize unsaturated fatty acids has been measured in the presence of variable concentrations of exogenous unsaturated fatty acids. Final cell yields, doubling times, and lag times were all found to vary as a function of the initial concentration of the added unsaturated acid. The cell yield was found to be a convenient quantitative measurement to use in comparing the effectiveness of various unsaturated acids. Values for the acids ranged from 1.7 to 11 cells per femtomole with values for oleate and palmitoleate at 2.7 and 4.3 cells per femtomole, respectively. In general, the effectiveness of unsaturated acids was found to increase with an increasing number of double bonds. Saturated fatty acids of a chain length of 5 to 18 carbon atoms were completely ineffective. The varied efficiencies of different unsaturated fatty acids indicate that unsaturation per se was not the basis of the nutritional requirement and indicate certain acids that would be useful in further studies of the role of unsaturated acids in cell function.


Studies on acetyl-coenzyme A synthetase of yeast: inhibition by long-chain acyl-coenzyme A esters. Long-chain acyl-coenzyme A (CoA) compounds (palmityl, stearyl, and oleyl) were found to be potent inhibitors of acetyl-CoA synthetase (ACS) of Saccharomyces cerevisiae strain LK2G12 from aerobic, but not from nonaerobic, cells. The effectiveness of the inhibitors of the aerobic enzyme was in the following order: palmityl-CoA < stearyl-CoA < oleyl-CoA. Short-chain acyl-CoA compounds (propionyl, butyryl, and valeryl) and long-chain fatty acids had no effect on ACS from either source. The inhibition by oleyl-CoA was found to be dependent on enzyme concentration, whereas the inhibition by palmityl- and stearyl-CoA was independent of ACS concentration. Inhibition by palmityl-CoA was noncompetitive with respect to both acetate and CoA, and with increasing concentration of inhibitor the pattern was sigmoidal, with a Hill value of 3.24. At maximally inhibitory concentrations of palmityl-CoA, a small amount of enzyme activity remained. This noninhibitable enzyme in aerobic cells was shown not to be of nonaerobic origin.


Transduction of rifampin resistance in group A streptococci. Rifampin-resistant strains of group A streptococci were isolated as spontaneous mutants. Transduction analyses employing phage A25 showed the rifampin marker to be transferred with high frequency. The mutations conferring resistance to rifampin and streptomycin are not co-transducible.


Thymineless death in polA+ and polA- strains of Escherichia coli. The extreme sensitivity of polA(-) cells to thymineless death is due, primarily, to the absence of an extended lag prior to the commencement of death. Once thymineless death has commenced, the rate in polA(-) cells is only slightly faster than in polA(+) cells.


Novel mutation to dominant fucose resistance in the L-arabinose operon of Escherichia coli. We isolated an unusual mutant in which the arabinose operon carried an araC lesion that led to a dominant fucose resistance while retaining recessive constitutivity. All previously characterized C(c) mutations have been recessive for both fucose resistance and constitutivity.


Genetic analysis of the system that reduces biotin-d-sulfoxide in Escherichia coli. Four genes of Escherichia coli whose products are needed to reduce biotin-d-sulfoxide to biotin have been mapped: bisA next to chlA, bisB next to chlE, bisC linked to xyl, and bisD next to chlG. A defective lambda transducing phage, lambdadbis5, which carries all the bacterial genes between the lambda attachment site and chlE, was isolated and shown to have lost the phage genes from int through Q.


In memoriam Hans van der Meulen.

In memoriam Hans van der Meulen.


The story of the enteropathic Escherichia coli.


Control of T4 endonuclease IV by the D2a region of bacteriophage T4.


Studies on bacteriophage T3. I. Kinetic studies on particle formation and role of capsids as intermediates of head morphogenesis of bacteriophage T3.


Research at the Burden Neurological Institute, Bristol.


A DNA-binding form of the main structural protein of lambda heads.


A mutant of Escherichia coli K12 unable to support the multiplication of bacteriophage BF23.


Alkaline hydrolysis of oligoribonucleotides on chromatographic paper.


Use of the cellscan-GLOPR system in the automatic identification of white blood cells.


The mite and house dust allergy. A review of current knowledge and its clinical significance.


Childhood status asthmaticus revisited. A synopsis of a program for management of childhood patients.


Delayed hypersensitivity and cell-mediated immunity. A survey of current insights into these responses of the body to antigens.


Managing cerebrovascular disease of the extracranial vessels: the ophthalmologist's role.


Keeping the elderly in the community and out of institutions.


Surgery for atherosclerosis of the extracranial arteries.


A Guy's-Maudsley special out-patient clinic: evolution from January 1956 to September 1971.


The bagnio of St Thomas's Hospital.

The bagnio of St Thomas's Hospital.


Interactions between macrophages of guinea pigs and salmonellae. 3. Bactericidal action and cytophilic antibodies of macrophages of infected guinea pigs. The fate of virulent Salmonella typhimurium within macrophages of guinea pigs was assessed by a suspended cell culture procedure. The present study confirmed that macrophages of normal guinea pigs were capable of inactivating the ingested salmonellae. Macrophages of previously infected guinea pigs were not endowed with any significant increase in their ability to eliminate the ingested pathogen. However, the immune macrophages were observed to clump together tightly when they were exposed to salmonellae. This phenomenon was attributed to the presence of specific cytophilic antibodies on the immune macrophages. When immune macrophages were inactivated with Merthiolate, they agglutinated with both the H and the O antigens of S. typhimurium, but not with the O antigens of other species of Salmonella nor with the O antigens of Escherichia coli. Cytophilic antibodies could be eluted from immune macrophages by incubation in the absence of immune serum. Conversely, cytophilic antibodies could be passively transferred onto normal macrophages by incubation in the presence of immune serum. Furthermore, using immune serum previously adsorbed with the O antigens of S. typhimurium, cytophilic antibodies against the H antigens alone could be transferred onto normal macrophages, or those against the O antigens alone could be eluted from immune macrophages. These data suggest that immune macrophages possess specific cytophilic antibodies against both the H and the O antigens of S. typhimurium. It is proposed that the presence of cytophilic antibodies on immune macrophages represents an expression of antibacterial cellular immunity by enhanced clumping and phagocytic activities of the macrophages.


In vitro migration of human alveolar macrophages: effects of cigarette smoking. The responsiveness of alveolar macrophages lavaged from healthy volunteers to migration inhibitory factor (MIF) was tested by using the capillary-tube assay method. In every instance, macrophages from nonsmokers responded to MIF as demonstrated by a depression in migration of at least 30%, whereas MIF did not inhibit migration of macrophages from smokers. Cells from smokers migrated at a rate three times faster than cells from nonsmokers. Migration of macrophages from nonsmokers with delayed hypersensitivity skin reactions to Candida albicans antigen was inhibited when antigen was present in the tissue culture medium. Antigen did not inhibit macrophages from subjects who lacked delayed hypersensitivity to the antigen, or from subjects who were cigarette smokers. Since alveolar macrophages can respond to MIF in vitro, they may play a role in cell-mediated immune reactions in the lung. Cigarette smoking may interfere with this participation.


Outer envelope of virulent Treponema pallidum. Ultrathin sections of virulent Treponema pallidum (Nichols strain) were examined with the electron microscope, and the presence of an outer cell envelope was documented.


Preliminary characterization of "immunogenic" ribonucleic acid derived from rat peritoneal exudate cells. An "immunogenic" ribonucleic acid (Im-RNA) has been extracted from peritoneal exudate (PE) cells of rats that were immunized with sheep erythrocytes (SRBC). Following multiple phenol extractions and deoxyribonuclease treatment, the material obtained from PE cells was eluted from diethylaminoethyl-cellulose at 0.55 M NaCl concentration and partially purified in this procedure by a factor of 7- to 10-fold. After column chromatography, Im-RNA was found to be free of antigen based on results using (51)Cr-labeled SRBC or (14)C-dinitrophenol coupled to methylated bovine serum albumin as antigens. The Im-RNA showed a biphasic hyperchromicity curve when heated. The first phase, from 30 C to 90 C was gradual, accounting for 15.2% hyperchromicity suggestive of transfer RNA melting. No loss in immunogenic activity was observed when the Im-RNA was heated to 90 C. The second phase, from 90 C to 102 C, accounting for 15.2% further hyperchromicity, had a calculated T(m) of 96 C. Heating above 90 C resulted in an irreversible loss of immunogenic activity. These results strongly suggested that the RNA fraction contained a highly ordered secondary structure such as might be found with double-stranded nucleic acid. The nature and function of the Im-RNA is discussed.


Howard James Curtis, 1906-1972.

Howard James Curtis, 1906-1972.


On the corrosion products of orthopedic implants.


The fractionation of yeast tRNA and proteins on nucleoside derivatives of cellulose.


Uniform distribution and concentration of aminopeptidase in proximal tubules of pig kidney.


Harry Steenbock (1886-1967)--a biographical sketch.


A short assay for the estimation of dietary purine compounds, using a rat model system with inhibition of uricase.


Obstructive uropathy caused by ureteral candidiasis.


Stimulation of prostatic antibodies by cryosurgery.


Urinary tract infection. Practical aspects of diagnosis and treatment.


Puerperal fever with Haemophilus vaginalis septicemia.


The double-blind dilemma.

The double-blind dilemma.


Serratia arthritis. Medical eradication of infection in a patient with rheumatoid arthritis.


Geoffrey Rourke Welsford Latham.

Geoffrey Rourke Welsford Latham.


Leslie Abramovich.

Leslie Abramovich.


The incomplete darkfield transillumination: a complementary vitalmicroscopic technique.


Physical and biological properties of acetamidino-, beta-dimethylaminopropionamidino-, and maleyl-L-asparaginase.


Carrier-mediated transfer of amino acids from blood to brain. An in vivo study in the rat.


P-O-methylation of protocatechuic acid, a metabolite of epinephrine and norepinephrine, in perfused rat liver.


Obesity, islet function and diabetes mellitus.


Synthesis of a decapeptide with the biological activity of porcine LH releasing hormone.


Interaction of prostaglandins and LH-RH in vitro.


Influence of steroid hormones on the response to LH-RH in the eye-ovary-transplant of the rabbit.


Response of plasma LH in male pigs to synthetic LH-FSHRH.


Plasma prolactin levels in the male rat after pituitary injection of LH-RH.


Pituitary reserve capacity and pituitary responsiveness to LH-RH during the estrus cycle in sheep.


Evidence for partial refractoriness of the human pituitary.


Hormonal response to multiple stimulation with synthetic luteinizing hormone-releasing hormone (LH-RH) in amenorrhoic women.


The diagnostic use of synthetic LH-RH (HOE 471) in women with normal and disturbed menstrual function and under treatment with sex-steroids.


LH-RH-test of pituitary function in ovarian insufficiencies.


Therapeutic aspects of LH-RH in ovarian insufficiency.


The effect of intravenously infused synthetic LRH on LH, testosterone and dihydrotestosterone in the plasma of normal male subjects.


The effects of LH-RH infusion on plasma concentrations of LH, testosterone and cortisol in the male.


LH-secretion after synthetic LH-RH in the male under normal and pathological conditions.


Fatal necrotizing fasciitis developing after tooth extraction.


ICSH(LH) and FSH levels in plasma after i.v. administration of LH-RH in impaired gonadal function.


Rat hepatic glucokinase: improved purification and some properties.


Effect of proxazole on total and regional cerebral blood flow.


Modification of lysine residues of pepsinogen with dicarboxylic anhydrides.


Biochemical characterization and messenger specificity of polypeptide chain initiation factors from Escherichia coli.


Double-blind comparison of ibuprofen and phenylbutazone in a short-term treatment of rheumatoid arthritis.


A comparison of phenylbutazone and indometacin in the treatment of rheumatoid arthritis.


Guanethidine and adrenaline used in combination in chronic simple glaucoma.


A cell population study of IgM affinity maturation.


Specific immunosuppression by passive antibody. IV. Mechanism of reversal by spleen or peritoneal exudate cells from immune animals.


Fractionation of mouse T and B lymphocytes by preparative cell electrophoresis. Efficiency of the method.


Blocking of delayed hypersensitivity by humoral antibody in an in vivo mouse transfer assay using sensitized guinea pig cells.


The significance of dermatoglyphics in medicine. A short survey and summary.


Prevention of rheumatic fever. A comparative study of clindamycin palmitat and ampicillin in the treatment of group A beta hemolytic streptococcal pharyngitis.


Clinical trial of methyl clofenapate (a derivative of clofibrate) in patients with essential hyperlipidaemias--with special reference to type II (primary) hyperlipidaemia.


Controlled trial of clofibrate in cerebral vascular disease.


Bone mineral on the molecular level.

Bone mineral on the molecular level.


Relationship of pesticides to immune responses.


Analogs of luteinizing hormone-releasing hormone containing derivatives of phenylalanine in place of tyrosine.


An antilactogenic effect of pyridoxine.

An antilactogenic effect of pyridoxine.


The effect of antibacterial drugs on the ultrastructure of Mycobacterium leprae in human skin.


Demonstration of Mycobacterium leprae and its viability in the peripheral blood of leprosy patients.


Carbohydrate metabolism in uremia: a review.


Fungemia caused by torulopsis glabrata.

Fungemia caused by torulopsis glabrata.


The E. coli cell surface: on the genetic organization of the tolPAB cluster.


Efficacy and safety of metolazone in renal failure and the nephrotic syndrome.


A slow-growing, ribosomal mutant of Salmonella typhimurium.


Incisions in ultraviolet irradiated circular bacteriophage lambda DNA molecules in excision proficient and deficient lysogens of E. coli.


The specificity of transcription in vitro of the trp operon of Escherichia coli.


A controlled replication of the effectiveness of diphenylhydantoin in reducing irritability and anxiety in selected neurotic outpatients.


New members of The New York Academy of Sciences.


Testosterone in plasma. A physiopathological study.


Marinus Anton Donk (1908-1972).

Marinus Anton Donk (1908-1972).


Isolation of thermophilic fungi from alligator nesting material.


Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients.


Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat.


Patterns of nuclear fluorescence and DNA-binding activity.


Controlled trial of penicillamine in severe rheumatoid arthritis.


Biochemical properties of yeast L-asparaginase.


Axial and random pattern flaps.

Axial and random pattern flaps.


Prefabrication techniques in cervical pharyngo-oesophageal reconstruction.


Metabolically active, single cell preparations from the mucosal epithelium of rabbit small intestine.


Ureteric reflux 1973: chronic pyelonephritis v. reflux nephropathy.


Isolation of a non-collagenous reticulin component and its primary characterization.


The original Z-plasty.

The original Z-plasty.


Radiological diagnosis of foetal foregut abnormalities.


The usefulness of computerized transverse axial scanning in problems arising from cerebral haemorrhage, infarction or oedema.


Attempt to protect rabbits against experimental syphilis by passive immunization.


Immunological studies on treponemal cellular antigens. I. Serological changes and resistance to infection in rabbits immunized with treponemal nucleic acids.


Fluorescent treponemal antibody tests on cerebrospinal fluid.


Treatment of gonorrhoea with procaine penicillin plus probenecid.


Control of moderately raised blood pressure. Report of a co-operative randomized controlled trial. A study was designed to investigate the effect on morbidity and mortality of lowering diastolic blood pressure levels of between 100 and 120 mm Hg to below 100 mm Hg. Fifty-eight men and women, aged from 45-69 years, with blood pressure levels between 100 and 120 mm Hg were matched for age, sex, and blood pressure levels with 58 control patients. The maintenance of diastolic blood pressures at levels below 100 mm Hg was successfully carried out without serious drug side effects. Treatment effectively maintained diastolic pressures below 100 mm Hg, but no effect was shown on other terminating events. Few problems were found in the management of patients with minimally raised blood pressure, most of whom were symptom-free. The treatment and control groups became less comparable as increasing numbers of patients in the control group were withdrawn from the trial as diastolic pressures rose above 130 mm Hg.


Delayed attacks of malaria in visitors to the tropics. Out of 80 Danish college students and their teachers visiting the Middle East, West Pakistan, and India by bus in two four-month journeys during the summer and autumn of 1971, six individuals developed an apparently first attack of vivax malaria within seven to nine months after their return to Denmark. No cases of malaria were seen in the group during the journeys. Prophylaxis with chloroquine (Resochin) was strictly observed when visiting the areas in which malaria is endemic.All cases responded rapidly and completely to a full course of treatment with chloroquine. The most probable cause of the delay of the clinical manifestations is drug prophylaxis, which can prevent a clinical attack but not always eradicate the parasite.


J. Forest Smith.

J. Forest Smith.


Phillis Dingle.

Phillis Dingle.


Sir Walter Chiesman.

Sir Walter Chiesman.


S.A. Waksman.

S.A. Waksman.


Prosthetic valve endocarditis. Analysis of 38 cases.


The effects of atrial pacing on the synergy and hemodynamics of the orthotopically transplanted canine heart.


Of the principles of investigation in physiology: a preface to "Memoirs of Marshall Hall", 1861.


Comparative evaluation of sublingual long-acting nitrates.


The bacteriology of the stools of children admitted to Kenyatta National Hospital suffering from diarrhoea.


Haemagglutinating and immunofluorescent autoantibodies in ischaemic heart disease.


Experimental and clinical study with endotoxin shock.


Resistance to Taenia pisiformis larvae in rabbits. II. Temporal relationships and the development phase affected.


Growth in vitro of Trypanosoma cruzi as amastigotes at temperatures below 37degrees C.


Isolation and characterization of an endonuclease from Escherichia coli specific for ribonucleic acid in ribonucleic acid-deoxyribonucleic acid hybrid structures.


The cysteine desulfhydrase of Salmonella typhimurium. Kinetic and catalytic properties.


Aspartate transcarbamylase from Escherichia coli. The use of pyridoxal 5'-phosphate as a probe in the active site.


Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupolar relaxation studies of the role of bound zinc.


Interaction of aspartate transcarbamylase with regulatory nucleotides.


The stoichiometry and kinetics of the inducible cysteine desulfhydrase from Salmonella typhimurium.


The induction of arginase in Saccharomyces cerevisiae.


The induction of urea carboxylase and allophanate hydrolase in Saccharomyces cerevisiae.


Escherichia coli Co(II) alkaline phosphatase. Absorption, circular dichroism, and magnetic circular dichroism of the d-d electronic transitions.


Low-resistance pathways between mitotic and interphase epidermal cells in vitro.


The organization of yeast nucleohistone fibers.


Clinical applications of the luteinizing hormone-follicle-stimulating releasing hormone.


Neural mechanisms of pituitary control.

Neural mechanisms of pituitary control.


Studies in the use of luteinizing hormone-follicle-stimulating hormone releasing hormone to induce ovulation in women.


Effects of oral inoculation of Candida albicans in tetracycline-treated rats.


Mechanism of production of candida lesions in rabbits.


Sensitivity of yeasts to 5-fluorocytosine.


Chloramphenicol resistance in Escherichia coli.


Helen Aitken Wright, 13 April 1895-27 August 1972.


Toxoplasmic lymphadenitis in Iran.

Toxoplasmic lymphadenitis in Iran.


Severe reaction to the bite of the triatomid bug (Triatoma rubrofasciata) in Singapore.


Situs inversus with amoebic liver abscess.


Tetanus in Lagos: a review of 228 adult Nigerian patients.


Sir James Cantlie (1851-1926). Founder of the Journal of Tropical Medicine.


The Liverpool School of Tropical Medicine--the first 75 years.


The Royal Naval contribution to a "Strange Pathology".


1898--Annus mirabilis in the history of malaria.


Seventy-five years old--The Journal of Tropical Medicine and Hygiene.


A survey of growth hormone secretion and action.


Identification of new genes involved in disaccharide fermentation in yeast.


Strand-specific DNA degradation in a mutant of Escherichia coli.


Genetic and biochemical evidence of sucrose fermentation by maltase in yeast.


Mitochondrial genetics. 3. Recombined molecules of mitochondrial DNA obtained from crosses between cytoplasmic petite mutants of Saccharomyces cerevisiae: physical and genetic characterization.


Isolation and characterization of a temperature-sensitive amber suppressor mutant of Escherichia coli K12.


Spontaneous whole brain slow potential changes during recovery from experimental neurosurgery. Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motility. The method used in this study provides a tool for evaluating recovery from neurosurgical trauma or other brain injuries, and for testing procedures that facilitate or impede this process.


The density of Azotobacter in root-free soils and in the rhizosphere of several plants in arid and semi-arid Libyan regions.


Studies in actinomycetes in Egyptian soils. I. The distribution of actinomycetes.


Studies in humic acids decomposing bacteria in soil. II. Isolation and identification of micro-organisms.


Tetracyclines.

Tetracyclines.


A simple medium for quick growth of Rhizobium japonicum.


Occurrence of clostridia in white pickled Domiati and Gouda cheeses.


Evaluation of Bacto-strip technique for the detection of coliforms in pasteurized milk.


The viability of Salmonella typhimurium in ice-cream.


Dye dilution technique with angiography in the investigation of renal arteriovenous shunting.


Differences of current-desired activities of accepted and rejected educable mentally retarded boys.


Urography with urea wash-out in renovascular hypertension. A comparison with split renal function tests and predictive value.


Experience with closed circuit television in the blind rehabilitation program of the Veterans Administration.


Kinetics of unidirectional glucose transport into the isolated dog brain.


Early effects of cortisol on glucose and alanine metabolism in adrenalectomized sheep.


Positive end-expiratory pressure in refractory hypoxemia. A critical evaluation.


Digitalis glycosides. Pharmacokinetics and their clinical implications.


Effect of drug treatment for lymphoma on male reproductive capacity. Studies of men in remission after therapy.


Prostaglandins: therapy for peptic ulcer?


Conflict resolution by septal, dorsal hippocampal or ventral hippocampal lesioned rats with pre- or post-operative approach training.


Carbazochrome salicylate as a parenteral hemostat in tonsillectomy.


Fundoplication alone will not prevent the recurrence of a hiatus hernia: a case report.


Major Sir Frederick Thomas George Hobday C.M.G., F.R.C.V.S., F.R.S.E. 1870-1939. Man, surgeon and principal of the Royal Veterinary College.


A way for fluorescence histochemical studies of noradrenaline nerve fibers in the vagus nerve: the air-dried split nerve preparation.


Perception of violence as a function of levels of hostility.


Solubilization of HL-A antigens from peripheral blood leukocytes.


The projected self-concept scale.

The projected self-concept scale.


Surface immunoglobulins of circulating lymphocytes in mouse plasmacytoma. 3. The effect of plasmacytoma RNA on the immune response.


Eliciting effects of verbal and nonverbal cues on projective test responses.


Clinical cardiology. Computers and cardiovascular medicine.


Current methodologies for studying the development of schizophrenia: a critical review.


The offspring of schizophrenic parents: a review.


Involvement of DNA polymerase 3 in excision repair after ultraviolet irradiation.


Role of DNA polymerase II in repair replication in Escherichia coli.


Effects of chemoattractants on the motility of Escherichia coli.


Bachelor's disease. Etiology, pathology, and treatment of spermatorrhea in the nineteenth century.


Havelock Ellis. Sexologist and voyeur.

Havelock Ellis. Sexologist and voyeur.


Procedure of conducting the host-mediated assay utilizing bacteria ("Salmonella typhimurium").


Critique of in vivo cytogenetic test systems.


Cytogenetic techniques in mutagenicity testing.


Metabolic activation of mutagens in mammals host-mediated assay utilizing the induction of mitotic gene conversion in Saccharomyces cerevisiae.


The host-mediated mammalian cell assay.

The host-mediated mammalian cell assay.


Preparation for simple bridgework. I.

Preparation for simple bridgework. I.


The restoration of fractured incisors by the acid-etch technique.


Lip splinting in a case of Bell's palsy.


Preparation for simple bridgework. II.

Preparation for simple bridgework. II.


Cultivation of parasitic leptospires: effect of pyruvate. Sodium pyruvate (100 mug/ml) is a useful addition to the Tween 80-albumin medium for the cultivation of parasitic serotypes. It is most effective in promoting growth from small inocula and growth of the nutritionally fastidious serotypes.


Some observations on the incorporation of novobiocin into Hektoen enteric agar for improved Salmonella isolation. Novobiocin was incorporated into Hektoen enteric agar as a means of suppressing those Proteus and Citrobacter organisms that produce colonies which are often mistaken for Salmonella.