Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial. The bone mineral mass was estimated by photon absorptiometry in 23 epileptic patients on long-term treatment with phenytoin and in 20 normal subjects before and during treatment with vitamin D or placebo.Initially, subnormal values of bone mineral mass were found in the epileptic patients. The group of epileptic patients treated with vitamin D showed a significant increase in bone mineral mass. The group of epileptic patients treated with placebo and the normal subjects treated with vitamin D or placebo showed no change in bone mineral mass.


Outpatient maintenance of chronic schizophrenics with long-acting fluphenazine.


B. Barling.

B. Barling.


J.D.J. Freeman.

J.D.J. Freeman.


W.A.M. Smart.

W.A.M. Smart.


F.C. Chesterman.

F.C. Chesterman.


W.H. Patterson.

W.H. Patterson.


David Livingstone. 1813-1873.

David Livingstone. 1813-1873.


A.L. Alban.

A.L. Alban.


Experience with mass drug administration as a supplementary attack measure in areas of vivax malaria. Mass drug administration was introduced in Syria to supplement DDT spraying after the main malaria vector Anopheles sacharovi had developed considerable resistance to the insecticide. Mass administration of weekly doses of chloroquine and pyrimethamine was carried out in the Ghab area from August to October, the coverage obtained being over 80% for most of the time. The number of cases with positive blood films declined rapidly from August onwards. Entomological observations showed that the house-resting density decreased shortly after the second round of DDT spraying but soon regained its previous level. Some relapsing cases were detected in 1969 but none were found in 1970, and it is considered that the possibility of relapses should not deter authorities from using mass drug administration in emergency situations.


Red blood cell morphology in falciparum malaria. The morphology of the erythrocyte in Plasmodium falciparum infection is still obscure. In a study of 27 cases, uninfected erythrocytes were found to be thinner, but greater in diameter and surface area, than such cells in 10 normal individuals. The changes were not correlated with the severity of the disease or the degree of reticulocytosis. Megaloblastic anaemia was not present in the malaria cases.


Kidney autotransplantation for ureteral loss from granulomatous colitis.


A pilot study of medicare patients' experiences and attitudes. There has been widespread interest in the effect the Medicare law has had on the level of physicians' charges. This subject and other aspects of the present Medicare method of physician reimbursement is currently under study by Congress and the Department of Health, Education and Welfare. A group of Medicare patients recently seen and treated by the author were queried as to their experiences in paying for physicians' services under Medicare. A 64 percent response rate and the substance of the replies to a questionnaire suggests that this is a feasible mechanism for eliciting the attitudes and problems in a group of patients in the Medicare program.


Cellular proliferation in carcinogenesis.


LH and FSH releasing potency of the synthetic decapeptide p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH 2 in human beings.


Current transfusion therapy.

Current transfusion therapy.


Dynamic synthesis and release of insulin and proinsulin from perifused islets.


Mitochondrial genetic analysis by zygote cell lineages in Saccharomyces cerevisiae. Yeast strains were constructed carrying multiple mitochondrial markers conferring resistance to the inhibitors erythromycin, chloramphenicol, paromomycin and oligomycin. A pedigree analysis of two crosses was made by micromanipulating buds from zygotes. The first few daughter buds isolated from the zygotes sometimes gave rise to diploid clones which had a mixture of mitochondrial types. All possible classes of mitochondrial parental and recombinant types were found although they never appeared all together as the progeny from a single zygote. It was inferred that multiple recombination events took place in zygotes and in some of the buds derived from them. After removal of the first four or so daughter buds, subsequent buds from the zygote carried one mitochondrial type only. In cross I in which three markers were analyzed this was most frequently one of the parental types. In cross II (involving four mitochondrial markers) the later buds from the zygotes were frequently of recombinant mitochondrial type.


Lysergic acid diethylamide: its effects on human chromosomes nd the human organism in utero. A review of current findings.


Opiate addiction in the late nineteenth century: a study of the social problem, using medical journals of the period.


Tubal sterilization without visible scar.


Trichobezoar: case presentation and review of literature.


Posttraumatic atlantoaxial instability: the fate of the odontoid process fracture in 46 cases.


Clinical evaluation of Epigard, a new synthetic substitute for homograft and heterograft skin.


The historical background of acupuncture.


Health screening for medical children.

Health screening for medical children.


Functional homology between the 30S ribosomal protein S7 from E. coli K12 and S7 from E. coli MRE600.


Sensitivity of Escherichia coli to viral nucleic acid. VI. Capacity of dna mutants and DNA polymerase-less mutants for multiplication of phiA and phiX 174.


The functional and structural homology of ribosomal protein S7 of E. coli strains K and MRE600.


Biogenesis of mitochondria. 30. An analysis of polarity of mitochondrial gene recombination and transmission.


A ne type of alkaline phosphatase-negative mutants in Escherichia coli K12.


Mutagenic action of hydroxylamine and methoxyamine on yeast. II. Methoxyamine.


Mutagenic action of hydroxylamine and methoxyamine on yeast. I. Hydroxylamine.


Evidence for differing modes of interaction of acriflavine with ultraviolet-induced lesions in an Hcr +  bacterial strain.


Transport of impermeant substances in E. coli by way of oligopeptide permease.


TYMV RNA as a substrate of tRNA maturation endonuclease.


TYMV valyl-RNA as an amino-acid donor in protein biosynthesis.


Endonuclease activity toward DNA irradiated in vitro by gamma rays.


Bacterial hydrolases and aldolases in evolution.


Characterization of the mRNA transcribed from the head and tail genes of phage lambda chromosome.


Factor 8 on the vascular intima: possible importance in haemostasis and thrombosis.


Release of luteinizing hormone by oestradiol-17  and a gonadotrophin-releasing hormone in ewes affected with clover disease.


Synthesis and turnover of cell membranes.


Hexachlorophene and the control of staphylococcal sepsis in a maternity unit in Geelong, Australia.


Micropreparative equilibrium density centrifugation in the analytical centrifuge.


Mycotoxins in foodstuffs and their biological action on mammals.


The estimation of polypeptide chain molecular weight by thin-layer gel filtration in urea and sodium dodecyl sulphate solution.


A clinical trial of treatment in early breast cancer.


Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease.


Observer variation in clinical diagnosis: its magnitude and importance in patients with acute abdominal pain.


The early diagnosis of rejection by the leucocyte migration test in cadaveric renal transplantation.


Profound childhood deafness. Inner ear pathology.


Measurement of lymphocyte activity in response to a renal allograft.


The mechanism of enhancement of rat renal allografts. The nature of enhancing antibody.


Antibody-induced enhancement of cardiac allografts in mice.


The character of effector cells and the accumulation of macrophages in rejecting heart allografts in the rat.


Early intracranial pressure and blood-flow measurements in cerebral gunshot wounds.


Early photography, goitre, and James Inglis.


J.F. Wilde.

J.F. Wilde.


F. L. Cole.

F. L. Cole.


M.H. Barton.

M.H. Barton.


A.R. Fisher.

A.R. Fisher.


L.F. Evans.

L.F. Evans.


Sir Clement Price Thomas.

Sir Clement Price Thomas.


Yeasts on skin.

Yeasts on skin.


Interaction between levodopa and methyldopa. The interaction between methyldopa and levodopa was studied in 18 patients with Parkinsonism. Together they produced a fall in blood pressure in doses which when given alone had no effect or only a slight hypotensive effect. Severe hypotension never occurred. It is reasonable to give methyldopa to hypertensive patients on levodopa but the regimen should be initiated in hospital.


Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis. The effects of phenformin and ethyloestrenol and phenformin and stanozolol on the clinical state, plasma fibrinolytic activity, and fibrinogen-fibrin-related antigen (F.R.-antigen) were compared with placebo in 13 patients with cutaneous vasculitis. Eight patients showed considerable clinical improvement when taking phenformin and an anabolic steroid; an impaired fibrinolytic activity before treatment favoured clinical improvement.


Affinity chromatography of phenylalanine:tRNA ligase.


Studies on the interchain disulfides of human haptoglobins.


ICMSF methods studies. I. Comparison of analytical schemes for detection of Salmonella in dried foods.


A temperature-sensitive glycyl-transfer ribonucleic acid synthetase mutant of Escherichia coli.


Professor Venancio Deulofeu.

Professor Venancio Deulofeu.


Effect of uridine on the incorporation of thymine and thymidine in Escherichia coli.


In memoriam Alex E. Krill.

In memoriam Alex E. Krill.


The cone degenerations.

The cone degenerations.


Relationship between immune response to gram-negative intestinal rods and allotransplantation reaction.


Changes in circulating blood of irradiated mice following bone marrow transplantation.


Comparison of immunosuppressive effectiveness of chloramphenicol and thiamphenicol on allotransplantation reaction in mice.


Liver transplantation in man: the frequency of rejection, biliary tract complications, and recurrence of malignancy based on an analysis of 26 cases.


The effect of perfusion on the flora of the excluded colon. The bacterial flora of excluded colonic segments of three patients has been examined in the normal resting state and following perfusion.The flora of the excluded colon was substantial and qualitatively similar to that of faeces. Perfusion for two hours at 10 ml per minute usually reduced counts of organisms present in the issuing effluent by 1 to 1(1/2) logs in two patients, but rises in the counts of some organisms were recorded from the third patient. Prolonged rapid perfusion or the inclusion of antibiotics in the perfusing solution was necessary to obtain a substantial reduction in counts. Rapid perfusion resulted in the appearance of organisms that had not been recovered during slower perfusions.


Ammonia production by intestinal bacteria. Bacterial growth and the production of ammonia from urea and by deamination of peptone has been examined at various pHs in both conventional static bacterial cultures and in a continuous cultivation system. Growth occurred on primary testing of 93 out of 100 strains of aerobic Gram-negative bacteria at pH 5, and 48 out of 50 strains of Esch. coli at pH 4.6. Hydrolysis of urea by Proteus mirabilis decreased steadily from pH 7.2 to pH 5.3; below pH 5.3 little hydrolysis occurred. Ammonia production from peptones by Esch. coli decreased from pH 7.2 to pH 4.6. Considerable variation was noted in the ability of different strains to produce ammonia. Experiments with cultures containing both Esch. coli and Pr. mirabilis showed that more ammonia was produced at low pH than was produced by cultures of single organisms. At low pH reduction in the count of organisms was not found to be an essential prerequisite for reduction of ammonia formation.


Symposium on gastrooesophageal reflux and its complications. 6. Surgical treatment.


Hypothalamic follicle-stimulating-hormone-releasing factor content in the female rat before and after puberty.


Sequence of bovine liver glutamate dehydrogenase. VII. Isolation and sequences of peptic peptides.


Initiation of protein synthesis in vitro by a clostridial system. I. Specificity in the translation of natural messenger ribonucleic acids.


Initiation of protein synthesis in vitro by a clostridial system. II. The roles of initiation factors and salt-washed ribosomes in determining specificity in the translation of natural messenger ribonucleic acids.


Stimulation of lac transcription by guanosine 5'-diphosphate 2'(or 3')-diphosphate and transfer ribonucleic acid.


Dynamics of insulin release and microtubular-microfilamentous system. I. Effect of cytochalasin B. In order to assess the participation of the microfilamentous cell web in the multiphasic response of the pancreatic beta cell, the effect of cytochalasin B upon both glucose- and sulfonylurea-induced insulin release was investigated in the perfused isolated pancreas. Cytochalasin B failed to affect the basal rate of insulin release, but enhanced the initial and later phases of insulin secretion in response to either glucose or gliclazide. In addition, cytochalasin B lowered the threshold concentration for the stimulant action of glucose upon insulin release. Ultrastructural studies supported the concept of a specific interaction of cytochalasin B with the microfilamentous cell web of the beta cell. It is concluded that the integrity of such a structure is equally important for both the initial and later secretory responses of the beta cell to various insulinotropic agents.


Evidence suggesting persistence of nephritogenic immunopathologic mechanisms in patients receiving renal allografts. Direct immunofluorescent (IF) examinations and elutions were performed on native kidneys and allografts of 24 patients undergoing renal transplantation. Immunoglobulins (Ig) were detected by IF on native kidneys of 12 of the 24; 11 of the 12 later had Ig localized to allograft glomeruli by direct IF. In addition, three other patients also developed Ig deposition on allograft glomeruli, although direct IF of native kidneys was negative. Elution studies indicated: (a) that linear Ig deposition on allograft glomeruli was the result of antiglomerular basement membrane (GBM) antibodies, (b) Ig localizing to allograft glomeruli in many of these patients was the result of persistent immunopathogenetic mechanisms existing at the time of allograft placement, and (c) occasionally, kidneys negative for Ig localization by direct IF contain elutable nephritogenic antibodies.


On the uptake of materials by the intact liver. The concentrative transport of rubidium-86. In this study we use the multiple indicator dilution technique to outline the kinetic mechanisms underlying the uptake of rubidium, a cation which, in the steady state, is concentrated by hepatic parenchymal cells. We inject a mixture of (51)Cr-labeled red blood cells (a vascular reference substance), (22)Na (which is confined to the extracellular space, the expected extravascular distribution space for rubidium, in the absence of cellular uptake), and (86)Rb into the portal vein and obtain normalized outflow patterns, expressed as outflowing fractions of each injected mass per milliliter vs. time. The labeled red cell curve rises to the highest and earliest peak and decays rapidly. That for labeled sodium rises to a later and lower peak, and decays less rapidly. Its extrapolated recovery is equal to that for the red cells. The observed (86)Rb curve consists of two parts: an early clearly defined peak of reduced area, related to the (22)Na peak in timing; and a later tailing, obscured by recirculation, so that total outflow recovery cannot be defined (even though it would be expected to be the same). We model the concentrative uptake of (86)Rb and find two corresponding outflow fractions: throughput material, which sweeps past the cell surface as a wave delayed with respect to the vascular reference (tracer which has not entered cells); and exchanging material (tracer which has entered cells and later returns to the circulation). We find that the outflow form of the rubidium curve, the presence of both a relatively clearly defined throughput component and a relatively prolonged low-in-magnitude tailing, is consequent to the concentrative character of the transport mechanism, to the presence of an influx rate constant many times the efflux rate constant. The modeling which we develop is general, and has potential application in situations where transport is nonconcentrative.


The complement system in bullous pemphigoid. I. Complement and component levels in sera and blister fluids. Compared with other serum and blister fluid proteins, total hemolytic complement was reduced in the blister fluid of six serologically positive bullous pemphigold patients while four serologically negative cases had blister fluid complement levels closely approaching the serum levels. Except for pemphigus vulgaris blisters. blister fluids from most patients with other bullous diseases and experimentally induced blisters had blister fluid complement levels more closely approaching the serum levels. With the exception of the two terminal components. C8 and C9, individual components of the complement sequence were also reduced in the blister fluids of the six bullous pemphigold patients with circulating basement membrane zone antibodies. On the other hand, transferrin and IgG levels of these same six serologically positive blister fluids closely approached the corresponding serum levels. Conversion of C3 proactivator was also demonstrable in the serologically positive bullous pemphigoid blister fluids, but not in the corresponding sera. Our studies, therefore, are suggestive of local activation of the complement sequence, by both the classical and alternate pathways, in blisters of serologically positive bullous pemphigold patients.


On the uptake of materials by the intact liver. The transport and net removal of galactose. D-galactose, a monosaccharide rapidly phosphorylated within liver cells, is irreversibly removed from the portal circulation. We have studied the kinetic relations between the hepatic cell entry process and the metabolic sequestration process, by means of the multiple indicator dilution technique. Labeled red blood cells (a vascular indicator), labeled sucrose (an extracellular reference), and labeled galactose were rapidly injected into the portal vein, and from rapidly sampled hepatic venous blood, normalized outflow-time patterns were secured. The labeled red cell curve rises to the highest and earliest peak, and decays rapidly; and that for labeled sucrose rises to a later and lower peak. Its extrapolated recovery is equivalent to that of the labeled red cells. At low blood galactose concentrations, the labeled galactose appears at the outflow with labeled sucrose, but is much reduced in magnitude, and exhibits a long tailing. Its outflow recovery is much reduced. At high blood galactose concentrations, the initial part of the profile increases towards that for labeled sucrose, the tailing becomes much larger in magnitude, and the outflow recovery becomes virtually complete. We have modeled the uptake of labeled galactose, and find two parts to the predicted outflow pattern, corresponding to our experimental observations; throughput material, which sweeps past the cell surface in the extracellular space; and returning material, which has entered the cells but escaped the sequestration process. Analysis of the data by use of this model provides estimates of both transmembrane fluxes and rates of sequestration. The capacity of the process subserving cell entry is found to be 40 times that for phosphorylation; and, whereas the K(m) value for sequestration is less than 15 mg/100 ml, that for entry is approximately 500 mg/100 ml. Both processes are relatively stereospecific; the entry of the L-stereoisomer is very slow and it undergoes no significant amount of metabolic sequestration. The sequestration process produces a lobular intracellular concentration gradient; and this gradient, in turn, produces some uncertainty in the estimate of the true K(m) value for the sequestration process.


A controlled trial of the use of dip slides in general practice for the diagnosis of urinary infection. A controlled trial of the use and interpretation of dip-inoculation slides for the diagnosis of urinary infection in four general practices is reported. Two slides were inoculated from each specimen, one being incubated and read in the surgery by the practitioner, the other being sent to the laboratory for incubation and interpretation. It is shown that the presence or absence of bacteriuria can be detected with a high degree of accuracy by a surgery procedure. The implications for the laboratory, the patient, and the practitioner are discussed. It is suggested that the financial saving on laboratory time and unnecessary treatment would far outweigh the outlay on apparatus and materials, and that many patients would benefit from the accurate diagnosis of urinary infection which, for a variety of reasons, is at present denied them.


The role of the mesangial cell in proliferative glomerulonephritis. In 40 patients with a histological diagnosis of proliferative glomerulonephritis the deposition of immunoglobulins, complement (C(3)), and fibrin/fibrinogen has been assessed by immunofluorescence and electron microscopy. The results of such examinations have been correlated with the outcome of the illness. In minor or resolving disease there is usually minor functional impairment, a good response to therapy or spontaneous resolution, the deposition of small amounts of material in glomerular capillary walls, and active mesangial removal. In moderate to marked disease there is initially a moderately severe functional disorder, a good response to therapy, considerable deposition of material in glomerular capillary walls but with less active mesangial regions than in the previous group. In progressive glomerulonephritis there was initial severe functional disorder, poor response to therapy, large amounts of material deposited within capillary walls, and active mesangial regions which were greatly enlarged, containing numerous deposits. In the rapidly progressive group there was severe functional disorder with poor response to therapy, the deposition of only small amounts of material within capillary walls, the lack of any significant mesangial cell reaction, and the formation of epithelial crescents. The results of the study indicate that in proliferative glomerulonephritis following the deposition of material in glomerular capillary loops, the progression of the disease is, to some extent at least, dependent upon the ability of the mesangial cell to remove such material.


The optical and electron microscopic determination of pulmonary asbestos fibre concentration and its relation to the human pathological reaction. The quantitative extraction of asbestos fibres from asbestotic lung by alkali digestion has been refined by maceration of the tissue without prior drying, the minimum use of centrifugation, and the adoption of phase contrast microscopy. Preliminary experiments suggested that, using this technique, asbestos fibre counts were accurate to within at least +/- 20% and in most instances to within +/- 10%. The method was used to assess asbestos concentrations in lung tissue showing various degrees and forms of fibrosis. The results, as determined by light microscopy, indicated that uncoated fibres generally outnumbered coated fibres. In mild and moderate asbestosis there was a progressive increase in concentration of asbestos fibres, both coated and uncoated, with increasing severity of fibrosis, whereas in severe asbestosis no correlation existed between the fibre concentration and the form or the extent of the pathological reaction. It is suggested that the severe fibrosis results from the supervention of non-specific inflammatory processes. Asbestos fibre diameter distributions, gauged by electron microscopy, were fairly constant irrespective of the degree of fibrosis. Optically visible fibres constituted between 12 and 30% of the total, so that an optical count may be said to give an approximate indication of the total asbestos concentration and, so far as asbestosis is concerned, may well serve for comparative purposes. The relation between asbestos and neoplasia will, however, require identification and quantitation of particular types of the mineral by microanalytical techniques.


Investigation of glial cells in semithin sections. 3. Transformation of subependymal cells into glial cells, as shown by radioautography after  3 H-thymidine injection into the lateral ventricle of the brain of young rats.


Synthesis of bacteriophage-coded gene products during infection of Escherichia coli with amber mutants of T3 and T7 defective in gene 1. During nonpermissive infection by a T7 amber mutant in gene 1 (phage RNA polymerase-deficient), synthesis of the products of the phage genes 3 (endonuclease), 3, 5 (lysozyme), 5 (DNA polymerase), and 17 (serum blocking power) was shown to occur at about half the rate as during wild-type infection. This relatively high rate of expression of "late" genes (transcribed normally by the phage RNA polymerase) seems to be a general feature of all T7 mutants in gene 1 from our collection. In contrast, T3 gene 1 mutants and a T7 gene 1 mutant from another collection showed late protein synthesis at very reduced rates. Synthesis of the gene 3 endonuclease by T7 gene 1 mutants was very sensitive to the addition of rifampin 2 min after infection, conditions under which there was very little inhibition during wild-type infection. This supports the notion that late gene expression during nonpermissive infection by gene 1 mutants is dependent on the transcription of the T7 genome by the host RNA polymerase. In contrast to T3 gene 1 mutants, the T7 gene 1 mutants of our collection directed the synthesis of phage DNA during nonpermissive infection. This DNA accumulated as a material sedimenting faster than mature T7 DNA.


Amber mutant of bacteriophage Q  capable of causing overproduction of Q  replicase. Amber mutant amB86 of bacteriophage Qbeta is capable of causing the production of five to eight times more viral replicase than wild-type phage. Su(-) bacteria infected with the mutant can carry the viral RNA in a plasmid-like state for many bacterial generations.


Effect of inhibition of macromolecule synthesis on the association of bacteriophage T4 DNA with membrane. The "Mg(2+)-Sarkosyl crystals" (M band) technique distinguishes between membrane-bound and free intracellular DNA. This procedure was employed to investigate the nature of the reactions necessary to convert input T4 DNA to a rapidly sedimenting form. Energy poisoning inhibits this attachment reaction. Neither protein nor DNA synthesis appears to be required, but experiments with rifampin and extensively irradiated T4 suggest that RNA synthesis is involved. These results were confirmed by a second procedure for the determination of rapidly sedimenting DNA.


Indirect fluorescent antibody test in experimental infection of Angiostrongylus cantonensis in rats.


Examination of the distribution of perorally administered lipopolysaccharide of Escherichia coli in conventional and germfree infant mice.


Degradation of tuberculoproteins by incubation with lysosomal components of the mouse spleen.


Presentation of the Distinguished Service Award to Russell A. Nelson, February 23, 1973.


Effects of hydrocortisone on the in vitro primary immune response of mouse spleen cells to sheep erythrocytes.


The presentation of a portrait of Dr. George G. Finney, February 23, 1973.


Z-closure.

Z-closure.


Raised intraocular tension in renal transplant recipients.


Primary reticulum cell sarcoma of the skull.


Robert Porter Welch, M.R.C.S., and his first Australian medical publication.


Robert James Jackson.

Robert James Jackson.


Marc Roger Playoust.

Marc Roger Playoust.


Haloperidol versus diazepam: a double-blind crossover clinical trial.


The influence of diagnostic criteria on the mortality findings in the University Group Diabetic Programme study of diabetic therapy.


Gene de-repression.

Gene de-repression.


Meteorism during treatment of respiratory-distress syndrome by intermittent positive-pressure ventilation.


Autorepressor model for control of DNA replication.


Correlation between genetic and translational maps of gene 23 in bacteriophage T4.


Invertebrate color vision and the tuned-receptor paradigm.


Enzyme electrodes.

Enzyme electrodes. From the discussion of electrodes and enzymes herein, and from the accounts of enzyme electrodes that have appeared in the literature, clinical determinations of certain metabolites and soluble enzymes by means of enzyme electrodes seem quite feasible. Such devices may be made highly specific by the use of appropriate enzymes and a high degree of accuracy can be obtained. Instantaneous and continuous determinations can be made from physiological fluids, and undesirable physiologic responses can theoretically be minimized, thus making long-term clinical monitoring a possibility. Enzyme electrodes may also have a useful lifetime and meet other practical requirements.


Chemical structures of pancreatic ribonuclease and deoxyribonuclease.


Cross-linking of collagen.

Cross-linking of collagen. The formation of collagen cross-links is attributable to the presence of two aldehyde-containing amino acids which react with other amino acids in collagen to generate difunctional, trifunctional, and tetrafunctional cross-links. A necessary prerequisite for the development of these cross-links is that the collagen molecules be assembled in the naturally occurring fibrous polymer. Once this condition is met, cross-linking occurs in a spontaneous, progressive fashion. The chemical structures of the cross-links dictate that very precise intermolecular alignments must occur in the collagen polymer. This seems to be a function of each specific collagen because the relative abundance of the different cross-links varies markedly, depending upon the tissue of origin of the collagen.


Pronase effect on pancreatic beta cell secretion and morphology. Pronase at low concentration (4 micrograms per milliliter) produces a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.


Summary of recent abstracts. IX. Helminthiasis. Trematode infections and Cestode infections.


A comparison of the effects of irradiation and immunosuppressive agents on regeneration through peripheral nerve allografts: an ultrastructural study.


Schools and classes for the deaf in the United States.


Post-secondary facilities for deaf students.


Schools and classes for the deaf in Canada.


Programs for training teachers of the deaf.


Centers for deaf-blind children.

Centers for deaf-blind children.


University programs for professional specialists.


Rehabilitation personnel serving the deaf in the United States.


Directory of programs and services for the deaf in the United States. 3. Community programs and supportive services. A. Social and recreational groups and programs.


Sympathectomy, splanchniecoctomy and vagotomy.


Directory of programs and services for the deaf in the United States. 3. Community programs and supportive services. B. Civic services.


Directory of programs and services for the deaf in the United States. 3. Community programs and supportive services. C. Clinical & evaluative programs & services.


Directory of programs and services for the daf in the United States. 4. Research and information programs and services.


Educators of the deaf.

Educators of the deaf.


A selected public health bibliography with annotations.


Saturated fat in the diet and serum cholesterol concentration: a critical examination of the literature.


Directory, American Public Health Association.


Prolonged cold ischemic times compatible with functioning renal transplants from cadavers.


Successful 24-hour preservation of canine kidneys with intracellular electrolyte solution.


Lithium carbonate in the treatment of hyperactive children.


Lithium carbonate and convulsive disorders.


The clinical pharmacology of imipramine. Implications for therapeutics.


Succinate dehydrogenase as an index of thermal injury to skin.


The effect of uraemia on organ graft survival in the rat.


The effect of malaria on the relative affinity of mouse antiprotein antibody.


Changes in acetylcholinesterase and distribution of degenerating fibres in the hippocampal region after septal lesions in the rat.


Genesis of epileptic interictal spikes. New knowledge of cortical feedback systems suggests a neurophysiological explanation of brief paroxysms.


The corpus callosum and the rabbit's visual cortex.


Non-osmotic swelling in purified bovine myelin.


Spontaneous continuous positive airway pressure (CPAP) breathing in the management of acute pulmonary edema in infants.


Extraintestinal shigellosis: bacteremia and paroxysmal atrial tachycardia. Shigella sonnei in a three-year-old boy.


Kinetics of the mechanism of action of flavin pyruvate oxidase from an acetate requiring mutant of Escherichia coli.


Effects of acrolein on DNA synthesis in vitro.


Formylation of mischarged E. coli tRNA Met  f .


31 P NMR studies on phosphate binding to the Zn 2+ , Co 2+  and Mn 2+  forms of escherichia coli alkaline phosphatase.


Wroclaw phoniatrics in the past twenty years.


The role of messenger RNA and peptidyl-tRNA in the synthesis of the guanine nucleotides MS I and MS II by ribosomes in vivo.


Temperature-dependent inactivation of tRNA Tyr  E.coli  acceptor function with iodine: influence of the 3'-terminal pCpA sequence.


Colonic absorption in idiopathic constipation.


Congenital hepatic fibrosis--is it a single clinical entity?


Tropical enteropathy.

Tropical enteropathy.


Positive tissue antibody tests in patients with prolonged extrahepatic biliary obstruction.


Post-stapedectomy granuloma of the oval window.


Are you classified properly in the American Dental Directory?


Sixteen referenda on fluoridation in Massachusetts; an analysis.


The treatment of subfertile men with clomiphene citrate.


Postoperative problems of tracheal resection.


Directory of otolaryngologic societies.

Directory of otolaryngologic societies.


Lung defense mechanisms.

Lung defense mechanisms.


Environmental lung disease.

Environmental lung disease.


Chronic bronchitis and emphysema. Classification and epidemiology.


Chronic bronchitis and emphysema.

Chronic bronchitis and emphysema.


The pathophysiology of chronic bronchitis and emphysema.


Early detection of obstructive lung diseases.


Chronic bronchitis and emphysema. Clinical diagnosis and evaluation.


The roentgenologic manifestations of emphysema and chronic bronchitis.


Infection: the real culprit in chronic bronchitis and emphysema?


Evaluation of disability and assessment of operative risk.


Methods of ambulatory care.

Methods of ambulatory care.


The development of the nervous system in the heart of the Chinese carp, Cyprinus carpio (Linnaeus), with a special reference to its conducting system.


The management of acute ventilatory failure in chronic obstructive lung disease.


Depression of immune response to Moloney leukaemia virus by malarial infection.


Radioimmunoassay of luteinizing hormone releasing hormone.


Protection against enteric disease caused by Escherichia coli--a model for vaccination with a virulence determinant?


Bidirectional growth of the E. coli chromosome.


Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells.


IgD on the surface of peripheral blood lymphocytes of the human newborn.


The immune system as a model for cellular maturation and differentiation.


Sheila Frances Hurrell.

Sheila Frances Hurrell.


Some highlights in the history of nitrous oxide.


American Pediatric Society Membership List 1972-1973.


Society for Pediatric Research Membership List 1973-1974.


The stereochemistry of actinomycin binding to DNA and its implications in molecular biology.


Reactions of nucleic acids and nucleoproteins with formaldehyde.


Recognition in nucleic acids and the anticodon families.


Synthesis and functions of the -C-C-A terminus of transfer RNA.


Translation and transcription of the tryptophan operon.


Mammalian RNA polymerases.

Mammalian RNA polymerases.


Summary of recent abstracts. I. Cholera.


Penfluridol (R 16341). A long-acting oral neuroleptic, as maintenance therapy for schizophrenic and mentally retarded patients. A placebo-controlled double-blind trial.


Immunology of experimental infections with Schistosoma mansoni in the swiss mouse and with Fasciola hepatica in the rabbit.


Managing pulmonary edema.

Managing pulmonary edema.


Timely topics in general microbiology, 1970-1971.


Giardiasis--a cause of vitamin B 12  malabsorption.


Paired donor eyes in penetrating keratoplasty.


A scleral expander for prevention of scleral collapse during intraocular surgery.


Preparing vertical histological sections of the rat aorta rolled up in a sheath of macaroni.


A reappraisal of the nature and significance of chronic atrophic gastritis.


Electron microscopic studies of swollen corneal stroma.


Insulo-acinar portal system in the horse pancreas.


Ultraviolet effects on biological function of RNA phage MS2.


DNA labelling and its assay in yeast.

DNA labelling and its assay in yeast.


Correlation between degradation, replication and repair of yeast DNA irradiated by ultraviolet or  -rays.


Properties of an ATP-dependent deoxyribonuclease from Micrococcus luteus. Evidence for a stable DNA-enzyme complex.


Resistance transfer between E. coli and Salmonella strains from Kerala.


Spot test for DDS (diamino diphenyl sulphone) in urine under field conditions.


Comparative evaluation of latex agglutination test in serodiagnosis of amoebiasis.


An experimental study of trypan blue induced antenatal hydrocephalus and other neurological abnormalities in rats.


Restoration of fractured anterior teeth with ultraviolet-light-polymerized bonding materials: a new technique.


The scientifically designed partial veneer crown.


A review of approaches to the detection of dental caries. Council on Dental Materials and Devices.


Mouth protectors: 11 years later. Bureau of Dental Health Education, Council on Dental Materials and Devices.


Multiple antimicrobial resistance in Escherichia coli isolated from the urine of dogs and cats with cystitis.


Radioimmunoassay of luteinizing hormone releasing factor.


Variations in pituitary responsiveness to luteinizing hormone releasing factor during the rat oestrous cycle.


Blood flow changes in the pituitary neural lobe of the rabbit associated with neurohypophysial hormone-releasing stimuli.


Intermediate and reconstructive care of maxillofacial missile wounds.


Maxillofacial missile wounds: evaluation of long-term results of rehabilitation and reconstruction.


Mandibular reconstruction.

Mandibular reconstruction.


Salmonellosis in passerine birds in Maryland and West Virginia.


Mediastinal emphysema after oral surgery.


Specific biosynthesis of an envelope protein of Escherichia coli.


Academician K. I. Skryabin.

Academician K. I. Skryabin.


Hormonal pregnancy tests and spina bifida.


Theophylline-induced translocation of calcium in the pancreatic beta cell: inhibition by deuterium oxide.


Antigen-sensitized cells of lymphoid organs lysed in vitro by specific antigens.


Prognosis of injured canaliculi in relation to elapsed time until primary operation.


Developmental aspects of the human lung.


Difficulties in distinguishing cardiac from pulmonary disease in the neonate.


Practical pulmonary physiology. A functional analysis of symptoms and therapeutic measures in respiratory disorders of newborn infants.


The roentgenographic course and complications of hyaline membrane disease.


Continuous negative chest wall pressure therapy for hyaline membrane disease.


Fetal lung development. Current concepts.


Some important aspects of neonatal nursing related to pulmonary disease and family involvement.


The use and misuse of oxygen in the newborn infant.


History and demography of child abuse.

History and demography of child abuse.


Phenylketonuria and other disorders of amino acid metabolism.


Delayed primary excision and skin grafting of the burned hand.


Primary vaginal reconstruction after pelvic exenteration.


Surgical management of the bilateral cleft lip.


Viability of split-skin grafts from pigs following incubation on autologous blood or serum for various periods.


The skin graft donor site as a model for evaluation of hemostatic agents.


Ear reattachment by the modified pocket principle. Case report.


Gerald Brown O'Connor, M.D. 1900-1972.

Gerald Brown O'Connor, M.D. 1900-1972.


Hemoglobin iron kinetics in man.

Hemoglobin iron kinetics in man.


Members of the R.N.A.

Members of the R.N.A.


In memoriam. Daniel de Bruijn.

In memoriam. Daniel de Bruijn.


Paul W. Clough 1882-1970.

Paul W. Clough 1882-1970.


Carlton Ernstene 1901-1971.

Carlton Ernstene 1901-1971.


Franklin M. Hanger 1894-1971.

Franklin M. Hanger 1894-1971.


Hans Hecht 1913-1971.

Hans Hecht 1913-1971.


Robert W. Heinle 1909-1972.

Robert W. Heinle 1909-1972.


The way of the future.

The way of the future.


Pathogenesis and immunology of trachoma.


Bernardo A. Houssay 1887-1971.

Bernardo A. Houssay 1887-1971.


Chester Scott Keefer 1897-1972.

Chester Scott Keefer 1897-1972.


Edwin Allen Locke 1874-1971.

Edwin Allen Locke 1874-1971.


Colin Munro MacLeod 1909-1972.

Colin Munro MacLeod 1909-1972.


William Sharp McCann 1889-1971.

William Sharp McCann 1889-1971.


F. Maurice McPhedran 1888-1970.

F. Maurice McPhedran 1888-1970.


John Rodman Paul 1893-1971.

John Rodman Paul 1893-1971.


Joseph Stokes, Jr. 1896-1972.

Joseph Stokes, Jr. 1896-1972.


Harry B. Van Dyke 1895-1971.

Harry B. Van Dyke 1895-1971.


Roy Hope Turner 1894-1971.

Roy Hope Turner 1894-1971.


Donald Dexter Van Slyke 1883-1971.

Donald Dexter Van Slyke 1883-1971.


Presentation of the Kober Medal for 1972 to C.J. Watson.


Acceptance of the Kober Medal for 1972.

Acceptance of the Kober Medal for 1972.


Association of American Physicians. Francis Gilman Blake Award.


Howard Lang Alt 1900-1972.

Howard Lang Alt 1900-1972.


Officers and members of the Association of American Physicians.


Solomon A. Berson 1918-1972.

Solomon A. Berson 1918-1972.


Summary of recent abstracts. 3. Malaria.2.


Deacylation of benzylpenicillin and of some of its modified structures with penicillin acylase of Escherichia coli.


Renal autotransplantation: report of three cases.


The inhibitory action of garlic (Allium sativum L.) on growth and respiration of some microorganisms.


Quality control recording methods in microbiology.


Evaluation of a new preservative for urine cultures.


Correlation of coagulase and mannitol test in human and animal staphylococci.


Recommendations for the improvement of clinical mycology laboratories.


Carbenicillin indanyl sodium oral therapy of urinary tract infections.


Renal failure and transient paraproteinemia due to Leptospira pomona. Case reports and literature review.


Aberrant synaptic development.

Aberrant synaptic development.


Septicemia in renal transplant recipients.


Biological dressings for skin graft donor sites.


Effect of pancreatic enzymes on protruding ileostomy stomas.


Simplified method of needle-holder handling.


Peritoneal dialysis in children. A survey of its indications and applications.


Clinical evaluation of the anorexic activity and safety of 42-548 in children. Report of a clinical trial.


The stimulus-secretion coupling of glucose-induced insulin release. XII. Effects of diazoxide and gliclazide upon  45 calcium efflux from perifused islets.


Effects of chronic treatment with LH-FSH-RH in hypophysectomized pituitary-grafted male rats.


The primary structure of an acidic protein from 50-S ribosomes of Escherichia coli which is involved in GTP hydrolysis dependent on elongation factors G and T.


Role of DNA-RNA hybrids in eukaryotes. Purification and properties of yeast RNA polymerase B.


Affinity elution as a purification method for aminoacyl-tRNA synthetases.


Evidence for metabolic compartmentation in Escherichia coli.


Maintenance of leptospira by storage at -75 C.


A historadiographic method for identifying osteoid seams in bone using silver impregnation.


Costs predicate planning.

Costs predicate planning.


Grades as predictors of physicians' career performance: an evaluative literature review.


Increased inactivation of messengers in Escherichia coli ts mutant.


Separation of populations of human lymphocytes by freezing and thawing.


Properties of reconstituted chromatin and nucleohistone complexes.


Angular alteration of the DNA helix by E. coli RNA polymerase.


Lack of discrimination between early and late T4 mRNA by host initiation factors.


Synthesis of carcinoembryonic antigen in vitro.


Tubular reabsorption of bicarbonate in transplanted cadaver kidneys.


Acute renal failure during intermittent rifampicin therapy.


Neurosurgical belief of chronic pain.

Neurosurgical belief of chronic pain.


Effect of synthetic gonadotrophin-releasing hormone (Gn-RH) on ovulation blockade by aspirin and indomethacin.


The antibacterial activity of semen and its relation to semen proteins.


The dialysis branch of a transplantation unit.


Gamma-camera scintigraphy after kidney transplantation.


Urinary tract infection with disappearance of urinary creatinine. Case report.


Organ culture of benign nodular hyperplasia of human prostate in chemically-defined medium.


Principles of cardiopulmonary medicine.

Principles of cardiopulmonary medicine.


Avian anesthesia.

Avian anesthesia.


Refractory laminitis.

Refractory laminitis.


Equine hepatic insufficiency.

Equine hepatic insufficiency.


The acute colitis syndrome. Colitis "X".


A study on the postnatal histology of the testis in buffalo (Bubalus bubalis). I. From birth to one year.


Application of stereotaxic methods in neuroradiologic diagnosis.


Disturbances in the regulation of food intake. Obesity: anatomic and physiologic-biochemical observations.


The treatment of obesity.

The treatment of obesity.


Complications of portacaval anastomosis. By-products of a controlled investigation.


On cardiac murmurs by Austin Flint, the American Journal of the Medical Sciences in 1862 (volume 44).


The liver in congestive heart failure: a review.


Posterior fusion in cervical spine injuries. An analysis of fifty cases treated surgically.


Systemic thrombosing vasculitis, malignant atrophic papulosis of Degos. Review of the literature.


Giants in those days.

Giants in those days.


Cardiopulmonary blood compartments in chronic pressure overload of the left ventricle.


Subdiaphragmatic vena caval flow patterns in dogs ventilated with pressure-controlled respirator Bennett PR-2.


Subdiaphragmatic vena caval flow patterns in dogs ventilated with variously adjusted Engström respirator.


Mutagenicity trials under toxicological aspects.


Overfeeding and obesity in infants and children.


Changing concepts of prolactin in man.

Changing concepts of prolactin in man.


Malaria.

Malaria. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. David W. Martin, Jr., Assistant Professor of Medicine, and Kenneth A. Woeber, Associate Professor of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine. Requests for reprints should be sent to the Department of Medicine, University of California, San Francisco, San Francisco, Ca. 94122.


Acupuncture in traditional Chinese medicine. An historical review.


Cellular-versus-humoral autoimmune responses to salivary gland in Sjögren's syndrome.


Effect of lymphocyte mediators on macrophages in vitro. A correlation of morphological and cytochemical changes.


The immunological significance of histological changes in the spleen and liver in mouse malaria.


ATP and cell integrity.

ATP and cell integrity.


Annual administrative reviews: safety.

Annual administrative reviews: safety.


Amazing historical and biological errors in abortion decision.


Annual administrative reviews: ambulatory services.


Annual administrative reviews: continuity of care.


Annual administrative reviews: education.


Annual administrative reviews: food service.


Annual administrative reviews: pharmacy.


Annual administrative reviews: auxiliaries and volunteer services.


Annual administrative reviews: community relations.


Annual administrative reviews: consumer views.


Annual administrative reviews: mergers and shared services.


Annual administrative reviews: governance.


Annual administrative reviews: financial mechanisms.


Annual administrative reviews: personnel management.


Annual administrative reviews: environmental health concerns.


Annual administrative reviews: hospital engineering.


The Treponema pallidum haemagglutination (TPHA) test in biological false positive and leprosy sera. The Treponema pallidum haemagglutination (TPHA) test was carried out on 274 sera known to show biological false positive reactions to reagin tests for syphilis. The Treponema pallidum immunization (TPI) and fluorescent treponemal antibody absorption (FTA-ABS) tests were non-reactive on all these sera. Thirty-one or 11.3% showed reactive results in the TPHA test. Sera from 267 people who had lepromatous leprosy were also tested in the TPHA test. Fourteen sera were reactive in the TPHA, TPI, and FTA-ABS tests and were from people who had both syphilis and leprosy. Biological false positive reactions were shown by 26 of the leprosy sera, of which three or 11.5% were also reactive in the TPHA test. A further four sera in the leprosy group were reactive only in the TPHA test. The possible cause of false reactive TPHA test results is discussed. It was concluded that where reagin and TPHA tests are reactive in a person who has no history or clinical signs of syphilis, the serum should be referred for TPI and FTA-ABS testing.


Indirect cutaneous immunofluorescence. II. Clinical significance. Sera of 532 patients with bullous diseases, connective tissue diseases and malignancies were tested for pemphigus epidermal intercellular fluorescence (ICF) and for the bullous pemphigoid ;tubular' band by the indirect fluorescent antibody technique. Human normal skin cryostat sections were used. The band and ICF were seen primarily only in bullous pemphigoid and pemphigus respectively, Some indirect band and ICF-negative patients demonstrated positive direct results in involved skin. suggesting that direct tests should be performed in indirect negative patients clinically thought to have pemphigus or bullous pemphigoid. No close correlation was found between disease activity and positive or negative indirect tests in bullous pemphigoid and pemphigus. Steroids did not interfere with positive results of this diagnostically extremely valuable test.


Monitoring of congenital defects.

Monitoring of congenital defects.


A comparison of rapid methods including imprint cytodiagnosis for the diagnosis of breast tumours. Rapid diagnoses were made on 510 breast lumps by three methods in sequence and the results compared with those obtained by paraffin histology.Naked-eye examination of the excised lumps correctly distinguished between benign and malignant tumours in 95.1% of cases with 23 (4.5%) false negative and two (0.4%) false positive results.Rapid imprint cytodiagnosis was correct in 96.9% of the 391 lumps imprinted with 12 (3.1%) false negatives and no false positive results. Frozen sections gave the correct diagnosis in 99.4% of the 510 cases with three (0.6%) false negative and no false positive results. The use of cytology in the diagnosis of breast tumours is discussed.


Problems of financing prepaid group practice in the university.


Distinguished Nuclear Pioneer--1973. Lise Meitner.


Distinguished Nuclear Pioneer Lecturer--1973. Otto Frisch.


Penetrating wounds of the neck: surgical management.


Recent advances in bacteriological aspects of gastroenteritis.


Total avulsion of the scalp.

Total avulsion of the scalp.


Papilloma induction in different aged skin grafts to young recipients.


Genesis of neuronal patterns.

Genesis of neuronal patterns.


Hector Berlioz, 1803-1869.

Hector Berlioz, 1803-1869.


Infectious complications of acute pancreatitis.


A critique of the first treatment of carcinoma of the breast.


Ventilatory management in acute pulmonary edema.


Cardiac transplantation in man. Review of first three years' experience.


Karl Murdock Bowman. 1888-1973.

Karl Murdock Bowman. 1888-1973.


Mesoridazine versus chlorpromazine in acute schizophrenia: a double-blind investigation.


Lawrence Kolb. 1881-1972.

Lawrence Kolb. 1881-1972.


Cancer immunotherapy. A new explanation for some old observations.


Polymer-bound dihydrolipoic acid: a new insoluble reducing agent for disulfides.


Sequence of amino acids in the   chain of single hemoglobins from C57BL, SWR, and NB mice.


Caloric catastrophe.

Caloric catastrophe. Six solutes known to be actively transported by bacteria were studied with the cell in a "minimum energy" state to determine if sufficient energy were available from cellular stores of ATP to supply the energy necessary to run postulated membrane-situated "pumps." Steady-state cellular concentrations of potassium, calcium, magnesium, leucine, glycine, and alpha-methyl glucoside were determined together with tracer fluxes, oxygen consumption, ATP turnover, and the P:O ratio. From these measurements, it was calculated that the energy supply, 4.20 cal/340 min-g dry wt, fell far short of the energy necessary (28.28 cal/340 min-g dry wt), by classical membrane theory, to operate "pumps."


Pitfalls in digital computation of the impulse response of vascular beds from indicator-dilution curves.


Effect of acute isovolemic anemia on cardiac output and estimated hepatic blood flow in the conscious dog.


On some aspects of cellular interaction between immunocompetent and haemopoietic cells.


Hospital-physician relationships: deferred compensation as a tax planning technique.


Cytological and cytochemical studies of Reovirus type 3 infected bonnet monkey kidney cell culture.


Acquired B character caused by E. coli 0124 bacterial infection: a case report.


Effect of phytohaemagglutinin on growth of Escherichia coli.


Distribution of immunoglobulins in palatine and pharyngeal tonsils.


Antibody-inhibiting activity of bone marrow cells in vitro.


Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.


Turnover of ribosomal RNA during the stringent response in Escherichia coli.


5 s RNA conformation. Studies of its partial T 1 ribonuclease digestion by gel electrophoresis and two-dimensional thin-layer chromatography.


Synthesis of endogenous pyrogen by rabbit leukocytes. Rabbit ieukocytes from peritoneal exudates and from blood were stimulated to form leukocyte pyrogen in the presence of radiolabeled amino acids. The stimuli used were endotoxin, phagocytosis, and tuberculin. The crude leukocyte pyrogen samples were purified; pyrogen from exudate cells was rendered homogeneous; pyrogen from blood cells was still contaminated with other proteins. All the purified pyrogens were radioactive; and for all it was shown that radioactivity and pyrogenic activity coincided on electrophoresis at pH 3.5 and pH 9 in acrylamide and on isoelectric focusing in acrylamide. Furthermore, pyrogens obtained from exudate cells stimulated in different ways, or from blood cells and exudate cells stimulated with endotoxin, appeared to be identical. These results suggest that leukocyte pyrogen was synthesized de novo from amino acid precursors and that leukocytes made the same pyrogen whatever the stimulus used to activate them.


Large repetition in the non-permuted nucleotide sequence of bacteriophage TI DNA.


Lac repressor binding to non-operator DNA: detailed studies and a comparison of eequilibrium and rate competition methods.


The extent of base pairing in 5 s RNA. Yeast 5 s RNA.


Investigation of exchangeable protons and the extent of base pairings in yeast phenylalanine transfer RNA by high resolution nuclear magnetic resonance.


Regulation of ribonucleic acid synthesis in growing bacterial cells. I. Control over the total rate of RNA synthesis.


Regulation of ribonucleic acid synthesis in growing bacterial cells. II. Control over the composition of the newly made RNA.


Electron microscopy of Escherichia coli ribosomal RNA: spreading without a basic protein film.


Progressive loss of H-2 antigens with concomitant increase of cell-surface antigen(s) determined by Moloney leukemia virus in cultured murine lymphomas.


Use of disomics in mapping ribosomal RNA genes in Saccharomyces cerevisiae.


Function of bone marrow in suppressing thymic lymphomas induced by 7,12-dimethylbenz(a)anthracene.


Hildrus Augustus Poindexter, M.D., M.P.H., Ph.D., D.Sc., 1901-.


Platelet survival in rabbits to detect hyperacute rejection.


Induction of tolerance in rats by treatment with antithymocyte serum and adult skin homografts.


The growth and development of allotransplanted neonatal canine kidneys.


Factors influencing the measurement of pulmonary extravascular water.


Alimentary tract colonization by Candida albicans.


Dr John Alfred Carr: a psychohistorical study.


The scanning electron microscope and its applications to research (continuation).


Restoration by the rac locus of recombinant forming ability in recB -  and recC -  merozygotes of Escherichia coli K-12.


Mitotic intragenic recombination as a consequence of heteroduplex formation in Aspergillus nidulans.


Lysogenization by bacteriophage lambda. I. Multiple infection and the lysogenic response.


Yeast mutants resistant to ethidium bromide.


Frameshift suppression: a nucleotide addition in the anticodon of a glycine transfer RNA.


Immunosuppression versus immunity in syngeneic and allogeneic tumours.


Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. II. Reticulosarcoma. (Correlation with the immunity reaction of the cellular type and the clinical status).


Daunorubicin and adriamycin in the treatment of leukemia.


An appraisal of the uricult dip-slide method in the diagnosis of urinary infections.


C. G. S. van Heyningen.

C. G. S. van Heyningen.


Absence of cognitive deficits from bilateral cingulotomy for intractable pain in humans.


The pediatrics of Benjamin Rush.

The pediatrics of Benjamin Rush.


Memoir of Samuel William Eisenberg 1907-1972.


Memoir of Emily Bacon 1891-1972.

Memoir of Emily Bacon 1891-1972.


Memoir of Richard Harrison Shryock 1893-1972.


Homage to Louis Pasteur (1822-95).

Homage to Louis Pasteur (1822-95).


Memoir of William Joseph Somerville 1915-70.


Memoir of Harry Sands Weaver, Jr. 1903-72.


Thermal dilution for measurement of cardiac output in the pulmonary artery in man in relation to choice of indicator volume and injection time.


Endocrinopathies and uric acid metabolis.


In Memoriam. Edward Henderson, M.D., 1896-1973.


Studies on the improvement of treatment of Habu (Trimeresurus flavoviridis) bites. 9. Studies on the immunogenicity of the purified Habu venom toxoid by alcohol precipitation.


The distribution of vasopressin and neurophysin in the hypothalamo-distal-neurohypophysial and hypothalamo-infundibular neurosecretory systems of normal and scrapie-affected sheep.


Inhibition of glucose-induced electrical activity in pancreatic islet cells by phloridzin, mannoheptulose, and anoxia.


The influence of diffusion on indicator-dilution measurements of blood flow.


Some early European observations on acupuncture.


Head and neck cancer in alcoholics. The relationship to drinking, smoking, and dietary patterns.


Transplantation, immunosuppression, and oncogenesis.


In memoriam.

In memoriam.


Directory of otolaryngologic societies.

Directory of otolaryngologic societies.


Surgery for atrio-ventricular (endocardial cushion) defects with particular reference to the mitral valve.


Obituary. Kenneth Guthrie Salmond.

Obituary. Kenneth Guthrie Salmond.


Instrumental methods in biosynthetic studies.


Interference between the uptake of pyrimidines and purines in yeasts.


Metabolism of hormones, drugs and other substances by the gut.


Identification by HL-A markers of human cells used for vaccines (complementary research).


General discussion on the papers of session I. Developments with hepatitis.


Continuous and semi-continuous cultivation of Vibrio cholerae.


Suggested adoption of a non-motile variant of strain Ty 2 for vaccination against typhoid fever.


Neutralization of bactericidal antibodies and immunogenicity in mice of S. typhi cell fractions.


Further studies of protective activity of antigen complexes of typhoid and paratyphoid B vaccines.


The significance of protection tests in mice for evaluating typhoid vaccines.


Detection in serum hepatitis of the Au-anti-Au immune complex and of the antigen and antibody by means of the modified electrosyneresis technique.


Detection and delineation of abdominal abscesss in rabbits with  67 Ga.


J. Robert Cornwell, M.D. 1922-1972.

J. Robert Cornwell, M.D. 1922-1972.


William Arthur Matthews, M.D. 1911-1972.


Some characteristics and control of pantothenate transport in Escherichia coli U-5-41.


Repair of the oral cavity after irradiation and resection for oral carcinoma.


The potential toxicity of excessive polyunsaturates. Do not let the patient harm himself.


Quantification of pulmonary blood flow by a radioisotope technique: validation in normal dogs, and in dogs with aortopulmonary shunts.


Toxicity of ethacrynic acid and furosemide.


Interference contrast microscopy in the laboratory.


A biomechanical and physiological approach to corrective surgery for senile entropion.


Free-floating cysts of the ocular media.


Identifying prosthesis components.

Identifying prosthesis components.


Membrane structure and electron microscopy. The significance of physical problems and techniques (freeze etching).


The effects of chronic increased lead absorption on the nervous system--a review article.


Trends in biophysical research and their implications for medical libraries. This is a statistical survey of the trends in biophysical research as reflected by papers presented at four Biophysical Society (BPS) annual meetings between 1958 and 1972 and by the funding sources of the reported projects. The study reveals that biophysical research has grown quite substantially, particularly since 1968. Although biophysics is truly interdisciplinary, since 1968 there has been more pronounced emphasis on biomedically oriented problems and a tendency toward more specific and more highly specialized problems. Between 1958 and 1972, most biophysicists were academic researchers, 50% of whom were biomedical scientists. Over three quarters of the ongoing biophysical research projects during this period were supported by governmental agencies, and among them, the National Institutes of Health was the largest single funding source.


Harold A. Izant.

Harold A. Izant.


Intravenous diazepam: an improvement in pre-endoscopic medication.


Fractionation of native and denatured deoxyribonucleic acid on agarose columns.


The tryptophanase from Escherichia coli K-12. II. Comparison of the thermal stabilities of apo-, holo-, and hybrid enzymes.


L-Asparaginase from Erwinia carotovora. Physicochemical properties of the native and succinylated enzyme.


Studies on the conversion of proinsulin to insulin. II. Evidence for a chymotrypsin-like cleavage in the connecting peptide region of insulin precursors in the rat.


Anatomic connections of the fastigial nucleus to the rostral forebrain in the cat.


Reversible ischemic colitis.

Reversible ischemic colitis.


An electrophysiological study. The origin of the crossed olivocochlear bundle.


Threonine deaminase from Escherichia coli. I. Purification and properties.


Mechanisms of active transport in isolated bacterial membrane vesicles. 8. Valinomycin-induced rubidium transport.


Ribonuclease II of Escherichia coli is not inhibited by adenosine triphosphate.


Phosphorylation of ceramide by diglyceride kinase preparations from Escherichia coli.


Rudolf Dreikurs Biblography : 1967-1972.


Distribution of cerebellar-induced responses in the cerebral cortex.


In memory of Rudolf Dreikurs, 1897-1972. Special session of the American Society of Adlerian Psychology, Houston, Texas, May 28, 1972.


Nasopharyngeal ventilation in respiratory distress syndrome. A simple and efficient method of delivering continuous positive airway pressure.


John Stuart Mill's "Mental Crisis": Adlerian interpreation.


Controlled trial of continuous negative external pressure in the treatment of severe respiratory distress syndrome.


The effect of hexachlorophene on staphylococcal colonization rates in the newborn infant: a controlled study using a single-bath method.


Studies on the nuclear and nucleolar ultrastructure in differentiating and differentiated human sebaceous cells.


Host resistance factors in human milk.

Host resistance factors in human milk. This paper discusses the nature of host resistance factors in human milk and epidemiologic studies regarding infections and mortality rates in breastfed and nonbreastfed babies.  The defense factors and their proposed modes of action are:  1) a growth enhancer of lactobacilli, which interferes with intestinal colonization of enteric pathogens; 2) antistaphylococcal factors, which inhibit staphylococci; 3) secretory IgA and other immunoglobulins, which protect the gut and respiratory tract; 4) C4 and C3 (complement components; C3 fragments have opsonic, chemotactic, and anaphylatoxic activities); 5) lysozome, lysis of bacterial cell wall; 6) lactoperoxidase, killing of streptococci; 7) lactoferrin, kills microorganism by chelating iron, and 8) macrophages and lymphocytes, phagocytosis and cell-mediated immunity.  Although it can be postulated that the breastfed infant's resistance to infection would be superior on account of the greater presence of these factors in human milk compared to cow's milk, little is known about the effects of these defense factors on the infant.  Epidemiologic studies have reported on the lower morbidity and mortality rates of breastfed infants as compared to bottlefed infants.  Other studies have focused on the protective effects of human milk upon the infant, but these have been inconclusive.  In countries with poor sanitation and high infection rates, the incidence of bacterial infections is lowest in breastfed infants.  The advantages of human milk however are difficult to demonstrate in societies with high standards of sanitation and low infection rates.  Infection and mortality rates in infants have in fact declined in developed countries as the practice of breastfeeding declined.  Until it is established that immunity to common pathogens is transmitted to the infant by human milk, it will not be known whether human milk does have protective effects.


The electron microscopic localization of cations to pancreatic islets of Langerhans and their possible tole in insulin secretion.


Beginning endochondral ossification in embryonic mouse radii.


Pulmonary alveolar proteinosis. Home treatment with intermittent positive pressure breathing.


Cancer and immune mechanisms.

Cancer and immune mechanisms.


The histologic distribution of the blood group substances in man as disclosed by immunofluorescence. VI. The Le    and Le    antigens during fetal development.


Fine structure of early experimental acute pancreatitis in dogs.


Species distribution and properties of nuclear satellite DNA in higher plants.


Radiobiological data on time-dose relationships.


Some late effects of radiation in the bone marrow stem cells of the mouse.


Cancer of the floor of the mouth and the gingiva.


Orthognathic surgery.

Orthognathic surgery.


Basic plastic surgical techniques in repair of facial lacerations.


Trauma to the neck region.

Trauma to the neck region.


The management of common facial fractures.


Burns of the head and neck.

Burns of the head and neck.


Intraoral prosthetic rehabilitation in patients with an extensive facial reconstruction.


Hypertriglyceridemia in chronic nonnephrotic renal failure.


Effect of human chorionic gonadotrophin on weight loss, hunger, and feeling of well-being.


Bacterial diarrheas.

Bacterial diarrheas.


Dietary plant sterols: current status in human and animal sterol metabolism.


Massive diastematomyelia without cutaneous dysraphism.


Duodenal mucosal damage in 31 infants with gastroenteritis.


The Medical Society of London.

The Medical Society of London.


Report of the Advisory Committee on Asbestos Cancers to the Director of the International Agency for Research on Cancer.


Treatment of acute lymphoblastic leukaemia: effect of "prophylactic" therapy against central nervous system leukaemia. Report ot the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood. A total of 177 patients with acute lymphoblastic leukaemia aged 1 to 13 years were entered in a trial in which one of the variables was "prophylactic" treatment against central nervous system (C.N.S.) relapse. Patients who achieved haematological remission on a standard chemotherapy regimen either received or did not receive craniospinal irradiation plus intrathecal methotrexate.Of the 80 patients who did not receive prophylactic C.N.S. treatment remission was terminated by meningeal leukaemia in 26. The corresponding figure for patients given prophylactic C.N.S. treatment was only 1 out of 75. The incidence of marrow relapse, however, is so far similar in the two groups.If the occurrence of either meningeal leukaemia or marrow relapse is taken to indicate recurrence of leukaemia then 32 out of 80 patients receiving no C.N.S. prophylaxis have so far relapsed compared with 14 out of 75 patients who received C.N.S. prophylaxis. This represents a halving of the recurrence rate in the prophylactic group: it is estimated that 75% of this group will remain free of either form of recurrence for 71 weeks after radiation treatment.


Clinical assessment of a low-oestrogen combined oral contraceptive. A 21-tablet oral contraceptive packet containing .5 mg dl-norgestrel and .03 mg estradiol was clinically tested in 1085 women of reproductive age for a total of 7323 cycles.  There was 1 pregnancy which may have been due to incorrect tablet use.  98.2% of the cycles fell within a 28-day plus or minus 3-day pattern.  21% of the women had some breakthrough bleeding at some time, but it was confined to 1 cycle in 63% and not more than 2 cycles in 82%.  The contraceptive is recommended for general use on the bases of how pregnancy rate, mean intermenstrual bleeding of .54 days per cycle, and the mean total bleeding of 4.87 days per cycle.  The hypothesis that an effective combined oral contraceptive using norgestrel as the progestogen can employ as little as 30 mcg of estrogen is supported.


Immunosuppressive consequences of radiotherapy and chemotherapy in patients with acute lymphoblastic leukaemia. Assays of lymphocyte subpopulations and function have been performed on patients with acute lymphoblastic leukaemia still in remission after 18 months' treatment. The patients were subjects of a trial of the value of craniospinal irradiation in the third month of treatment in preventing central nervous system relapse. Effects of both irradiation and chemotherapy were observed. Lymphopenia was much more marked in those patients who had received irradiation over a year previously. Assays of response to phytohaemagglutinin (P.H.A.) and staining for surface immunoglobulin indicated that this difference was due to a deficiency in thymus-dependent lymphocytes in the irradiated children. Chemotherapy had a particularly marked depressant effect on lymphocytes with antibody-dependent cytotoxic activity and a proportion of PHA-responsive cells were also depressed. It may be relevant that four of the patients depleted of thymus-dependent lymphocytes by radiation died of infection during remission, while none of those treated with chemotherapy alone died in remission.


David Livingstone.

David Livingstone.


Livingston's example.

Livingston's example.


Infantile Hodgkin's disease: remission after measles.


Bacterial resistance in the community.

Bacterial resistance in the community.


I. Blain.

I. Blain.


R.B. Green.

R.B. Green.


R.A. Zeitlin.

R.A. Zeitlin.


I.G. Wickes.

I.G. Wickes.


R.D. Clay.

R.D. Clay.


Daunorubicin (NSC-83142) versus daunorubicin plus prednisone (NSC-10023) versus daunorubicin plus vincristine (NSC-67574) plus prednisone in advanced childhood acute lymphocytic leukemia.


Phase II evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in patients with solid tumors.


BCNU (NSC-409962) in the treatment of bronchogenic carcinoma.


Enhancement of asparaginase-induced regression of the 6C3HED lymphosarcoma by protein-free diet.


Physical binding of labeled 20-methylcholanthrene to mouse epidermal subcellular fractions.


The incorporation of 6-thioguanine into RNA fractions and its effect on RNA and protein biosynthesis in mouse sarcoma 180 ascites cells.


The application of electron microscopy to the diagnostic differentiation of Ewing's sarcoma and reticulum cell sarcoma of bone.


The Kocher-McFarland approach to the hip joint for prosthetic replacements.


An experimental study of the immediate load bearing capacity of three surgical constructions for anterior spine fusions.


The classic. Cleavage of the cutis (the anatomy and physiology of the skin). Karl Langer, in: Sitzungberiche Akadamie der Wissenshaften Math. Natur W. CL, Vol. 43, Part 1, June, 1861.


Low-friction arthroplasty in congenital subluxation of the hip.


In memoriam Edward Wilson, M.D.

In memoriam Edward Wilson, M.D.


The paraspinal sacrospinalis-splitting approach to the lumbar spine.


An approach for hip construction: broad visualization without osteotomy of the greater trochanter.


Essential fatty acid requirements of cells in tissue culture: a review.


William J, Schnute, M.D., 1914-1972.

William J, Schnute, M.D., 1914-1972.


DNA strand breaks from tritium decay: a local effect for cytosine-6- 3 H.


Emergency hemorrhoidectomy--a worthwhile procedure.


Who is Houstoun? A biography of Robert Houstoun M.D., F.R.S. 1678-1734.


Incidence and distribution of yeast species and of Trichomonas vaginalis in the vagina of pregnant women.


The fatal potential of fistula-in-ano with abscess: analysis of 11 deaths.


Criteria for diagnosis of candida vulvovaginitis in pregnant women.


Nathan Smith Davis. An autobiographical letter, previously unpublished.


Respiratory maneuvers to prevent postoperative pulmonary complications. A critical review.


Biologic false-positive FTA-ABS test in drug-induced lupus erythematosus.


Group A  -hemolytic streptococcemia. Bacteriologic and clinical study of 44 cases.


Historical vignette. Account of a world of difficulties.


Limitations of the usefulness of the Limulus assay for endotoxin.


Surgical management of neonatal jaundice.


Multiple pregnancy. 1.

Multiple pregnancy. 1.


Impact of HR-1 on the therapy of end-stage uremia. How and where should uremia be treated.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1973.


Evaluation of renal-failure treatment.

Evaluation of renal-failure treatment.


Mutant tyrosine transfer RNA that can be charged with glutamine.


Formation of the recB-recC DNase by in vitro complementation and evidence concerning its subunit nature.


A nurse and her hospital: a profile of Joyce Rodmell.


Miss Nightingale's country hospital.

Miss Nightingale's country hospital.


The impact of the Rochester Neighborhood Health Center on hospitalization of children, 1968 to 1970.


Pneumoperitoneum associated with chronic respiratory disease in the newborn.


Sampling procedures and problems in determining pesticide residues in the hydrologic environment.


Divergence of mouse brain interferon responses following virulent or avirulent Newcastle disease virus inoculation.


The effect of synthetic luteinizing hormone releasing hormone (LH-RH) on the protein synthesis of different hypothalamic areas and anterior pituitary gland.


Ovulation and serum luteinizing hormone in the cycling rat following administration of gonadotropin releasing hormone.


A radioimmunoprecipitation test for detection of Mycoplasma pneumoniae antibody.


5-Fluorocytosine resistance in candida spp. and Torulopsis glabrata.


Experimental candidal arthritis in the rabbit.


The treatment of cutaneous candidiasis in rabbits.


Postfixation and epoxy infiltration of large numbers of specimens in all-disposable containers for electron microscopy.


Hypertriglyceridemia and hypoglycemia in gram-negative sepsis in the dog.


The fate of the renal transplant with delayed function.


A life supporting heterotopic autotransplant of the canine liver without portal blood.


A technique for radical groin dissection.


Carotid endarterectomy for cerebrovascular ischemia.


Charles Gardner Child, 3d, M.D.

Charles Gardner Child, 3d, M.D.


The American Trauma Society--lessons learned from cancer and coronaries.


Major colonic diseases complicating renal transplantation.


Karl M. Dallenbach: 1887-1971.

Karl M. Dallenbach: 1887-1971.


Transplacental hog cholera infection in susceptible sows.


Precipitin test and soluble antigen fluorescent antibody technique for detecting Dirofilaria immitis in dogs.


Laryngeal seton.

Laryngeal seton.


Wilfred Batten Lewis Trotter 1872 to 1939. His legacy to pharyngeal surgeons.


The influence of DNA A and DNA C mutations on the initiation of plasmid DNA replication.


Regulation of sterol biosynthesis in yeast: induction of 3-hydroxy-3-methylglutaryl-CoA reductase by glucose.


FL-1060: a new penicillin with a unique mode of action.


RNA synthesis in Escherichia coli during K + -depletion.


In vitro in corporation of 2'-deoxyadenosine and 3'-deoxyadenosine into yeast tRNA Phe  using t-RNA nucleotidyl transferase, and properties of tRNA Phe -C-C-2'dA and tRNA Phe -C-C-3'dA.


The corrected nucleotide sequence of yeast leucine transfer ribonucleic acid.


Periodontal disease: is it microbial in origin?


Implant materials and their use in orthopedic surgery.


Viability of skin grafts stored in various media.


The measurement of pericardial effusion volume.


Current status of prolonged extracorporeal membrane oxygenation for acute respiratory failure.


Symptomatic venous compression from a mediastinal cystic lymphangioma.


Unilateral atelectasis in asthma.

Unilateral atelectasis in asthma.


Thoreau, pulmonary tuberculosis and dietary deficiency.


Serum enzymes in diabetes mellitus.

Serum enzymes in diabetes mellitus.


Selenium in the food chain.

Selenium in the food chain.


The Kikuchi--Enigk model of Strongylus vulgaris migrations in the horse.


Stability of polarity in the epidermis of a beetle, Tenebrio molitor L.


Effects of end-expiratory pressure on organ blood flow in normal and diseased dogs.


Effect of hydration and dehydration on elastic behavior of excised dogs' lungs.


Assessment of left heart function by noninvasive exercise test in normal subjects.


Pulmonary function and platelet-lung interaction.


Passive administration of antiserum and complement in producing anti-EL4 cytotoxic activity in the serum of C57BL-6 mice.


Immune response to Gross virus-induced lymphoma: comparison of two in vitro assays of cell-mediated immunity.


Porcine and ovine lymphosarcoma: a review.


DNA content of purified preparations of mouse Purkinje neurons isolated by a velocity sedimentation technique.


The isolation of cholinergic synaptic vesicles from bovine superior cervical ganglion and estimation of their acetylcholine content.


Potentiometric and colorimetric methods for the assay of 2',3'-cyclic nucleotide 3'-phosphohydrolase.


Congenital cystic malformation of the lung and its relation to hydramnios.


A double-blind study of intra-amniotic urea and hypertonic saline for therapeutic abortion.


Stereotactic hypothalamotomy for the alleviation of pain in malignant tumors.


Acute ferrous sulfate hepatotoxicity in rats. An electron microscopic and biochemical study.


Oxygen diffusion times in bacterial cells irradiated with high-intensity pulsed electrons: new upper limit to the lifetime of oxygen-sensitive species suspected to be induced at critical sites in bacterial cells.


A posteffect of oxygen in irradiated bacteria: a submillisecond fast mixing study.


Allergy in adverse drug reactions.

Allergy in adverse drug reactions.


Preliminary clinical trials with oxamniquine, a new antischistosomal agent.


Morphology of the nerve fibers in both normal and inflamed human dental pulp.


Herbert G. Birch 1918-1973.

Herbert G. Birch 1918-1973.


Future horizons of analytical electrochemistry in the neurophysiology of mental retardation.


Roentgenologic sequelae of neonatal septicemia and urinary tract infection.


Presidential address: the changing panorama of medical education.


Correlation of laboratory and clinical data during treatment of leprosy.


Benefits of methylprednisolone in the isolated perfused organ.


Emergency subtotal colectomy: preferred approach to management of massively bleeding diverticular disease.


Immune alterations in Hodgkin's disease. Effect of delayed hypersensitivity and lymphocyte transformation on course and survival.


Lithium prophylaxis in recurrent endogenous affective disorders.


Immunological competence of heat-treated extracts of tumor or lymph nodes.


Separation of aminoacyl-transfer RNAs by polyacrylamide gel electrophoresis.


Dimers of escherichia coli F' factors.

Dimers of escherichia coli F' factors.


Informational content of mitochondrial DNA from a "low density" petite mutant of yeast.


Two distinct poly(A) polymerases in yeast nuclei.


Sulfhydryl reactivity of E. coli DNA dependent RNA polymerase.


Transcription of chromatin by human RNA polymerase.


Comparison of DNA-binding proteins from mouse cells in culture.


Peptide chain initiation with chemically formylated Met-tRNAs from E. coli and yeast.


The effect of N,N'-dicyclohexylcarbodiimide on anaerobic and aerobic phosphate uptake by baker's yeast.


Studies on electron transport associated with photosystem I. II. Role of plastocyanin in methyl viologen photoreduction in French press-treated chloroplasts.


F-actin-heavy meromyosin complex studied by optical homodyne and heterodyne methods.


Oro-endotracheal intubation in the rat.

Oro-endotracheal intubation in the rat.


Passive immunity and its transfer with special reference to the horse.


Electrocardiogram interpretation by computer.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. I. Review of the present state of automated electrocardiogram interpretation.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. II. Some considerations relevant to the selection of ECG Program.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. IV. Suggested minimal performance requirements and methods of performance evaluation for computer ECG analysis programs.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. V. Suggested standards for instrumentation in computer processing of electrocardiograms.


Canadian Colloquium on Computer-Assisted Interpretation of electrocardiograms. 3. Present state of arrhythmia analysis by computer.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. VI. Importance of the electrocardiogram in populations outside the hospital.


Canadian Colloquium on Computer-Assisted Interpretation of Electrocardiograms. VII. Considerations relevant to a rational transition from the present system to automated ECG analysis.


Proposed guidelines for protocol studies. I. Introduction. II. Plasma cell myeloma. 3. Chronic lymphocytic leukemia. IV. Chronic granulocytic leukemia.


In vitro synthesis of RNA with "aggregate" enzyme, chromatin, and DNA from liver of methylazoxymethanol acetate-treated rats.


Contributions of the biological sciences to human welfare. IX. Natural resources.


Contributions of the biological sciences to human welfare. IV. Dental science.


Contributions of the biological sciences to human welfare. I. Introduction.


Contributions of the biological sciences to human welfare. VI. Population biology.


Contributions of the biological sciences to human welfare. 8. Marine sciences.


Contributions of the biological sciences to human welfare. V. Food.


Jean Baseilhac (Frère Côme) 1703-1781.

Jean Baseilhac (Frère Côme) 1703-1781.


Hyperacute renal allograft rejection in the human neonate.


New gonorrhea and old gonorrhea.

New gonorrhea and old gonorrhea.


Contributions of the biological sciences to human welfare. 3. Clinical medicine.


Contributions of the biological sciences to human welfare. II. Basic biomedicine.


Ringworm in Indian medicine.

Ringworm in Indian medicine.


Ovulation induced by synthetic luteinizing hormone releasing factor in androgen-sterilized female rats.


Psychiatric implications of industrialization and rapid social change.


The effect of a  -adrenergic blocker on insulin release from the isolated perfused pancreas of obese mice.


Malaria and the acute psychotic episode.


The admission process.

The admission process.


A reanalysis of female reactions to contraceptive sterilization.


Attempts to cultivate and determine the maximum period of viability of Mycobacterium leprae in tissue culture.


Immune response to M. leprae of healthy leprosy contacts.


Some ancient mysteries reexplored. 3. Grigori Yefimovich Rasputin.


Attempts to establish the Armadillo (Dasypus novemcinctus linn.) as a model for the study of leprosy. II. Histopathologic and bacteriologic post-mortem findings in lepromatoid leprosy in the Armadillo.


The origin of the names of elemental metals.


Subclavian-coronary artery bypass in man.


History, art, and a Congress, met in Tokyo.


The strange case of John Early. A study of the stigma of leprosy.


Forty-two month follow-up of a semilunar valve homograft to the mitral area. Report of a case.


Leprosy sketches from a chinese brush.

Leprosy sketches from a chinese brush.


Postirradiation treatments.

Postirradiation treatments.


A use for the Fogarty embolectomy catheter in hemostasis.


Simplified experimental unilateral pulmonary autotransplantation.


Scanning electron microscopy of canine lung transplants.


[Autopsy case of reticulum cell sarcoma of the chest wall which presented difficulty in diagnosis].


Absence of enhancing effect of trimethoprim on the activity of a sulfonamide against Mycobacterium leprae.


Calcium ions and muscle contraction.

Calcium ions and muscle contraction.


[State association past president dies (Horatio Thomas Pease)].


A multi-disciplinary catalogue of uric acid literature of interest to behavioural scientists.


Operant control of autonomic functions: biofeedback bibliography.


Trypanosoma lewisi: cell populations and antibody formation in riboflavin deficient rats.


Partial purification of the NADP-specific isocitrate dehydrogenase of Salmonella typhimurium and characterization of its inhibition by oxalacetate.


Transferable drug-resistance among Escherichia coli isolated from horses and horse-meat handlers.


Stereotaxic atlas of the toad's brain.

Stereotaxic atlas of the toad's brain.


The biological fate of decamethonium. In vivo and in vitro studies.


Aneurysm of the gastroduodenal artery presenting as common duct obstruction with jaundice. Review of literature.


Corrctive rhinoplasty. A study of 5,000 personal cases.


Storage stability of mixed hyperalimentation solutions.


Directory of otolaryngological societies.


Laryngeal reconstruction to prevent aspiration.


O studies on the oxidative and nonoxidative pentose phosphate pathways in wild-type and mutant Escherichia coli cells.


Use of photochemically induced cross-linking as a conformational probe of the tertiary structure of certain regions in transfer ribonucleic acid.


Molecular dissection of immunoglobulin G. Conformational interrelationships of the subunits of human immunoglobulin G.


Penicillin in the treatment of syphilis.


Early warning of rejection?

Early warning of rejection? The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), beta-galactosidase (GAL), beta-glucosidase (GLU), and alkaline phosphatase (AP) was studied in 83 patients with renal allografts. Thirty of these patients had stable graft function and their urinary enzyme levels provided a range of normal values. Urinary lactic dehydrogenase (LDH) was estimated in 29 normal subjects and in 11 patients with renal allografts. Serum values for the five enzymes were also obtained. Urinary NAG excretion was abnormally high in 16 out of 17 (94%) episodes of acute rejection. The other urinary enzymes were raised less frequently. In nine patients studied before the onset of rejection urinary NAG activity rose up to three weeks before changes in other tests of renal function. Serum enzyme levels were not found to be of value in the diagnosis of rejection.


Renal transplantation in leprosy.

Renal transplantation in leprosy.


New horizons in medical ethics. Severely malformed children.


Ventriculoperitoneal shunting for hydrocephalus. Revision rate and complications were reviewed in 297 patients of all ages subjected to ventriculoperitoneal shunting and adequately followed. Both operative mortality and deaths due to complications of this type of shunt were much lower than after ventriculocaval shunts. Although 44% required revision a third of the cases had a period of three years without revision; two-thirds of these went for three years after the initial operation without need for operation. This shunt should be considered both in children and in adults because it is no more likely to block than ventriculoatrial, is easier to revise, and the other complications are fewer and much less serious.


Multiple sclerosis: a review.

Multiple sclerosis: a review.


Acute appendicitis and salmonella infections.


Significance of milk pH in newborn babies.


An I.U.C.D. dating from 1890.

An I.U.C.D. dating from 1890.


Sickle-cell anaemia.

Sickle-cell anaemia.


Advertising of antibiotics.

Advertising of antibiotics.


Z. D. M. Malkiewicz, M.D.

Z. D. M. Malkiewicz, M.D.


Madeline Lockwood.

Madeline Lockwood.


W. L. Selkirk.

W. L. Selkirk.


D. C. Reavell.

D. C. Reavell.


A. M. Boyd.

A. M. Boyd.


Advice on heart transplants.

Advice on heart transplants.


J. R. Wheeler.

J. R. Wheeler.


W. W. Mackarell.

W. W. Mackarell.


Toxicology of di-2-ethylhexyl phthalate and other phthalic acid ester plasticizers.


Sensory studies in the cross-thumb pedicle flap.


Pollen wall proteins: pollen-stigma interactions in ragweed and Cosmos (Compositae).


Panoramic views of cells in tissue culture using an orbiting chamber.


Abolition by myosin and heavy meromyosin of the inhibitory effect of smooth-muscle actomyosin antibodies on cell aggregation in vitro.


Some effects of actinomycin D, cycloheximde and puromycin on cell adhesion.


A passel of "pseudo's".

A passel of "pseudo's".


Pulmonary nocardiosis. Therapy with minocycline and with erythromycin plus ampicillin.


The clinical morbidity of the first year of bereavement: a review.


Martin G. Goldner.

Martin G. Goldner.


Sodium-dependent sugar transport in the intestine.


Current status of diabetic neuropathy.

Current status of diabetic neuropathy.


Extraction and use of melanoma-associated protein for immunotherapy.


Gutta-percha root canal fillings. An in vitro analysis. I.


Projective aggression and social attitudes.


Synaptic ultrastructure in the tangential nucleus of the goldfish (Carassius auratus).


The study of E. coli ribosomal RNA by the terminal modification method.


Development of a vaginal preparation providing both prophylaxis against venereal disease and contraception.


Appraisal of the Treponema pallidum haemagglutination test.


A comparison of thermal and dye dilution methods of determining cardiac output.


Comparison of pressor and adrenergic responses derived from direct and indirect methods of cardiovascular testing.


Anasthesia for simultaneous bilateral nephrectomy.


The first fatal case of chloroform anaesthesia in Canada.


Shirodkar suture for cervical incompetence.


The immunopathology of epidermolysis bullosa acquisita. The acquired type of epidermolysis bullosa, epidermolysis bullosa acquisita, has a high incidence of associated systemic disorders. Two patients with epidermolysis bullosa acquisita were investigated by clinical, histochemical and immunologic methods. The histochemical findings confirmed earlier reported dermal changes. Both patients had in vivo IgG and the C(3) component of complement localized in the basement-membrane zone.


Extrinsic allergic alveolitis.

Extrinsic allergic alveolitis. Extrinsic allergic alveolitis is caused by the inhalation of small organic allergen particles by non-atopic subjects which provoke an allergic reaction, thought to be chiefly due to a type III mechanism, in the peripheral respiratory tissues. The clinical features are determined by the nature of exposure, the immunopathological mechanism(s) involved and the site of reaction in the lung. When the exposure is intermittent and intensive, febrile episodes with respiratory symptoms beginning after four to six hours are prominent, but when it is more continuous and less intensive they are not and the features are those of a chronic fibrosing lung disease. The diagnosis is important to make because management by the avoidance of exposure is followed by improvement. It is made by recognizing the clinical presentation, by identifying the source of allergen exposure and by obtaining supportive evidence from precipitin and skin tests, or from allergen inhalation tests or lung biopsy.


Toxicological findings in fatal poisonings.


The scientific development of clinical chemistry to 1948.


Conditional mutations affecting the cell envelope of Escherichia coli K-12.


Characterization of the F transfer cistron, traL.


Spread of disease by fecal-oral route in day nurseries.


Medi-Cal patient satisfaction in Watts.

Medi-Cal patient satisfaction in Watts.


Development of a utilization review casebook.


Application of a non-Bayesian approach to computer-aided diagnosis for upper abdominal pain.


Evaluation of a computer program for neurological screening.


The impact of computers on bio-medical research.


An on-line multi-instrument laboratory computer system.


Steroidogenesis and cell structure. Biochemical pursuit of sites of steroid biosynthesis.


Persistence of maternal antibody and its effect on the antibody production in young mice.


The influence of a great pathologist: a tribute to Ernest Goodpasture.


Relationship between physiological research and philosophy in the work of Pavlov and Sherrington.


William Preyer and the prenatal development of behavior.


Studies of oxidation phosphorylation in Saccharomyces cerevisiae and Saccharomyces carlsbergensis.


Hemispheric asymmetries in tachistoscopic information-processing.


Daisy Miller and the Roman fever.

Daisy Miller and the Roman fever.


The effect of chlorpromazine on preservation of kidneys with one hour of warm ischaemia.


Bumetanide, a new potent diuretic. A clinical evaluation in congestive heart failure.


Medical numismatic notes XI: commemorative medals issued at the international physiological congresses.


Alleged brevity of life in North America Kalm, Peter: Travels into North America, 2d. edition, Forster JR, translator. London, 1772, vol. 1, pp. 80-82.


The slums of New York City. Report of the Council of Hygiene and Public Health of the Citizen's Association of New York upon the sanitary conditions of the city. New York, Appleton, 1865.


Studies on the conversion of proinsulin to insulin in the isolated islets of Langerhans in the rat.


Autoimmune disorders and malignant lymphoma.


Analogies between experimental and human lymphoma cutis.


Cooperative clinical trials in primary breast cancer: a critical appraisal.


Cerebrovascular disease.

Cerebrovascular disease.


Renin and hypertension: a review article.


Problems in temperature regulation and exercise. Introduction (Robert Winslow Bullard).


Enhancement of the humoral immune response by vitamin E.


Studies on antibody response and tolerance to E, coli K antigens in immunized rabbits and in children with urinary tract infection.


Intensive chemotherapy in patients with generalized Burkitt's lymphoma.


Sexual dimorphism in the primary immune response of the Syrian hamster.


A dietary  approach to coronary artery disease.


Triglyceridemia.

Triglyceridemia.


The treatment of pannus in dogs by use of a corneal-scleral graft.


Minerals in cardiovascular disease.

Minerals in cardiovascular disease.


Serologic diagnosis of toxoplasmosis and prevalence of Toxoplasma gondii antibodies in selected feline, canine, and human populations.


Inherited disorders causing infertility in the bull.


The selenium dilemma.

The selenium dilemma.


Requinomycin, an inhibitor of R-factor transfer: isolation, characterization and properties.


Enhancement of lung preservation by prevention of lung collapse.