Urea carboxylase from Saccharomyces cerevisiae. Evidence for a minimal two-step reaction sequence.


Irreversible inhibition of the interaction between elongation factor Tu and phenylalanyl transfer ribonucleic acid by L-1-tosylamido-2-phenylethyl chloromethy ketone.


Separation of HeLa cells by colloidal silica density gradient centrifugation. I. Separation and partial synchrony of mitotic cells. Using a colloidal silica density gradient, HeLa cells in mitosis were found to have a density of 1.040-1.046 g/cc, lighter than the remaining interphase cells. The mitotic cells could be harvested and cultured after centrifugation, showing growth synchrony by measurement of a peak in mitotic index 21 hr after establishing the culture. By using Colcemid or vinblastine sulfate, HeLa cells were arrested in metaphase and centrifuged on the colloidal silica density gradient. The blocked metaphase cells were lighter in density than the interphase cells but somewhat more dense than untreated cells selected by the density gradient centrifugation. Near-equilibrium conditions were established during the centrifugation of cells so that cell density measurements could be made, and the gradient medium employed was not measurably toxic to those cells tested.


The organization of ribosomal granules within mitochondrial structures of aerobic and anaerobic cells of Saccharomyces cerevisae.


The process of infection with coliphage T7. VII. Characterization and mapping of the major in vivo transcription products of the early region.


Changes in chromatin template activity and their relationship to DNA synthesis in mouse parotid glands stimulated by isoproterenol. Chromatin template activity of mouse parotid glands increases after a single injection of isoproterenol (IPR), a procedure that causes, after a lag period of 20 hr, a marked stimulation of DNA synthesis and cell division in salivary glands of rodents. The increase in chromatin template activity occurs as early as 1 hr and peaks between 6 and 10 hr after IPR, paralleling previously reported changes in the incorporation of uridine-(3)H into total cellular RNA of mouse parotids. Template activity was measured in vitro in a system in which parotid gland chromatin was incubated with an exogenous RNA polymerase isolated from Escherichia coli. Similar results were obtained when template activity of parotid gland chromatin was assayed using an homologous RNA polymerase from mouse liver. Chromatin template activity in mouse parotids was also studied after the administration of drugs capable of inducing in salivary glands both DNA synthesis and secretion or secretion alone. The results indicate that the increased chromatin template activity occurring 6 hr after IPR is related to the subsequent onset of DNA synthesis. Furthermore, the increased chromatin template activity caused by IPR is inhibited by the previous administration of puromycin, an inhibitor of IPR-stimulated DNA synthesis.


Substructure of the myosin molecule. 3. Preparation of single-headed derivatives of myosin.


Tritium exchange studies of transfer RNA in native and denaturated conformations.


High resolution nuclear magnetic resonance study of base pairing in the native and denaturated conformers of transfer RNA Leu  3 .


Escherichia coli initiation factors: isolation of an IF2-fMet-transfer RNA complex.


Etiology of human breast cancer: a review.


Tumor immunity to murine plasma cell tumors. I. Tumor-associated transplantation antigens of NZB and BALB-c plasma cell tumors.


Neuraminidase, sialic acids, and cell interactions.


Editorial.

Editorial.


Infectivity of leprosy bacilli from bone marrow and liver of patients with lepromatous leprosy.


The distribution of Mycobacterium leprae in different structures of the skin.


The foot cell morphology of genus Aspergillus.


In-vitro susceptibility of Candida albicans and Candida stellatoidea to sulfamethoxazole.


Survival of patients undergoing chronic hemodialysis and renal transplantation.


Foundation for medical care control of hospital utilization: CHAP--a PSRO prototype.


Sodium and diuretics in pregnancy.

Sodium and diuretics in pregnancy.


5-Fluorouracil in the treatment of gastrointestinal neoplasia.


Catch-up growth in celiac disease.

Catch-up growth in celiac disease.


Energy production during exercise.

Energy production during exercise.


Menkes's kinky hair syndrome.

Menkes's kinky hair syndrome.


Tissue biosynthesis of prostaglandins.

Tissue biosynthesis of prostaglandins.


Mercury toxicity reduced by selenium.

Mercury toxicity reduced by selenium.


Factors of whey affecting lactose metabolism.


Beta cells and glucose in diabetes.

Beta cells and glucose in diabetes.


Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.


Sex-related resistance in hamsters to adenovirus oncogenesis.


Biologic parameters of adenovirus transformation.


Interactions of adenovirus type 12 with host cell chromosomes.


Alterations in hamster cell regulatory mechanisms resulting from abortive infection with an oncogenic adenovirus.


Oncogenic and nononcogenic mutants of adenovirus 12: induction of chromosome aberrations and cell divisions.


Bovine adenoviruses.

Bovine adenoviruses.


Canaliculi and tubulovesicles of rat parietal cells.


Care of the patient undergoing valvular heart surgery.


Clinical aspects of rheumatic valvular disease.


Isolation of bacillus HB-1 from human clinical sources.


Comparison of three anaerobic systems for the isolation of anaerobic bacteria from clinical specimens.


Subacute bacterial endocarditis caused by Eubacterium aerofaciens: report of a case.


Epidemiology of infectious and non-infectious disease: some comparisons.


Blood coagulation studies in Plasmodium falciparum malaria.


Metabolic effects of contraceptive steroids.


Radiotherapy of advanced carcinoma of the oropharyngeal region under hyperbaric oxygenation. An interim report.


Whole body and partial body radiotherapy of advanced cancer.


Frank A. Riebel, M.D., 1903-1972.

Frank A. Riebel, M.D., 1903-1972.


A noninvasive technique for use in cardiovascular mass surveys.


Colicinogeny of Salmonella enteritidis strains isolated in the Wroclaw Province.


The Royal College of Surgeons in Ireland. Abraham Colles (1773-1973) bicentenary celebrations.


The effect of zygosity on the birth weight of twins.


The effect of pokeweed mitogen administration on the primary antibody response to sheep red cells in the spleen of mice as determined by a plaque assay.


Morphological and ecological characteristics of Spirochaeta plicatilis.


Observations on the ultrastructure of flagellar scales in the genus synura (chrysophyceae).


The antigenic structure of escherichia coli and Shigella flexneri hybrids.


Modifications of the lysosomal enzymes of the macrophages in mice inoculated with purified Plasmodium berghei antigen.


Immune responses in intestinal tissues to particulate antigens. Plaque-forming and rosette-forming cell responses in rats.


The effect of the plating medium on the recovery of nonsense suppressors in Saccharomyces cerevisiae.


Transcription of brain chromatin by ribonucleic acid polymerases from brain nuclei and from Escherichia coli. 1. Transcription of ox brain chromatin by brain nuclear RNA polymerase II and Escherichia coli RNA polymerase was studied. 2. The soluble chromatin prepared from brain nuclei contained DNA, RNA, histone and non-histone proteins. Such chromatin preparations did not display any endogenous RNA polymerase activity, when assayed in the presence of concentrations of KCl as high as 0.4m. 3. The chromatin-templated activity of brain nuclear polymerase II was stimulated by KCl, with an optimum around 0.25m. 4. The template activity of brain chromatin for brain nuclear polymerase II and E. coli enzyme was about 20-25% of that of pure DNA. This greatly repressed templatecapacity of chromatin was probably due to the acid-soluble chromosomal proteins. 5. Brain nuclear polymerase II was 3-4 times more active with dehistonized chromatin than with pure DNA as template, whereas bacterial enzyme was almost equally active with either of these two templates, reflecting the specificity of the transcriptional control mechanisms in mammalian cells.


Deoxyribonucleic acid synthesis in mammalian systems. Permealysed Ehrlich ascites cells in vitro first label Okazaki-type low-molecular-weight deoxyribonucleic acid and then high-molecular-weight deoxyribonucleic acid. During the evaluation of a method of preparing permealysed Ehrlich ascites cells, shortterm labelling experiments were carried out with d[(3)H]TTP. In the first minute the bulk of the label appeared as low-molecular-weight pieces of DNA. Subsequently the label appeared in DNA of much higher molecular weight. A brief description of the preparation procedure and the properties of the product is provided. Evidence is presented to show that the nucleotide was incorporated directly without intermediate conversion into dTMP or thymidine.


Mental onlay bone grafts in Angle's Class II malocclusions: a preliminary study.


The fibrin stabilizing factor, factor XIII.


James Coulter Smyth, O.B.E., F.F.D., L.R.C.P. & L.M., L.R.C.S. & L.M.


Relieve the wheel and lookout.

Relieve the wheel and lookout.


Controlled evaluation of intravenous drugs in the specific desensitization of phobias.


Lily Mary Veronica Chan.

Lily Mary Veronica Chan.


Influence of lithium carbonate on patients with temporal epilepsy.


Influence of autosome movements and of sex-chromosome movements on sex-chromosome segregation in crane fly spermatocytes.


Light and electron microscopy of rat kangaroo cells in mitosis. II. Kinetochore structure and function.


Reduced migration capacity in vitro of peritoneal exudate cells from adult thymectomized, irradiated and bone marrow-protected rats.


Appearance of actin in embryos of Rana temporaria studied by immunofluorescence.


Considerations in providing psychiatric services in general hospitals.


Toxicity of dimethyl sulphoxide to plaque-forming cells.


Some observations on congenital malformations.


Computer-aided differential diagnosis of goitres in internal medicine.


Simplified data input: an experiment in general practice morbidity recording.


Differential inhibitory effects of cholera toxoids and ganglioside on the enterotoxins of Vibrio cholerae and Escherichia coli. Natural cholera toxoid appears to act as a competitive inhibitor of cholera enterotoxin and is thus a useful tool for studying the interaction of cholera enterotoxin with cell membranes. Cholera enterotoxin binds to gut mucosa more rapidly than does its natural toxoid. Once binding occurs, however, it appears to be prolonged for both materials. Formalinized cholera toxoid has no inhibitory effect upon cholera enterotoxin. Enterotoxic activity, ability to bind to gut mucosa, and antitoxigenicity appear to be independent properties of cholera enterotoxin. Natural cholera toxoid does not inhibit Escherichia coli enterotoxin, indicating that although the two enterotoxins activate the same mucosal secretory mechanism they occupy different binding sites in the mucosa. Ganglioside, which may be the mucosal receptor of cholera enterotoxin, is highly efficient in deactivating cholera enterotoxin. By contrast, ganglioside is relatively inefficient in deactivating heat-labile E. coli enterotoxin and is without effect upon the heat-stable component of E. coli enterotoxin. These findings suggest that ganglioside is not likely to be the mucosal receptor for E. coli enterotoxin. Differences in cellular binding of E. coli and cholera enterotoxins may explain, at least in part, the marked differences in the time of onset and duration of their effects upon gut secretion.


Monospecificity of bone marrow-derived lymphocytes.


Blocking and redistribution ("capping") of antigen receptors on T and B lymphocytes by anti-immunoglobulin antibody. Antigen-binding T and B lymphocytes were studied by combined autoradiography and immunofluorescence; mouse spleen lymphocytes binding the antigens, [(125)I]MSH or [(125)I]TIGAL, were incubated with rhodamine-labeled anti-Ig reagents or with a rhodamine-labeled IgG fraction of anti-theta serum. B cells were identified as Ig+ or theta-, T cells as Ig- or theta+. It was found that: (a) 20% (1-2 mo after priming) to 30% (3.5-4 mo after priming) of the antigen-binding cells were T cells. (b) The range of antigen molecules bound by B and T cells was similar. (c) Binding of antigen to B and T cells was inhibited by polyvalent anti-Ig, anti-micro, or anti-L reagents. Binding to T cells was more readily inhibited than to B cells. Normal rabbit serum, antimouse lymphocyte serum, or anti-theta did not inhibit antigen binding. (d) When Ig at the surface of B cells was induced, by noninhibiting concentrations of anti-Ig reagents, to redistribute into polar caps and the cells subsequently exposed to [(125)I)antigen under noncapping conditions, the [(125)I]antigen silver grains were distributed in caps superimposed on the Ig fluorescent cap. Of crucial importance, antigen was found in cap in the same proportion of T cells as B cells. Significant capping of antigen receptors was not induced in B or T cells with normal rabbit serum or by anti-Ig reagents absorbed with mouse Ig. The main conclusions of this series of experiments using direct visualization of antigen-binding B and T lymphocytes is that T cells have antigen-specific receptors, probably of IgM nature, and that the number of these receptors appears to range in the order of thousands.


The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule. Lipopolysaccharides with different structure, isolated from different mutant strains of Escherichia coli and Salmonella bacteria, and chemical degradation products of these lipopolysaccharides have been employed to investigate which part of the lipopolysaccharide molecule exerts mitogenic effects on bone marrow-derived mouse lymphocytes. Within the structure of lipopolysaccharide consisting of lipid A, a core polysaccharide, and the O-polysaccharide antigen, lipid A was found to be the mitogenic part. The mitogenic effect of lipid A, consisting of phosphorylated glucosamine disaccharide units with ester- and amide-linked fatty acids, was lost after alkali treatment, which removes ester-linked fatty acids. Insertion of the lipid A portion of lipopolysaccharides into the lipid bilayer of the plasma membranes of bone marrow-derived lymphocytes is discussed as the initial mitogenic action.


Restriction of specificity in the precursors of bone marrow-associated lymphocytes. Previous work has shown that the immediate precursor of B lymphocytes (PB cell) has many properties that distinguish it from both B lymphoctes and hemopoietic stem cells. Size, density, tissue distribution, and sensitivity to cytotoxic antisera differ for each type of cell. The work described here was designed to study three aspects of the differentiation of PB cells. First, since PB cells probably have immunoglobulin surface receptors, fluorescein-labeled anti-immunoglobulin antiserum was used in an attempt to investigate directly the physical properties of PB cells. The use of this labeled antiserum revealed a population of cells with properties similar to the PB cells defined by the functional assays. Second, the differentiative potential of PB cells was studied by comparing the size of the total population of PB cells, as determined with fluorescein-labeled anti-immunoglobulin antiserum, to the size of the population of PB cells responding in a functional assay with a specific antigen. The cells responding in the functional assay represent only 0.1% of the total population of PB cells. This observation suggests that PB cells are not pluripotent stem cells of the immune system. Finally, the kinetics of the differentiation of PB cells to B lymphocytes was studied. The differentiation to mature lymphocytes involves at least one intermediate stage in which cells larger than mature B cells are active in a functional assay for B cells. These large B cells are present in irradiated mice soon after transplantation of PB cells, but by 20 days the majority of the B cells are typical small lymphocytes.


Biological effects of cigarette smoking in the pathogenesis of pulmonary disease.


The allogeneic effect in inbred mice. 3. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo. The allogeneic effect has been shown to replace the requirement for carrier-specific helper thymus-derived (T) lymphocytes in secondary antihapten antibody responses in guinea pigs or mice. Attempts to enhance primary antibody responses to either 2,4-dinitrophenyl (DNP)-keyhole limpet hemocyanin (KLH) or DNP-ovalbumin (OVA) by the allogeneic effect have failed, and frequently result in suppression. However, the present studies have demonstrated a clear allogeneic effect on primary anti-DNP responses to a DNP-conjugate of the copolymer of D-glutamic acid and D-lysine, DNP-D-GL. This compound, for which no carrier-specific helper T cells exist, normally induces a state of DNP-specific tolerance in the doses employed. However, normal (BALB/c x A/J)F(1) recipients developed primary anti-DNP antibody responses, and of the IgG class, when DNP-D-GL was administered shortly after the transfer of allogeneic parental A strain lymphoid cells. To test the possibility that the presence of KLH-specific T lymphocytes might inhibit the expression of the allogeneic effect on the primary response to DNP-KLH, studies were undertaken using T cell-depleted spleen cells. In this model, the allogeneic effect again enhanced the primary response to DNP-D-GL, but still failed to enhance the primary response to DNP-KLH. These studies indicate that the structure of the molecule employed and its specific interaction with the bone marrow-derived (B) cell membrane may be critical in the capacity of primed and unprimed B cells to be influenced by the allogeneic effect.


Identification of asbestos in human tissues.


Biologic response to kind and amount of asbestos.


Pharmacologic evaluation of tolectin (tolmetin, mcn-2559) and mcn-2891, two anti-inflammatory agents.


Spectral, chemical and template properties of mouse and rat uterine chromatin after in vivo administration of estradiol.


Partial purification of a tumor tRNA-guanine methyltransferase.


Victor Roy Harbison.

Victor Roy Harbison.


Albert Ray Southwood.

Albert Ray Southwood.


Malignant lymphoma. 2.

Malignant lymphoma. 2.


Digitalis glycosides. 2.

Digitalis glycosides. 2.


Cheyne-Stokes breathing. An instability in physiologic control.


Community nursing services accredited by NLN-APHA, April 1973.


The effect of gastric secretions on iron attachment to the small intestine.


A method for the isolation of Naegleria species from water samples.


The palaeopathology of bone disease.

The palaeopathology of bone disease.


A five-year clinical trial of indomethacin in osteoarthrosis of the hip.


Antifibrinolytic control of menorrhagia after I.U.D. insertion.


A phenothiazine in spasticity.

A phenothiazine in spasticity.


The Perth dispensaries: 1819-1838.

The Perth dispensaries: 1819-1838.


Hansen's bacillus. Gerhard Henrik Armauer Hansen (1841-1912).


Institute for Clinical annd Experimental Medicine.


Computer-based fluid and electrolyte consultation. Initial clinical impressions.


Imported malaria in Cape Town.

Imported malaria in Cape Town.


Open reconstruction of the mitral valve.


Technique of renal transplantation.

Technique of renal transplantation.


Technique for ureteroneocystostomy in renal transplantation and reflux.


Operations for sterilization of the female.


Mesh skin grafts in the management of open fractures with skin defects.


Immunofluorescence in chronic nonhereditary blistering disease.


In memory of Andrzej Gluszcz.

In memory of Andrzej Gluszcz.


The in vitro activity of nitroxoline against organisms isolated from dogs and cats.


A third outbreak of type C botulism in broiler chickens.


Bacteriophage P4: a satellite virus depending on a helper such as prophage P2.


Structural proteins of bacteriophage T5.


A component mutation of virB virulence affects lysogenization by phage P22.


The map position of the immunity (imm) gene of bacteriophage T4.


Rejection of renal allografts in sensitized and non-sensitized dogs.


The accumulation and distribution of platelets and fibrin in rejecting dog kidneys.


Testing the 'preliminary criteria for classification of SLE'.


Double-blind comparison of aspirin and 4-(acetamido) phenyl-2-acetoxy-benzoate (benorylate) in rheumatoid arthritis.


Measurement of inflammation. II. Comparison of technetium clearance and thermography with standard methods in a clinical trial.


Urinary diversion in children.

Urinary diversion in children.


Some physiological and clinical aspects of puberty.


Terbutaline in children with asthma.

Terbutaline in children with asthma.


Studies on in vitro DNA synthesis. II. Isolation of a protein which stimulates deoxynucleotide incorporation catalyzed by DNA polymerase of E. coli.


Recognition of altered E. coli formylmethionine transfer RNA by bacterial T factor.


Genetic transformation in E. coli: the inhibitory role of the recBC DNase.


Affinity labeling of isoleucyl-tRNA synthetase with N-bromoacetylisoleucyl-tRNA.


Transcriptive complex: isolation by cesium sulfate-centrifugation.


Initiation factor 3 requirement for the formation of initiation complexes with synthetic oligonucleotides.


A new form of RNA polymerase isolated from Escherichia coli.


Distribution of carboxylation and decarboxylation enzymes in isolated mesophyll cells and bundle sheath strands of C 4  plants.


An Aspergillus nidulans mutant lacking cystathionine  -synthase: identity of L-serine sulfhydrylase with cystathionine  -synthase and its distinctness from O-acetyl-L-serine sulfhydrylase.


Phospholipase activity associated with serum albumin.


Portal blood flow and heat production in the digestive tract of sheep.


Mechanical sutures in surgery.

Mechanical sutures in surgery.


Leukemic phase of reticulum cell sarcoma (histiocytic lymphoma). A clinicopathologic and ultrastructural study.


Disopyramide (Rythmodan) for arrhythmias?


Properties of excitatory and inhibitory regions in the receptive fields of single units in the cat's superior colliculus.


Evaluation of certain food additives and of the contaminants mercury, lead and cadmium.


Study into the mechanisms of damage of human placental syncytiotrophoblast. II. Histologic comparison of plasma-induced damage and specific enzymes-induced damage.


Histochemical tests on lipids in the oral and skin epithelium in the mouse.


The primary and secondary antibody response to Escherichia coli O6 lipopolysaccharide analysed at the humoral and cellular level. Amount and avidity of the antibodies in relation to protective capacity.


B and T lymphocytes in primary immunodeficiency disease in man. B- and T-cell populations in 32 patients with different forms of primary immunodeficiency disease were studied. The B-cells in peripheral blood were investigated with respect to surface immunoglobulins by means of immunofluorescence. The T-cell function was studied utilizing quantitation of proliferative response to phytochemagglutinin (PHA)(1) and delayed allergy to various antigens. In 10 patients lymph node lymphocytes were also evaluated 11 male children with infantile x-linked agammaglobulinemia were divided into two subgroups. One did not show immunoglobulin spots on peripheral blood lymphocytes at all, the other contained a very low percentage of IgM- and occasionally IgA bearing lymphocytes. Eight patients with common variable immunodeficiency had moderately decreased percentages of peripheral blood and lymph node lymphocytes with surface immunoglobulins, but these patients lacked immunoglobulin secreting cells. Four cases of isolated IgA deficiency had normal or high percentages, and two cases of ataxia-telangiectasia had high percentages of lymphocytes with IgA in so called receptor distribution in both peripheral blood and lymph nodes. In three patients with infantile combined immunodeficiency that had been corrected by marrow transplantation, the percentages of Ig-bearing lymphocytes increased to normal or high levels together with establishment of functional T-cell population and ultimate secretion of serum immunoglobulins. One case of Di George syndrome reconstituted by fetal thymus transplant showed gradual decrease of B lymphocytes in circulation parallel to restoration of T-cell population.


Measurement of digestibility of alfalfa protein concentrates by in vivo and in vitro methods.


Exaggerated carbohydrate-induced calciuria in the remaining kidney of transplant donors.


A dye-dilution cardiac output technique for hemodialyzed patients with arteriovenous fistula.


A clinical evaluation of the new dialysers.


Computer technology in medical education.


Current problems in infective endocarditis. With special reference to cases acquired in hospital or after cardiac surgery.


Transient virus infection: spontaneous recovery mechanism of lymphocytic choriomeningitis virrus-infected cells.


W. C. Roentgen, his friendship with Ludwig Zehnder.


Modified treatment of neonatal tetanus.

Modified treatment of neonatal tetanus.


Carlos Monge M., Dec. 13, 1884-Feb. 15, 1970.


Walter E. Garrey, 1874-1951.

Walter E. Garrey, 1874-1951.


Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations.


Rationale and early experience in assisted circulation.


Present status of drugs as teratogens in man.


The microscope and leprosy.

The microscope and leprosy.


The use of hyperbaric oxygenation in conjunction with membrane lung perfusion for respiratory insufficiency.


Gastric fundoplications in esophageal surgery other than hiatal hernia repairs. A review of experimental studies and clinical applications.


Ribosomal binding site of fMet-tRNA in Escherichia coli system directed by phage f2 RNA.


Comparative studies on ornithine carbamoyltransferase.


Electrophoretic identity of biologically active pituitary and serum prolactins in the lactating and perphenazine-treated rat.


Quantitative bacterial culture of urine. II. Evaluation of 10 different screening methods for the diagnosis of bacteriuria compared with results obtained by the dilution technique.


Extracorporeal irradiation of the blood. Clinical results after necro-kidney transplantation.


Effect of alprenolol on blood pressure and plasma renin activity in hypertensive patients.


Corrective surgical office procedures of the face.


Yeast in the urine.

Yeast in the urine.


Demonstration of bovine syncytial viral antigen in bovine lymphocyte cultures by immunofluorescence.


Daniel Murnane, E.D., D.V.Sc., F.A.C.V.Sc.


The immunology of streptococcal infections.


Mechanisms of immunity to intestinal helminths.


Function of nerves of the heart.

Function of nerves of the heart.


In vitro studies on transplantation immunity. II. The migration inhibition in homograft reactions in guinea pigs.


Adaptive transfer of neonatally induced tolerance into normal mice.


Rheumatoid factors in rheumatoid arthritis.


Binding of putrescine and spermidine to ribosomes from Escherichia coli.


Biology of surgical infection.

Biology of surgical infection.


Neurologic disorders in neonates associated with abnormalities of pregnancy and birth.


Deoxyribonucleoside-triphosphate pools and DNA synthesis in synchronized hamster cells.


Molecular morphology of ribosomes. Localization of ribosomal proteins in 50-S subunits.


The binding of ethidium bromide to different conformations of tRNA. Unfolding of tertiary structure.


Structure and function of the genome of coliphage T5. 1. The physical structure of the chromosome of T5 + .


Biosynthesis of melittin, a toxic peptide from bee venom. Amino-acid sequence of the precursor.


Effect of spermine on the binding of erythromycin to Escherichia coli ribosomes and the peptidyl-transfer reaction.


The use of splintage in the management of paralytic dislocation of the hip in spina bifida cystica.


Peter Islwyn Hywel-Davies, 1914-1972.

Peter Islwyn Hywel-Davies, 1914-1972.


Henry George Lowe, 1923-1972.

Henry George Lowe, 1923-1972.


John Dennis Wilson, 1911-1972.

John Dennis Wilson, 1911-1972.


George Perkins.

George Perkins.


Twenty-five years of hand surgery. Personal reflections.


A routine method for embedding animal tissues in Spurr resin for electron microscopy.


An effect of the ion phenotype in Escherichia coli as indicated by the growth of amoebae of Dictyostelium discoideum.


Reassessment of maintenance and energy uncoupling in the growth of Azotobacter vinelandii.


Colicin factors and mitomycin-C.

Colicin factors and mitomycin-C.


R factors conferring resistance to trimethoprim but not sulphonamides.


Measurement of digitalis glycosides in human serum.


Loss and restoration of viability of E. coli due to combinations of mutations affecting DNA polymerase I and repair activities.


Localization of some 5s RNA cistrons on Escherichia coli chromosome.


RNA polymerase mutants of Escherichia coli. Streptolydigin resistance and its relation to rifampicin resistance.


Prophylactic anticoagulant therapy in the prevention of calf-vein thrombosis after myocardial infarction.


Vivere natura--natura duce.

Vivere natura--natura duce.


For lower blood-transfusion units.

For lower blood-transfusion units.


More on tight girdles.

More on tight girdles.


Preliminary x-ray analysis of the crystalline complex between poypeptide chain elongation factor, Tu, and GDP.


The composition of the body: its maintenance and regulation.


Changing concepts in academic medicine.

Changing concepts in academic medicine.


Pelvic exenterations in gynecologic cancer.


The treatment of corneal transplantations with imuran.


Localization of corneal antigens.

Localization of corneal antigens.


In memoriam: Professor Alexander Symeonidis (1909-1972).


Morphological study of a case of lung transplantation with 10 months survival.


Cell alterations of the gastric mucosa in benign diseases and malignant tumors.


Ultrastructure of peliosis hepatis in a percutaneous biopsy.


Immunohistochemical studies of liver tissues.


Afferential integration.

Afferential integration.


Sutureless hemorrhoidectomy.

Sutureless hemorrhoidectomy.


Detection of malarial antibodies by counter current immunoelectrophoresis.


Heavy meromyosin binding to microfilaments involved in cell and morphogenetic movements.


Vertebral column of the Australian aborigine: selected morphological and metrical features.


Bobba Hannah, midwife.

Bobba Hannah, midwife.


A method for preventing inadvertent dislodging of drains.


Total sternal resection and reconstruction using bone grafts and fascia lata.


Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis.


Trimethoprim-sulfamethoxazole: pharmacodynamic effects of urinary pH and impaired renal function. Studies in humans.


Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections.


Early uses of outpatient.

Early uses of outpatient.


Evaluation of a previous mass campaign against endemic syphilis in Bosnia and Herzegovina.


Consumption of antibiotics in Greenland, 1964-1970. I. Economic and epidemiological considerations.


Consumption of antibiotics in Greenland, 1964-1970. II. Effect of coincidental administration of antibiotics on early syphilitic infections.


Consumption of antibiotics in Greenland, 1964-70. 3. Effect of coincidental administration of antibiotics on gonorrhoeal infections.


Treatment of gonorrhoea with single injections of gentamicin.


Hospital facilities for, and diagnosis and treatment of, venereal disease in England, 1800-1870.


A simplified method for the in vitro calibration of electromagnetic flowmeters.


Kappa, a novel factor for the arrest of transcription in vitro by DNA-dependent RNA polymerase from Escherichia coli at specific sites of natural templates.


A model for the initiation of transcription by DNA-dependent RNA polymerase from Escherichia coli.


The effects of ionic strength on termination of transcription of DNAs from bacteriophages T4, T5 and T7 by DNA-dependent RNA polymerase from Escherichia coli and the nature of termination by factor rho.


Further studies with labelled polypeptide-chain-initiation factor 3 (IF-3).


A contribution to the history of gerontology.


A 5-year follow-up of bacteriuria in the aged.


Partition of proteins in two-phase systems containing charged poly(ethylene glycol).


Severe degloving injury of upper limb.

Severe degloving injury of upper limb.


William Frame White, F.R.C.S. (Edinburgh), F.R.F.P.S. (Glasgow).


Anaerogenic variant of Salmonella typhimurium causing pyogenic meningitis. A case report.


Dr. K. Raman.

Dr. K. Raman.


Fluorophotometric recording of fluorescein dilution curves in human retinal vessels.


Jules Holzberg.

Jules Holzberg.


Psychotherapy as a means of social control.


A catalogue of the zoonoses of Taiwan.

A catalogue of the zoonoses of Taiwan.


Studies on transmission of Staphylococcus aureus in an isolated ward for burned patients. A one-year epidemiological investigation was made in an isolation ward for burned patients. The transmission of Staphylococcus aureus was mainly studied. In spite of the design of the ward the cross-infection rate was high. In all, 49 of 69 patients were infected 114 times. Twenty-six of the strains causing infection were found in a patient only, 10 in a member of the staff only and 23 in both patients and staff the week before they caused a new infection. There were three epidemic outbreaks caused by three strains of Staph. aureus all belonging to phage group III; one was resistant to methicillin. Environmental studies with settle plates showed that the number of staphylococci dispersed by a burned patient was often very high. In 8% of the observations in occupied bedrooms the air count of Staph. aureus was more than 1800 col./m.(2) hr. However, the counts of Staph. aureus in the corridor and service areas were low. This seems to indicate a rather good protection against airborne transfer of bacteria. Other routes of infection were probably of greater importance.


The post-mortem diagnosis of influenzal infection by fluorescent IgG, IgA and IgM antibody studies on necropsy blood. Necropsy blood from cases diagnosed as dying from influenza A was examined for specific antibody in the IgG, IgA and IgM fractions and a specific diagnosis of recent infection was made if either IgM or IgA antibody and low titres of IgG antibody were found. By these criteria a diagnostic rate of 77% was found in those cases from whom no virus was isolated. The use of infected cell monolayers grown on polytetrafluoroethylene-coated slides gave a simple method of carrying out these antibody assays, and the use of necropsy blood did not require any special methods of transport of specimens to the virus laboratory.


Aerobic bacteria occurring in the hind-gut of the cockroach, Blatta orientalis. Methods are described for the isolation and identification of aerobic bacteria occurring naturally in the hind-gut of the cockroach Blatta orientalis captured from a number of wild sources, to establish whether or not human pathogens occurred naturally within the gut. During the investigation an organism was frequently found which could not be classified in any described species, and for which we propose the name Escherichia blattae.


H phase change of Salmonella thompson at different temperatures. H phase II --> phase I conversion of Salmonella thompson was studied at different temperatures. All strains were isolated from one outbreak, and a convenient method of phase conversion was sought. In our hands this was best effected at 20 degrees C.


Laboratory transmission of enterobacteriaceae by the oriental cockroach, Blatta orientalis. Methods of maintaining and feeding and of infecting cockroaches with pathogenic organisms were investigated.Cockroaches fed on known concentrations of Escherichia coli O119, Esch. coli O1, Alkalescens Dispar O group 2 and Shigella dysenteriae 1 (Shiga's Bacillus) were maintained in Petri dishes. The effect of various diets on the survival of these organisms within the hind-gut and faeces was observed. With a ;normal' diet of gruel Esch. coli O119 was isolated for up to 20 days, Esch. coli O1 for 17 days and ADO 2 for 15 days. Sh. dysenteriae 1 was isolated only sporadically to the third day.


Electroconvulsive therapy and schizophrenia.


Modern trends in pediatric cardiology.

Modern trends in pediatric cardiology.


Ultrastructure of rhinosporidium seeberi.


Experimental cerebral revascularization with autogenous grafts.


Electrophysiological topography of the human diencephalon.


Localization of intraventricular arteriovenous malformations by ventriculography combined with stereoscopic arteriography. Technical note.


In memorian Professor Dr. phil. Dr. med. h.c. Georg v. Békésy.


The place of home dialysis in a comprehensive renal replacement programme.


Home haemodialysis as part of a comprehensive renal replacement programme.


"This won't hurt". Minimizing the morbidity of surgery in infancy and childhood.


The costs of domiciliary maintenance haemodialysis. A comparison with alternative renal replacement regimens.


Dr. John Alfred Carr. A psycho-historical study.


Sir Colin MacKenzie and his contribution to the treatment of poliomyelitis.


Radial diffusion effects in a finite extravascular space surrounding a single capillary.


T and B lymphocytes and immune responses.


A new hypothalamic pathway to the median eminence containing neurophysin and its hypertrophy in sheep with natural scrapie.


Lord Rosenheim.

Lord Rosenheim.


Evidence on the site and nature of endotoxin action.


Dr. Jerome L. Reeves on the practice of obstetrics in Carolina Appalachia during the old days.


Digitoxin radioimmunoassay. I. Comparison of three assays for the determination of serum digitoxin levels.


Acupuncture anesthesia in dentistry. A clinical investigation.


Comparison of chlorimipramine and imipramine in ambulatory treatment of depression.


Acute smoke inhalation in children.

Acute smoke inhalation in children.


Duration of viability and the growth and expiration rates of group E streptococci in soil. In irradiated and nonirradiated feedlot and pasture soils inoculated with group E streptococci, the organism was not recovered 17 days postinoculation from either the irradiated or nonirradiated feedlot soils incubated at 37 C, but survived in the irradiated pasture soils for 24 and 31 days postinoculation. The streptococci survived in irradiated and nonirradiated soils incubated at 4 C for 116 days and in one irradiated feedlot soil for 165 days. The population of streptococci did not increase in either irradiated or nonirradiated soil, and the expiration rate was greater in the soils incubated at 37 and 25 C than at 4 C. With the relatively prolonged duration of viability of group E streptococci in soil at 4 C, it is suggested that soil contaminated with exudate from draining abscesses of infected swine could act as a source of infection during the colder season.


Growth of Hansenula holstii on cadavers. Growth of a yeast was observed on prosected cadavers used for demonstration purposes in a medical school. An asporogenous yeast was isolated and identified as an atypical form of Hansenula holstii by analysis of the extracellular polysaccharide. The isolate showed resistance to embalming fluid but was eventually eradicated by addition of picloxidine digluconate to the fluid.


Evaluation of the corneal test as a laboratory method for rabies diagnosis. The corneal test (CT) for rabies diagnosis was evaluated in samples from 313 subjects of different species. Some of the subjects were inoculated experimentally and others were naturally infected. When the CT was compared with immunofluorescence staining and mouse inoculation tests on brains of the same subjects, a sensitivity of 41.7% and a specificity of 100% were found. The authors conclude that a positive CT result would confirm the diagnosis of rabies, but a negative one would not exclude the possibility of disease.


Evaluation of the salmonellae fluoro-kit for fluorescent-antibody staining. An evaluation of the newly developed Clinical Sciences, Inc. Salmonellae Fluoro-Kit, which attempts to standardize the various aspects of the fluorescent-antibody (FA) procedure, was performed with 120 naturally contaminated human food, animal feed, and raw material samples. The Association of Official Analytical Chemists (AOAC) method for the detection of salmonellae was used as the control method. The Fluoro-Kit was found to be simple and conveniento to use. The results of this preliminary study show an industrially acceptable rate of recovery of salmonellae by using the Fluoro-Kit in comparison with the A.O.A.C. method. The Fluoro-Kit shows promise as a rapid, salmonellae FA screening method. Problems originally encountered in the application of the Fluoro-Kit are discussed. According to the manufacturer, strict adherence to the now revised procedures included in the Fluoro-Kit will control these problems.


Micromethod for serogrouping Escherichia coli. A micromethod for serogrouping strains of Escherichia coli is described. The method is accurate, rapid, and economical in terms of time and reagents utilized to perform the test.


Application of the most-probable-number procedure to suspensions of Leptospira autumnalis Akiyami A. Various statistical tests are presented as evidence that the most-probable-number (MPN) procedure is a reliable method for estimating the density of washed-cell suspensions of Leptospira autumnalis Akiyami A.


Simple method for culturing anaerobes.

Simple method for culturing anaerobes. A simple, effective method is needed for growing obligate anaerobes in the clinical laboratory. This report describes a pre-reduced anaerobic bottle that can be taken to the bedside for direct inoculation, provides a flat agar surface for evaluation of number and morphology of colonies, and can be incubated in conventional bacteriological incubators. Each anaerobic culture set consisted of two bottles containing brain heart infusion agar and CO(2). Gentamicin sulfate (50 mug/ml) was added to one of these to inhibit facultative enteric bacilli. Comparison of the anaerobic bottles with an identical aerobic bottle which was also routinely inoculated permitted early identification of anaerobic colonies. Representative species of most anaerobic genera of proven pathogenicity for man have been isolated from this system during 10 months of routine use.


Survivor curves for Leptospira autumnalis Akiyami A based on most-probable-number values. The validity of survivor curves for Leptospira autumnalis Akiyami A based on most-probable-number values is supported by the following observations: (i) linear regression lines fell within most of the 95% confidence intervals; (ii) linear correlation coefficients (r) were consistently high (i.e., near -1); and (iii) statistical tests for goodness of fit usually accepted the linear model. These tests are consistent with an exponential death rate for the test organism in defined solutions. The influence of temperature and pH on survival was demonstrated by showing a statistically significant difference in survivor curve slopes.


Auxotab--a device for identifying enteric bacteria. A multitest system called the Auxotab that uses ten dehydrated reagents on a paper card has been evaluated with 417 known stock cultures of Enterobacteriaceae. In double-blind studies with the Auxotab, 87% of the strains tested were correctly identified. Results of this study indicate that there is a need for modification of the product in regard to ease of handling, time required for use, and accuracy of identification of enteric bacteria.


A partial veneer restoration.

A partial veneer restoration.


Evaluation of the redesigned enterotube--a system for the identification of Enterobacteriaceae. The redesigned Enterotube has been evaluated with 414 unknown Enterobacteriaceae cultures from the stock culture collection of the Center for Disease Control. When the Enterotube was used as recommended by the manufacturer, an average of 96.4% of these cultures were correctly identified. Only two groups (Salmonella and Edwardsiella) were identified with less than 90% accuracy (89.2 and 87.5%, respectively). The Enterotube now provides a convenient, rapid, and accurate test system for the identification of typically reacting enteric bacteria.


The rubber impression for pin restorations.


Cell surface antigenic changes induced in normal adult rat liver cells by carcinogen treatment in vitro. Normal rat liver cell lines treated with the chemical carcinogen N-methyl-N-nitrosourea (MNU) elicited antibody production (detected by membrane immunofluorescence test in vitro) when injected into a highly inbred strain of rats from which the liver cells were originally isolated. In contrast, the control cells which were untreated did not evoke humoral antibodies. Antisera raised against the MNU-treated cells reacted not only with the immunizing cells, but also with 3'-methyl-4-dimethyl aminoazobenzene and 3-methylcholanthrene-treated cells. However, this antiserum failed to react with cells treated with either aflatoxin or N-acetoxy-2-acetyl-aminofluorene. Embryonic antigens were found to be absent from the normal adult liver cell line. Preliminary results indicated that none could be detected on carcinogen-treated cells either.


Penetrating keratoplasty in trachomatous patients.


Human leukaemia: recent tissue culture studies on the nature of myeloid leukaemia.


Autotrichograft sutures in cataract surgery.


Treatment of spina bifida cystica.

Treatment of spina bifida cystica.


Fashions in duodenal ulcer surgery.

Fashions in duodenal ulcer surgery.


Fish cornea for grafting.

Fish cornea for grafting.


Treatment of typhoid.

Treatment of typhoid.


Polypropylene sutures.

Polypropylene sutures.


F. R. Waldron.

F. R. Waldron.


P. C. Mallam.

P. C. Mallam.


C. M. Smith.

C. M. Smith.


F. C. Angior.

F. C. Angior.


E. F. D. Gawne.

E. F. D. Gawne.


D. H. B. Bevan-Jones.

D. H. B. Bevan-Jones.


Colin Hurry.

Colin Hurry.


Results of renal transplantation.

Results of renal transplantation.


Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.


Locally advanced breast cancer.

Locally advanced breast cancer.


M. Donalson.

M. Donalson.


Sir Clement Price Thomas.

Sir Clement Price Thomas.


Non-ionic (NH 3 degrees) ammonia formations in Vibrio species.


Immunopathology of allergic lung disease.


Purpuric dermatosis due to house-dust mite (Dermatophagoides spp.) allergy: a case report.


Pulmonary aspergilloma--clinical immunology.


Talk to New Haven Medical Association, 1903.


Caved-S and Ulcedal for peptic ulcer.

Caved-S and Ulcedal for peptic ulcer.


Nephrotoxicity of chloroquine. A light and electron microscopic study. I. Light microscopic observations.


Bacterial fructolysis in human seminal plasma.


Cellular localization of glucagon by fluorescence microscopy. Reaction of NH 2 -terminal histidine with o-phthaldialdehyde.


The scanning electron microscope: potential usefulness to biologists. A review.


Effect of streptomycin therapy on serum lipid-lipoprotein profiles of rabbits infected with Mycobacterium bovis.


Passive immunization against varicella-zoster infections and other modes of therapy.


Rabies neutralizing antibody: inadequate response to equine antiserum and duck-embryo vaccine.


Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy.


The A, B, C's of mechanical ventilation. 3. Monitoring ventilation and blood gases.


M. Glenn Koenig, M.D., 1931-1972.

M. Glenn Koenig, M.D., 1931-1972.


Body disturbance and sexual elaboration factors in figure drawings of schizophrenic patients.


Diagnosis of conversion hysteria: an interpretation based on Structural analysis.


The meaning of drawing-completion stimuli: new guidelines for projective interpretation.


Inderjit Singh (1909-1972).

Inderjit Singh (1909-1972).


Hepatic disease and pregnancy.

Hepatic disease and pregnancy.


Prostaglandins: perspective in obstetrics and gynecology. Prostaglandins (PGs) are metabolic regulators produced at the cellular level to exert a local action, usually of a modulating type.  Their biological function is analogous to cycle adenosine 3",5' monophosphate (cAMP) (i.e., acting as messengers) rather than to a steroid function, although PGs interact with both cAMP and steroids.  Clinicians need to know the endogenous biosynthesis of PGs, their metabolism, and their detection to use PGs therapeutically with competence.  Apparently, endogenous biosynthesis of PGs is catalyzed by a microsomal enzyme system composed of many different enzyme types.  The required precursors are essential fatty acids, arachidonic acid, and bis-homo-y-linolieic acid in the unesterified form.  Molecular oxygen and other cofactors are also required.  This biosynthesis was worked out in sheep seminal vesicles, but it is now recognized that virtually all tissue types in mammals synthesize PGs.  The metabolic degradation and inactivation of PGEs and PGFs, both derived from the same intermediate, are extremely rapid (Samuelsson et al., 1971, 1972).  The most important first step is oxidation of the 15-hydroxyl group to a carbonyl, which modifies the activities of PGs and allows further degradation and elimination via urine; this series of steps protects the body from these potent agents.  Detection and analysis are best achieved by deuterium-labeled intermediates which are determined by mass spectrometry.  It is important to remember that various tissues have widely varying responses to PGs; for example, PGs have luteolytic action in sheep but do not induce uterine contractions, whereas the opposite seems true in humans.


Anemia complicating pregnancy.

Anemia complicating pregnancy.


Anxiety and rumor.

Anxiety and rumor.


The use of the mini pill in private practice.


Yersiniosis in wildlife and its public health implications.


Liver transplantation.

Liver transplantation.


Host and tick relationships: a review.

Host and tick relationships: a review.


Blood flow into the autotransplanted canine lung after administration of sympathomimetic drugs.


Encapsulation of the Björk-Shiley aortic disc valve prosthesis caused by the lack of anticoagulant treatment.


Viroids.

Viroids.


The metabolic and nutritional consequences of bacterial overgrowth in the small intestine.


Nutritional aspects of chronic pancreatitis.


Intrarenal heterogeneity. The case for two functionally dissimilar populations of nephrons in the mammalian kidney.


Invisible lower cuspid to cuspid retainer.


The role of acid in the pathogenesis of aspirin-induced gastrointestinal erosions and hemorrhage.


Genetic approaches to the syndrome of minimal brain dysfunction.


The effects of intrauterine and postnatal undernutrition on normal brain development.


Detection and differentiation of microfilariae in canine blood.


Interpretation of the oxygen intake test. What is it?


Lutes, glues, cements and adhesives in medicine and dentistry.


The odontological Museum of the Royal College of Surgeons of England.world.


Pulmonary disease after amitriptyline overdosage.


Tetanus.

Tetanus.


Prolonged action of pindolol.

Prolonged action of pindolol.


Nature of hyperacute rejection.

Nature of hyperacute rejection.


H.W. Symons.

H.W. Symons.


Spina bifida splint.

Spina bifida splint.


W.E. Dornan.

W.E. Dornan.


G.L. Hindson.

G.L. Hindson.


T. Chalmers.

T. Chalmers.


Deliberate inhalation of volatile hydrocarbons: a review.


Nutrition in our society.

Nutrition in our society.


Cell differentiation and carcinogenesis: a critical review.


Medicolegal contributions of historical interest. The signs of death, second stage. (B). The period of cadaveric rigidity (rigor mortis) from Legal Medicine, Part I by Charles Meymott Tidy. Published London, 1882.


Carpal tunnel syndrome.

Carpal tunnel syndrome.


Van Helmont's concept of disease--to be or not to be? The influence of Paracelsus.


Chemistry and biology of two proteins, S-100 and 14-3-2, specific to the nervous system.


Owen C. Williams, sculptor.

Owen C. Williams, sculptor.


Air pollution research needs: livestock production systems.


Acupuncture: ancient art, modern enigma.


Steroid arthropathy of the hip.

Steroid arthropathy of the hip.


Biosynthetic arginine decarboxylase from Escherichia coli. Purification and properties.


Biosynthetic arginine decarboxylase from Escherichia coli. Subunit interactions and the role of magnesium ion.


Asparaginase. Stereochemistry of the active center as determined by circular dichroism of substrates.


Synthesis and nucleolytic degradation of uracil-containing deoxyribonucleic acid by Escherichia coli deoxyribonucleic acid polymerase. I.


Amino acid sequence studies with the tryptophan synthetase  chain of Salmonella typhimurium.


Amino acid sequence studies with the tryptophan synthetase  chain of Aerobacter aerogenes.


The relation between cell division rate and  3 HTdR incorporation in organ culture.


Histone mediated changes in morphology and confluent density of cultured cells.


Automatic monitoring of suspension cultures.


Cell separation by velocity sedimentation of postnatal mouse cerebellum.


On primary gastrointestinal lymphoma in Iraq (experience with 47 patients).


Stimulation-mapping of the upper human auditory pathway.


Oral contraceptives: therapeutics versus adverse reactions, with an outlook for the future. II.


Isadore S. Ravdin (1894-1972).

Isadore S. Ravdin (1894-1972).


Structure and function of kinetoplast DNA.


Nicolaus Copernicus as physician (1473-1543).


Sir Reginald Watson-Jones (1902-1972).

Sir Reginald Watson-Jones (1902-1972).


Some aspects of modern battle surgery. The Vietnam experience.


Preliminary investigations into surgeons diagnosing abdominal pain.


Psychosocial problems in surgery.

Psychosocial problems in surgery.


Three deliveries that changed the history of the world.


Stem cell and neutrophilic granulocyte kinetics.


Metabolic approach to the diagnosis of megaloblastic anemias.


Disorders of host defense against infection. Pathophysiologic and diagnostic considerations.


Infectious disease problems in various hematologic disorders.


Bleeding disorders due to abnormal platelet function.


Induction of respiration deficient mutants in Saccharomyces cerevisiae by berenil. I. Berenil, a novel, non-intercalating mutagen.


Induction of respiration deficient mutants in Saccharomyces cerevisiae by berenil. II. Characteristics of the process.


Studies on the metabolic role of peptidyl-tRNA hydrolase. I. Properties of a mutant E. coli with temperature-sensitive peptidyl-tRNA hydrolase.


The E. coli cell surface: Isolation of lambda transducing phages carrying the tolPAB cluster.


A regulatory gene and a structural gene for alaninase in Escherichia coli.


Carcinoma of the colon and rectum.

Carcinoma of the colon and rectum.


A deoxyuridine monophosphate phosphatase detected in mutants of Escherichia coli lacking alkaline phosphatase and 5'-nucleotidase.


Growth of Chlamydomonas in a medium containing mercury.


Structural and functional evidence for a repeated 50S subunit ribosomal protein.


Affinity chromatography of  -galactosidase fragments.


Cancer chemotherapy. 3.

Cancer chemotherapy. 3.


Treatment of acute hallucinogenic drug toxicity: specific pharmacological intervention.


Role of ceruloplasmin (plasma ferroxidase) in hypoferremia associated with chronic inflammation and endotoxin.


Quantitative analysis of cell population in mouse intestinal epithelium using citric acid.


The molecular basis of hereditary clotting disorders.


Plato and Freud. The mind in conflict and the mind in dialogue.


Newer anthelmintic drugs.

Newer anthelmintic drugs.


Recent advances and applications of diffuse X-ray small-angle scattering on biopolymers in dilute solutions.


Effect of bronchodilator aerosols on single-breath ("effective") lung volumes in patients with chronic non-allergic obstructive lung disease.


Pulmonary alveolar proteinosis: a review.


Comparative assessment of the efficiency of three new bronchodilators (salbutamol, terbutaline, Th 1165 a) in the management of patients with chronic obstructive lung disease.


Sjögren's syndrome.

Sjögren's syndrome.


The initial management of skeletal injuries in the dog.


Neurologic emergencies in small animals.


Field evaluation of nutrition intervention programs.


Molasses as an energy source for cattle.


Protein digestion. Nutritional and metabolic considerations.


Some aspects of the history of dietetics.


Some observations on secretory cells of nasopharynx using time-lapse cinemicrography.


Citrus fruits and processed citrus products in human nutrition.


Dynamic electrocardiography and computer analysis.


Chromatic and photographic enhancement of vascular studies.


Viral etiology of human chronic encephalopathy.


Borna virus: a new model for slow virus research.


Skeletal resistance to parathyroid hormone in renal failure. Studies in 105 human subjects.


James Jackson, Jr. (1810-1834): a great student of medicine.


Hypercalcemia in reticulum cell sarcoma without hyperparathyroidism of skeletal metastases.


Constipated lymphocytes.

Constipated lymphocytes.


Full-thickness nonperforating corneal grafts.


Effect of centrifugal forces on the structuredness of cytoplasm in growing yeast cells.


Relationship between changes in the structuredness of cytoplasm and rate constants for the hydrolysis of FDA in Saccharomyces cerevisiae.


Post-irradiation dark recovery of photodamage to DNA induced by furocoumarins.


Influence of energy metabolism on the repair of x-ray damage in living cells. II. Split-dose recovery, liquid-holding reactivation and division delay reversal in stationary populations of yeast.


An antigonadotropin from the ovaries of the insect Rhodnius prolixus Stål.


Analysis of indicator distribution in the determination of cardiac output by thermal dilution.


Choice of detection site for the determination of cardiac output by thermal dilution: the injection-thermistor-catheter.


Cells involved in cell-mediated and transplantation immunity in the rabbit. V. The loss of effector cells following extirpation of the spleen or the appendix, sacculus rotundus, and Peyer's patches.


The effect of splenectomy on the immune responses of rabbits to a soluble protein antigen given parenterally or orally.


Cell transfer studies in cyclophosphamide-induced tolerance.


In vitro immune response of partially purified spleen cells: nutritionally distinct stages in differentiation.


Cytological observations on the cytotoxic interaction between lymphocytes and antibody-coated monolayer cells.


The effect of rabbit anti-mouse brain-associated theta serum on the immunologic responsiveness of AKR mice.


MIDAS: a program for investigator-assisted computer analysis of coronary patient data.


Evaluation of lipid methods available to the hospital laboratory.


Treatment of localized skin lesions with betamethasone 17-valerate and triamcinolone acetonide in alcoholic solution under occlusive dressing. A double blind comparative study.


Refinements in bone grafting of the thumb. Operative and post-operative management.


Diagnostic capabilities of the intravenous glucose tolerance test.


Effects of differential experience on dendritic spine counts in rat cerebral cortex.


Activity of units in the hippocampal circuit of the rat during differential classical conditioning.


Failure of seriatim dorsal hippocampal lesions to spare spatial reversal behavior in rats.


Incidence and magnitude of the "priming effect" in self-stimulating rats.


The incidence and distribution of colicinogenic and colicin-sensitive Escherichia coli in the gastro-intestinal tract of the pig.


Production of staphylococcal  -toxin in a defined medium and identification of a stimulating factor from yeast extract.


Translation of RNA coliphages by amino acid-incorporation systems of the Enterobacteriaceae.


A practical approach to the diagnosis and treatment of intestinal malabsorption.


Intermittent positive expiratory pressure in a case of contused lung.


Carbon source utilization tests as an aid to the classification of non-fermenting gram-negative bacteria.


Computers and cardiovascular medicine.

Computers and cardiovascular medicine.


Delayed major vessel hemorrhage following tracheostomy.


Predicting skin graft survival.

Predicting skin graft survival.


Renal transplantation in Fabry's disease.


Ureteroileostomy and duplicated collecting systems.


Candida albicans cystitis: report of a case with special emphasis on diagnosis and treatment.


The association of urothelial atypism with neoplasia: its importance in treatment and prognosis.


Two-stage reconstruction of scrotum for tropical elephantiasis.


A new method for outpatient culture and sensitivity of urine.


Gram-negative urinary tract isolates in southwestern Ontario.


The middle aortic syndrome: report of a case treated by renal autotransplantation.


Penile gangrene successfully treated by débridement and scrotal skin bridge: case report.


Formation of virus-inhibiting factor or interferon in splenectomized mice.


Application of cell culture in studying antibacterial activity of rifampicin to Shigella and enteropathogenic Escherichia coli.


Immunologic aspects of the nephrotic syndrome.


Passive transfer of Heymann nephritis with serum.


Anti-glomerular basement membrane antibody-induced glomerulonephritis.


Anaerobic infections in chronic prostatitis and chronic urethritis.


A unique feature of gram-negative sepsis. Pneumopyopericardium.


Adult Fanconi syndrome, amyloidosis and marked kappa-light chain proteinuria.


Ampicillin-cloxacillin in purulent meningitis.


Drug use as a way of life.

Drug use as a way of life.


Anesthesia in obstetrics. 1. General.

Anesthesia in obstetrics. 1. General.


Treatment of anaphylaxis.

Treatment of anaphylaxis.


Members of the Experimental Psychology Society.


Repair mechanisms and cell cycle dependent variations in x-ray sensitivity of diploid yeast.


Toxicity of irradiated 1-naphthol.

Toxicity of irradiated 1-naphthol.


Sleeplessness in acute and chronic schizophrenia--response to haloperidol and anti-parkinsonism agents.


Effect of radiosensitizing agents on DNA strand breaks and their rapid repair during irradiation.


Guillotine amputation of the foot followed by skin graft for distal gangrene.


Diabetic angiopathy and neuropathy. A review with special reference to circulation in the extremities, the effect of hypophysectomy on capillary resistance and capillary permeability, functional abnormalities in early diabetes.


Suppurative mastitis in infants.

Suppurative mastitis in infants.


Classic pages in obstetrics and gynecology. Gerald A. Galvin, Howard W. Jones, Jr., and Richard W. Te Linde. Clinical relationship of carcinoma in situ and invasive carcinoma of the cervix. Journal of the American Medical Association, vol. 149, pp. 744-748, 1952.


Demonstration of the relationship of carcinoma in sutu to invasive carcinoma of the cervix.


Cervicovaginal epithelium: its origin and development.


Abdominal hysterectomy: relationship between morbidity and surgical technique.


Crisis and change in America's health system.


A bookshelf on veterinary public health.


APHA in its first century.

APHA in its first century.


Survival of Salmonella Typhimurium in animal manure disposal in a model oxidation ditch.


Studies of behavior change to enhance public health.


Biotransformation of volatile anaesthetics with special emphasis on the role of metabolism in the toxicity of anaesthetics.


Action of gentamicin on penicillin G-induced proteus spheroplasts.


Acute and chronic anaesthetic actions on leukocytes.


The in vitro demonstration of the efficacy of trimethoprim as an antibacterial agent in a comparative bacteriological study of the effects of trimethoprim, sulfamethoxazole and the combination trimethoprim-sulfamethoxazole.


Normalizing low arterial CO 2  tension during mechanical ventilation.


Right upper and middle lobe consolidation.


Effects of hemodialysis and renal transplantation on pulmonary function.


Some prominent developments in childhood nutrition: 1972.


Effect of cytochalasin B on the biphasic release of insulin in perifused rat islets.


Follicular stimulation by chronic treatment with synthetic LH-releasing hormone in hypophysectomized female rats bearing pituitary grafts.


Induction of luteinizing hormone (LH) release and ovulation in rats, hamsters, and rabbits by synthetic luteinizing hormone-releasing factor (LRF).


Effect of oxygen on the developing retinal vessels of the rabbit. 3. Mode of growth of rabbit retinal vessels in tissue culture.


Tropical eosinophilia: bibliography.

Tropical eosinophilia: bibliography.


Comparison of guanadrel and guanethidine.


Are air ions biologically significant? A review of a controversial subject.


A modified plaque test for the detection of cells forming antibody to alloantigens.


Intermittent guanazole therapy in adult acute leukemia.


A micromethod for membrane immunofluorescence.


The Kirby-Bauer technique in clinical medicine and its application to carbenicillin.


Indanyl carbenicillin: chemistry and laboratory studies with a new semisynthetic penicillin.


Renal disease in nail-patella syndrome: clinical and morphologic studies.


Microwave cataracts.

Microwave cataracts.


Crush injuries of the hand and fingers. II.


Mapping the DNA fragments produced by cleavage by lambda DNA with endonuclease RI.


Bladder cystitis following focal infection of group A streptococci.


Brain biochemistry and intrauterine growth.


Influence of food and hepatobiliary disease on the excretion of josamycin.


Observations on the disposition of probenecid in patients receiving allopurinol.


5-Hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines.


The effects of pesticides on wildlife: exposure and residues.


Sunny days among Black people: the diary of an expedition into the Liberian jungle, 1935.


Systemic salmonellosis: a sequela of sideremia.


Influence of anatomic site, donor age and genetics on liver implantation in the mouse.


The bacteriological screening of platelet concentrates stored at 22 C.


The computerization of the orthodontic patient.


Computers in orthodontics.

Computers in orthodontics.


Immunologic competence of alveolar cells. I. The plaque-forming response to particulate and soluble antigens.


Immunologic competence of alveolar cells. II. Modification of the plaque-forming response by inhibitors, tolerance, and chronic stimulation.


Lung tissue shrinkage after freeze substitution for histologic study.


The laxative effect of pure sennosides A and B.


Conservative management of osteoarthritis of the hip.


Treatment of psychomotor epilepsy with stereotaxic amygdalotomy.


Antimitochondrial activity of lampren in Saccharomyces cerevisiae.


Effects of  -diethylaminoethyl-diphenylpropylacetate (SKF 525-A) on biological membranes. II. SKF 525-A-induced effects on the growth and uptake of L-amino acids by Escherichia coli (diploid mutant).


Equations for the prediction of normal values for exchangeable sodium, exchangeable potassium, extracellular fluid volume, and total body water.


Some discoveries on myasthenia gravis: the background.


Treatment of spina bifida cystica.

Treatment of spina bifida cystica.


Sickle-cell anaemia.

Sickle-cell anaemia.


L. P. J. Evans.

L. P. J. Evans.


W. J. Clancy.

W. J. Clancy.


G. H. Collins.

G. H. Collins.


J. Reynolds.

J. Reynolds.


Medullo-cervical dislocation deformity (Chiari II deformity) related to neurospinal dysraphism (meningomyelocele).


Freeze-drying of live oral streptomycin-dependent mutant Shigella vaccines: survival of streptomycin-dependent Shigella flexneri 2a after freeze-drying.


A comparative double-blind evaluation of iprindole and imipramine in the treatment of depressive states.


Evaluation of coliform tests for chlorinated secondary effluents.


Tracheal aspiration and fiber optic bronchoscopy.


In memoriam William C. Thomas Sr., M.D.

In memoriam William C. Thomas Sr., M.D.


Florida renal disease program.

Florida renal disease program.


New scalar computer EKG program for on-line central EKG processing.


Incorporation of ( 3 H)glucosamine to the surface component of testicular cultures and the differential response of steroidogenic and fibroblastic cells in vitro to cytochalasin B.


In memoriam: Paul F. Kruse, Jr., 1921-1973.


In vitro culture of cells and tissues from the mosquito, Anopheles quadrimaculatus Say.


A method for the short-term in vitro cultivation of the chick embryo on liquid media.


The distribution, half-life, and excretion of tritiated luteinizing hormone-releasing hormone (LH-RH) in rats.


The mechanisms of venous thrombosis. Anticoagulants, aspirin, and heparin.


The thirteen-year-old Lady Jane Grey describes her love of learning to Roger Ascham.


Normal granulocyte infusion therapy for aspergillosis in chronic granulomatous disease.


Gonadotropins during childhood and adolescence: a review.


Nitroblue tetrazolium dye reduction by neutrophils from patients with streptococcal pharyngitis.


A critical evaluation of urethral obstruction in female children.


Fables for the instruction of youth published in Boston in 1818. Excerpt 8: Wolf and the Lamb.


Additional references on the tension-fatigue syndrome.


Removal of coins from the esophagus: nothing new under the sun.


Ideal radiographic projection for renal transplant angiograms.


Gram-negative pneumonia.

Gram-negative pneumonia.


Massive pulmonary gangrene.

Massive pulmonary gangrene.


Stamps in radiology (Karol Kaczkowski).

Stamps in radiology (Karol Kaczkowski).


Endocranial venous collateral flow in unilateral innominate vein occlusion.


A simple technique for photographic image enhancement of subtraction films.


In memoriam. Willy E. Baensch, M.D. 1893-1972.


In memoriam. Frank A, Riebel, M.D.

In memoriam. Frank A, Riebel, M.D.


In memoriam. Joel Allen, M.D., 1908-1972.


In memoriam. Roy D. Duckworth, M.D., 1890-1972.


Failure of endothelial repopulation to explain prolonged renal allograft survival.


Role of soluble cytotoxins in cell-mediated immunity.


Basis of impaired graft rejection of aging NZB-W mice.


Graft immunogenicity as a function of donor age in the rat.


Extension of skin homograft survival by prevention of graft-host skin contact.


Evidence for multigenic control of immune response to theta-AKR antigen in mice.


The platelet in the obliterate vascular rejection phenomenon.


Chemical carcinogenesis: what is it? (Hypothesis on the molecular--cellular mechanism of the transformation of cells).


Selection of cadaver kidney donors with HL-A phenotypes identical to those of potential recipients.


A collaborative scheme for tissue typing and matching in renal transplantation. VI. Clinical relevance of HL-A matching in 349 cadaver renal transplants.


Effect of blood transfusions on subsequent kidney transplants.


The role of "private" and "public" H-2 antigens in skin graft rejection.


Transplantation analysis of the H-2 system.


Serological cross-reaction between H-2D and H-2K region antigens.


An association between H-2 and the expressivity of H-Y in murine skin grafts.


The new alleles of the H-3 locus.

The new alleles of the H-3 locus.


Regulatory role of the cyclic nucleotides in alloimmune lymphocyte mediated cytotoxicity. Effect of imidazole.


The isolation and characterization of soluble murine H-2 alloantigens.


Cross-reactivity between HL-A and H-2 antigens. II. Allogeneic sensitization by xenogeneic soluble lymphocyte antigens (HL-A).


A heterophile system in human renal transplantation. 3. The HT-A specificities.


White graft reaction after streptococcal and staphylococcal infection in man.


Induction of sensitivity to kidney antigen(s) by streptococcal membranes.


Inhibition of anti-HL-A alloantisera by glycoproteins, polysaccharides, and lipopolysaccharides from diverse sources.


Cyclophosphamide for clinical renal and hepatic transplantation.


Further studies on the in vitro assay of immunosuppressive potency of antilymphocyte serum by the mixed agglutination technique.


Mechanism of permanent survival of canine renal allografts following a limited course of ALS treatment.


High incidence of fungus infections in renal transplantation patients treated with antilymphocyte and conventional immunosuppression.


Experiments with donor enhancement.

Experiments with donor enhancement.


Evaluation of organ specificity in renal allograft enhancement with F(ab') 2  fragments.


Blocking antibodies eluted from human placenta.


Clinical transplantation--an overview.

Clinical transplantation--an overview.


Specific immunosuppression of antibody responses by an antiserum against a T-cell factor.


The immunologic status of rats with long-surviving (enhanced) kidney allografts.


The weaker the histoincompatibility, the greater the effectiveness of specific immunoblocking antibodies: a new immunogenetic rule of transplantation.


Antibody turnover by enhanced rat kidneys.


Homograft survival and serum-blocking factors.


Reduction of immunogenicity of human cadaver renal allografts by donor pretreatment.


Enhanced survival of canine renal allografts of ALS- treated dogs given bone marrow.


Passive antibody delays development of cell-mediated immunity in rats receiving renal allografts.


Mechanisms and kinetics of cyclophosphamide-induced specific tolerance to skin allografts in mice.


Mechanism of augmented graft survival in mice after ALS and bone marrow infusion.


Comparative survival of skin grafts from several donor species on congenitally athymic mice.


Differential survival of heart and skin allografts in inbred rats.


Destruction of rat skin grafts by humoral antibody.


Heart transplantation in congenic strains of mice.


Dynamics of receptor and antigen interaction at the lymphocyte.


Vascular changes in experimental cardiac allografts.


The diagnosis of canine orthotopic cardiac allograft rejection by transvenous endomyocardial biopsy.


Prolonged survival of vascularized organ allografts in unimmunosuppressed pigs.


The immunologic diagnosis of orthotopic cardiac allograft rejection in dogs.


Influence of DL-A matching, ALS, and 24-hour preservation on isolated pancreas allograft survival.


Homotransplantation of extremities in tolerant dogs observed up to seven years.


Recognition and treatment of rejection in experimental and human lung allografts.


Transplantation for diabetic glomerulosclerosis.


Eight- to ten-year follow-up in early cases of renal homotransplantation.


Presensitization detected by sensitive crossmatch tests.


Endothelial changes associated with hyperacute, acute, and chronic renal allograft rejection in man.


Advances in human heart transplantation.


Metabolic effects of hepatic replacement in Wilson's disease.


Parameters of allogeneic unresponsiveness in canine radiation chimerae, with particular reference to the possible existence of three closely linked genetic systems relevant to bone marrow transplantation.


In vitro modification of donor bone marrow used to produce enhanced graft survival in antilymphocyte serum (ALS)-treated mice.


Electrophoretic fractionation of mouse T and B lymphocytes. Efficiency of the method and purity of separated cells.


Antidonor immunologic reactions of long-standing radiation chimeras.


Procurement of runt disease of maternal origin.


Lymphocyte ecology and immunologic tolerance.


Allogeneic marrow grafting for acute lymphoblastic leukemia: leukemic relapse.


Marrow grafting in identical twins with hematologic malignancies.


Immunogenicity and enhancement of normal and tumor tissue in the mouse.


Workshop on bone marrow transplantation.


Virus-induced obstruction of the ureteric and cystic duct in allograft recipients.


Sir William Thomson, physician.

Sir William Thomson, physician.


Forty years on.

Forty years on.


Renal transplantation between monozygotic twins discordant for unilateral renal agenesis.


The malabsorption syndromes. Some clinical problems.


Aerosolized dexamethasone isonicotinate in the treatment of bronchial asthma. A double blind study.


Symptomatic relief with flupentixol (Fluanxol) of the anxious-algetic-depressive syndrome complex in neurotic states. A double-blind, placebo-controlled study.


Length of treatment with anxiolytic sedatives and response to their sudden withdrawal.


Clinical and work performance variables in phenothiazine therapy of schizophrenia.


Comparative trial of imipramine N-oxide and imipramine in the treatment of out-patients with depressive syndromes.


Infectious risk factors in the immunosuppressed host.


Immunopathology of the nephrotic syndrome associated with renal vein thrombosis. Report of two cases and brief review of the literature.


Ehlers-Danlos syndrome with megaduodenum and malabsorption syndrome secondary to bacterial overgrowth. A report of the first case.


Vitamin E and free radical peroxidation of lipids.


The effect of vitamin E on the immune response of hypoxic and normal chickens.


The role of polyunsaturated fatty acids in determining vitamin E requirement.


Vitamin E and the biological antioxidant theory.


Vitamin E and metabolic regulation.

Vitamin E and metabolic regulation.


Neuro-ophthalmology.

Neuro-ophthalmology.


Increased homograft survival. Internal thoracic duct-esophageal shunt.


Homograft reconstruction of the nasal septum.


Single-stage repair of bilateral cleft lip.


The forehead island flap in oral cavity reconstruction.


Musculocutaneous flap technique in blepharoplasty.


Coarctation of the abdominal aorta.

Coarctation of the abdominal aorta.


Intravascular coagulation and glycerin hemoglobinuric acute renal failure.


Effect of relative centrifugal force on the apparent size of DNA from Escherichia coli cells.


Biosynthesis of cerebral phenolic amines. II. In vivo regional formation of p-tyramine and octopamine from tyrosine and dopamine.


Enzymatic and physical studies on the triplex dTn.dAn.rUn.


An experimental approach to the study of drugs in invertebrate systems. I. Mass feeding of Rhodnius prolixus Stål (Hemiptera, Reduviidae).


Defective insulin secretory response to glucose in the New Zealand obese mouse. Improvement with restricted diet.


Evaluation of the role of exogenous insulin on phasic insulin secretion.


The millenary steps of ocular surgery.

The millenary steps of ocular surgery.


Anticipation of analgesia. A placebo effect.


Arthritis and the working man: hope through research.


Effect of insulin on hypophyseal prolactin & hypothalamic prolactin-inhibiting factor in rat.


Biochemical changes in biotin deficient Aspergillus nidulans.


Virology and epidemiology of rubella virus.


Clinical manifestations of the congenital rubella syndrome.


Immunologic factors in liver disease.

Immunologic factors in liver disease.


Effect of surface active agents and semisolid agar media on the growth of Mycobacterium leprae.


Studies of the strain of Salmonella typhi responsible for the Aberdeen typhoid outbreak.


The Walker program for advanced education in oral surgery.


Panoramic x-ray equipment. Council on Dental Materials and Devices.


Living in the past.

Living in the past.


L. Hendershot resigns as editor of ADA.

L. Hendershot resigns as editor of ADA.


Congenital kyphosis. Its natural history and treatment as observed in a study of one hundred and thirty patients.


Triple osteotomy of the innominate bone.


Treatment of displaced subcapital and transcervical fractures of the femoral neck by muscle-pedicle-bone graft and internal fixation. A preliminary report on one hundred and fifty cases.


Treatment of chronic osteomyelitis by radical excision of bone and secondary skin-grafting.


Post-traumatic hip redislocation.

Post-traumatic hip redislocation.


Toxoplasmosis in Taiwan. 3. Evaluation of a modified technique for detection of cysts of Toxoplasma gondii in swine brains.


Identification of toruloma of the brain (Elliott C. Cutler).


The stromacentre of plastids of Kalanchoë pinnata Persoon.


Changing patterns in cervical cytology among oral and non-oral contraceptive users. 9634 patients (21-39 years, with at least 1 normal pregnancy) with no previous experience with oral contraceptives or IUDs, seen at clinics in Rio Piedras, Caguas, and Ponce, Puerto Rico from July 1961 to October 1969 to study their changing  patterns in cervical cytology were divided randomly into 2 groups, of which 4846 were given oral contraceptive, Enovid, and 4788 provided with a vaginal contraceptive excluding IUDs, and followed for a period of 6 months-8 years.  Separate Pap smears were obtained at admittance to the study by an endocervical aspiration with the pipette and cervical sample with Ayre spatula scraped over the cervico-columnar junction.  The cervix was diagrammed showing any erosion.  Schiller tests were done.  Possible presence of Trichomonas vaginalis was treated.  Repeat smears were done at 3-month intervals.  2129 oral patients and 2249 nonoral patients experienced either regression or progression in cytological patterns throughout the 8 years of observation.  The analysis is divided into 3 groups, irrespective of the time at which they were observed.  Of the 2129 oral patients showing a first change, 55.5% progressed to a higher Pap class, 44.5% regressed to a lower Pap class.  In the nonoral group, 55.2% progressed and 44.4% regressed.  1255 patients had a second change: in the oral group, 37.5% progressed, 62.5% regressed.  In the nonoral group, 36.7% progressed, 63.3% regressed out of 1258 patients.  690 oral patients showed a third change: 46.1% progressed and 53.9% regressed.  Of the 718 nonoral patients 47.1% progressed and 52.9% regressed.  There was no significant difference in the pattern of progression and regression between oral and nonoral groups.  Oral contraceptives do not aggravate the conditions which lead to development of premalignant lesions in the uterine cervix.


Passage of cytoplasmic lipid into interphase nuclei in preneoplastic rat liver.


Regulation of plasma aldosterone concentration in anephric man and renal transplant recipients.


Fenfluramine--another appetite suppressant.


The Samuel Proger Health Services Building.


Donald Munro, M.D., 1889-1973.

Donald Munro, M.D., 1889-1973.


Pollution of beaches: reply to Regnier and Park.


Dr. Stephen R. Pelc.

Dr. Stephen R. Pelc.


Psychotherapy in Old Vienna and New York: cultural comparisons.


Jule Nydes: psychologist, psychoanalyst, human being.


Basic concepts of radiocardiography.

Basic concepts of radiocardiography.


Coronary blood flow assessment with xenon and rubidium.


Detection of intracardiac shunts with radionuclide imaging.


Radionuclide determination of myocardial blood flow.


Potassium and the anaesthetist. A review.


The fourteenth John Snow Memorial Lecture.


The first three days in the history of surgical anaesthesia in England.


Obituary. Ronald Jarman, DSC, FRCS, FFARCS, FFARSCI (Hon).


Anaesthetic literature.

Anaesthetic literature.


Flora in newborn infants: annual variation in prevalence of Staphylococcus aureus, Escherichia coli, and streptococci.


Tympanoplasty.

Tympanoplasty.


Haemodynamic effects of sodium nitroprusside during nitrous oxide-halothane anaesthesia.


Bacteriolytic and bactericidal activity in monocytic and myelomonocytic leukemia with hyperlysozymemia.


Further experience with tongue flap in cleft palate repair.


Spare the rod: a survey of the battered-child syndrome.


Nonsense motility mutants in Salmonella typhimurium. Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at least one further new group; the hypothesis of a fla gene which specifies only an RNA structural component of a flagellum-synthesizing basal apparatus is disproven for the corresponding genes. Hfr and transductional crosses confirmed gene assignments from complementation and indicated that flaM and another new fla locus map near H1. A small minority of motile bacteria were detectable in many of the amber fla mutants. In groups A and F some pairs of amber fla mutants complemented each other, and perhaps each of these groups corresponds to more than one structural gene. The suppressed derivatives of a mutant with an amber mutation in H1 made flagella morphologically and serologically indistinguishable from wild-type flagella. A slow-spreading but flagellate mutant showed mainly non-translational motility in broth, and in a viscous medium the bacteria reversed very frequently; its amber mutation, probably near H1, is inferred to cause a defect in chemotaxis, so that the bacteria give the avoidance reaction continuously.


A radioisotope method of measuring intragastric volumes using the Volémetron. A new method of measuring intragastric volumes using the Volémetron and (125)RIHSA is reported. The method has been used to measure serially the change in intragastric volumes following milk and water feeds in a group of six dogs.


Acrodermatitis enteropathica.

Acrodermatitis enteropathica.


Ultrastructural organization of chloroplast thylakoids of the green alga Oocystis marssonii. Intact cells of "Oocystis marssonii" were thin sectioned and freeze-etched, using conventional and double-recovery techniques. Thylakoids extend the length of the single chloroplast and occur in stacks of three to five. The peripheral thylakoids in a stack often alternate between adjacent stacks. Interpretation of double-recovery results suggests that membranes in unstacked regions are asymmetrical, with one face smooth and the matching face covered with closely packed 85-90 A diameter particles. Adjacent membranes in stacked regions evidently share 170 A diameter particles, and either membrane in a stacked region may fracture. The two fracture planes thus made possible may expose nearly entire 170 A particles or only the upper portion of such particles, creating in the latter case images of 125-135 A diameter particles. Fracture planes in all cases appear to occur through the interior of the membrane, in the plane between the hydrophobic ends of the lipid bilayer proposed in numerous membrane models.


Unusual striated thick filaments in Limulus skeletal muscle.


RNA synthesis by exogenous RNA polymerase on cytological preparations of chromosomes. Cytological preparations of Drosophila polytene chromosomes serve as templates for RNA synthesis carried out by exogenous RNA polymerase (Escherichia coli). Incorporation of labeled ribonucleoside triphosphates into RNA may be observed directly by autoradiography. Because of the effects of rifampicin, actinomycin D, ribonuclease, high salt, and the requirement for all four nucleoside triphosphates, we conclude that the labeling observed over chromosomes is due to DNA-dependent RNA polymerase activity. Using this method, one can observe RNA synthesis in vitro on specific chromosome regions due to the activity of exogenous RNA polymerase. We find that much of the RNA synthesis in this system occurs on DNA sequences which appear to be in a nondenatured state.


The midwife--in Simpson's time and ours.


The effect of intra-amniotic oestriol sulphate on abortion induced by hypertonic saline.


A pituitary function test with synthetic LH-releasing hormone.


Intra-amniotic prostaglandin E 2  and F 2   for induction of abortion: a dose response study.


Scanning electron microscopic studies of Paranaplasma sp. in erythrocytes of a cow.


Intestinal parasites.

Intestinal parasites.


B lymphocytes in lepromatous leprosy.

B lymphocytes in lepromatous leprosy.


Skin infection due to Salmonella enteritidis.


Hyperuricemia in leukemia and lymphoma. I. Clinical findings and pathophysiology.


Experimental xenogeneic kidney transplantation in closely related systems. E vivo hemoperfusion of kidney in the system cat (donor) to dog (recipient).


The intracellular organisation of cholesterol biosynthesis. A review.


The carcinoembryonic antigens of human tumours.


Bacterial resistance to antimicrobial agents.


1972 Nobel Prize for Medicine and Physiology.


Typical and reticular degenerative retinoschisis.


Senile macular degeneration. Clinicopathologic correlations of a case in the predisciform stage.


Recurrence of hereditary corneal dystrophy following keratoplasty.


Micromanipulator arc system for intravitreal surgery.


An ultrasensitive radioassay for hexokinase.


William Thomas Green Morton (1819-1868).


The effect of incremental PEEP on PaO 2 in patients with respiratory failure.


Frederick Hall Van Bergen, M.D.

Frederick Hall Van Bergen, M.D.


Preoperative intermittent positive pressure breathing therapy in patients with chronic obstructive lung disease: effect on postoperative pulmonary complications.


Controlled comparison of lorazepam and pentobarbital as hypnotics for presurgical patients.


American surgery's noblest experiment.

American surgery's noblest experiment.


Management of major vascular injuries in the base of the neck. An 11-year experience with 146 cases.


Clinical experience with pancreaticoduodenal transplantation.


Antithymocyte globulin in renal transplant krecipients. A clinical trial.


Academic surgery program, P.C. One solution to the problem of providing a suitable resident service.


Mumps virus and BCG vaccine in metastatic melanoma.


Suprapubic bladder drainage in general surgery.


New techniques in objective arterial evaluation.


Investigations in mastitis problem herds. I. Bacteriological examination.


Principles of anaesthesia.

Principles of anaesthesia.


Ketosis in pregnant sheep and lactating cows. A review.


The Royal Prefix.

The Royal Prefix.


The role of diagnostic radiology including lymphography in malignant lymphomas.


The physical measurement of bone mineral in humans. 1. Measurement by diagnostic radiography.


Characterization of a phosphorylated pentasaccharide isolated from Hansenula holstii NRRL Y-2448 phosphomannan.


An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate.


Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate.


All-or-nothing character of DNA degradation in bacteria after ionizing radiation. The response of single cells of Escherichia coli B(s-11) and 15JG151 to radiation-induced DNA degradation has been observed by autoradiography. For both cells it is concluded that the event which causes DNA degradation is of an all-or-nothing character. The unit which suffers degradation is not the whole cell, but each cell has between two and four such units. The results suggest that there is some resynthesis of degraded DNA. Evidence that this occurs is shown by examining the degradation of mass cultures of 15TAU/t3 and t7 below and above the permissive temperature for DNA synthesis. The results on the all-or-nothing character are in agreement with previous studies made by completely different techniques.


Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog.


A clinical trial of three root canal medicaments.


Fissure sealants. Results obtained with two different bis-GMA type sealants after one year.


Acupuncture for therapy and analgesia. A possible application in dental surgery.


Early and modern dentistry in Australia.


Effects of oxygen upon freeze-dried and freeze-thawed bacteria: viability and free radical studies.


Soil bacteriostasis limitation in growth of soil and rhizosphere bacteria.


Fluorescent antibody as a method for the detection of fecal pollution: Escherichia coli as indicator organisms.


Scanning electron microscopy of morphological alterations in Proteus mirabilis induced by cephalosporins and semisynthetic penicillins.


A study of the serotyping of Proteus rettgeri.


Studies of the metabolism of separated bone cells. I. Techniques of separation and identification.


Effect of supplementary aeration on the growth of Thiobacillus thiooxidans in shaken cultures.


Fate of the plasma membrane of Saccharomyces cerevisiae during cell rupture.


Intrarenal blood flow in congestive heart failure.


Assessment of ventricular function after acute myocardial infarction by plasma volume expansion.


Theory and practice of minidose heparin in surgical patients. A status report.


Left ventricular function, metabolism, and blood flow in chronic cor pulmonale.


Pediatric radiocardioangiography. Shunt diagnosis.


Wolff-Parkinson-White Syndrome. A review.


Digitalis intoxication in patients with atrial fibrillation.


The in vitro sensitivity of Bibrio Cholerae strains to sulfamethopyrazine and aminosidine and data on the transfer of drug resistance from E. coli to some cholera agent strains.


Identification of intrarenal fibrin deposition. The site and extent of intrarenal fibrin deposition has been examined by routine histological staining, immunofluorescence, and electron microscopy in 109 patients with a wide variety of renal diseases. The findings have been correlated with the amount of urinary fibrin/fibrinogen degradation product (FDP) excretion as measured by the tanned red cell haemagglutination inhibition immunoassay. The results show that routine histological stains (Martius Scarlet Blue and Picro Mallory) are unreliable, particularly where there is mesangial accumulation of material or where the amount of fibrin deposited is small and confined to a subendothelial position. Similarly the electron microscope may overassess the degree of fibrin deposition, particularly if this is associated with the deposition of immunoglobulins and complement. There is a close relationship between the site and extent of fibrin, as detected by immunofluorescence, and the maximal urinary FDP excretion.


A replica technique for paraffin sections for transmission electron microscopy.


Intravascular coagulation and E. coli septicaemia. Eight patients with E. coli septicaemia had oliguric renal failure which was associated with haematological evidence of intravascular coagulation. Five of these patients also had the characteristic blood picture of microangiopathic haemolytic anaemia. In an attempt to prevent further deposition of fibrin, intravenous heparin was administered to six patients, three of whom recovered fully and three died. The diagnosis of intravascular coagulation was subsequently confirmed by histological examination of necropsy material and it is suggested that some of the complications of E. coli septicaemia may be attributable to disseminated intravascular coagulation.


An in-line milk sampler for determining the numbers of bacteria derived from teat surfaces and udder infections of cows milked in recorder machines.


Studies on the replication of bacteriophage T5.


Infectious drug resistance in Thailand. V. Drug-resistant Escherichia coli in foods and water from central Thailand.


The incidence of transient bacteremia following pulpotomies on primary teeth.


Central neurilemoma of the mandible: report of case and review of the literature.


Squamous cell carcinoma arising in a dentigerous cyst.


Time as a factor in predicting the vitality of traumatized teeth.


Motivation and coping behavior in adaptation to contact lenses.


The Road Test and the unconscious flight orientation (UFO).


Directory of members of the Society for Personality Assessment as of April 1, 1973.


Health maintenance.

Health maintenance.


Biological effects of formocresol.

Biological effects of formocresol.


Tissue reactions to improved zinc oxide-eugenol cements.


Inflation is an attitude.

Inflation is an attitude.


Pulpectomy and root canal filling in a primary molar: report of a case.


Morse Kochtitzky, M.D. 85th President--Tennessee Medical Association.


Balloon occlusion of a persistent left superior vena cava in the preoperative evaluation of systemic venous return.


Left  ventricular bypass for ventricular failure. Technical and hemodynamic considerations.


Formocresol pulpotomy in teeth of dogs with induced pulpal and periapical pathosis.


Diagnostic applications of ultrasound in obstetrics: a review.


Treatment open-end primary tooth: report of case.


In vivo synthesis of sulfur containing amino acids in Candida albicans.


Fetal origin of x-cells in human placental septa and basal plate.


Significance of hypokalaemia due to diuretics.


Intracranial reinforcement in pigeons: an analysis using concurrent schedules.


Hypothalamic glucoreceptors--the influence of thioglucose implants in the ventromedial and lateral hypothalamic areas of normal and diabetic rats.


Effects of intraventricular (3 ventricle) injections of 2-deoxy-D-glucose, glucose and xylose on feeding behavior of sheep.


A spring loaded carrier for transection of fornix and other large fiber bundles.