Clinical pharmacology.

Clinical pharmacology.


Rapid bacterial screening in the treatment of civilian wounds.


Aerosol propellants are toxic to the heart.


Aborted crib death?

Aborted crib death?


Bear meat hazards.

Bear meat hazards.


Hahnemann yesterday--its spirit lives.

Hahnemann yesterday--its spirit lives.


Regional approach valuable in chronic hemodialysis programs.


Management of electrical burns of the upper extremity.


Lower eyelid reconstruction.

Lower eyelid reconstruction.


Cross-leg flaps in children.

Cross-leg flaps in children.


Investigation of bone changes in composite flaps after transfer to the head and neck region.


The Duhamel procedure for treatment of the Pierre Robin syndrome.


Studies in rats of survival of composite homotransplants of skin and subcutaneous tissue, with microvascular anastomoses.


Harold M. Trusler, M.D. 1897-1972.

Harold M. Trusler, M.D. 1897-1972.


John Kosa: in memoriam.

John Kosa: in memoriam.


Health, history and the social sciences.


A mutant of bacteriophage øX174 which infects E. coli K12 strains. I. Isolation and partial characterization of øXtB.


Mapping of host range mutants of bacteriophage phiX174.


A mutant of bacteriophage øX174 which infects E. coli K12 strains. II. Replication of øXtB in tsDNA strains.


Role of dna genes of Escherichia coli in M13 phage replication.


Transfection by half molecules and inverted molecules of lambda DNA: requirement for exo and  -promoted recombination.


Infection of tobacco mesophyll protoplasts by cucumber mosaic virus.


Mechanism of endotoxin-type interferon production in mice.


Degradation of T4 DNA synthesized in the absence of phage ligase.


Evidence for the utilization of host tRNA(m 5 U)methylase to modify tRNA coded by phage T4.


Psychoanalysis in Hitler Germany: 1933-1949.


LeRoi Jones' Dutchman: inter-racial ritual of sexual violence.


Henry James' The Ambassadors: the primal scene revisited.


James Barrie's "M'Connachie"--his "writing half".


Alexander B, Gutman, 1902-1973.

Alexander B, Gutman, 1902-1973.


Hypercalcemia and an elevated alkaline phosphatase level.


A case of lymphoproliferative disease presenting as juvenile rheumatoid arthritis. Diagnosis by synovial fluid examination.


Mycobacterium avium infections in man.

Mycobacterium avium infections in man.


Biological ion exchanger resins.

Biological ion exchanger resins.


Energy requirements of bacterial ion exchange.


Current status of the water-structure problem; application to proteins.


Pressure effects on the association of the   and   2  subunits of tryptophan synthetase from Escherichia coli and Salmonella typhimurium.


Interaction of rabbit reticulocyte elongation factor 1 with guanosine-triphosphate and aminoacyl-transfer ribonucleic acid.


Characterization of the cardiolipin synthetase activity of Escherichia coli envelopes.


Half molecules of serine-specific transfer ribonucleic acids from yeast.


Effects of posttrial hippocampal stimulation on memory storage and EEG activity.


The hippocampus and retrograde amnesia: localization of some positive and negative memory disruptive sites.


The enzymatic acetylation of ribosomal bound protein L 12 .


Do rats terminate hypothalamic stimulation only in order to turn it on again?


The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast.


Rostral medial forebrain bundle lesions produce decrements in masculine, but not feminine, sexual behavior in spayed female rats.


Obtention of antisera against a hypothalamic decapeptide (luteinizing hormone-follicle stimulating hormone releasing hormone) which stimulated the release of pituitary gonadotropins and development of its radioimmunoassay.


Two early artificial ventilators.

Two early artificial ventilators.


Postoperative pulmonary complications using dry and humidified anaesthetic gases.


Effect of lens extraction in pseudoexfoliation of the lens capsule.


Neural activity with cardiac periodicity in medulla oblongata of cat.


Ocular toxoplasmosis.

Ocular toxoplasmosis.


Production of corneal ulcer by opportunistic and saprophytic fungi. 1. The effect of pretreatment of fungi with steroid.


Repair of blepharoptosis with a modification of the Fasanella-Servat operation.


A study of cells in human corneal grafts. Growth potential in vitro, cellular morphology, and fate of donor cells.


The dry socket--a new lubricant (safflower oil).


A comparison of acetylcholine and carbachol following cataract extraction.


Psychiatry and ideology.

Psychiatry and ideology.


Suicide prevention. Review and evaluation.


Anticipatory heart rate deceleration and reaction time in children with and without referral for learning disability.


Artificial pacemakers: indications and management.


Types of pacemakers and their complications.


What ECG computer program to choose for clinical application. The need for consumer protection.


Orthodontic prognosis by computer may provide instant experience.


Natural history of cardiac arrhythmias and their prevention with quinidine in patients with acute coronary insufficiency.


The integration of autonomic system reactions: a discussion of autonomic reflexes, their control and their association with somatic reactions.


Physiology and pharmacology of female reproduction under the aspect of fertility control.


Intermittent pharmacotherapy in chronic schizophrenia.


The effect of antilymphocytic antibody on the humoral immune response in different strains of mice. II. The response to sheep erythrocytes.


Studies on the control of antibody synthesis. 3. Changes in heterogeneity of antibody affinity during the course of the immune response.


The influence of thymectomy on the development of erythrocyte-specific antinuclear factors in obese strain (OS) and normal white leghorn chickens.


The relative distribution of IgM and IgA cells in intestinal mucosa and lymphoid tissues of the young unweaned pig and their significance in ontogenesis of secretory immunity.


The immune response in steroid deficient mice.


Myocardial function and anesthesia.

Myocardial function and anesthesia.


Thirty-five years' experience with controlled ventilation in thoracic surgery.


Anesthesia during human lung transplantation and early postoperative respiratory treatment.


Members of the Colorado Dental Association.


The acid etched restoration for fractured anterior teeth.


Influence of ergot alkaloids on pituitary prolactin and prolactin-dependent processes.


N-trisubstituted methylimidazoles as antifungal agents.


Isolation and in vitro antifungal activity of 6,6'-dihydroxythiobinupharidine.


Relationship of physicochemical properties of isometric trifluoromethylphenols with their bactericidal effect on Escherichia coli.


Motivational determinants of family planning clinic attendance.


Effect of macarbomycin on transfer of R factor among strains of Escherichia coli in vitro.


An adenovirus isolated from kidney cell culture of apparently normal piglet.


Effect of macarbomycin on transfer of R factor among Escherichia coli strains in gnotobiotic pigs.


Bacterial identification by microcalorimetry.


Mode of action of some oxidized sugar derivatives of adenine on platelet aggregation.


Influence of lithium on aggregation, release-reaction and function of human platelets.


Smooth muscle antigens in platelets: immunofluorescent detection using human anti-smooth muscle serum.


"In vitro" and "in vivo" experiences with VK 774, a new platelet function inhibitor.


Carotenoids anno 1972.

Carotenoids anno 1972.


Seventy-five years of research and education in psychiatry. Welcoming remarks.


Seventy-five years of research and education in psychiatry. Opening address.


A magnificent human achievement.

A magnificent human achievement.


Perspectives on the genetics of schizophrenia: a re-evaluation of Kallmann's contribution--its influence and current relevance.


The development of psychology at the Psychiatric Institute: an historical survey.


Achievement motivation and perception of the body boundary.


An aggression machine. II. Interindividual differences in the aggressive defence responses aroused by varying stimulus conditions.


The history of strychnine in the nineteenth-century materia medica.


The mysterious disappearance of the skeleton of Charles J. Guiteau.


Concepts of epilepsy in seventeenth-century England.


Presentation of Jane M. Openheimer, Ph.D. for Honorary Fellowship.


Memoir of M. Royden C. Astley, M.D. 1911-72.


Memoir of William J. Hitschler, M.D. 1904-72.


Memoir of Laurence Bender Rentschler, M.D. 1910-72.


Memoir of Merle M. Miller, M.D. 1903-72.


Officers, committees, sections, administrative staff of the College 1973.


Memoir of Edward Arman Schumann, M.D. 1879-1970.


Family doll play and female identity in pre-adolescent males.


Childhood urolithiasis in Britain.

Childhood urolithiasis in Britain.


Comparative trial of 2 weeks and 8 weeks cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood.


Study of antipyretic therapy in current use.


Photofiberoptic bronchoscopic findings during lung transplant rejection.


Comparative efficacy of nalidixic acid and ampicillin for severe shigellosis.


Lung allotransplantation in dogs with pulmonary hypertension.


Histopathologic changes in the allografted canine pancreas.


Task dependent recovery after early brain damage.


Disruption of the interhemispheric transfer of active avoidance learnt during unilateral cortical spreading depression.


Inhibition of chemically elicited feeding and drinking by autonomic blocking agents.


Cyclical wheel-running behavior in pregnant rats.


Interaction of Escherichia coli carbamyl phosphate synthetase with glutamine.


Specificity of mitochondrial and cytoplasmic ribosomes and elongation factors from Xenopus laevis.


The relationship between mismatched base pairs and the thermal stability of DNA duplexes. I. Effects of depurination and chain scission.


Alkali deamination of cytosine residues in DNA.


The relationship between mismatched base pairs and the thermal stability of DNA duplexes. II. Effects of deamination of cytosine.


RNA polymerase-DNA complexes. 3. Binding of actinomycin D to RNA polymerase-DNA complex.


RNA polymerase-DNA complexes. IV. Influences of the ionic strength on the integrity of the complexes.


The modification of the amino terminal region of Escherichia coli proteins after initiation with methionine analogues.


Retention of ribosomal ribonucleic acids in agarose gels.


Effect of chronic administration of morphine on mouse brain aminoacyl-tRNA synthetase and tRNA-amino acid binding.


Cerebral peduncular input to mesencephalic tegmentum.


2 ,3 - Epithio-5 -androstan-17 -ol in the treatment of advanced breast cancer.


Pleural effusion in lymphoma.

Pleural effusion in lymphoma.


Non-Hodgkin's lymphomas. IV. Clinicopathologic correlation in 405 cases.


Effects of part-time "mothering" on IQ and SQ of young institutionalized children.


The surgical treatment of persistent squint.


Strabismus care: past, present and future.


Early efforts to view the human fundus.

Early efforts to view the human fundus.


An attempt towards a new approach to localized ERG.


Hermann Burian.

Hermann Burian.


Rudolf William Glaser, and Neoaplectana.


Endocrine relationships between nematodes and their insect hosts--a review.


Potentialities of mermithid nematodes for the biocontrol of blackflies (Diptera: Simuliidae)--a review.


Tabulation and evaluation of recent field experiments using the DD-136 strain of Neoaplectana carpocapsae Weiser: a review.


Identification of insect parasitic nematodes--a review.


New York Eye and Ear Infirmary dedicates temporal bone dissection lab.


Development of a viral insecticide: concept to commercialization.


The curious singing teacher.

The curious singing teacher.


Presentation of the Julius Friedenwald medal to Leon Schiff.


Calcium and gastric secretion.

Calcium and gastric secretion.


Small airways disease.

Small airways disease.


The cutaneous collagenoses.

The cutaneous collagenoses.


The cutaneous elastoses.

The cutaneous elastoses.


Disorders of the panniculus adiposus.

Disorders of the panniculus adiposus.


Circadian challenges in "quality control". Biochemical rhythms and spacial phenomena.


Mutations affecting gluconate metabolism in Escherichia coli. A mutant of Escherichia coli K-12 that does not ferment gluconate on fermentation plates was isolated and characterized. This mutant, designated M2, shows a long lag for growth on gluconate mineral medium and somewhat reduced levels of high-affinity transport, gluconokinase, and gluconate-6-P dehydrase activities in the log phase of growth. The mutation involved is near malA. Deletion mutants in which malA region was affected were also studied. They were found to affect the function of different genes involved in gluconate metabolism.


Regulatory mutations affecting the gluconate system in Escherichia coli. A spontaneously arising regulatory mutant of the gluconate system in Escherichia coli was isolated. This mutant became constitutive, probably in one step, for gluconate high-affinity transport, gluconokinase, and gluconate-6-P dehydrase. The mutation involved (gntR18) is cotransducible with asd. Pseudorevertants, derived from a mutant (M2) that shows a long lag for growth on gluconate mineral medium, were also isolated and characterized. They give constitutive levels of gluconokinase and gluconate-6-P dehydrase but lack high-affinity transport function. Genetic experiments performed with one of these pseudorevertants (M4) indicate that it carries a secondary mutation in the gntR gene. The M4 phenotype is thus the result of the interaction of expression of a constitutive mutation (gntR4) with the mutation of strain M2 (gntM2).


Osmotic pressure in Escherichia coli as rendered detectable by lysozyme attack. The enhanced susceptibility of plasmolyzed Escherichia coli to lysozyme attack was used to estimate the internal osmotic pressure of these cells under various conditions. Differences were detected between strains, culture media, stages in the growth cycle, and the osmotically active material used to produce plasmolysis. Lysozyme also was found to attack unplasmolyzed cells at 0 C and between 50 and 70 C.


Properties of a D-glutamic acid-requiring mutant of Escherichia coli. Some properties of a d-glutamic acid auxotroph of Escherichia coli B were studied. The mutant cells lysed in the absence of d-glutamic acid. Murein synthesis was impaired, accompanied by accumulation of uridine-5'-diphosphate-N-acetyl-muramyl-l-alanine (UDP-MurNac-l-Ala), as was shown by incubation of the mutant cells in a cell wall medium containing l-[(14)C]alanine. After incubation of the parental strain in a cell wall medium containing l-[(14)C]glutamic acid, the acid-precipitable radioactivity was lysozyme degradable to a large extent. Radioactive UDP-MurNac-pentapeptide was isolated from the l-[(14)C]glutamic acid-labeled parental cells. After hydrolysis, the label was exclusively present in glutamic acid, the majority of which had the stereo-isomeric d-configuration. Compared to the parent the mutant incorporated less l-[(14)C]glutamic acid from the wall medium into acid-precipitable material. Lysozyme degraded a smaller percentage of the acid-precipitable material of the mutant than of that of the parent. No radioactive uridine nucleotide precursors could be isolated from the mutant under these conditions. Attempts to identify the enzymatic defect in this mutant were not successful. The activity of UDP-MurNac-l-Ala:d-glutamic acid ligase (ADP; EC 6.3.2.9) (d-glutamic acid adding enzyme) is not affected by the mutation. Possible pathways for d-glutamic acid biosynthesis in E. coli B are discussed.


Isolation and properties of fumarate reductase mutants of Escherichia coli. Escherichia coli produces two enzymes which interconvert succinate and fumarate: succinate dehydrogenase, which is adapted to an oxidative role in the tricarboxylic acid cycle, and fumarate reductase, which catalyzes the reductive reaction more effectively and allows fumarate to function as an electron acceptor in anaerobic growth. A glycerol plus fumarate medium was devised for the selection of mutants (frd) lacking a functional fumarate reductase by virtue of their inability to use fumarate as an anaerobic electron acceptor. Most of the mutants isolated contained less than 1% of the parental fumarate reduction activity. Measurements of the fumarate reduction and succinate oxidation activities of parental strains and frd mutants after aerobic and anaerobic growth indicated that succinate dehydrogenase was completely repressed under anaerobic conditions, the assayable succinate oxidation activity being due to fumarate reductase acting reversibly. Fumarate reductase was almost completely repressed under aerobic conditions, although glucose relieved this repression to some extent. The mutations, presumably in the structural gene (frd) for fumarate reductase, were located at approximately 82 min on the E. coli chromosome by conjugation and transduction with phage P1. frd is very close to the ampA locus, and the order of markers in this region was established as ampA-frd-purA.


Cell division of Escherichia coli: control by membrane organization. Cells of certain strains of Escherichia coli, after transfer from 37 to 45 C and incubation for 16 min, were observed to swell and subsequently divide synchronously. This swelling and the resulting stretching of the membrane are proposed to be the basis for the synchronous division. Four lines of evidence support this hypothesis. First, osmotic protection by the addition of either sodium chloride or sucrose at the time of heat shock prevents both swelling and synchrony. Second, a mutant neither swelled nor divided synchronously after heat shock. Third, cells grown for several generations with 10% sucrose in the medium swelled and divided synchronously upon transfer to medium without sucrose. Fourth, the mutant not synchronized by heat shock also swelled and underwent synchronous division after the osmotic shift. A tentative model is suggested for the normal control of division, based on membrane configuration at the septation site.


Regulation of argE-argH expression with arginine derivatives in Escherichia coli: extreme non-uniformity of repression and conditional repressive action. In regulatory studies of the arginine biosynthetic system of Escherichia coli, alpha-N-acetyl-l-arginine (AcA) is a useful restrictive arginine source. In strain 39A-23R3 (argA(-)), at 25 mug/ml, AcA gives suboptimal growth rates and is fully derepressive for acetylornithinase (specified by argE) and approximately 50% derepressive for argininosuccinase (specified by argH). At 10 mug/ml, the growth rate decreases, whereas the extent of derepression is unchanged; at 500 mug/ml, full repression results. In strain 3670 (argB(-)argG(-)), AcA (25 mug/ml) leads to partial derepression of acetylornithinase but full repression of argininosuccinase. Thus, the repression patterns for both strains, although not identical, are nonuniform. AcA utilization is antagonized by alpha-N-acetyl-l-ornithine (AcO). In strain 3670 (blocked before and after acetylornithinase), the growth rate on AcA (25 mug/ml) is lowered by AcO (500 mug/ml); acetylornithinase is completely derepressed, whereas argininosuccinase is fully repressed. This difference in regulatory behavior represents extreme nonuniform repression. Unexpectedly, the effect of AcO is attributable to the conversion of AcO to citrulline (Cit). In strain 3670, mixtures of AcA (25 mug/ml) and Cit (300 mug/ml) permit complete derepression of acetylornithinase; there is evidence that Cit enters the cell. In contrast, in the arginine-limited chemostat, Cit represses acetylornithinase. These opposite regulatory effects of Cit appear to stem from the difference in arginine restriction. AcA enters the cell via AcO permease and is deacylated by acetylornithinase (K(m), 5.0 mM). AcA competitively inhibits AcO cleavage (K(i), 2.4 mM), but Cit is not inhibitory. The antagonism of AcA utilization by AcO or Cit is thought to be exerted at the AcO permease.


Metabolism of D-serine in Escherichia coli K-12: mechanism of growth inhibition. Without significant killing, d-serine at concentrations greater than 50 mug/ml inhibits growth in minimal media of mutants of Escherichia coli K-12 unable to form d-serine deaminase. The mutants eventually recover at lower concentrations. There is no evidence of d-serine toxicity in rich media. Toxicity is partially reversed by l-serine. d-Serine does not interfere with l-serine activation, one-carbon metabolism, or (Cronan, personal communication) formation of phosphatidylserine. Pizer (personal communication) finds, however, that it is a powerful feedback inhibitor of the first enzyme of l-serine biosynthesis. In the presence of l-serine, the residual toxicity is largely and noncompetitively over come by pantothenate, indicating that d-serine inhibits growth by affecting two targets: pantothenate biosynthesis and l-serine biosynthesis. l-Serine causes transient growth inhibition in E. coli K-12. Contaminating l-serine in d-serine preparations contributes to the d-serine inhibitory response.


D-serine transport system in Escherichia coli K-12. The d-serine transport system in Escherichia coli K-12 was studied by use of a mutant unable to form d-serine deaminase, yet resistant to d-serine. The mutant is greatly impaired in its ability to accumulate d-serine, d-alanine, and glycine. Transport of l-alanine is partially affected but transport of l-serine is unaffected. The mutant is also resistant to d-cycloserine, indicating that d-serine is transported by the system responsible for uptake of d-cycloserine. The d-serine transport system is not inducible, but appears to be formed constitutively, as are the transport systems of most amino acids. The transport mutation appears to be multistep and maps to the right of malB on the E. coli linkage map.


Enzyme complex which couples glycerol-3-phosphate dehydrogenation to fumarate reduction in Escherichia coli. Anaerobic growth of Escherichia coli on glycerol as carbon source and fumarate as hydrogen acceptor results in the induction of both anaerobic sn-glycerol-3-phosphate (G3P) dehydrogenase and fumarate reductase. In previous studies, the G3P dehydrogenase was measured by the G3P-dependent reduction of a tetrazolium dye mediated by phenazine methosulfate in the presence of flavine mononucleotide and flavine adenine dinucleotide, and fumarate reductase was measured by the fumarate-dependent oxidation of reduced flavine mononucleotide. Results from the present study indicate that these two enzymes actually constitute a functional complex which is sedimentable at 200,000 x g in 2 h and which can catalyze the dehydrogenation of G3P at the expense of fumarate without any added cofactor. This coupling activity is not constituted by simply mixing an extract containing anaerobic G3P dehydrogenase with another extract containing fumarate reductase. Additional evidence for an organized complex is provided by the high degree of sensitivity of the coupled reaction to low concentrations of the detergents Triton X-100 and Emasol 1130 in comparison with the individual activities of the two component enzymes measured with the aid of artificial cofactors.


Membrane translocation of mannitol in Escherichia coli without phosphorylation. Galactosyl-mannitol can be transported into cells of Escherichia coli by beta-galactoside permease and can be hydrolyzed rapidly to mannitol and galactose by beta-galactosidase. When a mutant strain lacking enzyme I of the phosphoenolpyruvate phosphotransferase system and constitutive in the lactose system was presented with galactosyl-mannitol in which the mannitol moiety was labeled with (3)H, the liberated mannitol remained inside the cell if the Enzyme II complex of the phosphoenolpyruvate phosphotransferase system for mannitol was uninduced. It is postualted that one of the enzyme II proteins can still catalyze translocation of mannitol across the cell membrane even when phsophorylation is not possible.


Subapical wall synthesis and wall thickening induced by cycloheximide in hyphae of Aspergillus nidulans. Hyphae of Aspergillus nidulans continued to synthesize all the major polysaccharide components of the cell wall when cycloheximide was added to cultures. In the presence of cycloheximide, hyphae did not elongate, but electron microscopy showed that the walls became thicker around the cell. The conclusion that cycloheximide changed wall synthesis from extension at the apex to subapical thickening was supported by grain distributions on radioautograms of mutant hyphae labeled with galactose. These findings are discussed in relation to the control of hyphal wall synthesis and are compared with the effects of protein synthesis inhibitors on wall formation in gram-positive bacteria.


Cell division and deoxyribonucleic acid synthesis after a nutritional shift-up of Saccharomyces cerevisiae. Rates of cell division and deoxyribonucleic acid synthesis after shift-up with grande and mitchondrial deoxyribonucleic-acid-less petite yeasts were studied. The results indicate that simple eukaryotes behave as prokaryotes.


Inhibition of spore outgrowth and vegetative growth of Bacillus stearothermophilus by dipicolinate. Spores of Bacillus stearothermophilus germinated in the presence of sodium dipicolinate (DPA) but did not elongate after the emergence stage of outgrowth. Vegetative growth also was inhibited by Na(2)DPA.


Changes in cell size and shape associated with changes in the replication time of the chromosome of Escherichia coli. Average cell mass is shown to be inversely related to the concentration of thymine in the growth medium of a thy(-) strain of Escherichia coli. The kinetics of the transition from one steady-state average cell mass to another was followed in an attempt to determine the relationship between the chromosome replication time and the time between completion of a round of chromosome replication and the subsequent cell division. Differences in average cell mass are shown to be associated with similar differences in average cell volume. Changes in volume associated with changes in thymine concentration are shown to be due primarily to differences in the width of cells. It is proposed that extension in length of the cell envelope occurs at a linear rate which is proportional to the growth rate and which doubles at the time of termination of rounds of replication. Changes in volume not associated with a change in growth rate are therefore accommodated by a change in cell width. Conditions are described under which average cell mass can continue to increase in successive generations and no steady-state average cell mass is achieved.


Phosphorylation of glycerol in Staphylococcus aureus. Staphylococcus aureus dissimilates glycerol via an adenosine triphosphate-dependent kinase and not by the phosphoenolpyruvate phosphotransferase system.


Selective autocytotoxicity in a model system of Escherichia coli K-12 recombinants. Autocytotoxicity was shown by Lac(+) recombinant strains of Escherichia coli K-12 when their growth was inhibited in media containing o-nitrophenyl-beta-d-galactopyranoside. Lac(-) strains without lactose permease or beta-galactosidase activity grew well. Selective autocytotoxicity was shown by simultaneous inhibition of Lac(+) cells and multiplication of Lac(-) cells grown together in this medium.


Transcriptional control of the calactose operon by the capR (lon) and capT genes. Mutations in capR or capT cause derepression of the enzymes of the gal operon. The gal-specific messenger ribonucleic acid is directly proportional to the gal enzyme levels in wild type, capR, and capT strains. These results indicate that capR and capT control the gal operon at the transcriptional level.


Site of catabolite inhibition of carbohydrate metabolism. Glucose produces catabolite inhibition during its transport across the cell membrane. Glucose generated intracellularly does not produce catabolite inhibition but does produce catabolite repression.


Quantitation of endogenous and exogenous gonadotropin releasing hormone by radioimmunoassay.


Differences in spatial discrimination reversal learning between two inbred mouse strains following specific amygdaloid lesions.


Receptive fields in deep layers of cat superior colliculus.


The development of fixed-ratio performance under the influence of ribonucleic acid. The transition from fixed-ratio 1 performance (every response reinforced) to fixed-ratio 30 performance (every thirtieth response reinforced) was studied in nine pigeons. These were divided into three treatment groups given daily oral doses of saline, or 250 mg/kg/day or 500 mg/kg/day of yeast ribonucleic acid. Detailed computer-assisted analyses of how fixed-ratio behavior develops revealed the following typical sequence. After the transition, the first few ratios typically were emitted without long interresponse times within the ratio. Steady responding then ceased, and numerous long interresponse times occurred, with no systematic relationship to ordinal position within the ratio. Gradually, a new pattern evolved, characterized by a consistently long post-reinforcement time, a border region of the next few interresponse times within which the mean interresponse time monotonically decreased, and short interresponse times within the last 80% of the ratio. Long interresponse times were eliminated from this last section of the ratio without regard to proximity to reinforcement. Various analytical procedures suggested that the final pattern can be conceived, in part, as the shaping of a reliable response topography. The group of three pigeons given 250 mg/kg/day of yeast ribonucleic acid responded at higher rates than the saline and 500 mg/kg/day groups. The latter group, in contrast to the saline and lower dose groups, which continued to increase their rates, reached a rate asymptote very early.


Medial geniculate body of the cat: responses to tonal stimuli of neurons in medial division.


Posterior hypothalamic neurons responsive to preoptic region thermal stimulation.


Fraser Mackintosh Rose.

Fraser Mackintosh Rose.


The therapeutic effect of amantadine in influenza occurring during the winter of 1971-2 assessed by double-blind study.


Diabetes mellitus--some reflections.

Diabetes mellitus--some reflections.


The foundation of a college. The conception, birth, and early days of the College of General Practitioners.


Biochemistry of the renal glomerular basement membrane and its alterations in diabetes mellitus.


Cable from Cathay.

Cable from Cathay.


Francis Minot Rackemann, M.D.

Francis Minot Rackemann, M.D.


Effect of cigarette smoking on primary and secondary humoral responses of mice.


Effect of prohibition of the use of tetracyclines in animal feeds on tetracycline resistance of faecal E. coli of pigs.


On nursing care plans and their history.


Baccalaureate and masters degree programs in nursing accredited by NLN--1973-4.


The Goldmark report: midpoint in nursing history.


Personal memories of Mrs. Bedford Fenwick.


Zymogens of proteolytic enzymes.

Zymogens of proteolytic enzymes.


Stereotaxic investigation of the lateral horn of the cat spinal cord.


An ultrastructural study of the frog retinal rod photreceptor membranes phagocyted by pigment epithelium cells after aldehyde fixations and organic solvents treatments.


The ultrastructural organization of the photoreceptor membranes and the intradisc spaces of the vertebrate retina as revealed by various experimental treatments.


Nigro-neostriatal projection. A correlative study with Fink-Heimer impregnation, fluorescence histochemistry and electron microscopy.


Effect of the method of administration on the invasive capacity of Salmonella.


Stanley W. Wright, M.D., (1921-1971).

Stanley W. Wright, M.D., (1921-1971).


Self identification in the Make-A-Picture Story protocols of a group of retarded boys.


Cataract extraction after successful penetrating keratoplasty.


Exogenous mycotic keratitis caused by blastomyces dermatitidis.


Effects of subconjunctival pimaricin in experimental keratomycosis.


New corneal transplant scissors.

New corneal transplant scissors.


Introduction of Carlos Sanmartín B. as Charles Franklin Craig lecturer for 1972.


Recrudescent falciparum malaria in Vietnam.


A malaria epidemic among heroin users.

A malaria epidemic among heroin users.


A comparative evaluation of sulfalene-trimethoprim and sulphormethoxine-pyrimethamine against falciparum malaria in Thailand.


Rearing of the adult Echinococcus multilocularis Leuckart, 1863, from sterile larvae from man.


Nasal entomophthorosis. Preliminary immunopathological study of a new case.


Sound production evoked by electrical stimulation of the brain in toadfish (Opsanus beta).


Repetitive vocalizations evoked by local electrical stimulation of avian brains. I. Awake chickens (Gallus Gallus).


Fibroblastic ingrowth following cataract extraction.


Endothelial rejection in human transplants.


Analysis of adeno-associated satellite virus DNA.


Chromosomal and plasmid DNA of bacteria: interaction with crystals of cadmium lauroyl sarkosinate.


Occurrence of repetitive sequences in the DNA of some marine invertebrates.


Preparation of a stable mercury derivative of tyrosine transfer RNA.


Comparison of rat liver and Escherichia Coli cell-free systems in inhibition of polypeptide synthesis by deoxycholate.


The action of novel chloramphenicol analogues on prokaryotic and eukaryotic systems.


The function of plastoquinone in photosynthetic electron transport.


Utilization of energy for growth and maintenance in continuous and batch cultures of microorganisms. A reevaluation of the method for the determination of ATP production by measuring molar growth yields.


Scleromyxoedema (lichen myxoedematosus) associated with a paraprotein, IgG 1  of type kappa.


Immunological associations of the halo naevus with cutaneous malignant melanoma.


Studies on a patient with leucocytoclastic vasculities 'pyoderma gangrenosum' and paraproteinaemia.


A case of pemphigus vulgaris in association with Addisonian pernicious anaemia.


Ultrastructural aspects of pemphigoid.

Ultrastructural aspects of pemphigoid.


Oral   carotene therapy in actinic reticuloid and solar urticaria. Failure to demonstrate a photoprotective effect against long wave ultraviolet and visible radiation.


Deep venous thrombosis. II. Management.

Deep venous thrombosis. II. Management.


The protection of damaged tissue by skin cover.


A de-epithelialised overlap flap technique in the repair of hypospadias.


A clinical trial of the use of 5-fluouracil in the treatment of some cutaneous malignancies.


Use of lyophilised pig skin for donor site cover.


The vascular basis of axial pattern flaps.


Pretibial lacerations.

Pretibial lacerations.


The cone flap for resurfacing reconstructing partial digits.


Calcification in dermofat grafts.

Calcification in dermofat grafts.


A case of familial dysautonomia: cutting skin grafts without anaesthesia.


The effect of topical ampicillin on wound-infection rate after cholecystectomy.


The management of varicose veins.

The management of varicose veins.


A controlled trial of closed wound suction.


Gastric ulcer treated by vagotomy, pyloroplasty, and ulcerectomy.


The autogenous saphenous vein loop for haemodialysis.


Reno-broncho-pyelo-cutaneous fistula.

Reno-broncho-pyelo-cutaneous fistula.


Division of the external sphincter.

Division of the external sphincter.


Occurrence of aging pigment (Lipofuscin) in the nuclei and cortices of the canine brain.


Medicare's current financing recall.

Medicare's current financing recall.


Separation and characterization of cell subpopulations in the thymus.


Lack of correlation between the effects of cortisone on mouse spleen plaque-forming cells and circulating anti-sheep red blood cell haemolysins.


Histoimmunochemical localization of three guinea-pig spermatozoal autoantigens.


Cytotoxicity of immune guinea-pig cells. II. The mechanism of macrophage cytotoxicity.


Direct conversion of precursors of PFCs into active PFCs in vitro, without prior cell division.


Regulation of the immune response. VII. In vitro immunosuppression by F(ab') 2  or intact IgG antibodies.


Developed  M haemolytic plaque-forming cells in chickens.


Stimulation of humoral immune response by tilorone hydrochloride.


Parasitological societies of the world.

Parasitological societies of the world.


Regulatory mechanisms of territorial marking in the Mongolian gerbil.


Schedule-induced polydipsia: effect of water temperature, ambient temperature, and hypothalamic cooling.


EEG seizure anomalies following supramaximal intensities of cortical stimulation: relationships with passive-avoidance retention in rats.


Relationships between Conceptual Style Test and Children's Embedded Figures Test.


Previous stimulus experience delays conditioning-induced changes in hippocampal unit responses in rats.


A comparison of the retention of complete denture bases having different types of posterior palatal seal.


Classification and selection of attachments.


Dynamic stresses encountered in impression removal.


Complete crowns constructed for an existing partial denture.


Surface roughness of castings made by various casting techniques.


Copper-band gingival retraction to produce void-free crown and bridge impressions.


The use of standardized tapered plastic pins in post and core fabrication.


Dr L. S. B. Leakey.

Dr L. S. B. Leakey.


Brand new.

Brand new.


Carbonic anhydrase and bone resorption.

Carbonic anhydrase and bone resorption.


Fat-controlled diet and mortality from coronary heart disease.


Activity and energy intake in Ugandan children.


Niacin and myocardial metabolism.

Niacin and myocardial metabolism.


The growth of children given stimulant drugs.


Implicit personality theory: a vreview.

Implicit personality theory: a vreview.


Implosive therapy and flooding procedures: a critical review.


Transfer of experimental autoimmune renal cortical tubular and interstitial disease in guinea pigs by serum. Guinea pigs injected with rabbit tubular basement membranes and Freund's adjuvant develop progressive renal cortical tubulointerstitial disease and deposit autoantibodies in their cortical tubular basement membranes. The identical, even fatal, disease may be produced in normal guinea pigs by a single intraperitoneal injection of serums obtained from guinea pigs with this tubulointerstitial disease, provided such serums contain sufficient amounts of autoantibodies against tubular basement membranes.


Are cell membranes fluid?

Are cell membranes fluid?


Role of pressure in the stabilization and destabilization of bacterial spores.


Effects of pressure on the metabolic processes of plants.


The physics and chemistry of high pressures.


The role of high hydrostatic pressure in the physiology of marine animals.


Buoyancy mechanisms of cephalopods in relation to pressure.


Swimbladder organization and depth ranges of deep-sea teleosts.


The energetics of vertical migration by fishes.


Effects of pressure on the dissociation of weak acids.


Some problems of human diving.

Some problems of human diving.


Deep diving behaviour and effects of pressure in reptiles, birds, and mammals.


Inert gas narcosis and animals under high pressure.


Human respiration under increased pressures.


Detection of small changes in hydrostatic pressure by crustacea and its relation to electrode action in the cuticle.


Effects of pressure on the structure of water in various aqueous systems.


Bacteriophage P2 head morphogenesis: cleavage of the major capsid protein.


Prophage excision: specific gene amplification of excision-impaired lysogen after induction.


Satellite bacteriophage P4: characterization of mutants in two essential genes.


Transcription of double-stranded RNA in cytoplasmic polyhedrosis virus in vtro.


Mutants of bacteriophage T4 which allow amber mutants of gene 32 to grow in ochre-suppressing hosts.


Anton Weichselbaum on the etiology of acute endocarditis--1885.


Intergenic suppression of amber polynucleotide ligase mutation in bacteriophage T4. II.


Intracardiac foreign body simulating double-chamber right ventricle.


Intra-abdominal abscess.

Intra-abdominal abscess.


Perinephric abscess: an unusual presentation.


A positive end-expiratory pressure-nasal-assist device (PEEP-NAD) for treatment of respiratory distress syndrome.


The Appalachian coal miner: his way of living, working, and relating to others.


Lymphatic drainage of the lung in dust clearance.


Electron microscopic findings in the lungs of miners.


Clinical disorders of urine concentration and dilution.


The role of aldosterone in renal physiology.


Erythropoietin.

Erythropoietin.


Pathophysiology of acute renal failure.

Pathophysiology of acute renal failure.


Diet, nutrition, and masticatory ability in a group of elderly edentulous patients.


Splitting of teeth for abutments.

Splitting of teeth for abutments.


Radiosensitization of anoxic cells by metronidazole.


Multiple organ grafts in the pig. Techniques and results of pancreatic, hepatic, cardiac, and renal allografts.


Diet and congenital defects.

Diet and congenital defects.


Restoration by fatty acids of active transport in a lactose transport mutant of Escherichia coli.


The selenium paradox.

The selenium paradox.


Cellular localization of gastric inhibitory polypeptide in the duodenum and jejunum. Indirect immunofluorescence studies using an antiserum to purified porcine gastric inhibitory polypeptide indicate, in the gastrointestinal tract of dog and man, that this polypeptide is present in cells situated predominantly in the mid-zone of the glands in the duodenum and, to a lesser extent, in the jejunum. Absolute correlation of the gastric inhibitory polypeptide cell with one or other of the known endocrine-like cells identified by electron microscopy awaits confirmation by electron immunocytochemistry. It is here identified as an endocrine polypeptide cell of the APUD series and, provisionally, as the D(1) cell. While the hormonal status of a given polypeptide depends ultimately on physiological experiments the present results strengthen the view that gastric inhibitory polypeptide is indeed a hormone.


Antireticulin antibody: incidence and diagnostic significance. Sera from 101 patients with adult coeliac disease, 46 patients with childhood coeliac disease, 50 patients with dermatitis herpetiformis, and 479 patients with various other diseases, including skin, gastrointestinal, haematological, and immunological disorders, have been tested for the presence of the antireticulin antibody. Positive sera were retested at higher dilutions. Antireticulin antibody was only found in a significant proportion of patients with three diseases, ie, coeliac disease, dermatitis herpetiformis, and Crohn's disease. Antireticulin antibody was present in 38 out of 101 patients (38%) with adult coeliac disease, 27 out of 46 patients (59%) with childhood coeliac disease, 11 out of 50 patients (22%) with dermatitis herpetiformis, and nine out of 38 patients (24%) with Crohn's disease. In the 434 other patients with various disorders the antireticulin antibody was present in only six 1.4%) (two patients were pregnant, one had vitiligo, one had tropical sprue, one had reticulum cell sarcoma, and one had pernicious anaemia). In patients with gluten-sensitive enteropathy, ie, coeliac disease and dermatitis herpetiformis, there was a significantly higher incidence in patients taking a normal diet compared with those on a gluten-free diet. The presence of antireticulin antibody would appear to be particularly helpful in diagnosing childhood coeliac disease as it was found in 22 out of 26 patients (85%) taking a normal diet.


Central nervous system mediated inhibition of insulin secretion due to 2-deoxyglucose.


The effect of L-dopa on insulin release by isolated pancreatic islets of the rat.


Mechanisms and prediction of drug-induced liver disease.


The importance of the guanidine group in the insulin-stimulatory effect of amiloride hydrochloride.


Insulin concentrations in portal venous and peripheral venous blood in man following administration of glucose, galactose, xylitol and tobutamide.


Effect of sublingual, intravenous and intramuscular administration of synthetic LH-releasing hormone in the human.


The usefulness of treponema pallidum haemagglutination (TPHA) and enzyme marker peroxidase (Px) tests for the serodiagnosis of syphilis.


Obituary. Dr. Jyoti Bhusan Chatterjea.

Obituary. Dr. Jyoti Bhusan Chatterjea.


Site of action of tetanus toxin in the central nervous system--subcellular site of binding of tetanus toxin in the cerebrum.


Experimental evaluation of various methods used for prolongation of skin homografts--studies done in rats and rabbits.


Obituary. Professor Otto Jírovec.

Obituary. Professor Otto Jírovec.


Obituary. Professor Zbigniew Kozar.

Obituary. Professor Zbigniew Kozar.


Quantification of two projective tests for deaf clients: a large sample validation study.


Viruses and the respiratory tract in sudden infant deaths.


The problem of the acquired B antigen in forensic serology.


Bovine mycoplasmas: genome size and base composition of DNA.


Comparison of Hansenula wingei, a petite-negative, obligately aerobic yeast, to the petite-positive yeast Saccharomyces cerevisiae.


Morphological mutants of Escherichia coli. Isolation and ultrastructure of a chain-forming envC mutant.


David Livingstone, 1813-1873: his contribution to medicine.


Reproduction rates of infection during the 1967-1968 P. vivax malaria epidemic in Sri Lanka (Ceylon).


Candidal cystitis. Management by continuous bladder irrigation with amphotericin B.


Dermatophyte Test Medium for systemic fungi.


Florence Nightingale's values and modern nursing education.


Techniques for continuous measurement of local cerebral blood flow, PaO 2  , PaCO 2  and blood pressure in the non-anesthetized animal.


The influence of coronary pressure and coronary flow on intracoronary blood volume and geometry of the left ventricle.


Transport of 3-O-methyl-D-glucose into mammalian pancreatic  -cells.


Photochemistry and structure in nucleic acids.


The effects of a single administration of etifoxine on several psychological tests.


Development of rabbit visual cortex: late appearance of a class of receptive fields. In young rabbits before the age at which the eyes open, only three of the seven receptive field types described in the adult visual cortex are detectable. The remaining four receptive field types-which share the property of having radially asymmetric fields-appear later, coincident with a decline in the percentage of cells that are visually responsive but not classifiable as to receptive field type.


Personal preferences in anesthesia.

Personal preferences in anesthesia.


Treatment of thermal injuries.

Treatment of thermal injuries.


Selection and management of patients for renal transplantation.


Sexual norms under the influence of altered cultural patterns in Greenland.


Closed stereotaxic hypophysectomy by means of  60 Co gamma radiation.


Isolation of swine papvovirus in Queensland.


Consent and living donors of organs.

Consent and living donors of organs.


Additional bibliography on arctic ophthalmology.


Double-blind controlled comparison of lorazepam and glutethimide as night-before-operation hypnotics.


A decade of northern ophthalmology.

A decade of northern ophthalmology.


Continuous positive airway pressure as an adjunct to mechanical ventilation in the newborn with respiratory distress syndrome.


Trauma in the orbital regions (exclusive of fractures).


The perfect anaesthetic. Anaesthesia by the method of Paul Bert: Surgo, vol. VII, No. 2, 1941.


Platelet aggregation in corneal xenograft reaction.


Positive-pressure ventilation during anesthesia for bronchoscopy: a laboratory evaluation of two recent advances.


Washington sees changes on way in U.S. health care. But does change necessitate revolution?


We salute Perry P. Volpitto, M.D.

We salute Perry P. Volpitto, M.D.


Treatment of renal failure from diabetic nephropathy with cadaveric homograft. We report two patients with terminal renal failure secondary to diabetic nephropathy treated with cadaveric kidney transplantation. Neither of these patients had peripheral vascular disease or peripheral neuropathy. There was a proliferative diabetic retinopathy with hemorrhages and exudates in one patient and only background diabetic changes in the ocular fundi of the other; there have been no significant changes in visual acuity or retinopathy in either patient following the transplantation. Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency.


Influence of various cooling and warming temperatures on survival after thawing of cryopreserved Plasmodium berghei.


Renal preservation by hypothermic perfusion. I. The importance of pressure-control.


Effects of cold storage on the function of isolated pancreatic islets.


Blockade of the release of gonadotropins and prolactin by subcutaneous or intraventricular injection of atropine in male and female rats.


Evidence for a pituitary site of action for the acute inhibition of LH release by estrogen in the rat.


Preparation and properties of 125-I-LHRH.


Comparative efficacy of pheniramine maleate and a combination of pheniramine maleate with prednisolone in reducing histamine induced triple response of the skin.


Obituary : Dr. M. M. Mehta.

Obituary : Dr. M. M. Mehta.


Dr. Paul Bert (1833-1886).

Dr. Paul Bert (1833-1886).


Detection of humoral antibody to the transmissible venereal tumour of the dog.


Clinical evaluation of complete dentures constructed from pour resins.


Presence of carcinoembryonic antigen in children's colonic mucosa.


National Eye Institute: summary report of the cornea task force.


The endo-trans and poly-trans implants--a solution to the problem of masticatory stresses on implants.


John Ross Callahan.

John Ross Callahan.


Dental cabinet nostalgia.

Dental cabinet nostalgia.


Problems associated with the use of the knee-chest position for operations on lumbar intervertebral discs.


The role of fluorine-18 and strontium-87m scintigraphy in the management of infective spondylitis.


In memoriam. Sir Reginald Watson-Jones.

In memoriam. Sir Reginald Watson-Jones.


Recombined grafts of bone and marrow. The beneficial effect upon osteogenesis of impregnating xenograft (heterograft) bone with autologous red marrow.


Ivor Murray Robertson.

Ivor Murray Robertson.


William Frame White.

William Frame White.


Graeme Ballantyne Smaill.

Graeme Ballantyne Smaill.


The histochemical fluorescence method for the demonstration of catecholamines. Theory, practice and application.


Transmission of type B viral hepatitis to chimpanzees.


Notes on synaptic vesicles and related structures, endoplasmic reticulum, lysosomes and peroxisomes in nervous tissue and the adrenal medulla.


Effect of pH on in vitro activity of carbenicillin aganist Proteus mirabilis.


Passage in ferrets of encephalitogenic cell-associated measles virus isolated from brain of a patient with subacute sclerosing panencephalitis.


Disseminated cryptococcosis in man: decreased lymphocyte transformation in response to Cryptococcus neoformans.


Effect of pH and iron concentration on growth of Candida albicans in human serum.


Host-parasite relationships in urinary tract infections.


Some ancient mysteries reexplored. 3. Flaming waters.


Prevalence of respiratory signs and symptoms among U.S. cotton textile workers.


Ovulation, fertility and prenatal mortality in heifers treated with PMSG or porcine FSH.


Removal of acrosomes of ram and rabbit spermatozoa.


Dr. Benjamin B. Brumbaugh. One-of-a-kind family doctor.iver DNA.


Hippocrates: medical giant in the saga of man.


Dr. Kinsey and the Institute for Sex Research.


The rapid plasma reagin (circle) card test: a screening test for syphilis.


Reginald George Worcester.

Reginald George Worcester.


Harry Carew Nott.

Harry Carew Nott.


Neural regulation of growth hormone secretion.


The one-layer and two-layer intestinal anastomosis in animal experiments.


Compatibility of biomaterials.

Compatibility of biomaterials.


Long-term psychological effects of LSD.

Long-term psychological effects of LSD.


Neglected developmental variables in the study of species identification in birds.


Theories of dream function.

Theories of dream function.


Latent inhibition.

Latent inhibition.


Bronchiectasis, suppurative lung disease and respiratory failure after removal of an intrabronchial foreign body. A case report with a 26-year follow-up.


Chlorhexidine as a denture disinfectant in the treatment of denture stomatitis.


Comparison of dental health data obtained from questionnaires, interviews and clinical examination.


A method for isolation of anaerobic bacteria from endodontic specimens.


Clinical trial with terbutaline and guajacol.


Erythromycin.

Erythromycin.


Background of the recognition of Klinefelter's syndrome as a distinct pathologic entity.


Vasectomy--reviewed.

Vasectomy--reviewed.


Prenatal immunization and protection of the newborn: ovine and bovine fetuses vaccinated with Escherichia coli antigen by the oral route and exposed to challenge inoculum at birth.


A new fla gene in Salmonella typhimurium--flaR--and its mutant phenotype-superhooks.


Escherichia coli endotoxemia in conscious calves.


Characterisation of Escherichia coli cell surface by isoelectric equilibrium analysis.


The significance of membrane alterations seen in DNA synthesis mutants of Escherichia coli.


Effect of changes in fatty acid composition of phospholipid species on the  -galactoside transport system of Escherichia coli K-12.


Studies of the neutropenia of acute malaria.


Red Cross outpost nursing in New Brunswick.


Lymphography in malignant lymphomas--an analysis of 400 cases.


Speech and portrait presentation by Dr. Jack Edeiken (Philip J Hodes).


Bibliography of thermoluminescent dosimetry (1968-1972).


Neighborhood health centers and evaluation literature: a selected annotated bibliography.


Cardiac transplantation. Immunosuppressive role of anticoagulation.


Surgical anatomy of the gastroduodenal artery.


Prevention of abdominal disruption and postoperative hernia.


The camouflage phenomenon in several species of Triatominae (Hemiptera: Reduviidae).


Simon P. Hullihen: surgeon, teacher, humanitarian.


Hemodialysis and renal transplantations: an integrated approach.


The role of personal history data in clinical judgment: a selective focus.


Blind test interpretation to overcome student resistance to projective techniques courses.


The Children's Apperception Test: puzzle and regular form.


A new experimental approach to the relationship between color-shading and suicide attempts.


Some relations between parental personality factors and childhood symtomatology.


Bacterial cell model. Cell cycle parameters and macromolecular synthesis.


Stereotactic neurosurgery for aggressive behaviour.


Cephalexin in the treatment of urinary infection in childhood.


Extracranial arterial reconstruction for transient ischaemic attacks.


Total avulsion of the scalp.

Total avulsion of the scalp.


Artificial kidneys in the seventies.

Artificial kidneys in the seventies.


Uric acid transport in renal failure. A review.


Dr. F. R. MacKinnon talks to the bulletin: public health and social welfare.


An appreciation. Allan Reid Morton.

An appreciation. Allan Reid Morton.


Pediatrics and the adolescent. Presentation of the C. Anderson Aldrich Award to J. Roswell Gallagher.


Pediatrics and the adolescent. Remarks on receiving the C. Anderson Aldrich award.


The unique fetal red cell and its function. E. Mead Johnson Award address.


Psychotropic medication with children: an evaluation of procedural biases in results of reported studies.


Withering's account of foxglove and its use in children.


Fables for the instruction of youth published in Boston in 1818. IX. The Hermit.


Oculoglandular tularemia in an inner city child.


Development of a scale to measure nurses' trust of patients: a preliminary report.


X-ray studies of crystalline proteins.

X-ray studies of crystalline proteins.


The isolation of a train of bovine syncytial virus in Northern Ireland.


Some effects of Escherichia coli enterotoxin on undirectional fluxes of water and sodium in calf Thiry-Vella loops.


Uptake and pathogenesis of Escherichia coli 055:B 5  in the young gnotobiotic pig.


O-groups of Escherichia coli associated with canine pyometra.


Pesticides and the soil fauna.

Pesticides and the soil fauna.


Sodium handling by the kidney in health and disease. A review.


In memoriam: Samuel Barrow Lange.

In memoriam: Samuel Barrow Lange.


NIH director Stone: another manager on Nixon's health team.


Dynamics of number fluctuations: motile microorganisms. The time dependence of the intensity of light scattered from motile Escherichia coli bacteria is studied in population densities so low that the intensity autocorrelation function reflects fluctuations in the total number of particles in the scattering region. Measured correlation functions are analyzed by using a random walk model of bacterial motion.


Co-transduction mapping in Serratia marcescens.


Bacteriological evaluation of the course of urinary tract infections treated with trimethoprim and-or sulphamethoxazole.


Late urological complications following human kidney transplantation. A comparison of the findings following uretero-pyelostomy and uretero-cystostomy.


Topical use of penicillin-streptomycin in the prophylaxis of wound infection after gastric operations.


Primary hyperparathyroidism.

Primary hyperparathyroidism.


Analysis of a bladder stone in 1786.

Analysis of a bladder stone in 1786.


Uroscopia. A historical and art historical essay.


Introduction of chloroform into Denmark.


Leiomyosarcoma of the prostate.

Leiomyosarcoma of the prostate.


Studies on experimental pneumonitis in rat induced by anti-rat-lung serum.


What ever happened to chlorosis?

What ever happened to chlorosis?


Nonspecific protective substances of serum in protein deficiency: an in vitro experimental study.


Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach.


Proposed role of copper-molybdenum interaction in iron-deficiency and iron -storage diseases.


Microcirculation.

Microcirculation.


Local control of regional blood flow.

Local control of regional blood flow.


Respiration: pulmonary mechanics.

Respiration: pulmonary mechanics.


The physiology of exercise under heat stress.


The ontogenesis of one physiologist.

The ontogenesis of one physiologist.


Status of mycobacterial infections of the lungs.


Hemodynamics.

Hemodynamics.


Antimicrobial susceptibility testing by the Kirby-Bauer disc diffusion method.


Present status of laboratory diagnosis of sarcoidosis.


Respiratory diseases in relation to changes in atmospheric pressure.


Comparative physiology: pineal gland.

Comparative physiology: pineal gland. Literature on the endocrinologic function of the pineal gland is reviewed.  The pineal gland appears to have an inhibitory effect on gonadtoropin release.  It is possible, since no hypothalamic inhibiting factors have been indentified with the control of luteinizing hormone (LH) and follicle stimulating hormone synthesis and release by the anterior pituitary, that the pineal gland provides the necessary inhibitory principles.  The antigonadotropic activity of pineal polypeptides may be of importance in this regard.  In that these polypeptides are not present in the urine of pinealectomized rats, it is assumed that they are secreted by the pineal gland.  Although the effects of the pineal gland on sexual physiology in animal experiments performed under phototropic conditions are barely detectable, it is incorrect to assume that the organ has no function.  Exposure to artificial light for 12-16 hours may severely bias or negate the effect of the pineal gland.  In that the pineal gland influences brain constituents and, possibly, synaptic transmission, it is likely that it may control the peripheral organs of internal secretion by a mechanism involving corticol indoleamine and catecholamine concentrations.


Residential psychedelic (LSD) therapy for the narcotic addict. A controlled study.


Low doses of Dipropyltryptamine in psychotherapy.


Pathological features of Trypanosoma cruzi infections of Rattus rattus.


Neoplasms in Wistar rats after an n-methyl-n-nitrosourea injection.


Palatal lift and speech therapy for velopharyngeal incompetence.


Nature of trimethoprim-induced death in Escherichia coli.


Effects of trimethoprim on Escherichia coli under limited nutrition.


Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus.


Differential effects of sigma factor, ionic strength, and ribonucleoside triphosphate concentration on the transcription of phage T4 DNA with ribonucleic acid polymerase of Escherichia coli.


A simple method of preparing large amounts of phiX174 RF 1 supercoiled DNA.


Mutants for the specific labelling of DNA in Saccharomyces cerevisiae.


How the computerized electrocardiogram is used in industrial medicine.


Size of polysome involved in the synthesis of T4 phage lysozyme.


Preparation of  125 I-Catalytic subunit of asparatate transcarbamylase and its use in studies of the regulatory subunit.


The cysteine desulfhydrase of Salmonella typhimurium. Formation of an altered enzyme by cryloysis.


Composition of bovine milk lipids.

Composition of bovine milk lipids.


Kinetic properties and inhibition of orotidine 5'-phosphate decarboxylase. Effects of some allopurinol metabolites on the enzyme.


The nucleotide sequence of Saccharomyces cerevisiae 5.8 S ribosomal ribonucleic acid.


Catalytic and allosteric properties of glycerol kinase from Escherichia coli.


Preparation of pancreatic ribonucleases 1-114 and 1-115 and their reactivation by mixture and synthetic COOH-terminal peptides.


Effect of lactose content and milking interval on mammary blood flow.


Site of gene action in steel mice: analysis of the pigment defect by mesoderm-ectoderm recombinations.


Books as clinical tools. Annotated book list for practicing physicians (1973).


Selection of a major connector for the extension-base removable partial denture.


A classification of articulators.

A classification of articulators.


Periodontal considerations for prosthetic patients.


Measurement of the area of the maxillary basal seat for dentures.


Porcelain fused to metal: tooth preparation and coping design.


Orthodontics for restorative procedures.


An evaluation of induced extrusion in the repair of a loose tooth.


Temporomandibular joint syndrome: influence of the first symptom on the initial therapeutic response.


The loose terminal abutment retainer.

The loose terminal abutment retainer.


Accurate adaptation of the porcelain pontic to the edentulous ridge section of the cast.


Experience. (William Guy).

Experience. (William Guy).


Guy's Hospital and medical school, London.


Bronchopulmonary dysplasia--what is it?

Bronchopulmonary dysplasia--what is it?


An evaluation of the application of computer technology to medical education.


Safe combined general and topical anesthesia for laryngoscopy and bronchoscopy.


Rete vasculosum of the anterior part of the knee joint.


Standards of eyeglasses.

Standards of eyeglasses.


Disk disease and occult malignancies.

Disk disease and occult malignancies.


Lymphocyte size distribution. Determination in normal children and adults and in patients with immunodeficiency states.


Intracerebral pulmonary venous drainage.


Titrimetric determination of amphetamine sulphate in tablets.


Exstrophy of the cloaca.

Exstrophy of the cloaca.


Use of continuous positive airway pressure in the improved postoperative management of neonatal respiratory emergencies.


Empyema after pneumonectomy.

Empyema after pneumonectomy.


Systemic mycoses--primary pathogenic fungi.


A new universal stereoencephalotome (model 6).


Cortical projections of Nucleus ventralis lateralis in man.


Computer-aided localization techniques for stereotaxic surgery.


An integrated system for brain stimulation and lesion production in human stereotaxic surgery.


Stereotactic evaluation of bitemporal epilepsy with electrodes and lesions.


University of Tennessee College of Dentistry.


Temporomandibular joint surgery. Correction of pain, tinnitus, and vertigo.


Human pituitary follicle stimulating (FSH) and luteinizing (LH) hormones: current status.


Substructure of paramyosin filaments prepared by freeze-substitution technique.


Therapeutic and immunologic effects of iodoacetate in mature AKR mice.


Interpersonal relations among psychiatric patients: the determinants of social attractiveness.


Class, ethnicity, and race in American mental hospitals, 1830-75.


Harvey's doctrine of the circulation of the blood in seventeenth-century Spain.


Disease and the Freedmen in Missippi during reconstruction.


A confrontation over clinical instruction at the Hôtel-Dieu of Paris during the French Revolution.


A medley-credulity, superstition, and fanaticism (1762), engraved by William Hogarth (1697-1764).


History of the word 'antibiotic'.

History of the word 'antibiotic'.


The bactericidal action of immunoglobulin A.


In-vivo and in-vitro studies of the effect of specific antitoxin on the phagocytosis of cells of Clostridium botulinum type A.


Alimentary mycotic lesions in cattle: a histological and cultural study.


Effect of co-trimoxazole on faecal enterobacteria: no emergence of resistant strains.


Hugh Bethune Maitland: 15 March 1895-13 January 1972.


Use of the serum-opacity reaction in the typing of group-A streptococci.


The K88 antigen of Escherichia coli--a model for vaccination with a virulence factor?


The effect of antibiotics upon R-factor transfer between strains of Escherichia coli in the human gastro-intestinal tract.


"Lost in transit": inactivation studies with anaerobes on swabs and plates.


Lactic dehydrogenase (LDH) virus and its localisation by immunofluorescence.


Incidence and characteristics of Streptococcus pyogenes resistant to lincomycin and erythromycin.


Bacteriophage tail components. IV. Pteroyl polyglutamate synthesis in T4D-infected Escherichia coli B. The nature of pteroyl polyglutamates in uninfected and T4D bacteriophage-infected Escherichia coli B has been examined. (3)H-p-aminobenzoic acid has been used to label the folate compounds and gel permeation chromatography on glass beads to separate the folate compound by molecular size. It has been found that, although the major folate compound in uninfected bacteria is pteroyl triglutamate, E. coli B cells also contain folate compounds having as many as six glutamate residues. Infection with T4D stimulated the addition of glutamate residues to the lower-molecular-weight host pteroyl compounds, resulting in the conversion of the host compounds into the hexaglutamate form. This viral-induced conversion is chloramphenicol sensitive and appears to be due to a late phage gene product. The phage gene responsible for this conversion has not been identified. In cells infected with a T4D mutant defective in gene 28, there was an apparent production of the large pteroyl polyglutamates equivalent in size to pte(glu)(9-12). These high-molecular-weight forms were converted into pte(glu)(6) by incubation with bacterial extracts made after infection with T4D 28(+). Apparently, the product of T4D gene 28(+) is capable of specifically cleaving the high-molecular-weight polyglutamates to the form necessary for phage tail assembly.


Bacteriophage tail components. V. Complementation of T4D gene 28 - -infected bacterial extracts with pteroyl hexaglutamate. Synthetic pteroyl hexaglutamate (9 x 10(-6) M) stimulated the formation of new T4D particles in vitro in extracts of Escherichia coli B infected with T4D gene 28(-). The stimulation was specific for this form of folic acid since neither pteroyl pentaglutamate nor pteroyl heptaglutamate stimulated phage formation. T4D formation in vitro in E. coli B extracts prepared after infection with 11 other phage mutants known to be involved in phage tail plate formation (5(-), 6(-), 7(-), 8(-), 10(-), 25(-), 26(-), 27(-), 29(-), 51(-), 53(-)) was not stimulated by the addition of pteroyl hexaglutamate. It can be concluded that the T4D gene 28 product is involved in the formation of the phage tail plate pteroyl hexaglutamate.


Mechanism of adsorption and eclipse of bacteriophage phi X174. II. Attachment and eclipse with isolated Escherichia coli cell wall lipopolysaccharide. A mixture of aqueous phenol, choloroform, and ether extracts the lipopolysaccharides (LPS) from the phiX174-sensitive strain, Escherichia coli C/1, and resistant strains, C/phiX and K12. Interaction of the C/1 LPS with phiX in a starvation buffer containing 10(-3) M CaCl(2) at 37 C, but not at 15 C, results in a first-order inactivation that is specific for C/1 LPS. After interaction for 60 min at 15 C, followed by centrifugation, 37 and 20% of a (14)C-phiX preparation are bound to the C/1 and C/phiX LPS pellets, respectively. The results for intact cells are 75 and 10%. Supporting the conclusion that this represents specific attachment of phiX to its receptor site in the LPS is the fact that EDTA-borate buffer is required to elute 85% of the (14)C-phiX from the C/1 LPS, whereas starvation buffer elutes the same amount from C/phiX LPS. Moreover, 95% of the PFU are found in the C/1 LPS pellets as compared with 50% in the resistant strain LPS pellets. When the products of interaction between phiX and LPS at 37 C are examined by sucrose density gradients in EDTA-borate, a single 60 to 90S peak is observed in the C/1 sample, and the single peak cosediments with the 120S marker phiX in the C/phiX sample. This change in S(20, w) is very similar to that reported for the eclipse of phiX in vivo. If the inactivation at 37 C is carried out on phiX-LPS complexes first formed at 15 C, the first-order kinetics are biphasic and nearly identical to that observed for the eclipse kinetics of phiX attached to intact cells. Thus, the phiX-LPS system is suitable for in vitro studies on the early events in phiX infection.


Cadaverine in bacteriophage T4.

Cadaverine in bacteriophage T4. Cadaverine was found in bacteriophage T4 when the host cells of Escherichia coli K-12 were grown in complex media and aerated by agitation. Only traces of cadaverine were found if the host was grown and agitated in synthetic medium or was aerated by vigorous bubbling in a complex medium. When the host cells were grown anaerobically in a complex medium, cadaverine became the major polyamine in the progeny phage. The polyamine content comprised 80% cadaverine, 14% spermidine (or its recently discovered homologue, N-3-aminopropyl-1, 5-diaminopentane), and the remainder putrescine. The conditions that favored appearance of cadaverine are known to be required for induction of lysine decarboxylase. It was shown that lysine was the sole source of bacterial cadaverine.


Genetic and immunological studies of bacteriophage T4 thymidylate synthetase. Thymidylate synthetase, which appears after infection of Escherichia coli with bacteriophage T4, has been partially purified. The phage enzyme is immunologically distinct from the host enzyme and has a molecular weight of 50,000 in comparison to 68,000 for the host enzyme. A system has been developed to characterize T4 td mutants previously known to have impaired expression of phage thymidylate synthetase. For this system, an E. coli host lacking thymidylate synthetase was isolated. Known genetic suppressors were transduced into this host. The resulting isogenic hosts were infected with phage T4 td mutants. The specific activities and amounts of cross-reacting material induced by several different types of phage mutants under conditions of suppression or non-suppression have been examined. The results show that the phage carries the structural gene specifying the thymidylate synthetase which appears after phage infection, and that the combination of plaque morphology, enzyme activity assays, and an assay for immunologically cross-reacting material provides a means for identifying true amber mutants of the phage gene.


Analysis of nuclear disruption and binding of intermediates in host DNA breakdown to membranes after infection of Escherichia coli with bacteriophages T4 and T7. Escherichia coli DNA polymerase I is implicated in the binding of intermediates in host DNA breakdown to membrane in T4-infected, but not T7-infected, cells. Nuclear disruption is observed in T4-infected polA1 mutant cells.


Chromosome replication, transcription and control of cell division in Escherichia coli.


Evidence of "three point" attachment of tRNA to methionyl tRNA synthetase.


Leukocyte response to muscle antigens in myasthenia gravis. Relationship to clinical severity and presence of circulating antibodies.


Combined sonographic and biochemical estimation of fetal maturity in high-risk pregnancy.


Pituitary response to synthetic LH-RH in Stein-Leventhal syndrome and functional amenorrhea.


Intrauterine lavage for control of uterine atony.


Effects of hippocampal lesions on passive avoidance and taste aversion conditioning.


Lesions of pontine and medullary reticular formation and prestimulus inhibition of the acoustic startle reaction in rats.


Effects of subcortical ablations on cortical association responses in the cat.


Factors influencing the lesioning effect of gold thioglucose on the ventromedial hypothalamus of Bar Harbor obese mice.


Hypothalamic obesity following knife cuts that minimize arterial damage.


General activity in intact and hypophysectomized rats after administration of melanocyte-stimulating hormone (MSH), melatonin, and PRO-LEU-GLY-NH 2 .


Reaction to electrical shock after cerebellar lesions in the rat.


Ventral midbrain involvement in copulatory behavior of the male rat.


Differential effects of hypothalamic transections on the wood gnawing behavior of rats.


Taste preferences for sucrose solutions and water under cholinergic and deprivation thirst.


Electrical brain stimulation as a Pavlovian conditioned inhibitor.


A variable inclined plane for blocking the rat's brain.


Water and nonelectrolytes permeability in mammalian red cell membranes.


Structure and strategy in phage RNA.

Structure and strategy in phage RNA.


Divalent cations as charge carriers in excitable membranes.


Pathophysiologic roles of prostaglandins and the action of aspirin-like drugs.


Clinical trials with antithrombotic and thrombolytic agents. Principles and pitfalls.


A study of toxoplasma infections in cats as detected by the indirect fluorescent antibody method.


How impervious is the placental barrier?


Most common errors leading to faulty conclusions in a clinical laboratory.


Requirements and problems in urinalysis for abuse drugs: the role of gas chromatography.


Vascular hemostasis: a review.

Vascular hemostasis: a review.


To the editor: culture of urine in thio for anaerobes.


A modern approach for drug identification.


Problems in the diagnosis of malignant melanomas of the choroid and ciliary body. The 1972 Arthur J. Bedell Lecture.


Choroidal folds. The seventh Harry Searls Gradle Memorial lecture.


Repair of the ureter severed at operation.


Prevention of postoperative hemorrhage after pancreatic cystogastrostomy.


Open pilot trial of pimozide in patients suffering from psychic stress.


Study of intracellular distribution of medicinal and toxic substances by means of fluorescent antibody method.


The activity of K + -activated yeast aldehyde dehydrogenase following rapid changes in cation environment.


Characterization of the aspartate carbamoyltransferase subunit obtained from a multienzyme aggregate in the pyrimidine pathway of yeast. Activity and physical properties.


Penicillin in the treatment of syphilis. The experience of three decades.


Pediatric interviewing technics.

Pediatric interviewing technics.


Antimalarial activity of racemic 3-epidihydroquinine, 3-epidihydroquinidine and their various racemic analogs in mice infected with Plasmodium berghei.


Wladyslaw Szafer, 1883-1970.

Wladyslaw Szafer, 1883-1970.


Bogumil Pawlowski, 1898-1971.

Bogumil Pawlowski, 1898-1971.


Chromatographic characterization of antitumor lipids from a group A Streptococcus.


Estimation of circulating blood volume from a tracer-response curve.


Leucocyte migration inhibition in thyroid disease. Effect of human thyroid microsomes and thyroglobulin.


Papaverine--safety in use.

Papaverine--safety in use.


Antiviral drugs in Jakob-Creutzfeldt disease.


Dr. Grainger appointed editor of CDA Journal.


Waveform vector analysis of orthogonal electrocardiograms: quantification and data reduction.


Automatic ECG and arrhythmia interpreter--an almost analog device.


1973 yearbook: the Journal of the Indiana State Medical Association.


An ECG Compression Code.

An ECG Compression Code.


Frank Solomon Hansman.

Frank Solomon Hansman.


Harry Glennie Holmes.

Harry Glennie Holmes.


Observer variation in clinical diagnosis--a computer-aided assessment of its magnitude and importance in 552 patients with abdominal pain.


Discriminant and Bayes analysis in the differential diagnosis of Crohns disease and proctocolitis.


Performance and applications of the Toulouse 3 million volt electron microscope.


Tri-dimensional structure of the forming face of the Golgi apparatus as seen in the high voltage electron microscope after osmium impregnation of the small nerve cells in the semilunar ganglion of the trigeminal nerve.


Pathogenicity in mice of strains of Candida albicans (Robin) Berk. isolated from burn patients.


Liver disease in hog caused by Rhizopus cohnii.


Heterozygous diploid strains of Aspergillus nidulans: enhanced virulence for mice in comparison to a prototrophic haploid strain.


The cellular basis of metabolic bone disease.


Survival of patients on hemodialysis.

Survival of patients on hemodialysis.


Coagulopathy syndrome due to streptococci.


Changes in serum luteinizing hormone folowing intraventricular and intravenous injections of luteinizing hormone-releasing hormone in the rat.


The effect of treatment with prednisone and nitrogen mustard on the renal lesions and life span of patients with lupus glomerulonephritis.


Oxygen chemoreceptors in low birth weight infants.


Obituary. Prof. N. P. Buu-Hoi--1915-1972. Scientific director of C.N.R.S.


Lesions in the amygdala and the frustration effect.


Effects of chemical stimulation of the hypothalamus upon gastric secretion.


Hypothalamic metallic deposition and the production of experimental obesity.


Interaction of hypothalamic structures in the mediation of male sexual behavior.


Neuroanatomical localization of memory disruption: relationship between brain structure and learning task.


Delayed response in cats after frontal lesions extending beyond the gyrus proreus.


Effectiveness of lateral hypothalamic stimulation, arousal, and food deprivation in the initiation of hoarding behaviour in naive rats.


Effects of cortical spreading depression on behaviors elicited by hypothalamic stimulation in rats.


A retracting wire knife for stereotaxic brain surgery made from a microliter syringe.


Long-term maintenance of normal human skin on congenitally athymic (nude) mice.


Osteogenic potential of leukemic marrow.


Enzymatic synthesis of prolactin-releasing factor (PRF) by rat hypothalamic incubates and by extracts of rat hypothalamic tissue: evidence for "PRF synthetase".


Interaction between Salmonella enteritidis and Candida albicans.


William Vaughn Banning, M.D. 1906-1972.

William Vaughn Banning, M.D. 1906-1972.


Stamps in radiology.

Stamps in radiology.


John S. Bouslog, M.D. 1890-1973.

John S. Bouslog, M.D. 1890-1973.


Hypotonic duodenography with glucagon.

Hypotonic duodenography with glucagon.


The odontological identification of Adolf Hitler. Definitive documentation by x-rays, interrogations and autopsy findings.


Subcutaneous abscess caused by Phoma sp. resembling Pyrenochaeta romeroi: unique fungal infection occurring in immunosuppressed recipient of renal allograft.


Review of glucose tolerance--a problem in methodology.


The relationship of congenital toxoplasmosis to retrolental fibroplasia.


Yeast inorganic pyrophosphatase. IV. Purification, quaternary structure, and evidence for strongly bound Mg 2+1 .


The in vitro synthesis of T2 bacteriophage-induced deoxycytidylate deaminase and its regulation by allosteric effectors.


Homocitrate synthase from yeast.

Homocitrate synthase from yeast.


The primary structure of ovine interstitial cell-stimulating hormone. II. The  -subunit.


Control of lysine biosynthesis in yeast.


Glutamate decarboxylase: inhibition by monocarboxylic acids.


On the mechanism of glycogen phosphorylase.


Isolation of isoaccepting tRNAs.

Isolation of isoaccepting tRNAs.


Binding of N-acyl derivatives of phenylalanyl-tRNA to the 30S ribosomal subunit.


Translational initiation: defects arising in Escherichia coli infected with phage T7,  , and Q .


Isolation and characterization of   2 -microglobulin from urine of kidney transplant and multiple myeloma patients.


Spontaneous loss of axons in sympathetic unmyelinated nerve fibers of the rat during development.


Reversible heat injury in the marine psychrophilic bacterium Vibrio marinus MP-1.


Physiological changes following the breaking of dormancy of Saccharomyces cerevisiae ascospores.


Marine basidiomycetous yeasts (Rhodosporidium spp. n.) with tetrapolar and multiple allelic bipolar mating systems.


Effect of endotoxin administration on the growth of Candida albicans in sera from various species.


Spheroplast formation by an anaerobic gram-negative bacterium Bacteroides ruminicola.


Rural health services in independent India.


Tissue antigens excreted in the urine under normal and pathological conditions.


An ultrastructural analysis of the photoreceptors of the squid and their synaptic connections. I. Photoreceptive and non-synaptic regions of the retina.


Neutralization reaction of bacteriolysins and its application for the titration of salmonella O antigens.


Intergroup phage reactions and transduction between group C and group A streptococci. In a study of intergroup reactions, four virulent Group A streptococcal phages were found to form plaques in high titer on lawns prepared from a number of Group C streptococcal strains. Whether the phages were propagated on the homologous (Group A) strain or a heterologous (Group C) strain did not appear to influence consistently the plaque-forming efficiency on lawns prepared from a homologous (Group A) or a heterologous (Group C) strain or to alter significantly the percent of Group C strains which showed plaque formation. Considerable variability was found in the ability of temperate phages to lyse strains of a heterologous group. A single Group C indicator strain was lysed by a high percentage of freshly induced temperate Group A phages. A single temperate Group C phage lysed a significant proportion of Group A strains when freshly induced or when propagated on a Group A strain. Intragroup transduction of streptomycin resistance was demonstrated between Group C strains. Intergroup transduction of streptomycin resistance and also bacitracin resistance was achieved between Group C and Group A streptococci. These observations provide evidence that Group A streptococci can serve as recipients in intergroup transmission of genetic information. Ultraviolet irradiation of the transducing lysate and lowering the propagation temperature of the transducing lysate increased the frequency of transduction in both the intragroup and intergroup transduction systems.


The agglutinating and immunofluorescent antibodies of antileptospiral rabbit sera.


On the formation of dental plaques.

On the formation of dental plaques.


Effect of topical vancomycin on plaque and chronic gingival inflammation.


Pathology of liver necrosis and regeneration after administration of dimethylnitrosamine in massive doses.


Tissue reaction to intracavitary electrodes: effect on duration and efficiency of unipolar pacing in patients with A-V block.


Technique of insertion of pacing electrode through the internal jugular vein.


Acute adenopathy in a young man.

Acute adenopathy in a young man.


G. Armauer Hansen.

G. Armauer Hansen.


Transcription of a bacteriophage DNA by mammalian RNA polymerase.


Play: a nursing diagnostic tool.

Play: a nursing diagnostic tool.


Contributions of Maryland physicians to medical journalism in the United States.


Survey of chemical and related weapons of war.


The effects of ahemeral light and dark cycles on egg production in the fowl.


Susceptibility of mammalian (Hamster) cell culture to infection with type II leukosis virus (JM).


Effect of feed medicaments on bacterial infections in ducklings.


Salmonella in the laying hen. 1. Salmonella recovery from viscera, feces and eggs following oral inoculation.


Endosteal implants. Indications and contraindications for their use in general practice.


Effect of intravenously administered strychnine on the EEG recorded from the deep structure of the adult chicken telencephalon.


Continuous practice analysis without a computer.


Team work and clinical research in the treatment of cleft lip and palate.


Studies of gingival conditions in relation to orthodontic treatment. I. The relationship between amounts of gingival exudate and gingival scores, plaque scores and gingival pocket depths in children undergoing orthodontic treatment.


Apernyl as alveolar inlay in connection with the removal of impacted third molars of the lower jaw. A clinical double blind investigation of 100 patients.


Laboratory diagnosis of transmissible gastroenteritis by immunofluorescence.


International public health: some reflections after 25 years.


Obstetrics and gynecology as a career choice. Presidential address.


In vitro studies of human tumor and embryonic tissue.


Equal sensitivity of the two strands of phiX174 replicative DNA to breakage by ionizing radiation. The supertwisted, double-stranded, replicative intermediate of øX174 DNA (RFI) has been used to determine whether one of the two strands of the double helix is uniquely sensitive to induction of single-strand breaks by ionizing radiation. This could result from a particularly sensitive base sequence or a transfer of energy to a specific location of the DNA molecule. The results indicate that both strands of the double helix are equally broken, even though their base compositions are significantly different. If there are "hot spots" in the strands, then they are present in equal amounts in each strand.


Computers and cardiovascular medicine.

Computers and cardiovascular medicine.


Pathogenetic mechanisms in dengue haemorrhagic fever: report of an international collaborative study. In a study of 55 persons with dengue haemorrhagic fever-36 of whom showed the dengue shock syndrome-clinical, haematological, virological, and serological changes were correlated with serial measurements of complement components and immunopathological studies. Viruses dengue-1 or dengue-2 were isolated from the sera of 9 patients. Serological responses indicative of secondary dengue virus infections were observed in 53 patients; 2 (infants) had primary infections. During the acute phase of the disease, dengue antibody titres rose logarithmically. Marked depression of complement components, especially C3, was observed. Activation of both the classical and alternative complement pathways was demonstrated, with depression of both C4 and C3 proactivator levels in most instances, although in some cases it appeared that one mechanism was involved to a greater extent than the other. The level of depression of C3 was correlated with the severity of the disease. Relatively stable transferrin levels indicated that depletion of complement proteins was not primarily due to extravasation. Fibrinogen levels were depressed and fibrinogen split products were found in the plasma. The accumulated data provide further evidence of the central role that activated complement components play in the pathogenesis of dengue haemorrhagic fever.


Clinical pathologic correlations in coronary artery disease.


Renal cortical blood flow, cortical fraction, and cortical blood volume in hypertensive subjects.


Poverty as a criterion of risk.

Poverty as a criterion of risk.


The role of unsuspected infection in the etiology of prematurity.


Anemia: a high-risk complication of pregnancy.


Radiation risk in pregnancy.

Radiation risk in pregnancy.


Estrogen assessments in the high-risk pregnancy.


Protein components of the haemolymph of triatomid bugs (Hemiptera: Reduviidae).


Diabetes in pregnancy.

Diabetes in pregnancy.


Amniotic fluid assays in high-risk pregnancy.


Assessment of the infant at risk.

Assessment of the infant at risk.


Who is the "risk infant"?

Who is the "risk infant"?


The properties of 3,4-methylenedioxyamphetamine (MDA). I. A review of the literature.


Presently recognized forms of inherited jaundice in infancy. A summary and review.


Transport of nucleosides in Trypanosoma lewisi.


Cell turnover following small bowel resection and by-pass.


Effect of dimethyl sulfoxide (DMSO) on gastric secretion in rats.


Scanning electron microscope observations of apical surfaces of dog thyroid cells.


Reactivation of progressive motility in hamster sperm modified by Triton X-100.


Distribution and shifts of ingested marker particles in residual bodies and other lysosomes. Studies on in vitro cultivated human glia cells in phase II and 3.


The effect of calcium ion concentration on myotube formation in vitro.


Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence.


Electrical excitability and chemosensitivity of mouse neuroblastoma X mouse or human fibroblast hybrids.


Cellular composition of fractions of mouse testis cells following velocity sedimentation separation.


Nuclear histones of unfertilized sea urchin eggs.


Some haematological and biochemical effects of a malaria control programme in New Guinea.


Further evidences in favour of multiplication of bacteriophage P22 in penicillin-induced spheroplasts of Salmonella typhimurium.


Incorporations of thymine and deoxythymidine into DNA of uninfected and bacteriophage P22-infected Salmonella typhimurium.


A dorsolateral muscle-separating approach for thoracolumbar intervertebral disk fenestration in the dog.


Multiple cases of feline leukemia and feline infectious peritonitis in a household.


Structure and polymorphism of light meromyosin aggregates.


Mitogenic activity of a sepharose-concanavalin A complex on rabbit spleen cells.


Keizo Kodama (1891-1972.

Keizo Kodama (1891-1972.


Quantitative electromyography--a method by computer analysis.


Recoveries and reproducibility in the thin-layer chromatographic fluorimetric determination of flavins by the elution method. 8. Chromatography of riboflavin decomposition products.


Step-change versus gradient lithium buffers for single-column chromatography of complex amino acid mixtures.


Thin-layer chromatography and enzyme inhibition techniques.


A bibliography of doctoral dissertations on aging from American institutions of higher learning, 1970-1972.


Cardiac performance in the unanesthetized senescent male rat.


Current publications in gerontology and geriatrics.


In vitro development of first-generation schizonts of Eimeria canadensis (Bruce, 1921).


The chin.

The chin.


A logical approach to diagnosis of RA.

A logical approach to diagnosis of RA.


A controlled multicenter trial of 2,3-dihydro-1-H-pyridino (2,3-b)(1,4)-thiazine-2-one in rheumatoid arthritis.


Determintion of dimensions and geometry in fixed specimens.


Treatment of acute schizophrenia with molindone.


Fixation of microvasculature for electron microscopy.


Dimensions and geometry of the microcirculation: introductory remarks.


Photosensor methods of flow measurement in the microcirculation.


The measurement of pressure and flow in the microcirculation.


Pyogenic hepatic abscess.

Pyogenic hepatic abscess.


Pathogenesis of cardiogenic shock. I.

Pathogenesis of cardiogenic shock. I.


Topical vancomycin as a deterrent to bacteremias following dental procedures.


Vitallium endodontic implants: a scanning electron microscope, electron microprobe, and histologic study.


Epilepsy.

Epilepsy.


The autonomic nervous system.

The autonomic nervous system.


Radiology of the skull and central nervous system.


Neuroanatomy.

Neuroanatomy.


Surgery of the spinal cord and spinal column.


Brain tumors.

Brain tumors.


Neurovascular disorders.

Neurovascular disorders.


Child psychiatry.

Child psychiatry.


Clinical psychiatry.

Clinical psychiatry.


Family therapy.

Family therapy.


Psychoanalysis.

Psychoanalysis.


Psychosomatic medicine.

Psychosomatic medicine.


Drug therapy.

Drug therapy.


Internal-external control, divergent thinking and levels of abstractness.


Parent-child similarity in choice of responses to frustrating situations.


Health care delivery and advanced technology. Remedying the deficiencies in the current health care delivery system and effectively using advances in biomedical research require that a significant effort be organized to develop advanced technology in this field. The time is ripe and development personnel are available; hence, what are needed are simply a dedication to solving the problem, a commitment of resources toward this end, and an organizational mode that will allow the effective participation of developmental personnel.


Berliner resigns from NIH.

Berliner resigns from NIH.


History of iodine prophylaxis with regard to cretinism and deaf-mutism.


Effects of hormones and nutrition on brain development.


Photographic self-image confrontation.

Photographic self-image confrontation.


Membrane D-lactate dehydrogenase from Escherichia coli. Purification and properties.


Malignant immunoblastoma: immunoglobulin synthesis and the progression to leukemia in heterotransplanted acute lymphoblastic leukemia, chronic lymphatic leukemia, lymphoma, and infectious mononucleosis.


Use of the cytocentrifuge in the diagnosis of meningeal leukemia.


Application of the phase partition method to a hydrophobic membrane protein, phospholipase A1 from Escherichia coli.


Improvements in the double impression technique.


Binding of oestradiol by the nuclear fraction of rat testis interstitial tissue.


Isolation of four ribonucleoprotein fragments from the 30 S subunit of E. coli ribosomes.


Stepwise phosphorolysis with polynucleotide phosphorylase: a novel method for sequence analysis of oligoribonucleotides.


Human sperm capacitation and in vitro fertilization.


Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia.


Different affinities of the  -and  -anomers of D-glucose, D-mannose and D-xylose for the glucose uptake system of baker's yeast.


Antimicrobial agents. XVII. Antimycotic activity of 2-aminotridecane addition salts.


DNA synthesis in a synchronized culture of Escherichia coli 15 TAU bar after continuous and interrupted thymine starvation.


The isolation and characterization of auzotrophs of the aspartic acid family from Streptomyces lipmanii.


The potentiality of EMMA-4, the analytical electron microscope, in histochemistry: a review.


Current aspects of tumor immunology. Preface and introduction.


Immunological aspects of resistance to the oncogenic effect of 3-methylcholanthrene in mice.


A new look at the cell surface.

A new look at the cell surface.


Changes in cell surface properties during the in vivo growth of Moloney lymphoma.


Cellular immunity to human tumor-associated antigens. A review.


Human breast cancer. A model for cancer immunology.


Intravenous diazepam in dentistry: operating conditions in a controlled clinical trial.


Heterogenization of normal tissues in oncogenesis. A skeptical review.


Frederich Bidder (1810-1894) and Carl Schmidt (1822-94)--a biographical sketch.


Repairing a bridge using threaded nonparallel pins.


Bone marrow grafting in the oral cavity of mice.


Atypical electron microscope structures in liver mitochondria.


Otolaryngological findings in patients with chronic respiratory paralysis after poliomyelitis.


Fungistatic activity, uptake and incorporation of 5-fluorocytosine in Candida albicans, as influenced by pyrimidines and purines. I. Reversal experiments.


Congenital cardiac anomalies in lead poisoning.


20th anniversary of the Czechoslovak Academy of Sciences.


The short-term measurement of plasma protein catabolic rates.


Ways of reducing atelectasis and improving oxygen uptake form the lungs.


Transtracheal ventilation during microsurgery of the larynx.


New drugs of 1972.

New drugs of 1972.


Persistent gram-negative bacteremia. Observations in twenty patients.


Split thickness porcine graft in the treatment of close-range shotgun wounds to extremities with vascular injury.


Surgical floatation retention button.

Surgical floatation retention button.


The rennin catalyzed hydrolysis of a tripeptide. Evidence for catalysis by two carboxyl groups.


Renal transplantation for the nail patella syndrome.


Relations between spermidine content and RNA stability in rifampicin treated Escherichia coli.


The uptake system of free thiamine in mutants of Escherichia coli.


Characteristics of N-Ac-Phe-tRNA binding and its correlation with internal aminoacyl-tRNA recognition.


Conversion of exposed aspartyl and glutamyl residues in proteins to asparaginyl and glutaminyl residues.


Cellular immunity in man assessed by indirect migration inhibition test using murine spleen leukocytes.


Appearance of actin in embryos of Rana temporaria studied by immunofluorescence.


Toxicity of dimethyl sulphoxide to plaque-forming cells.


Klebsiella in a thoracic ICU.

Klebsiella in a thoracic ICU.


A classification of patient-peer interaction.