Pathologic and bacteriologic features and hypersensitivity of pigs given Mycobacterium bovis, Mycobacterium avium, or group 3 Mycobacteria.


Serologic diagnosis of bovine tuberculosis.


Reentrant cannulation and postoperative therapy in cattle.


Actinomyces viscosus as an agent of actinomycosis in the dog.


Membranes of photosynthetic bacteria.

Membranes of photosynthetic bacteria.


Methods for the assay of ultraviolet light-induced pyrimidine dimers in Saccharomyces cerevisiae.


Substrate specificity of the three endonucleases isolated from phage lambda C 1 -infected Escherichia coli.


A modified mouse liver chromatin preparation displaying age-related differences in salt dissociation and template ability.


Low molecular weight RNAs of post-ribosomal particles. Evidence that the particulate 4-S RNAs comprise a differential population of tansfer RNA.


Circular, repetitive DNA in yeast.

Circular, repetitive DNA in yeast.


In-vivo cytogenetic effects of perphenazine and chlorpromazine: a negative study. No evidence was found that either perphenazine or chlorpromazine induced chromosomal damage in patients given the drugs. These results were reached independently at two separate laboratories; earlier reports of possible adverse cytogenetic effects of these drugs can probably be discounted.


Problems with asthma.

Problems with asthma.


Medical teaching in St. Andrews University 1413-1972.


Clinical evaluation of co-trimoxazole and furazolidone in treatment of shigellosis in children. Co-trimoxazole (trimethoprim-sulphamethoxazole) was compared with furazolidone in the treatment of shigellosis in two groups of 33 and 30 patients respectively. Those treated with co-trimoxazole recovered more quickly; none had shigellae in the faeces four days after the start of treatment, whereas in the group given furazolidone eight still had positive stool cultures seven days after treatment.The susceptibility of 104 shigella strains to seven antimicrobial agents was studied by plate dilution technique. All agents but tetracycline and chloramphenicol were found highly effective against most of the strains tested. All shigella isolates were resistant to sulphamethoxazole, and 63% were sensitive to trimethoprim. Potentiation of trimethoprim by sulphamethoxazole was shown in that all strains tested became sensitive to the combination of trimethoprim and sulphamethoxazole in a ratio of 1:20.


Skin trauma and corticosteroids.

Skin trauma and corticosteroids.


Burst abdomen.

Burst abdomen.


Mycophenolic acid (NSC-129185): preliminary clinical trials.


Influence of the pH on production and stability of staphylococcal lysins.


Our experience with the application of FTA-ABS test for the determination of false-positive reactions in the serodiagnosis of syphilis.


Graphic stereo-reconstruction of serial sections.


A computer technique for the estimation of the absolute three-dimensional array of basal dendritic fields using data from projected histological sections.


Abnormalities of the teeth and their supporting structures.


Nodal metastases and prognosis in carcinoma of the oral cavity.


Bone grafts and bone implants.

Bone grafts and bone implants.


Fasting in the treatment of obesity.

Fasting in the treatment of obesity.


The chemical synthesis and the biochemical properties of peptidyl-tRNA.


Ultraviolet photochemistry as a probe of polyribonucleotide conformation.


Some recent developments in DNA enzymology.


Minor components in transfer RNA: their characterization, location, and function.


Shigellosis in custodial institutions. II. Clinical, immunologic and bacteriologic response of institutionalized children to oral attenuated shigella vaccines.


Shigella sonnei outbreak on the island of Maui.


Georgii Frantsevich Debets (1905-1969).

Georgii Frantsevich Debets (1905-1969).


Pre-cancer and the skin.

Pre-cancer and the skin.


Ureteric implantation in renal transplantation. A technical modification.


Urinary fistula from segmental infarction in a transplanted kidney: recovery following surgical repair.


Intestinal conduit urinary diversion in children.


The relationship between bacterial cultures of the vaginal introitus and urinary infection.


Streptococcal sore throat.

Streptococcal sore throat.


Conquest of general paralysis.

Conquest of general paralysis.


Malignant lymphomas of Waldeyer's ring: natural history and survival after radiotherapy. The natural history of 292 consecutive cases of reticulum cell sarcoma and lymphosarcoma of Waldeyer's ring and the survival rate after radiotherapy are reported. In our institute since 1928 from 30 to 35% of pharyngeal neoplasms have been lymphomas, and of these 55% have been reticulum cell sarcomas, 21% lymphosarcomas, and 1% Hodgkin's disease. This high incidence may probably be ascribed to the fact that in all malignant lymphomas, irrespective of the clinical presentation, a systematic biopsy of the whole Waldeyer's ring was carried out. Pharyngeal lymphomas were confined to Waldeyer's ring in 19.6% of cases, with initial spread to contiguous cervical nodes in 43.8%, to distant nodes in 24.2%, and to extranodal tissues in 12.4%. Lymphography showed abnormal retroperitoneal lymph nodes in 38.3% of cases. There was gastrointestinal involvement either initially or later in 17.6% of cases. High-energy radiation therapy to both sides of the neck was the treatment of choice for local and regional disease. It achieved a five-year survival rate of 41.9% in the group of 97 patients treated during the past decade. The incidence of relapse (recurrence and new manifestations) was highest in the first year after treatment.


Problems with asthma.

Problems with asthma.


Joseph T. Beardwood, Jr. (1896-1970).

Joseph T. Beardwood, Jr. (1896-1970).


Subunit structure of L-lactate dehydrogenase (cytochrome b2) of Saccharomyces cerevisiae. Ultracentrifugation studies.


Precipitation of lipopolysaccharides from rough mutants of Salmonella typhimurium by an A-hemagglutinin from Helix pomatia.


The role of ribosomal conformation in protein biosynthesis. Further studies with streptomycin.


The effect of magnesium-ion concentration on the translation of phage-f2 RNA in a cell-free system of Escherichia coli.


The early region of the DNA of bacteriophage T7.


Serum lipids in leprosy.

Serum lipids in leprosy.


Bicentenary of a dental classic: John Hunter's "Natural History of The Human Teeth".


Effects of synthetic luteinizing hormone-releasing hormone-follicle stimulating hormone-releasing hormone (LH-RH-FSH-RH) on serum LH, serum FSH and ovulation in anestrous ewes.


Hemopoietic colony studies. VI. Increased eosinophil-containing colonies obtained by antigen pre-treatment of irradiated mice reconstituted with bone marrow cells.


Determination of the glutaminase activity of asparaginase.


The search for therapeutic cell controls by the chemotherapy program of the National Cancer Institute.


Antibacterial activity in urine.

Antibacterial activity in urine.


Eric Francis Langley.

Eric Francis Langley.


Effect of tropical sunlight on development of rodent and squamous cell carcinoma.


Eric Roderick Watkins.

Eric Roderick Watkins.


Marie Eleanor Hill.

Marie Eleanor Hill.


Respiratory care of newborn infants.

Respiratory care of newborn infants.


Comparative oncology: dogs, cats, and man.


Androgen therapy.

Androgen therapy.


Genes which increase chromosomal instability in somatic cells and predispose to cancer.


Recent advances in plastic surgery.

Recent advances in plastic surgery.


Acid-base balance.

Acid-base balance.


"Some autummal gleanings".

"Some autummal gleanings".


Memorial. Hugh Edmund Burke.

Memorial. Hugh Edmund Burke.


Memorial. Oswald R. Jones, M.D.

Memorial. Oswald R. Jones, M.D.


Officers and members of the American Clinical and Climatological Association.


Memorial. William Sharp McCann, M.D.

Memorial. William Sharp McCann, M.D.


Memorial. William Atmar Smith, M.D. (1886-1971).


Studies on the pathogenesis of cholera.

Studies on the pathogenesis of cholera.


Memorial. John R. Paul, M.D.

Memorial. John R. Paul, M.D.


Memorial. Truman Gross Schnabel, Sr., M.D. (1886-1971).


Memorial. William Bowen Sherman, M.D. (1907-1971).


Memorial. Howard Burnham Sprague, M.D.

Memorial. Howard Burnham Sprague, M.D.


Memorial. Edwin Allen Locke, M.D.

Memorial. Edwin Allen Locke, M.D.


Memorial. Ralph Hermon Major, M.D.

Memorial. Ralph Hermon Major, M.D.


Memorial. Edward Leroy Bortz, M.D.

Memorial. Edward Leroy Bortz, M.D.


Memorial. John N. Hayes, M.D.

Memorial. John N. Hayes, M.D.


Memorial. Yale Kneeland, Jr., M.D.

Memorial. Yale Kneeland, Jr., M.D.


Memorial. Leo Williams Bortree, M.D.

Memorial. Leo Williams Bortree, M.D.


Preliminary clinical experience with L-dopa in endogenous depressions.


Side effects of lithium administration.

Side effects of lithium administration.


Hypoxia and some therapeutic problems in gerontopsychiatry.


The influence of diazepam and allobarbital on consolidation phase of memory in mental patients.


A comparison of pimozide with perphenazine in the treatment of acute schizophrenic psychoses.


Comparative studies on the proteolysis of fixed gelatin membranes by mammalian sperm acrosomes.


Observations on the cutaneous reactions to cholera toxin in suckling and adult animals.


Triploidy (69,XXY) in a liveborn infant.


Wakeley--the anatomist.

Wakeley--the anatomist.


Wakeley and cancer research.

Wakeley and cancer research.


And one man in his time (Cecil Wakeley).


Wakeley--president of the college.

Wakeley--president of the college.


The surgeon and international amity (Cecil Wakeley).


Wakeley--helper to the young surgeon.

Wakeley--helper to the young surgeon.


Sir Cecil Wakeley--surgeon.

Sir Cecil Wakeley--surgeon.


Home is where one starts (Cecil Wakeley).


Wakeley--the King's man.

Wakeley--the King's man.


Wakeley--the naval man.

Wakeley--the naval man.


Wakeley--the international surgeon in the Commonwealth.


Publications (Cecil Wakeley).

Publications (Cecil Wakeley).


Statistical analysis of symptoms for the differential diagnosis of goiters.


Esophagogastrectomy. Superiority of the combined abdominal-right thoracic approach (Lewis operation).


Cardiac valve replacement with Wada-Cutter prosthesis.


The pericardium.

The pericardium.


Dmitri Iosifovich Ivanovski (1864-1920).


Microbial co-metabolism and the degradation of organic compounds in nature.


Genetic structure and evolution of the incompatibility factors in higher fungi.


An investigation of the decoding of triplets adjacent to AUG during initiation.


Intramolecular heterogeneity of yeast mitochondrial DNA.


Primary sequence of arginine transfer RNA from Escherichia coli.


Purification of the membrane-bound and pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase from Escherichia coli.


The isolation and characterization of monopyrroles from Serratia marcescens.


Dinitrogen (N 2 ) fixation (with a biochemical emphasis).


The use of formamide gradients to distinguish between alkali labile regions and single strand breaks in DNA.


Secondary structure of the lac repressor.


Conformational change of the lac repressor induced with the inducer.


Non-invasive assessment of prosthetic mitral paravalvular and intravalvular regurgitation.


Papillary muscle dysfunction due to non-penetrating chest trauma. Recognition in a potential cardiac donor.


Immunological features in a case of chronic granulomatous candidiasis and its treatment with transfer factor.


An in vitro study of renal allograft recipients for cellular delayed type hypersensitivity to glomerular basement membrane and disrupted spleen cells.


The influence of local infection on immunoglobulin formation in the human endocervix.


Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA).


The relation of deoxyribonuclease inhibitor levels to the occurrence of antinuclear antibodies in NZB-NZW mice.


Chromosome banding with trypsin.

Chromosome banding with trypsin.


Primary application of the one stage abdominal tubed pedicle.


The mitochondrial genome of wild-type yeast cells. I. Preparation and heterogeneity of mitochondrial DNA.


The mitochondrial genome of wild-type yeast cells. II. Investigations on the compositional heterogeneity of mitochondrial DNA.


The mitochondrial genome of wild-type yeast cells. 3. The pyrimidine tracts of mitochondrial DNA.


Mechanism of post-irradiation degradation of deoxyribonucleic acid in a radiosensitive Escherichia coli (NG30) irradiated with ultraviolet light.


Temperature sensitive mutations affecting ribosome synthesis in Saccharomyces cerevisiae.


Ribosomal RNA synthesis in Saccharomyces cerevisiae.


Mutagenic effects of thymine dimers in bacteriophage T4.


Equilibrium and kinetic studies of Escherichia coli lac repressor-inducer interactions.


Biogenesis of mitochondria. XXI. Studies on the nature of the mitochondrial genome in yeast: the degenerative effects of ethidium bromide on mitochondrial genetic information in a respiratory competent strain.


Incorporation of deoxyribonucleoside diphosphates into DNA-like polydeoxyribonucleotides: experiments with an enzyme and toluene-treated cells from wild-type Escherichia coli.


Recombination in bacteriophage lambda DNA half molecules.


Triplet-state sensitization of thymine photodimerization in bacteriophage T4.


Contribution of thymine dimers to the ultraviolet light inactivation of mutants of bacteriophage T4.


Transfer RNA content of runoff and complexed ribosomes of Escherichia coli.


Surface topography of the 30 s Escherichia coli ribosomal subunit: reactivity towards fluorescein isothiocyanate.


Membrane phospholipids associated with nuclei and chromatin: melting profile, template activity and stability of chromatin.


Regulation of the carbamoylphosphate synthetase belonging to the arginine biosynthetic pathway of Saccharomyces cerevisiae.


Replicative intermediates of bacteriophage T7 deoxyribonucleic acid. After infection with bacteriophage T7, parental and newly synthesized deoxyribonucleic acid (DNA) exhibit an extremely fast sedimentation rate in neutral sucrose gradients. This fast-sedimenting component (intermediate I) has a sedimentation constant of about 1,500S and contains T7 DNA as determined by DNA-DNA hybridization experiments. Pulse-chase experiments indicate that the fast-sedimenting material is metabolically active and serves as a precursor to the formation of T7 DNA. Intermediate I contains about 2.5 to 7% of the total (3)H-labeled protein formed between 3 and 9.5 min after T7 infection. Treatment of intermediate I with Pronase results in the release of the DNA from the complex. At early times after infection, a second intermediate (intermediate II) can be detected which contains both parental and newly synthesized DNA sedimenting slower than intermediate I but 2 to 3 times as fast as mature T7 DNA. Intermediates I and II containing parental DNA are formed after infection of the nonpermissive host with an amber mutant in gene 1, a gene whose expression is necessary for the synthesis of most T7 proteins. The two intermediates are also observed when infection with T7 wild type is carried out in the presence of chloramphenicol.


Characterization of bacteriophage S13 suN15 single-strand and replicative-form deoxyribonucleic acid. The deoxyribonucleic acid (DNA) of bacteriophage S13 was shown to be single-stranded by the criteria of reactivity with formaldehyde, dependence of optical density on ionic strength, broad temperature-absorbance profile, and lack of molar equivalence of the purine and pyrimidine bases. The DNA has a molecular weight of 1.8 x 10(6) daltons, an S degrees (20) of 24.6 in SSC (0.15 m NaCl plus 0.015 m sodium citrate), and a buoyant density of 1.726 g/cc in CsCl. Electron microscopy showed the molecule to be circular. S13 replicative-form DNA was shown to be a double-stranded, circular molecule with a molecular weight of 3.5 x 10(6) daltons, an S([ill]) of 20.7 in SSC, and a buoyant density in CsCl of 1.710 g/cc. The finding that S13 DNA is slightly more pyrimidine-rich than phiX174 DNA but is indistinguishable by all other parameters supports the close genetic relationship between the two bacteriophages.


Host-virus interactions in Escherichia coli: effect of stationary phase on viral release from MS2-infected bacteria. Infection of stationary-phase Escherichia coli with MS2 bacteriophage results in the production, but not the release, of progeny virus by the host. Substantial protein synthesis in stationary-phase cells indicates that general protein synthesis is not sufficient to assure cell lysis or viral release.


Can job performance be predicted from biographical, personality, and administrative climate inventories?


Psychological differentiation in passively oriented children.


Projection of eyes in paranoid schizophrenia.


Quantifiable aspects of human figure drawings by male narcotics addicts: replications and extensions.


Development of motor impulse control and reflectivity.


Cancer and comparative pathology.

Cancer and comparative pathology.


Respiratory carcinogenesis studies with the Syrian golden hamster: a review.


Hormone-related tumors in Syrian hamsters.


Circulatory dynamics in heart failure of Syrian hamsters.


History and cytogenetics of hamsters.

History and cytogenetics of hamsters.


Dissecting aneurysms of the aorta, and pancreatic islet cell hyperplasia with diabetes in corticosteroid- and chlorothiazid- treated hamsters.


History and cytogenetics of hamsters. Excerpt from memoirs of a Hebrew zoologist (1942), Israel Aharoni.


Infection and immunity in hamsters.

Infection and immunity in hamsters.


Studies of cardiac allografts in Syrian hamsters.


Hamster cheek pouch chamber: homograft studies of normal and neoplastic tissues.


Pathologic lesions of GVH disease in hamsters: antigenic target versus 'innocent bystander'.


Experimental oral pathology in the Syrian hamster.


Transplanted tumours of the golden hamster (Mesocricetus auratus) used in research 1964-1970).


Total skin conservation approach to the surgery of the anorectal cryptoglandular intermuscular fistulous abscess and fistula with special reference to the "plastic saucerisation (marsupialisation) operation of the ischiorectal fossa".


A trial to compare reactions and responses to BCG vaccine prepared from Copenhagen 1331 and Glaxo 1077 strains.


A trial to compare United Kingdom strength BCG vaccine with vaccine of double the moist weight content.


The effect of adrenalectomy on the gastrointestinal tract. A review of the literature.


Bovine respiratory disease: is control possible?


Clarence Henry Graham: 1906-1971.

Clarence Henry Graham: 1906-1971.


Gösta Ekman: 1920-1971.

Gösta Ekman: 1920-1971.


Malnutrition, learning, and intelligence.


Herpes simplex encephalitis. The course in five virologically proven cases.


Diurnal variation of Candida albicans counts in saliva.


A trial of group psychotherapy for neurotics.


Professor Sir Martin Roth. A personal profile.


Relationship between serum lithium level and clinical response in acute mania treated with lithium.


Early history of psychiatry in Newcastle upon Tyne.


Paracelsus, 1493-1541.

Paracelsus, 1493-1541.


Acute infective gastroenteritis.

Acute infective gastroenteritis.


Clinical and laboratory findings in a trial of norgestrel, a low-dose progestogen-only contraceptive. Norgestrel, a progestogen-only oral contraceptive, was given continually at a dose of 75 mug/day to 144 women of proved fertility. It was an efficient contraceptive with a failure rate of 2.1% (assessed by the "life-table" method) within the first 12 cycles and 3.6% within the first 30 cycles (or 2.0 conceptions per 100 woman-years when assessed by the Pearl index). The overall conception rate for the entire trial period was 2.1% and 1.3 pregnancies per 100 woman-years respectively. Norgestrel caused a high proportion of irregular and generally short bleeding intervals, about one-fifth of the cycles lasting less than 17 days. This irregularity appeared to be due to individual variance in cycle length between women rather than that between their successive cycles. No confirmed instances of thromboembolism were observed. Norgestrel apparently exerts its contraceptive action by several mechanisms: reduction in the sperm penetrability of the cervical mucus and an impairment of luteal function appear important. The serum concentrations of cholesterol and globulin were significantly reduced in women taking norgestrel. Preliminary observations suggest that on discontinuing the medication fertility is promptly restored. Of the 144 women originally enrolled 57 (40%) withdrew for reasons connected with the method before completing 30 months on trial, over half of them because of the irregular menstrual pattern. Nonetheless, in view of its main clinical and laboratory characteristics and simple mode of administration, norgestrel appears to be a useful alternative to the combined type of pill for women unsuitable for, or unable to tolerate, oestrogen-containing preparations.


Respiratory resuscitation in ancient Hebrew sources.


Overproduction of hisH and hisF gene products leads to inhibition of cell cell division in Salmonella.


A three-year review of anesthesia for cataract extractions.


A useful memorial (Florence Nightingale).


Neonatal apnea associated with respiratory distress syndrome: a case report.


Pneumatosis cystoides intestinalis in acute leukemia.


Non-Hodgkin's lymphomas. II. Single agent chemotherapy.


How far do bacteria travel from the exhalation valve of IPPB equipment?


Serum bactericidal activity in patients with upper and lower urinary tract infections.


An antibactericidal factor in the serum of two patients with infections of the upper urinary tract.


Kinetics and mechanisms of action of trimethoprim and sulfonamides, alone or in combination, upon Escherichia coli.


Immunohistochemical and ultrastructural detection of the secretin cell in the pig intestinal mucosa.


Effects of 2-Br- -ergocryptine on plasma prolactin level and milk yield in cows.


The use of mitochondrial mutants of yeast in the screening for new antimetabolites.


Medicaid, past and future.

Medicaid, past and future.


Cell-mediated immune reactivity in liver disease. Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodies.Cell-mediated immunity to parotid extract was shown in 10 cases (28%). This is in accord with the occurrence of the sicca syndrome in liver disease, which has been confirmed in this study.


Clinical, microbiological, and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders. Seven patients with gastrointestinal disorders and deficiencies of serum and secretory immunoglobulins were evaluated clinically, microbiologically, and immunologically. Five patients had generalized deficiencies of immunoglobulins; two were selectively deficient. Diarrhoea and malabsorption in six of the seven patients were at least partially explained. Four of the five patients with generalized hypogammaglobulinaemia had intestinal infestation with Giardia lamblia; in three of the five, excessive numbers of anaerobic bacteria were cultured from small bowel fluids. Despite much variability in relative severity of patients' respiratory and gastrointestinal tract symptoms, deficiencies of mucosal immunocytes and immunoglobulins in nasopharyngeal and gastrointestinal tract tissues and secretions were similar. Except for one selectively IgA-deficient patient, all patients were deficient in IgE. The study characterizes in greater detail than heretofore the gastrointestinal disorders associated with immunoglobulin deficiency states.


Clinical trial of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A in the treatment of gastric ulcer. The effects of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A on the healing of gastric ulcer have been assessed in a multifactorial clinical trial conducted in out-patients treated for four weeks.Forty-eight patients completed the trial. Three groups of eight patients were given respectively 300, 600, and 1 200 mg of BX24 daily and were compared with 24 patients who were given 300 mg of carbenoxolone sodium daily. The size of the ulcer niche was reduced on average by 14.6% in the eight patients given BX24 300 mg daily, by 47.6% in the patients given 600 mg daily, and by 51.0% in the patients given 1 200 mg daily. In the patients given carbenoxolone the size of the niche was reduced by 68.9%. These results were compared with those obtained previously with carbenoxolone and inert tablets and it was concluded that BX24 is without clinically useful effect in the doses used. Eleven of the 24 patients (46%) treated with carbenoxolone sodium developed side effects due to fluid retention and electrolyte disturbances. None of the patients given BX24 experienced such effects. In addition to carbenoxolone or BX24, 24 patients were given zinc sulphate, 660 mg daily, and in 24 patients these tablets were withheld. Among the patients given carbenoxolone the reduction in the size of the niche was much the same irrespective of whether or not the patients received zinc sulphate. Among the 12 patients given BX24 with zinc sulphate the ulcer healed completely in four and, on average, the size of the niche was reduced by 53.5%, compared with 21.9% in the 12 patients given BX24 alone. This difference is not statistically significant but the possibility of a beneficial effect from zinc is not excluded. No side effects attributable to zinc were observed.Twenty-four patients were also given vitamin A, 50 000 units daily, and in 24 patients the vitamin was withheld. No evidence was obtained to suggest that vitamin A had any beneficial effect on the healing of gastric ulcer.


Bacterial agglutination studies with secretory IgA prepared from human gastrointestinal secretions and colostrum. The function of human purified colostral and gastrointestinal IgA has been studied by its ability to agglutinate common gastrointestinal organisms. Agglutinating activity was unaffected by trypsin or acid but it was abolished rapidly by pepsin. Both colostral and gastrointestinal IgA agglutinated a wide range of enteric organisms. Variations in this activity occurred between different individuals, and between different gastrointestinal sites in the same individual. In preliminary studies, saliva and IgA prepared from gastric and jejunal secretions in patients with pernicious anaemia showed a more uniform agglutination pattern than IgA prepared from the same sites in other patients. The agglutinin activity of IgA prepared from a particular site may be determined by the bacterial flora at that site. Agglutination methods for assessing the function of gastrointestinal antibody may be of value in the study of the possible roles of antibodies in inflammatory bowel disease.


Changes in the organization of tubulin during meiosis in the eggs of the surf clam, Spisula solidissima. Polymerized tubulin can be stabilized in Kane's spindle isolation medium (HGL solution), isolated by differential centrifugation and then assayed by colchicine binding activity. In the eggs of the surf clam, Spisula solidissima, the level of particulate tubulin undergoes a series of specific changes during first meiotic division. In either unactivated ("interphase") eggs or metaphase eggs the amount of particulate tubulin was about 13% of the total at 23 degrees C. The amount of particulate tubulin decreased shortly after activation, reaching a minimum value at about 5 min, the time of nuclear membrane breakdown. The particulate tubulin concentration then rose, reaching a maximum at metaphase, and then decreased again during anaphase, reaching a minimum at first polar body formation. In HGL homogenates of unactivated eggs a structure is present which has been shown to contain the interphase particulate tubulin (IPT). This structure consists essentially of a 10-20 micro granular sphere attached to a membranous material which is probably part of the egg cortex. These particles are absent at the time of nuclear membrane breakdown, when the level of particulate tubulin is minimal and when the first signs of spindle formation are visible. Electron microscopy of these particles by negative staining indicates that they are composed of microtubules associated with a granular matrix which may be a polymorphic aggregate of tubulin.


Pathogenesis of lethal influenza virus infection in turkeys. I. Extraneural phase of infection.


Biosynthesis in isolated Acetabularia chloroplasts. I. Protein amino acids. The ability of chloroplasts isolated from Acetabulana mediterranea to synthesize the protein amino acids has been investigated. When this chloroplast isolate was presented with (14)CO(2) for periods of 6-8 hr, tracer was found in essentially all amino acid species of their hydrolyzed protein Phenylalanine labeling was not detected, probably due to technical problems, and hydroxyproline labeling was not tested for The incorporation of (14)CO(2) into the amino acids is driven by light and, as indicated by the amount of radioactivity lost during ninhydrin decarboxylation on the chromatograms, the amino acids appear to be uniformly labeled. The amino acid labeling pattern of the isolate is similar to that found in plastids labeled with (14)CO(2) in vivo. The chloroplast isolate did not utilize detectable amounts of externally supplied amino acids in light or, with added adenosine triphosphate (ATP), in darkness. It is concluded that these chloroplasts are a tight cytoplasmic compartment that is independent in supplying the amino acids used for its own protein synthesis. These results are discussed in terms of the role of contaminants in the observed synthesis, the "normalcy" of Acetabularia chloroplasts, the synthetic pathways for amino acids in plastids, and the implications of these observations for cell compartmentation and chloroplast autonomy.


Pathogenesis of lethal influenza virus infection in turkeys. II. Central nervous system phase of infection.


Intranasal vaccination of cattle with an attenuated Gladysdale strain of Mycoplasma mycoides var. mycoides.


Hitler's lungs. 1945.

Hitler's lungs. 1945.


David Yi-Yung Hsia, M.D. (1925-1972.

David Yi-Yung Hsia, M.D. (1925-1972.


Pollicization.

Pollicization.


Bone growth.

Bone growth.


Lamellar structure of bleached and unbleached rod photoreceptor membranes.


Treatment of fruit with propylene gives information about the biogenesis of ethylene.


The visual system and "neuronal specificity".


G6PD expression and X chromosome late replication in fibroblast clones from a female mule.


Further proof of genetic inactivation of the X chromosome in the female mule.


Structural studies of calf thymus F3 histone. II. Occurrence of phosphoserine and  -N-acetyllysine in thermolysin peptides.


Increased hepatic microsomal enzyme activity from occupational exposure to certain organochlorine pesticides.


Criteria for the validation or invalidation of the competitive exclusion principle.


Potential use of nitrofurans in radiotherapy.


Coronary flow determination in experimental conditions with the use of radioactive Xenon ( 133 Xe).


Renal candidosis complicating caeco-cystoplasty. Case report with scanning electron microscopic studies.


Ureteric anastomoses in kidney transplantation. A comparison of results following uretero-pyelostomy and uretero-cystostomy.


Renal autotransplantation in the pig: surgical aspects.


Locomotion: energy cost of swimming, flying, and running.


Antilymphocyte globulin prepared by precipitation with Rivanol in the treatment of acute rejection following allogenic renal transplantation in the dog.


Lipid patterns of leukocytes in health and disease.


Biochemical and metabolic basis of familial sphingolipidoses.


The pathology of sphingolipidoses.

The pathology of sphingolipidoses.


A review of transmissible gastro-enteritis in England and a study of outbreaks in 1970-71.


Charges for care in nursing homes. United States--April-September 1968.


The discovery of librium.

The discovery of librium.


Testing of analgesics by electrical stimulation of the dental pulp in healthy volunteers (a modified test method).


Ancient descriptions of organic brain syndrome: the "Kordiakos" of the Talmud.


Scientific autographs. 8.

Scientific autographs. 8.


Pulmonary physiotherapy with assisted ventilation. Arterial blood gas tension changes following pulmonary physiotherapy with IPPB.


Effects of physiotherapy during intermittent positive pressure ventilation. Changes in arterial blood gas tensions.


Henry Percy Dean. An early British pioneer of spinal analgesia.


Gas removal systems for commonly used circuits.


Repair of the laryngopharynx and cervical oesophagus after irradiation.


Incorporation of fucose into HeLa cell plasma membranes during the cell cycle.


Monolayer interactions of individual lecithins with natural sterols.


A comparison of portal and systemic venous drainage in porcine renal allografts.


Cancer research: preparing for a long haul.


Lymphomatoid papulosis.

Lymphomatoid papulosis.


Effect of epidermal rotation on orientation of scales in the chick.


Edgar Zwilling 1913-1971.

Edgar Zwilling 1913-1971.


Preparation of immunochemically homogeneous hog pepsinogen and pepsin.


Impact of insulin on metabolic pathways. Recollections of 1921.


Opening address.

Opening address.


Endocrine-metabolic anomalies in rodents with hyperglycemic syndromes of hereditary and-or environmental origin.


Inductive effects of glucose on the insulin secretory and synthetic apparatus of the pancreatic  -cell.


Role of calcium in insulin secretion.

Role of calcium in insulin secretion.


Fat cell size and number in adipose tissue in relation to metabolism.


A simplified method for isolating bovine lymphocytes.


Insulin-glucagon ratio.

Insulin-glucagon ratio.


Organ culture of fetal rat pancreas: quantitative analysis by linear scanning of islet and other tissue components.


B-pancreatic function in obese and diabetic children.


Chairman's remarks.

Chairman's remarks.


The concept of diabetes in historical perspective.


Discovery of insulin told as a human story.


From the preinsulin age to the Banting and Best era. Reminiscences of a witness and participant.


The role of Paulesco in the discovery of insulin.


Parameters of the generation time distribution of Escherichia coli B-r.


Expression of the Escherichia coli K, B and phage P1 DNA host specificities in Salmonella typhimurium.


Obituary. Paul Fildes, 1882-1971.

Obituary. Paul Fildes, 1882-1971.


Transductional analysis of cysteine mutants in Proteus mirabilis.


Stereotaxic radiofrequency coagulation: a treatment for trigeminal neuralgia.


John Arthur Siegling, M. D. Orthopaedist.


Factors affecting mycelial to yeast phase conversion and growth of the yeast phase of Histoplasma capsulatum.


A new technique for isolating pathogenic fungi from mixed flora inocula.


On mycological fat production from Iraqi date extract: the dibis.


Specific heat measurements of poly-(L-alanine) at low temperatures (1.8-20 K) and aspects of one dimensionality.


How lac repressor binds to DNA.

How lac repressor binds to DNA.


Is "orbit steering" a new concept?

Is "orbit steering" a new concept?


Cyanate inhibition of erythrocyte glucose-6-phosphate dehydrogenase.


Possible role of 18-hydroxy-deoxycorticosterone in hypertension.


Chromosomal localization of human haemoglobin structural genes.


Light-evoked impulses from extra-ocular photoreceptors in the squid Todarodes.


Testosterone, search behaviour and persistence.


Control of sebum secretion by the posterior pituitary.


Stereopsis generated with Julesz patterns in spite of rivalry imposed by colour filters.


Evidence for stabilizing and apostatic selection by wild blackbirds.


Sexual selections by variations in fitness at breeding time.


[Hypothalamic luteotropic hormone releasing factor (LH-RH)].


Successful use of electric shock in a lifeless child as reported in 1774.


A physiologic rationale for the management of neurologic rectal incontinence in children.


Presentation of the C. Anderson Aldrich Award to Erik Erikson. I. From the introductory remarks by Benjamin M. Spock.


Presentation of the C. Anderson Aldrich Award to Erik Erikson. II. Remarks on receiving the C. Anderson Aldrich Award.


The importance of fathers in the rearing of children--two eighteenth century views.


Assay of the stimulatory effects of myelopoietic factor isolated from rat serum on granulopoiesis.


Neonatal tetanus in Iceland.

Neonatal tetanus in Iceland.


Relative importance of some factors affecting the electrophoretic migration of proteins in sodium dodecyl sulfate-polyacrylamide gels.


Preparation and analysis of L-( 35 S)methionine labeled transfer ribonucleic acids from rabbit liver.


A new method for continuous recording of the transketolase reaction.


Cell-free protein synthesis with sodium dodecyl sulfate and ADP.


Aluminum planchet counting: a simple method for improved sample spreading.


A rapid technique for the analytical and preparative isolation of transfer RNA from reaction mixtures.


The identification of trans-2-tetradecenoic acid in hydrolysates of lipid A from Escherichia coli.


Changes in positional distribution of fatty acids in the phospholipids of Escherichia coli after shift-down in temperature.


Structural specificity of bile acid for inhibition of sterol synthesis in cell-free extracts of yeast.


Chronic pulmonary heart disease.

Chronic pulmonary heart disease.


A quantitative assessment of tissue changes accompanying homograft reaction: changes in tissue dry weight, DNA and moisture content in rabbit skin homografts.


The language of schizophrenia: a review and interpretation.


Persistence of extra-pyramidal disorders and psychiatric relapse after withdrawal of long-term phenothiazine therapy.


Trial of a sustained release form of amitriptyline in the treatment of depressive illness.


Effect of shape of medication in treatment of anxiety states.


Early Arabian urologists. A historical review.


Post-prostatectomy management--a new catheter system.


The diagnosis and management of bacterial prostatitis.


Hepatitis and epidemic hepatitis associated antigen (E.H.A.A.) in a haemodialysis unit with observations on haemoglobin levels.


Increased susceptibility of the kidney to ascending Escherichia coli infection following unilateral nephrectomy.


Oral administration of a new carbenicillin in the treatment of urinary tract infection.


Kidney preservation: cryo-precipitated plasma perfusion and the progressive osmotic effect.


Repair-deficient bacterial strains suitable for mutagenicity screening: tests with the fungicide captain.


Prognostic accuracy of cervical cone biopsy.


The changing pattern of hospital-acquired infections: increase of infections by Gram-negative bacteria.


The bilirubin story.

The bilirubin story.


The surgical management of laryngotracheal injury.


A human immunoglobulin G with deletions in both heavy and light polypeptide chains.


Studies on milk intolerance. A review of literature for Latin America.


Fetal hemoglobin.

Fetal hemoglobin.


Iatrogenic problems in end-stage renal failure.


Release of protein from mouse motor nerve terminals.


Tension transients after quick release in rat and frog skeletal muscles.


Role of microexudate carpet in cell division.


Inhibition of mitosis in suspension culture of chick embryo cells.


Vespa larvae send out rhythmic hunger signals.


Artificial insemination with imprinted birds of prey.


Relationship between plasma cortisol and human sexual activity.


The impact of Medicaid on private care for the urban poor.


Seasonal variation in twin births.

Seasonal variation in twin births.


Possible mechanism for the genetic component of language.


Possible role of repeated nucleotide sequences in DNA in the evolution of life spans of differentiated cells.


Human growth hormone.

Human growth hormone.


Biosynthesis of mescaline and N-acetylmescaline by mammalian liver.


Difference in chromosome lengths between male and female sheep.


Termite queen substance: 9-oxodec-trans-2-enoic acid.


Delayed effects of juvenile hormone on insect metamorphosis are mediated by the corpus allatum.


Some effects of stress in the adult on the larval development of Mytilus edulis.


Plutonium and polonium inside giant brown algae.


Medicine at St. Andrews 1413-1972.

Medicine at St. Andrews 1413-1972.


Psychosomatic medicine. VII. Psychosomatic aspects of peptic ulcer disease.


Thioridazine as an antidepressant.

Thioridazine as an antidepressant.


Neural attenuation of responses to emitted sounds in echolocating rats. Bats of the family Vespertilionidae enmit strong ultrasonic pulses for echolocation. If such sounds directly stimulate their ears, the detection of echoes from short distances would be impaired. The responses of lateral lemniscal neurons to emitted sounds were found to be much smaller than those to playback sounds, even when the response of the auditory nerve was the same to both types of sounds. Thus, responses to self-vocalized sounds were attenuated between the cochlear nerve and the inferior colliculus. The mean attenuation was 25 decibels. This neural attenuating mechanism is probably a part of the mechanisms for effective echo detection.


Hyperplasia and tumors of the adrenal cortex.


Ribosome size distribution in extracts of potassium-depleted Escherichia coli.


Trimethoprim-induced accumulation of guanosine tetraphosphate (ppGpp) in Escherichia coli.


Genetic experiments with animal learning: a critical review.


Interaction of guanosine 5'-diphosphate, 2'-(or 3'-) diphosphate(ppGpp) with elongation factors from E. coli.


Protein synthesis in rabbit reticulocytes: characteristics of a Met-tRNA Met  f  binding factor.


Polarity and transcription in the galactose operon of E. coli.


L-asparaginase effects on intact murine leukemia cells and on isolated cell plasma membranes.


A possible role in the regulation of primary animation for a complex of glutamine:  -ketoglutarate amidotransferase and glutamate dehydrogenase in Escherichia coli.


The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL-KsJ and C57BL-6J strains.


Phosphoglucomutase gene in Aedes aegypti: a fourth allele and preliminary linkage data.


Maize endopeptidase: genetic control, chemical characterization, and relationship to an endogenous trypsin inhibitor.


Partition behavior of native proteins in aqueous dextran-poly(ethylene glycol)-phase systems.


Studies on the catalytic mechanism of pepsin using a new synthetic substrate.


Stabilization and breakdown of Escherichia coli messenger ribonucleic acid in the presence of chloramphenicol.


A model for nucleotide regulation of aspartate transcarbamylase.


The practice of medicine in 1921.

The practice of medicine in 1921.


Emphysema: historical persective.

Emphysema: historical persective.


Charles Darwin and Mrs. Whitby.

Charles Darwin and Mrs. Whitby.


A medical and social perception of the Vietnam veteran.


Hospitals depicted in old maps and panoramas. IV. Seventeenth century Geneva.


Acute spinal cord injury: a review of recent studies of treatment and pathophysiology.


A new calculation method for left-to-right shunts established by radiocardiography. Comparison with dye dilution techniques.


Long-term evaluation of lidoflazine in angina pectoris based on exercise tolerance.


Electron microscope methods applied to membranes.


Permeability and topography of membranes.


Studies on the molecular mechanism of the response of an excitable membrane to cholinergic agents.


Skin testing in the assessment of antiinflammatory drugs in man.


The effect of colestipol or cholestyramine on serum cholesterol and triglycerides in a long-term controlled study.


Placebo-controlled evaluation of phenaglycodol in anxious, depressed outpatients.


Clorazepate dipotassium in anxiety: a clinical trial with diazepam and placebo controls.


Some approaches and problems in the study of the use of services--an overview.


Isolation of the trypomastigote form of Trypanosoma cruzi from a mixture of the trypomastigote and epimastigote forms of the parasite by use of a DEAE-cellulose column.


Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J.


Physical state in which naphthalene and bibenzyl are utilized by bacteria. The generation times of a strain of Pseudomonas grown on a mineral salts medium in the presence of various amounts of naphthalene did not vary with the amount of solid present, and these generation times were the same as the generation time on mineral salts medium containing only dissolved naphthalene. The generation time of a soil isolate grown on mineral salts medium in the presence of 0.5 g of solid bibenzyl per liter was the same as the generation time on a mineral salts medium saturated with bibenzyl. The evidence indicates that naphthalene and bibenzyl are utilized in the dissolved state.


Hazard inherent in microbial tracers: reduction of risk by the use of Bacillus stearothermophilus spores in aerobiology. The use of a "biological tracer" forms an essential part of many aerobiological experiments. Where release of such tracers is likely to result in deliberate or inadvertent human exposure, safety becomes a primary consideration in the selection of the tracer organism. Of the three most commonly used organisms, namely Bacillus subtilis, Escherichia coli, and Serratia marcescens, only the first comes near to satisfying the need for nonpathogenicity and even it has been incriminated as a cause of human infection, sometimes with a fatal outcome. The relevant characteristics of B. stearothermophilus were, therefore, investigated. Because it can grow only at elevated temperatures (minimum 41 C; optimum 56 C), it should not pose a threat to human health and this view is supported by experimental evidence to be presented. It is extremely easy to grow and maintain in the laboratory, and spore suspensions are easily prepared and stored. It withstands the stresses of aerosolization and sampling and its stability in the aerosol state compares favorably with that of B. subtilis var. niger.


Microbial utilization of crude oil.

Microbial utilization of crude oil. The utilization of two crude oil samples of different quality at 4 and 30 C has been studied by using pure and mixed bacterial cultures obtained by enrichment procedures. Growth, emulsification, and utilization occurred readily at both temperatures. The crude oil residue is increased in specific gravity and readily sediments out of solution. A comparison of the chemical analysis of the oils by liquid and gas-liquid chromatographic procedures before and after growth showed that the n-saturate fraction had been preferentially used. Some utilization of the aromatic fraction also occurred. Enrichments obtained with a high-quality crude oil were not as effective in utilizing a lower quality crude oil as sole carbon source as a population enriched on the low-quality crude oil.


Bacteremia after genitourinary tract manipulation: bacteriological aspects and evaluation of various blood culture systems. A total of 300 patients undergoing various types of urological procedures was studied for incidence of bacteremia. An osmotically stabilized anaerobic broth with sodium polyanethol sulfonate (Liquoid) yielded more positive blood cultures than any other culture system and was also the best system by far for recovery of anaerobes. The membrane filter showed faster growth and, therefore, facilitated faster identification of the infecting organism. There was a 31% incidence of bacteremia in the patients having transurethral resection of the prostate, 17% in the cystoscopy group, 24% in the urethral dilation group, and 8% in the urethral catheterization group. The organisms found most frequently isolated in blood cultures were enterococci and Klebsiella pneumoniae. Notable were a relatively large number of anaerobes and two protoplasts. The major source of the bacteremia was previous urinary tract infection, but evidence is presented which indicates that the prostate gland and the normal urethral flora are other significant sources.


Selective medium for hydrogen sulfide production by salmonellae. Triple Sugar Iron Agar does not reveal hydrogen sulfide production by all Salmonella organisms nor does it permit clear-cut separation of those nonsalmonellae which produce H(2)S. Numerous media with varied combinations of nutrients, inhibitors, selective agents, pH levels, and metal salts were tested for H(2)S production of cultures of Salmonella, Citrobacter, Edwardsiella, Arizona, Proteus, Providencia, Klebsiella, and Enterobacter. An agar medium has been devised which promotes growth and H(2)S production (generally within 6 hr) by Salmonella, Arizona, and Edwardsiella but which inhibits hydrogen sulfide production or growth of all other gram-negative organisms tested (including Citrobacter) or inhibits both. The use of this medium should facilitate the selection and identification of Salmonella.


Effect of relative humidity on the inactivation of airborne Serratia marcescens by ultraviolet radiation. Apparatus was designed and constructed in which a bacterial aerosol of known age, particle size, and relative humidity (RH) could be exposed to ultraviolet (UV) radiation of measured intensity for a given period of time and then be sampled quantitatively. Aerosols of Serratia marcescens were exposed to UV dosages between 96.0 and 0.75 (muw-sec)/cm(2) at humidities ranging from 25 to 90%. A sharp decline in the fraction of organisms killed was found at RH values above 60 to 70%. Above 80% RH, there was evidence for reactivation induced by UV. The plot of "log fraction organisms remaining" versus UV dose was curvilinear, suggesting noncompliance with the monomolecular law of reaction velocity, but the Bunsen-Roscoe law of reciprocity between time and intensity of UV exposure was demonstrated to hold. These results could be accounted for by postulating the presence in the aerosol of two populations of organisms with different sensitivities to UV, each individually obeying the monomolecular law of reaction velocity. The data amplify existing information on the relationship between UV disinfection of airborne organisms and RH. In the middle range of humidities, the sensitivity of the organisms to UV was greater than would be expected from published reports.


Recognition of group D streptococcal species of human origin by biochemical and physiological tests. The speciation of 262 strains of group D streptococci isolated from human sources is described. One hundred forty-two isolates from blood cultures were included; 96 of these were submitted as isolates from clinical cases of subacute bacterial endocarditis. The results show that 98 Streptococcus faecalis, 29 S. faecalis var. zymogenes, 44 S. faecalis var. liquefaciens, 27 S. faecium, 13 S. durans, 44 S. bovis, and 7 unspeciated S. bovis-like group D isolates were identified. No S. faecium var. casseliflavus, S. equinus, or S. avium (group Q streptococci) were identified among the human isolates. The speciation procedures and techniques are detailed. The procedures and limitations of the tests used are discussed. Ninety-eight percent of the 262 strains were speciated by a spectrum of tests that allowed us to recognize atypical as well as typical strains within species.


Bacterial degradation of benzyl isothiocyanate. Bacteria that degrade benzyl isothiocyanate to benzylamine and hydrogen sulfide were isolated from papaya pulp homogenate by enrichment culture techniques. These organisms were identified as members of Enterobacter cloacae.


Susceptibility of gnotoibiotic swine to Escherichia coli isolated from nonenteric human infections. Newborn, germfree piglets were susceptible to Escherichia coli associated with human, nonenteric infections and should provide a useful model in the study of generalized E. coli infections.


New technique for biotyping.

New technique for biotyping. An efficient technique for biotyping, using disposable trays instead of glass tubes and agar instead of liquid media, is described.


The development of interpersonal relationships among long-stay patients in two hospital workshops.


Frames of reference in psychoanalytic psychology. II. The historical context and phases in the development of psychoanalysis.


Rehabilitation problems in spina bifida.


A review of medication errors and compliance in ambulant patients.


Electron microscopical identification of the immunofluorescent gastrin cells in the cat pyloric mucosa.


Effect of formalin fixation on the dry mass of isolated rat liver nuclei.


Adventures with antibacterial drugs.

Adventures with antibacterial drugs.


Holy Cross Hospital under seige: how it managed the Gov. Wallace Crisis.


Analgesic and other effects of nalmexone in man.


Effects of propranolol on marihuana-induced cognitive dysfunctioning.


An innovative surveillance and infection control program.


Effect of diketocoriolin B on antibody formation.


Methylphenidate in mildly depressed outpatients.


Treatment of parkinsonism by amantadine and levodopa.


Denaturation of myosin and its subfragments. II. Effect of thermal treatment on light meromyosins.


Sedimentation properties of yeast nuclear and mitochondrial DNA.


Heterogeneity of patch size in repair replicated DNA in Escherichia coli.


Specificity of protein synthesis by bacterial ribosomes and initiation factors: absence of change after phage T4 infection.


Drug therapy in minimal brain dysfunction: a commentary.


The estimation of perinatal pulmonary maturity: a commentary.


Adrenocorticosteroid treatment of hydrocarbon pneumonia in children--a cooperative study.


Continuous negative pressure in the management of severe respiratory distress syndrome.


Susceptibility of enteropathogenic E. coli to various antibiotics.


Hopi initiation rites--a case study of the validity of the Freudian theory of culture.


Effect of dextran sulphate on immunosuppresive activity of anti-lymphocyte serum.


Distribution of transferable drug-resistance factors in fecal Escherichia coli from healthy pigs.


Transfer of drug-resistance (R factor) among strains of Escherichia coli in gnotobiotic pigs.


Anaphylaxis in pigs and its relation to edema disease.


Hyperkalemia in anesthesia.

Hyperkalemia in anesthesia.


The puppet treatment in pediatrics.

The puppet treatment in pediatrics.


Intrauterine contraception.

Intrauterine contraception.


Immediate postabortal intrauterine contraceptive device insertion: a double-blind study.


Effects of sound on the female reproductive system.


Classic pages in obstetrics and gynecology.


Flunidazole--a new drug for systemic treatment of urogenital trichomoniasis.


Renal transplantation in a patient with Wegener's granulomatosis.


Simultaneous allografts of both kidneys in pigs with different portal and caval venous drainage.


Use of an air-fluidized bed in the care of patients with extensive burns.


Glycolate oxidoreductase in Escherichia coli.


tRNA structure and binding sites for cations.


A note on the history of medicine.

A note on the history of medicine.


Clausewitz: on psychotherapy. The lost manuscript of Wolfgang von Clausewitz.


Rational Egyptian surgery: a cranial injury discussed in the Edwin Smith Papyrus.


The contributions of Casper Neumann and Edmund Halley to demography.


The first decade. II. the sotry of the birth of Canadian Medicare in Saskatchewan and its development during the following ten years.


Further codon assignments in an extremely halophilic bacterium using a cell-free protein-synthesizing system and a ribosomal binding assay.


Psychiatric manifestations of levodopa.

Psychiatric manifestations of levodopa.


Psychotic reactions during organ transplantation.


The emotional response to the kidney transplant: the process of internalization.


The behavioural responses of renal transplant patients as seen through their fantasy life.


Psychological and psychopathological reactions in relation to chronic hemodialysis.


J. Grant Irving, M.D., F.R.C.S. 1907-1972.


Enamel etch resin restoration.

Enamel etch resin restoration.


Mechanism of copper-induced ovulation by the incubation experiment of the anterior pituitary gland.


Effects of synthetic luteinizing hormone-releasing hormone on plasma levels of luteinizing hormone and follicle-stimulating hormone in man.


The effect of horse-anti-dog-lymphocyte globulin (HALG) on the survival of cardiac allografts in horse immunoglobulin G(HIgG)-tolerant and in HIgG-sensitized dogs.


Prolonged skin allograft survival in vitamin C-deficient guinea-pigs. Preliminary communication.


Portal circulation in humans studied by a dye-dilution technique. A preliminary report.


Thymic involution and ageing: a hypothesis.


Quantitative study on the islets of langerhans of the beagle as a function of age.


The evolution of developmental psychology. A comparison of handbooks.


Idiopathic septic arthritis in dairy cattle.


Humoral and cellular antibody response in rabbits after intragingival injections of bovine serum albumin and Escherichia coli endotoxin.


A medical diploma of 1820.

A medical diploma of 1820.


Comparative studies with benisone (betamethasone 17-benzoate) in steroid-responsive dermatoses.


Personal constructs and friendship formation.


Acute interstitial nephritis. A distinct clinico-pathological entity?


Antigenic properties of enterotoxins and water extracts obtained from Escherichia coli pathogenic for pigs.


The influence of the contents of different K antigens and of physical factors on the toxicity of enterotoxins and water extracts of Escherichia coli.


The haemolytic action of faecal extracts from scouring calves.


Brain and body temperatures in a panting lizard. Panting in Sauromalus obesus is effective enough to keep deep body temperature (T(C)) and brain temperature (T(B)) below an ambient temperature of 45 degrees C for extended periods of time and has a greater cooling effect on the brain than on the remainder of the body. Six animals maintained T(C) and T(B) 0.9 degrees C (+/- 0.08 standard error) and 2.7 degrees C (+/- 0.2 standard error) respectively lower than the ambient temperature of 45 degrees C. It is possible that intracranial vascular shunts play a role in cranial cooling during panting.


Search for a common language.

Search for a common language.


Trypanosoma lewisi: duration of immune state in rats.


Measurements of human epidermal cells.

Measurements of human epidermal cells.


Temporal retrogasserian resection of trigeminal root versus controlled elective percutaneous electrocoagulation of the ganglion of gasser in the treatment of trigeminal neuralgia. Report on a series of 531 cases.


Regulation of pyruvate kinases by succinyl coenzyme A.


Luteinizing hormone-releasing hormone (LH-RH) activity of some synthetic polypeptides. I. Fragments shorter than decapeptide.


Ultraviolet inactivation and miscoding of irradiated R17-RNA in vitro.


Two forms of biosynthetic acetohydroxy acid synthetase in Salmonella typhimurium.


Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase.


Chemical modifications of transfer rna species. Heavy atom derivatization of aminoacyl tRNA.


Senear-Usher syndrome and internal malignancy.


Electron microscopy: a functional approach.


Clinical experiences with the streptococcal anticancer preparation, OK-432 (NSC-B116209).


Effect of concomitant drug treatment on toxic and therapeutic activity of 5-fluorouracil (5-FU; NSC-19893).


Clinical trial with mycophenolic acid (NSC-129185), a new antitumor agent.


Karyological studies of Japanese ants (Hymenoptera, Formicidae). 3. Karyotypes of nine species in Ponerinae, Formicinae, and Myrmicinae.


The 'Every' type acrylic partial denture.


Combined use of gas chromatography, mass spectrometry, and computer in diagnosis and studies of metabolic disorders.


Spread of dental infections.

Spread of dental infections.


Dental attrition and primitive corn milling.


Aminoacylation of fragment combinations from yeast tRNA phe .


Medical diagnosis: comparison of human and computer logic.


Computer-assisted diagnosis of metabolic bone disease using biochemistry test results.


Interaction of RNA polymerase from Escherichia coli with DNA. Selection of initiation sites on T 7 DNA.


Proteus urinary infections in childhood.


Cellular response in skin windows in Hodgkin's disease and allied disorders.


Deletion of hapten-binding cells by a highly radioactive 125-I conjugate. Exposure of normal mouse spleen cells in vitro to highly (125)I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier to which the hapten was bound. DNP-binding cells were inactivated by radioactivity that was not part of the hapten, but was solely confined to the carrier moiety. The deletion of the anti-DNP response lasted 2-3 wk and could be specifically inhibited.


Maturation of the immkune response in vitro. Focal fluctuation and changes in affinity of anti-beta-D-galactosidase activating antibody. We have cultivated lymph node microfragments from beta-D-galactosidase (Escherichia coli) primed rabbits and have measured their secondary response directed towards the whole molecule (precipitating antibodies) and to a single determinant (activating antibodies) of the antigen. By decreasing the size of the fragments to 10(5) cells, we began to observe heterogeneity among identical cultures in terms of positivity of response, antibody specificity, and titers. The affinity of "early" activating antibodies was inversely proportional to the dose of challenge. While no maturation was seen in low and excessive challenge, in all cultures receiving intermediate doses the association constant was raised several orders of magnitude within periods of 20 days. The relevance of these data to the mechanism of affinity selection of antigen-sensitive cells is discussed.


Immune response to a hapten coupled to a nonimmunogenic carrier. Influence of lipopolysaccharide.


Class, subclass, and allelic exclusion of membrane-bound Ig of human B lymphocytes. Membrane-bound immunoglobulins of peripheral blood B lymphocytes and of lymphocytes from an IgG chronic lymphocytic leukemia showed restriction to one immunoglobulin class, one IgG subclass, and one Gm allotype. Certain antigens in the C-terminal part of IgG Fc were not exposed on the cell surface.


Nephrology.

Nephrology.


Normal granulocyte transfusion therapy: treatment of septicemia due to gram-negative bacteria.


Female homosexuality.

Female homosexuality.


Herbal medicines to avoid.

Herbal medicines to avoid.


Chesowanja Australopithecine.

Chesowanja Australopithecine.


Effectiveness of combining title words and index terms in machine retrieval searches.


Dr W. R. Thompson.

Dr W. R. Thompson.


Dr Vilmos Várterész.

Dr Vilmos Várterész.


Circadian variation of RNA in human leucocytes.


Stereochemical requirements of the mescaline receptor.


Keratoblast and keratocyte, not keratinocyte.


Effect of PABA on chloroquine resistance in Plasmodium berghei yoelii.


Evidence for the existence of latent myxoma virus in rabbits (Oryctolaqus cuniculus(L.)).


The early effects of alloantibody and complement on rat kidney allografts.


Leukocyte migration in vitro and its relationship to human renal allograft rejection and enhancement.


Biological properties of transplantation immune sera. 3. Relationship between transplantation (facilitation or inhibition) and serological (anaphylaxis or cytolysis) activities.


A new model for study of allograft rejection in the rat: use of skin with an intact vascular pedicle. I.


Comparison of male and female kidney transplant survival rates.


Time relationships in the development of immunity to urodele skin allografts transplanted across weak histocompatibility barriers.


X- and Y-linked transplantation antigens in rats.


Platelets levels during rat skin allograft rejection.


Histocompatibility antigens in the dog and their inheritance in three litters of pups.


The effect of neuropharmacological agents on metabolism in vitamin B6 in brain.


The role of prejunctional effects in myoneural transmission.


The purification of aminoacyl-tRNA synthetases by affinity chromatography.


The five possible causes of all nutrient deficiency: illustrated by deficiencies of vitamin B 12 and folic acid.


The juxtaglomerular apparatus in renal allograft rejection: histological and ultrastructural study.


Polynucleotides. XI. Synthesis and properties of poly(2-methylinosinic acid).


Inhibitory effects of acid polysaccharides from sea urchin embryos on RNA polymerase activity.


On the mode of reaction of formaldehyde with ribosomes.


San Mateo County Dental Society. 1971-72 Directory.


Cytogenetic aspects of induced and spontaneous abortions.


Fifty years of Milford Hospital.

Fifty years of Milford Hospital.


Present status and future trends in prenatal diagnosis of chromosomal disorders.


The surgical handling of oral tissues.

The surgical handling of oral tissues.


Prevention "gimmicks".

Prevention "gimmicks".


Report of the Indian Hemp Drugs Commission, 1893-94: a critical review.


Iron, blood, and nutrition.

Iron, blood, and nutrition.


The family of the addict: a review of the literature.


Chorismate mutase-prephenate dehydratase from Escherichia coli K-12. I. Purification, molecular weight, and amino acid composition.


Tryptophan synthetase   chain positions affected by mutations near the ends of the genetic map of trpA of Escherichia coli.


Dehydrogenase activity involved in the uptake of glucose 6-phosphate by a bacterial membrane system.


Properties of the phage f2 replicase. I. Optimal conditions for replicase activity and analysis of the polynucleotide product synthesized in vitro.


Kinetics and mechanism of pepsinogen activation.


Properties of the phage f2 replicase. II. Comparative studies on the ribonucleic acid-dependent and poly (C)-dependent activities of the replicase.


Nucleotide sequence analysis of deoxyribonucleic acid. VI. Determination of 3'-terminal dnucleotide sequences of several species of duplex deoxyribonucleic acid using Escherichia coli deoxyribonucleic acid polymerase I.


Nucleotide sequence analysis of deoxyribonucleic acid. VII. Characterization of Escherichia coli exonuclease 3 activity for possible use in terminal nucleotide sequence analysis of duplex deoxyribonucleic acid.


A simplified photographic technique for the reconstruction of tissue from plastic embedded specimens.


Studies on transfer ribonucleic acid-ribosome complexes. XIX. Effect of antibiotics on peptidyl puromycin synthesis on polyribosoms from Escherichia coli.


Spirit of inquiry.

Spirit of inquiry.


A dental problem--adhesion.

A dental problem--adhesion.


Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters.


Antitumor and mutagenic properties of a variety of heterocyclic nitrogen and sulfur mustards.


A clinical and histologic evaluation of a conditioning material.


Prevention and treatment of iron deficiency in children.


Background of clinical electrostimulation. VII. Modern era of artificial cardiac pacemakers.


Veterans administration dental health care program.


Lipid metabolism during cold-exposure and during cold-acclimation.


Composition of the alkali resistant cell wall material of dimorphic Blastomyces dermatitidis.


Inactivation of amphotericin B by reducing agents: influences on growth inhibition of Candida albicans and lysis of erythrocytes.


A cell-free amino acid incorporating system from yeast-phase cells of Histoplasma capsulatum.


The assay of delayed hypersensitivity to ribosomal proteins from Nocardia.


In vitro susceptibility of Cryptococcus neoformans to steroids.


Growth and form in Candida albicans.

Growth and form in Candida albicans.


Cardiac zygomycosis in an Australian parakeet.


Inhibition of catalase activity of Candida albicans by serum.


Lead in hair among exposed workers.

Lead in hair among exposed workers.


The metabolic function of oxygen and biochemical lesions of hypoxia.


Iron ligands in different forms of ferricytochrome c: the 620-nm band as a probe.


Cytochromes of Escherichia coli.

Cytochromes of Escherichia coli.


Apparent cytochrome gene dose effects in F-lac and F-gal heterogenotes of Escherichia coli.


The metabolism of D-arabinose: alternate kinases for the phosphorylation of D-ribulose in Escherichia coli and Aerobacter aerogenes.


Further studies on metabolism of phosphatidic acid of isolated E. coli membrane vesicles.


Permeability of a model lipid membrane to T 4 .


Some uses of polyester resin.

Some uses of polyester resin.


Hydrocortisone 17-butyrate, a new synthetic topical corticosteroid.


A comparative study of two fat-stored oestrogens in inhibiting lactation.


Bromhexine hydrochloride in chronic secretory otitis media--a clinical trial.


Changes in serum trypsin inhibitors induced by the administration of proteolytic enzyme tablets to surgical patients.


A comparison of trimethoprim-sulphamethoxazole compound and tetracycline in exacerbations of chronic bronchitis. A double-blind multi-centre trial on in-patients.


Response to progressive exercise: a three-index test.


Some stepping stones in the history of chest medicine.


Trial of a terbutaline aerosol in the treatment of asthma and a comparison of its effects with those of a salbutamol aerosol.


Hereditary crystalline stromal dystrophy of Schnyder. II. Histopathology and ultrastructure.


Treponemal infection in the Australian Northern Territory aborigines. For many years, a moderate to high prevalence of positive reactions to standard tests for syphilis (STS) has been found in sera from the aboriginal inhabitants of the Northern Territory of Australia. In the survey reported here, people living in 18 areas of the Northern Territory were sampled to determine if the positive STS results were due to treponemal infection and, if so, to what extent this was endemic syphilis, yaws, or venereal syphilis. The results of the Treponema pallidum immobilization test were taken to indicate the presence or absence of treponemal disease in the subject. Clinically, no cases of active treponemal infection were seen, though findings on old infections were difficult to interpret in the older age groups. The prevalence of treponemal infection varied from 3.4% to 58.0% in the areas tested. No serological evidence of treponemal infection in children under 15 years of age was found in 6 areas, while in 12 areas it varied from 2.2% to 32.6%. Sera from 60 people who had no clinical signs of treponemal infection gave high-titre CWR and VDRL test results. It was concluded that yaws, endemic syphilis, and probably venereal syphilis are to be found in the aboriginal population.


A cytoplasmic polyhedrosis virus in midgut cells of Anopheles stephensi and in the sporogonic stages of Plasmodium berghei yoelii. Although it has been known for some time that nuclear and cytoplasmic polyhedrosis viruses may infect the larval stages of mosquitos capable of transmitting mammalian malaria this paper reports for the first time the presence of a cytoplasmic polyhedrosis virus in adult Anopheles stephensi. The virus was shown to be present in sporogonic stages of Plasmodium berghei yoelii with which the mosquitos were infected. It is possible that other viruses may affect both vector and malaria parasites. Further studies are required of viral infections in mosquitos as a possible method of biological control.


Halothane and the liver: a review of the epidemiologic, immunologic and metabolic aspects of the relationship.


Immunopathology of nephritis in Africa.

Immunopathology of nephritis in Africa. Clinicians have long suspected a relationship between malaria and nephritis in Africa. The results of tests made several years ago suggested that the relationship might be an immunological one. This memorandum discusses clinical, epidemiological, morphological, and immunopathological aspects of malaria-associated nephropathy, will special emphasis on immunological investigations. Immunofluorescence studies on renal biopsies from patients with the nephrotic syndrome and Plasmodium malariae parasitaemia have shown the presence of immunoglobulin (Ig) deposits with certain complement components on glomerular basement membranes. IgG with anti-P. malariae specificity has been found in eluates of kidney tissue from such patients and P. malariae antigen was identified in the glomerular basement membrane by immunofluorescence studies. These observations support the view that the nephropathy associated with P. malariae infections is a form of immune complex nephritis initiated by circulating P. malariae antigens and anti-P. malariae antibodies. Additional support is obtained from electron microscope studies, which show that electron-dense material is associated with the glomerular basement membrane in certain diseases of the kidney in which immune complexes have been detected in glomeruli by immunofluorescence methods. The view that malarial nephritis is a form of immune complex disease should be useful in stimulating new approaches to the study of the pathogenesis of both the initiating and the perpetuating immunopathological lesion.


The effects of nitrogen mustard on the survival of murine hematopoietic stem cells.


Studies on the mechanism of action of UDP-D-glucose dehydrogenase from beef liver.


Augmentation by dihydroergotamine of lipolysis stimulated by shole and pepsin-digested human growth hormone.


Crossed fused renal ectopia with calcific cystic dysplasia mimicking a malignant renal neoplasm.


The complications of respirator therapy in the newborn.


Zing-Yang Kuo: radical scientific philosopher and innovative experimentalist (1898-1970).


The management of post-operative pharyngo-cutaneous pharyngeal fistulae.


The indirect fluorescent antibody test for the serodiagnosis of stongyloidiasis.


The three flaps dacryocystorhinostomy.

The three flaps dacryocystorhinostomy.


Electrophysiological correlates of melanocyte-stimulating hormone activity in the frog.


Experience with systemic candidiasis in the burned patient.


Blood levels of thrombocytes in burned patients: observations on their behavior in relation to the clinical condition of the patient.


Pathology of organ transplantation in man.


The pathologist and modern breast cancer management.


Endometrial hyperplasias, precursors of endometrial carcinoma.


The pathologist and the kidney transplant.


Changing pathology in the 1970s.

Changing pathology in the 1970s.


Histogenesis and biologic behavior of gastric carcinoma.


Rhabdomyosarcoma: an ultrastructural appraisal.


The effect of methylphenidate (ritalin) on sustained attention in hyperactive children.


Dose responses and relationships between anticholinergic activity and mood with tricyclic antidepressants.


Radionuclide imaging of the central nervous system in children.


Immunologic abnormalities: roentgen observations.


Excretory urography in the first year of life.


Vincristine-induced syndrome of inappropriate secretion of antidiuretic hormone.


A renal transplantation program: its development in a new medical center.


Experience with steroids, albumin, and diuretics in progressive pulmonary insufficiency.


Pneumothorax: a complication of modern life.


Reconstruction of the thumb by radial nerve innervated cross-finger flap.


Studies on Escherichia coli in pigs. 3. Serological investigations of "unclassified" Escherichia coli strains.


The epidemiological approach to psychiatric disorders.


Aortic dissections and dissecting aneurysms.


Simon Samuel (1867) on inflammation. II.


Purification and properties of the mannokinase from Escherichia coli.


Stimulation of chloroplast DNA-dependent RNA polymerase by exogenous DNA.


Yeast pyruvate kinase renaturation after dissociation by guanidine-HCl.


Rejection crises in human renal transplant recipients: control with high dose methylprednisolone therapy.


Acute pancreatitis and hyperamylasemia in renal homograft recipients.


The crossmatch profile and other extended crossmatch methods in clinical transplantation.


Coagulation and platelet changes in rejected renal allografts.


Pulmonary complications in transplant recipients.


An operation for tracheal-innominate artery fistula.


Surgical management of "vascular rings".


Canine hemophilia and hemopoietic grafting.


Aplastic anemia.

Aplastic anemia.


Multiplication of haemopoietic colony forming units (CFU) in mice after x-irradiation and bone marrow transplantation.


Salvaging a fixed bridge after crown or abutment failure.


Effect of lysosomes on cultured rabbit corneal endothelial cells.


Primary rejection of thyroid allografts in the anterior chamber of the rabbit eye.


Repairing badly damaged abutment teeth.

Repairing badly damaged abutment teeth.


Diabetogenous peripheral microangiopathy.


Collaborative study of a method for the determination of commercial sterility of low-acid canned foods.


Modern use of the biopsy in the diagnosis of neurological disease.


Effect of rubella vaccine on transplacental rubella virus infection in rabbits.


Chlamydomonas flagella. I. Isolation and electrophoretic analysis of microtubules, matrix, membranes, and mastigonemes. Methods were developed for the isolation of Chlamydomonas flagella and for their fractionation into membrane, mastigoneme, "matrix," and axoneme components. Each component was studied by electron microscopy and acrylamide gel electrophoresis. Purified membranes retained their tripartite ultrastructure and were shown to contain one high molecular weight protein band on electrophoresis in sodium dodecyl sulfate (SDS)-urea gels. Isolated mastigonemes (hairlike structures which extend laterally from the flagellar membrane in situ) were of uniform size and were constructed of ellipsoidal subunits joined end to end. Electrophoretic analysis of mastigonemes indicated that they contained a single glycoprotein of approximately 170,000 daltons The matrix fraction contained a number of proteins (particularly those of the amorphous material surrounding the microtubules), which became solubilized during membrane removal. Isolated axonemes retained the intact "9 + 2" microtubular structure and could be subfractionated by treatment with heat or detergent. Increasing concentrations of detergent solubilized axonemal microtubules in the following order: one of the two central tubules; the remaining central tubule and the outer wall of the B tubule; the remaining portions of the B tubule; the outer wall of the A tubule; the remainder of the A tubule with the exception of a ribbon of three protofilaments. These three protofilaments appeared to be the "partition" between the lumen of the A and B tubule. Electrophoretic analysis of isolated outer doublets of 9 + 2 flagella of wild-type cells and of "9 + 0" flagella of paralyzed mutants indicated that the outer doublets and central tubules were composed of two microtubule proteins (tubulins 1 and 2) Tubulins 1 and 2 were shown to have apparent molecular weights of 56,000 and 53,000 respectively


Spironolactone-induced hypercalciuria.

Spironolactone-induced hypercalciuria.


The treatment of common dermatoses with topically applied 0.05 per cent desonide cream. A paired-comparison clinical study.


What no one knows, though everyone should, about IPPB machines. IV. Monaghan.


It-scale for children and Draw-a-Person test: 30 feminine vs. 25 masculine boys.


Family Relations Test responses of retarded readers: reliability and comparative data.


Opium alkaloids. XII. Quantitative determination of morphine in opium by isotope dilution.


Effect of nonionic surfactant on bactericidal activity of cetylpyridinium chloride.


A case report. Impacted third molar fixed bridge abutment.


Synthesis and growth-promoting activity of dl-cis-hexahydro-4-(4-carboxybutyl)-2-cyclopentimidazolone: carbobiotin.


An editorial. R.H.K.

An editorial. R.H.K.


Rudolph H. Kampmeier, M.D.

Rudolph H. Kampmeier, M.D.


Fermentation industry--pharmaceuticals, corn, sugar.


Eutrophication.

Eutrophication.


Wastewater treatment. Physical and chemical methods.


An unusual type of ameloblastoma with a review of the literature.


Anaerobic processes.

Anaerobic processes.


Lagoons and oxidation ponds.

Lagoons and oxidation ponds.


Water reclamation and reuse.

Water reclamation and reuse.


Disinfection.

Disinfection.


Hemodynamic studies on hypertension. I. Hemodynamic characteristics in the resting supine position.


Plasmodium malariae imported from Vietnam.


A dye densitometer for measuring cardiac output.


The principle design and features of a new Hb-oximeter.


Drug interactions in clinical medicine.

Drug interactions in clinical medicine.


Treatment of ventricular arrhythmias in ambulatory patients.


Enhanced recovery of rII mutations in the absence of selection in a ligase-negative mutant of bacteriophage T 4 .


5-bromouracil sensitization of pol + and pol Ai bacteria to the lethal action of some physical and chemical agents.


The mutagenic activity of  -propiolactone in Saccharomyces cerevisiae.


What kind of informed consent?

What kind of informed consent?


Tranexamic acid therapy in hereditary angioneurotic edema.


Possibilities and problems of immunologic intervention in cancer.


Squamous cell carcinoma developing in an artificial vagina.


Relief of intractable pain in cervical carcinoma with percutaneous radiofrequency cordotomy.


Effect of cyproheptadine on anorexia and loss of weight in adults.


Extrinsic allergic alveolitis.

Extrinsic allergic alveolitis.


Pimozide in anxiety neurosis.

Pimozide in anxiety neurosis.


Deaths of composers.

Deaths of composers.


Knotting of an 8-French "headhunter" catheter and its successful removal.


Compartmental analysis of the 133Xe regional myocardial blood-flow curve.


Unrecognized trauma in infants, the battered child syndrome, and the syndrome of Ambroise Tardieu. Rigler Lecture.


Wendell G. Scott, M.D. 1905-1972.

Wendell G. Scott, M.D. 1905-1972.


Nathan M. Starkman, M.D. 1918-1972.

Nathan M. Starkman, M.D. 1918-1972.


The role of radionuclides in the evaluation of pancreatic blood flow, size, and exocrine function.


Pancreas scanning after ten years.

Pancreas scanning after ten years.


Protein-losing enteropathy and kinetic studies of plasma protein metabolism.


Disease of the silk worms; Pasteur in the Cevennes; his relations with Adrien Jeanjean, mayor of Saint-Hippolyte-Du-Fort.


Charles Edward Brown-Séquard--physician, endocrinologist, neurologist, physiologist.


Coumarin skin necrosis complicating thrombophlebitis and pulmonary emboli: case report.


New developments in lower-limb orthotics through bioengineering.


Cephalexin in the prevention of purulent exacerbations of chronic bronchitis.


Effect of Complan on underweight patients after gastric surgery.


Mebeverine in post-vagotomy diarrhoea. Report of a multicentre, double-blind trial.


Clinical trial of fluclorolone acetonide, a new topical steroid.


New decontamination procedure cuts costs--reduces staff time.


Personality and academic attainment.

Personality and academic attainment.


1972-1973 directory of constituent and component officers.


Arizona State Dental Association 1972 roster.


Temporary orthodontic bonding technic for the G.P.


Structure-function and structure-immunoreactivity relationships of the glucagon molecule and related synthetic peptides.


Comparison of the inhibitory effects of diphenylhydantoin and diazoxide upon insulin secretion from the isolated perfused pancreas.


Muscle capillary basement membrane changes related to aging and to diabetes mellitus.


Response of peripheral blood lymphocytes from patients with diabetes mellitus to phytohemagglutinin and Candida albicans antigen.


Inhibition of liver lactate dehydrogenase by serotonin: possible relationship to endotoxin effects.


1972 roster of the Greater St. Louis Dental Society.


The growth of tumour allografts as a measure of the immunosuppressive potency of antilymphocyte sera.


Bursal origin of bone marrow cells with competence for antibody formation.


The distribution of antibody and antibody-producing cells after immunization with xenogeneic cells.


Response of mice to rabbit Fab' 2  and Fab'. Thymus independence of IgM response and thymus dependence of IgG response.


Increased production of plaque-forming cells in mouse lymph nodes following regional injection of a second antigen.


A deconditioning therapy based upon concepts of Patanjali.


The Worcester State Hospital Research on schizophrenia (1927-1946).


Co-operative binding of histones to DNA.


Ribosomal RNA synthesis in isolated nuclei.


Interaction of siomycin with the acceptor site of Escherichia coli ribosomes.


Handling of files on mini-computers.

Handling of files on mini-computers.


1972 membership directory Greater Kansas City Dental Society.


Rousseau advises parents not to reason with children.


What a healthy two- or three-year-old child was fed in 1839.


Urinary tract infections in children. I. Females aged 2 through 14, first two infections.


Fables for the instruction of youth published in Boston in 1818. Excerpt II: Old hound and his master.


Tracheal reconstruction with an autogenous mucochondrial graft.


Management of epistaxis in Osler-Weber-Rendu disease: recurrence of telangiectases within a nasal skin graft.


Method for a rapid and good thumb reconstruction.


Free composite lip grafts.

Free composite lip grafts.


The double-V excision for better repair of lower lip defects.


The storage of split-skin grafts on their donor sites.


Further experiences with the retroauricular temporal flap.


Reconstruction of the lower eyelid by a different lid-splitting operation: case report.


Immediate composite graft to loss of nasal ala from dog bite: case report.


Repair of a cryptotic ear with a trefoil flap: case report.


New fixation device for cross-leg flaps.


Immunologic analysis by quantitative fluorescent antibody methods of effects of prolonged cultivation on Histomonas meleagridis (Smith).


The occurrence and significance of abnormal bile duct epithelium in chronic aggressive hepatitis. A comparative morphological biochemical, immunological, and prognostic study.


Renal transplantation in rabbits. VII. IgG deposits in allografts from recipients with lymphocytotoxic antibodies induced by multiple skin-grafts.


Carbenicillin indanyl sodium, an orally active derivative of carbenicillin. Carbenicillin indanyl sodium, an orally active derivative of carbenicillin, is active against a broad spectrum of bacterial species. Although the ester has in vitro antimicrobial activity per se when evaluated in Brain Heart Infusion broth, the in vivo antibacterial activity seen in mice and rats reflects primarily the efficient hydrolysis of the ester to carbenicillin. With an acute systemic infection in mice as a test system, orally administered carbenicillin indanyl sodium protected mice against lethal infections produced by Escherichia coli, Salmonella choleraesuis, Pasteurella multocida, Proteus vulgaris, Staphylococcus aureus, and Streptococcus pyogenes. The dose that protected 50% of the animals against each of these infections was comparable to that of parenteral carbenicillin. Against experimental urinary-tract disease in rats produced by E. coli, P. vulgaris, and Pseudomonas aeruginosa, it was again observed that carbenicillin indanyl sodium provided activity comparable to that of parenterally administered carbenicillin.


Polysome metabolism in Escherichia coli: effect of antibiotics on polysome stability. A number of antibiotics, most of which specifically inhibit protein synthesis by interacting with the 50S ribosome subunit, were used to study polysome metabolism in vivo. The antibiotics affected polysomes in two ways: (i) by allowing extensive breakdown of polysomes, or (ii) by stabilizing polysomes, even in the presence of the antibiotics of the first group. The results indicate that the effect of these antibiotics on polysome stability in vivo can, in many cases, be correlated to their in vitro mode of action.


Polysome metabolism in Escherichia coli: amicetin, an antibiotic that stabilizes polysomes. Amicetin, an aminohexosepyrimidine nucleoside antibiotic, inhibited protein synthesis in intact bacterial cells and in cell-free extracts derived from these cells. At concentrations of antibiotic which rapidly and completely inhibited protein synthesis, the polysomes in the cell were stabilized. Amicetin also inhibited the breakdown of polysomes induced by the streptogramin A antibiotics, rifampin, or puromycin, antibiotics that require peptide bond formation for expression of their action on polysomes. Thus, amicetin is another addition to the list of drugs which may be useful in studying polysome and messenger ribonucleic acid metabolism in vivo. An in vitro system is described which may be generally useful in studying polysome metabolism when antibiotic-sensitive strains are not available.


In vitro studies of the combined effect of ampicillin and sulfonamides on Nocardia asteroides and results of therapy in four patients. The minimal inhibiting concentrations (MIC) of ampicillin, trisulfapyrimidines, and various combinations of these drugs were determined for four clinical isolates of Nocardia asteroides on Mueller-Hinton agar. The combination of ampicillin and sulfonamides was found to be synergistic for three of the four isolates when an inoculum of 10(3) to 10(4) organisms per ml was used. (Synergism was defined as occurring when the MIC of each of the drugs in combination was one-quarter or less of the MIC of each drug alone.) All four isolates were inhibited by concentrations of the drugs in combination that were clinically achievable. Combined therapy with ampicillin and sulfonamides was used in four immunologically suppressed renal transplant patients who had pulmonary infection with N. asteroides. Clinical improvement was noted within 2 weeks in all patients, and the pulmonary infiltrates cleared by 6 months in three patients. One patient died from an unrelated illness 10 days after starting therapy. The disease was arrested in two patients who were maintained on full immunosuppressive therapy.


Conditions influencing antimycin production by a Streptomyces species grown in chemically defined medium. OPTIMAL CONDITIONS FOR PRODUCING CONSISTENT YIELDS OF ANTIMYCIN A IN CHEMICALLY DEFINED MEDIUM INCLUDED: (i) initial pH of 6.8 to 7.1; (ii) no iron supplementation; (iii) 2 g of dl-tryptophan per liter; and antibiotic extraction after 7 to 9 days of growth.


Professional and economic requirements for a system of health care delivery.


Spontaneous perforation of congenital sclerocornea.


A systematic study of the isolation of murine plasma cell ribosomal subunits, their sedimentation properties and activity in polyphenylalanine synthesis.


Glutaraldehyde fixation of ribosomes. Its use in the analysis of ribosome dissociation.


Glutaraldehyde reactivity of the proteins of Escherichia coli ribosomes.


Kinetic spectroscopic studies of substrate and subunit interactions of tryptophan synthetase.


The use of analogue telephone data links for the transmission of physiological signals.


Oxalosis in renal transplants following methoxyflurane anaesthesia.


Cyclopropane anaesthesia for renal transplantation. Report of 100 cases.


Behaviour of bovine spermatozoa in media of varying osmolality and tonicity.


Computer measurement of cardiac output by dye dilution: comparison of computer, Fick, and Dow techniques.


Evolution of marrow regeneration as revealed by transplantation studies.


The use of nerve blocks for studying cardiopulmonary physiology in man.


Effect of truncal vagotomy on acid and pepsin: response to a cholinergic drug in man. The gastric output of acid and pepsin in response to two doses of the cholinergic drug carbachol was measured before and two months after complete truncal vagotomy and pyloroplasty in eight patients with duodenal ulcer. After vagotomy the basal output of acid and pepsin was reduced and there was no stimulation of secretion by a subthreshold dose of carbachol (0.5 units/kg) nor was there an increase in the response to a submaximal dose of carbachol (2.0 units/kg).Cannon's criteria for denervation supersensitivity of an organ were not obeyed with regard to acid or pepsin secretion.


Historical notes: centennial year, American Public Health Association 1872-1972. Laboratory Section founded in 1899.


Hormonal control of pancreatic endocrine and exocrine secretion.


Evaluation of plating media and temperature parameters in the isolation of selected enteric pathogens.


Intro-extra-version as an organizing principle in fantasy production.


Intro-extra-version as an organizing principle in fantasy production. Comment.


Malaria among heroin users.

Malaria among heroin users.


Use of the bentonite flocculation test for the diagnosis of schistosomiasis.


Chemistry and the two organic kingdoms of nature in the nineteenth century.


Ivory anatomical manikins.

Ivory anatomical manikins.


The physician and witchcraft in restoration England.


History of Crichton Royal.

History of Crichton Royal.


The evolution of geriatric psychiatry.

The evolution of geriatric psychiatry.


Osler transmitted--a study in humanism.

Osler transmitted--a study in humanism.


The dilated pupil and head trauma 1517-1867.


Imparired DNA synthesis and envelope defect in a mutant of Salmonella typhimurium.


Defective cell division in thermosensitive mutants of Salmonella typhimurium.


[Coexistence of polA and recB mutations of Escherichia coli in the presence of sbc, a mutation which indirectly suppresses recB].


Use of disomic strains to study the arrangement of ribosomal cistrons in saccharomyces of ribosomal cistrons in Saccharomyces cerevisiae.


Chemical fractionation of immunosuppressive gamma-immunoglobulins from anti mouse-thymocyte serum (ATS).


Functional heterogeneity of the 30S ribosomal subunit of Escherichia coli. II. Effect of S21 on initiation.


Isolation and characterization of lactose non-utilizing mutants in Aspergillus nidulans.


Reduction mammaplasty based on vertical vascular bipedicle and "tennis ball" assembly. A different approach.


Studies on the interaction between ribosomes and  14 CH 3 -F 3  initation factor.


Tensile properties and morphology of healing wounds in young and old rats.


Healing of split skin autografts after storage in deuterated medium. An experimental study.


The repair of large incisional hernias with pedicle skin flaps. A new technique.


The effect of halothane on tissue necrosis in pedicle skin flaps in pigs.


Maturation of collagen in healing wounds in young and old rats.


The blood flow in experimental skin flaps in rats studied by means of the  133 xenon clearance method.


The anatomy of the blood brain barrier: a review.


Plastic surgery treatment of chronic venous ulcers of the leg.


Mammary tumors in control rats: literature tabulation.


Metabolism and blood pressure effects of disodium nitrilotriacetate (Na 2 NTA) in dogs.


Insensitivity to caffeine of phage-controlled repair-processes.


Immunodiabetes in the guinea pig. I. Light microscopy.


Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. I. Studies involving their incorporation of tritiated thymidine and their content of lysosomal enzymes and bacilli. Dermal and pulmonary tuberculous lesions were produced in rabbits with BCG, biopsied, incubated in vitro with tritiated thymidine ((3)HT) under hyperbaric oxygen, quickly frozen, sectioned in a cryostat, stained for the lysosomal enzyme beta-galactosidase, autoradiographed, stained for acid-fast bacilli and counterstained with hematoxylin. As macrophages developed into epithelioid cells, they could still divide-ie, incorporate (3)HT. However, once they became fully mature epithelioid cells that were 4-plus in beta-galactosidase, they could not do so. Tuberclebacilli did not stimulate macrophage division. On the contrary, macrophages containing bacilli did not divide, except when the lesions began. During the development of tuberculous lesions, macrophages (including those rich in enzymes and those containing bacilli) died, forming caseous centers. Therefore, local cell division did not seem to be the main mechanism by which macrophages reduced their bacillary load. Such division seemed mainly to occur in young macrophages that had recently immigrated into the lesions from the bloodstream and had not yet ingested bacilli.


Endotoxin-induced hepatic damage in BCG-infected mice. Systemic infection of mice with Mycobacterium BCG leads to focal liver damage by producing many granulomas. By undefined mechanisms, this infection markedly enhances the animal's susceptibility to the lethal effect of endotoxin. Small doses of endotoxin given to BCG-infected mice were found to cause acute hepatic damage, as demonstrated by elevated activities of liver enzymes in serum and by morphologic alterations documented by light and electron microscopy and by histochemical technics. The morphologic alterations caused by endotoxin included glycogen depletion, mitochondrial swelling, disruption of the continuity of sinusoidal endothelium and focal injury characterized by marked vacuolization of hepatocytes and distension and fragmentation of rough endoplasmic reticulum. Histochemical studies revealed the apparent release of acid phosphatase from granules in the central portions of granulomas, and the release of beta-glucuronidase from the cytoplasm of hepatocytes.


Renovascular hypertension in children. Report of seven cases treated surgically including two cases of renal autotransplantation.