Mortality from heat illness and heat-aggravated illness in the United States.


Photomicrography of bacterial cells: a rapid method for surveying bacterial morphology.


Histochemical analysis of metachromasia of galactogen: a confirmatory technique for histochemical detection of galactogen.


Electron probe analysis of the calcium distribution in cells of the embryonic chick chorioallantoic membrane. I. A critical evaluation of techniques.


Drug distribution and renal failure.

Drug distribution and renal failure.


Studies on the physiological availability and metabolism of sulfonamides. 3. Triple sulfa.


Fluorescence histochemistry of biogenic monoamines. A study of the capacity of various carbonyl compounds to form fluorophores with biogenic monoamines in gas phase reactions.


The fate of exogenous peroxidase in the thymus of newborn and young adult mice.


Esterase markers in mouse radiation chimeras.


The effect of light microscopic fixatives on the retention of glycogen in protein matrices and the particulate state of native glycogen.


Water-borne typhoid fever caused by an unusual Vi-phage type in Edinburgh. Investigation of a small series of cases of typhoid fever infected in a river between 1963 and 1970 revealed that all were caused by a single source, a carrier of a rare phage type of Salmonella typhi. The contamination of the river resulted from an incorrect sewage connexion with a surface water drain outfall into the river.


Redox potential measurements for determining the disinfecting power of chlorinated water. The kill of Escherichia coli within 3 min. was studied in chlorine-demand-free water using sodium hypochlorite, monochloramine, dichloramine, halazone, chloramine T, cyanuric acid + sodium hypochlorite and cyanuric acid + monochloramine. The redox potential and the available chlorine were measured. The redox potential was found to be better correlated with the disinfecting property of the water than was the amount of available chlorine. For individual pure chlorine compounds, the measuring of available chlorine showed in general a somewhat better correlation with reduction of the bacteria than the redox potential showed.


Clindamycin serum concentrations after administration of clindamycin palmitate with food.


Birth order and the military: a review from an Adlerian perspecttive.


Selective attention and social interest.


A bioavailability study on three oral preparations of the combination trimethoprim-sulfamethoxazole.


Thirth days with Alfred Adler.

Thirth days with Alfred Adler.


Edward Woakes: the history of an eponym.


Skin flaps in head and neck surgery.

Skin flaps in head and neck surgery.


A double-blind comparison of sulpiride with chlorpromazine in chronic schizophrenia.


Nefopam hydrochloride: a novel muscle relaxant.


An electron microscope technique for measuring the distribution of ribosomes and polysomes in cardiac ribosomal preparations.


A clinical evaluation of flurazepam.

A clinical evaluation of flurazepam.


Progestogen therapy for ovarian carcinoma.


The metabolism of indomethacin in man.

The metabolism of indomethacin in man.


Applied plaster impressions for maxillary complete dentures.


A clinical investigation of composite resin restorations in anterior teeth.


Combined use of subperiosteal implant and bone-marrow graft in deficient edentulous mandibles: a preliminary report.


Achieving planned parallel guiding planes for removable partial dentures.


Acrylic resin display casts.

Acrylic resin display casts.


A technique for transfer of coping relationships.


Medical traditions in Malaysia.

Medical traditions in Malaysia.


Shall we continue using hexachlorophene?


Blue Shield and fiscal intermediaries.

Blue Shield and fiscal intermediaries.


Idiopathic scoliosis. Current concepts in the treatment.


Dr. Carl C. Chatterton and Gillette Children's Hospital.


Immigrant radiologist of Canadian and non-American origin.


The introduction of an artificial lens into the eye using Binkhorst's technique.


Regulatory mechanism of the tryptophan operon in Escherichia coli: possible interaction between trpR and trpS gene products.


Bone formation and resorption as a requirement for marrow development.


Hemodynamic changes in systemic tuberculin reaction, active anaphylaxis and shock caused by histamine-serotonin or endotoxin.


The use of inhibitors in the study of picornavirus genetics.


Experimental chondrolysis. An immunofluorescent and autoradiographic study.


In memoriam. Israel Targowsky.

In memoriam. Israel Targowsky.


Genetic and immunological complexity of major histocompatibility regions. There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.


Retinitis pigmentosa: a review.

Retinitis pigmentosa: a review.


Tumor-inhibitory effect of antiplasma cell serum.


Non-specific and specific immunotherapy in patients with melanoma.


Pyridoxine dependency and central nervous system excitability.


Pyridoxine, DOPA, and Parkinsonism.

Pyridoxine, DOPA, and Parkinsonism.


The antivitamin B 6  effect of penicillamine: clinical and immunological implications.


The possible role of gamma-aminobutyric acid in the synthesis of protein.


The role of pyridoxal 5'-phosphate in the structure and function of glycogen phosphorylase.


Nature and roles of receptor sites for amino acid transport.


Some interrelationships of pyridoxal phosphate, folic acid, and serine metabolism in brain.


Postsecondary programs for deaf students in 1972.


The effect of neuropharmacological agents on metabolism of vitamin B 6  in brain.


Candidal osteomyelitis and arthritis in a neonate.


The rate of bacteriologic response to antimicrobial therapy in neonatal meningitis.


Naturally occurring canine glomerulonephritis. The 8 dogs with glomerulonephritis in this study had progressive renal disease characterized by proteinuria, azotemia and hypoalbuminemia, without peripheral edema and ascites. Observed by light, fluorescence and electron microscopy, the glomeruli were diffusely but irregularly involved. By light microscopy, there was focal mesangial proliferation, and the peripheral portions of many glomerular capillary loops were thickened by eosinophilic material along the endothelial sides of basement membranes. Immunofluorescence studies demonstrated granular deposits of IgG and beta1C-globulin outlining glomerular basement membranes and within the mesangium. Ultrastructurally, there were electron-dense deposits in the mesangium and within the endothelial side of glomerular basement membranes. Subepithelial deposits were never seen. The majority of clinical and morphologic features suggested a glomerulonephritis of immune-complex type. However, the unique aspects of the ultrastructural lesion precluded this assumption based solely on morphologic criteria.


Granular ependymitis. Occurrence in myxovirus infected rodents and prevalence in man. Intracerebral inoculation of neuropathic and nonneuropathic strains of mumps virus into adult hamsters resulted in an acute focal infection of ependymal cells followed by focal ependymal denuding. Similar lesions followed defective infection with influenza A in both hamsters and mice; when a large amount of influenza A was inoculated, aqueductal stenosis and hydrocephalus developed in some adult animals as a sequela of widespread ependymal cell loss. A survey of 100 consecutive adult human brains showed that 65% had granular ependymitis which had many of the characteristics found in the focal ependymal lesions produced in rodents. These studies suggest that human CNS mumps infections may produce granular ependymitis.


Alterations in antibody response induced by chronic inhalation of SO 2  and carbon.


Computer-assisted interview of patients with functional headache.


Plasmapheresis with plasma exchange in hepatic coma. II. Fulminant viral hepatitis as a systemic disease.


Treatment of progressive vaccinia. Use of methisazone, vaccinia immune serum globulin, and surgical debridement.


Early abortion and Mycoplasma infection.


Phenoxybenzamine in kidney preservation for transplantation.


Resurfacing of burns with preserved skin.


Proton relaxation and kinetic studies of ternary complexes of an allosteric pyruvate kinase from yeast.


Characterization of colicin Ia and colicin Ib. Chemical studies of protein structure.


Conformational changes in aspartate transcarbamylase. IV. Ligand effects on intersubunit interactions.


Subunit structure and binding properties of three amino acid transfer ribonucleic acid ligases.


Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast.


The sequence of SCMK-B2B, a high-sulfur protein from wool keratin.


Mechanism of assembly of the outer membrane of Salmonella typhimurium. Isolation and characterization of cytoplasmic and outer membrane.


Amino acid sequences around the two  -N-trimethyllysine residues in rabbit skeletal muscle myosin.


Benjamin Rush: physician in politics.

Benjamin Rush: physician in politics.


On the biosynthesis of insulin in anglerfish islets.


Books as clinical tools. Annotated book list for practicing physicians (1972).


Precision stereotaxic equipment.

Precision stereotaxic equipment.


A simple method for obtaining autoradiographs of single isolated neuroglial cells.


An in vitro technique for the study of hypothalamic control of gonadotrophin secretion in the sheep.


Combined neurovascular pedicle and cross finger flap in thumb and index finger: a case report.


An enquiry into the nature of the mediator of the vasodilatation in skeletal muscle in exercise and during circulatory arrest.


In vivo fabrication of a temporary prosthesis for maxillofacial avulsion wounds: a clinical trial in Vietnam.


The continuous bacteremia of lepromatous leprosy.


Surgical management of chronic obstructive lung disease.


Replication of the DNA of the colicinogenic factor E 1 (Col E 1 ) at the restrictive temperature in a DNA replication mutant thermosensitive for DNA polymerase. 3.


Linear sequence of proteins of Escherichia coli 50S ribosomal particles.


Repair of thermally induced DNA breakage in Escherichia coli.


Morton Baker, M.D. 1913-1972.

Morton Baker, M.D. 1913-1972.


The value of bisacodyl tannex (Clysodrast) in the radiological examination of the colon.


Synthetic polypeptide antagonists of the hypothalamic luteinizing hormone releasing factor. Two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine-2 position were tested for biological activity (secretion of luteinizing hormone) in cultures of dispersed rat anterior pituitary cells. The analog in which glycine was substituted for histidine at position 2, [Gly(2)]LRF, behaves as a partial agonist releasing less than 50 percent of the luteinizing hormone secreted at maximum concentrations of the releasing factor, while the analog in which histidine at position 2 is deleted has no significant agonist activity at any of the doses tested. When added to the cultured cells at molar ratios 10(3) to 10(4) times that of the luteinizing hormone releasing factor, both analogs decrease the amount of luteinizing hormone secreted in response to the releasing factor.


Effects on humans of   9 -tetrahydrocannabinol administered by smoking. Twelve chronic marijuana users received triangle up(9)-tetrahydrocannabinol by smoking. The magnitude of their pulse increment was highly correlated with their subjective experiences. Three of the 12 subjects subsequently received triangle up(9)-tetrahydrocannabinol labeled with carbon-14; the time course of its concentration in plasma was highly correlated with the pulse increment. Subjective symptoms, however, appeared later and dissipated more slowly.


Cholera.

Cholera.


Spontaneous tranformation of human brain cells grown in vitro and description of associated viurs particles. A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.


Summary of recent abstracts. 3. Malaria.


Summary of recent abstracts. 3. Malaria. 2.


A surgical legacy.

A surgical legacy.


Conspiracy and the American Medical Association.


Medicare--part B; surgical procedures, radiologists, pathologists and anesthesiologists.


Calibrated hypoxemia test in normal subjects and coronary patients. I. Hemodynamics and acid-base equilibrium in hypoxemia of short duration.


Further experiences with kidney preservation for 24 hours using continuous hypothermic perfusion. Renal clearances in pigs with autotransplanted preserved kidneys.


Effects of intravenously administered digoxin on mild left ventricular failure in acute myocardial infarction in man.


Right to left shunt in patients with acute myocardial infarction. A proposed mechanism.


Serial electrocardiographic changes in myocardial infarction.


Mitral regurgitation measured by continuous infusion of  133 xenon. An evaluation of the method in 91 patients.


Simon Samuel (1867) on inflammation. I.

Simon Samuel (1867) on inflammation. I.


Microcirculation and coronary blood flow.


Nutritional potential of nitrogen recycling in man.


Yerakon in the Bible and Talmud: jaundice or anemia?


Airway closure and lung volumes during breathing with maintained airway positive pressures.


Biochemical assessment of the nutritional status of vitamin B 6 in the human.


Crawford Long of Athens-Jefferson, Georgia.


Heterogenous transplant (Kiel bone) for the operative treatment of scoliosis.


Malaria and other diseases in Baedeker's guidebooks. I.


The headache in history, literature, and legend.


Jonathan Swift on madness and innovation.


The nature of antiplatelet activity in antilymphoblast ALG--with special reference to cross-reacting antibody, immunochemical characterization, and Coombs' positive thrombocytopenia in ALG-treated renal recipients.


Immunoglobulin levels and antibody to Candida albicans in human cervicovaginal secretions.


Gastric parietal cell autoantigen. Physical, chemical and biological properties.


Effects of 4-chlorotestosterone acetate on the phagocytic activity of human monocytes. Results of a double-blind trial.


Lymphocyte activation. 3. Binding sites for phytomitogens on lymphocyte subpopulations.


Renin and control of arterial blood pressure during terminal renal failure treated by haemodialysis and by transplantation.


Water and sodium excretion after blood volume expansion under conditions of constant arterial, venous and plasma oncotic pressures and constant haematocrit.


The outlook for the child with a myelomeningocele for whom early surgery was considered inadvisable.


Co-trimoxazole and cephalexin. A clinical trial in urinary tract infections in children with spina bifida cystica.


Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Reassessment of the ;gastric bactericidal barrier' to enteric bacteria in man included studies of the bactericidal activity of (1) the normal and achlorhydric stomach in vivo and (2) normal and achlorhydric gastric juice and other media in vitro. Within 30 minutes virtually all bacteria (Serratia marcescens) were eliminated in the normal stomach whereas no reduction occurred in the achlorhydric stomach in one hour. In vitro, identical bactericidal activity was observed at the same pH (from 2.0 to 7.0) in normal gastric juice, achlorhydric gastric juice, aqueous HCl, and nutrient broth. At pH less than 4.0, 99.9% of the bacteria were killed within 30 minutes. The presence of profuse bacterial flora, including coliforms, found in markedly acid-deficient but not in normal stomachs, correlates well with the absence of bactericidal activity. Thus, the ;gastric bactericidal barrier' is primarily pH-hydrochloric acid dependent, with other constituents of gastric juice contributing little, if any, detectable effect on the destruction of microorganisms.


Azathioprine in ulcerative colitis.

Azathioprine in ulcerative colitis.


An immunological study of adult coeliac disease.


A double blind trial of carbenoxolone sodium (duogastrone) in duodenal ulcer therapy with endoscopic diagnosis and follow up.


The control of pancreatic secretion.

The control of pancreatic secretion.


Sensitivity of Escherichia coli to viral nucleic acid. IV. Transfection of phage DNA to mutant thermosensitive in wall synthesis.


Construction of 30S particles from ribosomal proteins and 23S particles induced by ultraviolet light.


Remembrance of former things.

Remembrance of former things.


Effects of cast-gold mandibular dentures on the vertical dimension of rest position.


The cusp angles of artificial mandibular first molars.


Immediate removable partial dentures.

Immediate removable partial dentures.


Lateral translatory movements of the mandible: critical review of investigations.


The physiologic basis for the overlay denture.


Accuracy of pouring mercaptan rubber impressions at various intervals after separation.


Treatment of cleft lip and palate patients.


Report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.


Cryptococcal prostatitis in a patient with sarcoidosis: response to 5-fluorocytosine.


Abdominal surgery in cancer patients without wound complications.


Revascularization of the aortio-ilio-femoral trunk.


The serodiagnosis of significant genitourinary candidiasis.


J. A. Campbell Colston 1886-1971.

J. A. Campbell Colston 1886-1971.


Gentamicin and kidney transplantation: an assessment in vitro and in vivo.


The diagnosis of renal transplant rejection in association with acute tubular necrosis using the scintillation camera.


One-stage urethroplasty: 4-year followup.


Self-emasculation.

Self-emasculation.


Urine culture: search for an effective office screening technique.


A new concept in the treatment of stomal stenosis.


Cavernospongiosum shunt in the treatment of priapism.


Kidney autotransplantation for the treatment of renal artery stenosis: report of two cases.


Refinements in criteria for the determination of death: an appraisal. A report by the Task Force on Death and Dying of the Institute of Society, Ethics, and the Life Sciences.


The care of destitute children some nineteenth century practices in Australia.


Drug usage in the irritable colon syndrome.


Aesthetic plastic surgery. Development and place in medical practice.


President's address.

President's address.


Addiction and Edgar Allan Poe.

Addiction and Edgar Allan Poe.


Causes and treatment of non-ketotic hyperosmolar coma.


Microscopic diagnosis of eight testicular tumors.


The Devonshire colic: an 18th century mystery.


Rhinoplasty. Its development and present day usages.


Sensitivity of monomeric and dimeric forms of E. coli thymidine kinase to ultraviolet radiation.


Inhibition of the mixed lymphocyte reaction by antibodies.


Lymphocyte activation in allograft recipients.


Cell proliferation within graft and in blood during renal allograft rejection.


Studies of skin allograft survival and mixed lymphocyte culture reaction in Hl-A-genotyped families.


Effect of immunization by renal allografts on mixed lymphocyte and mixed skin-leukocyte reaction: a preliminary report.


Cellular reactivity studies in human and experimental renal transplantation.


The inhibitory effect of alloantisera on leukocyte migration in the rat.


A study of cell-mediated immunity to transplantation antigens in human renal allograft recipients.


Hyperacute rejection of heterotopic heart allografts in dogs.


Circulating antibody following cardiac transplantation in Ag-B-compatible rats.


The study of the psychiatric symptoms of systemic lupus erythematosus.. A critical review.


Experience with passive enhancement of renal allografts in A (DA x Lewis)F 1  to Lewis Strain combination.


Passive enhancement of kidney allografts: potentiation with antithymocyte serum.


Adrenalectomy and orchidectomy as immunopotentiating procedures.


Demodectic mange in dogs immunosuppressed with antilymphocyte serum.


Transplantation of malignant melanoma with cadaver kidney.


Humoral and cellular factors in xenograft rejection by mice.


The use of acetone-dried thymus powder for the production of antithymocyte serum.


Prolongation of skin graft survival by administration of purified phytohemagglutinin.


Extracorporeal irradiation of the blood and corneal transplantation. A survey with a report of the first case.


Organ transplantation in the rat. The importance of the Ag-B (or H-1) locus.


Electron microscopy of staphylococcal protein A reactivity and specific antigen-antibody reactions.


Further observations on the ultrastructure of Treponema pallidum nichols.


Ewald William Busse, M.D. One hundredth president, 1971-1972.


Lithium response in unipolar versus bipolar depression.


The use of doxepin in the treatment of symptoms of anxiety neurosis and accompanying depression: a collaborative controlled study.


Comparison of injectable haloperidol and chlorpromazine.


Influence of acetyl- -methylcholine, carbamoylcholine, and bis-pyridinium compounds on the activity of acetylcholinesterase.


States of tyrosine residues in L-asparaginase: the existence of tyrosine residues having abnormally low pK in L-asparaginase.


Action of yeast proteinase C on synthetic peptides and poly- ,L-amino acids.


Two part dentures with precision attachments.


Bacteriocins of the phytopathogens Pseudomonas syringae, P. glycinea, and P. phaseolicola.


The organisms and biological processes involved in asymbiotic nitrogen fixation in waterlogged soil amended with straw.


Comparison of the kinetics of thiosulfate oxidation by three iron-sulfur oxidizers.


Distribution of Clostridium botulinum type E in the Gulf of St. Lawrence in relation to the physical environment.


Physiological and morphological effects of phenethyl alcohol upon a gram-negative marine pseudomonad.


Susceptibility of the Mongolian gerbil (Meriones unguiculatus) to Western equine encephalitis.


A study of thermophilic aerobic sporeforming bacteria isolated from soil and water.


A reliable platinum electrode for intravascular ascorbate dilution studies.


Immunoglobulins and anti-immunoglobulin factors in psoriatic lesions.


The influence of cyclophosphamide on the rejection of allogenic rat kidney transplants. An in vitro study of cell-bound and antibody-mediated immunity.


Antibody affinity. 3. The role of multivalance.


Ethanol-induced acute esophageal motor dysfunction.


Thermal and conductivity dilution curves for rapid quantitation of pulmonary edema.


Effect of drugs, hypoxia, and ventilatory maneuvers on lung diffusion for CO in man.


Effect of anabolic steroids on reflex components.


Blood affinity for oxygen in hemorrhagic and endotoxic shock.


Taurine and isethionic acid: distribution and interconversion in the rat.


Effect of diet on glucose entry and oxidation rates in ponies.


A conspectus of research on vitamin A requirements of man.


A historical review of diabetes and pregnancy.


The none-too-cordial-host.

The none-too-cordial-host.


Chronic cigarette smoking. Effect on adrenocortical and sympathoadrenomedullary activity in man.


Long term (15 days) incubation of islets of Langerhans isolated from adult rats and mice.


Cytopathology of Newcastle disease. The influence of bursal and thymic lymphoid systems in the chicken.


Abdicate not from this responsibility.

Abdicate not from this responsibility.


Indications for penetrating keratoplasty.


Current trends in pituitary surgery.

Current trends in pituitary surgery.


Prevention and treatment of progressive secondary hyperparathyroidism in advanced renal failure.


The effects of ethanol on cortical and subcortical electrical activity in cats.


The effects of route of antigen administration on the induction of delayed skin reactivity and antibody in rats.


Postoperative hemobilia.

Postoperative hemobilia.


Insensitivity of the Ehrlich tumor in BALB-c mice to treatment with Escherichia coli T2 bacteriophage.


Management of flail-chest injury.

Management of flail-chest injury.


Inhibition of gastric and duodenal proteases in the treatment of haemorrhage from peptic ulcer. I. An experimental study of bentonite and other protease inhibitors.


Radioactive tracers in diagnosis of cardiovascular disease.


Some technical modifications in oesophageal resection for carcinoma.


Lung fibrosis in ankylosing spondylitis.


Immunological control in lung transplant.


Functional problems of lung transplantation.


Operative technique for lung transplantation.


Lung postoperative care.

Lung postoperative care.


Pathological findings following lung transplantation.


Vaccination against Escherichia coli enteritis in pigs.


Serum IgM in diagnosis of infection in the newborn.


House dust mites and allergy.

House dust mites and allergy.


Infantile cortical hyperostosis with lytic lesions in the skull.


The strength of metal-ceramic bonds with base metals containing chromium. A preliminary report.


Dentistry a hundred years ago. Charles James Fox--the forgotten man.


Hyaline membrane disease: the era of CPAP, CNP and PEEP.


Experimental studies on a new anti-inflammatory agent of non-steroid group, "DA-398", and its clinical experiences in oral surgery.


The first decade. The story of the birth of Canadian Medicare in Saskatchewan and its development during the following ten years.


Burbulence (indigestion due to gas).

Burbulence (indigestion due to gas).


Metampicillin. Antibacterial activity and absorption and excretion in man.


Antimicrobial activity of 5-nitro-2-furaldehyde-N'-methyl-N-piperazinoacethydrazone, a new hydrosoluble nitrofurane derivative. I. In vivo antibacterial activity.


Principles of methodical studies on capillaries in the light of the immunomorphogenesis of the capillary-haemopoietic system. II. Experimental and clinical studies.


The addition of lac+ chromosome fragments to the E. coli proA-proB-lac deletion 13 chromosome. Escherichia coli with the proA-proB-lac deletion X111 (Delta111) can be transduced with bacteriophage P1 propagated on a wild-type lac(+) donor. Though the donor lac(+) genes cannot be integrated by replacement of the recipient Delta111 marker, the transduction process has the characteristics generally associated with generalized transduction of bacterial genes. Transduction does not require P1 helper infection, is stimulated by UV irradiation of transducing particles, and does require homology between the donor lac(+) chromosome and the recipient Delta111 chromosome. Among transductants produced through multiple P1 infection, a minority of P1dl lysogens are present. But the majority of the transductants have unstable lac(+) units, designated lacV, which are without detected P1 gene content. LacV is tightly linked to the Delta111 locus. Instability of lac(+) is eliminated when a recombination deficiency is introduced through a substitution of recA1 for rec(+). The properties of the Delta111/lacV strains are attributable to a chromosome in which lac(+) is situated between units of a genetic duplication beside the Delta111 locus. To explain the formation of partially diploid chromosomes we suggest that chromosome fragment integration is sometimes accomplished through a single aberrant recombination, a fusion of genetically heterologous DNA ends, and a single legitimate crossover.


Psychiatrists' attitudes toward the aged and aging.


Laboratory diagnosis of cholera during the Jerusalem outbreak, August-September 1970.


The epidemiology of neural tube defects.


Hydroxyurea and cell death.

Hydroxyurea and cell death.


Transformations of antibiotics. II. Transformation of antimycin A by hog kidney acylase.


Antibiotics in acute osteomyelitis in children.


Spinal osteotomy for severe kyphosis in children with myelomeningocele.


Ivar Alvik. 1905-1971.

Ivar Alvik. 1905-1971.


Raymond William Linton Calderwood. 1919-1971.


What no one knows, though everyone should, about IPPB machines. 3. Bird.


Gonzalo Lafora. (1897-1971).

Gonzalo Lafora. (1897-1971).


Induced chromosomal aberrations: biological and clinical significance.


Biochemical studies and therapy in subacute necrotizing encephalomyelopathy (Leigh's syndrome).


Corticosteroids in the treatment of infectious mononucleosis. An assessment using a double blind trial.


Myofilaments and cross bridges as demonstrated by freeze-fracturing and etching.


Effect of tricomplex fixation on lung tissue.


Ultrasonic diagnosis of aortic aneurysms.


Concanavalin A binding material derived from a tissue culture medium.


Origin and development of the demarcation system in megakaryocytes of rat bone marrow.


Amphibian yolk platelet ultrastructure visualized by freeze-etching.


Prevention and treatment of sudden cardiac death.


Therapy of complicated arterial hypertension.


The management of Parkinson's syndrome.

The management of Parkinson's syndrome.


The present status of chemotherapy in dermatology.


Isolation of Nocardia asteroides from a pig.


In memoriam--William Lete Shearer.

In memoriam--William Lete Shearer.


Radiologic follow-up after lymphangiography. Evaluating effects of therapy.


A clinical evaluation of a proteolytic enzyme mouthwash on plaque and gingivitis in children.


Too many partials?

Too many partials?


Clinical study new short acting sulfanilamide (sulfacytine). Protocol 636-48.


In memoriam: William Frederick Nkomo.

In memoriam: William Frederick Nkomo.


Effect of minor and major tranquilizers on somatosensory evoked potentials.


Comparative metabolism of mecloqualone-2- 14 C in mice, rats, dogs and man.


Validation of jugular venous flow as an index of total cerebral blood flow.


Current status of monosodium glutamate.

Current status of monosodium glutamate.


Chaim Sheba (1908-1971).

Chaim Sheba (1908-1971).


Newer techniques of cerebral blood flow measurement.


Lumbo-sacral malformations and spina bifida occulta in a group of proto-historic Modoc Indians.


Nuclear magnetic resonance spectroscopic studies of biological membranes.


Freeze etching: a classical view.

Freeze etching: a classical view.


The structure and immunologic properties of basic proteins of myelin.


John Victor Hall Best.

John Victor Hall Best.


A study of extent of variation in daily counts of Candida albicans in saliva.


Obituary.

Obituary.


Some thoughts on full dentures.

Some thoughts on full dentures.


Optical properties and base pairing of E. coli 5S RNA.


Three kidney transplantations in a patient with primary hereditary hyperoxaluria.


George Edward Hall.

George Edward Hall.


Effect of freezing on the molecular weight of bacterial DNA.


Prevalence of Cryptococcus neoformans in Delhi Zoological Park and its recovery from the sputum of an employee.


The effect of tranquilizers on the oxidation of glucose by yeast cells.


Double blind clinical trial with rimactane in salvage cases of pulmonary tuberculosis.


Obituary. Professor Moshe Woolf (1878-1971).


Malaria in college students.

Malaria in college students.


Lithium use in nonmanic depressive conditions.


Gas chromatographic determination of riot-control agents.


Two modes of "curing" transmissible bacterial plasmids.


Host ranges of R factors.

Host ranges of R factors.


The relationship between filaments, killing and restoration in irradiated Escherichia coli strain B.


Methionine regulatory defects in Salmonella typhimurium arising from amber-suppressible mutations.


Effect of long-chain fatty acids on some trypanosomatid flagellates.


A mutant of Escherichia coli with a defect in energy metabolism.


Isolation and taxonomic significance of bacteriophages for non-proteolytic Clostridium botulinum.


Functional development of the interacting cells in the immune response. II. Development of immunocompetence to heterologous erythrocytes in vitro.


Non-smooth mutants of Salmonella typhimurium: differentiation by phage sensitivity and genetic mapping.


The pathogenesis of Aleutian disease of mink. II. Enhancement of tissue lesions following the administration of a killed virus vaccine or passive antibody.


The isolation and some physiochemical and biologic properties of the type 3 antigen of group B streptococci.


Synthesis of 1-hydroxy-L-proline and related cyclic N-hydroxyamino acids. Metabolic disposition of  14 C-labeled 1-hydroxy-L-proline in rodents.


Mixed thiolsulfonates and sulfonamides from polyfunctional mercaptans using trifluoromethyl thiosulfonates.


Clinical psychology in the Psychological Abstracts, 1927-1970.


Nucleoside peptides. 4. Synthesis of certain 1-(N-4-aminoacyl-4-amino-2,3,4-trideoxy- -D-erythro-hex-2-enopyranuronic acid)cytosine derivatives related to blasticidin S.


Inhibition by thiamine phosphates of thiamine uptake in Escherichia coli.


Recollections of the background of the study on thiaminase and thermostable thiamine-decomposing factor in Japan.


An evaluation of thermal dilution for obtaining serial measurements of cardiac output.


Design for positive pressure respirators.


Facial burns.

Facial burns.


E.N.T. case of the month.

E.N.T. case of the month.


Long-term effects of neonatal jaundice on brain function in children of low birth weight.


Continuous negative chest wall pressure in hyaline membrane disease: one year experience.


Vomiting in utero with intestinal atresia.


Is there a correlation between allergy and infantile pyloric stenosis?


Samuel Z. Levine.

Samuel Z. Levine.


Conversations with the author of  I Never Promised You a Rose Garden".


Endothelial projections.

Endothelial projections.


Holography, 1948--1971.

Holography, 1948--1971.


On automation of perimetry.

On automation of perimetry.


Antibiotic regimens in moderately ill patients with purulent exacerbations of chronic bronchitis.


A simple analogue computer for cardiac output determination by thermodilution.


Effect of monoamine oxidase inhibitors on metabolism and in vivo release of H 3 -norepinephrine from the hypothalamus.


The use of ferritin-conjugated antibodies in electron microscopy.


Intrapericardiac aortopulmonary anastomosis.


Fifty-two years' experience with coronary artery disease: developmental understanding, treatment, and future connotations.


Urea amidolyase. I. Properties of the enzyme from Candida utilis.


L-asparaginase from Escherichia coli B. Chemical modifications of tyrosyl residues.


Effect of cathepsins D from normal and malignant tissues on synthetic peptides.


A spectrophotometric investigation of the pepsinogen-pepsin conversion.


The histidine-binding protein J is a component of histidine transport. Identification of its structural gene, hisJ.


The obsessive-compulsive neurosis: review of research findings.


Purification and properties of a component of histidine transport in Salmonella typhimurium. The histidine-binding protein J.


Mercer's Hospital 1734-1972.

Mercer's Hospital 1734-1972.


The primary structure of ovine luteinizing hormone. II. The amino acid sequence of the reduced, S-carboxymethylated A-subunit (LH- ).


Richard Francis Jones, B.S., M.D., 1897.


A laser flying spot scanner for use in automated fluorescence antibody instrumentation.


Myoid cells in the human foetal thymus.

Myoid cells in the human foetal thymus.


Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices.


Drug abuse screening programs: detection procedures, development costs, street-sample analysis, and field tests.


Adaptability of computer graphics to studies of atherosclerosis pathogenesis.


Reversible dissociation of L-asparaginase of Escherichia coli B.


Effect of an anticholinergic agent on riboflavin absorption in man.


Biotransformation of salicylic acid to its acyl and phenolic glucuronides in man.


A morphometric study of the Müller cell cytoplasm in the rat retina.


Ultrastructural cation precipitation in frog skeletal muscle. I. Localization of pyroantimonate precipitate at rest and in tetanus.


Ultrastructural studies on prostatic involution in the rat. Evidence for focal irreversible damage to epithelium, and heterophagic digestion in macrophages.


Intramitochondrial lamellar formations induced by pregnenolone-16- -carbonitrile in the hepatocytes of pregnant rats.


The formation of 'giant' mitochondria in the fibrillar flight muscles of the house fly, Musca domestica L.


Fiber ultrastructure and dimensions in thin-sectioned chromatin.


Ultrastructural morphology of the nucleolar organizing region.


Human sperm head ultrastructure: a freeze-etching study.


Micropapillae: a local modification of the cell surface observed in rabbit oocytes and adjacent follicular cells.


Molecular organization of the kinetoplast DNA of Trypanosoma cruzi treated with berenil, a DNA interacting drug.


Tubular systems of Limulus myocardial cells investigated by use of electron-opaque tracers and hypertonicity.


Electron microscopy of DNA-containing plasms. IV. Glutaraldehyde-uranyl acetate fixation of virus-infected bacteria for thin sectioning.


Arne Tiselius. 1902-1971.

Arne Tiselius. 1902-1971.


Administration, stream standards, and surveys.


Industrial wastes. Meat-, fish-, and poultry-processing wastes.


Paper and allied products.

Paper and allied products.


Agricultural wastes.

Agricultural wastes.


Tannery wastes.

Tannery wastes.


Textile waste.

Textile waste.


Steel industry.

Steel industry.


Petroleum-processing wastes.

Petroleum-processing wastes.


Solid waste composting.

Solid waste composting.


Plating and cyanide wastes.

Plating and cyanide wastes.


Industrial solid waste management.

Industrial solid waste management.


Dairy wastes.

Dairy wastes.


Chemicals and allied products.

Chemicals and allied products.


Radioactive wastes.

Radioactive wastes.


Mechanical and physical aspects of water pollution by oil spillage.


Ecological effects of oil pollution..

Ecological effects of oil pollution..


Spillage of hazardous polluting substances.


Water pollution. Freshwater macroinvertebrates.


Microbiology of water.

Microbiology of water.


Microbiology of waste treatment.

Microbiology of waste treatment.


Microbiology--waterborne outbreaks.

Microbiology--waterborne outbreaks.


Microbiological pathogens in animals and their detection.


Microbiology--detection and occurrence of viruses.


Oxygen sag and stream self-purification.


Effects on surface waters.

Effects on surface waters.


Effects on groundwater.

Effects on groundwater.


Aquatic sediments.

Aquatic sediments.


Marine and estuarine pollution.

Marine and estuarine pollution.


Effects on freshwater fish.

Effects on freshwater fish.


Organics.

Organics.


Thermal effects.

Thermal effects.


Biological filters.

Biological filters.


Activated sludge.

Activated sludge.


Sludge treatment, utilization, and disposal.


Evaluation of facility operation.

Evaluation of facility operation.


Administration. Systems analysis.

Administration. Systems analysis.


Economics.

Economics.


Defective translation in RC -  cells.

Defective translation in RC -  cells.


Role of complement in induction of the allergic response.


Coding properties and nucleotide sequences of E. coli glutamine tRNAs.


Molecular basis for repressor activity of Q  replicase.


Speculations on structural relationships between the hypothalamic releasing factors of pituitary hormones.


Specific binding of the oestradiol-receptor complex to DNA.


Normal function of transplanted mouse erythrocyte precursors for 21 months beyond donor life spans.


Computer simulation of medical logic in clinical decision support system.


Jewish welfare in colonial times.

Jewish welfare in colonial times.


Automated histoquantitation studies of bone.


Sayer Walker, MD. (1748-1826), pioneer in the theory and treatment of functional nervous disorders.


Surgery between Hunter and Lister as exemplified by the life and works of Robert Liston (1794-1847).


Subcapsular fluid accumulation. A remediable cause of elevated vascular resistance during perfusion preservation of kidneys.


Life insurance perspectives for the living kidney donor.


Immunological detection of rat heart allograft rejection.


Complications in prolonged administration of antilymphocyte serum in the guinea pig.


Detection and treatment of canine cardiac rejection.


Cellular and humoral factors governing canine mixed lymphocyte cultures after renal transplantation. II. Cellular.


Cellular and humoral factors governing canine mixed lymphocyte cultures after renal transplantation. 3. Further studies with antibody.


Observations on repeated courses of antilymphocytic globulin on skin allograft survival in rats and the formation of antibody to antilymphocytic globulin.


Renal allograft rejection in the rat studied with  125 I-fibrinogen.


In vivo effects of concanavalin A. I. Immunosuppressive effects.


Nocardia asteroides associated with swine abortion.


Use of phase microscopy with vaginal smears to determine ovulation in the bitch.


A new depsidone from Aspergillus nidulans.


Patient preference for cylinder location in spectacle lenses.


A comparison between BC 105 and methysergide in the prophylaxis of migraine.


Microbiology of nosocomial infections.

Microbiology of nosocomial infections.


Evaluation of positive blood cultures. Guidelines for early differentiation of contaminated from valid positive cultures.


Treatment of status asthmaticus. A report of 70 episodes.


Regeneration of marrow tissue in chronic iron deficiency in postweanling rats.


The use of selected cytologic indices for evaluation of estrogenicity of synthetic compounds.


Anatomy of red cell damage by Plasmodium falciparum in man.


Multicentre survey of urinary tract infections in general practice. Clinical trial of single dose treatment with sulfametopyrazine (Kelfizine-W).


Mineralisation defects of the primary teeth in intra-uterine undernutrition. I. Results of a clinical investigation.


The rigidity of lingual bars. II. Design criteria.


Computer analysis of lymphocytes from cases with lymphadenitis and lymphocytic lymphoma.


Comparative observations on adrenergic innervation and monoamine content in endocrine pancreas of some amphibians, reptiles and birds.


The cytogenetic diagnosis of malignancy in effusions.


In vitro initiated secondary anti-hapten response. 3. Separable roles of hapten and carrier in immune paralysis.


Biosynthesis of terpenes and steroids. 8. The synthesis and metabolism in Saccharomyces cerevisiae of ergosta-7,22,24(28)-trien-3 -ol.


The interrelationships of the pancreatic enzymes.


The appearance and distribution of vaginal antigen during the differentiation of the cervicovaginal epithelium in normal and estradiol-treated mice.


Conservation in head and neck surgery.

Conservation in head and neck surgery.


Fertilization of the mouse oocyte: sequence and timing of nuclear progression to the two-cell stage.


Chemosterilization of adult Rhodnius prolixus by metepa.


Scurvey as an occupational disease. XII. Scurvy in the early American Colonies.


Survey of the oral status of complete denture patients.


Surface tension in retention of complete dentures.


A new approach to partial denture design for unilaterally remaining lower teeth.


Effect of jaw malrelations on dental practice.


Splints for supporting transplanted teeth.


Repairs of metal parts of removable partial dentures.


The porcelain press technique.

The porcelain press technique.


Oral perception and proprioception: a review of the literature and its significance to prosthodontics.


The mechanism of immunosuppression by RES blockade.


Factors influencing the function of the reticuloendothelial system in infections.


Factors influencing clasmatosis in vivo. II. Dynamics of cytoplasmic cell budding in the lymphoid organs of mice on primary immunization.


Autoradiographic evidence for the origin of cells constituting arterial intimal thickening in experimental cardiac allografts.


Cervical lymphadenopathy secondary to toxoplasmosis.


Court tells what to do when transplant involves a minor.


Diploma programs in nursing accredited by the National League for Nursing. School year: September 16, 1972-September 15, 1973.


Therapy conductive to healing of the human pulp.


A review of the erroneously labeled "mummification" techniques of pulp therapy.


Quantitative evaluation of oral topical analgesia.


Transport of magnesium by a repressible and a nonrepressible system in Escherichia coli. Wild-type cells of E. coli take up Mg rapidly when grown in media with high (10 mM) or with low (50 muM) concentrations of Mg. Previous work has provided evidence that a transport system for Mg in E. coli also functions for the uptake of Co. Mutants resistant to Co have now been found to possess a system for Mg uptake that is repressed by high concentrations of Mg in the growth medium, and does not function effectively for the uptake of Co. The rate of Mg uptake by such mutants increases at least 50-fold within one generation after a transfer from growth medium with high Mg to one with low Mg concentrations. We conclude that there are at least two systems for the uptake of Mg in E. coli. System I is nonrepressible and can catalyze the uptake of Co as well as Mg; it is present in wild type but not in Co-resistant mutants. System II is repressible and has little affinity for Co; it is present in both wild-type and mutant strains.


Reversibility of the tryptophanase reaction: synthesis of tryptophan from indole, pyruvate, and ammonia. Degradation of tryptophan to indole, pyruvate, and ammonia by tryptophanase (EC 4....) from Escherichia coli, previously thought to be an irreversible reaction, is readily reversible at high concentrations of pyruvate and ammonia. Tryptophan and certain of its analogues, e.g., 5-hydroxytryptophan, can be synthesized by this reaction from pyruvate, ammonia, and indole or an appropriate derivative at maximum velocities approaching those of the degradative reactions. Concentrations of ammonia required for the synthetic reactions produce specific changes in the spectrum of tryptophanase that differ from those produced by K(+) and indicate that ammonia interacts with bound pyridoxal 5'-phosphate to form an imine. Kinetic results indicate that pyruvate is the second substrate bound, hence indole must be the third. These results favor a modified mechanism for the multitude of tryptophanase-catalyzed reactions in which alpha-aminoacrylate, which functions as a common enzyme-bound intermediate in both synthetic and degradative reactions, is not released into the medium during the latter reactions, but is degraded to pyruvate and ammonia by sequential reversible steps via enzyme-bound intermediates.


Role of DNA polymerase I and the rec system in excision-repair in Escherichia coli. The DNA polymerase I-deficient mutant polA1 is shown to perform an increased amount of UV-stimulated repair synthesis relative to its pol(+) parent. In contrast, a recA recB double mutant is found to perform little detectable repair synthesis. Analysis of the density distribution of sheared DNA of the recA recB mutant reveals that none of the repair synthesis in this strain is in the large repair patches previously demonstrated by us in wild-type strains. These results are interpreted in terms of a model involving both DNA polymerase I and the rec system in the excision-repair process, with polymerase I performing an efficient short patch repair and rec system enzymes producing predominantly large patches of repair synthesis.


Sedimentation properties of yeast chromosomal DNA. Sedimentation analysis of nuclear DNA released from spheroplasts of the yeast Saccharomyces cerevisiae indicates that it has a number average molecular weight of 6.2 x 10(8). The chromosomal DNA molecules range in size from as small as 5 x 10(7) daltons to as large as 1.4 x 10(9) daltons. Based on these values and estimates of the total DNA content of the yeast nucleus, it is proposed that each yeast chromosome contains a single DNA duplex.


Low activity of  -galactosidase in frameshift mutants of Escherichia coli. 16 lac frameshift mutants induced by an acridine derivative, ICR-191D, in E. coli are leaky for beta-galactosidase activity. Activities of all mutants differ from each other and from the wild type in their stability to thermal denaturation. The leakiness is under ribosomal control, since it is strongly reduced by strA restrictive mutations and is restored by ram mutations that reverse restriction. Addition of streptomycin during growth has an effect similar to the presence of the ram mutation. These ribosomal alterations do not modify the thermal stability of the enzyme.It is suggested that the leakiness is due to an infrequent 2- or 4-base reading close to the frameshift mutation site. The possibility that not only the ribosome, but also the reading context in the messenger, plays a role in securing code fidelity is discussed.


Interaction of eukaryote elongation factor EF 1 with guanosine nucleotides and aminoacyl-tRNA. Evidence for two species of elongation factor 1 (EF 1(A) and EF 1(B)) from calf brain has been obtained by molecular sieve chromatography on Sephadex G-150. A high molecular weight form, EF 1(A), interacts with GTP to form an EF 1(A)-GTP complex. GDP also reacts with EF 1, but unlike the reaction with GTP, an EF 1(B)-GDP complex is formed that contains a lower molecular weight and labile species of EF 1. The results also indicate that EF 1(A)-GTP reacts with aminoacyl-tRNA to form an aminoacyl-tRNA-EF 1(B)-GTP complex. These results are discussed with regard to the role of EF 1 in aminoacyl-tRNA binding to ribosomes.


Location of ribosomal protein binding sites on 16S ribosomal RNA. The distribution of ribosomal protein binding sites on the 16S ribosomal RNA molecule has been analyzed by limited ribonuclease hydrolysis of RNA-protein complexes, as well as by the interaction of individual proteins with RNA fragments purified from partial enzymatic digests. Of the six 30S subunit proteins known to interact directly with 16S RNA, proteins S4, S8, S15, S20, and, probably, S13 bind within a fragment produced by T(1) RNase (12S RNA) that comprises some 900 nucleotides and covers almost the entire 5'-terminal half of the 16S molecule. A fragment of 500-600 nucleotides (8S RNA) that is contiguous with 12S RNA and arises from the 3'-terminal portion of the 16S molecule is believed to contain the binding site for protein S7. Protein S15 interacts specifically with a sequence of about 135 nucleotides (4S RNA) that derives from 12S RNA after more extensive hydrolysis. Protein S4, but none of the other ribosomal proteins, binds to a 500-nucleotide fragment (9S RNA), generated by pancreatic RNase, that lies at the 5'-terminus of 16S RNA and is completely overlapped by the 12S fragment. A preliminary map of the binding sites is presented.


Spatial arrangement of ribosomal proteins: reaction of the Escherichia coli 30S subunit with bis-imidoesters. The 30S ribosomal subunit of E. coli was treated with the bifunctional reagent bis-(methyl)suberimidate. Crosslinked ribosomal proteins were identified as bands with increased molecular weight after electrophoresis in polyacrylamide gels containing sodium dodecyl sulphate. The pattern of crosslinked products was altered when unfolded subunits were used. Free ribosomal protein was not crosslinked. Several of the crosslinked products were cleaved by ammonolysis to form the original monomeric protein constituents. The low yields of the reactions necessitated the use of radioactive proteins and auto-radiographic procedures. The crosslinked proteins were tentatively identified by coelectrophoresis of the radioactive ammonolysis products with carrier 30S protein in sodium dodecyl sulphate, and coelectrophoresis at pH 4.5 in buffers containing urea.


Genetic and physicochemical characterization of Escherichia coli strains carrying fused F' elements derived from KLF1 and F57. Although the two F' elements, F57 (carrying his(+)) and KLF1 (carrying leu(+)), cannot normally coexist in the same cell, crosses between RecA(-) strains of Escherichia coli carrying these two elements gave rise, at a low frequency, to progeny carrying both the his(+) and leu(+) markers in an extrachromosomal state. Genetic studies showed that the his(+) and leu(+) markers were now linked, and centrifugation studies of F' DNA isolated from these strains confirmed the presence of a new species of DNA molecule of altered size. It is proposed that the his(+) and leu(+) genes in these strains are covalently linked on a single "fused" F' element.


Indirect suppression of recB and recC mutations by exonuclease I deficiency. recB(-)and recC(-) strains of Escherichia coli K12 are recombination deficient and sensitive to ultraviolet light and the drug, mitomycin C. We have reported that sbcB mutations indirectly suppress all three phenotypes and result in the loss of exonuclease I. In this publication we report the occurrence of other mutations that lead to loss of exonuclease I and indirectly suppress mitomycin and UV sensitivity but not recombination deficiency. These mutations (called xonA) are cotransducible with his and closely linked with sbcB. Both sbcB and xonA mutant strains appear to have identical residual amounts of nuclease activity on single-stranded DNA. It is hypothesized that exonuclease I possesses a second activity other than its known ability to degrade single-stranded DNA from a 3'-OH terminus. Accordingly, sbcB mutations would alter the second activity while xonA mutations would not.


Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destruction of the medial preoptic area had no effect on 24-hr drinking rhythms.


Expression of ribosomal protein genes as analyzed by bacteriophage Mu-induced mutations. The organization of ribosomal protein genes and the gene (fus) for a protein chain elongation factor, EF G, in Escherichia coli were studied with a merodiploid strain that has an episome with genetic markers, ery(r), spc(r), str(r), and fus(r), and a chromosome with markers ery(s), spc(s), str(s), and fus(s). The ery locus determines a 50S ribosomal protein and the spc and str loci determine 30S ribosomal proteins. The phenotype of the diploid strain is sensitive to all of the four antibiotics, erythromycin (Ery), spectinomycin (Spc), streptomycin (Str), and fusidic acid (Fus). Analysis of antibiotic-resistant mutants induced by bacteriophage Mu in the diploid strain indicates that these four genes, and probably many other ribosomal protein genes linked to them, are transcribed as a single unit, and the direction of the transcription is in the order of ery, spc, str, and fus.


Molecular structure of the pyruvate dehydrogenase complex from Escherichia coli K-12. The pyruvate dehydrogenase core complex from E. coli K-12, defined as the multienzyme complex that can be obtained with a unique polypeptide chain composition, has a molecular weight of 3.75 x 10(6). All results obtained agree with the following numerology. The core complex consists of 48 polypeptide chains. There are 16 chains (molecular weight = 100,000) of the pyruvate dehydrogenase component, 16 chains (molecular weight = 80,000) of the dihydrolipoamide dehydrogenase component, and 16 chains (molecular weight = 56,000) of the dihydrolipoamide dehydrogenase component. Usually, but not always, pyruvate dehydrogenase complex is produced in vivo containing at least 2-3 mol more of dimers of the pyruvate dehydrogenase component than the stoichiometric ratio with respect to the core complex. This "excess" component is bound differently than are the eight dimers in the core complex.


Replication of bacteriophage M 13: inhibition of single-strand DNA synthesis by rifampicin. Synthesis of single-stranded DNA of bacteriophage M 13 is blocked by rifampicin. This inhibition is not observed in an Escherichia coli mutant possessing an RNA polymerase resistant to rifampicin. Since rifampicin stops single-strand synthesis faster than chloramphenicol, inhibition by rifampicin does not seem to result from a transcriptional block of protein synthesis, particularly in view of the long half-life of the messenger RNA for M 13. It is, therefore, concluded that the interaction of rifampicin with RNA polymerase directly affects single-strand DNA synthesis. Possible mechanisms are discussed.


The indirect fluorescent antibody test for experimental East Coast fever (Theileria parva infection of cattle). Evaluatin of dried blood samples as a source of antibody.


The effect of concurrent scrapie on louping-ill encephalitis in the mouse.


Replicating, convalently closed, circular DNA from kinetoplasts of Trypanosoma cruzi. When Trypanosoma cruzi are treated with Berenil, a trypanocide, their kinetoplast DNA contains an increased proportion of double-branched circular molecules. These replicating molecules have closed-circular template strands; their decrease in density when complexed by ethidium bromide in a cesium chloride gradient is proportional to the length of the replicated segments. Replication seems to be blocked at specific points, which are equidistantly spaced along the circular kinetoplast DNA molecules. Analysis of about 800 replicating forms showed that the lengths of the replicated branches are not distributed at random, but into several populations, which correspond to multiples of 15% of the total contour length of 0.5 mum. This distribution evokes a discontinuous replication process. The problem of whether kinetoplast DNA is synthesized by successive replication units, or whether and how Berenil might induce specific blocking of DNA replication, is discussed.


Studies on the survival of Salmonella typhimurium and Salmonella bovis-morbificans on soil and sheep faeces.


Inhibition of Salmonella typhimurium by fowl caecal cultures.


Avenzohar.

Avenzohar.


Velva Schrire. M.B., Ch.B., M.D., M.R.C.P. (Lond.), F.R.C.P. (Edin.), F.R.C.P. (Lond.).


Enzymic formation of polyisoprenol phosphate sugars.


Transplantation of allogeneic conjunctiva as a complement to allogeneic skin grafting when studying immunosuppressive procedures in the dog.


Abdominal wound dehiscence.

Abdominal wound dehiscence.


Evaluation of operative biopsy of periampullary tumours.


Diagnosis of malignant lymphoma at laparotomy disclosing intrahepatic cholestasis.


Jesse William Lazear.

Jesse William Lazear.


The father of gynecology (James Marion Sims).


Senator Lister Hill: statesman for health and patron of medical libraries.


Alcoholic myopathy, a critical review.

Alcoholic myopathy, a critical review.


Scanning electron microscopic study of the interior of Schlemm's canal in the human eye.


Cystoid bleb cryotherapy.

Cystoid bleb cryotherapy.


A sensitive method for measuring oxygen consumption.


Colorimetric assay of catalase.

Colorimetric assay of catalase.


An economical procedure for the preparation of L-( 35 S)methionine of high specific activity.


Purification of ten transfer ribonucleic acids from E. coli K-12 MO.


Heartburn of pregnancy. A continuation study.


Wilfred M. Musgrove.

Wilfred M. Musgrove.


Pteridine content of some methane- and methanol-oxidizing bacteria.


Natural antibody production in human tonsils.


Increased incidence of lymphomas in thymectomized mice--evidence for an immunological theory of aging.


A stimulant effect of anti-macrophage serum on antibody production.


Immunofluorescence of arginine deprived cells infected with adenovirus type 12.


Bacterial RNA synthesis in frog auricles after intraperitoneal injection of bacteria.


Cyclic disulfides. Their functions in health and diseases.


Effects of ionizing radiation on the capacity of Escherichia coli to support bacteriophage T4 growth. The loss in capacity of irradiated bacteria to support the growth of T4 phage has been studied for two strains, Escherichia coli B and E. coli B(s-1). Following a dose of 25 krads, the capacity is quite rapidly lost during postirradiation incubation so that after two hr of such incubation at 37 C only 12% remains in strain B and 3% in strain B(s-1). Evidence that capacity is lost in an all-or-none fashion was provided by two types of experiments: (i) a single-burst analysis of those cells which survived to give a burst, and (ii) an analysis of the regulation of an early phage enzyme. Several processes were examined to try to determine the cause of the loss in capacity. These were the ability of the irradiated and postirradiation incubated cells to respire, to allow phage adsorption and injection of phage deoxyribonucleic acid, to support the transcription and translation of an early gene, and to support replication of phage deoxyribonucleic acid. Of these processes, transcription and translation appeared to be the most closely associated with the capacity loss, although respiration was reduced to 50% after 2 hr.


Gene regulation in N mutants of bacteriophage lambda. Mutants (N(-)nin) of bacteriophage lambda in which the N gene product is not required for growth on wild-type Escherichia coli do not plate on recA bacterial mutants. Secondary mutants, selected for growth on recA, lie within the immunity region to the right of gene cI and appear identical to the cro mutants of Eisen et al. In an N(+) phage, a cro mutation causes enhanced and prolonged production of lambda exonuclease. N(-)cro phages make no detectable exonuclease, but show an increased rate of specific excision from lysogens and are excluded by P2 prophage. These properties, together with the ability to plate on recA, suggest that N(-)cro phages express genes to the left of N at a rate that is very low but higher than that for N(-)cro(+) phages. N(-)nin phages can integrate at the normal site on the bacterial chromosome, but specific excision from lysogens is immeasurably low.


Genetic and physiological studies of bacteriophage T5. 3. Patterns of deoxyribonucleic acid synthesis induced by mutants of T5 and the identification of genes influencing the appearance of phage-induced dihydrofolate reductase and deoxyribonuclease. Patterns of deoxyribonucleic acid (DNA) metabolism in nonpermissive cells infected with amber mutants representing 29 genes of T5 are reported. A group of 7 contiguous genes are essential for the synthesis of phage DNA, whereas 20 other genes, when defective, permit varying degrees of phage DNA synthesis. Two further genes are essential for complete transfer of phage DNA to host cells, and therefore indirectly do not permit the synthesis of phage DNA. The structural genes for an early T5 deoxyribonuclease and for T5 DNA polymerase, as well as a gene that affects the synthesis of dihydrofolate reductase, have been identified in the genetic map of T5.


Differentiation between technical and professional nursing--an annotated bibliography.


On the direction of reading of bacteriophage T4 gene 43 (deoxyribonucleic acid polymerase). Amber (am) mutants of the two closely linked sites, B22 and C125, in bacteriophage T4 gene 43 [deoxyribonucleic acid (DNA) polymerase] synthesize in the nonpermissive (su(-)) Escherichia coli host gene 43 products which are devoid of DNA polymerase activity, but which retain a 3'-exonuclease activity. Diethylaminoethyl-cellulose chromatographic analysis of DNA polymerase and deoxyribonuclease activities from extracts of su(-) cells infected with single- and double-am mutants of T4 gene 43 showed that the exonuclease activity which is observed with amB22 is not seen with double mutants carrying, in addition to amB22, am mutations which map to the clockwise side of the B22 site on the circular genetic map of T4. Similarly, am mutations which map to the clockwise side of the C125 site abolish the exonuclease activity which is observed with an am mutant (amE4335) of this site. It was concluded that in these double mutants termination signals to the clockwise side of amB22 and amE4335 are encountered before the amB22 and amE4335 signals during translation of the messenger ribonucleic acid from T4 gene 43. Thus, it seems that the T4 DNA polymerase is synthesized in vivo in a direction which corresponds to a counterclockwise reading of gene 43.


Some factors affecting the transient cylindrical diffusion of oxygen in an artificial capillary model and comparisons with in vivo data.


En face stripping of vascular endothelium.


Changing patterns in hospital infection.


Vitamin K and the newborn.

Vitamin K and the newborn.


Exchangeable potassium and the prediction of fat free body weight.


Adipose tissue cellularity and calorigenic response to norepinephrine in rats exposed to cold.


Perinatal undernutrition, postnatal growth, and pituitary growth hormone.


Unsaturated fatty acids in trout diets.

Unsaturated fatty acids in trout diets.


Iron and zinc absorption and metabolism in germfree rats.


The effect of vasopressin on the coronary circulation in normovolemic and hypovolemic dogs.


Incisional hernias. A comparison between midline, oblique and transrectal incisions.


Pulmonary function studies in Plasmodium falciparum malaria.


Prolonged alteration of lung mechanics in kyphoscoliosis by positive pressure hyperinflation.


Pancreatic-bronchial fistula.

Pancreatic-bronchial fistula.


Effects of antibodies on gametes and fertilization.


Isolation and characterization of a protease from Clostridium botulinum type B.


Antihormones and their use in studies of reproduction.


Role of immunology in the infertile human.


Antibodies in malignant disease.

Antibodies in malignant disease.


Suppression of puerperal lactation with an ergot alkaloid: a double-blind study. A double-blind trial was performed in 60 women to establish the effectiveness of an ergot alkaloid, 2-Br-alpha-ergocryptine (ergocryptine; CB 154), in suppressing puerperal lactation and to compare it with stilboestrol and a placebo. At the doses selected ergocryptine and stilboestrol were equally effective.


Clinical screening of epipodophyllotoxin VM26 in malignant lymphomas and solid tumours. Epipodophyllotoxin (VM 26; 4'-demethyl-epipodophyllotoxin-beta-D-thenylidene glucoside) has been proved, in clinical screening, to be able to induce apparently complete remissions and pronounced though incomplete regressions in Hodgkin's disease, reticulosarcoma, and bladder cancer, as well as incomplete regressions in lymphosarcoma. Apparently complete regressions of malignant pleural effusions have been obtained after giving this drug systemically. It has a notable toxic action on the bone marrow.


Differential diagnosis of genital ambiguity in the newborn.


Clinical aspects of abnormalities of the X and Y chromosomes.


Genetic aspects of gynecologic disorders occurring in 46,XX individuals.


Genetic disorders affecting genital development in 46,XY individuals (male pseudohermaphroditism).


Origin and clinical significance of twinning.


Present status and future trends in prenatal diagnosis of metabolic disorders.


Serratia arthritis of the hip. A case report.


Sites and modes of action of an estrogen-gestagen combination on calcium and phosphate metabolism in postmenopausal osteoporosis.


Current concepts of the crosslinking in bone collagen.


Mineral chemistry and skeletal biology.

Mineral chemistry and skeletal biology.


Current concepts of collagen structure.

Current concepts of collagen structure.


Studies on T4 lysozyme. Affinity for chitin and the use of chitin in the purification of the enzyme.


A model of bacterial flagella based on small-angle x-ray scattering and hydrodynamic data which indicated an elongated shape of the flagellin protomer.


Removal of non-neuronal cells from suspensions of dissociated embryonic dorsal root ganglia.


Incorporation of deoxythymidine triphosphate into DNA of fractions of mouse liver in vitro.


Effects of p-dl-fluorophenylalanine on mitosis and the mitotic spindle.


Somatic cell hybrids between cultured fibroblasts from the Galapagos tortoise and the golden hamster.


Mineral nutrition, calcium, phosphorus, magnesium, and potassium interrelationships.


Nature of the interaction between M protein of Streptococcus pyogenes and fibrinogen.


Temperature-sensitivity characteristics distinguishing substrains of fixed rabies virus: lack of correlation with plague-size markers or virulence for mice.


A new subunit influenza vaccine: acceptability compared with standard vaccines and effect of dose on antigenicity.


What no one knows, through everyone should, about IPPB machines.


Frameshift suppressors. II. Genetic mapping and dominance studies.


Characterization of the genome of the cellular slime mold Dictyostelium discoideum.


Evidence for a soluble protein factor specific for the interaction between aminoacylated transfer RNA's and the 40 s subunit of mammalian ribosomes.


Frameshift suppressors. 3. Effects of suppressor mutations on transfer RNA.


Quantitative electromyography: a new analogue technique for detecting changes in action potential duration. An automatic method using an analogue analyser is described for obtaining an index which is based on the mean phase duration of an EMG signal. This method gives similar values for motor unit action potential duration to an alternative digital method of analysis based on the distribution of time intervals between zero crossings of the EMG signal. The analysis has been found to give good discrimination of normal and myopathic EMG signals.


A fantastic craniotomy: excerpt from the 17th century Turkish travelogue of Evliyâ Celebi. Case report.


Anterior cervical discectomy without interbody bone graft.


Lymphomas of the gastro-intestinal tract.


An analysis of volume changes in the T-tubes of frog skeletal muscle exposed to sucrose. The volume responses of the T-system of frog skeletal muscle to isotonic solutions of altered ionic composition, as studied by electron microscopic examination of osmium-fixed tissue, have been re-investigated using aldehyde fixatives.1. In confirmation of the earlier work we find that the T-tubes swell in frog sartorius muscles which have been soaked in Ringer solution in which the sodium chloride concentration has been reduced to 40 mM and tonicity maintained with sucrose before fixation in osmium.2. The swelling does not occur in muscles similarly treated, but fixed with acrolein or glutaraldehyde.3. Swelling of the T-tubes, which has been reported for osmium-fixed muscle following exposure to Ringer in which chloride is replaced by acetate, or reduced and sulphate substituted, does not occur when fixation is by acrolein.4. Analysis of the data from the earlier work with sucrose substitution shows that the degree of T-tube swelling is proportional to the sucrose concentration of the soaking medium, whether the solution be isotonic or anisotonic.5. It is concluded that the increase in T-tube volume arises in muscles which have been exposed to certain impermeant solutes during fixation by osmium, and a possible mechanism to account for the effect is described.6. The relevance of these observations to the hypothesis that the sarcoplasmic reticulum is an extracellular compartment in muscle and to the proposal that the T-tubes may represent an intermediate compartment for potassium fluxes is discussed.


Medical education in Maryland in the eighteenth century.


Characterization and metabolism of free fatty alcohols from Escherichia coli.


Changes in fluid intake suggesting depressed appetite in rats with central catecholaminergic lesions.


Evidence of a sex-specific effect of testosterone and progesterone upon L-cystine-aminopeptidase activity in the hypothalamus and paleopallium of the rat.


Intrahypothalamic locus for induction of androgen sterilization in neonatal female rats.


Luteinizing hormone-releasing hormone (LH-RH) content in the hypothalamus of 65-day-old and 10-month-old male rats.


Purified diets for ruminants.

Purified diets for ruminants.


Lipogenic adaptations related to pattern of food intake.


Lactase activity levels in Nigeria--genetic or acquired phenomenon?


Effects of meal frequency during weight reduction.


Translocation of S 35  in Rhizopus stolonifer.


Cancer and albumin metabolism.

Cancer and albumin metabolism.


Some observations on the morphology of in vitro decalcified incipient enamel caries.


History of the South Dakota state Department of Health.


A bulb-pipette-grid combination for fluid processing of small specimens used for electron microscopy.


Paraffin embedding of bony tissues followed by decalcification of the layer to be sectioned.


Metabolism of phosphoglycerides in Escherichia coli during growth at 37 degrees C and during a cold-induced lag phase.


The careers and contributions of Eugene Rabinowitch.


Publications of Eugene Rabinowitch.

Publications of Eugene Rabinowitch.


Light scattering at various angles. Theoretical predictions of the effects of particle volume changes. The Mie theory of scattering is used to provide new information on how changes in particle volume, with no change in dry weight, should influence light scattering for various scattering angles and particle sizes. Many biological cells (e.g., algal cells, erythrocytes) and large subcellular structures (e.g., chloroplasts, mitochondria) in suspension undergo this type of reversible volume change, a change which is related to changes in the rates of cellular processes. A previous study examined the effects of such volume changes on total scattering. In this paper scattering at 10 degrees is found to follow total scattering closely, but scattering at 45 degrees , 90 degrees , 135 degrees , and 170 degrees behaves differently. Small volume changes can cause very large observable changes in large angle scattering if the sample particles are uniform in size; however, the natural particle size heterogeneity of most samples would mask this effect. For heterogeneous samples of most particle size ranges, particle shrink-age is found to increase large angle scattering.


Cleavage of bacterial flagellin with proteolytic enzymes. II. Induction of enhanced delayed-type hypersensitivity to flagellin by peptic fragments of the protein.


Evaluation of hypertensive patients.

Evaluation of hypertensive patients.


Treatment of Parkinson's disease with amantadine and L-Dopa.


Precision microbicannulation device for neuroendocrine or neurophysiologic applications.


Serum immunoreactive insulin and growth hormone response to potassium infusion in normal man.


Effect of salicylates on the gastric mucosal barrier in man.


Pulmonary gas exchange in dogs breathing SF 6  at 4 ata.


Differential sensitivity to hibernation of early and late events in development of the immune response.


Modification of the gelatin substrate procedure for demonstration of acrosomal proteolytic activity.


Relationship of the selective metastatic behavior of tumors of reticular tissues to the migration patterns of their normal cells of origin.


Ultrasonic measurement of blood flow changes in canine renal allografts.


Myocardial and adrenal medullary catecholamine responses. I. Response to rapid digitalization with acetylstrophanthidin.


Depression of growth in hyperactive children on stimulant drugs.


Immunosuppressive therapy. 1.

Immunosuppressive therapy. 1.


Doctors afield. Wakley of the Lancet.

Doctors afield. Wakley of the Lancet.


RNA synthesis startpoints in bacteriophage lambda: are the promoter and operator transcribed?


Reconstruction of Salmonella flagella attached to cell bodies.


Immunofluorescent identification of Streptococcus mutans.


Endogenous testosterone concentrations in rat testis interstitial tissue and seminiferous tubules during in vitro incubation.


The modern history of amputation surgery and artificial limbs.


Bernardo Alberto Houssay (1887-1971).

Bernardo Alberto Houssay (1887-1971).


Principles and practice in upper extremity prostheses.


Complications of lower extremity amputations.


Effect of fenfluramine on the single neuron activities of the hypothalamic feeding centers.


Gonadal hormones and behavioral regulation of body weight.


Locomotor activity increases produced by intrahippocampal and intraseptal atropine in rats.


An acute atraumatic stereotaxic headholder for cat.


Exocrine pancreatic insufficiency. Current concepts of pathophysiology.


Automated multitest laboratories--needs and potential.


Modification of enterosorption induced by a heat labile Escherichia coli enterotoxin in rabbit intestinal loops.


HSV-2 antigens absent from biopsied cervical tumor cells: a model consistent with latency.


Purified cobra venom factor: effect on blood platelets.


Microsomal pentobarbital hydroxylase activity in acute viral hepatitis.


Relative effect of thymocytes from irradiated donors on hemopoiesis in P-F 1  Chimeras.


Glomerular basement membrane damage in aminonucleoside nephrosis as visualized by lanthanum.


Reconstitution of the in vitro immune response of congenitally thymusless (nude) mice.


Laboratory procedures for potency testing of blastomycin, histoplasmin, and coccidioidin.


Methionine-selenomethionine parallels in E. coli polypeptide chain initiation and synthesis.


Immunotherapy of Friend disease in mice employing viable BCG vaccine.


Postconception development of rat ova following x-ray induced superovulation.


The effects of ionizing radiation on thymidine uptake into Escherichia coli B-r and Bs-1.


Effect of orally and intravenously administered stable strontium on  90 Sr metabolism in man.


The modification of the yields of single strand breaks in DNA of gamma-irradiated Escherichia coli.


Henry Alexander Blair. 1900-1971.

Henry Alexander Blair. 1900-1971.


Antoine Lacassagne (1884-1971).

Antoine Lacassagne (1884-1971).


Forty years' clinical chemistry in Scandinavia.


The role of transplanted slowly proliferating bone marrow cells for regeneration of lethally x-irradiated rat bone marrow.


Structural identification of thrombosthenin in rat megakaryocytes.


Post-traumatic pulmonary insufficiency syndrome.


Effects of atropine on the cardiorespiratory alterations of endotoxic shock in unanesthetized dogs.


Studies on lysozyme (muramidase). II. Serum and urine muramidase patterns in chronic uremia, chronic hemodialysis and renal allotransplantation.


Biosynthesis of the tripyrrole bacterial pigment, prodigiosin, by nonproliferating cells of Serratia marcescens.


The clinical significance of mitochondrial antibodies.


Spontaneous lymphocyte transformation in leucocyte cultures of children with falciparum malaria.


Distribution, state and translocation of Na and K in the retinal rod outer segments (a review).


The structure of poly 2'-O-methylcytidylic acid and its complexes with polyinosinic acid.


Oneiromancy: an historic review of dream interpretation.


Current status of infraclavicular subclavian vein catheterization.


A representation of mortality data by competing risks.


The use of non-parametric methods in the statistical analysis of the two-period change-over design.


The use of glycolytic metabolism in the assessment of hypoxia in human hearts.


Locomotion of human polymorphonuclear leucocytes.


A correlation of metabolic and flow responses of the left coronary system of man with coronary artery disease.


Effects of colchicine and high hydrostatic pressure on the nuclear position in onion root-tip cells.


Cell cycle of chondrocytes in vitro.

Cell cycle of chondrocytes in vitro.


Cardiac transplantation--cardiological problems.


Sir William Bowman (1816-1892).

Sir William Bowman (1816-1892).


Evaluation of a rat model for induction of pyelonephritis with cell wall deficiency variants of Proteus mirabilis.


The renin aldosterone relationship after renal allotransplantation in man. Renin and aldosterone after transplantation.


Renal preservation with a synthetic perfusion fluid.


Clinical diagnosis by the objective-analytic personality batteries.


Absolute and relative figure drawing size in institutionalized orphans.


Effect of osmolalities comparable to those of the renal medulla on function of human polymorphonuclear leukocytes.


Subacute sclerosing panencephalitis: in-vitro characterization of viruses isolated from brain cells in culture.


Effect of adjuvant on immunogenicity of a heat-killed salmonella vaccine.


The pathogenesis of shigella diarrhea. II. Enterotoxin-induced acute enteritis in the rabbit ileum.


Interbacterial transfer of R factor in the human intestine: in-vivo acquisition of R-factor-mediated kanamycin resistance by a multiresistant strain of Shigella sonnei.


Pulpal response to high speed cavity preparation using water or air spray as coolants.


Amniotic fluid composition in malformation of the central nervous sytem.


Hydramnios associated with congenital microstomia agnathia and synotia.


An editorial: progress in health education: 1939-1972.


Natural history of the ischemic heart disease, especially of the myocardial infarction.


William John Laurence Duncan.

William John Laurence Duncan.


Allan Bennie Wilson.

Allan Bennie Wilson.


The danger of putting a baby to bed in a large bed.


Thomas Morgan Rotch (1849-1914), America's first full professor of pediatrics: his contribution to the emergence of pediatrics as a specialty.


Joseph Stokes, Jr.

Joseph Stokes, Jr.


Fables for the instruction of youth published in Boston in 1818.


Listeriosis, royalty, and the British parliament.


Morbidity and mortality of infants weighing less than 1,000 grams in an intensive care nursery.


Central blockade of (methyl-)atropine on carbachol drinking: a dose-response study.


Reaction time and heart rate response pattern: effects of reticular stimulation in cats.


A simple procedure for making stereotaxic lesions in the mouse.


On a new method of staphylorrhaphy by Karl Schoenborn, M.D., Königsberg, Germany (Arch. für klinische Chirurgie, 19:527-531, 1876).


Methods of bone grafting the mandible.

Methods of bone grafting the mandible.


Ocular flutter.

Ocular flutter.


A microbiologic investigation of percutaneous central venous catheters.


Chemical evolution and the origin of life. Bibliography supplement 1970.


Ending the routine guinea-pig test.

Ending the routine guinea-pig test.


Of pigs and men and research: a review of applications and analogies of the pig, sus scrofa, in human medical research.


Melioidoses, pseudomonas pseudomallei and the clinical laboratory.


Physician input into the Medicare claims process.


Pre-Columbian American visitors and their influence on American medicine.


Suggested readings for parents of preschool deaf children.


Generalized hamartomatosis. (Copngenital generalized fibromatosis).


Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. Double-blind cross-over assessments.


Improved treatment of chronic pyelonephritis with nitrofurantoin in combination with deglycyrrhizinated liquorice.


Differences in fatty acid composition among phosphatidylethanolamine, phosphatidylglycerol and cardiolipin of Escherichia coli.


The mechanism of cardiolipin biosynthesis in liver mitochondria.


Morphogenesis in Aspergillus nidulans. The significance of a alpha-1, 3-glucan of the cell wall and alpha-1, 3-glucanase for cleistothecium development.


A new procedure for the synthesis of L-histidinol and its application in preparing L-[14C]histidinol.


Effect of hippocampal stimulation on the plasma thyrotropin (THS) and corticosterone responses to acute cold exposure in the rat.


Studies on the antigenicity of radiation-induced murine osteosarcomata. The immunogenicities of 15 murine osteosarcomata induced with a bone seeking radioisotope ((90)Sr) in normal and chimaeric CBA mice were studied. Attempts were made to induce tumour-specific immunity in syngeneic mice by treatment with x-irradiated (15,000 rad) tumour or surgical excision of developing subcutaneous tumour grafts. Resistance was evoked against 6 tumours and this was relatively weak. With the remaining tumours, no resistance against the immunizing tumour could be demonstrated, even though the transplantation tests were made highly sensitive by the use of inocula of as few as 2 × 10(3) cells in pre-irradiated (400 rad) hosts. Sera from mice immunized against each of the tumours were tested against viable cells of the immunizing tumour by indirect immunofluorescence. In no instance did tumour antisera give a convincing reaction with tumour cells although alloantisera raised by hyperimmunization of H-2 identical and H-2 different donors with osteosarcomata consistently gave strongly positive reactions. The results are interpreted as illustrating the weak tumour specific antigenicity of radiation-induced murine osteosarcomata. The possibility that antigenic deficiency is a consequence of immunosurveillance in this tumour system is discussed.


Effect of noradrenalin on brain nucleic acids and RNA-polymerase.


Tandem duplications of the rII region of bacteriophage T4D.


A histidine operator-constitutive mutation decreases the frequency of recombination within the histidine operon of Salmonella typhimurium.


Dietary gluten sensitivity updated.

Dietary gluten sensitivity updated.


Mitosis in heterobasidiomycetous yeasts. I. Leucosporidium scottii (Candida Scottii).


Fats and bile salts. II. Pathologic considerations.


Ephraim McDowell--the backwoods surgeon.


Centrifugation properties of sex pili.

Centrifugation properties of sex pili.


Cardiorespiratory effects of general anesthesia in outpatients: the influence of atropine.


Horizontal osteotomy for correction of maxillary retrusion: report of case.


Hemolysis in glucose-6-phosphate dehydrogenase deficiency.


Isoniazid and psuedocholinesterase polymorphisms.


A method of reconstruction from serial sections.


The yeast cell in anti-mitochondrial activity of drugs.


A master of neuro-histological technique.


Circulating humoral antibodies in cancer.


Law and medicine.

Law and medicine.


Prevention of bacterial growth and local infection in burn wounds.


Controlled cryotherapy in the treatment of inflammatory papillary hyperplasia.


Foreign bodies of dental origin in the esophagus.


Enlargement of salivary glands. Review of the literature.


The birth and growth of oral pathology.

The birth and growth of oral pathology.


Classification of pulpal pathosis.

Classification of pulpal pathosis.


Coding of sounds in lower levels of the auditory system.


The peripheral auditory apparatus.

The peripheral auditory apparatus.


Joseph Barrett's psychiatry.

Joseph Barrett's psychiatry.


Recent advances in veterinary and comparative ophthalmology.


Avian influenza viruses: in avian species and the natural history of influenza.


Pathogenesis of ruminant lactic acidosis.


Motility of the bovine and porcine uterus and fallopian tube.


Reticulosis of the central nervous system (CNS) in dogs.


The management of clinical and laboratory data in veterinary medine.


Wendell G. Scott, M.D. 1905-1972.

Wendell G. Scott, M.D. 1905-1972.


Geochemical and tectonic implications of South American metallogenic provinces.


Some contemporary issues in child development and the children of alcoholic parents.


The in vivo order of addition of ribosomal proteins in the course of E. coli 50s subunit biogenesis.


Modification of polyuridylic acid by bisulfite: effect on double helix formation and coding properties.


Peptidyl transferase: a new method for kinetic studies.


(Gly 2 )LRF and des-His  2 -LRF. The synthesis, purification, and characterization of two LRF analogues antagonistic to LRF.


Repair replication in different strains of Escherichia coli after treatment with alkylating agents and its dependence on protein synthesis.


Cell-free enzymic esterification of 5-carboxymethyluridine residues in bulk yeast transfer RNA.


Methylation of purified transfer RNA preparations by extracts derived from rat kidney and kidney tumours.


Biogenesis of  30 -S subunits during recovery from inhibition of protein synthesis.


Evidence for intra-chain masked carboxyl groups in polymeric collagen.


Immunoglobulins in disc electrophoresis.


Circadian rhythm of total urinary hydroxyproline excretion and 3-H hydroxyproline test.


Prophylaxis of experimental moniliasis in quail. A comparison of ethylenediamine dihydriodide, Benlate, sodium propionate, gentian violet, and nystatin.


Enhanced growth of Mycoplasma gallisepticum, strain 801.


Depronal SA: sustained-action dextropropoxyphene.


In memoriam Emil Froeschels.

In memoriam Emil Froeschels.


Histocompatibility mutations in mice: chemical induction and linkage with the H-2 locus.


Anomalously revertible r II  mutants of phage T 4 .


The integration of autonomous transmissible plasmids into the chromosome of Escherichia coli K12.


Clinical effects of proteolytic enzymes after reconstructive hand surgery. A double-blind evaluation of oral trypsin-chymotrypsin.


The Gorgas Hospital in World War II.

The Gorgas Hospital in World War II.


Clinical evaluation of the Makari tumor skin test in 470 patients.


Alterations in skin morphology in heloma durum utilizing maceration technique for examination of epidermal-dermal interface.


Cerebral O 2 , CO 2 , regional cerebral vascular control, and hyperbaric oxygenation.


Muscle metabolites and oxygen uptake in short-term submaximal exercise in man.


Modified technique for measuring pulmonary shunts using xenon and indocyanine green.


A method for preparing oxyntic cells from frog gastric mucosa.


A simple chemical method to differentiate Mycobacterium from Nocardia.


Effects of coumarin, pyronin Y, 6,9-dimethyl 2-methylthiopurine and caffeine on excision repair and recombination repair in Escherichia coli.


Physiological, chemical and ultrastructural characteristics of Corynebacterium rubrum.


Abortive transuction of motility in Proteus and Providence strains.


Pulmonary factors produced by septic shock: cause or consequence of shock lung?


Prostaglandins and therapeutic abortion. Clinical findings indicate that prostaglandins are potent oxytoics agents and that they may play a physiological role in labor and abortion.  A number of clinical trials have demonstrated the successful induction of abortion in the 1st and 2nd trimesters of pregnancy using intravenous PGF2 alpha.  A recent clinical trial by the authors using intravenous PGF2 alpha on 10 women 10-15 weeks pregnant resulted in 9 complete abortions and 1 incomplete abortion requiring surgical intervention.  Induction-abortion interval ranged from 7 hours 55 minutes to 31 hours 39 minutes with a mean of 24 hours 41 minutes.  Total amount of PGF2 alpha in the 9 successful cases had a mean value of 93.53 mg.  There were side effects in all patients but no serious complications.  A high incidence of side effects was observed at the 50 mcg/minute level; all regressed rapidly upon termination of infusion.  The study suggests that PGF2 alpha is an effective abortifacient in both the 1st and 2nd trimesters.  When compared with suction termination in the first trimester, prostaglandin use was more time consuming, more demanding of supervisory personnel, less successful, and thus more expensive.  Further research must be done to determine how prostaglandins work, their efficacy, and optimum methods of administration and safety.


In memoriam. Fred L. Adair 1878-1972.

In memoriam. Fred L. Adair 1878-1972.


Diagnosis of clinical endotoxemia.

Diagnosis of clinical endotoxemia.


Treatment for early syphilis and reactivity of serologic tests.


Clinical bone-marrow transplantation workshop.


Rosette-forming cells and plague-forming cells in primary immune response in vitro.


Automatic tissue processing with low viscosity nitrocellulose in tetrahydrofuran for large histological specimens.


Immunoglobulins on the surface of neoplastic lymphocytes.


Immunosuppressive therapy. 2.

Immunosuppressive therapy. 2.


Surgery for chronic suppurative otitis media.


Lymphocyte surface markers.

Lymphocyte surface markers.


A comparative trial of doxepin and diazepam in anxiety states.


A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant.


The heart and the rheumatic diseases.

The heart and the rheumatic diseases.


Thomas Hodgkin--the man and his times.

Thomas Hodgkin--the man and his times.


Ibuprofen in the management of osteoarthrosis of the hip.


Bacteriophage-directed association of DNA polymerase 1 with host membrane: a dispensable function.


Excision-deficient mutants of bacteriophage P2.


Isolation and a preliminary characterization of temperature-sensitive mutants of adenovirus 12.


Genetics of bacteriophage P22. I. Isolation of prophage deletions which affect immunity to superinfection.


The effect of lambda red genes on recombination of phage 186.


Genetics of bacteriophage P22. II. Gene order and gene function.


Induction of an endonuclease by some substitution and deletion variants of phage lambda.


The genetic map of the filamentous bacteriophage f1.


Secondary treatment of perforating injuries and surgical treatment of other injuries to the eye.


Discussion of surgical procedure in problem cases.


Surgical treatment of primary injuries to the eyeball.


Adrenal mineralocorticoids causing hypertension.


The treatment of hypertension. Why, when and how.


Planar relationships of semicircular canals in the cat.


Clinical comparison of terbutaline and isoprenaline administered by inhalation. A double-blind study.


Biological activities of the complement system.


Drugs and heart muscle.

Drugs and heart muscle.


Renal excretion of drugs: tubular transport and metabolism.


Science and fate. Oskar Eichler.

Science and fate. Oskar Eichler.


Transport and storage of biogenic amines.


The pharmacology of dimethyl sulfoxide.

The pharmacology of dimethyl sulfoxide.


Immunosuppressive agents.

Immunosuppressive agents.


The pharmacology of mercury compounds.

The pharmacology of mercury compounds.


Toxicity of airborne chemicals: air quality standards--a national and international view.


History and highlights of Finnish pharmacology.


Review of reviews.

Review of reviews.


The enigma of bullous pemphigoid and dermatitis herpetiformis.


Tissue culture of Kaposi's sarcoma.

Tissue culture of Kaposi's sarcoma.


Alimentary Candida albicans and napkin rashes.


Retinoic acid in the treatment of psoriasis.


Diuretic therapy.

Diuretic therapy.


A tribute to Muriel Driver.

A tribute to Muriel Driver.


Surgery in ischemic heart disease--angina pectoris and myocardial infarction.


Aggression, oedipus, and historical perspective.


Radioimmunoassay in gastroenterology.

Radioimmunoassay in gastroenterology.


Experience with the microhemagglutination test for Treponema pallidum antibodies.


John Wesley's dental therapeutics.

John Wesley's dental therapeutics.


Diagnosis and orthodontic treatment of a patient with hypothyroidism: report of case.


Over-the-counter denture reliners and repair kits. Council on Dental Materials and Devices.


Optimal conditions for the production and classification of sympathetic ganglion cultures from chick embryos.


Meshwork patterns in the ground substance of articular cartilage and nucleus pulposus.


A possible origin of pale neurosecretory granules in the neurohypophysis.


Urinary excretion of sodium and potassium in relation to plasma aldosterone concentration.


Evidence for indirect production of DNA strand scissions during mild heating of Escherichia coli.


Inhibition of the interaction between fimbrial haemagglutinins and erythrocytes by D-mannose and other carbohydrates.


Induction of phage formation in lysogenic Escherichia coli by myxin.


Effect of evaporation losses on experimental continuous culture results.


Calculation of interfacial stress in dental porcelain bonded to gold alloy substrate.


A theory of piezoelectric activity and ion-movements in the relation of flagellar structures and their movements to the phototaxis of Euglena.


Establishment of microorganisms isolated from chickens in the digestive tract of germ-free chickens.


Immune response against hamster erythrocytes in the low-responder mouse strains. I. Strain difference in the antibody response to primary antigenic stimulation and its disappearance after pre-sensitization with the antigen in Freund's complete adjuvant.


Biphasic changes in the avidity of antibodies at the cellular level during the immune response of mice to bovine erythrocytes.


Double infection, recombination, and segregation of two R factors R 100 and Rts1, and their possible bearing on the genetic structure of R 100.


Chekhov, the physician.

Chekhov, the physician.


A preliminary survey of the incidence and aetiology of spinal paralysis.


Urological problems in children with spina bifida cystica and sacral defects.


Vesico-ureteric reflux in paraplegia: results of various forms of management.


The relationship between "vasa sanguinea vasorum" and aortic degenerative changes in the domestic swine.


Morphine enhances lateral hypothalamic self-stimulation in the rat.


Diethylstilbestrol: observations on its use in Duchenne's muscular dystrophy (DMD).


Genetic influence of renal homografts on the blood pressure of rats from different strains.


A chick embryo model for the study of allograft rejection.


Effect of beta-adrenergic blockade on plasma volume in human subjects.


Deaf-mutes--studies by Alexander Graham Bell.


Ulcerative tracheo-oesophageal fistula during treatment by tracheostomy and intermittent positive pressure ventilation.


A case of immune complex glomerulonephritis in a dog.


The social environment: behaviour and stress in housed livestock.


Malignant oedema in antelopes.

Malignant oedema in antelopes.


Classic pages in obstetrics and gynecology by Henry H. Turner. A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology, vol. 23, pp. 566-574, 1938.


Current reference works in public health.


The fiftieth anniversary of the maternal and child health section: some remarks on its background and origin.


In memoriam. Dr. George James.

In memoriam. Dr. George James.