Organ donation: for whose sake?

Organ donation: for whose sake?


Transferable drug resistance among Escherichia coli isolated from human faeces and urine.


Exfoliative cytology of the biliary tract with the use of saline irrigation under choledochoscopic control.


A computer assisted derivation of a screening interview for hysteria.


Factors responsible for urinary fistula in the renal transplant recipient.


Premorbid asocial adjustment and response to phenothiazine treatment among schizophrenic inpatients.


The development of psychiatric concepts in traditional Chinese medicine.


In memoriam. Frank H. Krusen, M.D. 1898-1973.


Dudley Arthur Gill, F.R.C.V.S., D.V.S.M.


Leo William Mahaffey, B.V.Sc.

Leo William Mahaffey, B.V.Sc.


Stanley Allin Mountjoy, L.V.Sc.

Stanley Allin Mountjoy, L.V.Sc.


Isolation of a nuclear fraction from guinea pig polymorphonuclear leukocytes after controlled hypotonic homogenization.


Fertilization: a comparative ultrastructural review.


Bacterial osteomyelitis and synovitis of the turkey.


Transcellular ion flow in Escherichia coli B and electrical sizing of bacterias. Dielectric breakdown of cell membranes and, in response, transcellular ion flows were measured in Escherichia coli B 163 and B 525 using a Coulter counter as the detector with a hydrodynamic jet focusing close to the orifice of the counter. Plotting the relative pulse height for compensated amplification of a certain size of the cells against increasing detector current, a rather sharp bend within the linear function was found, which did not occur when measuring fixed cells or polystyrene latex. The start current for transcellular ion flow causing the change of the slope is different for the potassium-deficient mutant B 525 in comparison with the wild-type B 163, indicating a change in the membrane structure of B 525 by mutation and demonstrating the sensitivity of the method for studying slight changes in membrane structure in general. The theoretical size distributions for two current values in the range of transcellular ion flow were constructed from the true size distribution at low detector currents, assuming an idealized sharp changeover of the bacterial conductivity from zero to one-third of the electrolyte conductivity.


The aetiology of hypertension after renal transplantation in man.


Infectious bronchitis outbreaks in vaccinated poultry in Connecticut.


Prophylaxis in iliofemoral venous thrombosis. The major amputee as a clinical research model.


Replacement of ureter of a transplant kidney with an isolated segment of ileum: a case report.


"Closed" external sphincterotomy for bladder outlet obstruction in myelomeningocele.


Epidemic venereal disease due to Candida albicans in geese in Israel.


Effect of hyperbaric oxygen on experimental syphilis in the rabbit.


Case report--isolation from turkeys of biochemically variant pathogenic Escherichia coli.


Salmonella in Adélie penguins (Pygoscelis adeliae) and South Polar Skuas (Catharacta maccormicki) on Ross Island, Antarctica.


North Carolina turkey enteric virus: further characterization.


Treponema pallidum haemagglutination assay in the routine serodiagnosis of treponemal disease.


Long-term results of penicillin treatment of early and late forms of syphilis in the rabbit.


Gonorrhoea in the chimpanzee. Serological testing.


An outbreak of type-C botulism in broiler chicken.


Single and triple dose treatment of Trichomonas infection of the vagina.


Case report--salmonellosis in a robin.

Case report--salmonellosis in a robin.


Nuclear binding of tritiated actinomycin in basal cell carcinoma and in normal human epidermis.


Enhancement of normal lymphocyte cytotoxicity by sera with high antibody titers against H-2 or virus-associated antigens.


Ultrastructural studies on Regan and non-Regan isoenzymes of alkaline phosphatase in human ovarian cancer cells.


Tomizo Yoshida.

Tomizo Yoshida.


In vivo and in vitro evaluation of immune response of hamsters to immunization and transplants of autochthonous reticulum cell sarcoma.


Alkylation of transfer RNA by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.


Robert Merrill Boynton. Edgar D. Tillyer medalist for 1972.


Synthesis of antihemophilic factor antigen by cultured human endothelial cells. Antihemophilic factor (AHF, Factor VIII) antigen has been demonstrated in cultured human endothelial cells by immunofluorescence studies using monospecific rabbit antibody to human AHF. Control studies with cultured human smooth muscle cells and human fibroblasts were negative. By radioimmunoassay it was demonstrated that cultured human endothelial cells contain AHF antigen which is released into the culture medium. Cultured smooth muscle cells and fibroblasts did not have this property. Cultured endothelial cells incorporated radioactive amino acids into high molecular weight, AHF antigen-rich protein fractions prepared from the culture media, 7% of the radioactive amino acid counts incorporated into this material were precipitated by globulin prepared from rabbit anti-AHF whereas normal rabbit globulin precipitated only 1.5% of the counts. Although cultured endothelial cells actively synthesize AHF antigen, AHF procoagulant activity was not detected in the culture medium. Studies seeking a basis for the lack of procoagulant activity have not clarified this deficiency, but they have established that exogenous AHF procoagulant activity is not inactivated by the tissue culture system.


Effect of oral chenodeoxycholic acid on bile acid kinetics and biliary lipid composition in women with cholelithiasis. Bile acid kinetics and biliary lipid composition were characterized in six women with gallstones before and after 6 mo of oral therapy with chenodeoxycholic acid, an agent that induces dissolution of cholesterol gallstones in man. Over a dosage range of 1-4 g/day, absorption varied from 0.8 to 2.3 g/day. The chenodeoxycholic acid pool expanded two-to sixfold, and bile became composed predominantly (> 90%) of chenodeoxycholic acid conjugated chiefly with glycine. Cholic acid and deoxycholic acid pools decreased markedly, so that the total bile acid pool expanded much less, about twofold on the average. Cholic acid synthesis decreased in five of the six patients, consistent with negative feedback inhibition of cholic acid synthesis by chenodeoxycholic acid. In four patients whose bile was above or close to saturation with cholesterol, the bile became unsaturated; in two patients, whose bile was unsaturated, it remained so. In five patients with radiolucent gallstones, chenodeoxycholic acid therapy was continued after completion of kinetic and composition measurements; the stones decreased in size or dissolved entirely during the subsequent 6 to 18 mo. Similar measurements of bile acid kinetics and biliary lipid composition were made before and after a 6-mo period without medication in a control group of six healthy women; no changes occurred.


The rapid estimation of the area under the thermo-dilution curve.


Hemodynamics in essential hypertension.

Hemodynamics in essential hypertension.


Effect of chlorpromazine (CPZ) on insulin release in vivo and in vitro in the rat.


Obituary Isabella Ada Phillips.

Obituary Isabella Ada Phillips.


Letter: Malaria in the Australian army in South Vietnam.


Editorial: Paul Dudley White, 1886-1973.


Letter: Therapy for paroxysmal nocturnal hemoglobinuria.


Letter: Hypercalcemia after kidney transplant.


Letter: Treatment of idiopathic respiratory distress syndrome.


The island-flap in thumb reconstruction.


In memoriam: Harry Berelowitz.

In memoriam: Harry Berelowitz.


Alteration of certain pulmonary smoke exposure reactions by phenylmethyloxadiazole (PMO).


Electrophoretic variation in Escherichia coli from natural sources. At each of five loci in 829 Escherichia coli clones from 156 samples from diverse natural sources, electrophoretic analysis reveals a prominent mobility class (frequency over 0.70) and 2 to 11 distinct mobility classes at lower frequencies. The frequency distribution of the classes argues against the importance of neutral mutations in allozymic variation. Heterosis is not the universal cause of genic polymorphism.


Intravesical urinary salt precipitations on catgut and Dexon sutures. An experimental study.


Evaluation of a bacteriuria screening test in a large hospital environment.


Timely topics in general microbiology, 1970-1971.


Timely topics in microbiology, 1970-1971: miscellaneous bacteria, antibiotics.


Reliability of histopathologic diagnosis of malignant lymphoma.


Antinuclear antibodies. Comparison of the morphological aspects and sensitivity of immunoperoxidase and immunofluorescence techniques.


Pathogenesis of the blister in cicatricial pemphigoid and in bullous pemphigoid. A comparative ultrastructural study.


Evaluation of section thickness of skin in determining the epidermal labeling index with tritiated thymidine.


Observations for Icelanders on hydatids and precautions against them.


Luteinizing hormone-releasing hormone analogs lacking N-terminal pGlu ring structure.


Selective methylation of newly synthesized transfer RNA from an rel mutant of Escherichia coli during methionine starvation.


Phenylalanyl-tRNA synthetase from E. coli: synergistic coupling between the sites for binding of L-phenylalanine and ATP.


DNA replication in isolated HeLa cell nuclei.


Affinity labeling of E. coli RNA polymerase with substrate and template analogues.


Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets.


The deoxyribonucleic acid-modification enzyme of bacteriophage P1. Subunit structure. The bacteriophage P1 modification enzyme was purified 1400-fold from induced lysogens of a thermoinducible mutant of bacteriophage P1. The most purified fraction, when analysed by polyacrylamide-gel electrophoresis in sodium dodecyl sulphate, showed two principal stained bands. The two bands co-sedimented in a glycerol gradient with the modification activity, at a rate which, when compared with the rate of sedimentation of marker proteins, corresponds to a sedimentation coefficient in water of 6S. The mobilities of the bands on sodium dodecyl sulphate-polyacrylamide-gel electrophoresis corresponded to polypeptides of molecular weight 70000 and 45000 and they were present in equimolar amounts. It was concluded that the 6S species of the enzyme is a dimer of unlike subunits.


Studies on the high-sulphur proteins of reduced Merino wool. Amino acid sequence of protein SCMKB-3A3. The complete amino acid sequences of wool protein SCMKB-IIIA3 (131 residues) and a minor component SCMKB-IIIA3A (130 residues) have been determined. The proteins are mutually homologous and have free threonine as the N-terminal residue and carboxymethylcysteine as the C-terminus. The peptides used for the sequence work were obtained by trypsin, thermolysin, pepsin and chymotrypsin digestions and were fractionated by chromatography on DEAE-cellulose, gel filtration on Sephadex G-25 and G-50, paper chromatography and electrophoresis. The Edman degradation method (employing both the Beckman Sequencer and a non-automatic procedure) was used to obtain the sequences of the peptides.


The kinetics of hydrolysis of synthetic glucuronic esters and glucuronic ethers by bovine liver and Escherichia coli beta-glucuronidase. 1. The relative rates of hydrolysis of synthetically prepared beta-d-glucuronic esters [aglycone: benzoic acid, veratroic (3,4-dimethoxybenzoic) acid, indol-3-ylacetic acid and ethylbutyric acid], and beta-d-glucuronic ethers (aglycone: phenolphthalein, p-nitrophenol, 3,4-dimethoxyphenol, 3,4-dimethoxybenzyl alcohol) by commercial preparations of beta-glucuronidase from bovine liver and Escherichia coli were investigated. The rates of hydrolysis of all compounds tested were followed by measuring the formation of glucuronic acid under conditions which do not affect the glycosidic ester bond. 2. The pH profiles of the substrates in reaction with the enzyme from both sources were determined, and substrate-saturation curves at the optimal pH for each substrate were constructed; double-reciprocal plots of activity against concentration were linear. 3. Comparison of kinetic data indicates that neither the type of sugar-aglycone linkage, nor the aglycone structure alone can explain the observed K(m) and V(max.) values. 4. alpha-d-Glucuronic esters of benzoic and veratroic acid resisted hydrolysis by beta-glucuronidase from both sources.


Response threshold to levodopa in psychiatric patients.


Antinuclear factor in psychiatric patients.


Large scale production of bacteriophage phi x 174.


Arousal levels and attribution effects in diazepam-assisted flooding.


Controlled trial of dipotassium clorazepate ("Tranxene") in anxiety.


Nitrosoureas in central nervous system tumors.


An overview of the status of the nitrosoureas in other tumors.


Historical development and future promise of the nitrosoureas as anticancer agents.


Epidemiology of antibiotic and heavy-metal resistance in bacteria: a computer-based data system.


Enzymes and minerals in normal and mastitic milk.


Knee arthrography.

Knee arthrography.


The radiological evaluation of intraperitoneal gas (pneumoperitoneum).


The effects of dopamine on cardiogenic and endotoxin experimental shock. Studies on dogs show that dopamine improves cardiac performance and increases renal and mesenteric flow.  This paper investigates the cardiovascular effects of dopamine on narcotized dogs.  0.2 ml. of mercury was administered into the circumflex branch of the left coronary artery of 2 groups of anesthetized dogs to induce myocardial infarction.  1-3 mg/lg of Eschrichia coli endotoxin was injected in 2 other groups of dogs to induce endotoxin shock.  Dopamine was administered intravenousely in one group with cardiogenic shock and in the other group with endotoxin shock; noradrenaline was administered in the other 2 groups.  Coronary resistances increased after induction of shock and declined towards normal after dopamine was injected.  The effect of dopamine on mesenteric and renal resistance was not signficant.  Noradrenaline's effect on cardiac performance was similar to that of dopamine, although unlike dopamine, it contributed to a significant increase of total peripheral, coronary, mesenteric, renal and femoral resistances.  The effects of dopamine on the dog's hemodynamics were less evident in endotoxin than in cardiogenic shock on account of the fact that in endotoxin shock, circulatory blood volume declines to a higher extent than in cardiogenic shock, and greater blood alterations develop, mainly acidosis.  In such conditions, dopamine alone will not help the hemodynamic parameters return to normal levels.  Lotto et al. reports that in shocked humans with serious metabolic acidosis, dopamine is effective only when bicarbonate solutions are infused to adjust blood PH.


Blood flow in sympathetically denervated dog kidney.


Effect of partial dehydration of ex vivo canine stomach on secretory function.


Heterotopic allogeneic heart transplantation in dogs. Experimental investigations for early detection of the rejection after immunosuppressive monotherapy with ALS or azathioprine.


Pathogenesis of Marek's disease in old chickens: lesion regression as the basis for age-related resistance. Chickens of various age levels, free from prior infection, were simultaneously exposed to Marek's disease virus, and the response of each age group was recorded. Four- and 20-week-old chickens of lines 15x7 and CM (commercial source) had substantial resistance to mortality and gross lesions. In contrast, in line 7, which was tested at 1-day, 2-, 4-, 8-, 12- and 16-week age levels, 4-week-old chickens were fully susceptible to clinical Marek's disease (MD), although resistance was demonstrated at 8-week and older age levels. Genetically resistant chickens of line 6 maintained their resistance at all age levels tested. Pathogenesis of MD was compared in 12-week-old and 1-day-old chickens of line 15x7. Within the 1-day-old group, 23% of the chickens died because of MD, whereas there were no deaths in the 12-week-old group. Both groups developed viremia although duration, incidence, and levels of virus in the 1-day-old group were higher than in the 12-week-old group. Although initially the 12-week-old group responded by producing higher levels of antibody, the long term incidence of agar gel precipitin, immunofluorescent, and virus neutralization antibody in the two groups was similar. Gross and microscopic lesions of MD developed in both groups, but lesions regressed in the 12-week-old group and persisted in the 1-day-old group. It was concluded that age resistance to MD was expressed through lesion regression.


Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man. Enterotoxin preparations derived from Escherichia coli strain H-10407 were shown to contain vascular permeability factor (PF) activity as well as diarrheagenic activity. Intradermal injection of E. coli enterotoxin (ECT) caused localized induration and permeability of small blood vessels of the skin to intravenously administered Evans blue dye. The PF assay described here demonstrated a linear dose response and was at least as sensitive as the adult rabbit ileal loop assay for detecting ECT. E. coli PF activity was heat labile and was neutralized by homologous antiserum. PF production was enhanced by the addition of yeast extract (up to 0.6%) to a Casamino Acids-salts medium. PF activity was detectable as early as 6 h in aerated (shake) cultures in the Casamino Acids-yeast extract-salts medium, pH 8.5, maximal at 18 h and essentially unchanged at 48 h. The skin test (PF) assay for ECT has numerous advantages over current assay methods which involve gastrointestinal challenge of experimental animals.


Identification of enterotoxigenic Escherichia coli and serum antitoxin activity by the vascular permeability factor assay. Twenty-five strains of enterotoxigenic (tox(+)) Escherichia coli isolated in India, Bangladesh, and the U.S.A. were shown to produce vascular permeability factor (PF) activity as well as diarrheagenic activity. Sixteen strains of non-enterotoxigenic E. coli were found to be PF negative. The PF response elicited by tox(+)E. coli isolated in the U.S.A. from cases of infantile diarrhea was qualitatively different and more difficult to demonstrate. However, this problem was surmounted by assaying 25-fold concentrates of the crude enterotoxin of these strains. PF activity of various strains of tox(+)E. coli was neutralized by anti-PF antiserum prepared against the enterotoxin of strain H-10407. This anti-PF antiserum also neutralized PF activity of Vibrio cholerae enterotoxin (choleragen). Antiserum containing antibody specific for purified choleragen neutralized E. coli PF activity. These and other results indicate that the PF activity of E. coli is a function of the diarrheagenic enterotoxin as is known to be the case with choleragen. We conclude that the PF assay can be employed for the identification of tox(+)E. coli and for the detection of antitoxic antibody.


Virulence of six strains of Mycobacterium bovis (BCG) in mice. The abilities of six strains of Mycobacterium bovis strain BCG to replicate in vivo and to cause spleen enlargement in the CDF(1) male mouse were compared. The strains were grown in synthetic medium and harvested soon after complete pellicles were produced on liquid medium. In addition, two freeze-dried commercially available preparations were tested. The comparisons were made on the basis of injecting equal numbers of colony-forming units. Strain differences were marked. The Brazil strain was most effective in stimulating spleen enlargement, and the Japan strain was the least effective. This correlated with the number of colony-forming units isolated from the spleen.


Immunity to syphilis. I. Passive transfer in rabbits with hyperimmune serum. Passive transfer of humoral immunity to experimental syphilis in rabbits was accomplished with large doses of hyperimmune serum. When the serum was administered before inoculation of Treponema pallidum, the onset of chancres was delayed; when it was given early in the course of infection, a transient period of arrest and healing of the chancres was imposed.


Antibody-forming cells and serum hemolysin responses of pastel and sapphire mink inoculated with Aleutian disease virus. The effect of Aleutian disease virus (ADV) on serum hemolysin titers and antibody-forming cells in lymph nodes and spleens of sapphire and pastel mink inoculated with goat erythrocytes (G-RBC) was investigated. ADV injected 1 day after primary antigenic stimulation with G-RBC did not depress the immune responses of either color phase for a period of 26 days. However, when G-RBC were injected 47 days after ADV, both the number of antibody-forming cells and hemolysin titers were more markedly depressed in sapphire than in pastel mink. The results are discussed in relation to the greater susceptibility of sapphire mink and the variable susceptibility of pastel mink to the Pullman isolate of ADV.


Polyarthritis associated with Salmonella infection in rats. Rats infected intravenously with Salmonella enteritidis develop a chronic destructive polyarthritis. The joint lesions resemble those of human rheumatoid arthritis in distribution and pathology. On the basis of histological and microbiological studies, involvement does not appear to be the result of intra-articular sepsis. Instead, the data favor the view that transient infection incites an immunological response that localizes in the joint and becomes destructive.


An ultrastructural analysis of Nocardia during experimental infections in mice. Several strains of Nocardia that varied from virulent to avirulent were injected intraperitoneally into young mice. Histological and ultrastructural analysis of the resultant infections revealed that the bacteria and the lesions they induced were different depending upon the strain of organism used. Further, the morphological and tinctorial characteristics of the bacteria grown in vitro changes during growth in vivo. These observations strongly suggested that chemical and physical alterations occurred in the cell envelope of the Nocardia when grown in mice. Electron microscopy confirmed that significant structural modification occurred, especially in the cell envelope, when the nocardial cells established themselves within the host tissue. It was shown that the least virulent strain exhibited the most dramatic changes whereas the most virulent organism appeared to be affected the least.


Identification of bacteria by computer: general aspects and perspectives.


R factors from Proteus morganii.

R factors from Proteus morganii.


Myelin-specific autoantibodies associated with central nervous system demyelination in canine distemper virus infection. Sera from dogs with spontaneously occurring and experimentally produced canine distemper virus-associated demyelinating encephalitis were examined for antibodies to central nervous system myelin by the complement fixation and indirect immunofluorescent methods. Complement-fixing immunoglobulin M antibodies and non-complement-fixing immunoglobulin G antibodies were found in 97% of the spontaneous cases. In comparison, only 28% of control sera contained these antibodies; furthermore, mean antibody titers in the control groups were significantly lower (P < 0.005) when compared to the distemper group. Complement-fixing antimyelin antibodies were also demonstrated in gnotobiotic dogs with experimentally induced distemper virus-associated demyelination. The antibody response could be correlated with clinicopathological features of the disease produced. Results of this study indicate that demyelination in canine distemper may proceed by immune mechanisms.


Suppression of Candida albicans by human oral streptococci in gnotobiotic mice. Mixed human salivary bacteria and strains of Streptococcus salivarius and S. miteor suppressed colonization of Candida albicans in gnotobiotic mice. C. albicans attached in lower numbers to epithelial cells from conventional rats than from germ-free rats, and attachment inhibition by indigenous flora may explain in part the suppression of Candida colonization.


Identification of bacteria by computer: identification of reference strains.


Identification of bacteria by computer: theory and programming.


Osmotic lysis of sphaeroplasts from Saccharomyces cerevisiae grown anaerobically in media containing different unsaturated fatty acids.


Ultrastructural changes in the wall during germ-tube formation from blastospores of Candida albicans.


Some variables affecting the recovery of anaerobic bacteria: a quantitative study.


Plasmid-determined H2S character in Escherichia coli and its relation to plasmid-carried raffinose fermentation and tetracycline resistance characters. Examination of 32 H2S-positive strains isolated during the years 1950 to 1971.


Beta-galactosidase activity and lactose utilization in Aspergillus nidulans.


A correlation between oxygen requirements and the products of sterol synthesis in strains of Saccharomyces cerevisiae.


Hyperoxygenation: a central nervous system activator?


Thymine-requiring mutants of Proteus mirabilis selected by co-trimoxazole in vivo.


Responsibility for the care of the geriatric patient: legal, psychological, and ethical issues: the past, present, and future of a child's legal responsibility for support of his parents.


Use of L-phenylalanine mustard (Alkeran) in canine renal allografts.


Dihydroergotamine (Dihydergot) in the treatment of orthostatic circulatory disorders: a double-blind comparison with placebo.


Measuring social relationships in emotionally disturbed boys.


Rescue by chloramphenicol and rifampicin of UV-irradiated lon, exrA and recA mutants of Escherichia coli K12.


Mutagenicity of the carcinogen 7-bromomethylbenz (a)-anthracene: a quantitative study in repair-deficient strains of Escherichia coli.


A sensitive yeast assay system for carcinogenic nitroquinoline oxides.


Mammalian blood-mediated mutagenicity tests using a multipurpose strain of Escherichia coli K-12.


Chemotherapeutic sensitivity and viability of Nocardia asteroides and Nocardia brasiliensis in drugs.


Assessment of plane dipslide quantitation of bacteriuria.


The day of the dipslide.

The day of the dipslide.


Membranoproliferative hypocomplementemic glomerulonephritis.


Quartan malarial nephrotic syndrome.

Quartan malarial nephrotic syndrome.


The treatment of chronic renal failure in children by regular dialysis and by transplantation.


Psychological aspects of chronic renal failure and haemodialysis.


Kidney diseases in children. Forward.

Kidney diseases in children. Forward.


The early descriptions of the so-called tuning fork tests of Weber and Rinne. I. The "Weber test" and its first description by Schmalz.


Genetics of the Actinomycetales.

Genetics of the Actinomycetales.


Taxonomy and classification of the actinomycetes.


The Streptomyces spore: its distinct features and germinal behaviour.


General consideration and implications of the Actinomycetales.


Actinomycetes in soils, composts and fodders.


The occurrence and significance of actinomycetes in water supply.


Secondary metabolism with special reference to Actinomycetales.


Farmer's lung disease.

Farmer's lung disease.


Commensal and pathogenic Actinomyces species in man.


The significance of bifidobacteria in the intestinal tract of infants.


Proceedings: Techniques for the isolation and characterization of Actinomyces and Bifidobacterium species: report of a panel discussion.


Proceedings: Techniques for the isolation and identification of aerobic Actinomycetales: summary of the discussion session.


A sociomedical survey of doctor-patient contacts. Spot testing of the adult population of Roskilde, Denmark.


An immuno-electron microscopy of the soluble antigen of Trypanosoma gambiense.


The evaluation of quinine alone or in combination with tetracycline and pyrimethamine against falciparum malaria in Thailand.


Pathology of neonatal calf diarrhea induced by a coronavirus-like agent.


Triatomid bugs from Perlis.

Triatomid bugs from Perlis.


Canine nephrotoxic glomerulonephritis. A combined light, immunofluorescent, and ultrastructural study.


Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.


Causes of spinal compression in Egypt.

Causes of spinal compression in Egypt.


Longevity in radiated human populations, with particular reference to the atomic bomb survivors.


Experimental lung injury. I. Bacterial pneumonia: ultrastructural, autoradiographic and histochemical observations. Proteus infection in the rat produces an acute bacterial pneumonia which resolves without necrosis or significant organization within 2 weeks. Ultrastructural changes included widespread damage to type 2 cells and endothelial cells and rapid proliferation of the alveolar epithelial cells, which were the predominant site of labeling with tritiated thymidine. Histochemical staining for lysosomal enzymes showed an initial reduction in type 2 cell reactivity. The majority of proliferating epithelial cells were also unreactive until the normal pattern of staining and morphology returned at 8 to 12 days after infection. The acute inflammatory exudate was reactive, but there was only minimal to moderate staining in the subsequent clusters of alveolar macrophages. These data suggest that resolution with the preservation of the normal architecture of the peripheral airspaces may be correlated with superficial injury and limited reactivity for digestive enzymes.


Presentation of the Gold Headed Cane to John G. Kidd. February 24, 1973.


Hyperacute allergic encephalomyelitis. A localized form produced by passive transfer and pertussis vaccine. A hyperacute form of experimental allergic encephalomyelitis (EAE) has been produced previously by administering pertussis vaccine to rats actively immunized with neural antigen or given passive transfer of lymphoid cells from donors with EAE. Now, a localized form of hyperacute EAE has been produced within 1 day of passive transfer. The speed with which pertussis acts tends to exclude antibody production as the mechanism for conversion of EAE to the hyperacute form. With this rapid system, it has been found that pertussis, or its histamine-sensitizing factor, inhibited the host mononuclear cell component of the pervascular lesions. When the immune injury was sufficiently severe (high doses of donor EAE cells), the decrease in the number of mononuclear cells was accompanied by an increase in the amount of fibrin and the number of neutrophils in the lesions. This inverse relationship may be explained by the loss of the protective effect of mononuclear cells on vessels, a concept for which there is increasing evidence.


The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies. The stages in the development of the Mikulicz cell in human rhinoscleroma were studied in biopsy specimens obtained from 10 patients using light, immunofluorescent and electron microscopy. The Mikulicz cell was identified morphologically as a macrophage, not a plasma cell. Acutely inflamed areas of rhinoscleroma presented abundant bacteria with a slime layer. The microorganism was infrequent and the mucopolysaccharide was scanty in rhinoscleromal tissue, where plasma cells predominated, and in cicatricial fibrous tissue. In the granulomatous stage of rhinoscleroma, the mucopolysaccharide was found within the Mikulicz cells. The vacuoles observed in the Mikulicz cells were considered to be phagosomes containing, principally, bacterial mucopolysaccharide and few bacteria and, to a lesser extent, swollen mitochondria. It was concluded that the slime layer of Klebsiella rhinoscleromatis plays an important role in the pathogenesis of the disease. It is postulated that this material is a nondigestible mucopolysaccharide that resides in the phagosomes of macrophages, increases the osmotic pressure and forms multiple hydropic vacuoles that rupture not only the phagosomes but also the cells, resulting in the liberation of the mucopolysaccharide. This would initiate a cycle that would prolong the disease in the absence of the bacteria.


APA-approved doctoral programs in clinical, counseling, and school psychology: 1973.


APA-approved internships for doctoral training in clinical and counseling psychology: 1973.


Thrombogenesis of the rabbit arterial plaque. An electron microscopic study. Rabbit arteries, de-endothelialized with an intravascular balloon catheter and allowed to heal for 4 weeks, showed intimal changes that were similar to the preatherosclerotic fibromusculoelastic plaques of man. Reinjury of the healed vessels by balloon catheter produced marked quantitative and qualitative alterations of hemostasis, as compared to that in previously uninjured vessels. The most apparent modification of thrombogenesis 10 minutes after injury to the plaque was a large increase in the size of the thrombotic deposits. Features of this exaggerated response were the major participation of fibrin in thrombus formation and greater platelet accumulation. Some platelets and fibrin strands appeared to penetrate into and beneath the neointima. By 3 hours, these deposits had diminished in size, although the hemostatic mass remained larger in the doubly injured vessels.


Hereditary diseases in Finland; rare flora in rare soul.


Mechanisms of nonelectrolyte transport.

Mechanisms of nonelectrolyte transport.


A study of the thermal stability of ribosomes and biologically active subribosomal particles. 1. The ability of Escherichia coli ribosomes to function in poly(U)-directed protein synthesis was measured at elevated temperatures by using thermostable supernatant factors from Bacillus stearothermophilus. The amount of polyphenylalanine synthesized at 55 degrees C was about the same as at 37 degrees C, but the rate of synthesis was increased approximately fivefold. At 60 degrees C the activity of the ribosomes was halved. 2. E. coli ribosomes can sustain the loss of approx. 10% of the double-helical secondary structure of RNA without losing activity. 3. Within the active ribosome the double-helical secondary structure of the rRNA moiety is stabilized compared with isolated rRNA, as judged by enzymic hydrolysis and by measurements of E(260). 4. The main products, over the range 0-55 degrees C, of ribonuclease T(1) digestion of the smaller subribosomal particle of E. coli were two fragments (s(0) (20,w) 15S and 25.3S) of approximately one-quarter and three-quarters of the size of the intact molecule, revealing the presence of a ;weak spot' where intramolecular bonds appear insufficient to hold the fragments together. 5. Subribosomal particles of B. stearothermophilus were more stable to heating, by approx. 10 degrees C, than those of E. coli, and the stabilization of double-helical secondary structure of the RNA moiety was more striking. 6. Rabbit reticulocyte ribosomes were active in poly(U)-directed protein synthesis at 45 degrees C, and half the activity was lost after heating to 53 degrees C. Active subribosomal particles of rabbit reticulocytes and of oocytes of Xenopus laevis, like the bacterial subribosomal particles, underwent a conformational change to a slower-sedimenting form on heating. The temperature range of the transition depended on the species. 7. Slower-sedimenting particles, whether produced by EDTA treatment or by heating, had different ;melting' profiles compared with active subribosomal particles, providing another indication of conformational differences. 8. Comparison of the properties of the various subribosomal particles revealed greater variation in the secondary structure of the protein moieties (judged by measurement of circular dichroism) than in the secondary structure of the RNA moieties, which appeared to have features in common.


Scleroderma, pleural calcification and reticulum cell sarcoma of the lungs.


Allogeneic transplantation of organ cultures of adult human skin.


Anti DNA antibody production by lymphoid cells of NZB-W mice and human systemic lupus erythematosus (SLE).


Induction of ovulation with clompiphene citrate.


Mebutamate as a hypnotic: clinical trial and statistical considerations.


Studies on the metabolism in man of oxisuran, a differential immunosuppressive drug.


Clinical biostatistics. XXIV. The role of randomization in sampling, testing, allocation, and credulous idolatry (conclusion).


Expulsion of Nippostrongylus brasiliensis from the intestine of rats: evidence for a third component in the rejection mechanism.


Letter: Additivity of type O and type N damage in diploid yeast.


Serum corticosteroid-binding globulin, cortisol, and nonprotein-bound cortisol levels in patients receiving estrogen for carcinoma of the prostate.


Methadone-naloxone in combination for the treatment of heroin addicts.


Prevention of infected urinary stones by urease inhibition.


Bioavailability of digoxin tablets.

Bioavailability of digoxin tablets.


Sir Henry Thompson (1820-1904).

Sir Henry Thompson (1820-1904).


Impairment of performance with low doses of marihuana.


Hydralazine elimination in man.

Hydralazine elimination in man.


Obituary. Dr. Eugene Minkowski.

Obituary. Dr. Eugene Minkowski.


Kinetics of warfarin absorption in man.

Kinetics of warfarin absorption in man.


Amoxicillin therapy of infections.

Amoxicillin therapy of infections.


Fluoride: research on clinical and public health applications.


Cleft lip and palate: therapy and prevention.


Bone resorption in tissue culture and its relevance to periodontal disease.


Effects of mode of management on plasma chlorpromazine in psychiatric patients.


Dentistry: retrospect and prospect.

Dentistry: retrospect and prospect.


Oxprenolol: long-term effects in arterial hypertension.


Comparison of thioridazine and diazepam in the control of nonpsychotic symptoms associated with senility: double-blind study.


Long-term cholesterol-lowering effect of colestipol resin in humans.


Effect of synthetic luteinizing hormone-releasing factor on serum testosterone and gonadotropins in prepubertal, pubertal and adult males.


Hormonal responses to intranasal luteinizing hormone releasing hormone.


Nasal immunoglobulin responses in acute rubella determined by the immunofluorescent technique. The indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in nasal secretions from ten adults with acute rubella. Titres of IgA antibody in nasal washings usually exceeded those of IgG, but both types of antibody were detected in all patients. They appeared a few days after the rash, reached maximum titres during the second week and then declined. IgA antibody was no longer detectable after 47 days and was not detected at all in nasal washings from adults who had experienced rubella in the past. Low titres of IgG antibody persisted in some patients for longer than IgA and traces of IgG were found in nasal washings from a minority of adults with a past history of rubella. Nasal antibodies in acute rubella are therefore transient and unlikely to take part in resistance to reinfection.In sucrose-density gradients nasal IgA antibody sedimented more rapidly than IgG and there was little overlap between these two types of antibody. IgA antibody in serum was more heterogeneous; it was found in nearly all the fractions which contained IgG antibody and in many of those which contained IgM.


Bacteriophage restriction in Salmonella typhimurium by R factors and transfer factors. A total of 2716 R factors and transfer factors isolated from Escherichia coli and salmonellas of human and animal origin were studied for their phage-restrictive effects in Salmonella typhimurium phage type 36. All of 1402 wild fi(+) factors were non-restricting. The F factor of E. coli K12 was unique among the F-like factors tested in that it inhibited lysis of type 36 by one typing phage. In contrast, eleven distinct changes in the phage type of 36 were produced by fi(-) I-like factors. I-like plasmids can thus be subdivided by this method.I-like R factors and transfer factors from human and animal enterobacteria were categorized by their phage-restrictive effects in type 36. Factors resembling Delta in this respect predominated among fi(-) I-like factor from human E. coli and S. typhimurium and from porcine E. coli. Delta-like and ColI-like fi(-) factors were equally distributed in bovine S. typhimurium. ColI-like factors were commonest in bovine and avian E. coli.


Isolation and characterization of antigens reactive with pemphigus antibodies.


Further side-chain modification of antimalarial phenanthrene amino alcohols.


Spironolactone and plasma cortisol.

Spironolactone and plasma cortisol.


Further studies on the structure-activity relationships in the C-terminal part of luteinizing hormone-releasing hormone.


Effect of simple amino acid replacements on the biological activity of luteinizing hormone-releasing hormone.


Aharon Katzir-Katchalsky 1914-1972.

Aharon Katzir-Katchalsky 1914-1972.


Metabolism of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in rats.


Skin grafting of exposed arterial vein grafts: a clinical and experimental study.


Emergency care in Northeastern New York hospitals: report of a survey.


Effect of the daily injection of tolbutamide into pregnant rats on the pancreatic insulin content of their offspring.


Reversed pulsus paradoxus.

Reversed pulsus paradoxus.


Vulnerability of children to lead exposure and toxicity (second of two parts).


Otto J. Hermann, M.D., 1884-1973.

Otto J. Hermann, M.D., 1884-1973.


Sub-lethal effect of sulphaquinoxaline on the tsetse fly, Glossina austeni Newst.


Role of calcium in the seasonal modulation of pacemaker activity in a molluscan neurosecretory cell.


Letter: Smoking, pregnancy and publicity.


Amniotic fluid volume studies.

Amniotic fluid volume studies.


Malaria associated with pregnancy.

Malaria associated with pregnancy.


Editorial: Era of progress.

Editorial: Era of progress.


Molecular characteristics of biogenic monoamines and their analogs.


Beam characterization and monitoring of a high intensity pulsed electron source.


Integrated gas chromatography-mass spectrometry.


Association for Research in Nervous and Mental Disease.


Increased susceptibility of Cryptococcus neoformans to amphotericin B in the presence of steroids.


Indirect haemagglutination in pulmonary aspergilloma diagnosis.


The commensalism of Cryptococcus neoformans.


Mode of action of clotrimazole.

Mode of action of clotrimazole.


Mycetomas caused by Curvularia lunata, Madurella grisea, Aspergillus nidulans, and Nocardia brasiliensis in Sudan.


Phagocytosis of Candida albicans by rabbit neutrophils.


The ecology of Torulopsis in man.

The ecology of Torulopsis in man.


Obituary (Maxwell Littman).

Obituary (Maxwell Littman).


Osteoarthritis of the knee treated with tolfenamic acid.


The early operative management of injuries to great vessels.


Preparation and properties of poly 2-aminopurine ribotidylic acid.


Paul Lussheimer, M.D. 1898-1973.

Paul Lussheimer, M.D. 1898-1973.


The domain of hypnosis. With some comments on alternative paradigms.


Metal complexes of octaethylporphin: preparation, axial ligand substitution and reduction.


To those who weighed anchor before us and sailed uncharted seas.


Geochemistry of porphyrins-reactions during diagenesis.


Laboratory evaluation of normal donors undergoing leukapheresis on the continuous flow centrifuge.


Hans Fischer (1881-1945).

Hans Fischer (1881-1945).


Bacteriological study of platelet concentrates stored at 22C and 4C.


Proceedings: Study of duodenal microflora and bile acids and salts in contaminated small bowel syndrome.


A mathematical model for the measurement of individual influence in groups.


Wiskott-Aldrich syndrome associated with idiopathic infantile cortical hyperostosis (Caffey's disease).


A Medicare peer review committee for speech pathologists.


Proceedings: 5-year controlled trial of chelating agents in treatment of thalassaemia major.


2 DDG stimulation of gastric acid and pepsin secretion in dogs.


Basic and clinical study of intrathecal administration of lincomycin. Therapeutic experience with 15 cases of meningitis.


Cytology in gastroenterological diagnosis.


The determination, by four methods, of the availability and utilization of calcium and phosphorus in rats given diets containing different amounts of the elements.


Dracula and surgically induced trauma in children.


Rapid microbiological assay for 5-fluorocytosine. A microbiological assay was developed for 5-fluorocytosine based on inhibition by the drug of the fall in pH produced by Candida albicans in a synthetic liquid culture medium. Serum and urine levels of the drug could be measured reproducibly in four hours.


Letter: Spontaneous abortion and neural tube defects.


Recovery from profound hypothermia with cardiac arrest after immersion.


Smoking--now and then.

Smoking--now and then.


Surgical treatment of chronic osteomyelitis complicating fractures. A study of 50 patients.


Septic arthritis of childhood.

Septic arthritis of childhood.


The radiology of infection.

The radiology of infection.


Wound infection with Harrington instrumentation and spine fusion for scoliosis.


Pyogenic vertebral osteomyelitis. Disk space infections.


Erasmus' medical milieu.

Erasmus' medical milieu.


The making of an eclectic physician: Joseph M. McElhinney and the Eclectic Medical Institute of Cincinnati.


The prevention of infection in open wounds.


Musculoskeletal infections due to Serratia marcescens.


The treatment of chronic osteomyelitis by saucerization and immediate skin grafting.


Use of fascia lata in gynecologic surgery.


American doctors and the Parisian medical world, 1830-1840.


The effect of temperature on asanguineous rabbits.


Mechanisms of chromosome synapsis at meiotic prophase.


Comparative ultrastructure of the cerebrospinal fluid-contacting neurons.


The uses and abuses of opiates in nineteenth-century England.


The structure of mammalian chromosomes.

The structure of mammalian chromosomes.


Toxic oxygen effects.

Toxic oxygen effects.


Tests for differentiating Vibrio parahaemolyticus.


Isaac Arthur Abt, 1867-1955.

Isaac Arthur Abt, 1867-1955.


Respiratory failure in chronic airways obstruction.


Composite autogenous marrow and surface-decalcified implants in mandibular defects.


Osteomyelitis following fixation of a mandibular fracture with biphasic pins.


Treatment of a continuity defect of the mandible.


Recent advances in pediatric respiratory disease.


Treatment of chronic bronchial asthma in the adult.


The nasal mucus in leprosy.

The nasal mucus in leprosy.


An improved method of agar pelleted cells for electron microscopy.


Isolation of mycoplasmas from porcine lungs.


Hypoxaemia in acute myocardial infarction. A discussion of its significance, causes and treatment based on data from the literature.


Diffuse intravascular coagulation (DIC): a basic mechanism of disease in internal medicine. A survey of recent developments.


Abraham Lincoln's loss-complex.

Abraham Lincoln's loss-complex.


Psychoanalysis, the medical school and the university. (A tribute to M. Royden C. Astley, M.D.).


The question of the subject: Lacan and psychoanalysis.


A civilization without discontent: Marcuse vs. Freud.


Text of address delivered to American Health Congress, McCormick Place, Chicago, August 21, 1973.


Fatty acid composition of spore lipids of a proteolytic strain of Clostridium botulinum, type A.


Carbamyltaurine: absence of a role in taurine metabolism.


The Institute of Medicine of Chicago. Roster.


In memoriam. Percival Bailey, 1892-1973.


Antifertility agents: introduction and history. The article is a brief historical account of the birth and development of steroidal contraception.  Over 400 oral contraceptive agents have been and/or are in use.  Attention is called to particular medical writers who have composed excellent historical accounts of the development of the synthetic estrogens and progestins used in commercial and investigative oral contraceptives.


Clinical and epidemiologic aspects of oral contraceptive safety.


The use of clomiphene citrate in the treatment of anovulation.


In memoriam: James E. Landis. 1900-1973.


In memoriam: Daniel S. DeStio. 1906-1973.


Presidential address: Face to face with physiology.


A review of the early history of ophthalmic plastic surgery.


Clinical aspects of drug actions & interactions in veterinary practice.


Nutrition and infection.

Nutrition and infection.


Overnutrition.

Overnutrition.


Nutrition and oral problems.

Nutrition and oral problems.


Food additives.

Food additives.


Reviews relating to food, nutrition and health. A selected bibliography.


Nutrition and aging in technically underdeveloped societies.


Detection and quantitation of bacteria in platelet products stored at ambient temperature.


Improved granulocyte procurement with the continuous flow centrifuge.


Physicochemical investigations on DNA isolated from bacteria after photodynamic inactivation.


Simultaneous transfer of gentamicin and kanamycin resistance from a urine strain of Escherichia coli.


Paramyxovirus like tubules in multiple sclerosis biopsy material.


Acrodermatitis enteropathica and failure to thrive.


Pemphigus erythematosus provoked by allergic contact dermatitis. Occurrence many years after thymoma removal.


Stephan Epstein, MD 1900-1973.

Stephan Epstein, MD 1900-1973.


Idiopathic membranous glomerulonephritis occurring with diabetes mellitus.


Alcoholism. An important but unemphasized factor predisposing to infective endocarditis.


Candida endophthalmitis. A complication of candidemia.


Spontaneous perforation of the colon in chronic renal failure.


Leptospirosis in albino rats.

Leptospirosis in albino rats.


Isolation of a pathogenic strain of Acanthamoeba castellani in Romania.


Intermittent rifampicin treatment in experimental tuberculosis.


The politics of hearing: MEDICAID in New York City and the audiologist.


Bibliotherapy for the communication disordered: rationale and materials.


Biological function of 2-thiouridine in Escherichia coli glutamic acid transfer ribonucleic acid.


Transcription of chromatin. Initial and terminal nucleotides of ribonucleic acid synthesized by calf thymus and Escherichia coli ribonucleic acid polymerases.


Rose Bengal: a spectroscopic probe for ribonucleic acid polymerase.


Rose Bengal: an inhibitor of ribonucleic acid chain elongation.


Mitochondrial deoxyribonucleic acid synthesis in a temperature-sensitive mutant of deoxyribonucleic acid replication of Saccharomyces cerevisiae.


Ribonucleoside phosphates via phosphorimidazolidate intermediates. Synthesis of pseudoadenosine 5'-triphosphate.


Rubradirin, a selective inhibitor of initiation factor dependent peptide-chain initiation.


In vivo thermal stability and activation of Escherichia coli ribosomes.


Relationships between exploratory behaviour and fear: a review.


Early stimulation of rodents: a critical review of present interpretations.


Excision properties of DNA polymerase.

Excision properties of DNA polymerase.


Biosynthesis of vitamin B6. Incorporation of terminally labelled glucose.


Early clinical descriptions of skin cancer.


The enzyme-inhibitory properties of 1-alpha- and 1-beta-D-glucopyranosylimidazoles.


The age of menarche in Medieval Europe.

The age of menarche in Medieval Europe.


The significance of disease in the extinction of the New England Indians.


An analysis of the adequacy of medicaid prescriptions.


Imidazolylacetolphosphate aminotransferase. Properties of the apoprotein produced in a pyridoxine auxotroph of Salmonella typhimurium.


Persistence of deoxyribonucleic acid polymerase I and its 5'--3' exonuclease activity in PolA mutants of Escherichia coli K12.


Regulatory gene control of transcription of the L-arabinose operon in Escherichia coli.


A role for ribonuclease 3 in processing of ribosomal ribonucleic acid and messenger ribonucleic acid precursors in Escherichia coli.


The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. VII. Characterization of heterogeneous "core" oligosaccharide structures.


Bone magnesium pools in uremia.

Bone magnesium pools in uremia. Bone magnesium pools were studied in vitro in bone specimens obtained from control subjects, from patients with chronic renal failure before and after renal transplantation, and in a patient with chronic hypomagnesemia. 30% of bone magnesium is in a surface limited pool present either within the hydration shell or else on the crystal surface. The larger fraction of bone magnesium was shown not to be associated with bone matrix but rather to be an integral part of the bone crystal. With incineration this pool was mobilized at the same temperature that sudden enlargement of bone crystal size occurred. It is suggested that heating causes surface calcium to displace magnesium from the apatite crystal. Both magnesium pools are increased in patients with chronic renal failure. The major factor determining magnesium concentration in bone would appear to be the serum magnesium level. Following renal transplantation, in association with the fall in serum magnesium, surface magnesium was within the normal range; whereas, residual magnesium was not different from the other urenic bones. Both magnesium pools were significantly reduced in a patient with chronic hypomagnesemia. The in vitro studies would suggest that surface magnesium should rapidly reflect changes in serum magnesium levels, whereas, the deeper magnesium pool is probably deposited at time of bone formation with mobilization being dependent upon the resorptive processes. Since magnesium can influence crystal size and stability it seems possible that excess bone magnesium may play a role in renal osteodystrophy.


Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus. Peripheral blood lymphocytes from 23 patients with active systemic lupus erythematosus (SLE) were serially studied. Changes in bone marrow-derived lymphocytes (B cells), as measured by surface Ig receptors and C3 receptors, and in thymus-derived cells (T cells) measured by rabbit T-cell-specific antiserum and E-binding techniques, were correlated with fluctuations in clinical disease activity and treatment. In normal controls B- and T-cell percentages remained relatively stable, although the situation in SLE was much more labile. A relative and absolute decrease in T lymphocytes and cells bearing a receptor for C3 was found in active lupus. Absolute numbers of cells bearing surface Ig were decreased to a lesser extent, whereas the proportion of these cells was increased. It is postulated that the increase in autoantibody formation and diminished delayed hypersensitivity seen in systemic lupus may be due to a loss of T-lymphocyte function.


Human antiserum for prevention of the local shwartzman reaction and death from bacterial lipopolysaccharides. Bacterial lipopolysaccharides from dead bacteria have been blamed for the continuing high mortality from gram-negative infections despite antibiotic treatment. Because animal antiserum against these lipopolysaccharides has been shown to protect against several of the effects of endotoxin, we undertook the development of antiserum in human subjects. 21 men were immunized with a single injection of Salmonclla typhimurium or Escherichia coli 0:111 heat-killed cells and immune serum was collected at 2 wk. Preimmune serum was obtained as a control in all animal experiments. 1 ml antiserum given intravenously protected mice against a lethal intravenous dose of homologous endotoxin (P < 0.005 for both antisera). E. coli antiserum reduced the incidence of positive local Shwartzman reactions with E. coli endotoxin from 100 to 38%; S. typhimurium antiserum reduced the incidence from 92 to 35%. (P < 0.0005 for both antisera). There was no protection against heterologous endotoxin in either animal model. These experiments demonstrate for the first time that human antiserum confers exceedingly potent passive immunity to the effects of endotoxin.


Capillary-action replicator.

Capillary-action replicator.


An outbreak of infantile gastroenteritis due to E. coli 0142. Twelve cases of gastroenteritis caused by Escherichia coli 0142K86H6 are described. Ten of these cases were clearly involved in an outbreak of cross infection. The other two cases yielded interesting information on infection with E. coli. 0142. Five cases, two being fatal, required repeated intravenous infusion, and one further infant required parenteral replacement therapy on a single occasion only. Cross infection occurred at the primary site-a ward partitioned into cubicles-despite full barrier nursing techniques. Infection spread also to two other wards, and resulted from transfer of latently infected cases. Illness in several infants was protracted and debilitating because of the relapsing nature of the infection. The pathology of the two fatalities is reported briefly.


Incidence and isolation of Bacteroides species from clinical material and their sensitivity to antibiotics. One thousand and sixty-seven strains of anaerobic Gram-negative bacilli were isolated from routine clinical material between January 1971 and December 1972. Most of the strains were isolated from sites allied to the lower intestine and genito-urinary tract. Resistance to tetracycline was present in 39.2% of strains tested. In contrast only one strain was found resistant to clindamycin. It is suggested that the recovery of anaerobes from material sent to the laboratory depends largely on the efficiency of the anaerobic system used.


Membership roster of The Boston Society for Gerontologic Psychiatry, Inc.


Letter to the editor: Immunofluorescent techniques for the diagnosis of respiratory syncytial virus.


Medical education and medical care. Problems at the interface: National considerations.


Professional Standards Review Organizations. A critique.


Letter: Another counter-blaste.

Letter: Another counter-blaste.


Editorial: Preservation of kidneys for transplantation.


Letter: Malaria in the Australian army in South Vietnam.


Clinical experience with clonazepam (Rivotril) in the treatment of epilepsies in infancy and childhood.


Neurovascular regulation of the anterior hypophysis.


Microtubules and beta cell secretion.

Microtubules and beta cell secretion.


Studies on sex differentiation in mammals.


The chemistry of growth hormone and the lactogenic hormones.


The role of microtubles and microfilaments in thyroid secretion.


Luteinizing hormone-releasing factor potentiates lordosis behavior in hypophysectomized ovariectomized female rats. Subcutaneous injection of luteinizing hormone-releasing factor (LRF) in estrogen-primed hypophysectomized, ovariectomized female rats facilitates the appearance of the lordosis response. The LRF effect on lordosis was seen 90, 180, and 360 minutes after injection. This effect could help to synchronize the female's mating behavior with the ovulatory discharge of luteinizing hormone.


Evaluation of a functional index in rheumatoid arthritis.


Some applications of mass spectrometry in drug metabolism studies.


Comparative studies on the intestinal loop-dilating effect of live culture of Escherichia coli 0141: K85, 88 and its enterotoxin in miniature and large white pigs.


Disseminated intravascular coagulation.

Disseminated intravascular coagulation.


Albert Damon 1918-1973.

Albert Damon 1918-1973.


Interactive use of computer models in teaching population genetics.


A smiple specific assay for uracil tRNA methylases of enteric bacteria: use of ribothymidine-deficient tRNA.


Quantitative determination of aliphatic diamines and polyamines by an automated liquid chromatography procedure.


Computer preprocessing of ballistocardiograms.


An easily constructed elution chamber for preparative gel electrophoresis.


Nuclease contaminant of a batch of lysozyme used for ribosome extraction: cleavage of Escherichia coli 23S rRNA into two specific fragments.


Automatic computer processing of ultralow frequency ballistocardiograms.


A new dihydrolipoamide transacetylase in Escherichia coli K12.


Use of exhaustive nucleic acid hybridization for determining the amount and size distribution of newly synthesized bacterial message RNA.


Affinity chromatography by enzyme-substrate interaction. Purification of some rat liver glycosidases.


Studies on aspartase. I. Purification and molecular properties of aspartase from Escherichia coli.


Extracellular beta-glucanases of the yeast, Saccharomyces cerevisiae.


Effect of duodenal acidification on the gastric secretory response to pentagastrin in man.


Atomic absorption spectrometry of trace metals in clinical pathology.


Aspergillosis of the skin. Report of a case.


Using parents as change agents for their children: a review.


Histoincompatibility recognition reaction by irradiated or mitomycin-treated parental cells against hybrid spleen cells produces hybrid cell proliferation and illusion of reaction of hybrid against parent.


Binding of Maclura pomifera lectin to rat lymphoid cells and erythrocytes.


Leukemia virus-induced immunosuppression. IX. Depression of delayed hypersensitivity and MIF production after infection of mice with Friend leukemia virus.


Systemic immunity after local antigenic stimulation of the lymphoid tissue of the gastrointestinal tract.


Cystitis emphysematosa. A report of two cases.


Association of myasthenia gravis with pemphigus vulgaris, Candida albicans infection, polymyositis and myocarditis.


Applying the technics of cost-effectiveness to the delivery of dental services.


The conservative management of urinary fistulas following renal allografts.


A new spiral-flap urethroplasty.

A new spiral-flap urethroplasty.


Antacids vs placebos in peptic ulcer therapy. A controlled double-blind investigation.


ACS-NIH organ transplant registry. Third scientific report.


Seishu Hanaoka--his anesthesiology and surgery.


The 11th report of the human renal transplant registry.


Editorial: How many transplant centers do we need?


Editorial: Organ transplantation.

Editorial: Organ transplantation.


Predictive oncology. 3.

Predictive oncology. 3.


Carl Zeiss.

Carl Zeiss.


Letter: Double-blind studies in dermatology.


Editorial: Unaccustomed as I am to.

Editorial: Unaccustomed as I am to.


Effect of L-asparaginase on retention of maze learning in mice.


Neural control of motivated behavior.

Neural control of motivated behavior.


Baddeck--45 years of medicine. Dr. C. "Monty" MacMillan.


The dosage effect of enteric-coated ASA on serum salicylate levels.


Vitamin E: who needs it? I. The premature infant and E deficiency.


Methods of bracing in the rehabilitation of the paraplegic child.


Inhibition of Escherichia coli on cellulose acetate membrane filters.


Some experiences with non-traumatic paraplegia in Malaysia.


Obituary. Dr. Donald Munro.

Obituary. Dr. Donald Munro.


Susceptibilities of intracellular and surface sulphydryl groups of Escherichia coli to oxidation by hyperoxia.


Acute virus hepatitis.

Acute virus hepatitis.


A correlation between the antibacterial activity of some p-hydroxybenzoate esters and their cellular uptake.


Pipe and cigar smoking. The report of an expert group appointed by action on smoking and health.


Natamycin in the treatment of vaginal candidiasis in pregnancy.


Chorionic gonadotrophin in male growth-retarded adolescent asthmatic patients.


The value and limitations of psychosurgery in the treatment of psychiatric illness.


Physiology of bile acids in the ileum and colon.


Semiconductor detector systems.

Semiconductor detector systems.


Liquid scintillation counting in nuclear medicine.


Therapeutic outcome in limbic leucotomy in psychiatric patients.


Clinical and serological studies in Mexico with live attenuated mumps virus vaccine. (Jerry Lynn strain).


Vaccination with combined live measles and rubella vaccines.


Intracerebral interventions in patients with behavioural disorders.


Hemorrhagic disease of the newborn and vitamin K prophylaxis.


Unusual filling defect in the small bowel.


Some medical aspects of breast cancer.

Some medical aspects of breast cancer.


Report of the joint committee for stroke facilities. IX. Strokes in children. 1. Diagnosis and medical treatment of strokes in children.


Effect on patency of the length of thrombendarteriectomy.


Methods of assessing patients for psychosurgery and their outcome after operation.


Effect of histamine loading on the metabolism of 14C-histamine, administered intravenously or orally, in domestic animals (goat and pig).


Manufacturers of hospital pharmacy equipment and supplies.


Two forms of pyruvate kinase in E. coli: their properties and regulation.


Computer assisted optometry--a tutorial with examples.


Comparison of group IIf with Flavobacterium and Moraxella.


The reaction of the oral tissues to implants.


A common receptor protein for phage T5 and colicin M in the outer membrane of Escherichia coli B.


Lower oesophageal sphincter and peptic oesophagitis.


Zinc poisonings (a review).

Zinc poisonings (a review).


Discriminative interest of the study of basal acid secretion and pepsin acid correlation in Zollinger-Ellison syndrome and peptic ulcer.


The uricosuric action of halofenate (MK-185) in patients with hyperuricemia or uncomplicated primary gout and hyperlipidemia.


Phase II study of cis-diamminedichloroplatinum (NSC-119875) in advanced carcinoma of the large bowel.


Intermediate hemichrome formation after oxidation of three unstable hemoglobins (Freiburg, Riverdale-Bronx and Köln).


Evidence for multiple cistrons for haemoglobin messenger RNA.


A salute to the Association' Presidents.


Synthesis of rabbit globin in a cell free system.


High-dose intermittent intravenous infusion of procarbazine (NSC-77213).


Plastic embedding and surface erosion techniques in soft tissue scanning electron microscopy.


Stabilization of a free floating premaxilla by ridge bars: report of case.


Scanning electron microscopy of etched Epon extraocular muscle sections.


Nutrient utilization by peritoneal exudate cells.


Equivalence of limiting dilution analysis and the hemolytic focus assay. Test of a prediction based on a model of cellular interaction between T and B cells.


Migration inhibitory factor induction by nonspecific mitogenic stimulation of mouse lymphocytes.


Fundamental theoretical aspects of bacterial chemotaxis.


Growth of measles virus in nervous tissues. 1. Neurotropic properties of measles virus in newborn hamsters.


A review of mycetomas in Turkey.

A review of mycetomas in Turkey.


Experimental maduromycosis. I. Infection of mice with Phialophora jeanselmei.


Pathogenicity of the Y form as compared to M form in experimentally induced Candida albicans infections.


Growth stimulation and inhibition of Candida albicans by metabolic by-products.


A morphologic mutation in Aspergillus nidulans associated with increased virulence for mice.


Effect of tetracycline on the virulence of Y and M forms of Candida albicans in experimentally induced infections.


Asymptomatic bacteriuria and the nephrotic syndrome in children.


Dental ingenuity through the ages.

Dental ingenuity through the ages.


Neodymium laser fusion of restorative materials to tooth structure. A preliminary report.


An autobiographical sketch.

An autobiographical sketch.


Dupuytren's contracture: a review.

Dupuytren's contracture: a review.


Psychopathology in systemic lupus erythematosus. II. Relation to clinical observations, corticosteroid administration, and cerebrospinal fluid C4.


Rheumatoid factors in families.

Rheumatoid factors in families.


Psychopathology in systemic lupus erythematosus. I. Psychiatric observations.


The treatment of stomatitis protetica granulomatosa with electrosurgery and two temporary reliners.


The effect of chlorhexidine emulsion on plaque. An intraindividual study of local application.


A physiological study of byssinosis in colonial America.


Gustatory receptor mechanism in mammals.


Tension at the surface of sea urchin eggs on the basis of "liquid-drop" concept.


Genetic study on transfer RNA.

Genetic study on transfer RNA.


Electronic structure of nucleic acid bases: their spectroscopic properties, chemical reactivities, and biological activities.


An immunofluorescent study of tumors with specific antisera for squamous epithelial intercellular substance and basement membrane.


The clotting time--an enigma.

The clotting time--an enigma.


Ca spike.

Ca spike.


The effect of microbial contamination of the blood sample on the determination of ethanol levels in serum.


A clinical trial of long-term oral salbutamol in reversible diffuse airway obstruction.


Enterotoxigenic intestinal bacteria in tropical sprue.


David Milford Hume, M.D. 21 October 1917--19 May 1973.


Bubonic plague: detection of endotoxemia with the limulus test.


Selman Abraham Waksman, Ph.D. 22 July 1888-16 August 1973. Who "discovered" streptomycin?


Selman Abraham Waksman, Ph.D. 22 July 1888--16 August 1973. Streptomycin reported.


Azathioprine.

Azathioprine.


Clinical trials of thrombolytic agents in myocardial infarction.


Letter: Positive end-expiratory pressure therapy.


Interaction of some factors in the mechanism of inactivation of bacteriophage MS2 in aerosols. The mechanisms involving inactivation of bacteriophage MS2 in aerosols and the effect of protective substances in the spray-medium were studied after spraying from various NaCl solutions. Results with aerosols generated from the salt solutions showed that with higher salt concentration in the spray-medium higher concentrations of protective substances were needed to protect phage MS2 against aerosol inactivation. Phenylalanine, which has a protective action at low concentration, produced less protection in aerosol droplets that were supersaturated solutions of this substance or in which crystals of phenylalanine can be expected to form. Our results suggested that protection by peptone and phenylalanine was related to the concentration in the aerosol droplet after evaporation to equilibrium, whereas protection by the surface active agent OED (a commercial mixture of oxyethylene docosylether and oxyethelene octadecylether) was related to the concentration at which a monolayer is formed around the aerosol particle. Inactivation of phage MS2 was maximal in the aerosol particle in fluid phase and became less at lower relative humidity where aerosol particles are expected to be in the solid state. It is suggested that inactivation of bacteriophage MS2 in aerosols could be explained by surface inactivation at the air-water interface.


Clinical trial of pentazocine in rheumatoid arthritis. Observations on the value of potent analgesics and placebos.


Direct fluorescent-antibody technique for the microbiological examination of food and environmental swab samples for salmonellae. Comparative studies of a modified fluorescent-antibody procedure and the 5 to 7 day method used by the Association of Official Analytical Chemists for the detection of Salmonella were made on 151 samples of wheat products and 183 swab samples. The agreement between the two methods for the 334 samples tested was 92.5%. Food samples yielded 94.7% agreement, whereas the swab samples yielded 90.7% agreement. There were 7.5% false positives for the total number of samples tested. No false negatives were obtained by using the fluorescent-antibody method.


Comparison of brilliant green agar and Hektoen enteric agar media in the isolation of salmonellae from food products. Brilliant Green (BG) agar and Hektoen enteric (HE) agar media were compared for their efficiency in isolating salmonellae from various food products. Of the 11,226 food specimens examined, 1,662 (or 14.9%) yielded salmonellae. Of this number, 1,475 (88.7%) were recovered from BG agar and 1,315 (79.1%) were recovered from HE agar media. The results indicate that BG agar is more effective in isolating salmonellae from food products. A smaller subsidiary study showed HE agar to be more selective than BG agar. Four hundred ten specimens yielded 92 nonlactose-fermenting isolants other than salmonellae on BG agar and only 11 such isolants on HE agar.


Escherichia coli field contamination of pecan nuts. More pecan samples collected from grazed orchards were contaminated with Escherichia coli than were samples from nongrazed orchards. No differences in frequency of contamination between mechanically and manually harvested nuts occurred. Nutmeats from whole uncracked pecans that were soaked for 24 h in a lactose broth solution containing E. coli did not become contaminated. Twentyfour percent of the whole pecans soaked in water for 48 h to simulate standing in a rain puddle developed openings along shell suture lines which did not completely close when the nuts were redried.


Comparison of Gelman and Millipore membrane filters for enumerating fecal coliform bacteria. Tests of two leading brands of membrane filters used for enumerating fecal coliform bacteria showed that Gelman GN-6 filters recovered statistically more colonies of bacteria than did Millipore HAWG 047SO filters from pure cultures incubated at either 35 C (the optimal growth temperature) or 44.5 C (the standard temperature for the fecal coliform test). Standard membrane filter procedures with M-FC broth base were used to enumerate the organisms. Densities of colonies incubated on Gelman filters at 44.5 C averaged 2.3 times greater than those on Millipore filters. Plate counts of the bacteria at both temperatures indicated that incubation at 44.5 C did not inhibit propagation of fecal coliform bacteria. For the pour plates, M-FC broth base plus 1.5% agar was used. This modified medium compared favorably to plate count agar for enumerating Escherichia coli. At 35 and 44.5 C, colony counts on Gelman filters agreed closely with plate counts prepared concurrently, but Millipore counts were consistently lower than plate counts, especially at 44.5 C. Comparative analyses of river water for fecal coliform bacteria by the membrane filter technique gave results comparable to those for the pure cultures.


Biodegradation of phenylmercuric acetate by mercury-resistant bacteria. Selected cultures of mercury-resistant bacteria degrade the fungicide-slimicide phenylmercuric acetate. By means of a closed system incorporating a flameless atomic absorption spectrophotometer and a vapor phase chromatograph, it was demonstrated that elemental mercury vapor and benzene were products of phenylmercuric acetate degradation.


Phosphatase activity among Candida species and other yeasts isolated from clinical material. A group of 277 yeasts isolated from burned children and 14 reference strains were tested for phosphatase activity by using phenolphthalein phosphate substrates. Phosphatase activity was widely distributed among various species and strains representing seven genera. Candida albicans, which was the most common yeast isolated from clinical material, was notably absent in producing the enzyme, whereas Candida tropicalis was the most consistent, strong, and rapidly active phosphatase-producing organism. The characteristic enzyme activity of a selected isolate of C. tropicalis was demonstrated in the presence of concentrations of inorganic phosphate which inhibited enzyme activity of other species. The greater enzyme activity of C. tropicalis was not related to more rapid or greater cell growth or decrease in the pH of culture media. Extracellular constitutive heat-labile acid phosphatase was found in broth filtrates of C. tropicalis, C. krusei, and a strain of Staphylococcus aureus.


Evaluation of radiometric system for detecting bacteremia. An automated radiometric system (BACTEC, Johnston Laboratories) for detection of bacteremia was evaluated in parallel with a standard blood culture system in use in our laboratory. Of 1,445 blood cultures from 484 patients with possible bacteremia, 106 sets of cultures (excluding 39 presumed contaminated), representing 56 patients, were positive by both methods. The conventional system yielded 85 positive cultures from 48 patients, whereas the BACTEC system yielded 84 positive cultures from 43 patients. The BACTEC system failed to detect 22 cultures that were positive in the conventional system, and the conventional system failed to detect 21 cultures that were positive in the BACTEC system. The detection efficiency was generally equivalent in the two systems except for the lower detection rates of anaerobes and Enterobacter aerogenes by the BACTEC system and the lower detection rates of Torulopsis glabrata and, possibly, Pseudomonas sp. (group IVD) in the conventional system. The BACTEC system had a slight advantage over the conventional system in the time interval to detection of positivity. Approximately 20% of the positive cultures detected by the BACTEC system were detected on the first day of incubation compared with 7% by the conventional system. The recovery rates and detection times of anaerobes were less efficient by the BACTEC system than by the conventional system. It does not appear that the radiometric method has much advantage over available conventional methods.


Cultivation of mycoplasmas on cellulose ester substrates. The ability of mycoplasmas to grow on cellulose ester substrates was evaluated. Mycoplasma pneumoniae, M. hominis, M. arthritidis, M. gallisepticum, and Acholeplasma laidlawii grew on Millipore (mixed cellulose ester) filters and Sepraphore III (cellulose polyacetate) membranes.


Rodac plate-holding device for sampling surfaces during surgery. A Rodac plate-holding device has been developed to facilitate microbial surface sampling of supposedly sterile items in the operating room during surgery.


Shigella sonnei isolated from well water. A method is described which led to the isolation of Shigella sonnei from well water suspected of being the primary foci in a school-associated shigellosis outbreak.


Evaluation of the interference filter for use in rabies diagnosis by the fluorescent antibody test. When compared with primary filters widely used for rabies diagnosis by the fluorescent antibody test, an interference filter markedly increased specific staining intensity and contrast.


Isolation of porcine parvovirus from commercial trypsin. The isolation of porcine parvovirus from a lot of commercial 1:250 trypsin is reported and the method is described.


Viability of Actinomycetales stored in soil. About 1,800 Actinomycetales stored in soil for up to 20 years were checked for viability. About one-half were viable.


Susceptibility of the mouse intestine to heat-stable enterotoxin produced by enteropathogenic Escherichia coli of porcine origin. Ligated intestinal loops of mice were found suitable for the assay of heat-stable enterotoxin produced by enteropathogenic Escherichia coli strains of porcine origin; loops inoculated with heat-labile enterotoxin failed to react.


Efficiency of various growth media in recovering oral bacterial flora from human dental plaque. MM10 sucrose blood agar (MM10 SB agar), N(2)C agar, Schaedler agar (SH agar), and mitis salivarius agar (MS agar) were tested for their ability to recover human dental plaque flora by a continuous anaerobic procedure and by a conventional anaerobic method. MM10 SB agar yielded higher recovery of bacteria from plaque samples as determined by the enumeration of colony-forming units (CFU). The CFU on N(2)C agar, SH agar, and MS agar were lower than MM10 SB agar when the continuous anaerobic procedure was used. The superior performance of MM10 SB agar was much more apparent when used for the cultivation of dental plaque by the conventional anaerobic method. Under these conditions the counts were consistently higher on MM10 SB agar as compared to the other media tested. However, the differential counts of Streptococcus sanguis and S. mutans from carious plaque samples were in general comparable on all culture media. Deletion of blood from MM10 SB agar did not lower counts. The elimination of dithiothreitol from this medium resulted in a significantly lower recovery of bacteria from the plaque samples when cultured by the conventional anaerobic method. The storage of MM10 SB agar for varying periods of time aerobic conditions did not seem to affect its performance. These findings suggest that MM10 SB agar is an ideal culture medium for the isolation, nonselective enumeration, and differential counts of bacteria present in normal and disease-associated plaques.


Bacteriophage typing of Salmonella typhimurium by use of a mechanized technique. A new mechanized technique for the application of drops of phages on agar plates is described. Drops of equal size are delivered by needles with the aid of filtered pressurized air. The part of the device which is in contact with phage is interchangeable as a whole.


Plating efficiency for primary hamster embryo cells as an index of efficacy of fetal bovne serum for cell culture. Attachment and growth of mammalian cells plated at low cell density require optimum conditions for the cells to form colonies. Reliability, reproducibility, and validity of the plating efficiency test for evaluating cell culture sera were determined by measuring the plating efficiency of 37 lots of fetal bovine serum obtained from 8 suppliers (5 lots from each of 7, 2 lots from 1 supplier), by using hamster embryo fibroblasts plated at low cell density. The test revealed considerable variation between lots of serum and between suppliers. The five lots from some suppliers had consistently high plating efficiencies, whereas one or more lots from other suppliers had quite low efficiencies. The results were reproducible in repeated tests, and control experiments indicated that the test measured the efficiency of the test serum independently of the efficiency of the serum used for the primary outgrowth of the hamster embryo cells.


Rapid detection of contaminated intravenous fluids using the Limulus in vitro endotoxin assay. Intravenous fluids and administration sets may become contaminated with gram-negative bacteria during use and result in a life-threatening situation to the patient. The Limulus in vitro assay for endotoxin was used in two patients whose parenteral fluids had become contaminated with Pseudomonas aeruginosa. This test allowed rapid detection of the contaminated intravenous fluids and demonstrated a concomitant endotoxemia in both patients. The same strains of pseudomon were subsequently cultured from each patient's blood, intravenous catheter tip, and parenteral fluid and administration set. A different serotype of pseudomonas was unique to each patient, indicating two separate and unrelated cases of accidental contamination of the administration sets. Endotoxin-like activity was also demonstrated from several brands of commercial human serum albumin, which may contribute low-level activity detectable by the Limulus assay.


Effectiveness of septisol antiseptic foam as a surgical scrub agent. Septisol antiseptic foam (0.23% hexachlorophene in a 46% ethyl alcohol base) is a new surgical scrub agent for both primary and re-entry use that is designed to minimize the harsh effects to the skin of the conventional scrub while retaining effective antibacterial properties. A preliminary surgical scrub study of 1-week duration yielded an immediate reduction in resident flora of 92% from an average single scrub coupled with a residual bacteriostatic effect from repeated use that gave a plateau at 57% of the pretest resident population level. A separate study demonstrated complete elimination of both gram-positive and gram-negative transients from the skin with a single application of the product. In an 8-week surgical scrub study, equal effectiveness was shown between Septisol antiseptic foam and a standard 3% hexachlorophene detergent. However, Septisol antiseptic foam offers considerable advantage in minimizing the harsh effects to the skin of the conventional surgical scrub and results in a substantially lower hemic level of hexachlorophene in the user than that obtained with 3% hexachlorophene detergent. Sampling was conducted by the fingerprint impression plate technique of Gale.


Deoxyribonucleic acid hybridization studies on Flavobacterium meningosepticum. Seventeen flavobacteria, including 12 strains of Flavobacterium meningosepticum, were investigated to determine their genetic relationships by deoxyribonucleic acid (DNA)-DNA hybridization and guanine plus cytosine content. The percentage of binding among the strains tested ranged from 6 to 87%. There was no correlation between the serotype and DNA-duplex formation. The guanine plux cytosine content of the representative strains of the five serotypes ranged from 31 to 50%.


Medium for the isolation of Aeromonas hydrophila. A new differential medium, Rimler-Shotts, was tested with 109 isolates representing 13 genera of bacteria obtained from aquatic environments and animals. This medium was effective in presumptive identification of the strains of Aeromonas hydrophila examined, with 94% accuracy. Strains of Citrobacter which were hydrogen sulfide-variable could not be separated from A. hydrophila. This medium was designed to facilitate diagnosis of A. hydrophila infections in animals and humans.


Bacteriological survey of frozen meat and gravy produced at establishments under federal inspection. During visits to 34 federally inspected establishments producing frozen meat and gravy, 541 production line samples and 535 finished product units were collected for bacteriological analyses. It was found that more than 70% of the sets of finished product (10 units/set) produced under good manufacturing practices had: (i) four or fewer coliform-positive units, (ii) two or fewer Escherichia coli-positive units, (iii) three or fewer Staphylococcus aureus-positive units, and (iv) an aerobic plate count of fewer than 50,000/g (geometric mean of 10 units). All finished product units were negative for salmonellae.


Growth and virulence of Salmonella typhimurium grown in different foods. Experimental data indicate that the virulence of Salmonella typhimurium grown in different foods varies. The possibility exists, therefore, that ingestion of foods containing the same number of salmonellae may not constitute a similar health hazard.


Use of combusted natural gas to cultivate the anaerobic bacterial flora from the cecum contents of mice. The use of combusted natural gas as atmosphere for cultivation of the anaerobic bacterial flora from the cecum of mice is described. The combusted gas (inert gas) continuously flushes a glove box in which it is possible to cultivate a number of strict anaerobes from the cecum of mice.


Capillary tube catalase test.

Capillary tube catalase test. A capillary tube procedure for detection of catalase activities of isolated colonies of pure and mixed cultures on nutrient and blood agar plates is proposed.


The outcome problem in psychotherapy research. A historical review.


Method for comparing concentrations of the open-air factor. It is shown how concentrations of the open-air factor may be compared from day to day; this has not been possible previously.


Concurrence of anorexia nervosa and gonadal dysgenesis. A critical review with practical considerations.


Cholesterol gallstone dissolution. Current status.


Kidney donor selection by sodium pertechnetate Tc 99m flow patterns.


A simple surgical ligator.

A simple surgical ligator.


Life-sustaining canine hepatic autotransplants.


Hydrolytic enzymes in corneal graft reaction.


Letter: Cardiology and the computer.

Letter: Cardiology and the computer.


Editorial: Oxygen toxicity. Introduction to a protective enzyme: superoxide dismutase.


Regional myocardial blood flow in patients with residual anterior and inferior transmural infarction.


Hypertension, antihypertensive drugs and atherosclerosis.


Inherent growth capacity of chicken heart myoblasts.


The calcium content of the cellular slime mold, Dictyostelium discoideum, during development and differentiation.


Partition of rat liver cells in aqueous dextran-polyethylene glycol phase systems.


Methods for quantitating sea urchin sperm-egg binding.


Characterization of temperature-sensitive mutants of yeast by a photomicrographic procedure.


Effect of methioninyl adenylate on the growth of E. coli K 12.


The primary structure of bovine growth hormone.


Irreversible binding of N-iodoacetylpuromycin to E. coli ribosomes.


Some properties of the organomercury-degrading system in mammalian liver.


Synthesis of phage M13 specific proteins in a DNA-dependent cell-free system.


Inactivation of bacterial ribosomes in vivo and in vitro by cloacin DF13.


Ribosome production and elongation factor activity during a nutritional shift-up in Escherichia coli.


Maturation of ribosomal RNA's in suspensions of higher plant cells a DNA-RNA hybridization study.


Does 5-fluorouracil cause catabolite repression?


The Christian Medical Society.

The Christian Medical Society.


Physiological effects of noise. An overview.


Increased adult auditory responsiveness resulting from juvenile acoustic experience.


The American Gastroenterological Association: history of its first seventy-five years.


Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo during the second or placebo during the first period and liquorice during the second. Only patients with chronic ulcer disease were accepted for the trial. The dosage of the liquorice extract was 760 mg three times daily. During the first period 38 patients with 47 ulcers in the ventricle and during the second period 30 patients with 36 ulcers took part in the trial. The patients' sex, age, site of the ulcer in the ventricle, and ulcer size in the groups treated with liquorice and placebo during periods I and II were similar. Nor could any difference be shown between the groups treated with liquorice and placebo with respect to heredity, duration of ulcer disease, alcohol consumption, smoking, or the use of drugs. There was no tendency to quicker healing in either group as regards change of ulcer area or complete healing. Small ulcers healed more quickly than big ones. Ulcers at the angulus healed very poorly. No side effects of treatment were observed.Our study was not able to demonstrate any healing effect of the liquorice extract (Caved-S) on gastric ulcer.


Who should regulate whom?

Who should regulate whom?


Progess report. Is secretin secreted?

Progess report. Is secretin secreted?


Format of the clinical laboratory of the future.


The direct enumeration of Escherichia coli in water using MacConkey's agar at 44 Cin plastic pouches.


Bacterial flora of synthetic carpets in hospitals.


Laboratory methods in the diagnosis of toxoplasmosis.


Barium-hypaque enemas--a reasonable approach? A controlled double blind study.


Effects of sucrose versus fat as energy source in the diet on rat liver polysome patterns.


Nutritional iron deficiency as a determinant of host resistance in the rat.


Use of statistical methods in evaluation of in vivo performance of dosage forms.


Estimation of diiodohydroxyquin in nonaqueous media.


Kinetics and mechanisms of drug action on microorganisms. XVII. Bactericidal effects of penicillin, kanamycin, and rifampin with and without organism pretreatment with bacteriostatic chloramphenicol, tetracycline, and novobiocin.


Germinal-cell loss in normal metazoan spermatogenesis.


Forebrain regulation of ovarian cycle in rats: evidence for a dual control.


Isolation of Clostridium botulinum type C from an outbreak of botulism in wild geese.


Toxoplasmosis in Egypt: isolation of Toxoplasma gondii from a pig.


Prostaglandins.

Prostaglandins.


The neural basis of food and water intake in birds.


Procion brown: an intracellular dye for light and electron microscopy. Procion browvn has been used to inject lamprey giant interneutros. The dye is opaque to both light and electrons, and imparts a pink color to the neuron in situ during iontophoresis. It has the advantage over cobaltolus chloride that postinjection treatment with ammonium sulfide is eliminated and the integrity of the surrounding neuropil is ensured.


Supraglottic laryngectomy.

Supraglottic laryngectomy.


Use of the autogenous jugular vein for interposition grafting in portal hypertension.


Malarial antibodies in tropical splenomegaly syndrome in Uganda.


Prevalence of antibodies to toxoplasma in a group of Ghanaians.


Giant follicular lymphoma of the stomach--report of 4 cases.


Genetic and phenetic classification of bacteria.


Mutation and the production of secondary metabolites.


Antimycin A, a piscicidal antibiotic.

Antimycin A, a piscicidal antibiotic.


Public health significance of feeding low levels of antibiotics to animals.


Ochratoxins.

Ochratoxins.


"On being the right size".

"On being the right size".


Cytofluorometric study of the deoxyribonucleoprotein of mouse spermatozoa early after fusion with Chinese hamster cells.


Zoosporic marine fungi (Thraustochytriaceae and Dermocystidiaceae).


Algal symbionts of invertebrates.

Algal symbionts of invertebrates.


Hybridization of eukaryotic cells.

Hybridization of eukaryotic cells.


Bacteriophage receptors.

Bacteriophage receptors.


Preparation and quantitative analysis of fungal cell walls: strategy and tactics.


The role of the host cell membrane in the replication and morphogenesis of bacteriophages.


The role of polymers in microbial aggregation.


Chemotherapeutic properties of heterocyclic compounds: monocyclic compounds with five-membered rings.


Aspects of microbiology in cancer research.


Plasmid determined resistance to antibiotics: molecular properties of R factors.


Test structure in foraminifera.

Test structure in foraminifera.


The starting nucleotide sequences and size of RNA transcribed in vitro on bacteriophage T3 DNA.


Comparison of coenzymatic activities of 2-nor-2-hydroxymethyl pyridoxal 5'-phosphate for mitochondrial and cytoplasmic aspartate aminotransferases.


The mechanism of inhibition of DNA synthesis in Escherichia coli by pyrimidin-2-one beta-D-ribofuranoside.


Raman studies of nucleic acids. X. Conformational structures of Escherichia coli transfer RNAs in aqueous solution.


Phenylalanine transfer RNA species in early development of barley.


Age-related changes in bone marrow hemopoiesis potential in mice.


A study of the filarial rosettes test.

A study of the filarial rosettes test.


Skeletal and heart muscle antibodies in myasthenia gravis. A new immunofluorescence pattern.


The catabolism of catecholamines. Recent studies.


Multiple forms of mitochondrial monoamine oxidase.


Uptake of noradrenaline by smooth muscle.


Histochemical visualization of peripheral and central adrenergic neurones.


Influence of selection of patients on results of clinical trials. The hypothesis is advanced that any population of patients can be divided into those with a good prognosis, a poor prognosis, and an intermediate prognosis in respect to a particular treatment. The outcome of a clinical trial of treatment will be partly determined by the proportion of patients selected for the trial from each of these prognostic groups. The implications of the hypothesis are illustrated by consideration of three recent trials of treatment for psychiatric patients.


Comparative trial of a new anticholinergic bronchodilator, Sch 1000, and salbutamol in chronic bronchitis. In 20 patients with chronic bronchitis and moderate or severe airways obstruction inhalation of 40 mug of a new anticholinergic drug, Sch 1000, was found to produce stronger and more persistent bronchodilation than inhalation of 200 mug of salbutamol.


Letter: Delayed attacks of malaria in visitors to the tropics.


Letter: Edrophonium in diagnosis of cholinergic crisis.


Air Commodore R.L. Soper.

Air Commodore R.L. Soper.


W.R. May.

W.R. May.


P. W. H. Bleasdale.

P. W. H. Bleasdale.


J. J. Healy.

J. J. Healy.


Growth inhibition of Escherichia coli strain 82-r by d-camphor.


Cultural characterization and differentiation of nocardiae.


Virulence of nocardiae.

Virulence of nocardiae.


Corynebacterium cyclohexanicum n. sp.: a cyclohexanecarboxylic acid utilizing bacterium.


Clean air symposium. I. Clean air in the operating room.


Analysis of immunological reactivity in skin-allograft tolerating rats.


Increasing incidence of group B beta hemolytic streptococci from human sources.


Immunosuppression after single and multiple pulse doses of 7,12-dimethylbenz(a)anthracene in the rat.


Mannitol infusion in burns; preliminary report of a clinical trial.


Manganese stimulates adhesion and spreading of mouse sarcoma I ascites cells. Adhesion of Sarcoma I cells (SaI) to untreated or to serum-treated glass was examined by layering (51)Cr-labeled cells on the substrate for 20 min at 34 degrees C and determining the glass-bound radioactivity after the monolayers were rinsed. Adhesion to untreated glass proceeded in sodium chloride-imidazole-potassium medium (SIK) without added divalent cations, whereas SaI adhered maximally to the serum-coated substrate only in the presence of 50 microM or more Mn. Divalent Mg, Ca, Co, Ni, or Zn were inactive or minimally active. Mn-stimulated adhesion was sharply temperature dependent, reversible upon removal of Mn, and inhibited by Ca as well as by cytochalasin B, vinblastine, or tetracaine. Adhesion of SaI in SIK did not ensue when cells or the coated substrate were pretreated with Mn and washed in SIK before the adhesion assays. Microscope observations showed that Mn induced the formation of cell processes, ruffles, and veils, and that SaI spread on the uncoated or serum-coated substrate when exposed to Mn. Cells withdrew veils and processes and rounded up when postincubated in Mn-free medium. Formation of cell processes and spreading was inhibited by cytochalasin B, vinblastine, or tetracaine. Manganese-induced adhesion seems to require the participation of microtubules and microfilaments and may be mediated by an effect of Mn on Ca fluxes. The results support the role of cell processes and spreading in cell-to-substrate adhesion.


Protein absorption by renal cells. II. Very rapid lysosomal digestion of exogenous ribonuclease in vitro.