Experimental aspergillosis in mice: aspects of resistance. Intravenous inoculation of Aspergillus fumigatus spores was used to study experimentally induced and natural resistance. Slight resistance resulted in increased survival time and higher resistance produced in addition a decreased infection rate.Sublethal doses of living spores gave significant protection against challenge 3 weeks later, but large doses of heat-killed spores had no demonstrable effect.Mice from one source showed a single, dramatic decrease in dose response to a deep-frozen strain of the organism over a period of 34 months. The dose response initially resembled that described by Scholer (1959) in which one million spores killed the majority of mice. The change was almost certainly due to an increase in resistance of the mice due to environmental factors, and the resistance was probably also effective against other strains of the organism. Although not proved, it seemed likely that the resistance was due to increased natural contact with A. fumigatus or related fungi. Possibly for a similar reason, mice of the same stock bred on different premises differed in their susceptibility to infection. The results indicated that environmental resistance-producing factors may have been operating simultaneously on a number of premises housing laboratory animals in south-east England. These findings may have significance in relation to the occurrence of natural aspergillosis of mammals and birds.Of five A. fumigatus strains, four were of closely similar virulence; the fifth strain grew more slowly in vitro and was somewhat less virulent. Isolates from mice which died sporadically after small doses of spores were of no greater virulence than the inoculated strain. Although the susceptibility of mice aged 3 weeks was not uniform under all conditions, such animals were less resistant than young adult mice. Mice from six different sources showed only slight differences in susceptibility between each other, or from mice known to have developed a natural resistance.


Accidental hypothermia.

Accidental hypothermia.


Total glossectomy for advanced carcinoma of the base of the tongue.


History of the Royal Naval Hospital, Plymouth. II. A walk around the Hospital.


Respiratory stimulation with intravenous doxapram in respiratory failure. A double-blind co-operative study.


Burns.

Burns.


A single dermal pedicle for nipple transposition in subcutaneous mastectomy, reduction mammaplasty, or mastopexy.


Effective hemostasis with less epinephrine. An experimental and clinical study.


Coverage of scalp and skull defect in a patient with the systemic form of scleroderma. Case report.


The present status of keratoprosthesis.

The present status of keratoprosthesis.


Radical perineal resection for far-advanced lymphogranuloma venereum. Case report.


Autonomy of mitochondria in Saccharomyces cerevisiae in their production of messenger RNA. In ts(-)136, a temperature-sensitive mutant of Saccharomyces cerevisiae, nuclear and mitochondrial RNA production can be inhibited selectively by exposure to 36 degrees and ethidium bromide, respectively. Using the programming of mitochondrial polysomes, as measured by their ability to form nascent polypeptide chains, as an assay for functional messenger RNA, we have determined its response to temperature shifts and ethidium bromide. Only ethidium bromide produced a measurable effect; in contrast the cell-sap system responded exclusively to temperature shifts. We conclude that transcription of mitochondrial DNA is sufficient and that import of messenger RNA transcribed from nuclear chromosomes makes no measurable contribution to intramitochondrial protein synthesis.


Ultraviolet-stimulated DNA synthesis in toluenzied Escherichia coli deficient in DNA polymerase I. Ultraviolet (UV)-stimulated nonconservative DNA synthesis has been observed in E. coli rendered permeable to nucleoside triphosphates by exposure to toluene. This synthesis is detected in toluenized cells in which the background of UV-independent DNA synthesis is reduced by use of dnaB mutants temperature-sensitive for DNA replication and additionally deficient in DNA polymerase I. UV-stimulated nonconservative synthesis is also seen in polA dnaE mutants that are deficient in two of the three known DNA polymerases. The observed UV-stimulated repair-like synthesis requires the presence of the four deoxyribonucleoside triphosphates and ATP. This mode of synthesis appears to differ from the ATP-independent nonconservative DNA synthesis previously reported to occur in toluenized bacteria.


Colicin E3: a unique endoribonuclease.

Colicin E3: a unique endoribonuclease. The question of whether or not a cellular ribonuclease is involved in the cleavage of 16S ribosomal RNA by colicin E3 was investigated. For this purpose ribosomes from strains devoid of some ribonucleases or ribosomes in which ribonucleases had been inactivated by heat or removed by extensive washings were used for the colicin reaction. Since the 16S RNA of all these different ribosomes, and even of the most extensively washed ribosomes, was cleaved by colicin E3, it is suggested that cellular ribonucleases are not involved in colicin E3 action. Thus, colicin E3 seems to be a unique endoribonuclease.


Identity of the ribosomal proteins involved in the interaction with elongation factor G. Rabbit antibodies produced against 50 of the 55 individually purified ribosomal proteins of Escherichia coli were tested for their ability to interfere with the formation of the ribosome.EF-G.GDP complex. Only antibodies produced against proteins L7 and L12 inhibited complex formation, and they did so completely. These two proteins were previously shown to be immunologically indistinguishable and necessary for the interaction between ribosomes and EF-G. The present data are consistent with the view that the interaction between ribosomes and EF-G that results in GTP hydrolysis occurs on, and is limited to, proteins L7 and L12 on the surface of the 50S ribosomal subunit.


Cleavage of adenovirus type 2 DNA into six unique fragments by endonuclease R-RI. The DNA of adenovirus type 2 was cleaved by restriction endonuclease R.RI into six fragments. These fragments were separated by electrophoresis on composite agarose-polyacrylamide gels. Their molecular weights ranged from 1.1 x 10(6) to 13.6 x 10(6), as measured by electron microscopy. Each fragment represented a unique segment of adenovirus type 2 DNA since: (i) the fragments were obtained in equimolar amounts; (ii) the sum of their molecular weights was equal to the molecular weight of complete adenovirus DNA; and (iii) each fragment exhibited a rate of renaturation that was inversely proportional to its size.


Transfer RNA synthesis in vitro.

Transfer RNA synthesis in vitro. During infection of Escherichia coli, bacteriophage T4 directs the synthesis of at least eight transfer RNAs and of two stable RNA species of low molecular weight, of unknown function. When T4 DNA is incubated with purified RNA polymerase and the appropriate substrates, a high molecular weight RNA is produced. This RNA, on further incubation with a supernatant fraction prepared from E. coli, is cleaved to several species of RNA. These cleaved RNAs were analyzed by gel electrophoresis and fingerprint techniques, and were found to be similar or identical to those made in vivo. The fingerprint analysis of one of these, a tRNA(Gly), is presented. The molecule made in vitro, except for the absence of modified bases, appears to be identical to the RNA made by T4-infected cells. Therefore, in this system the tRNA genes are transcribed with fidelity, the transcript is cleaved correctly, and the tRNAs are made in good yield.


A coat protein of the bacteriophage M13 virion participates in membrane-oriented synthesis of DNA. Several molecules of a protein specified by gene 3 of M13 comprise a minor fraction of the phage coat and have been assigned a role in adsorption to the bacterial cell. We find that the gene-3 protein molecules of the virion are fully conserved in phage that have attached irreversibly to the host cell, and they form a complex with the phage DNA when it has been converted to a duplex replicative form. In cells infected at a restrictive temperature with a thermosensitive mutant in gene 3, there is no conversion of the phage DNA to the replicative form. Both the adsorbed phage and the complex of replicative form DNA with the gene-3 protein were isolated with the inner membrane fraction of the cell. We suggest that the gene-3 protein may perform an essential function in the synthesis of replicative form by linking the phage DNA to a cellular replicative system in or on the inner cell membrane.


Alteration of ribosomal protein S4 by mutation linked to kasugamycin-resistance in Escherichia coli. An alteration in the chromatographic mobility of 30S ribosomal protein S4 from two kasugamycin-resistant (ksgA) strains of E. coli was observed. The locus determining this alteration frequently cotransduced with ksgA but could be separated from it by transduction and conjugation. Since the structural gene for protein S4 is thought to lie some 30 min from ksgA on the E. coli chromosome, the product of the newly-identified gene may modify protein S4. We propose to designate this gene ramB.Reconstitution of 30S subunits from RNA and protein components of ksgA ramB and ksgA(+)ramB(+) strains demonstrated that ribosomal resistance to kasugamycin was due to altered 16S RNA and not to altered protein S4. The altered 16S RNA was undermethylated, and a methylating enzyme that acts on 16S RNA from ksgA strains was present in ksgA(+) but not in ksgA strains.


Mechanism of protein chain termination: further characterization of a mutant defective in a new protein synthesis factor. Mutant N4316 is conditionally lethal at 43 degrees . At 36 degrees it suppresses the termination codons UGA and UAA, but not the UAG codon or a missense mutant of T4 bacteriophage. In vitro, a factor rescues protein synthesis from a temperature-dependent arrest when N4316 extracts are used with RNA from bacteriophage f2. Analyses of the substrate in the arrested synthesis and of the product of the rescue reaction indicate that the factor works at the level of coat protein termination, and that it also affects the synthesis of noncoat protein products. The rescue factor is different from the release factors RF-1, RF-2, and RF-3. Model systems previously used to study release fail to score for at least one vital function in protein chain termination.


RNA-linked DNA fragments in vitro.

RNA-linked DNA fragments in vitro. RNA-linked DNA fragments are intermediates in DNA replication in Escherichia coli cells made permeable to nucleoside triphosphates by treatment with toluene. Covalent linkage of a short RNA stretch to the 5' end of the DNA is proved by transfer of (32)P from [alpha-(32)P]dNTP to ribonucleotides upon digestion with alkali or pancreatic RNase, and by a small decrease in the molecular size upon alkaline hydrolysis. The (32)P transfer experiments reveal a unique structure...p(rPy)p(rA)p(rU or rC)p(dC)p... at the RNA-DNA junction.


The art and science of contemporary drug development.


The chemotherapy of intestinal nematodes.


Biochemical acyl hydroxylations.

Biochemical acyl hydroxylations.


Studies on the immunity of the calf to colibacillosis. V. The experimental reproduction of enteric colibacillosis.


The thymus as an endocrine gland.

The thymus as an endocrine gland.


Zinc in serum and urine in hemoblastosis and malignancy.


Patterns of antinuclear antibody fluorescence in leucocytes and hepatocytes.


Proteus mirabilis osteomyelitis in two neonates following needle puncture. Successful treatment with ampicillin.


Liver abscess in newborn. Complication of umbilical vein catheterization.


Gilbert B. Forbes, MD, chief editor.

Gilbert B. Forbes, MD, chief editor.


Transfusion-induced malaria. Plasmodium vivax in a 5-month-old child.


Immune response in vitro of lymphocytes attached to macrophages and lymphocytes in suspension.


Asymptomatic and symptomatic urinary tract infection in infancy.


George N. Papanicolaou--some reminiscences.


Passive immunization of calves against experimentally induced enteric colibacillosis by vaccination of dams.


Chronologic development of streptococcic lymphadenitis in swine.


Viability tests in exfoliated cells from vaginal and oral epithelia.


Critical variables in the radioimmunological technique for measuring immunoreactive insulin with use of immunosorbents.


The child with terminal transverse partial hemimelia: a review of the literature on prosthetic management.


The call of comparative biochemistry (Marcel Florkin).


Mattress suture otoplasty: a histopathologic study.


Lowered transplantability of cultured tumor cells by persistent infection with paramyxovirus (HVJ).


Secretin: a long progress note.

Secretin: a long progress note.


Strand breaks in deoxyribonucleic acid of thymine-starved bacteria.


Sedimentation of single human red blood cells. Differences between normal and glutaraldehyde fixed cells.


Formation in agar of fibroblast-like colonies by cells from the mouse pleural cavity and other sources.


Treatment of a deviant pattern of functional closure.


Drinking water not adequate source of fluorides.


Heterologous antiserum to mouse thymus-derived lymphocytes.


The acid-etch restoration: a treatment for fractured anterior teeth.


Dentigerous cysts associated with second mandibular bicuspids in children: report of five cases.


Adjuvant effect of endotoxin; antibody response to sheep erythrocytes in mice after transfer of syngeneic lymphoid cells treated with bacterial lipopolysaccharide in vitro.


Differential sensitivity of bone marrow and thymus cells to actinomycin D in the in vivo response of mice to sheep erythrocytes.


Polycarbonate sieve filtration of lymph node cells: selective depletion of immunoglobulin-bearing lymphocytes.


Oral manifestations of the histiocytosis X syndrome: report of two cases.


A five-film oral radiographic survey for children.


Hyper-labile messenger RNA in polar mutants of the tryptophan operon of Escherichia coli.


Subunits of RNA polymerase in function and structure. II. Reconstitution of Escherichia coli RNA polymerase from isolated subunits.


Bilateral connation of primary molars: report of a case.


The lac repressor-operator interaction. VII. A repressor with unique binding properties: the X86 repressor.


General model of myosin filament structure. II. Myosin filaments and cross-bridge interactions in vertebrate striated and insect flight muscles.


All in the family.

All in the family.


Replication of bacteriophage M13. VII. Requirement of the gene 2 protein for the accumulation of a specific RFII species.


High-resolution x-ray diffraction studies on a pure species of transfer RNA.


Ankylosis of primary molar teeth. I. Prevalence and characteristics.


Local action of progesterone leading to polyspermic fertilization in pigs.


The effect of hypothalamic gonadotrophin releasing hormones on the secretion of luteinizing hormone from the pituitary gland of the domestic fowl.


Peer review.

Peer review.


The response of the reproductive system in the female mutant mouse, obese (genotype obob) to gonadotrophin-releasing hormones.


Effects of thyroxin on ultrastructure of rat myocardial cells: a stereological study.


Striated filamentous bundles associated with centrioles in pulmonary lymphatic endothelial cells.


Glycogen, its chemistry and morphologic appearance in the electron microscope. I. A modified OsO 4  fixative which selectively contrasts glycogen.


Lymphocyte mediators and cellular hypersensitivity.


Hepatic trauma.

Hepatic trauma.


Thyroid eponymy.

Thyroid eponymy.


Diet and drugs in renal acidosis and acid-base regulation.


Studies on the absorption of halogenated hydrocarbons and their excretion in breath using 38 Cl tracer techniques.


Modern concepts of the role of nephrotoxic agents in the pathogenesis of acute renal failure.


Toxic nephropathy due to drugs, solvents and metals.


Chronic effect of analgesics on the kidney.


Recent advances in therapy. Antihypertensive and antibacterial agents.


Antilipaemic drugs and nephrotic hyperlipidaemia.


Reverse isolation in bone marrow transplantation: ultra-clean room compared with laminar flow technique. I. Isolation systems.


Diet, drugs and dialysis in the management of chronic renal failure.


Diabetes through the ages: a salute to insulin.


Hirschsprung's disease in the newborn.

Hirschsprung's disease in the newborn.


Gastric ulcerations.

Gastric ulcerations.


Current management of thermal burns.

Current management of thermal burns.


Localisation and synthesis of  -fetoprotein in the rabbit.


Alteration of Shigella pathogenicity by other bacteria.


The occurrence of hemolytic streptococci in school children in Nashville, Tennessee, 1961-1967.


The periodicity of insulin secretion by islets of Langerhans shown by using a new apparatus. Preliminary data.


The obligation to observe and to record.


Thomas Addison; teacher, diagnostician and chest physician.


The expectorant effect of glyceryl guaiacolate in patients with chronic bronchitis. A controlled in vitro and in vivo study.


Multiple sclerosis. Current etiological concepts. An animal model for acute multiple sclerosis (ms) is experimental allergic encephalomyelitis (eae). eae is produced by intradermal injection of a protein component of central nervous system (cns) myelin. Ultrastructural studies of eae and of a peripheral nerve analog, experimental allergic neuritis (ean), have revealed an orderly sequence of cellular events leading to the destruction and removal of myelin with sparing of axons (primary demyelination). Acute ms has not been studied electron microscopically, but the ultrastructural similarities between ean and a case of acute Landry-Guillain-Barré syndrome, a primary demyelinating disease of the peripheral nervous system, suggest that a similar sequence of events might be found in acute ms. While the pathological findings support a cellmediated or delayed hypersensitivity response, there is also evidence for the pathogenetic role of circulating antibodies. Among such evidence is included the finding that sera from animals with eae and humans with acute ms rapidly produce a reversible block of complex (polysynaptic) electrical activity when applied to cns tissue cultures, which suggests a possible mechanism for transient symptoms in ms. Epidemiological and other studies link ms with a viral cause, although no direct evidence that ms is caused by a virus exists. Viral and immunological mechanisms are not mutually exclusive in considering pathogenetic possibilities for ms, for it can be postulated that a viral infection of the central nervous system acts as a triggering agent for a series of immune responses, including production of a bioelectric blocking antibody and demyelination mediated by sensitized cells, the combination of which ultimately produces the total clinical picture of ms.


Mechanisms of action of antiarrhythmic drugs.


Reflex increases in heart rate elicited by stimulation of afferent cardiac sympathetic nerve fibers in the cat.


Biochemical transformation of pesticides by soil fungi.


Interactions of halogenated pesticides and microorganisms: a review.


Activity, ecology, and population dynamics of microorganisms in soil.


Self concept and the retarded: research and issues.


Alfred A. Strauss: pioneer in learning disabilities.


Spheroplast-like structures in Escherichia coli demonstrated by scanning electron microscopy.


Bicyclomycin, a new antibiotic. 3. In vitro and in vivo antimicrobial activity.


Plasmid-mediated gentamicin resistance not associated with kanamycin resistance in Enterobacteriaceae.


Louping-ill encephalomyelitis in the sheep. VI. Infection of the 120-day foetus.


An immuno-histological study of the immunological response of the rat to infection with Trichinella spiralis.


Uterine infections caused by bacteria and mycoplasma in mice and rats.


Specific labelling of thiol groups in mammalian keratin suitable for electron microscope studies.


An inexpensive device for increasing the usefulness of the comparison eyepiece in examining slide-mounted ectoparasitic insects.


[The evolution of the surgical treatment of coronary arteriosclerosis].


Anterior cerebro-vascular insufficiency: usefulness of ophthalmodynamography in diagnosis and postoperative control.


Efficiency of protein and messenger RNA synthesis in bacteriophage T4-infected cells of Escherichia coli.


Bacteriophage T4 transfer RNA. 3. Clustering of the genes for the T4 transfer RNA's.


Role of ATP in DNA synthesis in Escherichia coli.


Isolation and physical mapping of T7 gene 1 messenger RNA.


Cardiopulmonary autotransplantation in primates.


Initiation factor IF-3: a specific inhibitor of ribosomal subunit association.


Isoleucylation of transfer RNA f  Met (E. coli) by isoleucyl-transfer RNA synthetase from Escherichia coli.


Different half-lives of messenger RNA corresponding to different segments of the tryptophan operon of Escherichia coli.


Metabolism of T4 messenger RNA, host messenger RNA and ribosomal RNA in T4-infected Escherichia coli B.


Distribution of closely linked markers following intragenic recombination in Escherichia coli.


Accumulation and turnover of guanosine tetraphosphate in Escherichia coli.


Observations on the structure of the termination factor rho and its attachment to DNA.


Non-suture intestinal anastomosis by invagination.


Crystallographic study of cytochrome b 562  from Escherichia coli.


Water quality models for total coliform.


Microbial decomposition of pentachlorophenol.


Bronchodilator aerosol. Comparison of administration methods.


Victor Manuel Calderon.

Victor Manuel Calderon.


High-dosage intravenously administered methylprednisolone in renal transplantation. A preliminary report.


Roentgenologic diagnosis of the brain by retouching roentgenograms with special reference to the subtraction and harmonization.


Bronchial smear in lung transplantation--early detection of rejection in canine lung allotransplantation.


Renal transaplantation in Michigan.

Renal transaplantation in Michigan.


Foundations for Medical Care.

Foundations for Medical Care.


Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects.


Hemodialysis for oxaluric renal failure.


New Jersey RMP for renal failure.

New Jersey RMP for renal failure.


Sir John Walsh--a tribute.

Sir John Walsh--a tribute.


A comparison of the heat production and mechanical efficiency of diamond instruments, stones, and burs at 3000 and 60,000 rpm.


Granulomas in edentulous jaws.

Granulomas in edentulous jaws.


Jaw cysts and the basal-cell naevus syndrome: cyst recurrence in a bone graft.


Pressure-indicating paste: 2 simple formulas.


Complications of pregnancy after renal transplantation including a report of spontaneous uterine rupture.


Cognitive factors in eyelid conditioning.


Reticulum cell sarcoma of the cervix.

Reticulum cell sarcoma of the cervix.


Mendel's elder friar and teacher, Matthew Klácel (1808-1882).


Who is Martin Buber?

Who is Martin Buber?


AAAS officers, committees, and representatives for 1973.


Cannabis and temporal disintegration in experienced and naive subjects. The effects of 3.3 and 6.6 milligrams of Delta(9)-tetrahydrocannabinol and of placebo on performance of three cognitive tasks were compared for naive subjects and experienced cannabis smokers. No differences in performance or reported subjective effects were found between these two groups. A significant decrement was found following dosage at both levels, replicating earlier findings of temporal disintegration during cannabis intoxication.


Pathogenesis of Shigella diarrhea. 3. Effects of shigella enterotoxin in cell culture.


New members.

New members.


Hiatus hernia. A review.

Hiatus hernia. A review.


The man with the cigar (Henry Smith).

The man with the cigar (Henry Smith).


The hypothalamus and reproduction.

The hypothalamus and reproduction.


Max Schapero, 1921-1972.

Max Schapero, 1921-1972.


Two experiences of an American public health nurse in China a quarter of a century apart.


A study of microflora on tiled and carpeted surfaces in a hospital nursery.


A tribute to Margaret G. Arnstein (1904-1972).


Riboflavin oversynthesis.

Riboflavin oversynthesis.


Schizophrenia and autoimmune serological reactions.


Oliver Wendell Holmes (1809-1894).

Oliver Wendell Holmes (1809-1894).


Morphogenetic and nutritional studies of Geotrichum lactis cells.


The psychiatrist in search of a science. I. Early thinkers at the Maudsley.


Hexafluorenium bromide: current status and a review.


Donald W. Benson, M.D.

Donald W. Benson, M.D.


Localization in Escherichia coli B of two enzymatic sites of action by 1-formylisoquinoline thiosemicarbazone (IQ-1) on ribonucleic acid biosynthetic pathways.


Biochemical studies of the effects of 1-formylisoquinoline thiosemicarbazone (IQ-1) in Escherichia coli B.


Clinical evaluation of a new chemical compound with antidepressant properties.


Acute poisoning by higher nitrogen oxides.


The future of psychiatry: predications past and present.


Mechanical failure of a ventilator: a case report.


The in vivo effect of halothane on rat splenic lymphocytes.


Circadian patterns of urine 17-OHC and VMA excretion during sleep deprivation.


A direct enzymic assay for 7 -hydroxy bile acids and their conjugates.


A clinical study of mesoridazine and chlorpromazine in relapsed schizophrenic patients.


Teichoic acids in cell walls and membranes of bacteria.


Current status of toxoplasma and toxoplasmosis: a review.


Health organization in the European Economic Community: an annotated bibliography.


A case for the computer: a history and a projection.


The palatine tonsils of the pig--an afferent route to the lymphoid tissue.


New samplers for collection of sea mud.

New samplers for collection of sea mud.


Geoffrey Wingfield Harris, C.B.E., F.R.S., M.D., B.Chir., Sc.D. (Cantab.).


Inactivation of 3',4'-dideoxykanamycin B by an enzyme solution of resistant E. coli and isolation of 3',4'-dideoxykanamycin B 2''-guanylate and 2''-inosinate.


New pepstatins, pepstatins B and C, and pepstanone A, produced by streptomyces.


The localization of vehicle bacteria in tissue.


A gradient of positional information in an insect, Rhodnius.


Sample sizes for clinical trials designed for patient accrual by cohorts.


Medical microbiology for patient and community.


Intravascular coagulation and renal failure in E. coli septicaemia.


Internal stent for securing large skin grafts on small animals.


Isolation of Aeromonas species from clinical sources. In a period of one year, in a general hospital, Aeromonas hydrophila was isolated from 13 patients and Aeromonas shigelloides from one patient. Eight of the patients had superficial infections, two had urinary tract infections, and four had bacteriaemia. The association of Aeromonas bacteriaemia with cirrhosis of the liver and malignant disease, which has been previously reported, was observed in three of the four bacteriaemic patients. The key to laboratory diagnosis of this genus is the routine performance of the oxidase test in bacteriological procedures for the identification of Gram-negative bacilli.


"Immunosuppressive" treatment of "chronic glomerulonephritis".


The hypothalamic median eminence as a neuroendocrine organ.


Phenformin and vascular complications of diabetes.


Darvon and Darvon-N.

Darvon and Darvon-N.


Pentazocine.

Pentazocine.


Oral contraceptives and thromboembolism.


Physiological and clinical studies with natural and synthetic luteinizing hormone-releasing hormone (LH-RH).


Reader reaction to the Kennedy autopsy report.


Furosemide (Lasix).

Furosemide (Lasix).


Ketamine hydrochloride. A second look.

Ketamine hydrochloride. A second look.


Candicidin for vaginal candidiasis.

Candicidin for vaginal candidiasis. Candicidin for treatment of vaginal candidiasis is discussed.  Candicidin has not been established as being superior to nystatin for cure or relief of monilial vaginal infections.  Since nystatin has been in use for years with only minor adverse affect and since it is less exp ensive than candicidin, it should still be the drug of choice.  If 1 or 2 courses of intravaginal and oral nystatin fail to cure (as tested by culture), candicidin is worth trying.  Unlike mystatin, candicidin is not available in an oral formulation.  Many "Medical Letter" consultants believe that cur of vaginal candidiasis is easier if patients stop taking oral contraceptives when the diagnosis is made.


Triclofos sodium (Triclos) for insomnia.


Bile salts in health and disease.

Bile salts in health and disease.


Historical data on the dynamics of lymphatic metastasis.


The genetic control of immunity and its relationship to carcinogenesis. A review.


Lethal and mutagenic action of formaldehyde in Hcr +  and Hcr -  strains of Escherichia coli.


An analysis of mitotic activity and the question of a thymus-like system in planarians.


Lithium and chlorpromazine: a controlled crossover study of hyperactive severely disturbed young children.


Methotrexate in the treatment of psoriasis.


Fables for the instruction of youth published in Boston in 1818. Excerpt VII: boy and the bees.


Schistosome ova deposits in the appendix. Qualitative and quantitative histopathological findings in bilharzial appendicitis.


Was Sir Walter Scott's lameness cauded by poliomyelitis?


Simplified screening for bacteriuria in children.


A case of recurrent pseudocyesis.

A case of recurrent pseudocyesis.


The adolescent patient's decision to die.


Surgical treatment of congenital myelomeningocele in newborns.


Hereditary pancreatitis: three new kindreds and a critical review of the literature.


Treatment of delirium tremens. A comparative evaluation of four drugs.


Certain anesthesiologic problems in urological operations.


Mechanisms of lymphorrhage into the serous cavities with description of a case.


Lyman Beecher and the temperance crusade.


Late results of posttraumatic suture of peripheral nerves of the lower extremity.


Late results of posttraumatic suture of peripheral nerves of the upper extremity.


Walt Whitman: a psychological and psychoanalytic bibliography.


Macrocyclic spermidine and spermine alkaloids.


Influence of chlorpromazine on emotional hyperreactivity resulting from septal forebrain injury.


Neuropsychological deficits associated with alcoholism. A review and discussion.


Urographic and angiographic abnormalities in adult-onset acute bacterial nephritis.


Comparative myocardial distribution patterns after intracoronary injection of cesium and labeled particles.


Rapid bolus injection of radioisotopes.

Rapid bolus injection of radioisotopes.


Vascular imaging with  99m Tc-red blood cells.


David Shields Carroll, B.S., M.D. President, Radiological Society of North America.


Fay Knight Alexander, M.D. 1903-1972.

Fay Knight Alexander, M.D. 1903-1972.


Charles Benkendorf, M.D. 1922-1972.

Charles Benkendorf, M.D. 1922-1972.


Radionuclide techniques for the evaluation of diseases of the urinary tract in children.


Liver and spleen scintigraphy in children.


Bataviae group leptospirae isolated from armadillos in Argentina.


A review of sex role research.

A review of sex role research.


Analytic review: some current problems of human population genetics.


Adult sex roles and mental illness.

Adult sex roles and mental illness.


Pulmonary lavage with liquid fluorocarbon in a model of pulmonary edema.


The use of mechanical ventilation with positive end-expiratory pressure in the treatment of near-drowning.


Some hemodynamic effects of sodium nitroprusside.


New York's first scientific body: The Literary and Philosophical Society, 1814-1834.


Estimation of microbial viability.

Estimation of microbial viability.


Inverse binomial sampling as a basis for estimating negative binomial population densities.


Anti-addictive chemotherapy--metronidazole and alcohol aversion.


Pyoderma gangrenosum with altered cellular immunity and dermonecrotic factor.


The inflammatory reaction in pityriasis lichenoides.


Insulin production and glucose tolerance in patients with granuloma annulare.


Double-blind trial of zinc sulphate in the treatment of chronic venous leg ulceration.


Effect of splenectomy on the induction of high degrees of tolerance to skin allografts in rats.


On the mode of action of thymosin.

On the mode of action of thymosin.


The multiple occurrence of myeloma and asymptomatic paraproteinaemia within one family.


Evaluation of cell mediated immune responses in untreated cases of leprosy.


Delayed skin reactions to cytoplasmic extracts of Nocardia organisms as a means of diagnosis and epidemiological study of Nocardia infection.


The serum level of vitamin B 12  in healthy and diseased children.


Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose).


Transfer of antigenic macromolecules from macrophages to lymphocytes. I. Autoradiographic and quantitative study of ( 14 C)endotoxin and ( 125 I)haemocyanin transfer.


The influence of preparturient intramammary vaccination on bovine mamary secretions. Antibody activity and protective value against Escherichia coli enteric infections.


Chemically defined media for mammalian eggs and early embryos.


Isolation of bacteriophages from commercial sera.


Growth of Chlamydia psittaci strain meningopneumonitis in mouse L cells cultivated in a defined medium in spinner cultures.


The differentiation of glial cells and glia limitans in organ cultures of chick spinal cord.


Derepression of isoleucine-valine biosynthetic enzymes and extracellular isoleucine accumulation in Serratia marcescens.


Sequence studies on the tryptic peptides and the chymotryptic peptides from the   polypeptide chain of aII component of the chicken hemoglobin. Biochemical studies on hemoglobins and myoglobins. 8.


Physico-chemical studies on conformation of a complex reconstituted from half molecules of Torulopsis utilis tyrosine transfer ribonucleic acid.


Biogenesis of cocarboxylase in Escherichia coli. Partial purification and some properties of thiamine monophosphate kinase.


Interaction of heavy meromyosin with substrate. VI. The difference absorption spectra induced by ATP analogs and 2-hydroxy-5-nitrobenzyl bromide.


Prostaglandin research: international co-operation between industry and university.


A renal dialysis and kidney transplantation program for the state of Maine.


Upjohn involvment with the prostaglandins: a brief history.


Hypospadias. Results with the Hodgson urethroplasty.


Auditory feedback as a major factor in stuttering.


Prostaglandin F 2   and oxytocin for term labor induction.


Urinary reconstruction by pyeloureteral anastomosis in human renal transplants.


Jerome Fracastoro. Physician, Philosopher, and Poet.


The three-kidney rat. Renal isografts and renal counterbalance.


The management of severe renal lacerations.


V-ileal loop.

V-ileal loop.


Ileocecal substitute bladder. Long-term followup.


Bladder flap incorporating the intact ureterovesical junction.


Congenital curvature of the penis. Successful results with variations in corporoplasty.


Comparison of the conservative and surgical management of the more severe degrees of renal trauma in multiple injured patients.


Electrophoretic and other properties of bacteriophage Q : the effect of a variable number of read-through proteins. When subjected to electrophoresis in polyacrylamide gels, the virions of wild-type Qbeta bacteriophage are found in a single, major, anomalously wide band. With Qbeta mutant 27-2, this wide band is replaced by a set of narrow, well-defined bands. The most rapidly migrating band of the mutant, comprising less than 10% of the total, contains defective virions. These virions have sedimentation coefficients ranging from 70 to 100% of the bulk of the unfractionated mutant, they contain no read-through protein (protein IIb), and they are deficient in maturation protein and contain fragmented RNA. The second band, comprising less than 3% of the total virus, has not been well characterized. The virions in the remaining electrophoretic bands are infective. Their distribution into bands is believed due to differences in their effective volume resulting from differences in their content of protein IIb. The most rapidly migrating band of this series contains virions with a few molecules of IIb protein, whereas the more slowly migrating bands contain virions with a larger number of IIb molecules. The adjacent bands in the series contain virions which differ by approximately three IIb molecules. Wild-type Qbeta virus is similar to the mutant in that the more slowly migrating virions contain more protein IIb than the more rapidly migrating virions. Their failure to resolve into distinct bands upon electrophoresis is believed due to a less restricted packing of protein IIb into their virions. Both wild-type Qbeta and mutant 27-2 also have 1 to 5% of the virions in the form of dimers which migrate with approximately one-half the mobility of the respective monomer forms. When the average amount of IIb per virion is increased by growth of the virus in a UGA suppressor strain, the electrophoretic pattern is altered. In the case of wild-type Qbeta, the single band is wider, whereas with Qbeta mutant 27-2 there occurs an increased number of partially resolved narrow bands. We suggest that the structural feature responsible for the difference in electrophoretic pattern between mutant 27-2 and wild-type Qbeta is the mode of IIb packing in the virions. In the mutant, the IIb proteins are found in the virions only in multiples of three, whereas wild-type virions may differ by only a single IIb protein.


T-even bacteriophage-tolerant mutants of Escherichia coli B. 3. Nature of the tet defect. T-even phage-tolerant (tet) mutants of Escherichia coli B are shown to lack the enzyme uridine diphosphoglucose pyrophosphorylase and thus produce nonglucosylated progeny phage deoxyribonucleic acid.


Suprapubic closure of vesicovaginal fistula.


Aortocoronary bypass with saphenous vein graft. Seven-year follow-up.


Infectivity of lambda heteroduplex deoxyribonucleic acid molecules. Heteroduplex deoxyribonucleic acid (DNA) molecules were formed in vitro by denaturing and renaturing a mixture of DNAs from a variety of lambda strains. The infectivity of these heteroduplexes was studied by using host-controlled modification and restriction to prevent infection by contaminating parental homoduplexes. Either strand was able to protect against degradation by restriction nucleases in vivo. A large proportion of progeny phage, which had been produced after infection with heteroduplexes containing noncomplementary base pairs at multiple loci, retained the genotype of one of the parental homoduplexes. The results indicate that conversion of heteroduplexes to homoduplexes in vivo by a DNA repair mechanism does not occur frequently. Molecules heterozygous for the c17 or vir operator mutations were not infectious; it is suggested that these mutations involve multiple base pairs.


Immunofluorescent test for lupus erythematosus: relation to renal disease.


Superinfection exclusion by incomplete genomes of bacteriophage T4. The genetic basis of superinfection exclusion by bacteriophage T4 was investigated by using incomplete genomes derived from the gene 66 mutant E920g. Incomplete genomes, which included a region of T4 between genes 42 and 44, were able to exclude superinfecting phage with an efficiency similar to that of complete genomes. Those genomes which did not include this region were unable to exclude superinfecting phage. A mutant with reduced ability to exclude super-infecting phage was isolated after mutagenesis with hydroxylamine. The mutation maps midway between amN122 in gene 42 and amB22 in gene 43. The efficiency of exclusion of superinfecting phage (as measured by the percentage of superinfected cells which failed to release any phage carrying selected markers of the superinfecting phage) by this mutant was 50 to 60%, whereas for wild type it was 85 to 95%. Uptake of (3)H-leucine by cells infected with the mutant was inhibited by superinfection with ghosts and it has therefore been designated imm1, for lack of immunity to superinfecting phage and ghosts. The formation of infective centers by cells infected with imm1 or another imm(-) mutant (imm2) was not inhibited by superinfection with ghosts.


Ligase-defective bacteriophage T4. I. Effects on mutation rates. Temperature-sensitive mutations in bacteriophage T4 gene 30 (polynucleotide ligase) were examined for their effects on spontaneous and proflavine-induced frameshift mutagenesis in the rII and ac (acridine resistance) cistrons. Only small (fourfold or less) effects on mutation rates were observed, even when selection artifacts involving suppression of gene 30 mutations by rII mutations were taken into account. The deoxyribonucleic acid ligase gene of T4 therefore appears to be only a minor determinant of frameshift mutation rates. This result is consistent with the particular nature of frameshift mutagenesis in bacteriophage T4.


Ligase-defective bacteriophage T4. II. Physiological studies. The timing of the suppression of gene 30 (deoxyribonucleic acid ligase) mutations by rII mutations was studied by temperature shift-down experiments with a temperature-sensitive rII mutation. The rII function must remain inactivated for about 5 to 8 min at 37 C for suppression to occur, thus making suppression an early function. This result is in agreement with the timing of expression of other rII functions. A gene 30 defect can also be overcome by replacing the Na(+) cation in the growth medium with the Mg(2+) cation, a result similar to the relief of the lethality of rII mutations in lambda lysogens. Prior infection with bacteriophages T3 or T7, which produce their own deoxyribonucleic acid ligases, can also partially overcome the lethality of gene 30 mutations.


Olfactory control of behavior in rodents.


The effects of Escherichia coli endotoxin in calves.


Self-disclosure: a literature review.

Self-disclosure: a literature review.


Hypothalamic feeding mechanisms and amphetamine anorexia.


The incidence of Babesia divergens infection in a herd of cattle as measured by the indirect immunofluorescent antibody test.


The indirect fluorescent antibody test for the differentiation of infections with Babesia divergens or Babesia major.


Anaphylactic shock to Escherichia coli endotoxin in calves.


Deviant drug use in adolescence: a review of psychosocial correlates.


The post-mortem fixation of farm animals by vascular perfusion.


"Urina est meretrix ...".

"Urina est meretrix ...".


Dermal reactions to endotoxins in calves: their significance in the pathogenesis of colibacillosis.


Effect of para-aminomethylbenzoic acid on the post-irradiation disturbance of haemocoagulation in dogs after whole-body exposure to 600 R.


Studies on the assembly of Newcastle disease virus: an arginine-dependent step in virus replication.


Fast sedimenting deoxyribonucleic acid in bacteriophage T7-infected cells.


Interference with the expression of the N gene function of phage lambda in a mutant of Escherichia coli.


Lambda repressor inactivation in absence of protein synthesis in a ts-DNA mutant of Escherichia coli.


Heteroduplex structures of bacteriophage Mu DNA.


Interstitial gland tissue of mammalian ovary.


The prophylactic treatment of migraine with an antiserotonin pizotifen.


Morphological semi-quantitative scoring of testicular biopsy in infertility.


Treatment of benign essential tremor with propranolol. A controlled clinical trial.


The visual process: Excitatory mechanisms in the primary receptor cells.


Catalytic configurations.

Catalytic configurations.


Monitoring of physiological data in a clinical environment.


Quasi-elastic light scattering from macromolecules.


Interactive computer graphics and representation of complex biological structures.


Conformational analysis of biopolymers: conformational energy calculations.


Effects of radiation on polynucleotides.


Scope, impact, and status of packaged statistical programs.


Neutron scattering.

Neutron scattering.


Uses of fluorescence in biophysics: some recent developments.


Portrait of an institute. The "Ludwig-Aschoff-Haus.


Activation of Rb +  and Na +  uptake into yeast by monovalent cations.


The Cairo Asylum in 1877. From: two visits to the Cairo Asylum, 1877 and 1878. By A. R. Urquhart and W. S. Tuke, J. Mental Sci. 25:43-53, 1879-80.


Strategy and tactics of marijuana research. BEFORE UNDERTAKING MARIJUANA RESEARCH, CERTAIN DEMANDS MUST BE MET IN THE FOLLOWING AREAS: educational and health facilities, the legal position, funding, Food and Drug Directorate regulations and law enforcement. Methodological problems include those concerned with pharmacology, nature of effect, set, setting, subjects, dependent variables and controls. The second portion of this paper describes the methodology and findings of a clinical study of 81 volunteers, selected according to specified criteria, screened psychiatrically and psychologically, then assigned to one of seven experimental groups. Dosage and smoking procedure were standardized for both marijuana and placebo. The experience was evaluated subjectively by the volunteers at the end of each experimental session and again on the following morning.


Flexor compartment syndrome.

Flexor compartment syndrome.


Inhibition of Candida by compounds which inhibit cholesterol biosynthesis. Effects on strains sensitive and resistant to polyenes.


A follow-up study on the cochlear, vestibular and renal function in children treated with gentamicin in the newborn period.


Determination of bacterial resistance to trimethoprim-sulphamethoxazole using the single disc diffusion method.


The vaginal approach to anterior vaginal relaxation.


Discrimination between groups of chromosomes and individual chromosomes in the normal human karyotype.


Reconstruction of urethra and anterior vaginal wall.


The superior vaginal segment-uterine prolapse.


Oculogenital infection with TRIC agents.


Mapping and migration of lymphocyte surface macromolecules.


Synthesis, biochemistry and dynamics of cell surface immunoglobulin on lymphocytes.


Introductory remarks: membrane-polysome interactions.


Mammalian luteinizing hormone-releasing hormone induces ovulation in the domestic fowl.


Purification and properties of dipeptidase M from Escherichia coli B.


Inhibition by aminoacyl transfer ribonucleic acid of elongation factor G-dependent binding of guanosine nucleotide to ribosomes.


Electron microscopic identification of actin associated with isolated amoeba plasma membranes.


Purification and properties of leucyl-tRNA synthetase from Bakers' yeast.


An endonuclease induced by bacteriophage lambda.


Chain initiation factor 2. Purification and properties of two species from Escherichia coli MRE 600.


Feedback regulation in the anthranilate aggregate from wild type and mutant strains of Escherichia coli.


Immunochemical studies of Escherichia coli succinic thiokinase. Effects of sulfhydryl reagents and other treatments on the enzyme.


Cardiovascular classical conditioning in rabbits (Oryctolagus cuniculus) using appetitive or aversive hypothalamic stimulation as the US.


Function of cytidine diphosphate-diglyceride and deoxycytidine diphosphate-diglyceride in the biogenesis of membrane lipids in Escherichia coli.


Blockade and release of hypothalamically and naturally elicited aggressive behaviors in cats following midbrain lesions.


The child with spina bifida: medical and social aspects of the problems of a child with multiple handicaps and his family.


Sugar transport. IV. Isolation and characterization of the lactose phosphotransferase system in Staphylococcus aureus.


Susceptibility of seven common pathogenic bacteria to doxycycline (vibramycin), tetracycline HCI and ampicillin in vitro.


1972 Landis Award presentation to Curt W. Wiederhielm.


Landis Award acceptance. Role of the interstitium in transcapillary fluid exchange.


Microvascular ultrastructure in thermal injury: a reconsideration of the role of mediators.


R factor compatibility groups.

R factor compatibility groups.


Mapping of a complex gene locus coding for part of the Saccharomyces cerevisiae fatty acid synthetase multienzyme complex.


A comparative study of two extended care benefits.


RNA overproducing revertants of an alanyl-tRNA synthetase mutant of Escherichia coli.


Isolation and characterization of 5S RNA-protein complexes from Bacillus stearothermophilus and Escherichia coli ribosomes.


Optimal conditions for the interaction of ribosomal protein S8 and 16S RNA and studies on the reaction mechanism.


Bacteriocin factors responsible for UV-sensitivity and susceptibility to post-irradiation breakdown of DNA.


Location of the ribosomal RNA cistron of Escherichia coli: a second site.


Numerical methods for the detection of abnormalities in radionuclide brain scans.


Biologic behavior of  99m Tc from  99m Tc-pertechnetate ion.


The radionuclide imaging process and factors influencing the choice of an instrument for brain scanning.


Radioisotopic assessment of cerebrospinal fluid pathways.


The blood brain barrier: anatomy and physiology.


Radioisotopic assessment of regional cerebral blood flow.


The normal renogram. B. The normal radiohippuran renogram.


Renal autoradiography.

Renal autoradiography.


Development of the use of radiopharmaceuticals in clinical nephrology.


Radionuclides and renal transplantation.


Measurement of effective renal plasma flow.


Methods for measurement of the renal blood flow.


Measurement of renal function with radioactive materials.


The angiographic appearance of splenic-to-coronary artery anastomosis.


Venous collaterals in a human renal allograft.


Subcutaneous emphysema of the thigh secondary to ruptured diverticulum of the ascending colon.


Intravenous radionuclide cardiography for the detection of cardiovascular shunts.


A comparison of 18 F and 85 Sr scintimetric patterns by computerized data analysis and display.


A new technique for the irradiation of large fields in patients with lymphoma.


An efficacy study of the use of clysodrast in barium enemas.


Alexander Otis Haff, M.D. 1903-1972.

Alexander Otis Haff, M.D. 1903-1972.


William McWhorter Loehr , M.D., 1910-1972.


William Harold Barekman, M.D. 1909-1972.


Pulmonary vascular response to endotoxin in intact dogs.


Prevalence of Trypanosoma cruzi and Trypanosoma rangeli in triatomines (Hemiptera: Reduviidae) collected in the Republic of Panama.


Chronic splenomegaly in Vietnam. I. Evidence for malarial etiology.


Dengue hemorrhagic fever--do we know its cause?


Moderately severe cicatricial entropion.


Kepler's discovery of the retinal image.


Cicatricial ectropion associated with lamellar ichthyosis.


Principles of tissue transplantation as applied to otology.


Ossicular problems.

Ossicular problems.


Intraarticular triamcinolone hexacetonide: double-blind comparison with methylprednisolone.


A combined/oestrogen/progestogen/testosterone agent for the inhibition of lactation.


Kinetics of murine haemopoietic cell proliferation in diffusion chambers.


An estimation of proliferative population size in stomach, jejunum and colon of DBA-2 mice.


A retrospective look at A-V nodal rhythms (A Zahn).


Left ventricular performance after myocardial infarction assessed by radioisotope angiocardiography.


Relationship between pulmonary artery end-diastolic pressure and left ventricular filling pressure in patients in shock.


Order and disorder in the rhythm of the heart. The Fifth Annual George C. Griffith Lecture.


Hemodynamic sequelae of cardiac arrhythmias.


Relation of electrolyte disturbances to cardiac arrhythmias.


Pemphigus foliaceus.

Pemphigus foliaceus.


A study of the effects of certain tranquillizers and small amounts of alcohol on driving performance.


Effects of rostral medial forebrain bundle and olfactory tubercle lesions upon sexual behavior of male rats.


Sensorimotor syndrome produced by lesions of the amygdala and lateral hypothalamus.


Contribution to the microbiology of the mouth by Antony van Leeuwenhoek (24 October 1632--26 August 1732).


Tracheal resection with primary anastomosis in children.


Primary bone involvement in a child with reticulum cell sarcoma.


Three spina bifida defects in one child.


Vertebral anomalies associated with esophageal atresia and tracheoesophageal fistula with reference to the initial operative mortality.


Lobar pulmonary arterial blood flow in reimplanted canine lungs.


Extrusion of pacemaker pulse generator due to design defect.


Serratia marcescens bacteremia originating from a catheter line in the left atrium after mitral valve replacement.


Detection of aspirin sensitivity by pulmonary function tests.


Treatment of acute respiratory emergencies.


Hemifacial atrophy. Unusual cross-lip flap.


Studies on the auto-and the tumor agglutinating activities of proteus vulgaris MC-63.


Aqueous central cavity in aspartate transcarbamylase from Escherichia coli. A three-dimensional x-ray diffraction study of aspartate transcarbamylase to 5.5-angstrom resolution, with the aid of four isomorphous heavy atom derivatives, indicates the presence of a central aqueous cavity approximating an oblate spheroid about 25 by 50 by 50 angstroms in dimension, within a molecule about 90 by 110 by 110 angstroms in largest dimensions.


Studies on the antitumor polysaccharides, especially a mannan preparation derived from Candida utilis--a review.


Protein synthesis by the psychophiles Bacillus psychophilus and Bacillus insolitus.


Lysozymes in yellow fever infection.

Lysozymes in yellow fever infection.


Ultraviolet difference spectra of the lactose repressor protein.


Nitrogen fixation by Klebsiella grown in the presence of oxygen.


Absence of glucokinase in Methanomonas sp. as a cause for their inability to grow on glucose.


The isolation and enumeration of cytophagas.


Photosensitization of Paramecia by aflatoxin.


Microbial ecology of untreated and copper-chrome-arsenic treated stakes exposed in a tropical soil. 1. The initial invaders.


Influence of intrahypothalamie estradiol and hydrocortisone implantation on the pituitary-adrenal and pituitary-ovary functions in the rat.


On the formation of the rifampicin resistant complex of RNA polymerase and DNA.


Prevention of the binding of rifampicin to RNA polymerase.


Effect of proteases on the sigma factor and on its function.


Fluorescence and CD measurements on D-serine dehydratase from E. coli.


Treatment, teaching, research--Veterans Administration Hospital motto: "to care for him who shall have borne the battle".


Cyclamidomycin (desdanine), an inhibitor of nucleoside diphosphokinase of Escherichia coli.


Inhibition of sterol and fatty acid biosyntheses by cerulenin in cell-free systems of yeast.


Virginiamycin: nomenclature.

Virginiamycin: nomenclature.


The effects of dental drill noise on the hearing of dentists.


Pancreatic scanning in the assessment of pancreatic function: experiences with 14 cases of pancreatic steatorrhoea.


Alan Edward McGuinness.

Alan Edward McGuinness.


William Langley Carrington.

William Langley Carrington.


Frederick Claude Florance.

Frederick Claude Florance.


The International Cardiovascular Society.


Anthony Fletcher Howell.

Anthony Fletcher Howell.


Locus of control and attitudes concerning military service.


Studies of the kidneys of mice infected with rodent malaria. II. Characterisation of urinary proteins by micro disc electrophoresis.


The development of sites of metaplastic change in regenerating tendon.


Analysis of skin-test results and case-history data for asthmatic children using a computerized punched-card method.


Solubilization and properties of formate dehydrogenases from the membrane of Escherichia coli.


Objectives of pre-prosthetic surgery.

Objectives of pre-prosthetic surgery.


The activation of renin in human amniotic fluid by proteolytic enzymes.


An adjustable clamp for use during plating and grafting procedures in the mandible.


The management of obesity.

The management of obesity.


Vaginitis: diagnosis and treatment.

Vaginitis: diagnosis and treatment.


Clinical use of psychotherapeutic drugs. I. Antipsychotic and antimanic drugs.


The parallel nature of the interchain disulphide bonds of immunoglobulins. Studies on a mouse IgG1 myeloma protein.


Ribosomal proteins. XLIV. A simple procedure for prefractionation of proteins from Escherichia coli 70S ribosomes and from 30S and 50S subunits.


Helping to meet the dental health care needs of the nation: the potential role of the dental service of the Veterans Administration's health care system. Veterans Administration Advisory Council on Dentistry.


Ethical guidelines for clinical investigation: ethical policy of the American Dental Association regarding the use of human subjects in clinical research. Council on Dental Research.


Attempted induction of tumor antigens in carcinogen-treated cells.


Tumor immunity and the mechanism of polyinosinic-polycytidylic acid inhibition of tumor growth.


Foreign-body tumorigenesis in mice: ultrastructure of the preneoplastic tissue reactions.


Culture of human mammary epithelial cells: keeping abreast with a new method.


Cytotoxicity in vitro by products of specifically stimulated spleen cells: susceptibility of tumor cells and normal cells.


Recombination of human cell lines in rotation culture.


Antibody responses in viral hepatitis, type B.


Unusual renal arteries in a potential kidney donor. Case report.


Review of methods used in lunar organic analysis: extraction and hydrolysis techniques.


Search for biogenic structures and viable organisms in lunar samples: a review.


Distribution and isotopic abundance of biogenic elements in lunar samples.


Compounds of the organogenic elements in Apollo 11 and 12 lunar samples: a review.


Extralunar sources for carbon on the moon.


Diaphragmatic eventration in infants.

Diaphragmatic eventration in infants.


Marrow grafts between histoincompatible canine family members.


Extraterrestrial organic analysis.

Extraterrestrial organic analysis.


Immunofluorescent characterization of the carcinoembryonic antigen in an adenocarcinoma of the small intestine.


Thoracic actinomycosis.

Thoracic actinomycosis.


Levoamphetamine and dextroamphetamine: differential effect on aggression and hyperkinesis in children and dogs.


Sandor Rado 1890-1972.

Sandor Rado 1890-1972.


Precise porcelain jacket crowns.

Precise porcelain jacket crowns.


The first dental anaesthetic in Australia: June, 1847.


Partial purification and properties of UDPG dehydrogenase from Escherichia coli.


Replica models for the scanning electron microscope. A new impression technique.


An assessment of droperidol as a premedicant.


Gentamicin, tubocurarine, lignocaine and neuromuscular blockade. A case report.


Sulfametopyrazine single-dose treatment of urinary tract infections n general practice.


Gram-negative infection complicating portal vein thrombosis.


The use of homografts in keloids.

The use of homografts in keloids.


Combined craniofacial resection for tumour involving the orbital walls.


The late treatment of enophthalmos: a case report.


Delaying of flaps. A useful adjunct.

Delaying of flaps. A useful adjunct.


Composite grafts of skin and fat.

Composite grafts of skin and fat.


Treatment of severe decubitus ulcers using the Beaufort-Winchester water bed.


Cavernous haemangioma of nasal bone.

Cavernous haemangioma of nasal bone.


Viruses of vomiting.

Viruses of vomiting.


Gastroenteritis of infancy.

Gastroenteritis of infancy.


Some diseases characteristic of modern Western civilization.


Antibiotic sensitivity of Escherichia coli.


A review of anticoagulant rodenticides in current use.


Growth of microorganisms in two-dimensional steady-state diffusion gradients.


The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis.


The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse.


The formaldehyde stability of thymocyte immunogens.


The use of freeze-preserved treponemes in the Treponema pallidum immobilization test.


Modulation of the immune response by a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). II. Relationship of antigen dose to heightened primary and secondary immune responses to sheep red blood cells.


Perfusion of rabbit kidneys with cryoprotective agents.


Renal preservation by hypothermic perfusion using a defined perfusion fluid.


Growth and DNA synthesis in embryonic chick heart cells, in vivo and in vitro.


Intracellular freezing in biomaterials.

Intracellular freezing in biomaterials.


Proof that certain RNAs shuttle non-randomly between cytoplasm and nucleus.


Quantitative micro-assay for RNA-DNA hybrids in the study of nucleolar RNA from Chironomus tentans salivary gland cells.


Leucoplast of the cryptomonad Chilomonas paramecium. Evidence for presence of a true plastid in a colorless flagellate.


Families of replicating units in cultured hamster fibroblasts.


Cellular senescence and DNA synthesis. Thymidine incorporation as a measure of population age in human diploid cells.


Selective solubilization of mammalian spermatozoa structures.


Stimulation of HeLa cell-surface attachment by histones.


Photo-reconstituted collagen gel for tissue culture substrates.


Myosin-like protein in Physarum nuclei.

Myosin-like protein in Physarum nuclei.


Public health and politics in China's past two decades.


Immunity to Escherichia coli in pigs: IgG immunoglobulin in passive immunity to E. coli enteritis.


Sibling influence on sex-role preference of young children.


Effectf of synthetic luteinizing hormone-releasing hormone (LH-RH) in two brothers with hypogonadotropic hypogonadism and anosmia.


The early response of immunocompetent cells as analyzed by velocity sedimentation separation.


The effect of a streptococcus pyogenes teichoic acid on the immune response of mice.


Purification and characterization of coliphage MS2 hapten conjugates.


Totipotency and embryogenesis in plant cell and tissue cultures.


Fibrillar assemblage of variable segments of immunoglobulin light chains: an electron microscopic study.


Antibody-binding characteristics at the cellular level. I. Comparative maturation of hapten-specific IgM and IgG plaque-forming cell populations.


Antigenic properties of rabies virus components.


Predominance of theta-positive lymphocytes in gut-associated and peripheral lymphoid tissues of newborn mice.


Specific purification of lymphocyte populations on a digestible immunoabsorbent.


Neuronal nets and nerve cell interactions in vitro in insect systems.


Rat myocardial cells in vitro: mitosis and differentiated properties.


The role of humoral factors in the initiation of in vitro primary immune responses. II. Effects of lymphocyte mitogens.


Occupational health and the APHA.

Occupational health and the APHA.


Quantitative cerebral circulation studies with sodium pertechnetate.


A multiple image subtraction technique for enhancing low contrast, periodic objects.


Replication and differentiation in vitro of epidermal cells from normal human skin and from benign (psoriasis) and malignant (basal cell cancer) hyperplasia.


Magnetic resonance studies on membrane and model membrane systems. II. Phosphorus spectra and relaxation rates in dispersions of lecithin.


Regulation of polar cap formation in the life cycle of Escherichia coli.


Derepressed leucine transport activity in Escherichia coli.


Association of newly synthesized major f1 coat protein with infected host cell inner membrane.


A wedding at Maer.

A wedding at Maer.


Infra red microscopy.

Infra red microscopy.


Health care delivery systems of the Tennessee Valley Authority.


Computer-assisted clinical decision-making.


Thymidylate synthetase in mouse erythrocytes infected with Plasmodium berghei.


The inhibition of ribonucleic acid polymerase from Escherichia coli by 6-chloro-8-aza-9-cyclopentylpurine.


Small subcutaneous doses of heparin in prevention of venous thrombosis.


Removal of plutonium from mouse liver by glucan and DTPA.


Ultraviolet-induced delay of budding in synchronized yeast cells.


Farrington Daniels 1889-1972.

Farrington Daniels 1889-1972.


The fever index: a quantitative indirect measure of hospital-acquired infections in obstetrics and gynecology.


Trophoblastic origin of the X cell and the placental site giant cell.


Giant chorioangioma.

Giant chorioangioma.


Angionephrotomography and subtraction. Relative value in renal mass lesions.


The importance of subtraction in the angiographic evaluation of extraadrenal pheochromocytomas.


Clinical courses of Hodgkin's disease and other malignant lymphomas.


Stage I and II non-Hodgkin's lymphoma. Results of regional radiation therapy.


Lymphosarcoma in children. A roentgenologic and clinical evaluation of 60 children.


Neonatal calf diarrhea: propagation, attenuation, and characteristics of a coronavirus-like agent.


Nature of thrombus in a hollow fiber oxygenator.


Proliferative ileitis of hamsters: electron microscopy of bacteria in cells.


Detection of hepatitis B antigen by counter-immunoelectrophoresis: enhancing role of homologous serum diluents. Dilution of hyperimmune hepatitis type B antibody in undiluted homologous species normal serum has resulted in enhanced sensitivity for detecting hepatitis B antigen by a discontinuous counter-immunoelectrophoresis method compared to hepatitis type B antibody diluted in heterologous species normal serum or buffer solutions.


Bacteriophage typing of clinically isolated Serratia marcescens. A bacteriophage-typing scheme for the differentiation and classification of clinically isolated strains of Serratia marcescens was developed. Thirty-four Serratia bacteriophages were isolated from sewage and used to type 185 of 204 isolates (90.6%) of S. marcescens into 23 bacteriophage groups representing 71 types. Different bacteriophage types occurred at different intervals, suggesting that particular strains of S. marcescens are found at certain times. A correlation was found between inositol fermentation and bacteriophage type and between susceptibility to carbenicillin and bacteriophage type. However, there was no relationship between source of isolate and bacteriophage type. Bacteriophage typing of S. marcescens should provide a system which will aid in determining the origin of nosocomial Serratia infections.


Anticapsin, a new biologically active metabolite: screening and assay procedures. In addition to its implication in the virulence of Streptococcus pyogenes, the hyaluronic acid capsule produced by this bacterium renders it resistant to infection by bacteriophage. A method employing S. pyogenes and a bacteriophage incorporated into an agar plate was devised as a screen to detect compounds that inhibit the formation of the hyaluronic acid capsule. Filter-paper discs saturated with experimental compounds were applied to the surface of test plates containing host plus phage and control plates of host only. After incubation, inhibition of capsule synthesis was indicated by the presence of clear zones where phage infection and lysis had occurred. Zones of growth inhibition on control plates represented classical antibacterial activity. During the testing of over 6,000 fermentation samples, anticapsin, a unique metabolite, was discovered. Modification of incubation temperature, thickness of agar layers, and host-phage input ratios resulted in a quantitative assay method having a dose-response range of 4 to 160 mug of anticapsin.


Endocrine problems in otolaryngology.

Endocrine problems in otolaryngology.


Biodegradation of ethylene glycol by a salt-requiring bacterium. A gram-negative nonmotile rod which was capable of using 1,2-(14)C-ethylene glycol as a sole carbon source for growth was isolated from a brine pond, Great Salt Lake, Utah. The bacterium (ATCC 27042) required at least 0.85% NaCl for growth and, although the chloride ion was replaceable by sulfate ion, the sodium ion was not replaceable by potassium ion. The maximal concentration of salt tolerated for growth was approximately 12%. The bacterium was oxidase-negative when N,N-dimethyl-p-phenylenediamine was used and weakly positive when N,N,N',N'-tetramethyl-p-phenylenediamine was used. It grows on many sugars but does not ferment them, it does not have an exogenous vitamin requirement, and it possesses a guanine plus cytosine ratio of 64.3%. Incorporation of ethylene glycol carbon into cell and respired CO(2) was quantitated by use of radioactive ethylene glycol and a force-aerated fermentor. Glucose suppressed ethylene glycol metabolism. Cells grown on ethylene and propylene glycol respired ethylene glycol in a Warburg respirometer more rapidly than cells grown on glucose. Spectrophotometric evidence was obtained for oxidation of glycolate to glyoxylate by a dialyzed cell extract.


Klebsiella biotypes among coliforms isolated from forest environments and farm produce. Samples of water, soil, needles, and bark were collected from three different forest environments and from a pulp and paper mill. In addition, samples of fresh produce were obtained from a local supermarket. All samples were examined for total and fecal coliforms. The counts obtained from the forestrelated samples did not correlate with sample type or location. When 123 isolates were identified biochemically, 71% were Klebsiella, 19% Enterobacter, 8% Citrobacter, and 2% Escherichia. All the Citrobacter, 75% of the Enterobacter, and 65% of the Klebsiella were negative for growth in elevated coliform (EC) broth. All the Escherichia were EC positive. The counts obtained from the fresh produce were generally higher than the forest counts, but the distribution of biotypes was similar. Of the 146 isolates examined 64% were Klebsiella, 14% were Escherichia, 14% were Enterobacter, and 8% were Citrobacter. All the Enterobacter and Citrobacter were EC negative, whereas 25% of the Klebesiella and 80% of the Escherichia were EC positive.


Bacteriological survey of the blue crab industry. During sanitation inspections of 46 crabmeat processing plants on the Atlantic and Gulf Coasts, 487 samples of whole crabs immediately after cooking, cooked crabs after cooling, backed or washed (or both) crab bodies and whole crab claws, as well as 1,506 retail units of finished product were collected and analyzed bacteriologically. The 1,506 retail units (1-lb [373.24-g] cans) included 518 cans of regular (special) meat, 487 cans of claw meat, and 501 cans of lump meat. Statistical analyses showed that crabmeat from plants in Mississippi, Louisiana, and Texas had higher counts in 19 of 24 cases for the four bacteriological indices than crabmeat from plants located along the Atlantic Coast and the Gulf Coast of Florida. Aerobic plate counts of retail units collected from a previous day's production were significantly higher than those collected on the day of inspection. Regular crabmeat had consistently higher aerobic plate counts than claw or lump meat. When the product was handled expeditiously under good sanitary conditions, the bacteriological results were significantly better than the results from plants operating under poor sanitary conditions. Crabmeat produced in plants operating under good sanitary conditions had the following bacteriological content: (i) coliform organisms average most-probable-number values (geometric) of less than 20 per g; (ii) no Escherichia coli; (iii) coagulase-positive staphylococci average most-probable-number values (geometric) of less than 30 per g in 93% of the plants; (iv) aerobic plate count average values (geometric) of less than 100,000 per g in 93% of the plants, with the counts from 85% of these plants below 50,000 per g.


Induction of protoplasts of Schizosaccharomyces octosporus in a defined medium. Protoplasts of Schizosaccharomyces octosporus were formed in a defined medium consisting of yeast nitrogen base, adenine, glucose, MgSO(4), and 2-deoxy-D-glucose.


Lipid content of antibiotic-resistant and -sensitive strains of Serratia marcescens. The lipid content of antibiotic-resistant, nonpigmented strain (Bizio) and antibiotic-sensitive, pigmented strain (08) of Serratia marcescens was studied. The resistant strain contains at least three times more total extractable lipid and phospholipid than the sensitive strain. Lysophosphatidylethanolamine, phosphatidylserine, lecithin, phosphatidylglycerol, phosphatidylethanolamine, and polyglycerolphosphatide were identified in the phospholipid fractions of both strains.


On the accumulation of short peptides in the presence of certain inhibitors of protein synthesis.


Mechanism of allylisopropylacetamide-induced increase of  -aminolevulinate synthetase in liver mitochondria. VI. Multiple molecular forms of  -aminolevulinate synthetase in the cytosol and mitochondria of induced cock liver.


Purification and properties of an enzyme, zymolyase, which lyses viable yeast cells.


Darier's disease. An electron microscopic study.


The role of ferric enterochelin esterase in enterochelin-mediated iron transport and ferrochelatase activity in Escherichia coli.


Steroids in treatment of pertussis. A controlled clinical trial.


Topical vitamin A acid in the treatment of psoriasis.


Fertility and psychiatric morbidity.

Fertility and psychiatric morbidity.


Alkaloid inhibition of yeast respiration--prevention by Ca 2+ .


Viral infection and renal transplant rejection.


The influence of long-term IUD use on vaginal smears.


Physiology and chemistry of the hypothalamic releasing factors for gonadotropins: a new approach to fertility control. A short review of research in hypothalmic releasing factors emphasizes their isolation, characteristics, and molecular structure and their application to fertility control.  The hypothalamus regulation of the pituitary's gonadotropic secretion has been identified as taking place in a special type of capillary vessel which unites the area of median eminence of the hypothalamus to the anterior lobe of the  pituitary.  This hypophysiotropic area secretes the hypothalamic hormones (LH, FSH, etc.) that are small polypeptides with two important characteristics: 1) extremely powerful effect in miniscule doses, and 2) extreme specificity of action.  The latter is particularly important in contrast to steroids (estrogen, progesterone, etc.) presently used, whose generalized effects cause side reactions in oral administration.  Use of these highly specific hypothalamic hormones could be completely free of side effects.  The LH-releasing factor has been synthesized, and research indicates use of this hormone as a means of restoring fertility through its effect on LH and FSH production.  Fertility control is indicated by either using the LH-releasing factor to precisely date the time of ovulation, providing accuracy to the rhythm method, or through development of a synthetic LRF antagonist to prevent fertility by inhibiting  the LH-releasing factor.  This could be done orally with a pill taken only once per month.  Further research is continuing.


Preliminary observations on the effects of copper, zinc and polyethylene I. U. F. Bs. on the uterine motility of the rabbit.


Ultrastructure of mouse uterine epithelium influenced by fluid from an IUD-containing horn.


The antiimplantation effect of the polyethylene IUD in the rat.


The first year of clinical experience with the copper T intrauterine contraceptive system in the United States and Canada.


The Silicone Shell IUD.

The Silicone Shell IUD.


Studies on development of a vaginal preparation providing both prophylaxis against venereal disease, other genital infections and contraception. 3. In vitro effect of vaginal contraceptive and selected vaginal preparations of Candida albicans and Trichomonas vaginalis. 41 preparations (jellies, creams, foams, etc.) were tested each in several dilutions with physiological saline for effect on inhibition of growth of C. albicans and T. vaginalis.  21 contraceptives and 20 noncontraceptives were employed.  In both types of cultures, 1 method used to study growth involved mixing of preparation and organisms and intervals of 1, 5, or 10 minutes before inoculation of the medium, while the other method involved inoculation after the prepartion was  added to the medium.  These method types are referred to in the study as time exposure and dilution.  Evaluation was 48 hours after start of incubation.  The contraceptives effective (no growth) at some concentration from 10%-50% against C. albicans by the time-exposure method were the same contraceptives effective by the dilution method.  They were Certane vaginal jelly, Lorophyn jelly, Contra foam, Lorophyn suppositories, Koromex A vaginal jelly, and Lanesta gel.  Certane vaginal jelly was effective after exposure (interval after mixing and before inoculation) for 1 minute.  Among the noncontraceptive preparations 10 were effective by the time-exposure method and an additional 4 were effective by the dilution method. In an associated test C. albicans was uninhibited by exposure up to 10 minutes in a pH of 2.2-10,  thus casting out the possibility that the preparations are effective through pH.  By the time exposure method all contraceptives were effective against T. vaginalis, most at a 1% concentration.  All except 2 noncontraceptives were effective by both methods.  The use of some of these preparations, contraceptive and noncontraceptive, might reduce the female's risk of contracting either infection during intercourse.


Clinical experience with the Cu-7 intrauterine device. 186 women ranging in age from 18-40 years were selected from the Los angeles Planned Parenthood Clinic and used the Cu-7 intrauterine device for 1693 woman-months.  110 of these women had never been pregnant or had aborted their only pregnancy.  There were 1.1 pregnancies/100 women for the first year of use, calculated by the life-table method.  7 women expelled the Cu-7 device during the first year of the study, while 20 other women had it removed for medical reasons, 18 of these for excessive bleeding and/or cramping.  The device was effective and well tolerated.


Intrauterine contraception with the copper-T device. 3. Effect upon endometrial morphology. Endometrial morphology was investigated before, during, and after 12 cycles of use of the Cu-T intrauterine device in 20 22-36 year old women with regular menstrual cycles.  Endometrial biopsies were obtained during the proliferative phase, on Cycle Days 10, 11, or 12 of 1 menstrual cycle, and during the secretory phase on Days 20, 21, 22, or 23 of t,e next cycle prior to the insertion of the Cu-T device.  Biopsies were also taken on several occasions on the same cycle days during Year 1 with the device in utero and also during the first 2 cycles following removal of the device.  The development of both the proliferative and secretory endometrium in the presence of the device did not differ from the time prior to insertion to the time of removal of the device.  During usage of the Cu-T there was a gradual increase in the number of endometrial specimens showing groups of leukocytes in the glandular lumina.  These leukocytes, which may be of importance to the Cu-T antifertility effect, were mostly neutrophils.  Lymphocytes and macrophages were present to a limited extent.  In contrast to other IUDs such as the loop, few inflammatory cells were found in the stroma of women using the Cu-T.  Ovarian hormone production was not impaired by the use of the Cu-T, as biopsies and basal body temperature failed to show any impairments.


Intrauterine contraception with the copper-T device. 4. Influence on protein and copper concentrations and enzyme activities in uterine washings. The concentrations of protein and copper and the activities of acid and alkaline phosphatase and beta-glucuronidase were measured in the uterine fluid of 8 25-38 year old women using the copper-T (Cu-T) 200 device for intrauterine  contraception.  Specimens were obtained in the proliferative phase on Cycle Days 10-12 of 1 menstrual cycle, and in the secretory phase on Days 20-23 during the next cycle prior to the insertion of the Cu-T, and during the same cycle days in Cycles 2 or 3 or  6 or 7 following insertion.  Uterine fluid was obtained by irrigating the uterine cavity with physiological saline, while endometrial biopsies were taken for histological dating of the endometrium.  The protein concentration of the uterine washings did not change significantly as a result of the Cu-T insertion.  There was a significant difference (p.001) in Cycles 2 or 3 and 6 or 7 following insertion.  Acid phosphatase activity was not influenced by the presence of the device.  The betaglucuronidase in the fluid obtained during the proliferative phase showed a significant increase (p  .001) DURING THE TIME WHEN the device was situ.  The device caused a significant increase in the copper concentration in both phases, while the copper level in the blood serum remained unchanged.  There was as increased number of white blood cells in the washings obtained during the secretory phase.  The increase in the copper concentration of the uterine fluid might be the cause of the Cu-T antifertility effect due to a spermatotoxic and/or blastotoxic effect, as may the enzymic changes and increase of white blood cells.


Abortion: patterns, technics, and results.


Education and the hospital: counseling as preventive medicine.


Medical staffs merge.

Medical staffs merge.


Tranquilizers and examination stress.

Tranquilizers and examination stress.


Separation of human lymphoid cells into G 1 , S, and G 2  cell cycle populations by use of a velocity sedimentation technique. Human lymphoid tissue culture cells can be separated according to cell size and corresponding cell cycle phase with a velocity sedimentation centrifugation method employing a continuous 5-20% wt/wt Ficoll gradient. A 7-fold increase in streaming limit was achieved by placing a buffer zone of isosmolar 5% Ficoll on top of the gradient before application of the cell load. The various pooled populations of cells from upper, middle, and lower areas of the gradient were characterized using autoradiographic, TCA-precipitable (3)H]thymidine incorporation, and Fuelgen microspectrophotometric methods. The upper range of the gradient contains cells in the G(1) cell cycle phase; the lower range, cells in the G(2) phase; cells found in the middle of the gradient belong largely to the S phase of the cell cycle. These gradient-separated cell pools contained relatively little contamination with cells from other phases of the cell cycle and, when explanted from the gradient into fresh growth media, showed growth patterns characteristic of synchronized cell populations. This system of cell separation provides a useful tool for investigating the relationship of the cell cycle to surface membrane and metabolic characteristics in human lymphoid cell culture systems.


Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age.


Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. Polymorphonuclear leukocyte (PMN) locomotion and chemotaxis have been evaluated by direct microscopic observation of individual cells in thin slide-cover slip preparations, and also by observations on populations of cells migrating into a Millipore filter. The direct microscopic method used the polarity of the locomoting PMNs (broad, advancing lamellipodium and knoblike constriction at the rear) to record the direction of movement. The Boyden chamber Millipore assay was made more reliable by following the front of cells advancing into the filter, rather than counting the number of cells on the lower filter surface. Special modifications of the Millipore assay were necessary in order to distinguish between influences on rate of locomotion and true chemotaxis. In both systems the results indicate that under certain conditions leukocytes, and in particular PMNs, release into the medium a factor stimulating locomotion and exerting chemotactic action on PMNs in the vicinity. This cell-derived factor appears not to require serum factors for its release or action.


Studies on serum   1 C in Thai children and fibrin degradation product associated with acute poststreptococcal.


Stimulation of IgG antibody response in vitro by T cell-replacing factor. A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.


Cancer of the hypopharynx.

Cancer of the hypopharynx.


The role of bilateral nephrectomy in the treatment of hypertension of chronic renal failure.


Experimental pyelonephritis in dogs. I. Confirmation by antibody response.


Fine-needle aspiration biopsy in the diagnosis of human renal allograft rejection.


Hexamethylmelamine (NSC-13875) for acute leukemia and solid tumors in children.


Urological complications of renal transplantation.


Immunologic aspects of interstitial cystitis.


Anterior urethral strictures: experience with free graft urethroplasty.


The Royal Academy of Medicine in Ireland: fellows, members and honorary fellows.


Role of mid-urethral high pressure zone in spontaneous bacterial ascent.


Clorazepate dipotassium: a new benzodiazepine antianxiety agent.


Functional considerations of urethral sphincteric dynamics.


Prevention of failure in vasectomy.

Prevention of failure in vasectomy.


Short-term intense surveillance of adverse drug reactions.


Symptomatic volunteers: another patient dimension for clinical trials.


A double-blind comparison of haloperidol oral concentrate, haloperidol solutabs and placebo in the treatment of chronic schizophrenia.


Rabbit renal autografts as an organ preservation model.


Glomerulonephritis: a classification based on morphology with comments on the significance of vessel lesions.


Cyclobenzaprine in the treatment of chronic tension headache.


Daniel Gerard Lane.

Daniel Gerard Lane.


The GH and AS hypertensive rat strains.

The GH and AS hypertensive rat strains.


Augmenting the action of levodopa.

Augmenting the action of levodopa.


Fine structure and function of the abdominal chloride epithelia in caddisfly larvae.


The indirect fluorescent antibody technique as a method for detecting serum antibodies against hog cholera. II. Its further evaluation by a comparative assay with three other serological tests.


Long-term hemodialysis in the neonatal period.


A current review of brain abscess.

A current review of brain abscess.


Toxoplasmosis as a cause of hydranencephaly.


Edward Leland Jenkinson, M.D., 1892-1972.


Starch granulomatous peritonitis.

Starch granulomatous peritonitis.


Kenneth Edward Hodge, D.M.R.D., 1921-1972.


Lymphosarcoma of the colon.

Lymphosarcoma of the colon.


Open skin-grafting in developing countries.


Arterial peaks in regional cerebral blood flow  133 Xenon clearance curves.


Myxedema coma.

Myxedema coma.


Studies on 2-(3-benzoylphenyl) propionic acid (Orudis). A double-blind cross-over trial in patients with rheumatoid arthritis and an assessment of its influence on hepatic drug-metabolizing enzymes.


Computer-assisted statistical analysis of skeletal scintigrams.


Shortage of cadaver kidneys.

Shortage of cadaver kidneys.


Secondary fluorescent staining of virus antigens by rheumatoid factor and fluorescein-conjugated anti-IgM.


Carcinoma involving the lower alveolus. An appraisal of past results and an account of current management.


Electrophysiological studies in the denervated transplanted human heart. Response to trial pacing and atropine.


Double-blind trial of carbenoxolone sodium capsules in duodenal ulcer therapy, based on endoscopic diagnosis and follow-up. A high-dose double-blind trial of carbenoxolone sodium capsules (Duogastrone) in the treatment of duodenal ulceration was combined with endoscopic diagnosis and follow-up. Thirty-one ambulant patients with an endoscopically visible duodenal ulcer were allocated at random to a 12-week course of treatment with either carbenoxolone sodium 300 mg daily or a placebo. Symptomatic and endoscopic follow-up was performed at 2-4 weeks, 6-8 weeks, and 12-16 weeks. Carbenoxolone was shown to increase the rate of healing of duodenal ulcers in the early stages of treatment, but by 12 weeks there was no difference between the two groups. There was no significant difference in symptomatic improvement between the two groups at any stage of treatment. Side effects, especially hypokalaemia, were prominent in the patients treated with carbenoxolone. There was a poor relation between endoscopic and symptomatic improvement in patients on either form of treatment.


Uncomplicated male gonorrhea--a review.

Uncomplicated male gonorrhea--a review.


Pseudo-achondrogenesis with fractures.

Pseudo-achondrogenesis with fractures.


Glucose and insulin metabolism after pancreatic transplantation. After removal of the pancreas pigs develop hyperglycaemia and ketosis. Both orthotopic and heterotopic transplants prevent hyperglycaemia but the animals so treated display markedly different patterns of glucose and insulin metabolism. Orthotopic graft recipients have normal glucose tolerance curves with raised plasma insulin levels. The glucose tolerance curves of heterotopic graft recipients show significant hypoglycaemia and very marked hyperinsulinaemia. These results are explicable by the diversion of the two pancreatic hormones from the liver, and possibly by the effect of ischaemia and denervation on the pancreas.


In memoriam: Dr. J.B. Chatterjea.

In memoriam: Dr. J.B. Chatterjea.


Development of diploma in public health in India.


Dr. K.C. Patnaik.

Dr. K.C. Patnaik.


Growth studies in India: an appraisal of studies conducted in last 50 years. II. Birth to 5 years.


Paranoia or persecution: the case of Schreber.


The Schreber case sixty years later.

The Schreber case sixty years later.


The case of Schreber. Commentary.

The case of Schreber. Commentary.


Child rearing practices and Hindu personality formation.


Heats of activation for the exosmotic flow of water across the membrane of leucocytes and leukemic cells.


Serum dependent growth of primary cultured differentiated fetal rat hepatocytes in arginine-deficient medium.


Contact inhibition of what? An analytical review.


Azaguanine resistant hamster cell lines not deficient in hypoxanthine-guanine phosphoribosyl transferase.


The Austrian sanitary cordon and the control of the Bubonic plague: 1710-1871.


The Galenic works cited in Guy de Chauliac's Chirurgia magna.


Religion and medicine: the Chinese opium problem.


Measles: a potentially finite history.

Measles: a potentially finite history.


The changing scene. Forty years of medicine.


Illustration of betel (areca) nut chewing in Sawankalok celadon figurines from Thailand.


Tobit recovering his sight. Engraving by A. de Marcenay after Rembrandt.


A hypothesis as to the mechanism of fulminant course and death in the sweating sickness.


The role of sports in rehabilitation of the handicapped. 1A. Historical.


Studies on hemorrhagic fever in Thailand 1958-1971: a review.


A review of some newer ideas in burn wound management with emphasis on the use of a burn unit.


Pyrogen fever and prostaglandin-like activity in cerebrospinal fluid. 1. In the unanaesthetized cat, rectal temperature was recorded and c.s.f. was collected from a Collison cannula implanted into the third ventricle with its opening lying in close proximity to the anterior hypothalamus. Samples of c.s.f. were collected from the same cat, during normal temperature, during fever produced by Shigella dysenteriae injected into the third ventricle and during the fall in temperature which occurred when the antipyretic paracetamol was injected intraperitoneally during the pyrogen fever.2. The samples of c.s.f., when tested on the rat stomach fundus preparation, caused contractions which were not due, or at most to a small degree only, to 5-hydroxytryptamine, as they were resistant to BOL. They were therefore probably due to a prostaglandin-like substance.3. When assayed against PGE(1), the activity of c.s.f. collected from cats when their body temperature was normal corresponded to between 1.3 and 10 ng/ml. The values, whether low or high, rose over 2.5-4 times to between 4 and 35 ng/ml. in c.s.f. collected during pyrogen fever; they were again low, between 1.5 and 6 ng/ml., in samples collected when the fever had been brought down by paracetamol, but rose again with the return of fever.4. The results provide direct evidence for the theory that fever produced by pyrogens results from their ability to increase synthesis and release of prostaglandins, and that antipyretics bring down the fever because they inhibit the increased synthesis.


Iatrogenic immunotherapy of lung cancer.


Medical management of primary hypertension. 2.


Mapping of behaviour in Drosophila mosaics.


Controlled clinical trials and the FDA.

Controlled clinical trials and the FDA.


Problems with di-iodohydroxyquin.

Problems with di-iodohydroxyquin.


Biochemical evidence for the bidirectional replication of DNA in Escherichia coli.


Locating protein in membranes.

Locating protein in membranes.


Lymphocytes, hormones and ageing.

Lymphocytes, hormones and ageing.


Efficient recognition of pictures in organic amnesia.


The suppression of non-specific esterase activity in mouse skin sebaceous gland by "CS" gas.


Relationship between the concentration of caesium-137 in milk and man.


Newborn size and pelvic dimensions of Australopithecus.


Avery in retrospect.

Avery in retrospect.


Graeme Ballantyne Smaill.

Graeme Ballantyne Smaill.


Edward Cecil Brewis.

Edward Cecil Brewis.


Heat studies in excitable tissues.

Heat studies in excitable tissues.


Vagal sensory receptors and their reflex effects.


Interrelationships of mammalian hormones and enzyme levels in vivo.


Evaluation of acute blood loss by means of simple hemodynamic parameters.


Present state of coronary artery surgery.


Operative treatment of varicose veins.

Operative treatment of varicose veins.


The abrogation of immunological tolerance by means of allogeneic confrontation.


Fluorescein-labelled antibody for the diagnosis of foot-rot.


Foreign bodies in the tracheobronchial tree: (report of a foreign body removed successfully by endoscopy six years following aspiration).


Specific oral prevention of infantile enteritis. 3. Experiments with corpuscular vaccine.


Action potential and contraction of heart muscle.


Atrioventricular and intraventricular conduction. Revised nomenclature and concepts.


Quantitation of experimental aortic regurgitation by roentgen videodensitometry.


Thomas Jowett on pericardiocentesis (1827).


Timely topics in microbiology miscellaneous bacteria.


Detection of indole produced by bacteria on blood agar plates.


Gastric acid and pepsin secretory response in dogs to an analog of gastrin.


Evaluation of a new surgical suture (prolene).


Georg von Békésy, 1899-1972.

Georg von Békésy, 1899-1972.


Experiences with residual and recurrent cholesteatoma.


Surgical problems in amoebiasis.

Surgical problems in amoebiasis.


A cholesteatoma chronicle.

A cholesteatoma chronicle.


Care of the eye in facial paralysis.

Care of the eye in facial paralysis.


Humoral and cell mediated responses in vitro of spleen cells from mice with thymic aplasia (nude mice).


A total mortality survey of nine batches of broiler chickens.


Diagnosis of Babesia argentina infection in cattle using brain smears.


Recent knowledge of the strict anaerobes of the gut.


Effect of carcinogens on DNA. Action of 7-bromomethylbenz (a) anthracene.


Partial localization of the 5S RNA binding site on 23S RNA.


Preparation and maintenance of living house cricket (Acheta domesticus) spermatocytes.


The presence of tumour-specific membrane antigen in the serum of rats with chemically induced sarcomata. Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect membrane immunofluorescence and mixed haemadsorption with a (51)Cr-labelled indicator cell. After tumour excision, anti-TSTA antibody was readily measurable in both serum and lymph. In contrast, the tumour-bearing animal had no measurable anti-TSTA antibody in the serum but low titres in the lymph. Consequently, we formed the hypothesis that in the presence of a growing tumour the serum contained antigen-antibody complexes with antigen in excess.To test this hypothesis, tumour-bearing serum was examined for the presence of free antigen and antigen-antibody complexes by 2 different methods. In the first method, tumour-bearing serum was cross-linked with glutaraldehyde and was found to absorb specifically the anti-TSTA antibody, indicating free circulating TSTA. Next, antigen-antibody complexes were split with salt or acid and separated into a low molecular weight (or "antigen") fraction (<100,000) and a high molecular weight (or "antibody") fraction (>100,000). The low M.W. fraction specifically inhibited the anti-TSTA antibody when tested by either membrane immunofluorescence or mixed haemadsorption, indicating the presence of antigen from antigen-antibody complexes in the tumour-bearing circulation. The possible effect on the host's immune response of circulating free tumour antigen and antigen-antibody complexes are discussed.


Chlamydial infection. Improved methods of collection of material for culture from the urogenital tract and rectum.


Chlamydial infection. Incidence in 'non-specific' urethritis.


Chlamydial infection. Isolation of Chlamydia from patients with non-specific genital infection.


Chlamydial infection. Results of micro-immunofluorescence tests for the detection of type-specific antibody in certain chlamydial infections.


IgM class antitreponemal antibody in treated and untreated syphilis.


Neonatal congenital syphilis. Diagnosis by the absorbed fluorescent treponemal antibody (IgM) test.