Multiple myeloma: development of plasma cell sarcoma during apparently successful chemotherapy. Three patients with multiple myeloma who developed a plasma cell sarcoma during apparently successful chemothapy are described. It is postulated that the chemotherapy induced the sarcomatous change.


Home health care--untapped potential.

Home health care--untapped potential.


Mesangial cells in membranous glomerulonephritis. Renal biopsies of seven patients with membranous glomerulonephritis were examined by light, electron, and immunofluorescence microscopy. All had characteristic changes of glomerular basement membranes, typically with bright granular membranous fluorescence of IgG and variable deposits of complement. Cellularity was normal or slightly increased due largely to mesangial cell proliferation. These cells assumed a variety of appearances referred to as resting, hyperactive, and dark. Resting forms occurred in cases with normal cellularity and limited complement deposition. Hyperactive cells showed ultrastructural evidence of increased secretory and digestive activity and were associated with proliferation and more pronounced complement deposition. Dark cells, interpreted as undergoing shrinkage and degeneration, were found in small numbers in all biopsies.


Recurrent haematuria and mesangial IgA deposition. Six patients are described in whom recurrent haematuria was associated with IgA deposits in the glomerular mesangium. These patients conform closely to the nephropathy described by Berger. The condition can only be definitely diagnosed by immunofluorescence techniques. These six patients were diagnosed in one renal unit within 18 months and, despite the absence of reports from British units, this nephropathy is probably not uncommon. No treatment for it is known at present but the prognosis appears to be good in most patients. Renal failure and hypertension have been reported and long-term follow up is necessary to clarify the natural history of the disease.


The use and abuse of the psychotropic drugs.


Editorial: In appreciation: Delbert Oberteuffer, Ph.D. professor emeritus, the Ohio State University.


The changing focus in health delivery.

The changing focus in health delivery.


Rehabilitation: the evolution of a social concept.


On the site of the microbiological reduction of cholesterol to coprostanol in the rat.


Malaria in New York City. 3. 1940 to 1959.


Yellow fever epidemic in Philadelphia, 1793. Physicians in dispute.


The reproductive adolescent.

The reproductive adolescent.


Venereal disease in adolescents.

Venereal disease in adolescents.


Teenage obesity.

Teenage obesity.


The adolescent athlete.

The adolescent athlete.


Seizures.

Seizures.


The outlook for adolescents with chronic renal failure.


The rheumatic diseases in adolescence.

The rheumatic diseases in adolescence.


Health care for the economically disadvantaged adolescent.


Tragic magic: word usage among New York City heroin addicts.


The radiosensitive stages of the rat incisor odontoblast as demonstrated by autoradiography.


Hysteria and hysterical personality: how come one without the other?


Antibodies to Escherichia coli in alcoholic and non-alcoholic patients with cirrhosis of the liver or fatty liver.


Some concepts on ammonia, porta-systemic shunts, and encephalopathy.


The influence of varying pressure and duration of treatment with hyperbaric oxygen on the survival of skin flaps. An experimental study.


Photoelectric oscillometry. I. Physiological and technical study factors in the measurement of skin circulation.


Freeze drying of skin. In vitro studies of vitality.


BHm: a weak B antigen variant.

BHm: a weak B antigen variant.


The psychotropic effect of a single dose of oxyprothepin and octoclothepin in healthy volunteers.


Clinical experience with octoclothepine and lithium in child instability.


Comparison of a combination nortriptyline-amitriptyline and placebo on gastrointestinal diseases in a controlled clinical study.


The action of pyrithioxine in patients with organic encephalopathies.


The effect of aspirin and a compound analgesic on EEG and performance.


Effect of a single dose of palmitoyl ethanolamide on ethanol intoxication in man.


Current genetic problems in the ABO blood group system.


James Sherren--surgeon and sailor.

James Sherren--surgeon and sailor.


Proceedings: the measurement of extracellular fluid volume with radiobromide simultaneous plasma and lymph disappearance in man.


Subcapital fractures of the neck of the femur treated by double-divergent fixation.


Proceedings: can a heterotopically placed segmental liver graft be fully life-supporting? An affirmative finding.


Proceedings: passive enhancement of heterotopic rat heart transplants.


Proceedings: human and computer-aided diagnosis of "dyspepsia".


Proceedings: the feasibility of scaling up the space for implantable prosthetic lungs.


Proceedings: reproducibility of pepsin output and plasma gastrin concentration after insulin in peptic ulcer patients.


Proceedings: the evaluation of gastric pepsin output to insulin in patients with recurrent ulcer.


Mathematical analysis of circulatory mixing process.


Direct and indirect plaque forming cells in extrapulmonary lymphoid tissue following local vs systemic injection of soluble antigen.


Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts.


Ontogenic development of the reactivity of macrophages to antigenic stimulation.


Nude mice--a model system for studying the cellular basis of the humoral immune response.


Ovulating and LH-releasing activity of a highly potent analog of synthetic gonadotropin-releasing hormone.


Treatment of asthma with beclomethasone dipropionate aerosol (preliminary observations).


An investigation of the chlorotriazine derivatives as fixatives for tissues.


The single-cell approach in the visual system and the study of receptive fields.


Chlorinated dibenzodioxins and dibenzofurans.


Letters to the editor: A course in the history of science.


Isolation of Hfr strains from R+ and ColV2+ strains of Escherichia coli and derivation of an R'lac factor by transduction. Temperature-resistant revertants were isolated from Escherichia coli strains carrying a temperature-sensitive dnaA mutation (initiation of chromosome replication) and either a repressed or a derepressed F-like R factor or a ColV2 factor. Many of the revertants had all the properties of Hfr strains, with a variety of directions and origins of transfer. From one such revertant, episomes carrying the R factor and part of the lac region (R'lac) could be isolated by transduction. This system offers a good selection for Hfr strains produced by integration of various episomes and for the isolation of R' factors.


Reversibility of the specific adsorption of colicin E2-P9 to cells of colicin-sensitive strains of Escherichia coli. The adsorption of colicin E2-P9 to its specific receptors on cells of sensitive strains of Escherichia coli is reversible under normal experimental conditions. At temperatures above 20 C, colicin may desorb from one cell and be readsorbed by a second with potentially lethal consequences. However, desorption of colicin seems unable to rescue a cell once it has received a lethal dose. These findings have implications both for the nature and types of specific receptors, and for the assay of colicin by the survivor count (lethal unit) methods.


Loss of an essential function of Escherichia coli by deletions in the thyA region. In an attempt to obtain deletions in the thyA gene, an abnormal lysogen of lambda having the prophage inserted between the thyA and lysA genes was induced, and the surviving cured cells were examined for Thy(-) and Lys(-) mutants. In nearly 10,000 cured cells, 184 Lys(-) but no Thy(-) mutants were found. At the same time, the induced lambda phage contained an approximately equivalent number of lambdathyA(+) and lambdalysA(+) transducing particles. By contrast, in a strain with the genotype F' thyA(-)lysA(+)/ thyA(+)lysA(+), induction of the abnormal lambda lysogen gave rise to many Thy(-) mutants in the cells cured of the prophage. In these Thy(-) mutants it was not possible to eliminate the episome with acridine orange, although the episome could be removed in control cultures with a thyA(+) allele in the resident gene. Therefore, it was suggested that deletion of a gene in the region of the chromosome from the position of the insertion of the lambda prophage through the thyA gene caused loss of an essential and diffusible function.


Isocitrate lyase from a thermophilic Bacillus: effect of salts on enzyme activity. The isocitrate lyase from a thermophilic Bacillus is activated about threefold by a variety of salts. Such strong stimulation of activity is not seen with isocitrate lyase from the mesophiles, Bacillus licheniformis, Bacillus megaterium, Escherichia coli, and Aspergillus nidulans. The salt activation is markedly pH-dependent. At pH values above 8.6, salt (KCl) indeed inhibits the enzyme activity. Potassium chloride also causes a significant shift of the pH optimum of the enzyme towards the acid side. As the temperature of the enzyme reaction is raised, activation becomes progressively weaker. Potassium chloride also affords considerable protection against enzyme denaturation at 55 C. The activation and the stabilization, however, appear to be independent effects. Of six other enzymes in the thermophile that were examined, isocitrate dehydrogenase was equally strongly activated by KCl and malate synthase was less strongly, but significantly, activated; citrate synthase, malate dehydrogenase, glutamate dehydrogenase, and lactate dehydrogenase were unaffected or slightly inhibited by KCl. The property of being strongly activated by salt appears to be a peculiar characteristic of the thermophile isocitrate lyase and possibly evolved concomitantly with its thermostability.


Transformation and physical properties of R-factor RP4 transferred from Escherichia coli to Rhizobium trifolii. Transformation of R-factor RP4 specifying resistance to ampicillin, kanamycin, and tetracycline from Escherichia coli to Rhizobium trifolii is reported. Partially purified RP4 deoxyribonucleic acid (DNA) of the donor strain E. coli J5-3 that carried the R-factor was prepared by the lysozyme-ethylenediaminetetraacetic acid-Triton X-100 procedure and was used in transformation experiments with R. trifolii as recipient. The frequency of transformation of the R-factor into R. trifolii was 1.3 x 10(-4). Dye buoyant density and sucrose gradient centrifugation of R. trifolii DNA showed that the expression of the specified drug resistance of RP4 by R. trifolii was accompanied by the acquisition of an extrachromosomal, satellite DNA component which has indistinguishable physical properties from the R-factor in the donor strain. The significance of the transformation is discussed.


Mycological applications of x-ray microanalysis. In Aspergillus fumigatus, X-ray microanalysis applied in wavelength dispersive spectroscopy enabled us to detect the presence of calcium, potassium, sulfur, phosphorus, and magnesium; and in A. niger we detected the presence of calcium, potassium, chloride, sulfur, phosphorus, sodium, and magnesium. These various elements were identified by their K alpha lines.


Isolation and characterization of circular deoxyribonucleic acid obtained from lactose-fermenting Salmonella strains. Six lac elements originally contained in Salmonella strains were transferred to Escherichia coli WR3026. All of the six E. coli strains that received one of the lac elements were observed to contain supercoiled, circular deoxyribonucleic acid (DNA) when examined by the dye-buoyant density method. Segregants of each of these E. coli WR3026 strains that had lost the ability to utilize lactose, when examined in the same manner as the lactose-fermenting strains, were not observed to contain these supercoiled, circular DNA molecules. Thus the DNA of the lac elements is maintained in E. coli WR3026 in the supercoiled, circular form. Molecular weights of the supercoiled, circular molecules isolated from strains carrying the lac elements were determined by sucrose density gradient centrifugation to be 30 million to 56 million. The calculated number of copies per chromosome of the lac elements varied from 1.4 to 3.7, depending upon the particular lac element examined. Each of the elements was determined to have a guanine plus cytosine composition of 50%. All six of the E. coli WR3026 strains containing a transmissible lac element were tested with the E. coli male-specific phage, R-17, and the E. coli female-specific phage, phiII, and did not respond to either of these phages as do F-containing derivatives of E. coli K-12.


Conjugal deoxyribonucleic acid replication by Escherichia coli K-12: stimulation in dnaB(ts) donors by minicells. R64-11(+) donor cells that are thermosensitive for vegetative DNA replication will synthesize DNA at the restrictive temperature when recipient minicells are present. This is conjugal DNA replication because it is R64-11 DNA that is being synthesized and there is no DNA synthesis if minicells that cannot be recipients of R64-11 DNA are used. The plasmid DNA present in the donor cells before mating is transferred to recipient minicells within the first 20 min of mating, but additional copies of plasmid DNA synthesized during the mating continue to be transferred for at least 90 min. However, the transfer of R64-11 DNA to minicells is not continuous because the plasmid DNA in minicells is the size of one R64-11 molecule or smaller, and there are delays between the rounds of plasmid transfer. DNA is synthesized in minicells during conjugation, but this DNA has a molecular weight much smaller than that of R64-11. Thus, recipient minicells are defective and are not able to complete the synthesis of a DNA strand complementary to the single-stranded R64-11 DNA received from the donor cell.


Conjugal deoxyribonucleic acid replication by Escherichia coli K-12: effect of nalidixic acid. During the conjugal transfer of the R64-11 plasmid at 42 C from donor cells thermosensitive for vegetative deoxyribonucleic acid (DNA) synthesis to recipient minicells, the plasmids are conjugally replicated in the donor cells. This conjugal replication is inhibited by nalidixic acid, and the degree of inhibition is comparable to the reduction in the amount of plasmid DNA transferred to the recipient minicells in the presence of the drug. In addition, the size of DNA transferred to the minicells and the fraction of conjugally replicated DNA in the donor cells that can be isolated as closed-circular plasmid DNA under alkaline conditions are both reduced by nalidixic acid. When the drug is added to a mating that is underway, the rate of conjugal replication is immediately reduced. This change is accompanied by a reduction in the amount of conjugally replicated DNA in the donor cells that can be isolated as closed-circular plasmid DNA. Furthermore, conjugally replicated plasmid DNA that is not associated with the donor cell membrane becomes membrane bound after the addition of nalidixic acid.


Conjugal deoxyribonucleic acid replication by Excherichia coli K-12: effect of chloramphenicol and rifampin. Conjugal replication of R64-11 deoxyribonucleic acid (DNA) and the concomitant transfer of R64-11 DNA to DNA-deficient minicells are dependent upon processes that are inhibited by rifampin and chloramphenicol. The rifampin-sensitive product is not present in vegetatively growing cells and is needed to initiate both conjugal DNA replication in donor cells and DNA transfer to recipient minicells. If the rifampin-sensitive product is a ribonucleic acid (RNA) molecule (rather than RNA polymerase itself), our data indicate that this RNA species required for initiation of conjugal activity does not need to be translated into a protein product. The chloramphenicol-sensitive product(s) is present in vegetatively growing cells in sufficient quantity to permit most donor cells to carry out one round of plasmid conjugal replication and transfer. The initiation of second and subsequent rounds of conjugal replication and transfer are dependent on the synthesis of both the rifampin-sensitive and chloramphenicol-sensitive products. Our results demonstrate a correspondence between the amount of conjugal DNA replication in the donor and the amount of DNA transferred to recipient minicells under all conditions, and therefore suggest but do not prove that plasmid transfer is dependent on conjugal DNA replication. The results also add additional proof that R64-11 transfer to minicells is discontinuous. All of these results are discussed in regard to further refinements of old models for the mechanism of conjugal transfer as well as a more radical departure from current dogma.


Effect of cis-platinum(II)diamminodichloride on wild type and deoxyribonucleic acid repair deficient mutants of Escherichia coli. The anti-tumor drug cis-platinum(II)diamminodichloride (PDD) induced extensive filamentation in wild-type Escherichia coli and in mutants lacking certain deoxyribonucleic acid (DNA) repair functions (uvrA, recB, recC, and polA); viability of repair-deficient mutants treated with PDD was significantly less than that of wild-type cells. PDD was highly toxic to lex1, lex1 uvrA6 (where its effect was cummulative), and recA13 mutants, all of which were killed without formation of filaments. (3)H-thymine incorporated into DNA of cells subsequently treated with PDD became trichloroacetic acid-soluble at rates similar to those observed after exposure to comparable doses of ultraviolet light (UV) or mitomycin C. PDD, like UV, induced extensive degradation of DNA in recA organisms. After a 30-min lag, PDD inhibited significantly the synthesis of DNA but not of ribonucleic acid or protein in E. coli. However, the relative differences between rates of DNA synthesis observed in PDD-treated and control cells decreased substantially when the duration of pulses ((3)H-thymine) was prolonged from 2 to 5 min. These observations suggest that PDD-induced damage to DNA is reversible, possibly by defined mechanisms of excision and recombination repair.


Stringent control of intracellular proteolysis in Escherichia coli. Regulation of intracellular proteolysis has been compared during amino acid deficiencies in seven double auxotrophs of Escherichia coli 9723f with a common phenylalanine requirement. Individual deficiencies were either more effective than, less effective, or equal to phenylalanine deficiency in stimulating intracellular proteolysis. For each amino acid, the same relationship prevailed in inhibiting uracil incorporation into nucleic acids, a reaction series regulated by the rel gene for stringent control. The three amino acids least abundant in the cellular protein were the least effective regulators. These findings are interpreted as supportive evidence for stringent control of intracellular proteolysis by the rel gene.


Multiplicity of leucine transport systems in Escherichia coli K-12. The major component of leucine uptake in Escherichia coli K-12 is a common system for l-leucine, l-isoleucine, and l-valine (LIV-I) with a Michaelis constant (K(m)) value of 0.2 muM (LIV-I system). The LIV-binding protein appears to be associated with this system. It now appears that the LIV-I transport system and LIV-binding protein also serve for the entry of l-alanine, l-threonine, and possibly l-serine. A minor component of l-leucine entry occurs by a leucine-specific system (L-system) for which a specific leucine-binding protein has been isolated. A mutant has been obtained that shows increased levels of the LIV-I transport activity and increased levels of both of the binding proteins. Another mutant has been isolated that shows only a major increase in the levels of the leucine-specific transport system and the leucine-specific binding protein. A third binding protein that binds all three branched-chain amino acids but binds isoleucine preferentially has been identified. The relationship of the binding proteins to each other and to transport activity is discussed. A second general transport system (LIV-II system) with a K(m) value of 2 muM and a relatively low V(max) can be observed in E. coli. The LIV-II system is not sensitive to osmotic shock treatment nor to growth of cells in the presence of leucine. This high K(m) system, which is specific for the branched-chain amino acids, can be observed in membrane vesicle preparations.


Hydroxyethylthiazole uptake in Escherichia coli: general properties and relationship between uptake and thiamine biosynthesis. Uptake of (35)S-hydroxyethylthiazole (4-methyl-5-hydroxyethylthiazole) by Escherichia coli intact cells was studied. Hydroxyethylthiazole was taken up in the presence and absence of glucose at the same rate. The uptake was almost proportional to a hydroxyethylthiazole concentration gradient up to 0.1 mM with no tendency of saturation, and reached a steady state within 2 min. When the cells were treated with 1 mM N-ethylmaleimide, about 50% inhibition of hydroxyethylthiazole uptake was observed. Hydroxyethylthiazole uptake was stimulated by the addition of hydroxymethylpyrimidine (2-methyl-4-amino-5-hydroxymethylpyrimidine), and this effect was further enhanced in the presence of glucose. For full activation of hydroxyethylthiazole uptake, 1 muM hydroxymethylpyrimidine was necessary in the presence of glucose. The rate of hydroxyethylthiazole uptake was almost linear up to 60 min in the presence of hydroxymethylpyrimidine and glucose. Hydroxymethylpyrimidine monophosphate and its pyrophosphate could not stimulate the uptake. Thiamine and 2-amino-hydroxyethylthiazole were inhibitory on hydroxyethylthiazole uptake in the presence of hydroxymethylpyrimidine and glucose. N-ethylmaleimide and 2, 4-dinitrophenol were also inhibitory. No stimulatory effect of hydroxymethylpyrimidine on hydroxyethylthiazole uptake was observed in mutant cells lacking either thiaminephosphate pyrophosphorylase or hydroxymethylpyrimidine monophosphate kinase. The possibility of direct participation of thiamine-synthesizing enzymes in hydroxyethylthiazole uptake was discussed.


Single-strand breaks in deoxyribonucleic acid and viability loss during deoxyribonucleic acid synthesis inhibition in Escherichia coli. The effects of deoxyribonucleic acid (DNA) synthesis inhibition brought about in four different ways-thymidine starvation, nalidixic acid, hydroxyurea, and dnaB mutation-were examined in isogenic strains of Escherichia coli K-12. Three parameters were examined to determine whether there are strict correlations among them: (i) the extent of DNA synthesis inhibition; (ii) cell survival; and (iii) the rate of breakage of DNA molecules. There was no significant correlation between the extent of DNA synthesis inhibition and the rate of viability loss caused by the four DNA synthesis inhibitors, nor was there a strict correlation between the rate of occurrence of single-strand breaks in DNA and loss of viability. During treatment with hydroxyurea (0.1 M), no viability loss was observed and little, if any, single-strand breakage of DNA occurred. Both thymidine starvation and nalidixic-acid (20 mug/ml) treatment resulted in viability loss and breakage of DNA. For these latter two inhibitors, the two events appeared to be associated because greater rates of both viability loss and DNA breakage were observed for nalidixic acid compared with thymidine starvation. However, viability loss need not be associated with extensive breakage of DNA as demonstrated with a temperature-sensitive DNA synthesis mutant; at 39 C, viability loss occurred at a high rate without significant DNA breakage. With the other agents, the amount of DNA breakage accumulated when a cell population has sustained an average of one lethal hit was estimated to be about 30 single-strand breaks per genome. Differences in chromosomal and episomal breakage rates were observed.


Defects in prodigiosin formation by L-forms of Serratia marcescens. An L-form of Serratia marcescens has previously been shown incapable of producing the red pigment, prodigiosin, characteristic of the parent bacteria. Mutants of S. marcesens, unable to form one or the other of the two prodigiosin precursors, 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde or 2-methyl-3-n-amylpyrrole, were used to test the nature of the L-form defect. The L-forms failed to form sufficient amounts of either precursor to be detected by the appropriate mutant, and, when furnished the precursors, failed to couple them to form prodigiosin.


Effect of rifampin on the structure and membrane attachment of the nucleoid of Escherichia coli. Deoxyribonucleic acid (DNA) of Escherichia coli was found to be attached to the cell membrane at about 20 points. This was determined by fractionation of X-irradiated cells with the M band (magnesium-Sarkosyl crystals) technique. The number of attachment points was computed from the relationship between the amount of DNA in M bands and the number of double-strand breaks introduced by the X-ray treatment. The number of attachment points was decreased fourfold by treatment of cells with rifampin. This effect was apparently due to the action of the drug on ribonucleic acid (RNA) polymerase since the drug did not affect a mutant whose RNA polymerase is resistant to rifampin. This suggests that there may be two classes of attachment points of DNA on the membrane, some of which are removed by rifampin treatment and some which are not. Rifampin treatment also resulted in the uncondensing of isolated nucleoids and in an axial appearance of the nucleoids in ultrathin sections. The results suggest that RNA polymerase plays a role, direct or indirect, in maintaining the structure of the bacterial nucleoid and in some of its attachment to the membrane.


Abnormal cell envelope ultrastructure of a Saccharomyces mutant with invertase formation resistant to hexoses. The most obvious morphological characteristic of Saccharomyces mutant FH4C cells is the tendency to form clumps (production of invertase and alpha-glucosidase by this mutant is highly resistant to repression by hexoses). This peculiar feature arises from the abnormal cell envelope ultrastructure of the mutant. Clumps are formed as a result of the failure of the cell wall of the bud to separate from that of the mother cell. The cell wall also shows irregular thickening. There are many cells with a doughnut shape and with small budlike protrusions. Abnormal septation and wall invagination into vacuoles give rise to cells of differing sizes and irregular profiles. Many vesicles, tubules, and coiled membranous bodies originate from invaginations of the plasmalemma. These structures are frequently observed in the cell wall or the periplasmic space. The cells of mutant FH4C growing in 0.2 M glucose, unlike parent strain 303-67, contain many mitochondria. Large numbers of glycogen deposits are also found in many cells of FH4C.


Nuclear apparatus of Hyphomicrobium.

Nuclear apparatus of Hyphomicrobium. The nuclear apparatus of Hyphomicrobium sp. strain B-522 is examined by various microscopy and radiolabeling techniques to determine its behavior during the reproductive cycle of these bacteria. The young, swarmer cell contains a single nucleoid comprised of a deoxyribonucleic acid (DNA) molecule with a molecular weight of 3.1 x 10(9). After development of the swarmer into a mature mother cell with a hypha and bud, the nucleoid replicates and separates into two daughter nucleoids during the initial stages of bud formation. After further development of the bud, one of the daughter nucleoids in the mother cell is rapidly transferred through the hypha to the bud. Half of the old DNA strands pass to each consecutive generation of daughter cells, but only 43% of the stable ribonucleic acid is transferred. The role which the hypha plays in the developmental cycle of these bacteria is discussed, and a mechanism for nuclear transfer is proposed.


The lon Gene and Degradation of β-Galactosidase Nonsense Fragments N-terminal beta-galactosidase fragments are rapidly degraded in growing cells of Escherichia coli. Mutations in the lon gene are sufficient to enhance the stability of these polypeptides.


Stability of Candida utilis cells and spheroplasts toward gravitational forces. Candida utilis cells and spheroplasts containing uric acid crystals in their vacuoles were not damaged by the mechanical stress of centrifugation at 20,000 x g for 10 min, as judged by plating, microscopy, and spectrophotometry.


Determination of the length of the V colicinogenic factor and a derivative fertility factor. Plasmid deoxyribonucleic acid from Escherichia coli harboring either the V colicinogenic factor (Col V) or the derivative fertility factor (Fv), (a non-colicin-producing fertility factor derived from Col V) were separated by cesium chloride-ethidium bromide centrifugation and examined by electron microscopy. Results indicate a deletion of 11 mum of deoxyribonucleic acid in the transition from Col V to Fv.


Phospholipid turnover in a conditional polyamine auxotroph of Escherichia coli. Polyamines are required for rapid phospholipid turnover in Escherichia coli growing in media of low osmolarity.


Particular influence of leucine peptides on lysyl-transfer ribonucleic acid ligase formation in a mutant of Escherichia coli K-12. l-Leucine dipeptides can enhance lysyl-transfer ribonucleic acid ligase activity 15- to 20-fold in a mutant of Escherichia coli K-12. Evidence indicates the peptides act per se.


Aspartate transcarbamylase. A study of possible roles for the sulfhydryl group at the active site.


The isolation and general properties of Escherichia coli malonyl coenzyme A-acyl carrier protein transacylase.


Detection of inosine-containing transfer ribonucleic acid species by affinity chromatography on columns of anti-inosine antibodies.


Characterization of a malonyl-enzyme intermediate and identification of the malonyl binding site in malonyl coenzyme A-acyl carrier protein transacylase of Escherichia coli.


The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. IV. Characterization of kinetic effect of adenosine monophosphate.


The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. V. Relation between ligand-induced allosteric activation and the protomeroligomer interconversion.


A trial of clotrimazole and nystatin in vaginal moniliasis.


The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. VI. Identification of the partial reaction activated by adenosine monophosphate.


Pneumopericardium and pneumomediastinum in infants and children.


Use of continuous positive airway pressure breathing in the improved management of neonatal emergencies.


Comparison of xenograft and prosthesis for burn wound care.


An experimental study of the vibrator in postoperative tracheobronchial clearance.


Excision of giant nevus in newborn.

Excision of giant nevus in newborn.


Studies on protein passage through arterial endothelium. 3. Effect of blood pressure levels on the passage of fine structural protein tracers through rat arterial endothelium.


Hemodynamic characteristics of primary aldosteronism.


Editorial: Hypertension control--the challenge of patient education.


Letter: Hypouricemia after renal transplantation.


Duncan Earl Reid, M.D., 1905-1973.

Duncan Earl Reid, M.D., 1905-1973.


Samuel James Thompson.

Samuel James Thompson.


Mark Graham Somerville.

Mark Graham Somerville.


Procedures for the isolation of lipopigments from brain, heart and liver, and their properties: a review.


Progress in Allergy. Introduction.

Progress in Allergy. Introduction.


Measurement of synovial fluid volume by a radioisotope method.


Biographic sketch of Winfield W. Scott, M.D.


The American Board of Urology. Past and future.


Renal dialysis and kidney transplantation program for the state of Maine.


Sony-W sharing of cadaver kidneys for transplantation.


Host lymphocyte transformation in lymph of canine kidney allograft.


Renal preservation. A modified solution for 18 hours of protection.


Transureteroureterostomy. Experience in pediatric patient.


Willam Osler on penis captivus and other urologic topics.


Effect of acidosis on rate of urinary calcium excretion in transplanted human kidney.


Rejection of skin and conjunctival allografts in the dog after prolonged graft survival.


Management of the perineal wound after rectal excision.


Graft and patient survival after primary cadaver kidney transplantation with special regard to compatibility in the HL-A system.


Mucosal blood circulation and its influence on passive absorption in the small intestine. An experimental study in the cat.


A simple method for the separation of single-stranded and double-stranded RNA on hydroxyapatite.


A multiple adapter for the SW 25 rotor.

A multiple adapter for the SW 25 rotor.


A method for characterization and fractionation of deoxyribonucleic acid by continuous turbidimetry of cetyltrimethylammonium-DNA precipitates.


Dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli: dihydrofolate monooxygenase activity.


Cytokinins regulate calcium binding to a glycoprotein from fungal cells.


Involvement of dolicholmonophosphate in the formation of specific mannosyl-linkages in yeast glycoproteins.


N-terminal sequence of swine pepsinogen and pepsin. The site of pepsinogen activation.


Ribosome degradation in Escherichia coli induced by colicin E2.


Correction for non-uniform phosphate labeling of E. coli and phage RNAs synthesized in vivo.


RNase catalyzed hydrolysis of ribosomes in several functional states.


Synthesis of a peptide with full somatostatin activity.


Bromide ion probe N.M.R. studies of glutamate decarboxylase (E. coli).


The involvement of 5S RNA in the binding of tRNA to ribosomes.


Red cell 2,3-diphosphoglycerate.

Red cell 2,3-diphosphoglycerate.


Letter: Tetracycline-resistant beta-haemolytic streptococci.


Letter: Muscle cramps during maintenance haemodialysis.


H.B. Stallard.

H.B. Stallard.


H.L. Cronk.

H.L. Cronk.


T.E. Anderson.

T.E. Anderson.


R.F. Loeb.

R.F. Loeb.


Autoantibodies directed against heart antigens and endocrine reactivity in patients with recent myocardial infarction.


Electrocardiographic prediction of unmodified rejection in heterotopic canine cardiac allografts.


Studies on the decarbosylation of pyruvate. II.  Kinetic studies on the binding of thiamine pyrophosphate to pyruvate decarboxylase.


Introduction to special issue on computer-assisted instruction in the health sciences.


ATS in exposition.

ATS in exposition.


CASE--a natural language computer model.


GENESYS--a generating system for the CASE natural language model.


A return to a dedicated machine for computer-assisted instruction.


CAI at the Ohio State University College of Medicine (1973).


Distribution of computer-assisted instructional materials in biomedicine through the Lister Hill Center Experimental Network.


A selected bibliography to computerized instruction in the health sciences.


Limbal vascular response prior to corneal vascularization.


Pivampicillin: a preliminary report of its pharmacokinetic properties and therapeutic efficacy.


On the role of pH in the sporulation of Saccharomyces cerevisiae.


Studies on the phagocytic activity of the reticuloendothelial system (RES) to rough and smooth Escherichia coli in young conventional and germfree guinea pigs.


The in vitro phagocytic activity of guinea-pig macrophages to Salmonella typhi and Salmonella enteritidis.


Colicins of Escherichia coli strains causing urinary tract infections, sensitivity of these strains towards colicins, and their O-serotypes.


Effects of cholestyramine, metamucil, and cellulose on fecal bile salt excretion in man.


Radiology of the liver and biliary tract.


Pathophysiological response of rabbit jejunum to Escherichia coli enterotoxin.


The hypothalamo-hypophysial system of the frog Rana temporaria. I. Morphometric analysis of functional states of the median eminence.


Serum factors affecting the incorporation of (3H)thymidine by lymphocytes stimulated by antigen. I. Serum concentration.


Direct stimulation of lymphoid tissue of the chicken. 3. Haemagglutinin production, haemolysin-forming cells and changes in lymphoid tissues following injection of guinea-pig erythrocytes into the bone marrow.


Mechanisms of suppression of the immune response. I. Differences in the effect of specific inhibitory antibody on distribution of 51CR-labelled sheep erythrocytes in different mouse strains.


The effect of high sugar concentrations on the heat resistance of vegetative micro-organisms.


A comparison of two methods for obtaining anaerobic counts in different segments of the gastro-intestinal tract of piglets.


The presence of Clostridium botulinum in Indonesian waters.


The effect of endotoxin on murine stem cells.


Electrophysiological observations on immature rat nerve cells grown in tissue culture.


Functional evaluation of pituitary reserve in patients with the amenorrhea-galactorrhea syndrome utilizing luteinizing hormone-releasing hormone (LH-RH), L-dopa and chlorpromazine.


Gonadotropin response to synthetic LH-RH in normal subjects: correlation between LH and FSH.


The estimation of pituitary luteinizing hormone secretion.


Metabolism of tritiated 25-hydroxycholecalciferol in chronically uremic children before and after successful renal homotransplantation.


Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies.


Fine structure of vesicles induced in chloroplasts of Chinese cabbage leaves by infection with turnip yellow mosaic virus.


The neural spread of pseudorabies virus in calves.


The infection of tobacco protoplasts with cowpea chlorotic mottle virus and its RNA.


Letter: Hypersusceptibility and genetic problems.


Recent developments in industrial carcinogens.


Studies on plasma insulin levels in the posttraumatic phase in rabbits.


Method of preparing washed suspensions of anaerobic bacteria for metabolic studies.


Intrarenal blood flow distribution in irreversible hemorrhagic shock in dogs.


The effects of daunomycin and ethidium bromide on Escherichia coli.


Pleiotropic mutations in Serratia marcescens which increase the synthesis of certain exocellular proteins and the rate of spontaneous prophage induction.


Gene dosage studies with pleiotropic mutants of Serratia marcescens superactive in the synthesis of marcescin A and certain other exocellular proteins.


Studies on lambda virulent mutants. II. Anti-repression and Vir-repression function of lambdavirC and lambdavirCvirR.


Comparison between the chromosomal maps of Escherichia coli and Salmonella typhimurium. Length of the inverted segment in the trp region.


Isolation from Salmonella typhimurium LT2 of mutants lacking specifically nitrate reductase activity and mapping of the chl-C gene.


Repair defect mutants of Proteus mirabilis. II. Excision of pyrimidine dimers from the DNA of ultraviolet-irradiated P. mirabilis wildtype and UV-sensitive mutants.


Doxycycline (Vibramycin) in chronic renal failure.


Orthogonal factors vs. interdependent variables as predictors of drug treatment response in anxious outpatients.


Eight- and twenty-four-hour canine pancreas preservations using a simple gel cooling technique.


Cellular and humoral immunity after allogeneic transplantation in the rat. II. Comparison of a 51Cr release assay and modified microcytotoxicity assay for detection of cellular immunity and blocking serum factors.


Cellular and humoral immunity after allogeneic transplantation in the rat. 3. The effect of passive antibody on cellular and humoral immunity after allogeneic renal transplantation.


Cellular and humoral immunity after allogeneic transplantation in the rat. IV. The effect of heterologous antilymphocyte serum on cellular and humoral immunity after allogeneic renal transplantation.


Factors responsible for the differential survival of heart and skin allografts in inbred rats.


Medicaid fee structures inequitable.

Medicaid fee structures inequitable.


The antigenicity of mouse tooth germs. I. Isogenic and allogenic transplantation.


Histoincompatibilities found between congenic strains which differ at loci determing differentiation antigens.


Yeasts grown on hydrocarbons as new sources of protein.


Amino acid homeostasis in the gut lumen and its nutritional significance.


A nutrition policy for Nigeria.

A nutrition policy for Nigeria.


Adaptations of the digestive tract during reproduction in the mammal.


Yam--a valuable source of food and drugs.


Some effects of dietary sucrose.

Some effects of dietary sucrose.


Some aspects of the effects of different methods of production and of processing on the nutritive value of food.


Animal diseases as contributors to human hunger problems of control.


Nutrition and brain function.

Nutrition and brain function.


Sulfur in ruminant nutrition.

Sulfur in ruminant nutrition.


Rickets in developing countries.

Rickets in developing countries.


Editorials: Statistical problems in clinical trials: the UGDP study revisited.


Roland F. Schoen, M.D. 1913-1973.

Roland F. Schoen, M.D. 1913-1973.


Role of behavior genetics in psychology.


The "Flying Chlamydospore"--its discovery in the Salt River Valley and the Presidio of Tucson.


Contact mattress to prevent heat loss in neonatal and paediatric surgery.


Proceedings: A preliminary study of oral premedication with oxypertine.


Oral lesions in dermatitis herpetiformis.


Induction of epithelial hyperplasia by Candida albicans.


Lupus erythematosus in association with finger-clubbing.


Assessment of man's thermal comfort in practice.


Editorial: Commemoration and taking stock.


The impact of radiology on cardiology.

The impact of radiology on cardiology.


Reflections on early X-ray engineering.

Reflections on early X-ray engineering.


Looking back on radiology. Radiological physics--a retrospect.


Early days of experimental radiology.

Early days of experimental radiology.


Radiology in the twenties.

Radiology in the twenties.


Radiotherapy 1925-1959.

Radiotherapy 1925-1959.


Ultrasonics and its use in medicine.

Ultrasonics and its use in medicine.


Cuthbert Andrews 1882-1972.

Cuthbert Andrews 1882-1972.


The evolution of the British Journal of Radiology.


Letter: W. K. Röntgen.

Letter: W. K. Röntgen.


Seventy-five years of radiological physics.


The British x-ray industry: a brief historical survey.


Seventy-five years of radiation protection.


Seventy-six years of British radiology.

Seventy-six years of British radiology.


Cineradiography.

Cineradiography.


The development of radioisotope scanning techniques.


Medical ultrasonics: an historical review.


Hodgkin's disease: a review of changes over 40 years.


Rationalizing radiotherapy: some historical aspects of the endeavour.


Intramolecular motion in peptide determined by 13C NMR: a spin-lattice relaxation time-study on MSH-release-inhibiting factor.


Direct measurement and kinetic analysis of the association of E. coli ribosomal subunits.


Affinity labeling of E. coli ribosomes with a streptomycin-analogue.


Complex formation of daunomycin with double-stranded RNA.


Reductive methylation: a method for preparing functionally active radioactive ribosomes.


Current trends in chemical carcinogenesis.


The biochemist's outlook on cancer research.


Endocrine mechanisms in marine invertebrates.


Using fructose in the treatment of delirium tremens.


An ethologic search for self-administration of hallucinogens.


Effects of microelectrophoretically administered cortisol on single cell activity in the tuberal hypothalamus of the rat.


Blood stain identification as described in the Talmud.


Bibliography of paper and thin-layer chromatography 1966-1969. Compounds containing heterocyclic oxygen.


Bibliography of paper and thin-layer chromatography 1966-1969. Steroids.


Bibliography of paper and thin-layer chromatography 1966-1969. Cardiac glycosides and saponins. Cardiac glycosides and their genins.


Bibliography of paper and thin-layer chromatography 1966-1969. Amines, amides, and related nitrogen compounds.


Bibliography of paper and thin-layer chromatography 1966-1969. Nitro and nitroso compounds.


Bibliography of paper and thin-layer chromatography 1966-1969. Peptides.


Bibliography of paper and thin-layer chromatography 1966-1969. Amino acids.


Bibliography of paper and thin-layer chromatography 1966-1969. Proteins.


Bibliography of paper and thin-layer chromatography 1966-1969. Elucidation of the primary structure of peptides and proteins.


Bibliography of paper and thin-layer chromatography 1966-1969. Purines, pyrimidines, nitrogenous constituents of nucleic acids.


Bibliography of paper and thin-layer chromatography 1966-1969. Alkaloids.


Bibliography of paper and thin-layer chromatography 1966-1969. Other compounds with heterocyclic nitrogen.


Bibliography of paper and thin-layer chromatography 1966-1969. Pesticides.


Bibliography of paper and thin-layer chromatography 1966-1969. Vitamins.


Bibliography of paper and thin-layer chromatography 1966-1969. Applications in pharmacy and toxicology.


Cleidocranial dysostosis: report of a case.


Literature on mercury: availability of English translations.


Operations research in health services.

Operations research in health services.


Brain abscess. Review of 89 cases over a period of 30 years. Eighty-nine cases of brain abscess, diagnosed over a period of 30 years, are reviewed. The incidence of this disease did not decline throughout the period. Abscesses of ear and nose origin constituted the largest group (38%). Postoperative abscesses seem to have increased in incidence, presumably due to routine postoperative antibiotic treatment. Antibiotics were possibly responsible for the suppression of signs of infection in 45% of the patients, who presented as suffering from a space-occupying lesion. The most accurate diagnostic tool was angiography, which localized the lesion in 90% and suggested its nature in 61%. Brain scan may prove as satisfactory. Staphylococcus was cultured in about two-thirds of the cases. Mortality seemed to decrease concomitantly with the advent of more potent antibiotics. The treatment of choice in terms of both mortality and morbidity seemed to be enucleation after previous sterilization. The hazards of radical surgery should be taken into consideration.


Operations research in the medical field.


A method for measuring cell cycle phases in suspension cultures.


A replica plating method of cultured mammalian cells.


Cultivation of cells in protein- and lipid-free synthetic media.


Isolation of mutants of cultured mammalian cells.


Isolation of metaphase chromosomes, mitotic apparatus, and nuclei.


Isolation of metaphase chromosomes with high molecular weight DNA at pH 10.5.


Production and characterization of mammalian cells reversibly arrested in G1 by growth in isoleucine-deficient medium.


Preparation of synchronous cell cultures from early interphase cells obtained by sucrose gradient centrifugation.


Sphingosine metabolism and its link to phospholipid biosynthesis.


Formation of pure and mixed clones of c mutants in serratiaphage sigma after treatment of the free virion with UV or hydroxylamine.


Some differences between 470 nm and 510 nm in the acridine-orange-sensitized photodynamic actions on yeast cells.


H-gene (histocompatibility) mutations induced by triethylenemelamine in the mouse.


The biosynthesis of methionine.

The biosynthesis of methionine.


Hemoglobins from trout: structural and functional properties.


The glycine cleavage system: composition, reaction mechanism, and physiological significance.


Heterogeneity of suppressor revertants in E. coli revealed as a result of introduction of the strA- gene.


Sagittectomy--first recorded surgical procedure in the American Southwest, 1535. The journey and ministrations of Alvar Nuñez Cabeza de Vaca.


Fever of undetermined origin.

Fever of undetermined origin.


Lepra cells in synovial fluid of a patient with erythema nodosum leprosum.


Thermophilic fungi in a municipal waste compost system.


George Willard Martin (1886-1971).

George Willard Martin (1886-1971).


Cytonucleoproteins: a two-dimensional electrophoretic analysis.


Variation in isolates of Chaetomium trilaterale.


Concerning irradiation-induced biological activity alterations of tetracycline.


Effect of gold thioglucose in the domestic fowl.


Situationism in psychology: an analysis and a critique.


The effects of herbicides on the ultrastructure of plant cells.


Factors influencing soil adsorption and bioactivity of pesticides.


The metabolism and degradation of vinyl phosphate insecticides.


William C. Bradbury 1907-1971.

William C. Bradbury 1907-1971.


Donald J. Thorp 1895-1971.

Donald J. Thorp 1895-1971.


Donald A. Dallas 1898-1971.

Donald A. Dallas 1898-1971.


Henry Augustus Stephenson 1887-1971.

Henry Augustus Stephenson 1887-1971.


Duncan Reese Neilson 1911-1971.

Duncan Reese Neilson 1911-1971.


Tobramycin in the neonatal period.

Tobramycin in the neonatal period.


Dilemma of herniated lumbar disc. Experience with over 1,200 surgical cases.


Diseases of children. 50 years of continuous practice.


Editorial: Our new president: John A. Martin, M.D.


Topical Corticosteroids International Symposium, Venice, May 1972. Introductory remarks.


Procedures for the clinical investigation of a topical corticosteroid.


Haemorrhagic cystitis complicating cyclophosphamide treatment in children.


Studies on the antibody formation of the cultured omentum cells using hemolytic plaque method.


Impaired delayed hypersensitivity in subacute sclerosing panencephalitis.


The continuing search for antiviral drugs.


Chemotherapy of anaplasmosis, babesiasis, and theileriasis.


A decision procedure for automated cytology: test statistic for detecting sample abnormality, and inadequacy.


Prediction of pharmacological activity by the method of physicochemical-activity relationships.


Gustav Bychowski: an appreciation.

Gustav Bychowski: an appreciation.


Scanning electron microscopy of normal exfoliated squamous cervical cells.


Computer discrimination of cells in serous effusions. II. Peritoneal fluid.


Autoradiographic distribution of collagen loss in skin grafts.


The fine structure of the ultimobranchial body of the chick.


Biosynthesis of methionine and its control in wild type and regulatory mutants of Saccharomyces cerevisiae.


Studies on synthetic inhibitors of t-RNA methyl transferases: analogs of S-adenosyl homocysteine.


Total replacement of 116 hips by the McKee-Farrar prosthesis. A preliminary report.


Factors determining the specificity of the tRNA aminoacylation reaction. Non-absolute specificity of tRNA-aminoacyl-tRNA synthetase recognition and particular importance of the maximal velocity.


Trapezoidal-28 total hip replacement.

Trapezoidal-28 total hip replacement.


Editorial: Total hip replacement.

Editorial: Total hip replacement.


Chondroblastoma of bone. A critical review.


UV protective effects of 5-fluorouracil and thymidine.


Ferdinaud Springer Lecture: initiation of transcription by RNA polymerases of E. coli and phage T3.


The mechanism of maintenance of electroneutrality during the transport of gluconate by E. coli.


Hemodynamic response to discontinuance of mechanical ventilation.


Bongkrekic acid resistant mutants of Saccharomyces cerevisiae.


Avilamycin, an inhibitor of the 30 S ribosomal subunits function.


In situ regulation of yeast citrate synthase. Absence of ATP inhibition observed in vitro.


Simplified physiologic management of status asthmaticus in children.


The mitochondrial DNA of hamster-mouse hybrid cells.


Letter: Prevention of injection phlebitis.


The American society for gastrointestinal endoscopy. Membership list: 1973.


An improved method to split the epidermis of mammals into its constituent layers: preliminary report.


Determination of N,N-dimethyldibenzo(b,f)thiepin-10-methylamine by gas-liquid chromatography.


Bibliography section. Paper chromatography.


Thin-layer chromatography.

Thin-layer chromatography.


Column chromatography.

Column chromatography.


Gas chromatography.

Gas chromatography.


Electrophoretic techniques.

Electrophoretic techniques.


Intracellular localization of lens antigens in the developing eye of the mouse embryo.


Lens differentiation from the cornea following lens extirpation or cornea transplantation in Xenopus laevis.


The physics of porous membranes--neutral pores.


Negative conductance and electrodiffusion in excitable membrane systems.


The determination of left ventricular end-diastolic volume (EDV) by means of 133Xe wash-out.


Transport across ion-exchange resin membranes: the frictional model of transport.


Experimentally observed effects of carriers on the electrical properties of bilayer membranes--equilibrium domain. With a contribution on the molecular basis of ion selectivity.


Theoretical analysis of ion conductance in lipid bilayer membranes.


Alkali cation specificity of carrier antibiotics and their behavior in bulk membranes.


Aqueous pores created in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B.


Protein-mediated mechanisms of variable ion conductance in thin lipid membranes.


Electrochemical properties of thick membranes with macrocyclic antibiotics.


Theoretical analysis of carrier-mediated electrical properties of bilayer membranes.


Interaction between Coxiellae burnetii and the cells in experimental Q-rickettsiosis. Histologic and electron microscope studies.


Editorial: Leprous leukoderma.

Editorial: Leprous leukoderma.


Dam, reservoir of filter.

Dam, reservoir of filter.


Sarcina species on the skin of the human forearm.


McCollum Award: Charles S. Lieber, M.D.

McCollum Award: Charles S. Lieber, M.D.


Oxalate metabolism. IV.

Oxalate metabolism. IV.


Nutrition and health of older people.

Nutrition and health of older people.


Long-term effects of maternal and infant feeding.


Feeding the elderly.

Feeding the elderly.


A computer interview for suicide-risk prediction.


1973 anniversaries.

1973 anniversaries.


True and false experts: a second look.

True and false experts: a second look.


Letter: Surgery using hypnosis in 1845.

Letter: Surgery using hypnosis in 1845.


The relationship of oral contraception to depressive symptoms.


Solid phase synthesis of growth hormone-release inhibiting factor.


Modern concepts in ophthalmic casualty management.


Sensitization of D-glucuronic acid transport system of E. coli to protein group reagents in presence of substrate or absence of energy source.


Changes in accessibility of the membrane bound transport enzyme glucose phosphotransferase of E. coli to protein group reagents in presence of substrate or absence of energy source.


Identification and property of the mutagenic principle formed from a food-component, methylguanidine, after nitrosation in simulated gastric juice.


A catenated DNA molecule as an intermediate in the replication of the resistance transfer factor R6K in Escherichia coli.


Nature of the EF G-dependent binding of 3H-GMPPCP to ribosomes.


L-phenylalanyl-tRNA synthetase of E. coli. Active site specific binding of 2-p-toluidinylnaphthalene-6-sulfonate.


Meyer X. Zarrow November 1, 1913-January 23, 1973.


Effect of zinc deficiency and restricted food intake on plasma and pituitary LH and hypothalamic LRF in female rats.


The use of amoxycillin in treatment of urinary tract infection in general practice.


Pheneturide in epilepsy: preliminary communication.


A preliminary clinical trial of hydrocortisone-17-butyrate.


Analysis of cell division in rapidly growing synchronous cultures of Escherichia coli recovering from an inhibition of deoxyribonucleic acid synthesis.


Temperature-gradient incubator for the growth of clostridia.


Toxoplasmosis in Rhodesia.

Toxoplasmosis in Rhodesia.


Study of the thymic-derived or -independent nature of mouse spleen cells induced to proliferate in culture by various mitogens and antigens.


Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. I. Target cells and possible mode of action.


Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions.


Surface immunoglobulin of myeloma cells.


The failure to transfer the NZB disease following implantation of NZB thymus-containing chambers.


The IPPF: 21 years of achievement.

The IPPF: 21 years of achievement.


The status of women and fertility.

The status of women and fertility.


Genetic counseling.

Genetic counseling.


Selected studies of the menopause.

Selected studies of the menopause.


In vivo methylation of replicating bacteriophage phi chi174 DNA.


DNA synthesis during bacterial conjugation. I. Effect of mating on DNA replication in Escherichia coli Hfr.


DNA synthesis during bacterial conjugation. II. Is DNA replication in the Hfr obligatory for chromosome transfer?


Chemical and enzymatic modification of proteins in the 30 S ribosome of Escherichia coli.


Topography of the Escherichia coli 30 S ribosome revealed by the modification of ribosomal proteins.


Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits.


Letter: Conformational changes in ribosomal subunits following dissociation of the Escherichia coli 70 S ribosome.


Aleksandr Vladimirovich Palladin 1885-1972.


Ernst Klenk 1896-1971.

Ernst Klenk 1896-1971.


Retention of the original topographic polarity by the 180 degrees rotated tectal reimplant in young adult goldfish. 1. The pattern of visual projection from the retina on to the optic tectum was studied with neurophysiological mapping methods following reimplantation of the optic tectum in young adult goldfish.2. When a rectangular piece of the tectum was dissected out and then reimplanted to the same tectum in situ, the restored visual projection showed a normal retinotopic order over the area of the tectal reimplant.3. If the tectal tissue was reimplanted after rotation by 180 degrees , the visual projection from that part of the retina which innervated the 180 degrees rotated tectal reimplant was found to be organized in a completely reverse retinotopic order within the reimplanted area in contrast to the normal projection from the other part of the retina on to the intact surrounding area of the same optic tectum.4. The results indicate that a piece of reimplanted tectal tissue retains its original topographic polarity regardless of whether the tectal tissue was rotated or not.5. The retention of original topographic polarity by a small fraction of the tectal tissue suggests that the optic tectum is not a passive receiver of incoming optic fibres but an active accommodator which selects appropriate optic fibres to make proper synaptic connexions in a consistent topographic order.


Behavior therapy and stuttering: a review.


Synchronous initiation of lac mRNA transcription.


Letter: a suggested function of RNA-linked fragments in DNA replication.


Editorial: A good word for cholesterol.

Editorial: A good word for cholesterol.


Massive early proteinuria following renal homotransplantation.


Detoxification of rehabilitated methadone-maintained patients.


Ascites. An unusual manifestation of urinary leak in a renal allograft recipient.


A review of cis AB blood.

A review of cis AB blood.


Tumor immunity induced by BCG-tumor cell mixtures in syngeneic mice.


Syphilis in pregnancy: transplacental infection.


Editorial: Karitane's jubilee.

Editorial: Karitane's jubilee.


Letter: "Cingulotractotomy" and leucotomy.


Treatment of medically intractable mental disease by limited frontal leucotomy--justifiable?


Gas gangrene.

Gas gangrene.


Letter: Levamisole and the immune response.


Recovery from "hepatorenal syndrome" after orthotopic liver transplantation.


Pulmonary arterial abnormalities in the sudden-infant-death syndrome.


By the London post. Portfolio for health--policy on heart transplants--Labour Party's health plans.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 48-1973.


Editorial: Hepatorenal and glomerulotubular imbalance.


Depression of thymine dimer excision without an adequate effect on survival in Escherichia coli B-r Hcr+ cells.


Congenital abnormalities of the uterus and foetal wastage.


In memoriam: Robert Stevenson.

In memoriam: Robert Stevenson.


Treatment of septicaemic shock in gynaecology and obstetrics.


Harry Berelowitz.

Harry Berelowitz.


Alec Singer.

Alec Singer.


Editorial: Autoregulation of interstitial fluid volume. Edema-preventing mechanisms.


The role of donor passenger leukocytes in rat skin allograft rejection.


The behavior of male skin grafts in isogenic postpartum female mice.


Immunogenetic detection of B locus genotypes in chickens with autoimmune thyroiditis.


Successful intravenous pyelography of end stage kidneys following transplantation.


Cell-mediated immunity and blocking serum activity before and after breakage of allograft tolerance in rats.


Homing properties of thymus-independent follicular lymphocytes.


The uptake of 125I-labeled rat alloantibody and its loss after combination with antigen.


Blood transfusions and unresponsiveness to HL-A.


Orthotopic transplantation of tooth buds among histoincompatible mice.


A technique for orthotopic liver transplantation in the rat.


Transplantation of kidneys containing primary malignant tumors.


Detection of H-2 antigens on the cells of the early mouse embryo.


The unusual fate of second skin grafts across an H(Tla) barrier.


Insurance perspectives for the kidney transplant recipient.


In vitro studies on respiratory and genital strains of IBR-IPV virus. I. Growth studies in cell and organ cultures.


Antimicrobial therapy.

Antimicrobial therapy.


Expanded roles for VA nurses.

Expanded roles for VA nurses.


Variable experiences in immunization of rats against Streptococcus mutans-associated dental caries.


Studies on the viability of Shigella flexneri. The effect of nutrient, dryness and relative humidity.


Operation Arrowhead (Alvar Nuñez Cabeza de Vaca).


Early use of x-ray by the military.

Early use of x-ray by the military.


Aetiology of Reye's syndrome.

Aetiology of Reye's syndrome.


G. McLoughlin.

G. McLoughlin.


H. P. Ozorio.

H. P. Ozorio.


P. W. McKeag.

P. W. McKeag.


J. Thomson.

J. Thomson.


A. A. Douglas.

A. A. Douglas.


Barbara M. Wilkinson.

Barbara M. Wilkinson.


Area differences in spontaneous abortion rates in South Wales and their relation to neural tube defect incidence. Data are presented from the South Wales Congenital Malformation Survey (92,982 births 1964-6 inclusive) showing that within areas in South Wales there exists an inverse relation between previous spontaneous abortion rate and the prevalence at birth of neural tube defect (anencephaly or spina bifida cystica or both). This relation is independent of social class, parity, and maternal age, and is not likely to be explained by area differences in accuracy of reporting previous spontaneous abortions.On the basis of these findings a hypothesis is advanced which proposes that the incidence of neural tube defects is uniform throughout South Wales and that the present substantial and relatively stable differences in area prevalence are controlled by small area differences in mortality of malformed embryos. This would seem to suggest that factors initiating the malformation are genetic and that any related environmental factors exert their effect on already abnormal fetuses by influencing, in one way or another, their capacity to survive.


Trigeminal neuralgia and dental malocclusions. Out of 39 patients with intractable trigeminal neuralgia seven have had continuing relief for over three years after dental treatment. Five out of six recent consecutive edentulous patients had immediate improvement. More radical treatment, such as ganglion injection or nerve root section, has been at least postponed.


Blast cells with monoclonal surface immunoglobulin in two cases of acute blast crisis supervening on chronic lymphocytic leukaemia. Acute blast crisis occurred in two patients with previously well-confirmed chronic lymphocytic leukaemia. The finding by direct immunofluorescence of membrane-bound monoclonal immunoglobulins on the surface of the blast cells showed that they were related to B cells in the same way as the proliferating lymphocytes in most patients with chronic lymphocytic leukaemia. In one patient the surface monoclonal IgM detected on both the lymphocytes and the blast cells had the same rheumatoid antibody activity, supporting the concept that the leukaemic cells found during the acute and chronic phases of the disease originated from the same clone.


Sir Stanford Cade.

Sir Stanford Cade.


J. L. Hansell.

J. L. Hansell.


R. G. Tuke.

R. G. Tuke.


Neoplasia--what are the prospects of immunological intervention?


Therapeutic screening to differentiate malaria from other tropical syndromes.


The effects of some trace metals on marine phytoplankton.


Phytoplankton ecology: a conceptual review based on eastern Gulf of Mexico research.


Inorganic nutrient uptake and deficiency in algae.


Placental metabolism in relation to toxicology.


Nosocomial infections.

Nosocomial infections.


Neonatal milk aspiration pneumonia--a possible additional use for continuous positive airway pressure.


Prolonged pediatric ventilatory assistance and related problems.


Environmental chemistry--an examination of available literature.


Auto-antibodies in rheumatoid arthritis.


The macrophage aggregation assay for cell-mediated immunity in man. Studies of patients with Hodgkin's disease and sarcoidosis.


John Waring Parker, M.D. First medical superintendent-South Carolina State Hospital.


Epilepsy in the dog--a comparative approach.


Chronic infection of the costal cartilages after thoracic surgical procedures.


Surgical progress-retrospection and prospection.


In memoriam. Sir Clement Price Thomas.

In memoriam. Sir Clement Price Thomas.


A medical classic: the care of the patient by Francis W. Peabody. Jama, 1927, 88: 877.


Milk sickness: a disease of the Middle West.


Revertants of an Escherichia coli K-12 strain with high sensitivity to radiations and chemicals.


Effect of rec mutations on the ultraviolet protecting and mutation-enhancing properties of the plasmid R-Utrecht in Salmonella typhimurium.


Reduced dimer excision in bacteria following near ultraviolet (365 nm) radiation.


Malaria in New York City. I. History of the disease from 1796 to 1903.


Phrenology in New York State.

Phrenology in New York State.


The structure of togaviruses.

The structure of togaviruses.


Need for monitoring vaccinated populations for immunity levels.


Progress in medical therapy of gallstones.


The treatment of silent gallstones.

The treatment of silent gallstones.


Sphincteroplasty (not sphincterotomy) in the treatment of biliary tract disease.


Retained common duct stones.

Retained common duct stones.


Primary sclerosing cholangitis: a disease revisited.


Prevention and repair of strictures of the extrahepatic bile ducts.


Carcinoma of the bile duct.

Carcinoma of the bile duct.


Sclerosing carcinoma of the hepatic bile ducts.


Pathogenesis of gallstones.

Pathogenesis of gallstones.


Criteria for levels of care evaluation under Medicare.


Proteases of Clostridium botulinum. 3. Isolation and characterization of proteases from Clostridium botulinum types A,B,C,D and F.


Mechanisms of suppression.

Mechanisms of suppression.


Necrotic enteritis of breeder ducks.

Necrotic enteritis of breeder ducks.


Surface immunoglobulin of circulating lymphocytes in chronic bovine diarrhea: abnormalities in cell populations and cell function.


Medicaid and Iowa physicians.

Medicaid and Iowa physicians.


Immunologic deficiency disease. Approach to diagnosis.


Malaria in New York City. II. End to the period of endemicity--1904 to 1939.


Yellow Fever in city of New York. Notes on epidemic of 1798.


Fred Jay Seaver 1877-1970.

Fred Jay Seaver 1877-1970.


Some recent advances in the management of anxiety.


A controlled trial of oxypertine in patients with anxiety.


A multicentre clinical trial of oxypertine in anxiety neurosis.


Measurement of hepatic blood flow in the rat. Trans-hepatic catheterization of the hepatic veins.


Biological availability and in vitro release from oral oxytetracycline and tetracycline preparations.


Cortical control of the superior colliculus in awake non-paralyzed cats.


Mechanism of the protective effects of prostaglandins E1 and F2 alpha in canine endotoxin shock.


Effects of clonidine and L-dopa on spontaneous and evoked splanchnic nerve discharges.


Serological grouping of Escherichia coli strains isolated from urine in urinary tract infections.


A histological study of liver lesions in leprosy.


Obituary: Professor Om Prakash.

Obituary: Professor Om Prakash.


In memoriam: Ronald Bramble Green C.B.E., M.A. (Dunelm), M.B., B.S. (Lond.), Hon.D.C.L. (Dunelm), F.R.C.S.


Reactions of rat megakaryocytes in mixed cell suspension.


The activity of different transfer factors introduced into the same plasmid-containing strain of Escherichia coli K12.


Computer assisted analysis of insulin response to glucose stimulus.


A new method for assessing inhibition of gingivitis by potential therapeutic agents.


Scanning electron microscopy of the root surface following instrumentation.


Reconstructive surgery of lower extremity injuries.


Brigadier J. Ferris Fuller, OBE, ED, GHDS.


Cancer genetics. II. Studies in humans. Problems in human studies.


Constancy of the UV sensitivity of E. coli during the cell cycle.


The intellectual relationship between Nietzsche and Freud.


The increase in the number of circulating megakaryocytes and blood platelets in rats after surgery.


Demonstration of spleen colonies on grafted spleens in the radiation chimera.


Ultrastructural methods for looking at frozen cells.


Health fairs and medical museums in Texas.


The changing face of Texas medicine.

The changing face of Texas medicine.


The multiple drug user.

The multiple drug user.


Surgical management of rheumatoid arthritis of the upper extremity.


Demonstration of bile canaliculi by an immunofluorescent staining technique.


Costello Memorial Lecture, 1972. The ages of radiology.


Analysis of gamma-camera imaging data by a small digital computer.


1-Aminoglycosides, a new class of specific inhibitors of glycosidases.


An affinity column for renin.

An affinity column for renin.


An inhibitor of host sigma-stimulated core enzyme activity that purifies with DNA-dependent RNA polymerase of E. coli following T4 phage infection.


Methods of measuring bile acids in bile and feces.


Hybridization of DNA modified by interaction with a metabolic fragment from S-(1,2-dichlorovinyl)-L-cysteine.


Preparation of two solid phase immunogens.


Transfer RNA: change of conformation upon aminoacylation determined by Raman spectroscopy.


Alterations in the control of glutamate uptake in mutants of Aspergillus nidulans.


Replication of bacteriophage M13 DNA in plasmolysed Escherichia coli cells.


A mutant of Escherichia coli with altered inducer specificity for the fad regulon.


Potassium fluxes, first indications of membrane damage in micro-organisms.


Molecular characterization of a stable Flac plasmid.


A history of water fluoridation.

A history of water fluoridation.


Idiopathic hematuria of childhood. Pathologic findings in the kidney in six patients.


Will consolidated clinical laboratories supplant individual hospital laboratories?


Studies on absorption kinetics of different brands of chloramphenicol.


Immunological studies in protein malnutrition I. Humoral and cell mediated immune response in protein deficient mice.


Effect of acute and chronic starvation on plaque forming cell response in mice.


Energy transfer from tryptophan residues to a fluorescent ATP analog, 1,N6-ethenoadenosine triphosphate, bound to H-meromyosin.


CD and fluorescence studies of tRNAPhe from baker's yeast.


Production of IgM and IgG antibodies specific for AMP in rabbits by immunization with AMP-E. coli conjugate.


Arousal response to electrical stimulation of the cerebral cortex in cats.


A comparison of some polymer-containing die materials.


A method of using resilient anchorages in complete denture construction.


Bridge prostheses for cleft-palate patients.


Outlining the denture-bearing area: an alternative material.


A survey of forensic pathology in England since 1945.


"The newborn, now or never".

"The newborn, now or never".


Intestinal stenosis and enterocyst formation as late complications of neonatal necrotizing enterocolitis.


Behavioral and fantasied indicators of avoidance of success in men and women.


Toward a third century of progress.

Toward a third century of progress.


Diabetes mellitus presenting as esophageal moniliasis.


An overview: Positive end expiratory pressure (PEEP).


Immunofluorescence in a case of Goodpasture's syndrome.


Lioresal in the treatment of spinal spasticity.


Results of international clinical trials with Lioresal.


Multiple sclerosis in the Shetlands, with an evaluation of Lioresal.


The treatment of spasticity in children.


Clinical trial of baclofen against placebo.


Reminiscences of arterial homografting, hypothermia and other surgical endeavors.


The use of tissue-matched meshed homografts in the treatment of massive burns.


Henry Swan, M.D.

Henry Swan, M.D.


Respirator-induced fluid shifts.

Respirator-induced fluid shifts.


Fine structure of the fetal-maternal area of exchange in the epitheliochorial and endotheliochorial types of placentation.


Iron-fortified bread. A long-term controlled therapeutic community-based experiment with ferrous sulphate-enriched flour.


Video scanner-analog computer system for semiautomatic analysis of routine echocardiograms.


François-Franck on experimental valvulotomy (1882).


Henry Alexander Davidson, 1905-1973.

Henry Alexander Davidson, 1905-1973.


Methyltestosterone with imipramine in men: conversion of depression to paranoid reaction.


Editorial: The development of paediatric anaesthesia and intensive care in Australia.


Amitriptyline in anxious-depressed outpatients: a controlled study.


Renal physiology in children.

Renal physiology in children.


The management of respiratory failure in infancy.


Anaesthesia for children with congenital heart disease.


Acute epiglottitis--management by intubation.


Letter: The first fatal case of chloroform anaesthesia in Australia.


Sir Edward Muir (1906-1973). President of the Royal College of Surgeons of England, 1972-1973.


Prolongation of renal allotransplant in the rat by antigen-antibody mixture.


Pandora's Box. Thoughts on health and illness in poetic literature.


Histocompatibility in organ transplantation.


Serum and secretory antibodies in patients with chronic bronchitis.


Erythrocytosis after renal transplantation. Its occurrence in two recipients of kidneys from the same cadaveric donor.


Screening for bacteriuria in pregnancy. A critical reappraisal.


Proceedings: Homologous nasal hump implant.


Proceedings: Repair of septal perforations with composite grafts.


Proceedings: Triple fractures of the mandible with flaring rami. Their treatment with lingual splints.


Proceedings: A serious cosmetic complications of the osteoplastic frontal flap.


Letter: Nasal hump implant.

Letter: Nasal hump implant.


Kenneth M. Brinkhous, MD, fifth chief editor.


Malignant lymphoid tumors of lymph nodes in the adult.


Agostino Bassi bicentennial (1773-1973).


A 4.5 mm. penetrating keratoplasty for leucoma adherens of 4.5 mm. or less.


Therapeutic penetrating keratoplasty in keratomalacia.


Growth and physiology of rickettsiae.

Growth and physiology of rickettsiae.


Experiments on refractive keratoplasty.

Experiments on refractive keratoplasty.


Advances in Streptomyces coelicolor genetics.


New donor-graft clamping block.

New donor-graft clamping block.


Obesity: another hazard for spina bifida children.


Scanning electron microscopic studies on the direct bonding system.


Neonatal necrotizing enterocolitis.

Neonatal necrotizing enterocolitis.


Patterns and clusters--multivariate approach for interpreting clinical chemistry results.


The growth of the AACC: 25 years.

The growth of the AACC: 25 years.


Toxicology and adverse effects of mineral imbalance.


Interaction of a hydrophobic fluorescent probe with mouse embryo fibroblasts.


Changes after immunization in the hybridization of mouse spleen RNA and reiterative DNA.


A clinical trial of broxyquinoline--brobenzoxalidine in childhood diarrhoea.


Dreams in group therapy: a review of the literature.


The group psychotherapy literature: 1972.


A tribute to S. S. Stevens.

A tribute to S. S. Stevens.


Significance of S. S. Steven's contribution to science.


Stevens as educator.

Stevens as educator.


S. S. Stevens: his impact on physiology.


Steven's operationism.

Steven's operationism.


Editorial: Woman power.

Editorial: Woman power.


Bullous pemphigoid: elution of in vivo-fixed antibody.


Prolonged survival of human skin xenografts on antithymocyte serum-treated mice: failure to produce verrucae by inoculation with extracts of human warts.


A reconsideration of the secretory function of the human endometrium.


Plasma volume in normal first pregnancy.


James Henry Dible, 29 October 1889--1 July 1971.


Tryptophan metabolism in acrodermatitis enteropathica.


Letter: Anterior pituitary function in a neonate with craniofacial dysraphia.


Depression in children referred to an educational diagnostic center: diagnosis and treatment. Preliminary report.


Letter: The issue of prophylaxis of neonatal group B streptococcal infections.


Immunologic defenses against cancer.

Immunologic defenses against cancer.


Transmission of group B streptococci among parturient women and their neonates.


Management of combined injury of the pancreas and upper urinary tract.


Living renal donor. Nephrectomy: evaluation of 135 cases.


Phenoxybenzamine in neurogenic bladder dysfunction. I. A theory of micturition.


Low mortality cystectomy in bladder cancer.


Changing patterns in marine biological exploration. Seventh Coppleson memorial lecture, 1972.


A new method of inhibition of lactation.


James Percival Ainslie.

James Percival Ainslie.


Letter: Points about viral chemotherapy.


Prevention of venous thromboembolism in surgical patients.


Possibilities for the evolution of the genetic code from a preceding form.


Genetic differences in conformational changes of albumin in the house mouse.


Platelet contractile regulation in an isometric system.


Does gonadotrophin-induced ovulation in mice cause malformations in the offspring?


Identification of skin in airborne particulate matter.


Abrogation of lymphocyte trapping by ascitic tumours.


New histone kinases in nuclei of rat tissues.


Elevated erythrocyte calcium in sickle cell disease.


Implications of the new age estimates of the early South African hominids.


The problem of compensation for antenatal injuries.


Location of hydrogen atoms in ADP by neutron powder profile refinement.


Suppression of mouse antibody producing spleen cells by various interferon preparations.


Slightly deleterious mutant substitutions in evolution.


Changes in the incorporation of different RNA precursors into the maternal liver during pregnancy.


A human B lymphocyte specific antigen.

A human B lymphocyte specific antigen.


Antitumour activity of iodine in acidic medium with calcium.


Forty years in the female pelvis. An unusual case of prolonged dystocia.


Twin pregnancy, complications and treatment.


Premarital pregnancy: a record linkage analysis.


Effects of social status and status inconsistency on morbidity for the poor and nonpoor: a binary variable multiple regression analysis.


Small intestinal biopsy.

Small intestinal biopsy.


Replication of Sindbis virus. 3. An electron microscopic study of virus maturation using the surface replica technique.


Role of T4 phage-directed protein in the establishment of resistance to T4 ghosts.


Editorial: An assessment of human cardiac transplantation.


Emiocytosis of B granules from saurian pancreatic islets perifused in vitro.


Thrombo-angiitis obliterans: a study of the vascular lesions leading to presenile spontaneous gangrene by Leo Buerger, M.D.: published, 1908 in the American Journal of the Medical Sciences.


Candida osteomyelitis. Report of a case.


Experience with the environmental temperature test in patients with peripheral arterial occlusive disease.


Pulmonary contusion. Pathogenesis and effect of various resuscitative measures.


The effect of acute autonomic denervation on pulmonary vascular resistance.


Hypothermic perfusion preservation of the isolated dog lung.


Carotid body resection. Controversy--confusion--conflict.


Effect of oxyphencyclimine HCl on basal gastric secretion of acid and pepsin in man.


Studies on the interaction of norepinephrine with some other drugs on the aortic smooth muscle of the rabbit.


Editorial: The radioimmunoassay of gastrin.


Computer-assisted programs in pediatrics.


Neuroleptanesthesia for neonates and infants.


Carl Waldemar Walter, M.D.

Carl Waldemar Walter, M.D.


Charles C. Edwards, M.D.

Charles C. Edwards, M.D.


Primary sclerosing cholangitis.

Primary sclerosing cholangitis.


Historical vignettes: Antoine-Laurent Lavoisier. (1743-1794).


Harry Grant-White. A peripatetic traveler.


Respiratory function tests for a clinician.


Proceedings: Cancer of the kidney--etiology, epidemiology, and pathology.


Proceedings: The Veterans Administration Cooperative Urological Research Group's studies of cancer of the prostate.


Proceedings: Sarcoma of the bladder and prostate in children. Rationale for the role of radiation therapy based on a review of the literature and a report of fourteen additional patients.


Lymphosarcoma and reticulum cell sarcoma in children. A retrospective study of 172 cases.


Nucleolar antigen specific for antinucleolar antibody in the sera of patients with systemic rheumatic disease.


Effect of glucose loading on the blood glucose level and histology of the principal islets in Channa punctatus.


Reappearance of cyclicity of vaginal smears in androgen-sterilized rats following thyroidectomy. During studies on the mechanism of hypersensitivity to gonadotropins of thyroidectomized rat ovary, results were obtained which suggest an increase in the endogenous luteinizing hormone (LH) release after thyroidectomy in androgen-sterilized  rats.  Female rats were injected subcutaneously with 1 mg of testosterone propionate dissolved in .05 ml of olive oil on Day 5 after birth.  At the age of 10-12 weeks, those animals which showed persistent vaginal cornification were thyroidectomized.  Within 1-2 days after thyroidectomy, the thyroidectomized rats exhibited leukocytic and epithelial vaginal smears for 2-6 days.  Irregular cyclicity with the pattern of 2-6 days diestrus and 3-10 days estrus persisted for 1 month.  Histological examination revealed that the corpora lutea were intermingled with a number of cystic follicles in the ovaries of the androgen-sterilized and throidectomized rats while the ovaries of androgen-sterilized controls had vesicular  follicles but were devoid of corpora lutea.  The results indicate a rapid enhancement in the LH release in androgen-sterilized rats following thyroidectomy.


Continuous cultivation of microorganisms. A review.


Histone-induced changes of protein synthesis in Escherichia coli. II. Effect of histone on alkaline phosphatase synthesis.


Modulation of reflex contraction of urinary bladder by diencephalic and telencephalic centres.


The Society of Critical Care Medicine, its history and its destiny.


Laceration of the flexor pollicis longus tendon: delayed repair by advancement, free graft or direct suture. A clinical and experimental study.


Evaluation of tracheal tube cuff designs.


Tennis elbow.

Tennis elbow.


An unusual gastrocnemius muscle syndrome. Case report.


A double-blind clinical trial of prophylactic antibiotics in hip fractures.


A universal device for positive end-expiratory pressure (PEEP).


Editorial: ADHA: Fiftieth Anniversary.

Editorial: ADHA: Fiftieth Anniversary.


Johansen appointed Editor of Journal of Dental Education.


Trimethoprim-sulfamethoxazole: in vitro microbiological aspects.


Quantification of the antibacterial action of trimethoprim alone and in combination with sulfonamides by bacterial growth kinetics.


Synergistic activity of trimethoprim-sulfamethoxazole on gram-negative bacilli: observations in vitro and in vivo.


Nature of the bacterial action of sulfonamides and trimethoprim, alone and in combination.


Analysis of in vitro antibacterial activities of the combination of trimethoprim and sulfamethoxazole on clinical isolates in Japan.


The susceptibility of Serratia marcescens to sulfamethoxazole, trimethoprim, and trimethoprim-sulfamethoxazole.


Trimethoprim-sulfamethoxazole. Comparison of synergistic combinations.


Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man.


Trimethoprim-sulfamethoxazole in children: pharmacokinetics and clinical studies.