Oliver Wendell Holmes. "Miscuit utile dulci". The life of Oliver Wendell Holmes was selected as the subject for a lecture in the 1974 History of Medicine series at Yale University School of Medicine because, as the Latin subtitle of the essay suggests, he represents a fortunate and uncommon, but by no means unique, synthesis of the practical and aesthetic, of science and the humanities. An attempt has been made by the lecturer, employing frequent, but brief, excerpts from the works of several disinguished biographers as well as Doctor Holmes' own lectures, medical papers, essays and poems to delineate the elite heritage and the events that led this complex person transiently into the sudy of law, the profession in which his older son reached the pinnacle of the U.S. Supreme Court, and finally into medicine where a short period of private practice was followed by more than three decades of distinguished teaching is anatomy. His lifetime (1809-1894) spanned most of the nineteenth century, in the literary hisory of which he played a significant role. His writings reveal a remarkable, and sometimes prophetic, appreciation of the impact that burgeoning science and evolving social pressures and changes would have on the teaching and practice of medicine in the future-our present.


Medical reviews. Coronaviruses.

Medical reviews. Coronaviruses.


Studies of septation and separation in a mutant of Salmonella typhimurium.


Morphology and growth pattern of a rod-negative envB mutant of Escherichia coli K12.


Eastern State: America's oldest public hospital.


Editorial: Par'e.

Editorial: Par'e.


Transplantation of the lung--retrospect and prospect.


Problems in the management of human lung transplant patients.


Transplantation of the lung: a symposium. Rejection lung syndrome.


Ventilation perfusion relationships between transplanted and emphysematous lungs.


Transplantation of the lung: a symposium. Oxygen transport in the transport patient.


A new approach to gastric resection with jejunal replacement.


Denture stomatitis. Occurrence and distribution of fungi.


Dental holographic interferometry in vivo utilizing a ruby laser system II. Clinical applications.


Effect of synthetic LH-RH on serum LH and FSH levels in patients with second grade amenorrhea.


Hereditary nephropathy with hearing loss. "Alport's syndrome".


Editorial: Clinical and ill-considered demonstrations.


Pyloric atresia.

Pyloric atresia.


8-10 year follow-up of 84 children treated for behavioral disorder in rural Vermont.


Haemophilus aphrophilus septicaemia.

Haemophilus aphrophilus septicaemia.


Isolation and purification of deoxyribonucleic acid from mycobacteria.


Indirect haemagglutination for demonstration of antibodies to Aspergillus fumigatus.


The effect of Eperythrozoon coccoides infection on the number of plaque forming cells in mice.


A comparison of psychotic and alcoholic psychiatric hospital patients on the Rosenzweig picture frustration study.


A single daily dose of a sustained release form of amitriptyline in depressive illness.


Practolol-propranolol. A comparison of antihypertensive effect.


Lithium treatment of psychotic children and adolescents. A controlled clinical trial.


The nomenclature of the arterial pole of the embryonic heart. I. Review of the literature up to 1750.


The nomenclature of the arterial pole of the embryonic heart. II. Review of the literature from 1750-1890.


The nomenclature of the arterial pole of the embryonic heart. III. Review of the literature from 1890-1973.


A simple and inexpensive method of slicing whole, small animals.


The nomenclature of the arterial pole of the embryonic heart. IV. Discussion and conclusion.


The thermistor as a thermode fed with direct current for the hypothalamic heating.


Legal and social aspects of drug abuse in historical perspective. Is the drug abuser a patient or a criminal?


Mucoid enteritis in the rabbit associated with E. Coli. Changes in the carbohydrate metabolism.


Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.


Toward an understanding of human error in the "lymphomas".


Effect of hypothyroidism on parasitemia and survival in rodent malaria.


Acquired factor VIII inhibitor in a patient with malignant lymphoma.


The American Journal of Roentgenology Radium Therapy and Nuclear Medicine.


Lymphoceles following renal transplantation.


The early anesthesia chart in Canada.

The early anesthesia chart in Canada.


Perfusates for preservation of kidneys, livers and hearts.


Activity of murein hydrolases and membrane synthesis in synchronized Escherichia coli B/r.


Wall and membrane growth in bacilli and their mutants.


Cell division and permeability of unbalanced envelope mutants of Escherichia coli K12.


By-pass operations in the treatment of obesity.


Clinical and pathophysiological aspects of the asplenic state.


Subacromial betamethasone therapy. II. Subacromial betamethasone and methylprednisolone injections in treatment of frozen shoulder and supra spinam tendinitis. A comparative trial.


The estimation of the size of the spleen by radiological methods. A comparative radiographic, gamma imaging and ultrasonic study.


John Ray: indefatigable student of nature.


The fine structure of membranes and intercellular communication in insects.


Guinea pig lymphotoxin. II. Study of its mechanism of action. Its differentiation from migration inhibitory factor and interferon.


Giulio Cesare Pupilli (1893-1973)

Giulio Cesare Pupilli (1893-1973)


The specific antigen(s) of cells in culture.


T and B membrane markers on blast cells in 69 patients with acute lymphoblastic leukemia.


Award of the Gilruth Prize to Donalt Thomas Oxer, D.V.Sc., F.A.C.V.Sc.


Morphofunctional differentiation in the liver. III. Interaction between cortisone and reticuloendothelial active agents on DNA synthesis.


Presynaptic regulation of catecholamine release.


Diazepam as an adjunct in propanidid anaesthesia for abortion.


Functional residual capacity during anaesthesia. I: Methodology. The helium dilution technique for the measurement of functional residual capacity (FRC) is reviewed with special reference to anaesthesia. A modification is described which permits measurements to be made during intermittent positive pressure ventilation. This modification causes minimal interference with the circuit as it is used for spontaneous respiration. The measuring circuit may be alternated with an open circuit without disturbance of the pattern of breathing (spontaneous or artificial). Potential errors in the measurement of FRC during anaesthesia are considered and assessment of linearity, reproducibility and accuracy is described.


Functional residual capacity during anaesthesia. II. Spontaneous respiration. Functional residual capacity has been measured by helium dilution in 26 spontaneously breathing patients before and immediately after anaesthesia, which was induced with thiopentone and maintained with halothane. The mean reduction was 390 ml (16.1% or pre-induction value) and the change was highly significant (P less than 0.001). The decrease in FRC correlated with age (r equals 0.41: P less than 0.005) and less (P less than 0.001). The decrease in FRC correlated with age (r equals 0.41; P less than 0.005) and less satisfactorily with the weight/height ratio (r equals 0.31; P less than 0.05) which itself correlated with age. Inspired oxygen concentration, expiratory reserve volume and the presence of phasic expiratory muscle activity bore no significant relationship to the decrease in FRC. There was no evidence of any progressive change in FRC between 6 and 20 min after the induction of anaesthesia.


Functional residual capacity during anaesthesia III: Artificial ventilation. The helium dilution technique has been used to measure the FRC of 13 patients before and during anaesthesia with paralysis and artificial ventilation, and also in 5 conscious subjects during spontaneous and artificial ventilation without paralysis. After induction of anaesthesia the mean reduction in FRC was 297 ml or 15.4% of the preoperative value and the change was highly significant (P is smaller than 0.005). In the conscious subjects, the FRC was reduced in every case during artificial ventilation by a mean value of 99 ml or 4.1% of original value. This change was also significant. The anaesthetized patients breathed 35% oxygen before and during anaesthesia. The (A-a) PO2 difference increased from a mean value of 49.1 mm Hg before anaesthesia to a mean of 79.7 mm Hg during anaesthesia, the change being highly significant (P is smaller than 0.001). Individual changes correlated with the reduction in FRC (P is smaller than 0.005).


Survival after pulmonary haemorrhage in idiopathic respiratory distress syndrome of the newborn. Pulmonary haemorrhage is a commonly fatal condition which may complicate mechanical ventilation of the premature neonate with the respiratory distress syndrome (RDS). The survival of one such patient is recorded.


A comparative trial of bromhexine HCl and oxytetracycline in acute and chronic bronchitis.


Subacute administration of pentaerythritoltetranicotinate (Perycit) to man.


Nitrous oxide/oxygen in the London Ambulance Service.


Effect of beta-pyridylcarbinol (Ronicol) on the myocardial contractility in normal persons.


A trial of polyglycolic acid and chromic catgut sutures in episiotomy repair.


Plasma triglycerides in Belgian postmen.


A new anti-trichomonal agent.

A new anti-trichomonal agent.


Parenteral cephalexin in a general surgical unit.


Clindamycin in conjunction with surgery of the chronic suppurative ear.


Anxiety neurosis in general practice.

Anxiety neurosis in general practice.


The use of the life aid cardiopulmonary resuscitator--preliminary report.


Trimethoprim/sulphamethoxazole and tetracycline in lower respiratory tract infections.


In vitro malignant transformation of cells by chemical carcinogens.


Three decades of hemodialysis.

Three decades of hemodialysis.


Recent developments in European dialysis.


Clinical management of chronic dialysis patients.


Clinical cytogenetics. Introduction.

Clinical cytogenetics. Introduction.


Origins of the receptor theory of drug action.


Science, politics and spontaneous generation in nineteenth-century France: the Pasteur-Pouchet debate.


T he disease of masturbation: values and the concept of disease.


The cesarean operation in Alta California during the Franciscan Mission Period (1769-1833).


The intriguing nucleus of Deiters. Notes on an eponym.


The National Organ Matching and Distribution Service.


Studies of general practice demand, need, quality.


The development of maternity services in Bristol.


The effect of sul on permissiveness of Plkc in strain B of Escherichia coli.


Control of RNA synthesis in yeast.

Control of RNA synthesis in yeast.


Cellular requirements for the expression of IgM. Immunological memory in vitro.


Murine spleen leukocytes as an inhibitable target cell system for human MIF.


Evidence of immunological activity in heterotropic autotransplanted splenic tissue in DBA/2 mice.


Immunocytology of cultured IgM-forming cells of mouse. II. Purification of phagocytic cell factor and its role in antibody formation.


A rapid method for measuring the production of human migration inhibitory factor (MIF).


The effect of specific anti-rat thymocyte serum on cell-mediated tumor immunity and other lymphocyte functions.


Migration inhibitory factor (MIF) production by skin fibroblast cultures from patients with severe combined immunodeficiency.


In memoriam. J. R. Frey, M.D. (1912-1974).


Fluorescence-activated cell sorting of human T and B lymphocytes. II. Identification of the cell type responsible for interferon production and cell proliferation in response to mitogens.


Encapsulation of foreign materials experimentally introduced into the freshwater snail Lymnaea stagnalis. An electron microscopic and autoradiographic study.


Longitudinal malaria studies in rural north-east Thailand: demographic and temporal variables of infection. A prospective longitudinal study of malaria incidence was carried out in randomly selected samples of the population in the villages of Bu Phram and Tablan, north-east Thailand. During the 10-month study period 46% of the 252 persons followed up experienced a falciparum parasitaemia, and 23% a vivax parasitaemia. The peak of the cases occurred during a 10-week period from late May to the end of July, with transmission apparently continuing, at lower levels, throughout the remainder of the study period. Falciparum infection rates were higher for residents of Bu Pham; vivax infection rates were the same in both villages. Certain indices declined with age in Bu Phram but not in Tablan residents. Parasite rates were higher for males than for females. Age-specific rates did not vary predictably. Infection of children aged less than one year was rare.


Development and decline of antiplasmodial indirect fluorescent antibodies in mice infected with Plasmodium berghei (NK65) and treated with drugs. Malaria parasites in mice present a simplified rodent model for the immunological study of malaria. Experiments have been performed to determine the pattern and persistence of malaria antibody as detected by the indirect fluorescent antibody (IFA) test utilizing specific antimouse IgM and IgG conjugates. The antibody levels in mice inoculated with Plasmodium berghei and treated with antimalarial drugs were traced after complete elimination of the parasites from the host. Within 1-2 weeks after inoculation, both specific IgM and IgG reached peak levels, which thereafter declined rapidly. The results suggest that a high IFA titre may be taken as an indication of recent parasitaemia when the parasites are absent from the host. The protective role of the specific immunoglobulin was not found in the cured animals at the time when the animals showed a high IFA titer. It seems that the detected IFA may not reflect protective immunity against reinfection with malaria parasites.


A comparison of bromcresol green and immunoprecipitation methods for the determination of serum albumin.


Specificity of the indirect haemagglutination test with Plasmodium falciparum test cells. Comparison of indirect haemagglutination and fluorescent antibody tests on African sera. The specificity of the indirect haemagglutination (IHA) test with Plasmodium falciparum placental antigen-sensitized test cells was examined with sera from healthy blood donors and from patients with diseases other than malaria. Only 1 nonspecific antibody reaction was seen in more than 700 tests. A comparison of IHA titres and indirect fluorescent antibody (IFA) titres with IgG and IgM conjugates on 503 sera from inhabitants of Mto Wa Mbu in Tanzania showed in successive age groups an increasing number of seropositive reactors with both tests. The increase in the proportion of positive reactions and in the mean titre levels started earlier but was more gradual in the IFA test than in the IHA test. Parasite carriers had higher antibody levels than people without an apparent parasitaemia. Parasite carriers in the younger age groups especially were more frequently seronegative in the IHA test than in the IFA test with anti-IgG conjugates. The reactivity of the IHA test with P. falciparum (Palo Alto/Aotus) antigen was higher than that with P. falciparum placental antigen and was thus closer to that of the IFA test with IgG conjugates.


Peripheral blood T- and B-lymphocytes in patients with lymphoma and acute leukemia.


Management of premature rupture of the membranes.


National Library of Medicine fact sheet.


Combined immune deficiency, autoantibody formation, and mucocutaneous candidiasis.


Abnormal progression of labor (dystocia).


A transient defect in leukocytic bactericidal capacity.


Industrial research in the quest for new medicines.


Patterns of some diseases transmissible from animals to man--a review.


Histamine content of the nematode, Caenorhabditis elegans.


Anatomical considerations for the stereotaxic longitudinal hippocampectomy.


Fat embolism.

Fat embolism.


Some medical aspects of community child health.


Sinemet.

Sinemet.


Single-dose treatment of vaginal trichomoniasis with tinidazole.


Arthur Jores, in appreciation.

Arthur Jores, in appreciation.


The foundation meeting of the International Society for Biological Rhythms. Ronneby, Sweden, August 1937.


Chronobiology and the clinical psychiatrist: the current position.


Circadian urinary rhythms in rats with renal grafts.


Our colleague, the Minister.

Our colleague, the Minister.


Effect of reconstitution conditions on the structure of Escherichia coli 30-S ribosomol-subunit components.


Involvement of DNA polymerases I and III in the replication of bacteriophage M-13.


Regulatory behavior of monomeric enzymes. 2. A wheat-germ hexokinase as a mnemonical enzyme.


Yeast phenylalanyl-tRNA synthetase.  Stoichiometry of the phenylalanyl adenylate-enzyme complex and transfer of phenylalanine from this complex to tRNA-PHE.


Relations between structure and function in cytoplasmic membrane vesicles isolated from an Escherichia coli fatty-acid auxotroph. High-angle x-ray diffraction, freeze-etch electron microscopy and transport studies.


New inhibitors of FNA synthesis in vitro isolated from Escherichia coli.


The influence of 6-M urea on 30-S ribosomes of Escherichia coli.


Fecal flora and cecal weights in mice given validamycin A.


The state of organized family planning programs in the United States, 1973. Although by June 30, 1973 an estimated 5.2 million low-and marginal-income women received family planning services, more than 3.7 million lacked such services.  In 1973 3250 agencies provided services compared to 1399 in 1968.  The number of patients served per agency providing family planning services grew by 2/3 from 1969 to 1973, serving an average of 609 patients in 1969 and 989 in 1973.  85% of these patients served were from low or marginal income levels.  Patients in the programs used methods that were more effective than those used prior to the program, and than those used by counterparts in the general population.  97% of the patients received medical services in addition to contraception.  75% of patients remained active by the beginning of the second year after enrollment in the program, 40% by the third year, and 30% by the fourth year.


Alan F. Guttmacher, 1898-1974.

Alan F. Guttmacher, 1898-1974.


Positive controls of the test for sterility.


Allergic contact dermatitis to virginiamycin. False cross-sensitivity with pristinamycin.


Immunofluorescent procedures for mycoplasma identification.


On 8-hydroxyquinoline-zinc oxide incompatibility.


Quassinoid Bitter Principles.

Quassinoid Bitter Principles.


The Chemistry of Biflavanoid Compounds.

The Chemistry of Biflavanoid Compounds.


International reference preparation for human serum IgG, IgA, IgM.


Binding of epsilon-DNP-L-lysine exceeding two moles by purified chicken IgG anti-DNP antibody.


Inheritance of susceptibility to Friend mouse leukemia virus. XII. Effects of the Fv-1 locus.


Facilitation and inhibition of b16 melanoma by BCG in vivo and by lymphoid cells from bcg-treated mice in vitro.


Sensitization to tumour-associated antigens in human breast carcinoma.


The incidence of lung tumours in c57bl mice exposed to cigarette smoke: air mixtures for prolonged periods.


Comparative chemical analysis of Indian bidi and american cigarette smoke.


Lipid analysis of cell nuclei in young and old ehrlich ascites tumors.


Immunopathologic changes in patients with cutaneous malignant melanoma following intratumoral inoculation BCG: correlation with cell-mediated immunity.


Treatment of Kaposi's sarcoma by combination of actinomycin-D, vincristine and imidazole carboxamide (nsc-45388): results of a randomized clinical trial.


Effect of anti-embryo immunization on methylcholanthrene-induced sarcoma growth in BALB/c mice.


Effects of the administration of B663 [G 30 320, Lamprene, clofazimine (Geigy)] on three groups of lepromatous and borderline of leprosy.


A light and electron microscopic study of peripheral nerves in an armadillo with disseminated leprosy.


Minimum inhibitory and bactericidal dosages of rifampici against Mycobacterium leprae in the mouse foot pad: relationship to serum rifampicin concentrations.


On the etiology of cat leprosy.

On the etiology of cat leprosy.


A new hypothesis about the pathogenesis of chronic glomerulonephritis.


Changes in resistance of the bacterial flora among patients seen at the Ist department of surgery of the Szeged University during the past 5 years.


Bumetanide, a new diuretic.

Bumetanide, a new diuretic.


Diagnosis of urinary tract disorders in congenital spinal lesions.


On the pathogenesis of the so-called primary pyelonephritis.


Study of lesions in reimplanted kidneys preserved by hypothermic storage and perfusion with solution of the extracellular type.


Changes in the anterior nasal spine and the alveolar process of the macillae in leprosy a clinical examination. A brief review is presented of the Danish medieval skeletons with leprosy changes, particularly in the skulls, where the pathologic specific changes found are termed facies leprosa. The clinical aspect of facies leprosa is termed Bergen Syndrome I (nasal leprosy) and Bergen Syndrome II (the leprogenic changes of the alveolar process of the maxilla superior with loosening and/or loss of the frontal incisors). An account is given of the interim result of a clinical examination of 333 inpatients at the Prapradaeng Leprosarium in Bangkok, Thailand. In the group of 258 patients with lepromatous leprosy, 62.4% presented Bergen Syndrome I and 16.3% Bergen Syndrome II. These proportions differ clearly from the corresponding ratio found in the Danish medieval skulls.


Dublin University Biological Association 1874-1974 and Dublin University Medic-Chirurgical Society? 1867-?


Letter: Lepromin nomenclature.

Letter: Lepromin nomenclature.


The amnestic value of diazepam at forceps delivery. A preliminary report.


Curettage by the "Vabra" suction curette as an outpatient procedure.


Bacterial excretion rates in the diagnosis of urinary tract infections.


Leprosy of the nose clinical reassessment.


Lepromin retesting as a factor of lepromin test positivation.


Treatment of Parkinson's Disease with levodopa and amantadine used as single drugs and in combined therapy.


An extended clinical trial to compare levodopa and amantadine used as single drugs with both drugs used incombination in Parkinson's Disease.


Controlled long-term therapy of leprosy with B663 (lamprene, clofazimine) compared with DDS.


Obituary: Reynaldo Quagliato, M.D. 1908-1973.


Ernest Muir, C.M.G., C.I.E., M.D. (Edin,), F.R.C.S., LL.D. 1880-1974.


Obituaries: William Hugh Feldman, D.V.M.,M.S. 1892-1974.


Letter: polar concept in leprosy.

Letter: polar concept in leprosy.


Contraction stage and formation of the distance sex bivalent in Oedionychina (Coleoptera, Alticidae).


Health protection for the dentist--working in the mouth.


Obituary. Preben C. A. von Magnus. 25 February 1912-9 August 1973.


Kinetics of thermal death and prediction of the stabilities of freeze-dried streptomycin-dependent live Shigella vaccines.


Toxicology information--retrieval and dissemination at the Toxicology Information Response Center.


Purification and preliminary characterization of aspartate aminotransferase from yeast.


Some biophysical properties of virus present in tissue cultures infected with the nuclear polyhedrosis virus of Trichoplusia ni.


Criteria for subtyping poor prognosis schizophrenia: a numerical model for differentiating paranoid from non-paranoid schizophrenia.


Brigadier H. L. Glyn Hughes.

Brigadier H. L. Glyn Hughes.


The Editor: Metro A. Ogryzlo.

The Editor: Metro A. Ogryzlo.


Uricosuric effect of glyceryl guaiacolate.


Dr. David Lewis Phares: member first Mississippi State Board of Health.


Preliminary clinical study of acupuncture in rheumatoid arthritis.


Edward A. Dunlop lecture. Cell biology and the repair of articular cartilage.


Report of the Council on Medical Service: "Medicare/Medicaid amendments.


Studies of complement components and renal histology in patients with dense intramembranous deposits following renal transplantation.


The School of Nursing; University Hospital of the West Indies. A historical review.


A case in point.

A case in point.


Biochemical and histological effects of 1,25 dihydroxycholecalciferol (1,25-DHCC) in the osteomalacia of chronic and failure.


Mechanism of action of antitumor agents on bacteria.  I. Genetic studies.


Heart preservation with metabolic inhibitor, hypothermia, and hyperbaric oxygenation. The effect of metabolic inhibitor, hypothermia (4 degrees C) and hyperbaric oxygenation (3 atm) on prolonging survival of the canine anoxic heart has been evaluated. Donor hearts were obtained from small mongrel dogs by giving the pre-cooled perfusate of 2 per cent magnesium sulfate (MgSO4), 5 per cent low molecular weight dextran (LMWD) and 2 per cent glucose into the right atrium. Excised hearts were kept at 4 degrees C in a hyperbaric chamber pressurized to 3 atm. After 18 to 48 hours the preserved hearts were transplanted to the neck of recipients by the methods of Marcus. The viability of the preserved hearts were evaluated with functional, biochemical and histologic parameters. Of 29 hearts preserved for 18 to 36 hours, 27 hearts returned to a strong coordinated beat and could maintain function for over 4 hours. Of 5 hearts preserved for 48 hours, 4 showed a coordinated ventricular beat, however, failed to maintain cardiac work over 4 hours. The hearts with 18 to 36 hours storage showed no significant abnormalities on myocardial metabolism and morphology as compared to the control group of the immediately transplanted hearts. The protective action of magnesium is probably related to  a number of factors, including metabolic depression and stabilizing effect on membrane permeability of cells to potassium, which would tend to maintain a more normal membrane potential and sub-cellular particles. These studies indicate that viability of the mammalian anoxic hearts can be extended to 36 hours by the combined use of metabolic blockade, hypothermia and hyperbaria suggesting a practical approach to procurement and preservation of cadaver organs.


A descriptive theory of cell migration on surfaces.


The origin of gingival fluid.

The origin of gingival fluid.


Yeast fatty acid synthetase: a proposed binding site for coenzyme A with consequences for chain initiation and chain termination.


Professor D.P. Goldberg. Professor of Psychiatry at Withington Hospital.


Ultrastructural changes in the anterior pituitary gland of rabbits after the administration of synthetic LH-RH.


Cyclocryotherapy.

Cyclocryotherapy.


Senile entropion.

Senile entropion.


Surgical repair of cyclodialysis induced hypotony.


Thermokeratoplasty.

Thermokeratoplasty.


The cause of irreversible mydriasis following keratoplasty in keratoconus: a preliminary report.


Experimental study on the effect of thiamine drivative upon the kanamycin ototoxicity.


Diazepan (Valium) compared with other premedications in tonsillectomy, nasal septum correction and endoscopy under local anaesthesia.


The relation of bioavailability to the dissolution rate of experimentally produced digoxin tablets.


Infection and severe diabetic metabolic decompensation.


Digital ischaemia and malignant disease.


The medical Highmore family and their books.


Rieter's disease. Hans Conrad Reiter (1881-1969).


Results of preliminary investigations of fecal chloride elimination in infectious diarrheas in children aged up to two years with the use of chlorotrex.


Rate of production of volatile fatty acids in the rumen of milking cows.


The pool concept in food iron absorption and some of its implications.


Recent studies of the copper-molybdenum antagonism.


Recent studies of antagonistic interactions in the aetiology of trace element deficiency and excess.


The newer essential trace elements, chromium, tin, nickel, vanadium and silicon.


The nutritional and metabollic roles of selenium and vitamin E.


The delegate.

The delegate.


Letter: References on measurement of motor skill acquisition.


The use of enzymology in pharmacological and toxicological investigations*.


Carcinogenicity and structure in polycyclic hydrocarbons.


Recent advances in the synthesis of nitriles.


Linear free energy relationships and biological action.


The metabolism and biological actions of coumarins.


Immunological deficiencies induced by some hydrazone derivatives of rifamycin SV.


Ion exchange chromatography for quantitative analysis of radioactive histamine metabolites in human urine.


Selection of antimicrobial therapy in serious bacterial infections.


Treatment of venereal diseases. II. Syphilis.


Antimicrobial therapy of infections due to anaerobic bacteria.


Drug treatment of the systemic mycoses.

Drug treatment of the systemic mycoses.


Interstellar molecules.

Interstellar molecules.


Chemistry of the moon.

Chemistry of the moon.


Advances in inorganic geochemistry.

Advances in inorganic geochemistry.


Carbon chemistry of the Apollo lunar samples.


Studies on the chemotherapy of malaria. (III). Treatment of falciparum malaria in the Gambia, with BRL 50216 (4,6-diamino-(3, 4-dichlorobenzyloxy)-1,2-dihydro-2 2-dimethyl-1,3,5-triazine hydrochloride) alone and in combination with sulphonamides,.


Medical care in Tsarist Russia.

Medical care in Tsarist Russia.


Two cases of Trypanosoma (Herpetosoma) species infection of man in India.


Occurrence and association of amyloid with diseases in birds and mammals including man: A review.


Letter: An acute attack of quartan malaria in a leprosy patient being treated with diaminodiphenylsulphone.


Equine anti-human lymphocyte globulin III. Some immunochemical properties and in vitro assays of ALG and its subfractions.


Letter: An immediate intradermal reaction to leishmanial antigen in human cutaneous leishmaniasis.


Obituary: Professor William H. A. Taliaferro, 1895-1973.


Malabsorption in Africa.

Malabsorption in Africa.


The prevalence of antibodies to Dirofilaria immitis in Aboriginal and Caucasian Australians.


Experimentally dirofilariases in macaques. Susceptibility and host responses to Dirofilaria immitis, the dog heartworm.


Blood transfusion induced malaria in Iran.


Contagious skin necrosis of Somali camels associated with Streptococcus agalactiae.


On certain aspects of thyrotoxicosis and thyroid carcinoma.


Inflammation, prostaglandins and aspirin-like drugs.


Reflections on rehabilitation.

Reflections on rehabilitation.


Lettsom's heritage. Current practice in physical medicine.


Lettsom and the Roual Sea Bathing Hospital.


The character of Erasmus Wilson.

The character of Erasmus Wilson.


Tuberculosis since Lettsom.

Tuberculosis since Lettsom.


Suicide.

Suicide.


A congenital adenomatoid malformation of the lungs in a calf.


Occurrence of Cryptococcus neoformans in pigeon excreta in Enugu (Nigeria).


Thyroid nodules and thyroid cancer.

Thyroid nodules and thyroid cancer. A review of clinical and laboratory features of thyroid cancer, designed to help in a more precise selection of patients for operation, showed that factors contributing to a high index of suspicion of cancer include previous exposure to low doses of radiation, the presence of a firm, solitary thyroid nodule clearly different from the rest of the gland, a young patient, nodules that are "cold" on scan with radioiodine, and nodules that fail to regress after an adequate trial of thyroxine therapy. Factors contributing to a low index of suspicion of thyroid cancer include soft or cystic lesions, multinodular goiters, nodules that are "hot" on (131) I scan, and those that regress during thyroxine treatment. When these factors are used to select patients for surgical operation, about 30 percent are found to have thyroid cancer. Until more precise methods for preoperative diagnosis are established, it is suggested that this type of clinical selection may be very helpful in the management of patients with thyroid nodules or nontoxic goiter.


Urinary tract infections in children. Part I-- Young girls with non-refluxing ureters. This paper is the study of 144 girls with histories of urinary tract infection followed at the Stanford Medical Center who were found to be free of ureterovesical reflux. The mean age at onset of infection for the entire group was about four years and ranged from the first few months of life to age 10. Ninety-two percent of the 505 infection episodes in these children presented with symptoms referable to the lower tract, and bacterial localization studies confirmed that 85 percent of the infections were limited to the bladder. Escherichia coli was the most common organism isolated and most infections were caused by a pure culture of a single bacteria. In only two of the 144 patients studied was there any evidence of upper tract damage related to infection. The possibility that these patients had reflux at an earlier age could not be discounted. In response to short-term antibacterial therapy in 66 of the patients followed closely for an average of 40 months each, 20 percent of the patients had no further infections and 80 percent went on to recurrence. With each succeeding treatment an additional 20 percent of the patients were "cured," but the remainder experienced recurrent infections during the follow-up. This reinfection pattern supports the use of long-term antibacterial prophylaxis in all girls who have more than three or four recurrences of infections. Urethral dilation appeared to have no value in reducing the reinfection rate. While it appears that in the absence of ureterovesical reflux few, if any, of these children will go on to develop upper tract damage, long-term prophylactic suppressive medication can clearly be justified on the grounds of reducing patient morbidity.


Bacteriology of the gut and its clinical implications. The bacteriology of the gastrointestinal tract is rapidly changing in laboratory techniques and clinical correlations. The flora is found to be very complex, predominantly anaerobic, and importantly dependent on diet. An etiologic role for colon bacteria in colon cancer is suggested by correlations between epidemiologic data and prevalent dietary patterns and stool culture findings. Cultures from aspiration pneumonia, subphrenic abscess, and other intra-abdominal sepsis all yield anaerobes, and for best results antibiotic therapy should combat them as well as aerobes.


Editorial: Human gut microecology.

Editorial: Human gut microecology.


Editorial: The fascinations and frustrations of diabetes mellitus.


Malignant lymphoma in Ghana--Part I: A review of surgical material at the Korle Bu Teaching Hospital from 1966 to 1971.


Post-nephrectomic ureteral lesions. (An experimental kidney transplantation study).


Experimental pancreas transplantation.

Experimental pancreas transplantation.


Surgery in ancient Egypt.

Surgery in ancient Egypt.


Innervation of the autotransplanted lung. Experimental study.


A comparative study of N 7001 (Metrisil) and imipramine on a series of depressive patients.


Regional cerebral blood flow related to psychiatric symptoms in dementia with onset in the presenile period.


Rheology of pharmaceutical and cosmetic semisolids.


Radiopharmaceuticals.

Radiopharmaceuticals.


Rectal administration of drugs.

Rectal administration of drugs.


Determinaton of thermodynamics of functional groups in solutions of drug molecules.


Effect of halogenated anesthetics on liver metabolism and the immune response.


A cold but heart-warming experience.

A cold but heart-warming experience.


Marriage and fertility in postfamine Ireland: a multivariate analysis.


The daily problems in the intensive care unit.


A history of neurology in Alabama.

A history of neurology in Alabama.


Iniencephalus with ectopic lungs.

Iniencephalus with ectopic lungs.


Studies of blood clotting system during intravenous general anaesthesia with althesin.


Spirometric values following operations on lung tissue.


Clinical observations on intravenous anaesthesia with Althesin.


Respiratory problems after operations in extracorporeal circulation.


Gasometric values following operations on lung tissue.


Facial and oral form in sibs of children with cleft lip with or without cleft palate.


Equivalent responsiveness to native levan by the Biozzi AB/H and AB/L lines of mice.


Genetically controlled idiotype expression in inbred mice.


Escherichia coli phosphoenolpyruvate carboxylase: effect of allosteric inhibitors on the kinetic parameters and sedimentation behavior.


The clinical-chemical interface of medical science: Its development in this century.


In vitro inhibition of Saccharomyces cerevisiae RNA polymerase by rifamycin derivatives (rifamycins and yeast RNA polymerase).


In memoriam. René Hazard.

In memoriam. René Hazard.


DNA-dependent RNA polymerases isolated from yeast mitochondria.


Deoxyribose-5-P aldolase: subunit structure and composition of active site lysine region.


Gold thioglucose, its toxicity and efficacy in Charles River mice.


A scanning electron microscope study of the human spleen.


Problems of digital amputations: a clinical review of 260 patients and 301 amputations.


Radionecrosis of the neck.

Radionecrosis of the neck.


A combined intracranial and facial approach for excision and repair of cancer of the ethmoid sinuses.


The place of the rosette inhibition test in the preparation and assay of antilymphocytic globulin.


A simple method of measuring host immune rejection response after renal transplantation.


Robert Gordon Craig.

Robert Gordon Craig.


The surgical staging of Hodgkin's disease.


Organ transplantation: the balance sheet to date.


Skin tumours in immunosuppressed patients.


"Transplant leg": skin flap avulsion of the leg due to minor trauma after renal transplantation.


Vesico-ureteric reflux after renal transplantation.


Renal allotransplantation in the rat: method and histological findings.


A comparison of perfusates for 24-hour preservation of ischaemically damaged canine kidneys.


Flap repair of a cervical esophageal stricture.


Bryan Tobyn Keon-Cohen.

Bryan Tobyn Keon-Cohen.


Douglas Miller.

Douglas Miller.


The foundations of neurosurgery in Australia and New Zealand.


The prediction of immediate survival after procine hepatic transplantation.


Secretory function of the primate oviduct.


Cellular aspects of ovum implantation and decidualization in the rat.


Capacitation of mammalian spermatozoa.

Capacitation of mammalian spermatozoa.


Embryogenesis.

Embryogenesis.


Chromosome abnormalities and abortion.

Chromosome abnormalities and abortion.


Fetoplacental hormones and human gestation.


Mechanisms involved in penetration of spermatozoa through the vestments of the mammalian egg.


Comparative aspects of the biochemistry of fertilization: regulatory mechanisms of DNA synthesis.


Species specificity in fertilization.

Species specificity in fertilization.


Clinical trial of pemoline in general practice.


Evidence that glucose 6-phosphate is transported intact in Escherichia coli.


Endocrine genetics.

Endocrine genetics.


Ectopia lentis in systemic heritable disorders.


Problems in the application of cell culture to human genetics.


The ecology of drug therapy.

The ecology of drug therapy.


"New" skeletal dysplasias in the newborn: new X-ray findings.


Fatal neonatal dwarfism: examples of thanatophoric dwarfism and of hypophosphatasia.


Cynicism and medicine.

Cynicism and medicine.


Romanticising the ancient medical profession: the characterization of the physician in the Graeco-Roman novel.


"Doctor William Cullen, physician, Edinburgh": a consultation practice in the Eighteenth Century.


The nose, ambient air, and airway mucosa. A pathway in physiology.


Freud's paper "On Male Hysteria" and the conflict between anatomical and physiological models.


Chasing the cure: Irving Fisher's experience as a tuberculosis patient.


Influenza 1918-1919: a study in mortality.


The Congressional debate over the Seaman's Sickness and Disability Act of 1798: the origins of the continuing debate on the socialization of American medicine.


Imperialism and medical education in China.


From 48 to 46: cytological technique, preconception, and the counting of human chromosomes.


The Fielding H. Garrison Lecture. Blinders of the mind: historical reflections on functional impairment of vision.


Hideyo Noguchi Lecture. George Cheyne, mirror of eighteenth century medicine.


A historical-phenomenological study of bodily pain in Western man.


William Osler Medal Essay. Changing concepts of the nosology of gonorrhea and syphilis.


Carlos Martinez Duran (1906-1974).

Carlos Martinez Duran (1906-1974).


Letter: Epidemiology journals.

Letter: Epidemiology journals.


Samuel Oladele Falayi, 1925-1973.

Samuel Oladele Falayi, 1925-1973.


Current status of aorto-coronary bypass graft surgery.


Clinical significance of monoclonal immunoglobulinemia.


Lymphocyte biology. Part II.

Lymphocyte biology. Part II.


Lymphocyte biology. Part I.

Lymphocyte biology. Part I.


Computer programmes for stereotactic neurosurgery.


Automatically controlled recording and processing of thalamic unit discharges in human sterotaxic operation.


Commemoration of Dr. Henry T. Wycis.

Commemoration of Dr. Henry T. Wycis.


Computer techniques for tracking penetrating electrodes, plotting two-target trajectories and performing two-stage sterotaxic surgery in humans.


Computer calculation to localize subcortical targets in plane x-rays for sterotactic neurosurgery.


Continuous monitoring of muscle tone during surgical exploration of pulvinar, ventro-lateral nucleus of thalamus and globus pallidus.


Treatment of complex forms of extrapyramidal hyperkinesias.


Cystic fibrosis.

Cystic fibrosis.


Evaluation of commercial kits.

Evaluation of commercial kits.


Diffuse intravascular coagulation: an analysis of a basic mechanism of disease.


The PALI and the SLIC systems.

The PALI and the SLIC systems.


Urinalysis, critical discipline of clinical science.


Elevation of plasma gonadotropin concentration in response to mammalian gonadotropin releasing hormone (GRH) treatment of the male brown trout as determined by radioimmunoassay.


Inhibition and stimulation of rat growth hormone secretion in vitro by hypothalamic extracts.


Hormonal response to synthetic LH-releasing hormone (LH-RH) in prepubertal, pubertal, and adult human males.


Effects of nutritional status on gastric secretion and composition in x-irradiated rat.


Growth of human leukaemic peripheral blood cells in diffusion chambers.


Diagnostic accuracy of a 15-lead hybrid computer-aided electrocardiographic system.


Hemodynamic consequences and clinical significance of the handgrip test.


A pilot study for the evaluation of a new regime of combined therapy for the radical treatment of marginally operable rectal (or colo-rectal) cancer.


Pericardial pain in acute myocardial infarction. Double blind trial of steroid therapy.


The formation of bone marrow derived fibroblastic plaques in vitro: preliminary results contrasting these populations to CFU-C.


The future of federal support for family planning services and population research;.


Vasectomania.

Vasectomania. There are 2 legitimate purposes for vasectomy: its prophylatic use before prostatectomy to prevent infection of the epididymus, and as a sterilization operation for men desiring to permanently end their capacity to father children.  No pressure should be exerted on any man to undergo the procedure.  This article traces the historical use of vasectomy for eugenic and other social reasons, besides birth control.  Men should not be told: 1) that it is the best present they can give to their wives, 2) that it is reversible, 3) that men experience greater libido or feelings of better general health, 4) that it was ever used for rejuvenation, 5) that it  is a way to contribute to the solution of the world's problems.  Men should be told that vasectomy is a very effective method of permanent contraception with few medical complications and comparatively little pain.  The free, unprompted, informed decision of a man to terminate his own fertility is the only legitimate reason for vasectomy.


Organized family planning programs in the United States: 1968-1972. The data analyzed in this article show that, notwithstanding differences among agencies, funding sources, and regions, the organized family planning delivery system, as presently constituted, with a varied mix of provider agencies, is serving almost exclusively women of low or marginal incomes.  About 9 in 10 of these women came from families at or below 200% of poverty;  about three-quarters of them were from families at or below 150% of poverty level, and about 7 in 10 were from families at or below 125% of poverty.  However, about 20% of women at or below 150% of poverty received family planning service from private physicians.  As might be expected, as the number of patients served by organized programs grew, more than tripling between 1968 and 1972 to an estimated 2,612,000 women, so did the number of counties in which services were provides and the number of agencies providing the services.  In the course of this rapid growth, the organized family planning programs became one of the major sources not only of medical contraception, but of other preventive health services.  Most of the patients were young (media age was 23), of low parity (media was 1.8, including about 30% childless), with a high school education.  Less than 1/6 (16%) were receiving public assistance.


Direct and indirect financing of family planning programs: project grants and reimbursement mechanisms. This article is an analysis of the likely consequences of one proposed mechanism for implementing new federal policy in the delivery of family planning services by tying the financing into state-administered public welfare systems, specifically through SSA Titles XIX and IV-A.  These were amended by Congress in 1972 to provide federal reimbursements for 90% of all expenditures related to the offering, arranging and furnishing of family services and supplies.  Title IV-A is intended primarily for support of social services;  whereas Title XIX is intended for support of medical services.  However, regulations permit financing of family planning medical services under Title IV-A.  Under these regulations, the states must provide family planning services for all current AFDC recipients (married or unmarried, including sexually active minors) who want these services.  The minimum number eligible for AFDC and at risk of unwanted pregnancy is probably an average of 1.8 million women.  Table 1 presents the maximum annual income levels that families of 1, 2 and 4 could have in each state and still be potentially eligible for Title IV-A family planning services;  Table 2, distribution of states according to annual family income cutoffs;  Table 3, the estimated maximum number of women ages 15-44 at risk of unwanted pregnancy and potentially eligible under Title IV-A regulations.  The number of eligible individuals under Medicaid (Title XIX) is smaller because elibility requirements are stricter.  The future impact of these mechanisms cannot be gauged accurately because it depends on the ability and willingness of the states to utilize these reimbursement mechanisms effectively.


Can State-Administered Programs achieve the national goal?


Using standard data for program evaluation in Cleveland.


Letter: Medicaid gap?

Letter: Medicaid gap?


Immunoelectrophoretic studies in rheumatic fever.


Immunologic control of aging: a possible primary event.


Phenotypic characterization of R-factor tetracycline resistance determinants.


Nature of cellular dificiencies in age-related decline of the immune system.


Lipid metabolism in rheumatic fever.

Lipid metabolism in rheumatic fever.


National health insurance proposals: their effect on family planning and other preventive health services. The Nixon Administration Comprehensive Health Insurance Act of 1974 (H.R.12684, S.2970), Kennedy-Griffiths Health Security Act of 1973, (H.R.22, S.3), the Long-Ribicoff-Waggonner Catastrophic Health Insurance and Medical Reform Act (H.R.  14079, S.2513) and the Mills-Kennedy Comprehensive National Health Insurance Act of 1974 (H.R. 13870, 3286) are compared with respect to general concept, coverage of population, benefit structure, financing, cost sharing, administration,  provider standards and the effect on existing programs.  Family planning services and well-child care are not included in the group of services which are regarded as essential under the Mills-Kennedy or administration proposals.  Both bills exempt these services from a general provision which limits coverage to curative care and services.  The Long-Ribicoff bill mandates the provision of family planning counseling, services and supplies for the low income population as defined in the bill but limits coverage to other persons to catastrophe-related care.  The "model policy" of the bill does not mention family planning or well-child services.


The lactose system in Klebsiella aerogenes V9A. 4. A comparison of the lac operons of Klebsiella and Escherichia coli.


A case of growth retardation and cushing's syndrome due to excessive application of betamethasone-17-valerate ointment.


The effect of lowered body temperature on lifespan and immune and non-immune processes.


Recent articles in ageing research.

Recent articles in ageing research.


The VIP and the psychiatrist.

The VIP and the psychiatrist.


Erythrocyte parameters during induced CA-2+-dependent rapid K+-efflux: optimum conditions for kinetic analysis.


Blood groups and diseases.

Blood groups and diseases.


HL-A in connection with blood transfusion.


The usefulness of scratchard plots in the analysis of antigen-antibody interactions at the surface of the red cell membrane.


Haemo-lymphocytopoiesis. A review.

Haemo-lymphocytopoiesis. A review.


Haemolytic anaemia in malignant lymphoreticuloendothelial diseases.


Short biography of Susan R. Hollán.

Short biography of Susan R. Hollán.


Proceedings: Proteins and RNA present in the peptidyltransferase center as revealed by affinity labeling studies.


Proceedings: Biosynthesis of yeast glycoproteins: in vitro glycosylation of acid phosphatase.


Proceedings: Genetical and biochemical studies of neamine resistant mutants in Escherichia coli.


Proceedings: Inhibition of E. coli DNA polymerase by an acid-soluble factor from synchronized growing yeast.


Proceedings: Stereospecificity of the 20-oxo-reduction of C21-steroids by cultures of Candida albicans.


Proceedings: Specificity of a bacteriophage T2-induced DNA methylase.


Proceedings: Transcriptional units for ribosomal proteins.


Proceedings: On the biosynthesis of the acid phosphatase: studies on a fraction containing precursors of the extracellular enzyme.


Proceedings: Methionine transfer into internal protein positions by isoaccepting met-tRNA species from rabbit reticulocytes and E. coli.


Proceedings: Reversible inhibition of E. coli D-galactoside transport protein (y-gene product) by urea and by aprotic solvents.


Proceedings: Fluorescent labelling with 5-dimethyl-aminonaphthalene-1-sulfonyl chloride of membrane surface proteins of gram-negative bacteria.


Proceedings: Effect of different conformations of gal mRNA on enzyme expression and messenger half-life in RNA-directed cell-free enzyme synthesis.


Proceedings: Carcinogen-induced DNA repair.


Proceedings: Synthetic substrates for chymosin (rennin).


Proceedings: In vitro transcription by DNA-dependent RNA polymerase of E. coli at low pH.


Proceedings: Action of ionophores for divalent cations on human platelets.


Studies on the crystallization of Escherichia coli ribosomes.


A new RNA of high molecular weight in Escherichia coli.


A stimulation-recording technique for evaluating binaural sound processing in porpoises.


Comparison of anti-rheumatic effects of phenylbutazone and ibuprofen.


Pathogenesis of corneal graft failure.

Pathogenesis of corneal graft failure.


Synthesis of some structural analogues of LH-RH modified in position 5, their in vivo and in vitro gonadotropin-releasing activity and immunoreactivity.


Macrolide antibiotics. A literature survey from 1969-1973.


Some new antibiotics reported in 1973.

Some new antibiotics reported in 1973.


Antibiotics Literature Index-a select bibliography.


Ultrasonics in periodontics.

Ultrasonics in periodontics.


Parasexual approaches to mammalian gene regulation.


The pharmacology of isolated cutaneous vascular smooth muscle.


A case of tick bite.

A case of tick bite.


Repressor, operators, and promoters in bacteriophage lambda.


The intestinal cell surface: properties of normal, undifferentiated, and malignant cells.


Gene expression in early animal development: the study of its control by the microinjection of amphibian eggs.


The relevancy of drug control in the United States during the seventies.


Anaphylactic deaths: a clinicopathologic study of 43 cases.


Spina bifida occulta in the parents of offspring with neural tube defects.


Ultrastructural investigations of a modified Bielschowsky silver impregnation technique for boutons.


Local degerming with povidone-iodine, II. Prior to gingivectomy.


Local degerming with povidone-iodine, I. Prior to dental prophylaxis.


Symposium on catecholamines and their enzymes in the neuropathology of schizophrenia. Epilogue.


Behavioral effects of a new dopamine-beta-hydroxylase inhibitor (fusaric acid) in man.


Enzymatic-isotopic micromethods for the measurement of biogenic amines in brain tissue and body fluids.


Immunological localization of dopamine-beta-hydroxylase on the chromaffin granule membrane.


A pilot study of pimozide in schizophrenia.


Early descriptions of antibiosis.

Early descriptions of antibiosis.


The changing self-concept of black children. The black identity test.


Pyelonephritis in pregnancy.

Pyelonephritis in pregnancy.


John Wesley Lawlah, B.S., M.S., M.D., D.Sc., 1904-radiologist, medical administrator, teacher.


Nitrate reductase in E. coli: properties of the enzyme and in vitro reconstitution from enzyme-deficient mutants.


The development of the virus concept as reflected in corpora of studies on individual pathogens. 1. Beginnings at the turn of the century.


Michele Savonarola and the fera or blighted twin phenomenon.


The Sydenham-Boyle theory of morbific particles.


Swift and the physicians: aspects of satire and status.


London's immigrant apothecaries, 1600-1800.


John Nott, M.D. 1751-1825. The Oriental travels of an eighteenth-century physician.


Some early Nigerian doctors and their contribution to modern medicine in West Africa.


Description of an antique radium-goblet; a dangerous curiosity.


Rationales for therapy in British psychiatry: 1780-1835.


Samuel Barrow, M.D. physician to Charles II and admirer of John Milton.


Some difficult confinements in Seventeenth-Century Yorkshire.


Accumulation of lipofuscin in the myocardium of senile guinea pigs: dissolution and removal of lipofuscin following dimethylaminoethyl p-chlorophenoxyacetate administration. An electron microscopic study.


A medico-legal report of the Sixteenth Century from Malta.


The first blood transfusion: French of English?


Osteochondritis dissecans in ancient British skeletal material.


The Puritan connexions of Sir Edward Alston, President of the Royal College of Physicians 1655-1666.


Medical evidence in the assassination of President John F. Kennedy.


Computer generated track and field scoring tables: I. Historical development.


A simple technique for the estimation of viral antibody levels by immunofluorescence.


A study of the coagulase and deoxyribonuclease tests applied to staphylococci from non-human sources.


The growth of Salmonella dublin and Salmonella typhimurium on MacConkey media containing brilliant green.


Estimation of rubella-specific IgM antibody in sera by single fraction collection on sephadex G-200.


Dr. Benjamin W. McCready.

Dr. Benjamin W. McCready.


Vestibular pharmacology of flunarizine compared to that of cinnarizine.


Review of candidal vaginitis - use of candicidin in its treatment.


Preservation of human kidneys for transplantation.


Research on adaptation to rearranged vision: 1966-1974.


The effect of egg shell quality on penetration by various salmonellae.


Simmond's disease. Morris Simmonds, (1855-1925).


Remembered by epigram. Sir William Browne, M.D., F.R.S. (1692-1774).


Electron resonance studies of photosynthetic systems.


The in vitro antacid and anti-pepsin activity of hydrotalcite.


Mode of photosensitizing action of furocoumarins.


Photosensitivity in porphyria.

Photosensitivity in porphyria.


Ultraviolet action and photoreactivation in algae.


Separation of an activator of purified DNA photolyase from Baker's yeast.


Chromosome abberations induced by ultraviolet radiation.


A kinetic and thermodynamic analysis of tRNA binding in the ribosomal complex.


Photochemistry of nucleic acids and their constituents.


Carbamoylation of tRNA from yeast and rat liver.


An advance in the use of ultrasound: developments at the Royal Marsden.


Antibodies to candida and autoantibodies in sub-acute bacterial endocarditis.


Stephanie-Felicite du Crest la Comtesse de Genlis (1746-1831) early female proponent of physical education.


Demonstration of the antinuclear factors by immunofluorescence using as a source of antigens rat liver imprints.


Therpaeutic value of a new antirheumatic drug.


C. I. Parhon's birth centenary.

C. I. Parhon's birth centenary.


Ultrastructural study of the endocrine pancreas in the genetically obese mouse compared with the normal one.


Respirophonographical measurements of the effect of bromhexin in the treatment of chronic bronchitis.


The short-term clinical evaluation of bromhexine in chronic bronchitis.


Bronchodilator effect of oral salbutamol and an ephedrine+theophylline+hydroxyzine combination in asthmatic out-patients.


Mucolytic treatment of chronic bronchitis during two winter periods.


Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (guaiacol glyceryl ether).


Review of studies on environmental tobacco smoke.


Experimental studies on bronchial secretion. Therapeutical aspects of pathological bronchial secretion.


Characteristics of tobacco sidestream smoke and factors influencing its concentration and distribution in occupied spaces.


The effects of low concentration of carbon monoxide in man.


Effects of tobacco smoke on biological systems.


Haemodynamic studies in occlusive disease of the subclavian artery and the brachiocephalic trunk in man.


Hazards of cornary arteriography.

Hazards of cornary arteriography.


The roentgen pathology of coronary artery disease.


Alexander A.Krieger, MD.

Alexander A.Krieger, MD.


American ophthalmological society. Members.


Refractive errors following keratoplasty.


L. Conner Moss, MD.

L. Conner Moss, MD.


Expulsive hemorrhage: some observations and comments.


Arthur J. BEDELL, MD.

Arthur J. BEDELL, MD.


Walter F. Duggan, MD.

Walter F. Duggan, MD.


Computerized transaxial tomography in neuro-ophthalmology.


Embedding of the isolated enamel organ of the rat incisor for electron microscopy.


Epidemiology of symptomatic urinary tract infection in childhood.


Turku sugar studies. III. An intermediate report on the effect of sucrose, fructose and xylitol diets on the numbers of salivary lactobacilli, candida and streptococci.


Hepatic circulation in hepatitis A.

Hepatic circulation in hepatitis A.


The peripheral nerve function in chronic renal failure. A survey.


Characterization of recombinants obtained by crossing Escherichia coli with Shigella sonnei.


Description of mutants of Escherichia coli Hfr H deficient in surface exclusion.


An attempt at the identification of phage receptors in Shigella flexneri.


Indications for control mechanisms in purine and pyrimidine biosynthesis as revealed by studies with inhibitors.


Endotoxin-mediated decrease in content of RNA, DNA, and protein of spleen and lymph nodes in neonatally thymectomized rats immunized with sheep erythrocytes.


Historical review of the analytical control of insulin.


Stimulation of in vitro release of free fatty acids from adipose tissue by adenohypophyseal homogenates from endotoxin-treated rabbits.


The regulation of nuclear DNA template restrictions by acidic polymers.


Immunological investigations of the structure and antigens of Shigella sonnei and serologically related bacteria.


Function of bile acids in the intestinal absorption of endotoxin in rats.


Diminished turnover of plasma iron in pigs after injection of endotoxin.


Antibody production in rats treated with endotoxin.


Increased serum ribonuclease activity during endotoxin shock in rats.


Biochemistry and biological activity of the complement system.


Separation of free and antibody-bound glucagon by means of charcoal and ethanol precipitation.


Production of anti-glucagon rabbit serum for radioimmunoassay.


An immunofluorescent method for the diagnosis of the immunopathies of the thyroid gland.


Automated method for determination of penicillins, cephalosporins, and penicillinases. The microiodometric assay of Novick for penicillinase was adapted to the Technicon Autoanalyzer system. With this automated method, it is possible to analyze almost 60 samples per hr. Two different procedures are described: in the first, the samples were incubated with substrate in the machine under standardized conditions; in the second, samples were incubated outside the Autoanalyzer and assayed at intervals for penicilloic acid. As little as 5 mum penicilloic acid could easily be detected in a sample of 0.4 ml. The reproducibility was very good. The hydrolysis of penicillin in a suspension of nongrowing bacteria as well as in a growing culture could also be followed. The automated method has been used both for kinetic studies and in screening for activity in eluates from column chromatography experiments.


Antibacterial activity of lividomycin toward R factor-resistant strains of Escherichia coli. Forty-eight R factors conferring resistance to both kanamycin (KM) and streptomycin (SM) were demonstrated from 1,270 Escherichia coli strains of clinical origin. Among these R factors isolated, 42 also conferred resistance to the new antibiotic lividomycin (LV). Extracts of E. coli ML1410 carrying one such factor (R(M81)) inactivated LV as well as KM and SM. But extracts of E. coli ML1410 carrying an R factor (R(M82) or R(M83)) sensitive to LV could not inactivate LV. LV inactivation required both adenosinetriphosphate (ATP) and Mg(2+). Inactivated LV was reactivable by alkaline phosphatase. Isotopic studies with labeled ATP and elemental analysis of the reaction product indicate that it is a monophosphorylated derivative of LV.


Effect of antibacterial therapy on renal lysozyme levels in rats developing bacterial pyelonephritis. In animals developing unilateral Proteus mirabilis-induced pyelonephritis, the total soluble renal lysozyme (SRL) of both kidneys undergoes a biphasic elevation. The second phase of elevated SRL is associated with the onset of chronicity in the infected kidney. To discover whether effective antibacterial therapy altered the second elevation of SRL, levels of SRL were determined in rats developing unilateral chronic pyelonephritis with and without effective regimens of antibacterial agents. Therapeutic doses of ampicillin and nitrofurantoin caused elevations of SRL in both kidneys of infected animals, but these differences were not statistically significant (P > 0.05). Both agents produce elevations of SRL in uninfected animals which were significant (P < 0.05) when compared with normal animals. Kanamycin sulfate at a therapeutic dose induced great elevations of SRL in kidneys of both infected and uninfected animals. It is concluded that infection per se is not the cause of the elevated SRL.


Microiodometric determination of beta-lactamase activity. The product of beta-lactamase activity (a penicilloic acid in the case of a penicillin) is stoichiometrically oxidized by iodine. Hence, the beta-lactamase activity can be measured as decolorization of the blue starch-iodine complex. Since the decolorization is a slow process, the rate of decolorization gave an underestimate of the rate of penicillin hydrolysis until a steady state was obtained after 15 to 20 min. If the reaction mixture (3 ml) contained no more than 0.001 unit of enzyme, a correct determination of beta-lactamase activity was obtained from the microiodometric method described. The method is sensitive and some applications are mentioned.


The elusive permeability barriers and binding sites for proflavine in Escherichia coli. Cells of proflavine-sensitive and -resistant Escherichia coli strains were altered in different ways, and the proflavine binding of the changed material was studied. Spheroplasts prepared from sensitive and resistant cells bound similar amounts of proflavine at saturation, whether or not they were osmotically protected by 10% sucrose. Intact cells bound approximately the same amounts of proflavine as spheroplasts. On addition of glucose, osmotically protected resistant but not sensitive spheroplasts released proflavine; unprotected spheroplasts did not release bound proflavine. Thus, osmotically protected membranes are not required for proflavine binding (a passive process) but are required for proflavine release (an active process). The presence of sucrose reduced proflavine binding by resistant cells. Adding glucose to cells in 20% sucrose did not cause a release of residual proflavine, though glucose caused a release of proflavine from cells suspended in 0 or 10% sucrose. On treatment of heated cells or ruptured spheroplasts with nucleases and Pronase, practically all nucleic acids were removed. Proflavine-binding ability of such preparations fell by only 30 to 50%. Washing heated cells with ethanol did not reduce their proflavine-binding ability. There appear to be important binding sites in cells aside from nucleic acids.


Effect of elevated atmospheric pressure on antibiotic susceptibility of Staphylococcus aureus and Streptococcus pyogenes. Staphylococcus aureus showed decreased susceptibility to penicillin, vancomycin, sodium cephalothin, and tetracycline, but increased susceptibility to sodium colistimethate, at a pressure of 68 atm in helium or helium-oxygen gas. Susceptibility of Streptococcus pyogenes was unchanged by pressurization.


In vitro susceptibility of Shigella strains to trimethoprim and sulfamethoxazole. Trimethoprim and sulfamethoxazole were tested alone and in combination against 227 recently isolated Shigella strains. Variations in medium constituents and inoculum size were used to determine the optimal testing conditions. The plate dilution method with addition of 5% lysed horse blood to the susceptibility test medium and an inoculum size of 10(2) organisms was found to provide satisfactory results. All 227 strains were inhibited by low concentrations of trimethoprim, and all were susceptible to the combination of 0.06 mug of trimethoprim per ml and 1.25 mug of sulfamethoxazole per ml. Sixteen percent of these strains were resistant to ampicillin, 33% to tetracycline, 15% to chloramphenicol, and 27% to cephalothin. Based on these in vitro observations, trimethoprim and sulfamethoxazole appear worth evaluating for treatment of shigellosis due to multiply antibiotic-resistant strains.


Effect of R-factor-mediated drug-metabolizing enzymes on survival of Escherichia coli K-12 in presence of ampicillin, chloramphenicol, or streptomycin. Escherichia coli K-12 carrying the R-factor R1 is resistant to ampicillin, chloramphenicol, and streptomycin. This resistance is due to R-factor-coded enzymes that metabolize the drugs. The effects of these enzymes on the survival of cell populations were studied in the presence of high concentrations of antibiotics. For all three antibiotics there were considerable inoculum effects. For ampicillin and chloramphenicol, the inoculum effect was due to detoxification of the medium, whereas streptomycin was not significantly metabolized. The survival of the population in the presence of streptomycin was due to the presence of resistant mutants. At high concentrations of ampicillin or chloramphenicol, the surviving cells were not mutants. Survival in the presence of ampicillin is presumably due to variations in resistance during the cell division cycle. The rate of acetylation of chloramphenicol decreased with time and was zero after 1 to 2 h. Treatment with high concentrations of chloramphenicol did not cause lysis of the cells but partially opened the outer membrane, causing excretion of beta-lactamase.


Mutations in Escherichia coli K-12 decreasing the rate of streptomycin uptake: synergism with R-factor-mediated capacity to inactivate streptomycin. Escherichia coli K-12 carrying the R-factor R1 or R6K is resistant to streptomycin. The resistance is due to R-factor-coded enzymes that metabolize the drug. Streptomycin can be inactivated in two ways, either by adenylylation or by phosphorylation; both reactions require adenosine 5'-triphosphate. In this work we show that the R-factor R1 codes for an enzyme that adenylylates streptomycin and that the enzyme activity is located in the periplasmic volume, whereas the R-factor R6K codes for a streptomycin phosphorylase, which is mainly cytoplasmic. From a strain without any R-factor or carrying different R-factors, mutants were isolated that are 10 times more resistant to streptomycin than the parent strains. This increased resistance is not due to increased amounts of metabolizing enzymes. The mutants have a decreased rate of uptake of streptomycin and an altered response to other antibacterial agents as well. The mutations are located on the chromosome and not on the plasmid. It is likely that the mutations cause changes in the outer layers of the cell envelope and that the increased resistance is due to the synergistic effect of an efficient penetration barrier and a low activity of inactivating enzyme.


Isolation, characterization, and action of colicin M. Colicin M was isolated from Escherichia coli K-12 32T 19F/T1. The purified, biologically active protein had a molecular weight of 27,000. It contained phosphatidyl ethanolamine. The molecular weight found for the polypeptide chain by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate was 18,000. Colicin M was found to be firmly integrated in the membrane of the producing strain. The action of the colicin seems to be on the membrane, since cells of the susceptible strain E. coli K-12 ROW/V/22.1 lyse rapidly. Using the phase contrast microscope, lysis was followed by decrease in turbidity of the cell culture and release of protein into the medium. Lysis started at about 15 min after addition of colicin M and was completed after 40 to 60 min. At this time, one-third of the protein had been released from the cells. The number of viable cells dropped within 10 min to 0.01%. Colicin M induced formation of spheroplasts in the presence of 16% sucrose. The electron microscope examination revealed that at first bulges in the cell envelope appear, most frequently occurring equatorially but also occurring at sites all over the cell. In the process of spheroplast formation, the cytoplasmic membrane often retreats from one-half of the outer membrane so that the cytoplasm is confined to one hemisphere. Sucrose did not prevent cells from dying unless cells were pregrown in a sucrose containing medium for several generations before colicin M was added. With cells pregrown in the presence of sucrose, the number of survivors was 100 times higher than in the absence of sucrose.


Characterization of a plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain Streptococcus pyogenes. A plasmid determining resistance to erythromycin, lincomycin, and vernamycin B(alpha) was isolated from a strain of Streptococcus pyogenes. The plasmid has a molecular weight of approximately 17 x 10(6) and is present to the extent of one to two copies per chromosomal genome equivalent.


Detection of an R factor showing temperature-sensitive transfer in Salmonella typhimurium isolated from calves. An R factor carrying tetracycline resistance, the transfer of which was observed in mating cultures at 25 but not at 37 C, was demonstrated in strains of Salmonella typhimurium isolated from calves.


Historical and contemporary trends in illegitimacy.


Effect of contraceptive pills on sexual activity in the luteal phase of the human menstrual cycle.


The history of pulse taking.

The history of pulse taking.


Recall of tumour resistance in long-term Salmonella enteritidis 11RX immunised mice.


Anaerobic bacteriology. Isolation and identification of Bacteroides and Fusobacterium from human sources.


Selective renal angiography in renal failure due to infection.


Chemically modified nylons as supports for enzyme immobilization. Polyisonitrile-nylon. Four-component condensations between amine, carboxyl, isocyanide and aldehyde lead to the formation of N-substituted amides (Ugi, 1962). The present paper describes the use of such condensations for the introduction of chemically reactive groups on to the polyamide backbone of nylon. Polyisonitrile-nylon was synthesized by partial hydrolysis of nylon-6 powder, followed by resealing of the newly formed -CO(2)... NH(2) (-) pairs via a four-component condensation, by using acetaldehyde and 1,6-di-isocyanohexane. Polyisonitrile-nylon could also be converted into a diazotizable arylamino derivative, polyaminoaryl-nylon, by a four-component condensation by using a bifunctional amine, pp'-diaminodiphenylmethane, in the presence of an aldehyde and a carboxylate compound. The versatility of four-component condensations involving the isocyanide functional group of polyisonitrile-nylon allowed coupling of proteins, in an aqueous medium at neutral pH, through either their amino or carboxyl groups. Trypsin and papain were bound to polyisonitrile-nylon through their amino groups by a four-component condensation by using acetaldehyde and acetate; conversely, succinyl-(3-carboxypropionyl-)trypsin, pepsin and papain were coupled through their carboxyl groups in the presence of acetaldehyde and an amine (Tris). Diazotized polyaminoaryl-nylon could be utilized for the immobilization of papain, via the tyrosine residues of the enzyme.


Topography of Escherichia coli ribosomal proteins. The order of reactivity of thiol groups. 1. 30S and 50S ribosomal subunits of Escherichia coli were treated with N-[2,3-(14)C]-ethylmaleimide and iodo[(14)C]acetamide. 2. The proteins in the native subunits which reacted with the reagents were S1,double dagger S2, S12, S13, S18, S21, L2, L5, L6, L10, L11, L15, L17, L20, L26+28 and L27. 3. Several proteins, such as S1, S12, S14, S18, L2, L6, L10, L11 and either L26 or 28, had thiol groups in an oxidized form and reacted to a greater extent after reduction with beta-mercaptoethanol or dithiothreitol. 4. The total number of thiol groups in 30S and 50S subunits was determined as 16-17 and 26-27 respectively. The total number of thiol groups in each ribosomal protein was also determined. 5. The reaction of 30S and 50S subunits with iodoacetamide under several different conditions established the order of reactivity of thiol groups.


The copolymeric structure of pig skin dermatan suplhate. Characterization of D-glucuronic acid-containing oligosaccharides isolated after controlled degradation of oxydermatan sulphate. Selective periodate oxidation of unsubstituted l-iduronic acid residues in copolymeric dermatan sulphate chains was followed by reduction-hydrolysis or alkaline elimination. By this procedure the glucuronic acid-containing periods were isolated in oligosaccharide form; general formula: [Formula: see text] Further degradation of these oligosaccharides with chondroitinase-AC yielded three types of products: (a) sulphated trisaccharide containing an unsaturated uronosyl moiety in the non-reducing terminal and a C(4) fragment in the reducing terminal, DeltaUA-GalNAc-(-SO(4))-R; (b) monosulphated, unsaturated disaccharide, DeltaUA-GalNAc-SO(4) when n is greater than or equal to 2; and (c) N-acetylgalactosamine with or without sulphate. Oligosaccharides containing a single glucuronic acid residue (n=1) comprised more than half of the glucuronic acid-containing oligosaccharides. The terminal N-acetylgalactosamine moiety of the shortest oligosaccharide was largely 4-sulphated, whereas higher oligosaccharides primarily contained 6-sulphated or unsulphated hexosamine moieties in the same position. Moreover, IdUA-SO(4)-containing oligosaccharides were encountered. These oligosaccharides were resistant to the action of chondroitinase-ABC.


The hybridization of glyceraldehyde 3-phosphate dehydrogenases from rabbit muscle and yeast. Kinetics and thermodynamics of the reaction and isolation of the hybrid. A kinetic and thermodynamic study was made of the formation of the hybrid (R(2)Y(2)) glyceraldehyde 3-phosphate dehydrogenase from the yeast (Y(4)) and rabbit (R(4)) enzymes. The values of the thermodynamic parameters for the equilibrium between R(4), Y(4) and R(2)Y(2) suggest that the R(2)-R(2) and Y(2)-Y(2) interactions are similar. However, the failure to observe the RY(3) and R(3)Y hybrids is interpreted in terms of differences at the interfaces of the R-R and Y-Y interactions (the glyceraldehyde 3-phosphate dehydrogenase molecule being regarded as a dimer of dimers). The kinetics of formation of the R(2)Y(2) hybrid were studied and a model was proposed to account for the results. Best-fit values for the rate constants of the individual steps were evaluated by computer simulation, and the rate-limiting steps were identified as the dissociation of tetramers to dimers. It is proposed that the cleavage plane for dissociation of the tetramers corresponds to the region of low electron density through the centre of the molecule in the X-ray-crystallographic structure for human glyceraldehyde 3-phosphate dehydrogenase (Watson et al., 1972), which is probably the plane containing the Q and R axes in the lobster enzyme (Buehner et al., 1974). The R(2)Y(2) hybrid was isolated in milligram amounts by ion-exchange chromatography and its rate of reversion to the native enzyme was shown to be consistent with the kinetic model proposed from the hybrid-formation experiments.


Yeast protein synthesis. Preparation and analysis of a highly active cell-free system. A detailed description is given of the techniques for preparing, handling and assaying a cell-free protein-synthesizing system from yeast, analogous to crude (S-30) Escherichia coli extracts. Its basic characteristics are described. The rate of poly(U)-directed polyphenylalanine synthesis was at least fivefold higher than in previously reported yeast cell-free systems, approaching that of crude mammalian cell-free systems. Fractionation of the S-30 extracts lowered activity. Organelles and their fragments present in the S-30 extract neither contributed to nor inhibited cytoplasmic protein synthesis. There was a component localized in the high-speed supernatant that caused an inhibition of polyphenylalanine synthesis. Poly(U) programmed the synthesis of long-chain polyphenylalanine, in contrast with the only other yeast system in which this has been examined (Bretthauer & Golichowski, 1968). Preincubation techniques inactivated the system and probably a small proportion only of the ribosomes was active.


Proton/sodium ion antiport in Escherichia coli. In anaerobic suspensions of Escherichia coli, after H(+) ions have been translocated outwards across the plasma membrane by a respiratory pulse, re-equilibration is catalysed by Na(+). The sudden addition of a Na(+) salt causes the effective outward translocation of H(+) by an electroneutral process. We conclude that the plasma membrane of E. coli contains a Na(+)/H(+) antiport system that normally translocates Na(+) outwards under the influence of an inwardly directed H(+)-activity gradient.


The effect of temperature and light combinations upon the gonads of male red-back voles.


Simulation of biogenic amine metabolism in the brain. The metabolism of a number of biogenic amines has been simulated by using data obtained from studies of the individual enzymes from pig brain. It is shown that beta-hydroxylated amines such as noradrenaline and octopamine are metabolized primarily to the alcoholic metabolite whereas amines lacking this group [e.g. dopamine (3,4-dihydroxyphenethylamine) and 5-hydroxytryptamine] are metabolized at low concentrations to give the corresponding acid. Increase in the amine concentration results in an increase in the proportion of the alcoholic metabolite formed and this may in part account for the effects of the drug reserpine on amine metabolism. The effects of disulfiram (Antabuse) and ethanol (acting through its metabolite acetaldehyde) on amine metabolism may be understood in terms of this simulated model. It is shown that drugs that affect this system also cause alterations in the steady-state concentrations of the intermediate aldehydes and the possible implications of this are discussed.


Biogenesis of mitchondria. Phospholipid synthesis in vitro by yeast mitochondrial and microsomal fractions. The ability in vitro of yeast mitochondrial and microsomal fractions to synthesize lipid de novo was measured. The major phospholipids synthesized from sn-[2-(3)H]glycerol 3-phosphate by the two microsomal fractions were phosphatidylserine, phosphatidylinositol and phosphatidic acid. The mitochondrial fraction, which had a higher specific activity for total glycerolipid synthesis, synthesized phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidic acid, together with smaller amounts of neutral lipids and diphosphatidylglycerol. Phosphatidylcholine synthesis from both S-adenosyl[Me-(14)C]methionine and CDP-[Me-(14)C]choline appeared to be localized in the microsomal fraction.


Capacitation in the mouse: the response of murine acrosomes to the environment of the female reproductive tract.


The effect of immunostimulation and chemotherapy on the growth of reticulosarcoma in mice.


National priorities in the artificial kidney program.


Sensory aids.

Sensory aids.


Current state of the VA research effort at the Western Blind Rehabilitation Center.


Veterans Administration conference on prosthetics and sensory aids. July 20-23, 1974. Current state of the art. Needs of the Veterans Administration.


VA Prosthetics Center program for electric wheelchairs and other nonlicensed mobility aids.


Research at the Eastern Blind Rehabilitation Center.


Current state of the research effort at Veterans Administration Hospital, Hines, Illinois.


Veterans Administration conference of prosthetics and sensory aids. July 20-23, 1974. Shaping the future: workshop panel discussions.


VA Prosthetics Center research, development, and evaluation program.


Veterans Administration conference of prosthetics and sensory aids. July 20-23, 1974. Welcoming address.


Veterans Administration conference of prosthetics and sensory aids. July 20-23, 1974. General discussion and closing remarks.


Hearing aids and the Veterans Administration.


Reading aids for the blind.

Reading aids for the blind.


Mobility aids for the blind.

Mobility aids for the blind.


Butorphanol: a double-blind evaluation in postoperative patients with moderate or severe pain.


A ventilator adapter for fibreoptic bronchoscopy.


Cholera nomenclature and nosology: a historical note. The term "cholera" appears several times in the Hippocratic writings, and for more than 2 000 years designated ill-defined sporadic gastrointestinal derangements of diverse etiology. When the first pandemic of Asiatic cholera started in 1817, the superficial resemblance of its symptoms to those of "cholera" led to its being given the same name, although there were many objections to this nomenclature and numerous other diagnostic terms were proposed. Some thought that Asiatic cholera was an entirely new disease, while others believed that the old "cholera" had newly become "epidemic". This terminological confusion befogged ideas on the nature and epidemiology of Asiatic cholera for many years, and especially after 1830, when the disease began to spread widely over Europe.


Bancroftian filariasis in the Sudan.

Bancroftian filariasis in the Sudan. The authors present and discuss the results of a survey carried out in the Farbronga and Habeila areas and in the Nuba mountains of the Sudan to ascertain the incidence of filariasis due to Wuchereria bancrofti.


Diazepam-pentazocine anaesthesia for cardiovascular surgery.


The evaluation of hyponatremia, with some observations on the syndrome of inappropriate secretion of antidiuretic hormone.


The growth of human tumours in immune deprived mice.


A clinical study of the natural history of lymphosarcoma and reticulum cell sarcoma.


Effect of testosterone and estradiol on the basal and LRF-stimulated secretion of gonadotropins in pituitary cell culture.


The effect of cell dose and distribution on the development of a transplanted tumour.


A historical perspective on physiological monitoring: Sherrington's mammalian laboratory and its antecedents.


Longitudinal growth of the seminiferous tubules in rats and its hormonal control.


Components of sperm maturation in the human epididymis.


Metabolism of spermatozoa with particular relation to the epididymis.


Mechanisms of sperm transport in the male and female tract.


Review on metabolic and enzymic studies of spermatozoa from the ampullae ductus deferentiae of bulls.


Sperm ultrastructure as an indication of sterility.


Condoms and things.

Condoms and things.


Immunofluorescent assay of anti-human thymocyte globulin as a means of correlating "in vitro" and "in vivo" activity.


Studies on the assessment and titration of antilymphocytic sera "in vitro" and "in vivo".


"In vivo" standardization model for defining the dose-response-dependent graft-protective value of antilymphocyte sera.


Comparison of antibody content in human IgG and human IgG enriched with IgA.


Relation between gut motility and innervation in man.


What is gastrin? A progress report on the heterogeneity of gastrin in serum and tissue.


Sulfation of bile salts: a new metabolic pathway.


Portal-systemic shunts in patients with cirrhosis. The need of controlled clinical trials.


An alternate mechanism for the formation of protein plugs in chronic calcifying pancreatitis.


Stagnant loop syndrome resulting from small-bowel irradiation injury and intestinal by-pass. Stagnant or blind-loop syndrome includes vitamin B12 malabsorption, steatorrhea, and bacterial overgrowth of the small intestine. A case is presented to demonstrate this syndrome occurring after small-bowel irradiation injury with exaggeration postenterocolic by-pass. Alteration of normal small-bowel flora is basic to development of the stagnant-loop syndrome. Certain strains of bacteria as Bacteriodes and E. coli are capable of producing a malabsorption state. Definitive therapy for this syndrome developing after severe irradiation injury and intestinal by-pass includes antibiotics. Rapid symptomatic relief from diarrhea and improved malabsorption studies usually follow appropriate antibiotic therapy. Recolonization of the loop(s) with the offending bacterial species may produce exacerbation of symptoms. Since antibiotics are effective, recognition of this syndrome is important. Foul diarrheal stools should not be considered a  necessary consequence of irradiation injury and intestinal by-pass.


Hormones and the aetiology of human breast cancer.


Failure of pepsin-digested donor specific alloantibody to prolong renal allograft survival in dogs.


Phagocytosis-inhibiting properties of human serum alpha-1 acid glycoprotein.


The isolation of migration inhibition factor.


Capitalizing on illness: the health insurance industry.


Properties of reticulum-cell sarcomas in SJL/J mice. I. Proliferative response to tumor cells of T-derived lymphoid cells from normal mice. Cells from reticulum-cell sarcomas (RCS), tumors with a probable B-cell origin in the SJL/J mouse strain, induced a high degree of proliferation in O-bearing syngeneic lymph-node and thymus cells obtained from young non-tumours mice. Although of considerably lower magnitude, a proliferation of SJL/J thymus cells to syngeneic normal lymph-node cells was also noted. Sera from normal syngeneic mice did not block either of these proliferative responses. Stimulation by RCS cells also occurred with normal lymph-node cells from F1 hybrids, SJL/J times C57Bl/6, and SJL/J times ASW and from the H-2s identical ASW mouse strain. It is suggested that these results are due either to the presence of viral antigens on the surface of RCS cells or to an exaggerated form of the normal syngeneic response of T to B lymphocytes. Another tumor of B-cell origin, the PU5 tumor of BALB/c mice, failed to induce proliferation in normal syngeneic lymph-node or thymus cells.


Gender and objectivity in medicine.

Gender and objectivity in medicine.


Isoenzymes of lactic dehydrogenase in human gingival fluid.


Two improvements in two-part denture design.


Intracrevicular sampling of leukocytes using plastic strips.


Concepts of soft-palate prosthesis.

Concepts of soft-palate prosthesis.


The design of the partial denture framework. I. Introduction and the design of the partial denture base.


Two modifications of the lower disjunct partial denture.


Isolation of Cryptococcus neoformans from soil contaminated with pigeon droppings in Bangkok.


Early experience in renal transplantation in Thailand.


Studies of the feasibility of the indirect fluorescent antibody technique to detect contamination of shrimp by V. parahemolyticus.


Prospect of computers in medical diagnoses.


Evaluation of a conventional screening scheme for Enterobacteriaceae.


Irradiated cells and blastema formation in the adult newt, Notophthalmus viridescens.


Ontogeny and localization of the lens crystallins in Xenopus laevis lens regeneration.


The site of action of the fuzzy locus (fz) in the mouse, as determined by dermal-epidermal recombinations.


Comparison of pyrantel pamoate syrup and pyrvinium pamoate syrup in the treatment of enterobiasis in Egypt.


Bibliography of foreign literature on antibiotics. CVI.


A new method for measurement of right ventricular residual ratio using 121I-MAA. A new technique of precordial counting with 131I-MAA for measurement of right ventricular residual ratio (RVRR) was described. 131I-MAA was rapidly injected injected into the right ventricle at the time of right heart catheterization. The fraction of isotope discharged from this chamber per beat was determined with a crystal detector with tapered collimator which was pointed to the center of right ventricle. The radioisotope dilution curve was corrected by using the lung built up curve recorded by the other detector pointed to the lung field. Then, the right ventricular end-systolic volume (ESV) and the right ventricular end-diastolic volume (EDV) were calculated from the RVRR and stroke volume. In 6 patients with normal hemodynamics, the RVRR averaged 57.8 plus or minus 4.9%, the ESV 52.2 plus or minus 13.6 ml/M(2) and the EDV 89.4 plus or minus 15.1 ml/M(2). In 16 patients with heart diseases, the RVRR averaged 60.6 plus or minus 7.1%, the ESV 80.6 plus or minus 34.0 ml/M(2) and the EDV 127.2 plus or minus 43.6 ml/M(2). In 11 patients with chronic pulmonary diseases, the RVRR averaged 70.7 plus or minus 9.9%, the ESV 94.7 plus or minus 42.4 ml/M(2) and the EDV 133.0 plus or minus 46.5 ml/M(2). The RVRR in the last group increased significantly.


Cardiovascular studies of 5-(3-tert-butylamino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent beta-adrenergic blocking agent. The beta-adrenergic blocking and hemodynamic properties of 5-(3-tert-butyl-amino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085) were investigated and compared with those of propranolol and pindolol on myocardial contractile force, heart rate and arterial blood pressure in pentobarbital anesthetized dogs. OPC-1085 showed almost the same beta-adrenergic blocking potency as pindolol, but was approximately 30 and 20 times stronger than propranolol against isoproterenol and cardiac nerve stimulation, respectively. Slight negative inotropic and chronotropic responses were observed with OPC-1085 in effective blocking doses from 1 to 10 mug/kg but were converted to positive ones in doses from 30 to 3000 mug/kg in non-reserpinized dogs. In reserpinized dogs, both OPC-1085 and pindolol induced only positive responses. These responses were more evident with OPC-1085.


The history of the discovery of the vegatative (autonomic) nervous system.


Thomas Peel Dunhill, the forgotten man of thyroid surgery.


Medicine, the City and China.

Medicine, the City and China.


Sir William Paddy , M.D. (1554-1634).

Sir William Paddy , M.D. (1554-1634).


Niccoló Moranghelli, a libellous physician.


Surgical instruments on a tomb slab in Roman Malta.


A little-known portrait of Giovanni Alfonso Borelli.


Some observations on the history of the use of barium salts in medicine.


Pioneers in anaesthesia.

Pioneers in anaesthesia.


On mental illness: a review.

On mental illness: a review.


Cytogenetics of triatominae: II-Spermatogenesis in hybrid between Triatoma infestans and Triatoma pseudomaculata (Hemiptera, reduviidae)


Suppression of photically evoked after-discharge bursting following administration of anticonvulsants in waking rats.


Schools council curriculum materials.

Schools council curriculum materials.


Spina bifida: some psychological aspects.


Charles B. Huggins, MD, FACS (hon).

Charles B. Huggins, MD, FACS (hon).


Adjuvant preoperative and postoperative immunochemotherapy for mammary adenocarcinoma in rats.


Cardiopulmonary alterations during clinical use of the membrane lung oxygenator.


Cardiac transplantation following failure of previous cardiac surgery.


The transplanted human heart in the early postoperative period.


Atrial pacing wires in orthotopic cardiac allotransplantation.


Effect of Concanavalin A on rat heart allografts.


Tolerance induction and transplantation of the mouse heart.


Cerebral etiology of the pulmonary lesions of "oxygen toxicity".


Long-term fate of lung autografts charged with providing total pulmonary function.


In vivo alveolar morphometrics with positive end expiratory pressure.


Effect of continuous positive airway pressure on extravascular lung water.


Airway pressure and pulmonary edema formation.


Treatment of acute respiratory insufficiency with cyclic expiratory pressure.


Prevention of gastric ulcer following pig liver transplantation by vagotomy-pyloroplasty.


Respiratory epithelium changes in long-term survivors with bilateral lung allografts.


Canine renal allograft rejection and antibody formation following blood transfusions.


Timing of splenectomy in human kidney transplantation.


Cellular immune response in HL-A identical renal transplant recipients.


Pancreatic duct ligation and long-term endocrine function of pancreas transplants.


Enhancement of infection by corticosteroids: experimental clarification.


Total recovery of ischemic kidneys treated with allopurinol before transplantation.


Renal allograft prolongation after graft perfusion with heterologous antilymphocyte globulin.


Survival of canine renal allografts after treatment with polyspecific F(ab')2 fragments.


An assay based on cell-mediated cytotoxicity for detection of presensitized recipients.


Immunosuppressive effect of Ecteinascidia turbinata in mice.


Effect of lung transplantation on surfactant.


Structural and metabolic changes in "preserved" renal allografts.


Effect of BCG and Corynebacterium Parvum on allograft survival after rabbit antimouse lymphocyte serum and donor bone marrow.


An in vitro approach to transplant rejection.


Prolonged survival after orthotopic liver transplantation in inbred rats.


Use of immunological enhancement in skin transplantation in burns.


Polyphosphate 99m-Tc scans: a quantitative method for evaluating clinical bone formation rates.


Use of small computers in solution of clinical problems.


PO2, Pco2, pH, lactate, and pyruvate levels in venous effluent blood during construction bipedicle flaps.


Hydrogen fluoride burns: experiments and treatment.


Experimental induction of epithelialization of the anterior chamber.


Hormonal enhancement of autologous onlay bone grafts.


Pathways of 3-H-collagen loss from skin grafts.


Effect of injury, repair, and ascorbic acid deficiency on collagen accumulation in peripheral nerves.


The vascularization of the porcine xenograft.


Hemodynamic and respiratory responses of conscious swine to Escherichia coli endotoxin.


Cellular components of renal lymph during allograft rejection: effect of immunosuppression.


Detection of detoxified endotoxin by the Limulus lysate assay.


A century of ophthalmology at the University of Pennsylvania.


A silver anniversary for Elliott H. Morse.


Pimozide in tardive dyskinesia.

Pimozide in tardive dyskinesia.


Percival Bailey 1892-1973.

Percival Bailey 1892-1973.


Treatment of vascular hemichorea and hemiballismus with perphenazine.


George Holman Bishop 1889-1973.

George Holman Bishop 1889-1973.


Norman M. Dott 1897-1973.

Norman M. Dott 1897-1973.


Frank Fremont-Smith 1895-1974.

Frank Fremont-Smith 1895-1974.


George D. Gammon 1902-1974.

George D. Gammon 1902-1974.


Ralph Waldo Gerard 1901-1974.

Ralph Waldo Gerard 1901-1974.


Lawrence S. Kubie 1896-1973.

Lawrence S. Kubie 1896-1973.


Hans H. Reese 1891-1973.

Hans H. Reese 1891-1973.


1874 - 1884: a memorable decade in the history of British neurology.


Modern face and cephalometry.

Modern face and cephalometry.


Differential diagnosis of pseudo Class III malocclusion by clinical and cephalometric appraisal.


Rapid palatal expansion: A recommmended prerequisite to Class III treatment.


Cleft palate symposium prothetist's contribution.


The influence of periosteoplasty on dental orthopaedics.


William H. Feldman 1892-1974.

William H. Feldman 1892-1974.


Tracheal basement membrane thickening in rhesus monkeys.


Naxogin in trichomonas vaginalis--a clinical trial with epidemiologic study.


[Radioimmunological assay of testosterone and gonadotropins in plasma and seminal fluid of healthy subjects and patients with dysspermia].