Glucocorticoid uptake and release by the human heart: studies at rest, during prolonged exercise, and during nicotinic acid infusion.


Comparison between a new chromogenic  -amylase test (Phadebas) and the Wohlgemuth amyloclastic method in urine.


15 N-studies in severe renal failure. I. Influence of amino acid administration on the nitrogen metabolism.


15 N-studies in severe renal failure. II. Evidence for the essentiality of histidine.


Protein-bound calcium in human serum. Quantitative examination of binding and its variables by a molecular binding model and clinical chemical implications for measurement of ionized calcium.


The normal region--a multivariate problem.


Selection of patients with cirrhosis of the liver for shunt surgery.


Radioimmunoassay of gastrin with activated charcoal.


Studies on the defecation relfex in man.


The double pylorus.

The double pylorus.


Choleresis induced by secretin: distinctly increased response in cirrhotics.


Absorption of fructose as measured by portal catheterization.


Absorption of maltose as measured by portal catheterization.


Intestinal metaplasia in experimental atrophic gastritis. Sucrase activity in the gastric mucosa of guinea-pigs after stomach irradiation.


The inhibitory effect of sulpiride on pentagastrin-stimulated gastric secretion.


The effect of methacholine on the pancreatic duct of the cat studied with a radiological method.


The effect of sulpiride on gastric motility.


Effect of chewing gum on gastric acid secretion.


Active chronic hepatitis: use of bromosulphthalein Tm and S in estimating disease activity.


A modification of the apomorphine dumping test.


Splenectomy in active chronic hepatitis.


Dose-response curves for acid output to histamine and pentagastrin determined by two techniques.


Terbutaline in bronchial asthma. Effect on lung volumes, ventilatory performance, pulmonary gas exchange and circulation at rest and during exercise.


Pulmonary tuberculosis in well-treated alcoholics. Long-term prognosis regarding relapses compared with non-alcoholic patients.


The MRC-ECCS questionnaire on respiratory symptoms (use in epidemiology).


Slowly sedimenting infectious entities of southern bean mosaic virus.


Aphid transmission characteristics of pea enation mosaic virus acquired from a membrane-feeding system.


The tryptic peptides and terminal sequences of the protein from the cowpea strain of tobacco mosaic virus.


Effect of infection with TMV and other viruses on the level of a  -1,3-glucan hydrolase in leaves of Nicotiana glutinosa.


Mitochondrial content and respiration in leaves with localized virus infections.


Heterogeneity in the poly(A) content of the genome of Sindbis virus.


Two new isolates of the satellite of tobacco ringspot virus.


The nucleotides at the RNA-DNA joint formed by the DNA polymerase of Rauscher leukemia virus.


Phosphorylated polypeptides in adenovirus-infected cells.


Human pharmacokinetics of a sulfamethoxazole-trimethoprim combination.


Hepatic encephalopathy evaluated by automatic period analysis of the electroencephalogram during lactulose treatment.


Fatty acid composition of serum lipids in men with myocardial infarction.


Plasma 11-hydroxycorticosteroids in acute myocardial infarction.


Fatty acid composition of serum lipids in wives of men with myocardial infarction.


Anxiety, growth hormone and glucose tolerance in normal children.


Cardiovascular complications in malignant thymoma with remarks on pulmonary hypertension.


Effect of adaptation to histamine and epinephrine on hyperfibrinogenaemia induced by histamine and epinephrine.


Recurrent pulmonary embolism--incidence, predisposing factors and prognosis.


Biological effect of basic polyglutamic acid derivatives.


Microcirculation, oxygen consumption, glucose metabolism and ion exchange in the kidney in haemolytic shock, with and without arterial hypotension.


Learning and memory as a function of age and food deprivation in young rats.


Diabetogenicity of ketoheptoses. II. Relative potencies.


Diabetogenecity of ketoheptoses. 3. Modification of structure.


Changes of the redox potential of NK-Ly tumour cells after DBD (1,6-dibromo-1,6-dideoxy-dulcitol) treatment.


Correlations between the medium's redox potential and the types of acetylcholine and adrenaline effect. I.


Retinocryopexy by 3-mirror contact lens.


Diabetic retinopathy and salicylates.

Diabetic retinopathy and salicylates.


Orbital cellulitis and cavernous sinus thrombosis caused by rhabdomyosarcoma of the middle ear.


Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Over a 5-month period during the winter of 1970-71, 20% of the lactating Holstein cows in a Wisconsin dairy herd died after prolonged ingestion of a diet containing 60% moldy corn infested with Fusarium tricinctum (2 x 10(5) propagules per g of moldy corn). Ethyl acetate extracts of the ground dried corn induced severe dermal reactions when applied to the skin of shaved 60-g albino rats and killed four of five 100-g rats that were force fed 1 ml in 2 ml of pure corn oil. T-2 toxin (3-hydroxy-4, 15-diacetoxy-8-[3-methylbutyryloxy]-12, 13-epoxy-Delta(9)-trichothecene) at concentrations of 2 mg per kg of dry corn was identified in purified extracts of the moldy corn by means of gas-liquid chromatography and mass spectrometry. This concentration of T-2 toxin in the moldy feed and the nature of the toxic effects observed strongly suggest a major causal relationship.


Cultural characteristics of a cell line derived from an equine sarcoid. A cell line, derived from a spontaneous equine connective tissue tumor (equine sarcoid), has been established. The morphological and growth characteristics indicative of malignant transformation of the cells include a disoriented, rapid growth and loss of contact inhibition. Further evidence of transformation is the agglutination of these cells by concanavalin A and their ability to divide in semisolid media.


Effect of sodium polyanetholesulfonate on antimicrobial systems in blood. Sodium polyanetholesulfonate (SPS), an anticoagulant which inhibits the antimicrobial systems of blood, is used widely in blood culture media. The addition of SPS to experimental blood cultures inoculated with small numbers of a variety of organisms caused a striking increase in recovery of these organisms. Sodium fluoride also increased the incidence of positive blood cultures with some organisms. SPS completely inhibited serum antibacterial activity and serum-dependent phagocytosis (and killing) by isolated leukocytes at a concentration usually employed in blood culture media. SPS also stimulated both glucose C-1 oxidation in resting leukocytes and formate oxidation in both resting and phagocytosing leukocytes in serum-free systems. These in vitro studies support the concept that SPS is a useful additive to blood culture media and further elaborate on the mechanism of its inhibition of the microbicidal activity of blood.


Degradation of chlorbromuron and related compounds by the fungus Rhizoctonia solani. The ability of the soil fungus Rhizoctonia solani to degrade phenyl-substituted urea herbicides was investigated. The fungus was able to transform chlorbromuron [3-(3-chloro-4-bromophenyl)-1-methyl-1-methoxyurea] to the demethylated product [3-(3-chloro-4-bromophenyl)-1-methoxyurea], which was isolated and identified. Evidence was obtained that further degradation of chlorbromuron occurred. Several other phenylurea compounds (chloroxuron, diuron, fenuron, fluometuron, linuron, metobromuron, neburon, and siduron) were also metabolized by the fungus, indicating that R. solani may possess a generalized ability to attack this group of herbicides.


pH-dependent polyol production in Moniliella tomentosa. Production of polyols by the yeastlike fungus Moniliella tomentosa could be increased by growing the organism at constant low pH. Up to 54% increase in yield was obtained. Growth at low pH also results in the production of D-arabitol which is not found in normal media.


Isolation of a new soluble antigen from the yeast phase of Histoplasma capsulatum. A method is described by which a soluble antigen was prepared from the yeast phase of Histoplasma capsulatum. This soluble preparation had a specificity greater than that of whole-cell yeast-phase antigens. In complement fixation tests with sera from human cases of histoplasmosis, blastomycosis, and coccidioidomycosis, the soluble antigen reacted in 12.1% of 141 tests with heterologous sera, whereas conventional whole-cell yeast antigens reacted in 47.3% of 91 tests with heterologous sera. The reactivities of the two types of antigens with homologous sera were essentially the same.


Evaluation of plastic multi-well plates for serological screening of Salmonella cultures with Spicer-Edwards pooled antisera. We compared the relative advantages of using glass test tubes and plastic multi-well plates in the serological identification of Salmonella cultures by the Spicer-Edwards method, and we conclude that the advantages of multi-well plates outweigh those of test tubes.


Vitamin A adjuvant with Arizona hinshawii bacterin. Vitamin A provided adjuvant effect for Arizona hinshawii bacterin in protection of Coturnix quail against severe challenge.


The recognition of simple and complex realistic figures in patients with unilateral brain lesion.


Redistribution of cardiac output during liquid breathing in the newborn rabbit.


Silver deposition in rat glomerular basement membrane.


Absorption and endogenous production of immunoglobulins in calves.


Species variation in galactokinase activity of erythrocytes, lens and liver.


Distribution of the work force of members of the Australian Veterinary Association.


The action of clonidine on isolated arterial preparations.


Ovine cysticercosis and canine taeniasis in Victoria.


Transmission of Anaplasma marginale by the cattle tick Boophilus microplus.


Isolation of an adenovirus from an Arab foal.


Suspected Pasteurella anatipestifer infection in ducklings in New South Wales.


Heliotropium poisoning in cattle.

Heliotropium poisoning in cattle.


N-Ethylmaleimide labeling of a phlorizin-sensitive D-glucose binding site of brush border membrane form the rat kidney.


Inhibition of ( 3 H)phlorizin binding to isolated kidney brush border membranes by phlorizin-like compounds.


Separation of glomerular basement membrane substances by sodium dodecylsulfate disc gel electrophoresis and gel filtration.


Laser-Raman spectroscopic study of egg lecithin and egg lecithin-cholesterol mixtures.


Tetraethylammonium ion inhibition of potassium conductance of the nodal membrane.


The cooperative character of phenylalanine binding by a protein fraction isolated from baker's yeast membranes.


Hydrolysis of alanine oligopeptides by an enzyme located in the membrane of Mycoplasma laidlawii.


Perturbation of red cell volume. Determination of membrane transport parameters for rapid penetrants.


Anion diffusion across artificial lipid membranes: the effects of lysozyme on anion diffusion from phospholipid liposomes.


On the mechanism of acetate enhancement of renal p-aminohippurate transport.


Evidence for specific transport mechanisms for aromatic compounds in bacterium N.C.I.B. 8250.


Differences between conformations of lecithin and phosphatidylethanolamine polar groups and their effects on interactions of phospholipid bilayer membranes.


A simple method of determining relative permeabilities of liposomes to nonelectrolytes.


Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface.


Bursicon: its effect on tyrosine permeation into insect haemocytes.


Selected lipid monolayers on aqueous-glycerol and aqueous-urea substrates.


Control of nonelectrolyte permeability in red cells.


Insulin binding to plasma membranes.

Insulin binding to plasma membranes.


Membrane changes in HeLa cells grown with cortisol.


Quantitative aspects of the urinary and fecal excretion of radioactive metabolites of vitamin A in the rat.


Human skeletal muscle phosphorylase activities with exercise and training.


Concerning the problem of granular disintegration in experimental cardiomyopathies.


Cardiovascular effects of propranolol during acute experimental anemia in dogs.


Excretion of sulfinpyrazone in the rat.

Excretion of sulfinpyrazone in the rat.


The effect of injecting an inert oil into the cerebral ventricular system upon fever produced by intravenous leucocyte pyrogen.


Aortic reactivity of rats with genetic and experimental renal hypertension.


Action of some centrally active drugs and heavy metals on in vitro oxidation of dopamine by rat brain tissue.


The mechanism of acute neuromuscular weakness induced by chloroquine.


Calcium inward currents in insect muscle fibers.


Some metabolic effects of a single dose of crystalline dihydrotachysterol.


Similarity between effects of general anesthetics and dinitrophenol on cortical neurones.


Equality before the law.

Equality before the law.


Learning disability.

Learning disability.


Kinky hair and copper.

Kinky hair and copper.


Expensive switch.

Expensive switch.


Arrival of Uganda Asians.

Arrival of Uganda Asians.


Preliminary clinical studies with L-prolyl-L-leucyl-glycine amide in Parkinson's disease. The present study, carried out in 16 parkinsonian patients, indicates that L-prolyl-L-leucyl-glycine amide possesses some antiparkinsonian activity and that, if used with levodopa, it can reduce some of the drug-induced dyskinesias. These preliminary observations should be submitted to a controlled trial in a large number of patients before therapeutic applications are claimed.


Mechanography: a non-invasive technique for the evaluation of cardiac function in children. Experience in the pediatric age group with mechanography, an indirect method of cardiovascular investigation, is described with emphasis on the recording technique and on the analysis of the tracings. A few examples are presented with comments on the morphological aspects and the time characteristics of the pulse curves, showing how much information about cardiac disease and especially myocardial function in children may be obtained.


Surgical treatment of abdominal aortic aneurysms in Toronto: a study of 1013 patients.


Reactivity of human lymphocytes to aggregated and nonaggregated PPD-tuberculin.


Delayed hypersensitivity to azobenzenearsonate amino acids conjugates. In vitro study of the specificity of the immune response by  3 H-thymidine incorporation into lymph node cells.


Regulation of the immune response by antibody. II. The effects of different classes of passive guinea pig antibody on humoral and cell-mediated immunity in rats.


The characteristics of lymphocyte tritiated thymidine incorporation in response to mumps virus.


Investigation of serum alkaline phosphatase in skeletal and hepatobiliary disease.


A comparison of two methods for the determination of serum ionic calcium.


Observations on diagnostic kits for the determination of chloride.


Rapid identification of and assessment of damage by inhaled volatile substances in the clinical laboratory.


Xylose absorption test using D-xylose- 14 C.


A quantitative micro technique for the analysis of lead in blood by carbon rod atomization and atomic absorption spectrophotometry.


The significance of cancer research.

The significance of cancer research.


Goltz's syndrome: focal dermal dysplasia syndrome (focal dermal hypoplasia): report of a case and on its etiology and pathogenesis.


Hyalinosis cutis et mucosae: regenerative properties of tissues involved in chronic pathology.


Tne community dentist.

Tne community dentist.


Adrenal and pituitary functions during long-term topical steroid therapy.


Occupational health and hazards in the health service.


The community commitment of the general practitioner.


Education in environmental health.

Education in environmental health.


Some principles in the conduct of public health surveys.


The emergency ambulance service.

The emergency ambulance service.


The family-centred approach: a challenge to public health nurses.


Some pharmacological effects of phenitrone and its interaction with   9 -THC.


The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine.


Route of administration and drug metabolism.


Thyroid action on behavioral-physiological effects and disposition of phenothiazines.


The effect of calcium and magnesium ions on drug-receptor interactions.


Effects of catecholamines on the AV nodal pacemaker in situ after destroying the SA node.


Absorption rates of some cardiac glycosides and portal blood flow.


Acute and chronic effects of hydrochlorothiazide on vascular adrenergic mechanisms.


Effects of nicotine, carbon monoxide and tobacco smoke on regional blood flow in the cerebral cortex.


Anti-gastric acid secretory effect of phenformin--a preliminary report.


5,6-Dihydroxyindole formation from oxidized 6-hydroxydopamine.


The effect of iodoacetate on the retinal cell DNA in rabbit.


Ultrastructure of the avian retina. An anatomical study of the retina of the domestic pigeon (Columba liva) with particular reference to the distribution of mitochondria.


The development of the sphincter muscle in the iris of the albino rat.


The development of the dilator muscle in the iris of the albino rat.


Low molecular weight protein ( -crystallin) in the lens of birds.


Effect of oxygen on the developing retinal vessels of the rabbit. I. Anatomy and development of the retinal vessels of the rabbit.


Intraocular fluid dynamics. 3. The site and mechanism of prostaglandin transfer across the blood intraocular fluid barriers.


On the hydration of  -crystallin of bovine lenses.


Errors in eye tissue temperature measurements when using a metallic probe.


An evaluation of the homeostatic mechanism in tonography.


The origin of urea-insoluble protein isolated from rat lens.


To the question of water and urea-insoluble residue of the lens.


Distribution of Na + , K +  and free amino acids in lenses of sheep with erythrocytes containing high and low potassium.


The effect of light on lens proteins in vitro.


Developmental changes in the rate of oxygen consumption in egg vesicles of Galleria mellonella (Lepidoptera).


An autoradiographic study of the synthesis of nucleic acids and protein during the cell cycle of synchronously dividing antheridial filaments in Chara vulgaris L.


Glucagon, physiological and pharmacological aspects.


A comparative study of radiological and morphometric determinations of bone density in patients with renal osteodystrophy.


Initial experience with sigmoido-coloscopy.


Excretion of bilirubin pigments by the kidney.


Short stature, mental retardation and ocular alterations in three siblings.


Clinical heterogeneity of erythrocyte pyruvate kinase deficiency. Evidence of an impaired utilization of ATP in a clinically severe form.


Primary cystathioninuria. Methionine load tests and response to pyridoxine.


Hyperphagia, obesity and diabetes insipidus due to hypothalamic lesion in a girl.


Hernia economics.

Hernia economics.


Stomach carcinoma and the gastrocamera.

Stomach carcinoma and the gastrocamera.


Problems in the diagnosis, treatment and prevention of intrauterine adhesions.


Carcinoma of the gallbladder with perforation.


Desmoid tumors of the bone.

Desmoid tumors of the bone.


Tumors of the brain and its coverings. An African series.


Intestinal obstruction due to a foreign body complicating ischemic ileitis.


Rupture of the long head of the biceps tendon. A relative surgical emergency.


Psychosomatic disturbances following hysterectomy performed at a premenopausal age.


Brenner's tumor with malignant degeneration.


Hydrocolpos: a cause of urinary obstruction.


Observation of the dissociation of unliganded hemoglobin.


Glucocorticoid-binding proteins of rat liver cytosol. I. Separation and identification of the binding proteins.


The binding of manganese-nucleoside diphosphates to creatine kinase as determined by proton relaxation rate measurements.


Glucocorticoid-binding proteins of rat liver cytosol. II. Physical characterization and properties of the binding proteins.


On the role of copper in activation of and catalysis by tryptophan-2,3-dioxygenase.


Primary structures of the proinsulin connecting peptides of the rat and the horse.


Peptide analysis of the mouse hemoglobin messenger ribonucleic acid-directed products synthesized in mammalian and avian cell-free systems.


Variation of deoxyribonucleic acid polymerase activities during rat liver regeneration.


Progesterone binding in uterine cytosols of the guinea pig.


Isolation of a cysteine-peptide at the active site of histidine ammonia-lyase.


Kinetics of enzymatic modification of the protamines and a proposal for their binding to chromatin.


Mechanism of action of the flavoenzyme lactate oxidase.


Oxidation of branched chain amino acids by isolated hearts and diaphragms of the rat. The effect of fatty acids, glucose, and pyruvate respiration.


Mechanism of action of pyruvate kinase. Role of sulfhydryl groups in catalytic activity as determined by disulfide interchange.


Regulation of enzymatic activity through subunit interaction. A possible example.


Spectral assignment and conformational analysis of cyclic peptides by carbon-13 nuclear magnetic resonance.


Aldehydes as inhibitors of papain.

Aldehydes as inhibitors of papain.


Improvement in myocardial function and coronary blood flow in ischemic myocardium after mannitol. The purpose of this study was to evaluate the effect of hyperosmolality on the performance of, and the collateral blood flow to, ischemic myocardium. The myocardial response to mannitol, a hyperosmolar agent which remains extracellular, was evaluated in anesthetized dogs. Mannitol was infused into the aortic roots of 31 isovolumic hearts and of 15 dogs on right heart bypass, before and during ischemia. Myocardial ischemia was produced by temporary ligation of either the proximal or mid-left anterior descending coronary artery. Mannitol significantly improved the depressed ventricular function curves which occurred with left anterior descending coronary artery occlusion. Mannitol also significantly lessened the S-T segment elevation (epicardial electrocardiogram) occurring during myocardial ischemia in the isovolumic hearts and this reduction was associated with significant increases in total coronary blood flow (P < 0.005) and with increased collateral coronary blood flow to the ischemia area (P < 0.005).THUS, INCREASES IN SERUM OSMOLALITY PRODUCED BY MANNITOL RESULT IN THE FOLLOWING BENEFICIAL CHANGES DURING MYOCARDIAL ISCHEMIA: (a) improved myocardial function, (b) reduced S-T segment elevation, (c) increased total coronary blood flow, and (d) increased collateral coronary blood flow.


The renal functional defect of postobstructive nephyropathy. The effects of bilateral ureteral obstruction in the rat. This study was designed to examine the pathogenesis of the excretory defect produced by bilateral ureteral obstruction in the rat. After release of obstruction of 24 hr duration glomerular filtration rate was reduced to 20% of normal. Free flow proximal tubular pressure was normal, excluding residual obstruction as a cause of depressed filtration, and indicating that an intrarenal hemodynamic abnormality was primarily responsible for the excretory defect. Total renal blood flow and cortical distribution of flow were normal. Clearance and micropuncture studies indicated the presence of marked heterogeneity of nephron function with residual excretory function residing primarily in vasodilated nephrons in which decreased postglomerular arteriolar resistance effected a reduction in glomerular filtration pressure. Heterogeneity of nephron function was evidenced by a wide scatter of values for single nephron filtration rate and from direct intratubular injection of dye which revealed that at least 28% of surface nephrons were either nonfiltering or had filtration rates too low to measure. The observed decrease in Hippuran extraction and increased ratio of Hippuran to inulin clearance ratio is characteristic of the vasodilated kidney. Further evidence of the vasodilated nature of residual functioning nephrons was demonstrated by the failure of intrarenal papaverine infusion to increase filtration rate in this lesion. The hemodynamic defect produced by bilateral obstruction is contrasted with that seen after release of unilateral ureteral ligation in which depression of filtration rate appears to result primarily from preglomerular vasoconstriction. This difference raises the possibility that a vasodilating substance accumulates during total suppression of renal excretory function. Diuresis and natriuresis were constant features of the postobstructive lesion. The present data support previously published studies which localize the defect in sodium transport to the distal nephron and indicate that this defect is a consequence of increased intraluminal pressure and tubular dilatation induced by bilateral ureteral ligation.


Effect of rheumatoid factor on complement-mediated phagocytosis. The frequency and amount of IgM rheumatoid factor (RF) in the blood of patients with rheumatoid arthritis (RA) correlate with the severity of the disease and the number of complications. Though previous studies of RF in subacute bacterial endocarditis have shown that RF inhibits phagocytosis of microorganisms by granulocytes, the presence of low levels of complement (C) in blood and synovial fluid of patients with the highest titers of RF suggests that an interaction between RF and C may contribute to the inflammatory process in RA. We thus employed a quantitative methodology to examine the effect of RF on complement-dependent phagocytosis of sheep erythrocytes by rabbit granulocytes. Addition of 2500 molecules of IgM RF to sheep cells heavily coated with IgG antibody (195,000 molecules per cell) resulted in virtually complete inhibition of uptake of C3 (beta(1c)) and prevention of phagocytosis, an effect resulting from inhibition of uptake of C1 by the cells. When erythrocytes coated with only 34,000 molecules of IgG antibody were employed, phagocytosis was similarly inhibited. However the effect of RF on such cells was shown to be primarily mediated through inhibition of C4 rather than C1 uptake. Although the results do not exclude the participation of an IgM RF of higher avidity, present only in the tissues in rheumatoid inflammation, circulating IgM RF probably does not play a potentiating role in rheumatoid inflammation.


The role of iron in the pathogenesis of porphyria cutanea tarda. An in vitro model. Porphyria cutanea tarda (PCT) is characterized biochemically by excessive hepatic synthesis and urinary excretion of uroporphyrin I. Clinical evidence has implicated iron in the pathogenesis of PCT. The synthesis of the normally occurring isomer of uroporphyrin, namely uroporphyrin III, from porphobilinogen (PBG) requires two enzymes; uroporphyrinogen I synthetase and uroporphyrinogen III cosynthetase (COSYN). In the absence of COSYN only uroporphyrinogen I is formed. These experiments were designed to study the effect of iron on porphyrin biosynthesis in porcine and human crude liver extracts and to measure COSYN activity in the presence of iron.Mitochondria-free crude liver extracts were prepared in 0.25 m sucrose at pH 7.4 by centrifugation at 37,000 g. Preparations were incubated with either 0.2 mm amino-levulinic acid (ALA) or 0.1 mm PBG. The addition of ferrous ion (either from ferritin iron [4 mug/ml] and cysteine [6.7 mm] or ferrous ammonium sulfate [0.3 mm Fe] and cysteine) significantly increased the rate of uroporphyrin synthesis from either ALA or PBG. The predominant porphyrin synthesized in the presence of ferrous ion was uroporphyrin I whereas coproporphyrin III predominated in its absence. Orthophenanthroline blocked these effects of ferrous ion.To investigate the effect of ferrous ion on COSYN, crude liver extracts were incubated with ferrous ammonium sulfate (0.3 mm Fe) and cysteine (6.7 mm) and the COSYN activity of the incubates was assayed directly. In both porcine and human extracts ferrous ion caused marked inhibition of COSYN activity. Orthophenanthroline blocked the inhibitory effect.Inactivation of COSYN by heating resulted in marked enhancement of porphyrin synthesis from PBG. The sole product was uroporphyrin I.Thus, inactivation of COSYN results in accelerated synthesis of uroporphyrin I. This effect of ferrous ion provides a possible biochemical explanation for the excess production and excretion of uroporphyrin I in patients with PCT and the reversal of this defect by phlebotomy.


Left ventricular response to severe exertion in untethered dogs. The left ventricular response to severe exercise was studied by telemetering direct measurements of left ventricular diameter (D) and pressure (P) and aortic blood flow from healthy dogs running at speeds up to 30 mph in the field. Severe exercise increased cardiac output from 101 to 478 ml/kg per min, heart rate from 95 to 297 beats/min, stroke volume from 31 to 44 ml, left ventricular isolength (iso) systolic pressure from 120 to 186 mm Hg, left ventricular end diastolic pressure from 6 to 18 mm Hg, and left ventricular end diastolic diameter from 58.9 to 60.1 mm, while end systolic diameter decreased from 53.0 to 52.2 mm. Two indices of myocardial contractility, (dP/dt)/P increased from 37 to 92 sec(-1), while dD/dt, the velocity of myocardial fiber shortening at isolength, rose from 54 to 119 mm/sec. All of these changes were statistically significant. When, in resting dogs, heart rate was first raised to exercise levels by electrical stimulation, severe exercise subsequently increased left ventricular end diastolic diameter more profoundly, from 55.7 to 59.7 mm, while end systolic diameter remained constant and the increases in left ventricular pressure, (dP/dt)/P and velocity(iso) were roughly comparable to those occurring during exercise in spontaneous rhythm. After propranolol, 1.0 mg/kg, severe exercise resulted in significantly smaller increases in cardiac output (from 82 to 240 ml/kg), in heart rate (from 87 to 186 beats/min), in left ventricular pressure(iso) (from 122 to 150 mm Hg), in (dP/dt)/P (from 32 to 44 sec(-1)), in velocity(iso) (from 47 to 59 mm/sec), and in slightly greater increases in end diastolic diameter, from 59.8 to 62.0 mm and pressure from 8 to 22 mm Hg, while end systolic diameter did not change significantly.Thus, the left ventricle responds to severe exercise with near maximal increases in heart rate and contractility, while significant increases in end diastolic diameter (Frank-Starling mechanism) and stroke volume occur as well. When heart rate was held constant severe exercise produced similar increases in contractility but end systolic size failed to diminish and the increases in end diastolic size were greater. Beta adrenergic receptor blockade interfered with the chronotropic and particularly the inotropic response to severe exercise and while the participation of the Frank-Starling mechanism was somewhat greater, the latter was not sufficient to increase cardiac output normally.


Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. Hepatic secretions of biliary lipids were estimated in 43 patients with and without cholesterol gallstones. Studies were carried out by a marker dilution technique employing duodenal intubation with a three-lumen tube. Hourly secretion rates of cholesterol, bile acids, and phospholipids were determined during constant infusion with liquid formula. In 17 American Indian women with gallstones, hourly outputs of biliary bile acids were significantly less than those in 7 Indian men and 12 Caucasian women without gallstones. These findings suggest that a decreased hepatic secretion of bile acids contributes significantly to the production of a lithogenic bile in Indian women. However, in Indian women with gallstones, secretion of biliary cholesterol was also significantly increased, as compared with Caucasian women without stones. Therefore, lithogenic bile in Indian women was, in most cases, due to a combined decrease in bile acid output and increase in cholesterol secretion. In an attempt to determine the mechanisms for these abnormalities, cholesterol balance studies were done in Indian women with gallstones and normal Indian men. Balance data were compared with results reported previously in non-Indian patients studied by the same techniques, and in general, Indian women showed a slight increase in fecal excretion of bile acids. Since bile acids in the enterohepatic circulation were relatively depleted in Indian women, these patients had a reduced fractional reabsorption. However, previous studies have shown that Caucasians can rapidly replenish bile acid pools in the presence of much greater intestinal losses, and it is suggested that among Indian women with gallstones, reduced secretion rates of bile acids are primarily the result of defective homeostatic regulation of bile acid synthesis. In Indian women with gallstones, at least two factors may have contributed to an increased availability of cholesterol in the liver for secretion into bile. First, cholesterol was inadequately converted into bile acids, and secondly, an increased amount of cholesterol was synthesized, as shown by the balance technique. This enhanced production of cholesterol can partially be explained by obesity, but other factors may also play a role.


Free fatty acid metabolism of leg muscles during exercise in patients with obliterative iliac and femoral artery disease before and after reconstructive surgery. The free fatty acid (FFA) uptake and oxidation and the carbohydrate substrate exchange of leg muscles were studied during exercise in 14 patients with occlusive disease of the iliac or femoral arteries before and 3-6 months after reconstructive vascular surgery and in 5 healthy subjects. (14)C-labeled oleic acid was infused continuously at rest and during exercise at work loads of 150-400 kg-m/min. The arterial concentration of FFA was similar both at rest and during exercise in patients and controls. The patients showed a smaller increase in the fractional turnover of FFA during exercise. Leg uptake and release of FFA in terms of micromoles per liter plasma did not differ significantly either at rest or during exercise between patients and controls. FFA oxidation could not be measured at rest but exercise data showed a lower fractional oxidation of FFA (P < 0.001) in the patient group (53+/-6%) compared with the controls (84+/-2%). For the entire material, fractional oxidation of FFA showed a significant negative regression on the lactate/pyruvate ratio in femoral venous blood. The ventilatory respiratory quotient (RQ) and the leg muscle exchange of glucose and lactate in the patients exceeded that of the controls. When six patients were studied after reconstructive surgery, fractional oxidation of FFA had risen from a preoperative value of 47+/-8 to 90+/-10%, other data for leg muscle FFA metabolism being unchanged. IT IS CONCLUDED: (a) that substrate catabolism by the leg muscles during exercise in these patients proceeds in excess of the simultaneous capacity to oxidize acetyl-CoA in the tricarboxylic acid cycle, and (b) oxidation of FFA by contracting muscle is related to the muscle cell redox state.


Effect of experimental chronic renal insufficiency on bone mineral and collagen maturation. The effect of chronic renal disease on bone matrix and mineral maturation was evaluated in rats with experimental renal insufficiency of 2-11 wk duration utilizing bromoform-toluene gradient fractionation of bone powder, pulse labeling experiments with (45)Ca and proline-(3)H differential extraction, and X-ray diffraction techniques.Maturation defects in both collagen and mineral ((45)Ca) metabolism were documented as early as 2 wk after the induction of uremia, when total bone calcium, inorganic phosphate, and hydroxyproline content were unchanged. The maturational defect progressed with advancing uremia despite insignificant changes in plasma pH and calcium, and normal bone carbonate levels. Although circulating levels of 25-hydroxycholecalciferol were significantly lower than normal in the uremic animals, pretreatment with either this vitamin D metabolite or vitamin D(3) itself failed to alter the observed changes in skeletal maturation.


Effects of elevated glucose concentrations on the metabolism of the aortic wall. The effects of elevated glucose concentrations on the metabolism of the aortic wall were examined in a preparation of tubular segments of rabbit descending thoracic aorta comprised of intima and media only. Increased medium glucose concentrations (20-50 mm) resulted in increased aortic sorbitol and fructose concentrations and an increased rate of fructose release into the medium. This increased flux through the polyol pathway can be explained as a consequence both of an increased free intracellular glucose concentration and of the kinetic characteristics of the alditol: NADP oxidoreductase and the l-iditol: NAD oxidoreductase isolated and partially purified from rabbit thoracic aorta. Incubation with elevated glucose concentrations for 2 or more hr was also associated with a significant increase in the water content of the tissue without a significant increase in the inulin space. The oxygen uptake of the tissues incubated with elevated glucose concentrations was significantly reduced; this appears to result from a limitation imposed by oxygen diffusion at physiological oxygen tensions. A compensatory increase in glycolysis and an increase in the aortic lactate/pyruvate concentration ratio were also observed. The oxygen uptake and lactate production of tissue incubated with 50 mm glucose could be preserved at rates observed in tissue incubated with a physiological glucose concentration by the addition of 40 mm mannitol to the medium. Aortic intima and media from alloxan-diabetic rabbits also exhibit an increased water content and a decreased rate of oxygen uptake. These observations suggest that elevated ambient glucose concentrations result in significant alterations in the metabolism of aortic intima and media.


Lymphocyte transformation induced by autologous cells: stimulation by cultured lymphoblast lines. The ability of cultured lymphoblasts to stimulate autologous lymphocyte transformation in "one-way" mixed leukocyte culture has been studied. Intact, cultured lymphoblasts required physical contact with responding lymphocytes to induce transformation. In quantitative terms, lymphocytes incorporate as much thymidine when mixed with irradiated cultured lymphoblasts as they do in response to phytohemagglutinin. The stimulation of lymphocyte transformation by allogeneic cultured lymphoblasts did not parallel the stimulation of lymphocyte transformation by leukocytes from the donor of the lymphoblast culture. The stimulatory determinants on the cultured lymphoblast are unaffected by neuraminidase but destroyed by trypsin. The trypsin-treated cultured lymphoblasts regain their capacity to stimulate autologous lymphocyte transformation within 48 hr in culture. Cultured lymphoblasts possess concanavalin A binding sites. Concanavalin A inhibits the capacity of cultured lymphoblasts to stimulate autologous lymphocyte transformation. The relevance of these findings to EB virus infection of cultured lymphoblasts and to immune surveillance is discussed.


Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone. A constant withdrawal pump was used to determine the integrated concentration of growth hormone (ICGH) which was used in conjunction with the metabolic clearance rate (MCR) of growth hormone (GH) to calculate the GH production rates (GHPR) in normal adults, acromegalics, and normal controls receiving prednisone. The mean ICGH for 22 premenopausal females on no medication was 3.0+/-1.6 ng/ml (sd) which is significantly lower (P < 0.005) than the mean of 6.6+/-2.9 for 10 women receiving oral contraceptives and significantly higher than the means of 1.5+/-0.75 for 5 postmenopausal females (P < 0.05) and 1.8+/-1.0 for 16 adult males (P < 0.01) which are comparable. The mean GHPR's in mg/24 hr per m(2) for the four groups are: normal females = 0.52+/-0.24 (sd), females receiving contraceptive pills = 1.65+/-0.58 (P < 0.005), postmenopausal females = 0.26+/-0.12 (P < 0.025), and adult males 0.35+/-0.23 (P < 0.025).Three untreated acromegalic patients had ICGH's of 59, 82, and 93 ng/ml and GHPR's ranging from 14.5 to 17.9 mg/24 hr. Prednisone in a dose of 20 mg t.i.d. for 8 days significantly decreased both the ICGH and GHPR. Alternate day prednisone (60 mg in a single q.o.d. dose) resulted in less consistent inhibition of GH release which may play a role in the more normal growth seen in children receiving q.o.d. prednisone.


Studies of two subpopulations of human lymphocytes differing in responsiveness to concanavalin A. We have identified two populations of human lymphocytes differing in responsiveness to the plant mitogen concanavalin A (Con-A). When peripheral blood lymphocytes are passed through a nylon column a population of lymphocytes highly responsive to Con-A adheres to the fibers while a second population of cells relatively unresponsive to Con-A emerges from the column. The untreated peripheral blood lymphocytes are termed "unfiltered" cells while the lymphocytes which pass through the column are termed "filtered" cells. Under standard assay conditions the Con-A-stimulated DNA synthesis is 6.5-fold greater, and the percentage blast formation is four-to fivefold greater in the unfiltered than in the filtered population. Mixing unfiltered with filtered cells fails to induce responsiveness in the latter indicating that a "helper" cell is not involved. The failure of filtered cells to respond to Con-A is specific for that mitogen since both populations respond nearly equally to erythroagglutinating phytohemagglutinin (E-PHA) and the poke weed mitogen (PWM). Binding studies with Con-A-(131)I demonstrate that the unfiltered population possesses approximately three times as many Con-A receptor sites per cell as the filtered cells, although both cell populations bind the mitogen with the same affinity (apparent association constant [K] of 1.67 x 10(6)m(-1)). The relationship between Con-A binding and lymphocyte activation was determined by measuring the effect on DNA synthesis of incubating the two lymphocyte populations with increasing amounts of Con-A. The concentration of Con-A required for half-maximal stimulation of DNA synthesis was 5-14 times greater for the filtered cells. However in the presence of very high Con-A concentrations the filtered cells achieved a maximal rate of DNA synthesis approaching that of the unfiltered population. These data implicate the decreased number of Con-A receptor sites on the filtered cells in their failure to respond to low concentrations of Con-A. A crucial event in the activation of lymphocytes by plant mitogens may be the binding of a critical number of the mitogen molecules to the cell surface.


The Wiskott-Aldrich syndrome. Results of transfer factor therapy. 12 patients with Wiskott-Aldrich syndrome were treated with therapeutic doses of transfer factor in an attempt to induce cellular immunity. Clinical improvement was noted after transfer factor therapy in 7 of the 12 patients treated. Because this disease has a variable course and temporary spontaneous improvement can occur, the observed improvement cannot necessarily be attributed to the transfer factor. However, in two patients repeated remissions consistently followed transfer factor administration on repeated occasions. This included freedom from infections, regression of splenomegaly, and clearing of eczema. An unexpected finding was a decrease in bleeding in 3 of the 10 patients who had bleeding. Conversion of skin reactivity was obtained in all seven patients who clinically seemed to respond to transfer factor. In vitro studies performed after the administration of transfer factor demonstrated that the lymphocytes of the patients now produced migration inhibitory factor in response to appropriate test antigens, but did not undergo increased radioactive thymidine incorporation in response to the same antigens. A defect in the monocyte IgG receptors has been found in certain patients with the disease, and the current study shows that all patients with defective monocyte IgG receptors responded to transfer factor, whereas only one patient with normal receptors showed any response. This test may thus prove to be useful in predicting the results of transfer factor therapy in patients with Wiskott-Aldrich syndrome, although evaluation of a larger series of patients will be necessary to confirm this point. We conclude that cellular immunity can be induced, that there appears to be clinical benefit in certain patients with Wiskott-Aldrich syndrome by the use of transfer factor, and that this mode of therapy warrents trial in these patients and others with defects of cellular immunity.


Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture. Because maximum expiratory flow-volume rates in normal subjects are dependent on gas density, the resistance between alveoli and the point at which dynamic compression begins (R(us)) is mostly due to convective acceleration and turbulence. We measured maximum expiratory flow-volume (MEFV) curves in asthmatics and chronic bronchitics breathing air and He-O(2). In the latter and in some asthmatics, MEFV curves did not change, indicating that R(us) is mostly due to laminar flow. Therefore, the point at which dynamic compression begins must be further upstream than in normal subjects and the site of obstruction must be in small airways. In other asthmatics, flow increased normally indicating obstruction in larger airways. The response to He-O(2) did not correlate with initial values of pulmonary resistance, the initial MEFV curves or the response to bronchodilators. We conclude that the site of airway obstruction varies among asthmatics and that the site of obstruction is not detectable by measurement of the usual parameters of lung mechanics.


An analysis of lipoproteins, bile acids, and red cell membranes associated with target cells and spur cells in patients with liver disease. Most patients with stable cirrhosis of the alcoholic have "target" red cells; however, a minority have "spur" cells and severe hemolytic anemia. These two syndromes were studied in 27 patients with target cells and 17 patients with spur cells, all of whom had advanced cirrhosis. The cholesterol and phospholipid content of red cell membranes effectively distinguished target cells from spur cells. Target cells alone were rich in lecithin, and both the cholesterol/phospholipid and cholesterol/lecithin mole ratios were greater in spur cells. The cholesterol/phospholipid mole ratio of both types of red cells correlated closely with the free cholesterol saturation of serum lipoproteins, as defined by the amount of free cholesterol relative to phospholipid and protein in these lipoproteins. Lecithin: cholesterol acyltransferase (LCAT) activity was decreased in most patients with target cells and spur cells; however, the relationship between this activity and the lipid abnormalities observed was weak. Serum bile acid levels also correlated poorly with serum and cell lipids. However, in patients with target cells the amount of cholic and deoxycholic acids in serum was approximately equal to the amount of chenodeoxycholic acid, whereas in patients with spur cells chenodeoxycholic acid (the precursor of lithocholic acid) predominated.


Recoupling the Na-K pump.

Recoupling the Na-K pump. Human red blood cells display under appropriate circumstances a ouabain-sensitive K-K exchange when the flux measurements are made using radioisotopes. Such an exchange complicates measurements of the coupling of Na outflux to K influx in cells which are partially depleted of energy sources by deprivation of glucose since the K-K exchange has been found to be increased in depleted cells. When the measurements of flux are made by estimating net cation movements chemically, it is found that glucose deprivation results in a fall in both ouabain-sensitive Na outflux and ouabain-sensitive K influx. Since both fluxes fell in concert, there is no reason for believing that the fluxes are not coupled or that the source of ATP for the Na outflux is different from that for the K influx.


Studies on microperoxisomes. II. A cytochemical method for light and electron microscopy.


Fine structural localization of acyltransferase activity in rat hepatocytes.


Nucleoside phosphorylase activity in blood vessels and formed elements of the blood of the dog.


Quantitative assay of esterases in end plates of mouse diaphragm by electron microscope autoradiography.


Histochemical and chemical demonstration of reactive aldehyde groups in elastin.


Light and electron microscopic localization of antigens in tissues embedded in polyethylene glycol with a peroxidase labeled antibody method.


Occult melanoma.

Occult melanoma.


Anesthesia for fractured hips. Innovar versus halothane.


The Kansas State Board of Health. Legal basis and responsibilities.


Myocardial infarction and urolithiasis. A preliminary communication.


Electronic spread of current in monolayer cultures of neonatal rat heart cells.


The mechanism of action of DNP on phospholipid bilayer membranes.


Cation selectivity of the resting membrane of squid axon.


Venomous bites and stings in Mississippi.


The effects of maleic anhydride on the ionic permeability of red cells.


Radiologic seminar CXXII: orbital blow-out fractures.


Continuing medical education.

Continuing medical education.


Jackson area hospitals add more beds, offer specialized facilities.


Physics in the food laboratory.

Physics in the food laboratory.


Device for determining R f  values.

Device for determining R f  values.


The use of the Eskalab spectrophotometer alpha for non-Eskalab procedures.


A photochemical affinity-labelling reagent for the opiate receptor(s).


Vulnerability of desensitized or curare-treated acetylcholine receptors to irreversible blockade by cobra toxin.


Alterations in liver nuclear ribonucleic acid of rats treated with phenobarbital.


Further molecular orbital studies on the conformation of acetylcholine and its derivatives.


Evidence for post-transcriptional stabilization of ribosomal precursor ribonucleic acid by phenobarbital.


Interactions of a cobra neurotoxin and affinity labels of the acetylcholine receptor in the electroplax.


Lesions of the vertebral column in relation to spinal compression.


Two cases of Albers-Schonberg's disease with proptosis.


Spinal tumours associated with Klipel-Feil syndrome.


Intrathecal disc prolapse associated with lumbar canal stenosis.


The physician: dedicated, skillful, responsible and respected.


Anatomical study of circle of Willis.

Anatomical study of circle of Willis.


Women doctors past, present and future.

Women doctors past, present and future.


Stress urinary incontinence in the female. The role of bead-chain studies in diagnosis and treatment.


E.N.T. case of the month.

E.N.T. case of the month.


Breast cancer survival. The Ohio state university hospitals.


Ocular manifestations of sphenoid mucoceles. Case report and discussion.


The double sliding-door effect.

The double sliding-door effect.


Pupillary block and angle-closure glaucoma.


Prevention of retinal detachment by a circumferential barrage prior to lens extraction in high-myopic eyes.


Properties of cholinesterases of human ocular tissues.


Diffuse 'asbestosis-like' interstitial fibrosis of the lung.


Regressing melanoma metastasizing to an oligodendroglioma.


Agglutination test for the investigation of the genus Naegleria.


The role of platelets in the clearance of colloidal carbon from blood in rabbits: a light and electron microscope study.


Contribution of thrombus free and esterified cholesterol to atherosclerotic plaques.


Improving drug safety in hospitals through the unit dose concept.


Intestinal malakoplakia: report of a case.


Quantitative determination of barbiturates by means of gas-liquid chromatography and solid injection.


The hazards to the left circumflex coronary artery during mitral valve surgery in cases with atrial septal defects and corrected transposition.


Intra-operative measurement of the superior vena cava flow pattern in patients with intracardial shunts.


The influence of constrictive pericarditis on the superior vena caval flow pattern.


Low thrombotest values in active thrombosis.


The interelectrode electrical resistance at defibrillation.


Radiologic findings in pulmonary insufficiency following non-penetrating trauma of the chest.


The role of mediastinoscopy in the treatment of lung carcinoma.


Early repair of traumatic rupture of the thoracic aorta. Report of two cases.


Reflux oesophagitis its pathology and treatment.


Diagnostic tests for paroxysmal nocturnal hemoglobinuria.


Changes of iron metabolism in PNH: interrelationships of iron and DNA synthesis.


Haemodynamic factors in the oedema of arterial reconstructions.


Biochemistry of PNH cells: nature of the membrane defect.


Extended simple mastectomy; anatomic definition and uses.


Repair of frontal sinus defects with methyl-methacrylate.


Technic of radical perineal prostatectomy.


Postgastrectomy phytobezoar.

Postgastrectomy phytobezoar.


Retinopathy of juvenile diabetes: a comparative clinical study.


Air pollution and respiratory allergic disease.


Recurrent posttraumatic dislocation of the hip in children.


Pulmonary metastasis in testicular tumors: report of three cases of similar clinical interest.


Anorectoplasty prevents hemorrhoidectomy failures.


Reconstruction of traumatic losses of the external ear.


The physicians' role in human sexuality of the future.


Aggressive management of septic abortion: report of 262 cases.


Preanesthetic cardiac evaluation.

Preanesthetic cardiac evaluation.


The continuous paracervical block: its effect over the first stage of labor.


Synovial chondrometaplasia: a case report with spontaneous regression and a review of the literature.


Comments from the readers: thymic dysplasia associated with lymphopenia.


Comments from the readers: dosage of actinomycin.


Comments from the readers: errors in the Pap smears.


Comments from the readers: nuchal eczema.


Statistical study on malignant melanoma in Japan (1961-1970).


Residual catalase in the blood of Japanese acatalasemia.


Interaction between cortico-tectal and retino-tectal inputs as revealed by analysis of field potentials of the cat's superior colliculus.


A new type of fibergastroscope (FGS-BLG) for measurement of gastric lesions.


A case of carbamyl phosphate synthetase deficiency.


Observations on microcirculation in the mesentery of DCA hypertensive rats.


Effect of ivory shell toxin on the parasympathetic ganglia of the dog urinary bladder.


Effect of hyperpotassemia on AV conduction in dog heart in situ.


The sensitivity of the radioimmunoassay for detecting Australia antigen.


The presence of high and low incidence districts of Australia antigen in Miyagi prefecture.


Heart rate during bicycle ergometer exercise in Watts per kilogram body weight of 12 and 13 year old boys.


The diagnosis of measles in the newborn and infant age groups.


The relation of platelet adhesiveness to postoperative venous thrombosis of the legs. A clinical study.


Fibrinolytic activity of the blood and its relation to postoperative venous throbosis of the lower limbs. A clinical study.


Fractures of the head and neck of the radius treated by excision.


Double vertical fractures of the pelvis. A report on 163 patients.


Flow rates and manometry in the assessment of the common bile duct.


Small bowel propulsive motility in the rat. Studies with open and closed pylorus.


Propulsive motility and intraluminal pressure variations in isolated, homologously perfused small intestine.


Crohn's disease. A follow-up study.

Crohn's disease. A follow-up study.


Alterations in  45 Ca distribution and movements in ileal longitudinal smooth muscle.


Toxicological effects of vincristine sulfate on blood platelets.


Granulomatous prostatitis with emphasis on the eosinophilic variety.


Etiology of pigmented scars in the bronchial mucosa.


The plasma protamine paracoagulation test: clinical and laboratory evaluation.


A direct method for recording tension changes in the wall of small blood vessels in vitro.


Evaluation of a photoelectric automatic prothrombin analyzer.


Vascular thromboembolism complicating umbilical artery catheterization.


Pulmonary atresia with intact ventricular septum. New developments in diagnosis and treatment.


Pneumopericardium in the newborn.

Pneumopericardium in the newborn.


The cervical aortic arch.

The cervical aortic arch.


Severe congenital heart disease in the neonatal period. A functional approach to emergency diagnosis.


Rebound enlargement of the thymus after successful corrective surgery for transposition of the great vessels.


Skeletal changes associated with adolescent congenital heart disease.


Dermatoglyphics in congenital heart disease.


Pharmacological conditioning for sporting events. Theoretical considerations, hazards, and limitations.


Pulmonary lymphangiectasia. Observation in 17 patients and proposed classification.


Mediastinal lymphadenopathy in bubonic plague.


Bronchography in childhood asthma.

Bronchography in childhood asthma.


Posterior mediastinal "pseudo-mass" of the newborn.


Bile duct anomalies associated with duodenal atresia; paradoxical presence of small bowel gas.


Postoperative intussusception in children.


Choledochal cyst demonstrated by I 131  rose bengal scanning. Report of a case.


Clinical applications of cisternography in the pediatric age group.


Facial duplication.

Facial duplication.


Roentgenographic findings in familial osteodysplasia.


Product selection: community formularies and legal aspects. The pharmacist's responsibility in product selection.


Familial acrocephalosyndactyly (Pfeiffer syndrome).


A cardio-facial-skeletal syndrome.

A cardio-facial-skeletal syndrome.


Cockayne's syndrome. Roentgen findings.

Cockayne's syndrome. Roentgen findings.


Osseous changes of osteopathia striata and Pyle's disease occurring in a patient with an 11 year follow-up. A case report.


Synovial cysts in juvenile rheumatoid arthritis.


Ovarian cysts in the newborn.

Ovarian cysts in the newborn.


Ovarian teratoma in childhood. Diagnostic ultrasonic and roentgenographic correlation.


Pediatric radiologists--quo ibimus hinc?


Ultrasonic evaluation of masses in pediatric patients.


Microscopic anatomy of the skin of the horse.


Retention of unfertilized ova in uterine tubes of mares.


Development of the canine eye.

Development of the canine eye.


Use of A-mode echoencephalography in the dog.


Biochemical and ultrastructural observations in normal and degenerative canine articular cartilage.


Detection of artificially produced intracranial midline shifts of the brain in the dog with A-mode echoencephalography.


Relationship of glomerular number and diameter to body size of the dog.


Relationship between PP and PQ intervals in the electrocardiogram of dogs.


Structure of Ehrlichia canis in blood monocytes of a dog.


Canine cystinuria: its urinary amino acid pattern and genetic analysis.


Canine cystinuria: intestinal and renal amino acid transport.


Scanning electron microscopy of cervix uteri of cattle.


Experimentally induced infectious bovine keratoconjunctivitis: vaccination with nonviable Moraxella bovis culture.


Quantitative studies of urobilinogen excretion in normal Holstein-Friesian cattle.


Histologic and histochemical characterization of synovial membrane from normal and Mycoplasma hyorhinis-infected swine.


Infectivity of Oesophagostomum dentatum larvae in swine.


Electrophoretic distribution and serologic changes of blood serum of arthritic (rheumatoid) white-tailed deer (Odocoileus virginianus) infected with Erysipelothrix insidiosa.


Active immunization against duck hepatitis virus.


Relationship of feeding activity of face fly (Musca autumnalis DeGeer) to production of keratoconjunctivitis in calves.


Cryogenic preservation of Anaplasma marginale with Dimethyl sulfoxide.


Vascular anatomy of the uterus and ovaries and the unilateral luteolytic effect of the uterus: guinea pigs, rats, hamsters, and rabbits.


Detection of hydrogen peroxide in mycoplasma organisms frequently isolated from domesticated animals.


Identical increases in blood sialic acid of dogs given actinomycin D and dexamethasone.


Health and the urban environment. XI. The incidence and burden of minor illness in a healthy population: methods, symptoms, and incidence.


Health and the urban environment. XII. The incidence and burden of minor illness in a healthy population: duration, severity, and burden.


Health and the urban environment. 13. The incidence and burden of minor illness in a healthy population: familial spread.


Isoniazid-associated hepatitis. A study of five cases.


Small airway disease in asymptomatic asthmatic adolescents.


Patterns of distribution and clearance of aerosols in patients with bronchiectasis.


Subclavian arterial-pulmonary arterial fistula associated with healed cavitary tuberculosis.


Metabolic acidosis and lung mechanics in dogs to simulate a clinical condition.


Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data.


A practical method for monitoring bacterial contamination of inhalation therapy machines.


Oxygen tension measurements in small samples. Sampling errors.


Reagent-impregnated paper strip for detection of metabolic products of isoniazid in urine.


The maximal breathing capacity in extrathoracic airway obstruction.


Change of name for NTRDA.

Change of name for NTRDA.


Inhaled water droplets.

Inhaled water droplets.


Hydrodynamic behavior and molecular weight of homogeneous and of polydisperse native DNA.


Purification and properties of a polynucleotide ligase from calf thymus glands.


DNA synthesis in isolated nuclei from the brains of rats at different post-partal stages and the infant rat brain cytosol factor stimulating the DNA synthesis in infant rat brain nuclei.


On the absence of ribonuclease inhibitor in rat liver nuclei.


Free and membrane-bound polysomes of rat liver: separation in nearly quantitative yield and analysis of structure and function.


Effect of double-stranded RNAs from Sindbis virus-infected cells on rabbit reticulocyte and chick embryo cell-free protein synthesis.


Polymorphism in fowl serum albumin. 3. KC1 concentration effects on the yield and activity of chicken liver ribosomes.


The amino acid requirements of the growing chick. II. Growth and body composition of chicks fed on diets in which the proportions of amino acids are well balanced.


The effect of feeding a sub-optimum level of lysine to female chicks on the amino acid content of selected tissues and organs.


Effect of dietary protein restriction on the levels of free L-hydroxyproline in the plasma of the male domestic fowl.


A circadian rhythm of calcium intake in the domestic fowl.


The effect on chick growth of a trypsin inhibitor isolate from the field bean (Vicia faba L.).


Simultaneous stimulation of limbic system structures.


Amino acid incorporation in the brains of rats trained to use the non-preferred paw in retrieving food.


Effects of reserpine and monoamine oxidase inhibition on the levels of amino acids in sensory ganglia, sympathetic ganglia and spinal cord.


Antagonism by taurine of cobalt induced epilepsy in cat and mouse.


Nucleic acid metabolism of the neuroglial cells of the rat neural lobe.


Fractionation of RNA of the rat neural lobe labeled in vitro: comparison with RNA of cerebral cortex labeled in vivo.


Epileptiform activity and neural plasticity in limbic structures.


Studies on RNA methylation and dissociation between RNA and protein biosynthesis in neural lobes of dehydrated rats.


Responses of neurones in the rabbit inferior colliculus. I. Frequency-specificity and topographic arrangement.


Adaptation of the olfactory bulbar response in fish.


Responses of neurones in the rabbit inferior colliculus. II. Influence of binaural tonal stimulation.


DNA binding and inhibition of DNA synthesis after 7,12-dimethylbenz(a)anthracene administered during the early prereplicative phase in regenerating rat liver.


Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism.


Removal of bound carcinogen during DNA repair in nondividing human lymphocytes.


Carbamyl phosphate hydrolysis in rat tissues and tumors by an alkaline phosphatase.


The effect of route af administration on the distribution of ellipticine in mice.


Antineoplastic effect of chlorpromazine in chemical carcinogenesis in the hamster cheek pouch.


A simple formula for calculation of the total dose in fractionated radiotherapy.


Total-body hyperthermia versus primary tumor hyperthermia in the treatment of the rabbit VX-2 carcinoma.


Metabolite activation and glycine accumulation in Ehrlich ascites tumor.


Natural toxins in food and feeds.

Natural toxins in food and feeds.


Implications of mycotoxins.

Implications of mycotoxins.


Letters: Paraquat poisoning--prolonged excrretion.


Sequential development of the lesions in locoweed poisoning.


Metabolic sensitivity of Fasciola hepatica to mammalian hormones in vitro.


Alpha absorption measurements applied to lung dose from radon daughters.


Measurement of radon daughters in air.

Measurement of radon daughters in air.


Measurements of uncombined radon daughters in uranium mines.


Further studies on the long-term evaluation of the biological half-life of tritium.


The relation between  -dose in the skin and  -exposure from surfaces contaminated with aged fission products.


Genetically significant dose from diagnostic medical x-ray examinations in Japan, 1969.


Population mean marrow dose and leukaemia significant dose from diagnostic medical x-ray examinations in Japan, 1969.


A convenient method for removal of radioactive contamination in particulate form.


Emergent dose estimation of non-occupational persons accidentally exposed to  192 Ir gamma rays.


Thickness of bronchial epithelium with relation to exposure to radon.


Eye exposure by thorium contained lenses.


Disposal of radioactivity into a city sewerage system.


Dose equivalent index.

Dose equivalent index.


Retention of simulated fallout particles by lichens and mosses.


A correction in the comparison of  210 Pb skeletal levels with radon daughter exposures.


On the applicability of the method based on the transport theory to the determination of dose distribution of  -radiation in a tissue-equivalent material.


In regard to "boundary condition" for point source functions of beta radiation.


Comparable coupler and real-ear measurements on supraaural- and insert-type earphones.


Postmasking recovery of human click action potentials and click loudness.


Cooperation of listener and computer in a recognition task. II. Effects of computer reliability and "dependent" versus "independent" conditions.


Network representation of the external ear.


New boundary conditions and results for the Peterson-Bogert model of the cochlea.


Discrimination of interaural time and intensity.


Modeling and simulation of the cochlear potentials of the guinea pig.


The critical masking interval.

The critical masking interval.


Response patterns of single cochlear nerve fibers to click stimuli: descriptions for cat.


Latency of whole-nerve action potentials: influence of hair-cell normalcy.


Perceptual structure of 22 prevocalic English consonants.


Shear as a mechanism for sonically induced biological effects.


The effects of dc current polarization on cochlear harmonics.


Cochlear potential response at the round-window membrane of the cat--a reply to the comment of G. R. Price.


A functioning HMO.

A functioning HMO.


The relationship of the HMO to the college and university health service in the rural setting.


In the urban setting.

In the urban setting.


HMO's and private health insurance.

HMO's and private health insurance.


The HMO and college health services.

The HMO and college health services.


The Williams-Steiger Occupational Safety and Health Act of 1970.


The responsibilities of institutions of higher education under the Occupational Safety and Health Act of 1970.


Accreditation in higher education.

Accreditation in higher education.


Some observations on coping styles of black students on white campuses.


Vaccine requirements of college students.


Complaints patients bring to a student mental health clinic.


Health services--consumer awareness leads to utilization.


Ambisexuality as an alternative adaptation.


Sex on the campus and the college health service.


A descriptive study of a pregnancy counseling service in a university health service.


Troubleshooting and problem solving with the development and operation of a family planning clinic.


The nurse practitioner clinic in a university health service.


The Oberlin College health plan.

The Oberlin College health plan.


The nurse practitioner clinic at the University of Massachusetts health service.


Traumatic rupture of the testicle in tackle football: a case report.


Ectopic pregnancy and the intrauterine device.


Seasonal incidence of infectious mononucleosis.


Exposure of caged Biomphalaria glabrata (Say) to investigate dispersion of miracidia of Schistosoma mansoni Sambon in outdoor habitats in St. Lucia.


Effects of some physico-chemical factors on the infection of Biomphalaria glabrata (Say) by miracidia of Schistosoma mansoni Sambon in St. Lucia, West Indies.


Effect of water depth on the infection of Biomphalaria glabrata by miracidia of St. Lucian Schistosoma mansoni under laboratory and field conditions.


Occurrence of Eubothrium crassum (Bloch, 1779) (Cestoda: Pseudophyllidea in brown trout Salmotrutta L., and rainbow trout S. gairdneri Richardson, 1836, from Hanningfield Reservoir, Essex.


Afromacroderoides lazerae gen. et sp. nov. (Allocreadiidae: Walliniinae), a new digenean from the African freshwater fish Clarias lazera.


Helminths from wild anatids in Great Britain.


Migration and growth of Ancylostoma ceylanicum in golden hamsters Mesocricetus auratus.


Some digenetic trematodes of birds from Palawan Island, Philippines.


Redescription of Bovienia serialis (Bovien, 1926) (Cestoidea: Caryophyllidea) from the catfish Clarias batrachus (L.) in India.


A preliminary note on the susceptibility, prepatency and recovery of Fasciola gigantica in small laboratory animals.


Changes in the distribution and chemical composition of Hymenolepis diminuta, and the intestinal nutritional gradients of uninfected and parasitized rats following a glucose meal.


Age-related ultrastructural changes in the flight muscle of the mosquito, Culex tarsalis.


Ultrastructural changes in Culex tarsalis flight muscle associated with exhaustive flight.


Maternal induction of larval diapause in the blowfly, Calliphora vicina.


Compartmental and semicompartmental approaches for measuring glucose carbon flux to fatty acids and other products in vivo. We have attempted to estimate the flux of glucose carbon to total body fatty acids and to other metabolic end products in Bar Harbor 129/J mice fasted 5-8 hr. Tracer [U-(14)C]glucose was injected intravenously, and the following data were obtained at various times up to 180 min: plasma glucose C specific activity, plasma glucose concentration, total body glycogen, and (14)C in total body fatty acid, total body lipid, unsaponifiable lipid, expired CO(2), and in hepatic and extrahepatic glycogen. The data were analyzed by three techniques, namely, multicompartmental, semicompartmental, and noncompartmental analyses. All three methods yielded comparable rates of glucose C conversion to total body fatty acids (2-3 micro g of glucose C/min/20 g of body weight). Although the semicompartmental approach is extremely simple (it only requires analyses of plasma glucose specific activity as a function of time and (14)C-labeled fatty acid at one point in time), it gives an apparently valid approximation for the flux of glucose C to fatty acids. Other quantitative aspects of glucose metabolism in postabsorptive mice are also considered.


Movement of cholesterol in vitro in rat blood and quantitation of the exchange of free cholesterol between plasma and erythrocytes. After administration of [4-(14)C]cholesterol to rats, blood was obtained and incubated for 6 hr or less. Incubation resulted in a net loss of erythrocyte cholesterol and, simultaneously, in an increase of esterified cholesterol in plasma and alpha-lipoproteins. Erythrocyte labile cholesterol was shown to be the sole precursor of esterified cholesterol. However, the relation between loss and esterification was not absolute. Loss of erythrocyte cholesterol could be inhibited without affecting esterification and vice versa. A catenary turnover model is proposed, which links in vivo erythrocyte labile cholesterol and plasma esterified cholesterol. Free cholesterol also exchanged between erythrocytes and lipoproteins. The topological model, as tested by analog computer, appears to be a bicompartmental system governed by nonconstant exchange fluxes. They are exponential functions of time and vary from 0.065 to 0.020 mg/hr/g of blood. The fitting of the curves obtained by analog computer analysis to the experimental curves requires esterification as described above. Variation of the exchange fluxes would be the consequence of lipoprotein structural alterations. If this is true, the initial value of the measured flux in vitro is identical with the in vivo value, and the turnover time of erythrocyte cholesterol is 9.2 hr. Initial exchange flux is not dependent on plasma cholesterol level or on the age of the rats, but it is temperature dependent. Addition of amphotericin B to the plasma does not modify exchange fluxes, but erythrocyte cholesterol loss is increased.


Artifacts in ultracentrifugal estimation of aqueous fatty acid concentration. Ultracentrifugation for determination of isotropic concentrations of fatty acids is widely used. However, several artifacts, which would affect the isotropic concentration, could occur if care is not taken. These include sedimentation of micelles, incomplete flotation of unsolubilized oil, and uptake of labeled fatty acid by the walls of centrifuge tubes. The first artifact can be overcome by sampling large volumes from the ultracentrifuged sample, and the second by ultracentrifugation for long periods; a force-duration of 7.2 X 10(7) g-min is suitable. The third artifact cannot be eliminated but may be made constant if the duration of exposure of lipid mixtures to centrifuge tubes is kept constant.


Uptake and metabolism of circulating chylomicron triglyceride by rabbit aorta. To determine if chylomicron triglycerides are taken up and metabolized by the arterial wall, rabbit abdominal aortas were perfused in situ for various times up to 2 hr with blood-buffer containing isotopically labeled substrates. Labeled chylomicrons were obtained by feeding [(3)H]palmitic acid or [(3)H]glyceryl trioleate to rats and rabbits with cannulated thoracic ducts. After aortic perfusion with these chylomicrons, more than 85% of aortic lipid ester radioactivity was in triglyceride; when labeled glycerol or palmitic acid was perfused, most aortic ester lipid radioactivity was in diglycerides and phospholipids. This indicated that, during perfusion with chylomicrons, intact triglyceride molecules were taken up by aorta. The rate of triglyceride fatty acid uptake by the inner avascular segment approached maximal values at low concentrations of perfusate triglyceride fatty acids (2 mm), whereas uptake in the outer capillary perfused segment increased with increasing triglyceride fatty acid concentration (0.4-25 mm). By double-radioisotope techniques it was shown that aortic free fatty acid was derived from both perfusate free fatty acids and from hydrolysis of lipoprotein glycerides within the aortic wall. Uptake of chylomicron triglyceride by perfused aorta was independent of triglyceride hydrolysis, which was quantitatively small.


Hydrolysis of glyceryl tri(1- 14 C)octanoate and glyceryl tri(1- 14 C)oleate monolayers by postheparin lipolytic activity. The hydrolysis of monomolecular films of glyceryl tri[1-(14)C]octanoate and glyceryl tri[1-(14)C]oleate has been demonstrated by measurement of the decrease in surface radio-activity that occurs in the presence of postheparin plasma. The hydrolysis displayed first order kinetics and was proportional to enzyme concentration over a 10-fold range. No hydrolysis was observed in the absence of enzyme, and only slight activity (1%) was found in plasma taken from subjects before heparin administration. The hydrolysis was stimulated to a variable extent by Ca(2+). The first product of hydrolysis of the monolayer was identified as 1,2-diglyceride, which was subsequently converted to 2-monoglyceride. Inhibition of triglyceride hydrolysis was observed when postheparin plasma was preincubated in 2 m NaCl, 10(-4) m protamine, 10 mm Na(4)P(2)O(7), and 0.1 m NaF. Monolayer techniques avoid some but not all of the problems associated with emulsified lipid substrates and appear to be applicable for study of post-heparin lipolytic activities.


Digestion in vitro of erythritol esters by rat pancreatic juice enzymes. The mechanism of the digestion of erythritol esters was determined using rat pancreatic juice and purified pancreatic lipase (EC 3.1.1.3). Conditions of hydrolysis were used that would selectively activate or inactivate nonspecific lipase or lipase. It was shown that erythritol tetraoleate was hydrolyzed by nonspecific lipase but not by lipase. The initial digestion product was a triester, predominantly erythritol-1,2,3-trioleate. Thus, nonspecific lipase preferentially hydrolyzed the ester of a primary alcohol. In contrast to the results obtained with the tetraester, lipase could remove a fatty acid from the triester but the resulting erythritol-2,3-dioleate was not hydrolyzed by lipase. The selectivity of this hydrolysis and the inability to hydrolyze the diester are attributed to the known specificity of this enzyme to act only on esters of primary alcohols. Nonspecific lipase completely hydrolyzed erythritol tetraoleate to free erythritol in a stepwise manner. The relative rates of these reactions were tetraester --> triester --> diester --> monoester --> erythritol Because of the specificity of pancreatic lipase and the lack of specificity of nonspecific lipase it is likely that this latter enzyme is the primary agent for the hydrolysis of erythritol esters in the intact animal.


Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase. The diurnal cycle of hepatic HMG CoA reductase activity was studied under conditions of controlled feeding where the percentage of dietary lipid, alone or in combination with 2% cholestyramine, was varied. Cholestyramine caused an increase in HMG CoA reductase activity that began soon after feeding started and peaked 6 hr later. In contrast, a diet containing 20% corn oil was a much weaker inducer of the enzyme but caused a prolonged elevation that began late in the fasting part of the cycle. These patterns suggest two different mechanisms of action.


Calculation of lipolysis and esterification from glycerol metabolism in rat adipose tissue. Pieces of epididymal fat pad from fed and 48-hr-fasted rats were incubated for various periods of time in Krebs-Ringer bicarbonate containing [1-(14)C]glycerol. The radioactive substrate taken up by the tissue increased linearly with time in both groups and was mainly converted to glyceride-glycerol and CO(2). The slopes of the regressions of (14)C-labeled glyceride-glycerol with time were not different between the groups, while those of (14)CO(2) were smaller in the fasted than in the fed animals. Because the radioactive glycerol in the medium is being continuously diluted with the glycerol coming out of the tissue, it is necessary to take account of this factor in calculating the actual amount of glycerol utilized by the tissue. The glycerol produced by the tissues is higher in the fasted than in the fed animals, and in both groups it increases hyperbolically with time. As negligible amounts of the (14)C-labeled glycerol taken up by the tissue recirculates to the medium, the rates of glycerol release (lipolysis), esterification, and oxidation to CO(2) were calculated.


Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions. The oxidative desaturation of [1-(14)C]eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid by rat liver microsomes was studied, and the kinetic conditions appropriate to measure the specific activity of the enzyme were determined. A comparative study of the effects of a balanced diet and essential fatty acid-free diets on the oxidative desaturation of oleic and linoleic acids at the 6,7 position and the oxidative desaturation of eicosadienoic acid at the 5,6 position were made. Eicosadienoic acid showed a higher conversion than oleic acid for all the diets. The conversion of oleic and linoleic acids to Delta6 acids was equally increased by fat-free diets with or without added methyl palmitate, whereas the oxidative 5-desaturation of eicosadienoic acid at the 5,6 position was not changed. The effect was apparently independent of the amount of endogenous free fatty acids. The results suggest that the rate-limiting and principal regulatory step in the biosynthesis of eicosa-5,8,11-trienoic acid is the 6-desaturation of oleic acid. The 5-desaturation of eicosadienoic acid was increased by a protein diet and decreased by alloxan diabetes to a lesser extent than the 6-desaturation of linoleic acid. The 5-desaturation of eicosadienoic acid would constitute a secondary regulatory step.


Hematologic problems in pregnancy. I. The data base.


Synthesis of ceramides using N-hydroxysuccinimide esters. Fatty acyl esters of N-hydroxysuccinimide have been used to directly N-acylate sphingenine or sphinganine, forming the corresponding ceramides. The reaction proceeds in excellent yield (84-96%) from small amounts of starting material (10-20 mg). The product ceramides are pure after one recrystallization.


A simple lipase assay using trichloroacetic acid. An extremely rapid and sensitive assay for lipoprotein lipase activity, suitable for routine determinations, is described. The substrate for the assay is emulsified [2-(3)H]glyceryl trioleate, activated by serum. The method is based on trichloroacetic acid precipitation of unreacted substrate and measurement of (3)H-labeled glycerol.


"Normal" host response to Au(1)-associated hepatitis virus outbreak in a chronic dialysis unit in Israel.


Advice to psychiatric patients.

Advice to psychiatric patients.


The distress of dying.

The distress of dying.


Goodwin F:An exercise in teamwork.

Goodwin F:An exercise in teamwork.


Emigrating to the USA?

Emigrating to the USA?


Part of the community: John Conolly Hospital.


The Darlington Experiment: by, with and for the community.


Black is black and white is white.

Black is black and white is white.


Taxonomy of trypanosomes (Protozoa: Trypanosomatidae) of Spermophilus spp. (Rodentia: Sciuridae).


Prevalence of Trypanosoma otospermophili (Protozoa: Trypanosomatidae) in five species of Spermophilus (Rodentia: Sciuridae).


Gland cells in the redia of Fasciola hepatica.


Immunity to coccidiosis: effect of serum antibodies on cell invasion by sporozoites of Eimeria in vitro.


Larvae of the British Metastriata (Ixodoidea: Ixodidae).


Invasion of skin by larvae of the cat hookworm, Ancylostoma tubaeforme.


Toxocara vajrasthirae sp.nov. from the hog-badger (Arctonyx collaris) of Thailand.


Nippostrongylus brasiliensis: observations on the comparative immunogenicity of adult worms from primary and immune-adapted infections.


Ecological studies of larval ticks in South Africa (Acarina: Ixodidae).


Functional outcome at a distance of time (more than 3 years) in pulmonary resections (lobectomies) in relation to the original illness.


Preoperative function analysis--possibilities and limits.


Reinfections in rubella.

Reinfections in rubella.


Trimethoprim-sulphamethoxazole in enteric infections.


Facial skeleton growth after periosteal resection. An osteometric, roentgenographic and histologic study in the rabbit and guinea pig.


Diurnal rhythm of neurosecretory activity in normal and x-ray irradiated mice.


Ultrastructural alterations in the cerebral ganglion of Anodonta cygnea L. (mollusca, pelecypoda) induced by transection of the cerebro-visceral connective.


Electronmicroscopic observations on the antigen receptors in the tonsillar tissue.


Phylogenesis of mast cells. 3. Effect of hormonal induction on the maturation of mast cells in the frog.


In vitro model of feed-back mechanism between different endocrine gland and rat pineal in tissue culture.


Tubular hydrodynamics after administration of ethacrynic acid.


Articular reflexes at the knee joint: an electromyographic study.


Effects of insulin on lipoprotein lipase activity in the rat heart and adipose tissue.


Catecholamine excretion after hypophysectomy and with hydrocortisone administration.


Selective uptake of immunoglobulins by the proximal intestine of suckling rats.


Diabetes and intestinal calcium absorption in the rat.


Effect of magnesium on water permeability of the rat nephron.


Intestinal uptake of iron, cobalt, and manganese in the iron-deficient rat.


Colon slow waves: size of oscillators and rates of spread.


Inhibition of plasminogen activators by naturally occurring inhibitors in man.


Metabolism of erythropoietin by isolated perfused livers of dogs treated with SKF 525-A.


Evidence for an insulin-sensitive receptor in the central nervous system.


Comparative study of Pa CO2  in several homeothermic species.


Dynamics of water-isotope distribution.

Dynamics of water-isotope distribution.


Oxidation of leucine by rat skeletal muscle.


Oxidation of amino acids by diaphragms from fed and fasted rats.


Effects of hypoxemia and acute coronary occlusion on myocardial metabolism in dogs.


Clinical and chemical correlations in magnesium-deprivation encephalopathy of young rats.


Sequential changes in hepatic blood flows during hemorrhagic shock.


Conditioned hypoglycemia: effect of vagotomy and pharmacological blockade.


Energy balance and lactic acid production in the exercising rabbit.


Effect of a pharmacologic dose of digoxin on inotropy in hyper- and normokalemic dogs.


Renal tubular transport of calcium and phosphate in snakes: role of parathyroid hormone.


Hemodynamic effects of bradycardia in the fetal lamb.


Sympathetic innervation of urinary bladder of the guinea pig.


Tolerance of isolated heart muscle to hypoxia: turtle vs. rat.


Myocardial oxygen consumption during isotonic and isolumic contractions in the intact heart.


Effect of traumatic shock on plasma catecholamine levels in man.


Modification of digitalis-induced electrocardiographic changes by propranolol and potassium.


Pulmonary function in exudative pleurisy.


Lactate, malate and glutamate dehydrogenase activity in mediastinal lymph nodes in sarcoidosis.


Effect of environmental temperature on hospital admissions for cerebrovascular accidents.


Dermal-epidermal separation. II. External factors in suction blister formation with special reference to the effect of temperature.


Heart failure as a complication of hemodialysis arteriovenous fistula.


Cobalt test for the detection of iron deficiency anemia.


Infrequently encountered Pseudomonas species causing infection in humans.


Fibrous dysplasia of bone and primary hyperparathyroidism.


Criteria for the diagnosis of alcoholism.


Chronic hemodialysis in myelomatosis.

Chronic hemodialysis in myelomatosis.


Ventricular fluid and the management of coccidioidal meningitis.


The epidemiology of Hodgkin's disease.

The epidemiology of Hodgkin's disease.


Physicians are part of the problem.

Physicians are part of the problem.


Getting the public's ear on arteriosclerosis.


Engel unopposed?

Engel unopposed?


Acetylsalicylic acid and HL-A antigens.

Acetylsalicylic acid and HL-A antigens.


Residencies down the drain?

Residencies down the drain?


Acute anemia with factor VIII therapy.

Acute anemia with factor VIII therapy.


Side-to-side for "steal"?

Side-to-side for "steal"?


Pancreatitis and phenformin.

Pancreatitis and phenformin.


Defibrination or primary fibrinolysis?

Defibrination or primary fibrinolysis?


Magic wand for aortic insufficiency?

Magic wand for aortic insufficiency?


What is "normal" serum calcium?

What is "normal" serum calcium?


Progesterone, pulmonary hyperventilation, and cirrhosis.


The cellular stromal reaction in malignant melanoma. A cytochemical investigation.


Hydrocortisone butyrate penetration through epidermis in vitro. Influence of vehiculum, connectration in the vehiculum, and the amount applied.


Cerebral gamma-camera gammagraphy with  99m Tc pertechnetate ion.


Calcium effects on erythrocyte membrane proteins.


Identification of 16-oxo-9-hydroxy hexadecanoic acid, a novel monomer, as a major component of the biopolymer cutin in embryonic Vicia faba.


Subribosomal particulate forms of elongation factors and aminoacyl-tRNA synthetases in human cells.


Two classes of membrane-bound ribosomes in rat liver cells and their albumin synthesizing activity.


Studies on DNA synthesis in murine myeloma. II. Activation of latent RNA-dependent DNA polymerase activity in membrane fractions.


Half-of-the-sites reactivity of yeast glyceraldehyde 3-phosphate dehydrognease.


Characterization of T7 specific RNA polymerase. 3. Inhibition by derivatives of rifamycin SV.


Heterogeneity of insulin receptors on fat cell membranes.


Isolation and characterization of an active DNA-binding metabolite of benzo(a)pyrene from hamster liver microsomal incubation systems.


Dissociation-association properties of apoferritin in the milligram and microgram range.


Assignment of the C-2 histidine proton magnetic resonances of ribonuclease-A.


The effect of Mg ++  on the conformation of the Ca ++ -binding component of troponin.


The binding of calcium by chymotrypsinogen A.


Biosynthesis of acidic glycolipids in cotton fibers. Possible intermediates in cell wall synthesis.


Entropic rate accelerations and orbital steering.


The differential effect of Ca-ATP and Mg-ATP on platelet actomyosin.


Red cell membrane glycoprotein: amino acid sequence of an intramembranous region.


Suppression of acute secondary disease by heterologous anti-brain serum.


Preparation of the mineral phase of bone using ethylenediamine extraction.


Geometric properties of the second metacarpal.


The electrochemical behaviour of human dental enamel after topical fluoride treatment.


Preliminary clinical experience with cis-diamminedichloroplatinum (II) (NSC 119875, CACP).


Therapy of malignant melanoma with an imidazole carboxamide and bis-chloroethyl nitrosourea.


Treatment of the patient with adenocarcinoma of unknown origin.


Chemotherapy of gestational choriocarcinoma.


Combination chemotherapy and radiotherapy for Hodgkin's disease.


Chemotherapy of Burkitt's lymphoma.

Chemotherapy of Burkitt's lymphoma.


Treatment of clinically localized Ewing's sarcoma with radiotherapy and combination chemotherapy.


Hormonal therapy of breast cancer.

Hormonal therapy of breast cancer.


Surgical adjuvant therapy for breast cancer.


Treatment of neuroblastoma.

Treatment of neuroblastoma.


Prospectus for cancer chemotherapy.

Prospectus for cancer chemotherapy.


Role of vagal afferents in the control of renal sympathetic nerve activity in the rabbit.


Partition of the carotid sinus baroreceptor response in dogs between the mechanical properties of the wall and the receptor elements.


Effects of mineralocorticoids, altered sodium intake, and adrenalectomy on urinary kallikrein in rats.


A feedback mechanism responsible for fixed coupling in parasystole.


Role of the Frank-Starling mechanism in exercise.


Regulation of the renal circulation during severe exercise in normal dogs and dogs with experimental heart failure.


Effects of training and detraining on the distribution of cholesterol, triglyceride, and nitrogen in tissues of albino rats.


Multibolus technique for measuring the distribution of cerebral blood flow over short intervals in man.


Diabetes in the sand-rat: diabetogenesis, responses to mannoheptulose and atriplex ash.


Use of potassium canrenoate to suppress ouabain-induced ventricular arrhythmias in dogs.


Feedback regulation of cholesterol biosynthesis: studies with cholestyramine.


Day-to-day variation of continuously monitored glycaemia: a further measure of diabetic instability.


Microcirculatory disturbances of occlusive diseases of the eye.


Studies on the pathogenesis of lipoatrophic diabetes: a case of congenital systemic absence of adipose tissue associated with insulin-resistant diabetes mellitus and hepatosplenomegaly.


Electronystagmography (ENG) in vestibular testing.


The audiological diagnosis of deafness.

The audiological diagnosis of deafness.


Two variations of bone conduction testing. 2. The Bing test.


Ultrasonics and ophthalmology.

Ultrasonics and ophthalmology.


An ophthalmic scan of Malawi, Africa.

An ophthalmic scan of Malawi, Africa.


The effect of noise on vision.

The effect of noise on vision.


Adjuncts to tear duct probing.

Adjuncts to tear duct probing.


Design lines: university medical program requires unique facilities.


Public relations: low key defuses confrontation.


Lenox Hill's outreach program.

Lenox Hill's outreach program.


Blood banking: controls constrict sources.


Handbooks simplify, improve committee work.


Does staff representation equal active participation?


Laundry: immigration raids: new occupational hazard.


TPRs: an old habit or a significant routine?


Plant operation: setting up a PM system. 2.


Drug profile follows patient into community.


Lipoproteins in LCAT-deficiency.

Lipoproteins in LCAT-deficiency.


Contribution to the genetics of serum beta-lipoprotein in man. VI. Evidence for the existence of the Ag t-z locus, closely linked to the Ag x-y , Ag a1-d  and Ag c-g  loci.


Chromosome studies in patients with ulcerative colitis.


Homozygous duplication on long arm of chromosome pair no. 1.


Red blood cell NADH diaphorase in Italian populations.


Gene frequencies of soluble glutamic-pyruvic-transaminase in a northern German population (Hamburg).


Localization of the deleted segment in the Cri-du-Chat syndrome.


A case of the 18p--syndrome.

A case of the 18p--syndrome.


Study of physiological availability of temazepam in man.


The change in serum, urine and renal tissue levels after administration of various doses of carbenicillin.


Sensitivity of staphylococcus aureus to minocycline, doxycycline and tetracycline.


The effect of D- and DL-propranolol on blood pressure and cerebral norepinephrine in rats with DOCA-hypertension.


Studies on the activity of a new antimycotic (Bay b 5097) in children.


Specific adherence of in vitro differentiated lymphocytes to target cells. Blast cells which were derived from rat lymphocytes by stimulation with phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM) transformed within 2-3 days into a new type of lymphocytes when plated without mitogen on embryo fibroblast monolayers. These lymphocytes were termed secondary lyrophocytes. Upon addition of PWM to PWM-secondary lymphocytes a marked adherence to fibroblast monolayers was observed. The degree of adherence was estimated (a) by direct count of the lymphocytes in the medium and in the trypsinized fibroblast fraction, and (b) by using (51)Cr-labeled lymphocytes. The adherence process required incubation at 37 degrees C. The process started immediately after the addition of PWM and reached a plateau at 6 hr. At this time more than 80% of the lymphocytes adhered. In the absence of PWM only 12% of the lymphocytes were found in the fibroblast fraction. Unlike PWM-lymphocytes. Con A-lymphocytes, PHA-lymphocytes, and ordinary lymphocytes taken directly from the rat lymph nodes adhered only slightly more in the presence of PWM (10-20% adherence of ordinary lymphocytes) than in its absence (8% adherence). The adherence of the secondary lymphocytes and the ordinary lymphocytes was also studied in the presence of Con A and PHA. These mitogens induced high rate of adherence and they did not demonstrate specificity in their action. The adherence was accompanied by transformation of the lymphocytes to blast cells endowed with target-cell lytic ability. This transformation occurred mostly in the adhering fraction of the lymphocyte population. The results support the notion that target-cell recognition and destruction in cellular immunity involve contact between the cells.


Lysosomes in rat thoracic duct lymphocytes. 10 acid hydrolases known to be lysosomal in other tissues were detected in rat thoracic duct lymphocytes (TDL). Except for cathepsin D, all these enzymes occurred in lower levels in TDL than in rat spleen. Fractionation by means of differential centrifugation revealed two types of distribution patterns. Most of the total cathepsin D activity appeared in a high-speed supernatant (S), whereas the other acid hydrolases associated mainly with a high-speed pellet (P). Further studies by isopycnic centrifugation in a sucrose density gradient showed that all the enzymes, including a small portion of cathepsin D, sedimented around a modal density of 1.18. In contrast, most cathepsin D activity was recovered in a soluble, unsedimentable form. These results suggest the presence of two populations of lysosomes. Because the possibility could be excluded that other cell types contaminated the lymphocyte preparations, it is concluded that both lysosomal populations arise from TDL.