Recurrent hyperthyroidism presenting as triiodothyronine toxicosis.


Nuclear magnetic resonance studies of carbonic anhydrase. Binding of sulfacetamide to the manganese enzyme.


Rate of depurination of native deoxyribonucleic acid.


Hemoglobin messenger ribonucleic acid translation in cell-free systems from rat and mouse liver and Landschutz ascites cells.


Similarities in chromosomal puffing induced by temperature shocks and dinitrophenol in Drosophila.


Photooxidative death in blue-green algae. When incubated in the light under 100% oxygen, wild-type blue-green algae (Anacystis nidulans, Synechococcus cedrorum) die out rapidly at temperatures of 4 to 15 C, and at 35 C (or at 26 C in the case of S. cedrorum) in the absence of CO(2). Photosynthesis is impaired in these cells long before they die. Blocking of photosystem II at high temperatures in the presence of CO(2) sensitizes the algae to photooxidative death. Photooxidative death and bleaching of photosynthetic pigments are separable phenomena. Photooxidative conditions were demonstrated in Israeli fish ponds using A. nidulans as the test organism during dense summer blooms, when dissolved CO(2) is low, and in winter, when water temperatures generally drop below 15 C. This finding suggests that photooxidative death may be responsible for the sudden decomposition of blue-green blooms in summer, and may be a factor in the absence of blue-green blooms in winter.


In-vitro activity of an antibacterial substance from rabbit polymorphonuclear leukocytes.


Intergenotic transformation of the Bacillus subtilis genospecies. A multiple auxotrophic derivative of Bacillus subtilis 168 (strain BR151 carrying lys-3, trpC2, metB10) was transformed with deoxyribonucleic acid (DNA) isolated from B. subtilis 168, Bacillus amyloliquefaciens H, B. subtilis HSR, Bacillus pumilus, and Bacillus licheniformis. Transformation with heterologous DNA occurred at a very low frequency for the three auxotrophic markers. Heterologous transformation to rifampin resistance was 100 to 1,000 times more efficient than transformation to prototrophy. Transformants from the various heterologous exchanges were used to prepare donor DNA. The fragment of integrated DNA from the heterologous (foreign) species, termed the "intergenote," was capable of transforming BR151 with an efficiency almost equal to that of homologous DNA. When BR151 DNA contained the Rfm(R) (rifampin resistance) intergenote from B. amyloliquefaciens H, the frequency of transformation was frequently greater than that of the homologous DNA. Accompanying this increased efficiency was a marked change in the physiology of the cells. The growth rate of the transformants carrying this intergenote was approximately one-half that of either parental strain. Thus, in a prokaryotic transformation system, adverse side effects can occur after incorporation of a segment of foreign DNA.


Experimental measles encephalitis in normal and cyclophosphamide-treated rhesus monkeys.


Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man.


Phage typing in diphtheria outbreaks in the southwestern United States, 1968-1971.


Hepatitis-associated antigen and specific antibodies in sera of convalescents and patients with viral hepatitis.


Developmental genetics of hexokinase isozymes in Drosophila melanogaster.


Encephalitozoonosis: evidence for vertical transmission.


Spontaneous pattern preferences of Drosophila melanogaster to black areas in various parts of the visual field.


The fine structure of the eye of a visual mutant, A-type of Drosophila melanogaster.


Actions of histamine on human, sheep and monkey umbilical vasculature.


Diamine oxidase: specificity and mechanism.


Effect of vitamin E on the development of stress-produced gastric ulceration in the rat.


Qualitative alterations in enzymatic properties of amine oxidases.


Comparing nutritional status methods in a Guatemalan survey.


Essential fatty acid deficiency in infants induced by fat-free intravenous feeding.


An approach to nutrition planning.

An approach to nutrition planning.


Interaction between placental alkaline phosphatase and ABO system polymorphisms during intrauterine life.


On the biosynthesis, intracellular transport and mechanism of conversion of proinsulin to insulin and C-peptide.


Insulin--clinical aspects: the first fifty years.


Subacute spongiform virus encephalopathies. Scrapie, Kuru and Creutzfeldt-Jakob disease: a review.


the influence of the cerebellum in cat penicillin epilepsy.


Tonic status epilepticus precipitated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome.


The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.


Spontaneous seizure frequency and avoidance conditioning in monkeys.


Tonic status epilepticus precipitated by intravenous diazepam in a child with petit mal status.


An electrophoretic analysis of Drosophila histones. I. Isolation and identification.


Enucleation of mammalian cells by cytochalasin B. I. Characterization of anucleate cells.


An electrophoretic analysis of Drosophila histones. II. Comparison of larval and adult histone patterns in two species of Drosophila.


A quantitative assay for measuring cell agglutination: agglutination of sea urchin embryo and mouse teratoma cells by concanavalin A.


Bridging of peptides to solid supports through the dinitrophenylene moiety. Bidirectional extension of peptide chains.


Multiple congenital dislocations associated with other skeletal anomalies (Larsen's syndrome) in three siblings.


Direct immunoassay of triiodothyronine in human serum. A sensitive and precise radioimmunoassay for the direct measurement of triiodothyronine (T(3)) in human serum has been designed using sodium salicylate to block T(3)-TBG binding. This assay is sufficiently sensitive to quantitate T(3) accurately in 50-100 mul of normal serum and to measure quantities as small as 12.5 pg in 0.2 ml of hypothyroid serum. The T(3) values observed in euthyroid subjects and in patients with various thyroid diseases are as follows: euthyroid (38) 1.10+/-0.25 (SD) ng/ml, hypothyroid (25) 0.39+/-0.21 (SD) ng/ml, and hyperthyroid (24) 5.46+/-4.42 (SD) ng/ml. The levels of T(3) parallel the thyroxine (T(4)) concentration in the sera of these subjects. In eight pregnant women at the time of delivery, T(3) concentrations were in the upper normal range (mean 1.33 ng/ml). The levels of T(3) in cord serum obtained at the time of delivery of these patients (mean 0.53 ng/ml) are distinctly lower and close to the hypothyroid mean. Administration of 10 U of bovine thyroid-stimulating hormone (TSH) to euthyroid subjects causes a two-fold increase in serum T(3) levels within 8 hr. At this time, the increase in serum T(4) concentration is only 41%. In two subjects in whom thyroid secretion was acutely inhibited, one after pituitary surgery and another after thyroidectomy, the serum T(3) fell into the hypothyroid range within 1-2 days. Thus, serum T(3) concentrations appear to be a sensitive index of acute changes in thyroid hormone secretion and should prove to be a useful adjunct to both the clinical and physiological evaluation of thyroid function.


Inhibition of thyrotropin response to thyrotropin-releasing hormone by small quantities of thyroid hormones. Inhibition of thyrotropin (TSH) release by chronic treatment with small quantities of triiodothyronine (T(3)) and thyroxine (T(4)) was evaluated by determining the serum TSH response to thyrotropin-releasing hormone (TRH) in normal subjects and hypothyroid patients. Response to TRH was determined before treatment and after each dosage of a synthetic combination of T(3) + T(4) had been given for 3-4 wk. Treatment of eight normal subjects with 15 mug T(3) + 60 mug T(4) reduced the maximum increase in serum TSH above baseline (maximum DeltaTSH) by 76% in response to 400 mug TRH and by 87% in response to 25 mug TRH. The average serum T(3) level during a 24 hr period in normal subjects who had been taking 15 mug T(3) + 60 mug T(4) for 3-4 wk was 129+/-10 ng/100 ml (mean +/-SEM), well within the normal range, 70-150 ng/100 ml, although higher than the pretreatment level, 98+/-7 ng/100 ml. The average serum T(4) level was unchanged from the pretreatment level. Treatment of the same subjects with 30 mug T(3) + 120 mug T(4) reduced the maximum DeltaTSH further.Six patients with primary hypothyroidism were treated, sequentially, with 15 + 60, 22.5 + 90, and 30 mug T(3) + 120 mug T(4). For each patient there was one increase in dosage of 7.5 mug T(3) + 30 mug T(4) which abruptly converted a maximum DeltaTSH that was greater than, or at the upper limit of, normal to one that was subnormal. Concurrent with these six abrupt changes in TSH response, the mean serum T(3) level increased only from 105+/-5 to 129+/-9 ng/100 ml, and the mean serum T(4) level increased only from 4.9+/-0.8 to 6.3+/-0.5 mug/100 ml. These data demonstrate the extreme sensitivity of TRH-induced TSH release to inhibition by the chronic administration of quantities of T(3) + T(4) which do not raise serum T(3) and T(4) levels above the normal ranges.


Human prolactin and thyrotropin concentrations in the serums of normal and hypopituitary children before and after the administration of synthetic thyrotropin-releasing hormone. Synthetic thyrotropin-releasing hormone (TRH) was administered to normal children and hypopituitary patients in a dose of 7 mug/kg i.v. over 30-60 sec. Serum thyrotropin (TSH) and prolactin (HPr) concentrations were measured by radioimmunoassay before and at 15-min intervals for 2 hr after TRH. In 20 normal children HPr rose from a mean baseline value of 7.0+/-1.2 (SEM) ng/ml to a mean peak value of 39.5+/-5 ng/ml. In 11 patients with growth hormone (GH) deficiency without TSH deficiency. HPr values rose from a mean baseline of 3.6+/-0.8 ng/ml to a mean peak value of 13.9+/-2.8, a significantly less peak response as compared with normal children (P < 0.005). The TSH responses to TRH, however, were statistically indistinguishable from those of normal children. In 10 patients with GH and TSH deficiency both the mean baseline HPr levels (25.0+/-5 ng/ml) and the mean peak HPr levels after TRH (68.5+/-10 ng/ml) were significantly higher (P < 0.005 and < 0.025) than those of normal children. Similar comparisons were also true for the peak TSH responses (P < 0.05). Two panhypopituitary patients released no TSH and only small amounts of HPr after TRH. After thyroid replacement therapy in eight of the patients with GH and TSH deficiency, the mean HPr baseline levels (7.6+/-1.0 ng/ml) and peak levels (23.3+/-4.6 ng/ml) after the same dose of TRH were significantly less than their pretreatment levels (P < 0.001 and < 0.01) and were within the range for normal children. Synthetic TRH stimulates the simultaneous release of TSH and HPr in normal children and most hypopituitary patients. When the concentrations of thyroxine (T4) and triiodothyronine (T3) are low, the levels of HPr before and after TRH are elevated. After thyroid replacement therapy, HPr levels decrease to normal. T4 and/or T3 may condition the production or effects of prolactin-inhibiting factor (PIF) activity. The TSH and HPr responses after TRH in hypopituitary patients will determine whether the primary defect resides in the pituitary or hypothalamus, but cannot delineate the hypothalamic defect as a deficiency of hypothalamic hormone production or neurohumoral transmission.


Extensive microbial degradation of DDT in vitro and DDT metabolism by natural communities.


Increment-threshold spectral sensitivity in the squirrel monkey.


Stimulus information and primate discrimination learning; utilization of preresponse stimulus information following acquisition.


Studies on the purification and characterization of human factor 8. Factor VIII (antihemophilic globulin) has been prepared from Hyland method IV AHG and cryoprecipitate using limited chymotryptic digestion followed by Sepharose gel filtration. The activity of factor VIII is unaffected by the digestion procedure, while fibrinogen in converted to large noncoagulable fragments. The purified factor VIII has been found to be a macromolecular glycoprotein with a major subunit of 240,000, as shown by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. Carbohydrate analysis of factor VIII gave values of 1% sialic acid, 2.8% hexosamine, and 1-2% hexose (mannose, galactose, and fucose). The lipid content was found to be less than 5% of the protein content, and included no detectable phospholipid. The amino acid content is also reported. Immunoelectrophoretic analysis using rabbit antibody to purified factor VIII produced a single precipitin line. The chymotrypsin digestion step facilitates the preparation of factor VIII by reducing the viscosity of fibrinogen in the crude starting material, thereby increasing fivefold the quantity of material which can be processed at one time. It also improves markedly the resolution between factor VIII and fibrinogen on gel filtration.


Control of the plague vector Opisocrostis hirsutus, by treatment of prairie dog (Cynomys ludovicianus) burrows with 2 per cent carbaryl dust.


Cortical information processing of stimulus motion on primate skin.


Incubation of surviving sections of ovarian tumours as a method of testing their sensitivity to cytostatics.


Morphine-induced redistribution of cardiac output in the unanesthetized monkey.


Microbiological evaluation of decontamination procedures for hydrotherapy tanks.


Human lactational and ovarian response to endogenous prolactin release. Radioimmunoassayable prolactin rises in postpartum women during nursing and after intravenous thyrotropin-releasing hormone (TRH). Prolactin release induced by TRH can be dissociated from the postsuckling response. In addition to this, increases in endogenous prolactin secretion are followed by marked breast engorgement and milk letdown, especially after intravenous TRH. In this group of breast-feeding women, vaginal smears remained atrophic even up to 410 postpartum days. Prolactin appears to influence the production of breast milk, and the maintenance of a regular nursing pattern seems to promote the maintenance of ovarian unresponsiveness to circulating gonadotropins.


Immunization of guinea pigs against leukemia by scarification of skin with leukemic cell extracts.


A new method for elution of erythrocyte-bound antibody.


Relationship between RNA metabolism and cell cycle in acute leukaemia.


Vincristine-induced thrombocytosis studied with  75 Se selenomethionine.


Ineffective erythropoiesis in normal rats and 'early labelled' bile pigment.


Light-induced reduction in specific activity of malate enzyme in Euglena gracilis Z.


Independent regulation of hexose catabolizing enzymes and glucose transport activity in Pseudomonas aeruginosa.


Regulation of ribulose-1,5-diphosphate carboxylase by 6-phospho-D-gluconate.


Growth hormone: the effect on skeletal renewal in the adult dog. I. Morphometric studies.


Myometrial necrosis after therapeutic abortion.


Primary carcinoma of the duodenal bulb.

Primary carcinoma of the duodenal bulb.


Prevention of Rh immunization after abortion with Anti-Rh (D)-immunoglobulin. In order to investigate the incidence of Rh-immunization during a post abortion period of at least 6 months in an Rh-negative mother, Rh levels were treated in 170 Rh-negative women over a period of 6 months.  Of 48 women treated with anti-Rho (D)-immunoglobulin, none became immunized.  5 of the 122 women in the control group were actively immunized during this period.  Since the risk of immunization increases with gestation length and can occur with abortion, it is suggested that all Rh-negative women who are not already immunized to the Rh factor should receive anti-Rho (D) immunoglobulin after abortion.


Dynamics of placental and uterine blood flow. A functional index using  113m In.


Diagnostic tests in pancreatic disease.

Diagnostic tests in pancreatic disease.


Cationic proteins of human granulocytes. I. Isolation of the cationic proteins from the granules of leukaemic myeloid cells.


Tobramycin: in vitro antibacterial spectrum of a new aminoglycoside.


On the mechanism of platelet aggregation induced by heparin, protamine and polybrene.


Isolation and analysis of transferrins from different species.


Microtubule formation in vitro in solutions containing low calcium concentrations. Isolated rat brain tubulin can be repolymerized in vitro in solutions containing adenosine triphosphate or guanosine triphosphate, magnesium ions, and a good calcium chelator. The extreme sensitivity of tubulin to calcium ions explains the failure of previous efforts to obtain polymerization and suggests a possible mechanism for regulation of microtubule polymerization in vivo.


Toxicity of polychlorinated biphenyls (PCB) to goldfish.


Reconstructive laryngectomy. Report on the first 35 cases.


Dilemma of delayed radiation injury of the larynx.


Surgical correction of subglottic stenosis of the larynx. Prelimenary report of an experimental surgical technique.


Congenital multiple giant mast cell tumours with urticaria pigmentosa: malabsorption: first reported case.


Dermal dopa-positive cells in lichen planus.


Fear of strangers in children and the orienting reaction.


Stabilizing and disruptive selection on a mutant character in Drosophila. IV. Selection on sensitivity to temperature. Individual selection on temperature sensitivity was applied to the relative length of the 4th vein of the mutant ci(D-G) in four selection lines according to different selection schemes indicated in Figure 1. These selection systems include, besides the selection on temperature, disruptive selection. In all lines the disruptive component causes an increase of the phenotypic variance, but there are large differences in its composition. The selection changed temperature sensitivity in the expected direction in all lines. In one line (C-D(-)) however, the change in temperature sensitivity and the increase in variance were only small because the disruptive component and the canalizing component of the selection scheme restricted each others' effect. The results are discussed in relation to earlier results obtained by disruptive selection at one temperature.


Studies on the scutellar bristles of Drosophila melanogaster. II. Long-term selection for high bristle number in the Oregon RC strain and correlated responses in abdominal chaetae. Results are presented of 135 generations of selection for high scutellar bristle number in two lines M and M3 derived from the same original mating of one female with 5 bristles by one male with 4 bristles, the latter being the wild-type canalised phenotype. Results are also given of two relaxed lines per line and of a reselection line M2 derived from the first relaxed line of line M which had regressed almost to base population level. The effect of introducing the sc(1) allele into the M and M3 selected backgrounds was studied at generations 39-44. At the end of selection the effect of an extra dose of sc(+) was also studied in males of all selected backgrounds. The correlated responses in abdominal bristles were followed in all lines.-Considering their common origin, the selection lines differed markedly in pattern of scutellar response and in most other aspects observed, namely correlated responses in abdominals and p.c. scutellars, sex differences, and behaviour on relaxation. Selection limits for scutellar bristles in lines M and M2 were equal to or greater than the most extreme reported in the literature.-The probit span of the canalised 4 bristle class decreased in each selection line as the mean scutellar bristle number increased, and increased again in the relaxed lines as the mean bristle number decreased. In the context of an hypothesis that canalisation at 4 bristle is due to regulation of the scute locus, this result is now interpreted as being due mainly to selection for poor regulators of sc(+), in contrast to a previous interpretation that only the minor gene background was altered by selection, the canalisation (regulation) genotype not being affected.-Introducing the sc(1) allele into the selected backgrounds M and M3 showed a reduced effect on sc(1) flies compared with sc(+) flies, and an interaction of sc(1) and sc(+) with selected background. sc(1) flies had about the same number of bristles in both backgrounds though the mean of sc(+) flies in line M was about 3sigma higher than in line M3. Dominance of sc(+) to sc(1) was reduced slightly in M3. However, the effect of an extra dose of sc(+) at the end of selection was about the same as in unselected in all lines, so the first or dominance level of regulation of the scute locus was not significantly affected by selection, though the second or canalisation level of regulation was.-A large positive correlated response in abdominal bristles occurred in all lines. The response in line M was about twice that in M2 and M3 and was in fact as large as can be obtained from direct selection on abdominals. In line M some genes may have been selected with a proportionately greater effect on abdominals than on scutellars. This is supported by the further observation in line M that the abdominal scores of flies with particular scutellar bristles scores increased as the scutellar mean increased. An attempt was made to apply to these results Rendel's (1962) model of competition between scutellars and abdominals for common bristle-making resources. This could not be done satisfactorily mainly because the assumptions in the model about the similarity of effects in scute and wild-type flies were not met in the present material.


Characterization of chicken b-locus (IgG) allotypes. Chicken allotypes b1 and b2 are controlled by allelic genes and associated with the IgG class of immunoglobulins. The determinants cannot be detected on either isolated heavy and light polypeptide chains or the enzymatic fragments. The results suggest that either the intact IgG molecule is required for their expression or the conditions normally used for isolation of the subunits destroy or modify the antigenic specificities in chickens.


The clonal nature of antibody formation. II. Characteristics of antibody cell clones specific for poly-O-acetyl-D-serine and poly-D-alanine.


Antigen-induced inhibition of experimental allergic encephalomyelitis. I. Inhibition in guinea pigs injected with non-encephalitogenic modified myelin basic protein.


An unusual papain fragment containing the V H  region of an IgG3 myeloma protein.


Communications. IgD-bearing human lymphocytes.


Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses.


Surgical management of soft tissue defects of the ankle-heel region.


Renal lysosomal catabolism of staphylococcal enterotoxin B.


The effect of resections of the inferotemporal cortex or the amygdala on visual orienting and habituation.


Detection of masked patterns in monkeys with inferotemporal, striate or dorsolateral frontal lesions.


Is gastric residual carcadian?

Is gastric residual carcadian?


Quantitation of red cell carbonic anhydrases B and C and hemoglobin F in thyroid disorders.


Studies on intratypic variants of coxsackie B 1 virus.


Characteization and distribution of two new foamy viruses isolated from chimpanzees.


Growth of transmissible enteritis virus of turkeys in intestinal organ cultures.


Somatesthetic recovery following primary somatosensory projection cortex ablations.


Unitary analysis of epileptic activity in acute and chronic foci and related cortex of cat and monkey.


A segregated antigen in cartilage matrix.


Cord blood carbonic anhydrase B concentration and birth weight.


Study of macroamylase complexes.

Study of macroamylase complexes.


Measurement of nonexchangeable sodium in normal man.


Glutamate-induced brain damage in infant primates.


Spinal cord emboli in dogs and monkeys and their relevance to aortic atheroma in man.


Cancer of the head and neck. Hypopharynx and larynx. 2.


Experiences with integrated operative and radiation therapy.


Combined therapy.

Combined therapy.


Comment: operate and-or irradiate?

Comment: operate and-or irradiate?


Fractures of the ankle joint.

Fractures of the ankle joint.


Treatment of renal disease. 1. Psychological problems in long-term care.


Listeria infections after splenectomy.

Listeria infections after splenectomy.


The metabolism of carbamate pesticides--a literaute analysis. I.


The metabolism of carbamate pesticies--a literature analysis. II.


The "extraverted neurons" of the mammalian cerebral cortex.


Cytologic aspect of RF radiation in the monkey.


Facial skeletal changes after mandibular condylectomy in growing and adult monkeys.


Dietary factors that affect biological availability of trace elements.


Application of numerical methods to the taxonomy of the genus Streptomyces.


Comparative tests for diagnosis of lead poisoning.


The effect of berberine sulfate on staphylococci.


Remission of macroglobulinemia coincident with hepatitis: report of case and review of literature.


The fate of gonococci in polymorphonuclear leucocytes: an electron microscopic study of the natural disease.


Drug-induced hypoglycemia. A review based on 473 cases.


Animal models of gallstone formation.

Animal models of gallstone formation.


Relationship between bile composition and gallstone formation in squirrel monkeys.


Parenteral hyperalimentation and controlled clinical trials.


Carcinoembryonic antigen(s) in liver disease. II. Isolation from human cirrhotic liver and serum and from normal liver.


Multiple penicillin-binding components in Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Escherichia coli.


Further studies of the D-aspartic acid-activating enzyme of Streptococcus faecalis and its attachment to the membrane.


Purification and properties of rat liver tryptophan oxygenase.


Purification of N-acetylmuramic acid-L-alanine amidase from Bacillus megaterium.


Structurally defective galactose-binding protein isolated from a mutant negative in the  -methylgalactoside transport system of Escherichia coli.


The Hunter corrective factor. Purification and preliminary characterization.


Transport of dicarboxylic acids in Bacillus subtilis. Inducible uptake of L-malate.


Effect of calcium on pentagastrin-, histamine-, bethanecol-, and insulin-stimulated gastric secretion in the ferret.


Mammalian deoxyribonucleases acting on damaged DNA.


The family doctor.

The family doctor.


Bladder outlet obstruction in elderly women.


Treatment of gonorrhoea.

Treatment of gonorrhoea.


Pesticide residues in food. Report of the 1971 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Committee on Pesticide Residues.


Eye malformations in the offspring of female rabbits immunized with bovine-alpha-crystallin.


Spondylo-epiphyseal dysplasia with unusual skull changes.


Quantitation of serum proteins on whole blood--electroimmunodiffusion technique applicable to capillary blood.


Conformational change(s) induced in sheep calcium-dependent antibody upon interaction with homologous antigen. II. Analysis of antibody (Fab fragment) hydrogens blocked from exchange upon reaction with homologous antigen.


Conformational change(s) induced in sheep calcium-dependent antibody upon interaction with homologous polypeptide antigen. I. Hydrogen-exchange studies of immunoglobulin G and (Fab') 2  fragment.


Nucleoside diphosphokinase from beef heart cytosol. II. Characterization of the phosphorylated intermediate.


C1q protein of human complement.

C1q protein of human complement.


Rh-D isoimmunization.

Rh-D isoimmunization.


The combination of trimethoprim and sulfamethoxazole in the treatment of urinary tract infection. In a series of 52 patients the combination of trimethoprim and sulfamethoxazole was used for the treatment of urinary tract infection and the results are analyzed with respect to the clinical diagnosis and bacterial etiology. There was complete agreement between in vitro sensitivity and clinical response except in the case of one strain of Streptococcus fecalis. The combination of drugs was effective against some bacterial strains which were resistant to the commonly used antimicrobial agents.


Serum lactate dehydrogenase isoenzymes linked to immunoglobulin A.


Blood parasitisms of wild turkeys in the southeastern United States.


Coccidioidomycosis accompanying hepatic disease in two Bengal tigers.


Laryngeal acariasis in the chacma baboon.


Clinical evaluation of tiletamine as an anesthetic in six nonhuman primate species.


Acute amaurotic epilepsy caused by lead poisoning in nonhuman primates.


Heatstrike in a colony of squirrel monkeys.


Tuberculosis in a pig-tailed macaque.

Tuberculosis in a pig-tailed macaque.


Fluke (Gastrodiscoides hominus) infection in a Rhesus monkey.


Neuropathological effects of sodium azide administration in primates.


Technique to shorten canine teeth in young rhesus monkeys.


Endometrial adenocarcinoma, endometriosis, and pyometra in a rhesus monkey.


Odd numbered and new essential fatty acids.


Comparison of effects of methylazoxymethanol acetate on brain development in different species.


Ameloblastic odontoma in a rhesus monkey.


Effects of orally administered dichlorvos in rhesus monkeys.


Biological availability of amino acids.

Biological availability of amino acids.


A technique for vagal stimulation in chronic experiments.


Acute effects of septic shock on plasma and red cell volumes in baboons.


Identities of polychlorinated biphenyl isomers in aroclors.


Simian sarcoma virus, type 1 (Lagothrix): focus assay and demonstration of nontransforming associated virus.


Transformation of rhesus foreskin cells by Mason-Pfizer monkey virus.


Regeneration of periodontal and transseptal fibers after autografts in Rhesus monkeys: a qualitative approach.


The dentition of Papio anubis.

The dentition of Papio anubis.


Immunochemical investigation of the modal specificity of taste.


Practolol in the treatment of ischaemic heart pain. Results of a controlled trial.


Transdentinal cytotoxic effect of fluoride.


Effects of acrylic restorations on the periodontium of monkeys.


Survey of microorganisms for calcification in a synthetic medium.


Hyaluronic acid and replacement of vitreous and aqueous humor.


Chemical residues in Lake Erie fish--1970-71.


Residues of organochlorine pesticides, polychlorinated biphenyls, and mercury in bald eagle eggs and changes in shell thickness--1969 and 1970.


Carbamazepine (tegretol) in the long-term treatment of grand mal epilepsy.


Chemotherapy in superficial neoplasms of the bladder.


The influence of a combined oral contraceptive on the absorption of iron.


Decrease in platelet surface charge during phagocytosis of polystyrene latex particles or thorium dioxide.


Bone regeneration in maxillary defects. An experimental investigation on the significance of the periosteum and various media (blood, surgicel, bone marrow and bone grafts) on bone formation and maxillary growth.


A clinical approach to fluid therapy in dogs.


Subcellular valves and canaliculi in arterial endothelium and their equivalence to so-called stigmata.


Cytoplasmic and nuclear growth during the proliferation of Ehrlich ascites tumour cells in mice.


Circadian rhythms in hairless mouse epidermal DNA-synthesis as measured by double labelling with H3-thymidine (H3Tdr.).


The deposition of silver in glomerular basement membrane.


Phases of antibody production in immunoactive cells established by immunofluorescence method.


Changes of blood oxygen affinity and capacity and red cell 2,3-diphosphoglycerate evoked by exchange transfusions with ACD preserved blood in newborn infants: their interrelationship and influences on oxygen supply of tissues and erythropoiesis.


Cytomorphological and cytochemical studies of the uropygial gland of the scorbutic bulbul, Pycnonotus cafer.


Histochemical demonstration of bismuth and lead in some tissues of common ground squirrel Funambulus pennanti (Wroughton).


Histochemical analysis of sperm.

Histochemical analysis of sperm.


Histochemical localization of alkaline phosphatase in the spermathecae of the earthworm, Barogaster annandalei (Stephenson).


Electronhistochemical observations on the localization of sodium ions in glomerular basement membrane.


Pancreatic transductal electrolyte flux. Effect of EDTA.


The effect of rifampicin on Pseudomonas keratitis.


The kinetics of lymphoid cell proliferation in the tuberculous mouse spleen.


Monkey to human transfer of delayed hypersensitivity in vitro with RNA extracts.


Conversion of homozygous lymphoid cells to produce IgM antibodies and IgG immunoglobulins of allelic light-chain allotype by injection of rabbits with RNA extracts.


Clinical survey of pigeon breeders.

Clinical survey of pigeon breeders.


A colorimetric technique for the demonstration of L-asparaginase in electropherograms.


Clinical significance of abnormally shaped IgM arcs in serum immunoelectrophoresis.


Studies on the response of patients with classic hemophilia to transfusion with concentrates of antihemophilic factor. A difference in the half-life of antihemophilic factor as measured by procoagulant and immunologic techniques. Antihemophilic factor (AHF, factor VIII) levels were measured by a standard coagulation method and by an immunologic technique before and after infusion of AHF concentrates into patients with classic hemophilia. After infusion of AHF concentrates, the half-life of the AHF procoagulant (i.e., clot-promoting) activity varied from 12 to 14 hr, whereas that of the antigen ranged from 24 to 40 hr. The half-life of the antigen was similar in patients with and without circulating anticoagulants to AHF. The data are compatible with the suggestion that the antigen may be carried on a precursor molecule which the patient with hemophilia produces but cannot convert to the functional clot-promoting agent. Other explanations of the observations are, however, recognized.


Cholesterol metabolism and placental transfer in the pregnant Rhesus monkey. The placental transfer of cholesterol (5-cholesten-3beta-ol) was investigated by giving pregnant rhesus monkeys cholesterol-1alpha-(3)H or cholesterol-4-(14)C and then determining the cholesterol specific activity (SA) in maternal serum and in fetal serum and tissues. An isotopic steady state was established in five pregnant animals by the daily feeding of a tracer dose of cholesterol-4-(14)C. Comparison of maternal and fetal serum cholesterol SA revealed that an average of 42.6% of the serum cholesterol in the term fetus originated by transfer from the maternal blood. The remainder presumably arose by fetal synthesis de novo. Fetal tissues had cholesterol SA equal to or slightly less than that of fetal serum, except for brain which had a SA only 5% that of fetal serum. In other studies a single intravenous dose of radioactive cholesterol was given to either mother or fetus in late pregnancy. The time for detectable passage across the placenta in either direction was between 4 and 24 hr. With maternal administration of the isotope, there was equilibration of maternal and fetal serum cholesterol SA after 10-12 days. With fetal injection of isotopic cholesterol, however, the maternal cholesterol SA never attained a level more than 5% of fetal SA. This indicated that the net cholesterol flux was strongly in the direction of mother to fetus. Serum cholesterol levels were significantly greater in maternal than in fetal serum (80.3+/-18.5 vs. 59.6+/-15.6 mg/100 ml). Maternal serum cholesterol concentration in the monkey was significantly lower in late pregnancy than during the puerperium. Studies of breast milk indicated that approximately two-thirds of milk cholesterol was transferred from the maternal blood.


Carbonic anhydrase function and the epithelial organization of H+ secretion in turtle urinary bladder. The function of carbonic anhydrase in H(+) secretion by the turtle bladder was studied in vitro. Dose response curves were obtained for the carbonic anhydrase inhibitors, acetazolamide and ethoxzolamide, with and without addition of CO(2) to the system. In addition, carbonic anhydrase was assayed in homogenates of mucosal cells. The activity in the homogenates was 155+/-16 U/g dry wt, of which only 11 U represented contamination from erythrocytes; after addition of 5 x 10(-6)m acetazolamide, no enzyme activity was detectable. In the intact preparation free of exogenous CO(2), the dose response curve for acetazolamide showed two plateaus of inhibition, one at 50% and one at more than 80% inhibition. At 50% inhibition (from 5 x 10(-6) to 5 x 10(-5)m acetazolamide), H(+) secretion was restored or enhanced by CO(2) addition to the same extent as bladders not exposed to acetazolamide. At concentrations of more than 1 x 10(-4)m, H(+) secretion was no longer restorable by CO(2). Unlike acetazolamide, ethoxzolamide caused progressive inhibition of H(+) secretion in the CO(2)-free system. The maximal extent of inhibition with ethoxzolamide and the behavior of inhibition in the presence of 2.5% CO(2) were the same as for acetazolamide. Evidence is presented that all surface epithelial cells secrete H(+) and generate OH(-) within the cell interior. The capacity of cells to dispose of OH(-) by CO(2) hydroxylation varies with the availability of cytoplasmic carbonic anhydrase. A small population of cells contains abundant carbonic anhydrase and secretes at high rates even when CO(2) is in short supply. On the basis of these results and histochemical data on the distribution of carbonic anhydrase within the mucosa, an analysis is presented of the epithelial organization of acidification by the turtle bladder.


Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes. Spleen cells from LAF(1) mice hyperimmune to sheep erythrocytes (SE) lost their ability to transfer a secondary response to irradiated recipients after incubation with anti-theta and rabbit complement in vitro. Small numbers of specific immune cells even when taken 3 days after a primary SE injection reconstituted the direct and indirect plaque-forming cell responses. Larger numbers of cells sensitized to B. abortus (or keyhole limpet hemocyanin), and given together with the corresponding antigen, also partially reconstituted the ability to respond to SE. This property was mediated by theta-bearing cells and was interpreted as due to a nonspecific humoral factor liberated by specifically activated T cells and acting on B cell proliferation or maturation.


Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study. Arteriosclerotic lesions have been produced in monkeys (Macaca nemestrina) by selective removal of the vascular endothelium with an intra-arterial balloon catheter. Immediately after de-endothelialization a platelet layer covers the denuded area. This thrombus is gradually removed and by 7 days the vessel appears to be largely reendothelialized. Beginning at day 4, smooth muscle cells undergo modification and migrate through fenestrae in the internal elastic lamina into the intima where they proliferate. By 28 days, the intimal lesion consists of multiple layers of smooth muscle cells surrounded by collagen and elastic fibers and basement-like material. After 3 months the lesions are markedly hyperplastic and contain new extracellular connective tissue elements. In contrast, with no further injury after 6 months the lesion has decreased markedly in size suggesting that it may be reversible in the absence of continued endothelial injury. The importance of endothelial "injury" exposing medial smooth muscle to plasma constituents may be the principal factors associated with the migration and proliferation of the smooth muscle cells into the intima resulting in the lesion. The smooth muscle cells do not contain lipid. The similarities of this lesion to the fibromusculo-elastic lesion or preatherosclerotic intimal hyperplasia in man makes it a useful model for the further study of atherosclerosis.


Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography. The fate of different complexes on the membrane of thymocytes and spleen lymphocytes was studied with the use of both immunofluorescence and ultrastructural radioautography. The complexes of anti-immunoglobulin (Ig) with the surface Ig of B lymphocytes were present all around the membrane at 4 degrees C; an increase in temperature produced a rapid aggregation of the complex into a cap which was readily interiorized in vesicles. Ultrastructural details of this process were given. The movement of the complexes depended upon the amount of anti-Ig and the temperature. The complexes of anti-lymphocyte antibody with surface antigen(s) did not result in formation of a single large aggregate (or cap) unless an anti-antibody was brought into the reaction. The caps formed by this trilayered complex were not interiorized. Concanavalin A (Con A) bound to cell surface carbohydrate moieties and the complexes of Con A readily formed a cap and were interiorized. Finally, antibodies to H-2 determinants did not form in most instances a single cap aggregate even when anti-antibodies were used. With time the H-2 complexes tended to form several large aggregates with some endocytosis.


Acute respiratory failure in the adult. 2.


Double-blind trial with sulfamethoxazole plus trimethoprim (Bactrim) versus demethyl-chlortetracycline (Ledermycin) in chronic respiratory tract infections.


Volume analysis of human peripheral blood leukocytes.


The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers.


Does LSD induce chromosomal damage and malformations? A review of the literature.


The metabolic fate of  -sulphobenzylpenicillin in rats.


The metabolism of a new schistosomicide 2-isopropylaminomethyl-6-methyl-7-nitro-1,2,3,4-tetrahydroquinoline (UK 3883).


Animal models of atherosclerosis.

Animal models of atherosclerosis.


Effects of amyl nitrite on coronary arterial blood flow velocity in man.


Coronary artery disease. Antidote to a stereotype.


Surgery for coronary artery disease.

Surgery for coronary artery disease.


Congenital pit of the optic disc with acquired retinal cyst.


Intravenous hyperalimentation: a review of two and one-half years' experience.


Central venous nutrition in severe tetanus.


Survival of Pseudomonas aeruginosa in the peritoneal cavity of mice treated with antilymphocyte serum.


Hageman trait (factor XII deficiency): a probably second genotype inherited as an autosomal dominant characteristic.


Thrombotic thrombocytopenic purpura: report of a case with possible immune etiology.


Cellular handling of antigen following injection into neonatal rabbits.


The gastroenterological manifestation of Chagas' disease.


Parenteral hyperalimentation in management of gastrointestinal fistulas.


Use of implantable telemetry systems for study of cardiovascular phenomena.


Immunological reactions in chimpanzees experimentally infected with Schistosoma japonicum.


Effect of chemical modification of lysine residues on the conformation of human immunoglobulin G.


Serologic estimation of thymine dimers in the deoxyribonucleic acid of bacterial and mammalian cells following irradiation with ultraviolet light and postirradiation repair.


A deoxyribonucleic acid polymerase I-deficient mutant of Bacillus subtilis.


Regulation of aromatic amino acid biosynthesis in Bacillus subtilis 168. I. Evidence for and characterization of a trifunctional enzyme complex.


Disodium cromoglycate. A new drug for prevention of bronchial asthma.


Ultrathin longitudinal sections of single myelinated fibres for electron microscopy.


Changes in cerebral vasomotor reactivity to CO 2  and autoregulation following experimental subarachnoid hemorrhage.


Cerebral hemodynamic and metabolic changes after experimental subarachnoid hemorrhage.


Effect of glycerol and intracarotid phenoxybenzamine on cerebral hemodynamics and metabolism after experimental subarachnoid hemorrhage.


Rate and extent of absorption of the fatty acids of fully esterified glycerol, erythritol, xylitol, and sucrose as measured in thoracic duct cannulated rats.


Studies on riboflavin deficiency in Tetrahymena pyriformis.


Phagocytic function of reticuloendothelial system in protein deficiency--a study in rhesus monkeys using  32 P-labeled E. coli.


Studies on the transmission of simian malaria. V. Infection and transmission of the B strain of Plasmodium cynomolgi.


Taxonomy, prevalence, and experimental transmission of a protozoan parasite, Trichodina oviducti Polyanskii (Ciliata: Peritrichida) of the thorny skate, Raja radiata Donovan.


In vitro cultivation of plasmodium malariae.


Cessation of growth hormone secretion associated with acute elevation of the serum-free fatty acid concentration.


Effects of an experimental viral infection on plasma lipid and lipoprotein metabolism.


Radiotherapy treatment simulators and automation. A case for their provision from a cost viewpoint.


Dose distributions about 137Cs sources in tissue.


Use of a solid-state probe to detect changes in operating parameters of an 8 MV linear accelerator.


Nutrition and human constitution.

Nutrition and human constitution.


The development of our knowledge of protein deficiency in man.


Biological and disease patterns in South African inter-racial populations as modified by rise in privilege.


Evaluation and standardization of an agglutination test for human listeriosis. Human sera from patients with culturally confirmed listeriosis were tested for immunoglobulin M (IgM) and immunoglobulin G (IgG) agglutinating antibodies with trypsinized antigens of Listeria monocytogenes, Streptococcus faecalis, and Staphylococcus aureus. The response of humans to listeria infections is mainly IgM rather than IgG as found in animals. The antigens prepared from L. monocytogenes serotypes 1a, 1b, 2, 4b, and 4d were evaluated for specificity with normal sera, sera from patients with various other diseases, and sera from patients with listeriosis. The trypsinized antigens appeared to be specific for listeria antibodies with a cross-reaction rate of from 5.4 to 6%. Cross-reaction with S. aureus can be eliminated by absorption of the serum with S. aureus. This agglutination technique appears to be applicable for diagnostic testing, but, as with all serological procedures, both acute and convalescent sera should be tested.


Indirect fluorescent-antibody and quantitative agar-gel immunodiffusion tests for the serological diagnosis of paracoccidioidomycosis. The value of various serological tests in the diagnosis of paracoccidioidomycosis was studied. Quantitative agar-gel immunodiffusion and indirect immunofluorescent tests were performed, and the results were compared with those of complement fixation and qualitative agar-gel procedures. The quantitative immunodiffusion procedure was found to serve as the simplest and safest quantitative test that could be performed for evaluation purposes, whereas the indirect fluorescent-antibody test gave nonspecific reactions and, as such, proved unsuitable.


Use of acetamide broth in the isolation of Pseudomonas aeruginosa from rectal swabs. Acetamide broth, used in conjunction with ultraviolet light scanning, was superior to Pseudosel agar in the recovery of Pseudomonas aeruginosa from rectal swabs both in time of recognition and total positive isolations.


Influence of sodium chloride on growth of Neisseria meningitidis. Nasopharyngeal isolates of Neisseria meningitidis were tested for growth on nutrient agar with and without the addition of 0.8% sodium chloride. Of the 822 strains tested, 1.3% grew on the salt-free medium, and 74.1% grew on the medium supplemented with sodium chloride.


Indirect hemagglutination test for chlamydial antibodies. An indirect hemagglutination (IHA) test is described for chlamydial antibodies in psittacosis diagnostic sera; for this test tanned sheep erythrocytes sensitized with a deoxycholate extract of Chlamydia psittaci grown in Vero cell monolayers were used. Adaptation of the IHA test to the Microtiter system decreased sensitivity; nevertheless, the Microtiter-IHA test was more sensitive than the complement fixation test. Lymphogranuloma venereum antibodies also were detected by using antigen extracted from C. psittaci.


Efficiency of a transport medium for the recovery of aerobic and anaerobic bacteria from applicator swabs. The survival of four aerobic and four anaerobic pathogens was evaluated quantitatively on cotton swabs and calcium alginate swabs stored in dry tubes as compared with swabs stored in Amies Transport Medium without charcoal. Survival of the pathogens was markedly improved when stored in Amies Transport Medium, although there was considerable loss of viability after a few hours of storage.


Problems in the laboratory isolation of simian hemorrhagic fever viruses and isolatse metaboli enterobacteriaceae classificat  enterobacteriaceae enzymology hydrogen peroxide metaboli enterobacteriaceae metaboliion of the agent responsible for the Sussex-69 epizootic. At least six epizootics of simian hemorrhagic fever have occurred at four different primate centers. Although these diseases could easily be transmitted to other monkeys of the Macaca species, difficulty has been encountered in isolating the causative virus in cell culture. The results of this study have shown that the isolation of simian hemorrhagic fever virus strains in cell culture is dependent upon the use of a susceptible MA-104 cell strain and that the ability of such strains to support the replication of these viral agents may vary. By using this information we have been able to isolate a viral agent in cell culture from materials derived from the Sussex/69 epizootic.


Detection of Chlamydia psittaci by immunofluorescence. A direct fluorescent-antibody (FA) test was developed to detect Chlamydia psittaci in dural impressions from specimen-inoculated mice. Technical procedures for the test were compared. C. psittaci was found in mice after infection as early by the FA technique as it was by cytochemical staining methods usually used. The lymphogranuloma venereum organism was also stained by conjugated antibody to C. psittaci. A distinctive advantage of the described FA test is that organisms are identified immunologically as members of the genus Chlamydia simultaneously with their detection.


Growth of a photoautotroph, Plectomema boryanum, in the dark on glucose.


Immunological relationships of Candida albicans and its transformants to Actinomycetales.


The influence of growth conditions and isolation procedures on the proteolytic breakdown of ribosomal proteins from Myxobacter 495.


Characteristics of nitrogenase activity in broken cell preparations of the blue-green alga Gloeocapsa sp. LB 795.


Partial purification and characterization of an aspartate racemase from Streptococcus faecalis.


Metabolic pathways in Tetrahymena. Estimation of rates of the tricarboxylic acid cycle, glyoxylate cycle, lipid synthesis, and related pathways by use of multiple labeled substrates.


On the measurement of protein turnover in animal cells.


Characterization of the chromosomally mediated penicillinase in Klebsiella pneumoniae.


Studies on the mechanism of the onset of proteinuria in aminonucleoside nephrosis.


Vitamin E nutrition in the Rhesus monkey. 1.


The urophysial hydrosmotic factor of fishes. 3. Survey of fish caudal spinal cord regions for hydrosmotic activity. 1.


Possible alternate routes in the metabolism of betahistine in the rabbit.


Physiologic effects of passive hyperventilation on oxygen delivery and consumption. 1.


Renal clearance investigations with  51 Cr-EDTA and  125 I-hippuran.


In vitro comparison of actinobolin and other antibiotics used in the treatment of periodontal disease and dental caries. 1.


Optimal intravesical dosage of thio-tepa in the prophylaxis of recurrent bladder papillomatosis.


Separate renal function in man determined by a combined procedure using a dye-dilution method and radioisotopes.


Two causes of hypertension in a subject with generalized neurofibromatosis.


Polychlorinated biphenyl residues: accumulation in Cayuga Lake trout with age. The concentration of polychlorinated biphenyls was shown to progressively increase with maturity in a series of lake trout. The presence of these compounds was determined by column chromatographic isolation, specific detector gas chromatography and mass spectrometry. The relation between fish age and the concentration of polychlorinated biphenyls was highly significant.


Neisseria gonorrhoeae: experimental infection of laboratory animals. Experimlental Neisseria gonorrhoeae infections were established in five species of small laboratory animals (rabbits, guinea pigs, hamsters, mice, and rats) after subcutaneolusly implanted chambers were inioculated with gonococci. The chamber fluid was easily available for study or culture. A systemic immune response was indicated by hemnagglutination assay.


Osteomyelitis of both femora in a patient on maintenance hemodialysis with severe uremic osteopathy.


The ultrastructure of medulloblastoma in tissue culture.


The periods of determination of cardiac malformations.


Distribution of acetyl cholinesterase in the hippocampal region of the guinea pig. 3. The dentate area.


Effect of L-glutaminase on transformation and DNA synthesis of normal lymphocytes.


The effect of serum protein fractions of the newborn on the thrombocytopoiesis of mice.


Early splenectomy in the management of thalassemic children in Djakarta.


Splenic histiocytosis associated with thrombocytopenia.


Changes in eosinophil granulocyte kinetics in severe hypoxia.


Double isotope silution derivative technique for measurement of catecholamines.


Serum transferrin and ceruloplasmin concentrations in patients with carcinoma, melanoma, sarcoma and cancers of haematopoietic tissues.


Distribution of L- and M-type pyruvate kinase between parenchymal and Kupffer cells of rat liver.


Utricular ablation and dysequilibrium in squirrel monkeys.


Histochemical characteristics of normal middle ear mucosa.


Hyperalimentation in infancy. Experiences at the Maine Medical Center.


Studies on inherited antigenic variation of human serum  -lipoprotein by passive hemagglutination. IV. Studies on the antibodies in two non-precipitating sera.


Chlorhexidine solutions in histological and histochemical techniques.


Current trends in gastroscopy.

Current trends in gastroscopy.


Role of smoking in floor of the mouth leukoplakias.


Reactive lesions of the gingiva.

Reactive lesions of the gingiva.


Quantitative determination of D-dopa present in levodopa samples.


Cell-mediated immune responses in oral disease: a review.


Leptospira serotype kremastos of bovine origin.


Double strandedness of ribonucleic acid of bovine ephemeral fever virus.


The health of Israel: preventive medicine in a developing society.


Will improved nutrition help to prevent mental retardation?


The key role of nutritional factors in the prevention of coronary heart disease.


Penicillin V concentration in dental alveolar blood after tooth extraction.


Effect of extreme calcium deprivation on degree of mineralization of alveolar bone, dentin and enamel in rats.


Estimation of bone marrow blood flow with  113m In-EDTA chelate and  133 Xe.


A case of thrombasthenia with a study of platelet aggregation by hydrogen peroxide (H 2 O 2 ).


Effects of saline and colloid resuscitation on renal function.


Prenatal development of the ductus epididymidis in the rhesus monkey. The effects of fetal castration.


Of eggs and follicles.

Of eggs and follicles.


Glial hamartoma of the retina in generalized neurofibromatosis, Von Recklinghausen's disease.


Abdominal tuberculosis.

Abdominal tuberculosis.


Neuraminidase of Corynebacterium diphtheriae: isolation, purification and some characteristics.


The antigenic structure of Francisella tularensis. II. Fractionation of the ether antigen on cellulose carriers and by gel filtration.


Regulation of the formation of proteinases in Bacillus megaterium. V. Characterization of two megaterioproteinases differing in the control of their synthesis.


Cerebral blood flow evaluation of prolonged experimental vasospasm.


11,15-Epiprostaglandin E 2  and its enantiomer. Biological activity and synthesis.


Spinal abscess due to Listeria monocytogenes in a patient with hepatic cirrhosis.


Tuberculin sensitization with an acidic residual protein and purified wax of tubercle bacillus.


Regulation of acetohydroxyacid synthetase in Bacillus subtilis.


Temperature-sensitive mutants of B. subtilis defective in deoxyribonucleotide synthesis.


An acceptor-dependent polyglycerolphosphate polymerase. A method for the extraction of polyglycerolphosphate polymerase from Bacillus subtilis membranes is described. Further purification by ion-exchange chromatography yields an enzyme fraction totally dependent on the addition of a heat-stable factor for activity. This factor was isolated from cell membranes and acts as an acceptor of glycerolphosphate units. The acceptor contains glycerolphosphate, glucosamine, and fatty acids, but its precise chemical structure has not yet been elucidated.


H 2 CO 3  as substrate for carbonic anhydrase in the dehydration of HCO 3 . Carbonic anhydrase, a metalloenzyme containing one zinc atom per protein molecule of molecular weight 30,000, catalyzes the interconversion of CO(2) and HCO(3) (-) in solution. The rate of catalysis, among the fastest known, is pH-dependent, with a pK(Enz) near neutral. Arguments are presented to show that: (i) only the high-pH form of the enzyme is active both for the hydration and dehydration reactions (ii) at high pH there is an H(2)O ligand on the metal (not an OH(-) as is often argued), and (iii) the substrate for the dehydration reaction is the neutral H(2)CO(3) molecule. The arguments are based on data in the literature on the nuclear relaxation rates of Cl(-) ions and water protons in solutions of carbonic anhydrase, on strict application of the principle of microscopic reversibility, and on kinetic considerations. It has been argued that H(2)CO(3) cannot be the substrate for the dehydration reaction because the observed CO(2) production rate is somewhat faster than the maximum rate at which H(2)CO(3) molecules can diffuse to the active site of the enzyme. However, current models that consider HCO(3) (-) as the substrate implicity require that protons diffuse to the enzyme at an even greater rate, well outside the limitations imposed by diffusion. We consider two mechanisms to obviate the diffusion limitation problem, and conjecture that at high substrate concentration, H(2)CO(3) reaches the active site by collision with the enzyme molecule, and subsequent surface diffusion to the active site. At lower substrate concentrations, corresponding to [HCO(3) (-)] <1 mM, generation of H(2)CO(3) molecules near the enzyme by the recombination reaction H(+) + HCO(3) (-) --> H(2)CO(3) can supply an adequate flux of substrate to the active site.


Modulation of cell behavior in vitro by the substratum in fibroblastic and leukemic mouse cell lines. Fibroblastic and leukemic mouse cell lines were cultivated on a bovine serum albumin polymer covered with basic or acidic substances. Contact inhibition of fibroblast movement (cell overlapping) and division varied depending on prior treatment of the albumin polymer. The leukemic cells, which normally grow in suspension, attached and spread out on the polymers and could be carried as a monolayer. Preparation of surfaces capable of modulating different parameters of cell behavior in vitro is thus possible.


Prokaryotic algae associated with Australian proterozoic stromatolites. Five instances of association between distinctive stromatolites and blue-green algal nannofossils are recorded from a 100-m sequence of carbonate rocks about 1.6 x 10(9) years old, along the south side of Paradise Creek, northwestern Queensland, Australia. No eukaryotes were identified in any of these systematically limited assemblages, although they are known from rocks as old as 1.3 x 10(9) years in eastern California. Thus, eukaryotes may not have appeared until after 1.6 x 10(9) years ago (but before 1.3 x 10(9) years ago). The associations observed would also be consistent with (but do not prove) a biotic influence on stromatolite morphology. As is usual among prePaleozoic forms described, the morphology of the nannofossils is very similar to living forms, displaying marked evolutionary conservatism. Primary orientation of stromatolitic laminae and columns is not invariably convex upward, as conventionally believed, but convex away from and parallel to the initial point or surface of attachment, which may be horizontal or even downward beneath overhangs.


Factors affecting the biosynthesis of mitomycins by Streptomyces caespitosus.


Bacteria isolated from cutworms and their infectivity to Agrotis spp. (Lepidoptera, Noctuidae).


Alumina--atached spores of Bacillus stearothermophilus for the control of sterilization process.


A biochemical study of alkaline phosphatase in isolated rat incisor odontoblasts.


Purification and properties of serum albumin from Rana catesbeiana.


The myoglobin of primates. II. Pan Troglodytes (chimpanzee).


Optical properties of bilirubin-serum albumin complexes in aqueous solution. I. Dependence on pH.


Gonorrhoea in the chimpanzee. Infection with laboratory-passed gonococci and by natural transmission.


Sulphamethoxazole-trimethoprim in the treatment of gonorrhoea.


Chloramphenicol resistance in the typhoid bacillus.


The effect of ketamine and phencyclidine on muscle activity in nonhuman primates.


Classification and definition of protein-calorie malnutrition.


Continuous intragastric milk feeds in infants of low birth weight. In a feeding trial 66 infants of low birth weight received continuous intragastric milk feeds from the fourth hour of life, starting with 60 ml/kg/24 hr and reaching a maximum of 300 ml/kg/24 hr on the ninth day. Each infant received only full-strength milk, which was either expressed human breast milk or SMA-S26 (a proprietary low-protein adapted cows' milk) or half-cream Regal milk (partly-skimmed evaporated cows' milk). For various reasons 10 babies had to be withdrawn, and the final assessment was made on the 56 who completed the trial successfully.Persistent vomiting was a problem in only four infants. In two of them the trial was continued after gastric lavage and in the other two vomiting stopped when the volume was reduced. Despite a careful search no evidence was found of aspiration of feeds in any infant. Continuous intragastric milk infusion was shown to be a safe method of feeding infants of low birth weight and SMA-S26 was almost as well tolerated as human milk. Because of the high-protein content of half-cream cows' milk preparations and the resultant high plasma amino-acid levels when they are given in these large volumes they should be avoided for this type of feeding although they produce better weight gains in the first week of life.


Enzymatic determination of structure of singly branched hexaose dextrins formed by liquefying  -amylase of Bacillus subtilis.


Observations on folate absorption with particular reference to folate polyglutamate and possible inhibitors to its absorption. A test system for detection of inhibitors to the enzyme which removes the glutamic acid peptide chain from folate polyglutamates (folate conjugase) is described. This utilizes the reaction between plasma conjugase and the folate polyglutamate in red blood cell haemolysate. Diphenylhydantoin and yeast extracts did not inhibit plasma conjugase. The better absorption of monoglutamate forms of folate as compared to polyglutamate forms was confirmed. Polyglutamates were absorbed normally by patients with pernicious anaemia, suggesting that conjugase enzymes (optimally active at pH 4.5) did not normally function to a significant extent in the gut lumen. Diphenylhydantoin and bicarbonate did not interfere with absorption of either mono- or polyglutamate forms of folate.


Structure of pyocin R. II. Subunits of sheath.


Hemocyanin from Dolabella auricularia. IV. Dissociation by DEAE-cellulose.


Studies on biosynthesis and morphogenesis of R-type pyocins of Pseudomonas aeruginosa. II. Biosynthesis of antigenic proteins and their assembly into pyocin particles in mitomycin C-induced cells.


Naturally occurring antibodies against colicines in human sera.


Relationship of structures and microbiological activities of the 16-membered macrolides.


Preparation of phage-free pyocin extracts for use in the typing of Pseudomonas aeruginosa.


Distribution and significance of candida precipitins in sera from pregnant women.


Action of ethylenediaminetetra-acetic acid (EDTA) on carbenicillin-resistant strains of Pseudomonas aeruginosa.


Effects of gastric antibodies on gastric secretion. I. Production of rabbit antibodies against rat gastric mucosa and gastric juice.


Separation and characterization of some ribonucleic acids from imaginal discs of Drosophila melanogaster.


Plexiform neurofibromatosis of the spine.


Carrier state prevalence of hepatitis associated antigen (AU-SH) in Nigeria.


Mathematical theory of complex ligand-binding systems of equilibrium: some methods for parameter fitting.


Radioimmunoassay for ribosomes.

Radioimmunoassay for ribosomes.


Isolation and characterization of mouse serum alpha 1-antitrypsins.


Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection.


Aromatic thiol esters as substrates in quantitative esterase determinations.


Discontinuous polyacrylamide gel electrophoresis of RNA.


Fluorescence of bacteriochlorophyll as related to the photochemistry of chromatophores of photosynthetic bacteria.


Kinetics of the fluorescence change and P8 70  bleaching in chromatophores from Rhodospirillum rubrum.


5'-deoxyadenosylcobalamin-dependent ribonucleotide reductase: a survey of its distribution.


Phosphorus and proton nuclear magnetic resonance studies in sarcoplasmic reticulum membranes and lipids. A comparison of phosphate and proton group mobilities in membranes and lipid bilayers.


The effect of ouabain on sodium transport and metabolism of the toad bladder.


Studies of membrane formation in Tetrahymena pyriformis. V. Lipid incorporation into various cellular membranes of stationary phase cells, starving cells, and cells treated with metabolic inhibitors.


Factor VIII (antihaemophilic factor) in tissues detected by antibody neutralization.


Foreign-body perforation of a jejunal diverticulum.


Mesenteric neurofibromatosis in childhood.


Immunological control schistosomiasis.

Immunological control schistosomiasis.


Long-term trial of disodium cromoglycate and isoprenaline in children with asthma. A year-long double-blind trial was carried out in 53 asthmatic children with severe perennial symptoms who were not receiving corticosteroids or corticotrophin. The treatment group were given disodium cromoglycate with isoprenaline (Intal Co.) while the placebo group were given lactose with isoprenaline four times daily. The groups were closely matched for clinical, physiological, and immunological features. Evaluation was based on the use of a diary and clinical and physiological investigations, including exercise tests.After one year 71% of the treatment group were still well controlled while 76% of the placebo group had dropped out because of inadequate control of symptoms. There was no rise in the rate of failure towards the end of the trial period and there were no seasonal variations in the failure rate. No important toxic effects were noted. It was impossible to predict the outcome of the trial in any given patient from his clinical, physiological, or immunological status at the beginning. However, the prevention of exercise-induced asthma by premedication with disodium cromoglycate in a laboratory exercise test did correlate well with the satisfactory clinical response to the drug.


Subclinical Brucella infection in man.

Subclinical Brucella infection in man.


Age effects on forebrain commissure section and interocular transfer.


Production of the placental-type alkaline phosphatase isoennzyme by lung cancer tissue.


Antitumor activity of haloacetylphenothiazines against ascites sarcoma-180.


Immunohistological studies on intestinal mucosaspecific glycoprotein in gastric carcinoma.


Immunoelectroosmophoresis in the diagnosis of meningococcal infections. Specimens of cerebrospinal fluid and serum from 22 cases of meningococcal infection were examined by immunoelectroosmophoresis and the results compared with those obtained by microscopy and culture. The results were the same except that three of 10 cases of group B infection were not diagnosed by immunoelectroosmophoresis and two of 10 cases of group C infection were not diagnosed by culture. The sensitivity of the method depends on the potency of the antiserum used and antisera from commercial sources were satisfactory except for those prepared against group B meningococci. The method may be more sensitive than microscopy and culture under certain conditions, in particular, where the patient has already begun antibiotic treatment, where the specimens have become contaminated and, where the infecting organism is either a group A or group C meningococcus.


Serum  -macroglobulins in renal disease and preeclampsia. The serum levels of alpha(2)-macroglobulin and pregnancy-associated globulin (another alpha-macroglobulin) have been measured by means of a radial immunodiffusion technique in (1) renal disease with and without proteinuria, (2) in age- and sex-matched controls, (3) in preeclampsia with and without proteinuria, and (4) in normal pregnant controls. There are significant increases in alpha(2)-macroglobulin and pregnancy-associated globulin in renal disease accompanied by proteinuria but normal levels are found in renal disease without proteinuria. Compared with normal pregnancy, alpha(2)-macroglobulin is significantly raised in preeclampsia with proteinuria but normal in preeclampsia without proteinuria. In contrast, serum pregnancy-associated globulin is significantly reduced in preeclampsia both with and without proteinuria when compared with normal pregnancy.


Immunoglobulin and intrinsic factor antibody in the sera of patients with pernicious anaemia.


DNA of ciliated protozoa. 3. Binding of RNA polymerase and denaturation at the ends of the low-molecular weight DNA in Stylonychia.


Visualization of reinitiated chromosomes in Bacillus subtilis.


A direct intercomparison of two whole-body monitors in the measurement of the absorption of an oral dose of vitamin B 12  labelled with  57 Co and  58 Co.


The physical causation of disease.

The physical causation of disease.


Foetal sulphoglycoprotein antigen (FSA) as a possible precursor of alimentary canal cancers.


Laboratory diagnosis of mumps by immunofluorescence on experimentally inoculated cell cultures.


Propsects for national health legislation.


The future of otolaryngology.

The future of otolaryngology.


Investigation of effect of various agents on periosteal bone formation.


[Phycomycoses in animals in the tropics].


Epidemiology of African histoplasmosis.

Epidemiology of African histoplasmosis.


Distribution of DOPA-2- 14 C in relation to DOPA-1- 14 C (carboxyl- 14 C-labelled DOPA) in mice before and after inhibition of DOPA-decarboxylase, studied by whole-body autoradiography.


Presence of colipase in a congenital pancreatic lipase deficiency.


Satellite deoxyribonucleic acid in Pseudomonas aeruginosa.


Extracellular neuraminidase of Streptomyces albus.


Lysine control of penicillin biosynthesis.


Production of pectolytic and macerating enzyme by Phoma strasseri.


A method of preparing rabbit leukocytes for use in the capillary-migration test. Studies using particulate and soluble-sensitizing antigens.


Cultivation and properties of Neisseria sp. grown in chemically defined media.


Mutants of Bacillus cereus strain T that produce thermoresistant spores lacking dipicolinate and have low levels of calcium.


An approach to quantitative antibiotic sensitivity testing for some gram-negative pathogens.


the significance of pattern variations in pyocine typing of Pseudomonas aeruginosa.


Degradation of rutin by Aspergillus flavus. Quercetinase: isolation of a low molecular-weight form containing less carbohydrate.


Inhibition of fungal growth and sporulation by volatile metabolites from bacteria.


Further observations on the mode of action of the alpha toxin of Staphylococcus aureus "Wood-46".


Neural pathways from the neocortex to the hypothalamus.


Feedback effects of sex hormones on hypothalamic unit activity.


On the innervation of exocrine glands.

On the innervation of exocrine glands.


An electron microscope study of the commissural connexions of the primate motor complex.


An electron microscope study of afferent fibre connexions to the monkey thalamus from motor cortex and basal ganglia.


The effects of optic tract section on the lateral geniculate nucleus.


Axonal degeneration after intrinsic lesions of the visual cortex.


The marmoset as a model for teratological research.


Bacteriophage types of mycobacteria.

Bacteriophage types of mycobacteria.


Placenta of marmosets.

Placenta of marmosets.


Limb reduction anomalies induced in the marmoset by thalidomide.


Membrane attachment of the replication origins of a multifork (dichotomous) chromosome in Bacillus subtilis.


Ruptured mycotic pericallosal aneurysm with meningitis due to Neisseria meningitidis infection. Case report.


Descent of mammalian alpha globin chain sequences investigated by the maximum parsimony method.


The long-term management of migraine with clonidine.


A double-blind controlled trial of disodium cromoglycate in seasonal allergic rhinitis.


Peripheral tissue distribution, brain distribution, metabolism, placental transfer, & fetal distribution of mescaline- 14 C in monkeys.


The course of P. falciparum (Vietnam Oak Knoll strain) in Aotus trivigatus.


Possible antigen variation in Plasmodium knowlesi on mosquito passage.


Frenkelia glareoli: a record from Devon.


A, B, O and Rhesus blood grouping of insect blood meals of human origin.


A microsporidian parasite of Simulium larvae.


Quantitative recovery of floatable helminth eggs from 1 g. of ruminant faeces for counting followed by hatching for identification.


Filter paper collection of blood for use in a screening and diagnostic test for scrub typhus using the IFAT.


Trypanosoma cyclops n. sp.: a pigmented trypanosome from the Malaysian primates Macaca nemestrina and M. ira.


Sporozoite transmission of falciparum malaria (Vietnam, Smith strain) from monkey to monkey.


The effects of a synthetic thyrotrophin releasing hormone (TRH) in normal and endocrinopathic subjects.


Monkey therapists.

Monkey therapists.


Tissue-air ratio, backscatter factor and definition of field size.


Further studies of the chemical composition of the lipopolysaccharide of Pseudomonas aeruginosa. 1. Qualitative and quantitative analytical results for the lipopolysaccharide from acetone-dried cells of Pseudomonas aeruginosa (N.C.T.C. 1999) are presented and possible contamination of the material with nucleic acid was further examined. 2. Additional sugars detected (only in large-scale hydrolysates) were mannose and arabinose; traces of spermidine and putrescine were also found. 3. The heptose component is l-glycero-d-mannoheptose. 4. The thiobarbituric acid-positive component is a 3-deoxy-2-octulonic acid, of which only 35-40% links lipid A to the polysaccharide. This linkage is not broken by hydrolysis with acetic acid up to 0.08m. 5. Liberation of lipid A required hydrolysis with 0.1m-hydrochloric acid, which substantially degraded the polysaccharide moiety. 6. Fractions obtained from the degraded polysaccharide by high-voltage electrophoresis were examined; in these, the alanine/galactosamine molar ratio is approx. 1. 7. Hydrazinolysis of whole lipopolysaccharide showed that at least 40% of the alanine is in amide linkage, possibly with galactosamine. 8. Lipid A, solubilized by alkaline methanolysis was fractionated; most of the phosphorus of the higher-molecular-weight fractions was released as P(i) by a phosphomonoesterase. 9. Hydrazinolysis of lipid A destroyed approx. 80% of the glucosamine, and glycosidically linked glucosamine oligosaccharides could not be isolated.


A mobile caesium safe for afterloading intra-uterine applicators.


The branchpoint of pyocyanine biosynthesis.


Characterization of mycoplasmas isolated from the bush baby (Galago crassicaudatus).


The effect of osmotic shocking upon Bacillus subtilis transformation.


Exogenous carbon and nitrogen requirements for conidial germination by Aspergillus flavus.


Drug-induced histological changes and its consequences on the permeability of the small intestinal mucosa. I. EDTA, tetracycline, and sodium laurylsulfate.


Synaptic patterns in the superficial layers of the superior colliculus of the monkey, Macaca mulatta.


Occurrence of Australia antigen in chronic hepatitis in Italy.


Response to orally administered synthetic thyrotropin-releasing hormone in man.


Steroid levels in the human fetus: cortisol and cortisone.


Idiopathic galactorrhea and mild hypogonadism in a young adult male.


The effect of synthetic corticosteroids on ovarian function in the baboon.


Methods for the assessment of microbial populations recovered from enclosed aerosols.


Some properties of the immunogens (protective antigens) of a single variant of Trypanosoma brucei brucei.


An evaluation of taxonomic criteria in streptomycetes on the basis of deoxyribonucleic acid homology.


Rapid assays for the detection and determination of sparse populations of bacteria and bacteriophage T7 with radioactively labelled homologous antibodies.


Physical, chemical and morphological studies of spore coat of Bacillus subtilis.


Enhancement and prolongation of Babesia microti infections in mice infected with oncogenic viruses.


Antimicrobial agents from higher plants. IV. Zanthoxylum elephantiasis. Isolation and identification of Canthin-6-one.


An assessment of work simplified procedures for the microbiological assay of serum vitamin B12 and serum folate.


Measurement and control of dose equivalent to patients undergoing whole-body neutron irradiation for in vivo activation analysis.


The determination of   1  C-globulin (C' 3  component of complement) by immunodiffusion in various clinical states of bronchial asthma.


L-dopa, behavioral activation and psychopathology.


Pathophysiology of staphylococcal enterotoxin, type B, (SEB) toxemia after intravenous administration to monkeys.


Cerebral evolution and emotional processes: new findings on the striatal complex.


Cytogeometric integration in the ciliate cortex.


Epidemiology of pseudomonas aeruginosa in a burn hospital: evaluation of serological, bacteriophage, and pyocin typing methods. In a retrospective study 36 cultures of Pseudomonas aeruginosa, isolated from patients with fatal Pseudomonas burn wound sepsis and from burned patients with nonfatal P. aeruginosa infections, were used to evaluate the consistency and reliability of serological, phage, and pyocin typing as epidemiological tools. Frequency distributions of positive reactions were analyzed by a computer in a 3-way chi-square test, and a high degree of consistency was demonstrated for each method. From these data, 75% of the cultures were differentiated by serological, 90% by phage, and 100% by pyocin typing. There was no significant difference among organisms isolated from fatal cases of burn wound sepsis and organisms from patients with nonfatal infections (chi(2) = 0.3418; P = 0.9870). The combined typing system was a sensitive and reliable epidemiological tool for intraspecific differentiation of P. aeruginosa.


Epidemiology of Pseudomonas aeruginosa in a burns hospital: surveillance by a combined typing system. For 3 months, 259 cultures of Pseudomonas aeruginosa isolated from nonpatient environmental sources and 262 cultures from 16 infected patients in the Intensive Care Unit (ICU) of Shriners Burns Hospital were typed by a combined system with a high degree of reliability. Sinks were major sources of environmental contamination. Serotypes 1 and 2 were the predominant types found in patients, and they were most prevalent among typable strains from sinks. Strain designations were made on the basis of similarities in data from serological and phage typing. All nontypable strains were typed by pyocin production. Two infected patients carried different strains of P. aeruginosa that remained the same type for 45 days, even though their beds in ICU were approximately 6 feet apart. Cross-contamination from patient to patient and spread of infection by nursing personnel were eliminated as major modes of transmission because nasopharyngeal swabs, hair samples, and hands of nursing staff were consistently negative. Splashing of water from contaminated sinks to fomites was suggested as a possible mode of transfer for this infectious agent.


Utilization of collagenous by-products from the meat packing industry: production of single-cell protein by the continuous cultivation of Bacillus megaterium. The conditions for continuous cultivation of Bacillus megaterium on a collagen-derived substrate (SP-100) were determined. The optimum conditions of temperature, pH, and dilution rate were 34 C, pH 7.0, and 0.25/hr, respectively. Increasing the substrate concentration in plain tap water resulted in proportional increases in the productivity of cell mass from 0.6 g per liter per hr at 1% substrate to 1.8 g per liter per hr at 10% substrate; however, the protein content of the biomass decreased from 60 to 36%, and the protein yield decreased from 91 to 50% at substrate concentrations of 1 and 10%, respectively. These effects (decreases) were reversed up to 7.5% substrate by mineral supplementation of the medium. The productivity of biomass increased from 0.6 to 1.9 per liter per hr; the protein content of the biomass, from 43 to 54%; and the protein yield, from 60 to 93%, respectively, as the substrate concentration (with mineral supplementation of the medium) was increased from 1 to 7.5%. Spent medium could be refortified and recycled as often as five times. The amino acids in the substrate protein appeared to be utilized for growth and metabolism more or less uniformly. Analysis of the B. megaterium biomass indicated considerable enrichment of the essential amino acids and reduction of proline, glycine, and hydroxyproline as compared to the collagen-derived substrate. The Protein Efficiency Ratios obtained on the collagen-derived substrate (SP-100) and on the B. megaterium biomass, expressed as percentages of the casein reference protein, were 14 and 74%, respectively. Thus, considerable improvement in nutritional value was effected by bacterial conversion of the collagen-derived substrate into single-cell protein.


Cortical potentials evoked by tooth pulp stimulation in rhesus monkeys.


Improvement of microbial assays of vitamins. A method for the improvement of microbial assays of vitamins, which involves the addition of a surfactant to the incubated test, was developed. This surfactant tends to eliminate bacterial clumping, giving a uniform suspension of single cells, thereby making the turbidity readings less erratic and the actual assay standard curves more closely related to the desired theoretical curve.


Filamentous bacteria isolated from human root surface caries.


Epidemiological and biochemical studies of necrotizing ulcerative gingivitis and noma (cancrum oris) in Nigerian children.


The effect of flow rate on the C1 - , Na +  and K +  concentrations in parotid saliva of the baboon.


Proteolytic components of alkaline proteases of Bacillus strains. Zymograms and electrophoretic isolation.


Conversion of L-sorbose to 5-keto-D-fructose by Pseudomonads.


Studies on the biochemical chacteristics of malnutrition in Pakistani infants and children.


Interrelationship between the growth-promoting effect of fish solubles and the gut flora of the chick.


Experimental protein-energy malnutrition in baby baboons. Attempts to reproduce the pathological features of kwashiorkor as seen in Uganda.


Energetic efficiency of the utilization of acetic acid and glycerol by fattening sheep.


Experimental infection of turkey poults with Arizona serotype 7; 1, 7, 8.


Development of schizonts directly from the blood piroplasms of the Australian Theileria mutans.


Interaction of hormones and blood proteins. The binding power of rat plasma proteins to thyroxine.


Glybenclamide enhancement of polyuria in patients with pituitary diabetes insipidus (preliminary report).


Electric charge of protein molecules: thyroxine binding globulin.


Interlocking patterns on primate lens fibers.


Conversion of DDT and its metabolites to dichlorobenzophenones for analysis in the presence of polychlorinated biphenyls.


Identification of polychlorobiphenyls by high resolution proton magnetic resonance.


Lymphopoiesis in the rat. II. The effect of thymectomy.


Incorporation and intraparticulate hydrolysis of 131 I-albumin by liver and kidney of an amphibian (Bufo arenarum).


The synaptic organization of the cortical projection to the pulvinar of the squirrel monkey.


Regulation of food intake during intermittent and continuous cross circulation in monkeys (Macaca mulatta).


The role of climbing fibers in the formation of Purkinje cell dendrites.


Failure to find homology in rat, cat, and monkey for functions of a subcortical structure in avoidance conditioning.


Anthrax infection in bone meal from various countries of origin. Using animal inoculation, three out of six Lebanese and three out of nine Argentinian and two out of two Pakistan separate commercial consignments of bone meal imported during 1970 were found to be infected with anthrax.


IgG, IgA and IgM responses in acute rubella determined by the immunofluorescent technique. The indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in twelve adult cases of acute uncomplicated rubella. IgG, IgA and IgM antibodies increased virtually simultaneously. IgG antibody persisted throughout the period of study but showed a slight tendency to fall in titre after 7 months. IgM antibody was detected in nine cases. In these patients it was present in high titre 5-15 days after the rash but was not detected after 20 days. IgA antibody was detected in all cases. It was present in high titre 5-20 days after the rash but was no longer detectable after 29 days except in one patient who had a very low titre at 78 days. The presence of specific IgA and IgM indicates recent rubella in uncomplicated cases, and if the immunofluorescent method is used both types of antibody should be sought.


The temperature sensitivity of the type I slowly adapting mechanoreceptors in cats and monkeys. 1. The sensitivity of Type I slowly adapting mechanoreceptors in cat and monkey skin to temperature and changes in temperature was investigated.2. Multiple receptors innervated by a single axon appeared to be more frequent in the monkey than in the cat skin.3. The responses of these receptors to thermal stimulation at static skin temperatures from 27 to 40 degrees C were similar in cats and monkeys. At 43 degrees C the monkey receptors showed a higher steady-state activity than the cat receptors.4. A maximum steady-state frequency of 5.5 impulses/sec occurred in both the cat and monkey receptors at a static skin temperature of 37 degrees C.5. The maximum dynamic response to cooling occurred at a skin temperature of 40 degrees C. The response was near its maximum at 2 degrees C cooling and increased but little with further increases in the intensity of cooling.6. Dynamic responses to cooling disappeared after the skin had been heated to 51 degrees C for 35 sec and to mechanical stimulation after heating to 53 degrees C for 35 sec. Excitation by either mechanical or thermal stimulation did not reappear within 1-2 hr.7. The response characteristics of the Type I slowly adapting mechanoreceptors to temperature and temperature changes differ from those of specific cold receptors.


Diphtheria infection in North West Canada, 1969, 1970 and 1971. In three years, Corynebacterium diphtheriae was isolated from 1238 people, consisting of 820 North American Indians or Metis, 318 people of Caucasian origin, 97 Eskimos and 3 Asiatic Indians. Diphtheria infection of the throat, nose, ears and skin was common in the North American Indian and Metis people, but rarely caused severe symptoms. The infection occurred less often in white people but was more serious; of 27 cases of toxic respiratory diphtheria, 25 were white people. The public health significance of the endemic infection of the North American Indian and Metis people is discussed.


Intravenous feeding.

Intravenous feeding.


Case records of the Massacusetts General Hospital. Weekly clinicopathological exercises. Case 43-1972.


Metabolism of third complement component (C3) in nephritis. Involvement of the classic and alternate (properdin) pathways for complement activation.


Effect of Althesin on carotid blood flow and intracranial pressure in the anaesthetized baboon: a preliminary communication.


Survey on mastitis caused by environmental bacteria.


Immunoglobulin class in relation to neutralisation of transmissible gastro-enteritis virus.


The possible mode of action of prostaglandins. I. Interruption of decidual reaction by PGF 2a and its prevention by using prolactin or progesterone.


Early development of the embryo in non-human primates and man.


Culture of human embryos in vitro.

Culture of human embryos in vitro.


Hormonal control of the menstrual cycle and ovulation in the rhesus monkey.


Positive feedback of ovarian steroids in rats and monkeys.


Steroid hormones in non-human primates during pregnancy.


Neuroendocrine regulation of sexual cycles and ovulation in non-human primates.


Gametogenesis.

Gametogenesis.


Steroid hormones in pregnancy: the baboon as a model for studies on oestrogen synthesis.


Chorionic gonadotrophin in non-human primates.


Chorionic gonadotrophin, corpus luteum function and embryo implantation in the rhesus monkey.


The pathology of the rhesus monkey placenta.


Asphyxia in the primate foetus.

Asphyxia in the primate foetus.


Abnormalities of intrauterine development in non-human primates.


Effects on macaque embryos of drugs reported or suspected to be teratogenic to humans.


The pattern and abnormality rate of monkeys of the Sukhumi colony.


Recent research on the mode of action of intra-uterine devices in primates.


Investigations of intrauterine devices in Macaca mulatta monkeys.


The metabolism and effects of contraceptive steroids in primates.


Differences in drug metabolism between common laboratory animals and primates.


Aspects of spermatogenesis.

Aspects of spermatogenesis.


Comparative features of the reproductive biology of hamadryas baboons (Papio hamadryas), grivet monkeys (Cercopithecus aethiops) and rhesus monkeys (Macaca mulatta).


Fertility regulation in non-human primates by non-steroidal compounds.


Reproduction of Japanese monkeys.

Reproduction of Japanese monkeys.


The breeding of hamadryas baboons at the Sukhumi Primate Centre.


Ovum maturation, gamete transport, capacitation and fertilization in the monkey.


Advantages of laboratory-bred monkeys over wild-caught animals.


The use of hamadryas baboons for the study of the immunologic aspects of human reproduction.


Immunology of pregnancy.

Immunology of pregnancy.


Some pathological aspects of ovum maturation and gamete transport in mammals and man.


Implantation.

Implantation.


Choice of animal model for study of ovum implantation.


Transcription and processing of ribonucleic acid in Rhynchosciara salivary glands. I. Rapidly labeled ribonucleic acid.


On the origin of bioconvective fluid instabilities in Tetrahymena culture systems.


Calcium binding proteins in the duodenal mucosa of the chick, rat, pig, and human.


Virus-induced alterations of lymphoid tissues. II. Lymphocyte receptors for Newcastle disease virus.


Thyroxine binding proteins, free thyroxine and thyroxine turnover interrelationships during acute infectious illness in man.


Effect of control of hyperglycemia on plasma insulin responses to various stimuli in newly diagnosed ketosis-prone diabetic patients.


Avoiding the pitfalls of long-term therapeutic trials: lessons learned from the UGDP study.


A quantitative, single-radial-diffusion test for immunological studies with influenza virus.


Mechanisms of cell and tissue injury induced by group A streptococci: relation to poststreptococcal sequelae.


Role of drug metabolism in drug research and development: basic considerations.


The effect of augmented feedback on cardiac conditioning in the Rhesus monkey.


Gas chromatographic separation of the aglycone metabolites of carbaryl.


Fate of naphthyl-1- 14 C carbaryl in laying chickens.


Neutron production from electron accelerators used for medical purposes.


Selection and preliminary characterization of temperature-sensitive mutants of type 5 adenovirus. Eight temperature-sensitive (ts) mutants that replicate normally at 32 C but poorly, if at all, at 39.5 C have been isolated from mutagenized stocks of a wild-type strain of type 5 adenovirus. Three mutagens were employed: nitrous acid, hydroxylamine, and nitrosoguanidine. Ts mutants were isolated from mutagenized viral stocks with frequencies between 0.01 and 0.1%. All eight mutants had reversion frequencies of 10(-5) or less. Complementation experiments in doubly infected cultures at the nonpermissive temperature separated the mutants into three nonoverlapping complementation groups. Complementation yields ranged from a 2.3- to a 3,000-fold increase over the sums of the yields from the two singly infected controls. Genetic recombination was also demonstrated; approximate recombination frequencies ranged from 0.1 to 15%. Preliminary biochemical and immunological characterization of the mutants indicated that: (i) the single mutant in complementation group I did not replicate its deoxyribonucleic acid (DNA) or synthesize late proteins at the nonpermissive temperature but did inhibit host DNA synthesis to 25% of an uninfected control; (ii) the four group II mutants replicated viral DNA, shut off host DNA synthesis, synthesized penton base and fiber, but did not synthesize immunologically detectable hexon; the three mutants in complementation group III synthesized viral DNA, shut off host DNA synthesis, and made immunologically reactive capsid proteins (hexon, penton base, and fiber).


Comparative immunofluorescent studies on 4 Babesia species of cattle.


A rapid technique for the detection of theilerial parasites in the salivary glands of the tick Rhipicephalus appendiculatus.


The duration of emission of infective particles of Theileria parva by infected ticks fed artificially.


Salmonella paratyphi B infection in dairy cows. II. Investigation of an active carrier.


The structure and antigenic analysis of amorphous inclusion bodies induced by potato virus X.


Arrest of host DNA synthesis in Bacillus subtilis infected with phage phi e.


Alfalfa mosaic virus hybrids constructed by exchanging nucleoprotein components.


Studies on the early antigens induced by vaccinia virus.


Biological chromatography. The laws of colour and design in nature.


Determination, regulation, and positional information in insect development.


Multi-compartmental analysis in steady state as a stochastic process.


A model proposed for the process of evolution with special reference to plants.


Agglutination of erythrocytes freshly washed with saline solution. Four saline-autoagglutinating sera.


An analysis of "balance in nature" as an ecological concept.


Investigation of elliptocytosis and the Rh blood group locus.


Effects of alterations in calcium concentrations on secretion and protein synthesis in cat submandibular salivary gland.


Evaluation of a hemagglutination inhibition method for the detection of HAA.


Demonstration of a sex difference in recombination fraction in the loose linkage, Rh and PGM.


Thyroxine-binding prealbumin. Conformation in urea and guanidine.


C-phycocyanin from Phormidium luridum. Isolation of subunits.


Studies on the structure of an ornithine-containing lipid from Rhodospirillum rubrum.


Association of reovirus mRNA with viral proteins: a possible mechanism for linking the genome segments.


Cyanide metabolism in higher plants. V. The formation of asparagine from  -cyanoalanine.


The rise time of photoreduction, difference spectrum, and oxidation-reduction potential of P430.


Comparison of serological tests for detection of Arizona infection in adult turkeys.


Sex and age differences in response to infant squirrel monkeys.


Patterns of puffing activity in the salivary gland chromosomes of Drosophila. VI. Induction by ecdysone in salivary glands of D. melanogaster cultured in vitro.


Patterns of puffing activity in the salivary gland chromosomes of Drosophila. VII. Homology of puffing patterns on chromosome arm 3L in D. melanogaster and D. yakuba, with notes on puffing in D. teissieri.


Nonatheromatous ischemic heart disease following withdrawal from chronic industrial nitroglycerin exposure.


Effects of alpha-MSH on melanogenesis and tyrosinase of B-16 melanoma.


Enzymatic synthesis of thyrotropin releasing hormone (TRH) by hypothalamic "TRH synthetase".


Testosterone metabolism in target tissues: effects of testosterone and dihydrotestosterone injection and hypothalamic implantation on serum LH in ovariectomized rats.


Cyclamate still to the fore.

Cyclamate still to the fore.


Antigenic changes in mouse epidermis at various stages of neoplastic transformation.


The genetical architecture of sternopleural chaeta number in Drosophila melanogaster.


Scrapie: effect of Dh gene on incubation period of extraneurally injected agent.


An IgA-like immunoglobulin in the fowl.

An IgA-like immunoglobulin in the fowl.


Chemical and immunological characterization of the electrophoretic components of the Fc fragment of human immunoglobulin G.


Immunological comparison of isolated human native 7S IgM and 19S IgM before and after reduction.


Gas-liquid chromatographic determination of nitroglycerine in pharmaceutical preparations.