Infant monkeys--a model for crib death.

Infant monkeys--a model for crib death.


Clinical videodensitometry.

Clinical videodensitometry.


Functional morphology of the setal protractors in Pheretima posthuma (Vaillant).


Fatty acid composition and physiological properties of some filamentous blue-green algae.


Ultrastructure of the ventricular walls. Three-dimensional study of regional specialization.


Scanning electron microscopy in otorhinolaryngologic research, 1970.


Long-term plasmapheresis: effects on specific plasma proteins.


Coronary circulation systemic resistance and capacitance blood vessels of dogs as affected by BAY a 1040.


The clinical effect of 4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine (BAY a 1040) on angina pectoris evaluated by sequential analysis.


Vaccination with lyophilized turkey herpesvirus (HVT): minimum infective and protective doses.


Antibody against purified human hexosaminidase B cross-reacting with human hexosaminidase A.


The origin of the genetic material in the abnormally long human hemoglobin   and   chains.


Purification of glycogen synthetase-D from human polymorphomuclear leukocytes.


Pyruvate kinase of bacillus subtilis.

Pyruvate kinase of bacillus subtilis.


Some regulatory properties of phospho-2-keto-3-deoxyheptonate aldolase from the blue-green alga Anacystis nidulans.


Rapidly labelled ribonucleic acid in chicken embryos. Evidence for heterogeneous ribonucleoprotein particles.


A general method of increasing the sensitivity of immune diffusion. Its application to CEA.


Immunochemical characterization of the "pre- " band in lipoprotein electrophoresis.


The binding of iron to transferrin and to other serum components at different degrees of saturation with iron.


Water intake: influence on development of rat saline hypertension.


Indomethacin and prostaglandins.

Indomethacin and prostaglandins.


Relationship between afferent input and motor output in sensorimotor cortex of the monkey.


An "anti-secretor"-reagent for the direct estimation of the Se-status by precipitation.


Rudimentary pigmentgenesis in the pineal organ of the chick embryo.


Serology and genetics of a new blood factor: hr B .


Quantitation of cutaneous blood circulation in the rhesus monkey (Macaca mulatta).


Alexander Wiener and the Landsteiner tradition.


Purification and characterisation of the in vitro colony forming cell in monkey hemopoietic tissue.


Review of Rh serology. Eight new antigens in nine years.


Protein synthesis in polymorphonuclear leucocytes in the presence of diphtheria toxin.


Studies of human erythrocytes by endless belt electrophoresis. I. A comparison of electrophoretic mobility with serologic reactivity.


Blood transfusion--1914 model.

Blood transfusion--1914 model.


Effects of prostaglandin E 1  on experimental cerebral vasospasm.


Some recollections of the meningococcal diseases. The first Harry F. Dowling lecture.


pH and titratable acidity of amino acid mixtures used in hyperalimentation.


The enteroviruses.

The enteroviruses.


Arboviruses.

Arboviruses.


Postoperative hemorrhage and abscess formation following biliary tract surgery: a search for causative relations and means of prevention.


Metabolism of procainamide in rhesus monkey and man.


Antiepithelial antibodies in prostatic cancer.


Consequences of malnutrition.

Consequences of malnutrition.


Treatment of chronic drug-resistant pulmonary tuberculosis with rifampin and ethambutol. Twenty patients with chronic pulmonary tuberculosis completed eight months of rifampin-ethambutol treatment. Half the patients received daily 600 mg. rifampin and 25 mg./kg. ethambutol for the first two months and subsequently 15 mg./kg. The others received the same dosage of ethambutol and 450 mg. rifampin daily. The average time of sputum conversion was seven weeks and 11 weeks in the two groups respectively. The patients tolerated these drug regimens well.Rifampin blood levels and urinary excretion were studied monthly during the therapy. They indicated that after a short period of treatment the elimination of this drug became faster owing to increased excretion of rifampin, and particularly of its desacetyl metabolite, in the bile. Liver damage resulted in a slower excretion rate. Rifampin should be taken on an empty stomach because simultaneous food intake reduces the peak blood concentration.


Intrauterine infection and cord immunoglobulin M. I. Analysis of methods of assay and levels of immunoglobulin M in normal newborns. An analysis of methods of assay and levels of immunoglobulin M in the cord serum of 100 normal newborn infants is reported. The geometric mean level of cord IgM was found to be 9.8 mg.%. The 95th percentile value was 19.6 mg.%. IgM levels on day one were not significantly different from cord levels, while by day five a significant increase had occurred (geometric mean 13.6 mg.%). IgA was present in only 3/100 cord sera (in levels above 6.0 mg.%). Any increment of day five IgM over cord levels greater than threefold is thought to be abnormal and this parameter will be further evaluated as an index of neonatal sepsis. Use of locally produced reagents in the IgM assay was found to be more accurate and inexpensive than the commercially available reagents.


Patients and the future.

Patients and the future.


Rh-D isoimmunization in a triplet pregnancy.


Response to disodium cromoglycate in children with chronic asthma. Twenty-three children with chronic severe perennial asthma received randomly-allocated disodium cromoglycate or placebo four times a day for 12 weeks, and the alternative regimen for the subsequent 12 weeks. More than half the patients improved while on DSCG according to clinical assessment. There was a significant increase in the mean FEV(0.75 second) during the drug period, largely owing to dramatic improvement in nine patients. No reduction in the mean decrease of FEV after exercise was demonstrated. Response, when it occurred, was evident within four weeks. The effect of the medication was consistent in individual patients throughout the 12-week period. No evidence of toxicity was discovered during the period of study.


Freedom and authority in the practice of medicine.


A clinical and metabolic study of an intravenous feeding technique using peripheral veins as the initial infusion site. Two commercially available, high-caloric intravenous solutions were given as the sole source of calories to 23 children (aged three weeks to 17 years), all gravely ill and unable to ingest untrients, for one to 12 weeks. All but one survived, gained weight, remained in positive nitrogen balance and resumed taking adequate diets by mouth.The patients utilized sugar, amino acids and fats efficiently without abnormalities of kidney and liver function. Septicemia developed in six of 15 patients receiving solution by central venous catheter. Those receiving infusion by peripheral vein only, eight of 23, remained infection-free.The procedure is safe if serum electrolytes are constantly and meticulously monitored and is a useful adjunct to the treatment of children unable to eat.


Basic principles of drug interaction.

Basic principles of drug interaction.


New procedure for purifying and crystallizing alkaline phosphatase from human intestinal mucosa.


Direct-contact (membraneless) hemoperfusion through oils.


Preparation of immune sera against human and animal IgG globulins.


Brucella abortus recovery from milk samples.


Genetic polymorphism of glycerol-3-phosphate dehydrogenase (E.C.: 1.1.1.8). II. Transspecific variability of G-3-PD subunit A in primates. Formal genetics and population genetics.


The genetic polymorphism of the thyroxine-binding globulin (TBG).


A sensitive isotope modification of the mixed haemadsorption test applicable to the study of prozone effects.


Measurement of antibody-producing capacity in man. V. Immunoglobulin classes of antibodies to flagellin.


Antibody response of goldfish to a protein immunogen and to haptenic determinants.


The effects of hypothyroidism on the ears of cats and squirrel monkeys: a pilot study.


Cytochemical localization of tyrosinase activity in pigmented epithelial cells of Rana pipiens and Xenopus laevis larvae.


The etiology and prevention of dental caries. Report of a WHO scientific group.


Effect of changes in osmolarity on sodium transport across isolated toad bladder.


Adsorption of a ribonucleic acid bacteriophage of Pseudomonas aeruginosa.


A representation of the visual field in the inferior nucleus of the pulvinar in the owl monkey (Aotus trivirgatus).


Amino acid content of epileptogenic human brain: focal versus surrounding regions.


Light and electron microscopic study of crossed ascending pathways in the anterolateral funiculus in monkey.


Controlled extension of oral antidiabetic therapy on former insulin dependent diabetics by means of the combined i.v. glibenclamide-glucose-response-test.


Central projections of the spiral ganglion of the squirrel monkey.


A radioassay for serum folate: use of a two-phase sequential-incubation, ligand-binding system.


Von Recklinghausen's disease in children.


Photocoagulation for diabetic retinopathy.


Neurofibromatosis with oral manifestations: report of a case.


Some observations on the use of parenteral alimentation.


Contemporary tuberculin testing.

Contemporary tuberculin testing.


Fatal hemorrhage as a complication of neurofibromatosis.


Development of antigen during the course of serum hepatitis. Measurements by electron microscopy and by immunodiffusion.


Individual morphological variations seen in Australia antigen positive sera.


Purification of large quantities of Australia antigen by density gradient centrifugation.


Epidemic hepatitis-associated antigen (milan antigen). Study on normal population and sporadic acute viral hepatitis.


Epidemiology of viral hepatitis and its long-term sequelae in Poland.


Relationship of Milan antigen to abnormal serum lipoprotein.


Epidemiologic aspects of viral hepatitis in Greece.


Epidemiological study of type B hepatitis in communities.


Australia antigen and the human fetus.

Australia antigen and the human fetus.


Hepatitis associated antigen carriers among blood donors in Greece.


Australia antigen and serum hepatitis. A prospective study of the frequency of serum hepatitis after transfusion of Au-SH-antigen positive blood units.


Australia antigen and extracorporeal circulation in 819 cases.


Fecal SH-antigen in acute hepatitis.

Fecal SH-antigen in acute hepatitis.


Inapparent infections in the course of an epidemic of Australia-SH-antigen positive hepatitis.


Frequency of Australia antigen in blood donors in Singapore.


Australia antigen in Africans. An anatomic, clinical, and immunologic study.


Immune response in patients who received blood containing serum hepatitis antigen. Studies with the passive hemagglutination technique.


Primary tuberculous otomastoiditis.

Primary tuberculous otomastoiditis.


Divalent cations in transfer ribonucleic acid and aminoacyl transfer ribonucleic acid synthetase function and structure.


Radioimmunoassay of rat prolactin comparing prolactin obtained from anterior pituitary organ culture with that distributed by the National Institute of Arthritis and Metabolic Diseases.


Polyphenol oxidases.

Polyphenol oxidases.


Metabolic DNA in ciliated protozoa, salivary gland chromosomes, and mammalian cells.


Congenital ocular defects in cattle, horses, cats, and dogs.


Serum anti-immunoglobulins in psoriatic arthritis as compared with rheumatoid arthritis.


L-Ribulose 5-phosphate 4-epimerase from Aerobacter aerogenes. Evidence for a role of divalent metal ions in the epimerization reaction.


The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.


Metabolism of trehalose in Euglena gracilis. I. Partial purification and some properties of trehalose phosphorylase.


A study of retrograde cell degeneration in the lateral mammillary nucleus of the cat, with special reference to the role of axonal branching in the preservation of the cell.


Neuronal and synaptic organization of the normal dorsal lateral geniculate nucleus of the squirrel monkey, Saimiri sciureus.


Terminal degeneration and glial reactions in the lateral geniculate nucleus of the squirrel monkey after eye removal.


Nigrostriatal and nigrothalamic fibers in the rhesus monkey.


Temperature dependence of vasopressin action on the toad bladder. Toad bladders were challenged with vasopressin at one temperature, fixed on the mucosa with 1% glutaraldehyde, and then subjected to an osmotic gradient at another temperature. Thus, the temperature dependence of vasopressin action on membrane permeability was distinguished from the temperature dependence of osmotic water flux. As the temperature was raised from 20 degrees to 38 degrees C, there was a substantial increase in the velocity of vasopressin action, but osmotic flux was hardly affected. In this range of temperature the apparent energy of activation for net water movement across the bladder amounted to only 1.2 kcal/mole, a value well below the activation energy for bulk water viscosity. It is suggested that osmotic water flux takes place through narrow, nonpolar channels in the membrane. When the temperature was raised from 4 degrees to 20 degrees C, both vasopressin action as well as osmotic water flux were markedly enhanced. Activation energies for net water movement were now 8.5 kcal/mole (4 degrees -9 degrees C) and 4.1 kcal/mole (9 degrees -20 degrees C), indicating that the components of the aqueous channel undergo conformational changes as the temperature is lowered from 20 degrees C. At 43 degrees C bladder reactivity to vasopressin was lost, and irreversible changes in selective permeability were observed. The apparent energy of activation for net water movement across the denatured membrane was 6.6 kcal/mole. Approximately 1 microosmol of NaCl was exchanged for 1 microl of H(2)O across the denatured membrane.


Microspectrophotometry of arthropod visual screening pigments. Absorption spectra of visual screening pigments obtained in vitro with a microspectrophotometer using frozen sections are given for the insects Musca domestica, Phormia regina, Libellula luctuosa, Apis mellifera (worker honeybee only), Drosophila melanogaster (wild type only) and the arachnids Lycosa baltimoriana and Lycosa miami. The spectral range covered is 260-700 nm for Lycosa and Drosophila and 310-700 nm for the remainder of the arthropods. A complete description of the instrumentation is given. For the flies, Phormia and Musca, light absorption by the yellow and red pigments is high from 310 to about 610 nm. This implies that for these insects there should be no wavelength shift in electroretinogram (ERG) results due to light leakage among neighboring ommatidia for this wavelength range. The same comment applies to Calliphora erythrocephala, which is known to have similar screening pigments. For some of the insects studied a close correspondence is noted between screening pigment absorption spectra and spectral sensitivity curves for individual photoreceptors, available in the literature. In some cases the screening pigment absorption spectra can be related to chemical extraction results, with the general observation that some of the in vitro absorption peaks are shifted to the red. The Lycosa, Apis, and Libellula dark red pigments absorb strongly over a wide spectral range and therefore prevent chemical identification.


Studies in pregnant rats, rabbits and monkeys with lithium carbonate.


Current status of tests of carbaryl for reproductive and teratogenic effect.


Folate antagonists covalently linked to carbohydrates: synthesis, properties, and use in the purification of dihydrofolate reductases.


Divalent cation binding to chloroplast membranes and its relationship to reversal of quaternary ammonium salt uncoupling of photophosphorylation.


Isolation and characterization of a tryptophan-resistant mutant of echovirus type 8.


The effect of proflavine on rubella virus replication in baby hamster kidney (BHK-21) cells.


Presence of virus-specific RNA in hamster cells transformed by simian adenovirus SA7.


The effect of penicillin on competence in Bacillus subtilis cultures growing in chemostat at different doubling times.


Peters' anomaly and total posterior coloboma of retinal pigment epithelium and choroid.


Preretinal glial nodules in persistence and hyperplasia of primary vitreous.


Pheochromocytoma, medullary thyroid carcinoma, multiple mucosal neuroma. A variant of the syndrome.


Cerebro-hepato-renal (Zellweger's) syndrome. Ocular involvement.


Interaction between sodium dodecyl sulfate and ferricytochrome c.


Phospholipases and phospholipid turnover in Escherichia coli spheroplasts.


Environmentally produced alterations of the tetrahymanol: phospholipid ratio in Tetrahymena pyriformis membranes.


Phosphatidyl choline species in Euglena gracilis.


Galactosamine polymer isolated from the cell wall of Neisseria sicca.


Mechanism of biological action of a new benzindazole compound.


New analogues of aspergillic acid derived from methionine.


Autistic psychotic and brain injured adolescents.


The effects of parathyroid hormone on the calcium fractions of serum of rats.


Influence of thyrotropin-releasing-factor (TRH) on TSH-subfractions in human plasma separated by electrofocusing electophoresis.


Aspects of synaptic and laminar organization of the mammalian lateral geniculate body.


Nonretinal influences on the lateral geniculate nucleus.


Visual cortex: structure and connections.


Spatial properties of neurons in striate cortex of unanesthetized macaque monkey.


A dose equivalence study of glybenclamide (daonil)--a new hypoglycaemic agent.


Evidence for a temporal incompatibility between DNA replication and division during the cell cycle of Tetrahymena. The mechanism of coordination between DNA replication and cell division was studied in Tetrahymena pyriformis GL-C by manipulation of the timing of these events with heat shocks and inhibition of DNA synthesis. Preliminary experiments showed that the inhibitor combination methotrexate and uridine (M + U) was an effective inhibitor of DNA synthesis. Inhibition of the progression of DNA synthesis with M + U in exponentially growing cells, in which one S period usually occurs between two successive divisions, or in heat-shocked cells, when successive S periods are known to occur between divisions, resulted in the complete suppression of the following division. In further experiments in which the division activities were reassociated with the DNA synthetic cycle by premature termination of the heat-shock treatment, it was shown that (a) the completion of one S period during the treatment was sufficient for cell division, (b) the beginning of division events suppressed the initiation of further S periods, and (c) if further S periods were initiated while the heat-shock treatment was continued, division preparations could not begin until the necessary portion of the S period was completed, even though DNA had previously been duplicated. It was concluded that a temporal incompatibility exists between DNA synthesis and division which may reflect a coupling mechanism which insures their coordination during the normal cell cycle.


Insecticidal action of carbamates on the eggs of the house cricket.


Enzymic browning of whole wheat meal flour.


The effect of heparin and dipyridamole on chronic vascular lesions in monkey cardiac allografts.


A survey of dairy herd rations in Aberdeenshire.


Au-SH antigen in a hospital population.

Au-SH antigen in a hospital population.


Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.


Rates of nerve impulse propagation as output characteristics--a study on pyramidal tract neurones of cat and monkey.


Tricho-rhino-phalangeal syndrome with hypoglycemia: case report with endocrine function studies.


Clinical immunology. Report of a WHO scientific group.


Listeria monocytogenes sepsis with disseminated intravascular coagulation.


Leukaemia in Nigerians. I. The acute leukaemias.


Species differences in the anticoagulant activities of aflatoxin B 1  and 4-hydroxycoumarin.


Lymphocytotoxins and pernicious anemia.

Lymphocytotoxins and pernicious anemia.


Macroglobulinemia: an analysis for forty patients.


Neural pathways associated with the mesencephalic inhibitory influence on gonadotropin secretion.


Delayed alternation performance and unit activity of the caudate head and medial orbitofrontal gyrus in the monkey.


Functional anatomy of the ankle joint and its relationship to ankle injuries.


Receptive-field organization of monkey superior colliculus.


Meningitis and temporal lobe abscess of dental origin: report of case.


Inability to transmit Breinlia sergenti to other laboratory animals.


Fate of labelled haemoglobin in normal and Plasmodium coatneyi-infected monkeys.


Electron optic microanalysis of two gene products in enamel of females heterozygous for X-linked hypomaturation amelogenesis imperfecta.


Characterization of two new variants of red cell carbonic anhydrase in the British population: CA Ie Portsmouth and CA Ie Hull.


Photic maculopathy produced by the indirect ophthalmoscope. 1. Clinical and histopathologic study.


Solar retinitis and pupillary reaction.

Solar retinitis and pupillary reaction.


Gentamicin penetration in the aqueous humor of eyes with corneal ulcers.


Intraocular penetration of carbenicillin after subconjunctival injection in man.


Aqueous humor pathways through the trabecular meshwork and into Schlemm's canal in the cynomolgus monkey (Macaca irus). An electron microscopic study.


Implantable transducer for in vivo measurement of bone strain.


Computer detection of digitalis toxicity.


The intra-chromosomal distribution of ( 3 H)-dimethylaminoazobenzene in rat liver nuclei in vivo.


The subcellular distribution of tritiated 4-dimethylaminoazobenzene and 2-methyl-4-dimethylaminoazobenzene in rat liver and spleen following a single oral administration.


Antibody deficiency syndrome in patients with multiple myeloma and macroglobulinemia Waldenström.


Isoniazid inactivation in tuberculous patients: a comparative study by vertical diffusion and tube dilution methods.


Esterase isoenzymes from rabbit synovial fluids: normal and artificial joints.


A protein in normal nurse shark serum which reacts specifically with fructosans. I. Purification and immunochemical characterization.


In vivo activity of in vitro immunized lymphocytes. I. Tumor allograft rejection mediated by in vitro activated mouse thymocytes.


Absence of electromagnetic pulse effects on monkeys and dogs.


Reattachment of gingival epithelium to the tooth.


The role of the teaching hospital.

The role of the teaching hospital.


Prothrombin levels maintained with meprobamate and warfarin. A controlled study.


Use of silver sulphadiazine in the treatment of burns at Royal Perth Hospital.


Interaction of viruses and bacteria in host-parasite relations.


A simultaneous outbreak of meningococcal and influenza infections.


The totally self-supporting tooth replica polymer implant.


Histopathologic evaluation of the effects of new polycarboxylate cements on monkey pulps.


Plain views of the orbit.

Plain views of the orbit.


Optic gliomas and pediatric neuroradiology.


WHO Expert Committee on Specifications for Pharmaceutical Preparations. Twenty-fourth report.


Monoamine oxidase in the neurohypophysis of the newt (Cynops pyrrhogaster pyrrhogaster), the toad (Bufo bufo japonicus) and the tortoise (Clemmys japonica).


Experimental enterococcal endocarditis. II. Study of in vivo synergism of penicillin and streptomycin.


The use of tolonium in the diagnosis of malignant gastric lesions.


Inguinal hernia and colorectal carcinoma.


Some effects of propranolol on the cardiovascular responses of the monkey to simulated subarachnoid haemorrhage.


Unusual case of respiratory obstruction during induction of anaesthesia.


Carbonic anhydrase activity in molluscs.


Biosynthesis of alpha-acetolacetate and its converison of diacetyl and acetion in cell-free extracts of Lactobacillus casei.


Serum proteins of the partridge Alectoris graeca.


Anxiety in general practice: 10,703 patients treated with benzoctamine (tacitin). A report of a monitored-release study.


A comparison of diazepam, benzoctamine, and placebo in anxiety states.


Antiparkinson medication in the treatment of extrapyramidal side effects: single of multiple daily doses?


Treatment of orthostatic hypotension in severely disabled geriatric patients.


A multicentre trial of "metosyn"--a new topical steroid in a complex two phase base.


The relief of postpartum pain with Fiorinal.


Effect of phenylhydrazine-induced anemia on the appearance of adult hemoglobin in Rana catesbeiana tadpoles.


Current evaluation of dental implants. Council on Dental Materials and Devices.


The urological problems in space flight.


Anti-Rh therapy after transfusion.

Anti-Rh therapy after transfusion.


Hyperalimentation with amino acid and casein hydrolysate solutions. Mechanism of acidosis.


Guidelines for total parenteral nutrition.


Explanation of rewards that do not reduce tissue needs.


Some metabolic effects of rare-earth cations on Aspergillus niger cells.


Subdeterminants d and y of hepatitis B antigen as epidemiologic markers.


Serum levels of immunoglobulins in Mexican preschool children.


Blocking of induced asthma by cromolyn sodium.


The effect of food deprivation on intergroup relations in rhesus monkeys.


Stimulation of pilus formation in Pseudomonas aeruginosa by RNA bacteriophage adsorption.


Binding and release from cell walls: a unique approach to the purification of autolysins.


The short bowel syndrome.

The short bowel syndrome.


Reduction of the nucleic acid content of single-cell protein concentrates.


Sterilization by electrohydraulic discharges.


A "cradle" for support of roller-bottle-cell cultures during microscopic examination.


3-Hydroxycadaverine, a new substrate for diamine oxidase.


Rat virus infection of megakaryocytes: a factor in hemorrhagic encephalopathy?


De novo protein synthesis during the development of competence in Bacillus subtilis.


The antigenic structure of Francisella tularensis. I. Isolation of the ether antigen and its fractionation.


The menstrual cycle of the bonnet monkey (Macaca radiata). Changes in cervical mucus secretion, vaginal cytology, sex skin and urinary estrogen excretion (with colour plate I).


Unilateral renal aplasia in an African baboon (Papio sp.).


Red cell enzymes and serum proteins of Cercopithecus aethiops (South African green monkey).


The St. Kitts green monkey (Cercopithecus aethiops sabaeus): ecology, population dynamics, and selected behavioral traits.


The population structure of red howler monkeys (Alouatta seniculus) in Trinidad and Venezuela.


Effect of prednisone treatment on the human immune response to keyhole limpet hemocyanin.


Antigenic constituents in pregnancy plasma which are undetectable in normal non-pregnant female or male plasma. To detect antigens in the plasma of pregnant women that were not found in nonpregnant untreated normal women or males, highly sensitive immunodiffusion techniques with hyperimmune rabbit antiserum were used.  The number of pregnancy-associated plasma constituents increased as pregnancy progressed in the 165 patients studied, with all 4 constituents usually seen in the third trimester.  The 60 males and 111 nonpregnant women studied did not show any of these antigens.  There were significant differences between second and third trimester reactions.  (p less than .001).  None of the antigens represented human chorionic gonadotropin, human placental lactogen, oxytocin, C-reactive protein, oxytocinase, alkaline phosphatase, or esterase.  One of these constituents is present during combined estrogen-progesterone therapy.


Studies in immunodermatology. II. Production of pemphigus-like lesions by intradermal injection of monkeys with Brazilian pemphigus foliaceus sera.


Immune responses to the hemocyanin from Limulus polyphemus in allergic and normal individuals.


Formation of a 4-nitroquinoline-I-oxide complex with DNA in normal and repair deficient strains of bacillus subtilis.


Barbiturate withdrawal syndrome in a passively addicted infant.


Investigations on radiosensitive and radioresistant populations of Drosophila melanogaster. II. Restriction of the decrease in radiosensitivity of the irradiated population RO I to stage-7 oocytes.


Dose-response kinetics of genetic effects induced by 250-kVp x-rays and O.68-MeV neutrons in mature sperm of Drosophila melanogaster.


Measurement of radiation-induced dominant lethals in stage-14 oocytes of Drosophila.


Clinical neuropharmacology of hypothalamic releasing factors.


The time sequence of events during excision repair in Tetrahymena pyriformis.


Effect of high-energy x-ray and pulsed gamma-neutron radiation on brain blood flow, vascular resistance, blood pressure, and heart rate in monkeys.


Toxicity of  137 CsCl in the beagle: metabolism and dosimetry.


A progress report of a patient with disseminated cutaneous cardidiasis.


The Task Force Reports on the Cost of Health Services. Where are we two years later?


Selective attention: input filter or response selection? An electrophysiological analysis.


National Purchasing Symposium: current trends in the health field--government's viewpoint.


Effects of experimental ischemia on electrolytes of cortical cerebrospinal fluid and on brain water.


Production of masticatory muscle spasm and secondary tooth movement: an experimental model for MPD syndrome.


Hemodynamic and metabolic concomitants of brain swelling and cerebral edema due to experimental cerebral infarction.


Giant cemento-ossifying fibroma: report of case.


Delayed anemia in erythroblastosis fetalis.


Americium contamination incident in a New York State Health Department laboratory.


High-calorie infusion therapy following surgery in low-birth-weight infants: metabolic problems encountered.


The combined bactericidal effect of acetic acid and a moderate heat treatment in the preparation of a concentrated haemodialysis solution.


Characterization of a transplantable, canine, immature mast cell tumor.


Use of Bacillus Calmette-Guérin as adjuvant in human cell vaccines.


Immunochemical studies on alpha crystallin subunits.


Distribution and movement of sodium and potassium in the toad retina.


An anterior-chamber needle gun.

An anterior-chamber needle gun.


On the pathogenesis of transmissible gastroenteritis of swine.


Comments on the pathogenesis of transmissible gastroenteritis of swine.


Immunology of transmissible gastroenteritis.


Comments on vaccines for transmissible gastroenteritis.


Comments on the immunology of transmissible gastroenteritis.


Isolation and characterization of ultraviolet light-sensitive mutants of the blue-green alga Anacystis nidulans. Three independently isolated ultraviolet light-sensitive (uvs) mutants of Anacystis nidulans were characterized. Strain uvs-1 was most sensitive to UV in the absence of photoreactivation. Pretreatment with caffeine suppressed the dark-survival curve of strain uvs-1, indicating the presence of excision enzymes involved in dark repair. Under "black" and "white" illumination, strain uvs-1 displays photoreactivation properties nearly comparable to wild-type culture. Mutants uvs-35 and uvs-88 appeared to have partial photorecovery capacities. Upon pretreatment with chloramphenicol, photoreactivation properties of strains uvs-1 and uvs-88 were not evident although the partial photoreactivation characteristics of strain uvs-35 remained the same. Data indicate that strains uvs-1, uvs-35, and uvs-88 are probably genetically distinct UV-sensitive mutants.


Tryptophan synthetase in Euglena gracilis strain G. The five enzyme activities in the synthesis of l-tryptophan have been obtained in extracts of Euglena gracilis. One of these, tryptophan synthetase, has been studied in detail. The general catalytic properties of tryptophan synthetase, including the range of reactions catalyzed and its substrate and cofactor affinities, are similar to those reported for other organisms. The Euglena enzyme has two properties never previously observed for tryptophan synthetase. First, the rate of catalysis of the conversion of indole-glycerol phosphate to l-tryptophan remained at its maximal value and was unaffected by the ionic environment up to 0.3 m KCl. In contrast, the conversion of indole to tryptophan showed a sharp maximum at 0.08 m KCl. Second, the enzyme is a component of a complex that includes every enzyme in the pathway committed to tryptophan biosynthesis with the exception of anthranilate synthetase, the regulatory enzyme.


Micro-complement fixation in Klebsiella classification. The alkaline phosphatases of 29 strains of bacteria assigned by various authors to the genera Aerobacter, Klebsiella and Enterobacter were compared by the micro-complement fixation technique. On the basis of phosphatase resemblance, we recommend that all strains hitherto assigned to Aerobacter aerogenes and Enterobacter aerogenes be assigned to the genus Klebsiella.


Protection of normal, lysogenic, and pyocinogenic strains against ultraviolet radiation by bound acriflavine. The presence of bound acriflavine protects bacteria against the lethal effects of ultraviolet (UV) light, presumably because pyrimidine dimer formation is inhibited. Although acriflavine present in plating medium usually results in reduced viable counts from irradiated bacteria, no enhancement of lethal effects is observed when acriflavine is added to irradiated bacteria left in suspending buffer for 45 min before plating. Acriflavine remaining bound to the deoxyribonucleic acid of irradiated bacteria at the time they are plated likewise does not affect their survival. Protection is precisely dose-modifying unless some killing of bacteria by UV results from induction of prophage, against which bound acriflavine is less protective, or from induction of pyocin, against which there is no protection at all. It is inferred that prophage induction proceeds in part, and pyocin induction wholly, by virtue of effects of UV other than pyrimidine dimerization. The response of Escherichia coli strain B to radiation has been postulated to be attributable in part to induction of a prophage or a lethal protein; but exact dose modification was observed for this strain, to about the same extent, whether or not the irradiated organisms were grown in conditions thought to enhance the expected contribution to killing if such a mechanism were involved. Our results support the hypothesis that the inhibition by acriflavine of dimer formation is attributable to energy transfer mechanisms. They fail to support the hypothesis that shapes of survival curves (in particular the manifestation of "shoulders") can be attributed to inactivation by radiation of repair enzymes.


Extracellular alkaline amylase from a Bacillus species. A selective medium was used to isolate a bacterium (Bacillus species NRRL B-3881) that produced extracellular alkaline amylase in an alkaline medium (pH 9.5). Maximal enzyme yield was obtained in an aerated medium after 21 hr at 36 C. The enzyme was purified 18-fold by ultrafiltration and ammonium sulfate precipitation. Three active isoenzymes (one major and two minor) of alkaline amylase were detected by disc electrophoresis in polyacrylamide gel. The enzyme was only 12% inactivated by 20 mm ethylenediaminetetraacetic acid after 1 hr at pH 9.2 and 32 C. The optimal temperature was 50 C at pH 9.2, and the optimal pH was 9.2 at 50 C. The enzyme was stable between pH 7.5 and 10. It had an endomechanism of substrate encounter. The products produced from amylose and amylopectin had the beta-configuration. Cyclomaltoheptaose was hydrolyzed to maltotriose, maltose, and glucose. The main final product produced from amylose and amylopectin was beta-maltose; the other final products were maltotriose and small quantities of glucose and maltotetraose. The predominant product at early stages of hydrolysis was maltotetraose; other products were maltose through maltonanaose.


Buoyant density studies on natural and synthetic deoxyribonucleic acids in neutral and alkaline solutions.


Cellobiose metabolism in Aerobacter aerogenes. 3. Cleavage of cellobiose monophosphate by a phospho- -glucosidase.


Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase.


Chymotrypsin inhibitor I from potatoes. Large scale preparation and characterization of its subunit components.


The biosynthesis of unsaturated fatty acids by bacilli. 3. Uptake and utilization of exogenous palmitate.


Characterization of lysine transfer ribonucleic acid from vegetative cells and spores of Bacillus subtilis.


The biosynthesis of unsaturated fatty acids by bacilli. IV. Temperature-mediated control mechanisms.


-N-benzoylarginine- -naphthylamide amidohydrolase of rat liver lysosomes.


Purification of the bacteriophage SP01 transcription factor 1.


Regulation of hemoglobin synthesis. Equal rates of translation and termination of  - and  -globin chains.


The effects of acetazolamide and amiloride on tissue electrolytes, with reference to the teratogenesis of carbonic anhydrase inhibition.


Effects of pentylenetetrazol on ion transport in the isolated toad bladder.


Phakomatoses.

Phakomatoses.


Pions and heavy ions in radiotherapy.

Pions and heavy ions in radiotherapy.


Microcrystals of a modified fibrinogen.

Microcrystals of a modified fibrinogen.


Polychlorinated biphenyls in carbonless copying paper.


Human growth hormone reaction with tetranitromethane.


Effect of fenfluramine, dexamphetamine and diethylpropion on phosphoglucomutase, 3-phosphoglycerate kinase and pyruvate kinase of mouse muscle.


Cerebral scintigraphy in the diagnosis of intracranial tumours.


Unusual audiometric and histologic findings in bilateral acoustic neurinomas.


Gastrointestinal aspects of Chagas' disease.


Subdural hematoma during long-term hemodialysis.


Clinical investigation of a new podophyllum derivative, epipodophyllotoxin, 4'-demethyl-9-(4,6-O-2-thenylidene- -D-glucopyranoside) (NSC-122819), in patients with malignant lymphomas and solid tumors.


Isolation and characterization of rat   1 -fetoprotein.


Transcortical polarization: facilitation of delayed response performance by monkeys.


Effects of prestriate and striate lesions on performance of simple visual tasks.


Immunologic localization of the human seminal plasma protease inhibitor in human spermatozoa.


Mortality in protein calorie malnutrition.


Mid-upper arm circumference in infants.

Mid-upper arm circumference in infants.


The use of material labelled with soft  -emitters in the Laurell immunoelectrophoretic technique.


Synthesis and structure-activity relationships of disodium cromoglycate and some related compounds.


"Unmasking" of human lymphoid cell heteroantigens by neuraminidase treatment.


History of a rhesus monkey adenocarcinoma containing virus particles resembling oncogenic RNA viruses.


Brief communication: etiological study of a lymphosarcoma in a domestic rabbit.


Retardation of discrimination learning in monkeys and chicks previously exposed to both stimuli.


Further studies on the K + -dependent swelling of primate cerebral cortex in vivo: the enzymatic basis of the K + -dependent transport of chloride.


Human brain-specific alpha 2 -glycoprotein: purification by affinity chromatography and detection of a new component; localization in nervous cells.


The bacteriology of urinary-tract infection.


Effect of formylation on the chromatographic behavior of methionyl transfer ribonucleic acid.


A new assay for cathepsin B1 and other thiol proteinases.


Influence of  -butyrolacton on the histaminase liberating action of heparin and protamine in the guinea-pig.


Reversal of the pressor response of prostaglandin F 2   by polyphloretin phosphate in dogs.


Marijuana: a brief review.

Marijuana: a brief review.


Circular dichroism studies on the copper protein umecyanin.


C-phycocyanin from Oscillatoria agardhil. I. Some molecular properties.


Epidermal structural proteins. II. Isolation and purification of tonofilaments of the newborn rat.


Does oxygen protect against local anesthetic toxicity?


The effect of available dietary zinc on the utilization of protein by the chick and Japanese quail.


Visceral neurofibromatosis. An unusual cause of obstructive jaundice.


Electrophysiologic and behavioral responses to ketamine hydrochloride in the Rhesus monkey.


Immunologic studies of normal, benign, and malignant human prostatic tissue.


Fibrinolysis and peritoneal dialysis in the treatment of diabetic coma, complicated by severe shock. A case report.


Transferrins in Macaca irus.

Transferrins in Macaca irus.


Lung function in cynomolgus monkeys and baboons.


An Escherichia coli antigen cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b: occurrence among known serotypes, and immunochemical and biologic properties of E. coli antisera toward H. influenzae type b.


Interaction in vivo of homocytotropic antibodies belonging to two different rat immunoglobulin classes: effect of IgE on the passive cutaneous anaphylactic reaction mediated by IgG a  antibodies.


Inhibition of antichlamydial IgM antibody by IgG antibody in immunofluorescence tests.


The purification and immunochemical characterization of a new specific antigen, differentially expressed on the surface membranes of mouse lymphoid cells.


The evolution of the immune response. 13. The characterization of purified erythrocyte agglutinins from two invertebrate species.


Effect of mobilization on the blood supply and regeneration of injured nerves.


Inhibition by anti-  chain sera of the cellular transfer of antibody and immunoglobulin synthesis in mice.


Experimental Listeria enteritis. I. An electron microscopic study of the epithelial phase in experimental listeria infection.


An evaluation of hemodilution as therapy for craniocerebral gunshot wounds.


Prisoners as patients.

Prisoners as patients.


The effective lethal phase of the curly mutant in Drosophila melanogaster.


The interferons and their inducers: molecular and therapeutic considerations. 2.


The clinical use of cyanate in sickling.


Some reflections on prebiotic porphyrins and their complexes with other primordial compounds.


Lymphoma and macroglobulinemia.

Lymphoma and macroglobulinemia.


Primate phylogeny and immunological distance. Recalculation of the time of divergence of the Pongidae and Hominidae after correction of immunological distance by inclusion of generation length yields minimum dates of approximately 14 million years ago.


Human virus vaccines: why monkey cells?

Human virus vaccines: why monkey cells?


Percutaneous supraclavicular superior vena caval cannulation.


The gastrojejunostomy efferent loop syndrome.


Histological and ultrastructural changes in rhesus monkey placenta following interruption of fetal placental circulation by fetectomy or interplacental umbilical vessel ligation.


Viron-associated protein kinase and its involvement in nongenetic reactivation of frog polyhedral cytoplasmic deoxyribovirus.


The lymphatic system in rhesus monkeys (Macaca mulatta) outlined by lower limb lymphography.


Serological studies on perinatal Listeria monocytogenes infection.


Triatominae (Hemiptera, reduviidae): sex identification in immature forms of vectors of Chagas disease.


Experimental chemotherapy of schistosomiasis. V. Laboratory trials with U.K. 3883, a 2-aminomethyltetrahydroguinoline derivative.


Immunodiffusion and fluorescent antibody methods to distinguish rod from coccoid forms of a species of Arthrobacter.


Immunochemistry of antigens from aerobically and anaerobically grown Staphylococcus aureus.


Revival and subsequent isolation of heat-injured bacteria by a membrane filter technique. Cultures containing mixed flora from raw milk were heated at 62.8 C for 15, 20, 25, and 30 min. Dilutions were filtered through membrane filters, and the filters were incubated on Trypticase soy broth (TSB) and on TSB plus NaCl (TSBS). The TSB count indicated the total population which survived heating and included injured and uninjured cells. The colonies on TSBS indicated the uninjured cells and were marked by perforating the membrane near the colony. This membrane was then transferred to fresh TSB and incubated further. The injured organisms recovered and formed colonies which could be distinguished from previous colonies of uninjured organisms. Transfer counts on TSB were not substantially different from the initial TSB counts at 15, 20, 25, and 30 min of heating.


Factors affecting comparative resistance of naturally occurring and subcultured Pseudomonas aeruginosa to disinfectants. A strain of Pseudomonas aeruginosa was isolated in pure culture from the reservoir of a hospital mist therapy unit by an extinction-dilution technique; its natural distilled water environment was used as a growth and maintenance medium. After a single subculture on Trypticase soy agar, the strain showed a marked decrease in resistance to inactivation by acetic acid, glutaraldehyde, chlorine dioxide, and a quaternary ammonium compound when compared with naturally occurring cells grown in mist therapy unit water. The following factors were observed to affect the relative resistances of naturally occurring and subcultured cells of the P. aeruginosa strain: (i) temperature at which the cultures were incubated prior to exposure to disinfectants, (ii) growth phase of the cultures at the time of exposure to disinfectants, (iii) nature of the suspending menstruum for disinfectants, and (iv) exposure to fluorescent light during incubation of inocula prior to testing. The applied significance of these findings may alter the present concepts of disinfectant testing as well as routine control procedures in the hospital environment.


Studies of antigens for complement fixation and gel diffusion tests in the diagnosis of infections caused by Brucella ovis and other Brucella. Sonically treated and saline-extracted antigens of Brucella ovis, B. canis, B. abortus, and B. melitensis were compared in gel diffusion, complement fixation, and serum absorption tests. All the sonically extracted antigens showed cross-reactions with sera from animals infected or immunized with these species, whereas the saline-extracted antigens were specific for the surface of the rough or smooth colonial phase of the species or strain. The saline-extracted antigens of B. ovis and B. melitensis were both eluted as a single peak in the void volume by Sephadex G-200 column chromatography, in gel diffusion had staining characteristics of lipoproteins, but in immunoelectrophoresis showed distinct mobility patterns. Serological activity for both gel diffusion and complement fixation tests was demonstrated in the immunoglobulin G-containing fraction of sera taken from sheep 12 to 412 days after infection with B. ovis. The gel diffusion test with saline extract of B. ovis is as sensitive as the complement fixation test for the diagnosis of ram epididymitis and is more practical.


Yellow fever vaccine. V. Antibody response in maonkeys inoculated with graded doses of the 17D vaccine. A dosage equal to or greater than approximately 3.4 Dex (decimal exponent, log(10)) weanling mouse intracerebral 50% lethal dose (LD(50)) was sufficient to elicit a yellow fever antibody response, as determined by the plaque neutralization (PN) test, in better than 90% of vaccinated rhesus monkeys. Lower dosages were progressively less effective in terms of PN titers and the PN and hemagglutination-inhibition serological conversion rates observed. A dose of between 3.4 and 4.2 Dex weanling mouse intracerebral LD(50), or one-tenth to one times the dosage recommended for man, provided an optimal antibody response in monkeys. In rhesus monkeys, in contrast to the findings for man, pre-existing yellow fever antibody did not interfere with the antibody response to yellow fever vaccine. The PN test was felt to be a more sensitive and specific indicator of yellow fever antibody in rhesus monkeys after vaccination than the hemagglutination inhibition or complement fixation tests.


Identification and quantitation of the components of polyvalent inactivated influenza virus vaccines by immunodiffusion. One of the basic problems in the standardization of inactivated polyvalent influenza virus vaccines has been the determination of the relative potency of the individual strain components. The chicken cell agglutination test measures reliably the total hemagglutinin content of these vaccines. With immunodiffusion techniques, it is now possible to quantitate each strain component of polyvalent vaccines. Routine application of these techniques would serve as an interim procedure to assess antigenic potency of individual strain components of commercial vaccines until improved tests are developed.


Evaluation of two commercially available media for detection of bacteremia. Analysis of the results of 13,162 blood cultures during a 9-month interval has shown that Pseudomonas aeruginosa statistically was recovered more frequently from Trypticase soy broth (TSB) than from Thioglycollate-135C and that contaminants, including Staphylococcus epidermidis and aerobic and anaerobic Corynebacterium species, were isolated with statistically greater frequency from Thioglycollate-135C than from TSB. No other statistically significant differences were found.


Comparative immunogenicities of Chikungunya vaccines propagated in monkey kidney monolayers and chick embryo suspension cultures. A comparative study was made of Formalin-inactivated Chikungunya vaccines prepared from the virus propagated in African green monkey kidney monolayers and concentrated chick embryo suspension cultures. The vaccine prepared in the chick embryo suspension cultures was significantly more protective to mice against a live homologous virus challenge and stimulated the production of 4 to 5 times more circulating antibodies than the vaccine prepared with virus grown in African green monkey kidney monolayer cultures.


Susceptibility of cheese and yoghurt starter bacteria to antibiotics. Eight single-strain lactic streptococci, three commercial cheese starters, and six lactic acid bacteria isolated from yoghurt were examined for their susceptibility to penicillin, cloxacillin, tetracycline-hydrochloride and streptomycin. The ranges of the antibiotics causing 50% inhibition of the bacteria were (mug/ml): penicillin, 0.009 to 0.20; cloxacillin, 0.24 to 2.50; tetracycline, 0.09 to 0.60; and streptomycin, 0.35 to 13.0. The average concentrations required to cause 50 and 100% inhibition of the cheese starters were (mug/ml): penicillin, 0.12 and 0.26; cloxacillin, 1.91 and 3.9; tetracycline-hydrochloride, 0.13 and 0.36; and streptomycin, 0.59 and 2.06. All the cocci were about equally susceptible to tetracycline, and all organisms were more resistant to cloxacillin than penicillin. The yoghurt isolates were more resistant to streptomycin and more susceptible to penicillin than the cheese starters. The 2, 3, 5-triphenyltetrazolium chloride test, using Streptococcus thermophilus BC as assay organism, does not detect low levels of streptomycin in milk. However, it is useful in detecting cloxacillin residues.


Neisseria gonorrhoeae: colonial morphology of rectal isolates. Four principal colony types of gonococci have been previously described, and it has been shown that primary isolates from the urethra and cervix are primarily of colony types 1 and 2. In the present work, gonococcal isolates from the rectum were also shown to be predominantly colony types 1 and 2. Visualization and typing of gonococcal colonies in primary rectal isolates were facilitated by the use of medium containing vancomycin, colistin, nystatin, and, in some cases, trimethoprim lactate. Control experiments showed that these agents sometimes caused minor alterations in colonial morphology; but with knowledge of these alterations satisfactory colonial typing could be made.


Storage of conidia of Penicillium chrysogenum in liquid nitrogen. Conidiated slope cultures of derivative of Penicillium chrysogenum Wis 54-1255 were stored at -196 or +4 C for a period of 3.5 years. After this time, the viability fell to 68% in the former case and to 4% in the latter. At the end of the experiment, 65 single conidial isolates from each series were tested for penicillin yield. Among those from conidia stored at -196 C, the spread of penicillin yields did not differ markedly from that of 65 single conidial isolates made as controls prior to storage. However, 18% of those from conidia stored at +4 C formed a subpopulation with substantially lower penicillin titers than those of control isolates. Storage at -196 C may reduce or prevent a possible source of penicillin yield decay, namely, the selection of spontaneous mutants of low titer present in small numbers in the original culture and selected, as viability decreased, by virtue of their increased longevity relative to that of the parental culture.


Tolerance of staphylococcal thermonuclease to stress. Remarkable tolerance to prolonged heating, prolonged storage, and bacterial proliferation was exhibited by staphylococcal thermonuclease in foods and broth. A purified enzyme preparation added to Brain Heart Infusion broth was unaffected by the growth of five bacterial species. Minimal inactivation was effected by Bacillus subtilis. Optimal growth of Streptococcus faecalis var. liquifaciens caused extensive inactivation of thermonuclease. However, storage at room temperature or the addition of 5% NaCl caused only minimal inactivation.


Cadmium and zinc binding in mammalian liver and kidneys.


The actions of prostaglandin E 1 on isolated rabbit aorta.


Evaluation of the effectiveness of colloidal and unsoluble ferrihexacyanoferrates (II) in removing internally deposited radiocaesium.


Treatment of early breast cancer: a report after ten years of a clinical trial. A controlled clinical trial has been carried out to compare radical mastectomy with wide excision (extended tylectomy) in the treatment of early breast cancer. Only patients aged 50 and over were included and 370 entered the trial during a period of 10 years. Postoperative radiotherapy was given in each case. In patients with clinically involved axillary nodes there was a significantly higher incidence of local and distant recurrence in those having a wide excision, and the survival of these patients was significantly less than those who had a radical mastectomy. In patients with clinically uninvolved nodes, although there was a significantly higher incidence of local recurrence in those having a wide excision, there was no increased incidence of distant recurrence and the survival rate was similar to those having a radical mastectomy.


Going abroad.

Going abroad.


The determination of pipecolic acid in serum and urine.


Purification and sensitive immunoelectrophoretical detection and quantitation of human   1 -foetoprotein.


Serum thyroxine after infusion of TRH.

Serum thyroxine after infusion of TRH.


A rare isoenzyme of alkaline phosphatase in 4 patients with ulcerative colitis.


Temperature-sensitive mutation in Drosophila melanogaster. X. Developmental analysis of the paralytic mutation, para ts .


Adipose tissue of Drosophila melanogaster. V. Genetic and experimental studies of an extrinsic influence on the rate of cell death in the larval fat body.


Radiosensitivity of oocytes of Drosophila. I. Sensitivity of class-A oocytes of triploid and diploid females.


Radiosensitivity of oocytes of Drosophila. II. Sensitivity of class-B oocytes of X-X and XY-XY.


Granulocytic leukemia associated with myxedema thyroiditis and myasthenia gravis.


Predictive medicine. XV. Epilogue.

Predictive medicine. XV. Epilogue.


Parenteral hyperalimentation. An adjunct to the management of duodenal fistula. Report of 2 cases.


The fluoride content of army field rations.


Spectacles and contact lenses: a survey of military trainees.


Medicine and United States foreign policy: a partnership for the seventies.


Hallucinogenic drugs and brain damage.

Hallucinogenic drugs and brain damage.


The friction blister.

The friction blister.


A role for the speech pathologist in neuromuscular dyspnea.


Disposition of neuropsychiatric patients at an isolated medical facility.


Acrylic implants for frontal bone defects.


Flight surgeon aircraft investigation guide and kit.


Immunization of monkeys against Plasmodium cynomolgi by X-irradiated sporozoites.


Maintenance of virulent gonococci in laboratory culture.


Determination of nitrogen in living patients.


Action spectra for ultraviolet killing and photoreactivation in the blue-green alga Agmenellum quadruplicatum.


Apparent heterogeneity of serum chorionic somatomammotrophin on gel filtration.


Androstane therapy of aplastic anaemia.

Androstane therapy of aplastic anaemia.


Metabolic aspects of leukemic lymphocyte immune reactivity.


Epsilon-aminocaproic acid for synovectomy in haemophilic patients.


Congenital methemoglobinemia due to diaphorase deficiency.


Erythrocyte content of free protoporphyrin in thalassaemic syndromes.


Von Willebrand's disease: platelet nucleotide alterations in a case with marked platelet adhesiveness and aggregation defects.


Concentration of ampicillin in antral mucosa following administration of ampicillin sodium and pivampicillin.


Analysis of multilocus genetic systems in Tecumseh, Michigan. I. Definition of the data set and tests for goodness-of-fit to expectations based on gene, gamete, and single-locus phenotype frequencies.


Analysis of multilocus genetic systems in Tecumseh, Michigan. II. Consideration of the correlation between nonalleles in gametes.


Polarographic determination of some pharmaceutical products: bromphenindione, trihydroxyethylrutoside, glibenclamide, coenzyme a, doxycycline.


Effects of Medicare on the provision of community health resources.


Stabilizing a gastrostomy tube. A simple effective technic.


Intravenous essential L-amino acids and hypertonic dextrose in patients with acute renal failure. Effects on serum potassium, phosphate, and magnesium.


Compensatory hypertrophy of the gut in an infant with intestinal atresia.


Vascular changes in middle ear effusions.


Primary intratympanic meningioma.

Primary intratympanic meningioma.


Protection by subcellular fractions prepared from lymph-nodes and spleens of specifically allergized C57 BL mice against fatal challenge with BP8 ascites tumour cells in C3H mice.


Crossing over in a double translocation in Drosophila.


Interaction between pteridine synthesis and riboflavin accumulation in Drosophila melanogaster.


Variations between strains of Drosophila melanogaster and D. simulans in giving offspring in interspecific crosses.


The role of brain scanning in the differential diagnosis of seizures. Of 200 patients with seizures who had brain scans, the studies were abnormal in 86% of patients with tumours and in 67% of those with strokes. The scan detected 84% of the 19 potentially curable lesions. There were no false positive studies. Seventy-nine per cent of patients with seizures of less than one year's duration had an abnormal scan; however, the scan was also abnormal in 22% of patients with non-focal seizures of less than one year's duration.


The rifamycins, a unique series of antimicrobials.


A study of 200 cases of active, recent pulmonary tuberculosis treated with rifampin-isoniazid. A follow-up history of one and one-half to three years.


Summation of experimental studies on the action of rifampin.


Intermittent therapy with rifampin once a week in advanced pulmonary tuberculosis.


The antituberculosis efficacy of rifampin in 136 patients.


Rifampin-isoniazid compared with streptomycin-isoniazid in the original treatment of infectious pulmonary tuberculosis. Results of a controlled study.


Antituberculosis activity of rifampin. Report of studies performed and in progress (1966-1971).


Cardiac fatty acids and histopathology of rats, pigs, monkeys and gerbils fed rapeseed oil.


Some chemical and kinetic properties of oyster carbonic anhydrase.


The role of the monkey superior colliculus in eye movement and vision.


Anatomic studies on the superior colliculus.


The primate superior colliculus and the shift of visual attention.


The superior colliculus and pretectum in visual behavior.


Mapping the visual sensory onto the visual motor system.


On the nature of visual-oculomotor connections.


Studies on Mycobacterium chelonei.

Studies on Mycobacterium chelonei.


Bioelectric control of locomotion in the ciliates.


Tetrahymena pyriformis as a model system for membrane studies.


A new species of Kudoa (Myxosporidea: Chloromyxidae) from the spot, Leiostomus xanthurus Lacépède, in Clear Lake, Texas.


The fine structure of Haemoproteus columbae sporozoites.


Development of the polar filament-polaroplast complex in a microsporidian parasite.


Antigenic analysis of virulent and avirulent strains of Trichomonas gallinae by gel diffusion methods.


Analysis of the antigenic relationships among Trichomonas, Histomonas, Dientamoeba, and Entamoeba. II. Gel diffusion methods.


The molecular biology of Euglena gracilis. VII. Inorganic requirements for a minimal culture medium.


Circadian rhythm changes in autotrophic euglena induced by organic carbon sources.


The effects of temperature and heavy water on cell division in heat-synchronized cells of tetrahymena.


Subcellular distribution of aspartate transaminase, alanine amino transferase, glutamate dehydrogenases, and lactate dehydrogenase in Tetrahymena.


Pyridinolcarbamate in the treatment of ischemic heart diseases. A double blind study.


Combination chemotherapy of advanced lymphoma.


The detection of sickle cell hemoglobin in large human populations by an automated technique.


Staging of malignant lymphoma by laparotomy and splenectomy: review of the literature.


A therapeutic milieu program on a military psychiatric ward.


Treatment of the soft tissue war wound by the American military surgeon: a historical resume.


Social work care in an army medical setting.


Treatment and complications of vivax malaria in Vietnam.


Case for diagnosis.

Case for diagnosis.


Military retirement syndrome: the civilian side.


The effects of low dose rate Co60 radiation on susceptibility of mice to respiratory infection with Klebsiella pneumoniae.


Surgical judgment.

Surgical judgment.


Splitbrain monkeys: cerebral control of ipsilateral and contralateral arm, hand, and finger movements. The connections of the descending pathways in the monkey suggest that each hemisphere controls independent arm, hand, and finger movements contralaterally, but mainly arm movements ipsilaterally. This difference could be observed in splitbrain monkeys executing a visuomotor task with one eye covered, provided tactile guidance of the movements was largely prevented.


Polychlorinated biphenyls and DDT alter species composition in mixed cultures of algae. Either DDT or polychlorinated biphenyls were added to mixed cultures containing a marine diatom and a marine green alga that were sensitive and resistant, respectively, to these organochlorine compounds. The diatom grew faster and was therefore dominant in control cultures, but its dominance diminished in treated cultures, even at concentrations of chlorinated hydrocarbons that had no apparent effect in pure cultures. Such stable pollutants could disrupt the species composition of phytoplankton communities, thereby affecting whole eco-systems.


Pharyngo-esophageal diverticulum.

Pharyngo-esophageal diverticulum.


Renal effects of glucagon in rhesus monkeys during hypovolemia.


Problems in the management of popliteal artery injuries.


Persisting streptococcal cell-wall components in murine chronic pyogenic nephritis.


Significance of basal lamina for regeneration of injured lung.


Electron microscopy of the limbal conjunctiva in eyes with pseudo-exfoliation syndrome (PE syndrome).


Electron microscopic study on the so-called malignant medullo-epithelioma (ciliary epithelial carcinoma).


Applying a classification principle of ventricular septal defects to a case with several defects of the interventricular septum.


Prevention of maternal Rh immunization after accidental transfusion of D(Rh 0 )-positive blood.


Administration of synthetic thyrotropin releasing hormone (TRH) as a clinical test for pituitary thyrotropin reserve.


The detection of MNSs "variants" in serial tests with incomplete Rh antisera in saline.


Technical difficulties in interpreting virus-specific IgM antibodies in the presence of rheumatoid factor.


Surgical care study on multiple intraspinal neurofibromas: Von Recklinghausen's disease.


Changes in the pattern of mortality following the eradication of hyperendemic malaria from a highly susceptible community. The population of the sugar estates of the Guyana coastlands was 110 000 in 1966; malaria was eradicated between 1945 and 1951. A study has been made of the pattern of mortality before and after malaria eradication, during the 30-year period from 1937 to 1966.The decline in general mortality has greatly exceeded the fall in mortality specifically related to malaria and has continued for almost 10 years after registration of the last death from malaria. In infants, mortality has been reduced, mainly through a decline in the number of deaths from prematurity and congenital debility that were due mainly to malaria and its sequelae in the expectant mother. In children (1-14 years of age) the decline has resulted from the disappearance of malaria and chronic nephritis as causes of death. In adults, mortality has fallen mainly through the progressive decline in the incidence of a number of diseases not overtly related to malaria: acute and chronic respiratory diseases, chronic nephritis, and the anaemias. Cardiovascular diseases, on the contrary, have shown a tendency to increase since malaria was brought under control.


A comparative clinical evaluation of HAA detection. II. HAA detection among blood donors.


The effect of long-acting glyceryl trinitrate on peripheral circulation.


Dinitrophenyl-reactive immunoglobulins in the serum of normal bowfin, Amia calva.


Radioimmunoassay of Paramoecium surface antigens.


The mechanism of rosette formation between Rh (D)-positive erythrocytes and peripheral blood lymphocytes from Rh isoimmunized individuals. The role of surface micro-projections.


Mechanical extraction of the water-soluble antigen that induces nephrotoxic antiserum from rat glomerular basement membrane.


L-DOPA suppression of thyrotropin-releasing hormone response in man.


Insulin secretion in kwashiorkor.

Insulin secretion in kwashiorkor.


Role of endogenous primate LH in maintaining corpus luteum function in the monkey.


Effects of chronic methadone administration on the hypothalamic-pituitary-thyroid axis.


Increase of serum growth hormone concentration following thyrotropin-releasing hormone injection in patients with acromegaly or gigantism.


An invertebrate coagulation system activated by endotoxin: evidence for enzymatic mediation. Lysates prepared from the amebocytes of Limulus polyphemus, the horseshoe crab, are gelled by endotoxin. Studies were carried out to characterize the components of amebocyte lysate and to examine the kinetics of their reaction with endotoxin. Analysis of amebocyte lysate using sucrose density gradients showed two peaks at 46% and 86% gradient volumes. G50 and G75 Sephadex column chromatography resulted in three protein peaks. One fraction contained a clottable protein, which had a molecular weight of approximately 27,000, and was heat stable. Another fraction contained a high molecular weight, heat labile material, which was activated by endotoxin and reacted with the clottable protein to form a gel. The rate of the reaction between endotoxin and amebocyte lysate was dependent upon the concentration of endotoxin and the concentration of the fraction containing the high molecular weight material. The activity of this fraction was inhibited by diisopropyl fluorophosphate, parachloromercuribenzoate, and para-chloromercuriphenyl sulfonate, suggesting that enzymatic activity depended upon serine hydroxyl and sulfhydryl groups. The reaction between endotoxin and the fractions of lysate was temperature and pH dependent. The data suggest that endotoxin activates an enzyme which then gels the clottable protein contained in amebocyte lysate.


Hypoxanthine-guanine phosphoribosyltransferase: characteristics of the mutant enzyme in erythrocytes from patients with the Lesch-Nyhan syndrome. The Lesch-Nyhan syndrome is characterized clinically by choreoathetosis, spasticity, selfmutilation, and mental and growth retardation. Biochemically, there is a striking reduction of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity in affected individuals. We have examined erythrocytes from 14 patients with the Lesch-Nyhan syndrome for the presence of hypoxanthine-guanine phosphoribosyltransferase activity and enzyme protein. In contrast to the usual finding of no detectable hypoxanthine-guanine phosphoribosyltransferase activity, we have found low levels (0.002-0.79 nmoles/mg protein per hr) of hypoxanthine-guanine phosphoribosyltransferase activity in erythrocyte lysates from five of these patients. In three of the five patients, hypoxanthine-guanine phosphoribosyltransferase activity appeared to be substantially more labile in vivo than normal using erythrocytes which had been separated according to their density (age). Immunochemical studies using a monospecific antiserum prepared from a homogeneous preparation of normal human erythrocyte hypoxanthine-guanine phosphoribosyltransferase revealed immunoreactive protein (CRM) in hemolysate from all 14 patients with the Lesch-Nyhan syndrome. The immunoreactive protein from each patient gave a reaction of complete identity with normal erythrocyte hypoxanthine-guanine phosphoribosyltransferase and was present in quantities equal to those observed in normal erythrocytes. In addition, a constant amount of CRM was found in erythrocytes of increasing density (age) from patients with the Lesch-Nyhan syndrome despite the decreasing hypoxanthine-guanine phosphoribosyltransferase activity. These studies confirm previous data which indicate that the mutations leading to the Lesch-Nyhan syndrome are usually, if not always on the structural gene coding for hypoxanthine-guanine phosphoribosyltransferase. In addition, although the mutant proteins appear to be present in normal amounts, they are often very labile in vivo with respect to enzymatic activity. These observations suggest that therapy directed at stabilization or activation of enzyme activity in vivo may be of potential benefit.


The electrocardiogram (ECG) of the baboon (Papio spp.).


Lung function and blood gas characteristics in the rhesus monkey.


Estimation of the foetal age in pregnant rhesus monkeys (Macaca mulatta) by radiography.


A safe approach to the subclavian vein.

A safe approach to the subclavian vein.


Isolation of tumor-specific antigen from adenocarcinoma of the breast.


Surgical procedures upon juxta-ampullar duodenal diverticula.


Granulomatous ileocolitis with multiple fistulae treated with gut rest, hyperalimentation, and antibiotics. Case report.


Epidemiology of gingivitis and calculus in a marmoset colony.


Activity of some serum enzymes in Downer cows.


Iodide peroxidase activity in the antibacterial system in human parotid and submaxillary saliva.


Changes in blood calcium and magnesium in fasted cows.


Toxicity of fluoride applied topically to the alveolar bone of dogs and monkeys.


Unconventional routes of aqueous humor outflow in Cynomolgus monkey (Macaca irus).


Intravenous nutrition with amino acid solutions in patients with chronic uraemia.


Ocular abnormalities in the cri du chat syndrome.


Noonan's syndrome associated with ocular abnormalities.


Response of Mycobacterium tuberculosis to environmental changes. Survival after transfer from amino-acid-supplemented medium to basal medium.


Incontinentia pigmenti, pheochromocytoma, and ocular abnormalities.


Cyclopentolate associated with two cases of grand mal seizure.


Xenon photocoagulation of the papillomacular bundle. An experimental study.


Ruby laser photocoagulation of the papillomacular bundle. An experimental study.


Optic disc changes in glaucoma.

Optic disc changes in glaucoma.


Screening out a virus-like agent from the testicular suspension of the Nichols pathogenic T. pallidum with observations on certain characteristics of the agent.


Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonococcal and nonspecific urethritis in men.


Doxycycline HCl (Vibramycin) as a single dose oral treatment of gonorrhoea in women.


Comparison of penicillin, tetracycline, and doxycycline in the treatment of uncomplicated gonorrhoea in men.


Serum immunoglobulin levels in gonococcal and non-specific urethritis.


'Triple tetracycline' in the treatment of non-gonococcal urethritis in males.


Rapid blood ketone body estimation in the diagnosis of diabetic ketoacidosis. Different methods of assessing ketone body concentrations in blood and plasma of ketoacidotic patients have been compared. We confirmed that Ketostix reacts strongly with acetoacetate, giving a useful range of 0 to 10 mM for plasma acetoacetate, that acetone reacts weakly, and that 3-hydroxybutyrate does not react at all. Plasma Ketostix readings correlated only moderately well with enzymatically determined whole-blood acetoacetate. All samples giving a + + + reaction contained more than 1.6 mM acetoacetate while only 4 out of 21 samples showing 0 contained more than 0.4 mM. Comparison of Ketostix readings with total blood ketone body content showed poor correlation. One reason for this was the large variation in the ratio of 3-hydroxybutyrate to acetoacetate in ketoacidosis; another was that often Ketostix had been stored in such a way that they had become damp, which impairs their reliability. If the Ketostix reading and estimation of the blood pH show a discrepancy we suggest that an enzymatic assay should be used to determine the ketone bodies and lactate.


Characterization of arylsulfatase isoenzymes from Pseudomonas aeruginosa.


Characteristics of the radiation-induced degradation of DNA in Escherichia coli.


Influence of the age of mycobacterial cultures on the protein and carbohydrate composition of tuberculins.


Dose-dependent viremia and the differential immunoglobulin response of hamsters to Powassan virus.


Analysis of temperature-sensitive sporulation mutants of Bacillus subtilis by transduction.


The occurrence of pyruvic acid ketal in a glucan from a fungus, Microsporum quinckeanum.


Carbonic anhydrase isoenzymes in the gastrointestinal tract.


Peroxisomal enzymes in human granulocytes. I. Catalase and peroxidase.


Distribution of renal blood flow in patients with heart disease.


Ovarian carcinoma: improvement in survival time after chemotherapy.


A comparison of the antigens present on the surface of virus released artificially from chick cells infected with vaccinia virus, and cowpox virus and its white pock mutant. Antisera prepared against vaccinia and cowpox viruses were absorbed with purified suspensions of vaccinia virus, red cowpox and white cowpox viruses. They were then tested for their ability to neutralize the viruses, and to precipitate the virus soluble antigens.The results showed that some virus specific antigens were not virus surface components and that some components were present on the surface of all three viruses. However, certain components were detected on the surface of vaccinia virus but not on the surface of cowpox virus, and vice versa. Some evidence for the existence of a vaccinia-specific surface component was also obtained.Comparisons between results of cross-neutralization tests and immunodiffusion tests on the absorbed sera indicated that antibody to a number of antigens, including the classical LS, and the cowpox-specific d antigen play no part in the process of poxvirus neutralization.


Organic nitrates: relationship between biotransformation and rational angina pectoris therapy.


Effects of anticholinesterase insecticides on hepatic microsomal metabolism.


The effects of Minute loci and the possible involvement of transfer-RNA in sex chromosome non-disjunction in the Drosophila melanogaster male.


Are dicentric anaphase bridges formed by somatic recombination in X chromosome inversion heterozygotes of Drosophila melanogaster?


A model for somatic pairing derived from somatic crossing over with third chromosome rearrangements in Drosophila melanogaster.


Patterns of luteinizing hormone in serum following administration of stalk-median eminence extracts to rhesus monkeys.


Lactogenic activity of human chorionic somatomammotropin in Rhesus monkeys.


Influence of aortic constriction on the positive free-water clearance of primate hemorrhagic shock.


Prevention of the cardiotoxic effects of adriamycin and daunomycin in the isolated dog heart.


Pituitary growth hormone from the turtle and duck: purification and immunochemical studies.


Dynamic behavior of endocardial structures in the baboon heart.


Pyelonephritis. 13. Effect of congenital hydronephrosis on treatment of experimental pyelonephritis.


Studies on a strain of vaccinia virus defective in surface antigen production.


Vitamin B 12  binders in rhesus monkey serum.


Classification and nomenclature of viruses, 1972.


Placental transfer and tissue distribution of ethanol-1- 14 C. A radioautographic study in monkeys and hamsters.


Who pays for medical education?

Who pays for medical education?


The university department of surgery: its structure and role in American medicine.


Persistence of polychlorinated biphenyls in the milk of exposed cows.


Brucellosis in the horse.

Brucellosis in the horse.


An ultrastructural study of fructose-induced hepatic cell injury. Comparison of human and experimental lesions.


Demonstration of the extracellular alveolar lining layer (surfactant) in human lungs. An ultrastructural study.


Nitrogen clearance in horses as a respiratory function test.


Biological activity of phytoestrogens. V. Changes in the energy-providing compounds in the uterus of ovariectomized mice treated with  -sitosterol.


X-linked thrombocytopenic purpura. I. Clinical and genetic studies of a kindred.


Relation of chemical structure to metabolic activity of vitamin B 6 .


Watson's syndrome.

Watson's syndrome.


The relationship of M protein of group a streptococci to mouse virulence.


A double blind trial of the effect of cromolyn sodium on exercise-induced bronchospasm.


Human carbonic anhydrases. 8. Isolation and characterization of polymorphic form of a C type isozyme.


Covalent labeling of the active site of human carbonic anhydrase B with N-bromoacetylacetazolamide.


The purification and properties of sucrose synthetase from etiolated Phaseolus aureus seedlings.


Mechanism of assembly of the outer membrane of Salmonella typhimurium. Site of synthesis of lipopolysaccharide.


Effects of chloramphenicol and cycloheximide on the biosynthesis of mitochondrial ribosomes in Tetrahymena.


One brain--two minds?

One brain--two minds?


Fucosidosis: deficiency of alpha-L-fucosidase in cultured skin fibroblasts.


Complement-dependent platelet injury by staphylococcal protein A. A new example of complement-mediated platelet injury has been described. Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). This reaction is complement-dependent and occurs over a very small range of SPA concentration, larger amounts being inhibitory. Complement fixation by SPA demonstrates the same narrow SPA concentration requirement whereas precipitation of IgG by SPA is roughly proportional to SPA concentration over a wide concentration range. The reaction can be separated into a sensitization step which requires SPA and plasma but not complement, and a release step which does require complement. Complement-mediated platelet damage induced by SPA is a new biologic property of this common component of the cell wall of pathogenic staphylococci which may contribute to the development of inflammatory and thromboembolic reactions complicating intravascular staphylococcal infection.


A method of recording unit activity from ventral temporal cortex in the undrugged and lightly restrained monkey.


An attempt to inhibit the uterine luteolysin in the guinea-pig.


Nonspirochetal chancriform ulcer of the penis--gonococcal or staphylococcal?


Prevention of maternal sensitization to the Rh factor.


Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls. 1. A new simple method is described for quantitating the adhesiveness of circulating polymorphonuclear leucocytes, or granulocytes, to the walls of blood vessels. The cheek pouch of anaesthetized hamsters or a small part of the mesentery of anaesthetized mice were prepared for continuous microscopic observation of selected venules. Those granulocytes which moved sufficiently slowly to be individually visible were counted for 1 or 2 min periods as they rolled past a selected point on one side of a vessel. The velocity distribution of these cells was determined by analysing films. Films were used also to measure mean blood flow velocity in the venules by observing embolizing platelet thrombi induced by the iontophoretic application of adenosine diphosphate. Emigration of granulocytes into the tissues was quantitated by enumerating them in standard areas of stained histological sections.2. In control experiments with hamster cheek pouch venules, the rolling granulocyte count usually passed through a maximum shortly after the preparation was set up and then fell to a low constant value. In mouse mesentery venules the count remained at a low approximately constant value from the beginning for at least 3 hr.3. The mean velocity of blood flow in the venules was between 900 and 200 mu/sec. All rolling granulocytes moved much more slowly; in hamster cheek pouch venules the mean velocity was about 20 mu/sec and in mouse mesentery venules about 10 mu/sec. Around these means the velocity distribution of individual cells was narrow.4. Rolling of granulocytes was abolished by superfusing ethylenediamine tetra-acetate (EDTA, 0.1 M) suggesting that the phenomenon depends on calcium or magnesium ions.5. Agents were applied locally to the observed venules. Human serum albumin, trypsin or histamine in high concentrations did not affect the rolling granulocyte count.6. The rolling granulocyte count was increased during the application of Hammarsten casein or Escherichia coli culture filtrate which are chemotactic to granulocytes in vitro. These agents did not cause alterations in mean blood flow velocity in the observed venules which might have accounted for the effect on the rolling granulocyte counts. When E. coli culture filtrate was perfused through mouse intestine the increase in rolling granulocyte count in the draining venous blood was proportional to the logarithm of the concentration of filtrate.7. The rolling granulocyte count was also increased by the local application of plasma globulin permeability factor or lymph node permeability factor.8. Granulocyte counts in standard histological sections showed no significant increases in control preparations but considerable increases following the application of Hammarsten casein.


Lincomycin in meningococcal infection.

Lincomycin in meningococcal infection.


Collinearity of transcriptional and traditional genetic maps.


Protons in radiation therapy. Comparative dose distributions for protons, photons, and electrons.


Total intravenous feeding.

Total intravenous feeding.


Chronic effects of osmotic opening of the blood-brain barrier in the monkey. In the monkey, the blood-brain barrier and the blood-aqueous and blood-vitreous barriers of the eye can be opened by internal carotid perfusion of solutions of 2 molar urea in a way compatible with survival and, in some few cases, without detectable neurological deficits. Urea presumably acts by osmotically shrinking the endothelial cells of the cerebrovascular vessels and opening their tight junctions. The high incidence of brain necrosis with neurological sequelae after perfusion of urea by the present technique precludes the use of osmotic opening of the blood-brain barrier for pharmacotherapy at this time.


Optical modulation by the isolated retina and retinal receptors.


Some aspects of tranquilization and anaesthetization in the goat.


Lactic acidosis in phenformin-treated diabetics. A clinical and laboratory study.


Human listeriosis. Diagnostic, epidemiological and clinical studies.


Management of Pierre Robin syndrome in infancy by prolonged nasoesophageal intubation.


Some innovations in the managment of enterocutaneous fistulas.


Effect of injected human immunoglobulins on fetal rat development. Spinal, neural and osseous changes.


Expansion of placental site and maternal blood supply of primate placentas.


Extrapyramidal monosynaptic and disynaptic control of mammalian alpha-motoneurons.


Developmental aspects of pyramidal motor control in the rhesus monkey.


Complete unilateral section of the pyramidal tract at the medullar level in Macaca mulatta.


Activity of basal ganglia neurons during movement.


Static and phasic muscle activity of monkeys with pyramidal lesions.


Operant conditioning of isolated activity in specific muscles and precentral cells.


Contrasts between activity of precentral and postcentral neurons of cerebral cortex during movement in the monkey.


Functional role of afferent inputs to the monkey motor cortex.


Two modes of active eye-head coordination in monkeys.


On the significance of various command signals during voluntary control.


Relating motor cortex spike trains to measures of motor performance.


Task-related discharge of neurons in motor cortex and effects of denatate cooling.


Cerebellar output: properties, synthesis and uses.


Serum IgE concentrations in hypogammaglobulinaemia and selective IgA deficiency. Studies on patients and family members.


Detection of Australia antigen by biological assay in 'Au negative' kidney homograft recipients with hepatic dysfunction.


Antigenic relationship between human IgE and canine IgE.


Placental transfer of human IgG subclasses.


Myasthenia gravis. Antibodies to an acid-soluble antigen in striated muscle.


Increased adenosine triphosphate concentration in erythrocytes in neurofibromatosis.


The Aicardi syndrome.

The Aicardi syndrome.


The effect of eye reduction on white position-effect variegation in Drosophila melanogaster.


Pattern of DNA segregation in multipolar anatelophases of different ploidy in euploid and aneuploid mammalian cells cultivated in vitro.


Patterned disjunction in Drosophila melanogaster. I. Assortment of SPA pol - +  and X,Y in the stock N1.


Hemocyanin from Dolabella auricularia. II. Dissociation by EDTA and re-association by calcium ion.


On the relationship between stored sperm and progeny produced in females of Drosophila melanogaster.


Sensitivity of Escherichia coli to viral nucleic acid. 3. Competence of glycine-spheroplasts.


Purification and properties of whale thyroid-stimulatin hormone. II. Isolation of multiple components.


Characteristics and response-displacement effects of shock-generated responding during negative reinforcement procedures: pre-shock responding and post-shock aggressive responding. Bar-pressing (Experiment I) or key-pressing (Experiments II and III) responses of monkeys were reinforced according to a fixed-interval schedule of negative reinforcement: the first response after a fixed interval of time terminated regularly spaced shocks for a fixed time designated as the reinforcement period. During extinction, shocks continued during the reinforcement period. That there were two types of responding generated by shock alone was indicated by (1) the level of responding maintained during extinction relative to conditions without shock, (2) the stability of two between-shock response patterns across reinforcement and extinction conditions, and (3) the development of these two between-shock patterns without a history of reinforcement. Subjects developed either a pre-shock or a post-shock response pattern when only the bar was available. However, when both a bite tube, an operandum requiring an aggressive topography, and a recessed key, an operandum that did not require an aggressive topography, were provided, the post-shock pattern was observed in tube biting and the pre-shock pattern was observed in key pressing. Removal of the bite tube produced post-shock key responding similar to that observed when only the bar was available. The displacement of post-shock, aggression-motivated responding confirmed the confounding effect of shock-generated responding in negative reinforcement procedures, and suggests that the use of concurrent response alternatives would reduce such confounding.


Avoidance responding as a function of stimulus duration and relation to free shock. Response-independent pairings of a tone and a brief shock were superimposed on uncued avoidance responding in four groups of rhesus monkeys. For one group, tone presentations were immediately followed by an unavoidable electric shock; for the remaining groups, gaps of 5, 20, and 80 sec intervened between tone termination and shock delivery. These temporal values subsume paradigms usually treated as discrete procedures; the conditioned emotional response procedure (0-sec gap between tone and shock), trace procedure (5-sec gap) and safety-signal training (80-sec gap). Within each group, tone durations of 10, 20, 40, and 80 sec were examined. A response pattern marked by maximum response rate in the initial 5 sec of the tone followed by deceleration before shock was observed when shock immediately followed the tone, but not when gaps were interposed between the tone and shock. Response rates in the first 5 sec of the tone were a function of both tone duration and duration of the gap. When the gap was 0 to 5 sec, initial response rates were highest in longer duration tones; this relationship between tone duration and initial tone response rate was not observed for longer gaps.


Tryptic inhibition of vitamin B 12  uptake by ileal homogenate. A method for the quantitation of   1 -antitrypsin in serum.


Detection of increments in noise intensity by monkeys. Monkeys were trained to detect 100-msec increments in the intensity of continuous white noise. A response on one of two bars was reinforced with some probability if it conformed to the presence or absence of the increment on that trial. Stimulus parameters of background intensity, increment size, and probability of increment presentation were varied, and response probabilities and latencies were recorded. The task was analogous to the "yes-no" task used in human psychophysics. Data analysis within the context of signal-detection theory revealed response biasing toward one bar or the other to be related to the probability of increment presentation, whereas sensitivity depended on the combination of increment size and background noise intensity. Weber's law was found to hold for a large range of background intensities in that the sensitivity to relative intensity increments varied little. Performance was compared to that of an ideal observer that uses samples of the envelope of the noise waveform on which to base its responses.


Design and calibration of a "broad-beam"  238 Pu, Be neutron source for total-body neutron activation analysis.


Nephrocalcinosis as a source for renal stone nuclei. Observations on humans and squirrel monkeys and on hyperparathyroidism in the squirrel monkey.


The effect of progesterone on ureteral physiology in a primate model.


Vesicoureteral reflux associated with congenital bladder diverticulum in boys and young men.


EDTA and lysozyme lavage in the treatment of pseudomonas and coliform bladder infections.


Treatment of genitourinary tuberculosis: report after 24 years.


Renal carcinoma (hypernephroma) occurring in 5 siblings.


Chlorthalidone-induced hyperosmolar hyperglycemic nonketotic coma.


Radiotherapeutic approach.

Radiotherapeutic approach.


Mycetoma of the foot caused by Nocardia brasiliensis.


Practical aspects of immunological assays.


Hyperalimentation: value and technique.

Hyperalimentation: value and technique.


The fate of corpuscular antigen in leukocyte migration cultures.


Human migration inhibition factor: a preliminary report.


A new bacteriophage typing set for Pseudomonas aeruginosa. 1. Selection procedure.


A new bacteriophage typing set for Pseudomonas aeruginosa. 2. Characterization and comparisons of new and previous typing sets.


Immunoglobulins in bovine lachrymal fluid.


Antigenic studies of genus Micrococcus. 2. Double diffusion in agar gel with particular emphasis on teichoic acids.


Heterogeneity in the reactivity of antibodies with kaolin.


An alternative procedure for production of anti-Lp(a) serum.


Psychosomatics and chronobiology: possible implications of neuroendocrine rhythms. A review.


Content in cell cultures of complement esterase and two further esterases mainly hydrolysing ethyl esters of acetyl-L-phenylalanine and acetyl-L-tryptophan, respectively.


Labelling of DNA and RNA from thymine and thymidine in Neisseria meningitidis.


A new antigen complex co-occurring with Australia antigen.


Studies on the mode of action of 3-deazapyrimidines. 1. Metabolism of 3-deazauridine and 3-deazacytidine in microbial and tumor cells.


Effects of selected chelating agents and metals on the stability of liver lysosomes.


Further studies of plasminogen proactivator.


Conformation and some properties of  -casein-like fraction of human casein.


Isolation of II-S IgA from porcine milk.


The vitamin B 12 -binding protein in human saliva. Isolation, characterization and comparison with the unpurified protein.


Immunological patterns of "typical" and Runyon's group I mycobacteria determined by cytoplasm antigens.


On the heterogeneity of staphylococcal enterotoxin C 2 .


Synthesis of a peptide with cobrotoxin activity.


Preparation of spheroplasts from Streptococcus lactis.


The formation of rhizopterin and formylated folate polyglutamates during the growth of Staphylococcus epidermidis.


Characteristics of an aminopeptidase activity from the cultural fluid of Bacillus subtilis.


The effect of thioglycolic acid or propanol pretreatment on lysing of Streptococcus lactis with lysozyme and salt.


Sensitivity of normal and mutant strains of Escherichia coli to actinomycin-D.


The catabolism of human  G immunoglobulins of different heavy chain subclasses. 3. The catabolism of heavy chain disease proteins and of Fc fragments of myeloma proteins.


Chemical aspect of penicillin allergy: the reaction of penicillins with imidazole.


Individual antigenic specificity and cross-reactions among amyloid preparations from different individuals.


Isolation and characterization of carcinoembryonic antigen.


Resolution of the first component of guinea pig complement into three subunits, Clq, Clr and Cls, and their hybridization with human Cl subunits.


Early secondary disease in the rhesus monkey. II. Electron microscopy of changes in mucous membranes and external epithelia as demonstrated in the tongue and lip.


Some problems in thyroid diagnosis.

Some problems in thyroid diagnosis.


Demonstration of collagen in human tissues by immunofluorescence.


Polychlorinated biphenyls: comparative effects of high and low chlorine containing Aroclors on hepatic mixed function oxidase.


The role of bacterial contamination in isolated toad urinary bladder: effect of antibiotics on aldosterone-stimulated active sodium transport and RNA specific activity.


Melanophore stimulating hormone: release inhibition by ring structures of neurohypophysial hormones. Tocinamide and tocinoic acid, ring structures of oxytocin, are potent inhibitors of the release of melanophore stimulating hormone from the rat and hamster pituitary in vitro. Tocinamide is effective at concentrations as low as 10-(14)M on the mammalian pituitary. These peptides do not affect release of the hormone on the frog (Rana pipiens) pars intermedia, but they do inhibit release in the bullfrog (Rana catesbeiana) and the toad (Bufo marinus). The specificity of the peptides on inhibition of the hormone is demonstrated by the fact that oxytocin, lysine vasopressin, and pressinoic acid and pressinamide (ring structures of the vasopressins) do not show such inhibitory activity. Hypothalamic extracts of either the frog (Rana pipiens) or the rat inhibit release of the hormone from pituitaries of either species. The inhibitory effects of tocinamide and tocinoic acid, like that of hypothalamic extracts, are reversible.


Pharmacology of the bronchi.

Pharmacology of the bronchi.


Exercise-induced airways constriction.

Exercise-induced airways constriction.


Botulism as a factor in waterfowl mortality at St. James's Park, London.


Darting of pigtail macacque (Macaca nemestrina) using an etorphine mixture.


An instrument for measuring radial immunodiffusion precipitates.


Intestinal absorption of immunoglobulins by newborn infants.


Premature rupture of membranes and effects of prophylactic antibiotics.


Time course of effect of disodium cromoglycate on exercise-induced asthma.


Historical perspective--viral hepatitis.


Lymphocyte transformation in malnourished children.


Deaths from acute lead poisoning.

Deaths from acute lead poisoning.


Antibacterial properties of silver chelates of uracil and uracil derivatives in vitro.


Cephalexin in gonorrhea.

Cephalexin in gonorrhea.


Principles of methodical studies on capillaries in the light of the immunomorphogenesis of the capillary-haemopoietic system. I. Immunobiogenetic studies.