Studies on the relationship between plasma free fatty acids and growth hormone secretion in man. The influence of plasma free fatty acid (FFA) concentration on the secretion of human growth hormone (HGH) was investigated. (a) FFA depression was produced by means of a nicotinic acid (NA) infusion for either 1 or 5 hr in the presence of glucose-induced hyperglycemia. Controls received only saline. (b) FFA depression was also produced by a 90 min NA infusion and then rapid FFA elevation by a lipid-plus-heparin (lipid) infusion. This procedure was compared with a similar NA infusion not followed by lipid. (c) FFA elevation was produced either by a lipid or by a norepinephrine (NE) infusion and then HGH secretion was stimulated by insulin-induced hypoglycemia. Each subject in this group received both the lipid and the NE infusion on seperate days as well as two control tests (insulin alone and NE alone). Depression of FFA resulted in an increase of HGH with a lag period of approximately 2 hr. Maximal HGH rise after 1 hr NA infusion was 7.7+/-1.9 ng/ml and with 5 hr NA infusion 14.3+/-3.6 ng/ml (both significantly higher than during saline infusion, P < 0.025 and < 0.005 respectively) and occurred despite continuous hyperglycemia. Lipid infusion just before the expected HGH increase prevented the HGH response to FFA depression. HGH rise during insulin hypoglycemia (32.2+/-6.5 ng/ml) was significantly inhibited by prior FFA elevation whether achieved by lipid infusion (maximum HGH rise 11.4+/-1.6 ng/ml) or by NE infusion (maximum HGH rise 19.0+/-6.2 ng/ml). The results are suggestive of a negative feedback loop between plasma FFA and HGH secretion, of importance for subacute rather than acute changes in the plasma FFA concentration. FFA lack itself seems to be the signal for HGH release despite the lag period between FFA decrease and HGH increase. Glucose and FFA can at least not fully replace each other in their respective influence on HGH release.


Differential permeability of the proximal and distal rabbit small bowel. The permeability of the proximal and distal rabbit intestine for two to six carbon polyhydric alcohols was compared. Intestinal segments were mounted in chambers that permitted the measurement of the unidirectional flux across the brush border membrane. For both proximal and distal intestine, the permeability for a series of polyhydric alcohols decreased with increasing size. The proximal intestine was more permeable for four, five, and six carbon polyhydric alcohols than distal intestine. This regional permeability difference can be attributed to variations in the permeability characteristics of the brush border specifically. The uptake of alcohols was nonsaturable and was not inhibited by phlorizine or n-ethylmaleimide. The results are compatible with the concept that the brush border membrane has properties similar to artificial porous membranes and that the equivalent radius of the pores of the proximal intestine exceeds that of the distal gut.


Lymphotoxin formation by lymphocytes and muscle in polymyositis. Muscle pieces from 11 patients with dermatomyositis or polymyositis were incubated with autologous peripheral blood lymphocytes and the supernates examined for the production of lymphotoxin, a mediator of delayed hypersensitivity, using human fetal muscle monolayers as the target cell. In the case of all 10 active patients, production of lymphotoxin was demonstrated. This mediator was also demonstrated when muscle alone was incubated from two patients with extensive cellular infiltration. Lymphotoxic activity was not found in supernates obtained by incubation of muscle from nine control subjects with their autologous peripheral blood lymphocytes. Addition of methyl prednisolone to active cultures inhibited the action of lymphotoxin on the muscle monolayers. Lymphotoxin was not demonstrated when breast tumor tissue from a patient with dermatomyositis was incubated with autologous lymphocytes. The lymphotoxic agent in the active supernates had similar chromatographic properties to those of a sample of purified lymphotoxin. These findings suggest that muscle injury in polymyositis is a result of a cellular immune response to an antigen present in involved muscle tissue.


Bilirubin conjugates in bile of man and rat in the normal state and in liver disease. Conjugates of bilirubin were studied in normal bile of man and rat, and in bile of liver patients. In general human bile was obtained by duodenal intubation. In addition T-tube bile was examined in patients operated on for mechanical obstruction. The bile pigment compositions of duodenal and T-tube bile were similar in two patients where comparison was possible. Obstruction of the bile duct in rats was used as an animal model for obstructive jaundice. Diazotized ethyl anthranilate was used for determination of total conjugated bile pigment and for thin-layer chromatography (t.l.c.) analysis of the derived azopigments. The available t.l.c. procedures are versatile and allow rapid and quantitative analysis. A variety of conjugated azopigments can be distinguished. With chloroform, negligible amounts of unconjugated bilirubin are extracted from bile of man. Therefore, the percentage of monoconjugated bile pigments present in the initial bile sample can be calculated from the percentage of azodipyrrole found after diazotization. Normal bile from man and rat yields similar azopigment patterns. The dominant component is azopigment-delta (azodipyrrole beta-D-monoglucuronoside). Small amounts of azopigments with complex conjugating structures (gamma-azopigments) are present in both cases. Human bile further yields small amounts of azopigments containing xylose or glucose (called azopigments-alpha(2) and -alpha(3), respectively). Monoconjugated bilirubin (estimated from the percentage of azodipyrrole) amounts of 22% of total bile pigments in human bile and to 39% in murine bile. In both, the bulk of bile pigment is bilirubin diglucuronoside. From bile of patients with acquired liver diseases a new azopigment group (beta-azopigment) was derived. The gamma-azopigment group was increased; the delta-azopigment group (containing azodipyrrole beta-D-monoglucuronoside) was decreased. No differentiation was possible between intra- and extrahepatic cholestasis. The percentage of beta-azopigment showed a positive correlation with serum bilirubin concentration (r = 0.6). Recovery of the diseases was accompanied by normalization of the azopigment patterns. In rats, hydrostatic or mechanical obstruction induced increases in beta- and gamma-azopigments and a decrease in delta-azopigment similar to the changes observed in bile of liver patients. Complete normalization was obtained 6 hr after relieving the hydrostatic obstruction (duration 15-21 hr). In contrast, with man after surgery for extrahepatic obstruction, T-tube bile was not normalized when the T-tube was withdrawn (10 days after operation). Hydrostatic obstruction in rats provides an easy model when postobstructive bile pigment composition and parameters have to be investigated. The present investigations stress the importance of the physiopathological state when studying bilirubin conjugation. Hindrance to bile secretion induced heterogeneity of bilirubin conjugates and stimulated the formation of complex structures.


Rat liver adenyl cyclase activity in various thyroid states. Thyroidectomized and euthyroid rats were injected with three doses of triiodothyronine (T(3)) or of the diluent over a 6 day period, and liver homogenates were assayed for basal, epinephrine-stimulated, and NaF-stimulated adenyl cyclase activity. Based on NaF-stimulated levels, total adenyl cyclase activity, expressed per milligram of liver protein, was increased after thyroidectomy. Administration of T(3) to either hypothyroid or euthyroid rats, however, had no effect on the NaF-stimulated levels. Basal and epinephrine-stimulated enzyme activities were the same in hypothyroid, euthyroid, and hyperthyroid (euthyroid + T(3)) liver homogenates. In contrast, injections of T(3) in hypothyroid rats increased the activities of basal and epinephrine-stimulated adenyl cyclase. In view of the findings in euthyroid and hyperthyroid liver, it is possible that this effect is transient. In general, no correlation was found between the effects of thyroid hormone on respiration and on adenyl cyclase activity of the rat liver. These results imply that the hepatic thermogenic response to thyroid hormone is not mediated by stimulation of adenyl cyclase activity with the possible exception of the early effects of T(3) in the athyroid rat.


Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone. 6-n-propylthiouracil (PTU) administered to male Sprague-Dawley rats maintained on 2 and 5 mug L-thyroxine (T(4))/100 g body weight resulted in a marked reduction in the rate of conversion of L-thyroxine to L-triiodothyronine (T(3)). These effects could not be ascribed to induced hypothyroidism since the group maintained on 5 mug T(4)/day had normal levels of liver mitochondrial alpha glycerophosphate dehydrogenase. In confirmation of previous studies, PTU also reduced the fractional rate of deiodination of T(3). These observations provide a possible explanation of the many published observations indicating that PTU antagonizes the tissue effects of T(4) but not of T(3). The data suggest that monodeiodination of T(4) but not of T(3) is essential before hormonal effects can be manifested at the cellular level.


The synthesis of 6-substituted thieno(3,2-b)pyrroles. Analogs of tryptophan, tryptamine, and indoleacetic acid.


Quantitative studies of the delivery of hepatic-synthesized bilirubin to plasma utilizing  -aminolevulinic acid-4- 14 C and bilirubin- 3 H in man. After the simultaneous intravenous administration of unconjugated bilirubin-(3)H and delta-aminolevulinic acid-4-(14)C, the plasma disappearance curves of unconjugated bilirubin-(3)H and the plasma appearance curves of biosynthesized unconjugated bilirubin-(14)C have been defined in seven patients, three of whom had acute intermittent porphyria (AIP). The incorporation of (14)C into plasma unconjugated bilirubin, derived by an analysis which involves deconvolution of the two plasma curves, varied between 13.1 and 23.5% (mean 19.3%) of the injected dose in the nonporphyric patients and between 5.4 and 13.6% (mean 8.3%) of the injected dose in the porphyric patients. In five of the patients, the stercobilin-(14)C specific activity in a pooled specimen of feces was measured, enabling the following further values to be calculated: (a) the total (14)C radioactivity incorporated into bilirubin (21.0 and 25.3% [mean 23.2%] of the injected dose in two of the nonporphyric patients and between 8.5 and 25.3% [mean 14.2%] of the injected dose in the porphyric patients), and (b) the proportion of hepatic synthesized bilirubin delivered directly to plasma in the unconjugated form (between 0.520 and 0.904; mean for nonporphyric patients 0.712; mean for porphyric patients 0.614). The results demonstrate that a large proportion of bilirubin derived from hepatic hemes passes through the plasma in the unconjugated form before conjugation and secretion into bile.


Studies of the synthesis of cephalotaxine. I.


The direct utilization of unsaturated sugars in nucleoside syntheses. The synthesis, configuration, and conformation of certain hex-1-enitol-3-yl, hex-2-enopyranosyl-, and hexopyranosylpurines. The preparation of 9-(1,5-anhydro-2,3-dideoxy-D-arabino-hex-1-enitol-3-yl)adenine and 9-(2,3-dideoxy- -D-erythro-hex-2-enopyranosyl)adenine from D-glucal.


The reaction of steroidal 3-keto-19-carboxylic acids and 19-nor steroidal dienones in solutions of iodine in pyridine.


Basic hydrogen peroxide cleavage of a bicyclic ketone. A new procedure for a prostaglandin intermediate.


Disaccharide nucleosides of benzimidazole.


Blood pressure proximal and distal to arterial obliterations in the lower limb.


The truth about medical meetings.

The truth about medical meetings.


From a malpractice lawyer's case book.

From a malpractice lawyer's case book.


The promise of interferon.

The promise of interferon.


Hyperuricemia: when does it signify gout?


The bachelor with bilateral pneumonia.

The bachelor with bilateral pneumonia.


Are we prescribing too many tranquilizers?


Methadone--curse or cure?

Methadone--curse or cure?


Isolation of Japanese encephalitis virus and a hemagglutinating DNA virus from the brain of stillborn piglets.


Biological and physicochemical properties of porcine parvovirus recovered from stillborn piglets.


Senotypes of Mycobacterium intracellulare of porcine origin.


Copper, iron, and zinc contents of pasture grass and serum of grazing cattle.


Carcinoma in situ of the urinary bladder. Flat intra-epithelial neoplasia.


Continuous recording of urinary flow-rate.


Glomerular filtration rate measurement and  131 I-hippuran renography before unilateral nephrectomy.


Eosinophiluria.

Eosinophiluria.


Trimethoprim in human prostatic tissue and prostatic fluid.


Magnesium-containing antacids to patients with uremia--an intoxication risk.


Comparison of two parallel-flow disposable artificial kidneys.


Adenomatoid tumours of the urinary bladder.


Primary tumours of the ureter.

Primary tumours of the ureter.


Acute hypertension following trauma to hydronephrotic kidney. Case report.


Sarcoidosis with hypercalcemia, reversible uremia and hyperparathyroidism.


The process of recovery after hemiplegia.


Experimental brain ischemia: protection from irreversible damage with a rapid-acting barbiturate (methohexital).


Cerebral anoxia: protein metabolism during recovery in in vitro model.


Diagnostic information available in university and community hospital medical records: patients with cerebrovascular disease.


Postoperative recovery of ureteral peristalsis.


Non-incidental concomitancy of gastric and duodenal ulcers.


The mechanism of calcification in necrotic foci and its biological significance.


The outcome for patients with cerebrovascular disease in university and community hospitals.


Clinical prevention of stroke.

Clinical prevention of stroke.


Identification of individuals with covert ischemic thrombotic cerebrovascular disease: a discriminant function analysis.


An experimental study on the time factor in radiation treatment of cancer.


Tetrodotoxin and Ciona heart.

Tetrodotoxin and Ciona heart.


Continuous in situ determinations of the blood O 2  content by an oximetric method.


Effects on A-V conduction of tetrodotoxin selectively injected into the A-V node artery of the dog.


Changes in fertility and morphology of sensitized rat uterine endometrium upon an intra-uterine injection of antigen. To correlate fertility and endometrial morphology during an immune reaction, pregnant rats previously immunized with BCG vaccine were injected with .05 ml BCG vaccine in 1 uterine horn on Day 3 of pregnancy and the number of fetuses counted  during Days 10-16.  Spayed animals were given progesterone for 4 days and then an injection of BCG serum or vaccine in 1 uterine horn.  The uteri were studied microscopically at intervals after injection.  An intrauterine injection of BCG vaccine completely inhibited implantation.  An intrauterine injection of serum to immunized or nonimmunized animals did not block implantation but seemed to lower fertility.  Electron microscopy of the uteri of vaccinated spayed progesterone-treated animals showed an extensive development of the Golgi apparatus and granular endoplasmic reticulum.  Large vacuoles were present, but there was a disappearance of the apical vesicles which are characteristic for a normal preimplantation stage in the rat.  In the immediate type of hypersensitivity, the uterine epithelium is insufficiently changed to inhibit implantation.


On the etiology of periarthritis humero-scapularis.


A method for temperature variation and control of an isolated heart muscle bath, using Peltier effect semiconductors.


Central haemodynamics at rest and during exercise in severe chronic obstructive lung disease.


P-wave analysis in chronic obstructive lung disease with pulmonary hypertension.


Motility of the human digestive tract under resting conditions and after ingestion of food. A study with endoradiosondes.


Angiography of the pancreas and the liver. A clinical evaluation of the method.


Glucagon and gastrointestinal motility in relation to thyroid-parathyroid function.


Physical working capacity in severe chronic obstructive lung disease.


Numerical analysis of the vestibular nerve in man. A preliminary report.


Postoperative motility of the small intestine. A study with endoradiosondes.


Investigation of oxygen exchange in human paranasal sinuses with a small P O2 -electrode.


Optic atrophy as a primary presentation in Nigerians (an evaluation of 95 patients).


Congenital malformations of the central nervous system in Nigeria.


A review of Stevens-Johnson syndrome at the University College Hospital, Ibadan.


Report of a study of rifampicin in the treatment of pulmonary tuberculosis.


Cellulose acetate electro-osmosis in the diagnosis of the haemoglobinopathies.


Some observations on the life-cycle of Reighardia sternae Diesing 1864 (Pentastomida).


Plaque test and biological properties of bovine herpes mammillitis (BHM) virus.


Preparation and evaluation of inactivated Venezuelan equine encephalitis vaccines.


The vascularisation of the homogenous tendon graft: an experimental study.


A modified intramedullary nail.

A modified intramedullary nail.


A farewell to arms.

A farewell to arms.


Reye's syndrome. I. Blood ammonia and consideration of the nonhistologic diagnosis.


Reye's syndrome. II. Occurrence in the absence of severe fatty infiltration of the liver.


Cerebro-hepato-renal syndrome of Zellweger. Two patients with islet cell hyperplasia, hypoglycemia, and thymic anomalies, and comments on iron metabolism.


Immunity to measles in children vaccinated before and after 1 year of age.


Measles in previously vaccinated children. Evaluation of an outbreak.


Dermatoglyphics in distal phalangeal hypoplasia.


Height and weight of 7,500 children of three skin colors. Pediatric multiphasic program: report no. 3.


Oculocerebrorenal syndrome. (Lowe syndrome).


Hypotonia and the maternal-child relationship.


Clinical pharmacology of gentamicin in infants 2 to 24 months of age.


An 18p21q translocation in a patient with presumptive "monosomy G".


Tick paralysis. Case report with emphasis on neurological toxicity.


The Holt-Oram syndrome with previously undescribed associated anomalies.


Linear sebaceous nevus syndrome.

Linear sebaceous nevus syndrome.


The Kleeblattschädel phenomenon: sign or syndrome?


Pyogenic abscess of the liver.

Pyogenic abscess of the liver.


Survey of chronic pancreatitis in a veteran population.


Hepatitis in drug users.

Hepatitis in drug users.


The radiology corner. Lipoma of the colon.


The maintenance of the circulation during anaesthesia in patients with phaeochromocytoma.


Postoperative vomiting after different modes of general anaesthesia.


Effect of ligation of the hepatic artery on drug metabolism by liver microsomal enzymes.


The metabolic response of the liver when acute experimental haemorrhagic shock is treated with dextran or gelatin-type plasma expanders.


Intestinal obstruction caused by gallstones.


Carcinoma of the cystic duct.

Carcinoma of the cystic duct.


Bioassay system for formulations of topically applied glucocorticosteroids.


Occlusive appliance for chemotherapy.

Occlusive appliance for chemotherapy.


Vitamin A acid in the treatment of palmoplantar keratoderma. Clinical investigations and experimental results with 13 patients.


Actinic keratoacanthoma.

Actinic keratoacanthoma.


Palisaded, encapsulated neuromas of the skin.


Systematized hypochromic nevus. Incontinentia pigmenti achromians of Ito.


Pigmented nevi of sole. A report of two cases with histologic evidence of hair follicle formation.


Seasonal trichorrhexis nodosa. Role of cumulative damage in frayed hair.


Umbilical pilonidal sinus.

Umbilical pilonidal sinus.


Subcutaneous sarcoidosis with calcification.


Psoriasiform sarcoidosis.

Psoriasiform sarcoidosis.


Lipodystrophia centrifugalis abdominalis infantilis.


Keratosis follicularis. (Darier's disease). Response to simultaneous administration of vitamins A and E.


Acral arteriolar ectasia.

Acral arteriolar ectasia.


Scarring alopecia.

Scarring alopecia.


Angiokeratoma "Circumscriptum".

Angiokeratoma "Circumscriptum".


Tick bite granuloma with autoeczematization.


Guttate psoriasis.

Guttate psoriasis.


Lichen amyloidosus (primary type).

Lichen amyloidosus (primary type).


Chronic discoid lupus erythematosus, right ear; panniculitis; probable lupus erythematosus profundus, arms and trunk.


Contact dermatitis from proflavine dihydrochloride.


Treatment of alopecia areata with steroid solution.


Rheumatoid arthritis with constrictive pericarditis and diastolic murmurs.


The subhyoid median ectopic thyroid.

The subhyoid median ectopic thyroid.


Arterial punctures by pulmonary function laboratory technicians.


Nucleoside conformations. 8. Conformation of guanosine 2'-phosphate in aqueous solution by proton magnetic resonance spectroscopy.


Nuclear satellite DNAs of yeast.

Nuclear satellite DNAs of yeast.


Isolation of the intact strands of the deoxyribonucleic acid of Tphi3, a bacteriophage for Bacillus stearothermophilus.


A comparison of gel electrophoresis and density gradient centrifugation of heterogeneous nuclear RNA.


The incorporation of ( 3 H)uridine into nuclear RNA in the uterus of the rat during early pregnancy.


The effects of 17 -estradiol on the rate of synthesis of RNA in the uterus.


RNA turnover in endoplasmic reticulum-bound and free ribosomes.


Effect of amino acid starvation on ribosome formation in HeLa cells. Ribosomal labelling patterns in cells deprived of different individual amino acids.


Control of ribosome content, gamete formation and amino acid uptake in wild-type and arg-I Chlamydomonas reinhardti.


Number and activity of free and membrane-bound spleen ribosomes during the course of the immune response.


The incorporation of cysteine into an acceptor protein of human endometrium tissue.


Induction of enzymes in dormant spores of Aspergillus oryzae. 3. Effects of kanamycin and streptomycin.


In vitro biosynthesis of bone matrix in bones of rabbits intoxicated with fluoride.


Cortical bone volume and mass.

Cortical bone volume and mass.


Rate of normal longitudinal bone growth in the rat.


Answer to Dr. Frost's letter to the editor.


Elemental particles in bone and dentine.


Mechanism of oxidation of tetrahydropterins.


Reduction of folate by Ti 3+ .

Reduction of folate by Ti 3+ .


Binding of some primary aromatic amines to certain rat brain particulate fractions.


Location of the G 0 -phase in the cell cycle of the mouse haemopoietic spleen colony forming cells.


Stimulation of haemopoietic colony formation by antilymphocyte serum.


Cell kinetics of growth cartilage in the rat tibia. I. Measurements in young male rats.


Cell kinetics of growth cartilage in the rat tibia. II. Measurements during ageing.


Structure-activity correlations between hydroxamic acids and their inhibitory powers on urease activity. I. A quantitative approach to the effect of hydrophobic character of acyl residue.


Cell kinetics in diffusion chambers: survival, resumption of proliferation, and maturation rate of murine haemopoietic cells.


Studies on cyclophosphamide metabolites and their related compounds. I.


Absorption of drugs from the skeletal muscle of the rats. 4. Absorption of cationic drugs from the muscle.


Effect of bile salts on the gastrointestinal absorption of drugs. IV. Site of intestinal absorption of sodium taurocholate and its consequence on drug absorption in the rat.


Metabolic fate of 6,6,9-trimethyl-9-azabicyclo(3,3,1)non-3 -yl  , -di(2-thienyl)glycolate hydrochloride monohydrate (PG-501).


Studies on morphinan derivatives. I. The synthesis of several new 3-substituted derivatives of N-methylmorphinan having antitussive activities.


Studies on morphinan derivatives. II. The synthesis of d-3-methyl-N-methylmorphinan, a new antitussive.


Gas chromatography and its combination with mass spectrometry of urinary sugar alcohols.


Physicians' appreciation of drug charges to the patient.


Getting patients to follow advice: the art of communication.


Cystic fibrosis--survival could depend on you.


The college physician and the student.

The college physician and the student.


Evaluating performance of the physician's assistant. Otoscopic screening by nurses.


Subungual infection in the newborn. An institutional outbreak of unknown etiology, possibly due to veillonella.


Regional lymphadenitis following BCG vaccination (BCGitis). Clinical comments based upon 25 instances among 1295 childhood vaccinees.


Acute splenic sequestration crises (ASSC) in young children with sickle cell anemia. Clinical observations in 20 episodes in 14 children.


Paralytic poliomyelitis before and after mass vaccination. A record of clinical and emographic experiences in southern Iran.


An infant ill with a systemic disease and swollen gums.


Structure of synovial membrane in rheumatoid arthritis.


Experimental thyroid carcinogenesis.

Experimental thyroid carcinogenesis.


Community medicine.

Community medicine.


The medical officer of health and the other services.


Forensic odontology.

Forensic odontology.


Drug interactions.

Drug interactions.


Marriage in difficulty: the work of marriage counselling.


Uncontrolled fire: the everyday enemy.

Uncontrolled fire: the everyday enemy.


Radiation-induced life shortening in germfree mice.


Neuronal degeneration in aging and after experimental injury.


Composition, template properties and thermostability of liver chromatin from rats of various age at deproteinization by NaC1 solutions.


Composition, template activity and thermostability of the liver chromatin in rats of various age.


Aminoacylation and methylation of tRNA as a function of age in the rat.


Changes in collagen with age. 3. The isolation and partial characterization of the pre-  fragment.


Changes in the collagenous stroma in rat kidney in relation to age.


Electrical activity of the cat duodenum in fasting and vomiting.


Circular muscle electromyogram in the cat colon: local effect of sodium ricinoleate.


Lymphocyte transformation and alcoholic liver injury.


Natural history of alcoholic hepatitis. 3. Histological changes.


Eosinophilic infiltration of the gallbladder.


Biliary excretion of mercury enhanced by spironolactone.


Arteriographic diagnosis of a juvenile cecal polyp.


Giardiasis and vitamin B 12 malabsorption.


Calcium metabolism in a patient with Crohn's disease and diffuse symmetrical periostitis.


Interpretation of the acid secretory response to insulin after vagotomy.


Insulin test results should be expressed as a number, not as positive or negative.


Mechanism of hyposecretion in gastric ulcer.


Quantitative ultrastructural studies on gastric parietal cells.


Pentagastrin infusion-glycine instillation as a measure of acid absorption in the human stomach: comparison to an instilled acid load.


Unimpaired response of rabbit jejunum to cholera toxin after selective damage to villus epithelium.


Effects of bile diversion on the lipid-reesterifying capacity of the rat small bowel.


Non-dietary lipid in the intestinal lumen. Lipid in the intestinal lumen is mainly dietary in origin, but there is also an endogenous component from bile, bacteria, and the mucosa (through exudation and cell loss). Perfusion experiments in fasting rats demonstrate that exfoliated cells carry with them into the small intestinal lumen an average of 1.12 mg lipid/30 minutes; lipid classes consisting of phosphatidyl choline (lecithin), triglyceride, cholesterol, cholesterol ester, phosphatidyl ethanolamine, and free fatty acid. Fatty acid also enters the lumen independently of cells by exudation. Since the rate of lipid exfoliation and exudation considerably exceeds the faecal lipid excretion in fasting rats, efficient reabsorption must normally occur. Calculations based on published data suggest the daily exfoliation of 12 to 30 g lipid into the small intestinal lumen of fasting man. When reabsorption is impaired, especially in states of increased cell turnover, endogenous mucosal lipid may account for a significant proportion of faecal lipid, perhaps sufficient to constitute a state of fat-losing enteropathy.


Corticosteroids in liver disease: studies on the biological conversion of prednisone to prednisolone and plasma protein binding. The conversion of prednisone to the biologically active corticosteroid prednisolone and the degree of plasma protein binding of prednisolone were studied in 22 patients with acute or chronic liver disease and in eight control subjects. In patients whose disease was active at the time of study, as judged by elevated serum levels of bilirubin and transaminase, significantly higher levels of plasma prednisolone were obtained after prednisolone administration than after equivalent doses of prednisone. In addition, the amount of unbound drug in the plasma was higher in patients with active disease. There was a significant correlation between the extent of plasma protein binding of prednisolone and the serum albumin concentration. Azathioprine did not affect the plasma binding of prednisolone in vitro. The plasma half-life of prednisolone was prolonged in two of three patients with chronic liver disease studied. These results suggest that in patients with acute hepatitis or active chronic liver disease there is impairment of reduction of the 11-oxo group of prednisone, and also impaired ring A reduction of prednisolone. Thus, incomplete conversion of prednisone to prednisolone occurs, which is a necessary step for biological activity; on the other hand there is also impairment of prednisolone degradation. These, together with low serum albumin concentrations which are associated with higher levels of circulating unbound prednisolone, result in quite different levels of biologically active corticosteroids compared with equivalent doses of prednisone or prednisolone in subjects without liver disease. The findings have important practical implications for the use of corticosteroids in patients with active liver disease.


Antidepressants and liver disease.

Antidepressants and liver disease. Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed.


A comparison of Boots and GIH secretin as stimuli of pancreatic secretion in human subjects with or without chronic pancreatitis. The effects of single intravenous injections of 1 u/kg body weight Boots and 1 u/kg GIH secretin were compared in 10 male control subjects and five men with chronic pancreatitis. The duodenum was aspirated for the next hour in 4 x 10 minute and 1 x 20 minute fractions, and the volume, bicarbonate concentration, and tryptic activity were measured. The duodenal juice volume and peak bicarbonate output in response to GIH secretin 1 u/kg iv were double the responses to Boots secretin 1 u/kg, but tryptic activity was significantly less. The coefficients of variation of these measurements were not appreciably improved by expression of the results in terms of body weight. Measurements of bicarbonate concentration or enzyme output in the submaximal pancreatic function tests using Boots secretin 1 u/kg were of some use as diagnostic discriminants between normal subjects and patients with chronic pancreatitis. However, these measurements were of little value with the test using a near-maximal stimulus of 1 u/kg GIH secretin. Measurement of peak bicarbonate output is probably the best diagnostic discriminant, and discrimination is not improved by expression of the results on a body weight basis.


A new disposable probe for recording intraluminal pressure and electric potentials in the human gastrointestinal tract.


Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals. A new approach in the diagnosis of exocrine pancreatic insufficiency has been evaluated in animals. The method involves the oral administration of a chymotrypsin-labile peptide which contains p-aminobenzoic acid (PABA) as a tracer group. In the small bowel in the presence of chymotrypsin, the PABA is split from the peptide and is rapidly absorbed. The amount of PABA (as total aromatic amines) recovered in the urine during the six hours after the dose is used as an index of exocrine pancreatic function. The procedure has been shown to be reliable in detecting surgically induced pancreatic insufficiency in rats, swine, and dogs.


Fibrosing alveolitis.

Fibrosing alveolitis.


Diagnosis of interstitial pulmonary fibrosis.


Diffuse interstitial pulmonary fibrosis: course and prognosis.


Observations on percutaneous lung biopsy.


Tobacco and health.

Tobacco and health.


Chronic bronchitis amongst the mining population.


Tuberculosis control in India.

Tuberculosis control in India.


Primary prevention of chronic cor-pulmonale in India.


Mediastinal dermoid presenting with massive haemoptysis.


Instrumental perforation of the oesophagus leading to lumbar fistula.


Microfilariae detected in peripheral blood in tropical eosinophilia (a preliminary report).


The aging process.

The aging process.


An L-dopa paradox: bipolar behavioral alterations.


An appraisal of anorexiants in the treatment of obesity.


A fellowship in geriatric medicine.

A fellowship in geriatric medicine.


Therapeutic decision making and institutional advocacy in caring for the ill aged.


Massive edema induced by thioridazine (Mellaril): an unusual complication.


Complications of arthroplasty of the hip.


Chiari osteotomy for acetabular dysplasia in young subjects.


Loosening of the cemented acetabular cup in total hip replacement.


Late fracture of the acetabulum after total hip replacement.


Reduction of acutely slipped upper femoral epiphysis.


Ilo-femoral venous thrombosis after operations on the hip. A prospective controlled trial using dextran 70.


Hip assessment: a comparison of nine different methods.


Cystic angiomatosis of bone. A report of three cases and review of the literature.


Biochemical indicators of radiation damage: perspective and review.


Progressive and resolving infantile idiopathic scoliosis. The differential diagnosis.


Injuries of the tarso-metatarsal joints. Etiology, classification and results of treatment.


The natural history of the rheumatoid metacarpo-phalangeal joint.


Fractures of the neck of the radius in children. Mechanism of causation.


Capsular compliance and pressure-volume relationships in normal and arthritic knees.


Total dislocation of the ilium. Report of a case.


Isolated trabecular fatigue fractures in the femoral head.


The effect of injection of hydrocortisone into rabbit calcaneal tendons.


Effects of prednisolone on the distribution and activity of two phosphoesterases in membrane preparations from HeLa cells.


Ontogeny of the human lymphoid system: study of the cytological maturation and the incorporation of tritiated thymidine and uridine in the foetal thymus and lymph node and in the infantile thymus.


Separation of mouse spermatogenic cells by velocity sedimentation.


Combined effects of light and carbon dioxide on egg production of Indian meal moths.


Effect of polyene antibiotics on the growth and development of the house fly.


Toxicity of a series of dimethoate analogues to resistant and susceptible house flies.


Embryonic inhibition and oviposition induction in Aedes aegypti by certain terpenoids.


Parasites and predators of the face fly in east-central South Dakota.


Control of the southern cattle tick by pour-on animal systemic insecticides.


Control of three-host ticks. Laboratory tests of systemic insecticides in feed of cattle.


Juvenilizing activity of compounds related to the juvenile hormone against pupae of the stable fly.


Biology and flight ability of the house fly following irradiation of the pupae.


Separation and identification of carbofuran, its metabolites, and conjugates found in fish exposed to ring  14 C-labeled carbofuran using ITLC silica gel strips.


A facile synthesis of esters of thiocholine iodide, substrates for cholinesterase.


Citrate accumulation in twospotted spider mites, house flies, and mice following treatment with the acaricide 2-fluoro-N-methyl-N-(1-naphthyl) acetamide.


The community health clerkship: profile of a program.


The community medicine clerkship: a learner-centered program.


The decision for rural practice.

The decision for rural practice.


An approach to the construction of simulated exercise in clinical problem-solving.


Evaluating clinical skills of students in pediatrics.


Medical school admissions committee members: a descriptive study.


Predicting performance in the first year of a six-year medical school program.


Criterion-referenced evaluation of student performance.


A basic psychiatry course for medical students.


Solutions needed for medical school admissions problems.


Professional activities of physicians holding faculty appointments in U.S. medical schools, 1971.


New medical school costs.

New medical school costs.


Statistical analysis of specialty choice.


Calcium inward currents in internally perfused giant axons of Loligo forbesi.


Attitude conflict, GSR, and traditional-modern attitude change among Hong Kong Chinese.


Perception of emotion: the role of race, sex, and presentation mode.


The effects of variations in evaluativeness of traits on the relation between stimulus affect and cognitive complexity.


Empathy and communication efficiency.

Empathy and communication efficiency.


Race and sex in the communication of emotion.


Reported activation and verbal learning as a function of group size (social facilitation) and anxiety-inducing instructions.


Self-referent accuracy in self-analytic groups.


Locus of control and creativity in black and white children.


Feelings toward a frustrating agent as affected by replies to correction.


Eye contact and the human movement inkblot response.


Freeze-etching.

Freeze-etching.


Sharpening a microtome knife on the Elliott knife sharpening machine.


Apparatus for the rapid processing techniques in electron microscopy.


An inexpensive microscope lamp.

An inexpensive microscope lamp.


A thermostatic heater for preparations beneath the microscope.


Morphology and other physical characteristics of urediospores possibly related to aerodynamics and long range travel.


Studies on the antibiosis of dermatophytes.


The peripheral blood standard values in newborns in Bandung.


Studies of childhood leukemia in Surabaya, East-Java. I. Some epidemiologic observations.


Studies of childhood leukemia in Surabaja, East-Java. II. Maternal age and birth order effects.


Glucose-6-phosphate dehydrogenase deficiency.


Preparation of  125 I-labelled synthetic human gastrin I for radioimmunoanalysis.


Rat urinary pigments. Comparison with human pigments and investigation of rate of incorporation of ( 14 C)glucosamine.


Rapid determination of serum cholesterol by a modified 'Pearson method'.


Effective plasma flow of the individual kidney. Determination on the basis of the ( 131 I)hippuran renogram.


Time course of enzyme escape via heart lymph following myocardial infarction in the dog.


ST depression, heart rate, and blood pressure during arm and leg work.


Effect of pre-existing high blood lactate concentration on maximal exercise performance.


Enhancement of heme catabolism by caloric restriction in man.


Human forearm muscle metabolism during exercise. VII. FFA uptake and oxidation at different work intensities.


The effect of triamterene on plasma and extracellular fluid volume and blood pressure in ten thiazide-treated hypokalemic patients with essential hypertension.


Cold promoted activation of factor VII. II. Identification of the activator.


Cold promoted activation of factor VII. I. Evidence for the existence of an activator.


Cold promoted activation of factor VII. 3. Relation to the kallikrein system.


Cold promoted activation of factor VII. IV. Relation to the coagulation system.


Oral contraceptives and platelet function.


Differing procoagulant activities in the extracted lipids of high and low density pltelet plasma membranes.


The effect of neuraminidase on platelet aggregation induced by ADP, norepinephrine, collagen or serotonin.


Effect of lidoflazine (R 7904) on human platelet function in vitro.


Studies on fibrin formation and effects of dextran.


Structural alterations in fibrin clots with dextran.


Coagulation changes induced by endotoxin and purified contact activation product.


The effect of some synthetic arginyl and lysyl compounds on clotting and fibrinolysis.


Fibrinolysis by bile.

Fibrinolysis by bile.


Observations on factor X activity after adsorption to barium sulphate.


Plasma glucagon response to blood glucose fall, gastrointestinal hormones and arginine in man.


Different stimuli to disseminated intravascular coagulation in liver diseases.


The isolated and cross-circulated AV node preparation of the dog.


Angiographic features of submucosal tumors of the stomach.


Detection of organophosphate pesticides in blood serum from the patients suspected of acute and chronic pesticides poisonings and its clinical significance.


Typology of ephemerid chloride cells.

Typology of ephemerid chloride cells.


The distribution of ingested silver in the kidney of the rat and of the rabbit.


Hair growth in oral cavity.

Hair growth in oral cavity.


Phosphatases in the nervous tissue (the nature of the ganglionic nerve cells in the tongue).


Scanning electron microscopy of chondrocytes.


The genioglossus muscle: a reassessment of its anatomy in some mammals, including man.


The dimensions and shape of the human maxillary sinus in the perinatal period.


A study of anterior femoral curvature in Indian subjects.


Female prostate in the house rat Rattus rattus.


Comparative cytoarchitecture of the spinal cord grey matter in the pig and cat: does Rexed's schema apply to the pig?


Fibre size and conduction velocity in the vagus of the domestic fowl (Gallus domesticus).


Lymphoid aggregations in the oesophagus of the toad (Bufo melanostictus).


Masked speech audiometry in central deafness.


The physiological range of pressure difference and cupula deflections in the human semicircular canal. Theoretical considerations.


"New horizons in laryngology".

"New horizons in laryngology".


Vibratory pattern of the vocal cord in unilateral paralysis of the cricothyroid muscle. An experimental study.


General anesthesia for microlaryngoscopy using small bore endotracheal tubes.


Spontaneous healing of idiopathic facial paralysis. A clinical and electromyographic study.


Growth pattern of meningeomas penetrating the skull base.


Adenotomy, antrostomy and Caldwell-Luc operation in the treatment of chronic bronchitis in children.


The endurance of the pump.

The endurance of the pump.


[The vectorcardiogram in Duchenne's progressive muscular dystrophy].


The infant with transposition of the great arteries. I. Cardiac catheterization protocol.


The microvasculature of heart valves in rheumatic heart disease.


The vectorcardiogram and electrocardiogram in supravalvular aortic stenosis and coarctation of the aorta.


Left ventricular end-diastolic pressures following selective coronary arteriography.


The value of the ultrasonic Doppler method and apexcardiography as reference tracings in phonocardiography.


The comparative inotropic effects of six clinically used antiarrhythmic agents.


The electrocardiographic effects of elevated cerebrospinal fluid pressure: Wolff-Parkinson-White type of conduction disturbance.


The sequence of normal ventricular recovery.


Delayed coronary blood flow detected by computer analysis of serial scans.


Clinical pathologic conference: mycotic arteritis.


A sphygmomanometer in every home.

A sphygmomanometer in every home.


Bedside diagnosis of postinfarction ventricular septal defect using the hydrogen-sensitive, platinum-tipped, wire electrode.


Long-term suppression of foreign body endocarditis with cephalexin.


Regional blood sampling for assessing metabolic changes in myocardium.


Wedensky inhibition.

Wedensky inhibition.


Terminology in catheter marking.

Terminology in catheter marking.


Introduction to intestinal microecology.


Source and protective function of coproantibodies in intestinal disease.


Bacterioidaceae endotoxin detection by Limulus assay.


A prospective study of infections in penetrating abdominal trauma.


Needs for illuminating the microbiology of the lumen.


Fulminant hepatitis with coma successfully treated by plasmapheresis and hyperimmune Australia-Antibody-rich plasma.


Radiotelemetry pH determination for gastroesophageal reflux. An analysis of 521 cases.


Comparative assessment of gastric emptying by the "Barium-Burger" and saline load tests.


Mesenteric arterial disease.

Mesenteric arterial disease.


A comparative study of pentazocine and meperidine on the biliary passage pressure.


Gastrointestinal complications in neurosurgical patients treated with steroids.


The radiology corner. Duplication of the small intestine.


Bacteroides bacillemia. Sepsis for surgeons.


Carotid artery stenosis. Association with surgery for coronary artery disease.


Left colon ischemia complicating aorto-iliac reconstruction. Causes, diagnosis, management, and prevention.


Autogenous saphenous vein aortorenal grafts. A ten-year experience.


A combined technique for peripheral arterial embolectomy.


Vascular complications of drug abuse.

Vascular complications of drug abuse.


Leg edema following femoropopliteal autogenous vein bypass.


Venous and arterial occlusive disease treated by enzymatic clot lysis.


Intraoperative angiography in the immediate assessment of arterial reconstruction.


Surgical management of vascular trauma distal to the popliteal artery.


Stroke on the wrong side. Use of the Doppler ophthalmic test in cerebral vascular screening.


Optimal resources for vascular surgery.

Optimal resources for vascular surgery.


The high cost of hospital care. A seminar.


Adenylate energy charge: relation to guanylate energy charge and the adenylate kinase equilibrium constant.


Androgen uptake and binding in rat epididymal nuclei, in vivo.


Mechanism of hydroxylation of aromatic compounds. II. Evidence for the involvement of superoxide anions in enzymatic hydroxylations.


Quantitative protein sequencing using mass spectrometry: N-terminal sequence analysis of small quantities of peptides from the mass spectral analysis of the N-methylthiourea derivatives.


Stabilization of a lipid bilayer membrane by polylysine.


In vitro protein synthesis directed by RNA transcribed from vaccinia DNA.


The rate of carbon monoxide binding to hemoglobin Kansas.


Complete chemical modification of the carboxyl groups in hemerythrin: effect on the active center and subunit interactions.


High resolution proton magnetic resonance study of the two quaternary states in fully ligated hemoglobin Kansas.


The effects of ruthenium red on reactions of blowfly flight muscle mitochondria with calcium.


Some factors controlling incorporation of labile sulfur into thiol-iron(3) complexes.


Naturally occurring crystals in the potato: isolation and identification as a protein.


Thermal bleaching of rhodopsin as a two stage process.


The stimulation of liver ornithine decarboxylase by a factor from fetal calf serum.


Evidence for enhanced basement membrane synthesis and lysine hydroxylation in renal glomerulus in experimental diabetes.


Mitochondrial thymidine kinase of bromodeoxyuridine-resistant, kinase-deficient HeLa(BU25) cells.


Molecular dynamics of acetylcholine and of choline.


Effects of fatty acids on incorporation of serine into phosphatidylserine in mouse liver microsomes.


Reduced oxygen content in equilibrated fresh heparinized and ACD-stored blood from cigarette smokers.


Enzymatic isomerization of oleic acid to trans-  10 -octadecenoic acid.


Elastomers as analogues of anaesthetic receptors.


The gas chromatographic estimation of halothane in blood using electron capture detector unit.


Factors affecting plasma levels of lignocaine and prilocaine.


Anaesthesia for Caesarean section. Analysis of blood concentrations of methoxyflurane using 0.1 per cent methoxyflurane and 40 per cent oxygen.


The "bronchoflator": a new technique for bronchoscopy under general anaesthesia.


An intravenous method of anaesthesia for Caesarean section. I. Propanidid.


The influence of ketamine induction on potassium changes and fasciculations following suxamethonium.


Inspired oxygen concentrations in semiclosed circle absorber circuits with low flows of nitrous oxide and oxygen.


The effect of mild hypothermia and hyperventilation on acid-base balance in major vascular surgery.


Laryngeal reflexes in children under ketamine anaesthesia.


The use of neuroleptanalgesia during surgery for phaeochromocytoma. Reports of two cases.


Bronchospasm induced by suxamethonium. A case report.


An epidural introducer.

An epidural introducer.


Gas chromatographic determination of methoxyflurane in whole blood.


An airway for direct coupling to the anaesthetic circuit.


Hiccup during anaesthesia: a clinical observation.


The bronchofiberscope as an aid to endotracheal intubation.


Results of resuscitation following cardiac arrest.


The effects of halothane on the interactions between myocardial contractility, aortic impedance and left ventricular performance. 3. Influence of stimulation of sympathetic nerves, beta adrenergic receptors, and myocardial fibres.


The sensorineural organization of the digital skin of the raccoon.


Sciatic injection neuropathy.

Sciatic injection neuropathy. Prevention of sciatic injection neuropathy can best be accomplished by teaching that the injection should be made into the gluteal mass in the upper outer quadrant rather than the buttock, and that the needle should be introduced in a plane perpendicular to the surface of the bed when the patient is lying prone. Failing prevention, one must strive for early and correct diagnosis, especially in infants, and carry out exploration with internal and external neurolysis if there is no evidence of improvement within two to three months.


The pajaroello tick bite. The frightening folklore and the mild disease. The pajaroella tick (Ornithodoros coriaceus) has a fairly wide distribution in the coastal and mountainous areas of California and Mexico. Persons engaged in outdoor activities there, are frequently bitten. Little is written in the medical literature concerning the tick and its bite. What has been written is liberally injected with frightening folklore that sometimes results in overzealous treatment. Conservative and supportive therapy is advisable and only rarely should one have to resort to such treatment as excision of an area of tissue necrosis to prevent ulceration and prolongation of healing.


Renal tubular acidosis.

Renal tubular acidosis. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Sydney E. Salmon and Robert W. Schrier, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine. Requests for reprints should be sent to the Department of Medicine, University of California, San Francisco, San Francisco, Ca. 94122.


Multiple sclerosis: an unsolved problem.


Mycoplasmas.

Mycoplasmas.


Surgical management of gastroparesis diabeticorum.


Symptomatic lower esophageal rings--treated endoscopically.


Complications of a "Mayo enema". Treatment of resulting hypernatremia and alkalosis.


The dancing eyes of neuroblastoma.

The dancing eyes of neuroblastoma.


Discontinuation of routine smallpox vaccination.


Closing the communication gap in cancer care.


Minors and the physician. Effects of the law lowering the age of majority.


Gallop rhythm.

Gallop rhythm.


Surgical treatment of atherosclerotic lesions of the subclavian artery. Of eight patients with atherosclerotic lesions (seven occlusive, one aneurysmal) of the subclavian artery, five were operated upon because of the subclavian steal and three for severe ischemia of the hand and fingers. Removal or bypass of these lesions was uniformly successful in relieving symptoms. In most cases transcervical carotid-subclavian saphenous vein bypass graft is the treatment of choice, provided no carotid obstruction exists or, if there is obstruction, it can be dealt with at operation.


The relative merits and applicability of kinetic and fixed-incubation methods of enzyme assay in clinical enzymology.


Direct potentiometric determination of total ionic fluoride in biological fluids.


Measurement of serum ionized calcium with the ion-exchange electrode.


Manual spectrophotometric and fluorometric determination of tocopherol in cerebrospinal fluid.


Rapid method for determining ultrafiltrable calcium in serum.


Isolation and measurement of pancreatic amylase in human serum and urine.


Statistics of patient test values: application to indirect normal range and to quality control.


Studies of the stability of 18 chemical constituents of human serum.


Simple automated spectrophotometric method for assay of trypsin and chymotrypsin in duodenal juice.


Automated method for determination of serum 5'-nucleotidase activity.


Inhibition of leukocyte acid phosphatase by heparin.


Simple method for determination of urinary  -aminolevulinic acid as an index of lead exposure.


Effects of various medications on values from the HABA and BCG methods for determining albumin.


Aspartate aminotransferase (SGOT) assay in serum, with use of the AutoAnalyzer II 340 colorimeter in a conventional AutoAnalyzer I system, including dialysis.


Estimation of serum proteins by electrophoresis on cellulose acetate.


Extraction of unconjugated bilirubin from serum.


Urea therapy of sickle cell anemia.

Urea therapy of sickle cell anemia.


Furfural: exogenous precursor of certain urinary furans and possible toxicologic agent in humans.


Validity of the lecithin-sphingomyelin (L-S) ratio for amniotic fluid containing blood.


Modification in a screening test for triosephosphate isomerase deficiency.


Blood acid-base values calculated with desk-top computers.


TLC of porphyrins.

TLC of porphyrins.


The president's page.

The president's page.


Pre-operative diagnosis and localization of parathyroid gland dysfunction.


A design for a state-sponsored therapeutic program for the treatment of adolescent drug dependency.


Connecticut's requirement for reporting gonorrhea; time for a change.


Quest for a spark for united forward action.


Pseudo arrhythmias during patient monitoring.


Child-resistant medication containers to reduce pediatric drug poisonings.


Cancer of the cervix in Connecticut.

Cancer of the cervix in Connecticut.


Current concepts in scoliosis.

Current concepts in scoliosis.


Radiologic case of the month. Sickel cell anemia.


Relationship between extracellular amino acids and protein synthesis in vitro in the rat pancreas.


Fructose and D-glyceraldehyde metabolism in the isolated perfused pig liver.


Complex formation between 3-phospho-D-glyceric acid and divalent metal ions.


The mechanism of adenovirus-DNA synthesis in isolated nuclei.


Style sensitivity in children.

Style sensitivity in children.


Learning and development: a neo-Piagetian interpretation.


Changes in children's spacing behaviour with nursery school experience.


Development of sociocentrism in some Turkish villages.


The social and academic competence of children vulnerable to schizophrenia and other behavior pathologies.


Prediction of psychiatric hospitalization. II. The Hospitalization Proneness Scale: a cross-validation.


A multivariate study of attention dysfunction in schizophrenia.


Redundancy-associated deficit in schizophrenic reaction time performance.


Altered motor control in chronic alcoholics.


Intellectual sequelae of Rocky Mountain spotted fever.


On becoming hypnotized: how skeptics become convinced: a case of attitude change?


Binding of hydrogen donors by peptide groups of lactams. Identity of the interaction sites.


Deacylation of acyl chymotrypsins formed from aromatic carbonate diesters. Evidence for hindered nucleophilic attack by histidine-57.


Interactions of divalent metal ions with inorganic and nucleoside phosphates. I. Thermodynamics.


The sequence analysis of polyribonucleotides by stepwise chemical degradation. A method for the introduction of radioactive label into nucleoside fragments after cleavage.


Cysteine-catalyzed hydrogen isotope exchange at the 5 position of uridylic acid.


An active-site titrant for arylsulfate sulfohydrolase.


Metal binding by thionucleosides.

Metal binding by thionucleosides.


Epidemiology of Hodgkin's disease.

Epidemiology of Hodgkin's disease.


A comparative study of divorce in rheumatoid arthritis and other rheumatic diseases.


Serum cholesterol changes: effects of diet and regression toward the mean.


Serum uric acid in 23,923 men and gout in a subsample of 4257 men in France.


Tryptamine or tryptophyl peptides in endocrine cells of the mammalian adenohypophysis?


Phenylhydrazine as inhibitor of horseradish peroxidase for use in immunoperoxidase procedures.


An improved method for the histochemical demonstration of histamine and other compounds producing fluorophores with o-phthaldialdehyde.


Changing concepts in comprehensive health care. Comprehensive care in health programs. 3.


Inferior turbinate surgery: a new technique.


The relationship between the post-myocardial infarction syndrome and post-infarction ventricular aneurysm.


Newer approaches in the management of the pregnant unmarried adolescent.


Competence is not enough.

Competence is not enough.


Long term rehabilitation of the drug dependent person: the Odyssey House method.


Hailey-Hailey disease in a black family.


Thyroid carcinoma. A clinical study.

Thyroid carcinoma. A clinical study.


Surgical aspects of diverticulitis.

Surgical aspects of diverticulitis.


Fasting blood sugar and diabetes screening.


Comparative study of macrodantin and pyridium in controlling morbidity following surgery of the lower urinary tract.


Treatment of Parkinson's disease with Levodopa.


Malignant hyperthermia.

Malignant hyperthermia.


Update on abortion in Michigan.

Update on abortion in Michigan. To avoid some of the discomfort associated with suction curettage with intravenous analgesia and paracervical block, a 2-state ambulatory modification of the Luenbach paste method of abortion was developed.  This combines cervical softening by the transcervical instillation of 10-20 cc of mild anticeptic paste.  The vagina is packed with sterile gauze.  24 hours later, when the patient returns, the aspiration is carried out.  Usually neither local anesthetic or analgesia are required for dilatation.  The negative pressure required is only 55-60 cm instead of 70 cm.  The advantages of this technique include elimination of para-cervical block, built in antisepsis, less chance of uterine perforation, easier evacuation, and fewer resulting incompetant cervices.  A brief discussion of the legal status of abortion in Michigan is presented.


The variables for positive self-concept among southern black adolescents.


The day treatment center. A proposal for a community-based intensive treatment facility for emotionally disturbed minority group children and families.


The rights of minorities.

The rights of minorities.


Cancer of the penis. Radiation therapy or surgery.


Sickle cell anemia: a legal conspectus.

Sickle cell anemia: a legal conspectus.


Mortality in relation to occupational exposure in the asbestos industry.


Radiation decomtamination facility for the community hospital.


Sickle cell disease: experience in an industrial medical department.


Monitoring disability absence in an employee group.


Search for abnormalities of heme synthesis and sympathoadrenal activity--in workers regularly exposed to pesticides.


Pleural calcification in coal miners.

Pleural calcification in coal miners.


Gallium floride poisoning. A probable case with skin effects and neurological sequelae.


"Radiation decontamination facility for the community hospital".


Routine method for the estimation of ionic calcium activity and concentration in biological solutions.


Inexpensive constant pressure pulsatile perfusion pump.


The membrane lung.

The membrane lung.


Lord of the piles.

Lord of the piles.


Rise and fall of suicide rates in Australia: relation to sedative availability.


Suicide calls and identification of suicidal callers.


An analysis of suicide calls received by a personal emergency telephone advisory service after ten years of operation.


Experience with a membrane oxygenator for open-heart surgery in infants and children.


An appraisal of modified prefrontal leucotomy.


Congenital factor VII deficiency with cerebral haemorrhage treated with prothrombin concentrate.


Temper tantrums.

Temper tantrums.


The Rupert Willis Museum of Pathology.

The Rupert Willis Museum of Pathology.


An odd cause of squint.

An odd cause of squint.


A tomographic study of the base of the skull; technic and anatomic-pathologic correlation.


Resident's corner: thoracic radiography.


Crush injuries of the hand and fingers. I.


Endotoxin shock in infants and children.


Intestinal anastomosis.

Intestinal anastomosis.


Nymphomania--a symptom. I.

Nymphomania--a symptom. I.


Head and neck cancer; comprehensive team approach.


Medical testimony in a case of trauma and nymphomania (AKA, San Francisco cable car case), showing the cross-examination of the defendant's neuropsychiatrist by the plaintiff's lawyer. II.


Trauma and fat embolism.

Trauma and fat embolism.


Rural ambulance service: a problem and a solution.


Child abuse in schools.

Child abuse in schools.


Patient care appraisal. V. How to do it.


The potential of medical education in community medical centers.


Rapidly progressive glomerulonephritis.

Rapidly progressive glomerulonephritis.


The nurse practitioner: Idaho's experiment to improve rural health care.


Tonight and every night.

Tonight and every night.


Moving a ward.

Moving a ward.


The hospital where the babies come on time.


An insight into university health nursing.


Bromley Accident and Emergency Centre.

Bromley Accident and Emergency Centre.


Malnutrition.

Malnutrition.


A christmas angel.

A christmas angel.


A sense of guilt.

A sense of guilt.


On call.

On call.


Evaluating nutrition intervention progrmams.


An investigation on the anthracene derivatives in Rumex hydrolapathum Huds. II.


The package as a functional part of a drug distribution system.


Relationship of maximal expiratory air flow to volume and time in patients with chronic obstructive bronchitis.


A list of the Chironomidae (Diptera) known to occur in Ireland, with notes on their distribution.


Growth of Trichophyton mentagrophytes on natural substrates.


Growth on amino acids, cell wall proteins, and hydrolysis of yeast phase cell walls of Histoplasma capsulatum and H. duboisii.


The frequent isolation of Phialophora verrucosa and Phialophora pedrosoi from natural sources.


Ascospore morphology of Nannizzia and Arthroderma species by scanning electron microscopy.


Gastroduodenal mucosal changes in chronic uremia.


Hydrolysis of conjugated folic acid by pancreatic "conjugase".


The effect of x-irradiation on gastric secretion in the intact guinea-pig.


The effect of x-irradiation on the parietal cell population in the intact guinea-pig.


The short-term stability of the insulin test result after truncal and selective vagotomy for duodenal ulcer.


Albumin and immunoglobulin turnover in patients with chronic active liver disease treated with prednisone.


Response to duodenal acidification in man. IV. Effct on gastric emptying.


Gastric secretion of calcium in patients with primary hyperparathyroidism before and after removal of parathyroid adenomas.


Gastric ulcer treated with vagotomy, pyloroplasty, and excision.


Some properties of mucus in patients with gastric ulcer. Effect of treatment with carbenoxolone sodium.


Mechanism of the inhibitory action of endogenous cholecystokinin and caerulein on pentagastrin--induced gastric secretion.


Lymphocyte transformation and delayed hypersensitivity in Crohn's disease.


Sarcoidosis, hypercalcemia and hyperparathyroidism.


Insufficiency of primary treatment of pulmonary tuberculosis in relation to marriage and abuse of alcohol.


Overall and regional lung function during bronchopneumonia.


67 Ga-scintigraphy in non-malignant lung diseases.


A new Newton's law of cooling?

A new Newton's law of cooling? Several physiologists confuse Fourier's law of animal heat flow with Newton's law of cooling. A critique of this error in 1932 remained ineffective. In 1969 Molnar tested Newton's cooling law. In 1971 Strunk found Newtonian cooling unrealistic for animals. Unfortunately, he called the Fourier formulation of animal heat flow, requiring post-Newtonian observations, a "contemporary Newtonian law of cooling."


[Pancreatectomy in the eel: effects on serum glucose and cholesterol]. Pancreatectomy in the eel causes a slight tendency toward hyperglycemia; total and partial pancreatectomies cause a drop of total serum cholesterol. Thus, complete removal of the islet tissue in this teleost is not followed by diabetes mellitus, and also the endocrine control of the cholesterol-containing serum components seems to differ from that in mammals.


Evidence for active immunity to morphine in mice. The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.


A new approach in integrated control: insect juvenile hormone plus a hymenopteran parasite against the stable fly. Two insect juvenile hormone analogs, 4[(6,7-epoxy-3-ethyl-7-methyl-2-nonenyl)oxy] benzene and 6,7-epoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, when applied topically to pupae of the stable fly, Stomoxys calcitrans (L.), were morphogenetically effective against the metamorphosing pupae but did not affect oviposition and development of the hymenopteran parasite, Muscidifurax raptor Girault and Sanders, in the treated pupae. Also, reproductivity of the parent generation of parasites was not affected.


Recognition of cancer in vivo by nuclear magnetic resonance. Pulsed nuclear magnetic resonance has been used to differentiate in vivo between normal mouse tail tissue and a malignant transplanted melanoma, S91, located on the tail. The tumor displayed a nuclear (proton) spin-lattice relaxation time of approximately 0.7 second contrasted with the simultaneously measured normal tail tissue relaxation time of approximately 0.3 second.


Genital sensory field: enlargement by estrogen treatment in female rats. Recordings of neuronal activity in the pudendal, genitofemoral, and pelvic nerves indicate that the sensory fields of these three nerves are the perineum, the caudal abdomen, and the vagino-cervical area and rectum, respectively. The sensory field of the pudendal nerve was significantly larger in estrogen-treated ovariectomized female rats than in uninjected controls. This effect of estrogen was not mediated by pudendal efferents.


Neurotrophic effect on isolated chick embryo muscle in culture. Acetylcholinesterase activity in cultures of dissociated skeletal muscle prepared from the thigh muscle of the 10-day-old chick embryo was increased by the presence of innervating spinal cord explants, spinal cord explants in a parabiotic environment, and by media containing brain-spinal cord extract.


Growth hormone responses to L-dopa in depressed patients. Plasma human growth hormone responses to oral administration of 500 milligrams of L-dopa were analyzed in three groups of subjects: normals, age 20 to 32; normals, age 48 to 68; and unipolar depressed patients, age 45 to 68. While only 7 percent of the young normals had deficient human growth hormone responses to this stimulus, 36 percent of the older normals and 77 percent of the depressed patients failed to have adequate responses, suggesting an effect of age and a further effect of depressive illness. Because the release of human growth hormone appears to be closely related to brain catecholamine metabolism, the deficient responses in the depressed patients may provide further support to the concept of a neurochemical defect in depressive illness.


Habituation and dishabituation: interactions between peripheral and central nervous systems in Aplysia. The withdrawal response of the isolated siphon of Aplysia habituates to a light stimulus and dishabituates to a tactile stimulus, and vice versa, with or without connections to the central nervous system. The peripheral nervous system can dishabituate or enhance the response mediated by the central nervous system and vice versa. Normally the adaptive siphon withdrawal response of the intact animal must be mediated by the integrated activity of the peripheral and central nervous systems.


Rat origin of CHB cells.

Rat origin of CHB cells.


Termination of pregnancy in the unmarried.


The use and abuse of analgesics.

The use and abuse of analgesics.


Mathematical models and their applications in medicine.


Distortion of image due to limited range of rotation of x-ray tube in axial transverse tomography.


Effects of ethynodiol diacetate (SC 11800) on the pregnancy and mating behavior in female rats.


Aging effect of blood pantothenic acid content in female.


Interaction between adenosine compounds and norepinephrine in dog renal circulation.


Effect of tremorine and oxotremorine on the S-A node of the dog heart in vivo.


Osteoporosis prevalence and nutritional intake among the people in farm, fishing and urban districts.


Studies on reducing sugars in stools of acute infantile diarrhea, with special reference to the difference between breast-fed and artificially fed babies.


Secular changes in the Eskimo community of Augpilagtok.


Dermatoglyphics of the Micronesians from the outer islands of Yap.


Inbreeding effects in a French Canadian isolate. II. Sex ratio at birth.


In vitro studies on the uptake of biogenic amines by rat mast cells.


The effect of bilateral carotid artery ligation upon the blood flow and the energy state of the rat brain.


Effect of training on esterified fatty acids and carnitine in muscle and on lipolysis in adipose tissue in vitro.


Regulation of middle ear sound transmission in the nonanesthetized rabbit.


Production and removal of lactate during exercise in man.


Low flow states in the microvessels of skeletal muscle in cat.


Coding of amplitude and frequency modulated sounds in the cochlear nucleus of the rat.


Lipid biosynthesis from DL (2- 14 C) mevalonic acid in intact mice and rabbits.


In vitro work load and rat heart metabolism. II. Effect on amino acid transport.


Fast and slow units in extrinsic eye muscles of cat.


Catecholamines and cholinesterases in the paracervical (Frankenhäuser) ganglion of normal and pregnant rats.


Complement-fixation test for detection of viral antibodies in chicken serum. II. Immunologic response in chickens following experimental infection with Newcastle disease virus.


Some new observations on "fatty liver syndrome" in laying hens.


Structure-function relationships of various steroids relative to lipid metabolism in human blood cells.


Passive hemagglutination test in diagnosis of experimental tuberculosis in ducks, compared with other fowl.


Variations in purine phosphoribosyl transferase enzymes during growth of fibroblast cell cultures.


Replication of a herpesvirus from turkeys (HVT) in hamster kidney cell cultures after infection with a cell-free preparation.


Microestimation of tryptophan in palsma by a flourometric procedure.


Alpha-galactosidic configuration in ceramide trihexoside synthesized by rat spleen homogenate.


The estimation of glutarate in urine using gas chromatography mass spectrometry with an internal isotopic standard.


Malignant lymphoid neoplasia in a peahen (Pavo cristatus).


Mycotic spondylitis involving the first thoracic vertebra in chickens.


Avian infectious bronchitis virus: serologic response of chickens to seven beta-propiolactone-inactivated strains.


A new automated procedure for the colorimetric determination of glucose.


Erythrocyte pyruvate kinase in experimental diabetes.


Serologic studies of type II leukosis (Marek's) infection in susceptible (S-line) and resistant (K-line) strains of chicken by indirect hemagglutination test.


Replacement of glass wool pledgets with polyurethane filters for alumina column preparation in catecholamine analysis.


High resolution analysis of hemoglobins: polyacrylamide isoelectric focusing.


Measurement of aromatic L-amino acid decarboxylase--a technical comment.


Loop accessibility in transfer RNA.

Loop accessibility in transfer RNA.


Possible outbreaks of fusariotoxicosis in avians.


Permanent arbitrators for Ontario's hospital contract disputes.


Functions of the hospital infection control committee.


The duties of the infection control officer.


A guide for handling hospital infections.


Computerized surveillance of hospital infections.


The law and the coffee break.

The law and the coffee break.


Financial controls to department heads: responsibility accounting.


Ingredient rooms--their use and design.

Ingredient rooms--their use and design.


Holography of red cells moving toward an orifice: verification of a model.


A critical evaluation of force-velocity analyses.


Tumours of bone.

Tumours of bone.


Flextime in East Birmingham.

Flextime in East Birmingham.


Care of the dying. 3. The right time to die.


Milieu therapy in a child psychiatry unit.


Nursing care study: Apert's syndrome.

Nursing care study: Apert's syndrome.


Headache.

Headache.


A gown for all reasons.

A gown for all reasons.


Ergotamine tartrate in migraine and the dangers of overdose.


Briggs: educating the nurse and midwife of the future.


Off sick--who? where and why?

Off sick--who? where and why?


Domiciliary midwives and birth control advice 1970/71. 2.


Reorganization of water services.

Reorganization of water services.


Future x-ray departments.

Future x-ray departments.


Re-orientation for 1974.

Re-orientation for 1974.


Cervical cancer screening programmes and voluntary support.


Geographical pathology and the potential prevention of cancer.


Early discharge from hospital--the consultant surgeon's point of view.


The control and eradication of animal disease communicable to man.


Rabies--the Waterhouse report.

Rabies--the Waterhouse report.


Controls and procedures for the importation of meat.


Pharmacy in the new health service.

Pharmacy in the new health service.


The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives.


The control of medicine in hospitals.

The control of medicine in hospitals.


Pituitary gonadotrophic and ovarian function in women treated with clomiphene citrate.


An evaluation of the double isotope test in the diagnosis of pernicious anaemia.


Aspects of occupational health in the petro-chemical industry.


Occupational health nursing in Scotland.


Atmospheric pollution from metallurgical and allied processes.


Investigations into the biological effects of organo-phosphorus compounds.


An unusual "epidemic" in a clothing factory.


Incorporation of reserpine into isolated rat peritoneal mast cells and mast cell granules in vitro.


Comparison of the effect of different types of exercise on the baroreflex regulation of heart rate.


The effects of hypoxia, hypercapnia, and asphyxia on the baroreceptor-cardiac reflex at rest and during exercise in man.


Pulmonary hypertension during systemic hypotension. Effects of oxygen breathing and of vasodilators.


Response to submaximal and maximal exercise at different levels of carboxyhemoglobin.


Effect of adrenaline on amino acid transport in perfused rat heart.


Cerebral energy state and cerebral venous PO 2  in experimental hypotension caused by bleeding.


The effect of bilateral carotid artery ligation upon acid-base parameters and substrate levels in the rat brain.


Choline acetyltransferase in salivary glands after surgical and chemical sympathectomy.


A paradoxical EEG response during combined hypoxemia and unilateral carotid artery ligation in the rat.


Comparison between the membrane phases of the catecholamine storage vesicles from the adrenal medulla and the sympathetic nerve trunk.


Primary chromoblastomycosis of the nasal septum.


Rapid colorimetric determination of calcium in biologic fluids with methylthymol blue.


The in vitro effect of heparin on the activated partial thromboplastin time.


Chronic hemolytic anemia associated with erythrocyte enolase deficiency exacerbated by ingestion of nitrofurantoin.


The use of laboratory determinations in the control of streptokinase therapy.


Separation of globin chains by rapid cellulose acetate electrophoresis.


Childhood variant of Niemann-Pick disease: report of a case with biochemical, histochemical, and electron microscopic observations.


Various kinds of radiation used in medical diagnosis.


On the use of x-rays and ultrasound in locating the placenta.


Serum uric acid in late pregnancy in normal and toxaemic patients. Comparison with the variations in the oxytocinase, oestriol, alkaline phosphatase and heat-stable alkaline phosphatase values.


Ultrasonic tomography of the ovaries.

Ultrasonic tomography of the ovaries.


Cathetron and radium in the treatment of functional uterine bleeding.


Amputation and closure of the bronchus.

Amputation and closure of the bronchus.


Prognosis of renal adenocarcinoma in a central hospital.


[Effect of growth hormone, thyrotrophic hormone and cortisone on the healing of full-thickness defects of the articular cartilage in rats].


Presacral liposarcoma.

Presacral liposarcoma.


Drug prescribing and use in an American community.


The medical chief residency in university hospitals.


Bone healing in multiple myeloma with melphalan chemotherapy.


Tuberculous peritonitis. Prospective study of 32 cases in Iran.


The prevalence of rheumatoid arthritis. Follow-up evaluation of the effect of criteria on rates in Sudbury, Massachusetts.


Progressive disseminated histoplasmosis. A prospective study of 26 patients.


Mortality from coronary heart disease during phenformin therapy.


Systemic amyloidosis, functional coronary insufficiency, and autonomic impairment.


Pure red cell anemia: immunosuppressive treatment.


Association of gastric carcinoma with idiopathic late-onset immunoglobulin deficiency.


Aeromonas hydrophila in clinical bacteriologic specimens.


Neurological manifestations in sickle-cell disease, with a review of the literature and emphasis on the prevalence of hemiplegia.


Training of the internist as a primary physician.


The primary prevention of atherosclerotic disease: a report of the Inter-Society Commission for Heart Disease Resources.


Lead poisoning from glazes.

Lead poisoning from glazes.


Hay fever therapy.

Hay fever therapy.


Metformin and B 12  malabsorption.

Metformin and B 12  malabsorption.


Adrenal adenoma and hypertension.

Adrenal adenoma and hypertension.


Arrhythmias after infarction.

Arrhythmias after infarction.


Bacterial risk in staging splenectomy.

Bacterial risk in staging splenectomy.


P and the null hypothesis.

P and the null hypothesis.


Premonitory hypercalcemia in leukemia.

Premonitory hypercalcemia in leukemia.


More medical education.

More medical education.


Degradation of 5-pregnene-3 , 20 -diol by a Nocardia sp. Some factors influencing the production of pregnendiol-secoacid.


Trehalase from Sclerotinia sclerotiorum.


Methyl-1-methyl-3,4-dihydro- -carboline-3-carboxylate as a new chromogenic substrate for  -chymotrypsin.


The effect of indole acetic acid on RNA polymerase in vitro.


Circadian rhythms in the phosphorylation of rat liver histones and similar basic proteins.


An estimate of intraproteic electrostatic fields values originated by the peptide groups in  -chymotrypsin.


Peptide aldehydes inhibiting chymotrypsin.


Light dependent formation of  -aminolevulinic acid in etiolated leaves of higher plants.


Comparative analysis of zymogen granule membrane polypeptides.


Hydrocarbon-coated sepharoses. Use in the purification of glycogen phosphorylase.


3 H-dTTP incorporating activities in isolated rat liver nuclei.


31 P-NMR studies of the release of diphospholygeric acid on carbon monoxide binding to hemoglobin.


The binding site for oxaloacetate on succinate dehydrogenase.


Chemical synthesis of two deoxyribopolynucleotide fragments containing the natural sequence of T4 lysozyme gene e.


Carboxyl group modification and amide assignments in automated sequencing of proteins.


Raphanatin, an unusual purine derivative and a metabolite of zeatin.


Regulation of citrate lyase activity in Rhodopseudomonas gelatinosa.


Gene amplification in mammary gland at differentiation.


Cortexolone: binding to glucocorticoid receptors in rat thymocytes and mechanism of its antiglucocorticoid action.


Isolation of viral RNA using cesium chloride-ethidium bromide equilibrium sedimentation.


Use of affinity chromatography for acetylcholine receptor purification.


Human mannosidosis--the enzyme defect.

Human mannosidosis--the enzyme defect.


The effect of general anaesthetics on active cation transport in human erythrocytes.


On the temperature dependence of initial velocities of glucose transport in the human red blood cell.


Rejection criteria for the asymmetric carrier and their application to glucose transport in the human red blood cell.


Structure and reflection spectra of chlorophyll-lipid membranes.


Support for the existence of an active transport mechanism of fructose in the rat.


An example of mutual competition between transport inhibitors of different kinetic type: the inhibition of intestinal transport of glucalogues by phloretin and phlorizin.


Anion effects on glycine entry into pigeon red blood cells.


Studies on biotransformation of elastase. I. Transport of  131 I-labeled elastase across rat intestine in vitro.


The trypsin-catalyzed hydrolysis of monomolecular films of lysylphosphatidylglycerol.


The occurrence of vitamin A in biological membranes.


An approach to the selection of membrane mutants of Staphylococcus aureus based on pH sensitivity.


Mechanism of bitter taste reception: interaction of bitter compounds with monolayers of lipids from bovine circumvallate papillae.


Isolation of acetylcholine receptors by chloroform--methanol extraction: artifacts arising in use of Sephadex LH-20 columns.


Energy transfer in black lipid membranes.


Evidence for an electrogenic ion pump in Nitella translucens. I. The effects of pH, K + , Na + , light and temperature on the membrane potential and resistance.


Child psychiatry. Services for one million children? A critical overview of recent surveys on emotionally disturbed children and youth.


Sex differences in the performance of school children.


Manic depressive disease in childhood. A case report.


The effects on the family of the presence of a mentally retarded child.


A comparison of the residential treatment response of Children's Aid Society wards and non-wards.


The residential treatment response of disturbed children using serial ratings of adjustment.


The relationship of illness and non-illness variables to the administration of ECT.


Marijuana and suggestibility.

Marijuana and suggestibility.


Koro in a French Canadian.

Koro in a French Canadian.


The metabolism of saccharin and the related compounds in rats and guinea pigs.


Studies on synthetic sweetening agents. XVII. Metabolism of sodium cyclamate. (6). Influences of neomycin and sulfaguanidine on metabolism of sodium cyclamate.


Gas chromatography of urinary anthranilic acid and 3-hydroxyanthranilic acid by solvent extraction method.


Naproxen oral absorption characteristics.


Antitumor activity of Bacillus natto. 3. Isolation and characterization of a cytolytic substance on Ehrlich ascites carcinoma cells in the culture medium of Bacillus natto KMD 1126.


Effect of plasma pH on stability and capacity of aggregation of platelets.


Biotransformation of (+)-reticuline in rat.


Hydrosoluble complexes of sterols, sterol esters and their precursors from Zea mays L.


Purification and partial characterisation of rat-liver nuclear DNA polymerase.


Polyribosome-bound and free-cytoplasmic-hemoglobin-messenger RNA in differentiating avian erythroblasts.


Oligonucleotide conformations. Optical studies on GpU analogues with modified-uridine residues.


Conformation of lysozyme in aqueous solution. Effect of ionic strength and protein concentration.


Reconstitution of Q  replicase lacking subunit   with protein-synthesis-interference factor i.


Functional properties of native and reconstituted hemoglobins from Chironomus thummi thummi.


Regulation of D-triokinase and NAD-linked glycerol-dehydrogenase activities in rat liver.


An unusual group of lysine-rich histones from gonads of a sea cucumber, Holothuria tubulosa.


Regulation of a catabolic pathway. Lysine degradation in Pseudomonas putida.


The use of glucosamine as a metabolic probe in the rat diaphragm. The effect of insulin on its metabolic fate.


Thermochemistry of lysozyme-inhibitor binding.


Distribution of immunoglobulin determinants and antigen receptors on the surface of rabbit lymphoid cells as shown by peroxidase-labelled antibody and cell rosetting techniques.


Effects of cyclophosphamide on lymphoid tissues labelled with 5-iodo-2-deoxyuridine- 125 I and  51 Cr.


Effect of viable and non-viable measles virus on proliferating human lymphocytes.


A kit for the production and fast isolation of medically useful fluorine-18.


Intravenous hemodialysis. Preliminary report.


Direct readout of bone mineral content using radionuclide absorptiometry.


Sensitivity of x-ray fluorescence for trace element determinations in biological tissues.


Experiences with a silastic spigot as a replacement for the urinary sphincters in neurogenic bladder. A preliminary report.


Proliferative and lymphoid reactions in bladder cancer.


The effect of incomplete chronic obstruction on the ureteric muscle of the dog. A quantitative study.


Selective determination of free urinary formaldehyde after oral dosage with methenamine mandelate.


A transplantable human bladder cancer in the unconditioned Syrian hamster.


Energy loss during micturition.

Energy loss during micturition.


More on prestige and respect.

More on prestige and respect.


Functional aspects of compensatory renal growth after ischemic injury.


The use of plastic spinal plates for internal fixation of the canine spine.


A standard technique for canine cerebral angiography.


Canine heartworm disease in southeastern Michigan.


Tetralogy of Fallot in a cat.

Tetralogy of Fallot in a cat.


Hematologic values of normal Basenji dogs.


Laryngeal hemiplegia following jugular injury.


Studies of the acetate kinase-phosphotransacetylase and the butanediol-forming systems in Aerobacter aerogenes. Mutants of Aerobacter aerogenes devoid of acetate kinase and phosphotransacetylase activities were isolated by selection for resistance to fluoroacetate on lactate medium. The mutants were used to study the role of the acetate kinase-phosphotransacetylase system in growth on acetate and glucose. Acetate kinase-negative and phosphotransacetylase-negative mutants were unable to grow on acetate minimal medium. Their growth rates on glucose minimal medium were identical with that of the parent strain under aerobic conditions, but lower growth rates were observed in the mutant strains during anaerobic growth on glucose medium. The mutants were unable to incorporate [2-(14)C]-acetate rapidly while growing on glycerol. Variations in acetate kinase and phosphotransacetylase levels during growth on glucose were studied. The specific activities of the enzymes increased approximately fivefold during aerobic growth on glucose in batch culture. The enzyme levels were also studied during anaerobic growth on glucose at constant pH (pH 5.8 and 7.0). Smaller increases in specific activities were found under these conditions. The role of acetate in the induction of the diacetyl (acetoin) reductase was investigated using a mutant deficient in both acetate kinase and phosphotransacetylase. The effect of pH on the induction of this enzyme during growth on glucose under anaerobic conditions was tested. The data support the idea that free acetic acid is the inducer for the enzymes of the butanediol-forming pathway in A. aerogenes.


Metabolism of gentiobiose in Aerobacter aerogenes. Cleavage of gentiobiose in cell extracts of gentiobiose-grown Aerobacter aerogenes was dependent on the presence of adenosine 5'-triphosphate (ATP). The enzymes that participate in the overall reaction were shown to be a beta-glucoside kinase, which catalyzes the phosphorylation of gentiobiose with ATP to form gentiobiose monophosphate [6-O-phosphoryl-beta-d-glucopyranosyl-(1 --> 6)-d-glucose], and a phospho-beta-glucosidase, which catalyzes the hydrolytic cleavage of gentiobiose monophosphate to form equimolar amounts of d-glucose and d-glucose 6-phosphate. Although the beta-glucoside kinase was previously shown to catalyze the phosphorylation of many beta-glucosides that serve as growth substrates (i.e., gentiobiose, cellobiose, cellobiitol, salicin, arbutin, methyl beta-d-glucoside, and phenyl beta-d-glucoside), mutant analysis and induction studies indicate that it functions only in the metabolism of gentiobiose, cellobiose, and cellobiitol.


Nonfunctional tricarboxylic acid cycle and the mechanism of glutamate biosynthesis in Acetobacter suboxydans. Acetobacter suboxydans does not contain an active tricarboxylic acid cycle, yet two pathways have been suggested for glutamate synthesis from acetate catalyzed by cell extracts: a partial tricarboxylic acid cycle following an initial condensation of oxalacetate and acetyl coenzyme A. and the citramalate-mesaconate pathway following an initial condensation of pyruvate and acetyl coenzyme A. To determine which pathway functions in growing cells, acetate-1-(14)C was added to a culture growing in minimal medium. After growth had ceased, cells were recovered and fractionated. Radioactive glutamate was isolated from the cellular protein fraction, and the position of the radioactive label was determined. Decarboxylation of the C5 carbon removed 100% of the radioactivity found in the purified glutamate fraction. These experiments establish that growing cells synthesize glutamate via a partial tricarboxylic acid cycle. Aspartate isolated from these hydrolysates was not radioactive, thus providing further evidence for the lack of a complete tricarboxylic acid cycle. When cell extracts were analyzed, activity of all tricarboxylic acid cycle enzymes, except succinate dehydrogenase, was demonstrated.


Isolation of 4'-hydroxyechinenone from Micrococcus roseus. The carotenoid 4'-hydroxyechinenone (4'-hydroxy-beta, beta-carotene-4-one) was isolated from Micrococcus roseus. It is proposed as an intermediate between echinenone and canthaxanthin.


Phospholipid composition and metabolism of Micrococcus denitrificans. The phospholipid composition of Micrococcus denitrificans was unusual in that phosphatidyl choline (PC) was a major phospholipid (30.9%). Other phospholipids were phosphatidyl glycerol (PG, 52.4%), phosphatidyl ethanolamine (PE, 5.8%), an unknown phospholipid (5.3%), cardiolipin (CL, 3.2%), phosphatidyl dimethylethanolamine (PDME, 0.9%), phosphatidyl monomethylethanolamine (PMME, 0.6%), phosphatidyl serine (PS, 0.5%), and phosphatidic acid (0.4%). Kinetics of (32)P incorporation suggested that PC was formed by the successive methylations of PE. Pulse-chase experiments with pulses of (32)P or acetate-1-(14)C to exponentially growing cells showed loss of isotopes from PMME, PDME, PS, and CL with biphasic kinetics suggesting the same type of multiple pools of these lipids as proposed in other bacteria. The major phospholipids, PC, PG, and PE, were metabolically stable under these conditions. The fatty acids isolated from the complex lipids were also unusual in being a simple mixture of seven fatty acids with oleic acid representing 86% of the total. Few free fatty acids and no non-extractable fatty acids associated with the cell wall or membrane were found.


Evidence for vectorial phosphorylation of D-fructose by intact cells of Aerobacter aerogenes. Extracellular d-fructose was metabolized preferentially over intracellular d-fructose in growing cells of a d-fructokinaseless mutant of Aerobacter aerogenes. This finding is interpreted to indicate that phosphorylation of d-fructose by the membrane-bound phosphoenolpyruvate: d-fructose 1-phosphotransferase system in intact cells is coupled to unidirectional transport.


Scanning electron microscopy of ascospores of Schwanniomyces. Ascospores of the four recognized species of Schwanniomyces were examined by scanning electron microscopy. Spores of S. alluvius, S. castellii, and S. occidentalis, which were essentially identical, had abundant, long protuberances and wide, thin equatorial rings. The two known strains of S. persoonii differed from the other species as well as from each other. One strain had spores with a wide ring but only a few short protuberances; spores from the second strain were covered with craterlike depressions and had a narrow ring. Also examined were spores of Schwanniomyces hominis (=Saccharomyces rosei) which lacked a ring and were covered with short irregularly shaped protuberances, a finding consistent with the morphology of spores from other strains of S. rosei.


Observations on ectodesmata and the virus infection process.


Intracellular distribution of amines and calcitonin in the sheep thyroid gland.


Ultrasonic cleaning of diamond knives.

Ultrasonic cleaning of diamond knives.


Microfibrils in the cytoplasm of fertile hyphae of the imperfect fungus, Drechslera sorokiniana.


Thyroid hormones in liver.

Thyroid hormones in liver.


Thyroid and the heart.

Thyroid and the heart.


Anticoagulants in thromboembolism.

Anticoagulants in thromboembolism.


Adoption.

Adoption.


The use of anticoagulants in the prevention of venous thrombosis after myocardial infarction.


Duration of anticoagulant therapy in venous thrombo--embolism.


The pensioner hearing aid scheme: a survey in South Australia.


The changing pattern of carcinoma of the cervix uteri Tasmania.


Spontaneous ascent of infection from bladder to kidney in pregnancy.


A new approach to dental anaesthesia.

A new approach to dental anaesthesia.


A new form of sensory precipitation epilepsy: epilepsy precipitated by undressing.


The partial denture--a dangerous foreign body.


A problem when ampoules are opened.

A problem when ampoules are opened.


Self-help via community health centres.

Self-help via community health centres.


Self-help for health in our environment.


Vitamin B12, folic acid, and the care of mentally disturbed aged patients.


Effects of manpower utilization on cost and productivity of a neighborhood health center.


Medical evaluation and management of osteoarthritis of the hip.


Takayasu's aortitis, 1972.

Takayasu's aortitis, 1972.


Orthopedic problems seen in exercise programs.


The bradycardia-tachycardia syndrome: an indication for transvenous pacing.


National health insurance.

National health insurance.


Diagnosis and management of parathyroid disorders.


Fractures in brittle bone diseases.

Fractures in brittle bone diseases.


The pathology of chemically-sterilized human heart valve allografts.


A scanning electron microscopy study of human heart valve allografts.


A juxtaglomerular cell tumour: light and electron microscopic studies of a renin-secreting kidney tumour containing both juxtaglomerular cells and mast cells.


Papillary necrosis in the Gunn rat: rapid induction by analgesics.


Changes in guinea-pig lungs following the inhalation of powdered egg albumen.


The release of drugs from hard gelatin capsules.


An investigation of the anthracene derivatives in Rumex hydrolapathum Huds. I.


The role of a clinically trained pharmacist in relation to future developments in health care.


The upper limit of autoregulation of cerebral blood flow--on the pathogenesis of hypertensive encepholopathy.


Ten-year mortality and morbidity related to serum cholesterol. A follow-up of 3.751 men aged 40-49.


Intracellular pH of the brain in arterial hypoxemia, evaluated with the CO 2  method and from the creatine phosphokinase equilibrium.


Brain energy metabolism in hypoxemia.

Brain energy metabolism in hypoxemia.


Heart lymph flow and aspartate aminotransferase activity after infusion of thrombin and tranexamic acid in the dog.


Aspartate aminotransferase activity in dog heart lymph after myocardial infarction.


A simple system for displaying ECG and heart rate, recorded by portable tape recorders.


The significance of the plantar ischemia test in the clinical diagnosis of peripheral arterial disease.


Plasma catecholamines in hypertension.

Plasma catecholamines in hypertension.


Differences in sizes of red and white muscle fibres in vastus lateralis of musculus quadriceps femoris of normal individuals and athletes. Relation to physical performance.


The use of a calcium infusion test in the diagnosis of hyperparathyroidism.


On the cause and degree of intraindividual serum calcium variability.


Activity of  -amylase and  -1,4-glucosidase in human liver tissue.


Is electrophoretic analysis of plasma proteins becoming out-dated?


The effect of hypercapnia upon the energy metabolism of the brain during arterial hypoxemia.


The effect of sustained hyperammonemia upon the metabolic state of the brain.


Brain capillary permeability to proteins during acute exposure to hypoxia and to carbon monoxide.