Alteration of the phospholipid composition of Staphylococcus aureus cultured in medium containing NaCl.


The activity of the different carnitine acyltransferases in the liver of clofibrate-fed rats.


Evidence for a new phospholipid intermediate in rat liver subcellular systems.


Effect of prostaglandin E 1  and norepinephrine on lipid and glucose metabolism in isolated perfused rat liver overloaded with a lipid substrate.


Metabolism of steroid hormones by schistosomes.


Effect of chlorophyllase treatment of photooxidation of P700 in chloroplast fragments.


Role of the reductive carboxylic acid cycle in a photosynthetic bacterium lacking ribulose I,5-diphosphate carboxylase.


Distribution of permeant cations in rat liver mitochondria under steady-state conditions.


Light emission from the Scenedesmus obliquus wild type, mutant 8, and mutant II strains, measured under steady-state conditions between 4 nanoseconds and 20 seconds.


Ketogenesis in isolated rat liver mitochondria. I. Relationships with the citric acid cycle and with the mitochondrial energy state.


The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage.


Co-crystallization analysis: a short method for identification and quantitative determination of DMPEA and other biological compounds.


Treatment of status asthmaticus.

Treatment of status asthmaticus.


Oncological centres.

Oncological centres.


Hodgkin's disease: a clue or a fluke?

Hodgkin's disease: a clue or a fluke?


Ischemia of the gastrointestinal tract.

Ischemia of the gastrointestinal tract.


Corticosteroids in pulmonary aspergillosis.


An assessment of postoperative outpatient cases. A total of 100 outpatients in the North-East of Scotland were given a simple anaesthetic of propanidid, nitrous oxide, oxygen, and halothane. The study was undertaken to assess what happened to patients when they left hospital after outpatient surgery. An outpatient questionnaire was used, and results show that 31% of patients journeyed home unaccompanied by a responsible person, 73% of car owners drove within 24 hours of the operation, and 9% drove themselves home. Postoperative symptoms of drowsiness (26%), headache (27%), nausea (22%), and dizziness (11%) were recorded, and a higher incidence of symptoms was recorded when surgery exceeded 15 minutes. A new form for outpatient operative procedures in Aberdeen has been devised with modern legal implications in mind.


Thiocyanate metabolism in human vitamin B12 deficiency. Patients with subacute combined degeneration who smoked had significantly lowered plasma thiocyanate levels than control smokers, but plasma thiocyanate levels in non-smoking patients with neurological disease due to vitamin B(12) deficiency were not significantly different from control values. The results provide no support for the hypothesis that chronic cyanide intoxication is responsible for the occurrence of neurological disease in a minority of patients with vitamin B(12) deficiency, although they do not conclusively exclude this possibility. The association between smoking and subacute combined degeneration of the cord has been confirmed in this study but it remains unexplained.


Long-term effects of hydroxyurea in psoriases. Hydroxyurea is an effective treatment for psoriasis but consistently produces macrocytosis in peripheral blood with a fall in haemoglobin levels and white cell counts. In this long-term study of 16 patients anaemia and leukopenia have proved frequent and troublesome side effects requiring discontinuance of treatment in many cases. In view of these findings hydroxyurea cannot be recommended as the drug of first choice even for treating severe and intractable psoriasis, and it is our opinion that methotrexate is safer and at least as effective in these circumstances. The clearest indications for the use of hydroxyurea appear to be in life-ruining psoriasis when methotrexate treatment has either failed or is contraindicated because of liver damage. A great deal more investigative work is required before these indications can be generally extended.


Anaesthesia in sickle-cell states: a plea for simplicity. 505 patients with various haemoglobinopathies were given a general anaesthetic between January 1970 and February 1972. One patient with haemoglobin SC disease and one patient with sickle-cell trait (HbAS) died postoperatively. Four other patients who were sickling positive, but whose genotypes were unknown, died, one from sickle-cell crisis precipitated by haemorrhage.A simple anaesthetic technique together with good postoperative care can provide safe general anaesthesia for patients with sickle-cell states. A plea is made for simplicity in the anaesthetic management of these patients.


Surgical aspects of bacterial endocarditis. Forty patients with a previous history of bacterial endocarditis were treated surgically between December 1967 and August 1971. Of 28 patients who had elective valve replacements there were four hospital deaths and one late death. Seven patients underwent emergency operation for intractable heart failure before completion of antibiotic treatment, six survived operation and there was one late death. Six patients had operations for infection on pre-existing valve substitutes, of whom three were treated as emergencies. There were two hospital and no late deaths. 78% of all patients were alive and well four years to nine months after operation.These results confirm that in addition to elective valve replacement surgery has an important role both in the treatment of intractable heart failure during the infective stage of bacterial endocarditis and in the eradication of infection on cardiac prostheses.


Impressions of Cogwheel. A divisional study.


Biomedical engineering at King's.

Biomedical engineering at King's.


Staffing of casualty departments.

Staffing of casualty departments.


Amniotic-membrane rupturer.

Amniotic-membrane rupturer.


Alcoholic cirrhosis of the liver.

Alcoholic cirrhosis of the liver.


Unusual bullet embolus.

Unusual bullet embolus.


Infections in hospital.

Infections in hospital.


Fibrocystic disease of pancreas and Crohn's disease.


Pancreatitis and basal emphysema.

Pancreatitis and basal emphysema.


General practice observed.

General practice observed.


Oral contraceptives and serum amylase.

Oral contraceptives and serum amylase.


Suicide rate.

Suicide rate.


Aspirin and haematemesis in children.

Aspirin and haematemesis in children.


Anesthesia by acupuncture.

Anesthesia by acupuncture.


Climate and chest disorders.

Climate and chest disorders.


Children in hospital in Wales.

Children in hospital in Wales.


Apple allergy.

Apple allergy.


Enuresis: a descriptive analysis and a controlled trial.


Cerebral angiography in children and adults with mental retardation. II. Mentally retarded group.


The place of surgery in the treatment of epilepsy in childhood and adolescence: a preliminary report in 13 cases.


Cogan's congenital ocular motor apraxia in two successive generations.


Cerebral palsy and physical fitness.

Cerebral palsy and physical fitness.


Pelizaeus-Merzbacher disease.

Pelizaeus-Merzbacher disease.


The management of chronic subdural effusion in infancy.


Cerebral oedema.

Cerebral oedema.


Letters to the editor: prognosis for infants of very low birthweight.


A blind child.

A blind child.


The effect of pH changes and ionization on the action of epinephrine upon the isolated rabbit ileum.


Sex as a factor influencing the responsiveness of arterioles to catecholamines.


Effect of different alcohols on the contractile force of the isolated guinea-pig myocardium.


Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats.


Effects of spreading depression on the turnover of cerebral dopamine.


The effects of temperature on responses of the isolated perfused heart of the guinea pig to catecholamines: a separation of the rate and force responses.


Stimulation-induced release of norepinephrine from rat superior cervical ganglia in vitro.


Inhibition of noradrenaline uptake 2  in the isolated rat heart by steroids, clonidine and methoxylated phenylethylamines.


The effects of vasodilating drugs and vasoconstrictor nerve stimulation on oxygen uptake in skeletal muscle.


The effect of  -methyl-p-tyrosine and substantia nigra lesions on spinal motor activity in the rat.


Changes in amphetamine sensitivity following frontal cortical damage in rats and mice.


Operant behavior and catecholamine-containing neurons: prolonged increase in lever-pressing after 6-hydroxydopamine.


Potentiating effect of d-INPEA on prostaglandin (PGF 2   and PGE 2 )-evoked contractions of the isolated rat uterus.


Effects of (-)-  9 -trans-tetrahydrocannabinol on regional blood flow in anesthetized dogs.


Spontaneous recovery of central respiratory function after an irreversible AChE inhibitor.


Problems and future of pediatrics in pre-industrial countries: Asia.


Problems and future of paediatrics in pre-industrial countries: Africa.


Growth and adaptation of pediatrics.

Growth and adaptation of pediatrics.


The teaching of paediatrics in developing and developed countries.


This was paediatrics of my time.

This was paediatrics of my time.


New urban families. Workshop on nutrition, Vienna 1971.


Voluntary hyperventilation as a cause of needless drowning.


Interactions at adrenergic nerve endings.


Successful treatment of a heroin addict with propranolol: implications for opiate addiction, treatment and research.


Study of maternal mortality.

Study of maternal mortality.


Fibular bone grafting in non-union of the humerus.


Hepatitis and Australia antigen.

Hepatitis and Australia antigen.


Kentucky state health department rubella immunization statistics. Errors and a proposal for alleviating these inaccuracies.


Post streptococcal diseases. I. Acute rheumatic fever.


Obscenity--a semi-science.

Obscenity--a semi-science.


R. v Hosein and Hosein.

R. v Hosein and Hosein.


Do general physicians need it?

Do general physicians need it?


Be practical about group practice.

Be practical about group practice.


Blunt thoracic trauma.

Blunt thoracic trauma.


Computer treatment planning in radiation therapy.


Using colon bypass for squamous cell carcinoma of the thoracic esophagus.


Medullo-spinal decompression and fusion for atlanto-axial dislocation due to hydroplastic separate odontoid.


Infective endocarditis. Part II.

Infective endocarditis. Part II.


The pattern and mechanisms of response to oxygen by the ductus arteriosus and umbilical artery.


Amino acid transport pathways in the small intestine of the neonatal rat.


Prenatal Niemann-Pick disease: biochemical and histologic examination of a 19-gestational week fetus.


Lewis and ABH substances in amniotic fluid obtained by amniocentesis.


Renal reabsorption of bicarbonate in puppies: effect of extracellular volume contraction on the renal threshold for bicarbonate.


Development of myocardial sympathetic innervation in the fetal lamb.


Methylmalonyl coenzyme A racemase defect: another cause of methylmalonic aciduria.


Decreased glutathione peroxidase in neonatal erythrocytes: lack of relation to hydrogen peroxide metabolism.


Safety and toxicity of dietary organic arsenicals relative to performance of young turkeys. I. Arsanilic acid and sodium arsanilate.


Light intensity and reproduction of turkey hens.


Effect of p,p'-DDT, o,p'-DDT and p,p'-DDE on the reproductive performance of caged White Leghorns.


Dietary p,p'-DDT, o,p'-DDT or p,p'-DDE and changes in egg shell characteristics and pesticide accumulation in egg contents and body fat of caged White Leghorns.


Anticoccidial activity of monensin in floor-pen experiments.


The effect of host beak condition on the size of Menacanthus stramineus populations of domestic chickens.


The effect of dietary fat on aflatoxicosis in turkeys.


Growth and plasma amino acid pattern of chicks fed fish meal as sole source protein: effect of dietary levels of chloride, sulfate, glutamic acid and methionine.


Effect of phenylmercuric acetate injections on phosphatase activity in chickens resistant and susceptible to leukosis.


Effect of mineral mixture composition on chick growth and intestinal pH's.


The effects of anti-sperm antisera and uterine fluids on the fertilizing ability of turkey spermatozoa.


Effects of DDT and its metabolites on thyroid of the Japanese Quail, Coturnix coturnix japonica.


Tolerance of chicks for dimethyl sulfoxide.


Composition of turkey uterine fluid.

Composition of turkey uterine fluid.


Growing performance of egg type chicks vaccinated with a Marek's disease vaccine.


The genetic basis of the birchen pattern of the domestic fowl.


Fecundity and progeny growth following subacute insectide ingestion by the Mallard.


Blood glucose levels in young chickens: the influence of light regimes.


The effects of antibiotics on the reproductive performance of female turkeys.


Growth of Bantam breeds of poultry. I. Embryonic.


Hematological changes in laying hens receiving Sterculia foetida oil supplements.


Quantitative and qualitative protein changes in the developing single comb White Leghorn chicken embryo.


85 Sr: 45 Ca ratios from intestine to egg shell during perfusion with Ca and Sr.


Sexually dichromatic shank melanization associated with the birchen (E R ) allele.


Distribution of gross cutaneous Marek's disease lesions.


Selenium withdrawal and egg selenium content.


Measurement of cerebrospinal fluid pressure in the chicken.


Effect of immobilization and formaldehyde on immunological responsiveness in young chickens.


Crooked neck: an inherited condition in Japanese quail.


Turkey semen evaluation for fertility prediction.


Maximal acid output and the duration of symptoms before surgery in chronic duodenal ulceration.


Latent iron deficiency anaemia in pregnancy.


Long term evaluation of the social and family adjustment to head injuries.


A long-term follow-up study of children with severe head injury.


Right-sided haematomyelia in presubclavian coarctation of aorta.


The Saethre-Chotzen syndrome.

The Saethre-Chotzen syndrome.


An unusual case of sirenomelia.

An unusual case of sirenomelia.


Distribution and fate of nicotine in the rat fetus.


Corticosterone-induced isolated cleft palate in A-J mice.


Transplacental uptake of  127m Tellurium studies by whole-body autoradiography.


Cleft palate formation: a role for pyridoxine in the closure of the secondary palate in mice.


Macrophages in syngeneic animal tumours.


Serum creatinine and creatinine clearance after transfusion with ACD-adenine blood and ACD blood.


Histopathological studies on kidneys from patients treated with large amounts of blood preserved with ACD-adenine.


Platelet enzyme activity during storage. Lactic dehydrogenase, aldolase and electron microscopy correlation.


The occurrence and binding of 2,8-dioxyadenine in plasma.


Studies of the metabolic integrity of human red blood cells after cryopreservation. II. Effects of low-glycerol-rapid-freeze preservation on glycolysis.


New research objectives in craniofacial morphogenesis.


Circumstances limiting the development and verification of a complete explanation of craniofacial growth.


Summary and overlook.

Summary and overlook.


Mechanisms and regulation of mandibular condylar growth.


The role of genetic and local environmental factors in the control of postnatal craniofacial morphogenesis.


The morphogenesis of the human head.

The morphogenesis of the human head.


The role of genetic and local environmental factors in normal and abnormal morphogenesis.


The control or trigger mechanism induced by mechanical forces which causes responses of mesenchymal cells in general and bone apposition and resorption in particular.


A biophysical approach to craniofacial morphogenesis.


Methodology in craniofacial biology.

Methodology in craniofacial biology.


Standardization of risk ratios.

Standardization of risk ratios.


Mortality from stroke among U. S. veterans in Georgia and five western states. V. Seventh and eighth revisions of the International Classification of Diseases as they relate to stroke.


Incidence of cancer in negroes in Washington, D.C. and selected African cities.


Vibrio parahaemolyticus gastroenteritis in Maryland. I. Clinical and epidemiologic aspects.


Radiologic diagnosis of extrahepatic biliary obstruction in jaundiced patients.


Aneurysm of the gastroduodenal artery as a cause of obstructive jaundice. A case report.


The liver in psoriasis.

The liver in psoriasis.


Ulcerative colitis and ulcerative gastritis.


Granulomatous colitis in the elderly.

Granulomatous colitis in the elderly.


Radiological and endoscopic correlation of duodenal ulcers.


The esophagogastric (Schatzki) ring and reflux esophagitis.


Course and treatment of benign esophageal strictures.


The radiology corner. Psoas abscess in granulomatous ileocolitis.


Unusual neoplasms involving the colon.

Unusual neoplasms involving the colon.


The use of hemostatic clips in general surgery.


Isolation of the L-form of Vibrio cholerae from clinical specimens in the Philippines.


Demonstration of endo-N-acetylglucosaminidase and endo-N-acetylmuramidase as impurities in a crude commercial preparation of  -amylase from barley.


Development of extremely attenuated live measles virus vaccine (CAM-EX).


Relationship between virus multiplication and culture cells synchronized by excess thymidine treatment. IV. Autoradiographic studies of cellular and viral DNA syntheses in FL cells infected with cowpox virus using  3 H-deoxycytidine.


The regulation of glyceride synthesis in isolated white-fat cells. The effects of acetate, pyruvate, lactate, palmitate, electron-acceptors, uncoupling agents and oligomycin. 1. The incorporation of 5mm-[U-(14)C]glucose into glyceride fatty acids by fat cells from normal rats incubated in the presence of 20munits of insulin/ml was increased by acetate, pyruvate, palmitate, NNN'N'-tetramethyl-p-phenylenediamine, phenazine methosulphate, dinitrophenol, tetrachlorotrifluoromethyl benzimidazole and oligomycin. Lactate did not stimulate glucose incorporation into fatty acids. The effects of these agents were concentration-dependent. 2. In the presence of 5mm-glucose+insulin, [U-(14)C]acetate, [U-(14)C]pyruvate and [U-(14)C]lactate were incorporated into fatty acids in a concentration-dependent manner, thereby further increasing the total rate of fatty acid synthesis. 3. NNN'N'-tetramethyl-p-phenylenediamine decreased the incorporation of [U-(14)C]pyruvate into fatty acids in normal cells and increased the incorporation of [U-(14)C]lactate into fatty acids. 4. In fact cells from 72h-starved rats the stimulatory effects of NNN'N'-tetramethyl-p-phenylenediamine upon glucose and lactate incorporation into fatty acids were totally and partially abolished respectively whereas the stimulatory effects of acetate upon glucose incorporation were retained. 5. Combinations of the optimum concentrations of the substances that stimulate glucose incorporation into fatty acids were tested and compared. The effects of acetate+NNN'N'-tetramethyl-p-phenylenediamine and acetate+palmitate upon normal cells were additive. The effects of NNN'N'-tetramethyl-p-phenylenediamine+palmitate were not additive. It was found that total fatty acid synthesis in the presence of glucose was most effectively increased by raising the concentration of pyruvate in the incubation system. 6. The significance of these results in supporting the proposal that fatty acid synthesis from glucose in adipose tissue is a ;self-limiting process' is discussed.


Guanine deaminase in rat liver and mouse liver and brain. 1. The guanine deaminase in rat liver supernatant preparations was resolved into two fractions, A and B, on DEAE-cellulose columns. The two differed in electrophoretic mobility and in various properties. The most noteworthy distinction between A and B components was that the enzyme A activity showed a sigmoid dependence on substrate concentration whereas the enzyme B showed classical Michaelis-Menten kinetics. The K(m) value of enzyme A for guanine was 5.3mum and that of enzyme B 20mum. 2. The entire guanine deaminase activity of mouse liver was contained in the 15000g supernatant of iso-osmotic homogenates. 3. A reinvestigation of the behaviour of rat brain 15000g supernatant guanine deaminase isoenzymes revealed that one enzyme had sigmoidal kinetics and the other enzyme showed a hyperbolic response. 4. Of the guanine deaminase in mouse brain iso-osmotic sucrose homogenate 80% was recovered in the 15000g supernatant and the rest from the particles. The supernatant guanine deaminase was resolvable into two fractions on DEAE-cellulose columns. One enzyme showed sigmoidal kinetics whereas the other showed a hyperbolic response to increasing substrate concentration; the K(m) values for the reaction with guanine were respectively 5 and 66mum. 5. The particulate fractions of mouse liver and brain were devoid of any overt inhibitory activity.


Spermine synthesis in the uterus of the ovariectomized rat in response to oestradiol-17 . We reported that spermidine and spermine pools in the uterus both doubled within 24h after oestradiol administration to castrated rats (Russell & Taylor, 1971). Now we have studied the enzymic synthesis of spermine (by spermidine-dependent S-adenosyl-l-methionine decarboxylase) and find that the activity of the enzyme(s) involved is elevated soon after hormone administration. Enzyme activity is increased within 4h and is five times that of controls within 24h. Cycloheximide or actinomycin D administered at the time of oestradiol injection completely blocked the increase in enzyme activity. The enzyme involved in spermine synthesis, S-adenosyl-l-methionine decarboxylase, with S-adenosyl-l-methionine and spermidine as required substrates, was partially purified on Sephadex and DEAE-cellulose columns. The decarboxylation of S-adenosyl-l-methionine could not be separated from the transfer of a propylamine moiety from the decarboxylated S-adenosyl-l-methionine to spermidine to form spermine. We were unable also to separate this system from the enzyme that formed spermidine when S-adenosyl-l-methionine and putrescine are used as substrates. Spermidine-stimulated S-adenosyl-l-methionine decarboxylase has an apparent half-life of 60min, identical with the half-life reported for putrescine-stimulated S-adenosyl-l-methionine decarboxylase. These results strongly suggest that the same enzyme(s) operate in the synthesis of both spermidine and spermine.


The role of glucose in the survival and 'recovery' of the anoxic isolated perfused rat heart. Studies with the isolated perfused working rat heart were carried out to investigate factors that may enable the heart to recover after periods of anoxia. It was found that the presence of glucose in the perfusion fluid during anoxia was essential for complete post-anoxic recovery and the presence of a high concentration of K(+) increased not only the rate of recovery but also the final extent of recovery. In an attempt to clarify the roles played by glucose and K(+) in aiding the survival and recovery of the anoxic myocardium the concentrations of parameters associated with energy liberation and anaerobic glycolysis (ATP, ADP, AMP, P(i), creatine phosphate, glycogen and lactate) were measured in the presence and absence of glucose during the anoxic phase. Determinations of these parameters were carried out during the working aerobic control period, the anoxic period (K(+) arrest) and the recovery period. The results demonstrated that glucose acted as an energy source during anoxia and thus maintained myocardial concentrations of high-energy phosphates, particularly ATP. These studies have also shown a direct relationship between the ability of the heart to recover and the concentration of myocardial ATP at the time of reoxygenation.


Uptake and release of glutamate in cerebral-cortex slices from the rat. 1. Cerebral-cortex slices from rat brain, loaded with labelled l-glutamate as a result of aerobic incubation with labelled glucose, lost less than 15% of this glutamate on subsequent incubation in the presence of unlabelled glucose and l-glutamate. This indicates that very little exchange occurs between extracellular l-glutamate and glutamate accumulated in the neurons as a result of glucose metabolism. 2. Slices, loaded with labelled l-glutamate as a result of aerobic incubation in a medium containing unlabelled glucose and labelled l-glutamate, lost more than half of this glutamate on subsequent incubation in the presence of unlabelled l-glutamate. This indicates that exchange occurs between extracellular glutamate and glutamate accumulated in brain slices as a result of its uptake from the incubation medium. 3. Evidence was obtained suggesting that only a part of the glutamate, accumulated in brain slices as a result of its uptake from an incubation medium containing both glucose and l-glutamate, entered the neurons; apparently almost all the rest entered the glia. 4. It is concluded that the slices contain a pool of glutamate, derived from glucose and located in the neurons, which is poorly exchangeable with extracellular glutamate, and another pool of glutamate, derived from extracellular glutamate and located in the glia, which is freely exchangeable with extracellular glutamate.


Stereochemical aspects of the formation of double bonds in abscisic acid. The stereochemistry of the hydrogen elimination that occurs during the formation of the Delta(4)- and Delta(2)'-double bonds of abscisic acid has been determined from the (14)C/(3)H ratios in abscisic acid biosynthesized by avocado fruit from [2-(14)C,(2R)-2-(3)H(1)]-, [2-(14)C,(2S)-2-(3)H(1)]- and [2-(14)C,(5S)-5-(3)H(1)]-mevalonate. Setting the (14)C/(3)H ratio at 3:3 for [2-(14)C,(2R)-2-(3)H(1)]mevalonate, the corresponding ratio in derived methyl abscisate was 3:2.28; the analogous ratio for methyl abscisate from [2-(14)C,(2S)-2-(3)H(1)]mevalonate was 3:1.63. Removal of the 3'-hydrogen atom of abscisic acid by base-catalysed exchange altered the ratios to 3:1.55 and 3:1.44 respectively. It was concluded that this 3'-hydrogen atom is derived from the pro-2R-hydrogen atom of mevalonate. Removal of the 4-hydrogen atom from methyl abscisate by formation of a derivative, a lactone, lacking this hydrogen atom changed the ratio to 3:1.04 for material derived from [2-(14)C,(2R)-2-(3)H(1)]-mevalonate and to 3:1.05 for [2-(14)C,(2S)-2-(3)H(1)]mevalonate, showing that this hydrogen atom also is derived from the pro-2R-hydrogen atom of mevalonate. These ratios of the lactones are consistent with their retaining one (3)H atom at the 6'-methyl position of abscisic acid from the [(2R)-2-(3)H(1)]- and [(2S)-2-(3)H(1)]-mevalonate. The presence of some label at positions 3' and 4 when [(2S)-2-(3)H(1)]mevalonate was the precursor is attributed to the action of isopentenyl pyrophosphate isomerase. The hydrogen atom at C-5 of abscisic acid is derived from the pro-5S-hydrogen atom of mevalonate.


The role of oxygen limitation in the formation of poly- -hydroxybutyrate during batch and continuous culture of Azotobacter beijerinckii. Azotobacter beijerinckii was grown in ammonia-free glucose-mineral salts media in batch culture and in chemostat cultures limited by the supply of glucose, oxygen or molecular nitrogen. In batch culture poly-beta-hydroxybutyrate was formed towards the end of exponential growth and accumulated to about 74% of the cell dry weight. In chemostat cultures little poly-beta-hydroxybutyrate accumulated in organisms that were nitrogen-limited, but when oxygen limited a much increased yield of cells per mol of glucose was observed, and the organisms contained up to 50% of their dry weight of poly-beta-hydroxybutyrate. In carbon-limited cultures (D, the dilution rate,=0.035-0.240h(-1)), the growth yield ranged from 13.1 to 19.8g/mol of glucose and the poly-beta-hydroxybutyrate content did not exceed 3.0% of the dry weight. In oxygen-limited cultures (D=0.049-0.252h(-1)) the growth yield ranged from 48.4 to 70.1g/mol of glucose and the poly-beta-hydroxybutyrate content was between 19.6 and 44.6% of dry weight. In nitrogen-limited cultures (D=0.053-0.255h(-1)) the growth yield ranged from 7.45 to 19.9g/mol of glucose and the poly-beta-hydroxybutyrate content was less than 1.5% of dry weight. The sudden imposition of oxygen limitation on a nitrogen-limited chemostat culture produced a rapid increase in poly-beta-hydroxybutyrate content and cell yield. Determinations on chemostat cultures revealed that during oxygen-limited steady states (D=0.1h(-1)) the oxygen uptake decreased to 100mul h(-1) per mg dry wt. compared with 675 for a glucose-limited culture (D=0.1h(-1)). Nitrogen-limited cultures had CO(2) production values in situ ranging from 660 to 1055mul h(-1) per mg dry wt. at growth rates of 0.053-0.234h(-1) and carbon-limited cultures exhibited a variation of CO(2) production between 185 and 1328mul h(-1) per mg dry wt. at growth rates between 0.035 and 0.240h(-1). These findings are discussed in relation to poly-beta-hydroxybutyrate formation, growth efficiency and growth yield during growth on glucose. We suggest that poly-beta-hydroxybutyrate is produced in response to oxygen limitation and represents not only a store of carbon and energy but also an electron sink into which excess of reducing power can be channelled.


The conformation of the mucopolysaccharides. Hyaluronates. X-ray-diffraction patterns of hyaluronate fibres from a variety of sources were obtained. Sodium hyaluronate gives well-defined patterns which index on a hexagonal unit cell with dimensions a=1.17+/-nm and a fibre repeat-distance of 2.85+/-0.03nm. A further form of sodium hyaluronate is produced by annealing at 60 degrees C in 75% relative humidity. This stable state indexes on a hexagonal unit cell of unchanged fibre repeat-distance but with a=1.87nm. The chain conformation is a threefold helix. Analysis of these diffraction patterns led to two tentative structures for sodium hyaluronate, involving different packing of the polysaccharide chains. The significance of side-chain interaction is discussed. Hyaluronic acid produces an X-ray pattern different from that obtained with the sodium salt. The fibre repeat-distance is 1.96+/-0.02nm and the unit cell appears to be monoclinic. The chain conformation is a twofold helix and conformational change between free acid and monovalent salt is discussed. These findings, together with model-building experiments, are interpreted as indicating a highly ordered structure, and the physical properties of hyaluronate solutions with regard to molecular shape and polyelectrolyte behaviour are rationalized.


Photosynthesis by isolated chloroplasts. Inhibition by DL-glyceraldehyde of carbon dioxide assimilation. Photosynthetic carbon assimilation and associated CO(2)-dependent O(2) evolution by chloroplasts isolated from pea shoots and spinach leaves is almost completely inhibited by 10mm-dl-glyceraldehyde. The inhibitor is without appreciable effect on photosynthetic electron transport, photophosphorylation, the carboxylation of ribulose 1,5-diphosphate or the reduction of 3-phosphoglycerate, but apparently blocks the conversion of triose phosphate into ribulose 1,5-diphosphate.


Developmental changes in tissue and plasma concentrations of the biologically active species of nerve growth factor in the mouse, by using a two-site radioimmunoassay. A sensitive and specific radioimmunoassay has been developed for the biologically active beta-subunit of the mouse submaxillary-gland nerve-growth-factor protein. This assay is based on the ;two-site' radioimmunoassay method of Addison & Hales (1971), and a detailed description of the experimental method is given. The assay is readily adaptable for the rapid assay of nerve growth factor in partially purified preparations, or can be used as a sensitive method for measuring the low tissue concentrations of this protein, measurement of concentrations as low as 0.25ng/ml in plasma or tissue extracts being possible. This assay was used to determine tissue concentrations of nerve growth factor in adult mice and developmental changes in its content in various tissues. There were significant sex differences in the nerve-growth-factor content of submaxillary glands, plasma and sympathetic ganglia, with males having higher concentrations, whereas the concentrations in all other tissues measured showed no significant difference between male and female animals. The changes in plasma concentration of the factor during development parallel the changes observed in the submaxillary gland, and it was suggested that plasma nerve growth factor may be derived mainly from this source. Circulating nerve growth factor appears to be specifically concentrated in sympathetic ganglia. There is a relatively high concentration of the factor in neonatal ganglia and plasma, and it is suggested that this may be derived from maternal sources.


Fatty acid biosynthesis in rabbit mammary gland during pregnancy and early lactation. The pattern of fatty acids synthesized by mammary-gland explants from rabbits during pregnancy and early lactation has been studied. From day 12 to day 18 of pregnancy, long-chain (C(14:0)-C(18:1)) fatty acids were the major products. From day 18 to day 21 of pregnancy there was an increase of up to 12-fold in the rate of fatty acid synthesis per unit wet weight of tissue that was almost exclusively caused by the synthesis of octanoic fatty acid and decanoic fatty acid, which are characteristic of rabbit milk. These medium-chain fatty acids were mainly incorporated into triglycerides. From day 22 to day 27 of pregnancy there was little change in the rate of fatty acid synthesis and the proportions of fatty acids synthesized were essentially the same as those synthesized by the lactating gland, i.e. 80-90% octanoic acid plus decanoic acid. About 2-4 days before parturition a second lipogenic stimulus occurred, although the pattern of fatty acids synthesized did not change.


Purification and properties of adenosine triphosphate-creatine phosphotransferase from muscle of the dogfish Scylliorhinus canicula. 1. Creatine kinase occurs in high concentration in the soluble proteins of dogfish muscle. A fourfold purification gives essentially pure enzyme but with a low specific activity. This appears to be a property of the native enzyme and not a result of the isolation procedures used. 2. The amino acid composition is similar to that of other phosphagen kinases, but the enzyme differs from mammalian creatine kinases in having four thiol groups readily reactive towards 5,5'-dithiobis-(2-nitrobenzoic acid). Titration of two thiol groups is accompanied by almost complete loss of activity. The remaining two thiol groups react at different rates, suggesting that modifying the third thiol group affects the reactivity of the fourth thiol group. 3. The enzyme is markedly protected against inactivation by iodoacetamide by MgATP or MgADP. Addition of creatine to MgADP decreases protection, but the further addition of Cl(-) restores protection to the original value. The quaternary MgADP-creatine-enzyme-nitrate complex protects very strongly as is found for the rabbit enzyme. The involvement of the conformational state of the enzyme in such effects is discussed. 4. Creatine kinase from both dogfish and rabbit is equally sensitive to urea denaturation. Urea protects the dogfish enzyme by about 9% against inhibition by iodoacetamide. 5. The formation of a hybrid between the dogfish and rabbit enzymes in vitro has been demonstrated. 6. At high substrate concentrations the dogfish enzyme shows apparent ordered kinetics. The effect of temperature on V(max.) and the Michaelis constants for MgATP and creatine were determined. These and changes in the apparent activation energy suggest that limited adaptation has occurred commensurate with physiological need.


The frequency of errors in protein biosynthesis.


Dolichols, ubiquinones, geranylgeraniol and farnesol as the major metabolites of mevalonate in Phytophthora cactorum. Farnesol, geranylgeraniol, dolichols and ubiquinones were the main radioactive components of the unsaponifiable lipid recovered from Phytophthora cactorum grown in aerated cultures containing [2-(14)C]mevalonate. The (14)C recovered in each of these components was in the approximate proportion 2:4:3:5. When the culture was not aerated no radioactive ubiquinone was recovered. Most of the (14)C recovered in the dolichols was found in dolichol-15 (37%), with decreasing amounts in dolichol-14 (30%) and -13 (14%) and only a little (5%) in dolichol-16, whereas the major components, by weight, of the mixture (13mug/g of damp-dry tissue) were dolichol-14, -15 and -16 in the approximate proportion of 1:3:1. Radioautography of appropriate chromatograms indicated the presence also of traces of radioactivity in dolichol-9, -10, -11, -12 and -17. Most (80%) of the (14)C recovered in the ubiquinones was associated with ubiquinone-9, the rest being in ubiquinone-8. Most (80%) of the weight of ubiquinones (19mug/g of damp-dry tissue) was also ubiquinone-9. The identification of these compounds was by chromatographic methods and, for the ubiquinones and dolichols, was confirmed by mass spectrometry. In addition, the incorporation of 4R- and/or 4S-(3)H from [4-(3)H]-mevalonates showed the expected stereochemistry of biosynthesis, namely that farnesol, geranylgeraniol and ubiquinones were biogenetically all trans and the dolichols each contained three biogenetically trans isoprene residues, the remaining residues being biogenetically cis. The distribution of (14)C in the components of the whole lipid of the fungus was consistent with 97% of both the farnesol and geranylgeraniol being present as the fatty acid ester. The corresponding value for dolichols was 37%. The observation by other workers, that this fungus does not form either squalene or sterol, was confirmed.


Isolation and identification of 2-hydroxyoestrone 3-methyl ether from the urine of pregnant women.


Inhibition by derivatives of rifamycin of soluble ribonucleic acid polymerase from rat liver.


Hexose phosphate synthese and tricarboxylic acid-cycle enzymes in bacterium 4B6, an obligate methylotroph.


Children's road behaviour and personality.


The relationships between intelligence, personality and creativity under two conditions of stress.


Exploratory studies of early cognitive development.


A developmental study of attention.

A developmental study of attention.


Towards the interpretation of children's lie scale scores.


Personal correlates of bureaucratic orientation.


The effect of providing a warning about the lie scale in a personality inventory.


The persistence and fate of fernitrothion insecticide in a forest environment.


DDT in forest trees and lumber.

DDT in forest trees and lumber.


Pesticide levels in deer.

Pesticide levels in deer.


Metabolism of diazinon by fish liver microsomes.


The interaction of plantinum II compounds with bacteriophages T7 and R17.


N-methyl-N-nitrosourea induced changes in the labeling by ( 14 C)orotate of RNA and acid-soluble fractions in rat kidney and liver.


Studies concerning the possible involvement of singlet oxygen in the microsomal oxidation of aromatic substrates.


Children's perceptions of internal-external control in intellectual-academic situations and their Embedded Figures Test performance.


The antecedents of social desirability response tendencies of children and young adults.


Infant crying and maternal responsiveness.


Effects of mother-infant separation on maternal attachment behavior.


Evidence for class-concept mediation of perceptual sets in preschool children.


Individual differences in neonatal preferences for planometric and stereometric visual patterns.


Development of audiovisual integration in normal and retarded readers.


The development of laughter in the first year of life.


Stimulus orientation and the apparent developmental lag between perception and performance.


The development of the distinction between perceiving and memorizing.


Visual scanning strategies of reflective, impulsive, fast-accurate, and slow-inaccurate children on the Matching Familiar Figures Test.


Correlational analysis of motor and verbal activity in young children.


The visual information processing speed of lower- and middle-class children.


Effects of aggressive and nonaggressive male and female models on the behavior of emotionally disturbed boys.


The relation of internal-external control to academic performance.


Synchronous reinforcement of vocal responses in failure-to-thrive infants.


Basophil leucocyte separation from human peripheral blood: a technique for their isolation in high purity and high yield.


Asthma due to inhaled wood dusts, Western red cedar and Iroko.


Respiratory symptoms following brief exposure to Cedar of Lebanon (Cedra libani) dust.


Asthma due to inhaled chemical agents, tolylene di-isocyanate.


An hypothesis for the development of atopic allergy in man.


Hyposensitization with extracts of Dermatophagoides pteronyssinus and house dust.


Correlation of skin, nasal and inhalation tests with the IgE in the serum, nasal fluid and sputum.


The cocoonase zymogen cells of silk moths: a model of terminal cell differentiation for specific protein synthesis.


Classical conditioning in the leech Macrobdella ditetra as a function of CS and UCS intensity.


Transference, discrimination and reversal. A comparison between normals and pathological groups.


Variations in the training parameters of an avoidance conditioning paradigm and their effects on the acquisition and performance.


Derivatives of pyrrolo(2,1-a)isoquinoline. II. Monoamides of 5,6-dihydropyrrolo(2,1-a)isoquinoline-2,3-dicarboxylic acids.


Classical conditioning and extinction of human systolic blood pressure.


Sleep and overextinction of the GSR component of the orienting response.


Schizophrenia and the Balinese.

Schizophrenia and the Balinese.


Prostaglandins. IV. 5-Cis-13-trans-14-chloroprostadienoic and 5-cis-prosten-13-ynoic acids.


Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Among mice of strain SB/Le, homozygous for the mutant genes beige (bg), satin (sa), and white-bellied agouti (A(w)), 70% developed progressive pneumonitis by 6 months of age. Among backcross offspring from an outcross to C57BL/6J-A(w-J), 49% of homozygous beige and 11% of nonbeige genotypes developed pneumonitis by 6 months of age. The evidence indicates that a specific action of the beige gene increases susceptibility to progressive pneumonitis. Lymphadenopathy, including reticulum cell neoplasms and atypical lymphoproliferative lesions, was observed in high incidence in sa+/sa bg males, suggesting a closer association with satin than with beige. Beige mice show giant lysosomal granules in the leukocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle. Strain SB/Le provides a convenient model in a laboratory animal for study of the increased susceptibility to infection analogous to that of the Chediak-Higashi syndrome.


Studies on the sal locus in Drosophila pseudoobscura. II. Modes of regulation of the sal banding pattern. From a consideration of genetic and chromosomal alterations which affect the banding pattern of a specific salivary chromosome region, it is concluded that (1) a regulator locus, sal, is closely linked with the region in question but separated from it spatially by a few bands; (2) either mutation of the sal locus or transfer of the region to a heterochromatic region affects the banding pattern similarly; and (3) the change probably consists of a compaction of DNA and a concomitant inactivation of genetic loci.


Circular DNA molecules in the genus Drosophila. The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster. Analyses of cell fractions from adult Drosophila and organ fractions from Drosophila larvae show that fractions containing mitochondria are highly enriched in these molecules.


Chemical selection of alcohol dehydrogenase negative mutants in drosophila. We describe a selection procedure which utilizes the vapor from an unsaturated alcohol, 1-pentene-3-ol, for the detection and isolation of mutant flies with little or no alcohol dehydrogenase activity. ADH-negative flies are unaffected by exposure to the unsaturated alcohol, but ADH positives (wild-types) die after short exposure. The technique can be used to select rare ADH-negative individuals from large populations of wild-type flies.


Preferred skin temperature as a function of internal and mean skin temperature.


Improved exercise tolerance during venous congestion.


Airway closure in children.

Airway closure in children.


Effect of maturation and training on mitochondrial size distributions in rat hearts.


Role of vagus nerves in experimental asthma in allergic dogs.


Ethnic differences in physical working capacity.


Ventilatory response to work initiated at various times during the respiratory cycle.


Effect of hypoxia on free fatty acid metabolism during exercise.


Quantitation of regional aerosol clearance in the normal human lung.


Fluid composition from implanted perforated capsules: an approach to interstitial fluid?


Critical water temperature and effective insulation in scuba divers in Hawaii.


Distribution of blood flow in the lungs in acute pulmonary edema in dogs.


Acute changes in lung mechanics following pulmonary emboli of various gases in dogs.


Effect of speed vs. grade and shivering on ventilation in dogs during active exercise.


Succinylcholine, ocular pressure, and extraocular muscle tension in cats and rabbits.


Autonomic nervous control of cardiac frequency in the exercise-trained rat.


Longitudinal variations in maximal oxygen intake with age and activity.


Muscle metabolism during exercise with concentric and eccentric contractions.


Core rewarming by peritoneal dialysis following induced hypothermia in the dog.


Lung compliance, lung volumes, and single-breath diffusing capacity in dogs.


Augmentation of chemosensitivity during mild exercise in normal man.


Inhibition and reversal of intranuclear RNA synthesis by hyperatmospheric oxygen.


A simple measurement of phase IV ("closing volume") using a critical orifice helium analyzer.


An environmental chamber for studying chronic hypercapnia in dogs.


Simultaneous single-breath measurements of foreign gases in lung and expired air.


Determination of pulmonary extravascular water using oxygen 15-labeled water.


Problems of communicable diseases and their control in developing countries.


Single-breath method of measuring cardiac output--a reevaluation.


Helobdella punctato-lineata as a potential predator of Biomphalaria alexandrina snail populations under laboratory conditions.


A preliminary note on toxoplasmosis among inpatients of the obstetrics department, university hospital at Assiut, Egypt.


Seroconversion after live rubella virus vaccine.


Two cases of XYY syndrome in Argentina.

Two cases of XYY syndrome in Argentina.


Familial hyperargininemia.

Familial hyperargininemia.


Biomechanical properties of delipidized stratum corneum.


Effects of long ultraviolet rays on human skin: photoprotective or photoaugmentative?


Culture of dermatophytes upon stratum corneum.


Fine structure of perifollicular nerve endings in human hair.


Studies on the mechanism of the anti-melanoma effect of polyinosinic-polycytidylic acid (PIC). II. Decreased growth of B-16 melanoma from prior exposure to the tumor. Abrogation of this response by PIC.


The trend of mortality from primary malignant tumors of skin.


Preservation of tissue-fixed immunoglobulins in skin biopsies of patients with lupus erythematosus and bullous diseases--preliminary report.


Radiosensitivity of mammalian cells. VII. Aggregation and pseudo-glomerule formation of dissociated kidney cells from irradiated new born mice.


Analytical methods for ruthenium-106 in marine samples.


The loss of radionuclides in marine organisms during thermal decomposition.


Incorporation of radioactive cobalt into the eggs of domestic fowls.


Modification of radiation lethality in mice by antithrombocyte serum injection.


Radiation protection by 2-mercaptopropionylglycine in mice.


Correlations of physical fitness, perceived health status, and dispensary visits with performance in stressful training.


Resting metabolic rate and energy cost of some common daily activities of trained and untrained tropical people: energy metabolism in training in Tropics.


Relationships of sports interests and smoking to physical fitness.


A study on the excreted catecholamines in the urine of Bobsleigh-tobogganing contestants.


The effects of exercise on the coronary collateral circulation.


The effects of three liquids on exhaustive exercise and absorption following a 2 percent body weight loss as a result of acute dehydration.


Effect of amateur wrestling on selected serum enzymes.


Exercise physiology at the cellular level.


Tumor associated antigen in the chemotherapy of solid tumors.


Immunologic response to melanoma of sensitized perfused bone and spleen.


Multiple arterial infusions with 5-fluorouracil.


Toludine blue test for detection of carcinoma of the oral cavity: an evaluation.


5-Methyl-cytidine as an inhibitor of spontaneous cancer in mice.


Laparotomy and splenectomy in Hodgkin's disease--diagnostic, preventive and therapeutic.


Radiotherapy in advanced prostatic carcinoma.


The plasma gelation by ethanol in the diagnosis of disseminated intra-vascular coagulation.


Fundamental and clinicopathological studies on human gonadotropin actions on anovulatory diseases. I. Studies on the effects of human gonadotropin on ovarian steroidogenesis and ovulation.


Experimental studies on the detection of hypnotics using thin layer chromatography.


Fundamental and clinicopathological studies on human gonadotropin actions on anovulatory diseases. II. Studies on the clinical results of artificial induction of ovulation with human gonadotropins and a new trial classification of anovulatory ovaries.


Simultaneous electrolyte, urea and bicarbonate determination.


Applications of the pro-milk MK II. IV. Monitoring the degree of denaturation of whey proteins in heat processing of milk, and the heat treatment classification of milk powders.


Modified Monier-Williams apparatus for sulphur dioxide determination.


Ultrafiltration for concentration and desalting of proteins in solution.


Cigarette smoking machine for animal experiments.


Early mobilization and discharge after myocardial infarction.


Preliminary planning pays off.

Preliminary planning pays off.


Podiatry service in a suburban hospital.


Malignant melanoma.

Malignant melanoma.


Pre-employment physical examinations.

Pre-employment physical examinations.


Some medico-legal aspects of heart disease. I.


Urinary tract obstruction in causation of infection, stone formation and renal failure.


Preschoolers' speech disfluency: single syllable word repetition.


Deaf and hearing children's performance on a tactual perception battery.


Perceptual narrowing as a function of peripheral cue relevance.


Pattern meaningfulness and discrimination latency for repeated task administrations.


Effects of noise and response complexity upon vigilance performance.


Apparatus note: a system for detecting and recording movements of the head.


Critical periods for early experience in transfer of perceptual learning.


Cognitive styles in children and performance on Piagetian conservation tasks.


The Ponzo illusion from induced double image of a single test line.


Estimation of the passing of four consecutive hours.


Monitoring and reinforcement by parents as a means of automating articulatory responses.


Cognitive style and style of adaptation.


Weather, mood, and internal-external control.


Effects of left and right cerebral lesions on the naming process.


Effect of methamphetamine on water consumption.


Hypobaric hypoxia: within-subject transition effects in albino rats.


Haptic perception of the Mueller-Lyer illusion by the blind.


Effects of prior commitment on children's evaluation and imitation of a peer model's perceptual judgments.


Acquisition of visual-auditory associations by good and excellent readers.


An attempt to demonstrate contralateral masking in pressure adaptation.


Sex differences in time estimation.

Sex differences in time estimation.


Visual attention and distraction in aphasic and non-aphasic children.


Surface colouration, lettering and referential dimension of traffic marker perception.


Effect of marihuana upon peripheral vision as a function of the information processing demands in central vision.


Effect of marihuana on the visual autokinetic phenomenon.


Perceptual-motor abilities of disadvantaged and advantaged kindergarten children.


Individual differences in eye-movement patterns.


On the internal consistency of magnitude estimations.


Visual counting in different directions.


Discrimination and generalization of complex visual shape variations in pigeons.


Effects of four noise conditions on arithmetic performance.


Odor artifacts of an olfactometer evoke a CER in the rat.


Children's size-difference judgments: latency and amplitude effects associated with degree of stimulus similarity.


Cognitive complexity and affective value of literary stimuli.


Gesell speech norms and Israeli children.


Some factors in the recognition of tachistoscopically presented alphabetical arrays.


Influence of visual enrichment on infants' visual preferences.


Magnitude estimation of absolute distance underwater.


Perceptual responses during prolonged work.


Use of video-tape feedback in swimming instruction with emotionally disturbed children.


Diametrically opposed discriminations mediated by a single cerebral hemisphere: effects of further anterior and posterior cortical ablations.


Rate of norepinephrine synthesis after tyramine-induced depletion of norepinephrine in rat heart.


Auditory-visual integration, school demographic features and reading achievement.


Antagonisms of hexamethonium actions by choline.


Relationship of dietary essential fatty acid consumption to hepatic drug hydroxylation.


Differences in microsomal enzyme induction between Sprague-Dawley and Long-Evans rats.


Urinary total hydroxyproline, calcium and phosphorus excretion after administration of calcium and oestrogen to postmenopausal women.


Action of epinephrine on amino acid uptake into rat diaphragm in vitro and in vivo.


Effect of  -methyl-tyrosine pretreatment on the drug-induced increase of hippocampal RNA.


Behavioural actions of anticholinergic drugs.


Centrally acting cholinolytics and the choice behaviour of the rat.


The effect of atropine on the metabolism of acetylcholine in the cerebral cortex.


The effects of anticholinergic drugs, chlorpromazine and LSD-25 on evoked potentials, EEG and behaviour.


Factors influencing the release of prostaglandins from the cerebral cortex.


Behavioural actions of some substituted amphetamines.


The actions of drugs on single neurones in the brain.


Access of quaternary drugs to the central nervous system.


Action of phospholipase A on synaptic vesicles. A model for transmitter release?


The application of zonal centrifugation to the study of some brain subcellular fractions.


Chemical and stereochemical aspects of behavioural studies.


Changes in the properties of acetylcholinesterase in the invertebrate central nervous system.


Hallucinogenic drugs and circadian rhythms.


Effects of some centrally acting drugs on caeruloplasmin.


Possible determinants of aggression.

Possible determinants of aggression.


Cerebral calcinosis with polycystic encephalopathy. An unusual case.


The role of aggression in human pathology. Discussion introduction.


Some theoretical remarks about the theme aggression.


Some theoretical remarks about the theme aggression. Discussion to the paper of P.C. Kuiper.


Assement of hostility in the course of psychosomatic treatment of three patients with functional disorders. II.


Visual form perception: tachistoscopic experiment.


Assement of hostility in patients with functional cardiac complaints. I.


General comments on the role of aggression in human psychopathology.


Some methodological comments to the assessment of hostility on the level of molar behaviour in the course of psychosomatic treatment of functional disorders.


A therapeutic bias in making psychiatric diagnoses.


The study of human aggression. Some remarks preceding and following the showing of the film 'Because I left my bicycle there' by Louis van Gasteren.


Telemetric measurement of motor activity in maladjusted children under different experimental conditions.


Time-dependent pressure-volume relationships of the in vivo canine trachea.


Hydrogen ion balance in the elasmobranch Scyliorhinus stellaris after exhausting activity.


Cross-current gas exchange in avian lungs: effects of reversed parabronchial air flow in ducks.


The influence of age, sex, body size and lung size on the control and pattern of breathing during CO 2  inhalation in Caucasians.


Neural and mechanical mechanisms of feline purring.


Effects of cardiac output on  18 O 2  lung diffusion in normal resting man.


Pv O 2  by nitrogen rebreathing--a critical theoretical analysis.


Neurophysiological investigations of medullary chemosensitive areas of respiration.


The effect of hyperammonemia on lymph flow and free water excretion.


Lumbar open-end manometry of CSF and physiologic reactance.


The beginning of mental activity in man and its importance to law. A new theory.


The induction of the enzymic "detoxication" system in liver cells.


Pulmonary fate of intravenous norepinephrine.


Location of lymphocytes in endothelium of postcapillary venules of rat lymph node.


Some problems of postgraduate training for physicians and pharmacists in S. R. of Czechoslovakia.


Some new trends in medical education and the teaching of social medicine.


Cardiovascular diseases in the light of epidemiological studies of the population in Poland.


Principles of community-wide prevention and control of cardiovascular diseases.


The uncomplicated post-traumatic cervical syndrome.


Summary for the international symposium on rehabilitation in head injury.


The relationship between four tests of back muscle strength in untrained subjects.


Anthropometric measures and muscle strength in young women.


Driver evaluation and training in a comprehensive rehabilitation center.


A new training device for rehabilitation during workshop training.


Electrophysiology of the ureter. An experimental animal model.


Educational problems in the urological specialty.


Clinical staging of neurogenic bladder dysfunction.


Clinical urodynamics. Methods and results.


Torsion of the testis.

Torsion of the testis.


Forefoot plethysmography in immediate and late postoperative control after reconstructive vascular surgery.


Peripheral and renal venous plasma renin concentration in hypertensive patients with unilateral renal or renovascular disease.


Urology in the Nordic countries.

Urology in the Nordic countries.


Ultrasonically guided percutaneous puncture of renal masses.


Porto-renal end-to-end shunt. Report of a non-traditional case.


Experiences with percutaneous renal biopsy.


Ultrasonic diagnosis of juxtarenal masses.


Angiographic and conventional radiographic examination of renal pelvic carcinoma.


Diagnostic and therapeutic problems in spontaneous Cushing's syndrome. A review with five case reports.


Consierations for the performance of radionuclide procedures in children.


Radionuclide imaging studies of gastrointestinal disorders.


Pediatric radionuclide cisternography.

Pediatric radionuclide cisternography.


Gonorrhea control program is under way.

Gonorrhea control program is under way.


Medicine and the law--court holds 'good will' not a community asset.


Private medicine-health department partnership for health.


Purposes and functions of a department of community medicine.


Health departments: quo vadis?

Health departments: quo vadis?


The tympanic ventilating tube: its role in eustachian tube dysfunction.


Pediatric grand rounds: smoke inhalation and respiratory burns.


Radiological manifestations of marginal ulcer.


Restoration of the reactivity of frozen stored human lymphocytes in the mixed lymphocyte reaction and in response to specific antigens.


The effect of synthetic polynucleotides on immunologically induced tritiated thymidine incorporation. Amplification of response.


Guinea pig lymphotoxin and comparison of various assay methods for cytotoxicity.


A venture in health care reform.

A venture in health care reform.


Testing of wild mice for "private" H-2 antigens. Cross reactions or nonspecific reactions?


A brief review with emphasis on septic shock.


Cerebral disconnection. An avenue for further investigation of emotional behavior.


The chronic "running ear". Corrective surgery and subsequent restoration of hearing.


Antimicrobial susceptibility of common bacterial species.


Clinical and laboratory aspects of hookworm infection and anaemia.


Subdural hygroma after head injury. A review of 26 cases.


Circulation disorders of the spinal cord.


The treatment of peripheral nerve injuries with homologous nerve grafts.


Intradural arachnoid cysts with scalloping of vertebrae in the lumbosacral region. A case report and review of the literature.


Cerebro-spinal fluid rhinorrhea in empty sella. Case report.


Some factors affecting flight in field populations of the Australian plague locust, Chortoicetes terminifera (Walker), in New South Wales.


Extra-optic photoreception and compass orientation in larval and adult salamanders (Ambystoma tigrinum).


Observations on the behaviour of the grasshopper Taeniopoda eques (Burmeister), Orthoptera, Acrididae.


Olfactory pregnancy-block in mice (Mus musculus): an unusual response acquisition paradigm.


Tongue movements in the common boa (Constrictor constrictor).


Sexual displays and mating of Octopus vulgaris Cuvier and O. cyanea Gray and attempts to alter performance by manipulating the glandular condition of the animals.


Habituation, reinstatement and recovery of predatory responses in two species of teleosts, Carassius auratus and Macropodus opercularis.


Board certifying examinations.

Board certifying examinations.


Penicillin after splenectomy?

Penicillin after splenectomy?


Artifacts in portable ECG monitoring.

Artifacts in portable ECG monitoring.


Reserpine and Raynaud's phenomenon.

Reserpine and Raynaud's phenomenon.


Temporal arteritis and polymyalgia rheumatica. Clinical and biopsy findings.


Phycomycosis complicating leukemia and lymphoma.


Sepsis caused by contaminated intravenous fluids. Epidemiologic, clinical, and laboratory investigation of an outbreak in one hospital.


Serum viscosity and hyperviscosity syndrome in IgG multiple myeloma. Report on 10 patients and a review of the literature.


Reducation of digitalis toxicity by computer-assisted glycoside dosage regimens.


Mortality from renal diseases among former college athletes.


Survival with carcinoma of the esophagus.


Central congestive fibrosis of the liver in myxedema ascites.


Clinical rubella with arthritis resulting from reinfection.


Acute exacerbation of ankylosing spondylitis after an iron dextran infusion.


Antibiotic management in patients with chronic bronchitis and emphysema.


The coronary collateral circulation.

The coronary collateral circulation.


Sickle-cell trait: benign or malignant?

Sickle-cell trait: benign or malignant?


Potential hazards of hydantoin use.

Potential hazards of hydantoin use.


Radiolucent foreign bodies.

Radiolucent foreign bodies.


Assessment of iron deficiency in children with congenital heart disease.


Hypertension due to radiation nephritis in a child.


Examination of the carcinogenic and cocarcinogenic effects of Grenz radiation.


Familial chloride diarrhoea (congenital alkalosis with diarrhoea).


A model system for the evaluation of the role of cholesterol  -oxide in ultraviolet carcinogenesis.


Cytokinetic and molecular pharmacology studies of arabinosylcytosine in metastatic melanoma.


Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.


The effects of arabinosylcytosine on cultured human lymphoma cells.


A distinction between 3-methylcholanthrene and estrogen binding in the uterus.


Effect of irradiation on mouse salivary glands during the prereplicative phase of isoproterenol-stimulated DNA synthesis.


Macrophage production by the bone marrow of tumor-bearing mice.


Absence of plasma erythropoietin in mice with anemia induced by Rauscher leukemia virus.


Release of thymidine from x-irradiated spleen in the rabbit as determined by a new bioassay.


Enzymatic mechanisms during temperature acclimation of the blue crab, Callinectes sapidus. I. Oxygen consumption and activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.


Enzymatic mechanisms during temperature acclimation of the blue crab, Callinectes sapidus. II. Kinetic and thermodynamic studies of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.


Enzymes in honey bee (Apis mellifera L.) hemolymph.


Epididymal carbohydrate metabolism. II. Substrates and pathway utilization of caput and cauda epididymal tissue from the rabbit, rat and mouse.


Arginine and urea metabolism in the South American land snail, Strophoceilus oblongus.


Amino acid metabolism in chameleon liver.


Ornithine cycle and uricolytic enzymes in four bivalve molluscs.


Allocholic acid, the major component in bile from the river carpsucker, Carpiodes carpio (Rafinesque) (Catostomidae).


Lens iso-precipitin in yellowfin tuna (Thunnus albacares).


Effect of anti-PMS serum on follicular ovulability in hypophysectomized immature female rats pretreated with PMS.


Sexual differentiation of steroid metabolizing enzymes in the rat liver. Further studies on predetermination by testosterone at birth.


Hormone metabolism and action. II. Androstenedione in prostate organ culture.


Light regulation of rat retinal hydroxyindole-O-methyl transferase (HIOMT) activity.


Lack of positive correlation between adenyl cyclase activity and iodide transport in rat thyroids.


Corticosteroidogenesis in vitro by the head kidney of Tilapia mossambica (Cichlidae, Teleostei).


Ovarian binding of intact and desialytated hcg in vivo and in vitro.


Growth hormone secretion and control in the mouse.


Mechanism of growth hormone (GH) action on erythropoiesis.


Interaction of FSH and hCG on follicle development in the ovarian augmentation reaction.


In vitro testosterone-14C metabolism by rat seminiferous tubules at different stages of development: formation of  -androstandiol at meiosis.


Lipolytic activity of gonadotropins and their subunits.


Studies on the dynamics of plasma androgens and on the origin of dihydrotestosterone in dogs.


Plasma levels of prolactin, growth hormone and insulin in sheep following the infusion of arginine, leucine and phenylalanine.


Response of adrenalectomized rats to chronic exercise.


The hypocalcemic effect of ethyl alcohol in rats and dogs.


Failure to detect excessive stress-induced adrenal corticosterone secretion following amino-glutethimide withdrawal in the rat.


Estrogen receptors in the human uterus: characterization by sucrose gradient centrifugation.


Seasonal variations in the onset of puberty in rats.


Studies on antigenic competition. 3. Is there a competitive step in tolerance induction?


Cellular heterogeneity in the thymus. I. Electrophoretic analysis of lymphoid cell populations from chickens.


Anaphylatoxin formation by contact activation of plasma. 3. Fixation of two different anaphylatoxin-forming complexes on zymosan.


Differences in the constitution of antibody combining site in different mice strains.


Low zone tolerance: a possible defect in the switch from IgM to IgG production.


The fine structure of complement-receptor lymphocytes in mice.


Evidence of RNA in the helices of Amoeba proteus.


Changes in cellular parameters during synchronous meiosis in Ulva mutabilis Foyn.


Interaction between anaesthetics and hydrostatic pressure in the division of Tetrahymena pyriformis W.


Preparation of viable and morphologically intact cells from newborn rat brain.


Nucleoprotein changes and uridine incorporation in rat thymus lymphocytes. I. Cellular characterization of age-dependent thymus involution.


Sea urchin nuclear DNA polymerase. IV. Reversible association of DNA polymerase with nuclei during the cell cycle.


Biochemistry of differentiation of mouse trophoblast: esterase.


Temperature-sensitivity of mouse testicular DNA synthesis in vitro.


Low molecular weight RNA in lymphocytes of chronic lymphocytic leukemia.


Studies on biosynthesis of soluble proteins in early amphibian development by isoelectric focusing in thin layer polyacrylamide gel.


Radiation-induced non-random chromosome breakage.


Some characteristics of the morphogenic inhibitor in blastocoelic fluid from sea urchin embryo.


Survival of Acholeplasma laidlawii A and changes in its DNA after irradiation with X- and gamma rays.


The complex nature of antigen HL-A.2 absorption studies of anti-HL-A.2 sera on cells from white and black individuals.


Jailhouse medicine--travesty of justice?


Changes in DNA sensitivity to acid hydrolysis during cell cycle.


Clinics for migrants.

Clinics for migrants.


Characteristics of clinic personnel may influence family planning acceptance.


The health sciences careers program.

The health sciences careers program.


Vasectomy and psychosexual damage.

Vasectomy and psychosexual damage. The director of the Family Planning Project of the San Bernardino County (California) Health Department reviews the results of a questionnaire completed by 300 husbands and their wives 6 months to 1 year after vasectomy.  The replies indicated psychosexual damage from vasectomy is virtually nonexistent.  100% of the males reported an enhanced or unchanged sense of masculinity.  Vasectomy clinics have been conducted by the San Bernardino County Health Department since August 1970.  More than 1000 vasectomies have been completed.  Vasectomies are currently being performed at a rate of 12/week.  Prevasectomy group counseling should inform couples of 1) the physiological mechanisms involved, 2) the situational nature of any psychologic changes, and 3) the probability of irreversibility of the procedure.


A review of teenage nutrition in the United States.


Reporting of congenital malformations on birth certificates.


Public information training and practices in 50 Oklahoma county health departments.


Influenza epidemic in Pennsylvania.

Influenza epidemic in Pennsylvania.


Motivations as predictors of health behavior.


Use of multiple mycobacterial antigens in skin testing among the Navajo.


The infantile proximal spinal muscular atrophies in Switzerland.


Entero-insular axis and relationship between insulin and growth hormone in the normal and obese child. Effects of oral lipidic and proteic load.


Perinatal mortality and morbidity in "small-for-dates" newborns.


Exchange transfusion and hyperbaric oxygen in the treatment of children with acute hepatic failure.


Assessment of the pituitary adrenal cortex axis in children by a single dose metyrapone test.


Multiple exchange transfusions as treatment during the acute period in maple syrup urine disease.


Effect of dietary supplementation with high protein biscuits on the nutritional status of pre-school children.


Keratomalacia and intestinal helminthiasis.


Lead encephalopathy: report of a case.

Lead encephalopathy: report of a case.


Neonatal seizures.

Neonatal seizures.


Congenital leukaemia.

Congenital leukaemia.


Comparative trial of Liv 52 and Orabolin in marasmus.


Megaloblastic anaemia of infancy: a clinical and haematological study of 210 patients.


Leg lengthening in poliomyelitis.

Leg lengthening in poliomyelitis.


Stainable marrow iron stores before and after parenteral iron therapy in children.


Prevalence of leukonychia in healthy female children.


Antibiotics in pediatric practice.

Antibiotics in pediatric practice.


Agonal physiology and blood gas tensions.


Congenital nonbullous ichthyosiform erythroderma. Report of improvement with 6-mercaptopurine.


Furazolidone and metronidazole in the treatment of giardiasis.


Acute haemolytic anaemia in typhoid fever.


Hepatic elastosis in Indian childhood cirrhosis.


A needle in the medial femoral condyle of a child.


Vitamin B 12  deficiency in infancy associated with lactose intolerance.


Amidohydrolases for N-short and long chain fatty acyl-L-amino acids from Mycobacteria.


Hallermann-Streiff syndrome.

Hallermann-Streiff syndrome.


Calf thymus lysine- and serine-rich histone. I. Tryptic peptides of succinylated and unmodified histone.


Studies on the xanthurenic acid-insulin complex. 3. Distribution of xanthurenic acid and formation of xanthurenic acid-insulin complex in serum.


Effect of magnesium ion on brain mitochondrial respiration. II. Effect of magnesium ion on uncoupled mitochondria.


Calf thymus lysine- and serine-rich histone. 3. Complete amino acid sequence and its implication for interactions of histones with DNA.


Optical diffraction studies on the structure of troponin-tropomyosin-actin paracrystals.


Calf thymus lysine- and serine-rich histone. II. Chymotryptic and thermolysin peptides.


Actylation of histones by a calf thymus enzyme. Studies on the sites of acetylation.


Substrate specificity of histone deacetylase from calf thymus.


Regulation of particle length of F-actin in contracted actomyosin fibers.


Threonine metabolism and its regulation in Clostridium tetanomorphum.


Sex difference in the liver and plasma free amino acid concentrations in rats.


Enzymatic formation of sulfite and acetate from sulfoacetaldehyde, a degradation product of taurine.


Acyltransferae activity to 1-acyl-, 1-O-alkenyl-, and 1-O-alkyl-glycero-3-phosphorylcholine in Ehrlich ascites tumor cells.


Chemical and physicochemical characterization of two different types of proteinase inhibitors (inhibitors II-a and II-b) from potatoes.


Comparative study on enzymatic properties of acid carboxypeptidase of molds of the genus Aspergillus.


The effect of carbodiimide blocked nucleotides on polynucleotide phosphorylase catalyzed polymerization reactions.


Calorimetric study of amylose-iodine complex formation.


Reversible inactivation of cellular thiaminase I in Bacillus thiaminolytic by thiamine and heteropyrithiamine.


A new approach to the determination of pKa's of histidine residues in proteins.


Biochemical studies on sulfate-reducing bacteria. XI. Purification and some properties of sulfite reductase, desulfoviridin.


Mode of inhibition of the Aspergillus amine oxidase by 8-hydroxyquinoline.


Studies on luciferase from Photobacterium phosphoreum. 3. Isolation and partial characterization of an enzyme-bound pigment.


Studies on erythrocyte glycolysis. 8. Kinetics of 2,3-diphosphoglycerate changes.


Studies on the substrate specificity of egg white lysozyme. IV. A comparative study of the substrate specificities of lysozymes from different sources.


Active transport of chloride by the giant neuron of the Aplysia abdominal ganglion. Internal chloride activity, a(i) (Cl), and membrane potential, E(m), were measured simultaneously in 120 R2 giant neurons of Aplysia californica. a(i) (Cl) was 37.0 +/- 0.8 mM, E(m) was -49.3 +/- 0.4 mv, and E(Cl) calculated using the Nernst equation was -56.2 +/- 0.5 mv. Such values were maintained for as long as 6 hr of continuous recording in untreated neurons. Cooling to 1 degrees -4 degrees C caused a(i) (Cl) to increase at such a rate that 30-80 min after cooling began, E(Cl) equalled E(m). The two then remained equal for as long as 6 hr. Rewarming to 20 degrees C caused a(i) (Cl) to decline, and E(Cl) became more negative than E(m) once again. Exposure to 100 mM K(+)-artificial seawater caused a rapid increase of a(i) (Cl). Upon return to control seawater, a(i) (Cl) declined despite an unfavorable electrochemical gradient and returned to its control values. Therefore, we conclude that chloride is actively transported out of this neuron. The effects of ouabain and 2,4-dinitrophenol were consistent with a partial inhibitory effect. Chloride permeability calculated from net chloride flux using the constant field equation ranged from 4.0 to 36 x 10(-8) cm/sec.


Active transport of potassium by the giant neuron of the aplysia abdominal ganglion. We measured the internal potassium activity, a(i) (K), and membrane potential, E(m), simultaneously in 111 R2 giant neurons of Aplysia californica. a(i) (K) was 165.3 +/- 3.4 mM, E(m) was -47.8 +/- 0.9 mv, and E(K) calculated using the Nernst equation was -76.9 +/- 0.05 mv. Such values were maintained for as long as 6 hr of continuous recording in untreated cells, a(i) (K) fell exponentially after the following treatments: cooling to 0.5 degrees -4 degrees C, ouabain, zero external potassium, 2,4-dinitrophenol, and cyanide. The effects of cooling and zero potassium were reversible. Potassium permeability was calculated from net potassium flux using the constant field equation and ranged from 2.6 to 18.5 x 10(-8) cm/sec. We conclude that potassium is actively transported into this neuron against a 30-40 mv electrochemical gradient.


The effects of sodium and potassium on ouabain binding by human erythrocytes. Ouabain binding by the human erythrocyte membrane is reversible, exhibits a high degree of chemical specificity, and can be detected at ouabain concentrations as low as 1 x 10(-10)M. The relation between ouabain binding and ouabain concentration can be described by a rectangular hyperbola permitting determination of the maximal binding (B(max)) and the ouabain concentration at which ouabain binding is half-maximal (K(B)). Reducing the external sodium concentration increased K(B), while reducing the external potassium concentration decreased K(B). Neither cation altered B(max) The reciprocal of K(B) was a linear function of the sodium concentration at sodium concentrations ranging from 0 to 150 mM. Conversely, the relation between the reciprocal of K(B) and the external potassium concentration was nonlinear, and raising the potassium concentration above 4 mM produced no further increase in K(B). These results are compatible with a model which postulates that the erythrocyte membrane contains a finite number of receptors each composed of a glycoside-binding site and a cation-binding site. When sodium occupies the cation-binding site, the affinity of the glycoside site for ouabain is increased; when potassium occupies the cation-binding site the affinity of the glycoside site for ouabain is decreased.


Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. Internal Cs(+), Na(+), Li(+), and, to a lesser degree, Rb(+) interfere with outward current through the K pores in voltage clamped squid axons. Addition of 100 mM NaF to the perfusion medium cuts outward current for large depolarizations about in half, and causes negative conductance over a range of membrane voltages. For example, suddenly reducing membrane potential from +100 to +60 mv increases the magnitude of the outward current. Internal Cs(+) and, to a small extent, Li(+), also cause negative conductance. Na(+) ions permeate at least 17 times less well through the K pores than K(+), and Cs(+) does not permeate measurably. The results strongly suggest that K pores have a wide and not very selective inner mouth, which accepts K(+), Na(+), Li(+), Cs(+), tetraethylammonium ion (TEA(+)), and other ions. The diameter of the mouth must be at least 8 A, which is the diameter of a TEA(+) ion. K(+) ions in the mouths probably have full hydration shells. The remainder of the pore is postulated to be 2.6-3.0 A in diameter, large enough for K(+) and Rb(+) but too small for Cs(+) and TEA(+). We postulate that Na(+) ions do not enter the narrower part of the pore because they are too small to fit well in the coordination cages provided by the pore as replacements for the water molecules surrounding an ion.


The renaissance of general practice.

The renaissance of general practice.


The treatment of non-tuberculous chest infections.


What's new in tuberculosis.

What's new in tuberculosis.


Towards a hospital disinfectant policy.

Towards a hospital disinfectant policy.


Cardiac pacing in acute myocardial infarction.


The hybrid reeler mouse.

The hybrid reeler mouse.


Genetics of ebony, a nonlethal recessive melanotic mutant in a mosquito.


A radiation-induced paracentric inversion in Aedes aegypti (L.). Cytogenetic and interchromosomal effects.


A familial occurrence of multiple polyposis.


Diurnal changes in sympathetic nerve endings in the mouse pineal: semiquantitative electron microscopic observations.


Reduction in recombination due to a deletion in a colony of wild mice.


Light and electron microscopic studies of normal and heterogeneously regenerated ganglionic synapses of the dog.


Idiopathic Parkinsonism as a late complication of encephalitis.


A pestilence of people.

A pestilence of people.


Complications of umbilical vessel catheters.


A survey on attitudes to family planning among 360 Brisbane women.


Atresia of the ears and associated multisystem anomalies. Report of two unusual cases.


The family doctor in the health team.

The family doctor in the health team.


"Bag squeezing": a physiotherapeutic technique.


The passage per anum of small bowel through a tear in a rectal prolapse.


Epithelial inclusion cysts in axillary nodes associated with malignant disease.


Leprosy and Australia.

Leprosy and Australia.


Give them a fair go, mates.

Give them a fair go, mates.


Problems of leprosy reconstructive surgery in Australia.


Abortion law.

Abortion law.


Development and manufacture of bioinstruments in India.


System planning and maintenance in developing countries.


Biomedical engineering in West Germany.

Biomedical engineering in West Germany.


UNIDO. The role of Unido in biomedical engineering.


Cystic fibrosis: lysosomal and mitochondrial enzyme activities of lymphoid cell lines.


Changes in the diameter of microtubules connected with the autonomous rotary motion of the lipotubuloids (elaioplasts).


Intraluminal and mucosal starch digestion in congenital deficiency of intestinal sucrase and isomaltase activities.


Ribosomes of Dunaliella. II. Ribosomal ribonucleic acids.


Brain hexokinase effect of ATP and localization in mitochondria.


Experimental inhibition of cell wall formation and of reversion in Nadsonia elongata and Schizosaccharomyces pombe protoplasts.


Membrane characteristics as revealed by water and ionic relations of algal cells.


Morphological and histochemical studies on the giant neurons of the reticular formation of some laboratory mammals.


Bacterial flagella rotate and do not contract.


Cerebral proteins in experimental cyanide encephalopathy.


The physiological significance of the Hill parameter 'n'.


Atypical pyruvate kinase in a family with spherocytic haemolytic anaemia.


The effect of acetylsalicylic acid and dipyridamole on platelet economy in metastatic cancer.


Fibrinolytic activity of human synovial membranes in health and in haemophilia.


Haemoglobin M Saskatoon with slight constant haemolysis, markedly increased by sulphonamides.


Ultrastructural studies of platelet 'activation' and aggregation in normal spleen from different species.


Chromosomal damage induced by chlorambucil in chronic lymphocytic leukaemia.


Quantity of diagnostic blood sampling and its clinical relevance.


Leuco-erythroblastic anaemia in prostatic cancer. Report of two cases with complete haematological remission.


Platelet refractory state induced by heparin.


The olivo-cochlear tract in the rat and its bearing on the homologies of some constituent cell groups of the mammalian superior olivary complex: a thiocholine study.


The nature of the reticulum cell of the bone marrow of the rat: an electron microscopic study of the effects of methotrexate.


The thymus of marmots: spontaneous, natural seasonal thymectomy?


Innervation of the hepatic vein sphinctes.


Isolation and properties of proteolytic enzymes of Streptomyces erythreus. I. Isolation of crude enzyme preparation.


Are anaesthetic gases harmful to operating theatre staff?


Trends in stomach cancer incidence for male cohorts in Finland.


Effect of oxyphenbutazone on liver function in man.


Halothane and nitrous oxide in end-tidal air and venous blood of surgical personnel.


Chronic exposure to anaesthetic gases in the operating theatre and recovery room.


Histocompatibility (HL-A) antigens associated with myasthenia gravis. A preliminary report.


Challenge test. Suggested method for pharmaceutical preparations.


Total and organic mercury in marine fish.


Factors influencing translocation and transformation of mercury in river sediment.


Total mercury-monomethylmercury content of several species of fish.


Dieldrin levels in relation to total, neutral, and phospholipid composition in selected pork muscles.


Lead: levels in roadside invertebrates and small mammals.


Gas chromatographic determination of pentachlorophenol in human blood and urine.


Effects of some organophosphorus insecticides on vitamin E and other blood constituents and on the apparent inducement of diarrhea in neonatal calves.


Effect of one polychlorinated biphenyl on size and activity of the gull thyroid.


Serum vitamin A elevation in DDT exposed volunteers.


A conceptual model for the study of the health action process.


The prevention of rheumatic fever.

The prevention of rheumatic fever.


Food poisoning due to Vibrio parahaemolyticus.


Temperature of storage of potentially hazardous food in Canada--an appeal for uniform regulations.


Investigation of exposure to risk factors among young drivers (16-25 years) 1969-1971.


Current trends in antimicrobial therapy.


McMaster field unit; an experiment in mental health consultation.


Management of acute myocardial infarction in general practice.


A study of dental care cost, time and treatment requirements of older persons in the community.


A new look in public health nursing.

A new look in public health nursing.


Children in child welfare agencies: a model for more effective delivery of medical and psychiatric services.


Severe Mycobacterium kansasii infection of the lung.


Quality in health care.

Quality in health care.


The challenge of life. Biomedical progress and human values. Roche anniversary symposium. Roche and the human problems of biomedical progress.


A rural nutrition clinic in Ghana.

A rural nutrition clinic in Ghana.


Newer knowledge of immunobiology and its applications.


Vancouver's innovative project in dental health care.


The challenge of life. Biomedical progress and human values. Roche anniversary symposium. Introduction to the symposium--an outline of its scope and limitations.


Changing life patterns and the consciousness of the individual.


Comments on the drug abuse problem.

Comments on the drug abuse problem.


Indoor versus outdoor air pollution.

Indoor versus outdoor air pollution.


Shifting targets for our magic bullets.

Shifting targets for our magic bullets.


Experimenting with humans: problems and processes of social control in the biomedical research community.


Health as the physician views it, and the use of space technology to achieve and maintain it.


The doctor's dilemma. The right to health. Choices and priorities in research and development in the biomedical field.


The problem of relieving the physician of unnecessary burdens.


The identity and origin of antigens in human semen.


A new approach for evaluation of the spermatogenic function using radiozinc.


In vitro fertilization of rabbit ova recovered from ovarian follicles.


Uterine activity during and after mating in the rabbit.


Triplet pregnancy and cervical incompetence. A case report.


Neuroma and neurosis in the hand.

Neuroma and neurosis in the hand.


Lateral instability at the metacarpophalangeal joint of the thumb.


Tourniquet in reconstructive surgery of the hand.


Optical and thermal effects on thermoluminescence response of Mg 2 SiO 4 (Tb) and CaSo 4 (Tm) phosphors.


Lithium fluoride glow-peak growth due to annealing.


Radiation exposure measurements in the 8-15 kVp X-ray range.


Calculation of the dose, radionuclide production and delayed photon leakage due to solar-proton bombardment of tissue with potential application to astronaut dosimetry.


Quantities for the description of neutron irradiations of man. A look at the mechanism of over-conservatism.


Radiation levels and fluence conversion factors.


Aspects of radiation control for clinical implants of Californium-252.


Profile and educational opportunities of health physics technicians.


Long-term study of the urinary Strontium-90 and calcium in children.


Sodium-22 in the food-chain: lichen-reindeer-man.


Metabolism of monomeric and polymeric plutonium in the rabbit; comparison with the mouse.


A paint to reduce  41 Ar release and residual activity in a reactor exposure volume.


Human faecal  226 Ra excretion shortly after a RaSO 4  dust contamination, with alginate treatment.


Estimation of sulphur content in human hair and nail for use in fast neutron dosimetry.


A 5-10 MeV portable photon survey meter.


Measurement of mean quality factor by LET spectroscopy.


An approximate relation for the prediction of the dose rate from radioactivity induced in high energy particle accelerators.


An inexpensive TLD personnel badge.

An inexpensive TLD personnel badge.


Ventilation of electron capture detectors.


Recurrent varicose veins after stripping.


The hypotensive response to amphetamine after completion of tachyphylaxis.


A note on a reliable distinguishing feature between the two closely allied scrub-typhus vectors, Leptotrombidium (L.) deliense and L (L) Akamushi.


Some observations on spinal epidural hematoma.


Intrathoracic mesotheliomas associated with tuberculosis.


Behaviour problems of children.

Behaviour problems of children.


Obstructive jaundice with amebic liver abscess.


Incidence of urinary disorders in north-west Rajasthan and South Punjab, India; a study based on 1,500 intravenous pyelograms.


Some observations on Hatha Yoga: the Bandhas: an anatomical study.


Use of propranolol to differentiate between organic and functional ST-T changes in the electrocardiogram.


Why the downfall? An introspection by a general practitioner.


Cardiovascular disease prevention--habits of youth set pattern.


Variations in the pattern of maternal serum vitamin A and carotenoids during human reproduction.


Effect of dietary selenium on the gastrointestinal absorption of ( 75 SeO3)2- in the rat.


Not Pygmalion likely (Rushton v. Higgins).


Fatal paraquat poisoning in Northern Ireland.


Sodium chlorate poisoning.

Sodium chlorate poisoning.


Examination of small quantities of lipsticks.


Characterization of candle-waxes by differential thermal analysis.


The identification of foetal haemoglobin in bloodstains.


The examination of cystolithic hairs of Cannabis and other plants by means of the scanning electron microscope.


Procedure for the preparation of milligram quantities of adenovirus messenger ribonucleic acid. Late after adenovirus 2 infection (18 hr), nearly all newly synthesized polysomal messenger ribonucleic acid (mRNA) is viral specified. Large amounts of adenovirus mRNA have been purified by utilizing membrane filtration at high ionic strength. With this procedure, molecules that contain polyadenylic acid [poly (A)] tracts are bound selectively, and ribosomal RNA can be separated from the viral mRNA which contains poly(A). Polysomal RNA synthesized 18 hr after infection was labeled in the presence of 0.02 mug of actinomycin D per ml and extracted at pH 9.0. This RNA annealed 40% to 3 mug of adenovirus 2 deoxyribonucleic acid; the RNA selected by membrane filtration bound 80% under the same conditions. The RNA eluted from membrane filters was 80 to 90% greater than 18S and contained species migrating as 31, 27, and 24S. Binding of polysomal RNA to individual membrane filters was linear, using as much as 300 mug of RNA per membrane. A 1.1-mg amount of viral RNA was prepared from 17.7 mg of polysomal RNA that had been purified by extraction at pH 9.0.


Acquired ichthyosis.

Acquired ichthyosis.


Cell fusion by canine distemper virus-infected cells. AV3 cells (continuous human amnion) infected with the Onderstepoort strain of canine distemper virus produced cell fusion within 2 to 5 hr when added to AV3 cell monolayers. An apparent requirement for intact, infected cells was demonstrated by showing that (i) frozen-and-thawed infected cells failed to induce fusion, (ii) infected cells frozen in the presence of glycerol retained their ability to induce fusion, (iii) infected cells subjected to swelling in hypotonic buffer and homogenization lost their ability to fuse cells, and (iv) semipurified and concentrated virus preparations with infectivity titers as high as 10(7.5) mean tissue culture doses per ml failed to induce fusion within 5 hr. Preparations of intact, infected cells had a mean log(10) ratio of infectivity to fusion activity of 3.6. Treatment with beta-propiolactone rendered the active preparations free from detectable infectivity while they retained their ability to cause cell fusion. Cycloheximide did not block the formation of syncytia in assay cells. This type of cell fusion was neutralized by canine distemper virus immune antisera, and measles virus immune sera showed a slight degree of cross-neutralization. Other cell lines, HEp-2, MA 139 (embryonic ferret lung), MA 104 (embryonic rhesus monkey kidney), and Vero (African green monkey kidney) were also susceptible.


Histoplasmosis: further reports.

Histoplasmosis: further reports.


Vasovagal reactions in blood donors.

Vasovagal reactions in blood donors.


Pyloric obstruction due to ingestion of corrosives.


Air splints used as immediate postoperative prostheses after long posterior flap below-knee amputation.


Fatalities due to the weed-killer paraquat.


Problems of a head-injury patient.

Problems of a head-injury patient.


An overview of the analysis and interpretation of bioavailability studies in man.


Physiological and pharmacokinetic complexities in bioavailability testing.


Phenylbutazone.

Phenylbutazone.


Newer physicochemical methods useful in bioavailability studies.


Sodium warfarin.

Sodium warfarin.


Biopharmaceutics of nitrofurantoin.

Biopharmaceutics of nitrofurantoin.


Pharmaceutical industry.

Pharmaceutical industry.


Canadian experience.

Canadian experience.


The official compendia.

The official compendia.


The profession of pharmacy.

The profession of pharmacy.


The profession of medicine.

The profession of medicine.


Mechanisms of drug absorption and of drug solution.


Bioavailability, clinical effectiveness, and the public interest.


Anticancer agents. VII. Derivatives of pyruvaldehyde and ethylpyruvaldehyde.


Design of in vivo studies of bioavailability--biometrical considerations.


Serial changes in CO 2  storage in tissues.


A psychoendocrine study of bereavement. II. Observations on the process of mourning in relation to adrenocortical function.


Displacements of the lung hilum, pleural surface pressure and alveolar morphology.


Factors influencing adjustment of burn patients during hospitalization.


The response of the respiratory system to elastic loading in cats.


The role of the vagus nerves, peripheral chemoreceptors and other afferent pathways in the genesis of augmented breaths in cats and rabbits.


A longitudinal study of 21 subjects with coronary heart disease: life changes, catecholamine excretion and related biochemical reactions.


The effect of CO 2  upon discharge from slowly adapting stretch receptors in the lungs of rabbits.


Pulmonary mechanoreceptor fibres in the vagus of the domestic fowl.


A psychoendocrine study of bereavement. I. 17-Hydroxycorticosteroid excretion rates of parents following death of their children from leukemia.


The Schedule of Recent Experiences. A reliability study.


The diameter of red blood cells when flowing through a rapid reaction apparatus.


Dynamic aspects of regulation of ventilation in man during acclimatization to high altitude.


Life stress and illness patterns in the US Navy. VI. Environmental, demographic, and prior life change variables in relation to illness onset in naval aviators during a combat cruise.


Control of exercise hyperpnea under varying durations of exposure to moderate hypoxia.


The problem of brain stem injury with special reference to serial EEG studies, long-term rehabilitation and results.


Mental disorders in the early stage of brain injury.


The effects of maternal separation, isolation and sex on the response to Ehrlich carcinoma in BALB-c mice.


Neck injuries in road accidents. Incidences of acute injuries and sequelae among in-patients.


The importance for rehabilitation of the interbody fusion and stabilization operation in fracture dislocations of the cervical spine.


Epilepsy and driver's licence-some comments.


Vestibular and medico-legal aspects of closed cranio-cervical trauma.


Comparison of effects from single and repeated trauma to the animal brain.


Organisation of medical resources for rehabilitation in neurological diseases.


Pain tolerance: differences according to age, sex and race.


Effect of carbon tetrachloride-induced liver damage on organic ion transport in rat liver.


Acute toxicity on dimethyl 4,4'-o-phenylene bis(3-thioallophanate), thiophanate-methyl fungicide.


Modification of the effects of   9 -tetrahydrocannabinol by phenobarbital pretreatment in mice.


Some pharmacologic properties of a new fungicide thiophanate-methyl.


Electroencephalographic study of L-glutamate induced seizures in rats.


The nephrotoxicity of single and multiple doses of aliphatic chlorinated hydrocarbon solvents in male mice.


Inhibition of subcellular cholinesterases by 2-carbomethoxy-l-methylvinyl dimethyl phosphate (mevinphos) in vitro and in vivo.


Acute cardiovascular, antiarrhythmic and toxic effects of tetrodotoxin (TTX) in unanesthetized dogs.


Potentiating effects of chlorpromazine on the paralysis and toxicity induced by guaiacal glyceryl ether in rats.