Timing of spermatogenesis in four nonhuman primate species.


A technique for fixation of chronically implanted catheters in unrestrained primates.


Ossification in the thyrohyoid ligament with "joint" formation. A case report.


Detection of type-specific pneumococcal antigens by counterimmunoelectrophoresis. I. Methodology and immunologic properties of pneumococcal antigens.


Nonspecific stimulation and modulation of the immune response and of states of resistance by the methanol-extraction residue fraction of tubercle bacilli.


Immunologic evaluation of the cancer patient during immunotherapy.


Early functional mutants of mammalian cells.


Cell autonomous lethals in Drosophila melanogaster.


The properties of ribonucleases isolated from urine of patients with chronic granulocytic leukemia. I. Urinary alkaline ribonuclease.


Multiple myeloma of IgD class.

Multiple myeloma of IgD class.


Content of free amino acids in red blood cells and blood plasma of children with protein and caloric deficiency.


Ethacrynate-induced depression of respiration in transport systems and kidney mitochondria.


Isolation of apoproteins from canine surface active material.


A spectrophotometric method for the determination of the catecholase activity of tyrosinase by Besthorn's hydrazone.


Hydrophobic affinity chromatography of proteins.


Survival of airborne Pasteurella tularensis at different atmospheric temperatures. The aerosol survival, recovery, and death rate of Pasteurella tularensis SCHU S5 disseminated in particle sizes of 1 to 5 mum were significantly affected by air temperature. The highest aerosol recovery of viable P. tularensis was observed within -7 and 3 C; the recovery decreased significantly below and above this temperature range. The death rate of airborne P. tularensis was not significantly influenced by an increase in temperature from -40 to 24 C. However, a progressive increase in atmospheric temperature from 24 to 35 C resulted in increased death rates; thus, a linear relationship appeared to be present between the temperature and death rates. At 49 C, the recoveries of viable airborne P. tularensis were significantly lower and the death rates were higher than at the other temperatures.


Immune response in primates vaccinated with duck embryo cell culture rabies vaccine. Adult rhesus monkeys (Macaca mulata) were vaccinated with four inactivated rabies vaccines, including two cell culture vaccines, one zonal purified cell culture vaccine, and a 10% extracted duck embryo vaccine. The vaccines were potency tested by both National Institutes of Health (NIH) and Habel methods and passed one or both tests. However, a vaccine having acceptable potency by one method frequently failed or was marginal by the other procedure. Groups of three monkeys were inoculated with each vaccine by one of two schedules. The first consisted of four weekly 1-ml doses followed by a 1-ml booster dose at 6 months, and the second consisted of seven daily 1-ml doses of vaccine with no booster. Both zonal purified and extracted duck embryo vaccines induced detectable neutralizing antibody by day 7 with either schedule, and antibody titers elicited by the cell culture vaccine remained high through 210 days. However, antibody titers produced by the 10% duck embryo vaccine dropped sharply after their 28-day peak. Duck embryo cell culture vaccines with low or marginal potency as measured by Habel or NIH tests still produced rapid, high levels of serum-neutralizing antibody in primates. LD(50) or NIH and Habel tests as measured in mice were not necessarily good indices of antibody response in the primate host. The need for a cell culture potency test that will yield a more predictable correlation with the definitive host's antibody response is discussed.


-D-phosphogalactoside galactohydrolase of lactic streptococci. beta-D-Phosphogalactoside galactohydrolase (beta-Pgal) was examined in a number of lactic streptococci by use of the chromogenic substrate o-nitrophenyl-beta-D-galactopyranoside-6-phosphate. Specific activity of beta-Pgal ranged from 0.563 units/mg of protein in Streptococcus lactis UN, to 0.120 in S. diacetilactics 18-16. Essentially no beta-D-galactoside galactohydrolase (beta-gal) was found in these organisms when o-nitrophenyl-beta-D-galactopyranoside served as the chromogenic substrate. S. lactis 7962 was the one exception found. This organism contained rather high levels of beta-gal, and very little beta-Pgal could be detected. beta-Pgal activity was examined in streptococci that differed widely in both their proteolytic ability and rates of lactic acid production during growth in milk. Differences in proteolytic ability did not influence beta-Pgal synthesis; also, the rate of lactic acid production was independent of the level of beta-Pgal present in the cell, since the rate of lactic acid production could be increased approximately fourfold without changing the amount of beta-Pgal present in the cell. Various carbohydrates were tested as potential inducers of the enzyme. Although galactose, either as the free sugar or combined with glucose in lactose, was the only inducer, noninducing sugars such as mannose or glucose showed some ability to cause fluctuations in the basal level of beta-Pgal. Cells growing in mannose or glucose exhibited about 30% of the maximal enzyme levels found in cells growing in lactose or galactose. No gratuitous inducers were found.


Location and consequences of 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane uptake by Bacillus megaterium. No detrimental effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) were observed when cells of Bacillus megaterium were grown from small inocula in nutrient media containing up to 100 mug of DDT/ml. However, when the ratio of DDT to biomass of resting cells was held constant, levels of DDT as low as 1 mug/ml (0.5 mug/mg of cell dry weight) enhanced the rate of death in the population. The lethal action of DDT was both time- and dose-dependent so that higher doses required less time to effect the same killing than did lower doses. Intact cells bound a maximum of about 1.7 mug of DDT/mg of cell dry weight, of which about 75% was localized in the protoplast membrane. Much of the bound DDT was subsequently lost to the suspending medium and the aqueous stability of the returned DDT was enhanced, possibly by association with solubilized cell materials. A small quantity of bound DDT was converted to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane, which was released from cells somewhat faster than DDT. Apparently the lethal action of DDT was related to its binding in the membrane, but respiration was not inhibited. The atypical macroscopic appearance of membranes isolated from treated cells suggested that cell death may result from altered membrane chemistry.


Fractionation of dipeptidase activities of Streptococcus lactis and dipeptidase specificity of some lactic acid bacteria. Proteins in sonic extracts of Streptococcus lactis were separated by starch-gel electrophoresis at high voltage. Each slab was sliced longitudinally, and half was stained for peptidases in a mixture containing a peptide, L-amino acid oxidase (snake venom), peroxidase, and o-dianisdine; the other half was stained in amido black for protein. In addition to sonic treatment, trypsin also released enzyme from acetone-treated cells. Glycyl-L-phenylalanine, L-phenylalanyl-glycine, L-alanyl-L-phenylalanine, and L-phenylalanyl-L-alanine served as substrates in characterizing the enzymes. Five different fractions of various specificities appeared in the gels. Broad-range substrate specificities were found for sonic extracts of S. lactis, S. cremoris, S. durans, and Lactobacillus acidophilus.


Determination of endotoxicity in bacterial vaccines. Endotoxicity of bacterial vaccines was quantitated in mice by using actinomycin D as potentiating agent. The results were compared with those obtained by the mouse weight gain test. The lethality of Escherichia coli lipopolysaccharide was increased 2,140 times when 12.5 mug of actinomycin D was used. The mean lethal dose values of heated and unheated pertussis vaccines were similar in the actinomycin D enhancement assay, but the unheated vaccine was significantly more toxic in the mouse weight gain test. Acetone-inactivated typhoid vaccine was slightly less toxic than the heat-phenol-inactivated vaccine in both the actinomycin D enhancement assay and mouse weight gain test. Endotoxicity of experimental vaccines prepared by extraction of Pseudomonas aeruginosa strains was high as compared with E. coli lipopolysaccharide. The BALB/c mice were about four times more susceptible than the random bred NIH strain mice. The results indicate that the actinomycin D enhancement assay had the advantages of being more sensitive and probably more specific.


Quantitative detection of type A staphylococcal enterotoxin by Laurell electroimmunodiffusion. The detection of staphylococcal enterotoxin A by the quantitative technique of electroimmunodiffusion is described. High dilutions of type-specific rabbit antiserum were used in 1% agarose gels, 1 mm thick, and prepared in 0.05-mug barbital buffer, pH 8.6. Volumes of 10 muliters containing 1.5 to 10 ng of toxin were electrophoresed out of 4-mm diameter wells at 5 mA/cm width of gel. The precipitin cones formed were made visible by first immersing the agarose gels in 0.2 M NaCl and then overlaying the surface with the purified globulin fraction of sheep serum against rabbit globulin, followed by soaking of the gels in 1% aqueous cadmium acetate and staining with 0.1% thiazine red in 1% glacial acetic acid. Fully extended cones, 4 to 23 mm in length depending on toxin concentration and antiserum dilution, were developed in 2 to 5 h of electrophoresis, and visualization was achieved within 2 to 3 h. Because the method is qualitative, quantitative, simple, rapid, and sensitive, it offers a practical tool for the detection of small amounts of bacterial toxins in contaminated foods. The method should also qualify as a sensitive detection device in biochemical procedures which attempt to trace, detect, and identify biological substances in nanogram quantities, provided these substances are antigenic and capable of forming a precipitate with their specific antibodies.


Nursery outbreak of Pseudomonas aeruginosa: epidemiological conclusions from five different typing methods. In April 1971, nine cases of Pseudomonas aeruginosa septicemia occurred in a high-risk nursery. The epidemiology of the outbreak was studied by pyocin production, pyocin sensitivity, serological typing, antibiotic susceptibility, and phenotypic properties such as colonial morphology, pigment, and hemolysis. Ten isolates of P. aeruginosa were recovered from 9 newborn infants and from 13 environmental sources. Twenty-one of the 23 isolates had identical pyocin production patterns against 60 different indicator strains and were of the same serotype. These 21 isolates were designated as the "outbreak strain"; the other 2 isolates had no epidemiological significance. The results of pyocin sensitivity, antibiotic susceptibility tests, and phenotypic properties were dissimilar. They would yield incorrect epidemiological conclusions if used alone. The outbreak strain dissociated in vitro and these phenotypic changes accounted for the variable results by the latter three typing methods. Although the precise mode of introduction of the organism into the nursery could not be determined in retrospect, the epidemiological data strongly suggested that one infant contracted a P. aeruginosa infection, and this strain spread throughout the nursery by means of contaminated resuscitation equipment.


Effect of selected lactic acid bacteria on growth of Staphylococcus aureus and production of enterotoxin. Representative strains of 15 species of lactic acid bacteria were examined for their ability to influence growth of Staphylococcus aureus and production of enterotoxin in associative culture. Among the organisms used as effectors the streptococci were most inhibitory, followed by Pediococcus cerevisiae. The lactobacilli and Leuconostoc citrovorum were not inhibitory to growth and only slightly inhibitory to production of enterotoxin. Enterotoxin was detected in all cultures in which the population of S. aureus reached 8 x 10(7) per ml. At lower S. aureus populations no enterotoxin was detected after incubation for 48 h. Mechanisms of inhibition of growth and enterotoxin production by S. aureus strain 243 grown in association with Streptococcus lactis A64 or P. cerevisiae 10791 in APT broth were investigated. Competition for vital nutrients, especially niacin and biotin, and probably production of hydrogen peroxide contribute to inhibition. Production of lactic acid appears to inhibit growth of S. aureus in the early but not the late stages of incubation.


Factors affecting the growth of Pseudomonas fluorescens in liquid egg white. Pseudomonas fluorescens grew rapidly in fresh egg albumen diluted with water. Growth of the bacteria in egg albumen was stimulated by the addition of carbohydrate and ovomucoid-rich egg exudate. Polyacrylamide-gel electrophoresis for residual egg albumen revealed extensive proteolysis of albumen inoculated with the organism. A fluorescent compound with absorption maximum at 408 nm was isolated from a defined salt medium inoculated with P. fluorescens. It shortened the lag phase and increased the final cell yield of the organism when added to the salt medium (100 mug/ml).


Cytological and deoxyribonucleic acid-deoxyribonucleic acid hybridization studies on lactobacillus isolates from San Francisco sourdough. Molecular taxonomic and electron microscopy studies were performed on four bacterial isolates obtained from different sources of San Francisco sourdough (SD). These bacteria were first isolated by Kline and Sugihara who tentatively described them as a previously unreported species of heterofermentative Lactobacillus; they suggested the name Lactobacillus sanfrancisco. The guanine plus cytosine base composition (%GC) of the deoxyribonucleic acid (DNA) ranged from 38 to 40%. The possible genetic relatedness of these SD isolates to five known species of Lactobacillus with comparable GC contents was assessed in the present work by means of DNA-DNA hybridization competition experiments. Little or no DNA homology was observed between the SD bacteria and the known species. The SD bacteria exhibited a high degree of homology (>88%) among themselves, suggesting that the four isolates were identical taxonomically. Also, the electron photomicrographs revealed structures similar to those of gram-positive bacilli. Accordingly, since these SD isolates have the characteristic phenotypic and morphological properties of the genus Lactobacillus and are not related genetically to any known species, the tentative characterization by the above workers of these isolates as a new species is substantiated.


Demonstration of a deoxycytidine kinase activity in extracts of Bacillus megaterium KM. Extracts of Bacillus megaterium KM have been shown to possess a deoxycytidine kinase activity which functions optimally with guanosine triphosphate as the phosphoryl donor.


Clinical correlations with immunoglobulin levels in chronic lymphatic leukaemia.


Effect of synthetic thyrotrophin releasing hormone (TRH) in man.


Experimental immunization against human placental antigens.


Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution.


Radiosensitizing property of butylated hydroxytoluene in Drosophila sperm.


Pseudomonas aeruginosa: its complications in the lower extremity. Case presentations and discussion.


Lysosomal physiology in Tetrahymena. I. Effect of glucose, acetate, pyruvate, and carmine on intracellular content and extracellular release of three acid hydrolases. Log-phase Tetrahymena were washed and resuspended in a dilute salt solution supplemented with glucose, acetate, pyruvate, or carmine, as desired, and then incubated for 5 h. Intra- and extracellular activities of acid phosphatase, alpha-glucosidase, and ribonuclease were assayed. Extracellular activities were corrected for proteolytic degradation. The three nutritive substrates affected both the amount and pattern of extracellular enzyme release, but carmine had no effect. Intracellular activities declined early in the starvation period, but partially recovered with time, particularly alpha-glucosidase activity. Acetate reduced the decline in acid phosphatase activity; acetate and glucose enhanced the recovery of alpha-glucosidase activity; carmine had no effect on intracellular enzyme activities. Protein content changed little and was unaffected by the addition of substrates. Glycogen content increased during incubation; acetate and glucose enhanced the increase.


Vitamin B 12  and the macromolecular composition of Euglena. II. Recovery from unbalanced growth induced by Vitamin B 12  deficiency. When vitamin B(12) is added to B(12)-deficient cultures of Euglena gracilis, the cells undergo two relatively synchronous cell divisions within a shorter than usual period of time, apparently as a result of a transitory shortening of the cell cycle. The first cell division pulse, occurring 4.5 h after addition of B(12), is preceded by the completion of DNA duplication, but appears to involve no net synthesis of RNA or protein. Before the second round of cell division at about 11 h, a significant amount of DNA synthesis is observed. This time it is accompanied by a minor increase in the RNA and protein content of the culture. The cellular contents of RNA and protein were observed to decrease steadily after the resumption of cell division in B(12)-depleted cultures receiving the vitamin. Ultimately all three macromolecules returned to their nondeficient, plateau stage levels; by this time, cell division had ceased.


The contractile process in the ciliate, Stentor coeruleus. I. The role of microtubules and filaments. The structural basis for the function of microtubules and filaments in cell body contractility in the ciliate Stentor coeruleus was investigated. Cells in the extended state were obtained for ultrastructural analysis by treatment before fixation with a solution containing 10 mM EGTA, 50-80 mM Tris, 3 mM MgSO(4), 7.5 mM NH(4)Cl, 10 mM phosphate buffer (pH 7.1). The response of Stentor to changes in the divalent cation concentrations in this solution suggests that Ca(+2) and Mg(+2) are physiologically important in the regulation of ciliate contractility. The generation of motive force for changes in cell length in Stentor resides in two distinct longitudinal cortical fiber systems, the km fibers and myonemes. Cyclic changes in cell length are associated with (a) the relative sliding of parallel, overlapping microtubule ribbons in the km fibers, and (b) a distinct alteration in the structure of the contractile filaments constituting the myonemes. The microtubule and filament systems are distinguished functionally as antagonistic contractile elements. The development of motive force for cell extension is accomplished by active microtubule-to-microtubule sliding generated by specific intertubule bridges. Evidence is presented which suggests that active shortening of contractile filaments, reflected in a reversible structural transformation of dense 4-nm filaments to tubular 10-12-nm filaments, provides the basis for rapid cell contraction.


The connections between bipolar cells and photoreceptors in the retina of the domestic cat.


Traumatic pharyngeal pseudodiverticulum in the newborn infant.


Studies on histone fraction F2A1 in macro- and micronuclei of Tetrahymena pyriformis. Histone fraction F2A1 has been isolated and purified from macronuclei of the ciliate Tetrahymena pyriformis. It migrates as a single species on sodium dodecyl sulphate-acrylamide gel electrophoresis, with a molecular weight indistinguishable from that of calf thymus F2A1. The solubility properties of Tetrahymena F2A1 are also similar to those of calf thymus F2A1. Electrophoretic analyses on urea-acrylamide gels indicate that Tetrahymena F2A1 consists of four or five subspecies, the two fastest having electrophoretic mobilities identical with those of the two major electrophoretically separable forms of calf thymus F2A1. High resolution (long gel) electrophoresis coupled with incorporation of radioactive acetate both in vivo and in vitro suggest that, as in the case of calf thymus F2A1, differentical acetylation of a parent molecule can explain the observed electrophoretic heterogeneity of Tetrahymena F2A1. Electrophoretic analysis of histones isolated from the micronucleus, which is genetically less active than the macronucleus, indicates that it contains largely the relatively unacetylated (parent) form of histone F2A1.


Functioning solitary nodule of the thyroid in a child.


Intravenous alimentation in low-birth-weight infants.


Ammonia intoxication: its relevance in total parenteral alimentation.


Synthesis and antimicrobial properties of 17 -isopentyloxy-4-aza-5 -androstane and the 4-methyl derivative.


Effect of 3-phenylpropan-1-ol, 2-phenylethanol, and benzyl alcohol on Pseudomonas aeruginosa.


Metabolism of the antihypertensive agent 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylic acid diethyl ester.


Distribution of dibenzoxazepines bearing the carboxamide or other side chains in ocular and other tissues of dogs.


Kinetic assay of single nitroglycerin tablets.


Diphtheria toxin: specific competition for cell receptors.


Distribution of dimers in ultraviolet-irradiated DNA.


Step-wise changes in thermoregulatory responses to slowly changing thermal stimuli.


Screening for gonococcal arthritis.

Screening for gonococcal arthritis.


The prevention of blindness. Report of a WHO Study Group.


Central venous catheter placement utilizing common facial vein. A technic useful in hyperalimentation and venous pressure monitoring.


Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine. In rhesus monkeys a wide dosage range of 17D yellow fever (YF) vaccine extending to a level even below that recommended for vaccination of man elicited an immune response providing solid protection to challenge with virulent YF virus. Forty-three of 45 monkeys vaccinated with 10(2.3) or greater weanling mouse mean lethal doses of 17D vaccine were resistant to challenge 20 weeks later with virulent Asibi strain YF virus. Monkeys given graded doses of lesser amounts of vaccine were progressively more susceptible to challenge. With a vaccine dose >/= 10(2.3) weanling mouse mean lethal doses, plaque neutralization (PN) seroconversion rates were 90% or greater, whereas hemagglutination-inhibiting (HI) and complement-fixing (CF) seroconversion rates were unrelated to vaccine dosage and were generally in the range of 20 to 80%. Ninety-six percent (51 of 54) of immune monkeys had PN titers >/=0.7 log(10) (fivefold) neutralization index as compared to approximately 55 to 65% who showed HI or CF titers >/=2 log(2) (fourfold) neutralization index. After challenge with Asibi strain YF virus, antibody titers of all three tests increaed equally. In rhesus monkeys PN antibody titers were well correlated with YF immunity, whereas HI and CF antibody titers were not.


Rapid fermentation confirmation of Neisseria gonorrhoeae. A rapid sugar fermentation procedure has been developed for the confirmation of Neisseria gonorrhoeae from either primary isolation media or purification media. A lightly buffered salt solution with pH indicator and sugars was heavily inoculated with presumptively positive growth. Proper fermentation patterns are obtained in 1 to 4 h with no interference from inhibited contaminants or variation in results due to differing growth requirements of gonococcal strains.


Radioimmunoassay for type A toxin of Clostridium botulinum. A preparation of pure type A toxin of Clostridium botulinum was labeled with (131)I in the presence of chloramine-T and carrier-free isotope. The radioactive toxin ((131)I Tox) was used in a radioimmunoassay procedure similar to that of Berson and Yalow. Dilutions of antibody to the toxin, capable of binding 50% of the added (131)I Tox, were mixed with a sample of the labeled toxin and various concentrations of unlabeled toxin ('Cold' Tox). When concentration of Cold Tox were plotted against the ratio (131)I bound/(131)I not bound, a standard curve was established that could be used to estimate the concentration of Cold Tox in a test mixture. This assay was sensitive to as little as 100 mouse minimum lethal dose and was highly specific for the serological type of the toxin used.


Heat of combustion of cells of Pseudomonas fluorescens. Based upon 161 determinations, the heat of combustion of cells of Pseudomonas fluorescens averaged 5.32 kcal/g on an ash-free dry-weight basis. The standard deviation was 0.39 kcal.


Quantitative growth of Naegleria in axenic culture. A strain of Naegleria gruberi, isolated from a Vero cell culture and designated TS-1, was axenically cultivated in monolayer and mass aerating suspension culture. Cultural conditions for constant growth parameters and high-exponential cell densities were defined. Serum or other supplemented fractions were found essential in both Trypticase-yeast extract-glucose (TYG) and Casitone (CAS)-based media. Monolayer cultures grown in the CAS medium required lower levels of serum to reach maximum stationary densities of amoebae than cultures grown in the TYG medium. Heat-killed (121 C, 10 min) whole cell and cell lysate bacterial fractions were capable of replacing the serum in both the TYG and CAS media. Heat-killed bacterial fractions provided the same levels of growth as attained with serum in TYG medium, whereas the bacterial lysate supported only minimal growth in the same medium. In the CAS medium, both bacterial fractions resulted in the same level of growth which was equal to that obtained in reduced serum content. Strain TS-1 was established in suspension culture with the CAS medium used in monolayer culture. The addition of sheep red blood cells (RBC) or RBC lysate greatly enhanced growth responses. Further modifications resulted in a final medium for suspension culture consisting of Casitone-yeast extract-glucose-vitamin base, supplemented with serum and RBC lysate. This medium supported growth with a mean generation time of 9 h at 30 C and a stationary phase yield of greater than 5 x 10(6) amoebae per ml.


Singh's Aedes albopictus cell cultures as helper cells for the adaptation of Obodhiang and kotonkan viruses of the rabies serogroup to some vertebrat cell cultures. Multiplication of rabies serogroup viruses, Obodhiang and kotonkan, was induced in vertebrate cell cultures by using Singh's Aedes albopictus cell cultures as "helper cells."


A collagenolytic protease from the hepatopancreas of the fiddler crab, Uca pugilator. Purification and properties.


Insulin degradation. I. Purification and properties of glutathione-insulin transhydrogenase of rat liver.


Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat.


An inexpensive diversity receiving system for medical telemetry.


Yeast glycogen synthetase in the glucose 6-phosphate independent form: a case of cold lability without major changes in molecular size.


Effect of glucagon, insulin and acetylcholine on heart glycogen synthetase and phosphorylase activity.


Effects of long-term elemental nasogastric feeding on elderly debilitated patients. The effects of a liquid elemental diet on nine patients requiring nasogastric tube feeding because of severe dysphagia were studied. A casein based feeding served as a control. The elemental diet was given over a 12-week period except in the case of one man who expired after nine weeks from causes unrelated to the diet.The feeding was well tolerated by the digestive tract. Satisfactory nutrition appeared to be maintained as indicated by weight gain, stable hemoglobin, serum total protein and albumin values, and normal healing of pressure sores. BUN levels decreased significantly. Uric acid levels increased but remained within normal limits. Pancreatic function was unaffected clinically and from the postmortem findings of the man who died, pancreatic morphology was normal. Fasting blood sugars, serum electrolytes, hematocrit, bleeding, clotting and prothrombin times, and platelet counts were normal.


The effect of nicotinic acid on the synthesis of plasma lipoproteins in monkeys.


Recurrent urethritis in women.

Recurrent urethritis in women. The bacterial flora of the vestibule, urethra and vagina of a group of patients with recurrent urethritis, and of control subjects without symptoms, was investigated. Organisms regarded as pathogenic, such as enterobacteria and Streptococcus faecalis, were recovered significantly more frequently from patients than from controls, whereas the reverse was found for non-pathogenic organisms. The bacterial flora was similar in the three areas, suggesting that a specimen taken from one region only would give adequate bacteriological information. The vestibule is suggested as a suitable site. The incidence of vestibular pathogens was higher in postmenopausal patients. Perineal length and vestibular pH were very similar in patient and control groups. There was some evidence that in most subjects the bacterial flora of the areas investigated remains fairly constant over a period of several weeks. Although bacterial species commonly responsible for urinary tract infection may often cause recurrent urethritis, the absence of these pathogens from some patients suggests that the etiology of this condition is not yet fully understood.


Changes in the fine structure of the ovarian follicle of the toad (Bufo bufo) Prior to induced ovulation.


Bone metabolism and composition in the protein-deprived rat.


Activity of motor cortex neurons in association with learned movement.


Giant epiphrenic diverticulum of the esophagus.


Behavioural and neurological disturbances associated with hypoxic brain damage.


Gonadotrophin-induced multiple ovulation in the crab-eating monkey, Macaca fascicularis.


Effect of whole body radiation and hypoxia on erythropoietin production in the subhuman primate Tamarinus nigricollis.


Investigations using a whole-body scanning system with digital control and read-out.


Enteropathogenicity of some Vibrio parahaemolyticus strains in nonhuman primates.


Measurement of whole-body nitrogen by pulsed neutron activation analysis.


Idiopathic respiratory distress syndrome. Treatment with continuous negative-pressure ventilation.


Fine structure of astrocyte mitochondria in the spinal cord of the dog, cat and monkey.


Nephrosis, steroids, pancreatitis, and diabetic ketoacidosis.


Mutational alteration of Bacillus subtilis DNA polymerase 3 to hydroxyphenylazopyrimidine resistance: polymerase 3 is necessary for DNA replication.


A carotenoprotein from chromatophoreses of Rhodospirillum rubrum.


Molecular weight of a human J chain.

Molecular weight of a human J chain.


A unique IgG myeloma immunoglobulin--molecular weight and other properties.


Association of ribosomal subunits. 3. Properties of the 30 S-50 S couples produced in vitro by the association factor from Bacillus stearothermophilus.


Subunits of toxin and agglutinin of Ricinus communis.


Fetal implants in uterus.

Fetal implants in uterus.


Complement in membranoproliferative (hypocomplementaemic) glomerulonephritis.


Acidity, osmolality, electrolyte and amino acid concentration of casein-hydrolysate and synthetic amino acid solutions.


Haptoglobulin and   2 -macroglobulin levels in children with rheumatoid arthritis.


The effects of prolonged water exposure on human skin.


Cultural, phagocytic, and bactericidal characteristics of peritoneal macrophages.


The effects of treatment on the local lesion of carcinoma of the prostate.


ATP pools in pure and mixed cultures.

ATP pools in pure and mixed cultures.


Comparison of the chemical and immunological properties of the pili of three types of Corynebacterium renale.


Slime production by Pseudomonas aeruginosa. II. A new synthetic medium and cultural conditions suitable for slime production by Pseudomonas aeruginosa.


Differentiation of mycobacterium tuberculosis from other mycobacteria by susceptibility to ethyl and methyl esters of p-nitrobenzoic acid.


Australian health expenditures.

Australian health expenditures.


Sequential changes in beta-cell function in insulin-treated diabetic patients assessed by C-peptide immunoreactivity.


Susceptibility to meningococcal meningitis.


Function of lipophilic acids as antimicrobial food additives.


Aromatization of androstenedione and testosterone by rhesus monkey hypothalamus and limbic system.


A congenital peripheral ossifying fibroma.


Shock-motivated avoidance and the analysis of behavior.


Nuclear volumes, DNA contents, and radiosensitivity in whole-body-irradiated amphibians.


Treatment for hypertension.

Treatment for hypertension.


Studies on nutritional status and health of Transvaal Bantu and white pre-school children.


Growth standards: an appraisal with special reference to growth in South African Bantu and white pre-school children.


Advances in the application of knowledge of protein calorie malnutrition.


Vitamin C requirements of the vervet monkey (Cercopithecus aethiops) under experimental conditions.


Neonatal pneumatosis intestinalis associated with milk intolerance.


Acquired sensorineural deafness with bony obliteration of the semicircular canals.


Complications of radiotherapy for carcinoma of the uterine cervix.


Acute necrotizing fasciitis in childhood. Report of 11 cases.


Critical points of failure in the therapy of cancer of the cervix: a reappraisal.


Mid-trimester hypertonic saline--induced abortion: effect of indomethacin on induction-abortion time.


The incidence of agenesis and polygenesis in the primate dentition.


Blood groups and haptoglobins in the Eastern Carolines.


Size and shape in similarity coefficients based on metric characters.


A note on the estimation of allele frequencies.


Structural proteins of equine arteritis virus.


Antibodies to type A influenza viruses in sera from nonhuman primates.


The persistence of Aleutian disease virus in the mosquito Aedes fitchii.


Buffalopox virus. (Preliminary report). Brief report.


RNA polymerase in group B arbovirus (dengue-2) infected cells. Brief report.


Treatment of acromegaly.

Treatment of acromegaly.


Studies on psychotropic drugs. XIX. Psychopharmacological studies of 1-methyl-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno(2,3-e)(1,4)diazepin-2-one (Y-6047).


Absorption, distribution, biotransformation, and excretion of azidocillin, a new semi-synthetic penicillin, in mice, rats and dogs.


Structure-activity relationships in the tetrahydrocannabinol series. Modifications on the aromatic ring and it the side-chain.


Purification and characterization of human Factor II.


Sexual behavior of male pigtail macaques in the laboratory.


Regression of the Forbes-Albright syndrome after pituitary apoplexy.


Growth and adaptive hydrogen production of Rhodospirillum rubrum (F 1 ) in anaerobic dark cultures.


Two years' experience with Rh hemolytic disease reporting. California law, since January 1 1970, has required that all pregnant women, regardless of outcome of delivery, be tested for Rho(D) type, that the mother and physician be notified of the result and that hospitals providing service to newborns report all cases of Rho(D) Hemolytic Disease to the State Department of Public Health. Although there has been only a gradual decrease in the number of deaths due to Rho(D) Hemolytic Disease of the Newborn since 1950, there has been a precipitous fall in the past two years. Since the commencement of reporting of the disease to the State Health Department the number of cases has also dropped dramatically. It is felt that because of our conscientiously administered reporting law the morbidity and mortality figures from HDN in California are accurate, in contrast to results obtained in most other states. It is believed that this report reflects the first really accurate look at a large population for the incidence and mortality from Rho(D) HDN since the advent of widespread use of anti-Rho(D) gamma globulin. Review of the recent literature failed to reveal definitive data on recent incidence and mortality trends for Rho(D) HDN. A survey of state health departments also failed to produce data comparable with California's.A number of factors have played a part in reducing the incidence and mortality from Rho(D) HDN in California-namely, required testing of pregnant women combined with the almost routine use of of anti-Rho(D) immune globulin in eligible women, early recognition and treatment of Rho(D) HDN, and the reduction in family size with an increasing percentage of primiparous mothers.


Rleative numbers of pyramidal tract neurons in mammals of different sizes.


Action of hydroxyurea and N-carbamoyloxyurea on the cell cycle of Tetrahymena.


A meiotic mutant defective in distributive disjunction in Drosophila melanogaster. The female meiotic mutant no distributive disjunction (symbol: nod) reduces the probability that a nonexchange chromosome will disjoin from either a nonexchange homolog or a nonhomolog; the mutant does not affect exchange or the disjunction of bivalents that have undergone exchange. Disjunction of nonexchange homologs was examined for all chromosome pairs; nonhomologous disjunction of the X chromosomes from the Y chromosome in XXY females, of compound chromosomes in females bearing attached-third chromosomes with and without a Y chromosome, and of the second chromosomes from the third chromosomes were also examined. The results suggest that the defect in nod is in the distributive pairing process. The frequencies and patterns of disjunction from a trivalent in nod females suggest that the distributive pairing process involves three separate events-pairing, orientation, and disjunction. The mutant nod appears to affect disjunction only.


Differentiation of Drosophila cells lacking ribosomal DNA, in vitro. Drosophila melanogaster embryos that lacked ribosomal DNA were obtained from appropriate crosses. Cells were taken from such embryos before overt differentiation took place and were cultured in vitro. These cells differentiated into neurons and myocytes with the same success as did wild-type controls. Therefore, ribosomal RNA synthesis is not necessary for the differentiation of neurons and myocytes in vitro.


Comparison of acetyl-salicylic acid (aspirin) hydrolase activities in various tissues of several species.


Is the notch locus of Drosophila melanogaster a tandem repeat? Correlation of the genetic map and complementation pattern of selected mutations. Correlation of the complementation relationships between the Notch locus alleles fa(g), fa(no), Ax(59d) and nd, with their genetic map order, suggests a tandem repetition within the locus of functionally related sites. This observation is discussed in relation to two hypotheses: (1) that the Notch locus contains a tandem repeat of genetic material; and (2) that the tertiary structure of the Notch locus product has a spiral configuration.


Physiology and cytological chemistry blue-green algae.


Recombination in Drosophila melanogaster male. T-007 strain of Drosophila melanogaster is known to show recombination in males. The present study established the following points: (1) Clustering occurrence of recombinant, unequal recovery of complementary products of recombination, relatively high frequency of recombination around centromeric region, and relatively frequent occurrence of mosaic phenontype flies-all of these seem to indicate that a considerable fraction of male recombination in the T-007 strain is of premeiotic, or somatic origin, although a fraction still could be of meiotic origin; (2) Male recombination occurs in the third as well as in the second chromosomes, and the frequencies of recombinations are comparable between these two chromosome pairs.


A meiotic mutant affecting recombination in female Drosophila melanogaster. mei-S282 is a female meiotic mutant isolated from a natural population of Drosophila melanogaster. It is a recessive mutation located at approximately map position 5 on the third chromosome which has two major effects. It causes a nonuniform decrease in recombination which is most drastic in distal chromosome regions and nondisjunction of all chromosome pairs is elevated at the first meiotic division. Nondisjunctional events are positively correlated; furthermore, nondisjoining chromosomes, themselves nonrecombinant, are preferentially recovered from cells in which nonhomologs are preferentially recovered from cells in which nonhomologs are also non-recombinant.-It is concluded that mei-S282 is a defect which occurs early in meiosis I prior to the time of exchange. In the mutant, the frequency of no-exchange tetrads for each of the major chromosomes is increased-and in cells which contain two or more no-exchange tetrads, an interaction between these chromosomes leads to correlated nondisjunction. mei-S282(+) then, is an exchange precondition necessary for the normal frequency and distribution of exchanges.


Selection for a threshold character in Drosophilia. IV. Chromosomal analyses of plateaued populations. Chromosome substitution and intra-chromosomal recombination techniques have been employed to determine the genetic basis of limits to selection in lines selected for high scutellar bristle number from the Canberra population. Three observations indicate the presence of an upper threshold affecting some component traits, which is not readily discernible at the level of the selected phenotype:(1) The variance of the number of anterior + interstitial + posterior bristles is progressively reduced as the mean approaches a total of eight at these sites. Total bristle number, which includes apicals in addition to the above three components, and which was the trait subject to selection, shows little evidence of this phenomenon;(2) the effect of a given chromosome substitution is also greatly reduced as the mean approaches eight anterior + interstitial + posterior bristles, by comparison with its effect in genotypes of lower mean;(3) chromosome substitutions show some evidence of negative interaction as this level is approached, in contrast to the positive interactions evident at higher means. All chromosomes except IV are involved in progress beyond the proposed upper threshold. However, chromosome III has the most important effect, due primarily to a major gene located at approximately 61 cM, which also markedly increases dorsocentral and postvertical bristle numbers.


Stroke units in community hospitals: a "how-to" guide.


Medical management of chronic ischemic heart disease.


Cannabinoid effects on liver glycogen stores.


Clindamycin.

Clindamycin.


Radiolabelling of Drosophila embryos.

Radiolabelling of Drosophila embryos.


Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.


Concurrent epidemics of Staphlococcus aureus and group A Streptococcus disease in a newborn nursery. Control with penicillin G and hexachlorophene bathing.


The possible role of the eland (Taurotragus oryx) in the epidemiology of East Coast fever and other bovine theilerioses.


An assessment of methods for measuremennt of glycogen synthetase activity including a new direct one-step assay.


Purification and immunochemical characterization of a human-specific urine and tissue esterase.


Human erythropoietin: studies on purity and partial characterization.


Characterization of the proteins of the small subunits of rat liver ribosomes.


X-ray crystallographic analysis of swine pancreas  -amylase.


Mechanism of raised serum alkaline phosphatase in some liver disorders in the baboon.


Rate of blood-loss estimated by an isotope-dilution method.


Urinary losses of intravenous nutrients.


Effect of carotid ligation on cerebral blood-flow in the baboon.


A chronic experimental model for the production of subarachnoid haemorrhage.


Opportunistic infection.

Opportunistic infection.


Alpha 1  fetoprotein and antialpha 1  fetoprotein in acute viral hepatitis.


CO 2  fixation by the blue-green alga Anacystis nidulans.


Influence of sulfite on growth, slime, and fluorescent pigment formation by Pseudomonas aeruginosa.


Sensitivity to myxin of Escherichia coli treated with ethylenediaminetetraacetic acid.


Nucleotides and nucleotide sugars in early development of Bufo arenarum. I. Mature oocytes.


Impaired assimilation of egg Co 57  vitamin B 12  in patients with hypochlorhydria and achlorhydria and after gastric resection.


Growth and development of the fetal rhesus monkey. IV. Fractional lipid analyses of the developing brain.


Effects of storage and antibiotic treatments on developmental malformations in chickens.


Tryptophan synthetase from Bacillus subtilis. Purification and characterization of the   2  component.


Tryptophan synthetase from Bacillus subtilis. Purification and characterization of the   component.


Enzymatic synthesis of the peptide in bacterial ridine nucleotides. V. Co ++ -dependent reversal of peptide bond formation.


Enzymatic synthesis of the peptide in bacterial uridine nucleotides. VII. Comparative biochemistry.


Biosynthesis of membrane teichoic acid. A role of the D-alanine-activating enzyme.


The proteolytic enzymes of the K-1 strain of Streptomyces griseus obtained from a commercial preparation (Pronase). IV. Structure-function studies of the two smallest serine endopeptidases; stabilization by glycerol during reaction with acetic anhydride.


Assessment of thyrotropin-releasing hormone and thyrotropin reserve in man. Endogenous thyrotropin-releasing hormone (TRH) reserve and pituitary thyrotropin (TSH) reserve were assessed in four normal subjects, three patients post-cryohypophysectomy, one patient with a hypothalamic lesion secondary to trauma, and four patients with Sheehan's syndrome. TSH reserve was determined by the immunoassayable TSH response to 500 mug TRH given i.v. (TRH stimulation test). TRH reserve was assessed by the rebound response in thyroidal iodine release (TIR) following withdrawal of pharmacologic doses of prednisolone (glucocorticoid withdrawal test). When compared with normals, the post-cryohypophysectomy patients demonstrated parallel impairment of TRH stimulation and glucocorticoid withdrawal testing. The patient with the hypothalamic lesion and the four patients with Sheehan's syndrome all had normal TRH stimulation tests, indicating adequate TSH reserve capacity, yet had abnormal glucocorticoid withdrawal tests, indicative of impairment in endogenous TRH reserve or neurohumoral transport. Three of the patients (hypothalamic injury and two Sheehan's) with impaired TRH reserve were euthyroid. THE FOLLOWING CONCLUSIONS WERE REACHED: (a) A combination of the TRH stimulation test and glucocorticoid withdrawal test may allow for differentiation between pituitary and suprahypophyseal disorders. (b) Certain cases of Sheehan's syndrome appear to have impaired endogenous TRH reserve or transport. (c) Euthyroidism can be maintained in spite of diminished TRH reserve.


Indicator dilution measurements of lung volumes and alveolar air exchange during breathing. A new triple tracer indicator dilution technique has been used to measure alveolar ventilation as well as air and tissue volumes in the lungs of experimental animals and man. The tracers indocyanine green, [(121)I]antipyrine and xenon-133 were rapidly injected into the right atrium, while sampling was carried out from a peripheral artery. Blood flow and tissue volumes were obtained by classical analysis of the indocyanine green and antipyrine concentration-time curves. A double exit-port, constant air flow model was used to analyze the xenon curves, because ventilatory loss led to incomplete recovery of the gas tracer in effluent blood. Uniform ventilation and perfusion were assumed. This analysis permitted calculation of alveolar ventilation (VA(Xe)) and functional residual capacity (FRC(Xe)) during normal breathing. In control studies, VA(Xe) was similar to VA(co2), obtained with the steady-state CO(2) method (r = 0.87), while in critically ill patients the xenon measurement was significantly lower, averaging 54% of VA(co2). In theory, underestimates in VA(Xe) and decrease in the ratio VA(Xe)/VA(co2) relate to nonuniformity in regional ventilation and perfusion. The effect is greatest for the slightly soluble gas, xenon. The significant inverse correlation between VA(Xe)/VA(co2) and the physiologic shunt is consistent with this postulate.FRC(Xe) was similar to the predicted FRC in animals but was 76% of the helium measured FRC in patients. FRC(Xe) was significantly lower than the xenon measured air volumes during breath-holding when nonuniformity of ventilation was not operative. Lung tissue volumes in animals were 83% of gravimetric lung weights, while in patients the volumes were much lower than predicted. Nonhomogeneous lung function, including failure to perfuse the entire capillary bed, with resultant incomplete penetration of tracers into all segments of lung air and tissue, may explain these findings. The resultant errors can be significant in sick patients, and may themselves be used to study nonhomogeneities in the distribution of ventilation and volume.


Cerebrospinal fluid and ependymal neurophysin. Neurophysins are "carrier proteins" associated with vasopressin and oxytocin in the neurohypophyseal system. The release of these hormone associated proteins may serve as an indicator of posterior pituitary function. This report describes the measurement of neurophysin in human and monkey plasma and cerebrospinal fluid (CSF) by radioimmunoassay. Tissue neurophysin is also localized in monkey brain by the immunoperoxidase technique. CSF from 68 patients and five monkeys had easily measurable neurophysin in every sample. The concentration of neurophysin in CSF and in plasma of man is 5.4+/-0.30 ng/ml (mean and SEM) and 0.69+/-0.04, respectively. The two means were significantly different (P < 0.001). In paired plasma and CSF specimens which were obtained simultaneously from each of 13 human and five monkey donors, the concentrations of neurophysin in CSF were greater than those of plasma in every case (paired t test, P < 0.001). Neurophysin administered intravenously to dogs did not enter CSF. Using the immunoperoxidase technique, we found neurophysin not only in the supraoptic and paraventricular nuclei, their tracts, and the posterior pituitary, but also in the specialized ependymal tanycytes of the infundibular recess of the third ventricle and in the external layer of the median eminence where capillaries drain into hypophyseal portal vessels. Neurophysin may pass from CSF to portal vessels via tanycytes in a manner similar to that postulated for releasing factors.


Present significance of resistance to trimethoprim and sulphonamides in coliforms, Staphylococcus aureus, and Streptococcus faecalis. The incidence of trimethoprim resistance in coliforms and multiresistant strains of Staphylococcus aureus isolated in Bristol from 1970 to 1972 is low-2.3 and 1.0% respectively. The resistance is probably intrinsic; there is no evidence that it is R-factor or plasmid mediated. A single mechanism that confers resistance to both trimethoprim and sulphamethoxazole has not been detected. Normal growing one-step mutants of S. aureus and Escherichia coli resistant to trimethoprim could not be isolated in vitro. For these reasons cotrimoxazole should retain its usefulness against these bacteria for some years. However, contrimoxazole was found not to be bactericidal against many coliforms. The usefulness of cotrimoxazole against Streptococcus faecalis seems limited because mutants resistant to trimethoprim occurred at high frequency in one step.


Selectagerm: a new approach to clinical bacteriology. A method of processing clinical specimens received at the laboratory on cotton wool swabs is described. The method uses a range of selective culture media to assist in the isolation of potential pathogens from mixed cultures. Because the culture media are distributed in 2 millilitre volumes in the small squares of divided plastic petri dishes it is economically possible to use the same series for every specimen. This facilitates the rapid processing of large numbers of swabs and allows the isolation of pathogens from sites where they might otherwise go unnoticed.


Comparison of the cortical degeneration in the visual regions of the temporal lobe of the monkey following section of the anterior commissure and the splenium.


Vestibular cortical projection in the rabbit.


The projection of nucleus lateralis dorsalis of monkey to basomedial temporal cortex.


Identification of polysomal RNA in BHK cells infected by sindbis virus. Polysomes were prepared from Sindbis virus-infected BHK cells. The major species of RNA in these polysomes was identified as 26S RNA (interjacent RNA) by (i) disrupting the polysomes with EDTA; (ii) treating the infected cells with puromycin; and (iii) isolating polysomes from cells infected with a temperature-sensitive mutant that does not form nucleocapsids. Small amounts of 42S RNA and 33S RNA were also found in polysomes.


Isolation and characterization of a ciliary dyskinetic factor from cystic fibrosis heterozygous serum.


Inhibitory effects of fusarenon-X, a sesqui-terpene mycotoxin, on lipid synthesis and phosphate uptake in Tetrahymena pyriformis.


The role of the university in medical education.


A double-blind crossover trial of disodium cromoglycate powder in perennial allergic rhinitis.


Hay fever in a student population. A trial of disodium cromoglycate.


Low antibiotic resistance of gonococci causing disseminated infection.


Intracellular plutonium: removal by liposome-encapsulated chelating agent. Chelating agents, such as ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA) were successfully encapsulated within lipid spherules (that is, liposomes). Encapsutlated [(14)C]EDTA, given intravenously to mice, was retained longer in tissues that nonencapsulated [(14)C]EDTA. Encapsulated DTPA, given to mice 3 days after pluttonium injection, removed an additional fraction of plutonium in the liver, presumably intracellular, not available to nonencapslulated DTPA. It also further increased urinary excretion of plutonium. Introduction of chelating agents into cells by liposomal encapsulation is a promising new approach to the treatment of metal poisoning


DNA base composition of rickettsiae.

DNA base composition of rickettsiae. There is a small but distinct difference in DNA base composition between the typhus and spotted fever groups of rickettsiae. The molar percentages of guanine plus cytosine for Rickettsia prowazeki, R. typhi, and R. canada are approximately 30, for R. rickettsi, R. conori, and R. akari they are about 32.5. The percentage for trench fever rickettsia, Rochalimaea quintana, is 38.6.


Polychlorobiphenyls in North Atlantic ocean water. Concentrations of polychlorobiphenyls (PCB's) have been measured at the surface and at various depths in the water of the North Atlantic Ocean between 26 degrees N and 63 degrees N. The concentrations average about 20 parts per trillion and amount to an estimated 2 x 10(4) metric tons of PCB's in the upper 200 meters of water. The average concentrations of PCB's in the surface water of the Sargasso Sea are lower than those in the northern North Atlantic.


Evaluation of nutritional management of the low birth weight newborn.


Effect of protein supplementation on the hair of chronically malnourished New Guinean schoolchildren.


Plasma nonessential to essential amino acid ratio in marasmus.


Dietary protein quality in infants and children. IX. Instant sweetened corn-soy-milk blend.


Effect of calorie supplementation on growth of undernourished children.


Further studies on the bactericidal effect of the air-fluidized bed.


Cardiovascular effects of hemorrhage during endotoxemia in unanesthetized monkeys.


Fine structure of photoreceptors in the owl monkey.


Immunoglobulins and improvement in acute schizophrenic reactions.


"Groundsubstance" resembling amyloid extracted from the cervical portion of human cervix uteri.


Various physical parameters which influence photosensitive epilepsy in the Papio papio.


Vocalization in rhesus monkeys: conditionability.


Mirror-image shape discrimination: interocular reversal of responses in the optic chiasm sectioned monkey.


Protein phosphorylation level and in vivo  32 P incorporation in retina and in brain.


Proton magnetic relaxation in solutions of manganese-carbonic anhydrase.


Total parenteral alimentation, with lipid.


Permeability of gastric mucosa to hydrogen and lithium.


Primate biliary physiology. X. Effects of diet and fasting on biliary lipid secretion and relative composition and bile salt metabolism in the rhesus monkey.


Intrahepatic cholestasis due to therapy of rheumatoid arthritis.


Comparison of artificial insemination with natural mating technique in rhesus monkeys, Macaca mulatta.


Induction of embryonic death in sheep by intrauterine injection of a small volume of normal saline.


Ultrastructure and endocrinological correlates of an early implantation site in the rhesus monkey.


Lactoferrin, a major soluble protein of bovine oestrous cervical mucus.


Asthma, pulmonary eosinophilia, and allergic alveolitis.


Genetic control of mitochondrial enzymes in human-mouse somatic cell hybrids.


Rapid generation of whole-body radioautograms with microchannel plate electron image amplifiers.


A review: current status of parenteral amino acid therapy.


Resistance factors and their ecological importance to bacteria and to man.


Boron tris(trifluoroacetate) for removal of protecting groups in peptide chemistry.


Hydronephrosis in infants and children.

Hydronephrosis in infants and children.


Experimental hyperviscosity retinopathy: preliminary report.


Alteration of the ribosomal fraction of Bacillus subtilis during sporulation.


Separation of  35 S-labeled thionucleosides of Escherichia coli and Pseudomonas aeruginosa transfer RNAs on a phosphocellulose column.


Biocontrol of the Florida red tide organism, Gymnodinium breve, through predator organisms.


Council accepts glutaraldehyde (Cidex). Council on Dental Therapeutics.


Direct test for determining sensitivity of M. tuberculosis to streptomycin.


Feline toxoplasmosis and coccidiosis: a survey of domiciled and stray cats.


Rat thyrotrophin levels during heat stress and stimulation by thyrotrophin releasing factor.


Blood parasites of the Norwegian lemming.


Listeria in aquatic animals.

Listeria in aquatic animals.


Hepatozoon procyonis infections in Texas.


A practitioner's view of education for long-term care administrators. 1.


Perinatal asphyxia, causes, detection and neurologic sequelae.


Bilateral oro-ocular cleft. Case report.


A microbiological assay for cyclocytidine--disposition studies in mice.


Carcinoembryonic antigen (CEA): radioimmunoassay using highly purified CEA and  125 I CEA.


On the significance of the anti-muscle and erythrocyte membrane factors in systemic lupus erythematosus.


Histaminase level changes in liver damage.


Utilization of the platelet release reaction to measure ITP factor and platelet antibodies.


Surface immunoglobulins on circulating lymphocytes in mouse and human plasmacytoma.


Glucuronide synthesis in the rat and guinea pig lung.


Isolation and properties of proteolytic enzymes of streptomyces erythreus. II. Properties of crude enzyme preparation.


Antibiotic properties of Bacillus subtilis strain No. 53 isolated from the intestinal flora of Galleria mellonella L. larvae.


Supporting elements in the organ of Corti. I. Fibrillar structures in the supporting cells of the organ of Corti of mammals.


Stria vascularis.

Stria vascularis.


Macula utriculi and macula sacculi in the squirrel monkey.


IgG myeloma and Waldenström macroglobulinemia. Coexistence and clinical manifestations in one patient.


A membrane oxygenator for ex vivo perfusion of small organs.


Comparison of Hepa-Gent and hepatitis associated antigen as determinants of liver disease.


Diabetic coma: serum growth hormone before and during treatment.


The inhibition by denervation of the effect of testosterone on glycogen metabolism in the levator ani muscle.


Effect of 2-deoxy-D-glucose on insulin response to glucose in intact and adrenalectomized monkeys.


Positive and negative feedback control by estrogen of luteinizing hormone secretion in the rhesus monkey.


Effect of human menopausal gonadotropin upon spermatogenesis and testosterone production in juvenile rhesus monkeys.


Thyrotropin releasing hormone interactions with an anterior pituitary membrane receptor.


Cyanide binding to carbonic anhydrase. A  13 C-nuclear-magnetic-resonance study.


The subunit structure of the aliphatic amidase from Pseudomonas aeruginosa.


A new medium for the isolation of pathogenic Neisseria (NYC medium). I. Formulation and comparisons with standard media.


A new medium for the isolation of pathogenic Neisseria (NYC medium). II. Effect of amphotericin B and trimethoprim lactate on selectivity.


A new medium for the isolation of pathogenic Neisseria (NYC nmedium). 3. Performance as a culture and transport medium without addition of ambient carbon dioxide.


Histochemical identification of non-culturable mycobacteria (M. leprae and M. lepramurium). II. Dopa-oxidase.


Elimination pattern of Aroclor 1254 components in the bobwhite.


Preparative isolation of phosphonolipids by ascending dry-column chromatography.


Validation of a "clearing" assay for milk lipoprotein lipase in agarose gel. We have developed a simplified method for the quantitative assay of lipoprotein lipase in cow's milk based on the hydrolysis of a glyceride emulsion in semisolid agarose gel. The area of clearing produced thereby is a function of enzyme concentration. Absolute molar rates for unknown samples may be calculated if standards of known activity are used concurrently. The precision of the simplified assay compared favorably with a method based on titrimetric determination of the rate of free fatty acid release. A modified assay has been used to assess the potency of lipoproteins in lipoprotein lipase activation.


Mechanism of the mitogenic action of the Phytohemagglutinin. I. Induction of tolerance and lymphocyte transformation.


Preparative electrophoretic separation of normal and neoplastic human bone marrow cells.


Unique properties of nucleic acid from Bacillus subtilis phage SP-15.


Structure of a new pyrimidine from Bacillus subtilis phage SP-15 nucleic acid.


On the organization of higher chromosomes.


Differential under-replication of satellite DNAs during Drosophila development.


Waldenström's macroglobulinemia, mesangio-capillary glomerulonephritis, angiitis and myositis.


Activity of 15[S] 15-methyl prostaglandin E2 and F2alpha as stimulants of uterine contractility.


Histochemical localization of acetylcholinesterase enzyme in the "limbic system" of the brain of the cebus monkey (Cebus apella).


Respiratory diseases.

Respiratory diseases.


Cerebral angiography in focal epilepsy.

Cerebral angiography in focal epilepsy.


Ossification of the posterior longitudinal ligament--a roentgenologic and clinical investigation.


Letter to the editor: latex agglutination and gel diffusion precipitin test in the diagnosis of amebic liver abscess.


Neurophysiologic aspects: extrahypothalamic factors in the regulation of food intake.


Thermophilic mutants of Pseudomonas fluorescens.


Extensive immunochemical cross-reactivity between mammalian serum proteins.


Antimicrobial activity os some 7-nitro-and 7-amino-dialkylaminomethyl-8-hydroxyquinolines.


The frequency of M-components in sera of patients with solid malignant neoplasms. The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case of Waldenström's macroglobulinaemia, none of the patients were found to be suffering from these diseases. The frequency of M-components increased with age, and this was more evident in males. Twenty-two of 60 patients with M-components did not exhibit abnormalities on immunoelectrophoresis. Of the 35 remaining patients, 27 had an abnormal component of the IgG class, 6 of the IgA and 2 of the IgM class. M-components were found in the sera of patients with a wide variety of neoplasms. There appeared to be no evidence of an increased frequency of M-components in the sera of patients with solid malignant neoplasms compared with normal adult population.


The protective role of proteins from Salmonella typhimurium in infection of mice with their natural pathogen.


Influence of psychological variables on stress-induced pathology.


IgA deficiency in children. Immunoglobulin-containing cells in the intestinal mucosa, immunoglobulins in secretions and serum IgA levels.


Uptake of antilymphocyte globulin by human peripheral lymphocytes.


Autoantibodies in children with coeliac disease.


Identification of Neisseria gonorrhoea and Neisseria meningitidis by a carbohydrate disc technique.


The oxidase activity of chromobacterium.


A screening test for IgG deficiency.

A screening test for IgG deficiency.


Neurofibromatosis with sarcoma. Sarcoma complicating von Recklinghausen's neurofibromatosis.


Critical issues in the assessment of quality of care and their relationship to HMOs.


A developmental experience in prepaid group practice.


Normalized resin uptake of displaced  125 I-T 4  using denatured serum.


The use of a probe-type colorimeter for the continuous monitoring of pH in association with the  137m Ba-EDTA infusion system.


Combined carbenicillin and gentamicin therapy of pseudomonas septic arthritis.


The use of clonazepam as an anticonvulsant--clinical evaluation.


Cell membranes: structure and function.

Cell membranes: structure and function.


Is polio a model for consumer research?

Is polio a model for consumer research?


Circulating sensitized lymphocytes in systemic lupus erythematosus.


Recent developments in the chemotherapy of schistosomiasis.


Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis. I.


Relationship between endotoxin-induced abortion and the synthesis of prostaglandin F.


Hyperosmolar hyperglycemic nonketotic coma complicating intravenous hyperalimentation.


Immunologic events preceding clinical exacerbation of systemic lupus erythematosus.


Phosphoglycerate kinas polymorphism in Drosophila.


Improved procedure for the isolation of J-chain from human polymeric immunoglobulins.


Isolation and properties of protein fractions from navy beans (Phaseolus vulgaris) which inhibit growth of rats.


Conformation and immunochemistry of parvalbumin 3 from pike white muscle. Modification of the arginine residue with 1,2-cyclohexanedione.


Water and ions in muscles and model systems. THE NUCLEAR MAGNETIC REASONANCE (NMR) RELAXATION TIMES OF PROTONS IN TOAD MUSCLE WATER HAVE BEEN MEASURED AT THREE FREQUENCIES: 2.3, 8.9, and 30 MHz. The results are analyzed in terms of a distribution of correlation times, and it is found that only a few percent of the observed protons have mobilities more than two orders of magnitude smaller than normal. Sodium and chloride ion chemical potentials in some hydrated materials with similar proton NMR characteristics to toad muscle have been found to be heightened, but not sufficiently to account for the distribution of sodium ions in muscle.


Myocardial performance in hemorrhagic shock in the dog and primate.


Thyroid antibodies and protein-binding of thyroxine in patients with and without thyrotoxicosis.


Halting the progress of Zenker's diverticula.


Efficacy of Haffkine Institute polyvalent antivenin against Indian snake venoms.


On the etiology of choleraic diarrhoea.

On the etiology of choleraic diarrhoea.


Electrophoretic patterns of Brucella positive human and bovine sera.


Gel precipitation test for detection of plague infection.


Vital signs in progressive intracranial hypertension: an experimental study.


Effect of hydrocortisone on immunoglobulin synthesis and secretion by human peripheral lymphocytes in vitro.


Wart-associated antigens. I. Isolation of tissue antigens using antibody immunoadsorbents.


Size of DNA determined by viscoelastic measurements: results on bacteriophages, Bacillus subtilis and Escherichia coli.


Characterization of the Bacillus subtilis W23 genome by sedimentation.


Transplantation and cytogenetic studies of Herpesvirus saimiri-induced disease in Marmoset monkeys.


Tumor chemotherapy: efficacy dependent on mode of growth.


Salt adaptation in Bufo bufo.

Salt adaptation in Bufo bufo. 1. The capacity of adaptation of toads (Bufo bufo) to environments of high salinity was studied and the relative importance of skin, kidney and urinary bladder in controlling the balance of water and salt was assessed.2. Toads were kept in NaCl solutions of 20, 50, 110, 150 and 220 mM and studied in their fourth week of adaptation. A group of animals considered as ;control' was kept in wet soil with free access to water. Plasma, ureter urine, and bladder and colon contents were analysed for sodium, potassium, chloride and osmolality, and total body sodium and water were determined. Absorption of water and (22)Na through the skin, and water flow and sodium excretion through the ureter, of intact animals was studied. Hydrosmotic water transport through the isolated urinary bladder of ;control' and adapted animals was determined. The effects of pitressin and aldosterone on the water and sodium balance are described.3. The survival rates of toads kept in saline concentrations up to 150 mM were identical to that of ;control' animals, but half of the animals kept in 220 mM died within 4 weeks.4. There is a linear correlation between the sodium concentrations and osmolality of plasma and of the external media.5. The sodium concentration in colon contents rose with rising external concentrations, up to values higher than the values in plasma.6. Sodium concentrations and osmolalities of ureter and bladder urine increased in adapted animals, the values for bladder urine becoming much higher than those for ureter urine in animals adapted to 110, 150 and 220 mM.7. Total body water, as a percentage of total weight was kept within very narrow limits, although the total body sodium increased with adaptation.8. Absorption of water through the skin for the same osmotic gradients was smaller in adapted than in ;control' animals.9. The ureteral output of water of toads adapted to 110 and 150 mM-NaCl was larger than the water absorption through the skin.10. Skin absorption of sodium was lower in animals adapted to concentrated saline solutions than in ;control' animals.11. Sodium output by the ureter was identical to skin absorption in ;control' animals adapted to 20, 50 and 110 mM-NaCl but was higher in animals adapted to 150 mM-NaCl.12. Aldosterone increased the absorption of sodium in ;control' and adapted toads, but at all dose levels absorption by control was greater than by adapted animals.13. The stimulation of water absorption by vasopressin in vivo or in isolated bladders was not modified in animals adapted to high salinities.


Effect of caffeic and p-coumaric acids on indole-3-acetic acid catabolism.


Candida serology: an aid in diagnosis of deep-organ candidiasis.


The effect of a preceding stimulus on temporal facilitation at corticomotoneuronal synapses. 1. Intracellular recordings were made of minimal corticomotoneuronal e.p.s.p.s in lumbar motoneurones of anaesthetized monkeys. For intervals of 2 msec and greater between paired cortical shocks, the average time course of facilitation of the second e.p.s.p. with respect to the first could be fitted closely by a negative exponential with a time constant of 10 msec.2. In the same motoneurones, ;triplets' of corticomotoneuronal e.p.s.p.s were generated by delivering three identical stimuli to the motor cortex. Considering the triplet as a conditioning e.p.s.p. followed by a test pair, the facilitation of the third e.p.s.p. with respect to the second was measured for various combinations of test and conditioning intervals. In each case the amplitude of the third e.p.s.p. was also compared with that of the first (conditioning) e.p.s.p.3. The effect of a brief conditioning interval was to reduce considerably the facilitation of the third e.p.s.p. with respect to the second at all test intervals from 2 to 50 msec. Combinations of brief conditioning intervals (e.g. 2 or 5 msec) and long test intervals (e.g. 20 or 50 msec) caused the third e.p.s.p. to be smaller than the second. As the conditioning interval lengthened, facilitation in the test pair increased towards the unconditioned values at all test intervals.4. Facilitation of the third e.p.s.p. with respect to the first could be described approximately as the linear addition of two facilitation components, one due to the conditioning input and one due to the first stimulus of the test pair. Each component followed the same negative exponential time course as found for an isolated pair of e.p.s.p.s and each of the first two inputs contributed to the facilitation of the third e.p.s.p. as if the other of these two inputs had not occurred.


The high cost of gunshot and stab wounds.


The inverse relationship between cost and survival.


Asthma in childhood.

Asthma in childhood.


Oxidation of carcinogenic azo-dyes 13. Metabolites of some 3'-substituted derivatives of dimethylaminoazobenzene in the bile of rats.


Riboflavin deficiency in Tetrahymena priformis.


Preparation of ova for scanning electron microscopy.


The effect of dexamethasone on the edema of focal cerebral ischemia.


A study of regional autoregulation in the cerebral circulation to increased perfusion pressure in normocapnia and hypercapnia.


Training and preparation of teachers for schools of medicine and of allied health sciences: report of a WHO study group.


Alkaline ribonuclease inhibitor in rat thyroid.


Effects of estrogen and progesterone on acute activation of uterine phosphorylase.


Preparation and standardization of formol toxoid from the venom of Trimeresurus flavoviridis (Habu).


An attempt to classify by serological techniques the toxic proteins of low molecular weight extracted from Elapidae and Hydrophiidae venoms.


Changing antigenic character of venom.

Changing antigenic character of venom.


The inotropic effect on the heart of stimulating the vagus in the dog, duck and toad. 1. The chronotropic and inotropic effects of stimulating the vagus on the hearts of the dog, duck and toad were studied.2. The maximum rate of rise of pressure in the left ventricle (dP/dt max) measured at a constant heart rate and mean aortic pressure was used as an index of the inotropic changes.3. The sensitivity of dP/dt max as an index of inotropic changes brought about by stimulating the vagus was established in the toad where a 49% reduction in heart rate was associated with a 30% reduction in dP/dt max.4. In the dog stimulation of the vagus resulted in a reduction in heart rate of 38% and only a small reduction in dP/dt max of 6%.5. Results similar to those found in the dog were obtained in the duck where the reduction in heart rate of 44% was associated with reduction in dP/dt max of only 3%.6. It is concluded that the vagus has only a small and negligible negative inotropic effect on the ventricles of the dog and duck.


Middle ear effusions. Quantitative analysis of immunoglobulins.


Effects of prostaglandins E 1 , E 2 , A 1  and A 2  on resistance and capacitance vessels in the hind limb of the dog.


Determination of polychlorinated biphenyls in carbonless copying papers by the oxygen flask combustion method.


Circadian and interpersonal variability of IgA in nasal secretions.


Agarose precipitation pattern with dextran-sulfate in viral hepatitis.


Diploid cell lines from subhuman primates as substrates for virus vaccine production.


Detection of viruses in non-human primate tissues by use of explants.


Comparative study of techniques using complement activation for Australia antigen detection.


An Australia-antigen antibody of equine origin.


Optimising reagents for AU-SH-HA antigen screening.


Immune response to plain and adsorbed cholera vaccines.


The detection of intestinal IgA in children following oral typhoid vaccine.


Standardization of AU-SH-HA antigen and AU-SH-HA antibody in crossover-electrophoresis.


The epidemiology of Pseudomonas aeruginosa and the development of a polyvalent vaccine.


Preparation and assay of horse anti-Pseudomonas serum and  -globulin in mice.


Active immunization of burned patients with a new multivalent Staphylococcus-Pseudomonas vaccine.


Clinical use of monovalent vaccines in the treatment of Pseudomonas aeruginosa infection.


Studies on the biological activity of tuberculin active peptides.


Biological activity of a surface component of Neisseria meningitidis.


The immunological responses observed in field studies in Africa with group A meningococcal vaccines.


Trial of a serogroup A meningococcus polysaccharide vaccine in Nigeria.


Australia antigen and post transfusion hepatitis.


Application of paper discs in immuno-electro-osmophoresis for detection of HAA (hepatitis associated antigen).


Infectious patterns of Australia antigenemia and antibodies in chimpanzees.


Incidence and patterns of antibody to hepatitis-associated (Australia) antigen.


Imaging of bone metastases with  99m Tc-Sn-EHDP (diphosphonate),  18 F, and skeletal radiography. A comparison of sensitivity.


Individualized compensating filters and dose optimization in pelvic irradiation.


Increased rate of complications as a result of treating only one prescribed field daily.


Time-dose and tumor volume relationships in the irradiation of squamous cell carcinoma of the tonsillar fossa.


Female urethral carcinoma.

Female urethral carcinoma.


The prognostic significance of radiation-related eosinophilia. A preliminary report.


A high-energy x-ray beam generation program for a small digital computer.


Erythroleukaemia in a melphalan-treated patient with primary macroglobulinaemia.


Regulation of valine degradation in Pseudomonas fluorescens UK-1. Induction of enoyl coenzyme A hydratase.


Regulation of valine degradation in Pseudomonas fluorescens UK-1. Induction of methylmalonate semialdehyde dehydrogenase.


Rapid determination of antimicrobial susceptibility for urgent clinical situations.


Clinical laboratory study of cephacetrile and cephalothin against bacteria recently isolated from clinical specimens.


Synthesis of glycogen in the psoriatic lesion.


Neurofibromatosis associated with malignant neurofibromas.


Angiokeratoma corporis diffusum with alpha-L-fucosidase deficiency.


Intertriginous xanthomata in type 2 hyperbetalipoproteinemia.


Species distribution of testosterone-binding globulin.


Immunologic studies of the rabbit coagulating gland and its secretions.


The clinical significance of spike and wave abnormalities in the adult.


Effects of illness (Phlebotomus fever) on sustained performance and muscular output.


Clinical renal transplantation.

Clinical renal transplantation.


Location of histidine residues that react with bromoacetazolamide and N-bromoacetylacetazolamide in human and bovine carbonic anhydrases.


Characterization of a fatty acid synthetase from Corynebacterium diphtheriae.


Enzymatic conjugation of epoxides with glutathione.


Pattern of recovery following cerebellar deep nuclear lesions in monkeys.


Reversible conversion of lysine monooxygenase to an oxidase by modification of sulfhydryl groups.


Adipose tissue glycogen synthetase. I. Kinetic properties.


Rapid maneuvers to determine location of endotracheal tube in newborn infants.


Behavioral effects of autocerebral perfusion, hypothermia and arrest of cerebral blood flow in the rhesus monkey.


Behavioral effects of sequential and one-stage ablations of orbital prefrontal cortex in the monkey.


Supplemental intravenous alimentation in low-birth-weight infants.


Intravenous supplementation of L-amino acids and dextrose in low-birth-weight infants.


Nasojejunal feeding: an improved device and intubation technique.


Nasojejunal alimentation for premature and full-term newborn infants.


Effect of Newcastle disease virus on human or rabbit platelets. Aggregation and loss of constituents.


Bulk elastic properties of excised lungs and the effect of a transpulmonary pressure gradient.


Transpulmonary pressure gradient and ventilation distribution in excised lungs.


A note on mucus shear rates.

A note on mucus shear rates.


Tetracycline effect on calcification of the molars of rat offspring.


Evaluation of arm circumference measurement for determining nutritional status of children and its use in an acute epidemic of malnutrition: Owerri, Nigeria, following the Nigerian Civil War.


The function of the illusions of control and freedom.


Serum and red cell folates, and serum vitamin B 12  in protein calorie malnutrition.


Oxidative phosphorylation in Azotobacter vinelandii. Energy-linked pH changes and fluorescence changes of atebrin and 1-anilinonaphthalene-8-sulphonate.


Algal nitrogenase, reductant pools and photosystem I activity.


Light-induced slow changes in chlorophyll a fluorescence in isolated chloroplasts: effects of magnesium and phenazine methosulfate.


Contamination of E.C.G. electrode pads with Klebsiella and Pseudomonas species.


Immunodiffusion assay of poricin (NSC-107455).


Phase I clinical trial of a new antitumor agent, 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene- -D-glucopyranoside) (NSC-141540; VP-16-213).


Nonketotic hyperglycemia due to prednisone (NSC-10023) following ketotic hyperglycemia due to L-asparaginase (NSC-109229) plus prednisone.


Symposium on in vitro studies related to atherogenesis. Life histories of hyperplastoid cell lines from aorta and skin.


Genesis and possible dissolution of neuronal lipofuscin.


Metaphyseal dysostosis, Jansen type.

Metaphyseal dysostosis, Jansen type.


Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A. The procoagulant material of lymphocytes has been characterized as tissue factor. Lymphocytes stimulated with phytohemagglutinin or the purified protein derivative of the tubercle bacillus developed procoagulant activity with incubation in tissue culture. While this material corrected the prolonged clotting time of factor VIII (AHF) deficient plasma, we have shown, utilizing a sensitive radioimmunoassay, that no AHF antigen was present in the cell cultures. Further, we have demonstrated this material to be tissue factor by coagulation techniques and immunological cross-reactivity. The published data regarding factor VIII synthesis is reviewed in light of these observations and comments are made regarding the role of the lymphocyte procoagulant.


[Oestrogen synthesis from (4- 14 C-1,2- 3 H)testosterone by a 160 000 g supernatant from baboon placenta and by postmicrosomal fractions].


Oral penicillins.

Oral penicillins.


The fine structure of melanogenesis in coat color mutants of the mouse.


A bone morphogenetic system in residues of bone matrix in the mouse.


Environmental interaction and memory during Petit Mal (absence) seizures.


Residues of organochlorine pesticides, polychlorinated biphenyls, and mercury and autopsy data for bald eagles, 1969 and 1970.


DDT, DDE and polychlorinated biphenyls in biota from the Gulf of Mexico and Caribbean Sea--1971.


Griseofulvin: immunosuppressive action.

Griseofulvin: immunosuppressive action.


Ontogeny of IgA in normal and neonatally bursectomized chickens, with corroborative data on IgY and IgM.


Immunoelectroosmophoresis-immunodiffusion in paracoccidioidomycosis.


Coccidioidomycosis naturally acquired by a monkey, Cercocebus atys, in Davis, California.


The effect of saline solution resuscitation on pulmonary sodium and water distribution.


Canine hemolytic complement: optimal conditions for its titration.


Cytopathic effects of Leptospira serotypes patoc and canicola in three kidney cell culture systems.


Survival of bluecomb agent in embryonating turkey eggs and cell cultures.


Lymphoma induction and viral isolation from owl monkey (Aotus trivirgatus) inoculated with lymphoma cells induced by Herpesvirus saimiri.


Ossification in the jugular foramen in an ancient skull.


Viral isolates from livestock in northern Nigeria: 1966-1970.


Preparation of myosin rods from myofibrils.


Myosin chains of myocardial tissue. I. Purification and immunological properties of myosin heavy chains.


A method for extracting intact chloroplast and cytoplasmic ribosomal RNA from leaves.


Acute spinal cord injury in primates produced by an inflatable extradural cuff.


Suction excision biopsy for diffuse pulmonary disease.


Intercomparison of results obtained with five commercial diffusion plates supplied for quantitation of immunoglobulins.


Pulmonary hemorrhage syndrome as a manifestation of disseminated intravascular coagulation: analysis of ten cases.


Listeric abortion studies in sheep. II. Feto-placental changes.


Listeric abortion studies in sheep. 3. Feto-placental-myometrial interaction.


Listeric abortion studies in sheep. IV. Histopathologic comparison of natural and experimental infection.


Tyrosinase in the presumptive pigment cells of ascidian embryos: tyrosine accessibility may initiate melanin synthesis.


Radioimmunoassay of ovine FSH.

Radioimmunoassay of ovine FSH.


Thromboembolic sequelae to indwelling silastic cannulas in sheep arteries.


Brief communication: melanoma-specific antibodies produced in monkeys by immunization with human melanoma cell lines.


Thermal enhancement of thio-TEPA cytotoxicity.


N-oxidation of certain aromatic amines, acetamides, and nitro compounds by monkeys and dogs.


The release and molecular state of mammalian brain acetylcholinesterase.


The effects of tetraphenylboron on the isolation of neuronal and glial cells from guinea-pig brain.


Proteinuria in pre-eclampsia.

Proteinuria in pre-eclampsia.


Depolarization increases the susceptibility of toad bladder sodium transport to inhibition by ouabain.


Dependence liability of several sedative-hypnotic agents evaluated in monkeys.


Gonorrhea detection by urine sediment culture.


Morphogenesis and structure of a virus in cells cultured from brain tissue from two cases of multiple sclerosis.


Impaired performance on delayed matching in monkeys by heptabarbitone, pentobarbitone sodium and quinalbarbitone sodium.


The effect of low-energy electron bombardment on bacterial spore catalase.


Intrahemocoelic infection of ticks Ornithodoros moubata (Murray) due to Rickettsia prowazeki and the influence of some antibiotics on growth curve of this bacteria.


The effect of some antibiotics on Rickettsia prowazeki and Yersinia pseudotuberculosis in body louse Pediculus humanus humanus L.


The acute inhalation toxicology of chlorine pentafluoride.


Contraceptive effect of intrauterine application of Lugol's solution. The contraceptive effect of local application of Lugol's solution (5% elemental iodine and 10% potassium iodide in aqueous solution) to the uterine cavity was evaluated in rats, 1 monkey and humans.  18 experimental rats received .1 ml Lugol's solution injected into the left uterine horn to cover the entire cavity; 2 received .05 ml solution covering two-thirds of the left uterine horn; 12 control rats received saline in the left horn;  right uterine horns were left intact.  Control rats had 76 pregnancies in the left horn and 70 in the right; the 18 rats treated with .1 ml solution had no pregnancies in the left horn and 121 in the right; 2 rats receiving .05 ml solution had 2 and 3 pregnancies, respectively, in  the left horn.  Lugol's solution prevented nidation in rats, and its action was local rather than systemic.  Lugol's solution applied transvaginally to the uterine cavity of 1 Macaca mulatta adult virgin female monkey after confirmed existence of a developed Graffian follicle was followed by artificial insemination in the treated cycle and 2 cycles  later.  Ovulation and menstruation occurred during the treated and subsequent cycles, but conception occurred in the third cycle.  Effect of Lugol's solution appears temporary.  Preliminary clinical observation in a limited number of human volunteers in the U.S., Japan and Mexico who had Lugol's solution applied to the uterine cavity using a cotton-tip applicator indicates that application on Days 16 and 17 of the  cycle resulted in no contraceptive effect, but on Day 20-24, resulted in no pregnancies through contraceptive or abortive effect.  No irregular and/or abnormal bleeding occurred.  A long-term observation and evaluation of the study is warranted to determine side effects of monthly solution application, such as endometrial changes and irregular bleeding.  This procedure may be useful in cases of rape because of the endometrial effect and direct spermicidal effect of Lugol's solution if applied soon after coitus.  A discussion of study limitations is presented, and the need for development of a simple, harmless and inexpensive contraceptive method which can be practiced by paramedical personnel as well as physicians is stressed.


Neurofibromatosis and renovascular hypertension in children.


Sjögren-Larsson syndrome with epiphyseal-metaphyseal dysplasia.


Protein sparing therapy during periods of starvation with sepsis of trauma.


Prevention of pseudomonas respiratory infection in a surgical intensive care unit.


Transformability of DNA polymerase-deficient mutants of Bacillus subtilis.


Unusual frequency of Negro admixture in necropsies of Chagas disease cases in Bahia, Brazil.


Further evidence that TRH is also a physiological regulator of PRL secretion in man.


Substitution of lysine for threonine at position 100 in human carbonic anhydrase Id Michigan.


Identification of globin mRNA in 10s RNA of rabbit reticulocytes.


Fructose infusion hazards.

Fructose infusion hazards.


Phenesterin (NSC-104469)--clinical brochure.


Procedures for preclinical toxicologic evaluation of cancer chemotherapeutic agents: protocols of the laboratory of toxicology.


Preclinical toxicologic studies of  -thioguanine deoxyriboside (NSC-71261).


Preclinical toxicologic study of actinomycin D (NSC-3053).


Single-dose toxicity of cyclophosphamide (NSC-26271) in dogs and monkeys.


Preclinical toxicologic study of procarbazine (NSC-77213).


The current status of serologic, immunologic and skin tests in the diagnosis of pulmonary mycoses. Report of the Committee on Fungus Diseases and Subcommittee on Criteria for Clinical Diagnosis--American College of Chest Physicians.


Enucleation and primary closure of jaw cysts.


A 5-year follow-up study of retention of prong dentures by skin-folded pockets.


Newer concepts of odontogenic cysts.

Newer concepts of odontogenic cysts.


Periodontal status after fixation with Sauer's and Schuchardt's arch bars in jaw fractures.


Two cases of aneurysmal bone cysts of the jaws.


Unusual fracture dislocation of the mandibular condyle in a 6-year-old child.


Partial ureteral obstruction in the monkey. A comparison of hydrated versus dehydrated scintophoto studies for evaluation.


Direct measurement of sodium uptake by toad bladder mucosal cells.


Effects of administering antisera to mouse growth hormone and prolactin on gain in litter weight and on mammary nucleic acid content of lactating C3H mice.


Primary drug resistance of mycobacteria tuberculosis in Taiwan.


Studies on immunodiagnosis of angiostrongyliasis. 1. Detection of antigen and antibody in serum and cerebrospinal fluid.


Immunobiological activity of radiolabeled antihormone antibodies.


Reactions to intrinsic and extrinsic rewards in protein-malnourished monkeys.


Inferotemporal evoked potentials after visual discrimination training in squirrel monkey.


Cell-mediated immunity and resistance to infection: report of a WHO scientific group.


The effects of total-body x-irradiation on Trypanosoma cruzi infection (Chagas' disease) in mice and rats.


Influence of the type of fabric on the dissemination of bacteria from textiles.


Some aspects of the histology of the nonhuman primate nasopharynx.


The external glial limiting membrane in Macaca: ultrastructure of a laminated glioepithelium.


Colorimetric and fluorometric carbohydrate determination with p-hydroxybenzoic acid hydrazide.


Control of synthesis and distribution of acyl moieties in etiolated Euglena gracilis.


Increased dosage of disodium cromoglycate.


Meningococcal pericarditis without meningitis.


Prolonged action of pindolol.

Prolonged action of pindolol.


Hepatitis B antigen inhibitor in human faeces and intestinal mucosa. Hepatitis B antigen (HB Ag) positive sera became negative after in-vivo incubation with homogenates of human faeces or intestinal mucosa. This was found to occur in all sera tested by various methods. These findings suggest the existence in the human intestine of a substance able to inactivate the HB Ag and that it is not an antibody or of the nature of interferon. The presence of an inhibitor could explain why B-type hepatitis is seldom if ever faecally transmitted and also the low oral infectiousness of the B virus.


Australian antigen in reference sera.

Australian antigen in reference sera.


Intestinal goblet cell mucus: isolation and identification by immunofluorescence of a goblet cell glycoprotein.


Production of staphylococcal enterotoxin A in Blue, Brick, Mozzarella, and Swiss cheeses.


Effect of thyrotropin releasing hormone on yield and composition of bovine milk.


The role of Z substance in sarcomerogenesis.


Effect of rhesus haemolytic disease upon birthweight.


Bacterial prostatitis vs "prostatosis". A clinical and bacteriological study.


Infection control in parenteral nutrition.


Therapeutic success in Paget disease.

Therapeutic success in Paget disease.


Detection of neoantigens in the serum of patients with active neoplastic diseases by the absorption-immunodiffusion method.


Development of methyltransferase activities of human fetal tissues.


Observations on the thyroid gland in rats following the administration of sulfamethoxazole and trimethoprim.


Biological responses of the rat to polychlorinated biphenyls.


Infiltrative, ulcerative, and fistular lesions of the penis due to lymphogranuloma venereum.


Sensitivity to penicillin of Neisseria gonorrhoeae in Bangkok. Relation to the results of treatment.


Respiratory disease in industry due to B. subtilis enzyme preparations. Detergent industry workers are known to become sensitized to enzyme preparations added to the products. In a Canadian plant about 25% of 644 employees exposed to airborne commercial B. subtilis enzyme preparations became sensitized. Skin tests with a number of antigens, including purified enzyme preparations, illustrated differences from person to person in the components to which there was sensitization. The presence of respiratory symptoms related to the industrial exposure was reported much more commonly among sensitized workers. Among employees obliged to miss work, FEV(1) values after 24 months were considerably higher than those obtained during the time of initial difficulties. Blood eosinophilia was observed in sensitized workers. Serum IgG antibodies to the enzyme preparations were demonstrable in most sensitized individuals but did not provide a reliable index of sensitization or of the symptomatic state.


Computer record linkage on a survey population.


The extent of specific adsorption of cytotoxic educated thymus cells: evolution with time and number of injected cells.


Bacteriological and clinical observations of experimental infection with Pseudomonas aeruginosa in mice.


Cross protective immunity in mice injected with heat-killed cells of Pseudomonas aeruginosa and Serratia marcescens.


Psychopathological perspectives.

Psychopathological perspectives.


Analysis of stomatogenesis by scanning electron microscopy in Tetrahymena pyriformis strain W during synchronous cell division.


Energy and protein requirements: report of a joint FAO-WHO ad hoc expert committee. Rome, 22 March - 2 April 1971.


Alpha-fetoprotein and carcinoembryonic antigen in a case of gastric carcinoma metastatic to the liver.


A cytotoxic effect on monkey kidney cells induced by sera from patients with acute renal failure and suggesting endotoxinaemia.


Life threatening infections in cancer patients.


Diet and colon cancer.

Diet and colon cancer.


[Morphological studies of unknown filarial larvae from Simulium damnosum, the vector of onchocerciasis, and from S. kenyae in Liberia with reference to their possible final hosts].


Survey of paranasal sinuses X-ray. Ethnological clinical analysis of 1,000 Chinese, Indians, Malays, and "others".


The indirect haemagglutination and charcoal-agglutination tests in the diagnosis of African sleeping sickness.


Gas phase separation following decompression in asymptomatic rats: visual and ultrasound monitoring.


Production of gaseous nitrogen during human steady state exercise.


Idiopathic central serous retinopathy (choroidopathy) in flying personnel.


Psychiatric and psychometric predictability of test pilot school performance.


Decompression sickness in USAF operational flying, 1968-1971.


Effects of lidocaine and propranolol on the normal and anomalous pathways in patients with preexcitation.


Effect of isoproterenol on the abnormal T wave.


Regression of extreme pulmonary hypertension after mitral valve surgery.


Surgical treatment of unilateral renal vascular disease. Prognostic role of vascular changes in bilateral renal biopsies.


Protection against epinephrine-induced myocardial necrosis by drugs that inhibit platelet aggregation.


Spread of excitation from the atrium into thoracic veins in human beings and dogs.


Quantitative radionuclide angiocardiography for determination of chamber to chamber cardiac transit times.


Changes of atrioventricular conduction with age in infants and children.


Late onset complete heart block. Newly recognized sequela of cardiac surgery.


Morphologic features of right ventricular ectopic beats.


Intermittent left anterior hemiblock with Wenckebach phenomenon.


Corrected transposition of the great arteries masquerading as coronary artery disease.


Some controversy regarding the peripheral distribution of the conduction system.


Complications of Beall valve prosthesis.


Inferior wall myocardial infarction and atrioventricular nodal disease.