Cytotoxic potential of mouse spleen cells on H-2 antibody-treated target cells.


Metabolic and functonal studies on activated mouse macrophages.


Chemical and physical relationships of oncogenic and non-oncogenic simian adenovirus DNA's.


Characterization of temperature-sensitive mutants of adenovirus type 5--serology.


Effects of ionic strength on the release of dengue virus from Vero cells.


Complement profile and C3 proactivator level in serum of healthy children and adults in Thailand.


The growth of Pseudomonas aeruginosa, in normal saline solution and tap water.


Demonstration of specific antigen in N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide induced rat bladder tumor.


Pharmacologic study of cefazolin in volunteers.


Spherules in the serology of Coccidioides immitis. II. Complement fixation tests with human sera.


Metabolism and kinetics of the hypoglycemic agent glipizide in man--comparison with glibenclamide.


Cromolyn sodium (disodium cromoglycate) in treatment of asthma.


Diagnosis of listerial infections in infants.


Modern principles of the use of fat emulsions in parenteral nutrition.


Metabolism of xenobiotics by strains of intestinal bacteria.


Trichomonas and yeast vaginitis in institutionalized adolescent girls.


Bacterial contamination of children's soap bubbles.


Gonorrhea and the pediatrician.

Gonorrhea and the pediatrician.


Repeated pulmonary embolism in an infant with subacute Candida endocarditis of the right side of the heart.


Trimethadione (Tridione)-induced nephrotic syndrome. A report of a case with unique ultrastructural renal pathology.


Dermographia mediated by immunoglobulin E.


Serum beta-glucuronidase activity in diabetic patients as related to vascular complications and degree of glucose metabolic disorder.


Therapy of acute meningococcal infections: early volume expansion and prophylactic low dose heparin.


Intrapulmonary lipoma associated with multiple pulmonary hamartomas.


Intraluminal diverticulum of the duodenum.


The aetiology and prevention of pancreatitis following biliary-tract operations.


A 'corrugated' extrahepatic bile-duct: a new cholangiographic picture.


The risk of Rh isoimmunization in ruptured tubal pregnancy. In 9 (24%) out of 38 African women who had suffered a ruptured tubal pregnancy significant numbers of fetal erythrocytes (5 or more per 150,000 maternal cells) were found in the maternal circulation. This is a higher incidence than occurs after abortion and indicates that rupture of a tubal pregnancy is a potential source of Rh isoimmunization. The finding of fetal cells in the peritoneal cavity suggests that this is the main source of the fetal blood found in the maternal circulation. At operation on Rh-negative patients with ruptured tubal pregnancies, therefore, complete removal of the peritoneal blood should be attempted and the blood recovered should never be transfused into the patient, who should always receive prophylactic Rh immunoglobulin.


Diabetes mellitus: the thin maturity-onset diabetic.


Medulloblastoma--treatment and prognosis. A study of seventeen cases in ten years. In a series of 17 biopsy-proved cases of medulloblastoma all patients were treated by megavoltage irradiation in the Stanford University Division of Radiation Therapy. The entire craniospinal axis was treated in each case. The five-year survival in the series was 27 percent. Two ten-year survivors were studied in detail. The major longterm disability was inhibition of growth of the vertebral column. In this series, a normal tissue nominal standard dose of at least 1275 rets was necessary for tumor control.


An ascending fiber projection from the pontine reticular formation to the hypothalamus in the cat.


The course and distribution of efferents from the tail of the caudate nucleus in the monkey.


Apparent redundancy in the somatosensory system in monkeys.


Tactile discrimination in the monkey after section of the dorsal funiculus and lateral lemniscus.


The influence of nitroglycerin and dipyridamole on pacing-induced S-T segment depression in unanesthetized, atherosclerotic rabbits.


How to recognize von Recklinghausen's disease.


Clorazepate dipotassium, tranxene: anti-anxiety and antidepressant activity.


Anti-trinitrophenyl (TNP) antibody response: suppression by anti-macrophage serum.


Transplacental transfer of polychlorinated biphenyls (Aroclor 1254) in a cow.


Type of relation of coronary vessels to the myocardium and detection of glycogen in the coronary vascular wall of rat, rabbit, pig, bovine and roe.


A histochemical study of glycogen in differentiating central nervous system of chick.


Holographic microscopy.

Holographic microscopy.


Assay of C-cell thyroid adenoma of man for calcitonin activity.


Australia antigen survey in Hungary. I. Healthy blood donors.


Defective lysogeny in Bacillus anthracis Sterne strains.


Electron microscopic localization of alkaline phosphatase in an adenine-dependent mutant of Bacillus anthracis.


Duration and costs of hospitalisation because of orthopaedic infections and proposed cooperation between orthopaedic departments and departments of infectious diseases.


Female aseptic dysuria.

Female aseptic dysuria.


Isotope renography for the diagnosis of urological disorders due to gynaecological radiotherapy.


Pathology of sensorineural hearing loss in otitis media.


Pathogenesis and treatment of facial paralysis due to malignant external otitis.


A mutant of Pseudomonas aeruginosa with increased conjugational ability.


Serum immunoglobulins and antibodies in congenitally athymic (nude) mice.


Ion transport and oxidative metabolism. II. Absence of the enzyme carbonic anhydrase in mitochondria isolated from different tissues of the dog and the rat.


Comparison of the properties of two forms of pyruvate kinase in rat liver and determination of their separate activities during development. 1. Two forms of hepatic pyruvate kinase, designated type L and type M, were distinguished on the basis of kinetic, chromatographic, electrophoretic and immunological criteria. They were partially purified and their properties compared with each other and with the purified enzyme from skeletal muscle. 2. In contrast with type L, the type M enzyme showed no marked evidence of co-operative interactions with phosphoenolpyruvate and was not stimulated by fructose diphosphate. 3. The activity profiles of type L and type M enzymes were determined in developing rat liver by utilizing differences in the kinetic properties of the two forms. The high activity of type M enzyme in the early foetal rat decreased in late gestation and immediately after birth to reach a low value, which remained essentially constant for the remainder of the developmental period. The activity of type L enzyme, in contrast, was low in the early foetal and neonatal liver but increased markedly at the onset of weaning. 4. Possible roles of the two forms of hepatic pyruvate kinase in the control of glycolysis and gluconeogenesis are discussed.


Uterine glycogen metabolism of the rat in early pregnancy.


A cross-reacting embryonic antigen in the membrane of rat sarcoma cells which is immunogenic in the syngeneic host. An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tissue and has the properties to be expected from the well established tumour-specific transplantation-type antigen while the other, referred to as OEA I, was present in all rat sarcomata tested as well as in early embryos. Two other embryonic components were detected in the sarcoma but these were not immunogenic in the rat. The properties of these tumour-associated "antigens" in the membrane of rat sarcomata are summarized below: [Table: see text]


Studies in venereal disease. I. Isolation of L-phase organisms of N. gonorrhoeae from patients with gonorrhoea.


Mutation of gonococci and meningococci in vitro to rifampin (rifampicin) resistance.


Pivampicillin hydrochloride in uncomplicated gonorrhoea.


Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid.


Effect of aflatoxin on the induction of histidase.


Autoradiographic & cytochemical studies of the cytoplasmic deoxyribonucleic acid of Euglena gracilis.


Turbidimetric study of the action of surface active agents on isolated cell walls of Vibrio cholerae.


Influence of subculturing on aflatoxin production by strains of Aspergillus flavus group.


Acute aflatoxicosis: a review.

Acute aflatoxicosis: a review.


Heat resistance of Bacillus subtilis spores at various water activities.


A comparison of various selective media, including a new selective medium for the isolation of brucellae from milk.


Variability of pyocine type and pyocine sensitivity in some strains of Pseudomonas aeruginosa.


The McKee-Farrar total hip replacement. Preliminary results and complications of 368 operations performed in five general hospitals.


Traumatic aneurysm of perforating peroneal artery. Arterial bleeding--cause of severe pain following inversion, plantar flexion, ankle sprains.


Characteristics of aldosterone stimulated transport in isolated skin of the toad, Bufo bufo (L.).


Aldosterone induced morphological changes in amphibian epithelia in vivo.


Hormonal influences on transepithelial sodium transport: aldosterone vs. insulin.


Hyperosmolar non-ketotic coma in a kidney transplant recipient.


Immunological and histochemical evaluation of marrow aspirates in patients with prostatic carcinoma.


Multiple and recurrent epithelial tumors of the bladder in a child.


Direction of SPP1 DNA replication in transfected B. subtilis cells.


Fate of transforming DNA following uptake by competent Bacillus subtilis. VI. Non-covalent association of donor and recipient DNA.


Interspecific transformation of rifampicin resistance in the genus Bacillus.


Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults.


Radiotherapy of Hodgkin's disease.

Radiotherapy of Hodgkin's disease.


Acute salpingitis in pregnancy.

Acute salpingitis in pregnancy.


Some observations on the pathogenesis and morphology of giant cell granulomas.


Antibodies against melanin. The significance of negative results.


Edward Livingston Trudeau, M.D.

Edward Livingston Trudeau, M.D.


A contribution to the detection of inapparent rabies in stray dogs. Occurrence of precipitating antibodies in sera and antigens in salivary glands and saliva.


Vomiting and diarrhoea in dogs.

Vomiting and diarrhoea in dogs.


Hereditary diseases--causes, cures, and problems.


Automated determination of total phenol in urine.


Structure and function of ferritin.

Structure and function of ferritin.


Imidophosphates as new nucleotide derivatives.


New derivatives of thymidine 3',5'-cyclophosphate.


N-sulfenylamino acid N-carboxyanhydrides.


Alkaline condensation of emodin to isohypericin: a simple synthesis of the meso-naphthodianthrone (phenanthro(1,10,9,8-opqra)perylene) system.


Some functional characteristics of the superior colliculus of the rhesus monkey.


The role of the superior colliculus in visually-evoked eye movements.


Frontal eye-field lesions in monkeys.

Frontal eye-field lesions in monkeys.


Cerebellar ablations and spontaneous eye movements in monkey.


Unit activity in the brainstem related to eye movement. Possible inputs to the motor nuclei.


Neurophysiological correlates of eye movements in the visual cortex.


Central programming and peripheral feedback during eye-head coordination in monkeys.


Comparative physiology of movement-detecting neuronal systems in lower vertebrates (Anura and Urodela).


Concerning the supranuclear organization of eye movements.


Quantitative studies on optokinetic nystagmus in the monkey.


The origin of quick phases of nystagmus in the horizonatal plane.


Extraocular proprioception and muscle function.


The behavior of eye movement motoneurons in the alert monkey.


Measurement of growth hormone synthesis by rat pituitary cells in culture.


Purification, characterization and comparison of immunological properties of monkey chorionic somatomammotropin with human and monkey growth hormone, human chorionic somatomammotropin and ovine prolactin.


Cyclic variations of serum progestins and immunoreactive estrogens in marmosets.


Functional luteolysis in the rhesus monkey; the role of estrogen.


Effect of synthetic TRH on serum prolactin, TSH and milk production in the cow.


Progesterone studies in the Macaca fascicularis.


The effects of four mercury compounds on the generation time and cell division in Tetrahymena pyriformis, WH14.


Ingestion and absorption of naturally occurring pteroylmonoglutamates (folates) in man.


Protein-calorie malnutrition in young Sinclair(S-1) miniature swine.


Production of  167 Tm for medical use.

Production of  167 Tm for medical use.


Distribution of systemic blood flow during cardiopulmonary bypass.


Assessing detergent safety: a comparison of a nonphosphate laundry detergent with phosphate detergents.


The carbohydrate of bovine prothrombin. Partial structural determination demonstrating the presence of  -galactose residues.


Cu ++ -dependent thiol stimulation of glucose metabolism in white fat cells.


Occurrence of N-nonsubstituted glucosamine residues in peptidoglycan of lysozyme-resistant cell walls from Bacillus cereus.


Transcarboxylase. XII. Identification of the metal-containing subunits of transcarboxylase and stability of the binding.


Anti-estrogens and plasma proteins. I. Clomiphene and isomers, ethamoxytriphetol, U-11,100A and U-11,555A.


TSH response to synthetic thyrotropin-releasing hormone in human protein-calorie malnutrition.


Mathematical analysis of body surface potentials.


Absorption, distribution, and metabolic fate of seclazone (7-chloro-3,3a-dihydro-2H,9H-isoxazolo(3,2-b) (1,3)benzoxazin-9-one).


Kinetic analysis of complex formation between penicillin and sucrose.


Marbury virus infection in monkeys. Ultrastructural studies.


Antigenic profile of the rat parotid gland.


The nature of tooth movement.

The nature of tooth movement.


Physiological variation of total-body potassium in man.


Effect of osmotic gradients on intercellular junctions of the toad bladder.


Anderson-Fabry disease.

Anderson-Fabry disease.


Iodine inactivating agent in surgical scrub testing.


Immunoglobulin levels in schistosomiasis.


Congenital tuberculosis successfully treated.


The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs. In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160mug kg(-1) min(-1)) increased acid secretion from Heidenhain pouches to 8.8% and 17.6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs.


A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species. 1. The responses to non-adrenergic, non-cholinergic nerve stimulation have been compared with those to exogenously applied ATP on seventeen different tissues from a number of vertebrate classes.2. Stimulation of all the mammalian gut preparations studied (with the exception of the guinea-pig ileum) after blockade of the effects of adrenergic and cholinergic nerve stimulation by guanethidine (3.5 muM) and hyoscine (1.3 muM) caused inhibition; exogenously applied ATP mimicked this inhibitory response.3. Stimulation of the guinea-pig ileum in the presence of hyoscine and guanethidine, usually caused a diphasic response, relaxation followed by contraction; exogenously applied ATP mimicked this response, in contrast to acetylcholine and noradrenaline which caused excitation and relaxation respectively.4. Stimulation of preparations of lower vertebrate gut and guinea-pig bladder in the presence of hyoscine and guanethidine caused contraction; exogenously applied ATP mimicked this contractile response.5. In each preparation the time course of the response to ATP was similar or identical to the response to non-adrenergic, non-cholinergic nerve stimulation.6. The results are consistent with the hypothesis that a purine nucleotide may be the transmitter substance released from non-adrenergic, non-cholinergic nerves supplying smooth muscle preparations from a number of vertebrate classes.


Induction of male sterility through manipulation of genetic mechanisms present in vector species of Chagas disease. (Remarks on integrating sterile-male release with insecticidal control measures against vectors of Chagas disease).


The pacemaker clinic.

The pacemaker clinic.


Coronary artery occlusion in the conscious dog. Effects of alterations in arterial pressure produced by nitroglycerin, hemorrhage, and alpha-adrenergic agonists on the degree of myocardial ischemia.


Some immunological properties of canine prolactin.


Kanamycin 6'-acetate and ribostamycin 6'-acetate, enzymatically inactivated products by Pseudomonas aeruginosa.


Impaired plasma opsonic activity in malnourished children.


Paraparesis after operation for intrathoracic meningocele. An unknown complication.


Rhinocerebral phycomycosis (mucormycosis).


Therapeutic trial of immunosuppressive agents in multiple sclerosis.


Longitudinal correlative analysis of epileptic baboon, Papio papio.


Wernicke's encephalopathy in uremia.

Wernicke's encephalopathy in uremia.


Punishment of oral-genital self-stimulation in young rhesus monkeys.


Shaping monkey-human contact.

Shaping monkey-human contact.


Short-term intake functions for sucrose in developmentally retarded children.


Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. RNA polymerase was precipitated from extracts of radioactively labeled vegetative and sporulating Bacillus subtilis with antiserum prepared against vegetative core polymerase. The precipitates were solubilized and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Antiserum added to an extract of vegetative B. subtilis precipitated only the known subunits of core RNA polymerase, but antiserum added to an extract of sporulating cells precipitated a new polypeptide of 70,000 daltons in addition to the subunits of core enzyme. The 70,000-dalton polypeptide precipitated from an extract of a mixture of vegetative and sporulating B. subtilis, separately labeled with two different radioisotopes, contained only the radioisotope characteristic of the sporulating cells. The 70,000-dalton protein has been freed of core RNA polymerase and extensively purified by chromatography on phosphocellulose. Precipitation of the purified 70,000-dalton protein by the anti-polymerase serum requires the prior addition of vegetative or sporulation core RNA polymerase. The reaction is specific since the purified protein is not precipitated during antibody precipitation of either phage lambda repressor or bovine serum albumin. The RNA polymerase-binding protein appears during the third hour of sporulation and is apparently not synthesized by the sporulation-defective mutant rfr 10.


Separation of specific segments of transforming DNA after treatment with endodeoxyribonuclease. Hemophilus parainfluenzae endodeoxyribonuclease was used to degrade the DNA of H. influenzae and to follow the biological activity of 14 markers associated with this DNA. It was found that some H. influenzae markers were completely inactivated by endodeoxyribonuclease treatment, while others appeared to retain all or almost all of their original activity. The bulk of the H. influenzae DNA was reduced to double-stranded pieces of the order of 8 x 10(5) to 1 x 10(6) daltons. Velocity sedimentation of the DNA in sucrose gradients disclosed that markers that retained biological activity were present in DNA particles that were of the order of 1 x 10(6) daltons or larger, and indicated a close correlation between the size of the DNA fragment and the amount of biological activity retained. These data suggest that H. parainfluenzae endodeoxyribonuclease breaks DNA at specific sites. The nal(r) marker was shown to have twice as much biological activity after treatment with endodeoxyribonuclease when assayed at saturating DNA concentrations. In the linear portion of the DNA dose-response curve, the biological activity of this marker was reduced 3- to 10-fold compared to untreated DNA (in accord with the reduced size of its DNA). These data demonstrate a specific enrichment of the nal(r) marker by about 6- to 20-fold, and suggest a technique for the separation and purification of specific segments of DNA.


A proposal for the structure of the Drosophila genome. We propose a structure for the genome of Drosophila melanogaster in which each chromatid of each chromomere (band) consists on the average of about 30-35 different sequences of single-copy (unique) DNA, each on the average about 750 base pairs in length. These are separated from one another by stretches of the middle repetitive (reiterated) DNA, which in D. melanogaster makes up about 15% of the genome. These stretches are about 100-150 base pairs in length and are all of the same sequence or family in each individual chromomere and of a different family (sequence) in each different chromomere. Our proposed structure of the Drosophila genome is in accord with all of the known facts concerning the physical chemistry and molecular biology of Drosophila DNA.


Hydroxyphenylazopyrimidines: characterization of the active forms and their inhibitory action on a DNA polymerase from Bacillus subtilis. The active forms of 6-(p-hydroxyphenylazo)-uracil and 6-(p-hydroxyphenylazo)-isocytosine were isolated and identified as their respective hydrazino derivatives. These arylhydrazino pyrimidines selectively inhibited a chromatographically distinct DNA polymerase from Bacillus subtilis. The actions of the reduced drugs on this polymerase were identical to those observed on ATP-dependent DNA synthesis in toluene-treated cells; dGTP competitively antagonized the inhibitory activity of the uracil derivative, and dATP competitively antagonized that of the isocytosine derivative. Analysis of the interactions of the arylhydrazinopyrimidines and nucleic acid bases by nuclear magnetic resonance suggested that hydroxyphenylhydrazino-uracil and hydroxyphenylhydrazino-isocytosine pair in a novel manner with, respectively, cytosine and thymine. A mechanism of inhibitor action, involving binding of the reduced drugs to enzyme and the pyrimidines of DNA template, is proposed.


Potential environmental chemical hazards. II. Feed additives and pesticides.


What's new in surgery. Tumors.

What's new in surgery. Tumors.


What's new in surgery. Shock and metabolism.


The pharmacologic actions of bromochlorodifluoromethane (BCF).


Pseudocholinesterases of mammalian plasma: physicochemical properties and organophosphate inhibition in eleven species.


Biosynthesis of 11 -hydroxyandrostenedione by human and baboon adrenals.


Bacterial surface translocation: a survey and a classification.


Structural studies on the glycolipids from the envelope of the heterocyst of Anabaena cylindrica.


Immunochemistry of sperm-whale myoglobin. Conformation and immunochemistry of derivatives prepared by reaction with diazonium-1H-tetrazole. Evaluation of the specificity of the reagent.


Respiration-dependent transport of carbon dioxide into rat liver mitochondria.


Visual disturbances after missile head injuries.


The at-risk concept as related to young child nutrition programs. A discussion of principles and practice.


The effects of hypnotic drugs on performance.


A possible relationship between the pineal gland and ethanol preference in the rat.


Loxapine: a double-blind comparison with chlorpromazine in acute schizophrenic patients.


Echothiophate in botulism.

Echothiophate in botulism.


A comparative study of loxapine succinate, librium, and placebo in neurotic outpatients.


Experimental studies on the mechanisms of fibrinogen uptake in a rat tumour.


Helper activity of tuberculin-reactive cells on anti-hapten antibody response.


Current research activities on gonorrhea at the Center for Disease Control.


Discrepant equations derived from the single radial immunodiffusion technique.


Preparation of C 14  labelled antibodies.


Sutilains ointment as a topical debriding agent in burns.


Folate distribution in fruit juices.

Folate distribution in fruit juices.


Mung bean nuclease I. V. A tool for probing low melting regions in deoxyribonucleic acid.


Deoxythymidylate phosphohydrolase induced by bacteriophage PBS2 during infection of Bacillus subtilis.


Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.


Aspiration injection treatment for varus sprain of the ankle. A preliminary report.


Ossicles in the knee menisci. Report of three cases.


A plea for continued opposition to the expansion of duties for dental auxiliaries.


The use of mucosal inserts and insert extensions in difficult maxillary restorative situations.


Dental health education in a school system.


Distal extension partial dentures.

Distal extension partial dentures.


Surgical orthodontics: an approach to profile-plasty.


Crystalline molecular complex of riboflavin tetrabutyrate and N,N-dimethyl-4-aminoazobenzene.


Rectal electrolyte transport and mucosal permeability in ulcerative colitis and Crohn's disease.


Studies on monoclonal antibodies. I. The specificity and binding properties of a Waldenström macroglobulin with anti- G activity.


The detection of microbial antigens.

The detection of microbial antigens.


Combined TAB vaccine.

Combined TAB vaccine.


Highly sensitive method for the assay of plasminogen.


Therapeutic considerations in planning the return of American POWs to continental United States.


Socioeconomic factors and character of Army service.


Case for diagnosis.

Case for diagnosis.


The insulin-obesity syndrome.

The insulin-obesity syndrome.


Studies on development of a vaginal preparation providing both prophylaxis against venereal disease, other genital infections, and contraception. I. Venereal disease prophylaxis, past experience, present status and plans for future studies.


Neuroleptanalgesia for carotid angiography in neurosurgical patients.


Tuberculin tine test conversion among United States Army enlisted personnel in Vietnam.


Molecular studies of the 5S RNA genes of Drosophila melanogaster. I. Production of chromosomes containing duplications and deficiencies.


Mutations arising during transformation in the blue-green alga Anacystis nidulans.


The administration of chiropractic in the New York City Medicaid program.


In vitro selection for the Hunter gene.

In vitro selection for the Hunter gene.


The genetic control of fumarate hydratase (fumarase) in Drosophila melanogaster.


An evaluation of the biological availability of chloramphenicol.


Polyadenylic acid in Visna virus RNA.

Polyadenylic acid in Visna virus RNA. Visna virus 70S RNA contains long stretches of polyadenylic acid [poly(A)]. The homogeneity in length of poly(4) regions is observed in 70S RNA from visna virus and all RNA tumor viruses tested, and not with other types of RNA. By this criterion visna virus resembles RNA tumor viruses.


Observations of apparent C-type particles in baboon (Papio cynocephalus) placentas. Ultrastructural investigations have revealed the presence of apparent endogenously derived C-type particles in the placental villi of each of 13 baboons studied. Both budding and mature forms were observed in the syncytiotrophoblast of these animals at various stages of pregnancy.


Houston MD tackles football injuries.

Houston MD tackles football injuries.


Lethal drug interactions.

Lethal drug interactions.


Propanidid (Sombrevin), an anaesthetic of quick action.


The control of pulmonary sepsis in intensive therapy units. A study at the Brompton Hospital, London.


Incidence and identification of Pseudomonas fluorescens and Pseudomonas putida in the clinical laboratory. Strains of Pseudomonas producing fluorescin but no pyocyanin or pyorubrin were studied by biochemical and antibiotic sensitivity testing. A rapid nitrate test was found to be useful in distinguishing P. aeruginosa (positive) from P. fluorescens and P. putida (both negative). A shortened gelatin test differentiated P. fluorescens (positive) from P. putida (negative). P. fluorescens and P. putida were very sensitive to low levels of kanamycin and resistant to carbenicillin, a pattern just the opposite of that obtained with P. aeruginosa.


Effects of some disinfectants on African swine fever virus. Ten commercially available disinfectants were tested at high pH in 2% sodium hydroxide and low pH in 2% acetic acid as inactivants for African swine fever (ASF) in a protein-rich blood-spleen homogenate. As assayed in leukocyte cultures, sodium hydroxide and acetic acid, sodium meta silicate and Roccal did not inactivate ASF virus in 1 hr at 22 to 25 C. Some viricidal activity as assayed in leukocyte cultures was found with Weladol, Triton X-100 Amphyl, pHisoHex, sodium dodecyl sulfate, LpH, Environ, Environ D, and One-Stroke Environ. Of these, the last four appeared to be most promising. When assayed in pigs, only One-Stroke Environ (1/E) was viricidal. Concentrations of 1.0, 0.75, and 0.5 were effective, but, at 0.25%, virus was not inactivated. The minimal time to inactivate ASF virus by 1% 1/E is 60 min. A room contaminated with ASF virus was made safe for pigs after 1 hr by spraying with 1% 1/E. The most active component of 1/E is o-phenylphenol. Although another component of 1/E, i.e., o-benzyl-p-chlorophenol, also has some activity, the mixture of the active components of 1/E is most effective against ASF virus. One of the soluble antigens associated with ASF virus is destroyed by 1/E.


Accumulation of only aflatoxin B 2  by a strain of Aspergillus flavus. A strain of Aspergillus flavus isolated from ground black pepper produced only aflatoxin B(2) on several natural substrates.


Microbial toxicity of isopropyl myristate used for sterility testing of petrolatum-based ophthalmic ointments. The toxicity of isopropyl myristate (IPM) to microorganisms varies from lot to lot and between manufacturers. The toxicity is not directly proportional to the number and level of IPM homologues present nor to the small quantities of fatty acids, alcohols, aldehydes, or ketones found in both filter- and heat-sterilized IPM. The toxicity of IPM, both filter- and heat-sterilized, has no correlation with the usual physical and chemical characteristics of IPM but shows excellent correlation (correlation coefficient, r = 0.88) with the pH of a water extract of IPM. The toxic compounds can be removed and the toxicity of both filter- and heat-sterilized IPM can be reduced by basic alumina treatment. These findings may indicate that trace amounts of acidic catalysts remaining after production of IPM are responsible for the toxic effect.


Microtissue culture test for the titration of low concentrations of diphtheria antitoxin in minimal amounts of human sera. A microtissue culture method for the assay of low concentrations of diphtheria antitoxin in human sera has been developed, using a monkey kidney cell (VERO) culture technique. Results obtained with sera from nonvaccinated children and with immune sera from children vaccinated with three and four injections of diphtheria pertussis tetanus vaccine were in agreement with antitoxin levels considered necessary to denote immunity to diphtheria. The use of microplates and organic buffer for culturing the animal cells improved the stability of the tissue culture system. The described method is sensitive, economical, and applicable for the titration of antitoxin in human sera particularly from infants and children from whom a minimum amount of serum is available.


Characterization of a heat-stable protease of Pseudomonas fluorescens P26. A heat-stable, extracellular proteolytic enzyme was isolated from Pseudomonas fluorescens P26. Brain heart infusion broth (Fisher Scientific Co.), pH 7.5, and incubation at 21 C provided the optimal conditions for bacterial growth for enzyme production. The organism had a D value of 2.6 min at 62.8 C (145 F). The enzyme, however, was quite heat-stable, requiring 15 hr at 62.8 C, 8 hr at 71.4 C, and 9 min at 121 C for complete inactivation. Milk, whey, and casein each had a protective effect on the enzyme against heat inactivation. Purification was accomplished by growth of organisms in broth, centrifugation, sterilization by filtration, ammonium sulfate precipitation (55% saturation), dialysis (against six changes of water), and protein separation by passage through a Sephadex G-100 column. Ultracentrifugation revealed a single band with a sedimentation coefficient of 1.51 which suggested a molecular weight of approximately 23,000. As little as 0.2 unit of the purified enzyme caused detectable flavor defects during 30 days of storage at 4 C, and the Hull test for liberation of tyrosine compared favorably in sensitivity with the sensory method in milk.


Survival of animal tissue cells in primary culture in the absence of serum. The ability of cells from tissues of several species of animals to survive in primary culture without serum was tested. Of the species tested, cells from the kidneys of Macaca mulatta (rhesus) and Cercopithecus aethiops (vervet) monkeys and chicken embryo cells not only survived under these conditions, but indeed developed into confluent monolayer cultures. The addition of either serum or its globulin or albumin fraction enhanced the development of cell monolayers and permitted those cells unable to survive in the absence of serum to do so. Certain specific protein trypsin-inhibitors not of serum origin were unable to provide conditions necessary for cell survival or growth when used in place of serum proteins.


Tuberculin activity of mycobacterial fractions obtained by chromatography. Commercial purified protein derivatives (PPD), old tuberculin (OT), the bacillary extract, and the culture filtrate of Mycobacterium tuberculosis H37Ra were submitted to Sephadex G-25 and diethylaminoethyl (DEAE)-cellulose chromatography. The ability of the fractions obtained to elicit delayed dermal hypersensitivity in M. tuberculosis H37Ra-infected guinea pigs was studied. Skin tests with Sephadex fractions in M. tuberculosis H37Ra-infected guinea pigs showed that the tuberculin activity was localized in the first fraction. All other Sephadex fractions were nonessential and nonspecifically irritating. Fractions from chromatography of Sephadex G-25 fraction 1 on DEAE-cellulose columns showed that all but the first were able to elicit delayed hypersensitivity reactions. There was a variability in the capacity to elicit the tuberculin reaction according to the fraction injected and the stage of tuberculous infection in guinea pigs. Compared to the others, the seven lots of commercial PPD were variable in composition and content. They contained both essential and nonessential materials for the tuberculin reaction. Sephadex fraction 1 would appear to be a better tuberculin as it excludes nonessential nonspecifically irritating elements and contains the complement able to elicit the tuberculin reaction. Its methodological simplicity would be economically advantageous.


Survival of airborne bacteria in a high urban concentration of carbon monoxide. Vegetative cells of Serratia marcescens 8UK, Sarcina lutea, and spores of Bacillus subtilus var. niger were held in aerosols, with and without an urban concentration of CO (85 muliters per liter or ppm), for up to 6 hr at 15 C and a relative humidity (RH) of approximately 0, 25, 50, 75, and 95%. It was found that CO enhanced the death rate of S. marcescens 8UK at least four- to sevenfold at low RH (ca. 1 to 25%), but protected the cells at high RH (ca. 90%). Death rates of S. lutea, with or without added CO, were comparatively low over the entire RH range. However, in the first hour, airborne S. lutea held in CO-containing air were more stable than those in air without added CO (i.e., CO protection). A marked increase in the death rate (up to 70-fold) occurred in the subsequent 5 hr within the RH range of approximately 0 to 75%. Statistical analysis indicated that aerosol decay rates of B. subtilus var. niger spores decreased significantly, when held in a CO-containing as compared to a non-CO-containing atmosphere, in the 0 to 85% RH range. Thus, the data presented indicate that CO in the urban environment may have a protective or lethal effect on airborne bacteria, dependent upon at least the microbial species, aerosol age, and relative humidity. A mechanism for CO death enhancement and protection of airborne S. marcescens 8UK is suggested to involve CO uncoupling of an energy-requiring death mechanism and an energy-requiring maintenance mechanism at high and low RH, respectively.


Influenza A neuraminidase antibody assay with sensitized erythrocytes. Erythrocytes sensitized with purified neuraminidase (Hong Kong) antigens were used for assay of influenza A neuraminidase antibodies. The neuraminidase indirect hemagglutination test was equal to the neuraminidase hemagglutination-inhibition (enhancement) test and appeared to be better than the neuraminidase inhibition test for detection of fourfold or greater antibody rises in paired sera from influenza patients or vaccinees. It was better than both tests for detection of neuraminidase antibody. The neuraminidase indirect hemagglutination test is simple to perform and has the advantage of direct antigen-antibody assay.


Identification and characterization of Acholeplasma oculusi spec. nov. from the eyes of goats with keratoconjunctivitis.


Feline cutaneous mastocytomas.

Feline cutaneous mastocytomas.


Listeria monocytogenes meningitis. Report of a case and review of the literature.


An effective treatment of hypercholesterolaemia. Use of a combination of a bile acid sequestrant and clofibrate.


Hepatitis: a review of the disease and its prevention.


The medical treatment of angina pectoris. IX. The medical management of angina pectoris.


Biochemical mechanisms of salicylate teratology in the rat.


Metabolic changes in Bufo arenarum oocytes induced by oviducal secretions.


The homoeotic effect of "tumorous head" in Drosophila melanogaster.


Collie eye anomaly: decreased prevalence through selective breeding.


Twenty years of progress in Public Health in Mississippi.


Proliferative epithelial lesions of the urinary bladder of nonhuman primates infected with Schistosoma haematobium.


Morphological and biophysical properties of the Mason-Pfizer monkey virus.


Morphology of simian foamy viruses, with particular reference to virus isolated from spontaneous tumor of a rhesus monkey.


The multiple use of RhoGAM.

The multiple use of RhoGAM.


Operant behavior in the morphine-dependent rhesus monkey.


Regional blood flow changes during norepinephrine, tyramine and methoxamine infusions in the unanesthetized rhesus monkey.


Pharmacologic properties of minoxidil: a new hypotensive agent.


Mechanism of tolerance development to organic nitrates.


The hemodynamic effects of beta adrenergic blockade on the flow-dependent hepatic clearance of propranolol.


Costal chondritis: an unusual complication in the burned patient.


Septicemia and total parenteral nutrition. Distinguishing catheter-related from other septic episodes.


Constant intravenous insulin infusion in diabetic ketoacidosis.


Routine treatment for diabetic ketoacidosis.


Infection control in total parenteral nutrition.


Some observations on the treatment of snakebites in Vietnam.


The psychological importance of snakes to the combat soldier.


Ventricular aneurysms, including ten-year follow-up of huge aneurysm.


The induction of ovulation with FSH and HCG.


Case for diagnosis.

Case for diagnosis.


G-6-PD deficiency and malaria in Black Americans in Vietnam.


Human-baboon cross circulation in hepatic failure: report of a successful case.


Spontaneous gas peritonitis: a case report.


Focal glomerulonephritis. Experience at Bethesda Naval Hospital.


The challenge of the alcoholic.

The challenge of the alcoholic.


Direct continuous monitoring of liver pO 2  and pCO 2  in partial arterialization of canine liver.


Abdominal surgery. 2.

Abdominal surgery. 2.


Brain uptake of cortisol and cortisone from the CSF and systemic sites.


Unilateral asphyxial brain damage produced by venous perfusion of one carotid artery.


Transient fluent aphasia after acute meningitis.


Cerebral blood flow dynamics in hypotension and cardiac arrest.


Marijuana: effects on deep and surface electroencephalograms of rhesus monkeys.


Galactosamine induced liver injury.

Galactosamine induced liver injury.


Protein-calorie malnutrition and the liver.


An epidemic of picornavirus conjunctivitis in Singapore.


Isolation of Rickettsia tsutsugamushi from rodents, insectivores, carnivores, and ectoparasites from Danang, South Vietnam.


A review of brucellosis in Indonesia with report of a recent case.


Sarcocystis in the Philippines: a histologic review of 202 cases in rats.


An experimental study on the life cycle of Gnathostoma hispidum Fedchenko 1872 in Thailand with special reference to the incidence and some significant morphological characters of the adult and larval stages.


Enhanced phagocytic activity of the reticuloendothelial system in malaria.


Theoretical consideration on the haemolysis of parasitized and non-parasitized red cells in malaria.


Anterior chamber cleavage syndrome. A typical case of Peters' anomaly with primary aphakia.


Sulphenazone sensitivity of some pathogens, and its effect in diseases of the upper respiratory tract.


Mammary secretion of IgG in sows.

Mammary secretion of IgG in sows.


The production and some properties of the brown pigment of Aeromonas liquefaciens.


Full thickness eye wall resection in various species. An experimental approach in treatment of choroidal melanoma.


Practical notes on antibiotic bioassay by the disk method.


Meningococcal pneumonia.

Meningococcal pneumonia.


Membrane-bound thyroglobulin in an experimental thyroid tumor of rats.


Effect of insulin on glycogen synthesis and synthetase enzyme activity in the perfused rat heart.


Aspirin potentiates the hydrosmotic effect of antidiuretic hormone in toad urinary bladder.


Inhibition of cilia regeneration by antineoplastic agents: delay of band migration by vinblastine (NSC-49842), griseofulvin (NSC-34533), and  -peltatin (NSC-24819).


Carbon-13 nuclear-magnetic-resonance studies on selected amino acids, peptides, and proteins.


5-S RNA: investigation of the different extent of phosphorylation at 5'terminus.


A mutant of Lactobacillus acidophilus with temperature-sensitive regulation of DNA synthesis.


Classification of community hospitals by scope of service: four indexes.


Simulation of organisms using a developmental model. 2. The heterocyst formation problem in blue-green algae.


Function of the spleen in controlling infections of Babesia rodhaini in mice.


Some characteristics of a strain of Theileria mutans (Theiler, 1906) isolated from cattle in the county of Kent, England, and maintained in splenectomized calves.


The chemical nature of the egg-shell of helminths. I. Absence of quinone tanning in the egg-shell of the liver fluke, Fasciola hepatica.


Titration of calcium and magnesium in milk with EDTA.


Differential suppressive effect of hydrocortisone on lymphocytes and mononuclear macrophages in delayed hypersensitivity of guinea pigs.


Incontinentia pigmenti. A case report.

Incontinentia pigmenti. A case report.


Visualization of red cell membranes of lysed malaria-infected cells by differential interference microscopy.


The influence of splenectomy on infections of Plasmodium fieldi in Macaca mulatta monkeys.


Plasmodium simium in the Aotus trivirgatus monkey.


Hemoparasite infections in 830 wild animals from the eastern Llanos of Colombia.


Antimicrobial activity of mushroom metabolites.


Electron microscopic localization of a blood-tear barrier to tracer protein in the primate lacrimal gland.


Morquio's disease (mucopolysaccharidosis type IV). Ultrastructure of epiphyseal plates.


The M. masseter of the Formosan monkey.

The M. masseter of the Formosan monkey.


The pathogenesis of the first and second branchial arch syndrome.


Biologic effects of endodontic procedures on developing incisor teeth. II. Effect of pulp injury and oral contamination.


Maintenance of acrylic teeth with decalcified allogeneic bone implanted into fresh extraction sites in monkeys and dogs.


The in-vitro-adsorption of some drugs on antacids.


Transformation of cell cultures derived from human brains.


Clinical applications of Australia-hepatitis-associated antigen.


Concurrent hypoglycemia and lactic acidosis in a diabetic treated with chlorpropamide and phenformin.


Ultrasonic measurements of the living primate eye: the effects of transducer manipulations.


The amount of agar in antimicrobic disk susceptibility test plates.


Infusion fluids as culture media.

Infusion fluids as culture media.


Transferable drug resistance in Pseudomonas aeruginosa and other gram-negative organisms in burns.


Mechanism of late deceleration of the fetal heart rate.


Defluorination of methoxyflurane during anesthesia: comparison of man with other species.


An improved Delves cup atomic absorption procedure for determination of lead in blood and urine.


Cerebral microangiography after hypocarbia and hypercarbia. Demonstration of deep vascular changes produced by Pa CO2  variations in the normal and ischemic brain of the rhesus monkey.


Automated quantitative immunochemical analysis of human immunoglobulins.


Effect of hemolysis on the apparent concentration of insulin in plasma.


Haptoglobin phenotype frequencies in mentally retarded persons.


Modified "calcium base reagent" for simultaneous determination of serum calcium and inorganic phosphate with the "AutoAnalyzer".


Cerebral arteriovenous shunts re-examined.


Fetal deafferentation: the ontogenesis of movement in the absence of peripheral sensory feedback.


Ultrastructure and histochemistry of alumina in cortex.


A possible case of position effect of DNA replication in Drosophila melanogaster. The behavior of T(3;4)10 provides evidence that the centromere of 4 is not in the doublet 101D3,4, and that most of what has been called the left arm of 4 should be called basal 4R. Basal 4R usually does not replicate as much as the tip of 4R when 4 is in its normal position in the chromocenter. Translocated to the tip of 3R, however, basal 4R attains a width equal to that of the rest of the arm-a possible position effect on DNA replication.


Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Aspects of the developmental genetics of lethal and semi-lethal mutants representing 13 complementation groups (cistrons) in the 3A-3C region of the X chromosome of Drosophila melanogaster are given. Each of these cistrons is associated with a particular chromomere in the salivary gland chromosome. Mutants within each cistron have similar lethality patterns and morphological attributes, and the characteristics of a given cistron are distinct with respect to other cistrons. These results provide additional evidence that only one function is associated with each chromomere.-The results of the lethality pattern analysis are also compared with previous studies of lethal mutants of Drosophila.


Genetic consequences of truncation selection at the phenotypic level in Drosophila melanogaster.


Genotype-temperature interaction in Drosophila melanogaster. II. Body weight. The effect of genotype-temperature interactions on body weight has been studied in a natural population of Drosophila melanogaster using four isogenic strains derived from it, and their hybrid F(1) and F(2) progenies. Measurements were made at four constant temperatures-25 degrees , 21 degrees , 17 degrees and 13 degrees C-and at a temperature oscillating between 17 degrees and 25 degrees C.-Low, though significant, genotype-temperature interaction exists among the isogenic strains, but not among the F(1) nor F(2) hybrid progenies. These low interaction values may be due to the fact that all isogenic strains have a common origin and therefore presumably little genic divergence exists among them. F(1) and F(2) hybrid progenies generally exhibit higher homeostasis than the isogenic strains, although one isogenic line has better homeostasis than the majority of the hybrids.-There is no evidence of heterosis and some evidence of dominance. These results are consistent with the hypothesis that body weight is regulated mainly by additive genetic factors and is subject to stabilizing selection.


Congression of unlinked markers and genetic mapping in the transformation of Bacillus subtilis 168. A thorough examination of cotransformation of two unlinked genetic markers in Bacillus subtilis 168 shows that the two recombinational events do not occur randomly. The cotransformation frequency is dependent on the distance between the two markers as well as on the order in which they replicate in the competent cell. These results indicate that uptake and/or integration of DNA molecules bearing these genetic markers is enhanced at the time these markers replicate in the competent cell.


Terminal synthesis of xanthommatin in Drosophila melanogaster. 3. Mutational pleiotropy and pigment granule association of phenoxazinone synthetase. Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), including two which effect other enzymes in the xanthommatin pathway (v, cn), have low levels of phenoxazinone synthetase activity and disrupt the normal association of the enzyme with the pigment granule. A model is proposed depicting several structural and enzymatic interrelationships involved in the developmental control of xanthommatin synthesis in Drosophila.


Regulation of ribosomal RNA gene multiplicity in Drosophila melanogaster. The ribosomal RNA (rRNA) genes of Drosophila melanogaster can undergo a disproportionate replication of their number. This occurs when the cluster of rRNA genes (rDNA) of one chromosome is maintained with a homologous chromosome that is completely or partially deficient in its rDNA. Under appropriate genetic conditions, it appears that disproportionate rDNA replication can be generated at the level of both somatic and germ line cells. In the latter case, mutants partially deficient for rDNA can increase their rRNA gene number to the wild type level and transmit this new genotype to successive generations.


A note on the maternal effect mutants daughterless and abnormal oocyte in Drosophila melanogaster. Two deficiencies for, and a dominant enhancer of, the second chromosome maternal effect mutant, "daughterless" (da), were induced with X-irradiation. Their properties were studied with respect to both da and the linked maternal effect mutant, "abnormal oocyte" (abo), with the following conclusions. (1) The most probable map positions of da and abo are: J-(1/2)-da-2(1/2)-abo, where J is a dominant marker located at 41 on the standard map. (2) The da locus is in bands 31CD-F on the polytene chromosome map; abo is to the right of 32A. (3) Because homozygous da individuals survive while individuals carrying da and a deficiency for da are lethal, it is concluded that da is hypomorphic. (4) From a weak da-like maternal effect in heterozygous da females induced by an "Enhancer of da," we have confirmed a previous report that (a) the amount of sex chromosome heterochromatin contributed by the father can influence the severity of the da maternal effect, and (b) the sex chromosome heterochromatin which influences the da effect is different from that which influences the abo effect. (5) The possibility that da and abo are in a special region of chromosome 2 concerned with the regulation of sex chromosome heterochromatin is strengthened by the observation that the Enhancer of da appears to rescue abnormal eggs produced by homozygous abo mothers. (6) The Enhancer of da is a translocation between chromosomes 2 and 3 with the second chromosome breakpoint in the basal heterochromatin; because the enhancing effect maps in this region of chromosome 2, it is possible that autosomal, as well as sex chromosomal, heterochromatin interacts with da and abo.


Recombination and DNA replication in the Drosophila melanogaster oocyte. A method is described that permits the recovery of a well-synchronized population of oocytes. Utilizing this pupal system, the heat-responsive period for increasing crossing-over in the Drosophila genome has been defined for the X chromosome and a portion of chromosome 2. The response is initiated close to the time of oocyte formation (premeiotic interphase) and is terminated after approximately 36 hr. During the 36-hr period different regions show characteristic responses, which vary in degree, in duration, and in initiation and termination points, so as to generate the beginning of a thermal recombination map for the Drosophila genome. Centromere regions exhibit the greatest increases in crossing-over for their respective chromosomes but are distinctly asynchronous in time; interstitial regions respond the least. Correlated autoradiographic studies have localized DNA replication in the oocyte to a approximately 24-hr period, which also begins close to oocyte formation (premeiotic interphase); late labeling in restricted regions, undetectable with the present method, could extend the period, as could prolonged synthesis in the oocyte. The results demonstrate that DNA replication and the heat-sensitive period for enhancement of crossing-over are coincident processes over most and possibly all of their length.


The effects of  -radiation on Plasmodium knowlesi.


The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro.


Experimental marginal periodontitis in squirrel monkeys.


Adjuvant-polyarthritogenicity of cell walls of mycobacteria, nocardia and corynebacteria.


Chemotherapeutic evaluation of rifampicin to experimental bacillary dysentery in cynomolgus monkeys.


Temperature-sensitive mutants of human adenovirus type 12.


Diabetic hyperosmolar nonketoacidotic coma complicated by mesenteric thrombosis. Case report.


Neuroendocrine factors in the control of primate behavior.


The hypothalamus in pituitary-thyroid regulation.


Gonadal hormones and behavior of normal and pseudohermaphroditic nonhuman female primates.


The effect of melanocyte-stimulating hormone on coat color in the mouse.


Effects of hypoxia on test performance of cebus monkeys.


Arrest of cerebral blood flow and reperfusion of the brain in the rhesus monkey.


Studies on the experimental transmission of Capillaria philippinensis in monkeys.


Early cytochemical changes in the hearts of rats infected with Trypanosoma cruzi.


Drive and performance modification following multiple (light-light) shifts in the photoperiod.


Hyperviscosity syndrome in dysproteinemias.


Sheehan's syndrome and diabetes mellitus: observations on the Houssay phenomenon in man.


Animal-man relationships in today's environment.


Purification and properties of glycogen synthetase from trout liver.


Comparative studies on the vitamin A transporting protein complex in human and cynomolgus plasma.


Characterization of unfolded and compact ribosomal subunits from plants and their relationship to those of lower and higher animals: evidence for physicochemical heterogeneity among eucaryotic ribosomes.


Measurement of immunoglobulins in cerebrospinal fluid employing nephelometric immunoprecipitin techniques.


Immunological studies on the organ and species specificity of ferritin from horse, rabbit and pig.


Comparison of peptide hydrolases from brush border and cytosol fractions of rat and guinea-pig intestinal mucosa.


Central  -adrenergic regulation of growth hormone and insulin.


Triiodothyronine and thyrotropin-releasing hormone interaction on TSH release in man.


Immunological cross-reactivity between human kidney and certain E. coli and streptococcal strains.


An antigenic relationship between human kidney, colon and the common antigen of enterobacteriaceae.


Characterization of thermophilic actinomycetes isolated from residential heating and humidification systems.


Hypermacroglobulinemia associated with heroin use in adolescents.


Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum. Membrane interaction in aggregating cells of Dictyostelium discoideum can be blocked by univalent antibodies directed against specific membrane sites. Using a quantitative technique for measuring cell association, two classes of target sites for blocking antibodies were distinguished and their developmental dynamics studied. One class of these sites is specific for aggregation-competent cells, their quantity rising from virtually 0-level during growth, with a steep increase shortly before cell aggregation. The serological activity of these structures is species specific; they are not detectable in a nonaggregating mutant, but present in a revertant undergoing normal morphogenesis. Patterns of cell assembly in the presence of antibodies show that selective blockage of these membrane sites abolishes the preference for end-to-end association which is typical for aggregating cells. A second class of target sites is present in comparable quantities in particle fractions from both growth-phase and aggregation-competent cells. Blockage of these sites leads to aggregation patterns in which the side-by-side contacts of aggregating cells are abolished. The target sites of aggregation-inhibiting antibodies are suggested to be identical or associated with the molecular units of the cell membrane that mediate cell-to-cell contacts during aggregation. The results indicate that in one cell, two independent classes of contact sites can be simultaneously active.


( 6 N)methyl adenine in the nuclear DNA of a eucaryote, Tetrahymena pyriformis. DNA isolated from macronuclei of the ciliate, Tetrahymena pyriformis, has been found to contain [(6)N]methyl adenine (MeAde); this represents the first clear demonstration of significant amounts of MeAde in the DNA of a eucaryote. The amounts of macronuclear MeAde differed slightly between different strains of Tetrahymena, with approximately 0.65-0.80% of the adenine bases being methylated. The MeAde content of macronuclear DNA did not seem to vary in different physiological states. The level of MeAde in DNA isolated from micronuclei, on the other hand, was quite low (at least tenfold lower than in macronuclear DNA).


Inhibition of DNA synthesis in chick embryo cultures by deprivation of either serum or zinc. The rate of DNA synthesis in cultures of chick embryo cells is proportional to the concentration of serum added. The concentration of serum required to stimulate DNA synthesis increases with cell population density and with the duration of culture after trypsinization. The increase of the serum requirement with population density is not caused by the depletion of serum constituents. The requirement of cells for external zinc in DNA synthesis also increases with population density and duration of culture. The kinetics of inhibition of DNA synthesis by deprivation of serum or zinc are similar. Serum deprivation, however, inhibits 2-deoxyglucose uptake and cell movement, but zinc deprivation does not. The deprivation of either serum or zinc inhibits RNA synthesis about twofold. Very low concentrations of actinomycin D prevent the resumption of RNA and DNA synthesis upon restoration of serum or zinc to deprived cultures.


Basis of behavioral influence of chlorpromazine.


The ontogeny of  14 C-dopamine clearance from the cerebral ventricles of developing Rhesus monkeys.


I. Identification of chemical diabetes. The definition of chemical diabetes.


The reactivity of the spastic arteries.

The reactivity of the spastic arteries.


The time-course of blood-induced spasm of cerebral arteries in baboons.


Pseudomonas aeruginosa in oral infections.


The first Rh-isoimmunized pregnancy.

The first Rh-isoimmunized pregnancy.


Radiotherapy of carcinoma of the cervix following simple hysterectomy.


Hyperalimentation as primary therapy for inflammatory bowel disease.


Large-scale preparation of the human carbonic anhydrases.


Quantitative assay for submicrogram amounts of protein.


Single-agent therapy for Hodgkin's disease.


The reactive unit of hemoglobin in hemoglobin-haptoglobin complex formation.


Polymerization of Salmonella, Proteus and Bacillus flagellins in vitro.


Visible and near-infrared circular dichroism of some blue copper proteins.


Carbonic anhydrase: isoenzymes, properties, distribution, and functional significance.


Experimental histoplasmosis in rhesus monkeys. Infectious dose and extrapulmonary dissemination determination.


Allergic bronchopulmonary aspergillosis is not rare. With a note on preparation of antigen for immunologic tests.


Leiomyoma of the esophagus presenting as a bleeding epiphrenic diverticulum.


Allergic bronchopulmonary penicilliosis.


Carbonic anhydrase activity in the mouse uterus during pregnancy, pseudopregnancy, and lactation.


Isolation and characterization of two specific antigens of human seminal plasma.


Genetic studies upon patients treated with isotopes.


Mus musculus and Microtus arvalis in the rice-fields areas as carriers of leptospirae.


An ergot alkaloid preparation (Hydergine) versus papaverine in treating common complaints of the aged: double-blind study.


Modification of bacteriophage phi 25 adsorption to Bacillus subtilis by concanavalin A. The phytohemagglutinin, concanavalin A (Con A), interacts specifically and reversibly with the alpha-d-glucose-substituted polyglycerol phosphate teichoic acids of Bacillus subtilis 168. Teichoic acids from nonglucosylated strains (mutants resistant to phage phi25) interact weakly, if at all, with Con A. Prior treatment of glucosylated cell walls with Con A results in a concentration-dependent inhibition of phage phi25 adsorption. The inhibition of adsorption to glucosylated cell walls occurs immediately upon the formation of the Con A-cell wall complex and is reversed upon dissociation of the complex by addition of alpha-methyl glucose. Examination of the interaction between Con A and whole cells, cell walls, or wall digests from glucosylated (phage-sensitive) and non-glucosylated (phage-resistant) strains further demonstrates the specificity of the reaction. A conditional phage phi25-resistant mutant only forms complexes with Con A when grown under permissive conditions.


Rapid regulation of an anthranilate synthase aggregate by hysteresis. The anthranilate synthase aggregate from Bacillus subtilis is composed of two nonidentical subunits, denoted E and X, which are readily associated or dissociated. A complex of subunit E and X can utilize glutamine or ammonia as substrates in the formation of anthranilate. Partially purified subunit E is capable of using only ammonia as the amide donor in the anthranilate synthase reaction. The stability of the EX complex is strongly influenced by glutamine and by the concentrations of the subunits. Glutamine stabilizes the aggregate as a molecular species in which the velocity of the glutamine-reactive anthranilate synthase is a linear function of protein concentration. In the absence of glutamine the aggregate is readily dissociated following dilution of the extract; that is, velocity concaves upward as a function of increasing protein concentration. Reassociation of the EX complex is characterized by a velocity lag (or hysteretic response) before steady-state velocity for the glutamine-reactive anthranilate synthase is reached. We propose that association and dissociation of the anthranilate synthase aggregate may be physiologically significant and provide a control mechanism whereby repression or derepression causes disproportionate losses or gains in activity by virtue of protein-protein interactions between subunits E and X.


Channel-shuttle mechanism for the regulation of phenylalanine and tyrosine synthesis at a metabolic branch point in Pseudomonas aeruginosa. A bifunctional protein complex was partially purified from Pseudomonas aeruginosa. Catalytic activities for chorismate mutase and prephenate dehydratase coeluted from gel filtration and DEAE-cellulose chromatography columns. The protein complex had a molecular weight of approximately 134,000, as determined by gel filtration. In crude extracts or in partially purified preparations about one-half of the chorismate utilized by the complex is converted to phenylpyruvate, and the other half accumulates as prephenate. The chorismate mutase activity is strongly product-inhibited by prephenate, competitively with chorismate. Accordingly, the first reaction of the complex can be sufficiently retarded by prephenate so that all of the reaction product is phenylpyruvate. Chorismate mutase activity is also competitively inhibited by phenylalanine. Although phenylalanine is effective at low concentrations, maximal inhibition is only 50 to 60%. Inhibition of chorismate mutase by phenylalanine was completely lost after gel filtration. The prephenate dehydratase activity of the protein complex is nearly completely inhibited by 0.1 mm phenylalanine in either crude extracts or partially purified preparations. A second species of prephenate dehydratase was separated from the prephenate dehydratase-chorismate mutase aggregate by gel filtration or anion exchange chromatography. The second prephenate dehydratase had an estimated molecular weight of 76,000, a high affinity for prephenate, and was insensitive to feedback inhibition by phenylalanine. The physiological role of the latter enzyme is uncertain. The other regulatory enzymes of tyrosine and phenylalanine biosynthesis, prephenate mutase aggregate by gel filtration or anion exchange chromatography. The other regulatory enzymes of tyrosine and phenylalanine biosynthesis, prephenate dehydrogenase (molecular weight of 120,000) and 3-deoxy-d-arabino-heptulosonate-7-phosphate synthetase (molecular weight of 52,000), elute from Sephadex G-100 columns as fractions which are distinct from both the chorismate mutase-prephenate dehydratase complex and from the low-molecular-weight species of prephenate dehydratase. A shuttle mechanism governing the metabolic fate of prephenate (to phenylalanine or to tyrosine) is proposed in the context of a model which also accommodates several previously puzzling findings: (i) the dominating role of tyrosine in the control of 3-deoxy-d-arabino-heptulosonate-7-phosphate synthetase and (ii) the lack of feedback control of prephenate dehydrogenase by tyrosine.


Development of a quantitative immunological assay for the study of spore coat synthesis and morphogenesis. A quantitative assay employing (125)I-labeled antibody has been developed for Bacillus cereus T spore coat protein. Populations of antibody molecules with various affinities for inner or outer coat can be prepared by selective adsorption to and elution from different coat preparations. Adsorption to and elution from intact spores results in an antibody preparation at least 15 times more reactive to outer coat. This antibody is useful for measuring the time and extent of spore coat maturation, i.e., outer spore coat formation. Rifampin inhibits the increase in content of this coat antigen.


Phycobilisomes in Anacystis nidulans.

Phycobilisomes in Anacystis nidulans. Phycobilisomes were demonstrated in Anacystis nidulans by chemical and morphological studies on cells grown in red light. These cells showed a marked reduction in the chlorophyll-phycocyanin ratio owing to a decreased chlorophyll content. Granular structures of approximately 35 nm were observed throughout red light-grown cells, but were most distinct in the peripheral region. The presence of phycobilisomes in cells grown in red light as well as in cells grown in white light is supported by experiments in which glutaraldehyde was used to stabilize the attachment between the phycobiliprotein and the thylakoids, allowing the isolation of both in the same fraction by sucrose density gradient centrifugation.


Metabolism and pharmacokinetics of a new nonsteroid, anti-inflammatory agent, 2-(3-chloro-o-toluidino) nicotinic acid (clonixin) in rats, dogs and monkeys.


Studies on the metabolism of some chemical species of radioruthenium in the rat. I. Early fate of ingested ruthenium.


Statement of aims of the committee and the costs of medical care, its causes and controls.


Effect of gene dosage on level of alcohol dehydrogenase in Drosophila.


Chromosomal studies in the squirrel monkey.


The value of the leucinaminopeptidase test in the early diagnosis of foetopathies.


Uptake of L-thyroxine-I 131  by the tissues of mice at various reproductive conditions.


Caloric vestibular stimulation via UHF-microwave irradiation.


Pseudomonas arthritis and osteomyelitis.


Studies on gonococcus infection. 3. Correlation of gonococcal colony morphology with infectivity for the chick embryo. Comparable numbers of types 1, 2, 3, and 4 gonococci were placed on the intact chorioallantoic membrane of 236, 10-day old chick embryos. Types 1 and 2 organisms produced infection and could be cultured from chorioallantoic fluid 2 days later significantly more often (69%) than types 3 and 4 organisms (12%, P < 0.001). This confirms in an animal model the same correlation between colony types and infectivity observed in human volunteers and suggests that types 1 and 2 gonococci possess a fundamental virulence characteristic which is absent from types 3 and 4 organisms. Gonococcal infection of the chick embryo chorioallantoic cavity remains a useful model somewhat analogous to localized gonococcal infection in man.


The effect of cytoplasmic proteins on the reaggregation of dissociated ghost membranes of Bacillus megaterium KM.


New concept on atherogenesis and treatment of atherosclerotic diseases.


Triiodothyronine (T3) radioimmunoassay. A critical evaluation.


Behavioral aspects of drug dependence.

Behavioral aspects of drug dependence.


Marihuana. What type of problem.

Marihuana. What type of problem.


Effects of inhibitors on repair of DNA in normal human and xeroderma pigmentosum cells after exposure to x-rays and ultraviolet irradiation.


Modification of radiation-induced genetic damage in the male germ cells of Drosophila melanogaster with pyrimidine nucleosides and their halogenated analogues: effects on the F 1  generation.


Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study.


Committee on maternal welfare. Diabetes and cardiac arrest.


Measurement of the glomerular filtration rate.


Regulation of menstrual cycle and termination of pregnancy in the monkey by estradiol and PGF2 alpha.


Stimulatory effects of prostaglandins upon luteinization of rhesus monkey granulosa cell cultures.


Effects of prostaglandin inhibitors, 7-oxa-13-prostynoic acid and eicosa-5,8,11,14-tetraynoic acid, upon luteinization of rhesus monkey granulosa cells in culture.


The effect of prostaglandin F2 alpha in the closure of the ductus arteriosus.


The possible mode of action of prostaglandins. IV. Reversal of the detrimental effects of prostaglandin E2 in the termination of decidual growth in pseudo-pregnant rats by using prolactin or progesterone.


Release of glucagon, induced by stress.

Release of glucagon, induced by stress.


Clinical experience with hypothalamic releasing hormones. 1. Thyrotropin-releasing hormone.


Preservation of cerebral function during circulatory arrest and resuscitation: hypothermic protective considerations.


Hypothermia--two syndromes, the early hypothermia and the late hypothermic cardiac arrest.


Recent progress in oesophageal surgery.

Recent progress in oesophageal surgery.


Tuberculosis of the penis.

Tuberculosis of the penis.


Nutritional support of patients with intravenous hyperalimentation.


Estrogen formation in the brain.

Estrogen formation in the brain.


Antibacterial activity of human amniotic fluid.


The effects of hypoxia on placental glycogen metabolism.


IgM antibodies to red cells and autoimmune anemia in patients with malaria.


The challenge of drug-resistant malaria.


Plasmodium cynomolgi malaria: accidental human infection.


Infectivity of Plasmodium berghei and of Babesia rodhaini to various primates.


Survival of Dengue virus in post mortem samples of tissues from experimentally infected Rhesus monkeys.


Laboratory transmission of Chikungunya virus by Aedes (Stegomyia) apicoargenteus Theobald (Diptera, Culicidae).


Brain scans in autopsy proved cases of intracerebral hemorrhage.


Fatty liver induction: effect of ethionine on polyunsaturated fatty acid synthesis.


The effects of temperature and fatty acid structure on lipid metabolism in Bacillus licheniformis.


Purification and some properties of lysophospholipase from Penicillium notatum.


Some properties of phospholipases of alveolar macrophages.


Bursa-dependent lymphocyte function in established cell lines: an in vitro model for the study of immunoglobulin and specific antibody synthesis.


The oncogenicity of cell cultures isolated from normal subjects and from patients with infectious mononucleosis, Letterer-Siwe disease or Hodgkin disease.


Retinol-binding protein (RBP) and pigmentary dystrophy of the retina.


Radiochemical methods for the assay of alpha-amylase, glycogen synthetase and phosphorylase in the human endometrium.


Alpha-amylase, glycogen synthetase and phosphorylase in the human endometrium: influence of the cycle and of the Cu-T device. Activity of alpha-amylase (E.C.3.2.1.1.), glycogen-synthetase (E.C.2.4.1.11.) and phosphorylase (E.C.2.4.1.1.), protein content and date of endometrial biopsy specimens from 8 normally menstruating women (ages 23-33) were determined and  plasma progesterone assayed at different phases of the menstrual cycle for 3 cycles before and after the insertion of a Copper-T intrauterine device.  Agreement between cycle day, histological dating, and plasma progesterone levels were consistent in control cycles, but discrepancies were found in 6 of 24 cycles with the Copper-T device in situ.  Protein content of the endometrium did not differ due to Copper-T presence.  Alpha-amylase activity of the secretory endometrium was significantly higher than that of the proliferative endometrium both in the absence and presence of the Copper-T device.  Presence of the Copper-T significantly decreased the alpha-amylase activity especially in the proliferative phase, without interfering with cyclic variation in activity.  Glycogen synthetase activity increased gradually with the cycle and reached highest values in the secretory endometrium.  No such increase appeared with the Copper-T device in situ.  Phosphorylase activity was not affected by either the various stages of the cycle or the presence of the Copper-T device.  It is suggested that the Copper-T device interferes with certain phases of the glycogen metabolism of the endometrium.


Dose distribution in the treatment of Hodgkin's disease.


An aortitis in the squirrel monkey and its effect on atherosclerosis.


A comparative study of paraquat intoxication in rats, guinea pigs and monkeys.


Some immunochemical relationships of Aeromonas aminopeptidase.


Selective evolution of phenylacetamide-utilizing strains of Pseudomonas aeruginosa.


Continuous culture studies on the biosynthesis of alkaline protease, neutral protease and  -amylase by Bacillus subtilis NRRL-B3411.


Perivascular oligodendrocytes in the striatum of the squirrel monkey.


An electron-microscopic study of scrapie in the rat: further observations on "inclusion bodies" and virus-like particles.


Effects of steroid pretreatment on development of shock lung. Hemodynamic, respiratory, and morphologic studies.


Unique nature of nitroglycerin tablets prompts regulations.


Enzymatic uricolysis: a study of the effect of a fungal urate-oxydase.


Dissociable IgM-albumin interaction in a case of Waldenström's macroglobulinemia.


The half-life of  131 I-insulin in different groups of patients compared with normal subjects.


Distribution of fluoride and a dilution indicator ( 51 Cr-EDTA) in bacterial suspensions.


Potassium in protein calorie malnutrition.


Extending the scope of nursing practice. Extended role for nurses.


Rhesus incompatibility in obstetrics--prevention-detection & management.


The effect of phosphate on  -amylase production and sporulation by Bacillus subtilis.


The kinetics of product inhibition in the ternary-complex mechanism for enzyme reactions involving two substrates.


Biosynthesis of heparin. I. Transfer of N-acetylglucosamine and glucuronic acid to low-molecular weight heparin fragments.


Histochemical, microscopic and electron microscopic examinations of adrenal cell cortex in two cases of thrombangitis obliterans.


Histochemical studies on phosporylase activity in the tissues of the albino rat under normal and experimental conditions. II. Normal distribution.


Membrane esterases from vertebrate kidney.


Colonization of Spitz-Holter valves by rare bacterial flora.


On the passage of an exogenous diamine oxidase inhibitor to the amniotic fluid.


Gastrointestinal tract reaction to radiation therapy in cancer of the cervix measured by the vitamin A absorption test.


Hepatitis-associated antigen screening by automated complement fixation: comparison with manual methods.


Serologic diagnosis of yeast infections.


A semiautomated microcalorimetric method of antibiotic sensitivity testing.


Intestinal malabsorption in malnourished children before and during recovery. Relation between severity of protein deficiency and the malabsorption process.


Successfully treated nonpuerperal galactorrhea-amenorrhea: a comment on the fallacy of eponymic classification.


Antenatal detection of hemoglobinopathies. A preliminary report.


Effect of cromolyn sodium (disodium cromoglycate) on the peripheral eosinophilia of asthmatic children.


Optokinetic stimulation of an immobilized eye in the monkey.


Fb, a ndw enzymatic fragment of human  G immunoglobulin.


"In vitro" action of rifampicin on typical and atypical mycobacteria.


Optical rotatory dispersion and antibacterial activity of the macro-ring analogues of Gramicidin S.


Absence of naturally occurring coronary atherosclerosis in squirrel monkeys (Saimiri sciurea) treated with chondroitin sulfate A.


Partricin methyl ester, a semisynthetic polyene antibiotic.


A simple in vitro method of characterizing narcotic antagonists.


Twenty-eighth annual meeting of the American Fertility Society.


Uptake and oxidation of glutamic acid in mammalian pancreatic islets.


Characterization of a stable L-form of Bacillus subtilis 168. A stable L-form of Bacillus subtilis 168 (sal-1) has been isolated which grows and divides logarithmically in liquid medium with a generation time of 60 min. This mutant does not synthesize cell wall as evidenced by chemical, biochemical, and morphological analyses. Antibiotics which specifically inhibit cell wall biosynthesis do not affect the growth of the L-form. Significant differences exist between the membrane proteins of the bacillary form and the L-form. The relative profile of membrane proteins varies with the salt concentration of the medium in both the L-form and the bacillary form.


Farnesol metabolism in Drosophila melanogaster: ontogeny and tissue distribution of octanol dehydrogenase and aldehyde oxidase.


Action of interneurons and axon collaterals in cerebellar cortex of a primate.


Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey.


Response to static tilts of peripheral neurons innervating otolith organs of the squirrel monkey.


Resistance of bacteriophage PBS2 infection to 6-(p-hydroxyphenylazo)-uracil, an inhibitor of Bacillus subtilis deoxyribonucleic acid synthesis. 6-(p-Hydroxyphenylazo)-uracil (HPUra), an inhibitor of semiconservative deoxyribonucleic acid (DNA) synthesis in Bacillus subtilis, does not prevent (but slightly reduces the rate of) replication of the uracil-containing DNA phage PBS2. Our observations are consistent with the hypothesis that all B. subtilis phages which are resistant to HPUra are able to induce a new DNA polymerase activity.


Laboratory tests for assessment of rubella vaccines.


Determination of the immunoglobulin class with antibody during natural infection with Salmonella typhi in man.


Some aspects of diseases caused by atypical mycobacteria.


Serum hexosamine, iron and total iron-binding capacity in untreated pulmonary tuberculosis.


Some remarks on atypical mycobacteria in Hungary.


Body fluid shifts in depletion and poststress states and their correction with adequate nutrition.


Suppression of granulocyte and platelet production by pseudomonas burn wound infection.


Serum calcium alterations produced by enterectomy in normal and parathyroidectomized dogs.


The measurement of renal function.

The measurement of renal function.


Nature of urine concentrating mechanism in the macaque monkey.


Influence of coronary blood flow on left ventricular contractility and stiffness.


Respiration and metabolism by homogenates of various types of muscle.


Hydrogen exchange in the synthesis of glyceryl ether and in the formation of dihydroxyacetone in Tetrahymena pyriformis.


L-threonine deaminase in marine planktonic algae. 3. Stimulation of activity by monovalent inorganic cations and diverse effects from other ions.


Structure of immunoglobulin A. Amino acid sequence of cysteine-containing peptides from the J chain.


Kinetics of ribonucleic acid-deoxyribonucleic acid membrane filter hybridization.


Hydroxyapatite chromatography of deoxyribonucleic acids from Euglena gracilis.


Mutagenic properties of benzo(a)pyrene and its methylated derivatives in relation to the molecular mechanisms of hydrocarbon carcinogenesis.


Urinary tract infection and drug response.


Anti-C3a, anti-C3B (anti-B) and their reaction with the anaphylatoxic fragment C3a.


Allotype preference in human Rh antibodies.


A rabbit anti-p-azobenzenearsonate antibody of restricted heterogeneity with light chains of b5 allotype.


Studies on the mechanism of lymphocyte-mediated cytolysis. 3. The role of microfilaments and microtubules.


Immunologic events during Listeria monocytogenes infection in mice: adjuvanticity and immunogenicity of macrophage-bound antigens.


Common enterobacterial antigen. I. Isolation and purification from Salmonella typhose 0:901.


Three new immunologic types of trachoma-inclusion conjunctivitis organisms.


Isolation and characterization of the glycopeptides from a human immunoglobulin M.


Immunoglobulin composition of human antibodies to type 12 streptococcal M protein.


Pathogenesis of Shigella dysenteriae 1 (Shiga) dysentery.


Characterization of bacteria by ultraviolet spectroscopy.


M-components.

M-components.


Aural tuberculosis in childhood.

Aural tuberculosis in childhood.


Putamen: activity of single units during slow and rapid arm movements. The activity of putamen neurons was studied in a monkey during the performance of both slow and rapid arm movements. More than half of all movement-related units discharged preferentially in relation to slow movements and less than 10 percent in relation to rapid movements. These findings indicate that at least a portion of the basal ganglia (the putamen) is primarily involved in the control of slow movements and are consistent with the hypothesis of Kornhuber that the primary motor function of the basal ganglia is to generate slow ("ramp") rather than rapid ("ballistic") movements.


Improved clinical definition of bladder carcinoma by preoperative external radiotherapy.


Hepatitis B antigen: regional variation in incidence and subtype ratio in the American Red Cross donor population.


Stimulation of cell division by membrane-active agents.


A novel aminopeptidase from Clostridium histolyticum.


The number and nature of  , -unsaturated amino acids in subtilin.


Partial purification of a chloroplast DNA polymerase from Euglena gracilis.


The biological activity of some siderochrome derivatives.


Action of lysozyme on oligosaccharides from peptidoglycan N-unacetylated at glucosamine residues.


Membrane mutation related to the production of extracellular  -amylase and protease in bacillus subtilis.


Control of post-operative infection. A comparative evaluation of clindamycin and phenoxymethylpenicillin.


Specific analysis of immunoglobulins. Techniques and clinical value.


Hypothermia in diabetic acidosis.

Hypothermia in diabetic acidosis.


Comparative study of the different methods in detecting Rh antibodies.


Classification of Neisseria meningitidis group B into distinct serotypes. II. Extraction of type-specific antigens for serotyping by precipitin techniques. Over 10 distinct serotypes of group B Neisseria meningitidis have been found to date by using a sensitive microbactericidal assay developed by the authors. The serotype antigens have now been extracted by hot acid or saline extraction procedures. It was found that these extracted serotype antigens may be used in a simple capillary precipitin method. This method uses unadsorbed, undiluted rabbit antisera. In the capillary precipitin method a 3+ to 4+ reaction was considered significant. The microbactericidal assay and capillary precipitin methods for serotyping group B meningococci show excellent agreement. Group B meningococci were also serotyped by an agar gel double diffusion technique. The latter technique conserves reagents and has the further advantage that it does not show the minor cross-reactions observed in the capillary precipitin method. Thus two simple, reproducible methods for serological typing of group B meningococci have been developed. These methods developed for the serological typing of group B meningococci will aid in epidemiological studies of meningococcal disease. They may also be of value for selecting suitable strains for vaccine production.


Function of various intestinal bacteria in converting germfree mice to the normal state. Earlier work had shown that a collection of anaerobic bacteria, in conjunction with facultative anaerobes, may be implanted into germfree mice, thereby rendering the animals "normal" with respect to a variety of parameters tested. The present experiments indicate that a different collection of anaerobic bacteria, isolated from the cecum of normal mice, was necessary to convert germfree mice to the "normal" state when the animals were fed a crude diet, rather than the refined food which had been used in the earlier work. The nature and level of short-chain fatty acids associated with various natural or synthetic "normal" floras in the ceca of mice did not always correlate with the Escherichia coli population present, indicating that fatty acids were not the sole agents inhibiting bacterial populations in the intestine. Experiments are reported which indicate that intestinal anaerobes may under certain circumstances be sufficient to control the populations of other intestinal bacteria such as E. coli. In other instances, such as control of Shigella populations in the mouse intestine, intestinal anaerobes appeared to act synergistically with an E. coli strain, in spite of the fact that the population of the latter was itself suppressed by the anaerobes.


Effects of normal and activated cell fractions on the growth of tubercle bacilli. Fractions prepared from normal and activated liver cells were tested for the antimycobacterial activity by the agar plate diffusion test. Results showed that lysosome extracts of normal and activated cells exerted no antibacterial activity, cell extracts and lysosome membranes exerted some activity, and cell membranes exerted the strongest activity. The active materials of activated cells exerted stronger antituberculous activity than the corresponding materials of normal cells. Degrees of the antimycobacterial activity of various cell fractions showed a close correlation with the amounts of nonesterified fatty acids. This correlation, as well as other data, suggested that the antimycobacterial activity of cell fractions was caused by toxic fatty acids which were produced during the hydrolysis of lipoporteins or phospholipids by the activity of tissue lipases. The relationship of these findings to the mechanism of cellular immunity is discussed.


Effect of vincristine sulfate on Pseudomonas infections in monkeys. In rhesus monkeys, intravenous challenge with 0.6 x 10(10) to 2.2 x 10(10)Pseudomonas aeruginosa organisms caused acute illness of 4 to 5 days' duration with spontaneous recovery in 13 of 15 monkeys; blood cultures became negative 3 to 17 days after challenge. Leukocytosis was observed in all monkeys. Intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate was followed by leukopenia in 4 to 5 days. Intravenous inoculation of 4.2 x 10(10) to 7.8 x 10(10) pyocin type 6 Pseudomonas organisms in monkeys given vincristine sulfate 4 days previously resulted in fatal infection in 11 of 14 monkeys, whereas none of four receiving Pseudomonas alone died. These studies suggest that an antimetabolite-induced leukopenia predisposes to severe Pseudomonas sepsis and that such monkeys may serve as a biological model for study of comparative efficacy of antimicrobial agents.


Experimental Shigella infections in laboratory animals. I. Antagonism by human normal flora components in gnotobiotic mice. Germfree mice were associated with selected species of human intestinal bacteria and then challenged with a streptomycin-resistant Shigella flexneri strain. Antagonism against Shigella was most pronounced in mice associated with Escherichia coli and least pronounced in mice associated with Bacteroides fragilis. A moderate degree of antagonism could be demonstrated in mice associated with either Streptococcus faecalis or Bifidobacterium adolescentis. Shigella persisted in the cecal contents of E. coli-associated mice at very low, stable levels. Shigella populations were reduced to levels below detection in the ceca of mice diassociated with E. coli and Bacteroides. Upon subsequent administration of streptomycin, Bacteroides disappeared from the ceca. The E. coli population was greatly reduced, and Shigella reappeared at very high population levels as an apparent recombinant which resembled E. coli biochemically. A streptomycin-resistant E. coli population subsequently emerged and became dominant in the ceca. Shigella concomitantly declined to levels below detection.


Growth of Streptococcus faecium in the presence of lysozyme. Streptococcus faecium can grow normally in the presence of lysozyme, despite the observation that cell suspensions of the organism are lysed readily by the enzyme. Growth in the presence of lysozyme is not due to resistant cells, and the culture is lysed after growth if the pH of the medium is not allowed to drop too low for lysozyme activity. Growth followed by lysis in the presence of lysozyme was not exhibited by other organisms tested which were either significantly more resistant or more sensitive to lysozyme than S. faecium. Lysozyme was active on the cell wall of S. faecium during growth in the presence of 200 mug of the enzyme per ml in a complex medium. It appears that, when actively metabolizing, S. faecium can synthesize the cell wall at a greater rate than lysozyme can hydrolyze it. Thus, the organism is capable of growth in the presence of the enzyme. A large variation in the lytic responses of enterococcal cell suspensions to lysozyme was dependent on the strain used, the growth phase from which the culture was harvested, and the medium in which the culture was grown.


The hip in heritable conditions of connective tissue.


Indications for orthopedic surgery in the mentally retarded patient.


Effect of immunotherapy on appearance of antibodies to ragweed in external secretions.


Complete dislocation of subtalar and talonavicular joints with talus dislocated off medial side of calcaneus.


Bronchopulmonary fluids in pulmonary alveolar proteinosis.


Semisynthetic  -lactam antibiotics. 2. Synthesis and properties of D- and L- -sulfobenzylpenicillins.


Folate antagonists. 9. 2,4-Diamino-6-((aralkyl)alkylamino)quinazolines, a potent class of antimetabolites with prodigious antimalarial effects.


Novel cephalosporins. Modification of the C-4 carboxyl group.


Simulium congareenarum (Diptera: Simuliidae), a new vector of Leucocytozoon smithi (Sporozoa: Leucocytozoidae) in domestic turkeys.


Cervical myelopathy due to ossification of the posterior longitudinal ligament.


Induced seizures as therapy for experimental stroke in monkeys.


Structure of the human arachnoid granulation.


Removal of an ossified ventral thoracic meningioma. Case report.


Association of ossified subdural hematomas and a meningioma. Case report.


Generalization of habituation between different receptor surfaces of Stentor.


Biomagnetic stressor effects in primates.


Ischaemic heart disease in the elderly.

Ischaemic heart disease in the elderly.


Pretransplant factors and transplant proteinuria in the prognosis of human kidney transplantation. A clinical study of 150 consecutive kidney graft recipients.


The clinical value of amniotic fluid analysis in pregnancies complicated by Rh-isoimmunization or hepatosis.


Hyperimmunoglobulinemia associated with narcotic addiction. Effects of methadone maintenance treatment.


Agammaglobulinemia, absent delayed sensitivity and lymphopenia without infections. A demonstration of immunologic unknowns.


Aids in finding an aide.

Aids in finding an aide.


Membership roster. Arkansas State Dental Association.


Enzyme-immunoassay for the measurement of antigens using peroxidase conjugates.


Detection of faecal occult blood using chlorpromazine as reagent.


Identification and genetic control of two rabbit IgM allotypic specificities.


Prenatal androgenization of females. A review.


Clinical observations on the mechanism of the antidiuretic action of chlorpropamide in vasopressin-sensitive diabetes insipidus and in normal subjects.


A study of the binding of two sulfonamides to carbonic anhydrase.


Fabry's disease (a case report).

Fabry's disease (a case report).


Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells. Attachment of Neisseria gonorrhoeae to amnion cells in tissue culture is facilitated if the gonococci bear pili. This has been determined by studying the number of pilated, colony type 2 gonococci associated with amnion cells after incubation in vitro as compared with the number of nonpilated, colony type 4 gonococci present with amnion cells under the same conditions. These data are supported by light microscope findings. Electron microscope studies provide visualization of fine structure of gonococcal attachment. Gonococci are also found within amnion cells in this in vitro system.


Serum-dependent phagocytosis of paraffin oil emulsified with bacterial lipopolysaccharide. Paraffin oil containing oil red O and emulsified with lipopolysaccharide obtained from Escherichia coli was ingested rapidly by guinea pig polymorphonuclear leukocytes or human peripheral blood granulocytes and monocytes after opsonization by fresh homologous serum. The initial rate of engulfment of the particles was spectrophotometrically assayed by determination of cell-associated oil red O and reflected the opsonic activity of the serum. This activity was resistant to dialysis but labile to heat, hydrazine, and zymosan, required divalent cations, and was maximal in the presence of Ca(++) and Mg(++). It was associated with the fixation of [(125)I]C3 to the lipopolysaccharide particles. Genetically C3-deficient serum had no opsonic activity, and this activity was restored by the addition of purified C3. Normal and C4-deficient guinea pig serum and normal, C2-, and C4-deficient human sera were equally effective in opsonizing lipopolysaccharide particles and lipopolysaccharide particles sensitized with heat-inactivated lipopolysaccharide immune serum. Cord serum deficient in glycine-rich beta-glycoprotein (GBG) (properdin factor B) had diminished opsonic activity which was improved by addition of purified GBG. Thus, C3 fixation to lipopolysaccharide particles occurs by means of the properdin system, and the opsonization and ingestion of lipopolysaccharide particles constitutes a quantitative functional assay of this pathway.


Effect of synthetic thyrotropin-releasing hormone on glucose oxidation and phospholipogenesis in porcine anterior pituitary slices in the presence or absence of thyroid hormone.


Effect of TRH and triiodothyronine on prolactin release in sheep.


Biochemical effects of sucrose acetate isobutyrate (SAIB) on the liver.


Inverse relationship between calcium and ATP in renal tissue of magnesium-deficient rats: a correction.


Lipogenesis from (2- 14 C)glucose in squirrel monkeys.


The effect of formaldehyde and acetaldehyde on the swelling of cells of Pseudomonas aeruginosa in salt solutions and their interactions with amines and carboxylic acids.


Attempted type specific diagnosis of dengue virus infection by the indirect fluorescent antibody method directed at differentiating IgM and IgG responses.


Mutagenicity of primary and secondary carcinogens altered by normal and induced hepatic microsomes.


Macrocranium and neurofibromatosis.

Macrocranium and neurofibromatosis.


The effects of epidural masses on spinal cord blood flow. An experimental study in monkeys.


Parameterization of 4 MV depth-dose data for the Clinac-4 accelerator.


Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease.


Case studies of a clinical pharmacist.

Case studies of a clinical pharmacist.


Instructions to patients taking nitroglycerin.