Circadian rhythm of the resistance of mice to acute pneumococcal infection. The resistance of both male and female mice to an acute infection by type I pneumococci varied rhythmically in an approximately 24-hr cycle. Mice inoculated intraperitoneally with 10(5.4+/-0.1) organisms during the dark period of the daily cycle survived significantly longer than mice similarly inoculated during the light period. The variation in resistance was correlated with the rate of increase of bacteremia, the rate being greatest after inoculation during the light period. Neither the capacity of the blood to support growth of pneumococci in vitro nor clearance of pneumococci from the blood in vivo varied between phases of the daily cycle. Adrenalectomized mice were equally and highly susceptible to infection during both light and dark periods. Stress of mice during the light period, normally a time of relative inactivity of mice, disturbed the rhythm; resistance to infection initiated during the light period increased and equalled that during the dark period.


Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence for mice. Cell walls isolated from two strains of Blastomyces dermatitidis were examined. Whereas strain Ga-1 was practically avirulent for mice, strain KL-1 produced death by 21 days in 50% of the mice inoculated. Analyses of the trypsin-treated cell walls of the two strains revealed a higher chitin and protein content in strain KL-1, whereas a higher polysaccharide content was observed in the cell walls of strain Ga-1. Extraction of the walls with 1 n NaOH revealed a threefold difference in the amount of alkali-soluble cell wall material present. The alkali-soluble material could be further fractionated into a water-soluble and a water-insoluble fraction. Previous reports have indicated that the water-insoluble fraction of B. dermatitidis consists of an alpha-linked glucan; however, we report that in addition a phospholipid moiety is covalently bound to the polysaccharide. Furthermore, on the basis of organic phosphorus content, considerably more phospholipid is associated with the alpha-linked glucan of the more virulent KL-1 strain. These results suggest that this cell wall constituent might be one of the factors related to the virulence of this fungus.


Preferential utilization of the glucosyl moiety of sucrose by a cariogenic strain of Streptococcus mutans. The utilization of sucrose by a cariogenic strain of Streptococcus mutans was studied. The soluble and cell-bound sucrose-dependent, polymer-forming sucrase activities constitutively produced by the bacteria during growth on glucose were measured. About eight times more dextransucrase activity was present than levan-sucrase activity. During various states of growth on sucrose, S. mutans accumulated two to five times more insoluble and water-soluble dextran than levan. Although more of the fructosyl moiety of sucrose was therefore available to the cells, the glucosyl portion of the disaccharide was preferentially incorporated into cellular macromolecules. Glucose was shown to inhibit the utilization of fructose by S. mutans.


Development of tetracycline-resistant Staphylococcus aureus in gnotobiotic mice. Germ-free mice were colonized with a pigmented, tetracycline-sensitive strain of Staphylococcus aureus and maintained in flexible plastic isolators. Treatment of the gnotobiotic mice with oral tetracycline (20 mg/ml) resulted in the development of staphylococci resistant to tetracycline (5 mug/ml or higher). Resistant staphylococci did not appear in feces until several days after exposure of mice to the antibiotic and persisted for as long as specimens were collected (64 days subsequently). Resistance developed after a single exposure of gnotobiotes to antibiotic. Resistant staphylococci were present in the intestinal tracts of mice at counts of 10(3) per g of contents, whereas sensitive organisms coexisted at counts of 10(5) to 10(11) per g. Resistant staphylococci were isolated only from treated mice and not from untreated mice in adjacent cages. Initial colonization of germ-free mice with sensitive staphylococci interfered with subsequent colonization by resistant staphylococci and provided an example of bacterial interference. Resistance to tetracycline was not associated with resistance to chloramphenicol, penicillin, ampicillin, erythromycin, streptomycin, or kanamycin. Hydrolysis of gelatin was the only biochemical characteristic in which isolates varied but was not correlated with resistance to tetracycline or pigmentation of colonies. A nonpigmented, gray variant of S. aureus appeared in all specimens after colonization with the original, pigmented strain. Only the nonpigmented strain was obtained from gnotobiotes colonized with the nonpigmented variant. Contact between bacteria and antibiotic in the intestinal tract of gnotobiotes was considered to be essential for the development of tetracycline-resistant staphylococci.


Characterization of deoxyribonucleic acid from Yersinia pestis by ethidium bromide-cesium chloride density gradient centrifugation. No plasmids were detected in cells of Yersinia pestis which were bacteriocinogenic and positive for three additional determinants of virulence known to be lost at high frequency.


The effects of passive or active warm-up upon certain physiological measures.


Normal pulmonary pressure-flow relationship during exercise in the sitting position.


Body cell mass and physical performance capacity (W 170 ) of school children.


Myoepithelium in the prelactating and lactating mammary glands of the rat.


Myoepithelium in involuting mammary glands of the rat.


Rabbit heart nodal tissue, sinuatrial ring bundle and atrioventricular connexions indentified as a neuromuscular system.


The fine structure of microfibrils and microtubules in macrophages and other lymphoreticular cells in relation to cytoplasmic movement.


Calcification and ossification of fibrocartilage in the attachment of the patellar ligament in the rat.


A method for the study of jaw growth using a computer-based three-dimensional recording technique.


Electrophoretic patterns of strains of Mycoplasma pulmonis.


Cell replacement and differentiation in transitional epithelium: a histological and autoradiographic study of the guinea-pig bladder and ureter.


Failure of erythritol to stimulate the growth of Salmonella dublin in vitro.


Interference between two satellite viruses of tobacco necrosis virus.


Middle ear ventilation and stability in tympanoplastic surgery.


Wildervanck's syndrome. Hereditary malformations of the ear in three generations.


Acoustic impedance studies in tympanoplasty.


Clinical interpretation of tonsillar size.


Embryonal rhabdo-myosarcoma of middle ear: report of a case with 12 years' survival with a review of the literature.


An unusual foreign body in the tracheo-bronchial tree.


Infra-orbital penetrating foreign body.

Infra-orbital penetrating foreign body.


Facial paralysis due to petrous abscess: case report.


Odontogenic keratocyst of the maxilla.

Odontogenic keratocyst of the maxilla.


An unusual hypopharyngeal tumour.

An unusual hypopharyngeal tumour.


Recurrent Bell's palsy.

Recurrent Bell's palsy.


A light and electron microscopic study of sensory organs and associated structures in the foreleg tibia of the cricket, Gryllus assimilis.


An electron microscopic study of the tympanal organ and associated structures in the foreleg tibia of the cricket, Gryllus assimilis.


Anxiety states and depressive neuroses. Issues in nosological discrimination.


Development of electric organs of Gymnarchus niloticus (fam. Gymnarchidae). I. Origin and histogenesis of electroplates.


Suicide in the subway. Publicly witnessed attempts of 50 cases.


Visual evoked response and reaction time during verbal hallucination.


A comparison of the content of mentation reports elicited after nonrapid eye movement (NREM) associated sleep utterance and NREM "silent" sleep.


Selection of psychiatric residents: an overview.


Dynamic changes in cochlear potentials and endolymph concentrations.


European trends in tympanoplasty.

European trends in tympanoplasty.


Tympanosclerosis.

Tympanosclerosis.


Chronic ear disease in aborigines--a research programme.


E.N.T. disease among Australian aborigines. The extent of E.N.T. disease in the aboriginal population of the northern territory.


The hearing status of Australian aboriginal children.


Challenging aspects of ENT disease among aboriginal children.


Clinical stage classification in head and neck cancer.


Transitional cell carcinomatous change in an inverting papilloma of the nose and paranasal sinuses.


Anaesthetic techniques relative to microsurgical procedures on the larynx.


Microlaryngoscopy under neurolept analgesia.


Cervical osteophytes--clinical and radiological findings.


The fascial planes relatd to the postnasal space and the spread of postnasal cancer.


Laryngeal cancer spread.

Laryngeal cancer spread.


Endolymphatic saccotomy in Meniere's disorder.


Some thoughts on Meniere's syndrome.

Some thoughts on Meniere's syndrome.


A reliable electronystagmogram.

A reliable electronystagmogram.


An assessment of the treatment of unilateral deafness.


Complications of chronic suppurative otitis media in Chiang Mai, Thailand.


Middle-ear reconstruction in radical mastoidectomy.


Some thoughts on secretory otitis media.


Cosmetic rhinoplasty--the prerogative of the plastic surgeon or rhinologist.


Rhinoplasty. 2. A plea for the discontinuance of the submucous resection of the septum operation.


The treatment of acromegaly by trans-ethmoidal hypophysectomy.


Xanthomatous pseudotumor of trachea.

Xanthomatous pseudotumor of trachea.


Thrombophlebitis of the cavernous sinus.


Creation of a thoracic duct fistula: an improved technique.


Arterial baroreceptor sensitivity in calves.


The improvement of faculty teaching through evaluation: a follow-up report.


Mortality and morbidity from malaria in countries where malaria eradication is not making satisfactory progress.


The sickle cell trait and leg ulceration.


Physicians vs. hospital costs and beds.

Physicians vs. hospital costs and beds.


Perinatal tips.

Perinatal tips.


Reversible pulmonary thrombosis associated with combination antiovulants.


Tuberculosis--changing concepts.

Tuberculosis--changing concepts.


Current management of the nephrotic syndrome in childhood with emphasis on the role of cyclophosphamide.


Clear-cell adenocarcinoma of the genital tract in young females. Registry report.


The socioeconomics of heroin dependency.


Neonatal onset of the hepatitis-associated-antigen carrier state.


Primary biliary cirrhosis or sarcoidosis--or both.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 51-1972.


Treatment of Bell's palsy.

Treatment of Bell's palsy.


The community-medicine specialist--Britain mandates health service reorganization.


Colchicine for familial Mediterranean fever.


Metabolic responses to levodopa.

Metabolic responses to levodopa.


Serum urate levels.

Serum urate levels.


Verbal blemishes and copy editors.

Verbal blemishes and copy editors.


Genetic counseling: a counselor's view.

Genetic counseling: a counselor's view.


Iron deficiency anaemia and the acid-base variations of exercise.


The uptake of ascorbic acid by the tissues of ascorbic acid-deficient guinea-pigs.


Caloric cost of normal pregnancy.

Caloric cost of normal pregnancy.


Placenta praevia accreta.

Placenta praevia accreta.


Studies on intermittent supplementation. Effect of supplementation of gluten with casein every second or third day on growing rats fed high-protein diets.


The out-of-wedlock pregnancy. Six-years' experience with a university population. Illegitimate births are increasing.  Associated with this increase are higher rates of prenatal deaths and prematurity, in some studies double that of legitamate births.  Marriage after such conception has a higher divorce rate.  The present study includes data on every pregnancy diagnosed at the University of California Santa Barbara Student Health Service during 1965-1971.  It considers the outcome of those pregnancies and reviews some programs that were instituted with an aim toward prevention.  Out-of-wedlock pregnancies decreased after an educational, counseling, and contraception program was instituted.  The rate of abortions remained unchanged in spite of liberalized abortion laws; there were no repeaters after the program was instituted.  Experience in counseling confirms the contention of several authors that some out-of-wedlock pregnancies stem from subconscious reasons.  A multiple disciplinary approach to such pregnancies is advocated.


Uncomplicated subsequent pregnancy after idiopathic fatty liver of pregnancy.


Correlates of repeat induced abortions.

Correlates of repeat induced abortions.


New treatment for the inadequate luteal phase.


Epithelioid sarcoma of the vulva.

Epithelioid sarcoma of the vulva.


Diagnostic, prognostic, and therapeutic considerations in invasive carcinoma of the vagina.


The costs of carcinoma of the cervix.

The costs of carcinoma of the cervix.


The biologic behavior of low-grade papillary serous carcinoma of the ovary.


Aids to vaginal hysterectomy.

Aids to vaginal hysterectomy.


Herpesvirus hominis infection of the female genital tract.


The circulating blood volume of para- and tetraplegics in correlation to serum factors.


The blood pressure in paraplegia. I.

The blood pressure in paraplegia. I.


Sexual function in the normal and in paraplegia.


Pregnancy and labour in the paraplegic.

Pregnancy and labour in the paraplegic.


Sexual and genital prognosis in adult paraplegics.


Marriage and family patterns with long-term spinal cord injury.


Renal osmolal output of patients with acute traumatic paraplegia.


Conservative management of the urinary bladder among children with spinal cord injury.


Conservative management of the urinary bladder in myelodysplasia.


A low molecular weight protein (  2 -microglobulin) and renal disease in spinal cord injury patients.


From the keystone of comedy to the last of the clowns.


Unconscious processes in relation to the environmental crisis.


The therapeutic community in private practice.


Omnipotence of thought and the poetic imagination: Blake, Coleridge, and Rilke.


On selfhood and the development of ego structures in infancy.


Psychoanalysis and history: problems and applications.


Countertransference in the classroom.

Countertransference in the classroom.


Löffler's endocarditis in the organism hypersensitized by Taenia saginata.


The effect of hydrocortisone on the organ cultures of normal and pathologic mucous membranes of human oral cavity.


Vascular-type resorption of bone in cases of maxillary osteodysplasia.


Cell types in the nerve plexus of the small intestine.


Changes in the spleen caused by experimental fractionated local x-irradiation.


Ultrastructural data on different types of hyperplasia and hyperfunction of the juxtaglomerular apparatus.


A quantitative study of the olivocerebellar connections.


Effect of elastase in vitro on small mesenteric arteries of rats with experimental hypertension.


Morphological changes caused by sublimate poisoning in rat liver.


Autoradiographic studies of protein turnover in motoneurons of IDPN-treated rats.


The time course of functional and morphological changes of the guinea-pig colon after "a frigore" denervation of the periarterial sympathetic nerves.


Fine structural changes in the sural nerve of patients with acanthocytosis.


Neuroaxonal dystrophy in subacute dementia. Case report.


Chondrosarcoma of the meninges.

Chondrosarcoma of the meninges.


Differences in pulmonary functions in various racial groups.


Discriminatory risk factors in post-neonatal sudden unexplained death.


The role of social class in human pesticide pollution.


Identification of a type B hepatitis epidemic in Costa Rica. Comparative analysis of two outbreaks of viral hepatitis.


Hepatitis epidemic in a hyperendemic zone of Costa rica. Report of a second outbreak within four years.


Experimental infection of Venezuelan equine encephalomyelitis virus in white-tailed deer.


Pancreatitis in pregnancy.

Pancreatitis in pregnancy.


Observations on the level of blood oxytocinase throughout the course of labor and pregnancy.


Effects of temporary uterine ischemia on the embryo of the conscious rat.


Factors associated with delay in seeking induced abortions.


Maternal plasma estradiol levels in normal and complicated pregnancies.


Alpha fetoprotein in uterine hemorrhage during pregnancy and delivery.


Vaginal bleeding in the midtrimester of pregnancy.


Ureteral function in pregnant women. VI. Bladder and lower ureteral pressures during voiding.


Intravenous prostaglandin F 2   for therapeutic abortion. Clinical use of PG(prostaglandin)F2alpha to perform therapeutic abortion is described.  15 patients, at gestations ranging from 8-17 weeks, were administered PGF2alpha via intravenous infusion.  6 were treated with doses increasing from 25-250 mcg/minute; the other 9 were given a constant dose of between 25 and 100 mcg/minute.  Infusion time ranged from 13.5-33 hours.  6 patients aborted completely with a blood loss estimated to be under 50 cc.  3 patients aborted incompletely and required dilatation and curettage.  6 patients failed to abort and required dilatation and curettage.  No major complications were reported.  Troublesome side effects of nausea, vomiting, and diarrhea were frequent.  These side effects were generally dose-related but capricious in terms of time of occurrence.  The constant lower dose regimen was found to be superior to the graduated dose both in terms of successful outcome and in terms of side effects.  The necessity for long infusion times, the 42% overall failure rate, and the high incidence of side effects led the researchers to conclude that PGF2alpha infusion is not a recommended method of therapeutic abortion; suction evacuation is preferred.


Maternal intravenous glucose administration as a cause of hypoglycemia in the infant of the diabetic mother.


Fetal asphyxia during the intrapartum period in intrauterine growth-retarded infants.


Estriol values in amniotic fluid in the course of normal pregnancy.


Arteriovenous nonesterified fatty acids and glycerol differences in the umbilical cord at term and their relationship to fetal metabolism.


Effect of exogenous estrogen on carbohydrate metabolism in postmenopausal women.


Estrogenic activity in women receiving an injectable progestogen for contraception. 121 multiparous women (aged 15-37) who had received injections of 150 mg of depomedroxyprogesterone acetate (DMPA) every 3 months as a contraceptive for more than 1 year, were examined to assess possible clinical alterations due to low  estrogen levels.  Serum samples were taken to evaluate estradiol levels by radioimmunoassay.  Clinical examination did not reveal any sign of estrogen deficiency, except a smaller uterine than expected.  Serum estradiol concentrations (36-42 pg/ml) were in the range of the follicular phase estradiol levels of the normal ovulating woman.  As this follicular level probably persists throughout treatment, total estrogenic stimulation of end organs was much lower than for cycling women, but greater than for post-menapausal women.  Patients receiving DPMA have functioning ovaries which continue to secrete estradiol at follicular levels.  Uterine atrophy and shift in maturation index during contraceptive treatment with this drug is due to the large dose of progestogen outweighing the low levels of estradiol.  It is suggested that long-term studies are needed to determine the possible advantage of increasing the estrogen effect on end organs over the known adverse effects of estrogen administration.


Studies on serum streptomycin concentrations by intrauterine electrophoresis with streptomycin.


Effectiveness of the Majzlin spring intrauterine contraceptive device.


Factors associated with instillation-abortion time during saline-instillation abortion.


The estrogen-creatinine ratio and the "estrogen index" in normal pregnancy.


Clinical experience with the oxytocin challenge test.


A study of four methods of placental localization.


Amniotic fluid volumes in normal pregnancies.


Teratologic study of rats exposed to ultrasound.


Measurements of Na +  transport in the isolated, artificially perfused guinea pig placenta.


Gestational age and amniotic fluid protein patterns.


Incorporation of leucine- 14 C into proteins of the placenta and liver of mice.


Ultrasonic localization of the Lippes loop.


Depo-medroxyprogesterone acetate as a contraceptive agent: its effect on weight and blood pressure.


Four years' experience with mid-trimester abortion by amnioinfusion.


Effect of the intrauterine contraceptive device upon the biochemical composition of human endometrium.


A new ultrasonic method for transabdominal amniocentesis.


The value of ultrasonic B-scanning in diagnosis when bleeding is present in early pregnancy.


Calcification of fetal teeth as an index of fetal maturation.


Human fetal arousal levels as indicated by heart rate recordings.


The family planning-nurse specialist: an evaluation.


A granulosa cell tumor in tissue culture.


Vaginal hysterectomy for sterilization.

Vaginal hysterectomy for sterilization.


Tubal catheterization: applications of a new technique. The technique of hysteroscopy and tubal catheterization is useful for tubal electrocoagulation, obtaining tubal liquid, recording tubal contraction, and salpingoplasty.  40 patients have been catheterized, with indications of sterilization (20), habitual abortion (7), sterility (5), uterine bleeding (6), and uterine myoma (2).  Except in 7 who required general anesthesia, a paracervical block with 10 ml 1% lidocaine solution is injected at the insertion of the uterosacral ligaments.  After cleansing the vagina and dilating the cervix to Hegar's No. 7, the hysteroscope is inserted into the uterus with the fiber optic light.  Enough 6 or 10% w/v Dextran solution is injected to separate the uterine walls.  The tubal orifices are easily identified, after experience, in most patients, so the catheter can be introduced by direct vision.  Bleeding occurred when glucose or saline was used to dilate the uterus.  Electrocoagulation took 4 to 6 seconds at up to 110w.  The possibility of depositing plastic materials in the tube for optional withdrawal was suggested.  Laparotomy showed that the liquid leaked into the peritoneum.  No complications occurred except minimal discomfort.


Effect of some oral contraceptive steroids on the development of endometrial squamous metaplasia and cysts in rats.


A queuing theory model for the prediction of delivery room utilization.


Toxoplasmosis and pregnancy.

Toxoplasmosis and pregnancy.


Subcontracts for community development and service.


Scanning electron microscopy of the organ of corti after intense auditory stimulation: effects on stereocilia and cuticular surface of hair cells.


Studies on some uterine enzymes in the presence of an intrauterine contraceptive device (IUD) in the rat.


Incoporation of amino acids during maturation in vitro by the mouse oocyte: effect of puromycin on protein synthesis.


Involution of the mammary gland in hamsters.


Corpus cavernosum penis pressure and external penile muscle activity during erection in the goat.


Serial angiography of the crus penis of the goat during erection.


Testis stimulation in hypophysectomized male killifish, Fundulus heteroclitus, treated with mammalian growth hormone and-or luteinizing hormone.


Changes in mouse blastocyst carbon dioxide production as a function of time postcoitum in delay of implantation during lactation or following ovariectomy.


The effects of estrogen and progesterone on the electric activity and intraluminal pressure of the castrated rabbit oviduct.


Fine morphology of human oocyte maturation in vitro.


Myometrium of the pregnant guinea pig: the probable importance of relaxin.


Ivalon (polyvinyl alcohol) sponge in the repair of complete rectal prolapse.


Experiences of Ivalon-sponge implant for complete rectal prolapse at St. Mark's Hospital, 1960-70.


A prospective study of the immediate and long-term results of polya gastrectomy for duodenal ulcer.


An assessment of above- and through-knee amputations.


The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata.


The effect of clothing on the dissemination of bacteria in operating theatres.


Ectopic thymic tissue presenting as a lateral cervical swelling.


Surgical resection of recurrent Crohn's disease.


The management of congenital hydronephrosis in the newborn.


Depression of delayed hypersensitivity and abnormal bone scans in early cancer of the breast.


Lung scans, venograms, and pulmonary embolism.


Absorbable sutures. A comparison between PGA and catgut.


A new principle of extracorporeal respiration.


Non-invasive test of carotid blood-flow: its relevance to transient cerebral ischaemic attacks.


Accelerometry in gait analysis.

Accelerometry in gait analysis.


Design considerations in a new knee prosthesis.


The effect of composition on the corrosion resistance of surgical stainless steel.


Machine for dynamic load testing of internally fixed femoral neck fractures.


Solutions for short-term organ preservation.


Effect of different preserving media on the level of ATP in canine renal cortex.


Studies with a new gastric secretory inhibitor (UK 9040) in the dog.


Studies with a new anti-secretory drug (UK 5850) in rats and man.


Secretin-induced pyloric reflux: verification of the mathematical formula for eliminating reflux in gastric aspirate.


Liver metastases--a clinical study.

Liver metastases--a clinical study.


Antibody production in breast cancer.

Antibody production in breast cancer.


Protective effects of orchidectomy on tumour induction and transplantation in mice.


Macrophage production in response to the growth of an experimental tumour.


Serum-mediated impairment of lymphocyte PHA responsiveness by gut cancer.


Patterns of gastric secretory response to an insulin infusion in vagotomized patients.


The relationship between pylorix reflux and gastric ulcer.


The effect of fat in the duodenum on gastric secretion before and after truncal vagotomy (T.V.) and highly selective vagotomy (H.S.V.) in man.


Effect of truncal vagotomy (T.V.), selective vagotomy (S.V.) and pyloroplasty, and highly selective vagotomy (H.S.V.) without drainage on the response to meat extract in man.


Studies of gastric acid secretion after small-bowel resection.


Radio-isotopic investigation of protein synthesis and reticulo-endothelial activity following partial hepatectomy in the rat.


Mucous change in the duodenum.

Mucous change in the duodenum.


Ovarian implantation into the spleen of normal and portacavally shunted rats.


The effect of insulin on canine bile-secretion and composition.


Prophylactic synovectomy is therapeutic.


A three-phase gas exchanger for blood perfusion of isolated organs.


Peripheral lymphatic pressures in normal subjects.


Lung scans using  131 I human plasminogen.


Small-bowel flora and bowel habit studied at intervals following vagotomy and drainage.


The effect of potassium loading on the intestinal handling of electrolytes.


The role of peritoneal lavage in acute intestinal ischaemia.


Lymphocyte transformation in the mesenteric lymph-nodes in patients with Crohn's disease.


Diverticular disease treated by methyl cellulose tablets.


The effects of dietary supplements of wheat bran and cellulose upon bowel function.


Changes in serum complement and the immunoglobulins after cardiopulmonary bypass.


The isolated perfused rodent thymus as a source of lymphocytopoietic and immunocompetence promoting factors.


Glucagon in the pathogenesis of acute pancreatitis.


The response of the lower oesophageal sphincter to a meat-extract test meal.


The role of vagal release of gastrin in pancreatic enzyme secretion.


Lysolecithin: a factor in the pathogenesis of gastric ulceration?


Effect of secretin on pentagastrin-stimulated myoelectrical activity of the stomach.


Effect of renal revascularization by splenic artery implantation on experimental renovascular hypertension.


Contractility and compliance-elasticity studies in arterial vein autografts.


Prolonged left-heart by-pass without anticoagulation.


Soleal veins and local fibrinolytic activity.


Small doses of subcutaneous heparin preventing deep-vein thrombosis in major surgery.


Turbulence as a factor in the aetiology of varicose veins.


Bilateral traumatic renal artery occlusion with survival after late reconstitution of arterial flow.


Ruptured solitary cyst of the liver.

Ruptured solitary cyst of the liver.


Congenital oesophago-bronchial fistula in an adult.


Depersonalization syndromes.

Depersonalization syndromes.


Parents of psychotic children.

Parents of psychotic children.


General knowledge of cancer.

General knowledge of cancer.


Pollution in estuaries.

Pollution in estuaries.


Glucose tolerance and insulin secretion in patients with chronic duodenal ulcer. An oral glucose tolerance test has been used to compare carbohydrate metabolism in patients suffering from chronic duodenal ulceration with that in a matched group of normal subjects. A significantly greater rise in blood glucose concentration was observed in the duodenal ulcer group, and this was associated with a significantly greater output of insulin. The reason for these findings may be an abnormal secretion of one or more of the small-bowel hormones.


Hypertension and hyperparathyroidism.

Hypertension and hyperparathyroidism. Of 40 patients with primary hyperparathyroidism 13 were hypertensive. Nine presented with hypertension and, of these, seven were discovered to have hyperparathyroidism by the routine determination of serum calcium in 900 patients referred for investigation of hypertension. The association of hypertension and hyperparathyroidism is well recognized but the cause is in doubt. The incidence of primary hyperparathyroidism in patients with hypertension is about 1 in 130, which is considerably higher than in the general population (1 in 1,000-2,000). All patients with hypertension should have a routine serum calcium estimation. Parathyroidectomy in these otherwise asymptomatic cases may prevent renal damage.


Hypercalcaemia, hypophosphataemia, and inability to excrete hydrogen ions. Investigation of a patient with hypercalcaemia, hypophosphataemia, and nephrocalcinosis failed to lead to a clear diagnosis. Neither primary hyperparathyroidism nor primary incomplete renal tubular acidosis could explain all the biochemical features, and it seems that more than one fundamental abnormality may have been present.


Retroperitoneal haemorrhage simulating a strangulated inguinal hernia.


Localized clubbing and hypertrophic osteoarthropathy due to infection in an aortic prosthesis.


Progressive kidney damage after non-obstructive urinary tract infection.


Arthritis as an engineering problem: Leeds and London.


Radioactive bromide partition test in differential diagnosis of tuberculous meningitis. In 19 cases of lymphocytic meningitis, the radioactive bromide partition test showed that four were tuberculous and 15 viral in origin. In all the tuberculous cases the serum/cerebrospinal fluid bromide ratio was below a critical value of 1.6, and in all the cases of viral meningitis the ratio was above this value. The test may be particularly helpful when diagnosis is difficult. The test may prove to be a valuable and justified additional procedure in the early diagnosis of tuberculous meningitis.


Two psychiatrists and their views.

Two psychiatrists and their views.


Abortion deaths.

Abortion deaths.


Radiography of potentially pregnant females.


Drugs in infertility.

Drugs in infertility.


Consultants in mental handicap.

Consultants in mental handicap.


Active management of labour.

Active management of labour.


Graphic records in labour.

Graphic records in labour.


Vasectomy in the surgery.

Vasectomy in the surgery.


Canavan's disease and spongiform encephalopathy.


I.U.D. and uterine bleeding.

I.U.D. and uterine bleeding.


Australia antigen and pulmonary tuberculosis.


Gentamicin in urinary infections.

Gentamicin in urinary infections.


Serum and urine F.R.-antigen in renal disease.


Effect of ultrasound.

Effect of ultrasound.


Self-poisoning with paracetamol.

Self-poisoning with paracetamol.


How infectious is gonorrhea?

How infectious is gonorrhea?


Rubber cancer appeal.

Rubber cancer appeal.


The resistance to blood flow in the capillaries.


Failure of human growth hormone and human placental lactogen to affect glucose consumption by human erythrocytes and leucocytes in vitro.


Role of the gastric pacesetter potential defined by electrical pacing.


Comparative metabolism of  75 Se-selenite,  75 Se-selenate, and  75 Se-selenomethionine in bovine erythrocytes.


Relative importance of liver and kidney in synthesis of uric acid in chickens.


Effects of ethacrynic acid on vascular resistance, metabolism, and electrolyte flux in the canine gracilis muscle.


Relation between hydrogen ion secretion and oxygen consumption by ex vivo isolated canine stomach, perfused with homologous blood.


Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions.


Glucosinolates and their hydrolytic products in intestinal contents, feces, blood, and urine of rats dosed with rapeseed meals.


Estrogenic and anti-estrogenic effects of DDT administered in the diet to immature female rats.


Planning the University Hospital of Ophthalmology of Hamburg.


The planning of a 100-bed eye hospital.

The planning of a 100-bed eye hospital.


Clinical and academic work in a newly established eye hospital of 30 beds.


Experiences with modern departments of ophthalmology: University of Freiburg, Germany.


The use of examination units in eye hospitals.


Examination- and treatment-units in the out-patients department.


Modern examination units.

Modern examination units.


Organisation of the University Eye Clinic, Zürich.


The independently practising ophthalmologist as part-time associate in a university hospital.


Co-operation between the private oculist and the ophthalmologic clinic.


The medical engineer in the eye clinic.

The medical engineer in the eye clinic.


Co-operation as an instrument to achieve rationalization.


Co-operation between clinic and outside specialist.


Management of hospitals and medical centres.


Orientation about the building of the university eye hospital Würzburg.


Coding and indexing in ophthalmology.

Coding and indexing in ophthalmology.


Ophthalmology in the republic of China.

Ophthalmology in the republic of China.


Experiences with computer readable forms in the University Eye hospital, Würzburg.


Information processing in the hospital. The example of the Karolinska Hospital, Stockholm.


Plans for the development of electronic data processing in the Medical Faculty at Würzburg.


Development of the hospital. The staff of the university eye hospital, Würzburg.


First round-table. A. Mass screening for simple glaucoma. B. The differentiation between ocular hypertension and early glaucoma with normal fields.


Second round-table. Medical therapy of glaucoma.


The wards of the university eye hospital, Würzburg.


Out-patient department and orthoptic department of the university eye hospital, Würzburg.


Third round-table. Surgery of glaucoma.

Third round-table. Surgery of glaucoma.


The surgical department of the university eye hospital Würzburg.


Training of students and postgraduate, training in the university eye hospital Würgburg.


Services, administration, documentation.


The programme of the combined Eye, Ear-Nose-Throat, Neurology and Neurosurgery clinics, Würzburg with special reference to the Eye Clinic.


The eye hospital within the combined function of the head clinic.


Eye hospitals to-day and tomorrow. Wishes to change the original plans during and after building.


Eye hospitals to-day and tomorrow. Constructional adaptability to functional changes.


Eye hospitals to-day and tomorrow. Rationalization of the out-patient department.


Eye hospitals to-day and tomorrow. Ophthalmic surgical suite.


Eye hospitals to-day and tomorrow. Reconstruction of an out-dated clinical hospital.


The present state of eye clinics in Japan.


The new university eye clinic at Oulu, Finland.


The new eye hospital of Lucerne.

The new eye hospital of Lucerne.


Immediate drug detection on the spot.

Immediate drug detection on the spot.


The laboratory role in an epidemiologic approach to toxicological diagnosis.


A study of statistical techniques applied to changes during storage of serum specimens for multiphasic screening.


Tentative method of analysis for fluoride content of the atmosphere and plant tissues. G. Determination of fluoride (potentiometric method).


Tentative method of analysis for gaseous and particulate fluorides in the atmosphere (separation and collection with sodium bicarbonate coated glass tube and particulate filter) 42222-01-72T; 12202-03-72T.


Tentative method of analysis for gaseous and particulate fluorides in the atmosphere (separation and collection with a double paper tape sampler) 42222-02-72T; 12202-04-72T.


Tentative method of analysis for atmospheric soiling index by transmittance (paper tape sampler method) 11201-01-72T.


Tentative method of analysis for nitrate in atmospheric particulate matter (brucine method) 12306-02-72T.


Tentative method for calibration of continuous colorimetric analyzers for atmospheric nitrogen dioxide and oxide oxide 42602-02-72T; 42601-02-72T.


241. Geijerone (3-isopropenyl-4-methyl-4-vinylcyclohexanone), a new, naturally occurring C 12  terpenoid.


254. The solution conformation of cyclo-glycyl-L-prolyl-glycyl-glycyl-L-prolyl-glycyl. Communication 22 (preliminary) on homodetic cyclic polypeptides.


269. Steroid total synthesis. 8. (+)-Estr-4-ene-3, 17-dione.


271. Affinity chromatography with epsilon-aminocaproyl-choline derivatives.


Rendu-Osler-Weber disease: an unusual presentation.


Ocular changes in tuberculoid leprosy.

Ocular changes in tuberculoid leprosy.


New concepts in the epidemiology of scrub typhus.


Norwegian scabies (a clinical study).

Norwegian scabies (a clinical study).


Endemic goitre in the Narmada valley in Broach Districts, Gujarat.


Measles vaccination in a rural area.

Measles vaccination in a rural area.


Conversion of Vibrio cholerae and water vibrios into biotype el tor.


Dubin-Johnson syndrome: report of a case.


Diffuse malignant mesothelioma of the pleura.


Polycystic disease of kidneys and liver in twins.


Current techniques in cancer chemotherapy.


Effect of curcumin on blood sugar as seen in a diabetic subject.


Isolation and characterization of a thymic factor. A protein was isolated from bovine thymus that was shown to accelerate the appearance of hemolysin to sheep erythrocytes in neonatal mice. The isolation procedure consisted of saline homogenization, ammonium sulfate precipitation, and methanol precipitation, followed by chromatography on diethylaminoethyl-cellulose and two chromatographies on Sephadex G-150. The protein was shown to be homogeneous by polyacrylamide gel electrophoresis and by sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation. The molecular weight was determined to be 79,950. Additional physical and chemical characteristics were also determined.


Antiviral action of immune lymphocytes in mice infected with lymphocytic choriomeningitis virus. Spleen cells from immunized mice were shown to have a strong antiviral action after transfusion into infected recipients. Spleen, liver, and lung titers in recipients were reduced within 24 hr, but there was no detectable effect on brain titer. Spleen cells were active if taken 6 days after infection of donors, when no antibody was detectable. Spleen cell activity was diminished, but by no means abolished, by treatment with potent anti-theta antibody. Immune spleen cells transferred to mice infected 3 days earlier induced early signs of sickness but no change in average survival time. Normal mice injected intracerebrally with a mixture of immune spleen cells plus virus showed unusually early illness and death.


Stimulation of antibacterial vaccination in mice by polyadenylic acid: polyuridylic acid complex. The effect of polyadenylic acid:polyuridylic acid complex (poly A:U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 mug of poly A:U to vaccines rendered 3 x 10(8)B. melitensis cells in saline as immunogenic as 3 x 10(11) cells in oil adjuvant against a severe B. abortus challenge. In the mouse and Brucella system, poly A:U exerts an adjuvant effect on immunity but does not stimulate production of circulating antibodies that could be demonstrated at the time of autopsy.


Ecology of human oral lactobacilli.

Ecology of human oral lactobacilli. Lactobacilli were found in saliva, on teeth, and on the dorsum of the tongue, the vestibular mucosa, and the hard palate in humans. Their proportions in saliva, expressed as percentage of the anaerobically cultivable flora, were 10- to 100-fold higher than those on the tooth surface, but were comparable to those on the epithelial surfaces. The adherence of Lactobacillus casei and L. fermenti to oral surfaces was compared with that of streptomycin-labeled Streptococcus sanguis and S. salivarius by using in vitro-cultivated cells. The affinity of both Lactobacillus species for the tooth surface was very low compared with that of S. sanguis but was somewhat higher than that of S. salivarius. The lactobacilli and both Streptococcus species adhered to a similar extent to the dorsum of the tongue, whereas the affinity of the lactobacilli and S. salivarius for the vestibular mucosa was about one-half of that of S. sanguis. The results suggest that the affinity of lactobacilli for oral surfaces significantly influences their proportional distribution in the mouth. The relatively low affinity of lactobacilli for the tooth surface suggests that their recognized association with carious lesions and mechanical appliances under certain conditions may be due primarily to mechanical retention rather than unique growth conditions.


A role for activated macrophages in resistance to infection with Toxoplasma. Activated macrophages from mice which were chronically infected with Toxoplasma gondii or Besnoitia jellisoni, or which had received Freund complete adjuvant, had an enhanced capacity to to kill intracellular Toxoplasma. Enhanced killing by activated macrophages was demonstrated by decreased incorporation of isotopically labeled uridine by intracellular Toxoplasma and by inhibition of plaque formation. The latter resulted from lack of proliferation of the intracellular Toxoplasma which is normally followed by destruction of the host cell (macrophage) and secondary invasion and destruction of fibroblast monolayers.


Skin lesions produced by Staphylococcus aureus exfoliatin in hairless mice. Exfoliatin caused skin loss in hairless mutant mice only while they lacked hair, but older mice were more resistant to this effect than neonates.


The Swedish "experiment".

The Swedish "experiment".


Proportional distribution and relative adherence of Streptococcus miteor (mitis) on various surfaces in the human oral cavity. A group of streptococci possessing the characteristics of Streptococcus miteor (S. mitis) was found to predominate on nonkeratinized human oral mucosa. These organisms averaged from 76 to 89% of the total flora cultivable on anaerobically incubated blood agar plates from cheek, lip, and ventral tongue surfaces. They averaged 34, 40, and 18% of the streptococci in dental plaque, in saliva, and on the tongue dorsum, respectively. Their ability to adhere to oral surfaces was studied by introducing mixtures of streptomycin-resistant strains of S. miteor, S. salivarius, and S. mutans into the mouths of volunteers. Samples of oral surfaces taken 1 hr later indicated S. miteor adhered far better than the other streptococci to buccal mucosa and to teeth, but S. salivarius showed a higher affinity to the tongue dorsum. Glucose-grown cells of S. mutans adhered feebly to all oral surfaces studied and were rapidly cleared from the mouth. Cells of S. miteor and S. salivarius present naturally in saliva adhered to cleaned teeth comparable to in vitro cultivated strains. Electron microscopy of cells of S. miteor attached to buccal epithelial cells obtained from germfree rats indicated that the organisms possessed a fibrillar "fuzzy" coat which appeared to mediate their attachment to the epithelial cell membrane. This "fuzzy" coat was removed by treatment with trypsin, and it appears to be similar to that previously observed on cells of S. pyogenes and S. salivarius.


Naval pharmacist--Italian style.

Naval pharmacist--Italian style.


Determinants of international drug consumption.


U. S. pharmacy and European drug legislation.


MAP--international medical help.

MAP--international medical help.


The teaching of marketing related to the pharmaceutical industry's needs.


Morphology of the Achilles tendon in the newborn.


New enzyme aids phenol technique in nail surgery.


Tarsal tunnel syndrome: a case report.

Tarsal tunnel syndrome: a case report.


Suggested guidelines for the teaching of nitrous oxide-oxygen analgesia in podiatry at the continuing education level.


Laryngectomy: the influence of muscle reconstruction on the mechanism of oesophageal voice production.


Pollution effects on phycovirus and host algae ecology.


Biological removal of phosphates from water.


Bacteriophages recovered from septage.

Bacteriophages recovered from septage.


Cronkhite-Canada syndrome. Radiological and endoscopic features.


Experiments on influencing the serum bilirubin concentration by administration of diazepam to the newborn infant.


Clinico-pathological correlations in coronary artery disease.


Myocardial revascularization. Indirect approach by internal mammary artery implantation. Direct coronary artery surgery by the saphenous vein graft technique.


Surgery for complications of myocardial infarction.


Surgical techniques in infancy: hypothermia, bypass and postoperative care.


Factors affecting the development of pulmonary vascular obstructive disease.


Prosthetic valve follow-up: mechanical prosthesis.


Incidence and prevalence of ischaemic heart disease in Australia.


Homograft valves.

Homograft valves.


Aortic and mitral valve replacement with autologous fascia lata valves.


Comparative analysis of autologous, homologous and heterologous valves.


Current status of artificial heart development: assist and total replacement.


Cardiac pacing.

Cardiac pacing.


The natural history of coronary artery disease. Clinical correlations with arteriographic findings.


Crisis intervention. 1. A psychiatric community nurse in a rural area.


Hay fever. Discussion of an approach to more comprehensive treatment.


Nutrition labeling.

Nutrition labeling.


Percutaneous common-duct stone extraction.


The effect of atmospheric sulfur dioxide on croup syndrome. Computer analysis.


The physical development of children with cystic fibrosis.


On the clinical diagnosis and assessment of angina pectoris.


Effect of intravenous salicylates on the gastric mucosal barrier in man.


Intestinal microflora and absorption in patients with stagnation-inducing lesions of the small intestine.


Electric and motor activity of innervated and vagally denervated feline esophagus.


The relationship between granulomatous bowel disease and duodenal ulcer.


Bile salt and lipid metabolism in patients with ileal disease with and without steatorrhea.


Agenesis of gallbladder with common duct stones.


Advances in neurosurgery for the spinal cord injured--from past to present.


Dermatoglyphics in a small sample of Italian males. Mostly with paranoid schizophrenia.


Compatibility of zinc oxide shake lotion with containers.


Group counseling with institutionalized delinquent females.


Gastric acid secretory activity of iron-deficient rats.


Volume control sets, minibottles and minibags.


Comparison of physical fitness scores of high school girl smokers and nonsmokers.


Voluntarism as a dynamic facet in the administration of rehabilitation.


Need for a uniform hospital pharmacy management data system.


Deficiencies of the task force criteria for identifying subprofessional tasks.


Amino acid stability in aqueous solutions of casein hydrolysate under varied storage conditions.


Pharmacy audit of patient health records--feasibility and usefulness of a drug surveillance system.


The role of a pharmacist on the pediatric unit of a general hospital.


Women pharmacists in hospital and community practice.


A computerized drug inventory control system.


Problems encountered by pharmacy students conducting patient interviews.


Cerebral blood flow, oxygen consumption, and glucose utilization of fetal lambs in utero.


Adrenal gland and sympathetic nervous system response in eclampsia.


Cultivated epithelial-like cells and fibroblasts from amniotic fluid: their relationship to enzymatic and cytologic analysis.


Gallium-67 scintigraphy of gynecologic tumors.


Oviductal sterilization with tantalum clips.


The effect of prostaglandin F2 alpha infusion on corpus luteum function. The effect of prostaglandin (PG) F2 alpha on corpus luteum function in normal women with regular menstrual cycles was investigated.  21 women were recruited as volunteers and PGF2 alpha was infused for 8 hours (25 mgm).  Infusions were given between Day 14 and 27 of the luteal phase of the cycle, with Day 14 arbitrarily considered the time of ovulation.  13 of 21 women showed a shortened luteal phase of at least 1 day or less.  1 of 2 women, given PGF2 alpha before ovulation, failed to ovulate, and 2 other patients had anovulatory cycles in the immediate postinfusion cycle.  Steroid parameters (serum progesterone, urinary pregnanediol, and serum estradiol) failed to show a consistent change.  Measurements of serum progesterone and estradiol during infusion showed an initial depression and subsequent elevation of steroid levels measured.  It is concluded that an 8-hour infusion of PGF2 alpha in women fails to disrupt corpus luteum function.


A composite picture of the menstrual cycle.


A controversy in fetal ecology.

A controversy in fetal ecology.


An automated method for the determination of lead in calcareous materials utilising liquid ion exchange.


Transient rheoangiographic changes in the forearms in attacks of anginal pain.


The trapped endocardial electrode. Removal by prolonged graded skin traction.


Effect of external lymph drainage and of coumarin treatment on dextran edema.


Surgical repair of coarctation of the aorta by patch grafting.


Current indications for and status of decortication for "trapped lung".


Penetrating chest injuries in children.

Penetrating chest injuries in children.


Surgical management of myasthenia gravis.


Congenital cystic lesions of the bronchi and lungs.


Dilatation for severe esophageal stricture.


Ventilation during bronchofiberscopy.

Ventilation during bronchofiberscopy.


Improved oxygenation during bronchoscopy.


The flexible fiberoptic bronchoscope.

The flexible fiberoptic bronchoscope.


Hand, foot and mouth disease. Light and electron microscopic observations.


Proteolytic enzymes in washing powder--their effects on the esterase-mantle, lipids, proteins, and pH on the skin surface.


Time-limited desensitisation, implosion and shaping for phobic patients: a crossover study.


Modelling therapy for test anxiety: the role of model affect and consequences.


The role of mental relaxation in experimental desensitization.


Theoretical problems of aversion therapy.


Using drugs to modify the effect of response prevention on avoidance extinction.


Writer's cramp: a behavioural approach.

Writer's cramp: a behavioural approach.


Psychophysiological responses during analogue systematic desensitization and non-relaxation control procedures.


Stuttering, neuroticism and extraversion.


Eliminating versus reducing smoking using pocket timers.


A behavioural-pharmacological treatment of dually addicted patients.


Vicarious desensitization of test anxiety.


The contribution of therapeutic instruction of covert sensitization.


Nonresponsiveness of patients to token economies.


Overlearning in the conditioning treatment of enuresis: a long-term follow-up study.


The liver as a source of extrarenal erythropoietin production.


Freedom of the medical press.

Freedom of the medical press.


ABO blood groups and abortion.

ABO blood groups and abortion.


A common goal?

A common goal?


Mixed connective tissue disease.

Mixed connective tissue disease.


Renal radiology.

Renal radiology.


Pertussis in adults.

Pertussis in adults.


Perinatal coagulopathies complicating fetal blood sampling. In a neonatal postmortem histological study of scalp stabs made with a fetal blood sampling blade the aponeurosis was punctured in up to 38% of cases even when it was more than 2 mm deep. This and other indirect and direct evidence discussed suggest that five of the seven reported cases of major bleeding after fetal blood sampling in labour were due to blood clotting defects and that these should be considered urgently in the management of future cases.


Massive scalp haemorrhage after fetal blood sampling due to haemorrhagic disease. Massive subaponeurotic haematoma occurred in a baby after suture of bleeding scalp blood sampling stabs made before delivery. Eighteen hours after delivery blood samples showed marked prolongation of the prothrombin time. The condition was successfully treated with vitamin K(1) and blood transfusion.


Changes in human drug metabolism after long-term exposure to hypnotics. The influence of the newer, non-barbiturate hypnotics Mandrax (diphenhydramine-methaqualone) and nitrazepam on drug-metabolizing capacity was assessed and compared with the effect of amylobarbitone, a known inducer of drug-metabolizing enzymes. Plasma antipyrine and phenylbutazone half-lives and urinary output of 6beta-hydroxycortisol were used as indices. Volunteer subjects were exposed to therapeutic amounts of these agents and, in the case of Mandrax and barbiturates, further studies were carried out in dependent patients.Mandrax but not nitrazepam increased the rate of drug metabolism, presumably by enzyme induction. The degree of induction was comparable with that produced by hypnotic doses of amylobarbitone. The Mandrax-dependent and barbiturate-dependent patients were the fastest metabolizers studied. It is concluded that drug interactions resulting from interference with drug metabolism are as likely to occur with Mandrax as with barbiturates. On the other hand, it is unlikely that such drug interactions would occur with nitrazepam.


Secretion of dopa in phaeochromocytoma.

Secretion of dopa in phaeochromocytoma. In a series of 11 cases with phaeochromocytoma, two patients were found in whom the tumour secreted dopa in addition to dopamine, noradrenaline, and adrenaline. These two patients were normotensive in spite of high plasma and urinary levels of noradrenaline and adrenaline. This raises the possibility that dopa may be able to protect against the hypertensive action of noradrenaline. Such a mechanism would also explain the absence of hypertension in many cases of neuroblastoma.


Acute zinc toxicity in haemodialysis.

Acute zinc toxicity in haemodialysis. A country patient on home haemodialysis suffered acute nausea, vomiting, and fever during dialyses when she used water stored in a galvanized tank. She subsequently was found to have severe anaemia with raised plasma and erythrocyte zinc concentrations. Intercurrent hospital haemodialyses and subsequent home dialyses with deionized water were symptom-free.Experimental haemodialyses of dogs against small concentrations of zinc showed a disproportionate rise in plasma zinc and possible uptake of zinc by the liver.


Impressions of cogwheel. General practitioner.


Plasma steroid and luteinizing hormone levels during prostaglandin F 2   administration in luteal phase of menstrual cycle. An intravenous infusion of prostaglandin F(2)alpha (12.5-250mug/min) was administered in four volunteers in the mid-late luteal phase and three in the early luteal phase of the menstrual cycle.Frequent measurement of plasma progesterone, oestrogens, and luteinizing hormone (LH) showed that administration of high doses depressed plasma progesterone levels in the late luteal phase and caused concomitant side effects. Levels of progesterone in the early luteal phase were unaffected. In both phases oestrogen and LH levels were little altered. In two subjects, hourly progesterone levels measured throughout the day at a similar time in a subsequent control menstrual cycle showed an appreciable variation in one but steady levels in the second. This variation may contribute to the magnitude of the fall in progesterone noted during the infusion of prostaglandins.


Prostaglandins.

Prostaglandins.


Tests on the pill for carcinogenicity.

Tests on the pill for carcinogenicity.


Foreign exchange visits.

Foreign exchange visits.


Renal failure in acute pancreatitis.

Renal failure in acute pancreatitis.


Duodenal reflux and pyloric surgery.

Duodenal reflux and pyloric surgery.


Chlamydia in chronic prostatitis.

Chlamydia in chronic prostatitis.


Diagnosis of renal agenesis.

Diagnosis of renal agenesis.


Immunological responses in pregnancy.

Immunological responses in pregnancy.


Gas gangrene and hyperbaric oxygen.

Gas gangrene and hyperbaric oxygen.


Uganda Asians.

Uganda Asians.


Luteinizing hormone and progesterone levels after hysterectomy.


Estimating fibrin products in urine.

Estimating fibrin products in urine.


Heart failure and neonatal hypocalcaemia.


Multiple factors in leukaemogenesis.

Multiple factors in leukaemogenesis.


Gastric acid secretion in chronic renal failure.


Late onset psychoses.

Late onset psychoses.


Future of child guidance clinics.

Future of child guidance clinics.


Lead poisoning.

Lead poisoning.


Bone disease in chronic renal failure.

Bone disease in chronic renal failure.


Fat atrophy due to insulin.

Fat atrophy due to insulin.


Middle class syndrome.

Middle class syndrome.


Candidates for coronaries.

Candidates for coronaries.


Uptake of gallium-67 in malignant tumours.


End of dentist's libel action. Some legal implications of the Drummond-Jackson action.


Clinical assistants in anaesthetics.

Clinical assistants in anaesthetics.


Monitoring of the cerebral circulation and cerebrospinal fluid chemistry in the management of head injury.


Lung function following trauma in man.

Lung function following trauma in man.


Mechanisms of injury in automobile crashes.


Interaction of the driver, the vehicle, and the road.


Prognosis after severe head injury.

Prognosis after severe head injury.


The neurosurgeon's responsibility in the prevention of sports injuries.


Diagnostic concepts of cerebral injuries.


Medical management of closed head injuries.


Surgical management of head injuries in children in the acute phase.


Cerebrospinal fluid rhinorrhea and otorrhea.


Management of post-traumatic subdural hematoma in infancy.


Recognition and treatment of metabolic disorders after head injuries.


The management of acute midfacial-orbital injuries.


Blood vessel trauma following head and neck injuries.


The diagnosis and treatment of auditory and vestibular disorders after head injury.


Presidential address.

Presidential address.


Prevention and mitigation of injuries.

Prevention and mitigation of injuries.


Disorders of learning and memory after temporal lobe lesions in man.


The pathophysiology of the cerebral circulation in head injury.


The natural history of primary and secondary liver tumours. V. The prognosis for conventionally treated patients with liver metastases.


Mental health service quality control: an idea whose time has come.


The myth of suicide prevention.

The myth of suicide prevention.


The many effects of lactulose: a rational approach to its therapeutic use.


Target symptoms in lithium carbonate therapy.


Chlordiazepoxide plasma levels and clinical responses.


Management of haemorrhoids and associated ano-rectal conditions.


Interactions of lactulose and neomycin.

Interactions of lactulose and neomycin.


Homosexuality in the United States Air Force.


Psoriasis: its nature and treatment.

Psoriasis: its nature and treatment.


A survey of psychiatric opinion on schizophrenia.


Depression as a model for behavioral analysis.


Ultrastructural changes in hepatocytes induced by pregnenolone-16 -carbonitrile (PCN).


Vascularization of developing anterior lamb of the chick embryo. II. Differentiation of vascular bed and its significance for the location of morphogenetic processes inside the limb bud.


Vascularization of the developing anterior limb of the chick embryo. 3. Developmental changes in the perimetacarpal capillary network.


The ultrastructure of the tracheal epithelium in rabbits following the inhalation of aerosols of colloidal solutions of heavy metals. 3. A contribution to the study of the regneration of the tracheal epithelium.


Postpsychotic depression in schizophrenics.


Schizophrenia and despair.

Schizophrenia and despair.


Ischaemic heart disease in maturity onset diabetes--clinical profiles.


Single coronary artery.

Single coronary artery.


Persistent left superior vena cava.

Persistent left superior vena cava.


A preliminary report on a clinical trial of peruvoside--a new cardiac glycoside.


Haemo-pneumo-pericardium.

Haemo-pneumo-pericardium.


Diagnostic puzzle: interesting electrocardiogram.


Horizons of cardio- vascular health.

Horizons of cardio- vascular health.


Is heart disease on the increase in India?


Early recognition of ischaemic heart disease.


Heart disease in the world: prospects for prevention.


Acute cardiac infarction treated in an intensive coronary care unit.


Mycoplasma pneumoniae vaccine: antigenicity of buffered antigens in volunteers. The antigenicity of experimental Mycoplasma pneumoniae vaccines prepared from antigen grown in a medium buffered with N-2-hydroxyethylpiperazine-N'-2'-ethanesulfonic acid was tested in young, adult males. Formalin-inactivated antigens from a high-passage strain and a low-passage strain at various dilutions (12 to 123 mug of N/ml) were injected intramuscularly in 1-ml doses. Antibody responses were tested by the metabolic inhibition (MI) technique. Sixty-five to 86% of the volunteers in all vaccine groups responded with fourfold or greater MI antibody rises, but only nine (39%) of 23 antibody-free subjects converted compared to 53 (88%) of 60 of those with pre-existing antibody. A booster vaccination did not increase the number of converters or enhance the geometric mean titers. The antigen concentrations of vaccines with 24 or more mug of N/ml appeared to be above the threshold needed for maximal antibody responses in the dose range tested. MI antibody rises could not be detected in sputa and nasal washings obtained from a small group of vaccinees. The results of this study suggest that the new vaccines offer little or no improvement in antigenicity in man over earlier inactivated vaccines.


Experimental studies on cholera immunization. II. Evidence for protective antitoxic immunity mediated by serum antibodies as well as local antibodies. By use of the ileal loop technique, the resistance to challenge with cholera enterotoxin was compared between unimmunized rabbits and rabbits immunized with toxin or toxoids. It was shown that subcutaneous as well as intraintestinal immunization induced protective immunity, the toxin being a better immunogen than Formalin-induced toxoid and much better than heat-induced toxoid. The relation between protection and serum antitoxin titer was poor, e.g., protection was seen in the absence of demonstrable serum antibodies. However, intravenous administration of antitoxic antiserum conferred some protection, suggesting that local as well as serum-mediated antitoxic immunity is operating in the host defence against cholera.


Experimental infection of horses with an attenuated Venezuelan equine encephalomyelitis vaccine (strain TC-83). Ten horses (Equus caballus) were vaccinated with strain TC-83 Venezuelan equine encephalomyelitis (VEE) virus vaccine. Febrile responses and leukopenia due to a reduction of lymphocytes and neutrophils were observed in all animals. Viremias were demonstrable in eight horses, with a maximum of 10(3.5) median tissue culture infectious dose units per ml of serum in two horses. Clinical illness with depression and anorexia were observed in five horses. Neutralizing (N), hemagglutination-inhibiting, and complement-fixing antibodies to the vaccine virus were demonstrable by 5, 6.5, and 7 days, respectively, after vaccination. Differential titrations of serum to six VEE strains revealed high titers of N antibody to vaccine virus, moderate titers to the epizootic Trinidad donkey no. 1 strain (VEE antigenic subtype I, variant A) from which TC-83 was derived, and low titers to two other epizootic strains (subtype I, variants B and C) in all horses at 1 month after vaccination; some animals responded with low levels of N antibody to the enzootic viruses (subtype I, variants D and E). Fourteen months after vaccination, six animals with detectable N antibody were challenged with MF-8 (subtype I, variant B), an epidemic-epizootic strain isolated in 1969 from a man in Honduras. All horses resisted challenge with the equine pathogenic strain of VEE. Marked increases of N antibody in most horses were demonstrable to some VEE strains when tested 1 month after challenge.


Experimental paracoccidioidomycosis in mice. Virulence and infectivity of nine strains of Paracoccidioides brasiliensis were investigated in groups of mice which were inoculated intranasally or intravenously, and some of each were treated with corticosteroids. Fatal infections were not often seen among untreated mice, but mortality usually occurred when corticosteroids were given, regardless of the route of fungus inoculation. Prior treatment did not uniformly increase the incidence of infection, however; only in the case of intranasally inoculated mice was this effect seen. Most strains appeared to be more virulent when administered intravenously, with the exception of a single strain which, under the influence of corticosteroids, repeatedly displayed greatest virulence when given intranasally. All animals that died early in the course of the disease, irrespective of route of inoculation, always had acute pulmonary lesions and usually no other organ was involved. Animals which died later or were sacrificed always had chronic lung lesions. Whether or not chronically diseased animals had additional organ involvement correlated with how the organisms were administered; intravenously inoculated animals usually had extrapulmonary as well as pulmonary lesions, but lesions of those inoculated intranasally were almost exclusively pulmonary. Corticosteroids did not alter the histologic characteristics of either the acute or the chronic type of lesion, but the lesions of treated animals were usually more extensive. Most of the survivors appeared healthy even when infection was extensive.


Staphylococcidal capability of rabbit peritoneal macrophages in relation to infection and elicitation: induction and elicitation of activated macrophages. The capability of macrophages to inactivate ingested staphylococci can be augmented when repeated infection is followed by specific elicitation with staphylococcal lysate. The increase in staphylococcidal capability with specific elicitation after infection is not dramatic but is statistically significant. The percentage of change in staphylococcidal capability after infection and specific elicitation is systematically related to the staphylococcidal capability of the populations of macrophages in the same rabbits studied prior to infection. When the capability of the initial populations of macrophages has been high, the percentage of change after infection and elicitation may be slight or even negative. When the staphylococcidal capability of the initial population of macrophages in a given rabbit has been low, there is typically a significant increase in this capability after infection and elicitation. It is shown at the cellular level that it is possible to evoke a population of activated macrophages, by a procedure which is analogous to procedures reported as useful in human practice.


Staphylococcidal capability of rabbit peritoneal macrophages in relation to infection and elicitation: delayed-type hypersensitivity without increased resistance. The staphylococcidal capability of populations of peritoneal macrophages in rabbits has been measured before and after repeated infections with Staphylococcus aureus. Such rabbits after infection showed delayed-type hypersensitivity to S. aureus antigens, but the staphylococcidal capability of the peritoneal macrophages was not increased. This result at the cellular level is in agreement with previous assessment in vivo of the consequences of staphylococcal infection. Pathways to cell-mediated resistance, with and without delayed-type hypersensitivity, are presented.


Effects of purified staphylococcal alpha toxin on the ultrastructure of human and rabbit erythrocytes. Previous studies have suggested that the primary site of action of purified staphylococcal alpha toxin is the cell membrane. Scanning and transmission electron microscopy studies were undertaken, therefore, to define toxin-induced alterations in the surface morphology of rabbit and human red blood cells. During the prelytic lag phase, scanning electron microscopy revealed multiple discrete blisters on the surface of rabbit red blood cells; during hemolysis, cellular collapse and ghosts were seen, but most striking was the separation of large fragments of cell membrane from red blood cell surfaces. In contrast, alterations in less sensitive human red blood cells were limited to occasional fingerlike protrusions during the period of accelerated lysis. Transmission electron microscopy substantiated these changes. These studies have provided further evidence that the cell membrane is the primary site of action of staphylococcal alpha toxin.


Responses of lymphocytic choriomeningitis carrier mice to X-ray-induced lymphoma. The data presented in this paper define the interrelationship between two endogenous diseases in the same host. The Haas strain of germfree mice with congenitally acquired persistent lymphocytic choriomeningitis (LCM) virus infection developed the X-ray-induced lymphatic leukemia independent of LCM viremia. The immunoproliferative LCM-related lesions appeared after age 7 months, and the radiogenic lymphatic leukemia appeared earlier or during the same age period. Both diseases evolved with distinctive lesions at the appropriate time, with no evidence of interference nor of synergism between the two syndromes. The Haas strain of mice showed an unusual sensitivity to X rays which was associated with depletion of blood components and coincident death. The sensitivity of the mice to X rays might be a characteristic of the Haas mouse or the result of an LCM virus-induced alteration in hematopoiesis.


Stimulation of rabies vaccine in mice by low doses of polyadenylic:polyuridylic complex. Addition of 100 mug of polyadenylic: polyuridylic (poly A:U) complex to each dose of inactivated rabies vaccine increased immunity to rabies challenge in mice. Stimulation was also observed after addition of 10 mug of poly A:U to the vaccines. Mixtures of rabies vaccine and poly A:U lost their stimulatory properties after storage at 37 or 4 C for 1 month. However, these data are encouraging for practical use of poly A:U as an adjuvant to viral vaccines.


Transplacental transmission of Venezuelan equine encephalomyelitis virus in mice. Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 10(3) suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to mating to 9 days after conception, had no effect on conception rate, litter size, or survival of the newborn. Inoculation of the dam from the 10th to 13th days of gestation resulted in decreased litter size, an increase in stillbirths, and a decrease in birth-to-weaning survival. Inoculation of the dams later in gestation only decreased the birth-to-weaning survival. No evidence of morphologic abnormality was noted in any of the newborn.


Protective action of 2,2-bis(parachlorophenyl). 1,1,1-trichloroethane against intoxication of cells by staphylococcal enterotoxin B. Chlorinated hydrocarbon 2,2-bis(parachlorophenyl)-1,1,1-trichloroethane (DDT) and its derivative 2,2-bis(parachlorophenyl)-1,1-dichloroethane (o,p'-DDD) protected the cells of human embryonic intestine, Henle strain, against the cytotoxic effects induced by staphylococcal enterotoxin B (SEB). The hydrocarbons were incorporated in the culture medium, and the cytotoxicity of SEB was measured by cell destruction and by inhibition of cell growth during incubation for 48 hr. When DDT at nontoxic levels (4 to 25 mug/ml) was added to cultures, 24 or 4 hr prior to or 7 hr after the administration of toxin (100 mug/ml), the cells did not show the characteristic cytotoxicity. A therapeutic effect was also observed with o,p'-DDD added to cultures 9 hr after SEB. Because the cells treated with DDT for a period of 24 hr remained resistant to the toxin when DDT was removed from the cultures, it appears that DDT acts upon the cells rather then upon enterotoxin B. The protective effect of DDT was also observed against the toxin-induced skin erythemas and necrosis in guinea pigs treated with DDT.


Purification of polysaccharide antigen from Leptospira biflexa strain Urawa. Serologically active polysaccharide was isolated from the cells of Leptospira biflexa strain Urawa and purified. The constituents of this polysaccharide were characterized, and its serological specificity was partially examined.


Heterogeneity of Streptococcus mutans strains based on their mannitol-1-phosphate dehydrogenases: criterion for rapid classification. Hexitol phosphate dehydrogenases were inducible in all strains of Streptococcus mutans studied, and these organisms could be placed into one of four groups according to the electrophoretic mobility of their mannitol-1-phosphate dehydrogenases.


Inhibition of protein synthesis after intravenous or intramuscular challenge with diphtheria toxin. Inhibition of protein synthesis in guinea pig tissues after administration of diphtheria toxin varies significantly with the route of injection.


Review of 200 psychiatric patients referred for rehabilitation.


Three years' experience of myocardial infarction.


Detection of Australia antigen by a latex agglutination test.


Management of cardiac dysrhythmias: a summary of current practice.


Congenital abnormalities.

Congenital abnormalities.


Hypertension and cerebrovascular disease.


Management of severe hypertension.

Management of severe hypertension.


Hypertension--a community problem.

Hypertension--a community problem.


Hypertension: who to investigate and treat.


Mechanism of thermopositive behavior in larval hookworms.


Strength-duration curves in cardiac Purkinje fibres: effects of liminal length and charge distribution. 1. Strength-duration curves for excitation in long point-stimulated sheep cardiac Purkinje fibres, where the charge distribution varies along the length of the fibre, are characterized by (a) a time constant which is short relative to the membrane time constant, (b) an apparent fall in charge threshold for short duration stimuli, (c) an apparent rise in voltage threshold as measured by an electrode at the point of current passage (see Dominguez & Fozzard, 1970).2. Strength-duration curves obtained from shortened segments of Purkinje fibres, where the charge distribution along the segment is fairly uniform after 2-3 msec, have much larger time constants.3. For stimulus durations longer than the 2-3 msec necessary to establish charge uniformity, strength-duration curves obtained from shortened segments of Purkinje fibres were well fitted by the Lapicque-Hill equation, I/I(rh) = [1 - exp (-t/tau)](-1).4. The differences in the time constants and apparent voltage thresholds for point-stimulated long fibres and uniformly charged short fibre segments could be explained by the liminal length concept of Rushton (1937). The liminal length concept, in its simplest form, states that a liminal length of fibre must be raised above a given voltage threshold in order for a propagated action potential to be generated.5. This concept predicts that the shorter the liminal length, the shorter the time constant of strength-duration curves in point-stimulated long fibres.6. Another conclusion of the model is that only those point-stimulated long fibres with longer liminal lengths would have a constant charge threshold for stimuli of the order of 0.2 tau.7. Liminal length was found by experiment and calculation to be about 0.1-0.2 lambda(m) in cardiac Purkinje fibres.8. The differences in behaviour with regards to excitation between the point-stimulated theoretical squid axon and the point-stimulated Purkinje fibre may be explained by assuming that the liminal length of the theoretical squid axon is several times larger than that of the Purkinje fibre.


Further evidence for a potassium-like action of lithium ions on sodium efflux in frog skeletal muscle. 1. The efflux of labelled sodium as well as net sodium and lithium changes were studied in aged high sodium sartorius muscles of the South American frog Leptodactilus ocelatus.2. In the presence of 2.5 mM potassium in the media, the replacement of external sodium with lithium or magnesium resulted in an increase in sodium efflux. The magnitude of such increase was always larger in lithium.3. With the absence of potassium in the media, the response of sodium efflux to replacement of external sodium varied with the cation used as a substitute. In lithium Ringer there was always a noticeable increase, whereas in magnesium there was always a marked reduction. The same results were observed when calcium was substituted for magnesium.4. The replacement of 60 mM external sodium with sucrose did not prevent the stimulating effect of 5 mM potassium on sodium efflux, nor the inhibitory action of 10(-4)M ouabain. This indicates that neither sucrose by itself, nor the lowering of the ionic strength, modified to an appreciable extent the function of the sodium pump.5. Net sodium extrusion took place against an electrochemical gradient in potassium-free - 50 mM sodium - mM lithium Ringer. About 75% of this efflux was ouabain sensitive.6. Muscles made both sodium and lithium rich and incubated in potassium-free - 60 mM sodium - 50 mM lithium Ringer also showed net sodium extrusion against an electrochemical gradient, which was 85% ouabain sensitive. This extrusion took place even under conditions where the changes in free energy favouring lithium entry were always lower than the changes in free energy opposing sodium going out. This indicates that a sodium-lithium exchange by a counter-transport process is unlikely.7. External potassium reduced the ouabain sensitive lithium influx in muscles incubated in lithium Ringer. The values found were 5.90 +/- 0.39 mu-mole/g.hr and 2.66 +/- 0.43 mumole/g.hr in potassium-free and 15 mM potassium respectively. At the same time potassium had no effect on the ouabain-insensitive lithium uptake.8. Muscles incubated in potassium-free-magnesium Ringer had a residual sodium efflux which could not be accounted for by passive movement. About 40% of it was abolished by 10(-4)M ouabain. This ouabain-sensitive part could be a consequence of some stimulation of the sodium pump by potassium leaking out of the cells. If this is correct it should be inhibited by external sodium and should not contribute to the total sodium efflux in potassium-free sodium media.9. Magnesium was used as the reference cation to study the sodium-stimulated sodium efflux under potassium-free conditions. The total sodium efflux amounted to 0.668 hr(-1) (rate constant) and was 71% ouabain sensitive.10. The present experiments demonstrated that lithium ions have a direct stimulating effect on sodium efflux in high sodium skeletal muscle, and strongly support the notion that this effect is produced by an activation of the sodium pump through a potassium-like action.


After-images on backgrounds of different luminance: a new phenomenon and a hypothesis. 1. After-images may be caused to vanish suddenly and reversibly by viewing them against a background of suitable luminance I(e).2. The value of I(e) at any moment is not related to any parameter (intensity, colour, duration, time) describing the stimulus that caused the after-image.3. On the other hand, I(e) is very closely related to the immediate adaptational history of the eye, so that viewing a dark background for a few seconds lowers, and a light one raises, the value of I(e).4. It is suggested that the signal conveying sensations of relative brightness in this situation is related to the rate of change of concentration of an intermediate photo-product decaying spontaneously with a time constant of some 14 sec.


Calcium dependence of ciliary activity in the oviduct of the salamander Necturus. 1. Ciliary activity in the oviduct of the mud puppy Necturus maculosus was monitored by a photometric technique in normal, decalcified, and Triton X-extracted preparations to investigate the regulatory role of calcium ions.2. The frequency of ciliary beating in the isolated tissue ranged from 0 to 12 beats/sec. The frequency in any one group of cells underwent large cyclical variations with periods of 2 min or more.3. Frequency of beating reached a maximum and remained at a plateau upon addition of 1 mM caffeine. Beating temporarily ceased upon removal of the caffeine.4. Ionophoretic injection of calcium ions into an active cell bathed in Ringer solution produced an increased rate of beating. In cells rendered quiescent by prior decalcification with EGTA, injected calcium rapidly restored ciliary activity.5. Epithelia extracted in Triton X-100 were inactive until reactivated by addition of ATP and magnesium ions. The frequency of beating increased between 0.1 and 4.0 mM ATP in 1 mM magnesium, and between 0.2 and 2.5 mM magnesium in 1 mM ATP.6. The frequency of beating in the ATP-reactivated, Triton-extracted tissue was independent of the calcium ion concentration.7. Cells inactivated by decalcification were reactivated by injection of ATP or by extracellular ATP levels as low as 3 x 10(-8)M.8. It is concluded that the frequency of beating depends directly on the concentration of the available energy source, presumably ATP, and that an indirect dependence of beating frequency on calcium concentration in the living tissue results from rate-limiting effects of intracellular calcium on metabolic steps in pathways leading to ATP synthesis.


Properties and distribution of peripherally evoked presynaptic hyperpolarization in cat lumbar spinal cord. 1. The action of peripheral nerve volleys on the polarization of presynaptic terminals of inactive sensory fibres in cat lumbar spinal cord has been investigated by recording (a) the dorsal root potential (DRP), (b) intracellular changes in polarization of single preterminal axons (PAD or PAH), and (c) changes in excitability of populations of preterminal axons.2. Presynaptic hyperpolarization (positive DRP-PAH) can be evoked by stimulation of muscle group III afferents as well as by volleys in cutaneous Abeta, Adelta and C afferents. These volleys can also produce presynaptic depolarization (negative DRP-PAD).3. The positive DRP is observed in the decerebrate state and increases in amplitude following spinalization.4. Picrotoxin blocks the positive DRP at the same dosages required to block the negative DRP. Test negative DRPs are depressed during a conditioning positive DRP. These results are used to support earlier suggestions that the positive DRP results from inhibition of interneurones mediating the negative DRP.5. Trains of group III stimuli at 20/sec evoke a steady positive DRP. Trains of the same intensity at 200/sec evoke a phasic negative DRP. This frequency dependence is observed for PAD and PAH in single sensory axons.6. The DRPs recorded from different dorsal root filaments in response to a given stimulus vary widely in the ratio of negative to positive DRP.7. Intracellular recording from single axons reveals that the same stimuli evoke widely varying ratios of PAD and PAH.8. Stimulation of FRA evokes PAH > PAD in PBST group I afferents, PAD > PAH in sural A fibres and intermediate effects in G-S group I units.9. It is suggested that activation of flexor reflex afferents may selectively potentiate the synaptic efficacy of large muscle afferents mediating the flexor reflex rather than large skin afferents or large afferents from extensor muscles.


The effects of decerebration on the reflex response to pulmonary vein distension. 1. A method is described for the decerebration of dogs using high frequency coagulation. Animals made decerebrate by this method showed a slowing of the heart rate and a decrease in arterial pressure.2. Distension of the pulmonary vein-left atrial junctions by the inflation of small balloons caused an increase in heart rate in intact and decerebrate dogs. The magnitude of the response was not significantly different in the two states.3. The increase in heart rate caused by pulmonary vein distension was shown to be a reflex. It was significantly reduced by injection of propranolol both before and after decerebration. Cervical vagotomy always prevented any response.4. The similarity of the responses before and after decerebration suggests that structures rostral to the superior colliculus are not required for the appearance of the full reflex effect.5. The magnitude of the response remaining after administration of propranolol raised the question of the efficacy of propranolol as a beta-blocking agent in this experimental situation, or alternatively suggests the possibility of the existence of an efferent vagal component to the reflex response.


Coyote reproduction. I. The duration of the spermatogenic cycle and epididymal sperm transport.


Factors forming the edge of a receptive field: the presence of relatively ineffective afferent terminals. A specialized type of spinal cord cell has its cell body in lamina IV and has a small low threshold cutaneous receptive field which is remarkable for its abrupt edge. No signs could be found of a subliminal fringe to this field since its size remains fixed during wide excursions of the cell's excitability. Reversible blocking of peripheral nerves and dorsal roots showed that the afferents responsible for exciting these cells following natural stimuli, run in a restricted area of peripheral nerve and dorsal root. When the fibres necessary to sustain the natural stimulus receptive field were blocked, it was shown that other large myelinated fibres in neighbouring roots were still capable of firing the cell monosynaptically following electrical stimulation of the root or periphery although no natural stimuli were able to change the cell's excitability. It is necessary to divide the afferent synapses on such cells into a class which is highly effective in firing the cell on natural stimulation and a second class which has no effect yet detected following natural stimuli but which can fire the cell monosynaptically if synchronously activated by electrical stimulation. Suggestions are made for possible presynaptic and post-synaptic mechanisms which might divide the effect of arriving impulses into two such classes.


Histological and functional analysis of the autotransplanted corpus luteum of pregnancy in the rat.


Maintenance of corpora lutea and pregnancy in unilaterally pregnant gilts by intrauterine infusion of embryonic tissue.


Non-surgical recovery of equine eggs, and an attempt at non-surgical egg transfer in horses.


The effect of factors associated with the male on numbers of ovulations, uterine weight and pituitary LH content in the rat.


The effect of prostaglandin E on rabbit sperm transport in vivo.


Purification of aspermatogenic substance in bull seminal vesicle fluid.


Shedding of the zona pellucida of the mouse blastocyst in normal pregnancy.


Implantation in lactating rats treated with insulin.


A modified technique for cannulating the rete testis of the bull.


The occurrence of lymphocyte antigens on boar spermatozoa.


The pattern of ovarian secretion of oestradiol and oestrone during pregnancy and the post-partum period in the hamster.


Local production of protein during implantation in the rabbit.


Sorbitol dehydrogenase activity in spermatozoa of the domestic fowl, Gallus domesticus.


Peripheral plasma progestin levels during anoestrus, oestrus and pseudopregnancy and following hypophysectomy in ferrets.


Changes in the ovarian follicle population of mice aged 16 to 20 days.


Immunology and placentation in viviparous invertebrates.


Blastocyst-elicited immunity: failure to demonstrate immunological characteristics in mice.


Carotid cavernous fistula with spontaneous closure of the internal carotid artery.


Traumatic sacroiliac disruptions.

Traumatic sacroiliac disruptions.


The early treatment of craniocerebral missile injuries: experience with 92 cases.


Progressive pulmonary consolidation: review of cases and pathogenesis.


Studies in burns. X. Ethyl linoleate: the water-holding lipid of skin. A. The evidence.


Studies in burns. XI. Ethyl linoleate: the water-holding lipid of skin. B. Effects on in vivo burn eschar.


The absorption of C 14 -labeled Sulfamylon acetate through burned skin. I. Experimental methods and initial observations.


The absorption into burned skin of Sulfamylon acetate from 5 per cent aqueous solution.


The role of phospholipids in haemophilia A.


Hepatic porphyrins and urinary porphyrins and porphyrin precursors in liver cirrhosis.


Analysis of energy deposition in water around the site of capture of a negative pion by an oxygen or carbon nucleus.


On the relationship between the x-ray pattern, photon energy and dose for a simple phantom.


Exposure of radiologists to x-rays during chest and abdominal fluoroscopies.


A computer simulation of the performance of a spark chamber gamma camera.


Pulse shapes from particles traversing Coulter orifice fields.


A method of correcting for count rate losses in dynamic gamma camera studies.


A paper tape interface for a Picker 500 scanner.


A device for recording time reference markers during dynamic studies on the Dynacamera.


Computer evaluation of Sievert's integral by recursive formula.


The uniformity of gamma cameras.

The uniformity of gamma cameras.


Solid geometry versus plane geometry for  252 Cf sources.


Instrument nonlinearities and therapy unit timer error.


Erythrocytic enzymes of phosphorylating glycolysis. The aldolase activity in full blood, erythrocytes and plasma in women with a normal course of gestation and with intrahepatic cholestasis of pregnancy.


Malignant hyperthermia in anaesthesia.

Malignant hyperthermia in anaesthesia.


Fractures of the penis.

Fractures of the penis.


Syphilitic spinal pachymeningitis.

Syphilitic spinal pachymeningitis.


Sporotrichosis of the knee joint.

Sporotrichosis of the knee joint.


Neurofibroma of the facial nerve.

Neurofibroma of the facial nerve.


Organic confusional states.

Organic confusional states.


Intense headache as a symptom of dagga withdrawal.


Laryngeal papillomatosis.

Laryngeal papillomatosis.


Strangulated groin hernia in the tropics.


The philosophy and principles of the Midland Medical Plan.


Cirrhosis of the liver. Clinical and histological aspects seen in Rhodesian Africans.


Decerebrate rigidity due to subdural haematoma.


Bilateral rete carotidis in man. A case report.


The phenomenon of guilt and guilt feelings with special reference to the buberian approach.


Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.


Smoke of cigarettes and little cigars: an analytical comparison. Chemical data are presented from a comparison study of the smoke of cigarettes and little cigars. The tobacco products and their mainstream smokes were analyzed for a number of toxic constituents in an effort to define "smoke inhalability." This issue has particular public health importance because the difference in the inhalability of cigar and cigarette smoke is generally assumed to account for the differences in the health risk to the individual smoker.


Circadian corticosteroid periodicity: critical period for abolition by neonatal injection of corticosteroid. Circadian variation of corticosteroid concentrations in rat plasma is suppressed if corticosteroids are administered between days 2 to 4 of neonatal life, but not if they are given between days 12 to 14 of neonatal life. This indicates a critical period for the effect of corticosteroid administration on the central nervous system pathways regulating such periodicity. Circadian periodicity of corticosteroids is not affected by neonatal administration of testosterone or reserpine.


Reversed development and cellular aging in an insect. Larvae of the beetle Trogoderma glabrum undergo partially reversed development when deprived of food and water. Retrogressive larval ecdyses occur, and the larvae become diminished in size and weight. Given food, the larvae regrow, ecdyze, and regain their previous degree of maturity. Repeated cycles of retrogression and regrowth are possible. Although larval in form and organ differentiation, repeatedly retrogressed insects display a physiological deterioration suggestive of aging. A deterioration of the ability to regrow is accompanied by increasing fat body polyploidy.


Inhibition of sperm-egg interaction by specific antibody. Treatment of hamster ova, in vitro, with ovary specific antibody interferes with sperm-egg interaction by inhibiting sperm attachment to the zona pellucida and subsequent zona penetration. This inhibition results from precipitation of the zona by the specific antibody.


Moving visual scenes influence the apparent direction of gravity. When an observer views a wide-angled display rotating around his line of sight, he both feels his body tilted and sees a vertical straight edge tilted opposite to the moving stimulus. Displacement of the perceived vertical increases with stimulus speed to reach a maximum (averaging 15 degrees) at 30 degrees per second.


Synthetic rat scotophobin induces dark avoidance in mice. Two independent research groups replicate alteration of dark preference to dark avoidance by mice injected with synthetic scotophobin, a pentadecapeptide.


Histocompatibility antigens on mouse blastocysts and ectoplacental cones.


The effect of enzyme inhibitors on the solubilization of HL-A antigens with 3 M KCl.


On the possible participitation of the caudate nucleus in the development of so-called arrest-behaviour of rats.


Acid phosphatase, handy enzyme that separates the dog from the wolf.


Fine structural correlations and biochemical events in the corpus luteum.


Light and electron microscopic observations on the morphogenesis of the chorioallantoic placenta of the golden hamster (Cricetus auratus). Days seven through nine of gestation.


Innervation of pulmonary alveoli of the mouse lung: an electron microscopic study.


Ultrastructural studies of transmural migration of blood cells in the bone marrow of rats, mice and guinea pigs.


Effects of embryonic overgrowth on the avian optic tectum.


Smallpox vaccinations.

Smallpox vaccinations.


Benefits and risks in nuclear medicine.

Benefits and risks in nuclear medicine.


Radiation exposure from industrial microwave applications.


Communicable disease control and public policy in the 1970s--hot war, cold war, or peaceful coexistence?


Tuberculosis in suburbia--new indices for an old disease.


A computer system for treatment evaluation at the Community mental health center.


Consultation, education, and training perspectives from an urban community mental health center: the context of dilemma.


Subsequent pregnancies among teenage mothers enrolled in a special program.


Pregnancy and special education: who stays in school?


A comparative study of public health nurse teaching in groups and in home visits.


Broadening the focus of suicide prevention activities utilizing the public health model.


A three-year longitudinal evaluation of the costs of a family planning program.


An epidemiological study of timing failure type pregnancies.


Potentiometric determination of monuron in herbicide formulations.


The determination of steam-volatile N-nitrosamines in foodstuffs by formation of electron-capturing derivatives from electrochemically derived amines.


Cross-national diagnosis of schizophrenia in twins. The heritability and specificity of schizophrenia.


The prediction of outcome in schizophrenia. I. Characteristics of outcome.


Catatonic behavior, viral encephalopathy, and death. The problem of fatal catatonia.


Externalization and existential anguish in the borderline patient.


The expression of feelings.

The expression of feelings.


Hysteria. A neurobiological theory.

Hysteria. A neurobiological theory.


The remembered mother and the fantasized mother. A crisis of middle age.


Excommunication as a family therapy technique.


Characteristics of drivers involved in single-car accidents. A comparative study.


Treatment of tardive dyskinesia. 3. Clinical efficacy of a dopamine competing agent, methyldopa.


Psychosocial sequelae of therapeutic abortion in young unmarried women.