Ultrathin supporting films in electron microscopy of unstained biological macromolecules. A simple technique is described, in which the increase in thickness of a carbon film is controlled. Films up to 10-15 A in thickness, which are both continuous and strong enough for use as supporting films in electron microscopy, can be easily obtained by this routine method. Images are shown of unstained ribosomial subunits and tropocollagen molecules on 15 A carbon films.


A sequential study of intravenous analgesic treatment during labour.


Preliminary experience with a circuit to increase the airways pressure in adults breathing spontaneously.


A whole cell mounting technique for detecting Acholeplasma laidlawii A on the surface of cultured cells.


Human leukocyte interferon: production, purification, stability, and animal experiments.


Flupentixol and flupentixol decanoate, with special reference to their antipsychotic effect.


The nature and function of chloroplast protein synthesis.


A survey of cytokinins and cytokinin antagonists with reference to nucleic acid and protein metabolism.


Biosynthesis of cyanogenic glycosides.

Biosynthesis of cyanogenic glycosides.


Attempts towards control of schistosomiasis in Egypt.


[Indanyl carbenicillin and urogenital infections].


Erythropoietin.

Erythropoietin.


Immunology of gonadal steroids.

Immunology of gonadal steroids. The immunology of gonadal steroids is reviewed.  Characteristics of antibodies to steroids, use of antibodies for the localization of steroids in tissues and physiological studies using antibodies to steroids (inhibition of exogenously administered hormones, in vivo specificity of the  steroid-antibody reaction, mechanism of action of antibodies, inhibition of endogenous circulating hormones and use of antibodies to study the role of hormones in various physiological and pathological processes) are the main topics.  Therapeutic possibilities of immunization with steroids are many.  Active immunization with estrogen conjugates could cause lasting anovulation.  This condition could be reversed by the administration of synthetic estrogens not inhibited by antibodies.  Also, antibodies to progesterone could be used to terminate unwanted pregnancies.  Antibodies have unique advantages over other methods by which inactivation of a hormone is sought since antibodies have no biological activity other than by their capacity to inactivate the homologous hormone in the peripheral circulation.


Hormonal control of ovoimplantation.

Hormonal control of ovoimplantation. Literature on the hormonal control of ovoimplantation is reviewed.  Areas reviewed include the timing of events of early pregnancy and the initiation of ovoimplantation, the role of ovarian hormones in implantation and the hypothalamohypophyseal regulation of implantation, the morphological and metabolic  effects of ovarian hormones on the relationships between the ovum and endometrium, lysis of the zona pellucida, the effects of ovarian hormones on changes in endometrial receptivity and the conditioning of the endometrium by these hormones,  the recognition of ovarian hormones by endometrial cells and cell transcriptional events, and the mechanisms of the repression and activation of the blastocyst.


Skin grafting using ethyl chloride.

Skin grafting using ethyl chloride.


Reflex responses of respiratory muscles to tilting and positive pressure breathing. We have recorded the action potentials of muscle fibres of External Oblique in anaesthetized rabbits in supine and horizontal position. During head-up tilting the inspiratory activity is inhibited and the abdominal activity is excited. Both these two responses are reflexly mediated through vagal afferent fibres. The positive pressure was chosen as to determine a shift in end-expiratory volume similar to that induced by the head-up tilting. Also at positive pressure breathing (PPB) the abdominal activity increases but less than during head-up tilting. This result seems to indicate the importante of the proprioceptive afferents of the external oblique during the vertical posture. The blockade of vagal nervous conduction markedly reduces the abdominal activity both during tilting and P.P.B. and similar results are obtained either by "total" or "partial" vagal blockade. Therefore it seems possible to conclude that both these two reflexes (introduced by head-up tilting and PPB) be due to the activation of the same receptors (pulmonary stretch receptors).


Hormonal effects on human myometrial activity. Literature on the effects of hormones on human myometrial activity is reviewed.  The effects of estrogens, gestagens, and prostaglandins on myometrial activity in pregnant and nonpregnant women, and those of maternal and fetal corticosteroids, biogenic amines, and oxytocin and vasopressin are discussed.  Estrogens produce small, frequent, local, and nonpropagated contractions of the myometrium, while gestagens produce contractions of higher amplitude, longer duration, and lower frequency.  Maternal and fetal corticosteroids have some importance for myometrial activity of pregnancy in some animals, but their role in humans remains obscure.  Epinephrine and norepinephrine stimulate myometrial activity in humans, though their physiologic and therapeutic importance is doubtful.  The same holds for serotonin.  Oxytocin in large doses stimulates myometrial activity during the proliferative stage of the cycle, but is without effect in smaller doses.  During pregnancy, oxytocin progressively stimulates myometrial activity, particularly toward the end of pregnancy.  Oxytocin is often used to initiate and stimulate labor.  Vasopressin, on the other hand, stimulates myometrial activity during the secretory phase of the cycle, especially around the onset of menstruation.  Vasopressin has a less marked effect during pregnancy than oxytocin, and its effects are not enhanced as pregnancy comes to term.  The fetus is known to produce considerable amounts of oxytocin and vasopressin during labor, though the significance of this contribution remains to be elucidated.  Prostaglandins have a potent stimulatory effect on myometrial activity in both pregnant and nonpregnant women.  The possibility that prostaglandins play a physiologic role in the onset of myometrial activity remains to be determined.


[Endopleural use of doxycycline in inflammatory pleural effusions: its possibility and usefulness].


Involvement of calcium in exocytosis and the exocytosis--vesiculation sequence.


The dual role of sialic acid in the hepatic recognition and catabolism of serum glycoproteins.


Wenela-past and present.

Wenela-past and present.


Genetic regulation of the structure of blood-group-specific glycoproteins.


Cell-surface glycoproteins in normal and transformed cells.


The nature and metabolism of the carbohydrate-peptide linkages of glycoproteins.


The heterogeneity of glycoproteins.

The heterogeneity of glycoproteins.


Analysis of glycoproteins.

Analysis of glycoproteins.


Enzymic assembly of the carbohydrate units of glycoproteins and the role of lipid intermediates.


The subcellular sites of glycosylation.

The subcellular sites of glycosylation.


Sialic acids: their analysis and enzymic modification in relation to the synthesis of submandibular-gland glycoproteins.


The place of surgical excision in the management of locally advanced breast cancer.


Calorimetric studies on the in vitro polymerization of Pr. mirabilis flagellin.


Factors affecting the development of secretory immunoglobulin A in the saliva of human infants.


Critique of "Factors affecting the development of secretory immunoglobulin A in the saliva of human infants".


Ionic channels through the axon membrane (a review).


Women...now and then.

Women...now and then.


Complete denture construction.

Complete denture construction.


Endodontics 1972.

Endodontics 1972.


The status of standardised endodontic instruments.


The stress of hot environments.

The stress of hot environments.


Manufacturers. An index to dental manufacturers with their respective dealer/distributor organizations.


Dealers & distributors. Names, addresses, telex and telephone numbers of suppliers serving the Canadian dentist.


Trade names. Equipment, drugs and supplies by trade name and manufacturer.


Laboratories. An index to dental laboratories serving the Canadian dentist.


Products. A listing of major equipment, drugs and supplies with manufacturers.


Albert the Great on the classification and localization on the internal senses.


Know your colleague. Dr. Perry Levinsohn--antique collector.


The methodology of Freud. In connection with the study by W.W. Meissmer.


Neuroblastoma.

Neuroblastoma.


Advances in the treatment of tumors arising in bone.


Genitourinary tumors in children.

Genitourinary tumors in children.


Treatment of intracranial neoplasms in children.


Specific receptors of the steroid hormones in breast cancer.


Hormonal therapies in breast cancer.

Hormonal therapies in breast cancer.


Cause and prevention of lung cancer.

Cause and prevention of lung cancer.


Breast cancer in men.

Breast cancer in men.


The growth characteristics of lung cancer and its application to treatment design.


Cell culture of the endocrine pancreas of the mouse in chemically defined media.


Continuous observation diffusion chamber for cell and organ cultures.


Cytopathologic diagnosis of lung cancer.


Mediastinoscopy for assessing mediastinal spread in clinical staging of lung carcinoma.


Immunotherapy as related to lung cancer: a review.


Interpretations of survival-type data arising from clinical trials.


Cancer immunotherapy: an overview.

Cancer immunotherapy: an overview.


Fundamental concepts in tumor immunology: a brief review.


BCG vaccine in perspective.

BCG vaccine in perspective.


Use of BCG in the treatment of human neoplasms: a review.


Intensification of immune reactions of patients to cultured sarcoma cells: attempts at monitored immunotherapy.


Corynebacterium parvum as an immunotherapeutic anticancer agent.


Immunotherapy of cancer with "immune" RNA: current status.


Immunochemotherapy of human cancer.

Immunochemotherapy of human cancer.


Health care in Canada today.

Health care in Canada today.


Report of the Subcommittee on Avian Influenza to the Committee on Transmissible Diseases of Poultry.


Translocation of heavy metals in human food chains.


On the control of transmissible gastroenteritis of swine.


An indirect fluorescent antibody test for antibodies to Nosema cuniculi (Encephalitozoon) in rabbits.


Immunofluroescence of spirochetes with serum from swine recovered from swine dysentery.


Diagnostic precedures in animal mycoplasma infections.


Use of suckling mice for detection of enteropathogenicity of Escherichia coli isolated from calves and pigs.


Dr. Carroll K. Mingle awardee of the Honorary Diploma, American Veterinary Epidemiology Society October 17, 1974 Roanoke, Virginia.


The world epizootiology of vesicular disease.


Host animal efficacy and laboratory potency tests for nonspecific bacterins, mixed bacterins, and bacterial antiserums.


Malignant disease.

Malignant disease.


Endocrine diseases.

Endocrine diseases.


Gastrointestinal diseases.

Gastrointestinal diseases.


Dermatological disorders.

Dermatological disorders.


Cardiac diseases.

Cardiac diseases.


Renal diseases.

Renal diseases.


Infection.

Infection.


New hand instruments for subgingival scaling.


Chronopharmacology in man.

Chronopharmacology in man.


The history of dental hygiene in the United Kingdom.


M.B.E. award to Mrs. Wendy Leech.

M.B.E. award to Mrs. Wendy Leech.


A correlative radioautographic, fluorescent, and histochemical technique for cytopharmacology.


Andrew Murray Bain, B.Sc. (Edin), M.A.C.V.Sc.


William Webster, B.V;Sc;, H.D.A., F.A.C.V.Sc.


Oral biology in Japan 1973-1974. 1. Oral anatomy.


Dental history in Japan 1973-1974.

Dental history in Japan 1973-1974.


Japanese Association for Dental Science.


Dental practice administration in Japan 1973-1974.


Oral biology in Japan 1973-1974. 3. Oral pathology.


Oral biology in Japan 1973-1974. 4. Oral microbiology.


Oral biology in Japan 1973-1974. 5. Oral physiology.


Oral biology in Japan 1973-1974. 6. Dental pharmacology.


Conservative dentistry in Japan 1973-1974.


Orthodontics in Japan 1973-1974.

Orthodontics in Japan 1973-1974.


Dental health in Japan 1973-1974.

Dental health in Japan 1973-1974.


Oral biology in Japan 1973-1974. 2. Dental histology.


Dental materials in Japan 1973-1974.

Dental materials in Japan 1973-1974.


Dental radiology in Japan 1973-1974.

Dental radiology in Japan 1973-1974.


Periodontology in Japan 1973-1974.

Periodontology in Japan 1973-1974.


Dental anesthesia in Japan 1973-1974.

Dental anesthesia in Japan 1973-1974.


Materials science in Japan 1973-1974.

Materials science in Japan 1973-1974.


Fauchard medalist's theme: Look backward as a prologue to progress.


PFA honors Dr. Blackerby, installs Dr. Bowers.


The fallacy of polishing composite restorations.


Technic for creating disposable inlay rings.


The status of cantilever bridges.

The status of cantilever bridges.


Have bus: will travel.

Have bus: will travel.


Clinical and technical measures in controlling surface roughness and irregularity of cast restorations.


1. Dental suffragettes--women in dentistry.


Tumours of the stomach.

Tumours of the stomach.


Tumours of the soft tissues.

Tumours of the soft tissues.


Tumours of the auditory sebaceous glands.


The extraction of teeth. 4. Surgical extractions.


Tumours of the bone.

Tumours of the bone.


Complete denture replacement for geriatric patients.


Tumours of the haematopoietic system.

Tumours of the haematopoietic system.


Tumours of the salivary glands.

Tumours of the salivary glands.


Tumours of the oesophagus.

Tumours of the oesophagus.


Leonard Charles Abrahams.

Leonard Charles Abrahams.


An evaluation of an in vivo enamel acid etch biopsy technique for fluoride determination.


Abe Kessel.

Abe Kessel.


Dental caries in ancient and modern Hawaii.


The role of radioisotopes in the diagnosis of bronchial cancer.


Prevention. A physician who cares.

Prevention. A physician who cares.


The bonding of sealants to enamel.

The bonding of sealants to enamel.


Honors presented to Dr. M.K. Hine.

Honors presented to Dr. M.K. Hine.


The future of pit & fissure sealants.

The future of pit & fissure sealants.


Occlusal sealing: rationale of the technique and historical review.


A new 133Xe-radiospirometric multidetector system using microprocessor techniques for immediate evaluation of results. A preliminary report.


Effect of fluoride intake on osteoporosis & other rarefying bone disease: a review.


A salute to Dr. Jack D. Carr.

A salute to Dr. Jack D. Carr.


Old diplomas sought for dental library.

Old diplomas sought for dental library.


Perforation of the palate associated with suction disc denture.


Macomb District Dental Society 1974-1975 membership roster.


Macomb District Dental Hygienists Society officers 1974-1975.


1974-1975 Macomb Dental Society specialist roster.


Two "first" student members.

Two "first" student members.


Introduction to the first Sheldon Friel memorial lecture.


Treatment of collapse in cleft palates by rapid expansion and bone grafting.


Incidence of drug resistance in Escherichia coli isolated from scouring calves.


Microorganisms isolated from cows infected with mastitis at Benghazi.


Studies on growth inhibition of Mycoplasma mycoides by homologous immune serum in liquid medium.


Comparative study by the frequencies of the rotatory and sinusoidal stimulation with a stereotaxic experimental method. The analysis of the records, obtained with six rabbits which were submitted to the combined antagonistic stimulations, peripheric rotatory and central stereotaxic, has not allowed to find a systematic relationship between the two rotatory tests. If the physical equivalence seems to be real where one takes the RMS value of the sinusoidal accelerations (and not the maximum acceleration for a half-period) the physiological equivalence however has still to be sought after.


[Assuring quality dental care].

[Assuring quality dental care].


Claude E. Forget, Minister of Social Affairs.


World Health Organization.

World Health Organization.


Specific antibodies to react with oral microorganisms in inflamed human gingiva.


Submerged functional predictive endosteal blade implants.


Endodontics: past and future.

Endodontics: past and future.


The use of stress breakers in removable and fixed prosthese: their importance in relation to implants.


Bennett movement of mandible.

Bennett movement of mandible.


Surgery of the temporomandibular joint--a review.


Your Oklahoma State Dental Association directory 1973-1974.


The President's message.

The President's message.


Meet the President.

Meet the President.


The changing practice of dentistry.

The changing practice of dentistry.


Your Oklahoma Dental Association directory 1974-1975.


Introducing your new president.

Introducing your new president.


Adhesion of zinc phosphate cement and polycarboxylate cement to ivory.


Dr. Charles H. Moses.

Dr. Charles H. Moses.


Facts and figures.

Facts and figures.


A decade of dental education in Gujarat.


Experimental, social and practical bases of prevention of dental caries in the child.


Dr. Henry Isaiah Dorr, alumni benefactor.


Do's and don'ts.

Do's and don'ts.


Meet Dr. Minoru Nakahara.

Meet Dr. Minoru Nakahara.


Homemade dentures.

Homemade dentures.


Good as gold.

Good as gold.


Restriction on the secretion of hemolytic antibodies of more than one allotypes by rabbit splenocytes.


Management of anovulation.

Management of anovulation.


The reproductive endocrinology of childhood and adolescence.


Specialization of antibody forming cells.


Diffusion of anti-tumor drugs through membranes from hydrophilic methacrylate gels. Permeation parameters of four anti-tumor drugs across membranes prepared from hydrophilic methacrylate gels were measured and compared with the permeation of NaCl. It was found that by increasing the ratio of butyl methacrylate (BMA) to hydroxyethyl methacrylate (HEMA), the rate of diffusion can be lowered to practically zero at 20% BMA. However, this decrease is different with various drugs due to the interaction of the drug with the gel. Differences by a factor of two were found in our set of drugs. Therefore, each new drug should be tested in this way. In addition a routine testing of dialysing devices by an NaCl solution is suggested as a method for detecting technological imperfections and calibrating the deviations from standard parameters. A chemical modification of the membrane is recommended as the best way for controlling the permeation rate.


In memoriam--Dr. Jan Frederik Vercueil.

In memoriam--Dr. Jan Frederik Vercueil.


The sixth Abe Kessel memorial lecture: Prof. F.A. Hossack: 19 August 1974.


Vote of thanks to Professor Hossack.

Vote of thanks to Professor Hossack.


Periodontics 1972: a review.

Periodontics 1972: a review.


The laser in dentistry: a review of the literature.


Fluoridation: literature review for 1972.


Facial pain and its management--a clinical study.


Full denture construction--a simple technique.


Clinical evaluation of heat method for bleaching of discoloured mottled teeth.


Obituary. Dr. Sunder J. Vazirani.

Obituary. Dr. Sunder J. Vazirani.


Altering canines to resemble lateral incisors: a new technique.


Dean Gordon Nikiforuk.

Dean Gordon Nikiforuk.


Dental Corps Flag Officers change commands.


Oral pathology and the histopathology service.


Membership list.

Membership list.


The first oral endosteal metallic implants. A Georgetown University school of dentistry clinical study.


Complete denture impressions--a recent history.


Peter Zakarow, new R.C.D.S. president.

Peter Zakarow, new R.C.D.S. president.


Use of a filled diacrylate as fissure sealant: one-year clinical study.


Skin grafting using ethyl chloride.

Skin grafting using ethyl chloride.


Self-scaling in the dentiscope.

Self-scaling in the dentiscope.


Mr. Bernard Engelsman.

Mr. Bernard Engelsman.


Splinting can save mobile teeth.

Splinting can save mobile teeth.


Farewell to Sir Robert Bradlaw.

Farewell to Sir Robert Bradlaw.


Bio-electronic determination of endodontic working lengths.


Pictorial review of the surgeon general's office (1969-1973) VADM George M. Davis, MC, USN.


The surface ultrastructure of normal, denture-bearing and denture stomatitis mucosa.


1974--a historic year in Ohio dentistry.


Evaluation of vital and devitalizing methods for pulpotomy in deciduous teeth.


The healing of extraction wounds in the presence of foreign bodies (fragments of silver amalgam and of zinc oxide-eugenol impression paste).


Team approach to oral health treatment of pre and post renal transplant patients.


Membership roster.

Membership roster.


Water fluoridation in the UK?

Water fluoridation in the UK?


Precision attachment tissue bar: report of case.


A search for caries-free teeth.

A search for caries-free teeth.


Starflite Satellite mobile unit.

Starflite Satellite mobile unit.


The genetic control of protein synthesis: The haemoglobin model. The major steps in haemoglobin synthesis in red cell precursors are now worked out and only details of specific mechanisms remain to be filled in. Thus the major steps in the production of a globin chain are the transcription of large-molecular-weight precursor mRNA (Hn RNA) from the appropriate gene, the cleavage of Hn RNA to produce definitive template mRNA which diffuses into the cell cytoplasm, the processes of chain initiation, translation, and termination, and finally the association of subunits to form a stable tetramer. From what little information there is it appears that this complex series of events is controlled at several levels but that the major control mechanisms are mediated in the processes of transcription rather than translation. There is increasing evidence that the chromatin proteins, particularly the acidic proteins, have specific functions in maintaining areas of DNA repressed and the activation of the haemoglobin loci results from complex interactions with external inducers, the nature of which is not yet known. Virtually nothing is known about the factors involved in the switch from the intrauterine to adult haemoglobins although this appears to be a coordinated event throughout the erythropoietic tissue of the fetus. The isolation and characterization of human mRNA has made possible both the study of the function of thalassaemic mRNA in heterologous systems and , more recently, its quantitation in abnormal red-cell precursors. Furthermore the ability to make cDNA using viral re verse transcriptase has made possible the estimation of the number of haemoglobin genes, both in normal human subjects and in those with different forms of thalassaemia and other genetic disorders of haemoglobin production.


Management of sickle-cell disease.

Management of sickle-cell disease.


Simple bacterial systems for detecting mutagenic agents.


Mitotic recombination in yeast as a test of genetic damage.


Some observations on the reduction of 2,3,5, triphenyltetrazolium chloride by Escherichia coli.


The glycogen storage diseases.

The glycogen storage diseases.


Evaluation of Doppler test for venous thrombosis in obstetrics and gynecology.


Molecular variation in relation to purine metabolism.


Puberty-physiological mechanisms of control.


Aberrant ovulation--consequences on fertility and embryonic development.


Dynamics of pituitary gonadotropin secretion.


Induced ovulation and fertility in prepuberal cattle, sheep and swine.


Consequence of additional ova to variation in litter size in swine.


Relative biological effectiveness of fast neutrons for effects on normal tissues.


Repair of X-ray damage to bacterial DNA.


Studies of oxygen supply of liver grafts.


Immunopharmacological aspects of bronchial asthma.


Clinical significance of measurement of reaginic (IgE) antibody by RAST.


Development of the immune response.

Development of the immune response.


Dermatological allergy.

Dermatological allergy.


Paediatric gastrointestinal allergy.

Paediatric gastrointestinal allergy.


The Sloan-Kettering affair: could it have happened anywhere?


Immunology of the lower respiratory tract.


Bilateral lung transplantation. Preliminary report.


Effect of N-nitroso-N-methylurea on viability and mutagenic response of repair-deficient strains of Escherichia coli.


Possible pathogenetic interrelationships among proliferative glomerulonephritides.


The isolation and characterisation of a mutant of Salmonella typhimurium defective in mutation frequency decline.


Lipoid nephrosis: a reassessment.

Lipoid nephrosis: a reassessment.


Alkylating agents in the treatment of nephrotic syndrome.


Mesangial IgA deposits.

Mesangial IgA deposits.


Glomerular morphology, natural history and treatment of children with IgA-IgG mesangial nephropathy.


Serial biopsies in diffuse proliferative glomerulonephritis in adults: an attempt for a better understanding of sporadic acute glomerulonephritis.


Pathology of membranous glomerulonephritis.


Dense deposit disease: a subgroup of membranoproliferative glomerulonephritis, identified by electron microscopy.


The natural history of membranous glomerulonephropathy.


The natural history of membranoproliferative glomerulonephritis: its relation to the hypocomplementemia.


Characterization of mixed membranous and proliferative glomerulonephritis: recognition of three varieties.


The health condition of the elderly in Stockholm.


A clinician's view of the classification of glomerulonephritis.


A systematic informational approach to the planning of health care.


Streptococcal surveillance in remote Arctic populations. The development of a system for detection of Group A pharyngitis and the prevention of nonsuppurative sequelae.


History of Greenland.

History of Greenland.


Forum on historical research. Response in anger--an unsent letter to the editor: investigation of a letter written by Florence Nightingale.


Congress copes with the nurse shortage, 1941-1971: dynamics of congressional nurse education policy formulation.


Critique of 'Congress copes with the nurse shortage, 1941-1971: dynamics of congressional nurse education policy formulation'.


Protein metabolism in response to injury and other pathological conditions.


Comparison of pethidine and tilidine in man.


Primary amebic meningoencephalitis.

Primary amebic meningoencephalitis.


The immunobiology of human malignant disease.


Rubella in pregnancy.

Rubella in pregnancy.


Antenatal and perinatal anoxia as the probable cause of damage to the brain during birth.


Stimulation of phospholipase A2 of synaptosomes of guinea-pig brain by noradrenaline and other amines.


Vitamin Q.

Vitamin Q.


Present trends of kinin research.

Present trends of kinin research.


Corneal arcus and hyperlipoproteinaemia. A corneal arcus is a lipid deposition mainly consisting of cholesterol and phospholipid. Its prevalence varies in different populations and races, increases with age and is greater in the male. Earlier studies related the presence and severity of a corneal arcus to plasma lipid levels and linked it with certain familial hyperlipidaemias. The recent reclassification of such disorders in terms of hyperlipoproteinaemia now links the premature occurrence of an arcus with familial Type II and III hyperlipoproteinaemia. Other rare plasma lipid disorders in which corneal opacities occur are Tangier Disease and lecithin:cholesterol acyl transferase deficiency.


Glutathione, metabolism and function via the gamma-glutamyl cycle.


Inhibitors of RNA and DNA biosynthesis.

Inhibitors of RNA and DNA biosynthesis.


Artificial eyes in ancient Egypt.

Artificial eyes in ancient Egypt.


Early sequence of biochemical events in the action of follicle stimulating hormone on the testis.


The estrogen receptor: a minireview.

The estrogen receptor: a minireview.


Histamine and microcirculation.

Histamine and microcirculation.


Sutures for anterior segment surgery.

Sutures for anterior segment surgery. A review of available suture materials in anterior segment surgery has been undertaken. The characteristics of each material and the procedures for which each may be useful have been described.


Studies on human prolactin physiology.

Studies on human prolactin physiology.


Speculations on the biochemical pharmacology of ethanol.


Ovarian effect of periodic episodes of elevated serum follicle stimulating hormone (FSH).


Reaction of the lung to air pollutant exposure.


Non-histone chromosomal proteins in normal and abnormal growth.


Electronic biology and its relation to cancer.


Effects of intracerebral administration of piperidine on EEG and behavior.


Subcellular localization of 3H-piperidine in the rat brain.


Prenatal diagnosis of genetic disease.

Prenatal diagnosis of genetic disease.


A paradoxical castration effect on LH-RH levels in male rat hypothalamus and serum.


The visualization of receptors for the Fc portion of the IgG molecule on human neutrophil leukocytes.


Effects of drugs on nutrition.

Effects of drugs on nutrition.


The mechanisms of action of L-dopa in Parkinson's disease.


Glucose metabolism during osmotic stress in isolated axons of Eriocheir sinensis.


Nerve growth factor.

Nerve growth factor.


Brain mechanisms in motor control.

Brain mechanisms in motor control.


The role of catecholamines and acetylcholine in the regulation of endocrine function.


Regulation of serotonin synthesis.

Regulation of serotonin synthesis.


Programmed cell death.

Programmed cell death.


Excision repair of DNA base damage.

Excision repair of DNA base damage.


Stimulation of prostaglandin F synthesis by luteinizing hormone in rabbit ovarian follicles grown in organ culture.


Deficiency of erythrocyte sodium pump activity in bipolar manic-depressive psychosis.


Description and statistical analysis of fine structural changes in tendon fibrocytes treated with dimethyl sulfoxide.


Glucose-6-phosphate dehydrogenase deficiency: a novel role for thyroxine in peroxide-induced hemolysis.


Relationship between environmental light intensity and retina-mediated suppression of rat pineal serotonin-N-acetyl-transferase.


Pain-induced alteration of glutamate in periaqueductal central gray and its reversal by morphine.


Cholesterol and bile acids via acetate from the insect juvenile hormone analog methoprene.


Pineal hydroxyindole-0-methyl transferase and N-acetyl transferase during sexual maturation of coturnix quail.


Differential protein and RNA synthesis of rat kidney cortex and medulla.


Vascular reactivity in hypertensive rats after treatment with anti-hypertensive agents.


Biosynthesis of brain 2-phenylethylamine: influence of decarboxylase inhibitors and D-amphetamine.


Diurnal variation in the feeding pattern of rabbits.


Synergistic and additive effects of kinetin and ethrel on the release of seed dormancy.


d-LSD binding to brain homogenates: possible relationship to serotonin receptors.


Impairment of hepatic pyruvate metabolism in phenylketonuria.


Growth responses of cell cultures in a galactose medium.


Effects of acute and chronic morphine on regional rat brain acetylcholine turnover rate.


Measurement of acetylcholine turnover rate in discrete areas of rat brain.


Effects of tricyclic antidepressants upon human platelet monoamine oxidase.


Rapid transesterification of bilirubin glucuronides in methanol.


The effects of dark and light on the functional recovery following lateral hypothalamic lesions.


Biological effects of D2O administration to Coturnix japonica.


Increased human platelet monoamine oxidase activity during lithium carbonate therapy.


Alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis. Aminopyrine demethylase activity and ribosome-membrane interaction.


Extrapineal N-acetyltransferase activity in rat brain.


Neonatal 6-hydroxydopamine treatment: noradrenaline levels and in vitro 3H-catecholamine synthesis in discrete brain regions of adult rats.


Influence of potassium chloride on alcohol absorption.


Excitatory effects of 5-hydroxytryptamine, veratridine and phenyl diguanide on sensory ganglion cells of the nodose ganglion of the cat.


Simultaneous determination of 3,4-dihydroxyphenylacetic acid and homovanillic acid in milligram amounts of rat striatal tissue by gas-liquid chromatography.


Presence of two protein kinases in highly purified rat liver nucleoli.


Norcocaine: a pharmacologically active metabolite of cocaine found in brain.


The graduate students: an awakening minority in the American Association of Orthodontists.


An electromyographic investigation of patients with a normal jaw relationship and a Class III jaw relationship.


The student and the Association.

The student and the Association.


Interproximal stripping.

Interproximal stripping.


Precautions to be taken during press interviews.


Asepsis in large-bowel surgery.

Asepsis in large-bowel surgery.


The value of radiomanometry in bile duct surgery.


The place of laparotomy in the management of pyrexia of unknown origin.


Jaw tumours in Rhodesia.

Jaw tumours in Rhodesia.


Control of pulmonary embolism by removal of residual thrombus from the iliac and femoral veins.


Professional standards review organizations and their implications for physicians. II. Thromboembolism on mitral valve prosthesis.


The surgical therapy for pulmonary artery--right ventricular discontinuity.


Evaluation of composite graft replacement of the aortic root and ascending aorta.


Avoiding postoperative dysrhythmias and venous obstruction following Mustard's operation. Technical considerations.


Critical analysis of pulse generator replacement.


Emboli (debris) produced by bubble oxygenators. Removal by filtration.


Hyperlucent lung. Pathophysiology and surgical management.


Simplified technique for aortic arch replacement. First-stage right subclavian-to-left carotid artery bypass.


Coronary embolism following mitral valve replacement. Intraoperative diagnosis and successful embolectomy.


Transposition of the great arteries.

Transposition of the great arteries.


Tympanoplasty and age.

Tympanoplasty and age.


Hearing in ethnically different longshoremen.


A comparative study of the ototoxicity of tobramycin and gentamicin.


Studies in impedance audiometry. I. Normal and sensorineural ears.


Diagnosis and management of far-advanced otosclerosis.


Intra-epithelial glands in human eustachian tube.


Vestibular aqueduct and endolymphatic duct in Menière's disease.


Changes in perilymph glucose concentration. Occurrence in hyperglycemia and hypoglycemia.


Floor ataxia test battery. Results from an 9- to 18-year-old group.


Arachnoid villi obstruction in the cochlear aqueduct.


Intracochlear neurilemmoma.

Intracochlear neurilemmoma.


Radiographic pathognomonic findings of leprosy. A report of two cases.


Pathologic Quiz Case 1. Sarcoidosis of the parotid gland.


First and second branchial syndrome.

First and second branchial syndrome.


Pathologic Quiz Case 2. Neurilemmoma of the palate with overlying ulceration.


Diverting ileostomy for colonic Crohn's disease. Part I: Significance of ulcers 5 mm in depth or deeper on the preoperative barium enema.


Neoplasia of the colon over a long segment.


Diverting ileostomy for colonic Crohn's disease. Part 2: Radiological findings in the colon following diversion.


Urographic contrast agents. Comparison of sodium and methylglucamine salts of iothalamate monomer and dimer.


Aberrant vessels in congenital hydronephrosis.


Meglumine iocarmate (Dimer-X) ventriculography.


Pyelotumour backflow: a manifestation of renal cell carcinoma.


Perinephric masses--a cause of renovascular hypertension.


Respiratory stridor--a challenge for the paediatric radiologist.


Curvilinear calcifications in four uncommon benign renal lesions.


Pneumoconiosis in women.

Pneumoconiosis in women.


The management of cervical lymph node metastases by hyperbaric oxygen and radiotherapy.


The treatment of squamous-cell carcinoma of the lower lip by rigid implants.


Clinical observations on the time factor in interstitial radiotherapy using iridium-192.


Carcinoma of the breast. Local prognosis after radiotherapy using air wedges for chest wall irradiation.


Modifications of experimental allergic encephalomyelitis in the rat by Angiostrongylus cantonensis larvae.


Central and peripheral contributions to localization of body parts: evidence for a central body schema.


Classical eyeblink conditioning in the bilaterally hemispherectomized cat.


Localization of neurons supplying the extraocular muscles in the kitten using horseradish peroxidase.


Uptake of [3H]colchicine from silastic implants by mammalian nerves and muscles.


Neuroblastoma cells in culture: 32P-phosphoprotein labeling and protein kinase activity.


Comparison of healing process in transected spinal cords grafted with autogenous brain tissue, sciatic nerve, and nodose ganglion.


Pallidal and entopeduncular intracellular responses to striatal, cortical, thalamic, and sensory inputs.


Evidence of a contractile mechanism in the taste bud of the mouse fungiform papilla.


Carotid sinus baroreceptor responses to recurrent trapezoidal pressure pulses.


Alteration of neuronal synaptic complement during regeneration and axonal sprouting of rat spinal cord.


Mycobacterial skin infection by an unidentified species. A report of 29 patients.


Complement in pericardial fluid of lupus erythematosus. Studies in two patients.


Disseminated intravascular coagulation during heparin therapy.


Hypouricemia, hypercalciuria, and decreased bone density: a hereditary syndrome.


Reduction of digoxin toxicity associated with measurement of serum levels. A report from the Boston Collaborative Drug Surveillance Program.


Expensive beef: a blessing in disguise?

Expensive beef: a blessing in disguise?


Renal lithiasis in gastrointestinal disease.


Gallstones with ulcerative proctitis.

Gallstones with ulcerative proctitis.


Pulmonary edema and salicylate intoxication.


Cerebellar ataxia with Mycoplasma pneumonia.


Neutropenia, elevated rheumatoid factor, splenomegaly, and absence of rheumatoid arthritis.


Cross-indexed file for medical literature.


Care of patients.

Care of patients.


Identification of patients.

Identification of patients.


Ethics of renal biopsy.

Ethics of renal biopsy.


Sarcoidosis and hepatic granulomatosis.

Sarcoidosis and hepatic granulomatosis.


Dialysis fistula and heart failure.

Dialysis fistula and heart failure.


Practical application of acupuncture analgesia.


Genetic apparatus of Stylonychia sp.

Genetic apparatus of Stylonychia sp.


Evidence for a tumour-associated antigen in human malignant melanoma.


6-Azauridine-5'-phosphoric acid: unusual molecular structure and functional mechanism.


Nuclear DNA content variability in Xenopus laevis: a redundancy regulation common to all gene families.


Latimeria chalumnae: reproduction and conservation.


Psychiatric decisions.

Psychiatric decisions.


Resonance Raman spectroscopy of the photoreceptor-like pigment of Halobacterium halobium.


Collection, motility and storage of spermatozoa from the African elephant Loxodonta africana.


1,25-Dihydroxycholecalciferol: inhibition of action in organ-cultured intestine by actinomycin D and alpha-amanitin.


DES banned again.

DES banned again.


X-ray photoelectron studies of magnesium ions bound to the cell walls of gram-positive bacteria.


Going in the red.

Going in the red.


Nucleolar single stranded DNA.

Nucleolar single stranded DNA.


Biological method of estimating smoke and sulphur dioxide pollution.


Haemodynamics in the Sauropoda.

Haemodynamics in the Sauropoda.


Reasoning and Piaget.

Reasoning and Piaget.


Sensitivity in the World Dynamics Model.


Involvement of a carbohydrate group in the active site for surface guided reassociation of animal cells.


Two component system for surface guided reassociation of animal cells.


Recognition of protein structure in leukocyte chemotaxis.


Tetraploid mouse embryos produced by cytochalasin B during cleavage.


Natural and synthetic sources of circulating 25-hydroxyvitamin D in man.


First record of the Palaeocene primate Chiromyoides from North America.


Amphibious nature of visual acuity in the Asian "Clawless" otter.


Linguistic structure and speech shadowing at very short latencies.


Telemetry in animal and human biometeorology.


Animal production in the desert.

Animal production in the desert.


Near future prospects of the meteorological environment in developed countries. Air pollution, its causes, biological effects on plants, animals and man and possible means of prevention.


Climate of the urban biosphere.

Climate of the urban biosphere.


Experience with nontreatment of central serous choroidopathy.


Bimedial recession in high AC/A esotropia. A long-term follow-up.


Choroidal detachment associated with primary retinal detachment.


Improvements in the diagnosis of posterior uveal melanomas.


Cystinosis. A clinical, histopathologic, and ultrastructural study.


Infections with the therapeutic soft lens.


Fibroma of the cornea. Report of a case associated with congenital generalized fibromatosis.


Epithelialization of the anterior chamber. A complication of prosthokeratoplasty.


Histoplasma capsulatum in human ocular tissue.


Repair of drooping brow and upper eyelid. Correction of defects secondary to facial nerve palsy.


Limbal peritomy in retinal detachment surgery.


Dose-response of cholinergic agonists on cat irides.


Experimental immunogenic orbital inflammation.


Capillaries of rat optic nerve. Relationship of anomalies to cyanide lesions.


Vitreous surgery. XI. A scleral supporter for vitreous surgery.


Cyst of the posterior vitreous.

Cyst of the posterior vitreous.


Retinal medullated nerve fibers.

Retinal medullated nerve fibers.


Werner syndrome disputed.

Werner syndrome disputed.


Preoperative assessment for anaesthesia.


Acute adrenal insufficiency during surgery. A case report.


Pentazocine and intraocular pressure in paediatrics.


The inadvertent continuous spinal continued.


Crisis.

Crisis.


Effect of acute hypovolaemia on lignocaine absorption and cardiovascular response following epidural block in dogs.


Inhalation anaesthetics and their interaction in vitro with glutamate dehydrogenase and other enzymes.


The effect of ketamine on transmembrane potentials of Purkinjé fibres of the pig heart.


Effects of halothane on DNA synthesis and mitosis in root tip meristems of Vicia faba.


Initial studies in man with a new myoneural blocking agent (ORG.6368).


The strange case of the (inadvertent) continuous spinal.


A non-invasive technique of comparing myocardial performance following epidural blockade and vasopressor therapy.


Cerebral blood flow and metabolism during hypotension induced with sodium nitroprusside.


A comparison of althesin and methohexitone in paediatric anaesthesia.


An assessment of althesin for the induction of anaesthesia in cardiac surgical patients: a comparison with thiopentone.


A new blood warmer.

A new blood warmer.


Bronchial rupture associated with flail chest treated by external traction.


Ketamine in the management of a case of lymphosarcoma cutis.


Bacteriological filters for strain gauges.


Increased toxicity of althesin in newborn animals.


Malignant hyperpyrexia caused by trimeprazine.


Biochemical blood studies in patients with carcinoma of the ovaries during treatment with preparation C-283. II. Behavior of seromucoid and its electrophoretic fractions.


The influence of LH on synthesis of RNA, DNA, proteins and lipids and content of ascorbic acid and cholesterol in the luteinized rat ovary.


Morphology of bacteriophages of Klebsiella bacilli.


Local anaesthesia.

Local anaesthesia.


Some effects of enflurane anaesthesia on biogenic monoamines in the brain and plasma of rats.


Incidental hypothermia during surgery for peripheral vascular disease.


Persistent electroencephalographic alterations following administration of some volatile anaesthetics.


Blood viscosity and open heart surgery. A comparison of values in systemic and pulmonary blood vessels.


The effect of methohexitone on myocardial blood flow and oxygen consumption in the dog.


The effect of ventilation system design on air contamination with halothane in operating theatres.


Mitogen-induced lymphocyte transformation after general anaesthesia.


When does blood haemolyse? A temperature study.


Epidural analgesia for the surgical induction of labour.


Pulmonary complications after 154 trans-thoracic operations requiring more than 8 hours anaesthesia.


Further observations on the effects of general anaesthesia on intraocular pressure in man: halothane in nitrous oxide and oxygen.


Facial vasomotor behaviour.

Facial vasomotor behaviour.


Clinical anaesthesia and the multiple-gauze condenser-humidifier.


Arrhythmia and oral surgery: induction of anaesthesia with althesin.


The effects of methylphenidate on postoperative pain and vasoconstriction.


Atropine toxicity in a neonate.

Atropine toxicity in a neonate.


Severe metabolic acidosis following hypotension induced with sodium nitroprusside. Case report.


Plasma levels of diazepam after oral and intramuscular administration.


Changes in canine myocardial blood flow and oxygen consumption in response to halothane.


The long-term safety of methoxyflurane analgesia during labour.


Feed-back monitoring in anaesthesia. III: The control of halothane administration by respiratory patterns.


Mechanical stability of serum cholinesterase.


Bupivacaine 0.125% in epidural block analgesia during childbirth: clinical evaluation.


Ionized calcium in acidosis: differential effect of hypercapnic and lactic acidosis.


Humidification and loss of body heat during anaesthesia. I: Quantification and correlation in the dog.


The effect of nitrous oxide and halothane upon the intracranial pressure in hypocapnic patients with intracranial disorders.


Humidification and loss of body heat during anaesthesia. II: Effects in surgical patients.


Changes in visual reaction time following cerebral angiography. Preliminary communication.


Adrenocortical response to major surgery and anaesthesia in elderly patients.


Althesin in outpatient dental anaesthesia.


An assessment of three electronic respirometers.


Post-traumatic respiratory distress due to endotoxinaemia and intravascular coagulation.


Anaesthetic management of "prune belly" syndrome. Case report.


A device for maintaining anaesthesia during fibreoptic bronchoscopy.


Relationship between suxamethonium apnoea, serum cholinesterase activity and inhibitor numbers.


Comparison of the effects of althesin and barbiturates on the neocortex and hippocampus in cats.


Immediate changes in plasma potassium, sodium and chloride induced by intravenous induction agents.


Effects of bitemporal electrical stimulation on the duration of suxamethonium apnoea in man.


Dangerous fault in disposable connector for orotracheal tube.


Bupivacaine 0.125% in epidural block analgesia during childbirth: maternal and foetal plasma concentrations.


Toxicity of sodium nitroprusside.

Toxicity of sodium nitroprusside.


A method of ventilation with Entonox during bronchoscopy.


Denticare, dentures and prevention all part of the dentistry forum. Toronto Star forum on dental care hears views of profession and public.


Anaesthesia for emergency coronary artery surgery.


Dentist--M.P.P. says he will lend a qualified support to the denturists.


Mobile dental units now operated by Ontario Ministry of Health.


Potential hazards of asbestos in periodontal packs.


Basic principles of four handed sit down dentistry and effective utilization of a chairside dental assistant.


Repair of DNA in mammalian cells.

Repair of DNA in mammalian cells.


Controls of citrate synthase activity.

Controls of citrate synthase activity.


Inhibitors of immune reactions.

Inhibitors of immune reactions.


Selective immunodepression.

Selective immunodepression.


Postreplication repair of DNA in mammalian cells.


Somatostatin inhibits insulin and glucagon release by monolayer cell cultures of rat endocrine pancreas.


The biochemical basis of learning and memory.


Substance P.

Substance P.


Relation of sex and occlusion to mesiodistal tooth size.


Oral hygiene for orthodontic patients: current concepts and practical advice.


The etiology of the temporomandibular joint dysfunction syndrome.


Pattern commonality in the facial orientation of the occlusal region: form-functional significance and clinical potentiality.


Activators: a practical approach.

Activators: a practical approach.


'The Early Diagnosis of the Acute Abdomen'.


Rupture of left ventricle from blunt cardiac trauma. Report of a survivor and review of the literature.


Dissecting aortic aneurysms.

Dissecting aortic aneurysms.


Nonsuppurative otitis media in myasthenia gravis.


Tracheostomy. Complications and their management.


Endoscopic retrograde choledocho-pancreatography. A review with a report of a collaborative series.


A randomized study on survival of bronchogenic carcinoma treated with conventional or short fractionation radiation.


Reticulum-cell sarcoma of host origin arising in a transplanted kidney.


Glomerular sclerosis in adults with nephrotic syndrome.


Skin immunofluorescence studies on lupus erythematosus and other antinuclear-antibody-positive diseases.


Schmidt's syndrome presenting as hypopituitarism.


Bacteremia after the use of an oral irrigation device. A controlled study in subjects with normal-appearing gingiva: comparison with use of toothbrush.


Erosive syphilitic gastritis: dark-field and immunofluorescent diagnosis from biopsy specimen.


Digitalis pharmacology and therapeutics: recent advances.


Prinzmetal's angina: atropine suppression.


Cyclophosphamide: use in practice.

Cyclophosphamide: use in practice.


References: needed and unneeded.

References: needed and unneeded.


The identification of labelled structures on autoradiographs.


Maturation of ribosomal RNA.

Maturation of ribosomal RNA.


Role of ATP in DNA replication.

Role of ATP in DNA replication.


Positional information in chick limb morphogenesis.


Periodic geophysical and biological signals as Zeitgeber and exogenous inducers in animal organisms.


Telemetry in biometeorological studies. Telemetry in animal biometeorology.


Effects of atmospheric and extra-terrestrial electromagnetic and corpuscular radiations on living organisms.


Telemetry and wildlife control.

Telemetry and wildlife control.


Effects of natural and artificially generated air ions on mammals.


Possible effects of extra-terrestrial stimuli on colloidal systems and living organisms.


The significance of biological rhythms in biometeorology. Biological rhythms and human biometeorology, with special reference to mortality rhythms and chronotoxicology.


Permeability of the cornea to topically applied drugs.


Respiratory aspects of the preoperative examination.


Cardiological aspects of the preoperative examination.


The preoperative chest X-ray.

The preoperative chest X-ray.


Biochemical screening tests for the anaesthetist.


The incidence of medical disease in surgical patients.


Anaesthesia and the hypertensive patient.


Anaemia and anaesthesia.

Anaemia and anaesthesia.


Neuromuscular disease and anaesthesia.

Neuromuscular disease and anaesthesia.


Drug interactions in anaesthesia.

Drug interactions in anaesthesia.


Anaesthesia and medical disorders: selected references.


Residual nerve block following intravenous regional anaesthesia.


Some effects of maintaining pulmonary nitrogenation during anaesthesia.


Phage typing of Shigella flexneri.

Phage typing of Shigella flexneri.


Method of obtaining plaque-forming phage X of Shigella flexneri.


Serologic analysis of Lac+ recombinants of E. coli HfrC and Shigella flexneri 2A.


Changes in antigenic structure of S. flexneri 1a as a result of genetic recombination with E. coli.


Morphology of bacteriophages of E. Hammarström's set for typing Shigella sonnei.


Variations of sensitivity of Shigella flexneri bacilli to bacteriophages as a result of recombination.


Cardiac rhythm in dental anaesthesia: a comparison of five anaesthetic techniques.


Information retrieval systems: a guide.

Information retrieval systems: a guide.


The effects of sodium nitroprusside on myocardial contractility and haemodynamics.


The effects of cuffed endotracheal tubes on the tracheal wall.


A clinical trial of Ro5-4200 (flunitrazepam) used to supplement spinal anaesthesia in elderly patients.


Metabolic response to anaesthesia and upper abdominal surgery in Nigerians: changes in plasma cortisol, insulin and blood sugar.


Skills related to driving after intravenous diazepam, flunitrazepam or droperidol.


O.D.A. executive is shown a new prosthetic concept.


Computer can be used for orthodontic diagnosis.


Morphology, growth and orthodontic treatment.


Periodontal therapy. I. Radiographic interpretation. Periodontal therapy. II. Radiographic technique.


Relation between the number of myelin lamellae and axon circumference in fibres of ventral and dorsal roots and optic nerve in normal, undernourished, and rehabilitated rats. An ultrastructural morphometric study.


Physical properties of connective tissue as influenced by single and repeated pregnancies in the rat.


Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise.


Professional nursing practice in acute care settings.


National health insurance--implications for nursing.


Licensed practical nurses in nursing service.


State-approved schools of nursing---L.P.N./L.V.N. meeting minimum requirements set by law and board rules in the various jurisdictions.


One agency's experience with group practice.


Extending the scope of nursing practice.


Profile of an experimental nursing curriculum at Cuesta College.


Associated degree education for nursing.


Communicate, or else.

Communicate, or else.


An experiment in open curriculum.

An experiment in open curriculum.


Implications of SASHEP for AAJC and NLN.


Neglected dimensions of leadership.

Neglected dimensions of leadership.


Homemakers in the home and in the community health agency.


State organization highlights--bi-state community health project.


Preparation of the nurse practitioner at the baccalaureate level.


Response to "Preparation of the nurse practitioner at the baccalaureate level".


Issues for the Black nurse today: competence and commitment.


The role and responsibility of the chief administrative officer of a hospital in planning and implementing a budget for a school of nursing.


The health profession educational organization and the governmental process.


Evanston Hospital Open Curriculum project. Evanston Hospital School of Nursing; Evanston, Illinois..


Integrating the unique nursing student and faculty.


The nature and destiny of non-traditional study.


The problem-oriented system in home health agencies.


Forensic examination by the dentist.

Forensic examination by the dentist.


The sign of the cross in nursing insignia.


Class of 1973 Graduation Address, June 16, 1973.


Being a clinical nurse specialist.

Being a clinical nurse specialist.


Nursing orders.

Nursing orders.


Scholarship in nursing: an unpopular subject.


Demonstration of candida in blood smears.


Interaction of thyrotropin releasing factor with membrane receptors of pituitary cells.


The cleavage of DNA by the oxygen-dependent reaction of bisulfite.


Alkaline phosphatase derepression in vegetative cells of Bacillus subtilis by glucose and its reversal by lactate.


A phage-mutant directed synthesis of a fragment of diptheria toxin protein.


Correlation between fiber length, ultrastructure, and the length-tension relationship of mammalian smooth muscle. The length-tension relationship was determined for strips of guinea pig taenia coli and correlated with the length and ultrastructural organization of the component fibers. The mean fiber length in "stretched" strips (passive >/= active tension) was 30% greater than that for fibers in "unstretched" strips (active >> passive tension). In stretched fibers the dense bodies and 100 A diameter myofilaments were consolidated into a mass near the center of fibers in cross-sectional profile. The thick myofilaments were segregated into the periphery of the fiber profiles. In unstretched fibers the dense bodies-100 A diameter filaments and the thick myofilaments were uniformly distributed throughout cross-sectional profiles. A tentative model is proposed to account for the change in fiber length and ultrastructural organization that accompanies stretch. The basic features of the model require the dense bodies to be linked together into a network by the 100 A diameter filaments. The functional consequences of stretching the fibers are discussed in relation to the model proposed for this network.


37RC cells rapidly recover their RNA synthesis after inhibition with high doses of actinomycin D.


Peroxidase diffusion in the normal and laser-coagulated primate retina.


Retinal traction in vitro. Biophysical aspects.


Acute leukemia following cytotoxic chemotherapy.


Primary gonococcal stomatitis.

Primary gonococcal stomatitis.


Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal.


Formation of the periodontal ligament.

Formation of the periodontal ligament.


Experiments on the development of dental malocclusions.


Quantitative determination of the human immune response to immunization with meningococcal vaccines. Radioactive antigen binding tests have been developed to measure quantitatively the antibody response of 167 adults, 84 children, and 51 infants to several different preparations of group A and group C meningococcal polysaccharides. Almost all the adults injected responded and the geometric mean responses were approximately 15 mug/ml of antibody protein in individuals vaccinated subcutaneously with two preparations of group A vaccine. The geometric mean antibody concentration after immunization with two preparations of group C vaccine was approximately 35 mug/ml. Most children aged 7 yr responded to immunization with two group A vaccines, and their mean response was only slightly less than that seen in adults. There was no difference between the subcutaneous and the intradermal route if both were given with jet gun. The majority of infants aged 6-13 months responded to a preparation of group A vaccine and the geometric mean titer was approximately 1.2 mug/ml. Adults, children, and infants responded significantly less to a preparation of group A polysaccharide which was of low molceular weight.


Prophylaxis in rheumatic fever.

Prophylaxis in rheumatic fever.


Hypothalamic releasing hormones.

Hypothalamic releasing hormones.


Carcinoembryonic antigen in faeces.

Carcinoembryonic antigen in faeces. Carcinoembryonic antigen (C.E.A.) was detected in the faeces of 5 out of 10 healthy volunteers, 12 out of 18 patients suffering from gastrointestinal cancer (including 10 out of 11 cases of colonic cancer), and 3 out of 13 patients suffering from non-neoplastic disease. It is suggested that C.E.A. may be present in small amounts in normal faeces but that in malignant conditions of the bowel the amount increases.


Synthesis and antibacterial activity of 5-nitro-2-furfurylidene arylthioacethydrazides and 5-nitro-2-furfurylidene arylsulfonylacethydrazides.


Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children. We have used precipitin tests to detect antibodies to 10 dietary proteins in the serum (71 cases) and intestinal secretions (51 cases) of a group of children. Thirty-three of the patients had untreated coeliac disease. Our aims were to find out if, in coeliac patients, there was intestinal secretion of antibodies to wheat proteins only or if, as in coeliac serum, antibodies to many food proteins were present; and to confirm that secretion of antibodies to wheat or gluten was specific for coeliac disease.Precipitins to one or more dietary antigens were detected in the intestinal secretions of 26 out of 30 coeliacs and of 11 out of 21 children who did not have coeliac disease. Most of the positive reactions were with the antigens wheat flour, gluten, oatmeal, and egg. Though precipitins to wheat flour or gluten were present in the intestinal secretions of 22 out of 30 coeliacs this was not specific for coeliac disease for these precipitins were also present in 8 out of 21 non-coeliac children.Serum precipitins were detected in 27 out of 33 coeliacs (to the antigens wheat flour, gluten, oatmeal, rice flour, milk, bovine calf serum, sheep serum, and egg) and in 5 out of 33 non-coeliacs (mainly to milk and calf serum, but two infants aged 3 and 5 months had precipitins to several antigens).


Antibacterial activity of 0-amino-N-hydroxybenzenesulfonamides.


Synthesis of di- and tripeptides and assay in vivo for activity in the thyrotropin releasing hormone and the luteinizing releasing hormone systems.


N-Carbalkoxy-O-alkylalkanamidoximes. A new series of insecticides.


Proteinase-dependent false positive precipitin tests.


Prognosis in childhood epilepsy. Follow-up study of 148 cases in which therapy had been suspended after prolonged anticonvulsant control.


Technics of HAA detection.

Technics of HAA detection.


Lateral alveolo-maxillary osteotomies. Revascularization studies.


Biochemical characterization and skin test sensitivity of mycelial growth filtrate of Histoplasma duboisii.


Chin augmentation with polytef paste injection.


Hyperalimentation without sepsis.

Hyperalimentation without sepsis.


Health maintenance organizations and pharmaceutical services.


The repair of fractures of the orbital floor using biodegradable polylactic acid.


The effects of prostaglandins E 1 , A 1 , and F 2a  on the cerebral circulation of dogs and monkeys.


Craniocerebral missile injuries in the monkey: an experimental physiological model.


Experimental effect of intracranial hypertension upon intraocular pressure.


The function of platelets in hemostasis.


Observations on the fate of blood in the anterior chamber. A light and electron microscopic study of the monkey trabecular meshwork.


Atypical Pseudomonas corneal ulcers in semicomatose patients.


Effects of topical Thio-TEPA on rat eyes.


Effect of rifampicin on Proteus keratitis.


Anomalies with ring D chromosome.

Anomalies with ring D chromosome.


The clump cells of Koganei. A light and electron microscopic study.


Incidence of isolated deficiency of IgA in the serum of Canadian children.


Joint reactions in children vaccinated against rubella. II. Comparison of three vaccines.


Cross-protection studies and search for subclinical disease in new world monkeys infected sequentially with different immunologic types of Dengue viruses.


Antigenic comparison of Rauscher murine leukemia virus cultivated in human embryo and mouse cells.


The effects of pregnancy on biliary lipids in rhesus monkeys.


Hemadsorption by coronavirus strain OC43.


Red cell membrane antigens common to several mammalian species.


Continuous long-term replication of feline leukemia virus (FeLV) in an established canine cell culture (MDCK).


The influence of the thyroid on the acute toxicity of a dynamite-sensitizing mixture.


IgM, not 7S-IgM, as cause of increased serum IgM concentrations in goiter patients.


On the mechanism of action of phytohemagglutinin in cellular immunity.


The uterine cervix in mammals.

The uterine cervix in mammals.


Observations on candidal vaginitis. Vaginal pH, microbiology, and cytology.


Manual and automated determination of immunoglobulins in unconcentrated cerebrospinal fluid.


Preparation of vaccines for Rocky Mountain spotted fever from rickettsiae propagated in cell culture.


Anti-Candida factors in serum and their inhibitors. I. Clinical and laboratory observations.


Effects of the combination of gentamicin and carbenicillin on the bactericidal activity of serum.


Pseudomonas aeruginosa in a center for cancer research. I. Distribution of intraspecies types from human and environmental sources.


Type-specific immunity in pseudomonas diseases.


Characterization and pathophysiology of serum glycoprotein alterations in malaria.


Regional brain blood flow and carbon dioxide tension in the halothane-anesthetized rhesus monkey.


Effect of intra-articular hydrocortisone on complement in synovial fluid.


Burning sensation and potency of nitroglycerin sublingually.


The effect of lithocholic acid on red cell membranes in vivo.


Parenteral hyperalimentation in anorexia nervosa.


Contingent negative variation (CNV) and psychological processes in man.


Urinary aflatoxin B and effects of preservatives on its detecton.


Metabolic aspects of caloric restriction (420 kcal): body composition changes.


Immunoglobulins in the bronchial washings of patients with chronic obstructive pulmonary disease.


Failure to produce experimental sarcoidosis in guinea pigs with Mycobacterium tuberculosis and mycobacteriophage DS6A.


Long-term continuous exposure to sulfur dioxide in cynomolgus monkeys.


DNA synthesis in rat liver during early stages of azo dye-induced hepatocarcinogenesis.


A rapid determination of thyroxine-binding globulin in human serum by means of the Laurell rocket immunoelectrophoresis.


Gel electrophoresis for assessing fibrin crosslinking: a precaution.


A simplified tetracycline assay.

A simplified tetracycline assay.


A new unified Biuret reagent stabilized with EDNA.


Activity of redd cell glutamic oxalacetic transaminase in epileptic children under antiepileptic treatment.


Measurements of concentrations of human serum immunoglobulins.


The quantification of an acid stable esterase in human gastric juice by single linear immunodiffusion.


Reflections on the treatment of headache.


The effects of digit sucking on facial growth.


Radiation therapy in selected ovarian cancers. A negative report.


Parenteral hyperalimentation for children.


Sometimes forgotten tax deductibles.

Sometimes forgotten tax deductibles.


Exchangeable and total body potassium in patients with chronic renal failure. Total body potassium determined by whole-body monitoring and exchangeable body potassium estimated with (43)K were measured simultaneously in 12 patients with stable chronic renal failure. Values for the exchangeable potassium were obtained after equilibration periods of 24, 48, and 64 hours. The exchangeable body potassium, expressed as a percentage of the total body potassium (mean +/- S.E. of mean), gave values of 60.7 +/- 3.3%, 83.6 +/- 2.7%, and 85.9 +/- 2.7% at 24, 48, and 64 hours respectively. It seems that the equilibration between radioactive and native potassium is incomplete after 24 hours; and that exchangeable potassium measured at this time is not an accurate index of the status of total body potassium in such patients. Furthermore, the finding that the value at 64 hours is significantly less than found in healthy subjects suggests that the exchangeable potassium is a smaller fraction of the total body potassium in patients with chronic renal failure.


Specimens from female genital tract.

Specimens from female genital tract.


Long-term measurement of pulsatile blood pressure and ECG in the squirrel monkey.


Studies on the control of whirling disease (Myxosoma cerebralis). I. The effects of chemicals on spores in vitro, and of calcium oxide as a disinfectant in simulated ponds.


Unsuccessful attempts to establish cattle Babesia infections in white-tailed deer.


Health Maintenance Organizations.

Health Maintenance Organizations.


67 Ga for tumor scanning.

67 Ga for tumor scanning.


Estimation of the T 4  binding capacity of serum TBG and TBPA by a single T 4  load ion exchange resin method.


A "kit" method for the preparation of a technetium-tin(II) colloid and a study of its properties.


Comparison of analytic methods for calculation of cerebral blood flow after intracarotid injection of  133 Xe.


A survey of hospital-sponsored long-term care units aided by Hill-Burton funds.


Treatment of gonorrhea. Penicillin or tetracyclines?


Use of jet insulin injection in diabetes mellitus therapy.


Measles virus antibody in cerebrospinal fluids from patients with multiple sclerosis. A strong measles-specific gel precipitation reaction was found in the cerebrospinal fluid (C.S.F.) of two patients with multiple sclerosis (M.S.) (total of 15 tested). The serum and C.S.F. specimens from these two patients were tested for measles antibody by six assay methods. The results were compared with those obtained from serum and C.S.F. specimens of a patient with subacute sclerosing panencephalitis (S.S.P.E.). The gel precipitation line produced by the C.S.F. from the M.S. patients was identical with one of the three lines produced by the C.S.F. from the S.S.P.E. patient. The main antigenic component responsible for measles antibody appearing in the C.S.F. of the S.S.P.E. patient and the M.S. patients was also electrophoretically similar, and the corresponding antibody was associated with IgG. The serum/C.S.F. antibody titre ratios with the various assay methods used suggest that the C.S.F. antibodies are mainly to other than envelope components of measles virus. No complement-fixing antibody against 27 other viruses or Mycoplasma pneumoniae was found in the C.S.F. of the two M.S. patients.


A congenital diverticulum of lacrymal sac successfully operated.


85 Sr lung scan in a case of pulmonary ossification.


Epiphrenic diverticula of the esophagus. Certain considerations about its surgical treatment.


Importance of proper bowel cleansing before 131-I whole-body scan or retention study.


Carcinoma of the cervical esophagus.

Carcinoma of the cervical esophagus.


Depth dose and scatter analysis of 10 MV X rays.


Radioligand-receptor assay of luteinizing hormone and chorionic gonadotropin.


The influence of liver damage in man on the distribution and disposal rates of thyroxine and triiodothyronine.


The spectrum of hypoparathyroidism.

The spectrum of hypoparathyroidism.


Effects of a new hypolipidemic agents, MK-185, on serum thyroxine-binding globulin (TBG) and dialyzable fraction thyroxine.


Synthesis and biological activity of 4'-thio analogs of the antibiotic toyocamycin.


Synthesis and antimicrobial activity of a carbocyclic puromycin analog. 6-Dimethylamino-9-(R(2R-hydroxy-3R-(p-methoxyphenyl-L alanylamino))-cyclopentyl)purine.


Hepatocarcinogenicity of the trimethyl homologs of 4-dimethylaminazobenzene.


Rhesus sensitization in abortion.

Rhesus sensitization in abortion.


Protective effects of bile diversion to the distal fourth of small intestine against experimental hypercholesterolemia and atherosclerosis in dogs.


The role of prefrontal cortex in grand mal convulsion.


Experimental ammonia encephalopathy in the primate.


Unilateral pyramidotomy in monkeys: effect on force and speed of a conditioned precision grip.


Electron microscopic studies of human monocyte and lymphocyte interaction with immunoglobulin- and complement-coated erythrocytes.


Experimental brain prosthesis for stroke.


Effects of ethidium bromide on growth and morphology of Tetrahymena pyriformis.


Whole mount electron microscopy of salivary gland chromosomes after treatment with alkaliurea.


Genetic and chromosomal abnormalities in early infancy.


Copper on intrauterine devices stimulates leukocyte exudation. Metallic copper in the uterine or abdominal cavities of rats or monkeys stimulates an impressive local exudation of polymorphonuclear leukocytes. This cellular response to copper persists for at least 7 months, without significant local tissue damage or detectable systemic effects on the test animal. This finding provides a possible explanation for the capacity of copper to increase impressively the antifertility effect of polyethylene intrauterine contraceptive devices.


Polychlorinated biphenyls: toxicity to certain phytoplankters. The growth rates of two species of marine diatoms were reduced by polychlorinated biphenyls (PCB's), widespread pollutants of the marine environment, at concentrations as low as 10 to 25 parts per billion. In contrast, a marine green alga and two species of freshwater algae were not inhibited at these or higher concentrations. The sensitivity of these species to PCB's paralleled their sensitivity to DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane].


Auditory cortex of squirrel monkey: response patterns of single cells to species-specific vocalizations. Most of the neurons tested in the superior temporal cortex of awake squirrel monkeys responded to recorded species-specific vocalizations. Some cells responded with temporally complex patterns to many vocalizations. Other cells responded with simpler patterns to only one call. Most cells lay between these two extremes. On-line deletion of parts of a vocalization revealed the role of temporal interactions in determining the nature of some responses.


Thyrotropin-releasing hormone: evidence for thyroid response to intravenous injection in man. Administration of thyrotropin-releasing hormone to normal subjects causes a prompt rise in plasma thyrotropin concentration, followed by a significant increase in circulating plasma triiodothyronine. These observations may prove to be of value in simultaneously assessing the ability of the pituitary and thyroid glands to respond to their trophic hormones.


Uterine vascular bed: initial conductance and maximal vasodilator response.


Effects of adrenalectomy on pregnancy length in the rhesus monkey.


Sodium, potassium, and magnesium concentrations in the enamel and dentin of human and rhesus monkey teeth.


Two patterns of perinatal brain damage and their conditions of occurrence.


Corynebacterium acnes in rheumatoid arthritis. II. Identification of antigen in synovial fluid leucocytes.


Corynebacterium acnes in rheumatoid arthritis. I. Isolation and antibody studies.


Relative effectiveness of certain chemosterilizers on selected microbial species.


Diverticulum of the vermiform appendix. A review of 28 cases. Twenty-eight previously unreported cases of appendiceal diverticula were found in a 15-year retrospective review of records at five hospitals. The incidence is probably higher than is realized. Data drawn from the review indicated that the age of the patient and a history of previous attacks might be slight clues to distinguishing between diverticulum and acute appendicitis. Inflamed or not, rarely are these diverticula recognizable at the time of operation, but if the appendix is bulbous or club-shaped or there is increased thickening of the mesentery, the surgeon's suspicion should be aroused. In four of fourteen acute cases in the series, perforation had occurred-within 15 hours of the onset of symptoms in two cases. In four others there was abscess formation within the mesentery of the appendix.


Diagnostic effectiveness of electrophoresis and specific protein assays, evaluated by discriminate analysis.


The oxygen-transporting system in relation to age.


Membrane reorganization during secretion in Tetrahymena.


Persistence of viruses of kuru and Creutzfeldt-Jakob disease in tissue cultures of brain cells.


The sweet tooth.

The sweet tooth.


Virus satellite plaques.

Virus satellite plaques.


Excitation and fluorescence spectra of the chromophore associated with the DNA-photoreactivating enzyme from the blue-green alga Anacystis nidulans.


Gametogony of Sarcocystis sp. in cell culture. Sexual stages and cystlike bodies of Sarcocystis sp., a protozoan parasite found in muscles of reptiles, birds, and mammals, including man, developed in cell culture. Motile organisms, obtained from leg muscles of wild grackles, were inoculated into cell line cultures of embryonic bovine kidney. Mature micro-and macrogametes and the cystlike forms were found 30 and 42 hours after inoculation respectively. These observations indicate that the parasite is probably a coccidium.


Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins. The isolation of a new type of mutant Corynephage beta, which carries a missense mutation in the structural gene for diphtheria toxin synthesis is described. The lysogenic C7(8)(beta(197))(tox-crm+) strain of Corynebacterium diphtheriae produces a nontoxic, extracellular protein of molecular weight 62,000. This protein is immunologically indistinguishable from toxin itself but inhibits the action of toxin on HeLa cells, probably by competing for attachment sites on the cell membrane. In contrast to fragment A derived from diphtheria toxin, fragment A(197) is unable to catalyze the inactivation of eucaryotic polypeptidyl-transfer RNA-transferase II. When mixtures of the two nontoxic mutant proteins, enzymically active crm(45) protein and enzymically inactive crm(197) protein, are subjected to mild treatment with trypsin in the presence of a thiol and then allowed to reoxidize after dialysis to remove excess thiol, "diphtheria toxin" is reconstituted in high yield.


Deflation in an inflationary period: some current social health need provisions.


Measurement of serum IgE by a one-step single radial radiodiffusion method.


Immunologic cross-reactions of thermophilic actinomycetes isolated from home environments.


Increased antibodies to IgG fragments: correlation with infection due to gram-positive bacteria.


Excretion of aflatoxin by frogs after implantation with Aspergillus flavus.


Delayed hypersensitivity to hepatitis-associated antigen in guinea pigs.


Detection thresholds for stimuli in humans and monkeys: comparison with threshold events in mechanoreceptive afferent nerve fibers innervating the monkey hand.


Visual properties of neurons in inferotemporal cortex of the Macaque.


Graded cryohypophysectomy in the rhesus monkey. Histopathology and endocrine function.


The properties of IgM-L pyroglobulin.

The properties of IgM-L pyroglobulin.


Disc-electrophoretic patterns of human serum high density lipoproteins.


A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes.


Red cell acetylcholinesterase deficiency in ABO hemolytic disease of the newborn.


Bisalbuminemia associated with albumin dye binding defect.


Immunologic responses to Hemophilus influenzae meningitis.


Intramural diverticulosis of the esophagus: report of a case in a child.


Fine structure of the surface and infraciliature of Gastrostyla steinii.


A new species of Henneguya (Myxosporidea: Myxobolidae) from the black drum Pogonias cromis in Clear Lake, Texas.


An ultrastructural comparison of Euglena gracilis Klebs, bleached Euglena and Astasia longa Pringsheim.


The action of mercaptoethanol on cell division in synchronized Tetrahymena.


Revision of the order Hypotrichida (Ciliophora, Protozoa).


Rapid scanning microspectrophotometry of colorless Euglena gracilis and Astasia longa. A basis for differentiation.


Sarcocystis in tortoises: a replacement name, Sarcocystis kinosterni, for the homonym Sarcocystis gracilis Lainson & Shaw, 1971.


Observations on the fine structure of the schizonts of Haemoproteus columbae Kruse.


Proline metabolism in Tetrahymena.

Proline metabolism in Tetrahymena.


Ultrastructural study of gametocytes and gametogenesis of Haemoproteus metchnikovi.


Serologic changes associated with the encystment of axenically grown Hartmannella culbertsoni.


Changes in individual plasma amino acids following experimentally induced and fly fever virus infection.


Use of a desk-top computer as a decision maker for exchange transfusion of newborns.


Pyocine typing of Pseudomonas aeruginosa: clinical and epidemiologic aspects.


Evaluation of single radial immunodiffusion for quantitation of plasma fibrinogen.


In vitro incorporation of (1- 14 C)leucine into rat liver microsomal protein after dietary supplementation with 3'methyl-4-dimethylaminoazobenzene, chloramphenicol or both compounds.


Early stage in the metabolism of aminoazo dyes in the liver of rats.


Prevention by chloramphenicol of suppressed hepatic azo reductase activity due to 3'-methyl-4-dimethylaminoazobenzene.


Alterations in turnover of labelled precursors incorporated into rat liver nuclear macromolecules during azo dye feeding.


An increase in death rate of Anopheles stephensi fed on rabbits immunized with mosquito antigen.


The scanning electron microscope.

The scanning electron microscope.


Cellular receptors for PHA and antigen-induced transformation of peripheral blood and thoracic duct lymphocytes.


Effect of progesterone and estradiol on LH release and ovulation in Rhesus monkeys.


Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease.


Failure of a single neonatal dose of testosterone to alter ovarian function in the Rhesus monkey.


Protein binding of cortisol in the Rhesus monkey (Macaca Mulatta).


On the nature of the initial luteotropic stimulus of pregnancy in the Rhesus monkey.


Find deprived cells a major cause of blindness.


The influence of the carbonic anhydrase inhibitor, benzolamide (CL-11,366), on the reabsorption of chloride, sodium, and bicarbonate in the proximal tubule of the rat. Benzolamide (CL-11,366), a potent carbonic anhydrase inhibitor, was used to examine the influence of carbonic anhydrase inhibition on the reabsorption of chloride, sodium, and bicarbonate in the rat proximal convoluted tubule. Administration of 2 mg/kg benzolamide was associated with a decrease in the tubular fluid/plasma (TF/P) chloride ratio from 1.19+/-0.10 (SEM) to 1.06+/-0.01, and an increase in the TF/P bicarbonate ratio from 0.181+/-0.02 to 0.584+/-0.02. This dose of benzolamide significantly reduced proximal fractional reabsorption of chloride by 29.14%, of sodium by 34.3%, and of bicarbonate by 35.64%. These results indicate that benzolamide administration inhibits the reabsorption of all three electrolytes in the proximal convoluted tubule. Although 20 mg/kg benzolamide accentuated the changes in fractional reabsorption, the differences between 2 and 20 mg/kg were not statistically significant. Inhibition of proximal tubular cytoplasmic and luminal carbonic anhydrase could well explain the diminished bicarbonate reabsorption and a fraction of the diminished sodium reabsorption noted in these studies. The fall in chloride reabsorption, and a portion of the fall in sodium reabsorption, however, may be a direct or indirect consequence of carbonic anhydrase inhibition or of an influence of benzolamide on a transport mechanism not dependent upon carbonic anhydrase.


Serum thyrotropin responses to synthetic thyrotropin-releasing hormone in normal children and hypopituitary patients. A new test to distinguish primary releasing hormone deficiency from primary pituitary hormone deficiency. Synthetic thyrotropin-releasing hormone (TRH) was administered intravenously in a dose of 7 mug/kg to 20 normal children ages 4-13 yr. Serum thyroid-stimulating hormone (TSH) was measured by radioimmunoassay and rose from a mean value of 1.7 muU/ml (range = < 1.25-7.2) to a mean peak value of 21.5 muU/ml (5.2-33.2) at 15 or 30 min after administration.13 patients with idiopathic hypopituitarism and apparent normal thyroid function, ages 3-19 yr, responded to TRH in a manner very similar to the control subjects: TSH rose from a mean value of 1.8 muU/ml (range < 1.25-4.3) to a mean peak value of 18.5 muU/ml (range = 9.5-45.0) which occurred between 15 and 60 min after TRH.13 idiopathic hypopituitary patients with documented thyroid deficiency were tested after thyroid therapy had been discontinued for a minimum of 10 days. The serum TSH values in 10 of 13 patients rose from a mean base line level of 2.2 muU/ml (< 1.25-5.3) to a peak mean value of 32.5 muU/ml (9.6-61.3) between 30 and 120 min after TRH. In three patients, however, little or no TSH response was detected, even when serum thyroxine levels were extremely low. Similar to the latter group, three of five patients with hypopituitarism secondary to craniopharyngiomas had undetectable or barely measurable TSH levels before and after TRH. Two of these five patients had significant responses which were compatible with hypopituitarism resulting from damage to the hypothalamus or hypothalamic vessels instead of the pituitary. Side effects were experienced in 41 of 54 patients (76%). The effects were limited to a mild nausea-like sensation in 63% of the patients and occurred within the first 5 min after receiving TRH. No evidence of serious toxicity or long-term side effects was noted. The TRH test is a safe, effective way to measure TSH reserve in children. The positive response in 10 of 13 patients with secondary hypothyroidism supports data previously accumulated that most patients with idiopathic hypopituitarism have an abnormality of their hypothalamic-releasing hormone function, whereas the remaining minority probably have primary pituitary disease.


Korsakoff's syndrome associated with surgical lesions involving the mammillary bodies.


Carbon dioxide hydration activity of carbonic anhydrase: kinetics of alkylated anhydrases B and C from humans (metalloenzymes-isoenzymes-active sites-mechanism). A stop-flow kinetic study was performed on the carbon dioxide hydration activity of the human carbonic anhydrase B isoenzyme carboxymethylated at its histidine(200), and of the human C isoenzyme carboxyketoethylated at its histidine(63). The Michaelis-Menten parameters determined between pH 5.6 and 8.7 showed striking differences between the native and the alkylated enzymes, as well as between the modified enzymes themselves. The alkylations caused: (i) a decrease in the k(cat) values, particularly marked for the carboxymethylated B isoenzyme, (ii) a change in the apparent pK of the k(cat) curves, and (iii) a dependence of K(m) on pH, for the alkylated enzymes, in contrast to the pH-independent K(m) values of the native enzymes. The CO(2) hydration and esterase activities of the carboxymethyl B isoenzyme differ markedly in their pH dependence. A kinetic mechanism, which is found to be compatible with all the present observations, is proposed. The results indicate that the modifiable histidine residues do not play an essential role in the catalytic mechanism of the native carbonic anhydrases, but they may well influence the enzyme activity in a secondary role.


The role of X-chromosome inactivation during spermatogenesis (Drosophila-allocycly-chromosome evolution-male sterility-dosage compensation). Inactivation of the single X chromosome in the primary spermatocytes of species with heterogametic males is postulated as a basic control mechanism on the chromosomal level that is required for normal spermatogenesis. This view is supported by (a) cytological observations of X-chromosome allocycly in the primary spermatocytes of all male-heterogametic organisms that were adequately examined, (b) autoradiographic evidence of early cessation of transcription by the X chromosome in the mouse and three species of grasshopper, and (c) the male sterility of animals with certain X-chromosome rearrangements that cannot be attributed to misfunction of specific genes. X-chromosome inactivation during spermatogenesis is proposed as the ideal system for studies of genetic control at the chromosomal level.


Dose-response relationships for yields of major eye malformations following low doses of radiation to trout sperm.


Binding of thyrotropin-releasing hormone to plasma membranes of bovine anterior pituitary gland (hormone receptor-adenylate cyclase-equilibrium constant-( 3 H)thyrotropin). An assay for the binding of [(3)H]thyrotropin-releasing hormone ([(3)H]TRH) is described. Plasma membranes isolated from bovine anterior pituitary gland bind about 600 femtomoles of this hormone per mg of protein, as compared to 15 femtomoles per mg of protein in the total adenohypophyseal homogenate (40-fold purification). The equilibrium constant of membrane receptor-[(3)H]TRH binding at 0 degrees C is 4.3 x 10(7) L.M(-1), or a half-maximal binding of this hormone at 23 nM. The binding is time-dependent; addition of unlabeled hormone induces dissociation of the receptor-[(3)H]TRH complex with a half-life of 14 min. The binding of TRH is not altered by 10 muM melanocyte-stimulating hormone-release inhibiting hormone, lysine-vasopressin, adrenocorticotropin, growth hormone, prolactin, luteinizing hormone, insulin, glucagon, L-thyroxine, or L-triiodothyronine. K(+) and Mg(++) increase formation of the receptor-TRH complex at optimal concentrations of 5-25 mM and 0.5-2.5 mM, respectively, with inhibition at higher concentrations. Ca(++) inhibits binding of TRH at all concentrations tested.


Light chain sequences of human IgM cold agglutinins (variable-region subgroups amino-acid sequence-kappa light chain-N-terminal). The amino-terminal amino-acid sequence has been determined for the kappa light chains of nine IgM cold agglutinins with specificity for blood group-related carbohydrate antigens. Six of the nine sequences corresponded to the prototype VK(III) subgroup pattern, two to that of subgroup VK(II), and only one to the VK(I) subgroup. This distribution of kappa subgroups differs markedly from that of normal and myeloma proteins sequenced to date, where the VK(I) subgroup is more prevalent than either VK(II) or VK(III). Evidence is presented that supports the conclusion that the unusual subgroup distribution relates to the antibody property itself and not to some other attribute of these molecules.


Behavior and physiology of the monkey (Macaca mulatta) following 2500 rads of pulsed mixed gamma-neutron radiation.


Recurrent pulmonary embolism from upper extremity thrombophlebitis.


Neurofibromatosis and hypertension due to pheochromocytoma or renal-artery stenosis.


Human development and public health. Report of a WHO scientific group.


Demonstration of actomyosin in mesangial cells of the renal glomerulus. Antisera to human uterine actomyosin were prepared in rabbits and conjugated with fluorescein (F-AUAM). When F-AUAM was applied to frozen sections of normal human kidney which were then examined by ultraviolet light microscopy, it was observed that vascular smooth muscle, endothelium of arteries, veins, and peritubular capillaries and glomerular mesangial cells were immunofluorescent. Neither glomerular endothelium nor epithelial cells of Bowman's capsule or renal tubules were stained by F-AUAM. The specificity of antisera for actomyosin was confirmed by absorption and blocking studies, examination of a wide variety of tissues and immunodiffusion in agarose gel. It may be inferred from these data that mesangial cells are contractile. Contraction of the mesangium may play a significant role in regulating glomerular blood flow and in the reaction of the glomerulus to injury.


Simple method for the characterization of 5S RNA.


Liquid cation exchange--a basis for sensitive radiometric assays for aromatic amino acid decarboxylases.


Quide vs. Mellaril in chronic schizophrenic patients.


A controlled clinical trial of trifluperidol on a group of chronic schizophrenic patients.


Molindone and chlordiazepoxide in anxious neurotic outpatients.


A therapeutic trial with a combination of trimethoprim-sulphamethoxazole in rheumatoid arthritis.


A comparison of oral therapy with clindamycin and penicillin G in common gram-positive infections.


Double-blind study: Cleocin Palmitate and Erythrocin Pediatric in otitis media in children.


Therapy of the menopause with esterified estrogens standardized with sodium estrone sulphate.


Blood-level studies of ampicillin and dicloxacillin alone and in combination.


Placental transport of thyrotropin releasing factor in the rat.


Purification and properties of chorionic gonadotropin from the trophoblastic tissue of hydatidiform mole.


The negative feedback control by estradiol and progesterone of LH secretion in the ovariectomized rhesus monkey.


The preparation and specificity of antibody to thyrotropin releasing hormone.


Motoric engramming for sensory deprivation or disability.


In vitro proliferation and differentiation of hemic precursor cells from marrow and blood of naturally chimeric marmosets.


Histopathologic evaluation of the effects of new root canal sealers on monkey pulps.


Reaction of dog pulp and periapical tissue to two glucocorticosteroid preparations.


Tumor localization, dosimetry, simulation and treatment procedures in radiotherapy: the isocentric technique.


Treatment of retinoblastoma.

Treatment of retinoblastoma.


The treatment of orbital rhabdomyosarcoma of children with primary radiation therapy.


Radiation therapy in the management of lymph node metastases from head and neck cancers.


Inactivation of papain by S-methylation of its cysteinyl residue with O-methylisourea.


Molecular properties of rat pancreatic and parotid  -amylase.


Catalytic versatility of erythrocyte carbonic anhydrase. Kinetic studies of the enzyme-catalyzed hydrolysis of methyl pyridyl carbonates.


Extrinsic Cotton effects in a metal chelator-bovine carbonic anhydrase complex.


Studies on the mechanism of O-alkyl lipid synthesis.


Bacteriological evaluation of minocycline, a new tetracycline.


Thermal thresholds in man and monkey.

Thermal thresholds in man and monkey.


The orientation of DNA within 80-Angstrom chromatin fibers. Squashing salivary glands of Chironomus thummi larvae, Amblystoma tigrinum erythrocytes, or Spirostromum frequently results in stretched chromatin having highly oriented DNA as determined by polarized fluorescence microscopy of acridine orange-stained preparations. The examination of such material from C. thummi in the electron microscope indicates that the individual chromatin fibers have an average thickness of 80 A as is usually found in embedded and sectioned material. It is thus concluded that the DNA lies nearly parallel to the axis of these chromatin fibers. Detailed calculations of the polarization expected from various models of DNA packing are contained in an appendix.


Diastrophic dwarfism.

Diastrophic dwarfism.


Concerning the universality of a microtubule antigen in animal cells.


Sixteenth Bowditch lecture. The physiology of strong emotions: Cannon's scientific Legacy re-examined.


Regional cerebral blood flow in physiologic and pathophysiologic states.


Transit time as an index of the cerebral circulation.


Impedance methods for investigation of cerebral circulation.


A method for conservation of veins in the surgical cutdown.


Juvenile xanthogranuloma. An atypical case with study of ultrastructure.


Representation of slowly and rapidly adapting cutaneous mechanoreceptors of the hand in Brodmann's areas 3 and 1 of Macaca mulatta.


Thalamocortical relations in gustation.

Thalamocortical relations in gustation.


A progesterone-like factor detected by bioassay in the blood of the toad (Bufo bufo) shortly before induced ovulation.


Role of pars distalis and pars nervosa of the hypophysis in the water economy of the toad Bufo bufo bufo (L.).


Purification and properties of bacterial luciferases.


A lactate dehydeogenase specific to the liver of gadoid fish.


Microquantitation of thrombosthenin in human platelets by single radial immunodiffusion.


Glycolytic intermediates and adenine nucleotides of human platelets. II. Effect of short-term storage at 4 C.


Potassium intake and balance after open intracardiac operations.


Effect of intravenously administered fat on serum insulin levels.


Is histidine an essential amino acid in man?


Nutrition and development: the view of the planner.


A simplified hemagglutination test for farmer's lung.


Problems in the use of the in vitro toxigenicity test for Corynebacterium diphtheriae.


The John Barnwell lecture: Improving existing methods of control of tuberculosis: A prime challenge to the experimentalist.


Immunologic characterization of a lung surfactant preparation.


Observations on the action of rifampin and ethambutol alone and in combination with other antituberculous drugs.


Protein composition of intact and fractionated membranes isolated from dark and light grown cells of a blue green mutant of Rhodospirillum rubrum (BG 1 ).


Absence of photosystem 2 in heterocysts of the blue-green alga Anabaena.


Relationships between covalent binding of 3'-methyl-4-dimethylaminoazobenzene to liver protein and increases in the level of hepatic AMP deaminase.


A rapid screening procedure for some "street drugs" by thin-layer chromatography.


The use of tetrazolium salts in bioautographic procedures.


Comparative observations on the morphology of the mammalian periovarial sac.


Radiological research and social responsibility.


Measurement of OER and RBE of a 910 MeV helium ion beam, using cultured cells (T-1).


Osteological features characterizing the wrists of monkeys and apes, with a reconsideration of this region in Dryopithecus (Proconsul) africanus.


Systematic reconsideration and a revision of the nomenclature of Kenya baboons.


Purification and characterization of colicin D. Colicin D-CA23, obtained by sonic treatment of mitomycin C-induced cells of Escherichia coli K-12 W1485 (colD), was purified by ammonium sulfate precipitation, gel filtration on Sephadex G200, ion-exchange chromatography on diethylaminoethyl cellulose, and isoelectrofocusing. Polyacrylamide-gel electrophoresis, sedimentation velocity analysis, and antigenic analysis indicated that the preparation was homogeneous. Colicin D is composed entirely of amino acids and hence is a simple protein uncomplexed with lipid or lipopolysaccharide. It contains six residues of cysteine per molecule. The molecular weight of colicin D is approximately 92,000, as determined by sodium dodecyl sulfate-polyacrylamide-gel electrophoresis and gel filtration on Sephadex G200. Its sedimentation coefficient is 4.41S. The behavior of colicin D in solutions of sodium dodecyl sulfate and 2-mercaptoethanol indicates that it does not consist of subunits and exists as a single polypeptide chain. Its high molecular weight and presence of six cysteine residues per molecule distinguish colicin D from all colicins previously described. Although colicins D and E3 have similar modes of action, their gross molecular properties are entirely different.