Fractures in children with myelomeningocele.


A double blind comparison between doxepin and diazepam in the treatment of states of anxiety.


Objective assessment of anticholinergic side effects of tricyclic antidepressants.


Flupenthixol decanoate - controlled investigation concerning dosage -.


A comparison between lithium, placebo and a diuretic in premenstrual tension.


Immunosuppressive effects of ovalicin-semicarbazone.


Herbert Woodrow: 1883-1974.

Herbert Woodrow: 1883-1974.


The permeability of blood vessels in the guinea pig cochlea. II. Vessels in the spiral ligament and the stria vascularis.


Cerebellar projections to the nuclei ventralis lateralis and ventralis anterior thalami. Experimental electron microscopical and light microscopical studies in the cat.


Cortical and pallidal projections to the nucleus ventralis lateralis thalami. Electron microscopical studies in the cat.


Embryonic brain-growth in a fruit bat.

Embryonic brain-growth in a fruit bat.


Diabetes.

Diabetes.


Antibacterial therapy under special conditions: paediatrics.


The in vitro assessment of leucocyte chemotaxis.


Chemoreception in bacteria.

Chemoreception in bacteria.


The properties of the galactose-binding protein, the possible chemoreceptor for galactose chemotaxis in Escherichia coli.


Active site chemotactic factors and the regulation of the human neutrophil chemotactic response.


Chemotaxis of mononuclear leukocytes.

Chemotaxis of mononuclear leukocytes.


The regulation of leukotactic mediators.


Chemotaxis and random mobility. Clinical and biologic differentiation.


Chemotaxis in Escherichia coli analyzed by three-dimensional tracking.


Mathematical aspects of bacterial chemotaxis.


The tryptic peptides of rabbit muscle triose phosphate isomerase. 1. The peptides obtained by tryptic digestion of S-[(14)C]carboxymethylated rabbit muscle triose phosphate isomerase have been studied. 2. The first step in the fractionation of the tryptic digest was gel filtration on coupled columns of Sephadex G-25 and G-50. Further fractionation was carried out by paper electrophoresis and paper chromatography. 3. The digest contained 26 peptides and three free amino acids. The sizes of the peptides ranged from two to 29 residues. 4. The sequences of the peptides have been determined. 5. The length of the polypeptide chains is about 250 amino acid residues. 6. The variant sequences encountered were due to partial deamidation; this may be one of the reasons for multiple forms of the enzyme. 7. The chicken and rabbit enzymes are compared. 8. Detailed evidence for the sequences of the tryptic peptides has been deposited as Supplementary Publication SUP 50024 at the British Library, Lending Division (formerly the National Lending Library for Science and Technology), Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies can be obtained on the terms given in Biochem. J. (1973) 131, 5.


Nitrogenase of Klebsiella pneumoniae. Inhibition of acetylene reduction by magnesium ion explained by the formation of an inactive dimagnesium-adenosine triphophate complex. Acetylene-reducing activity of purified nitrogenase from Klebsiella pneumoniae was studied over a range of ATP and Mg(2+) concentrations at 15 degrees C, pH7.8. Inhibition at Mg(2+) concentrations of 2.5-30mm was due to the formation of the inactive complex, Mg(2)ATP. At higher Mg(2+) concentrations an additional inhibitory effect was observed. The results were consistent with a MgATP complex being the active substrate with an apparent K(m)(MgATP)=0.4mm.


Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. Ribitol dehydrogenase has been purified to homogeneity from several strains of Klebsiella aerogenes. One strain yields 3-6g of pure enzyme from 1kg of cells. The enzyme is a tetramer of four subunits, mol.wt. 27000. Preliminary studies of the activity of the enzyme are reported. Peptide ;maps' together with the amino acid composition indicate that the subunits are identical.


A mass-spectrometric sequence study of the enzyme ribitol dehydrogenase from Klebsiella aerogenes. The first detailed results of the application of a low-resolution mixture analysis approach to the sequence analysis of an enzyme, ribitol dehydrogenase, are given. Examples of the interpretation of the spectra of peptide mixtures derived from this protein are described. Evidence for new fragmentation patterns observed is reported, together with an explanation of the generation of ambiguous sequences by use of a low-specificity enzyme, thermolysin. The overall sequencing strategy evolved is assessed.


Mutationally altered rate constants in the mechanism of alkaline phosphatase. The hydrolysis of phosphate esters by a mutationally altered alkaline phosphatase from Escherichia coli was studied by both steady-state and transient-kinetic methods. The difference between the catalytic-centre activities of the mutationally altered and the wild-type alkaline phosphatases was found to vary with pH and at optimal pH values the modified enzyme had the higher activity. Stopped-flow experiments at acidic pH values showed that transient product formation by the mutationally altered enzyme was faster than that with the wild-type enzyme whereas the rate of the steady state was slower. In the alkaline pH region, the transient was observed in the reaction of only the modified enzyme and not the wild type. These observations permit a fuller characterization of the individual steps in the catalytic mechanism of alkaline phosphatase than is possible by study of only the wild-type enzyme.


Baker's yeast uridine nucleosidase. I. Purification to homogeneity.


Baker's yeast uridine nucleosidase. II. Enzymatic and kinetic properties.


Monitoring in anesthesia. Acid-base monitoring.


Monitoring in anesthesia. Outpatient procedures.


The apparent specificity of CO2 as a respiratory stimulus.


A new more potent analogue of LH-RH: [Des-Gly-NH2(10), pro-ethylamide9]-LH-RH.


The relationship between mother and embryo during the preimplantation period with particular reference to fertility and fitness of the offspring.


Human organ culture: applications in the screening of teratogenic drugs.


Ultrastructural and acetylcholinesterase investigations on the pancreas intrinsic innervation of two bird species (Columba livia domestica Gm. and Euodice cantans Gm.).


Prosthetic treatment for the edentulous cleft palate patient.


Frequency-modulated responses from urinary bladder on stimulation of telencephalic & diencephalic centres.


Euchromatic and heterochromatic behavior of the human X2 chromosome in cell cycle and cell development.


The current status of the concepts of physiological response specificity and activation.


Psychological stress and coping in adaptation and illness.


Associations between HL-A histocompatibility antigens and non-malignant diseases.


Operant conditioning: a new theoretical approach in psychosomatic medicine.


Family process and psychosomatic disease.


Quantification and psychological indicators of emotions: the content analysis of speech and other objective measures of psychological states.


Replication of the insect Chilo iridescent virus (CIV) in a poikilothermic vertebrate cell line.


Detection of cells producing antibody to hepatitis B surface antigen by an indirect hemolytic plaque assay.


Chronic trichloroethylene exposure.

Chronic trichloroethylene exposure.


A histochemical approach for diagnosis of lymphadenopathy.


Ultrastructural, morphometric and associated observations on experimental mastitis in cattle.


Serologic tests of rheumatic diseases in bilharzial hepatic fibrosis.


The site and characteristics of intestinal water and electrolyte loss in Escherichia coli-induced diarrhoea in calves.


Occupational stress and coronary heart disease: A review and theoretical integration.


Immunofluorescent study on pemphigus.

Immunofluorescent study on pemphigus.


Bacterial motility and chemotaxis: light-induced tumbling response and visualization of individual flagella.


Bacteriophage T4D-induced proteinase.

Bacteriophage T4D-induced proteinase.


Differential rate of ribosomal protein synthesis in Escherichia coli B/r.


Selective modification of cytidine, uridine, guanosine and pseudouridine residues in Escherichia coli leucine transfer ribonucleic acid.


Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis.


Orthotopic partial hepatic transplantation in dogs.


Survival of both donor and recipient in partial hepatic transplantation of dog.


Surgical treatment and operative results of vascular hypertension.


Inhibition of DNA synthesis and cell division in Salmonella typhimurium by azide. Evidence has been obtained that sodium azide is an inhibitor of cell division in wild-type and aziA strains of Salmonella typhimurium. The bacteria grown in media containing sodium azide and glucose formed long filaments. It has been found that sodium azide had a stronger inhibitory effect on DNA synthesis than on cell mass increase. When filaments produced by azide action were transferred to azide-free medium very rapid increase in DNA content was observed during the first 45 min. After this time, when relative DNA content was increased the rate of DNA synthesis was reduced and cell divisions reappeared. Inhibitory effect of azide on DNA biosynthesis in vitro was observed with toluenized cells of S typhimurium. Only ATP-dependent radioactive dTMP incorporation into DNA was affected by sodium azide. It had no effect on the incorporation in the absence of ATP. Mutant aziC was isolated in S. typhimurium by scoring for clones with normal cell division in the presence of sodium azide. Azide had much less effect on DNA biosynthesis in vivo and in vitro in aziC cells as compared with isogenic controls.


Nucleo-cytoplasmic interaction between oligomycin-resistant mutations in Saccharomyces cerevisiae. 1.A single-gene nuclear mutant of Saccharomyces cerevisiae, isolated as oligomycin-resistant, exhibits in vivo cross-resistance to venturicidin and collateral sensitivity to Synthalin. All three compounds are inhibitors of mitochondrial oxidative phosphorylation. Oligomycin resistance and Synthalin sensitivity are recessive, while venturicidin resistance is dominant. 2. Acytoplasmic mutant, also isolated as oligomycin-resistant, shows collateral sensitivity to both Synthalin and venturicidin. All three traits undergo mitotic segregation in diploids formed by crossing mutant and normal halpoids. 3. A novel nucleocytoplasmic interaction is observed in diploids formed by crossing haploid strains containing the nuclear and the cytoplasmic mutations, respectively. The dominant venturicidin resistance determined by the nuclear gene undergoes mitotic segregation, which results from a suppression of the nuclear phenotype by the cytoplasmic mutation. When a diploid mitotic segregant contains primarily mutant-type mitochondria, venturicidin resistance is completely suppressed. In haploids containing both the nuclear and cytoplasmic mutations, suppression is only partial. 4. Oxidative phosphorylation and ATPase in mitochondrial fractions isolated fromcytoplasmic mutant cells are less sensitive to inhibition by oligomycin than normal, but in vitro sensitivity to venturicidin is not significantly changed. In similar mitochondrial fractions isolated from normal and nuclear mutant cells, no significant differences in sensitivity to either inhibitor are detected. 5. The molecular basis for the nucleocytoplasmic suppression of venturicidin resistance may involve participation of mitochondrial membrane, plasma membrane or both. Either mitochondria can undergo changes in venturicidin sensitivity upon isolation, or the molecular entity which controls access of venturicidin to the mitochondria resides outside of the organelles. 6. Our data establish that aspects of the response in vivo of both venturicidin and Snythalin are controlled by the mitochondrial genome. 7. The nucleocytoplasmic interaction described here is the first example in which a specific restricted mitochondrial mutation modifies the phenotypic expression of a nuclear gene.


Genetics of resistance to macrolide antibiotics and lincomycin in natural isolates of Streptococcus pyogenes. Of 5 clinically isolated strains of Streptococcus pyogenes, 3 showed high-level resistance to erythromycin and lincomycin that was inducible by subinhibitory concentrations of these drugs (IR strains) while 2 strains exhibited constitutive erythromycin and lincomycin resistance (CR strains) which was expressed without prior exposure to low drug concentrations. The CR strain 15346 showed spontaneous loss of resistance whereas resistance in the other strains was quite stable even under curing conditions. The IR strain 13234 was found to be polylysogenic for at least 4 different phages designated P13234ma, mi, mu, and mo. Phage mo, antigenically distinct from the other three, was shown to mediate the transfer of the resistance determinant ERL1 of strain 13234. ERL1 if borne by appropriate strains was also transducible by the virulent phage A25. ERL1 behaved as a discrete genetic unit in transduction experiments, was not linked to either of two chromosomal regions governing resistance to antibiotics that affect the ribosome, could be transferred to recombination deficient hosts, represented a relatively large UV inactivation target, and showed no stimulation of transduction by low UV doses. These findings suggest that resistance to erythromycin and lincomycin in certain natural isolates of S. pyogenes is specified by, or under the control of, a plasmid.


Immunosuppressive therapy and reticulum cell sarcomas of the brain. A report of 2 cases.


Autoimmunity a cause of male sterility?

Autoimmunity a cause of male sterility?


Comparative investigations on the treatment of the varicose syndrome with 4-methyl-6,7-(bis-beta-diethyl-aminoethoxy)-coumarine hydrochloride (oxamarine), with the disodium salt of disulphuric ester of 4-methyl-aesculetol and with tri-hydroxy-ethylrutoside (troxerutin).


Masters education in nursing. Route to opportunities in contemporary nursing; 1974-1975.


Stereotactic limbic leucotomy: surgical technique.


The work of a psychosurgical unit.

The work of a psychosurgical unit.


Further observations from an experience of 660 cases of stereotactic tractotomy.


Stereotactic limbic leucotomy--a follow-up study of thirty patients.


Coeliac disease and autoimmunity.

Coeliac disease and autoimmunity.


Psychosurgery and the limbic system.

Psychosurgery and the limbic system.


Professor Dieska--an appreciation.

Professor Dieska--an appreciation.


Organization of controlled trials in paediatric liver disease.


Amoxycillin: pharmacokinetic studies in normal subjects, patients with pernicious anaemia and those with renal failure.


The role played by radiotherapy in the UKALL III series of trials for the treatment of acute lymphoblastic leukaemia in childhood.


Considerations on the surgical treatment of deep burns (4th degree).


Early skin coverage in extensive burns.

Early skin coverage in extensive burns.


On the problem of reconstruction after burns.


Early surgical treatment of the burned surface.


On the respiratory function of haemoglobin.


Surgical repair and reconstruction of the burned surface.


The interrelationship between sodium and calcium fluxes across cell membranes.


The natural history of amine oxidases.

The natural history of amine oxidases.


Regional flaps in head and neck surgery.


A metabolic and nutritional evaluation of burn neutrophil function.


Australia antigen, immunity and chronic liver disease. The hepatological and immunological profile of Australia antigen (HBAa) carriers in a large psychiatric institution.


A model on the induction by UV irradiation of Escherichia coli bacteria lysogenic with the bacteriophage lambda.


Method of repeated puncture of the heart and main vessels in chronic experiment.


Plasma insulin response to oral lactose and glucose-galactose in patients with lactose intolerance.


Letter: Public health hazard of antibiotic resistance in enterobacterial (E. coli and Salmonella) isolates from poultry in Ghana.


Activity and properties of the Penicillium citrinum milk-clotting enzyme.


The Paulesco affair in connection with the discovery of insulin.


Microcinematography: a useful tool for studying hypophyseal cells in monolayer culture.


Effect of insulin on the blood glucose level and histology of the principal islets of Channa punctatus (Bloch).


Stereology of axon terminals. A study based on reconstruction and goniometrical analysis of semi-thin electron-histochemical sections.


Proteolytic activity of human gastric juice.


Electrophysiological basis for a rational approach to antidysrhythmic drug therapy.


The influence current financing and reimbursement processes have on the practice of geriatric nursing. No. G-94.


Hypolipidaemic agents.

Hypolipidaemic agents.


Community health nursing practice. Introduction (dedication to Mrs. Maragaret Dolan). No. G-94.


The effect of metoclopramide on human gastric emptying and secretion.


The effects of left coronary artery ligation on rat heart muscle angiographic, morphologic and chemical studies:.


Prior irradiation can sensitize or protect bacterial cells from subsequent irradiation: a genetic and biochemical study.


Sensitization and repair in ultraviolet-irradiated bacteria.


New light on the photoreactivating enzyme.


Repair mechanisms involved in the recovery of phage lambda from ultraviolet damage.


Ultraviolet mutagenesis in bacteria: the inducible nature of error-prone repair.


Repair processes and dose-response curves in ultraviolet mutagenesis of bacteria.


The relevance of photobiological repair.


Photoproducts and their significance in radiation damage repair.


Mechanization and automation of qualitative and quantitative serological analyses by means of the Biodilutor and the Bioreactor.


An automatic device for the serotyping of Salmonella.


A study in test reproducibility between laboratories:  report of a Pseudomonas Working Party.


Problems in the shipment of fecal samples. Comparative studies on the efficacy of Stuart's transport medium and liquid nitrogen as the means of preserving enteropathogens.


The George Adlington Syme Oration: what puts the surge in surgery.


Atherosclerotic ulceration of the brachiocephalic artery.


Tumour immunology: a review of the present situation with particular reference to solid tumours and surgical implications.


Hemifacial atrophy: repair with a buried flap.


A comparison of cryoprecipitated plasma and albumin solutions for machine preservation of ischaemically damaged canine kidneys.


The prevention of acute tubular necrosis in renal transplantation by chronic salt loading of the recipient.


Compensatory and obligatory renal growth in babies and adults.


Chemical studies on damages of Escherichia coli by the immune bactericidal reaction. I. Release and degradation of phospholipids from damaged bacteria. When antibody-sensitized Escherichia coli B is treated with complement in the absence of lysozyme, bacterial phospholipids or fragments containing phospholipid appear in the surrounding medium. Almost at the start of the reaction, a little phosphatidylethanolamine (PE) appears in the lipid fraction extracted from the supernatant of the reaction mixture. Later it does not increase greatly in amount but free fatty acids (FFA) and lysophosphatidylethanolamine (LPE) appear and increase gradually. Addition of lysozyme to the reaction mixture changes the amounts of FFA and LPE released, but does not increase the numbers of the spots on a thin layer chromatogram of the lipid fraction of the supernatant. The FFA fraction contains no beta-hydroxymyristic acid from lipid A of the lipopolysaccharide complex.


Chemical studies on damages of Escherichea coli by the immune bactericidal reaction. II. Release of phosphatidylethanolamine from a phospholipase A-deficient mutant of E. coli during the immune bactericidal reaction. When an antibody-sensitized, phospholipase A-deficient mutant of Escherichia coli B/SM was treated with complement in the absence of lysozyme, bacterial phosphatidylethanolamine (PE) was liberated into the lipid fraction of the surrounding medium, but only traces of its degradation products were found in this fraction. Therefore, most of the degradation of bacterial PE to FFA and LPE observed in the usual immune bactericidal reaction (Inoue et al., 1974) must be the result of the action of bacterial phospholipase A which is activated or becomes accessible to its substrate on formation of lesions by complement. The mechanism of complement-mediated formation of membrane lesions is discussed on the basis of these results.


Phospholipase A-deficient mutants of Escherichia coli B. Phospholipase A-deficient mutants were isolated from Escherichia coli  B/SM as follows. Replica plates were incubated to allow formation of colonies and then overlayed with soft agar containing washed sheep erythrocytes, lecithin Ca++, colistin, lysozyme and streptomycin. The mutant colonies were detected as colonies without hemolytic zones. Two or three cycles of treatment with mutagen and selection were necessary for their isolation. The mutants obtained could grow in a synthetic medium with glucose as the sole carbon source, and their phospholipid compositions were similar to that of the parent. They also gave the same agglutination titer as the parent with rabbit antiserum against the parent strain. They supported the growth of all members of the T-series of bacteriophages as effectively as the parent. Some hemolytic substance was produced from either lecithin or bacterial constituents when the mutants were infected with T even phages, but not with T odd phages. When the parent strain was infected with either T1 or T4, free fatty acids (FFA) were produced in the cell debris. Only a trace of FFA was formed in the debris of one of these mutants on infection with T4 and no FFA was formed on infection with T1.


Temperature-sensitive mutants of Escherichia coli B which can grow in high-osmotic medium at the nonpermissive temperature. Two temperature sensitive (TS) mutants (C4 tos and D2 tos) were isolated after mutagenesis of E. coli B/SM by N-methyl-N'-nitro-N-nitrosoguanidine (NMNG), which can grow even at 42 C in high-osmotic medium supplemented by addition of sucrose, NaCl or other compounds. Neither of the mutants lyzed when transferred to low-osmotic medium after growning at the nonpermissive temperature in high osmotic medium. One of these mutants, C4 tos, grew at 42 C in a long filamentous form. When bacteria growing exponentially at 30 C were shifted to 42 C, they continued to grow at a reduced rate even in low-osmotic medium. This strain could also grow or start to grow in low-osmotic medium when supplied with a factor or factors secreted from growing bacteria of another strain. This mutant strain could grow in low-osmotic medium at 42 C when it was cultured anaerobically. The other mutant strain obtained (D2 tos) displayed normal morphology even when grown at 42 C. When it was shifted from 30 to 42 C in low-osmotic medium, increase of mass, measured as optical density, continued for a while, but viability, measured as the number of colony-formers, stopped increasing and then decreased rapidly.


Inhibition of protein synthesis by ricin: experiments with rat liver mitochondria and nuclei and with ribosomes from Escherichia coli. 1. Ricin, a toxic protein from the seeds of Ricinus communis which inhibits poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes (Montanaro et al., 1973), does not affect protein synthesis by isolated rat liver mitochondria. 2. The toxin is ineffective also on poly(U)-directed polyphenylalanine synthesis in reconstituted systems with ribosomes isolated from rat liver mitochondria or from Escherichia coli. 3. Ricin inhibits protein synthesis by isolated rat liver nuclei, but at concentrations much higher than those affecting rat liver ribosomes.


Lomofungine as an inhibitor of nucleic acid synthesis in Saccharomyces cerevisiae. 1. The antibiotic lomofungin was found to be a potent inhibitor of both DNA and RNA synthesis in Saccharomyces cerevisiae. Under selected growth conditions inhibition of DNA synthesis by the drug preceded inhibition of RNA synthesis. 2. Although in general lomofungin inhibited synthesis of ribosomal RNA and polydisperse RNA more effectively than that of low-molecular-weight RNA, under certain conditions the drug inhibited almost completely synthesis of both 4S and 5S RNA. 3. Inhibition of both RNA and DNA synthesis may be explained if RNA synthesis is required for DNA synthesis in yeast. Alternatively, lomofungin, in addition to interacting with DNA-dependent RNA polymerase, might interfere with a component(s) of the DNA-synthetic apparatus. The drug may thus prove to be of considerable value in studies of DNA synthesis in eukaryotes.


Oral salbutamol in asthma-a preliminary report.


Bibliography of medical entomology in Iraq.


Tropical pathology.

Tropical pathology.


Entomological aspects of filariasis control in Sri Lanka. Historical events and suitable environmental conditions in the southwestern coastal areas of Sri Lanka have led to the establishment of a zone of endemic filariasis caused by Wuchereria bancrofti and transmitted by Culex pipiens fatigans. The previous Brugia malayi foci, scattered over widely dispersed areas of the island, were apparently completely eliminated as a result of control of the Mansonia vectors by the destruction of the larval host plants in their swamp habitats. Control measures by the Anti-Filariasis Campaign against W. bancrofti and C. p. fatigans have greatly reduced the human infection rates in the endemic coastal belt and have kept the rate in the dense population to less than 1% over the last several years. This paper assesses the entomological aspects of the control programme during the years 1970-72.


Modification by a latent contaminant of glomerular pathology in mice infected with Plasmodium berghei. This study was designed to determine, by means of electron microscopy, the effect of latent contaminants-which are associated with the syringe passage of the parasite-on the findings in the glomeruli of P. berghei-infected mice. A rapid alteration of the glomerular basement membrane was observed in mice infected with the syringe-transmitted N strain, but not in those infected with the cyclically passaged Nig strain. Glomerular changes were also seen in mice inoculated with nonparasitized blood from normal mice, obtained after 16 passages by syringe. It appears that these changes were provoked by a latent contaminant that had proliferated after passages of the parasite through mice, and that they constitute a secondary immune reaction.


Prevention of drug resistance in rodent malaria by the use of drug mixtures. Development of resistance to chloroquine in rodent malaria is inhibited by giving this compound together with a potentiating mixture of pyrimethamine and sulfadoxine but this does not prevent the development of resistance to the last two compounds. The use of drug mixtures should be explored as a means of "protecting" chloroquine or new blood schizontocides intended for mass chemotherapy against human malaria. However, no general rule can be laid down without testing specific drug mixtures in long-term experiments in a suitable model such as rodent malaria.


Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria. In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration.


Production of rabies fluorescent conjugate by immunization of rabbits with purified rabies antigen. Fluorescein-labelled antirabies virus conjugate was produced by hyperimmunizing rabbits with a purified rabies virus (CVS-27). The conjugate had a working dilution of >/=1: 500 in the rabies fluorescent antibody test. Stability under lyophilization was satisfactory.


Artistic expression of psychopathology through the media of art therapy.


The psychology of monster figures.

The psychology of monster figures.


Clinical and experimental liver grafting.


'Basement membrane diseases': a review.

'Basement membrane diseases': a review.


Annotations on Guy's Hospital in London by Dr Jacques-Pierre Pointe.


Accidental intravenous halothane.

Accidental intravenous halothane.


Charlotte Bühler December 20, 1893 - February 3, 1974.


William R. Looft February 9, 1944 - November 17, 1974.


A phenomenological approach to development: the contributions of Maurice Merleau-Ponty.


Reticulum cell sarcoma producing bilateral proptosis.


Cognitive functioning in middle and old age adults: a review of research based on Piaget's theory.


Lid trauma.

Lid trauma.


Practical management of ocular injuries. Penetrating wounds of the anterior segment.


Electrophoresis of the proteins of the nuclear polyhedrosis virus of Porthetria dispar.


Biochemical properties of polyhedra and virus particles of the cytoplasmic polyhedrosis virus of Bombyx mori.


A radioimmunoassay for the cytoplasmic polyhedrosis virus from Bombyx mori.


Sociometric and disruptive behavior as a function of four types of token reinforcement programs. Children in a first-grade classroom were divided into four groups. Baseline measures of disruptive classroom behavior were taken on a well-behaved and disruptive child in each group. Following baseline, four types of token economies were simultaneously introduced and rotated every 10 days within a Latin Square design. The token economies were: (1) individual reinforcement determined by individual performance; (2) group reinforcement determined by the behavior of the most disruptive child; (3) group reinforcement determined by the behavior of the least disruptive child; (4) group reinforcement determined by the behavior of a randomly chosen child. The token economies were compared on their effectiveness in changing target behavior, preference by the targets, ease of use, and cost. Additionally, sociometric responses were taken on questions of responsibility, friendship, and funniness. Results showed a significant decrease of inappropriate behavior for the disruptive children and no difference between the effectiveness of the four types of token economies in producing behavior change. However, there were other differences that indicated that the system in which group reinforcement was determined by a randomly selected child would be desirable for most teachers. Results also showed changes in the sociometric status of the disruptive children. As predicted, disruptive children were rated as more responsible when they were in the group reinforcement determined by the most disruptive child in the group token economy. Using behavior modification techniques indirectly to change sociometric status is suggested as offering a new potential technique for behavior change agents.


Ernest Ward and collective investigations.


Total ear loss due to trauma. Case report.


Surgical aspects of transplantation in diabetic patients.


End-stage diabetic nephropathy. Discussion: problems in transplantation.


Renal transplantation in insulin-dependent diabetic patients.


End-stage diabetic nephropathy. Discussion: psychosocial problems.


Critical remarks on the stereotaxic treatment of epilepsy. The analysis of experiences with 43 patients treated stereotaxically for epilepsy, shows that the stereotaxic method can play an important role 1) in the investigation of the structures in epileptic activity; 2) in proper management of these cases. According to deep electrode records, the epileptic focus seems to be like a system of anatomical structures, which are functionally interdependent, and its relationship can be plotted on a schematic graph, which must be calculated in the strategy of treatment with the combined performances. In spite of this results are not satisfactory. New methodological approaches should be devised, such as longitudinal stereotaxic hippocampectomia, which is suggested as promising.


Social and psychological rehabilitation of the diabetic transplant patient.


Magnitude of the renal failure problem in diabetic patients.


Pancreatic transplantation in New York.

Pancreatic transplantation in New York.


End-stage diabetic nephropathy. Discussion: The problem of end-stage diabetic nephropathy.


End-stage diabetic Nephropathy. Discussion: vascular and visual complications.


Neuropathy, retinopathy and biopsy findings in transplanted kidney in diabetic patients.


Microsurgical repair of small nerves. Experimental study of regenerative processes. The Authors describe an experimental study of regenerative processes of small nerves after microsurgical repair. The results obtained indicate that: the carefully cleaning up the operative fields is necessary; putting strain on the two stumps as well as over-tight stitches must be avoided; the perfectly positioning stumps, without their misalignment, is mandatory.


Metabolic problems in long-standing insulin-dependent diabetic patients.


Metabolic problems in diabetic patients undergoing renal transplantation.


Insulin and glucose metabolism in renal insufficiency.


Glucose intolerance in the hemodialyzed patient: a brief overview.


End-stage diabetic nephropathy. Discussion: metabolic complications.


Neuropathy in transplanted diabetic patients.


Studies on murine leprosy bacillus. XII. Reproduction test of the diseases in mice using small doses of the thirteenth subculture of the supposed Hawaiian strain of Mycobacterium lepraemurium.


A discussion of some single-compartment systems using intravascular tracers for the estimation of respiratory parameters.


Darkfield histophotography.

Darkfield histophotography.


The results of 'bone setting' in Anglo-Saxon times.


Observations on the distribution of data-processing articles in the biomedical periodical literature.


The role of the physician-computer interaction in the acquisition and interpretation of scintigraphic data.


Clinician versus computer in the choice of 11 differential diagnoses of jaundice based on formalised data.


Immunofluorescent detection and quantitation of autoantibodies--development of a routine service.


The effect of injection and infusion of LH-RH on serum LH and FSH in normal males and in boys with delayed puberty.


Pre-surgical treatment of the burned surface: open-air method.


The early surgical treatment of burns.

The early surgical treatment of burns.


The late surgical treatment of the unhealed burn.


Thermoregulation in man in relation to personality pattern and to disease.


Modern theories on the location and function of the thermoregulatory centres in mammals including man.


Habituation.

Habituation.


Response to weightlessness.

Response to weightlessness.


Acclimatization and adaptation to high altitude.


Meteorological effects on short term rhythmic biological phenomena in animals.


Meteorological effects on short term rhythmic biological phenomena in man.


Meteorological effects on long term rhythmic (seasonal, pseudo-seasonal or yearly) physiological phenomena in man. Miscellaneous phenomena.


Seasonal variations of basal metabolism and body fluid.


A case of de Toni-Caffey's syndrome with isolated involvement of the mandible.


Seasonal cycles of human conception.

Seasonal cycles of human conception.


Recent advances in problems of mammalian hibernation.


Letters to the editor: Spina bifida and education.


In memoriam Lészló Münster.

In memoriam Lészló Münster.


Bertalan Stiller and the constitution theory.


Dr. B. Dumbovich. 1907-1973.

Dr. B. Dumbovich. 1907-1973.


Orthopaedic surgery-yesterday and tomorrow.


Pathogenesis of diabetic retinopathy.

Pathogenesis of diabetic retinopathy.


"Clinical research - the tale of a trial.".


Pacific Caost Oto-Ophthalmological Society. List of officers.


Immune reactions and corneal graft rejection.


"Some welsh politicians and their illnesses.".


Investigations on the subcellular localization of O-antigens in Salmonella enteritidis by Means of Ferritin-conjugated antibody technique.


Studies on the development of endocrine glands in fishes. III. Morphogenesis of the endocrine pancreas in Clarias batrachus L.


New possibilities in the exploration of male hypogonadism.


Ultrastructure of the mouse pancreas after aurothioglucose administration.


Seasonal changes in pituitary prolactin and growth hormone content of field voles in different reproductive states (Microtus arvalis Pall., Rodentia).


Hundred years ago, the first intra-venous anesthesia in Ghent.


The first intravenous general anesthesia in the world.


The integrative action of the gigantopyramidal cortical area.


Serological examination of E. Coli strains isolated from calves.


New aspects of the role of serotonin in the insulin release mechanism.


Electron microscope study of temperature-sensitive mutants of Escherichia coli K12: Notes on the method and preliminary characterization.


The Uppsala school in separation science and the development of bioaffinity chromatography.


High number of antigen-binding cells in unimmunized mice and possible occurrence of multispecific lymphocytes.


Ultrasonic scaling.

Ultrasonic scaling.


[Amoxicillin: microbiological activity in vitro and in vivo (author's transl)].


An aid for the manipulation of partial dentures by handicapped patients.


Transfer RNA and protein synthesis.

Transfer RNA and protein synthesis.


Phylogenic studies on ribosomal proteins.


Some unsolved general problems of phage lambda development.


Host interference with expression of the lambda N gene product.


Lysogenization by bacteriophage lambda. II. Identification of genes involved in the multiplicity dependent processes.


Lysogenization by bacteriophage lambda. III. Multiplicity dependent phenomena occuring upon infection by lambda.


Perspectives in myogenesis.

Perspectives in myogenesis.


Marcia Crocker Noyes, medical librarian: the shaping of a career. This study explores the accomplishments of Marcia Crocker Noyes (1869-1946) in depth and examines how her unobtrusive, yet extremely influential, personality contributed to success in medical librarianship. In the library of the state medical society of Maryland and in the Medical Library Association, this pioneer medical librarian acted as a revitalizing force, and thus was in part responsible for the survival and subsequent growth of both institutions. Perhaps as important as her concrete contributions to medical libraries was the legacy which Miss Noyes bequeathed to her colleagues. She not only shaped the vocation of medical librarianship, but also by her example, stressed the dedication to the future necessary for one to be termed a professional.


Past-president Hetzner retires.

Past-president Hetzner retires.


The Gethin  Shilling.

The Gethin  Shilling.


Sam W. Hitt. President, Medical Library Association 1974/75.


Officers and council of the Ophthalmological Society of Egypt at the annual meeting March 1973.


The history of Medicine in Bristol and of the Bristol Medico-Chirurgical Society.


Medical Journalism in the West of England 1889-1970.


The history of Psychiatry in Bristol.

The history of Psychiatry in Bristol.


Cell-mediated immunity in Cryptococcosis.


Host cell proliferation in response to skin allografts on alymphatic pedicles.


Cellular immunity in pyelonephritis: inhibition of the spleen cell response to the mitogen concanavalin A.


Lymphocyte transformation and macrophage migration inhibition by electrofocused and gel-filtered fractions of group A streptococcal filtrate.


Antibodies against testicular germinal cells in lepromatous leprosy. Testicular germinal cell antibodies were found in 44 of 59 patients with lepromatous leprosy and in 4 of 10 patients with tuberculoid disease.  A similar pattern was found in 12 of 262 controls and normal subjects.  The antibody was found to be of the IgG class and 40 of 49 of these antibodies were shown to be complement fixing.  Spermatozoal antibodies were detected in 12 patients, but no ovarian antibodies were found in any specimen.  There was no close correlation between erythema nodosum leprosum and testicular antibodies.  It was found that the characteristic of the testicular antibody in leprosy was its ability to be absorbed by Mycobacterium BCG suspension suggesting that this is another antibody induced by infection.  A similar fluorescent pattern was seen in some patients who did not have leprosy, but in these cases, it could not be abolished with BCG.  It is concluded that autoimmunity may be 1 of the factors involved in the pathogenesis of orchitis in leprosy.


Elimination of Mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria.


The role of antibody in T-cell responses.


North American sport history: a review of North American sport historians and their works.


Philosophy of physical education and sport (a review of the literature).


Research methodology in the sociology of sport.


Psychological effects of physical activity.


Methodology in historical research.

Methodology in historical research.


Data analysis: decompositions, reformulations, and iterative processing.


Minority group involvement in sport: the black athlete.


The effect of synthetic FSH-LH/RH on plasma FSH, LH and 17beta-estradiol in women under oral steroid contraception.


Enteropathogenic Escherichia coli and neonatal diarrhoea.


Double blind trial of mefenamic acid, aspirin and placebo in patients with post-operative pain.


Protection by spironolactone and different antidotes against acute organic mercury poisoning of rats.


Cannabinoids in the urine of man after single and subchronic oral doses of marihuana.


Drug abuse: models of treatment and their consequences.


Proceedings: In vivo quantitative decalcification method and its application.


Isolation and characterization of an esterase-active enzyme from pronase with special reference to activation of Clostridium botulinum type E progenitor toxin. (1) By sequential chromatography on CM-Sephadex, SP-Sephadex and Sephadex G-100, an esterase-active enzyme was isolated from a commercial preparation of pronase, (2) The purity of the isolated enzyme was proven by disc electrophoresis and sedimentation analysis. (3) The molecular weight of the esterase-active enzyme was approximately 16,000. The sedimentation coefficient was 1.85 S. The N- and C-terminal amino acids were asparagine and valine, respectively. (4) The enzyme was similar to that of bovine trypsin in the substrate specificity. It appeared to be the same as the trypsin-like enzyme isolated from pronase by Wähyby (1968). However, the relative rates of hydrolyses of different substrates by the enzyme differed from those of bovine trypsin. (5) The enzyme activated Clostridium botulinum type E progenitor toxin. Even a higher toxicity was resulted by treating the progenitor toxin with this enzyme than with bovine trypsin. (6) The results support the hypothesis that activation of type E progenitor toxin involves hydrolysis of a lysine ester bond.


Comparison of direct and indicator-dilution measurements of flow rate and mean circulation time.


A simple method of surface replication of the cornea.


Assessment of a haemagglutination test for thyroid microsomal antibody.


Antibiotics literature index-a select bibliography.


Post-mortem histology of the islets of Langerhans in juvenile diabetes mellitus.


Clinical response in asthma to oral and inhaled betamethasone valerate.


Betamethasone valerate treatment of steroid dependent children.


Betamethasone valerate aerosol in children not on previous  steroid therapy.


Experience in the use of betamethasone valerate by aerosol in asthmatic children.


Betamethasone valerate and beclomethasone dipropionate aerosols in patients with asthma.


A comparison of betamethasone valerate, beclomethasone dipropionate and placebo by inhalation for the treatment of chronic asthma.


The effect of betamethasone valerate aerosol on exercise-induced asthma in children.


Betamethasone valerate in corticosteroid dependent chronic asthmatics. A preliminary report.


A double-blind assessment of betamethasone valerate in the control of asthma.


Laboratory and clinical studies with clotrimazole.


A double-blind comparison of clotrimazole and nystatin vaginal tablets in candida vaginitis.


Trials of the use of clotrimazole in the treatment of oral candidiasis in newborn babies.


The diagnosis of systemic fungal infection in renal transplant patients and treatment with clotrimazole.


Clotrimazole in the treatment of ocular infection by Aspergillus fumigatus.


Clinical studies with oral clotrimazole.


Clinical experience in the local treatment of dermatomycoses with clotrimazole.


The topical therapy of pityriasis versicolor with clotrimazole.


An open trial of topical clotrimazole in dermatomycoses.


Topical clotrimazole in dermatophytosis in a prison environment.


Clinical trial of clotrimazole in the treatment of superficial fungal infections.


Dermatomycoses: a brief history of therapy and initial results with clotrimazole.


Double-blind comparison of clotrimazole with Whitfield's and nystatin ointments.


A double-blind comparison of clotrimazole and tolnaftate therapy of superficial dermatophytoses.


Treatment of candidiasis and trichomoniasis of the female genital tract.


The incidence of vaginal candida and trichomonas infections and treatment of trichomonas vaginitis with clotrimazole.


The treatment of trichomonas and candida vaginitis with clotrimazole vaginal tablets.


An open trial of local therapy with clotrimazole for vaginal candidiasis.


Vaginal candidiasis in pregnancy--a trial of clotrimazole.


Clotrimazole in the treatment of acute and "resistant' vaginal candidiasis.


A preliminary report on a trial of clotrimazole against vaginal candidiasis in venereology.


A trial of clotrimazole and nystatin in vaginal candidiasis.


Treatment of vaginal candidiasis with clotrimazole.


Absence of toxic or therapeutic interaction between  penicillamine and previously administered gold in a trial of penicillamine in rheumatoid disease.


The silk spina buggy.

The silk spina buggy.


A severe case of fat embolism successfully treated with positive end-expiratory pressure respiration.


Family response to the mental illness of a relative: a review of the literature.


Public attitudes toward mental illness: a review of the literature.


Ethical and legal considerations in high risk studies of schizophrenia.


Introduction to Manfred Bleuler's "The offspring of schizophrenics".


Children at risk: the search for the antecedents of schizophrenia. Part I. Conceptual models and research methods.


Children at risk: the search for the antecedents of schizophrenia. Part II: ongoing research programs, issues, and intervention.


Action mechanism of 3',4'-dideoxykanamycin B (DKB) on Klebsiella pneumoniae.


Histological observations in one-stage bilateral lung allotransplantation in dogs.


An overview of lathyrism.

An overview of lathyrism.


[Studies on the skin grafts performed between adult specimen of Bufo viridis and Bufo vulgaris].


Modes of multiplication in an unstable spheroplast type F-form of Escherichia coli K12(lambda).


Temperature and hydrostatic pressure effects on gelatinase activity of a Vibrio sp. and partially purified gelatinase.


Effect of alloxan administration upon Channa punctatus (Bloch). Channa punctatus, a fresh water teleost, was administered intramuscularly with alloxan in doses varying between 200 and 600 mg/kg body weight. The course of cytological events occurring in the islets of alloxanized fish was followed over a period of 120 hours post injection. Alloxan caused mild degranulation of some of the beta cells in the beginning but later nuclear pycnosis, vacuolization and necrosis of the beta cells was observed. Like other vertebrates, Channa punctatus is alloxan-sensitive and its islet beta cells are susceptible to the cytotoxic effects of alloxan.


The story of hypertensin.

The story of hypertensin.


Ultrastructural features of the healing area after everting and inverting suture of the small intestine in rabbits.


"Secrets of a Soul": an early psychoanalytic film venture.


"Traduttori, traditori": a Freud-Fliess letter.


Some historical aspects of the drug-free therapeutic community.


A controlled study using cyclazocine in the treatment of narcotic addiction.


Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.


Storage carbohydrates during starvation of yeast.


[Tissue levels of "cefazolin" in man after parenteral administration (author's transl)].


Role of valyl-tRNA in the regulation of the biosynthesis of valyl-, isoleucyl-, and leucyl-tRNA synthetases in yeast.


Historical reflections on American legal psychiatry.


The residual virulence of the Rumanian strain of B.C.G.


The carriage of Rhizobium by leguminous seeds after floral spray.


Use of numerical taxonomy in the genus candida and certain related yeast genera.


Bacteriology of tuberculosis.

Bacteriology of tuberculosis.


Experiences with BCG vaccination in Indonesia.


Micromethod of niacin test for clinical laboratory.


Fully supervised intermittent chemotherapy in the Canberra Chest Clinic 1968--72.


Radioimmunoassay and saturation analysis. Pituitary and placental glycopeptide hormones.


Causation of neural tube defects: clues from epidemiology.


On the sequencing of action.

On the sequencing of action.


The afferent regulation of learnt movements.


Selective antimetastatic treatment--current status and future prospects.


Surgery for carcinoma of the urinary bladder.


Production of respiratory-deficient mutants of Saccharomyces cerevisiae by (-) luteoskyrin and (+) rugulosin.


Integration of chemotherapy into combined modality therapy of solid tumors. IV. Malignant melanoma.


On the antibiotical activity of gamma-irradiation products of chloramphenicol.


Analogues of luteinizing hormone-releasing hormone with modification in position 8.


Separation and some characterizations of NADPH-enoyl CoA reductase(s) from Candida albicans.


Immunofluorescent tracing of smooth muscle contractile protein antigens in tissues other than smooth muscle.


Auto-antigens of human spermatozoa. I. Solubilization of a new auto-antigen detected on swollen spermheads.


Standardization of lymphocyte transformation to Candida immunogen.


Migration inhibition factor and blast transformation in human lymphoid cultures stimulated by different agents.


Immunopathology of bullous pemphigoid. Basement membrane deposition of IgE, alternate pathway components and fibrin.


Complement activation in children with acute malaria.


'People with oral problems'--or: Why some patients act that way.


Inhibition by C3 fragments of C3-dependent rosette formation and antigen-induced lymphocyte transformation.


Case report/use of inserts to ease severe gagging.


Burning out wax sans smoke, odor.

Burning out wax sans smoke, odor.


One-appointment technic to form a crown base.


Vability assessment of the preserved heart: a brief review of current experimental techniques.


The Guy's Hospital Physical Society (1771-1852).


Immunofluorescent detection of factor VIII-related antigen in human platelets and megakaryoctes.


Metabolic regulatory functions of oxalacetate.


Molecular nature of isozymes.

Molecular nature of isozymes.


Covalently bound Flavin Coenzymes.

Covalently bound Flavin Coenzymes.


Obituary: Dr. Yusuke Sumiki.

Obituary: Dr. Yusuke Sumiki.


Studies on mikamycin B lactonase. I. Degradation of mikamycin B by Streptomyces mitakaensis.


Some chemical and biological characteristics of showdomycin.


Antimicrobial activities of indole.

Antimicrobial activities of indole.


The present situation of clinical monitoring of the fetus during labor.


The necessity for thermal prophylaxis in the neonate.


A rapid procedure for testing the integrity of the maternal-fetal barrier in spontaneously delivered placentas.


Recent investigations on neonatal fat metabolism.


Dr Hunter's "Gravid uterus" - a bicentenary note.


Artist versus engraver in William Hunter's "Anatomy of the human gravid uterus", 1774.


Society and rights of the mentally ill: a historical persepctive of the Chinese.


The development of the laryngoscope.

The development of the laryngoscope.


Editorial: Our medical heritage.

Editorial: Our medical heritage.


Changes in the hemodynamic, ventilatory and respiratory parameters following saline, isoproterenol and racemic epinephrine aerosol therapy in patients on IPPV.


Arab medicine and society.

Arab medicine and society.


Alaa El Deen Ibnul Nafiess: discoverer of pulmonary circulation.


Study of pituitary function in the presence of pituitary adenomas.


Discovery of the pulmonary circulation by an Arab in the thirteenth century.


A community approach to services for the retarded.


Intracranial ventricular system in children with spina bifida custica.


The measurement of early intellectual functioning: contributions from developmental psychology.


Factor content of the WAIS with separate digits-forward and digits-backward scores for a borderline and mentally retarded sample.


Aetiology of duodenal ulcer: an investigation into the buffering action and effect on pepsin of bran and unrefined carbohydrate foods.


Dialysis support required for renal transplantation.


Staphylococcal food poisoning and botulism.


Renal transplantation in juvenile diabetics.


Diagnosis of renal allograft rejection by 99mtc sulfur colloid visualization.


Differential effect of immunosuppressive agents on T and B lymphocytes.


The efficacy of prophylactic irradiation in altering renal allograft survival.


Risk factors in human renal transplantation.


Patient financing in the first year of the end-stage renal disease (esrd) program.


Cadaver allograft function: the effects of retrieval and preservation.


The significance of air embolism induced during pulsatile perfusion of the kidney.


Prevention of irreversible ischemic damage in renal preservation by pharmacological manipulation.


Self dialysis 1974.

Self dialysis 1974.


Effects of low temperature preservation on metabolite levels of dog renal cortex.


Lower urinary tract diversion and reconstruction in renal transplant patients.


Bilateral nephrectomy for renal failure and hypertension due to malignant nephrosclerosis.


Experience with hemodialysis and renal transplantation in patients with malignant hypertension.


Clinical evaluation of bilateral nephrectomy.


Bolus doses of steroids in transplantation.


Scintiphotos in the diagnosis of renal allograft malfunction.


The spleen in chronic renal failure and renal transplantation.


Isotopic evaluation of renal homografts.


Immunopathologic studies of repeated recurrent glomerulonephritis in an allograft recipient.


A randomized, controlled, prospective study of the effect of alternate-day prednisone on renal transplant function.


The Stewart-Peters organ bank: clinical application to cadaver renal transplantation.


Control of plasma aldosterone concentration during hemodialysis.


Water treatment for hemodialysis: a review.


Projecting future need for dialysis beds - a computer model.


Rehabilitation of patients treated by dialysis or transplantation.


Factors in infectious complications following cadaver renal transplantation.


"Transplant lung" secondary to renal allograft rejection.


Lymphoceles associated with renal transplantation: report of fifteen cases and review of the literature.


Second renal transplants: immunological and surgical considerations.


Functional difference in transplantation of fragmented renal medulla and monolayer culture of renomedullary interstitial cells.


Successful renal transplantation in patients with circulating antibodies to glomerular basement membrane.


Immunologic implications of lymphocyte depletion.


Quality control of thrombogenic properties of clinical ALG.


Differentiation of acute tubular necrosis and rejection by dual radionuclide transplant renography.


The importance of donor protection by furosemide and steroids in cadaveric kidney preservation.


Long-term kidney preservation with a new plasma perfusate.


Myocardial metabolism during acute shock induced by hemorrhage, endotoxin, or physostigmine infusion.


Heart triglycerides in health and disease.


From organisms to the cell: the history of metabolism.


Mitochondria in the contraction and relaxation of heart.


Dr. Douglas E. Smith - physiologist and photobiologist.


List of the photodynamic substances.

List of the photodynamic substances.


Molecular mechanisms of photodynamic compounds.


Photodynamic effects on molecules of biological importance: amino acids, peptides and proteins.


Photo-C4-cyclo-addition reactions to the nucleic acids.


The dye-sensitized degradation of nucleotides.


Photodynamic action: a valuable tool in molecular biology.


Genetic damage by photodynamic action: introductory remarks.


Some principles of dosimetry in photodynamic action experiments.


Genetic effects of photodynamic action.

Genetic effects of photodynamic action.


Genetic damage by photodynamic action and recombination of bacteriophage.


Light sources and detectors.

Light sources and detectors.


Photorepair of biological systems.

Photorepair of biological systems.


Dark repair of DNA damage.

Dark repair of DNA damage.


Growth delay and photoprotection induced by near-ultraviolet light.


Analysis of photoenzymatic repair of UV lesions in E. coli by light flashes.


Analysis of irradiated material.

Analysis of irradiated material.


Medical problems concerning the control group.


Non-radiation effects of thorotrast and other colloidal substances.


A short history of genetic counseling.

A short history of genetic counseling.


Management of retinal detachment.

Management of retinal detachment.


Treacher Collins prize essay, 1974. Value and potential of microscopy in ophthalmic surgery.


Endothelium of the corneal graft.

Endothelium of the corneal graft.


Wardrop Lecture, 1974. James Wardrop: a brief review of his life and contributions.


Bullous haemorrhagic ulceration, a variant of pyoderma gangrenosum.


Letter: Thrush.

Letter: Thrush.


Coronary heart disease in Papua New Guinea: present and future.


The influence of the balanoglossus chord on vital capacity of giant nerve cells in diffusion chambers.


Letters: Vagal stimulation and the left ventricular pressure in the rat.


Immunological defence mechanisms and immuno-suppressive therapy in rheumatoid arthritis.


Clinical experience with osmic acid in the treatment of joint effusion in rheumatoid arthritis. Preliminary report of a controlled clinical trial.


Non-surgical synovectomy in rheumatoid arthritis. Results obtained by radio-synoviorthesis.


Gastric mucosal injury by anti-inflammatory drugs.


Prostaglandins and inflammation.

Prostaglandins and inflammation.


Interaction and interference of some non-steroid anti-inflammatory drugs in man.


Lymphokines in the rheumatoid joint.

Lymphokines in the rheumatoid joint.


Immunosuppressive drugs in rheumatoid arthritis: clinical results.


The toxicology, absorption and pharmacokinetics of amoxicillin.


In vivo activity of amoxicillin.

In vivo activity of amoxicillin.


Amoxicillin in the treatment of lower respiratory infections.


Ten years of cephalosporins.

Ten years of cephalosporins.


Short-term radiorespirometry of cell suspensions. 1. An apparatus and method are described with which the oxidation of labelled substrates to (14)CO(2) by cell suspensions may be examined. 2. The use of high-specific-radioactivity substrates at low concentration together with frequent quantitative collection of CO(2) permit a more detailed analysis of the appearance of various substrate carbon atoms as CO(2) than is possible by existing techniques. 3. Typical experiments with various cell types are reported, in which pathways of glucose oxidation are examined.


Studies on the antigenic structure of Eikenella corrodens.


Early changes in the messenger ribonucleic acid concentration of amino acid-starved cells of Escherichia coli are not dependent on the state of the rel gene. Measurements of the concentration of mRNA in rel(+) and rel(-) strains of Escherichia coli shortly after the imposition of amino acid deprivation indicate that there is a temporary fall in the amount of this fraction relative to the total cellular RNA.


Learning to care for the mentally handicapped.


Through a glass darkly. (The development of needle aspiration biopsy).


Approach to a combined pharmacologic therapy of childhood hyperkinesis. The pharmacologic management of childhood hyperkinesis with psychostimulants has repeatedly proved its efficacy. In the case of hyperkinesis with an organic background (with eviden electrocencephalographic signs), the association with different anticonvulsants is usually beneficial although at times it gives rise to exceptionally undesirable side-effects, or to a paradoxically depressant action of the psychic activity. A clinical trial was carried out in 30 children aged from 5 10 years, with 2-dimethylaminoethanol in association with a magnesium salt of dipropylacetic acid (DAP).


Antigens of carcinoma of the cervix uteri. A study by means of immunofluorescence.


Antilymphocyte antibody purified by immunoabsorption and elution.


The mitogenic response of human B lymphocytes to phytohaemagglutinin.


The relationship between the immunoglobulin class of B-cell precursors and the degree of synergism obtained from the presence of T cells.


Identification of derepressed autoimmunocompetent B lymphoid cells in NZB mice.


Precipitins to Candida albicans in chronic mucocutaneous candidiasis studied by crossed immunoelectrophoresis with intermediate gel. Correlation with clinical and immunological findings.


The occurrence of autoantibodies in infectious mononucleosis.


Local production of immunoglobulin in the thyroid gland of obese strain (OS) chickens.


A study of the humoral immune response to osteoarticular allografts in the sheep.


Cell-mediated immune response following natural rubella and rubella vaccination.


International reference preparation for human serum IgG, IgA, IgM.


Acceptability of injectable contraception in the philippines.


"Prostaglandin impact" for menstrual induction.


Condom. An old method meets a new social need.


Contribution to the quantitative evaluation of the sensory nerve endings in human labium minus pudendi.


The modern condom--a quality product for effective contraception.


New medicines; potency, selectivity and the pill.


Circannual reproductive rhythms in mammals related to photoperiod and pineal function: a review.


Some aspects of circadian variations of carbohydrate metabolism and related hormones in man.


Non-specific uterine infection and bovine fertility. I. Infection patterns and endometritis during the first seven weeks post-partum.


Pattern of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in bovine blood plasma after injection of a synthetic gonadotropin-releasing hormone (Gn-RH).


Some observations on Corynebacterium pyogenes infection of the bovine uterus.


Release of LH after administration of an analog of synthetic LH-RH in cattle.


Enzymes in Wuchereia bancrofti.

Enzymes in Wuchereia bancrofti.


Exploration of a chemical index in place of coliform count as an indicator of water pollution.


Cancer epidemiology in India: a critique.


Anthropozoonotic helminthiases in Australia: the role of animals in disease transmission. Part 1:- Meat and offal-borne anthropozoonoses.


Anthropozoonotic helminthiases in Australia: the role of animals in disease transmission. Part 2:- Anthropozoonoses associated with domesticated and domiciliated vertebrates.


Parasitic zoonoses in Spain.

Parasitic zoonoses in Spain.


Studies on intrauterine contraceptive device of different material (II) endometerial histology.


Characterization of Mycobacterium lepraemurium cultured in NC-5 medium.


A new approach to the development of anti-cancer agents-5-FU derivatives.


Inherited disorders of the skin and skin diseases due to a hereditary predisposition.


Experimental contact dermatitis in mice.


Induction of contact sensitivity by epidermal microsomes dinitrophenylated in vitro.


Comparative studies on phototoxicity of chemicals.


Studies on photosensitivity caused by sulfa drugs. Part 6. Sensitization with p-hydroxylaminobenzene sulfonamide and histamine metabolism.


The (hi)story of the induction of molecular asymmetry by the intrinsic asymmetry in beta-decay.


Social determinants of the onset of puberty in rodents.


Education and Mental Health. General statement and analysis.


Computer-managed instruction in nursing.


Verapamil and the myocardium.

Verapamil and the myocardium.


Social class and mental disorder.

Social class and mental disorder.


Comparative clinical trial of diazepam with other conventional drugs in tetanus.


Annual review of surgery 1973.

Annual review of surgery 1973.


Morphological changes induced by wall inhibitors in pyogenic cocci.


The innervation of the hypothalamic median eminence.


[Microbiologic findings in a controlled trial of rifampicin and tetracycline for the treatment of severe endemic trachoma in Tunisia].


Modifications of the antral gastrin stores under sham-feeding stimulation.


The action of hyperthermia upon gastric secretion and upon some plasmatic electrolytes in rats.


Measurement of ocular blood flow.

Measurement of ocular blood flow.


Experimental and clinical study of factors influencing choroidal blood flow.


Cataract extraction with trabeculectomy.


A rationalization of treatment of central retinal artery occlusion.


Immunogenic uveitis. Wherein it is demonstrated that the cure may sometimes be worse than the disease.


Discrete colliquative keratopathy nutritional or phlyctenular?


Reassessment of idoxuridine therapy of herpetic keratitis.


Double-blind trial of Atromid-S in exudative diabetic retinopathy.


Ethamsylate (Dicynene) in cataract surgery. A double-blind clinical trial.


Effect of ethamsylate on blood loss during cataract surgery.


The causes, mechanisms and prevention of the high pressure nervous syndrome.


General history of vestibular disorders in diving.


Liquid breathing.

Liquid breathing.


Annual Oration on British Medicine and the Medical Society of London in May 1874.


Lettsomian lectures. Mondays, February 11th and 25th, 1974. Urinary infection.


Dr. Lettsom's Letters.

Dr. Lettsom's Letters.


The history of the Medical Society of London.


Some of the rarer books in the collection of the Medical Society of London.


Lloyd Roberts Lecture. Tuesday, November 27th, 1973. Medicine, philosophy and politics in the century of the renaissance.


Immunosuppression.

Immunosuppression.


Medical ophthalmology.

Medical ophthalmology.


Serum IgM immunoglobulin in neonatal enteritis. The serum IgM immunoglobulin level has been studied in 106 newborns admitted with enteritis of various aetiology. The clinical characteristics of E. coli K86 and K59 enteritis as well as those of aspecific enteritis are discussed. The epidemic caused by E. coli K86 was the first of its kind observed in Hungary. Mature, dysmature and preterm newborns were all capable of increased IgM production under the effect of an antigenic stimulus. Serial examinations showed a rapid and considerable rise of IgM concentration in the initial, active phase of the disease. The rise was significant statistically and the level remained constant in the course of the disease and during convalescence. The importance of prevention is emphasized, especially as fatal septicaemia may develop on the basis of the existing or of a new infection, in spite of careful nursing and drug therapy.


Excess IgD bearing lymphocytes in patients with malignant melanoma. B lymphocytes from the peripheral blood of 15 melanoma patients and 14 normal adults were studied using immunofluorescence to IgA, IgG, IgD and IgM surface markers. The total number of peripheral blood B lymphocytes was increased in the melanoma patients (1048/mm(3)) compared with normal controls (504) (P<0·01).The expression of excess IgD bearing lymphocytes in these melanoma patients may reflect a derepression of oncofoetal type.


Screening for polygenic disorders.

Screening for polygenic disorders.


Bronchodilators. Part II.

Bronchodilators. Part II.


Experimental cutaneous leishmaniasis. IV. Selective suppression of cell-mediated immunity during the response of guinea-pigs to infection with Leishmania enriettii.


The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation.


The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis.


The effect of a second dose of hycanthone alone and with progesterone caproate on the cure rate and the side reactions of hycanthone in the treatment of S. haematobium infected cases.


New aspects of the chemothrapy of bilharziasis with Ambilhar (Niridazole).


A review of the clinical pharmacology of hycanthone.


A short review of the epidemiology of schistosomiasis in Africa.


Cytogenetics of spontaneous abortions.

Cytogenetics of spontaneous abortions.


Pituitary response to LH-RH stimulation after testosterone treatment in normal men.


Sex and denture--psychological aspects.

Sex and denture--psychological aspects.


Renovascular hypertension after kidney transplantation.


The functional significance of the evolutionary divergence between the tryptophan operons of Escherichia coli and Salmonella typhimurium.


Therapy as applied utopian politics.

Therapy as applied utopian politics.


Aetiology of cardiomyopathy in Johannesburg Africans.


Virus and other infective forms of myocarditis in Southern Africa.


Idiopathic bundle branch fibrosis (IBBF): review of literature emphasizing relation to conduction system of other forms of primary cardiopathy.


In vitro and in vivo studies of the role of immune reactions in myocardial damage.


Incidence of cardiomyopathy.

Incidence of cardiomyopathy.


Heart transplantation in the treatment of cardiomyopathy.


Cardiomyopathies in England.

Cardiomyopathies in England.


Heart diseases of unknown etiology: problems of terminology and classification.


The international pilot study of schizophrenia.


An approach to the diagnosis and understanding of schizophrenia. Introduction.


The diagnosis and understanding of schizophrenia. Part II. Expanded perspectives for describing and comparing schizophrenic patients.


The diagnosis and understanding of schizophrenia. Summary and conclusions.


Topics in health care financing. Rate setting.


A tribute to Samuel X Radbill, M.D.

A tribute to Samuel X Radbill, M.D.


The evolution of child care in Scotland.


On the reading of medical classics.

On the reading of medical classics.


Medicine and pharmacy in French political prints.


A tenth-century physician prepares his medicines.


A meeting of two famous benefactors of the library of the University of Pennsylvania--Louis Adolphus Duhring and Theodore Dreiser.


The writing of American medical history before professionalization.


The anatomical lectures of William Shippen, 1766.


Dr. Henry Pickering Bowditch on the growth of children: an unappreciated classic study.


Charles David Spivak's role in the development of medical libraries.


William Osler: teacher.

William Osler: teacher.


The history of cardiology and the cardiac motif in ex libris.


Evolution of ribosomal proteins.

Evolution of ribosomal proteins.


Proteinchemical studies on proteins of bacterial ribosomes.


The fine-structural properties of the amino-terminal region of the 50S ribosomal "A" protein from Bacillus stearothermophilus.


Studies on ribosomal topography by analysis of specific ribonucleoprotein fragments.


Proteins at the peptidyltransferase center from E. coli ribosomes.


Identification by photoaffinity labeling of the proteins in E. coli ribosomes involved in elongation-factor G-dependent GDP binding.


Protein neighborhoods of the E. coli 30S ribosomal subunit.


Affinity labeling of the peptidyltransferase center of E. coli ribosomes.


A study of the structure of E. coli ribosomes by affinity labeling.


Affinity labeling of functional centers of E. coli ribosomes.


Functional interactions of E. coli 50S ribosomal proteins.


Ribosome-membrane interaction.

Ribosome-membrane interaction.


Comparative studies on the secondary structure of ribosomal RNA from rat liver, yeast and E. coli.


Pyrimidine rich surface of ribosomes.

Pyrimidine rich surface of ribosomes.


Peptide-chain initiation activity of yeast ribosomal wash fraction.


Studies on the androgen dependence of ribosome function in rat seminal vesicle.


Involvement of phospholipids in the multiple forms of eukaryotic elongation factor 1.


Translation of globin mRNA among eukaryotic and prokaryotic organisms.


Biosynthesis of proinsulin of carp (Cyprinus carpio).


Report on 45-month treatment of parkinsonism with L-dopa, alone and in association with a decarboxilase inhibitor (Ro 4-4602).


Reaction of human smooth muscle antibody with thyroid cells.


Technical study of the leucocyte migration inhibition test in agarose. Application to PPD and to hepatitis B antigen.


Clinical trial of clomiphene in advanced breast cancer.


Roster of members 1975. Nebraska Dental Association.


Pathologist's corner.

Pathologist's corner.


Replication of Escherichia coli requires DNA polymerase I.


Mutagenicity of chromates in bacteria and its relevance to chromate carcinogenesis.


Affinity labelling the acceptor site of the peptidyl transferase centre of the Escherichia coli ribosome.


Progressive myoclonic epilepsy. The response to sodium di -- n -- propylacetate.


Obituary: Dr. Brian Baxter Turner.

Obituary: Dr. Brian Baxter Turner.


Demyelination in the central nervous system of the cat studied by single fibre isolation.


Application of lysozyme and immunization with Escherichia coli 086 antigen in mice treated with 6-mercaptopurine.


Regulation of bacterial growth.

Regulation of bacterial growth. Is the control of bacterial metabolism so complex? The answer can be found in a simple experiment. Two cultures of bacteria are grown in different mediums. One contains as the carbon and nitrogen sources a mixture of amino acids, while the other contains only glucose and ammonia, so that the cells must synthesize all of the amino acids. The results show that insofar as the cells in both cultures grow at comparable rates, they will have the same composition in terms of DNA, RNA, and protein (30). To explain this phenomena I have argued that through the control mechanisms responsible for the distribution of substrates in intermediary metabolism, the substrates of protein synthesis are produced at concentrations and rates commensurate with the ability of the environment to support growth. The provision of these substrates relative to the ability of the protein forming system to utilize them regulates the synthesis of ribosomal and transfer RNA, which, after adjustment for various modulating influences, such as nonfunctioning ribosomes or ribosomal RNA turnover, brings the number of functioning ribosomes to a point in keeping with the provision of external nutrients. The synthesis of messenger (or total) RNA, ribosomal proteins, and DNA, and the process of cell division, for example, are subject to their own controls, but through the burden they each place on intermediary metabolism, they provide a means for partitioning the cell's metabolic resources. It might be noted that this view may not be very far from the idea once held that the rate at which each of the transfer RNA's was changed by amino acids regulate the synthesis of bacterial RNA, but growth regulation is clearly more complicated than implied by that model (76).


Letter: Creutzfeldt-Jakob disease: hypothesis for high incidence in Libyan Jews in Israel.


Transport studies in bacterial membrane vesicles. The use of bacterial membrane vesicles as an experimental system for the study of active transport has been discussed. Vesicles are prepared from osmotically sensitized bacteria, and consist of osmotically intact, membranebound sacs without internal structure. They retain litle or no cytoplasm. Under appropriate conditions, these vesicles catalyze the transport of a variety of solutes at rates which are comparable, in many cases, to those of intact cells. Two general types of transport systems have been elucidated in the vesicle system: (i) group translocation systems which catalyze vectorial covalent reactions; and (ii) respirationlinked transport systems that catalyze the active transport of a whole range of metabolites against an electrochemical or osmotic gradient. In E. coli membrane vesicles, the respiration-linked transport systems are coupled primarily to the oxidation of (D)-lactate to pyruvate, catalyzed by a flavin-linked, membrane-bound (D)-lactate dehydrogenase which has been purified to homogeneity. Electrons derived from (D)-lactate or certain artificial electron donors are transferred to oxygen by means of a membrane-bound respiratory chain, and respiration is coupled to active transport within a segment of the respiratory chain between the primary dehydrogenase and cytochrome. b(l). The great majority of the individual membrane vesicles in the population catalyze active transport, and the generation or hydtolysis of ATP is not involved. Under anaerobic conditions, fumarate or nitrate can be utilized in place of oxygen as terminal electron acceptors. With the exception that (D)-lactate is not always the most effective electron donor for active transport, vesicles prepared from a number of other organisms catalyze transport in a similar manner. Fluorescent dansylgalactosides are useful molecular probes of active transport in the vesicle system. These compounds are competitive inhibitors of beta-galactoside transport, but are not transported themselves. Fluorescence studies indicate that the lac carrier protein constitutes approximately 3 to 6 percent of the total membrane protein, and that it is not accessible to the external medium unless the membrane is "energized." Thus, energy is coupled to one of the initial steps in the transport process. Studies with a photoaffinity-labeled galactoside provide independent support for this conclusion. When membrane vesicles prepared from a (D)-lactate dehydrogenase mutant of E. coli are treated with (D)-lactate dehydrogenase, the enzyme binds to the vesicles and they regain the capacity to catalyze (D)-lactate oxidation and (D)-lactate-dependent active transport. The maximal specific transport activity obtained in the reconstituted system is similar in magnitude to that of wildtype vesicles. Titration studies with dansylgalactoside demonstrate that there is at least a seven- to eightfold excess of lac carrier protein relative to (D)-lactate dehydrogenase. Evidence is presented indicating that the enzyme is bound to the inner surface of native membrane vesicles and to the outer surface of reconstituted vesicles, and that the flavin coenzyme moiety is critically involved in binding. Possible mechanisms of respirationlinked active transport are discussed.


Multienzyme systems of DNA replication.

Multienzyme systems of DNA replication. Replication is accomplished by multienzyme systems whose operations are usefully considered in respect to three stages of the process: initiation, elongation, anid termination. 1) Initiation entails synthesis of a short RNA fragment that serves as primer for the elongation step of DNA synthesis. This stage, probed by SS phage DNA templates, reveals three distinctive and highly specific systems in E. coli. The Ml3 DNA utilizes RNA polymerase in a manner that may reflect how plasmid elements are replicated in the cell. The ØX174 DNA does not rely on RNA-polymerase, but requires instead five distinctive proteins which may belong to an apparatus for initiating a host chromosome replication cycle at the origin. The G4 DNA, also independent of RNA polymerase, needs simply the dnaG protein for its distinctive initiation and may thus resemble the system that initiates the replication fragments at the nascent growing fork. In each case it is essential that in vitro the DNA-unwinding protein coat the viral DNA and influence its structure. 2) Elongation is achieved in every case by the multisubunit, holoenzyme form of DNA polymerase III. Copolymerase III, which is an enzyme subunit, and adenosine triphosphate are required to form a proper complex with the primer template but appear dispensable for the ensuing chain growth by DNA polymerase (33). 3) Termination requires excision of the RNA priming fragment, filling of gaps and sealing of interruptions to produce a covalently intact phosphodiester backbone. DNA polymerase I has the capacity for excision and gapfilling and DNA ligase is required for sealing. What once appeared to be a simple DNA polymerase-mediated conversion of a single-strand to a duplex circle (34) is now seen as a complex series of events in which diverse multienzyme systems function. Annoyance with the difficulties in resolving and reconstituting these systems is tempered by the conviction that these are the very systems used ,by the cell in replicating its chromosome and extrachromosomal elements. Thus, understanding of the regulation of replication events in the cell, their localization at membrane surfaces and integration with cell division, and their coordination with phage DNA maturation and particle assembly will all be advanced by knowledge of the components of the replicative machinery.


Virginia dental Medicaid.

Virginia dental Medicaid.


Copyright: its adequacy in technological societies. What the United States does about the data explosion is likely to be copied on a global basis. America is the archetype of the coming technological society; we have all the advantages of being first, but others may avoid our mistakes. Let us hope that our errors are few


The successful internal splinting of a molar with a severe vertical fracture involving the pulp and periodontium.


Portrait. An individual profile.

Portrait. An individual profile.


Immunological aspects of chronic pyelonephritis. Cellular immune response in chronic pyelonephritis.


Experimental implantation of porous materials into bone. Proplast for low modulus fixation of prostheses.


Modelling of neural associative memory.

Modelling of neural associative memory.


Computer estimation of stroke volume from aortic pulse contour in dogs and humans.


Is there a place for wall reinforcement in modern aortic surgery?


Kidney transplantation in a community hospital.


Transfer RNA: evidence for decreasing size variation during evolution.


Translational control of protein synthesis by tRNA unrelated to changes in tRNA concentration.


A comparative study on the immunogenicity of live and inactivated Salmonella typhimurium vaccines in mice.


The diagnosis of bovine mastitis with particular reference to subclinical mastitis: a critical review of relevant literature.


Stimulation of the immune response in vivo by different nucleic acids.


Measurement of platelet aggregation in flowing blood with the use of a filter.


Kinetics of platelets of various densities in five thrombocytemic patients. (A study with 75 Se selenomethionine).


Dominant inherited familial factor VIII deficiency (Von Willebrand disease) associated with thrombocytopathic thrombocytopaenia. (Biologic and genetic implications).


The MRC trachoma unit a review of its researches, 1956-1973.


Muramidase in sera and urine of patients after kidney transplantation.


First Navy physician in space.

First Navy physician in space.


Pathology societies honor Dr. Hartman.

Pathology societies honor Dr. Hartman.


Hospital corpsmen honored for outstanding service.


On the road with Doc.

On the road with Doc.


RAdm Etter adieu.

RAdm Etter adieu.


The Deputy Chief David Paul Osborne.

The Deputy Chief David Paul Osborne.


The Navy Dental Corps: proud heritage and service.


The non-Hodgkin's lymphomas.

The non-Hodgkin's lymphomas.


History of retiree and dependent medical care in the US Navy.


Study of the use of arthrography.

Study of the use of arthrography.


A study of the methods of radiographic diagnosis of dental caries in epidemiological investigations.


Dentistry's mission: Possible or impossible. Hayden-Harris Memorial Lecture.


Our heritage.

Our heritage.


Effect of ageing on insulin and growth hormone response to glucose and arginine in normal subjects.


Dr. Ernest B. Nuttall distinguished alumnus for 1973.


Investigations on isolated islets in vitro. IX. Influence of food deprivation and glucose refeeding in vitro on insulin secretion.


Tolbutamide and practolol.

Tolbutamide and practolol.


Survival of Mycobacterium leprae in newborn rat heart cell culture.


Q--congenital hemidysplasia with ichthyosis.


Ocular response and soft lens wear: a review.


Amniocentesis.

Amniocentesis.


The value of plasma estrogen estimations in the management of pregnancy.


The value of biochemical estimations on amniotic fluid in management of the high-risk pregnancy.


Diabetes mellitus in pregnancy.

Diabetes mellitus in pregnancy.


The management of sickle cell disease in pregnancy.


The management of tuberculosis during pregnancy.


The current status of therapy in urinary tract infection in pregnancy.


Possible radiologic approaches to fetal diagnosis and therapy.


Delayed disease as a consequence of fetal exposure to radiation, infection, and exogenous hormones.


Obstetric anesthesia as a neonatal risk factor in normal labor and delivery.


Anemia in pregnancy.

Anemia in pregnancy.


Evidence for anterior hypothalamic control of cyclic gonadotrophin secretion in female pigs.


Editorial: Kellersberger Memorial Lecture.


Study of the immunity status against standard and locally isolated influenza strains in Egypt.


Who's hysterical?

Who's hysterical?


The mutation rate in man.

The mutation rate in man.


Approaches to the control and prevention of Tay-Sachs disease. A prototype Tay-Sachs disease prevention program is presented and di scussed.  The program strategy, design, and methodology are reviewed and results and analyses of epidemiologic data, testing results, and in-prog ram evaluations of the testing method are given, along with overall program results.  Psychosocial, genetic, and socioeconomic consideration s in the counseling of screenees and relatives of carriers are discussed.  In the 1st year of the program, 11 couples, none of whom had previously had a Tay-Sachs child, were identified to be at risk for Tay-Sachs disease in their offspring.


Biochemical polymorphisms in animals as models for man.


Ethical issues in genetics.

Ethical issues in genetics.


In memoriam. Enea Giuseppe Scolari.

In memoriam. Enea Giuseppe Scolari.


Inborn errors of the thyroid.

Inborn errors of the thyroid.


Thiamphenicol: use in a developing country. Part II: clinical trial of thiamphenicol in gonorrhoea "traitement minute".


A sketch of Nelville Soule Hoff.

A sketch of Nelville Soule Hoff.


Allison W. Haidle--forgotten dental teacher.


Professor Novy--historical biography.

Professor Novy--historical biography.


Mark Twain and dentistry.

Mark Twain and dentistry.


The CAIDENT center--a pilot program in the teaching of dentistry.


An interview with Roy G. Hayward, class of 1911.


Dr. Albert J. Wildanger -- Flint's fifth dentist.


Four grand old alums.

Four grand old alums.


Dental library, circa 1897.

Dental library, circa 1897.


Percy C. Lowery--distinguished alumnus.

Percy C. Lowery--distinguished alumnus.


The School of Dentistry--1952-1971.

The School of Dentistry--1952-1971.


A contribution to the problem of true-to-life artery fixation with special reference to the visualisation of atherosclerotic initimal alterations.


A review of implant telemetry systems.

A review of implant telemetry systems.


Unit activity in the supraoptic and paraventricular nuclei--the effects of anaesthetics.


Obituary. Georgy Donatovitch Smirnov (1914-1973).


Obituary: Walter Rudolf Hess (1881-1973).


Lateral hypothalamic electrical stimulation: does it make animals 'hungry'?


In gerontology 57 years--and 85.

In gerontology 57 years--and 85.


A geriatric autobiographical sketch--second installment.


[Giulio Cesare Pupilli].

[Giulio Cesare Pupilli].


Utilization of biochemical screening panels in medicine.


Human myocardial infarction: Coronarogenic or noncoronarogenic coagulation necrosis?


Study of infarcted myocardial tissue with fluoresceinated anti-haptoglobin and anti-orosomucoid [alpha1-acid glycoprotein] sera.


Toxicology of fluorides.

Toxicology of fluorides.


Fluoride metabolism.

Fluoride metabolism.


Proceedings: Recurrent glomerulonephritis.


Proceedings: Beta-adrenergic blockers in the treatment of hypertension: experience with propranolol at the U.C.H. Ibadan, Nigeria.


Premedication with thalamonal.

Premedication with thalamonal.


Proceedings: Vaccination against cerebrospinal meningitis.


David James Bell. 1905-1972).

David James Bell. 1905-1972).


Bone and cartilage induction by malignant human epithelial cells.


Application of enzymic methods to the structural analysis of polysaccharides: part I.


New concepts of etiology and diagnosis of metabolic bone disease.


Introduction to acupuncture.

Introduction to acupuncture.


The role of odontogenic epithelium in oral neoplasia.


A short history of endodontics.

A short history of endodontics.


The new president of the American Academy of the History of Dentistry, J. Henry Clarke, B.S., D.M.D.


In memoriam Dr. J. Menizies Campbell.

In memoriam Dr. J. Menizies Campbell.


The evolution of professional ethics in American dentistry.


A bibliography of articles and other writings of Dr. J. Menzies Campbell.


Dentistry and postage stamps.

Dentistry and postage stamps.


Classics in dental history.

Classics in dental history.


DNA synthesis.

DNA synthesis.


Control of transcription in bacteria.

Control of transcription in bacteria.


Cutaneous pathology- a historical view.

Cutaneous pathology- a historical view.


The role of the skin and adjacent mucous membranes in host defense.


In vitro synthesis of paraproteins in pathological skin.


The effect of triiodothyronine in healing of deep dermal burns and marginal scars of skin grafts. A histologic study.


Zola Cooper Memorial Clinicopathological Seminar in Dermatology.


Resident and transient bacteria of the skin.


A comparison of the immunosuppressive effects of thiamphenicol and cyclophosphamide in the rat renal transplant model.


Stamping out dentistry.

Stamping out dentistry.


A Hong Kong Tuberculosis Treatment Services/Brompton Hospital/British Medical Research Council Investigation.


Intermittent chemotherapy of pulmonary tuberculosis using rifampicin and isoniazid for primary treatment: the influence of various factors on the frequency of side-effects.


Serum enzyme changes in patients receiving antituberculosis therapy with rifampicin or p-aminosalicylic acid, plus isoniazid and streptomycin.


Some curiosities of the literature of tuberculosis.


Ten mycobacterial pathogens.

Ten mycobacterial pathogens.


A controlled clinical trial of small daily doses of rifampicin in the prevention of adverse reactions to the drug in a once-weekly regimen of chemotherapy in Hong Kong: second report:-the results at 12 months.


Sensitive microbiological method for the detection of rifampicin in urine.


The isolation of M. kansasii and M. xenopi from water systems.


In memoriam: Dr. János Pórszász 1923-1974.


Anatomic malformations of the lower respiratory tract. Congenital anomalies of the lung have been recognized relatively recently, and as a group are less well understood than the birth defects in most other systems. From case reports and reviews, it appears that the vast majority of pulmonary malformations are not familial, although many occur in association with other anomalies.


Congenital and genetic skin disorders with tumor formation. There are a great number of genetic and congenital disorders with skin manifestations ("genodermatoses") with tumor formation. Some of these tumors are benign (hamartomas, in part) and others are malignant. There is a large group of heredodegenerative disorders with such complications as lymphosarcoma and leukemia. There are congenital tumors with malignancy developing. Lastly, there are the chromosomal abnormalities with skin manifestations and tumors, usually malignant. This will be an ever increasing field and the use of fibroblast and virus cultures will become more important in ascertaining the cause of malignancy.


Cystic diseases of the kidney: a perspective on medullary cystic disease. Fifty-two cases of adequately documented cystic disease of the renal medulla (CDRM) were selected from available literature and analyzed for hereditary mode, age at onset, and duration. In 17, recessively inherited disease appeared at 9.4+/- 1.6(SE) and lasted 7.2+/- 1.7 years while in 21, dominantly inherited disease appeared at 29.3 +/- 2.3 and lasted 2.4+/- 0.4 years. In 14 isolated cases similar data were intermediate. These findings support an hypothesis that at least two genotypes are responsible for the phenotypic expression of CDRM.


The normal embryologic development of the kidney: a basis for understanding structural abnormalities. The embryologic development of the metanephric kidney is a regulated and sequential growth process. The induction of the early precursors of the metanephric kidney (pronephros and mesonephric) are essential first steps for the later appearance of the metanephric kidney. The pathogenesis of cystic disease can now be reexamined in light of these unique but carefully programmed growth processes with the expectation that the specific nature of the several growth disorders responsible can be more clearly defined.


The pathology of the kidney in cystinosis. The etiology and pathogenesis of the variable glomerular, tubular and interstitial functional and anatomic abnormalities in the kidney in cystinosis are not known. The doctrine that the abnormalities are consequent to accumulation of crystals of cystine must be questioned. Not previously appreciated, the podocyte is notably affected in cystinosis.


Gambling man.

Gambling man.


Charles Willson Peale.

Charles Willson Peale.


Meet John Savage, D. D. S. Georgia dentist running for lieutenant governor.


Accurate crown--and--bridge impressions in half the time.


Meet Winfield C. Dunn, D.D.S. Governor of Tennessee.


Dentistry at the Smithsonian Institution.


Greene Vardiman Black: father of modern dentistry.


The legacy...Dr. Arthur Davenport Black.


David Burbank D.D.S. ...founder of Burbank, California.


EHP: history and objectives.

EHP: history and objectives.


Effects of exposure to microwaves: problems and perspectives. During the last 25 years, there has been a remarkable development and increase in the number of processes and devices that utilize or emit microwaves. Such devices are used in all sectors of our society for military, industrial, telecommunications, and consumer applications. Although there is information on biologic effects and potential hazard to man from exposure to microwaves, considerable confusion and misinformation has permeated not only the public press but also some scientific and technical publications. The purpose of this review is to place the available information on biologic effects of microwaves in proper perspective and to suggest approaches to future studies.


Biological effects of ingested asbestos: report and commentary.


Technique for the systematic examination of colon--rectum specimens.


Monocyte and macrophage reactions.

Monocyte and macrophage reactions.


Mycotoxins: toxicity, carcinogenicity, and the influence of various nutritional conditions. Toxicologic diseases of man and animals, associated with molds growing on foods, have been recognized for centuries. Only in recent years, however, have these mycotoxicoses received the attention of many laboratories and skilled scientists around the world in a broad inter-disciplinary effort. This review covers the literature on mycotoxicoses but centers on those about which most is known, particularly the diseases associated with metabolites elaborated by some strains of Aspergilli, Penicillia, Fusaria, Stachybotrys, and Claviceps. The ubiquitous nature of the aflatoxins, toxic metabolites produced by Aspergillus flavus, make them important to public health, especially since it is now known that certain areas of endemic liver disease coincide with consumption of aflatoxins and, often, malnutrition. The older disease of ergotism, the scourge of Europe for centuries, is considered in detail. Alimentary toxic aleukia, which has caused enormous suffering in Russian human and animal populations, is better understood as a result of relatively recent experimental investigations. Stachybotryotoxicosis, a disease previously considered to be of significance only to man has now been identified in domestic animals.Finally, Japanese studies have clearly revealed the hepatotoxicity of certain metabolites of Penicillium molds. Factors that influence susceptibility to mycotoxins and the hazards they present to man are also reviewed.


Environmental radiation and the lung.

Environmental radiation and the lung. Environmental sources of radioactive materials and their relation to lung doses and lung burdens are described. The approaches used and the problems encountered in estimating lung doses are illustrated. Exposure to radon daughter products is contrasted to exposure to plutonium as particular examples of the hazards associated with radioactive materials of different chemical and physical characteristics.


A health view of asbestos: an annotated literature collection--1960-1974.


Selenourea and colloidal selenium: their role in radioprotection and radiosensitization of enzyme and cellular systems. The effect of selenourea and of colloidal selenium on dilute aqueous solutions of the enzyme yeast alcoholdehydrogenase and on suspensions of E. coli B/r has been studied. Selenourea usually appears to protect meanwhile colloidal selenium radiosensitizes. The results are considered in terms of chemical stability of selenourea and of its free radical reactivity.