Quantitative relationship between surface EMG and intramuscular electromyographic activity in voluntary movement.


Some cortical connections of the Tegu lizard (Tupinambis teguixin).


Activation of amygdaloid neurones in reward, eating and drinking elicited by electrical stimulation of the brain.


Response properties of slowly adapting mechanoreceptors to temperature stimulation in cats.


The thalamically induced orienting response in chronic cats with mesodiencephalic lesions.


Response of cat cochlear nucleus neurons to frequency and amplitude modulated tones.


A parametric study of movement detection properties of neurons in the cat's superior colliculus.


The release of prostaglandin E 1  from micropipettes in vitro.


Short-term inhibition of macromolecular synthesis and androgen-induced sexual differentiation of the rat brain.


A correlation between changes in GABA metabolism and isonicotinic acid hydrazide-induced seizures.


Uptake of (1,2- 3 H)20 -hydroxypregn-4-en-3-one, (1,2- 3 H)corticosterone, and (6,7- 3 H)estradiol-17 by guinea pig brain and uterus: comparison with uptake of (1,2- 3 H)progesterone.


(1,2 3 H)progesterone uptake by guinea pig brain and uterus: differential localization, time-course of uptake and metabolism, and effects of age, sex, estrogen-priming and competing steroids.


An unusual sensory area in the cerebral neocortex of the bottlenose dolphin, Tursiops truncatus.


Single seizures cause no ultrastructural changes in brain.


Dual visual organization of polysensory cortex in the cat.


Cerebellar surface cooling influencing evoked activity in cortex and in interpositus nucleus.


Responses of neurones of interpositus nucleus to stimulation of the sensorimotor cortex.


Discharges of single motor units at voluntary contraction of abductor digiti minimi muscle in man.


Development of thermoregulation in ducklings.


Dental anomalies in coyotes from central Alberta.


Monogenetic trematodes from the Bay of Quinte area, Ontario. 3. Genera Actinocleidus, Cleidodiscus, Urocleidus, and Tetraoncus.


A histochemical study of the developing tibiotarsus in Malathion-treated chick embryos.


Monogenetic trematodes from the Bay of Quinte area, Ontario. IV. Genus Dactylogyrus Diesing, 1850, with provisional host-parasite and parasite-host lists.


Subunits of chromosomal DNA. I. Electron microscopic analysis of partially denatured DNA.


Do children believe TV?

Do children believe TV?


Robertsonian chromosomal variation and identification of metacentric chromosomes in feral mice.


Five days a week in a family setting.

Five days a week in a family setting.


Hemorrhagic shock.

Hemorrhagic shock.


Metaphase distribution of the mouse chromosomes.


Health start: the Maine story.

Health start: the Maine story.


Septic shock.

Septic shock.


Factors influencing survival in patient with severe lacticacidemia.


Helping local head start staff and parents plan their own program: the enabler model.


Clinical applications.

Clinical applications.


A re-evaluation of massive blood replacement.


Placing older children in adoptive homes.


New concepts in the administration of bank blood.


The oxygen dissociation curve and multiple transfusions of ACD blood.


An evaluation of central venous pressure monitoring.


Problems in blood coagulation.

Problems in blood coagulation.


Defenses of the lung.

Defenses of the lung.


Modelling of individual pharmacokinetics for computer-aided drug dosage.


Computer approaches to protein structure. V. Viewing models of proteins from the inside.


The sensitivity of exponentials and other curves to their parameters.


A computer interface for radioisotope data processing.


Ward information-management system--an evaluation.


Television-computer analysis of kinematics of human gait.


Interactive acquisition and analysis of discrete data.


A program for efficient integration of rate equations and least-squares fitting of chemical reaction data.


Using a dedicated small computer in conjunction with a time-shared system in a hospital intensive care unit.


Quantitative analysis of a class of biomedical images by an image processing system.


A new test statistic for the Kodlin-Standish drug surveillance model.


A method for systematic assessment of the relative prognostic significance of symptoms and signs in patients with a chronic disease. I. Description of model and selection of prognostically significant symptoms and signs.


Perspective on--public information, science, and the regulatory process.


Cigarette smoke in closed spaces.

Cigarette smoke in closed spaces.


Biomedical data resources: a limiting factor in analytic epidemiology.


A mathematical model of driver alertness.


Susceptibility to lead toxicity.

Susceptibility to lead toxicity.


Influence of observing strategies and stimulus variables on watchkeeping performances.


Adaptation to weight transformation in water.


Changes in the vibratory sensation threshold after exposure to powerful vibration.


Angular measurements of foot motion for application to the design of foot-pedals.


Effect of eccentric and concentric muscle conditioning on tension and electrical activity of human muscle.


Measurement of force perception in pushing trolleys.


A general survey of the walking habits of individuals.


Comments on 'assessment of isometric muscle contractions'.


Cat optic tract and geniculate unit responses corresponding to human visual masking effects.


Analysis of the response characteristics of optic tract and geniculate units and their mutual relationship.


The synaptic activation of neurones of the feline ventrolateral thalamic nucleus: possible cholinergic mechanisms.


Cutaneous mechanoreceptors influencing impulse discharges in cerebellar cortex. 3. In Purkynĕ cells by climbing fiber input.


Integration by Purkynĕ cells of mossy and climbing fiber inputs from cutaneous mechanoreceptors.


Lemniscal and extralemniscal thalamic lesions and tactile discrimination in the rat.


Investigation of the role of mitochondria in the cardiac contraction--relaxation cycle.


A method of determining the sequence of incorporation of monosaccharides in the synthesis of the branched oligosaccharide chain of a structural compound. The biosynthesis of Tay-Sachs ganglioside.


A regulatory mechanism for CO 2  assimilation in plant photosynthesis: activation of ribulose-1,5-diphosphate carboxylase by fructose 6-phosphate and deactivation by fructose 1,6-diphosphate.


Chromatographic stability of codon-specific seryl-tRNA's from avian and mammalian tissues and two cases of a specific variation.


Affinity chromatography: large-scale purification of the soluble oestradiol-17-  dehydrogenase of human placenta.


Perturbation of tryptophanyl fluorescence of bovine growth hormone.


Action of the neurotoxin  -N-oxalyl-L- , -diaminopropionic acid on glutamate metabolism of brain mitochondria.


A strong competitive peptide-inhibitor for leucine aminopeptidase.


Porcine luteinizing hormone. The amino acid sequence of the   subunit.


Inhibitory effect of erucylcarnitine on the oxidation of palmitate by rat heart mitochondria.


Chromatographic separation of rat liver ribonucleic acids as constituents of cytoplasmic ribonucloprotein complexes.


Glycoprotein biosynthesis: stimulation of galactose transfer from UDP-( 14 C) galactose into microsomal protein by cytidine 5'-diphosphocholine.


The position of an essential tyrosine residue in the polypeptide chain of aspartate transaminase.


A new intermediate in the reoxidation of reduced human ceruloplasmin.


The action of various lysozymes on chitopentaose.


The chicken myoglobin (Gallus gallus). A 47 residue N-terminal sequence.


Ligand-induced reversal of the Soret CD band of lamprey hemoglobin.


A phenotypic male with karyotype 45,X:45,X,ace+(?Yg--).


The rare "silent" allele P O  or P V  (P Vienna ) of human red cell acid phosphatase, typed in a second family.


Phenotype frequencies for four serum proteins in Afghanistan: two "new" albumin variants.


Lactate dehydrogenase isoenzymes in oocytes and unfertilized eggs of mammals.


46,XY--47,XY, 18+ mosaicism with a 23-year survival.


Genetic linkage relationships of the ADA and 6-PGD loci in "Humangenetik".


Further observations on a previously reported case of 4p--syndrome.


Oral immunization with L-forms of Vibrio cholerae in human volunteers. Oral administration of heat-inactivated lysates of Vibrio cholerae Ogawa L-forms elicited significantly high coproantibody, serum indirect hemagglutinating antibody, and vibriocidal antibody responses in human volunteers, against both homologous and heterologous subtypes of V. cholerae and V. El Tor. Five oral biweekly doses produced an adequate antibody response which persisted for at least 6 weeks after immunization. No untoward side effects were seen.


Uptake and killing of Mima polymorpha and Herellea vaginicola by the reticuloendothelial system of neonatally thymectomized nonwasted mice. Phagocytosis and killing of Mima polymorpha and Herellea vaginicola by the liver, lungs, spleen, and kidneys from neonatally thymectomized nonwasted mice and their sham-thymectomized litter mates were compared. The removal of M. polymorpha from blood by these organs, measured 2 and 4 hr after intravenous injection of bacteria, was not affected by thymectomy. Because significantly fewer viable organisms persisted in the liver, spleen, and kidneys, it is concluded that bacterial killing increased after thymectomy. Phagocytosis of M. polymorpha by peritoneal macrophages increased in thymectomized mice. Removal of H. vaginicola from the blood by the lungs was greater after thymectomy. Thymectomy did not affect the killing of H. vaginicola by the liver, spleen, lungs, or kidneys. Killing of H. vaginicola by the kidney was less than that by other organs, although this was not affected by thymectomy. Chronic reticuloendothelial stimulation associated with infection was not an adequate explanation for these findings because no wasting syndrome was encountered.


Tests for antibody- and cell-mediated hypersensitivity to trypanosome antigens in rabbits infected with Trypanosoma congolense. Rabbits infected with Trypanosoma congolense were tested for immediate and delayed-type hypersensitivity responses to parasite antigens. Positive skin-test reactions were exclusively of the Arthus type, as shown by sequential histological analyses which revealed that more than 90% of the infiltrating cells at 24 hr postinjection were polymorphonuclear neutrophils. Skin reactions could be elicited in normal rabbits by intradermal injection of trypanosome antigen-antibody complexes. The absence of cell-mediated hypersensitivity to trypanosome antigens in infected rabbits was demonstrated by skin tests and by migration inhibitory factor and skin reactive factor tests. The role of the immediate-type skin reaction to trypanosome antigens in the pathology of infection and the possibility of its utilization for diagnosis are discussed.


Mycoplasma-like organism, parasite of red blood cells of an amphibian, Hydromantes italicus (Spelerpes fuscus). In the present investigation we studied a parasite of red blood cells in the amphibian Hydromantes italicus. The parasite, a globular microorganism having a diameter of 0.25 to 0.3 mum, was found in large numbers in vacuoles of red blood cells. As seen by electron microscopy, it possesses no cell wall and has the morphological appearance of a mycoplasma. The parasite has great motility by mechanisms not yet elucidated. It is possible to transmit the infection experimentally from infected to healthy amphibians. Culture of the microorganism, named Chondrostagon haematicum, in artificial media has not yet been successful.


Etiology of chronic pneumonia in rats and a study of the experimental disease in mice. The lungs of conventional rats with chronic pneumonia contained Streptobacillus moniliformis and Mycoplasma pulmonis. These organisms singly and in combination failed to produce lung disease when inoculated into specific pathogen-free rats. On the other hand, diseased lung homogenate not containing cultivable organisms caused a chronic pneumonia when inoculated into specific pathogen-free rats. The organism involved was seen by electron microscopy and is morphologically indistinguishable from the grey lung agent of Andrewes and Glover and Nelson's enzootic bronchiectasis "virus." All of these agents have morphological and biological properties which indicate close relationship to the mycoplasmas. However, we failed to culture them either in tissue cultures or on inanimate media and conclude that a group of highly fastidious mycoplasma-like agents are a cause of chronic pneumonia in rodents.


Breast cancer.

Breast cancer.


Acute intestinal obstruction.

Acute intestinal obstruction.


Delayed rupture of the spleen.

Delayed rupture of the spleen.


Dacryocystorhinostomy. A report of 200 cases.


Anesthetic use of pentazocine.

Anesthetic use of pentazocine.


Management of supracondylar fracture of the humerus in children.


How to improve communications at international scientific meetings.


Musings on brain transplants.

Musings on brain transplants.


Colonic replacement for esophageal atresia.


Extradural hematoma of the anterior fossa.


Sympatheticoblastoma.

Sympatheticoblastoma.


The American Dietetic Association position paper on nutrition and aging.


Collective bargaining in the health care industry.


Integrated nutrition and food cost control by computer.


How do administrators and administrative dietitians perceive the chief dietitian?


Man-machine productivity of dishwashing operations in hospitals.


Effect of citric acid on frozen whole strawberries.


Philosophy and status of an educational program for public health nutritionist-dietitians.


Student reactions to an educational program for public health nutritionist-dietitians.


Psychosocial seminar for dietitians.

Psychosocial seminar for dietitians.


Sources of plasma 17alpha-hydroxyprogesterone in human pregnancy.


In vitro inhibition of pancreatic glucagon secretion by diphenylhydantoin.


Screening tests for congenital adrenal hyperplasia.


Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH.


Gonadal function in males with myotonic dystrophy.


Human prolactin and growth hormone release during surgery and other conditions of stress.


Metabolic clearance of progesterone in the menstrual cycle. To study the metabolic clearance rate (MCR) of progesterone in the normal female menstrual cycle and to estimate progesterone production rates from reported plasma concentration values, 21 normally menstruating women, 19-36 years old, were  tested during various stages of the menstrual cycle.  The MCR of progesterone as measured by the continuous infusion method was found to be 2510/day or 1512 1/day per sq. m, which is greater than the MCR in males, ovariectomized females, and pregnant women.  The conversion rate of 20 alpha-hydroxypregn-4-en-3-one/progesterone was 10.9%.  No relation was found between the day of the cycle and either the MCR or the conversion ratio, as measured in 3 women at 3 stages of the same menstrual cycle and in 3 women 3 times every other day at midcycle.  The MCR appears to be relatively constant throughout the cycle.  This experiment confirms a calculated progesterone production rate based on known plasma concentrations of .75-2.5 mg/day in the follicular phase and 15-50 mg/day in the luteal phase.


Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation.


The inhibitory effect of lithium on thyroid hormone release in both euthyroid and thyrotoxic patients.


Thyrotropin and PBI in radioiodine treated hyperthyroid patients.


Absence of hyperlipidemia in acromegaly.


Pituitary rsponsiveness to aqueous vasopressin in patients with congenital vasopressin-resistant diabetes insipidus.


Inhibitory effect of L-Dopa on GH release in acromegalic patients.


Specific re-innervation of limbs transplanted between segments in the cockroach, Periplaneta americana.


Spatial organization of respiratory neurones in the medulla of tench and goldfish.


The activity of lateral-line efferent neurones in stationary and swimming dogfish.


Electrophysiology and ionic movements in the central nervous system of the snail, Helix aspersa.


Lung-air-sac anatomy and respiratory pressures in the bird.


Electrical and mechanical properties of the red and white muscles in the silver carp.


Oxygen affinity and compensated hemolysis in hereditary spherocytosis.


Renal weight and content of lipids and phospholipid renin "preinhibitor" in rats with renal hypertension.


The inhibitory properties of plasma against activated plasma thromboplastin antecedent (factor XIa) in hereditary angioneurotic edema.


Immunologic studies of antihemophilic factor (AHF, factor VIII). IV. Radioimmunoassay of AHF antigen.


An inexpensive apparatus for making precise, continuous, complex gradients for column chromatography.


Measurement of glomerular filtration rate in small animals without urine collection.


Characterization of ribosomal precursor particles from HeLa cell nucleoli.


Involvement of hemin, a stimulatory fraction from ribosomes and a protein synthesis inhibitor in the regulation of hemoglobin synthesis.


Nuclear magnetic resonance study of lecithin-cholesterol interactions.


Structure of crystalline methyl-chymotrypsin.


Light scattering by cellulose. IV. Fibers with helical morphology.


Doctors, drugs, and the FDA.

Doctors, drugs, and the FDA. This communication is directed to obstetricians, to the Food and Drug Administration (FDA), and to those individuals who might want to impose possibly unnecessary external structures on the practice of medicine.  It is considered a positive that the patients of today are well informed and are more actively participating in therapeutic design.  There is more veto power on the part of the patient and more concern over the trained ability of the physician.  In the past physicians frequently made judgements individually, applying isolated and at times random standards for their decisions.  Such actions were inevitable in an era when neither pathogenesis nor treatment was well understood.  Now there is no excuse for such actions.  Communication is easy, journals are widely circulated, and there are numerous refresher seminars.  Increased specialization of knowledge has meant more corporate or group decisions for therapy.  Current trends will continue to offer both opportunities and responsibilities.  The opportunities are for better diffusion of knowledge, and the responsibility is to be informed.  There can be a high level national standard for medical practice.  As a beginning, the medical practice laws could use some uniform decisions.  The FDA needs to show more responsiveness to changing knowledge and increased willingness to reconsider indications and contraindications in the light of newer experience.  There is sufficient information available now to support the revocation of the approval of the use of diuretics in the management of human pregnancy.  Another role of the FDA is the approval of new substances or new uses of old substances.  The prostaglandins appear in this category, and the December 1972 issue will include the recent Brook Lodge Symposium on prostaglandins.  The individual physician requires journal articles, individual experience, and designed trials in order to make judgements on patients who may have some factors not accounted for by groupthink or regulations.


Retarded fetal growth in eclampsia.

Retarded fetal growth in eclampsia.


Diagnostic value of cytological examination in pre-eclampsia.


Early abortion without cervical dilation: pump or syringe aspiration.


Phagocytosis in invertebrates. II. The clearance of carbon particles by the clam, Tridacna maxima.


Reticuloendothelial function in immune-suppressed animals.


Purification of a reticuloendothelial system-depressing substance produced in shock.


Microangiographic study of the splenic arterial vascularization in the normal and leukemic rat spleen.


Comparison of the reticuloendothelial systems fo normal and lipid-treated BALB-C and C57BL-6 mice.


Malaria in woodcock and ruffed grouse in Maine.


Antler malformation produced by leg injury in white-tailed deer.


Injurious antler anomaly in a Rocky Mountain elk.


Scrotal hernia in a white-tailed deer.

Scrotal hernia in a white-tailed deer.


Naturally occurring squirrel fibroma with involvement of internal organs.


A myxoma virus epizootic in a brush rabbit population.


Rabies in an Eastern fox squirrel.

Rabies in an Eastern fox squirrel.


"Mucocytes" in the brain of a llama: a case report.


Needs, priorities and development of wildlife disease research in relation to agricultural development in Africa.


Multiple neoplasia in a captive jungle cat (Felis chaus)--thyroid adenocarcinoma, gastric adenocarcinoma, renal adenoma, and Sertoli cell tumor.


Meningeal worm (Parelaphostrongylus tenuis) infection in white-tailed deer in Oklahoma.


Transplacental transmission of Protostrongylus spp. in bighorn sheep.


Facial base plane of Formosan students.

Facial base plane of Formosan students.


Base line of the dental arch.

Base line of the dental arch.


An electron microscopical study of the muscle in congenital muscular dystrophy.


Toxicity of fatty ozonides and peroxides.


Cholesterol-cerebroside interaction: the role of  -hydroxy fatty acids.


Lipids of human myocardium.

Lipids of human myocardium.


Sulfated and nonsulfated bile acid in human serum.


Preparation and characterization of prostanoyl carnitine.


The distribution of some elements in predentine and dentine of rat incisors.


The effect of mild dehydration on one-hour creatinine clearance rates.


Influence of anabolic steroids on nitrogen balance in chronic peritoneal dialysis.


Experience with maintenance hemodialysis. I. Patient survival.


Increase in bone magnesium content in renal failure in man.


Loss of iron-dextran through cuprophane membrane of a disposable coil dialyser.


Accidental mass hypernatremia during hemodialysis. Simultaneous observation in six cases.


Rapprochement subphase of the separation-individuation process.


The only child.

The only child.


4-oxopyranoazoles and 4-oxopyranoazines.


Aggression and ghetto-reared American Negro children. Structural aspects of the theory of fusion-defusion.


The theory of cognitive residues: a new view of fantasy.


Rhythmic (hierarchical) versus serial structure in speech and other behavior.


Perception of rotation in depth: a process model.


Gregory's theory of illusions: some disconfirming evidence in the case of the Müller-Lyer illusion.


Comments on L. E. Krueger's "disconfirming evidence" of R. L. Gregory's theory of illusions.


Role of the hypothalamus in motivation: an examination of Valenstein's reexamination.


Hypoglycaemic release of gastrin in man.


Gastric emptying rate and acid secretion after truncal vagotomy and pyloroplasty for duodenal ulceration.


Gastrin and acid studies in the pouch dog. 1. The response to food and insulin hypoglycaemia.


Gastrin and acid studies in the pouch dog. II. Effect of truncal vagotomy on response to food and insulin hypoglycaemia.


The hypertensive gastroesophageal sphincter. A manometric and clinical study.


Occurrence and progression of gastritis in patients operated on for peptic ulcer.


Inhibition of fibrinolysis in extracorporeal pig liver perfusion.


Measurement of the anal sphincter strength by a simple method suitable for routine use.


Taurocholate metabolism in man.

Taurocholate metabolism in man.


Gastritis and acid secretion in patients with gastric ulcers and duodenal ulcers.


Evidence of a gastro-hepatic osmoregulation in humans and the influence of vagotomy on its activity.


Autonomous thyroid nodules in children.

Autonomous thyroid nodules in children.


Electrolyte-fluid distribution in acute uraemia with and without overhydration in the rabbit.


Report from Scandinavia.

Report from Scandinavia.


Should the FDA impose relative efficacy judgments?


Ligating the common hepatic artery for uncontrollable hemobilia.


Scleroderma of the esophagus.

Scleroderma of the esophagus.


Infantile asthma: early recognition and management.


Benign soft tissue lesions of the extremities.


Homing of lymphoid cells in the developing palatine tonsil of the rabbit. A morphological and experimental analysis.


Ultrastructural and histochemical observations on spermathecal gland of Dytiscus marginalis L. (Coleoptera).


Quantitative studies of the renal corpuscles. I. Intraglomerular, interglomerular and interfocal variation in the normal kidney.


Impairment of the lymphocyte response to phytohaemagglutinin in chickens with Marek's disease.


Electron microscopic identification of endocrine cells in the bronchial epithelium of human foetuses.


Quantitative studies on the decay of lymphoid cells during the development of casein-induced murine amyloidosis.


On mild degrees of fluorosis. 2. An experimental, 2-year-study of rats drinking distilled water containing 0,1 or 5 ppm F - .


Simultaneous epidermoid carcinoma in situ of the portio-cervix and the endometrium of the uterus.


Cytology by the filter imprint technique.


Ultrastructure of the alveolar wall in experimental paraquat poisoning.


A case of Crohn's disease of the colon associated with adenocarcinoma extending from cardia to the anus.


The chromosomal findings in seven human neurinomas and one neurosarcoma.


Studies on the lymphocytes in the intestinal epithelium of the chicken. 1. Ontogeny.


Studies on the lymphocytes in the intestinal epithelium of the chicken. 2. Kinetics.


Gel filtration of lignosulphonic acids and peptide-precipitating abilities of the separated fractions.


The sedimentation pattern of D-glucose-6-phosphate dehydrogenase from bovine fetal and adult erythrocytes.


Experimental studies on the formation of volatile nitrogen compounds induced by pseudomonas fragi in a synthetic medium with amino acids as source of nitrogen.


The effect of ethionine feeding on the retention of a single per os dose of methyl mercury on rat.


Secretion of iodine 131 in bull semen compared to blood plasma and blood corpuscles.


The language question.

The language question.


Language for the deaf according to Henry.


A perspective on higher education for the deaf. The college-age deaf student.


An experiment in post-secondary education for deaf people.


The Northridge plan for higher education of the deaf.


Racism within the deaf community.

Racism within the deaf community.


The Montana State University theatre of silence.


Variant angina: case reports and critique.


The effect of a pressurized environment (hyperbaric chamber) on pulmonary emphysema.


Megaloblastic anemia associated with erythroid hypoplasia.


Pheochromocytoma of the urinary bladder, with inconclusive chemical and pharmacologic tests.


Abnormal iron and water metabolism in acute intermittent porphyria with new morphologic findings.


Factitious hyposthenuria.

Factitious hyposthenuria.


Light and electron microscopic changes in the myocardium of influenza-infected turkeys. Virus isolation and titration, electrocardiography, enzyme assays and light and electron microscopic studies were undertaken in male turkeys infected with influenza A/turkey/Ontario/7732/66 virus to determine its potential role in the genesis of heart disease. Virus was isolated from the heart initially before a demonstrable viremia and terminally in declining serum viral titer. Virus was isolated from the heart muscle as early as 1 day postinoculation. Highest viral titers were found in the heart at 6 days postinoculation and coincided with maximum elevations of serum glutamic-oxalacetic transaminase and lactic acid dehydrogenase, microscopic lesions in the heart and cardiac arrhythmias. Microscopic lesions in the heart were first detected at 4 days postinoculation and consisted of disseminated areas of necrosis, focal myocarditis, pericarditis and endocarditis. Alterations in myocardial ultrastructure which followed viral infection included fragmentation and dissolution of myofibrils, dilation of the sarcotubular system, increase in membrane vesicle formation in the region of the endoplasmic reticulum, discontinuity of the sarcolemma, proliferation of mitochondrial population, swelling of mitochondria with separation and disruption of the cristae, and the presence of intramitochondrial and perinuclear densities.


Reactions of blood with nonbiologic surfaces. Ultrastructural and clotting studies with normal and coagulation factor deficient bloods. Interaction of normal and coagulation factor deficient bloods with glass, Teflon and silicone-coated glass surfaces have been studied. The morphology of the blood-surface interaction was observed by scanning electron microscopy. Activation of the intrinsic coagulation system and progression of these changes, monitored by use of the partial thromboplastin time test, were influenced by both the type of surface to which blood was exposed and the deficiencies of coagulation Factors I, VIII, IX, or XII. Deficiency of fibrinogen appears to enhance, minimally, activation of the coagulation sequences by test materials. However, deficiency of fibrinogen markedly reduces adhesion of platelets to foreign surfaces. Deficiency of Factor XII, but not of Factors VIII or IX, decreases platelet adhesion to nonbiologic surfaces but to a lesser extent than does deficiency of fibrinogen. Roughness of test surfaces appears to encourage cellular deposition from blood. An ex vivo model designed for screening materials for their compatibility with blood is described.


Undifferentiated intraperitoneal tumors induced by human adenovirus type 12 in hamsters. A single intraperitoneal inoculation of 0.01 ml of virus fluid, 10(3.5) to 10(4.5) TCID(50) HeLa cells/0.1 ml, was made in 12 newborn hamsters. From 28 to 96 days after the virus inoculation, all 12 hamsters developed multiple, multicentric tumors in the peritoneal cavity. Histopathologic observations on these abdominal tumors strongly suggest that the so-called adenovirus-typical undifferentiated neoplasm produced by intraperitoneal inoculation may originate in part from a neuronal precursor cell group destined for the myenteric plexus. A histochemical study has indicated no direct evidence that the intracytoplasmic basophilic corpuscle is comparable to that of the enterochromaffin pigment. A cytologic perusal under electron microscopy has merely suggested that the poorly differentiated tumor cells closely resemble those described in undifferentiated neurogenic tumors. The mechanism of selective susceptibility of certain neuronal precursor cells to adenovirus remains unanswered.


Pancreas acinar cell differentiation. VII. Autoradiographic demonstration of intracellular radioactivity with with S-adenosyl-L-(C 3 H 3 ) methionine. After rat pancreas anlagen were grown in an organ culture medium for 9 days and further incubated for 15, 30 or 60 minutes in media to which C(3)H(3)-Sadenosyl-L-methionine (C(3)H(3)-SAM) was added, autoradiography demonstrated radioactivity in the nucleolus, nucleus and cytoplasm of the acinar cell. Under similar circumstances, except that the anlagen were grown in a methionine-deficient (CD-MD) medium prior to incubation with C(3)H(3)-SAM, much greater concentrations of radioactivity were present in the nucleolus, nucleus and cytoplasm of the acinar cell than in the respective compartments of anlagen grown in control medium. The nucleolus showed the highest concentration of radioactivity in anlagen grown in either control or methionine-deficient medium. The nucleolus of the acinar cell of anlagen grown in CD-MD medium appeared to be the most undermethylated cellular compartment and was larger than the nucleolus of the acinar cell grown in the control CD medium, so it is possible that a deficient methylation of ribosomal RNA precursors led to a piling up of RNA in the nucleolus and a decrease in the flow of ribosomal precursors to the cytoplasm. Other substance might have been undermethylated and thereby have inhibited differentiation.


The posterior cervical lymph node in toxoplasmosis. Posterior cervical node enlargement is characteristic of clinical toxoplasmosis in adults. Lymph node biopsies from 37 patients, who were tested for toxoplasmosis by serologic and isolation studies, were examined. A characteristic pattern of sinus histiocytosis was seen in 17 of 18 posterior cervical nodes and in only 1 of 4 lymph nodes from other sites from patients with toxoplasmosis. The characteristic pattern was not seen in posterior cervical nodes or in lymph nodes from other sites from patients with other diseases. Lymphoma obscured the characteristic changes of toxoplasmosis in the posterior cervical nodes and other nodes of 5 patients with these coexisting diseases. Organisms were seen in tissue sections in only 2 instances. T gondii was isolated from mice in 14 of 17 attempts using nodes from patients with toxoplasmosis, but from none of 8 attempts using nodes from patients with other diseases.


Responses of the protein-deficient rabbit to staphylococcal bacteremia. Staphylococcal bacteremia was induced in two groups of rabbits that were pairfed high protein and protein deficient diets. Marked deviations in response were observed as a result of protein deficiency: a) blood clearance of S aureus was delayed; b) persistence and multiplication of bacteria in blood and tissues were pronounced; c) neutrophilic response was poor and transitory; d) mortality was very high and occurred very early and e) focal necrotizing lesions, rather than well-formed abscesses, were found in organs.


Animal model of human disease. Crigler-Najjar Syndrome. Animal model: hereditary nonhemolytic unconjugated hyperbilirubinemia in Gunn rats.


Patterns of vandalism during civil disorders as an indicator of selection of targets.


A theory of ethnic antagonism: the split labor market.


A specification of relationships between job complexity and powerlessness.


The immediate cardiovascular effects of Althesin (Glaxo CT 1341), a steroid induction agent, and thiopentone in man.


Blood levels of trichlorethylene during major surgery. A gas chromatographic study.


A survey of pre-operative fear.

A survey of pre-operative fear.


Intramuscular ketamine in a developing country. Experience in the British Solomon Islands.


The G-suit. Its use in emergency surgery for ruptured abdominal aortic aneurysm.


Pulmonary oedema following vertebral artery ligation.


Ophthalmic hyper-sensitivity to anaesthetic vapour.


A method of passing naso-gastric tube during anaesthesia in the newborn.


Modifications to Braun intravenous cannula.


Pre-mixed nitrous oxide-oxygen analgesia in the ambulance service.


Ketamine in paediatric ophthalmic practice.


Inhaled foreign body.

Inhaled foreign body.


Passage of a Ryle's tube.

Passage of a Ryle's tube.


Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard.


Detection and variable time kinetic determination of micro and submicrogram amounts of nitrilotriacetic acid.


Analysis of mixtures of aminopolycarboxylic acids by chemical kinetics. Parts per billion of nitrilotriacetic acid in water.


Natural history of rheumatoid cervical luxations.


Spontaneous recovery of the joint space in degenerative hip disease.


Ultrastructural characteristics of the synovial membrane in idiopathic haemochromatosis.


Sacroiliitis and ankylosing spondylitis in North American Indians.


Studies of a popliteal synovial fistula.


Repair of extensor pollicis longus using extensor pollicis brevis in rheumatoid arthritis.


Plasma lipid levels in gout.

Plasma lipid levels in gout.


Transport of intravenously-injected ferritin across the guinea-pig synovium.


Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose.


Failure of oral D-penicillamine to modify adjuvant arthritis or immune response in the rat.


Hand measurements in ankylosing spondylitis.


Total hip replacement using the Charnley prosthesis in inflammatory joint disease.


Penetration of ampicillin and cloxacillin into synovial fluid and the significance of protein binding on drug distribution.


Studies on the mode of action of non-steroid anti-inflammatory drugs.


Studies on leishmaniasis in Ethiopia. 3. Resting and breeding sites, flight behaviour, and seasonal abundance of Phlebotomus longipes (Diptera: Psychodidae).


Isolations of Simbu-group viruses in Ibadan, Nigeria 1964-69, including the new types Sango, Shamonda, Sabo and Shuni.


Infection of a mosquito cell line with human type 5 adenovirus.


Immunological studies in Schistosoma mansoni infection in St. Lucia.


Studies in schistosomiasis in Sierra Leone. II. Seasonal fluctuation in the population density of Bulinus (Physopsis) globosus and Bulinus forskalii in a schistosomiasis endemic town in Sierra Leone.


The influence of temperature on the biology of Biomphalaria glabrata (Say), intermediate host of Schistosoma mansoni on St. Lucia, West Indies.


Treatment of hookworm infection and other intestinal parasites with 1-tetramisole (Ketrax).


Experimental chemoprophylaxis against schistosomiasis. I. Introduction and rationale.


Ultrasonography. VI. Pseudotumors of the orbit.


Combined choroidal and retinal detachment.


Polymorphic trypanosome infection in a lion.


Rupture of the globe.

Rupture of the globe.


Blindness and meningeal carcinomatosis.

Blindness and meningeal carcinomatosis.


Multiple serous detachments of the retinal pigment epithelium. A stage of senile disciform macular degeneration.


Lacrimal sarcoidosis treated with corticosteroids.


The temporal field in chronic simple glaucoma.


A modified tarrsorhaphy technique.

A modified tarrsorhaphy technique.


A new method of evaluating lacrimal drainage.


Bulbar conjunctivo-chalasis.

Bulbar conjunctivo-chalasis.


Visceral larva migrans of the eye. Subretinal tube formation.


Topically applied steroids in corneal disease. II. The role of drug vehicle in stromal absorption of dexamethasone.


Osteonecrosis of metacarpal heads in systemic lupus erythematosus. Value of radiostrontium scintimetry in differential diagnosis.


Impaired renal tubular secretion of potassium, elevated sweat sodium chloride concentration and plasma inhibition of erythrocyte sodium outflux as complications of systemic lupus erythematosus.


Reankylosis of the hip joint in ankylosing spondylitis after total hip replacement.


Connective tissue activation. IV. Regulatory effects of antirheumatic drugs.


Cyclophosphamide-induced, nonhemorrhagic cystitis with abnormal bladder cells.


Nucleic acids spontaneously released by living frog auricles.


Biosynthetic studies of glycocalyx-bound glycoprotein and glycolipid components in isolated brush borders of the rabbit small intestine.


Rumalon and serum-free culture of chondrocytes.


The cyanogen bromide fragments of rabbit skeletal-muscle tropomyosin.


Possible adverse effect of phenoxybenzamine therapy in a patient with progressive systemic sclerosis.


Isoenzymes of acid phosphatase in human endometrium.


A phosphorylated light-chain component of myosin.


Lymphoma and azathioprine.

Lymphoma and azathioprine.


Cerebral atherosclerosis in Negroes and Caucasians.


A proteolytic fragment of 26000 molecular weight from the heavy-chain fraction of myosin.


Evaluation of atherosclerotic lesions in cerebral arteries by unaided visual estimation.


Effects of anion-exchange polymers on bile acid metabolism in the rat.


Subunit structure and biological activity of tropomyosin B from different muscle types.


Quaternary structure of oligomers with dihedral symmetry.


Formation and utilization of ketone bodies by tissues of the adult pigeon.


Effect of pyridinolcarbamate on rat adipose tissue free fatty acids.


Atherosclerosis in human populations.

Atherosclerosis in human populations.


The relation between calcium ion transport and adenylate cyclase activity in myocardial sarcoplasmic-reticulum preparations.


The formation of glucosides of isoflavones and of some other phenols by rabbit liver microsomal fractions. 1. Rabbit liver microsomal fractions in vitro effected the transfer of glucuronic acid from UDP-glucuronic acid to biochanin A, formononetin, daidzein, genistein and equol. Only monoglucuronides were formed. 2. The same isoflavones were converted into monoglucosides when UDP-[6-(3)H]glucose was substituted for UDP-glucuronic acid in the incubation medium in vitro. The glucosides were formed in much lesser yield than were the glucuronides. 3. The glucoside of genistein was identified as genistin (genistein 7-glucoside) by Sephadex chromatography and reverse isotope dilution. 4. The specificity of the glucuronyl- and glucosyl-transfer mechanisms was compared for a series of steroids and other phenols in addition to the isoflavones. It was concluded that separate transferases were responsible for the formation of the two types of glycosides.


Effect of reticulo-endothelial blockade and stimulation on hepatic mitochondrial and microsomal lipids and atherosclerosis in cholesterol-fed cockerels.


Dietary protein intake and skeletal-muscle protein metabolism in rats. Studies with salt-washed ribosomes and transfer factors. 1. Aspects of skeletal muscle protein synthesis in vitro were studied in young rats given a low-protein diet for up to 10 days and during re-feeding with an adequate diet. 2. Partially purified muscle transfer factors (transferases I and II), crude and purified (NH(4)Cl-washed) ribosomes and a pH5 enzyme fraction were prepared for this purpose. 3. A marked decrease in the capacity of crude ribosomes to carry out cell-free polypeptide synthesis occurred within 4 days of feeding the low-protein diet. 4. The capacity of salt-washed ribosomes to promote amino acid polymerization, in the presence of added transfer factors and aminoacyl-tRNA, was only slightly decreased by the dietary treatment. 5. However, the capacity of salt-washed ribosomes to bind (14)C-labelled aminoacyl-tRNA was decreased by feeding the low-protein diet. 6. The capacity of the pH5 enzyme fraction to promote amino acid incorporation in a complete cell-free system was decreased within 2 days of feeding the low-protein diet. There is no evidence that the change is associated with aminoacyl-tRNA synthetase or binding enzyme activities of the pH5 fractions. 7. These changes are discussed in relation to the diminished rate of protein synthesis in the intact muscle cell when rats are given a low-protein diet.


Arteriosclerosis in exotic mammals.

Arteriosclerosis in exotic mammals.


Microbial metabolism of pyridinium compounds. Radioisotope studies of the metabolic fat of 4-carboxy-1-methylpyridinium chloride. Extracts of Achromobacter D formed CO(2), methylamine, succinate and formate as metabolic end-products from N-methylisonicotinic acid (4-carboxy-1-methylpyridinium chloride). The origin of the CO(2) in the 4-carboxyl group and of the methylamine in the N-methyl group of N-methylisonicotinate was demonstrated with carboxyl-(14)C- and N-Me-(14)C-labelled substrates respectively. The carbon skeletons of formate and succinate were shown to arise from the C-2 and the C-3-C-6 atoms of the heterocyclic ring respectively by using N-methyl[2,3-(14)C(2)]isonicotinate. This result is consistent with ring cleavage by the organism between C-2 and C-3.


The three-dimensional structure of supercoiled deoxyribonucleic acid in solution. Evidence obtained from the angular distribution of scattered light. 1. The size and shape of superhelical double-stranded circular DNA from bacteriophage ØX174 were investigated by light-scattering. The molecular weight of the DNA is 3.17x10(6) and the root-mean-square radius is 103.5nm. 2. The light-scattering envelopes of various theoretical three-dimensional models for such DNA molecules were calculated by repetitive computational techniques, and the results were compared with the experimental findings. 3. It is concluded that the structure of supercoiled DNA containing -12 superhelical turns in buffer of I0.2 corresponds best to one of the more compact models for superhelix structure such as the branched model, and the commonly employed straight interwound superhelix model is incompatible with the experimental results, at the superhelix density found.


Effects of hypo- and hyper-thyroidism on liver composition, blood glucose, ketone bodies and insulin in the male rat. 1. Thyroidectomized rats injected daily with 0, 0.1, 2 or 25mug of l-thyroxine/100g body wt. were compared with intact controls. In plasma, the protein-bound iodine was decreased in the rats given the 0 or 0.1mug doses and increased in those given the 25mug dose. 2. Blood glucose decreased in those given 2mug and was augmented in those given 25mug, and ketone bodies were the same in all the groups. 3. Plasma insulin was lowest in the rats given the 0 or 0.1mug doses and was highest in those given the 2 or 25mug doses of thyroxine. 4. After 48h starvation, the decrease in blood glucose and increase in ketone bodies observed in all the groups was greatest in the group not supplemented with thyroxine. 5. Plasma insulin concentrations remained at the value for fed animals in the rats given the 25mug dose of thyroxine but decreased in the other groups. 6. In fed animals, concentrations of hepatic DNA P, citrate, total fatty acids and acetyl-CoA were similar in all the groups, and glycogen was low only in the rats given the 25mug dose of thyroxine. 7. After 48h starvation, liver DNA P, total fatty acids and acetyl-CoA increased in all the groups, except in the rats given the 25mug dose, where both total fatty acids and acetyl-CoA remained at the value for fed animals. Liver citrate did not change in the groups given the 0 or 25mug doses of thyroxine, but decreased in the other groups. 8. The results are discussed in relation to the regulation of intermediary metabolism in hypo- and hyper-thyroidism.


Characterization of a long-chain  14 C-labelled alcohol resulting from a plant enzyme-catalysed reaction with S-adenosyl(methyl- 14 C)methionine. A particulate enzyme from Phaseolus aureus seedlings catalyses the incorporation of radioactivity from S-adenosyl[Me-(14)C]methionine into several lipid acceptors present in the enzyme preparation. The structure of one of the radioactive lipids has been elucidated by using mass, n.m.r. and i.r. spectral data. This compound has a molecular formula C(28)H(57)OH, is a saturated primary alcohol and has a single branch of one methyl group in the interior of the hydrocarbon chain. The results of a Kuhn-Roth degradation demonstrate that the branch methyl group is the one derived from S-adenosylmethionine.


The transformation of the cytoplasmic oestradiol-receptor complex into the nuclear complex in a uterine cell-free system. Experiments performed with a cell-free system in tris-EDTA buffer, pH 7.4, indicate that the high-speed supernatant fraction of the rat uterus contains all the factors necessary to transform the 8S cytoplasmic oestradiol-receptor complex to the nuclear complex. The transformation is temperature-dependent. This nuclear complex was extracted in the form of a 5S particle with 0.4m-KCl from sediments of either uterine or heart nuclei that had been incubated together with the cytoplasmic soluble fraction of the uterus at 2 degrees C for 30min. This complex can also be obtained similarly from the soluble fraction of the uterus, incubated in the absence of nuclei. Previous warming of the soluble fraction to 37 degrees C for 7min was necessary for the successful extraction of the nuclear particle under these conditions of incubation. After an incubation of the transformed complex with the nuclear sediment at 37 degrees C for 7min, the 5S complex was extractable from the uterine nuclear sediment but not from the heart nuclear sediment, which may indicate the tissue specificity of the nuclear acceptor sites for the transformed complex. The extracted uterine nuclear complex sediments in the 5S region, but whether it is the native complex or a subunit or other part of the native complex resulting from the extraction with salt is unknown.


The effect of phenylpyruvate on pyruvate metabolism in rat brain. 1. The effect of phenylalanine and phenylpyruvate on the metabolism of pyruvate by isolated mitochondria from rat brain was investigated. 2. Phenylpyruvate inhibited the fixation of H(14)CO(3) (-) in the presence of pyruvate by intact rat brain mitochondria, whereas phenylalanine and other metabolites of this amino acid had no inhibitory effect on this process. 3. Pyruvate carboxylase activity in freeze-dried rat brain mitochondrial preparations was also inhibited only by phenylpyruvate, and a ;mixed type' inhibition was observed. 4. The K(m) for pyruvate of rat brain pyruvate carboxylase was about 0.2mm. 5. The concentration of phenylpyruvate required for a 50% inhibition of H(14)CO(3) (-) fixation by the intact mitochondria and of pyruvate carboxylase activity was dependent on the concentration of pyruvate used in the incubation medium. 6. The possible significance of inhibition of pyruvate carboxylase activity by phenylpyruvate in the brains of phenylketonuric patients is discussed.


Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids. 1. Amino acids, particularly glutamate, gamma-aminobutyrate, aspartate and glycine, were released from rat brain slices on incubation with protoveratrine (especially in a Ca(2+)-deficient medium) or with ouabain or in the absence of glucose. Release was partially or wholly suppressed by tetrodotoxin. 2. Tetrodotoxin did not affect the release of glutamine under various incubation conditions, nor did protoveratrine accelerate it. 3. Protoveratrine caused an increased rate of formation of glutamine in incubated brain slices. 4. Increased K(+) in the incubation medium caused release of gamma-aminobutyrate, the process being partly suppressed by tetrodotoxin. 5. Incubation of brain slices in a glucose-free medium led to increased production of aspartate and to diminished tissue contents of glutamates, glutamine and glycine. 6. Use of tetrodotoxin to suppress the release of amino acids from neurons in slices caused by the joint action of protoveratrine and ouabain (the latter being added to diminish reuptake of amino acids), it was shown that the major pools of glutamate, aspartate, glycine, serine and probably gamma-aminobutyrate are in the neurons. 7. The major pool of glutamine lies not in the neurons but in the glia. 8. The tricarboxylic cycle inhibitors, fluoroacetate and malonate, exerted different effects on amino acid contents in, and on amino acid release from, brain slices incubated in the presence of protoveratrine. Fluoroacetate (3mm) diminished the content of glutamine, increased that of glutamate and gamma-aminobutyrate and did not affect respiration. Malonate (2mm) diminished aspartate and gamma-aminobutyrate content, suppressed respiration and did not affect glutamine content. It is suggested that malonate acts mainly on the neurons, and that fluoroacetate acts mainly on the glia, at the concentrations quoted. 9. Glutamine was more effective than glutamate as a precursor of gamma-aminobutyrate. 10. It is suggested that glutamate released from neurons is partly taken up by glia and converted there into glutamine. This is returned to the neurons where it is hydrolysed and converted into glutamate and gamma-aminobutyrate.


The osmotic properties of sulphoethyl-sephadex. A model for cartilage. 1. Observations are reported on the variation of the swelling of sulphoethyl-Sephadex C-50 and C-25, and of the partition of NaCl between solution and gel, with the concentration of NaCl. 2. The results were interpreted in terms of Manning's (1969) treatment of the interactions between polyionic polymers and simple electrolytes and of Flory's (1953) treatment of the swelling of gels. 3. The results indicate net inner osmotic pressures as high as 3.6x10(5)Pa (140 mosmolar=3.6x10(5)N/m(2)) in 0.15m-NaCl. 4. It is suggested that cartilage may have net inner osmotic pressure of the order of 10(5)Pa.


The protective effect of oleate on metabolic changes produced by halothane in rat liver.


The oxidation of Schiff bases of pyridoxamine with  -oxo acids by manganous ions and peroxidase. 1. Oxygen was taken up rapidly when pyruvate was added to mixtures of pyridoxamine and Mn(2+) ions after lag periods that were shortened by peroxidase (donor-hydrogen peroxide oxidoreductase, EC 1.11.1.7). 2. The total oxygen uptake was proportional to the pyridoxamine added and was accompanied by the disappearance of pyridoxamine; the pyruvate acted catalytically and hydrogen peroxide was not formed. 3. At pH6 more than half the pyridoxamine that disappeared was accounted for as pyridoxal and ammonia; it is suggested that the primary reaction is the oxidative deamination of the pyridoxamine. 4. Results were similar when alpha-oxobutyrate or glyoxylate were substituted for pyruvate, except that the reactions were slower and the yield of pyridoxal less. 5. The oxidative decarboxylations of alpha-oxoglutarate and phenylpyruvate are catalysed by Mn(2+) ions and these reactions are activated by peroxidase; pyridoxamine increased both the rates and total oxygen uptakes in these reactions, and ammonia was produced. 6. The lag periods in the oxidation of mixtures of pyridoxamine and alpha-oxo acids, catalysed by Mn(2+) ions, were also shortened by traces of colloidal manganese dioxide. 7. It is suggested that the activating effect of peroxidase depends on its catalysis of manganese oxidation.


Preparation and properties of nexuses and lipid-enriched vesicles from mouse liver plasma membranes. Extraction of mouse liver plasma membranes with 4% (w/v) N-laurylsarcosinate-tris buffer, pH7.8, solubilized 80-90% of the protein and 60% of the 5'-nucleotidase activity. The membrane residue remaining after extraction was resolved on sucrose gradients into two fractions: a vesicular membrane fraction and a fraction characterized by the presence of large numbers of nexuses in an amorphous background. The vesicular fraction had a phospholipid/protein weight ratio of 7:1, it contained most of the plasma-membrane glycolipids, and polyacrylamide-gel electrophoresis indicated the presence of only five to eight proteins, including two or three glycoproteins. The 5'-nucleotidase and leucine naphthylamidase specific activities were 23- and 6-fold higher respectively than in the plasma membranes. Electron microscopy of thin sections and negatively stained preparations indicated that the nexuses present in the second fraction closely resembled gap junctions present in tissue sections and isolated plasma membranes. The nexus fraction contained a distinctive protein pattern, and of the 20 proteins present about four were identified as glycoproteins by Schiff-periodate staining. Examination of the lipid composition of the fractions by t.l.c. showed that in the nexus fraction, phospholipids and glycolipids were present in small amounts compared with triglycerides and cholesterol. Amino sugar analyses confirmed the t.l.c. results and amino acid analysis showed the fractions to have characteristic protein compositions. A ;reconstituted' membranous fraction prepared by dialysis against MgCl(2) of membrane components soluble in N-laurylsarcosinate-tris buffers, pH7.8, lacked the trilaminar image characteristic of the two other membrane fractions isolated and was devoid of enzyme activities. The results indicate that proteins and glycoproteins play an important role in the structural maintenance of the nexuses isolated from the liver by the present procedure.


Reaction of nitrosoureas with polycytidylate templates for ribonucleic acid polymerase.


The storage and release of acetylcholine.


Stimulation by cortisol and insulin of the 'ureotelic' arginase activity of chicken liver.


Regulatory significance of the release and action of adenine derivatives in cerebral systems.


Cellular control of the uptake, storage and release of catecholamines.


Measurement of the specific radioactivity of glutamine and glutamate in plasma.


The role of ketone bodies in the metabolism of the adult desert locust.


Cholesterol metabolism in rabbits with dietary-induced gall-stones.


Studies on glycolysis in the dog kidney in vivo.


Isolation of a fraction from rat cerebellum enriched in nerve terminals of one single type (mossy-fibre terminals).


The effect of electrical stimulation of the locus coeruleus on the endogenous concentration of 4-hydroxy-3-methoxy-phenylethylene glycol in rat brain.


Effects of diphenyleneiodonium and trialkyltin compounds on photophosphorylation and chloride-hydroxide exchange in isolated chloroplasts.


Oxidation of oxalate and formate by leaf peroxisomes.


Oxidative decarboxylation of glycollate and glyoxylate by leaf peroxisomes.


The occurrence of an induced glyoxylate cycle in wheat aleurone tissue.


A comparison of some properties of the 1,2-dihydroxynaphthalene oxygenase and catechol 2,3-oxygenase activities in naphthalene-grown pseudomonas sp. NCIB 9816.


The divergent meta-cleavage pathway for the metabolism of benzoate, 3-methylbenzoate and 4-methylbenzoate by Pseudomonas arvilla mt-2.


Different ribonucleic acid polymerase activities in larval and adult blowflies.


The use of (5-3H)uridine for pulse-labelling ribonucleic acid of mouse Ehrlich ascites-tumour cells.


Studies on the heterogeneity of mouse globin messenger ribonucleic acid.


A demonstration that embryonic mouse liver heterogenous nuclear ribonucleic acid contains globin messenger ribonucleic acid sequences.


The separation of two aldehyde reductases from pig brain.


The effects of catecholamines and methylxanthines on glucose utilization in isolated fat-cells derived from the rat.


Salt bonding in proteins. A model for the abnormal hydrogen ion titration and the strong anion binding of serum albumin.


The mechanism of phosphoglucomutase from Micrococcus lysodeikticus.


The pH dependence of tyrosine cyanuration in proteins.


The nucleic acid distribution function: evaluation of the loop closure probability.


Quasielastic light scattering investigation of the isothermal "helix to extended-coil" transition of poly-L-lysine HBr.


Study of the interaction of DNA and acridine orange by various optical methods.


Effect of temperature on the circular dichroism spectra of polypeptides in the extended state.


Effects of deuterium on the thermal stability of the poly A-poly U helix.


Complexes of histone F1 with DNA in 0.15M NaCl. Circular dichroism and structure of the complexes.


Renaturation of DNA in the presence of ethidium bromide.


Far from equilibrium synthesis of "prebiotic" polymers.


Rapid kinetic studies on the conformation of single-stranded DNA.


The simple construction of protein alpha-carbon models.


A summary of the National Halothane Study.


Halothane hepatitis as seen by the physician.


Methohexitone in the management of a disturbed patient. A case report.


Anaesthesia and sickle-cell haemoglobin. With a case report.


Foetal acid-base balance at Caesarean section.


Reaction to propanidid.

Reaction to propanidid.


A method of fixation of endotracheal tubes.


Thalamonal and cerebral circulation.

Thalamonal and cerebral circulation.


Do-it-yourself venting appliance for use with a popular expiratory valve.


Circulatory effects of controlled arterial hypotension with trimetaphan during nitrous oxide-halothane anaesthesia.


Blind nasal intubation with propanidid.

Blind nasal intubation with propanidid.


The risk of aspiration in presence of cuffed endotracheal tubes.


Geriatrics at the crossroads.

Geriatrics at the crossroads.


Organisation and program in a Geriatric Centre in Israel.


Refusal to participate in a survey of the elderly.


Ultrasound in the diagnosis of deep vein thrombosis in the elderly.


Cholesterol as a parameter of subnutrition in the elderly in-patient.


L-dopa in the treatment of parkinsonism.


Visual acuity in older people.

Visual acuity in older people.


X-ray and proton induced lens changes in the rabbit.


Radiation dose to the gastrointestinal tract of farm animals after ingestion of a fallout simulant.


Metabolic and therapeutic study following administration to rats of  238 Pu nitrate--a comparison with  239 Pu.


Dose distribution and maximum permissible burden of  125 I in the thyroid gland.


Effectiveness of DTPA for the removal of in vivo  144 Ce accompanied with different levels of carrier.


Tissue distribution of accumulated radionuclides in freshwater clams.


Fallout  137 Cs and  90 Sr in trout from mountain lakes in Colorado.


Relative shielding properties of ammonium metatungstate for neutrons and gamma rays from  252 Cf.


Dose outside useful beam in water and realistic phantoms exposed to chest radiographic procedures.


Plutonium-239 and americium-241 contamination in the Denver area.


Survey of medical radiation sources in Taiwan.


Mortality experience of uranium and nonuranium workers.


Memorial ionization chambers; construction and response.


FISP, a comprehensive computer program for generating fission product inventories.


Thorium daughters in the spleen of a thorotrast case.


Shielding of fast neutron cancer therapy sources.


Experimental determination of chord length distribution in cavities.


Thermoluminescence dating and the sensitization method.


A fast charger for nickel-cadmium batteries.


Sisters of Providence conduct opinion study at their 11 hospitals.


The role of the financial intermediary in building programs.


Theologians view the Directives.

Theologians view the Directives.


What's behind the legislative scene.

What's behind the legislative scene.


Corporate responsibility vs institutional autonomy.


Delivery systems--the institutional component.


The chemistry profile: an adjunct to patient care.


Oxygen-stable hemolysins of group A streptococci. 8. Leukotoxic and antiphagocytic effects of streptolysins S and O. Streptolysin S exists in a cell-bound form and as an extracellular complex between a nonspecific carrier (serum, serum albumin, ribonucleic acid [RNA], Triton, Tween) and a hemolytic moiety (probably a peptide) synthesized by streptococci. Although all the forms of streptolysin S, at 100 hemolytic units, killed mouse leukocyte monolayers, the time needed to kill 100% of the cells varied with the different streptolysin S preparations. Whereas 30 min was sufficient for the cell-bound hemolysin to kill all of the cells, 60 and 180 min were required when RNA streptolysin S and serum streptolysin S, respectively, were employed. Addition of 10% mouse serum to RNA streptolysin S or to cell-bound hemolysin delayed the killing of the leukocytes. The delayed killing observed with serum and albumin hemolysins is probably due to competition for the hemolytic moiety between the carrier molecules and target sites (phospholipids) upon the leukocyte membrane. Serum streptolysin S must be constantly incubated with the cells for 90 min for 100% of the cells to undergo cytopathic changes upon subsequent incubation for an additional 90 min. Streptolysin S inhibitor (trypan blue) added to the system after 30 or 60 min of incubation resulted in the killing of 50 and 100% of the leukocytes, respectively, when the cells were further incubated for 120 min. It is suggested that 30 min of incubation was not sufficient for the transfer of enough streptolysin S molecules upon the cell surface to allow killing of all of the cells. Sublethal amounts of streptolysin S, streptolysin O, and saponin suppressed phagocytosis of streptococci by mouse peritoneal macrophages. This effect was abolished by inhibitors of streptolysin S (trypan blue) and of streptolysin O and saponin (cholesterol). With sublethal amounts of streptolysin S, no inhibition of the reduction of nitro blue tetrazolium by nonphagocytosing cells was observed, but these amounts of streptolysin S caused a 50% inhibition of the reduction of nitro blue tetrazolium by phagocytosing leukocytes. It is suggested that some metabolic systems, which are normally enhanced during phagocytosis, have been affected by sublethal doses of streptolysin S. The results indicate that the in vivo production of small amounts of streptolysins S and O by group A streptococci may inhibit phagocytosis and may thus contribute to the invasiveness and pathogenicity of this microorganism.


Response of cultured mammalian cells to diphtheria toxin. IV. Isolation of KB cells resistant to diphtheria toxin. KB cell strains which are resistant to the lethal effects of diphtheria toxin were isolated from the toxin-sensitive KB cell line. For one such strain, KB-R2, the concentration of diphtheria toxin required to cause a 50% reduction of incorporation of amino acids into protein was more than 2,000 times that required in the sensitive KB-S cell. The KB-R2 strain was cloned by a single-cell isolation method to yield uniform strains with an even greater resistance to toxin. Resistance is a stable, inheritable property, providing a good genetic marker, and appears to be related to some alteration in the cell membrane. Preliminary studies showed that these cell strains are resistant to poliovirus and vesicular stomatitis virus as well as to toxin.


Neutralization of Staphylococcus aureus exfoliatin by antibody. Alum-precipitated exfoliatin was found to be an efficient antigen for eliciting high titers of neutralizing antibody in rabbits. Antitoxin thus produced, and transferred passively, was shown to protect neonatal mice against challenge with two to three lethal doses of preformed exfoliatin even when administration was delayed until 15 min before exfoliation began in control animals. The same dose of antitoxin afforded some protection against six to eight lethal doses of exfoliatin provided it was given before or at the time of challenge. Antitoxin, in the doses given, did not protect against infection with an exfoliatin-producing Staphylococcus aureus strain although the onset of exfoliation was delayed.


Tetrahydrotriamcinolone and triamcinolone. I. Ocular penetration.


Electron microscopy of the fetal development of the corneal endothelium and Descemet's membrane of the human eye.


Calcium-induced aggregation of bovine lens alpha crystallins.


Laser Doppler measurements of blood flow in capillary tubes and retinal arteries.


Relationship between the blood flow velocity in the ciliary body and the intraocular pressure of rabbit eyes.


Basophil degranulation: a new method of observation and its correlation with skin testing.


Diabetic residents of homes for the aged: observations for an eleven-year period.


Aortic resections in retrospect.

Aortic resections in retrospect.


Cerebral complications of ulcerated atheromata at the carotid bifurcation.


The exploratory laparotomy: case report.


Close correlation between extent of cardiac fibrosis and alterations in myocardial electrolyte content.


Secret remedies belong in museums.

Secret remedies belong in museums.


Autotherapy--"the future is now".

Autotherapy--"the future is now".


Will you be ready?

Will you be ready?


O-T-C feminine hygiene aids.

O-T-C feminine hygiene aids.


O-T-C sunscreen and suntan products.

O-T-C sunscreen and suntan products.


The change of stability and activity of thermolysin by acetylation with N-acetylimidazole.


Studies on luciferase from Photobacterium phosphoreum. II. Substrate specificity and stoichiometry of the reaction in vitro.


Studies on drug-induced lipidosis. VI. Identification and determination of the drug and its metabolite in lipidosis induced by 4,4'-diethylaminoethoxyhexestrol.


Effects of 2,4-substituents of deuterohemin upon peroxidase functions. I. Preparation and some properties of artificial enzymes.


Studies on the substrate specificity of Taka-amylase A. X. Change in the mode of substrate binding by p-phenylazobenzoylation of the enzyme.


Extrinsic cotton effects of fluorescein mercuric acetate conjugated with Bence Jones proteins.


Calorimetric studies on hydrolysis of glucosides. V. Heats of hydrolysis of cyclohexa-, cyclohepta-, and cyclooctaamyloses and thermodynamic considerations on the cyclization process.


Studies on disappearance of immunoglobulins from injected sites of skin and its relationship to passive cutaneous anaphylaxis.


Kinetic studies on the amine oxidase reaction.


Glutathione-dependent interconversion of microheterogeneous forms of glucose-6-phosphate dehydrogenase in rat liver.


Preparation of F-actin: Sepharose 4B matrix.


Digestive enzymes in insectivorous plants. IV. Enzymatic digestion of insects by Nepenthes secretion and Drosera peltata extract: proteolytic and chitinolytic activities.


Stimulatory effect of Na +  on threonine transport through bacterial cells.


The appearance of Forssman hapten in human tumor.


Separation of troponin into its three components.


Nuclear magnetic resonance titration curves of histidine ring protons. 3. Ribonuclease.


Crystal structure of the aminoglycosyl antibiotic puromycin dihydrochloride pentahydrate. Models for the terminal 3'-aminoacyladenosine moieties of transfer RNA's and protein-nucleic acid interactions.


Expression of the mitochondrial genome in HeLa cells. XIV. The relative positions of the 4 S RNA genes and of the ribosomal RNA genes in mitochondrial DNA.


The calorie, the joule.

The calorie, the joule.


Studies on the competitive absorption of neutral L-amino acids from the avian small intestine.


Dietary protein and utilization of carotene or retinyl acetate in rats.


Cerebrospinal fluid pressure, growth, and hematology in relation to retinal status of the rat in acute vitamin A deficiency.


Obligatory urinary and fecal nitrogen losses in young Chinese men.


Protein requirements of man: variations in obligatory urinary and fecal nitrogen losses in young men.


Dietary calcium and fluoride interactions in swine: effects on physical and chemical bone characteristics, calcium binding protein and histology of adults.


Dietary calcium and fluoride interactions in swine: in utero and neonatal effects.


Effects of high tryptophan doses and two experimental rations on the excretion of urinary tryptophan metabolites in cattle.


Relationship of biotin and ascorbic acid in the turkey poult.


Fetal growth and placental permeability in rabbits fed cholesterol.


Effects of excess calcium on a fluoride-magnesium interrelationship in chicks.


Effect of purification and cellulose treatment on the hypocholesterolemic activity of crude konjac mannan.


National commitment for mental health.

National commitment for mental health.


All things to all people.

All things to all people.


Focus on service.

Focus on service.


The community as a mental health system.


Studies on blood platelet release reaction. I. Acid phosphatase availability.


Two mechanisms of erythrocyte destruction in penicillin-induced hemolytic anemia.


Bile composition at and after surgery in normal persons and patients with gallstones. Influence of cholecystectomy.


Rejuvenation and freezing of outdated stored human red cells.


Staphylococcal scalded-skin syndrome in an adult.


Opinions for 1973.

Opinions for 1973.


Hypertension as a localizing sign of mass lesions of brainstem.


Cyanate effect on sickling.

Cyanate effect on sickling.


Effect of plasma expanders in toxemia of pregnancy.


Technic of lumbar puncture.

Technic of lumbar puncture.


Heart valve replacement using homografts.


Jamie.

Jamie.


Myocardial infarction.

Myocardial infarction.


Clomipramine intravenous drip: treatment of obsessional and phobic anxiety states.


What is your score? A check list for hospitals for the mentally handicapped.


Peopleprocessing.

Peopleprocessing.


Health teaching--a team approach. The role and preparation of the teacher.


A study of coronary heart disease.

A study of coronary heart disease.


Selection or diagnosis? The use of psychometric tests with candidates for student nurse training.


Problems associated with microbiological patents.


Biosynthesis of rifamycins.

Biosynthesis of rifamycins.


Biosynthesis of the lincomycins.

Biosynthesis of the lincomycins.


The radiographic findings in renal tubular acidosis: analysis of 21 cases.


Urography in renal failure: acid-base balance.


Pathways of biosynthesis of peptide moieties of streptothricin antibiotics.


The fuzzy fluid level sign: reappraisal of its cause and diagnostic value.


Biosynthetic and semisynthetic rifamycins.


The upside-down spleen.

The upside-down spleen.


Time of optimal gallbladder opacification with telepaque (lopanoic acid).


The pointed tubular bone, its significance and pathogenesis.


Central chondrosarcoma of the appendicular skeleton.


Dislocation of the proximal fibula.

Dislocation of the proximal fibula.


Clavicular cortical thickness as risk index of vertebral compression fractures.


Dissecting aneurysm of the aorta: aortographic features affecting prognosis.


Nonfundic gastric varices.

Nonfundic gastric varices.


Venous drainage to the inferior sagittal sinus.


The histologic effects of some iodine-containing contrast media on the rat peritoneal cavity.


Clinical experience with circular angiotomography.


Radionuclide cisternography in subdural hematomas.


Determination of bone mineral content using the scintillation camera.


Lung perfusion pattern associated with widespread occlusion of the pulmonary vessels and lymphatics.


Splenic accumulation of  87m Sr in a patient with Hodgkin's disease.


Thoracic duct leakage in neonatal chylothorax visualized by  198 Au lymphangiography.


Optimizing window size for fluoroscopic videodensitometry.


Genetic problems related to radiology practices.


Accumulation of ionic  67 Ga in empyema of the gallbladder.


Modified umbilical artery catheter for power-injection aortography.


Exploration of the tracheobronchial tree with the fiberoptic bronchoscope.


A practical film mount for roll film.

A practical film mount for roll film.


The Cronkhite-Canada syndrome.

The Cronkhite-Canada syndrome.


An inflatable oral-cavity retractor.

An inflatable oral-cavity retractor.


Epidemiological studies on the 1967-68 foot and mouth epidemic: attack rates and cattle density.


Functional recovery following incision of spinal meninges in dogs.


The experimental transfer of adult Fasciola hepatica between various mammalian hosts.


Galactose elimination as a liver function test in goats.


Metabolism of ovine IgG-I and IgG2.

Metabolism of ovine IgG-I and IgG2.


The effect of vasopressin on urinary excretion of Bos taurus and Bos indicus-crossbred cows.


Evidence of an acquired resistance in calves to a single experimental infection with Fasciola hepatica.


Bacteriological and serological diagnosis of salmonellosis of fowls.


Comparative studies on digestion and fermentation rate in the fore-stomach of the one-humped camel and the Zebu steer.


Scanning electron microscopy of erythrocytes of dog, cat, cow, horse, sheep and goat.


Stimulation of lachrymation and salivation in the adult fowl (Gallus domesticus).


Treatment of drug-resistant coccidia with acriflavine.


A method of recording electromyographs from a limb muscle during locomotion.


Binding sites for cationic proteins on staphylococci.


Breakdown: a needed fourth step in the conceptual armamentarium of modern medicine.


The sick role--illness and pregnancy.

The sick role--illness and pregnancy.


Organization and psychological problems in developing community mental health services: a case study.


The expanding definition of disease and health in community medicine.


Smoking, psychological status and stress.


Emergency intravenous cholangiography in acute abdominal pain. A review.


Toward a general theory of psychosocial deviance: the case of aggressive behavior.


Tumor immunology and the lymphatic system.


The significance and treatment of the occult obstructive uropathy complicating Crohn's disease.


The interaction of toxic amounts of lead and zinc fed to young growing horses.


Stimulation of active immunity to Langat virus in the presence of maternal antibody.


The work of the royal college.

The work of the royal college.


Intravenous prostaglandin F2  for therapeutic abortion: the efficacy and tolerance of three dosage schedules. To determine the most optimal procedure for use of prostaglandins (PGs) clinically for abortion, the abortifacient efficacy and complications of 3 types of intravenous PGF2 alpha schedules were compared over 18 hours.  17 healthy women from 7-20 weeks gestation were infused with PGF2 alpha for therapeutic abortion.  The subjects were divided into 3 groups: 1 receiving a constant infusion beginning at 25 mcgm/minute increasing to 200 mcgm up to the maximum FDA dose; the second receiving progressive doses at specified times until the patient developed 350 Montevideo units (MU) of uterine activity; and the third receiving 25 mcgm/minute for 1/2 hour followed by maintenance at 50 mcgm/minute until abortion.  All patients aborted with the low-dosage schedule and there were fewer complications.  No difference in uterine contractility was seen among subjects receiving the 3 dosage schedules or between those patients aborting and those who failed to abort.


Clinical applications of ultrasound in obstetrics and gynecology.


Sudden and rapid virilization during pregnancy.


Uterine vascular bed: effects of acute hypoxia.


Plasma volume, electrolyte, and coagulation factor changes following intra-amniotic hypertonic saline infusion. To determine the relationship of coagulapathy to saline infusions for abortion, plasma volume, electrolyte, and coagulation factors were studied in 6 patients of a gestational average of 18 weeks undergoing intraamniotic hypertonic saline  infusion for therapeutic abortion.  Blood samples were taken before the operation and afterwards at 3-hour intervals for 30 hours.  Mean plasma volume increased by 8.9% of the base-line values by 15 hours.  The direct correlation found between fluid intake, weight, and plasma volume indicates that unlimited fluid intake may be allowed following saline infusion.  Serum electrolytes showed no significant change.  Urine sodium and chloride increased at 3 hours, reaching a peak of 60 meg at 27 hours, and returning to base-line values at 36 hours.  Urine potassium decreased at 3 hours and remained slightly below base-line values for the remainder of the test period.  Disperse variations in the coagulation factor studies might suggest mild diffuse intravascular coagulation, but further research is required.


Paracervical block in obstetrics.

Paracervical block in obstetrics.


Quantitation of transport of sodium across the amniochorion.


Exploratory celiotomy for surgical staging of cervical cancer.


Suprapubic cystotomy by trocar catheter: a preliminary report.


Evaluation of the colpocleisis operation: a report of fifty-eight cases.


Maternal-fetal electrocardiogram conduction with intrapartum fetal death.


A simplified method for estimation of estriol in pregnancy plasma.


Case report of achondroplasia.

Case report of achondroplasia.


Thrombosis of the digital vessels secondary to oral contraceptives. A 27-year-old woman who used oral contraceptives for 2 years and had 2 incidents of blurred vision followed by painful "blood-red" fingers is described.  Contraceptive treatment was stopped.  Most fingers of both hands were characterized by bluish, cyanotic, apparent pregangrenous discoloration.  All laboratory tests were within normal range except; latex agglutination (weakly reactive), LE preparation (weakly positive twice, normal once), globulin immunoeletrophoresis (slightly elevated IgM), and blood volume determination (500 ml  deficit of whole blood).  500 ml daily of low molecular weight dextran for 4 days was the only treatment.  Gradually over 2 weeks cyanosis and pain ebbed.  The hypothesis that this thromboembolic trouble is linked to the pill is circumstantial, but episodes of blurred vision are symptomatic of retinal vessel thrombosis.  Erythema or pain in finger tips is the first sign of difficulty and should produce cessation of the pill.


Amniotic fluid and maternal and cord serum levels of gentamicin after intra-amniotic instillation in patients with premature rupture of the membranes.


Alcohols of human cervical mucus.

Alcohols of human cervical mucus.


Allergic reactions to saccharin.

Allergic reactions to saccharin.


Leiomyoma of the ovary.

Leiomyoma of the ovary.


Diagnosis of mycotic vulvovaginitis.

Diagnosis of mycotic vulvovaginitis.


Anesthesia and hepatic necrosis.

Anesthesia and hepatic necrosis.


Intra-amniotic injection of Evans blue dye.


Changes in the in vitro metabolism of estradiol by human endometrium during the menstrual cycle.


Latent ectopic pulmonary choriocarcinoma associated with renal cell carcinoma.


Colposcopy and cryosurgery in cervical intraepithelial neoplasia.


Rhabdomyosarcoma of the corpus uteri. Report of two cases with review of the literature.


Management of uterine perforations suffered at elective abortion.


First ovulation after childbirth: the effect of breast-feeding.


Endotoxin shock in the dog. Alterations in hemodynamic and hematologic parameters during bolus and infusion studies.


Tubal pregnancy following application of tantalum clips at culdoscopy for sterilization. In 1971, a 30-year-old woman underwent a culdoscopic tubal ligation with the application of tantalum clips.  She was healthy on first examination and 3 weeks after the operation.  Procedure included local anesthesia, meperidine and diazepam analgesia, Weck-Gutierrez clamp for delivering the fallopian tubes, and Weck Hemo-clips applied to the mid ampullae.  The patient failed to appear for hysterosalpingogram after her first menses, but returned for abdominal complaint 7 months later.  Eleven months after the operation she reported with 5 weeks of amenorrhea, followed 3 days later by cramps and bleeding.  Pelvic exam, culdocentesis, and laparoscopy showed a mass in the left fimbria.  Pathology revealed a slit lumen on the left, and flat epithelium, attenuated muscle layer bilaterally.  The failure to obtain hysterosalpingography and to reveal incomplete occlusion of the tube in this case suggest a need for meticulous follow-up care.  The role of epithelium and of muscularis in pregnancy is unclear.


Subcellular localization of human placental acid phosphatases.


Child development after pregnancies complicated by low urinary estriol excretion and pre-eclampsia.


Familial occurrence of congenital absence of the vagina.


Evidence of plasma prolactin levels in patients with breast cancer.


Release of prostaglandin F 2   following injection of hypertonic saline for therapeutc abortion: a preliminary study. To test the theory of the mechanism by which hypertonic sodium choride solution induces abortion, i.e., that prostaglandins (PGs) are released from damaged decidual cells, the concentration of PGF2alpha was measured in amniotic fluid before and after extraamniotic injection of 20% sodium chloride in 3 women in the 17-27 gestation week.  In all 3 patients amniotic fluid concentration of PGF2alpha increased 24 hours after the injection, i.e., before uterine contractions were fully effective, and thereafter showed a further increase (e.g., patient 1, 0 before and 1.4 24 hours after injection; Patient 2, .9 before and 5.3 after; and Patient 3, .2 before and 3.4 ng/ml after 24 hours).  Injection-abortion intervals were 34, 32, and 54 hours, respectively.  In the 54-hour abortion patient, PG level was 7.2 ng/ml 20 hours before abortion.  The results indicate that PGF2alpha is released into the amniotic fluid after extraamniotic injection of hypertonic saline.  Whether the release of PG was the cause or consequence of increased uterine activity is unknown.


Hepatic rupture in pregnancy.

Hepatic rupture in pregnancy.


Extragenital adenocarcinoma metastatic to the cervix uteri.


Cytologic smears and invasive carcinoma.


Sterilization procedures.

Sterilization procedures.


Divergence of opinion on placental damage due to hypertonic saline-induced abortion. The issue of the mode of efficacy of hypertonic saline-induced abort ion during midpregnancy is discussed.  Some investigators claim the procedure results in severe damage to the placenta and a consequent reduction in progesterone synthesis, while others claim that these effects are minimal, if present.  The confusion can be eliminated, it is claimed, if the following experimental saline and the volume infused, 2) the thickness and size of the placenta, 3) the total volume of amniotic fluid, 4) the amount of amniotic fluid removed before  saline infusion, and 5) the duration of exposure.  It is important to properly select the experimental paramters for hypertonic saline abortion in order to minimize its inherent danger.


Intraepithelial carcinoma of the vulva.

Intraepithelial carcinoma of the vulva.


Intestinal obstruction and endometriosis.


Nuclear concentration of estradiol in superfused slices of human endometrium.


Spontaneous pneumothorax.

Spontaneous pneumothorax.


Treatment of comminuted fractures of the distal radius with self-contained skeletal traction.


Resection of pulmonary secondary tumors.


Simpler surgery in the treatment of postgastrectomy malnutrition.


Experience with parathyroid surgery in a community hospital.


Traumatic injuries of the portal vein.

Traumatic injuries of the portal vein.


Pitfalls in the surgery of aldosterone-producing tumors.


Internal arteriovenous fistula for hemodialysis.


Venous stasis on the operating table.

Venous stasis on the operating table.


Variations in total serum bilirubin and alkaline phosphatase in the normal postoperative cholecystectomy course.


The precise management of heparin therapy.


Defective collagen synthesis in inguinal herniation.


Studies on solvent extraction techniques for activation analysis of serum.


Exploratory laparotomy for staging in Hodgkin's disease. Diagnostic yield versus operative morbidity.


Electroreduction and polarographic determination of 2-phenylindan-1,3-dione in serum.


A new assay for cholinesterase potentiometric determinations in flow streams.


The internal standard addition method in x-ray fluorescence analysis of biological materials.


A scanning electron microscopic study of the ependymal surface of the third ventricle of the rabbit, rat, mouse and human brain.


Anatomical observations on the arterial supply to the lumbosacral spinal cord of the cat.


The effects of hyperthyroidism on the fine structure of the zona fasciculata of the rat adrenal cortex.


Ultrastructure of the rat testis after vasectomy.


A comparison of a systematic sampling method with complete random sampling for estimating total numbers of nerve fibers.


Further evidence for the vitality of chondrocytes in the mandibular condyle as revealed by  35 S-sulfate autoradiography.


Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat.


Electron microscopic studies on fate of erythroblast ribosomes.


Aortic and coronary atherosclerosis in a Finnish autopsy series of violent deaths.


Induction of increased airway obstruction by exercise or voluntary hyperventilation in asthmatic children.


Detection of delayed hypersensitivity in ragweed pollinosis by an in vitro method.


Treatment of hereditary angioedema with frozen plasma.


Buckwheat sensitivity in children.

Buckwheat sensitivity in children.


The anatomy of the post-nasal space: its significance in local malignant invasion.


Spontaneous rupture of the oesophagus.

Spontaneous rupture of the oesophagus.


Renal arteriovenous fistula resulting in death from cardiac failure: report of a case.


Melorheostosis.

Melorheostosis.


Branch involvement at aortography in dissecting aneurysm, with particular reference to the lower intercostal and renal arteries.


Paget's disease of bone (osteitis deformans) amongst the West Malaysians.


The folded breast prosthesis: a new clinical and radiological entity.


Fundamental principles in organ sizing.

Fundamental principles in organ sizing.


Relative hazards to radiation workers in various classes of diagnostic x-ray procedures, with special reference to ward and theatre radiography.


His bundle electrogram in children. Statistical correlation of the atrioventricular conduction times in children with their age and heart rate.


Systematization and clinical study of dextroversion, mirror-image dextrocardia, and laevoversion.


Effect of phentolamine on atrioventricular conduction in man assessed by recording His bundle potential.


Wenckebach phenomenon within the atria.

Wenckebach phenomenon within the atria.


Second-degree Wenckebach type AV block due to block within the atrium.


Acute major pulmonary embolism as a cause of exaggerated respiratory blood pressure variation and pulsus paradoxus.


Diagnostic value of vectorcardiogram in strictly posterior infarction.


Haemodynamic and sound events preceding first heart sound in mitral stenosis.


P wave of electrocardiogram in early ischaemic heart disease.


Signs of pericardial constriction in rupture of ventricular septum complicating myocardial infarction.


His-Tawara bundle in complete AV block complicating double outlet right ventricle with intact interventricular septum.


Coronary artery disease in a young man with normal serum lipids.


Transvenous pacing in presence of anomalous venous return to heart.


Organic anion transport in the maturing dog choroid plexus.


Scanning and electron microscopical investigations of the surface structures of the lateral ventricles in the cat.


The mechanism of selective reinnervation of fish eye muscles. 3. Functional, electrophysiological and anatomical analysis of recovery from section of 3rd and IVth nerves.


The mechanism of selective reinnervation of fish eye muscles. IV. Identification of repressed synapses.


Uptake of ( 3 H)thymidine by corpus callosum cells in rats following a stab wound of the brain.


Axonal endings in the cat medial superior olive: coated vesicles and intercellular substance.


Enhanced alternation learning in hippocampectomized rats by means of added light cues.


Quantitative relationships between nerve and satellite cells in spinal ganglia. An electron microscopical study. I. Mammals.


Generation times of the matrix cells during embryonic brain development: an autoradiographic study in rats.


The developing neostriatum of the rabbit: correlation of fluorescence histochemistry, electron microscopy, endogenous dopamine levels, and ( 3 H)dopamine uptake.


An immunochemical comparison of brain microtubule protein (tubulin) with tubulin and actomyosin-like protein from the adrenal medulla.


Differential effects of anesthetics on neutral proteinase activity of rat brain regions according to time of day.


Nuclear magnetic resonance studies suggestive of a lipid population tightly bound to myelin structural proteins.


Uptake of androgens by the brain of the neonatal female rat.


Cycloheximide alters the neural and behavioral responses of mice to electroconvulsive shock.


A repeatable micro-iontophoretic technique for inorganic cations.


Selective accumulation of ( 125 I) labelled nerve growth factor in sympathetic ganglia.


Reticular ascending activation of frontal cortical neurons in rabbits, with special reference to the regulation of deglutition.


Activity of vestibulospinal neurons during locomotion.


Activity of rubrospinal neurons during locomotion.


Responses of previously reinfected rubella vaccinees to challenge with Brown strain rubella virus. The responses of seven hpv-77 rubella vaccinees to initial challenge with "wild" rubella virus have been compared with their responses to rechallenge with Brown strain rubella virus and to the responses of five "natural" immunes to initial Brown strain challenge. Previous exposure to "wild" rubella virus 220 days post vaccine-induced immunity had resulted in six of the seven vaccinees experiencing asymptomatic reinfection. On "rechallenge" none of the previously "reinfected vaccine immunes" demonstrated clinical, virologic or serologic evidence of reinfection. These data are consistent with the conclusion that persons with vaccine-induced immunity may be assured of more prolonged and solid immunity to rubella without having to suffer the clinical disease if they are reinfected with nonattenuated rubella virus. Rigidly controlled experiments, designed to study the practicality and safety of immunization with live rubella vaccine(s), followed by deliberate challenge of vaccinees with "wild" or low tissue culture passage rubella virus, seem warranted. In addition, these data indicate that it is imperative that a distinction should be made between "vaccine immunes" and previously "reinfected vaccine immunes" in any evaluation of long term rubella vaccine(s) efficacy and vaccine-induced antibody decay.


Rifampin in the treatment of pulmonary tuberculosis. Rifampin is a newer semi-synthetic derivative of rifamycin. Its advantages over other derivatives are good oral absorption, high blood levels, and slower excretion rate. Rifampin has been studied in 68 patients and results can be summarized as follows:* There has been no evidence of significant toxicity.* In a randomized study of active tuberculosis patients who had not received prior chemotherapy, isoniazid-rifampin and isoniazid-aminosalicylic acid regiments were equally effective.* In retreatment patients with active, positive tuberculosis, the regimen of isoniazid, rifampin, and ethambutol proved to be very effective, especially when the two latter drugs had not been used previously.* In patients with pulmonary infections caused by atypical acid-fast bacilli, results varied with the organism isolated and the extent of disease. Rifampin is a potent, relatively non-toxic drug especially useful in the retreatment of pulmonary tuberculosis in patients who have never received this drug previously. There is little justification for its use in initial therapy except in rare cases.


Metronidazole versus anaerobes. In vitro data and initial clinical observations. Metronidazole, a systemic trichomonicide which has been used extensively since 1960, has recently been shown to be active against various anaerobic bacteria in vitro and in experimental infections. In the present study, metronidazole showed significant activity against virtually all of 54 strains of anaerobic and microaerophilic bacteria tested, including Bacteroides fragilis. Since this organism is the anaerobe most commonly isolated from human infections and has demonstrated significant resistance to many antimicrobial agents, metronidazole may prove to be very useful. Our initial clinical evaluation of metronidazole in human anaerobic infections is presented. Because of metronidazole's in vitro activity, its low incidence of toxic reactions, and this initial favorable clinical trial, the drug deserves further evaluation in the management of anaerobic infections.


Epidemiologic treatment in venereal disease. A method to aid in VD control. Epidemiologic therapy refers to the treatment of infectious syphilis or gonorrhea contacts without proof of laboratory diagnosis. This method of treatment is considered essential by public health authorities in the management of venereal disease, but has long been neglected in the private sector of medicine. The majority of venereal disease patients are treated by private practitioners, but apathetic attitudes, insufficient training, lack of case reporting, differing and often inadequate treatment schedules, poor follow-up and ignorance about or reluctance to use epi-treatment are all factors in our losing struggle against the current venereal disease epidemic.


Allergic rhinitis.

Allergic rhinitis. Taken from the weekly Pediatric Grand Rounds held at the University Hospital of San Diego County, University of California, San Diego, School of Medicine, November 9, 1971


Physician power.

Physician power.


Allergic rhinitis.

Allergic rhinitis.


Toxicity by interaction of tricyclic antidepressant and monoamine oxidase inhibitor.


Congenital absence of pectoral muscles.

Congenital absence of pectoral muscles.


Mycoplasmal pneumonia associated with abscess of the lung.


A new community health care center. The Our Lady of Guadalupe facility in Daly City.


Fascioliasis. Response to bithionol.

Fascioliasis. Response to bithionol.


Public health report. Hazardous waste disposal.


Selected item from the FDA drug bulletin. Use of drugs for unapproved indications: legal responsibility.


Vasoconstrictive primary pulmonary hypertension and pulmonary veno-occlusive disease.


Intermittent rate-related left anterior hemiblock.


Teleradiology: evolution through bias to reality.


Mysteries of sudden death and myocardial infarction.


Alterations in airway dynamics following inhalation of ultrasonic mist.


Persistent post-embolic pulmonary hypertension.


Pulmonary artery aneurysm associated with mitral valve disease: a grave prognostic sign.


Phase-3 and phase-4 intermittent left anterior hemiblock. Report of first case in the literature.


ST segment depression with near-maximal exercise: its modification by physical conditioning.


Prediction of pulmonary function loss due to pneumonectomy using  133 Xe-radiospirometry.


Quantitative study of parenchyma and small conductive airways in chronic nonspecific lung disease. Use of histologic stereology and bronchial casts.


Use of percutaneously inserted venous catheters in coronary care units.


Oxyhemoglobin affinity in bronchial asthma: chronic stable state, acute, and status asthmaticus.


Percutaneous needle biopsy of the lung with a new disposable needle.


Systolic time intervals, relation to atrial contraction and leg elevation in patients with transvenous pacemakers and fixed rate pacing.


Esophagopericardial fistula presenting as cardiac tamponade.


The apexcardiogram in patients with the syndrome of midsystolic click and late systolic murmur.


Asymptomatic right lower thoracic nodule.


Ventricular fusion beats simulating bilateral, bundle branch block.


Remission of symptoms in mitral stenosis due to complete heart block.


Pulmonary lesions in rheumatoid arthritis.


Isolated tricuspid bacterial endocarditis resulting in severe tricuspid insufficiency.


Solitary pulmonary nodule due to phycomycosis (mucormycosis).


Congenital superior vena cava aneurysm with complications caused by infectious mononucleosis.


Aortic valve replacement for candida endocarditis.


Diagnosis of a case of embryonal carcinoma by bronchial biopsy.


Bronchial carcinoid: a malignant tumor.

Bronchial carcinoid: a malignant tumor.