A serum-free medium for testing fermentation reactions in Neisseria gonorrhoeae. Gonococcal infections can no longer be considered exclusively urogenital but it is difficult in a busy routine laboratory to identify gonococci from non-genital sites, especially if other commensal neisseria are present. Unfortunately, conventional serum agar sugars sometimes give equivocal results. A fermentation medium is described for the identification of gonoccoci. On preliminary testing this medium gives rapid and reliable results and should prove to be much more helpful to the routine laboratory than conventional serum agar sugars. Its potential usefulness, as demonstrated by the results of our first 200 examinations, would seem to justify further study in the routine work of other laboratories.


Trimethoprim-sulphamethoxazole in urinary tract infection due to Streptococcus faecalis. In-vitro sensitivities were performed on 140 specimens of urine which grew Streptococcus faecalis of more than 100 000 organisms/ml between March 1970 and February 1971. Although the combination of trimethoprim and sulphamethoxazole definitely appeared to be more effective than sulphonamide alone and as effective as ampicillin, its use for more than two weeks in 14 cases of uncomplicated urinary tract infection due to Streptococcus faecalis led to development of resistance. As in these cases organisms were resistant to sulphonamide to start with, it is suggested that the combination should be used in prolonged treatment only where the organisms are sensitive to both the individual antibiotics. Ampicillin is still the drug of choice in urinary tract infection due to Streptococcus faecalis. The alternative appears to be rotational therapy with other potent antibiotics.


An evaluation of the Celloscope 401 electronic blood cell counter. For counting erythrocytes the instrument was precise, with a mean coefficient of variation of 1.21%. Erythrocyte counts showed close agreement with results obtained on a Coulter A electronic counter of proven accuracy. When the Celloscope 401 was modified by the manufacturers to eliminate electrical interference from other laboratory equipment, satisfactory precision and accuracy for white cell counting was obtained. Using cetrimide diluent the coefficient of variation was 1.6% but when using saponin/saline diluent the coefficient of variation was 3.5%. For leucocyte counting there was close agreement between duplicate tests performed on the Celloscope 401 and the Coulter S. The instrument was capable of satisfactory precision and accuracy in platelet counting, provided that the sedimentation method was used to obtain a platelet-rich plasma. The best results were obtained if a two-step dilution was carried out with a first dilution in 10% EDTA and a second in 2.5 mM cocaine in water. Using this method the precision study indicated a coefficient of variation of 3.11%. Close agreement was obtained between platelet counts on the Celloscope 401 when compared with the results obtained either by phase-contrast microscopy or using another electronic counter. Allowing for predilution and duplicate counts on each sample, the rate of throughput was approximately 32 samples per hour. Throughout the test period, the instrument remained electronically and mechanically stable.


Experimental pertussis infection in the vaccinated and unvaccinated marmoset: similarities to natural infection in the child.


Protein transport in mouse kidney utilizing tyrosinase as an ultrastructural tracer. The morphological basis of glomerular filtration and protein reabsorption in mouse kidney was examined by using mushroom tyrosinase subunits (mol wt 34,500), as an ultrastructural tracer. Almost immediately after injection tyrosinase reaction product was visualized in the glomerulus, and within the capillary lumen extending into the endothelial fenestrae. The entire basement membrane showed accumulations of tyrosinase in the subendothelial and subepithelial layers. The urinary space contained considerable amounts of reaction product, some of which was adsorbed to the cell coat of the podocytes. Reaction product could also be seen in the brush border region of the proximal tubule cells. By 30 min after injection, no tyrosinase reaction product was demonstrable in the glomerulus except for dense vesicles in mesangial cells. Most of the reaction product was localized in absorption droplets in the apical cytoplasm of proximal tubule cells. Occasionally, some tyrosinase reaction product was present within the basal infoldings of these cells. The behavior of tyrosinase in the mouse kidney is in accordance with that of other low molecular weight tracers. The pattern of localization within the basement membrane provides additional support for the presence of two filtration barriers in the glomerulus. The adherence of tyrosinase to the cell coat of the glomerular epithelial cells suggests that this may be an additional mechanism whereby protein is removed from the glomerular filtrate. Tyrosinase subunits may prove to be a useful new tracer for the study of protein transport.


Picrotoxin-induced twitch potentiation and sarcotubular conductance changes.


Cell-mediated immune response in vitro. 3. The requirement for macrophages in cytotoxic reactions against cell-bound and subcellular alloantigens. All efficient cell separation procedure and specific anti-macrophage serum were used to investigate the requirement of macrophages in the in vitro allograft response of mouse lymphoid cells. The efficiency of the macrophage-depletion procedure used and the undiminished capacity of the purified lymphocytes to respond were verified by also testing the antibody responses to sheep red cells (SRC) and dinitrophenylated polymeric flagellin (DNP POL) as well as the proliferative response to allogeneic cells. It was found that the generation of cytotoxic lymphocytes were diminished after macrophage depletion by surface adherence. The combination of anti-macrophage serum and column purification resulted in the total abolition of cytotoxic activity. The cell-mediated immune response was restored completely by addition of peritoneal macrophages, with as few as 1 macrophage to 600 lymphocytes permitting a significant restoration. Macrophages were not involved in the cytotoxic effector phase, but were essential in immune induction. A subcellular H-2 alloantigen preparation was only immunogenic in the presence of macrophages, indicating that a mere reduction in the size of the antigen from cell-bound alloantigens to membrane fragments was not the sole function of macrophages. The results suggest that macrophages collaborate with T cells in the initiation of an allograft response in vitro.


Immune thrombocytopenia due to a drug metabolite.


Production of HL-A-specific antibodies in monkeys by immunization with soluble HL-A-antigens.


Isolation of the immunosuppressive fraction from horse antiserum to mouse thymus.


Responses of monkey optic tract fibers to monochromatic lights.


Maintained activity of monkey optic tract fibers and lateral geniculate nucleus cells.


Effects of chloramphenicol on heme synthesis.


Effect of serum vitamin B 12  binding on intrinsic factor antibody detection in pernicious anaemia.


Urinary iron excretion in nephrotic syndrome.


Bone marrow return and division of circulating acute lymphoblastic leukaemia cells.


Metabolic activity of polymorphonuclear leukocytes in sickle cell anemia.


Hemolytic anemia and pancytopenia in glutathione reductase deficiency: further experience with riboflavin.


The effect of certain hormones on platelet aggregation in vitro.


A case of haemoglobin J Sardegna- -thalassaemia double heterozygosis.


Urological considerations in space medicine.


Ash content of bones in the pigtail monkey, Macaca nemestrina.


Congenital anterior bowing of the tibia. The significance of the different types in relation to pseudarthrosis.


A novel closed circular duplex DNA in bleached mutant and green strains of Euglena gracilis.


A low molecular weight antiplasmin of human blood platelets.


On the isolation of materials with Rh antigenic properties from the human erythrocyte membrane.


Subacute sclerosing panencephalitis: a review.


Selective inhibition of RNA polymerase activity in rat liver nuclei by 4-(dimethylamino) azobenzene, and effect of nitrofurans on liver RNA metabolism associated with prevention of carcinogenesis.


Change in acid phosphatase during azo-dye carcinogenesis.


Detection of carbamate as a product of the carbamate kinase-catalyzed reaction by stopped flow spectrophotometry.


Recommendations for safer oral radiology.


The effect of a corticosteroid-antibiotic compound on the dental pulp. (A clinical and histopathological study).


Isolation in crystalline form and properties of six horse erythrocyte carbonic anhydrases.


Orthodontics and the general practitioner.


The retained impaction: a surgical prosthetic problem. Case report.


Autogenous transplants with and without endodontic treatment.


Synthetic antibacterials. 4. Nitrofurylvinylpyrido(2,3-d)pyrimidine derivatives.


Synthesis and biological activity of selected 2,6-disubstituted-(2-deoxy- -and- -D-erythro-pentofuranosyl)purines.


Intracoronary nitroglycerin, pentaerythritol trinitrate and dipyridamole on intramyocardial oxygen tension.


Fatal hyperalimentation syndrome.

Fatal hyperalimentation syndrome.


In vitro phagocytosis of fungal spores by rabbit lung macrophages.


Antibody in cerebrospinal fluid in non-meningitic coccidioidomycosis.


Ultrastructure of the onion bulb-like lamellated structure observed in the sural nerve in a case of von Recklinghausen's disease.


Optical rotatory dispersion and circular dichroic spectra of G-actin.


Absorption bands of multiple b and c cytochromes in bacteria detected by numerical analysis of absorption spectra.


Dopamine, extrapyramidal system, and psychomotor function.


Temperature and competitive anion-binding studies of carbonic anhydrase.


Autodegradation of RNA of plant cell ribosomes.


On a non-chlorophyllic magnesium fraction bound to plastidial lamellar proteins from Zea mays L.


Adenylate cyclase in the rat pancreas properties and stimulation by hormones.


The lytic behavior of pure phospholipase A 2  and C towards osmotically swollen erythrocytes and resealed ghosts.


Tracheopathia osteoplastica with pulmonary thromboembolic disease.


Schistosoma mansoni infection in rhesus monkeys: comparison of the course of heavy and light infections. The course of Schistosoma mansoni infection in rhesus monkeys exposed to 100 or 600 cercariae was compared. During the first 12 weeks, the numbers of eggs per worm pair passed in the faeces and retained in the tissues were similar in the two groups. Between weeks 12 and 27, two-thirds of the worms died in monkeys exposed to 600 cercariae, many surviving worms shifted from colonic to small intestinal venules, and the number of eggs per worm pair passed in the faeces decreased. None of these changes occurred in monkeys exposed to 100 cercariae and in these animals the number of eggs passed in the faeces consistently increased after the twelfth week. The findings indicate that study of a single level of infection is not adequate to define the host response, and that the relation between worm burden and the number of eggs in the faeces is considerably influenced by host response.Monkeys were also studied 6 and 7 weeks after exposure to 600 cercariae. After the seventh week of infection, inflammatory infiltrates in the colon and portal tracts became much less marked, and the granulomas surrounding mature eggs decreased in size.


Comparison of geographical strains of Schistosoma mansoni in the rhesus monkey. Rhesus monkeys were infected with strains of Schistosoma mansoni from Puerto Rico, St Lucia, Brazil, and Tanzania. Monkeys were killed 11-14 weeks after exposure to 600-650 cercariae. Some differences in the behaviour of different strains were noted, but the similarities between the strains were more remarkable. The only strain difference observed in both mice and monkeys was a prolonged prepatent period in animals infected with the Mwanza strain. The results of experimental infections are believed to be of little value in predicting possible differences in the pathogenicity of schistosome strains for man.


The assay of the molluscicide niclosamide using the ciliate protozoan Spirostomum ambiguum.


Some supplementary observations on the blood incubation infectivity test.


Serum lipoprotein levels in patients with cancer.


A trial of Ro 4-2137 in the treatment of hypertension.


Short term effectiveness and hemodynamic actions of guanadrel, a new sympatholytic drug.


Clinical study of orexigenic action of a new antiserotonin agent, BC-105, in patients with pulmonary tuberculosis.


Cephapirin dosage in childhood.

Cephapirin dosage in childhood.


Evaluation of piperacetazine (Quide) injection in acute schizophrenics.


Clinical trial of amoxapine (CL 67,772) with depressed patients.


Acupuncture "anesthesia"--a new theory and clinical study.


Clinical and EEG effects of GB-94, a "tetracyclic" antidepressant (EEG model in discovery of a new psychotropic drug).


Functional significance of the fibrous laminae in the ventrobasal complex of the thalamus of slow loris.


Depressive behavior in young monkeys subjected to vertical chamber confinement.


Ossification of the stapedius tendon.

Ossification of the stapedius tendon.


Carbonic anhydrase activity in rat neurohypophysis following osmotic stress.


Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease.


Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.


Cotinine N-oxide, a new metabolite of nicotine.


Experimental burn wound sepsis: variations in response to topical agents.


Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. Potent nonsteroidal antiinflammatory agents.


An experimental study of cervical spine and cord injuries.


Mechanics of cardiothoracic injury in primates.


Suppression of parathyroid gland activity by magnesium. Morphometric ultrastructural study.


Genetic disorders: prevention, treatment, and rehabilitation. Report of a WHO Scientific Group.


The Swedish drug monitoring system.

The Swedish drug monitoring system.


International drug monitoring: the role of national centres. Report of a WHO meeting.


The United Kingdom drug monitoring system.


The planning of a national drug monitoring system.


Thyroid function in the premature and the full term newborn.


Of monkeys and men.

Of monkeys and men.


Immunological procedures of relevance to allergists.


Staphylococcal delta hemolysin: purification and characterization.


Dissociation of human hemoglobin by different organomercurials.


Kinetic studies of a doubly bound red cell antigen-antibody system. The Polybrene method for detection of red cell antibodies which utilizes continuous flow equipment was modified so that kinetic studies could be performed on red cell antibodies doubly bound between adjacent red cells. In the anti-Rh(o)-Rh(o) erythrocyte system, deaggregation by temperature was studied over an antibody concentration range of from approximately 1 to 500 antibody molecules per erythrocyte, a residence time range of approximately eightfold, and a temperature range of from 10 to 55 degrees C. The rate of dissociation of antigen-antibody complex, as determined from deaggregation of antibody-dependent red cell aggregates, was found to be of apparent zero order. The apparent activation energy for the antigen-antibody reaction under the experimental conditions was determined and found to be higher than would be expected for singly bound antigen-antibody systems. Possible explanations are considered for these findings in terms of an antigen-antibody bond-breaking model.


A family of congenital atransferrinemia.


Hemoglobin Lepore Washington in two Jamaican families: interaction with beta chain variants.


Size dependence of ghosts from stored erythrocytes on calcium and adenosine triphosphate.


Management of recurrent malignant effusions.


Further thoughts on patient incentives.

Further thoughts on patient incentives.


Local and humoral chlamydial antibodies in trachoma patients of different age groups.


Wilhelm Konrad Röntgen (1845-1923).

Wilhelm Konrad Röntgen (1845-1923).


Selective detection of chlorinated insecticides in the presence of polychlorinated biphenyls.


Transplantation and cancer.

Transplantation and cancer.


Biopsy: definitive diagnosis of oral cancer.


Interaction of poly-L-lysine with chromatin. Inhibition of in situ priming for Escherichia coli DNA polymerase. The priming capacity of chromatin of fixed nuclei and chromosomes for exogenous DNA polymerase can be evaluated radioautographically by the incorporation of labeled nucleotides. It had previously been reported that acid fixation or acid treatment of alcohol-fixed tissues led to increased priming when calf thymus DNA polymerases, specific for single-stranded DNA, were used. We employed Escherichia coli DNA polymerase and sequential treatments of the fixed tissue with acid and poly-L-lysine in order to elucidate the mechanism through which the acid effect is produced. Acid treatment enhanced chromatin priming for the E coli DNA polymerase, and saturation of the chromatin with poly-L-lysine strongly inhibited the reaction. This inhibition was reversible through subsequent treatment with acid. Wide differences in priming were observed between cell types of alcohol-fixed chicken blood smears: thrombocyte and lymphocyte nuclei exhibited strong priming ability whereas erythrocyte nuclei failed to support any detectable priming. We conclude that the acid effect is readily interpretable in terms of acid-mediated changes in the association between DNA and protein in the chromatin complex.


Growth studies on the lactic streptococci. I. A laboratory apparatus suitable for fermentation studies using skim-milk medium.


Growth studies on the lactic streptococci. II. The effect of agitation on the growth characteristics of Streptococcus lactis ML 8  in batch culture.


Growth studies on the lactic streptococci. 3. Observations on continuous growth behaviour in reconstituted skim-milk.


Oral exfoliative cytology: an adjunct to biopsy.


On a new kind of rays.

On a new kind of rays.


Growth studies on the lactic streptococci. IV. Some observations on redox potential.


Simplified and sensitive detection of subtypes of Australia antigen (HB Ag) using a solid-phase radioimmune assay.


Questions and answers on breast cancer.

Questions and answers on breast cancer.


The effect of disodium cromoglycate in perennial rhinitis.


The effect of disodium cromoglycate on nasal polyp symptoms.


Cross-resistance in Pseudomonas aeruginosa resistant to phenylethanol.


Sterile topical dosage forms. I. Laboratory phase.


Oral and parenteral formulations of marijuana constituents.


A unified theory of bacterial motile behavior.


An early case of Hurler's syndrome (Hunter-Hurler-Pfaundler syndrome, mucopolysaccharidosis I, dysostosis multiplex): report of a case.


Ultraviolet inactivation and excision-repair in Bacillus subtilis. IV. Integration and repair of ultraviolet-inactivated transforming DNA.


Complete intravenous nutrition. Theoretical and experimental background.


Ultraviolet inactivation and excision-repair in Bacillus subtilis. 3. Sensitized photoinactivation of transforming DNA, and the effect of thymine dimers on differential marker inactivation and differential marker repair.


Listeriosis as a cause of fetal wastage.


Prophylaxis of neonatal hyperbilirubinemia with phenobarbital.


The present status of sodium cromoglycate.


The allergic child.

The allergic child.


Acute perforation of duodenal diverticulum with roentgenographic demonstration of localized retroperitoneal emphysema.


Detection of malabsorption of vitamin B12 due to gastric or intestinal dysfunction.


Abnormalities of the gastrointestinal transport of iron.


Radionuclide determination of gastrointestinal blood loss.


Analysis of steroids. XXI. A spectrophotometric method for the determination of 21-amino corticosteroids.


A total of 254 cases of angina pectoris treated with oxprenolol in hospital practice--a monitored release study.


Insulin and IgG complexes. An immunologic bypass for complement activation.


Inhibition of melanoma tyrosinase by fusaric acid.


Mapping of central monoamine neurons in the monkey.


Specific anti-antibodies.

Specific anti-antibodies.


Another failure of a commercial x-ray shutter system.


Absorption and retention of cobalt in man by whole-body counting.


A hybrid-computer model of the cochlear partition.


Ceramic root implantation in baboon.

Ceramic root implantation in baboon.


Radiologic seminar. CXVII. Bladder diverticula and herniations.


How toxic is hexachlorophene?

How toxic is hexachlorophene?


The morphology of Trypanosoma theileri in the blood of cattle, and the rediscovery of Theileria mutans in England.


Comparison of calcium and phosphorus excretion with bone density changes during restraint in immature Macaca nemestrina primates.


Effects of bedrest and centrifugation of humans on serum thyroid function tests.


Mode of action of primaquine: preferential inhibition of protein biosynthesis in Bacillus megaterium. The growth of a strain of Bacillus megaterium was prevented by a minimal inhibitory concentration of primaquine of 52 mug/ml or 2 x 10(-4)m. When exponentially growing cultures received the drug at 6 x 10(-4)m, the rate of growth was drastically reduced and no further growth occurred after 15 min of exposure. At this concentration, primaquine was bactericidal, causing a 50% reduction in the viable population after one doubling time of 45 min. Supplying primaquine to cultures 30 min after adding radioactive-labeled phenylalanine, thymidine, uracil, or diaminopimelic acid produced an immediate and complete inhibition of protein biosynthesis but no inhibition of deoxyribonucleic acid biosynthesis for at least 15 min, and caused the formation of ribonucleic acid and cell wall polymer to proceed linearly at rates similar to those established prior to the addition of drug. This pattern of inhibition of macromolecular biosyntheses suggests that the major in vivo action of primaquine in B. megaterium is to block protein synthesis.


Antimicrobial properties of natural phenols and related compounds: obtusastyrene and dihydro-obtusastyrene. Factors influencing the antimicrobial properties of obtusastyrene and dihydro-obtusastyrene were studied. Both of these compounds were soluble in acetone, alcohol, and olive oil. In water, they were soluble at concentrations of 34 and 53 mug/ml, respectively. The minimal inhibitory concentrations against gram-positive bacteria and yeast were below 100 mug/ml. The compounds were not effective against gram-negative bacteria at 200 mug/ml or lower concentrations. With initial populations of cells greater than 10(6)/ml, the concentrations of these compounds required to prevent growth were greater than with lower cell populations. Changing the pH of the growth medium did not decrease the effectiveness of these two compounds in the pH range of 3 through 8. Both obtusastyrene and dihydro-obtusastyrene were rapidly bactericidal to Staphylococcus aureus and Bacillus cereus at 25 mug/ml.


Effect of secondary metabolites on the organisms producing them: effect of nisin on Streptococcus lactis and enterotoxin B on Staphylococcus aureus. The effect of secondary metabolites added to cultures of the organisms producing them was investigated. Nisin was added to growing cultures of a nisin-producing strain of Streptococcus lactis (354/07) and enterotoxin B to strains of Staphylococcus aureus (S6 and 243) producing enterotoxin B. One quarter (12 mug/ml) of the amount of nisin formed by the culture of S. lactis inhibited lag-phase cells and lysed log-phase cells. The same amount of nisin added before inoculation or at a time when nisin synthesis had started (in late log phase), caused only transient delay in growth. Inhibition of growth of the two enterotoxin B-producing strains of S. aureus could not be demonstrated at any stage of their growth cycle with as much as 1 mg of enterotoxin B per ml of medium.


Cross-resistance of Pseudomonas to gentamicin and tobramycin. Clinical isolates of gentamicin-resistant organisms were found to be resistant to tobramycin, a new aminoglycoside antibiotic.


Heterotopic adipose tissue and smooth muscle in the optic disc: association with isolated colobomas.


The cerebral effects of hypotension produced by deep halothane anaesthesia.


Regulation of cardiac output after administration of isoproterenol and ouabain: interactions of systolic impedance and contractility.


The prevention of clumping of frozen-stored leukocyte populations by EDTA.


Glomerulonephritis in childhood.

Glomerulonephritis in childhood.


Effect of CO 2  and NH 3  on bioconvection: patterns in Tetrahymena cultures.


Cyclic replication of DNA and changes in mitochondrial morphology during the cell cycle of Euglena gracilis (Z).


The cervix uteri in Macaca mulatta, Macaca arctoides, and Macaca fascicularis--a comparative anatomic study with special reference to Macaca arctoides as a unique model for endometrial study.


Ecdysone induction of puffing in polytene chromosomes of Drosophila melanogaster. Effects of inhibitors of RNA synthesis.


Are there two liver azoreductases?

Are there two liver azoreductases?


Post-traumatic epilepsy.

Post-traumatic epilepsy.


Intrajejunal volatile fatty acids in the stagnant loop syndrome. In the stagnant loop syndrome an abnormal anaerobic flora colonizes the small bowel. Anaerobic organisms are characterized by fermentation reactions leading to the production of volatile fatty acids. This paper describes the measurement of intrajejunal volatile fatty acid concentrations in 11 patients with the stagnant loop syndrome. Nine normal persons and 18 patients with gastrointestinal disease without intestinal stasis acted as controls. Acetate and propionate concentrations were greatly increased in the patients with the stagnant loop syndrome and returned to normal in those patients treated with antibiotics. The measurement of intrajejunal volatile fatty acid concentrations as an index of overgrowth of anaerobic organisms is discussed.


Coeliac disease, vasculitis, and cryoglobulinaemia. Four patients are described with the association of adult coeliac disease, vasculitis, and cryoglobulinaemia. In each patient the cryoglobulinaemia was of the mixed type consisting of more than one immunoglobulin class. It is suggested that the mixed cryoglobulins represent circulating immune complexes and that their deposition in small vessels causes the vasculitis. This is supported by immunofluorescent studies of skin biopsies from one of these patients. The significance of these findings in the four adult coeliac patients is discussed.


Standardization of immunoglobulin reagents.


Technical aspects of the detection and characterization of immunoglobulin dyscrasis.


Characterization of a conjugated anti-serum for the detection of Treponema pallidum by the direct fluorescent antibody technique.


From custody to therapy.

From custody to therapy.


Sickle cell disease: clinical advances by the Murayama molecular hypothesis.


An approach to health in Latin America.

An approach to health in Latin America.


Variations of illness incidence in the Navy population.


An alternative method of flap reflection of mandibular third molars.


Case for diagnosis.

Case for diagnosis.


right aortic arch and isolated valvular pulmonary stenosis: case report.


Idiopathic hypertrophic subaortic stenosis: variability of obstruction. Association with mild aortic valvular stenosis.


Bee stings in operational theatres.

Bee stings in operational theatres.


Wound healing with ordinary adhesive tape. A clinical and experimental study.


Treatment of donor sites. A controlled trial with fucidin gauze.


Increase in the toxicity of organophosphorus insecticides to house flies due to polychlorinated biphenyl compounds.


Autotrophic growth of hydrogen bacteria in continuous culture.


The growth behavior of Azotobacter chroococcum in association with some microorganisms in the soil.


Dynamics of spermiogenesis in Drosophila melanogaster. II. Coiling process.


A comparative analysis of middle-ear function in non-mammalian vertebrates.


Non-experimental aural pathology in the baboon.


Immunology of bovine heart valves. I. Cross-reaction with the C-polysaccharide of Streptococcus pyogenes.


Immunoglobulins A, G, and M in synovial fluid in rheumatoid arthritis. Reactive synovitis of local origin and in post mortem synovial fluid.


A free interface diffusion technique for the crystallization of proteins for x-ray crystallography.


Dose distribution and stability of radiotherapy electron beams from a linear accelerator.


The effects of disodium ethane-1-hydroxy-1, 1-diphosphonate on adjuvant induced arthritis in rats.


The nature of the bone mineral tissue--complexed chromium interaction.


Antibacterial activity of nifuratel in urine and serum. The minimum inhibitory concentrations of nifuratel for 205 randomly selected isolates from urinary tract infections were tested by tube dilution. Of these, 177 (86.3%) were resistant to more than 6 mug/ml and 140 of 141 (99.3%) strains of Escherichia coli were resistant to more than 3 mug/ml. Urine levels of nifuratel were examined in two groups: one group had 400 mg given once and the other group had 2 g given over 24 hours. In both groups samples of urine were collected every hour for seven hours after the last dose. After one 400-mg dose the maximum urine level achieved by any subject was 2.0 mug/ml and the mean maximum level was 0.75 mug/ml. With the 2 g total dose, the maximum level noted was 4 mug/ml and the mean maximum level was 1.8 mug/ml. No measurable inhibition was noted in any of the blood samples removed at one and a half to two hours after the last dose.


Prognostic factors in the persistence of posttraumatic epilepsy.


Determination of p-hydroxyphenoxyacetic acid in phenoxymethyl penicillin fermentations.


The electrical activity in the motor cortex that accompanies voluntary movement.


Distribution of ventilation in isolated lungs: role of lobar mechanical properties and transpulmonary pressure gradient.


The role of inflammatory macrophages in experimental acute chagasic myocarditis.


Pathology of spontaneous cases of avian transmissible tubulonephrosis.


Ultrastructure of human C1q protein.

Ultrastructure of human C1q protein.


Role of base composition in the electrophoresis of microbial and crab DNA in polyacrylamide gels.


Technical requirements for the recording of significant social signals in squirrel monkey groups.


Lassa fever. Virological and serological studies.


The ultrastructure of red cells infected by Plasmodium falciparum in man.


A revision of Trypanosoma (Schizotrypanum) cruzi strains from British Honduras, and the importance of strain characteristics in experimental chemotherapy of Chagas's disease.


Preliminary studies on the efficacy of Bayer 2502 (lampit) for treatment of Trypanosoma cruzi (strain 7) infection in CF1 mice.


Home health services in Massachusetts, 1971: their role in care of the long-term sick.


Isolation of immunoglobulin and fragment from donkey anti-Russell's viper serum.


Isolation of pure fractions of viable calf kidney tubules and glomeruli. "In vitro" culture, immunochemical and esterase zymogram analysis.


Immunofluorescent localization of calf kidney-specific antigens with monospecific antisera and with specific antigen-antibody immunoprecipitation lines.


The fine structure of corticosteroid-covered, human dentine.


Quantitative ultrastructure of intradental nerve fibres in marmosets.


Electron-optic analyses of hypomineralized amelogenesis imperfecta in man.


Lignocaine overdose and ampoule labelling.


Tuberculous ulcer of the skin.

Tuberculous ulcer of the skin.


Unusual case of paratyphoid fever.

Unusual case of paratyphoid fever.


Disodium cromoglycate in allergic respiratory disease.


Techniques in megavoltage radiotherapy. 4. Carcinoma of the bronchus.


Uncommon arterio-venous fistulae.

Uncommon arterio-venous fistulae.


Genetic analysis of sex chromosomal meiotic mutants in Drosophilia melanogaster. A total of 209 ethyl methanesulfonate-treated X chromosomes were screened for meiotic mutants that either (1) increased sex or fourth chromosome nondisjunction at either meiotic division in males; (2) allowed recombination in such males; (3) increased nondisjunction of the X chromosome at either meiotic division in females; or (4) caused such females, when mated to males heterozygous for Segregation-Distorter (SD) and a sensitive homolog to alter the strength of meiotic drive in males.-Twenty male-specific meiotic mutants were found. Though the rates of nondisjunction differed, all twenty mutants were qualitatively similar in that (1) they alter the disjunction of the X chromosome from the Y chromosome; (2) among the recovered sex-chromosome exceptional progeny, there is a large excess of those derived from nullo-XY as compared to XY gametes; (3) there is a negative correlation between the frequency of sex-chromosome exceptional progeny and the frequency of males among the regular progeny. In their effects on meiosis these mutants are similar to In(1)sc(4L)sc(8R), which is deleted for the basal heterochromatin. These mutants, however, have normal phenotypes and viabilities when examined as X/0 males, and furthermore, a mapping of two of the mutants places them in the euchromatin of the X chromosome. It is suggested that these mutants are in genes whose products are involved in insuring the proper functioning of the basal pairing sites which are deleted in In(1)sc(4L)sc(8R), and in addition that there is a close connection, perhaps causal, between the disruption of normal X-Y pairing (and, therefore, disjunction) and the occurrence of meiotic drive in the male.-Eleven mutants were found which increased nondisjunction in females. These mutants were characterized as to (1) the division at which they acted; (2) their effect on recombination; (3) their dominance; (4) their effects on disjunction of all four chromosome pairs. Five female mutants caused a nonuniform decrease in recombination, being most pronounced in distal regions, and an increase in first division nondisjunction of all chromosome pairs. Their behavior is consistent with the hypothesis that these mutants are defective in a process which is a precondition for exchange. Two female mutants were allelic and caused a uniform reduction in recombination for all intervals (though to different extents for the two alleles) and an increase in first-division nondisjunction of all chromosomes. Limited recombination data suggest that these mutants do not alter coincidence, and thus, following the arguments of Sandler et al. (1968), are defective in exchange rather than a precondiiton for exchange. A single female mutant behaves in a manner that is consistent with it being a defect in a gene whose functioning is essential for distributive pairing. Three of the female meiotic mutants cause abnormal chromosome behavior at a number of times in meiosis. Thus, nondisjunction at both meiotic divisions is increased, recombinant chromosomes nondisjoin, and there is a polarized alteration in recombination.-The striking differences between the types of control of meiosis in the two sexes is discussed and attention is drawn to the possible similarities between (1) the disjunction functions of exchange and the process specified by the chromosome-specific male mutants; and (2) the prevention of functional aneuploid gamete formation by distributive disjunction and meiotic drive.


Isolation of recessive third-chromosome temperature-sensitive mutants in Drosophilia melanogaster.


Carbonic anhydrase polymorphism in a New Jersey population of the white-footed mouse Peromyscus leucopus. Two electrophoretic forms of erythrocytic carbonic anhydrase were found to be controlled by one autosomal locus with two codominant alleles, CA(f) and CA(8). The gene frequencies for the CA(f) and CA(8) alleles were found to be.15 and.85, respectively, in a sample of 53 mice from Middlesex County, New Jersey. The observed genotypic frequencies indicated that the population was in Hardy-Weinberg equilibrium.


ABO incompatibility as a cause of spontaneous abortion: evidence from abortuses.


Immunological studies in congenital nephrosis.


When "refractory" angina has an unsuspected cause.


Distribution of rabbit IgG in the accessory sexual gland tissues of the male rabbit.


Direct printing of unstained, water immersed immunodiffusion slides.


Antigenic relationship between the C4 inactivating substance produced by KB cell cultures and the first component of human complement (C1).


Survival of common terrestrial microorganisms under simulated Jovian conditions.


The transfer of antibodies by neonates and adults.


Application of the erythrocyte glutathione reductase assay in evaluating riboflavin nutritional status in a high school student population.


Effect of oral lactobacillus feedings on fecal lactobacillus counts.


Australia antigen in normal population and hepatitis patients.


Metabolism and aging of the villus epithelial cell in tropical sprue.


Intestinal absorption in vivo of micellar and nonmicellar lipid.


Hemopoiesis in the pig-tailed monkey Macaca nemestrina during chronic altitude exposure.


Zonal differences in permeability of the skin of some anuran Amphibia.


Relationship of blood pressure and heart rate to body temperature in baboons.


Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid.


X-chromosome linked inheritance of decreased thyroxine-binding globulin.


Biliary atresia associated with prenatal infection by Listeria monocytogenes.


Variations in the membranes of Streptococcus faecalis related to different cultural conditions.


The phenoloxidases of the ascomycete Podospora anserina. X. Electron microscopic studies on the structure of laccases I, II and III.


State of the rigid-layer in celll walls of some gram-negative Bacteria.


Plurality of human serum albumin.

Plurality of human serum albumin.


Hepatic dysfunction during diabetic ketosis.


Antimicrobial activity of a series of new 5-nitro-2-furaldehyde aminoacethydrazones.


Double blind crossover study of cromolyn sodium inhibition of aerosol antigen challenge.


Undiagnosed tuberculosis in a general hospital.


Reverse passive respiratory reactions due to anti-IgE in rhesus monkeys.


Serum IgD concentrations in sarcoidosis and tuberculosis.


A comparative evaluation of two hypnotic agents in genral practice patients with insomnia.


Experimental cutaneous leishmaniasis. II. Effects of immunosuppression and antigenic competition on the course of infection with Leishmania enriettii in the guinea-pig.


The spectrum of benign to malignant lymphoproliferation in Sjögren's syndrome.


A clinical trial of a benzazepine (SCH 12679) in acute schizophrenic patients.


The use of AL-1612 on anxious neurotic outpatients: a preliminary study.


A controlled study of haloprogin and tolnaftate in tinea pedis.


Effects of catecholamine synthesis inhibition on ethanol narcosis in mice.


Restitution of function in the CNS: the pathologic grasp in Macaca mulatta.


Haemonchus contortus: enzymes. II. Fructose diphosphate aldolase.


Amino acid substitution in an amidase produced by an acetanilide-utilizing mutant of Pseudomonas aeruginosa.


Actinomycosis of the maxilla: review of literature and report of case.


Genetic and transfection studies with B. subtilis phage SP50. 3. Biological effects of DNA cleavage and the physical basis of the map.


Nalidixic acid does not inhibit bacterial transformation.


Development of mammalian sulfur metabolism: absence of cystathionase in human fetal tissues.


Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.


An ultrastructural comparison of normal and Hurler syndrome dermal fibroblasts.


Effect of calcium and chromium chelates of ethylenediaminetetraacetate on intestinal permeability and collagen metabolism in the rat.


Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey.


Low concentration antibodies. VI. Immunogenesis of anti-f. A new look at the Rh system.


Implications of individual and small group learning systems in medical education. Report of a WHO Study Group.


Effect of phencyclidine hydrochloride on certain cardiorespiratory values of rhesus monkey (Macaca mulatta).


Calcium inhibition of antibacterial activity of kanamycin.


Isolation and characteristics of small, soluble photoreactive fragments of Rhodospirillum rubrum.


Congenital coloboma of the upper eyelid.


Multiple alleles and gene divergence in natural populations.


Does the fixation of neutral mutations form a significant part of observed evolution in proteins?


How much room is left for non-Darwinian evolution?


Chromosomal localization of repetitive DNA.


Change in repeated DNA in evolution.

Change in repeated DNA in evolution.


Glucose-stimulated insulin secretion during "remission" of juvenile diabetes.


Prolactin and growth hormone concentrations in the plasma of the toad Bufo bufo (L.) following ectopic transplantation of the pars distalis.


Ionic requirements for melanophore-stimulating hormone (MSH) release.


Innervation of blood vessels in the dental pulp.


A technique for Curie point pyrolysis gas chromatography of complex biological samples.


Caffeine bleaching of Stentor coeruleus.


Stabilization of dissociable IgA2 proteins by secretory component.


Secretory Newcastle disease virus antibodies from chicken respiratory tract.


Inhibition of antigen-stimulated in vitro proliferation of thymic dependent chicken spleen cells by specific antibody.


Defective in vitro spleen cell proliferative response to antigens in agammaglobulinemic chickens.


Tumor formation and paraprotein production by mouse plasmacytoma cells transplanted to hamsters.


Chicken immunoglobulin resembling  A.

Chicken immunoglobulin resembling  A.


The role of cystography in thio-tepa toxicity.


Acalculous cholecystitis--a possible complication of parenteral hyperalimentation: report of a case.


The necessity and control of hospitalization.


Reactions of pulpotomized teeth to zinc oxide and formocresol-type drugs.


Parathyroid diseases and irradiation.

Parathyroid diseases and irradiation.


Adjuvant chemotherapy in resectable cancer of the colon and rectum.


Electroretinographic evidence for a photopic system in the rat.


Radial immunodiffusion of spinal fluid: diagnostic value in multiple sclerosis.


A preliminary report of an indirect fluorescent antibody test for detecting antibodies to cysts of Pneumocystis carinii in human sera.


Clindamycin: clinical and laboratory evaluation of parenteral therapy.


Immunochemical analyses of cellular DNA.


Interaction of ribulose diphosphate carboxylase with 2-carboxyribitol diphosphate, an analogue of the proposed carboxylated intermediate in the CO 2  fixation reaction.


Inhibition of measles virus replication and RNA synthesis by actinomycin D.


Inhibition of fatty acid synthetases by the antibiotic cerulenin.


Amino acid sequence of human erythrocyte carbonic anhydrase B.


High content of docosahexaenoate and of total diacylglycerol in retina.


Glucono- -lactonase from Escherichia coli.


The influence of cations on spontaneous and chemically induced efflux of noradrenaline from perfused rat hearts.


Multiple forms of human adenosine deaminase. I. Purification and characterization of two molecular species.


Water-insolubilisation of glycoside hydrolases with cross-linked poly(acryloylaminoacetaldehyde dimethyl acetal) (Enzacryl Polyacetal).


Supplementary cues and delayed-alternation performance of frontal monkeys.


Efficiency of human monozygotic twins in studies of blood lipids.


Comparative evaluation of the results of cup arthroplasty and total hip replacement.


Sequential degradation of insulin by rat liver homogenates. Insulin was incubated with rat liver homogenate in the presence of glutathione. The products formed were examined by chromatography on a Sephadex G-75 column, with 50% acetic acid as eluent. The results show that insulin is degraded by rat liver homogenates in sequential order: first, a splitting of insulin into A and B chains by glutathione-insulin transhydrogenase, followed by proteolysis of the resulting polypeptides to small molecular weight components.


Quantitative abnormalities of allotypic genes in families with primary immune deficiencies. Genetic antigens of human immunoglobulin G (Gm factors) were measured in members of the families of selected patients with primary immunodeficiency. The sera of seven out of 27 heterozygous relatives had either deficient concentrations of one Gm allotype or an unbalanced ratio of Gm(f)/Gm(a). Since these markers for allelic IgG1 genes are found in almost equal amounts in normal heterozygous persons, the results suggested that there was a quantitative deficiency in the expression in serum of one Gm gene. In several families allotype abnormalities were found in three successive generations; in one instance the quantitative defect appeared to segregate independently of the Gm genes. The experimental data failed to support a recessive gene hypothesis, in that too few of the close relatives had evidence indicating that they were carriers of defective Gm genes. The results were interpreted as consistent with an inherited regulatory defect in certain families with this disorder.


Dysplasia epiphysealis hemimelica: a case simulating an intra-articular body.


The triplane distal tibial epiphyseal fracture.


In vitro vs in vivo chromatographic profiles of carbaryl anionic metabolites in man and lower animals.


Rheumatoid factors in Salmonella and Schistosoma infections.


Intravenous pyelograms and associated histopathology of baboons infected with Schistosoma haematobium (Nigerian strain).


An evaluation of the Casoni test in human hydatidosis using an antigen solution of low nitrogen concentration.


A case of natural infection of S. haematobium in a Senegalese baboon (Papio sp.).


Pathogenicity of Haemoproteus columbae.

Pathogenicity of Haemoproteus columbae.


Studies on the pathology of experimental sparganosis.


What is Schistosoma intercalatum Fisher, 1934?


Studies on the effects of bacteria on experimental schistosome infections in animals.


Tube feeding using a food pump.

Tube feeding using a food pump.


The occurrence of homogeneous antibodies and antigenic selection of kappa light chains to streptococcal carbohydrates in Monash rabbits.


Factors affecting the absorption of vitamin B 12 .


Effects of propranolol, phentolamine and methyl atropine on cardiovascular function in the squirrel monkey during behavioral experiments.


Effects and treatment of malabsorption in childhood.


The form and function of the carpal bones in some arboreally adapted mammals.


Structure and distribution of polysaccharides in the salivary glands of the common marmoset (Callithrix jacchus).


The inactivation of bradykinin in the pulmonary circulation of isolated lungs. 1. The isolated lungs of guinea-pigs, rats and dogs, perfused with Krebs bicarbonate solution via the pulmonary artery, inactivated 95, 98 and 99% respectively of the bradykinin infused through them.2. This inactivation process was not inhibited by 2-mercaptoethanol (1 mM) or EDTA (500 muM).3. The inactivation was inhibited by 2:3-dimercaptopropanol (100 muM), N-ethylmaleimide (100 muM), and several of the bradykinin potentiating peptides from Bothrops jararaca, in both natural and synthetic forms.4. The effect of these compounds, 2-mercaptoethanol, EDTA, 2:3-dimercaptopropanol, N-ethylmaleimide and Bothrops peptides on the pulmonary bradykininase activity is the same as their effect on pulmonary angiotensin I converting enzyme.


The central stimulant and potential antiparkinsonism effects of 2(p-nitrobenzylthio)-imidazoline (3H)-HCl.


Addiction and the community. (Narcotic substitution therapy).


Biochemical and immunological comparison of aliphatic amidases produced by Pseudomonas species.


The characterization of dipeptidases from Escherichia coli.


Comparison of homogenous freeze-dried and fresh autogenous bone grafts in the monkey mandible.


Revascularization and bone healing after maxillary corticotomies.


Long-term care of schizophrenia.

Long-term care of schizophrenia.


Total body potassium in normal children.


Capping of the inflamed pulp.

Capping of the inflamed pulp.


Effect of bacteria on intestinal uptake of vitamin B 12 . II. The consequences of in vitro preincubation of B 12  with pure bacterial populations.


A clinical evaluation of glibenclamide (HB 419, "Daonil") a new antidiabetic sulphonylurea.


Studies of splenomegaly in rodent malaria. 3. Protein calorie malnutrition and splenomegaly in mice infected with Plasmodium berghei yoelii.


The liver in pre-kwashiorkor and kwashiorkor-marasmus syndromes.


Burkitt's lymphoma and malaria.

Burkitt's lymphoma and malaria.


Tissue-binding antibodies in tropical populations.


Some researches in the Americas with triatomid vectors of Chagas's disease.


Serological studies on animals experimentally infected with African trypanosomes.


Partial purification of immunogenic (protective) antigens of Trypanosoma brucei brucei.


Serological reactions in different animal species after an inoculation with T. brucei.


Studies on the biochemistry of the blood and intracellular stages of Trypanosoma cruzi. Preliminary studies on the isolation of intracellular stages from rats.


Enterococci in diarrhoea of neonates.

Enterococci in diarrhoea of neonates.


Transmission of Plasmodium falciparum from monkey to monkey by the bite of infected Anopheles freeborni mosquitoes.


Reproducibility in bacteriophage sensitivity pattern of Pseudomonas aeruginosa.


Bacteriophage typing and serogrouping of Pseudomonas aeruginosa from animals.


The influence of preparation technique, humidity and irradiation conditions on radiation inactivation of Streptococcos faecium, strain A 2 1.


The synthesis of phospholipase C by Bacillus cereus and its relation to sporulation.


Chromosome replication related to cell division and increase in cell mass in synchronized cultures of Neisseria meningitidis.


Four new Escherichia coli O antigens, O148, O151, O152, O153, and one new H antigen, H50, found in strains isolated from enteric diseases in man with a discussion on the future numbering of K antigens.


Two new Escherichia coli O antigens, O150 and O157, and one new K antigen, K92, in strains isolated from veterinary diseases.


The location of carbonic anhydrase in a strain of Neisseria flava.


Virologic studies of acute respiratory disease in young adults. V. Coronavirus 229E infections during six years of surveillance.


Pharmacological studies on 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo-(6,7)-1,4-diazepino(5,4-b)-oxazol-6-one (CS-370), a new psychosedative agent.


Effect of trans-1,4-bis-2-dichlorbenzyl-aminoethyl-cyclohexane (AY-9944) on the experimental brain tumor G26A.


Agglutination of bacterial spheroplasts. I. Effect of concanavalin A.


Inherited high serum levels of a functionally deficient complement esterase inhibitor associated with hereditary angioedema.


Family studies in systemic lupus erythematosus (SLE). VII. Serum immunoglobulins: IgG concentrations in relatives and spouses.


Properties of single-stranded RNA synthesized by a crude RNA polymerase fraction from barley leaves infected with brome mosaic virus.


Precipitin reactions between polyribonucleotides and heat labile serum factors.


Immunoglobulin M: identification of an unusual fragment following high temperature trypsin proteolysis.


Immunoglobulin receptors on a mouse mast cell tumor.


The localization of oligosaccharides in a human IgM protein.


The antibody response of rabbits to soluble mouse H-2 antigens.


Fractionation of the antigens of canine prostatic fluid.


False positive tests for hepatitis-associated antigen in blood donors caused by antibodies to ruminant serum proteins.


The immunogenicity of adenovirus type 5 structural proteins.


Immunochemical cross-reactions of human amyloid proteins with human immunoglobulin light polypeptide chains.


Studies on immunoglobulins of mink: definition of IgG, IgA and IgM.


Scanning electron microscopy of L-phase streptococci. I. Development of techniques.


A three-dimensional model of membrane ruffling from transmission and scanning electron microscopy of cultured monkey kidney cells (LLCMK 2 ).


Marble spleen disease in ring-necked pheasants: demonstration of agar gel precipitin antibody in pheasants from an infected flock.


The intravenous use of fat for the total parenteral nutrition of the infant.


Skin infections in Vietnam.

Skin infections in Vietnam.


Apnea and muscle weakness in two premature infants: descriptive case reports.


Acquired pelvic arteriovenous fistula: case report and literature review.


Some relations of medical psychology and military psychology.


Prevalence of suicidal ldeation and behavior among basic trainees and college students.


Rational drug procurement or caveat emptor?


Fluid and electrolyte therapy.

Fluid and electrolyte therapy.


Pharmacology of the placenta.

Pharmacology of the placenta.


Visual pattern analysis in machines and animals.


Intestinal uptake of macromolecules: effect of oral immunization. Animals were orally immunized with horseradish peroxidase and bovine serum albumin, and absorption of these antigens was studied. In comparison with controls, a consistent and significant decrease in peroxidase uptake was noted in both germ-free and conventional rats immunized with peroxidase; a similar decrease in serum albumin uptake was also noted in animals immunized with serum albumin. There was no difference in the uptake of an unrelated macromolecule. These observations suggest that local immunization interferes specifically with the intestinal uptake of macromolecular antigens.


Hepatic allotransplantation in the baboon. IV. Further studies with the post-transplant administration of donor bone marrow and a soluble donor splenic antigen.


The medical uses of ionizing radiation and radioisotopes.


Passive and active enhancement in baboon liver allografting.


Ocular manifestations of the Meckel syndrome.


Absorption, distribution, excretion and metabolism of tiaramide hydrochloride: a new anti-inflammatory drug.


Biological magnification of a polychlorinated biphenyl (Aroclor 1254) from water by aquatic invertebrates.


A solid-phase radioimmunoassay for a thermostable adrenal-specific antigen.


Modification of pentobarbital sleeping times in rats following chronic PCB ingestion.


Studies on thermostable liver-specific antigens.


Some environmental consequences of the use of antibiotics: or 'what goes up must come down'.


Preparation of dextran-protein conjugates and studies of their immunogenicity.


Effect of glutaraldehyde on the outer layers of Escherichia coli.


The semi large-scale production, extraction, purification and properties of an antibiotic produced by Pseudomonas fluorescens strain 175.


The use of density gradient centrifugation for the separation of germinated from nongerminated spores.


Anthropometry in the differential diagnosis of protein-calorie malnutrition.


Reduction in serum CO 2  during hyperalimentation.


The role of nurses.

The role of nurses.


Some properties of rat liver ribosomal subunits prepared by EDTA- and by puromycin KCl-treatment.


An autoradiographic study of the temporomandibular articulation in the growing Saimiri sciureus monkey.


Studies of adaption to experimental change in form and growth of the Rhesus monkey.


Evaluation of disodium cromoglycate in intrinsic and extrinsic asthma.


Isolation of specific and nonspecific components from purified protein derivative.


Lymphocyte transformation. An aid in the diagnosis of tuberculosis in patients with nonreactive skin tests.


Isolation from media of two bacteriophages, protamylase-H37Rv (PH) active against Mycobacterium tuberculosis.


The tuberculin skin test.

The tuberculin skin test.


The influence of sympathetic nervous activity on cerebral blood flow.


Variation in response to anticonvulsants in a group of epileptic patients.


Phenylethylmalonamide (PEMA). An important metabolite of primidone.


Quantitative relationships between toxic doses of antitumor chemotherapeutic agents in animals and man.


Working session report: laboratory of toxicology.


The pharmacokinetics of fluoride in mouth rinses as indicated by a reference substance (51Cr-EDTA).


Abnormal automaticity in canine Purkinje fibers focally subjected to low external concentrations of calcium.


Trypanosoma lewisi: production of exoantigens during infection in the rat.


Babesia argentina: immunogenicity of plasma from infected animals.


Fecal pseudomonas aeruginosa as a cause of the blue diaper syndrome.


Surface charge on plasmodium knowlesi and P. coatneyi-infected red cells of Macaca mulatta.


Syndrome of ocular and facial anomalies, telecanthus, and deafness.


Blue diapers caused by pyocyanin produced by P. aeruginosa.


Action of supermutagens on the transforming DNA of Bacillus subtilis.


The nature of reversion of a dominant gene of Drosophila melanogaster.


Congenital diverticulum of the pharynx simulating esophageal atresia.


Post-radiation repair at specific loci in Drosophila spermatids.


Perfusion of melanoma. 105 isolated perfusions in 92 patients.


Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.


Chemotherapy for recurrent carcinoma of the breast.


Hormones, chemotherapy, and the breast cancer patient.


Low prevalence of antibody to Trypanosoma cruzi in Georgia.


Response to thyrotropin releasing hormone in man: feedback inhibition by thyroid hormone.


Behavioral effects of telestimulating hypothalamic reinforcement sites in freely moving rhesus monkeys.


The effects of selective caudate lesions in infant and juvenile Rhesus monkeys.


Changes in brain and sciatic nerve composition with development of the rhesus monkey (Macaca mulatta).


Hypersensitivity pneumonitis due to exposure to budgerigars.


Demonstration of thyroglobulin in the thyroid glands of obese strain and normal white leghorn chicken embryos.


Immunologic identification of human seminal plasma protease inhibitor in cervical mucus.


Allergic respiratory reactions in bird fanciers provoked by allergen inhalation provocation tests. Relation to clinical features and allergic mechanisms.


Enzyme induction of organic nitrates I: nitroglycerin in vivo experiments.


Renal contribution to overall metabolism of drugs. I. Conversion of benzoic acid to hippuric acid.


Renal contribution to overall metabolism of drugs. II. Biotransformation of salicylic acid to salicyluric acid.


Government support of nursing-home care.


Conformational changes in ribonuclease during photodynamic inactivation.


Hepatitis-associated antigen and antibody in Swedish blood donors. Relation to liver disease.


Studies on Australia antigen in India.

Studies on Australia antigen in India.


Unexplained appearance of antibody in an Rh null  donor.


Re-immunization of sensitized women.

Re-immunization of sensitized women.


Tracing and treatment of children with essential familial hypercholesterolemia.


The adenine nucleotide content of rat liver during infusions of carbohydrates and polyols.


Immunoglobulin M concentration in sera from sleeping sickness patients during and after treatment.


Avian blood coccidians.

Avian blood coccidians.


The metabolism of the malaria parasite and its host.


The pathogenesis of mammalian malaria.

The pathogenesis of mammalian malaria.


Ludwig's angina. Case report, with review of bacteriology and current therapy.


Recrudescent melioidosis associated with diabetic ketoacidosis.


Pharmacological study of piroheptine, a new antiparkinson drug, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine. I. Effects on drug-induced tremor and catatonia, and on adrenergic actions.


The influence of inorganic ions on the uptake and retention of tritiated noradrenaline by isolated perfused rat hearts.


Effect of copper on urate oxidase.

Effect of copper on urate oxidase.


Maintenance of energy-linked functions in rat-liver mitochondria aged in the presence of nupercaine.


Pigments of Pseudomonas species. IV. In vitro and in vivo conversion of 5-methylphenazinium-1-carboxylate into aeruginosin A.


Method of visualization of matrix-bound proteins. Leucine aminopeptidase bound to Sepharose and Sephadex beads.


Phosphohexose isomerase polymorphism in macaques.


Clinical studies with thyrotropic releasing hormone. A test of anterior pituitary functional reserve.


Decreased percentage of polymorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients. Mice inoculated with brain homogenates from multiple sclerosis (MS) cases showed marked changes in their leukocyte differential counts, with a decrease in per cent polymorphonuclear neutrophils (PMN) and an increase in the per cent lymphocytes. These changes were based upon an absolute decrease in the number of circulating PMN. The decrease in PMN percentages was apparent at 16 hr after infection and persisted for at least 11 months. The factor responsible for the decrease in PMN was (a) recoverable from 12 hr to 8(1/2) months after inoculation, (b) present in human brain homogenate at a concentration of 3 x 10(12), and (c) between 25 and 50 nm in diameter. Inoculation of 100 units of factor into mice and subsequent titration showed that the factor had undergone a net increase in the mouse of at least 10(9)-fold. The factor causing the PMN decrease was found in all MS material thus far tested: three brains, one spleen, three sera, and two cerebrospinal fluid (CSF) from nine cases of MS. The factor was not found in normal human material that included two brains, one spleen, two sera, and two CSF.


Immunological study on conception--the detection of antibody to human trophoblast by immune adherence.


Health and general systems of financing health care.


Studies on ultrastructure and immunology of the insulitis in rabbits immunized with insulin.


The computer in chemical research--an introduction.


Computer systems for chemical research.

Computer systems for chemical research.


[Computer-aided analysis of organic mass spectra].


Data processing in gas chromatography.

Data processing in gas chromatography.


Use of a computer in nuclear magnetic resonance spectroscopy.


Automated x-ray structure determination as an analytical method.


Glossary of some computer terms.

Glossary of some computer terms.


Application of computers to MO theory and chemical kinetics.


Metal ion function in carbonic anhydrase.


Total synthesis of ( ,  - 14 C 2 )uroporphyrin 3.


On the biosynthesis of heme and vitamin B 12  from ( ,  - 14 C 2 )uroporphyrinogen 3.


Synthesis of stable 1-benzothiepins.

Synthesis of stable 1-benzothiepins.


The "sulfoxide bond".

The "sulfoxide bond".


L-Asparaginase production by Streptomyces griseus. Streptomyces griseus ATCC 10137 synthesizes about 1 IU of L-asparaginase/100 ml of a 4% peptone medium. The enzyme has a pH optimum of 8.5 which is comparable to that of the L-asparaginase derived from Escherichia coli which has antitumor properties.


Diagnostic factors in adult males following initial seizures. A three-year follow-up.


Imipramine in epilepsy.

Imipramine in epilepsy.


Intractable seizures. Treatment with a new benzodiazepine anticonvulsant.


Identification and genetic control of two rabbit high-density lipoprotein allotypes.


[Multiple D-loops in Tetrahymena mitochondrial DNA].


Phospholipase C from Bacillus cereus and its use in studies of tissue thromboplastin.


Biological aspects of the interaction between gentamicin and carbenicillin.


Schistosomicidal 5-nitro-4-thiazolines.

Schistosomicidal 5-nitro-4-thiazolines.


Variability of DNA content in individual cells of Bacillus.


Induction of the feline oncornavirus associated cell membrane antigen in human cells.


Simian tumour virus proliferation in inoculated Macaca mulatta.


Blood flow to the liver and spleen during endotoxin shock in the baboon.


The ventilatory response to hemorrhagic shock and resuscitation.


Hereditary hypoprothrombinaemia. True deficiency of factor II.


Chemical synthesis of polynucleotides.

Chemical synthesis of polynucleotides.


Perspectives in nonsteroidal anti-inflammatory agents.


Structure and function of chromosomal nucleohistones.


A rapid method for determination of the optical purity of amino acids.


Metabolism of (4-14C-1,2-3H) testosterone by placental microsomes from baboon: identity of new metabolites in studies of aromatization.


Estrogens, progesterone and chorionic gonadotropin in pregnant rhesus monkeys.


Prolactin releasing factor in porcine and rat hypothalamic tissue.


Diabetic ketoacidosis: evidence for C-peptide and proinsulin secretion following recovery.


Quantitative determination of TBG in familial elevation of serum thyroxine binding capacity of TBG.


Thyrotropin releasing hormone (TRH) studies in patients with thyroid cancer.


Elimination of TRH in man.

Elimination of TRH in man.


A biological method for diagnosis of different forms of arterial hypertension.


Colonization resistance of the digestive tract and the spread of bacteria to the lymphatic organs in mice. After oral contamination of conventional mice with high doses of Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa the contaminant was recovered in abnormally high concentrations from the duodenum and caecum during the first few days. In this initial colonization phase, evidence of spread was obtained by culturing the cervical and mesenteric lymph nodes and spleen. Longer after contamination the intestinal concentration decreased to normal and spread stopped. In orally antibiotic-treated mice, the situation seen during the initial colonization phase in conventional mice occurred after a much lower oral contamination dose and persisted during the entire observation period of 2 weeks.


Projection of group I muscle afferents to the postcentral gyrus of the rhesus monkey.


The function of single cells of the monkey visual cortex in visual stabilization.


The pharmacology of hallucinogens.

The pharmacology of hallucinogens.


Effects of delta-9-tetrahydrocannabinol on temporal and auditory discrimination performances of monkeys.


Retinal and optic nerve complications in a high dose irradiation technique of ethmoid sinus and nasal cavity.


Management and prognosis of squamous-cell carcinoma of the tonsillar region.


Cytopathogenic process in Junin virus infected vero cells.


Portacaval shunt for glycogen storage disease: value of prolonged intravenous hyperalimentation before surgery.


Animal models for the study of progression and regression of atherosclerosis.


A contribution to paresis spastica in cattle.


Production of tryptamine from tryptophan by ruminal fluid in vitro.


Response to heparin of spontaneous disseminated intravascular coagulation in the dog.


The effect of L(+)-lactate on rat and horse adipose tissue in vitro.


Action exerted on the incubation indices of eggs by folcysteine administered to breeding poultry.


The role of prefrontal lobes in psychonervous memory in vertebrates. The memory phenomena are classified into image memory, emotional memory and conditioned reflex memory. It is assumed that prefrontal area is critically involved in the image memory, and in particular, in short-term image memory. On the other hand, both emotional and conditianed reflex memory do not depend on the prefrontal area but they are controlled by other parts of the neocortex and by paleocortex. The intimate nature of both short-term and long-term memory is discussed.


The effect of acetazolamide upon the regulation of the cerebrospinal fluid pH in the rat.


Autoradiographic distribution of volatile anesthetics within the brain.


Toxicity of L-asparginase in children with advanced leukemia.


Oral substitutes for insulin: modern appraisal of their action and indications.


Complications in diabetes and their management.


Blockade of insulin secretion by mannoheptulose.


Insulin secretion in sheep pancreatic autotransplants.


Insulin release in children with diet-treated diabetes.


Lipid disorders in diabetes mellitus.

Lipid disorders in diabetes mellitus.


Role of epinephrine in metabolic homeostasis of juvenile diabetes.


Serial plasma growth hormone levels in 33 diabetic patients in ketoacidosis coma: effect of sodium nicotinate.


Experience with a new hypoglycemic agent, glibenclamide, HB 419 (Daonil) in diabetes mellitus.


Diabetic membranopathy, a model for the mechanism of the so-called major complications of diabetes.


Peripheral tissue response to human diabetic sera.


A study of immunoglobulin levels among Singapore infants and children.


Scanning electron microscopic observations on the surface of the normal and spirochete-infested colonic mucosa of the rhesus monkey.


The postacrosomal region of the spermatozoa of man and Macaca arctoides.


The effect of caffeine and rapid cooling on smooth muscle.


Influence of fatty-acid composition of infant formulas on the development of arteriosclerosis and on the lipid composition of blood and tissues. II. Further lipid studies.


Chemistry and biochemistry of branched-chain sugars.


Photooxidation of 3,4-diethyl-2,5-dimethylpyrrole.


Amino acid analysis on the picomole scale.


X-ray photoelectron spectroscopy of iron-containing proteins--the valency of iron in ferredoxins.


Mesosomes in blue-green algae.

Mesosomes in blue-green algae.


DNA synthesis level and the occurrence of a third pregamic division as controlled by the position of nucleus in the cell.


Antimicrobial effects of Cellvibrio on blue-green algae.


Synthesized releasing hormones.

Synthesized releasing hormones.


Genetic duplication in the white-split interval of the X chromosome in Drosophila melanogaster.


Enhancement of cerebral flood flow by intermittent aortic occlusion.


Transcription rates of individual polytene chromosome bands: effects of gene dose and sex in Drosophila.


Hemodynamic and metabolic changes in experimental subarachnoid hemorrhage in monkeys.


Relief of arterial spasm associated with cerebral aneurysms.


The influence of systemic arterial pressure on CBF in conditions of intracranial hypertension.


Cerebral flood flow in experimental intracranial hypertension.


A comparison of extradural pressure with cerebrospinal fluid pressure.


Effect of regional cerebral blood flow of compression by a mass lesion.


Haemodynamic effects of experimental intracranial space-occupying lesions in passively-ventilated dogs and baboons.


Topographical organization of cortical efferent zones projecting to distal forelimb muscles in the monkey.


Peripheral afferent inputs to the forelimb area of the monkey motor cortex: input-output relations.


The optokinetic response under open and closed loop conditions in the monkey.


Equine infectious anemia: transmission from infected mares to foals.


Magnetic circular dichroism of Co (II) carbonic anhydrase.


A direct demonstration of the catalytic action of superoxide dismutase through the use of pulse radiolysis.


Properties of tyrosyl transfer ribonucleic acid synthetase from two tyrS mutants of Escherichia coli K-12.


Determination of the amino acid sequence of the monkey, sheep, and dog proinsulin C-peptides by a semi-micro Edman degradation procedure.


Ureteral diverticula.

Ureteral diverticula.


Size distribution changes in peripheral erythrocytes of the thoroughbred foal.


A contribution to the pathomorphology of vitamin A deficiency in chickens.


Some developmental aspects of the bovine fetal gut.


Inheritance of some of the economic traits of Italian Friesian cattle. II. Heritability of fat and protein contents of milk.


Cervical plexus lesions following post-operative radiation therapy of mammary carcinoma.


In-use contamination of intravenous solutions in flexible plastic containers.


Holoprosencephaly with median cleft lip. Clinical, pathological, and echoencephalographic study.


Acute tubular necrosis caused by exercise-induced myoglobinuria.


Teichoic acid antibodies in staphylococcal and nonstaphylococcal endocarditis.


Usefulness of "whole body counting" in pharmacokinetic studies.


Biotransformation of nitroglycerin by organic nitrate reductase.


Organic nitrates in angina pectoris.

Organic nitrates in angina pectoris.


The genetic structure of chromosomes carrying segregation-distorter.


The genetics of delta, a dominant sex-linked mutant of the mosquito, Culex tritaeniorhynchus.


Expression of the maternal effect involving the light locus in Drosophila melanogaster.


Model studies for azo dye carcinogenesis.


The effect of a gradient of transpulmonary pressure on the distribution of ventilation.


Coagulation and fibrinolysis in malaria.


Phthalate esters as environmental contaminants.


Induction of a reductive pathway for deoxyribonucleotide synthesis during early embryogenesis of the sea urchin. Cell-free extracts of Arbacia eggs (Arbacia punctulata) apparently do not contain an enzymatic system for the reduction of ribonucleotides to deoxyribonucleotides. However, during an interval of 5 hr after fertilization at 23 degrees , an enzymatic system is produced that is capable of catalyzing the reduction of CDP to dCDP in the presence of Mg(2+), ethylenediaminetetraacetate, ATP, and a reducing agent, dithiothreitol. The activity is first seen about 1 hr after fertilization, and reaches a peak at about 5 hr. The appearance of the ribonucleotide reductase is prevented by the addition of emetine or puromycin, inhibitors of protein synthesis, to the cells before fertilization. Inclusion of actinomycin D in the cell suspension at a concentration sufficient to inhibit synthesis of messenger RNA does not appreciably affect the production of the enzyme activity. Preexisting, maternal RNA is thus used for synthesis of reductase. Ribonucleotide reductase may, therefore, represent the first example of an enzyme system absent in unfertilized eggs that is produced in response to fertilization.


Induction of malate dehydrogenase isoenzymes in livers of young and old rats. The activity of cytoplasmic malate dehydrogenase (EC 1.1.1.27) of livers of young (9-10 weeks) and old (60-70 weeks) rats decreases after adrenalectomy and increases after administration of cortisone to adrenalectomized rats. These changes are significantly lower in old rats. The induction by cortisone is inhibited by actinomycin D. Adrenalectomy decreases and cortisone increases the activity of mitochondrial malate dehydrogenase of young rats, but not of old rats. Cortisone, however, induces both mitochondrial and cytoplasmic malate dehydrogenase of the regenerating liver at both the ages. Thus, impairment of the inducibility of mitochondrial malate dehydrogenase that occurs in old age is repaired in dividing cells. Immunological studies on purified malate dehydrogenase from young and old rats show that the molecular species of the enzyme is apparently the same at both ages. The changes in activities of the enzymes seen in old age may be due to changes in template activity of the corresponding genes, which apparently do not change with age.


Chromatin structure and the cell cycle.

Chromatin structure and the cell cycle. Pancreatic DNase I is used to probe the structure of chromatin isolated from synchronized HeLa cells. The degree to which DNA in chromatin is protected from DNase attack varies during the G(1), S, and G(2) phases of the cell cycle. In addition, the DNase sensitivity of chromatin from contact-inhibited African green monkey kidney cells differs from that of actively dividing, subconfluent cultures. These cell cycle-dependent chromatin changes were observed consistently at all enzyme concentrations (5000-fold range) and incubation times (15 min-2 hr) tested. The results indicate that the degree of complexing between DNA and chromosomal proteins changes during interphase, and they suggest that the chromosome coiling cycle of visible mitosis may extend in more subtle form over the entire cell cycle.


The mode of segregation of the bacterial cell membrane. The distribution of phospholipids from labeled parental membranes to progeny cells was studied by autoradiography and a minicell system. The minicell experiments showed that, during growth, the parental membrane is diluted at the same rate in cells and in minicells, which indicates that ends of cells are not different from the cylindrical portions with regard to the distribution of parental molecules. The same result was obtained after labeling heme-containing proteins with delta-aminolevulinic acid. The autoradiographic experiments indicate that the membrane segregates in about 250 subunits 4 x 10(4) nm(2) in size. These subunits appear to be conserved during growth.


Cell-bound myeloma proteins on the surface of myeloma cells: potential targets for the immune system. Rosette formation with 2,4,6-trinitrophenylated (Tnp)-sheep erythrocytes was used to demonstrate cell-bound myeloma proteins on cells from each of the eleven mouse plasmacytomas tested. Tnp-erythrocytes were bound directly by cells from two tumors (MOPC-315 and MOPC-460) that formed myeloma proteins with antihapten combining sites; rosette formation with cells from the other tumors required hybrid antibody fragments with one site specific for Tnp and the other specific for an appropriate immunoglobulin on the tumor cell surface. The cell-bound immunoglobulin of MOPC-315 and of MOPC-460 had the same heavy and light chains, idiotypic determinants, and ligand-binding specificities as the respective myeloma proteins secreted by these tumors. A variant tumor (MOC-315 NR) was grown from the small proportion of MOPC-315 cells (5-10%) that did not bind Tnp-erythrocytes directly: this tumor secreted only the light chain of protein 315, carried this chain on the cell surface, and resembled the variant tumors that arose, probably by immunoselection, in BALB/c mice challenged with MOPC-315 cells while making an immune response to the idiotype of protein 315.


Calcium-regulated parathyroid hormone peptidase. An enzymatic activity that catalyzes the conversion of glandular parathyroid hormone to a smaller-molecular-weight, biologically and immunologically active form of this hormone has been extracted from normal parathyroid and other porcine tissues. The product of the conversion has the immunologic characteristics of the hormone that occurs in peripheral serum and in tissue culture medium from parathyroid explants. The enzyme is activated by chelating agents and is inhibited by high calcium concentrations, suggesting that this enzyme may be important in the regulation of secretion or metabolism of the hormone.


Karyometrical and cytochemical studies of Harding-Passey melanoma and Horning-Mitchely kidney tumour. 3. Cytochemistry of some hydrolytic enzymes.


The metal (sulphide silver method) and enzyme cytochemical pattern of spermatozoa from bull, guinea-pig, hamster, mouse and rat.


The metal (sulphide silver method) and enzyme cytochemical pattern of rat spermatozoa after experimentally induced testicular lesions.


Unusual shape of "lysosomes" and their connections with intercellular spaces in the cholestatic rat liver cells.


Histochemical and biochemical studies on Co ++ -activated acylase in rodent tissues.


Investigations on acid phosphatase activity in hepatic acinus by means of a laser microanalyzer.


Karyometrical and cytochemical studies of Harding-Passey melanoma and Horning-Mitchely kidney tumour. I. Karyometrical studies.


Chemical plant protection--past, present, and future.


Carrier-bound biologically active substances and their applications.


Advances in acoustical holography.

Advances in acoustical holography.


Simple method for the synthesis of some boc-amino acids.


The biogenetically oriented total synthesis of camptothecin and 7-chlorocamptothecin.


Side-reactions arising on formation of cyclodipeptides in solid-phase peptide synthesis.


Simple new synthesis of N 6 -substituted adenosines and 2-aminoadenosines.


Reactivation of phosphorylated acetylcholinesterase--dependence upon activator acidity.


Solid-phase peptide synthesis on an inorganic matrix having organic groups on the surface.


Scanning electron microscopy of L-phase streptococci. II. Growth in broth and upon millipore filters.


The immunology of cytoplasmic antigens of mycobacteria.


Comparative effect of temperature on the induced synthesis of hydrogenase and enzymes of the benzoate oxidation system in psychrophilic and mesophilic bacteria.


Capsular antigens of Staphylococcus aureus. I. Further purification of the capsular antigen of a major capsular type of Staphylococcus aureus.


An examination of Penicillium notatum for the presence of Penicillium chrysogenum-type virus particles.


Enteral hyperalimentation with elemental diet.


The occurrence of hepatitis-associated antigen in a group of Canadian patients with leukemia. Serial blood samples from 37 Nova Scotian patients with different forms of leukemia and other malignant conditions of bone marrow and lymphoid tissue were tested for the hepatitis-associated antigen (HAA). Ten patients were found to be positive for HAA. Not only is there an increased incidence of HAA in this population group, but when present the antigen is carried for a longer period than in the normal individual. The increased incidence was completely unrelated to the blood transfusion histories of the patients.


Morphological and chromosomal characterization of three new continuous cell lines of Drosophila melanogaster.


Oxidation of branched chain  -ketoacids in Streptococcus faecalis and it's dependence on lipoic acid.


A sensitive and specific method for the determination of histomine in human whole blood and plasma.


Skeletal metabolism and body composition in acromegaly.


Competitive ligand-binding assay for measurement of thyronine-binding globulin (TBG).


Abnormalities in the release of TSH in response to thyrotropin-releasing hormone (TRH) in patients with disorders of the pituitary, hypothalamus and basal ganglia.


Crystalline antigen from the influenza virus envelope.


Site of nitrogenase activity in the blue-green alga Anabaena sp. L-31.


Trypanosoma cruzi--milk transmission of infection and immunity from mother to young.


An on-line circuit for extraction of average evoked potentials from periodic noise.


Some effects of irradiation on Theileria parva in the salivary glands of the tick Rhipicephalus appendiculatus.


Microsporidan parasites of Simulium ornatum Mg. in South England.


Entopolypoides macaci, a Babesia-like parasite in Cercopithecus monkeys.


Ultrastructural changes produced by the carcinogen, aflatoxin B 1 , in different tissues.


Correlation between column formation, thickness and rate of new cell production in guinea pig epidermis.


Lipid-containing substances in the basement membrane network of the human ciliary epithelium.


Brown discoloration of cartilage in phenacetin abuse.


Ethionine induced alterations in the Golgi apparatus and in the endoplasmic reticulum.


Ultraviolet photobiology of Kilham rat virus and the absolute ultraviolet photosensitivities of other animal viruses: influence of DNA strandedness, molecular weight, and host-cell repair.


Physical properties of blue-green algal virus SM-1 and its DNA.


An electron microscope study of infection by the blue-green algal virus SM-1.


Photosynthesis and the development of blue-green algal virus SM-1.


Haemophilia A and von Willebrand's disease in a Swedish family.


The cat-eye syndrome. Review and two further cases occurring in female siblings with normal chromosomes.


Brucella melitensis Rev. 1 and Brucella abortus 45-20 vaccines in goats: immunity.


Regression of corpus luteum in mares treated with an antiserum against an equine pituitary fraction.


Catabolism of orally administered histamine in sheep.


Some observations on the pharmacology of mitragynine.


Dialytrode for long term intracerebral perfusion in awake monkeys.


Scanning electron microscopy of hydrophilic contact lenses.


Pathologic anatomy of the His-Tawara system and electrocardiographic abnormalities in chronic Chagas' heart disease.


Species difference between Old World and New World monkeys in the organization of the striate-prestriate association.


Close correlation between changing content of specific amino acids in epileptogenic cortex of cats, and severity of epilepsy.


Evidence for spinal cord unit activity responsive to peripheral warming in the primate.


Quantitative analyses of behavioral sequences elicited by automated telestimulation in squirrel monkeys.


Induction of reproductive phage in B. subtilis by triethylene-melamine or methyl-nitro-nitrosoguanidine and their reaction with deoxyribonucleic acid.


Extrageniculostriate vision in the monkey. 3. Circle VS triangle and "red VS green" discrimination.


Limbic lesions and the problem of stimulus--reinforcement associations.


Multiple lower esophageal diverticula: unusual endoscopic appearance.


Perhexiline maleate in angina pectoris. A controlled, double-blind clinical trial.


Hemoglobin, hematocrit, leukocyte count, and blood grouping in older people.


The filtration coefficient of the blood-aqueous barrier.


Salicylate poisoning in the elderly: diagnostic pitfalls.


An ergot alkaloid preparation (hydergine) versus placebo for treatment of symptoms of cerebrovascular insufficiency: double-blind study.


Ribosomal ribonucleic acid synthesis and maturation in the blue-green alga Anacystis nidulans. Methods are described for preparation of pulse-labeled ribonucleic acid (RNA) from the blue-green alga Anacystis nidulans. Synthesis of labeled RNA was found to be in part dependent on concurrent photosynthesis and was inhibited by the antibiotic streptolydigin. Mature 23S ribosomal RNA (rRNA) appeared before mature 16S rRNA. Formation of either molecule was inhibited by chloramphenicol, and RNA species of lesser mobility accumulated. These species may be precursors of the mature forms. Maturation of 16S rRNA was also inhibited by streptolydigin. (The effect of this antibiotic on 23S rRNA maturation was not examined). In many respects, ribosomal RNA synthesis and maturation in this blue-green alga appear to follow the pattern already established for bacteria.


Role of iron and sulfur in pigment and slime formation by Pseudomonas aeruginosa. Media and an analytical scheme have been developed which allow both a qualitative and quantitative estimation of the formation of pyocyanine, related phenazines, pyorubrin, and a blue and a yellow-green fluorescent pigment by Pseudomonas aeruginosa. Use of the defined pyocyanine medium of Frank and DeMoss with sulfate or various organic sulfur sources allowed formation of pyocyanine, related phenazines, and pyorubrin. When sulfite was the sulfur source with or without iron, P. aeruginosa formed either a yellow-green or a blue fluorescent pigment. Formation of fluorescent pigments of P. aeruginosa is related to the ability of sulfite to act as a specific sulfur source. In an investigation of the role of both added iron and sulfur sources, complex patterns of pigment formation were observed. In addition to the fluorescent pigments, sulfite also supported the formation of slime by P. aeruginosa.


Spore pool glutamic acid as a metabolite in germination. Spore glutamic acid pools were examined in dormant and germinating spores using colorimetric and (14)C analytical procedures. Germination of spores of Bacillus megaterium (parent strain), initiated by d-glucose, was accompanied by a rapid drop in the level of spore pool glutamate, from 12.0 mug/mg of dry spores to 7.7 mug/mg of dry spores after 30 sec of germination. Similar decreases in extractable spore pool glutamate were observed with l-alanine-initiated germination of B. licheniformis spores. On the other hand, glutamate pools of mutant spores of B. megaterium, with a requirement of gamma-aminobutyric acid for spore germination, remained unchanged for 9 min of germination, at which time more than 50% of the spore population had germinated. Evidence for conversion of spore pool glutamate to gamma-aminobutyric acid during germination of spores of B. megaterium (parent strain) was obtained.


Similarity in the size and number of ribosomal proteins from different prokaryotes. The ribosomal proteins from nine species of prokaryotes have been compared by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The stained gels were scanned spectrophotometrically, the weight and number average molecular weights were calculated, and the detailed distribution of the proteins as a function of molecular weight was determined. By all of these criteria, the ribosomal proteins from all the species closely resembled each other, despite differences in the pattern of protein bands by conventional disc-gel electrophoresis. Therefore, it is suggested that the structural requirements for the assembly of ribosomal subunits have imposed limitations on the evolution of the ribosomal proteins and that their size has been highly conserved.


Fate of transforming deoxyribonucleic acid after uptake by competent Bacillus subtilis: size and distribution of the integrated donor segments. A series of sheared donor-recipient complex samples were prepared from a competent Bacillus subtilis culture which had been transformed by using (3)H, (2)H-labeled deoxyribonucleic acid. Measurement of the molecular weights and buoyant densities of these samples led to the following conclusions. (i) The average size of the single-stranded donor segment which is integrated is 2.8 x 10(6). (ii) These donor segments are not randomly distributed in the recipient genome, but are clustered in groups, each group containing several discrete donor segments.


Effects of fatty acids on growth and envelope proteins of Bacillus subtilis. Fatty acids of different chain lengths were added to cultures of Bacillus subtilis growing in nutrient sporulation medium, and the effects of these fatty acids on growth, oxygen uptake, adenosine triphosphate (ATP) concentration, and membrane protein composition were examined. All fatty acids inhibited growth, the effect being reduced in the presence of glycolytic compounds and reversed by transfer to medium without fatty acids. The inhibition of growth was correlated with a reduction in both the rate of oxygen consumption and the concentration of ATP per cell. The concentration required to obtain a certain degree of inhibition increased with decreasing molecular weight of the fatty acid. However, the reduced nicotinamide adenine dinucleotide oxidation system of cell envelope preparations (i.e., the electron transport system) was not inhibited. Submaximal growth inhibition was accompanied by the relative increase of a membrane protein band revealed by urea-acetic acid gel electrophoresis. This increase was blocked by actinomycin or chloramphenicol. All of the above changes could also be produced by 2,4-dinitrophenol. The inhibition results are best explained by assuming that the fatty acids reversibly react with the cell membrane or proteins in it; they could either alter the membrane structure or uncouple the electron transport chain from two types of proteins, those used for ATP regeneration and others needed for the transport of certain compounds into the cells.


Minimal requirements for commitment to sporulation in Bacillus megaterium. Commitment to sporulation was examined by means of both endotrophic sporulation and rejuvenation experiments. In both cases, a point of commitment to the completion of sporulation occurred at stage II. With 2 x 10(8) cells/ml, the process by which commitment occurred required 0.5 mm Mg(2+), 10.0 mm phosphate, and an energy source (minimum of 5.0 mm acetate). For completion of sporulation and formation of normal, heat-resistant refractile spores, 0.3 mm Ca(2+) was required. Except for this Ca(2+) requirement, the completion of sporulation after commitment was independent of the nature of the surrounding medium. Some aspects of the utilization of these required substances were examined.


Mode of action of phleomycin on Bacillus subtilis. Phleomycin appears to act on the cell wall and membrane to induce the release of membrane-associated deoxyribonucleic acid (DNA) and the degradation of the DNA. Degradation occurs in a series of energy-requiring endonuclease and exonuclease reactions. These produce, first, single-strand breaks, then double-strand breaks, and finally almost complete solubilization of the cellular DNA. The in vivo inhibition of DNA synthesis by phleomycin is probably a secondary effect caused by the destruction of template DNA.


A second transport system for L-arabinose in Escherichia coli B-r controlled by the araC gene. Escherichia coli B/r possesses two active transport systems for l-arabinose, both of which are regulated by araC, the regulatory gene for the l-arabinose operon. The system with the higher affinity for l-arabinose has a K(m) for initial uptake of l-arabinose of 8.3 x 10(-6)m; the system of lower affinity has a K(m) of 1.0 x 10(-4)m. The two systems can also be distinguished by differences in their response to analogues that act as competitive inhibitors of initial uptake. d-Galactose strongly inhibits l-arabinose uptake by the high affinity system but only weakly inhibits such uptake by the low affinity system. d-Fucose, d-xylose, and beta-methyl-l-arabinoside competitively inhibit the uptake of l-arabinose by both systems to approximately the same extent. d-Glucose and l-lyxose do not inhibit either system. On the basis of kinetic evidence and the properties of mutants lacking one or the other of the two systems, it has been concluded that the high affinity uptake system involves the l-arabinose binding protein. Kinetic studies have shown that the K(m) for l-arabinose uptake by the high affinity system resembles the K(m) for binding of l-arabinose by the binding protein, and both have similar K(i) values for the inhibitory substrates tested. A consideration of l-arabinose transport-deficient mutants has demonstrated that the previously described araE mutants lack the low affinity system but retain the high affinity system and have normal levels of the l-arabinose binding protein. Mutants described in this communication which lack only the high affinity system either contain no detectable l-arabinose binding protein or possess an immunologically cross-reacting material that is reduced in its ability to bind l-arabinose. These observations support a role for the binding protein in l-arabinose uptake.


Appearance of muramic lactam during cortex synthesis in sporulating cultures of Bacillus cereus and Bacillus megaterium. Evidence is presented for the appearance of muramic lactam during the late stages of sporulation at about the same time dipicolinic acid synthesis occurs.


Effect of thiotepa on ribosomal protein of house fly eggs.


Superoxide dismutase in Bacillus popilliae. Vegetative cells of Bacillus popilliae were devoid of catalase but had high levels of superoxide dismutase. This provides further support of a theory that oxygen tolerance by an organism is more dependent on superoxide dismutase than on catalase.


Human immunity to Pseudomonas aeruginosa. I. In-vitro interaction of bacteria, polymorphonuclear leukocytes, and serum factors.


Human immunity to Pseudomonas aeruginosa. II. Relationship between heat-stable opsonins and type-specific lipopolysaccharides.


A rapid method for demonstration of precipitating antibody against influenza virus by counterimmunoelectrophoresis.


A world look at the venereal diseases: recrudescence of the venereal diseases. Factors affecting the increased incidence of the venereal diseases syphilis and gonorrhea throughout the world since World War 2 are considered.  Both diseases declined after the war to a minimum in about 1957, but they have since increased, particularly gonorrhea to even higher incidence in many countries.  Late and congenital syphilis, however, have declined almost universally.  Factors invoked to explain the recrudescence include decreased virulence of both organisms, perhaps aided by better nutrition and hygiene.  An important trend is antibiotic resistance.  Sulfonamide resistance was noted during World War 2.  A relative penicillin resistence, threatening the convinient use of cheap single-dose treatment, is particularly frequent in the Far East.  Other antibiotics and penicillin-probeneoid combinations are still available and have contributed to improved cure rates in some countries, e.g., Canada, United Kingdom, Denmark, Greenland and Norway.  Environmental fa ctors suggested are more susceptible persons, greater population mobility, promiscuity, use of pills and IUDs instead of condoms, and changed sexual practices resulting in rectal and oral infections.  Hopes for control in the future include formation of adequate case finding organizations in more places, health education, modification of behavior, discovery of a serologic test for gonnorrhea, and although unlikely, immunization.  The author concluded that the problems of venereal disease will probably increase: even if syphilis and gonorrhea were controlled, the other sexually transmitted entities (spirochetes, bacteria, virus, protozoa, fungi, parasites and possible  cervical carcinoma) will pose problems.


Serodiagnosis of syphilis.

Serodiagnosis of syphilis.


Asymptomatic gonorrhea.

Asymptomatic gonorrhea.


Ankle fractures.

Ankle fractures.


Chromosomal interchange in mature oocytes of Drosophila.


The cytogenetics of mutator gene-induced X-linked lethals in Drosophila melanogaster.


The effects of treating Drosophila females with actinomycin-D on the yields of dominant lethals, translocations and recessive lethals recovered from X-irradiated spermatozoa.


The mechanism of immunostimulation induced by inactivated Brucella abortus.


Insulinotropic action of a new sulfonylurea: gliclazide.


Nutritional anaemias. Report of a WHO group of experts.


Ocular anomalies in de Lange syndrome.

Ocular anomalies in de Lange syndrome.


Racemose (cirsoid) hemangioma in rhesus monkey retina.


Crystalglobulinemia.

Crystalglobulinemia.