Micropuncture studies of sodium transport in the remnant kidney of the dog. The effect of graded volume expansion. Proximal and distal tubule micropuncture studies were performed to examine the response to graded extracellular volume (ECV) expansion in 10 normal dogs (stage I), 11 dogs with a unilateral remnant kidney (stage II), and 7 dogs with a remnant kidney after removal of the contralateral kidney (stage III). Before ECV expansion in stage III, there was a suggestive reduction in proximal tubule as well as loop fractional reabsorption of sodium. After ECV expansion to 3% body weight proximal tubule reabsorption was depressed in all groups of animals, while little further inhibition was observed in this segment with additional expansion to 10% body weight. In contrast, the fraction of filtered sodium remaining in the distal tubule rose progressively in all three groups after graded ECV expansion, suggesting that the graded natriuretic response found in the final urine was largely due to a similar response in the loop of Henle rather than that in the proximal tubule. The distal tubule response of the remnant kidney in both stages II and III was greater than that in stage I. These data indicate that although enhanced sodium excretion per nephron in chronic renal failure may be related to uremia, its exaggerated response to ECV expansion is due, at least in part, to certain as yet unidentified intrarenal factors consequent to reduction in functioning renal mass.


Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. The details of a radioimmunoassay capable of measuring as 5 pg of prostaglandin A, E, and F (PGA, PGE, and PGF) in human and rat plasma are described. Plasma samples are extracted (with 4000 cpm [(3)H] PGE(1) added for calculation of recovery) with an organic solvent system at an apparent pH of 5.8 and then chromatographed on silicic acid columns with increasing concentrations of methanol to separate PGA, PGE, and PGF. Each chromatographed sample is measured by radioimmunoassay, using the homologous antibody and tritiated marker. 40 normal individuals had mean plasma concentrations of PGA, PGE, and PGF of 1062+/-107 pg/ml, 385+/-30 pg/ml, and 141+/-15 pg/ml, respectively. Elevated PGE levels were measured in the plasma of patients with medullary carcinoma of the thyroid, carcinoid, and neuroblastoma. Treatment of rats with indomethacin decreased serum PGE levels by 67%. The radioimmunoassay appears to be of considerable experimental as well as clinical interest.


Alterations in distribution of blood flow to the lung's diffusion surfaces during exercise. We measured simultaneously, by single breath methods, pulmonary capillary blood flow (Q(c)), carbon monoxide diffusing capacity (DL(CO)), and isotopic oxygen ((18)O(18)O) diffusing capacity (DL(18) (O2)) in five normal males during conditions of rest and moderate exercise at mixed venous O(2) tensions (PO(2) 33-44 mm Hg). During moderate exercise at a work load of 100 W. pulmonary capillary blood flow increased from 6.9+/-1.5 to 12.9+/-3.4 min(-1) and DL(18) (O2) increased from 25+/-4 to 43+/-3 ml.min(-1).mm Hg(-1), whereas DL(CO) showed no significant change (45+/-5 to 49+/-10 ml.min(-1).mm Hg(-1)). DL(18) (O2) increased proportionally to Q(c) (r = 0.74), where DL(CO) did not (r = 0.08). The greater increase in DL(18) (O2) during exercise can be explained by a more homogeneous diffusion/perfusion (DL(O2)/Q(c)) distribution in the individual respiratory exchange units during exercise. This improved distribution of DL(O2)/Q(c) acts to help prevent an increase in alveolar-arterial O(2) tension difference from developing despite the decrease in pulmonary erythrocyte transit times that occur during exercise. The insignificant rise in DL(CO) with exercise under these hypoxic breathholding conditions may result from pulmonary vasomotor responses to short-term hypoxia or from relative insensitivity of DL(CO) to moderate levels of exercise.


Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia. The blood in sickle cell anemia has a very low oxygen affinity and, although 2,3-diphosphoglycerate (2,3-DPG) is increased, there is doubt as to whether this is the only factor responsible. In this study of 15 patients with sickle cell anemia (Hb SS) no correlation was found between oxygen affinity (P(50) at pH 7.13) and 2,3-DPG in fresh venous blood. Whole populations of Hb SS erythrocytes were therefore separated, by an ultracentrifuge technique, into fractions of varying density. The packed red cell column was divided into three fractions; a bottom fraction rich in deformed cells or irreversibly sickled cells (ISC), with a very high mean corpuscular hemoglobin concentration (MCHC); a middle fraction containing cells with the highest content of fetal hemoglobin; and a top fraction containing reticulocytes and discoid cells but free of deformed cells. Oxygen affinity was shifted to the right in all layers (mean P(50) (pH 7.13)+/-1SD: top 46.3+/-2.9 mm Hg: middle 49.8+/-4.9 mm Hg; bottom 61.0+/-5.8 mm Hg) compared with normal blood (top 32.1+/-0.7 mm Hg: bottom 30.1+/-0.5 mm Hg). 2.3-DPG was increased in the top fraction, but was low or normal in the bottom fraction (top 21.8+/-3.4 mumol/g Hb: middle 17.7+/-2.2 mumol/g Hb; bottom 13.8+/-3.1 mumol/g Hb; normal whole blood 14.3+/-1.2 mumol/g Hb). The level of 2,3-DPG in top fractions could not account for the degree of right shift of P(50), and in the middle and bottom fractions the even greater right shifts were associated with lower levels of 2,3-DPG. Top fraction cells depleted of 2,3-DPG had a higher, but still abnormally low, oxygen affinity. A strong relationship was found between oxygen affinity and MCHC. The fractions with the greatest right shift in P(50) had the highest MCHC (top 32.4+/-2.0; middle 36.2+/-3.1; bottom 44.6+/-3.2 g/100 ml, respectively) and the plot of P(50) vs. MCHC showed a positive correlation (r = 0.90, P < 0.001). The red cell population in sickle cell anemia is not homogeneous but contains cells of widely varying Hb F content, 2,3-DPG, and hemoglobin concentration. Paradoxically, the cells with the lowest O(2) affinity have the lowest 2,3-DPG, but they also have the highest concentration of Hb S. The dense, deformed cell called the ISC is but the end stage in a process of membrane loss and consequent increase in hemoglobin concentration. The P(50) of Hb SS blood is, to a large extent, determined by the presence of these cells (r = 0.85, P < 0.001). Increased concentration of Hb S in the cell favors deoxygenation and crystallization even at relatively high P(o2). Lowered affinity for oxygen appears to be closely associated with Hb S concentration and not with 2,3-DPG content.


Cellular accumulation of L-cystine in rat kidney cortex in vivo. Cellular accumulation of L-cystine in rat kidney cortex in vivo has been studied using L-[(35)S]cystine. The L-[(35)S]cystine radioactivity in plasma decreases to less than 10% of the initially calculated value by 15 min. Four (35)S-containing intracellular products of L-cystine metabolism were identified including cystine, cysteine, reduced glutathione, and an as yet unidentified compound. The latter is probably taurine, cysteinesulphinate, or cysteic acid. Cellular accumulation of these products was found to be more rapid in vivo than in vitro. Cellular accumulation of the products of L-cystine metabolism was found to be essentially unchanged in the presence of ureter ligation. Unlabeled L-lysine administered simultaneously with L-[(35)S]cystine, in both the presence and absence or ureter ligation, enhanced the cellular accumulation of intracellular metabolic products of L-[(35)S]cystine. Simultaneous (35)S cellular accumulation and L-cystine clearance studies were performed both in the presence and absence of L-lysine. L-Lysine enhanced cellular accumulation of (35)S-products despite an accompanying increase in L-cystine clearance. The results are interpreted as evidence for a dissociation between cellular accumulation and transepithelial transport. This evidence for independent luminal transport and peritubular cellular accumulation could explain the apparent paradox in the disease cystinuria where there appears to be a luminal transport defect for L-cystine, but no defect for cellular accumulation of L-cystine metabolic products in vitro.


Metabolism of steroid and amino acid moieties of conjugated bile acids in man. 3. Cholyltaurine (taurocholic acid). After oral administration of [2,4-(3)H]-cholyl[(35)S]taurine to eight healthy subjects with indwelling nasoduodenal tubes, the specific activity of the cholyl and taurine moieties and the distribution of radioactivity in biliary bile acid and urinary metabolites, as well as total urinary and fecal (35)S and (3)H, were measured at intervals for 4-8 days. Similar measurements were made after [(35)S]taurine was given orally or intravenously or instilled into the distal intestine. The daily fractional turnover rate of the taurine moiety of cholyltaurine was low and similar to that of the cholyl moiety, indicating that deconjugation occurring during enterohepatic cycling was less than half that previously observed for glycine-conjugated bile acids. Some of the cholyl moiety was absorbed but, since reconjugation occurred predominantly with glycine, little reincorporation into the cholyltaurine pool was observed. Some of the taurine moiety was also absorbed intact but entered large taurine pools, and little reincorporation into the cholyltaurine pool was seen. Oral administration of taurine expanded the cholyltaurine pool and induced a decrease in the fractional turnover rate of the cholyl moiety of cholyltaurine, interpreted to indicate a greater reincorporation of the cholyl moiety because of increased reconjugation with taurine. Taurine moiety not absorbed as taurine appeared to be absorbed largely as sulfate which, like taurine, entered large endogenous pools. Little fecal excretion of (35)S occurred. (35)S was excreted in urine as taurine and sulfate, and excretion in the first 24 h (as percentage of administered dose) correlated highly (r = 0.93) with the daily fractional turnover rate of the taurine moiety. When taurine was instilled into the distal intestine, it appeared as such in plasma, but the more distal the site of instillation, the greater the fraction of urinary (35)S present as sulfate. The [(35)S]sulfate appeared to have come from bacterial degradation of [(35)S]taurine because, when [(35)S]taurine was given intravenously, (35)S was excreted in urine chiefly as [(35)S]taurine with little SO(4)=(-)[(35)S] being present.


Mechanism of effect of prostaglandin E 1  on renal water excretion. The present study examined the effect of prostaglandin E(1) (PGE(1)) on renal water excretion in the anesthetized dog. Renal perfusion pressure was kept constant by adjustment of a suprarenal aortic clamp. In seven experiments the intravenous administration of PGE(1) (7 mug/min) significantly increased urinary osmolality from 76 to 381 mosmol (P < 0.001) and decreased free water clearance from 2.2 to - 0.02 ml/min (P < 0.001). These effects promptly were reversed with cessation of the infusion. This antidiuretic effect occurred both in innervated and denervated kidneys and was not associated with changes in glomerular filtration rate, renal vascular resistance, or solute excretion rate. In 10 experiments in hypophysectomized dogs no effect of intravenous PGE(1) on free water clearance and urinary osmolality was observed. The intrarenal administration of PGE(1) (1 mug/min) to six water-loaded and two hypophysectomized dogs caused no systemic vascular changes and increased rather than decreased free water clearance (2.83 to 4.08 ml/min, P < 0.001). No significant change in urinary osmolality occurred. Glomerular filtration rate was not altered by the intrarenal infusion, but reversible changes in solute excretion rate and renal vascular resistance occurred. These results thus indicate that the antidiuresis associated with intravenous PGE(1) is mediated primarily by the release of vasopressin rather than alterations in renal hemodynamics or solute excretion. The diuretic effect of intrarenal PGE(1) occurs in the absence of vasopressin and is most likely mediated primarily by increased distal delivery of tubular fluid to the diluting segment of the nephron rather than changes in water permeability of the renal tubular epithelium.


Altered lipid metabolism in human platelets after primary aggregation. Thrombin and poly-l-lysine alter the incorporation of acetate, glycerol, and fatty acids into the lipids of washed human platelets. Both aggregating agents decrease the incorporation of acetate into all lipid classes other than free fatty acids. Similarly, glycerol incorporation into complex lipids is impaired by both thrombin and polylysine. Thrombin caused marked depression of the incorporation of palmitic acid into both lecithin and triglycerides. By contrast it enhanced the incorporation of oleic acid into lecithin, but not into triglycerides. The data suggest that the process of primary platelet aggregation is associated with a defect in the assembly of complex lipids.


Mechanism of effect of alpha adrenergic stimulation with norepinephrine on renal water excretion. The present study was undertaken to investigate the mechanism whereby alpha adrenergic stimulation with intravenous norepinephrine results in a water diuresis. Renal perfusion pressure was kept constant in all experiments by adjustment of a suprarenal aortic clamp. In hydropenic anesthetized dogs the intravenous infusion of norepinephrine (0.5 mug/kg per min) was associated with a mean decrease in urinary osmolality from 616 to 126 mosmol/kg (P < 0.001) which increased to 532 mosmol/kg (P < 0.001) after the infusion was discontinued. During the same period of time the mean free water clearance increased from -0.437 to 1.59 (P < 0.001) and then returned to -0.314 ml/min (P < 0.001) after cessation of the infusion. This diuretic effect occurred in both innervated and denervated kidneys and was not associated with an increase in glomerular filtration rate or solute excretion. Systemic arterial pressure increased from 121 to 142 mm Hg during the norepinephrine infusion. Studies were also performed in hypophysectomized animals receiving a constant infusion of either 80 mug/kg per min or 20-40 muU/kg per min of vasopressin. In these animals, intravenous norepinephrine was not associated with changes in either urinary osmolality or free water clearance. The intrarenal administration of norepinephrine, in doses comparable with those reaching the kidneys during the intravenous studies, also resulted in no significant change in either urinary osmolality or free water clearance in hypophysectomized animals receiving 20-30 muU/kg per min of vasopressin. These results thus indicate that the water diuresis associated with intravenous norepinephrine is mediated primarily by suppression of vasopressin release rather than by changes in renal hemodynamics, renal innervation, or an effect of norepinephrine on the water permeability of the tubular epithelium.


Deficiency of the chemotactic factor inactivator in human sera with   1 -antitrypsin deficiency. As revealed by appropriate fractionation procedures, human serum deficient in alpha(1)-antitrypsin (alpha(1)-AT) is also deficient in the naturally occurring chemotactic factor inactivator. These serum donors had severe pulmonary emphysema. Serum from patients with clinically similar pulmonary disease, but with presence of alpha(1)-AT in the serum, showed no such deficiency of the chemotactic factor inactivator. When normal human serum and alpha(1)-AT-deficient human sera are chemotactically activated by incubation with immune precipitates, substantially more chemotactic activity is generated in alpha(1)-AT-deficient serum. These data indicate that in alpha(1)-AT-deficient serum there is an imbalance in the generation and control of chemotactic factors. It is suggested that the theory regarding development of pulmonary emphysema in patients lacking the alpha(1)-antitrypsin in their serum should be modified to take into account a deficiency of the chemotactic factor inactivator.


Myelin from human peripheral nerves. Quantitative and qualitative studies in two age groups. Myelin in femoral nerve segments obtained at autopsy was isolated quantitatively by a series of discontinuous and continuous flotation procedures. The total amount of myelin isolated from these nerves was expressed as the sum of cholesterol, glycolipid, phospholipid, and protein and averaged 2.6+/-0.4 mg/g in a group aged 60-77 yr compared with 10.8+/-1.9 mg/g of nerve in a group aged 35-58 yr. The lower value in the older group remained apparent whether the myelin content was related to the whole nerve segment, its unit length or weight. This indicates that the decrease is an absolute one, not related to a change with aging in the nonmyelin content of nerve. No qualitative differences in myelin lipids were found between the two groups. Protein content was, however, significantly higher in the older group (34 and 28.7% of the total myelin weight, respectively). The decrease in myelin content with aging, observed by direct measurement in this study, may be the structural counterpart to age related alterations in peripheral nerve function-decreased conduction velocity, and impaired appreciation of vibration.


Discoid menisci.

Discoid menisci.


Facial pain: a neurological perspective.


Control of thyroid hormone secretion in normal subjects receiving iodides. The administration of exogenous iodides (saturated solution of potassium iodide, SSKI) to normal male volunteers resulted in a significant decrease in the serum concentration of thyroxine (T(4)) and triiodothyronine (T(3)) and a significant increase in serum concentration of thyrotropin (TSH). During the control period (phase I), serum concentrations of T(4) averaged 6.9+/-1.8 mug/100 ml (mean +/-SD), T(3) 106+/-15 ng/100 ml, and TSH 3.7+/-1.3 muU/ml. During the administration of 1 drop of SSKI twice daily for 11 days (phase II), there was a small but significant decrease in the serum concentration of T(4) and T(3) (5.8+/-1.6 mug/100 ml and 91+/-19 ng/100 ml, respectively) and a small but significant increase in the serum concentration of TSH (6.0+/-3.5 muU/ml). During the administration of 5 drops of SSKI twice daily (phase III) over the following 12-19 days, these changes persisted, except for a small increase in the serum concentration of T(3) (97+/-20 ng/100 ml), which was statistically significant when compared to values obtained during phase II. Values returned to control levels 14 days after withdrawal of SSKI. Almost all these observed changes took place within the limits of the normal range. It is postulated that, in euthyroid individuals, iodides specifically inhibit release of T(4) and probably of T(3). The resulting slight decrease in values for serum T(4) and T(3) elicits a small increase in TSH secretion which, it is postulated, antagonizes the inhibition of hormone release induced by iodides. As a result, a new equilibrium is reached which maintains the euthyroid state.


Prenatal mortality in Iowa, 1963.

Prenatal mortality in Iowa, 1963.


Too much business mindedness?

Too much business mindedness?


On musculoskeletal tumors.

On musculoskeletal tumors.


Radiology window: case no. 9.

Radiology window: case no. 9.


Minority students for medicine and the hazards of high school.


The regionalization of academic medicine: the metamorphosis of a concept.


Human values and medical education from the perspectives of health care delivery.


Undergraduate education in family medicine.


A view of the comprehensive role of the basic sciences in medical education.


The validity of Patient Management Problems.


The academic medical center and the Regional Medical Program.


A comparison of persistent high and low achievers through four years of undergraduate medical training.


Graduate education: once for the exceptional, now essential for all.


Woman students in U.S. medical schools: past and present trends.


In defense of lecturing.

In defense of lecturing.


Psychiatric residents versus team approach in community psychiatry.


Introduction to the scanning electron microscope for the clinician-researcher.


Cystic hygroma of the neck.

Cystic hygroma of the neck.


Vocal cord paralysis following approaches to the anterior cervical spine.


Transmedian innervation of the human upper lip: an embryological study.


The management of mandibular fractures in edentulous patients by intramedullary pinning.


Disseminated coccidioidomycosis presenting as facial granulomas in pregnancy: a report of two cases and a review of the literature.


The identification and protection of the laryngeal motor nerves during thyroid and laryngeal surgery: a new microsurgical technique.


The inner ear fluids in man.

The inner ear fluids in man.


The continuing evolution of health maintenance organizations.


Bile-salt metabolism in the newborn. Measurement of pool size and synthesis by stable isotope technic.


Constitutionality of exemption laws on guarantee of purity for blood transfusions and tissue and organ transplants.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 9-1973.


Getting the lead out.

Getting the lead out.


Respiratory stimulants and obstructed airways.


"English flu"--a primer.

"English flu"--a primer.


Viral hepatitis.

Viral hepatitis.


Other tumors complicating Hodgkin's disease.


Arrhythmias in respiratory failure.

Arrhythmias in respiratory failure.


Does interstitial lung edema cause changes in lung compliance?


Vitamin D metabolism.

Vitamin D metabolism.


Right and left on health care.

Right and left on health care.


Regional variations in surgical practice.


Advantages of prohibition.

Advantages of prohibition.


Personally fabricated chin implants.

Personally fabricated chin implants.


The extensor indicis proprius syndrome. A clinical test.


Vertical abdominoplasty.

Vertical abdominoplasty.


Late reconstruction of the lax oral sphincter in facial paralysis.


Expanding hematoma after rhytidectomy. A retrospective study.


Treatment of the chronic, painful metatarsal callus by a tendon transfer.


Patients' refusal of surgery after innovar premedication.


A new anatomical concept of postoperative complications in esthetic rhinoplasty.


Alterations in finger growth following flexor tendon injuries. A clinical and laboratory study.


Areolar sharing to reconstruct the absent nipple.


The efficacy of local steroid injection in the treatment of stenosing tenovaginitis.


Regeneration of the cartilaginous nasal septum in the rat, after resection. Its influence on facial growth.


Plantar warts, plantar calluses, and such.


The pitfall of surgical excision of vaccination scars in the deltoid area.


Maxillary recession for bucktooth deformity. Case report.


Soft silicone bag for antral inflation.

Soft silicone bag for antral inflation.


Dynamic splinting for dorsal burns of the hand.


Modification of hyperkinetic behavior by nortriptyline.


Management of acute sore throat.

Management of acute sore throat.


Radioisotopic brain scanning.

Radioisotopic brain scanning.


Cleidocranial dysostosis.

Cleidocranial dysostosis.


Sample review.

Sample review.


Rehabilitation of the ostomate.

Rehabilitation of the ostomate.


Services of the consolidated laboratories available to physicians.


Nephrocalcinosis and hypertension in juvenile primary hyperparathyroidism.


Diencephalic syndrome. Long-term survival.


"Cgs" and a new editor.

"Cgs" and a new editor.


Sweating responses of neonates to local thermal stimulation.


Congenital dislocation of the hip in the newborn.


Combined measles-rubella vaccines. Virus dose and serologic response.


Altered peripheral nerve conduction velocity. Chronic lead intoxication in children.


Peutz-Jeghers syndrome.

Peutz-Jeghers syndrome.


Congenital intraluminal mucosal web of the esophagus with tracheo-esophageal fistula.


Cerebrospinal fluid imaging as a method to evaluate communicating hydrocephalus in dogs.


Measurements of phases of left ventricular systole in the awake dog by use of carotid loop.


Protective immunity against Ancylostoma caninum in dogs vaccinated with free-living soil nematodes.


Cellular and whole-culture bivalent leptospiral bacterins: safety and potency in guinea pigs and hamsters.


Evaluation of a polyvalent leptospiral bacterin: safety in guinea pigs and potency in hamsters.


Failure to immunize swine against streptococcic lymphadenitis with autogenous bacterins.


Measurement of nitrite and nitrate in blood.


Nature of white heifer disease (partial genital aplasia) and its mode of inheritance.


Clofazimine treatment of cows naturally infected with Mycobacterium paratuberculosis.


Dichlorvos gel formulation as an equine anthelmintic.


Structure of synovial membrane of sheep.


Pathogenicity of experimentally induced concurrent infections of Fasciola hepatica and Haemonchus contortus in sheep.


Experimentally induced iodide toxicosis in lambs.


Development of the bovine eye.

Development of the bovine eye.


Incidence of antibody to swine influenza virus in Iowa breeder and butcher pigs correlated with signs of influenza-like illness.


Epidermal cell renewal in the dog.

Epidermal cell renewal in the dog.


The rapid processing of canine blood gas tension and pH measurements.


The appearance of exo- -mannosidase in cultures of Penicillium charlesii.


Radioimmunoassay.

Radioimmunoassay.


Counting of beta and gamma emitters used in clincal radioimmunoassays and competitive-binding assays by liquid scintillation counters.


Australia antigen content of commercial quality-control sera.


Evaluation of a glucose oxidase-peroxidase method adapted to the single-channel autoanalyzer and SMA 12-60.


Nonspecific interferences in the fluorometric determination of plasma cortisol.


Enzyme standardization in clinical enzymology.


Modified radioimmunoassay of urinary aldosterone.


Creatine kinase: ATP contaminating creatine phosphate substrate of a commercial kit.


Radioassay of serum folate: some criticisms.


Modified sickle cell anemia screening procedure.


An investigation of phosphorylcholine and phosphorylethanolamine metabolism in the skin and other tissues of the guinea pig, Cavia porcellus.


Eggshell pigments of the Araucano fowl.

Eggshell pigments of the Araucano fowl.


Chicken red blood cell adenylate deaminase: purification and comparison with the enzymes from chicken brain and muscle.


Two types of pyruvate kinase in schistosomes and filariae.


The susceptibility of bovine, canine and ovine  -crystallins to gamma-irradiation.


The carbohydrate composition of invertebrate hemagglutinin subunits isolated from the lobster Panulirus argus and the oyster Crassostrea virginica.


Stability to freezing of steroid binding proteins in fish plasma.


Thermal modulation of pyruvate metabolism in the fish Gillichthys mirabilis: the role of lactate dehydrogenases.


Rodent cardiac and skeletal muscle adenylate kinase isozymes.


In vitro fatty acid oxidation in liver and heart from neonatal swine (Sus domesticus).


Partifation and comparative biochemistry of a protease from the starfish Pisastes giganteus.


Multiple immunoglobulin classes among sharks and their evolution.


Ornithine as a precursor of collagen proline and hydroxyproline in the chick embryo (Gallus gallus).


Snake venom toxins. Structure-function relationships and phylogenetics.


Metabolic responses of the fresh-water bivalve, Pleurobema coccineum (Conrad), to anerobic conditions.


Genetic variation of mitochondrial aspartate aminotransferase in the teleost Cyprinodon nevadensis.


Dehydrogenases and nucleic acids in rat mammary gland during involution initiated at various stages of lactation.


Recognition and management of shock in pediatric patients.


Cryoextraction of cataracts in high myopes.


Common cutaneous disorders of the eyelids.


Psychological aspects of the diagnosis of deafness in a child.


Acute epiglottis with Ludwig's angina.

Acute epiglottis with Ludwig's angina.


The noise pollution crisis. 1. The problem.


The duty of possessing necessary training and knowledge.


Enzyme histochemistry and hormones of the developing gastrointestinal tract of the chick embryo. V. The ultrastructural and biochemical evidence for the presence of an insulin like substance, enteroglucagon and serotonin in the developing chick duodenum.


Metabolic variants of intestinal alkaline phosphatase in relation to fat absorption: in situ demonstration with the organ-specific inhibitors L-phenylalanine and L-homoarginine.


[Relationship between l-asparaginase activity and the oncogenic power of different Agrobacterium tumefaciens mutants (Smith and Town.) Conn].


Monoclonal IgA and IgM in the serum of a single patient (SC). II. Identity of light chains from IgA(k) and IgM(k).


Alteration of macrophage interfacial tension by supernatants of antigen-activated lymphocyte cultures.


Blocking of the hemolytic expression of the classical complement sequence by products of complement activation via the alternate pathway. Materials responsible for the blocking phenomenon and their proposed mechanism of action.


Reactions fo murine lymphoma cells with infectious mononucleosis sera.


Studies of complement-mediated membrane damage: the influence of erythrocyte storage on susceptibility to cytolysis.


Migration inhibitory effect of cell-free supernatants from tuberculin-stimulated cultures of human mononuclear leukocytes demonstrated by two-step MIF agarose assay.


Fibrosarcoma induction in immunosuppressed mice.


Origin and differentiation of cardiac muscle cells in the mouse.


Gastrointestinal manifestations of chronic granulomatous disease.


The "anemia" of childhood: evidence for a physiologic response to hyperphosphatemia.


Shock-induced optic neuropathy: a cause of nonprogressive glaucoma.


Simplified diagnosis of small-airway obstruction.


Medical draft resistance: a Washington, D.C., experience.


Disabled children--free contraception for all? More liberal liquor laws? The history of thalidomide has risen many moral issues which have come to the foreground once more.  Presently they are being debated in the British Parliament.  No satisfactory financial arangement has been made for the children who have been born defective because their mothers had taken thalidomide during pregnancy.  The Secreatary of State for the Department of Health and Social Security asserted that there is no legal liability on the part of the government and no implication about a drug since it had been prescribed under the National Health Service.  The government, however, decided to make 3 million pounds available for defective children be it a result of thalidomide or some other drug.  The special case of the thalidomide children remains the same however.  Not only is the cause different in the case of these children, but also there is a greater stress on the mother because of guilt feelings.  The above normal intelligence of the children themselves is another factor that make their case unique.  This article also includes comments on 2 other areas.  1 is the fact that family planning advice will be free to all patients when the National Health Service is reorganized in 1974.  The Times, in an article, put forth the view that free contraception for all is a good idea.


Anemia versus "anemia".

Anemia versus "anemia".


Shock and low-tension glaucoma.

Shock and low-tension glaucoma.


International journal of epidemiology.

International journal of epidemiology.


A public-health failure.

A public-health failure.


Arthritis during sickle-cell crisis.

Arthritis during sickle-cell crisis.


Nasogastric tube management.

Nasogastric tube management.


Communicable-disease theory of heroin addiction.


How many chiefs is too many chiefs?

How many chiefs is too many chiefs?


Care of the dying. 5. Listening to the dying.


Briggs explains.

Briggs explains.


A patient with meningioma.

A patient with meningioma.


Why they fail.

Why they fail.


The magic of dermatology. 1. Acute and chronic infections of the skin.


Modernizing night administration in a psychiatric hospital.


A medical smorgasbord.

A medical smorgasbord.


Evaluation of vagotomy and antrectomy for duodenal ulcer disease. Also a review of a 10 years experience with vagotomy and antrectomy in 104 patients.


Influenza status report.

Influenza status report.


Propoxyphene. Two fatalities due to overdose.


Determination of sample size.

Determination of sample size.


Recycling of Asian and Hong Kong influenza A virus hemagglutinins in man.


Two observed associations between respiratory allergies and hypertension in nonsmokers.


Testing for competence rather than for "intelligence".


Infectious hepatitis outbreak with mai tai as the vehicle of transmission.


Behavior innovation and persistence.

Behavior innovation and persistence.


To rear a child.

To rear a child.


Ethical principles in the conduct of research with human participants.


Conidiation of Aspergillus niger in continuous culture.


Fatty acids of a non-pigmented, thermophilic bacterium similar to Thermus aquaticus.


Assimilation of aliphatic hydrocarbons by Candida tropicalis. I. Analytical problems in hexadecane batch experiments.


Assimilation of aliphatic hydrocarbons by Candida tropicalis. II. Fatty acid profiles from cells grown on substrates of different chain length.


The effect of metabolic inhibitors on the loss of isocitrate lyase activity from Chlorella.


Metabolism of sulfur-containing amino acids in a patient excreting  -mercaptolactate-cysteine disulfide.


Urine polyelectrolytes: binding of phosphate, calcium and magnesium.


The automatic titration of bilirubin.

The automatic titration of bilirubin.


Chromatography of sugars in body fluids. IV. Separation of isomaltose and lactose in urine by paper chromatography.


Studies on the quantitative extraction of morphine from urine using nonionic XAD-2 resin.


Ubiquinone and related compounds. XXI. Determination of ubiquinone-10 in human blood.


Measurement of the initial rate of serum cholesterol esterification.


Procedures for the mass isolation of pure lipofuscins from normal human heart and liver.


The uptake and metabolism of  35 S-labeled volatile sulfur compounds by putrescent saliva.


Allopurinol and enzymes of de novo pyrimidine biosynthesis.


A clinical evaluation of an improved TFA micromethod for plasma and serum vitamin A.


Determination of ethane-1-hydroxy-1, 1-diphosphonic acid (EHDP) in human feces and urine.


Coccidioidin skin reactivity in pulmonary coccidioidomycosis.


Focal mononucleosis myocarditis simulating myocardial infarction.


Ouabain-induced hypertension in a patient with decompensated hypertensive heart disease.


Air embolism complicating percutaneous needle biopsy of the lung.


Endobronchial polyp.

Endobronchial polyp.


Treatment of propoxyphene overdosage with naloxone.


Pedunculated pericardial coelomic cyst manifesting as a rolling intrapleural mass.


Acute lupus pneumonitis: response to azathioprine therapy.


Tricuspid valve perforation by endocardial pacing electrode.


The electrocardiogram as a diagnostic aid in pneumothorax.


The breathing pattern in chronic obstructive lung disease during the performance of some common daily activities.


Dilemmas in drug nomenclature.

Dilemmas in drug nomenclature.


Pseudo complications of cardiac catheterization.


Changes in the pattern of old inferior wall myocardial infarction produced by acute left bundle branch block and hemiblock.


The reentry phenomenon: a common cardiac event.


Reentrant tachycardia: participation of the distal A-V conduction system.


Pulmonary dysfunction in rheumatoid disease.


Acute hypertensive effect of digitalis glycosides.


Opportunistic are the fungi.

Opportunistic are the fungi.


Pulsations of arm veins in the absence of tricuspid insufficiency.


The blood-air barrier in pulmonary asbestosis: study of a case by electron microscopy.


Splitting of the second heart sound: what is normality?


Tuberculosis discovered while performing thoracotomy for suspected lung cancer.


Postural variation in second sound splitting.


High speed trephine lung biopsy: methods and results.


Neuromuscular imbalance of the esophagus associated with hiatal hernia.


Course of chronic obstructive pulmonary disease following first onset of respiratory failure.


Extralobar and intralobar pulmonary sequestrations of the upper and lower lobes. Report of eleven cases, including one case of the scimitar syndrome.


Coarctation of the aorta and ventricular septal defect.


Atrial fibrillation with ventricular tachycardia showing "Dressler" beats.


Echocardiogram in atrial septal defect with small left-to-right shunt.


Regrowth of a left atrial myxoma.

Regrowth of a left atrial myxoma.


Pulmonary alveolar blood flow.

Pulmonary alveolar blood flow.


Effect of insulin on the performance and metabolism of the anoxic isolated perfused rat heart.


Inferior interatrial pathways in the dog.


Influence of brief vagal and stellate nerve stimulation on pacemaker activity and conduction within the atrioventricular conduction system of the dog.


Aortic valve leaflet motion during systole. Numerical-graphical determination.


Photoelastic stress analysis of silastic poppets in prosthetic heart valves.


Biphasic vasoconstriction of the rabbit ear artery.


A weighted least-squares technique for the analysis of kinetic data and its application to the study of renal xenon washout in dogs and man.


Dynamic anisotropic viscoelastic properties of the aorta in living dogs.


Approximating noncategorical teacher education.


Social perception in deaf and hearing adolescents.


The private residential program as another alternative to state institutions.


Use of deficits to identify the learning disabled.


Do gifted children speak an intellectual dialect?


Moles and malignant melanomas.

Moles and malignant melanomas.


Histopathology of clavi.

Histopathology of clavi.


The beneficial effects of leg motion during surgery.


Asceptic necrosis of the accessory navicular. A case report.


President's message.

President's message.


"Tennis toe".

"Tennis toe".


Fine structure of the Meissner corpuscle of human palmar skin.


Xeroderma pigmentosum variants: influence of temperature on DNA repair.


An electron microscopic study of human epidermis after acetone and kerosene administration.


Human sebaceous gland lipids: in vitro incubations with 14C-labelled compounds.


Serum glycoproteins in schistosomal hepatic fibrosis.


Immunoreactive insulin in schistosomal hepatic fibrosis.


Australia antigen AU(1) in school children in Ibadan, Nigeria.


Intestinal lactate activity in hookworm infestation.


Mass travel and health problems (with particular reference to Asia and the Pacific Region).


Isolation of salmonella from moderately polluted waters.


Microbial community structure in contaminated estuarian sediments.


An evaluation of open lung biopsy.

An evaluation of open lung biopsy.


The relationship between duration of exposure to cholera toxin and the secretory response of rabbit jejunal mucosa.


Prolonged serum half-life of cortisol in renal failure.


The Johns Hopkins Medical Institutions. A case study in administration.


Some observations on the effect of hypercapnea on ricketic cartilage calcification.


Delayed skeletal maturation in sickle cell anemia in Jamaica.


Perinatal tips.

Perinatal tips.


Primary amyloidosis of the renal pelvis: a case report and review of literature.


The cooperative Michigan primary care preceptor program. Its development, characteristics and objectives.


Paralytic shellfish poisoning.

Paralytic shellfish poisoning.


Portal and peripheral blood insulin response to oral glucose in states of carbohydrate intolerance.


Evaluation of fluocinonide cream.

Evaluation of fluocinonide cream.


Infant mortality in Michigan: situation improving, but much to be done.


The malpractice problem.

The malpractice problem.


Differential distribution of Australia-antigen-associated particles in patients with liver diseases and normal carriers.


Hepatitis B antigen particles and prognosis in hepatitis.


What's in an acronym: HMO or FMC?

What's in an acronym: HMO or FMC?


Intestinal adaptation.

Intestinal adaptation.


BCG vaccination in Massachusetts.

BCG vaccination in Massachusetts.


Platelet transfusion for quinidine-induced thrombocytopenia.


New unit for blood transfusion.

New unit for blood transfusion.


Outcome in pulmonary stenosis.

Outcome in pulmonary stenosis.


Coronary-care units.

Coronary-care units.


Clinical rubella after reinfection.

Clinical rubella after reinfection.


Vaccination for influenza.

Vaccination for influenza.


Vaginal adenosis: diagnosis by palpation.


Marihuana and alcohol intolerance in Hodgkin's disease.


Cryobanking of semen.

Cryobanking of semen.


Philosophy of medicine.

Philosophy of medicine.


Operations in USA, Canada and UK.

Operations in USA, Canada and UK.


Combined treatment of stage Ib carcinoma of the cervix.


Colposcopic diagnosis of cervical neoplasia.


Cervical biopsy versus conization.

Cervical biopsy versus conization.


Ultrastructure of ciliated cells in the human endometrium.


Reversibility of vulvar atypia by DNCB-induced delayed hypersensitivity.


Recurrent hydatidiform mole. A case report of nine consecutive molar pregnancies.


Ovarian cancer associated with pregnancy.


Uterine abscess formation secondary to endometrial cryosurgery.


Conservative surgery for ectopic pregnancy. A twenty-year review.


Episodic secretion of LH and FSH after ovariectomy. Secretory patterns in response to estrogen and progesterone. Patterns of LH and FSH secretion were studied in menopausal and ovariectomized subjects by frequent sampling and the influence of ovarian steroids upon these patterns was observed.  Subjects were 5 women who had been subjected to bilateral oophorectomy.  At 8:00 AM of Study Day 1 (control day), after fasting since midnight, 5 ml of venous blood was drawn and samples were taken at 20 minute intervals thereafter for a period of 8 hours.  Patency of the needle was maintained by a slow infusion of normal saline.  Blood serum was stored at - 20 degrees C.  The next day blood samples were similarly collected for 2 hours.  Then, in 2 patients, at 10:00 AM estradiol benzoate 1 mg was administered in a single dose, after which blood samples were collected at 20 minute intervals for an additional 6 hours.  On Day 3 the same procedure was followed, except that at 10:00 AM progesterone 100 mg was given in a single intravenous dose.  In 3 other patients the order of steroid administration was reversed so that progesterone was given on Study day 2 and estradiol on Day 3.  Serum LH and FSH concentrations were determined by double antibody radioimmunoassays.  Serum LH and FSH concentrations were increased in all patients.  During control periods serum LH levels fluctuated periodically in all subjects.  Serum FSH concentration varied episodically in 2 patients.  No synchronous pattern was noted either before or after the administration of the drugs.  After estradiol was administered on Day 2 to 2 patients, serum LH concentrations declined 39-55% from pretreatment levels and serum FSH levels decreased 15-20%.  In these patients episodic increases in both LH and FSH values were observed even after estradiol injection.  When progesterone was given on Day 2 and estradiol on Day 3, serum LH concentrations declined promptly.  Fluctuation of LH levels were apparent in 2 of the 3 patients.  FSH levels declined in only 1.  Progesterone alone had no effect on FSH levels.  Steroids seem to modify release of gonadotrophin rather than exert sole control over gonadotrophin release.


The gynecologic aspects of adrenal tumors.


Female genital self-mutilation.

Female genital self-mutilation.


The value of a routine prenatal chest X-ray.


The embryology of supernumerary ovaries.


The insertion of intrauterine devices by physicians and paramedical personnel.


Congenital anomalies in lead poisoning.

Congenital anomalies in lead poisoning.


Intrauterine contraceptive device and increased serum immunoglobulin levels.


Effect of ruptured membranes on fetal heart rate patterns.


Are we going to the supermarket?

Are we going to the supermarket?


Are we going to the supermarket? Editor's note.


Why not Pfannenstiel's incision?

Why not Pfannenstiel's incision?


Usefulness of rapid blood glucose measurements in obstetrics. Dextrostix/reflectance meter system.


Obstetric lubricant.

Obstetric lubricant.


Abnormal sex determination and differentiation in man.


Placentophagy.

Placentophagy.


Warning on contraceptive packaging.

Warning on contraceptive packaging.


Expectancy and magnitude of reaction to a noxious UCS.


Some limits on the cognitive control of conditioned autonomic behavior.


Cognitive processes and the multiple response phenomenon.


Cognitive factors and conditioning: an overview.


Auditory feedback and conditioning of the single motor unit.


Latency of alpha blocking as a function of photic stimulation during the cardiac cycle.


Effects of night duty on sleep patterns of nurses.


Habituation during sleep.

Habituation during sleep.


Peak identification in visual evoked potentials.


On the distinction between conditioning and pseudoconditioning.


Photoplethysmography: system calibration and light history effects.


Classical conditioning and the cognitive processes: a symposium.


Can classical conditioning occur without contingency learning? A review and evaluation of the evidence.


Is there classical conditioning without cognitive expectancy?


The relation between heart rate and electromyographic activity in a discriminated escape-avoidance paradigm.


The role of awareness in differential conditioning.


Unexpected effects of masking: differential EDR conditioning without relational learning.


The dangers of asbestos.

The dangers of asbestos.


Anaesthesia for prolonged laryngeal microsurgery in adults.


Asbestos and malignancy.

Asbestos and malignancy.


Treatment of advanced carcinoma of the prostate by yttrium-90 ablation.


Clinical features of adenocarcinoma of the kidney.


Tay-Sachs disease in South Africa.

Tay-Sachs disease in South Africa.


A case of appendicitis simulating ruptured ectopic pregnancy.


Hepatic glycogen storage during uncontrolled diabetes mellitus. A case report.


Lymphocytic infiltration in bladder cancer: a preliminary report.


Alpha methyldopa and haemolytic anaemia.


Evoked potential correlates of expected stimulus intensity. The electrophysiological responses to a flash of medium intensity have different wave shapes in trials in which the occurrence of bright stimuli or dim stimuli is expected. When a bright or dim stimulus is signaled, the potentials evoked by the medium stimulus resemble the responses evoked by a real bright or dim flash.


Traumatic hyphema. A report of 184 consecutive cases.


Trachoma and other eye disease in a New Guinea village.


Low-vision aids for partially sighted persons.


Aplastic anemia resulting from the use of carbonic anhydrase inhibitors.


Lipreading performance as related to visual acuity.


Photocoagulation of disciform macular lesions in the ocular histoplasmosis syndrome.


Case report of successful treatment of a reflex trigeminal nerve blepharospasm by behavior modification.


Translated myokymia of the lower eyelid causing uniocular vertical pseudonystagmus.


The ophthalmology basic and clinical science course.


Actinomycotic lacrimal canaliculitis.

Actinomycotic lacrimal canaliculitis.


Affinity for retinal pigment epithelium by certain viruses.


Photocoagulation therapy of branch vein obstructions.


A clinical study of the vascularity of senile disciform macular degeneration.


Morbidity and survivorship of patients with embolic cholesterol crystals in the ocular fundus.


Plasma cortisol suppression in glaucoma.


Cystoid macular edema following aphakic keratoplasty.


Pathogenesis of the posterior segment lesion of ocular onchocerciasis.


Intraocular pressure response to experimental alkali burns.


Promoting the adoption of social work services by hospitals and health departments.


Chinese health care: determinants of the system.


A derivation of clinic capacity.

A derivation of clinic capacity.


Survey of infant feeding practices.

Survey of infant feeding practices.


Planning for family planning.

Planning for family planning.


New York State physicians and the social context of abortion.


Some factors influencing the distribution of premature death from coronary heart disease in Nova Scotia.


Public health and family planning--a study of inter-relationship in India.


The distribution of lead paint in New York City tenement buildings.


Population education not crisis education. Population education should be taught in the schools, not in response to a crisis, but as a means of providing knowledge and concepts to children.  This may obviate future population crises.  By treating population education as a crisis reaction, the effect of education is overrepresented; teachers and students are frustrated in not achieving the goal.  The National Education Association publication of 1943 called for the introduction of population education into the schools.  If it had been done then, we would have less of a gap between the concern of today's students and their knowledge.  The level of understanding of leaders might be higher.  Policy makers would not expect immediate results from population programs.


Serum parameters in hard and soft water communities.


Centennial presidential address: policy, priority, and the power to act.


Field-dependence and lateralization of function in the human brain.


Schizophrenic pathology in young adults. A clinical study.


A longitudinal study of schizophrenic thinking.


Psychomotor epilepsy and aggressive behavior.


Toward a more efficient mental status examination. Free-form or operationally defined.


The stages of mania. A longitudinal analysis of the manic episode.


Cerebrospinal fluid MHPG. An assessment of norepinephrine metabolism in affective disorders.


Alcohol problems in adoptees raised apart from alcoholic biological parents.


Nonmetric pattern analysis of behavioral and biological disease symptoms in alcoholism.


Chronic anxiety treated by feedback-induced muscle relaxation. A pilot study.


Brief and prolonged flooding. A comparison in agoraphobic patients.


9 -Transtetrahydrocannabinol and natural marihuana. A controlled comparison.


Methadone--a reevaluation.

Methadone--a reevaluation.


Comparison of phycoerythrins (542, 566nm) from cryptophycean algae.


The use of human skeletal muscle in vitro for biochemical and pharmacological studies of glucose uptake.


Lack of histological evidence of vitamin D abnormality in the bones of anephric patients.


The effects of intravenous infusion of graded doses of prostaglandins F 2   and E 2  on lung resistance in patients undergoing termination of pregnancy.


Changes in fat and carbohydrate metabolism caused by moderate exercise in patients with acromegaly.


A new method for monitoring deep body temperature from the skin surface.


Plasma zinc in pre- and post-menopausal women: its relationship to oestrogen therapy.


Streptococcal control in Colorado.

Streptococcal control in Colorado.


The new anti-intellectualism.

The new anti-intellectualism.


What the clinician needs to know about electrocardiography. What is your diagnosis?


Connecticut Regional Medical Program. Health care planning.


Introductory remarks: quantity, quality, and temptations in streptococcal control.


Streptococcal control in schools: the Wyoming program.


Streptococcal infections and their control in the inner city: the Sinai-Druid, Baltimore experience.


The occurrence of dibutyl phthalate in American cockroaches.


Colorimetric estimation of acidic polysaccharide content of Gymnodinium breve.


Removal of hydrocarbon exhaust interference in ethylene-ozone chemiluminescent instruments.


Interaction of humic acid with chlorinated phenoxyacetic and benzoic acids.


Pharmacy service for university health.

Pharmacy service for university health.


The Detroit 'quadrangle'.

The Detroit 'quadrangle'.


Food service: training, job enrichment reduce costs.


Law of consent and abortion in California.


What's a clinical engineer?

What's a clinical engineer?


The clinical nurse specialist.

The clinical nurse specialist.


Beyond acute, inpatient care.

Beyond acute, inpatient care.


Facilities to accommodate emerging patterns of care. GAO studies construction costs.


Consumer involvement in community planning.


Shorter distance to the office.

Shorter distance to the office.


Shared services--complex, but rewarding.


Facilities for extended care.

Facilities for extended care.


Kellogg's role in fostering shared services.


Updating, expanding outpatient facilities.


Housing project is part of preventive care program.


Congenital syphilis, a new (old) diagnostic problem.


The case of the incredibly impossible.

The case of the incredibly impossible.


Spontaneous rupture of the urinary bladder.


State Health Department sickle cell testing and counseling program.


Study of maternal mortality.

Study of maternal mortality.


Underground coal mine injuries.

Underground coal mine injuries.


Hypokalemia due to massive villous adenoma of the rectum.


MECO--medical education and community orientation.


Consumerism.

Consumerism.


Mediastinal opacity.

Mediastinal opacity.


Hodgkin's disease or lymphoma? A problem in staging.


X-linked hereditary spastic paraplegia.

X-linked hereditary spastic paraplegia.


Use and abuse of drains in abdominal surgery.


Developmental and adult morphology of the vertebral column in the plethodontid salamander Eurycea bislineata, with comments on vertebral evolution in the amphibia.


Heart development in the Mexican salamander, Ambystoma mexicanum. I. Gross anatomy, histology and histochemistry.


Palatogenesis in hamster. II. Ultrastructural observations on the closure of palate.


Effects of dietary protein content and ratio of fat to carbohydrate calories on energy metabolism and body composition of growing rats.


Energy metabolism in atherosclerosis-resistant and -susceptible pigeons.


Anemia, iron storage and ceruloplasmin in copper nutrition in the growing rat.


Effect of dietary protein on the intestinal biosynthesis of retinol from  14 C- -carotene in rats.


Effect of diets devoid of one essential amino acid on pregnancy in rats maintained by ovarian steroids.


Effects of vascular insufficiency on placental ribonuclease activity in the rat.


Vitamin E-selenium deficiency and its influence on avian malarial infection in the duck.


Effect of various carbohydrates in a repletion diet after protein depletion on liver lipid content of rats.


Development of renal gluconeogenesis in chicks fed high fat and high protein "carbohydrate-free" diets.


Utilization of methionine for phospholipid formation as affected by dietary protein in the rat.


Oxygen consumption by brain mitochondria of rats malnourished in utero.


Protein deficiency: turnover of protein and reutilization of amino acid in cell fractions of rat liver.


Obesity, hyperinsulinism, and diabetes mellitus in childhood.


Familial nephrotic syndrome with nephrocalcinosis and tubular dysfunction.


Aspirin-induced asthma in children.

Aspirin-induced asthma in children.


Valvar aortic stenosis in childhood: clinical and hemodynamic history.


Isovaleric acidemia: identification of isovalerate, isovalerylglycine, and 3-hydroxyisovalerate in urine of a patient previously reported as having butyric and hexanoic acidemia.


Metabolic aspects of the Beckwith-Wiedemann syndrome.


Duplication-deficiency product of a pericentric inversion in man: a cause of D 1  trisomy syndrome.


Physiologic deficiency of pancreatic amylase in infancy: a factor in iatrogenic diarrhea.


Congenital subglottic stenosis.

Congenital subglottic stenosis.


Urinary excretion of 5-hydroxyindolacetic acid in low-birth-weight infants with and without phototherapy.


Triiodothyronine in cord serum.

Triiodothyronine in cord serum.


Age of menarche: a changing pattern and its relationship to ethnic origin and delinquency.


A suction-controlled nasal aspirator for collection of nasopharyngeal secretions.


The campomelique syndrome.

The campomelique syndrome.


The hemolytic-uremic syndrome in California: a review of 28 nonheparinized cases with long-term follow-up.


Oral urea therapy in children with sickle cell anemia.


Neonatal cyanosis and arterial oxygen saturation.


"Therapeutic success" in Reye's syndrome.


The practitioner's role in behavioral pediatrics.


Calcium excretion in cystic fibrosis.

Calcium excretion in cystic fibrosis.


Medical communications: relation to school health services.


Antiepileptic drugs and development of rickets.


Syndrome of microcephaly, cataracts, kyphosis, and joint contractures versus Cockayne's syndrome.


NBT test in thalassemia.

NBT test in thalassemia.


Phenobarbital and alkaline phosphatase.

Phenobarbital and alkaline phosphatase.


Alkaline phosphatase values in children.


The value of collaboration: the California model.


T 4 -mediated v-gene reactivation of UV-irradiated phage Ti, and its comparison with host-cell reactivation.


Photoreactivation and repair replication in rat kangaroo cells.


Chromosomal studies in vivo and in vitro of trimethoprim and sulphamethoxazole (co-trimoxazole).


Caffeine potentiation of the chromosome damage produced in bean root tips and in Chinese hamster cells by various chemical and physical agents.


Relative radiosensitivities of tetraploid and diploid Chinese hamster cells in culture exposed to ionizing radiation.


Investigations on the effect of phenylbutazone on chromosomes and mitosis in the bone marrow of rats.


Cytotoxicity and mutagenicity of ultraviolet irradiation as a function of the interval between split doses in cultured Chinese hamster cells.


Varicose ulcers--a nurse's province?

Varicose ulcers--a nurse's province?


Anorexia nervosa--some aspects of nursing management.


Blood gases. 2.

Blood gases. 2.


The magic of dermatology. 3. Animal parasites.


Water on the knee.

Water on the knee.


Care of the dying. 7. Religion and the care of the dying.


Taming of the shrew.

Taming of the shrew.


The thin blue line.

The thin blue line.


Organizing psychogeriatric care in the community.


Factors related to violent and unpredictable behaviour in psychiatric hospitals.


Colonoscopy.

Colonoscopy.


Reflections on health visitor training.

Reflections on health visitor training.


A case of paraquat poisoning.

A case of paraquat poisoning.


Terminal care.

Terminal care.


Computers in the ward situation.

Computers in the ward situation.


The magic of dermatology. 4. Functional disorders of the skin.


A slightly neglected area?

A slightly neglected area?


Prevention versus cure.

Prevention versus cure.


Half way home.

Half way home.


The graduate-nurse expansion.

The graduate-nurse expansion.


The genetics of thanatophoric dwarfism.

The genetics of thanatophoric dwarfism.


The child health associate: comments of a practicing pediatrician.


The child health associate--what's in a name?


Blood sampling from scalp arteries in infants.


Intracranial hemorrhage and subsequent communicating hydrocephalus in a neonate with classical hemophilia.


Phototherapy in nonobstructive, nonhemolytic jaundice.


"Purse" poisons.

"Purse" poisons.


Selective intra-arterial vasopressin in the management of stress ulcers in childhood.


Warning: the use of lomotil in children.


Committee on radiology: radiation protection in diagnostic radiography of children.


Committee on adoption and dependent care: transracial adoption.


Alert practitioner program.

Alert practitioner program.


The school physician.

The school physician.


The school physician and his role: a constructive conclusion.


Medical evaluation for reading disability--last time around.


Clinical evaluation of the VMA test strip.


Vitamin K, hepatic fatty infiltration, and Reye's syndrome.


The Child Health Associate: a new health professional to provide comprehensive health care to children.


Paroxysmal tachycardia in infancy: follow-up study of 47 subjects ranging in age from 10 to 26 years.


Reversal of selective IgA deficiency in a child with juvenile rheumatoid arthritis after plasma transfusions.


IgA synthesis by jejunal biopsies from patients with cystic fibrosis and hereditary pancreatitis.


Ultrasonically guided suprapubic urinary bladder aspiration.


Epidermoid cysts of the spleen.

Epidermoid cysts of the spleen.


Utilization of child health associates by a practicing pediatrician.


Solitary thyroid nodules in 30 children and report of a child with a thyroid abscess.


Pulmonary hypoplasia: a morphometric study of the lungs of infants with diaphragmatic hernia, anencephaly, and renal malformations.


The total synthesis of vitamin B 12 .

The total synthesis of vitamin B 12 .


Some recent studies on the metabolites of fungi and lichens.


Biosynthetic pathways in chemical phylogeny.


Some aspects of the chemistry of penicillin.


The microbiological hydroxylation of steroids and related compounds.


Some new trends in the chemistry of polysaccharides.


Herniation of the bladder.

Herniation of the bladder.


Salivary secretion of iodine after urography. Further evidence for in vivo deiodination and salivary secretion of contrast media.


The angiographic appearance of the heart following the Mustard procedure.


Posterior left ventricular pseudoaneurysm. Angiographic-pathologic correlation.


The importance of inferior vena cavography in placement of the Mobin-Uddin vena caval filter.


Sigmoid mesenteric cyst. Angiographic findings.


Luetic lymphadenitis: lymphographic manifestations simulating lymphoma. Report of a case.


Experience with MARS (Missouri Automated Radiology System).


Agenesis of the gallbladder. Is preoperative diagnosis possible?


A method of radiological demonstration of the temporomandibular joints using the orthopantomograph.


Unusual osteosclerotic changes in sarcoidosis, simulating osteoblastic metastases.


Relapsing polychondritis.

Relapsing polychondritis.


Routine biplane magnification cerebral angiography.


Delayed arterial spasm following subarachnoid hemorrhage.


Intracranial subarachnoid cysts.

Intracranial subarachnoid cysts.


Carotid ergotism. A complication of migraine therapy.


Frontal lucency sign on brain scans.

Frontal lucency sign on brain scans.


Reversible unilateral pulmonary hypoperfusion secondary to acute check-valve obstruction of a main bronchus.


Roentgenographic manifestations of immaturity of the intestinal neural plexus in premature infants.


Radiographic abnormalities of the duodenum and small bowel in cystic fibrosis of the pancreas (mucoviscidosis).


The late gastrointestinal manifestations of cystic fibrosis of the pancreas.


The double gastric fluid level in kerosene poisoning.


Visualization of individual papillary ducts (ducts of Bellini) by excretory urography in childhood hydronephrosis.


Pseudoectopic ureter on prone urogram.

Pseudoectopic ureter on prone urogram.


Separation of the entire distal humeral epiphysis.


Thanatophoric dwarfism and cloverleaf skull ("kleeblattschädel").


Histiocytosis X: role of radiation therapy in management with special reference to dose levels employed.


An evaluation of long-term survivors treated for cancer of the esophagus with preoperative x-ray therapy.


A large-area germanium detector for rectilinear scanning.


Computer and approximation methods of calculating depth dose in irregularly shaped fields.


A catheter technique for the production of communicating hydrocephalus.


99m Tc-pertechnetate scintigraphy as an aid in the diagnosis of breast masses.


The use of iodinated fibrinogen for localization of deep venous thrombi by scintiscanning.


Radiosensitivity of confluent density-inhibited cells.


Teletherapy strip filter.

Teletherapy strip filter.


Disposable afterloading colpostats (spheroids) for all radioactive sources.


Angiotomography: integrated laminagraphy and selective renal angiography.


Simple and safe radionuclide injection technique.


Nonoperative removal of a bronchial foreign body.


Simplified method of exchanging clotted intravascular catheters.


Letter from the editors.

Letter from the editors.


Rose bengal excretion studies as an aid in the differential diagnosis of neonatal jaundice.


Radionuclide techniques in pediatric hematology.


Founder effect in Tay-Sachs disease.

Founder effect in Tay-Sachs disease.


The effect of diagnostic ascertainment in twins on the assessment of the genetic factor in disease etiology.


Further evidence of sex-linked major-gene influence on human spatial visualizing ability.


Survey for erythrocyte glucose-6-phosphate dehydrogenase deficiency in Fiji.


An extension of migration matrix analysis to account for differential immigration from the outside world.


Bioassay of kinship in a South American Indian population.


Utilization of eponychium for genetic studies.


Operating room electrical environment and the anesthesiologist.


The distribution of radiofrequency current and burns.


Effects of methoxyflurane on canine cerebral metabolism and blood flow.


Laryngeal competence with ketamine and other drugs.


Pulmonary function after ventilation with fluorocarbon liquid (Caroxin-D).


The effect of depolarizing relaxants on the neuromuscular refractory period of anesthetized man.


Electrocution in the operating room.

Electrocution in the operating room. The manner in which a patient sustained an electrical shock injury from improperly wired equipment during the course of an operation was described in order to acquaint others with a potentially hazardous situation.  A patient requiring surgical treatment had the ground plate of an electrocautery unit placed under her buttocks and the electrodes of an EKG unit attached to her shoulders and her precordium.  During the course of the operation, the EKG monitor was subject to electrical interference.  In an effort to correct the problem, the surgeon instructed the nurse to unplug the monitor and reinsert the plug into a 2nd wall receptable.  As the plug was reinserted, the physician suffered a minor shock and the patient experienced an intense shock.  She became cyanotic and her pulse stopped.  The patient was revived and later recovered completely.  Inspection of the equipment revealed that the EKG's power plug was incorrectly wired.  The chassis ground was connected to the neutral plug instead of the ground plug.  Furthermore, the 2nd wall receptacle was wired with reversed polarity.  When the plug was inserted into the 2nd receptacle, a 110 volt alternating current developed between the precoidal EKG lead and the ground plate.  If the monitor had been plugged into the 2nd receptacle prior to the operation, the monitor would not have functioned.  The technician probably would have assumed that the machine was not in working order and would have substitued another machine.  In order to minimize electrical shocks, EKG leads should be applied only to the extremities and not to the precordium region.


The lack of effect of lidocaine on oxyhemoglobin dissociation.


Aortic pressure versus Doppler-measured peripheral arterial pressure.


Rebreathing bags as pressure-limiting devices.


Controlled evaluation of ultrasonic measurement of systolic and diastolic blood pressures in pediatric patients.


Intertissue diffusion of anesthetics.

Intertissue diffusion of anesthetics.


Interferon and the cellular immune response: separation of interferon-producing cells from DNA-synthetic cells.


Two categories of lymphocyte unresponsiveness to phytohemagglutinin.


In vitro mechanism of human lymphotoxin action: destruction of nondividing target cells.


Thymus cell subpopulations separated on discontinuous BSA gradients: antigenic properties and circulation capacity.


Immune response to chemically modified flagellin. IV. Further studies on the relationship between humoral and cell-mediated immunity.


Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver disease.


A medical school for Maine: the commitment of the Maine Medical Association.


Cervical thymic cyst. A consideration in the differential diagnosis of neck masses.


Survival of a diabetic patient with perirenal emphysema.


A position paper from the state office of comprehensive health planning. The need for certificate of need authority towards building a model health system for Maine.


The community hospital. Its possible role in medical education.


Retrovesical cysts in boys.

Retrovesical cysts in boys.


Notes on the Boyce-Vest operation for exstrophy of the bladder.


Renal cortical rest and chronic hematuria. A syndrome treated by mid-kidney partial nephrectomy.


Treatment of epispadias with and without urinary incontinence. Experience with 46 patients.


Replacement of ureterostomy tubes. A new technique using a directable catheter and fluoroscopic control.


An unusual surgical injury to the ureter.


Late results of an ileocystoplasty. A 12-year followup.


Experiences with vesicoureteral reflux.

Experiences with vesicoureteral reflux.


Massive bladder hemorrhage after cystoscopy in a patient with secondary systemic amyloidosis.


Bladder lymphatics and tumor dissemination.


Ultrasonically guided renal cyst aspiration.


Gartner's duct cyst involving urinary tract.


The treatment of prostatic bone metastases with parathormone and radioactive phosphorus.


Experience in the treatment of prostatic carcinoma with cyproterone acetate.


Effect of exogenous estrogen and progesterone upon sex chromatin frequency.


Structure and composition of urinary calculi.


Urinary tract sterility and indwelling catheters.


Abacterial pyuria.

Abacterial pyuria.


Retroperitoneal phlegmon. A fatal complication of retrograde pyelography.


Current status of prognostic criteria in neuroblastoma.


Cure of hypertension in a child with renal artery stenosis and hydronephrosis in a solitary kidney.


Nurse or Feldscher.

Nurse or Feldscher.


Blood gasses. 1.

Blood gasses. 1.


The magic of dermatology. 2. Itching.

The magic of dermatology. 2. Itching.


Psychosocial nursing in the community.

Psychosocial nursing in the community.


Durham advance.

Durham advance.


The medical aspects of driving a car.

The medical aspects of driving a car.


Nursing and midwifery resources.

Nursing and midwifery resources.


Attention and heart rate: a critical appraisal of the hypothesis of Lacey and Lacey.


Relation between signal detectability theory and the traditional procedures for measuring thresholds. An addendum.


Processes of fear reduction in systematic desensitization: an addendum to Wilson and Davison (1971).


Correlation between genetically matched groups versus reliability theory: a reply to Jensen.


What can one man do?

What can one man do?


Cervical node metastases from occult primary sites.


"What's the rhythm"?"What's the rhythm?

"What's the rhythm"?"What's the rhythm?


Closure of atrial septal defects in adults.


Recurrent melanoma presenting with obstructive jaundice. Report of two cases.


Keeping up with the journals. A prescription for more effective reading.


The origins of nerve-cell specificity.

The origins of nerve-cell specificity.


Fishes with warm bodies.

Fishes with warm bodies.


Function of top component a RNA in the initiation of infection by alfalfa mosaic virus.


The "in vivo" production of "new" influenza viruses. 3. Isolation of recombinant influenza viruses under simulated conditions of natural transmission.


Intermediates in type 5 adenovirus DNA replication.


Comparison of molecular weights of single-stranded viral RNAs by two empirical methods.


Viruslike particles in salivary glands of leafhoppers Endria inimica.


Structural proteins of adenoviruses. IX. Molecular weight and subunit composition of adenovirus type 2 fiber.


Chrysanthemum stunt: a viroid disease.

Chrysanthemum stunt: a viroid disease.


Isotope liquorgraphy in the demonstration of communicating obstructive hydrocephalus after severe cranial trauma.


The level and circadian rhythm of plasma free 11-hydroxycorticoids in patients with localized intracranial processes, especially of the sellar region.


Benign recurrent aseptic meningitis of unknown aetiology (Mollaret's meningitis).


Fibrinolytic activity of the cerebrospinal fluid after subarachnoid haemorrhage.


Involvement of the autonomous nervous system in primary and secondary amyloidosis.


Cerebrospinal uric acid in alcoholics.

Cerebrospinal uric acid in alcoholics.


Acute effect of section of the corpus callosum upon "independent" epileptiform activity.


Serial hyperthermia testing in multiple sclerosis: a method for monitoring subclinical fluctuations.


Virus antibodies in serum specimens from patients with multiple sclerosis, from siblings, and matched controls. A final report.


Effect of 2-deoxy-D-glucose on growth and cell walls of Schizosaccharomyces pombe 972h.


Some aspects of germination induction in Phycomyces blakesleeanus by an ammonium-acetate pretreatment.


Studies on the growth of Thiobacillus ferrooxidans. I. Use of membrane filters and ferrous iron agar to determine viable numbers, and comparison with  14 CO 2 -fixation and iron oxidation as measures of growth.


Studies on a gram-positive hydrogen bacterium, Nocardia opaca strain 1 b. I. Description and physiological characterization.


Studies on a gram-positive hydrogen bacterium, Nocardia opaca strain 1 b. II. Enzyme formation and regulation under the influence of hydrogen or fructose as growth substrates.


Influence of copper and zinc ions on toxicity of sodium N-methyldithiocarbamate to Fusarium oxysporum f. sp. lycopersici.


Investigations on the mode of action of sodium N-methyldithiocarbamate in Fusarium oxysporum f. sp. lycopersici.


The effect of K +  on the membrane potential in HeLa cells.


Weak association of glucosamine-containing polymer with the Acholeplasma laidlawii membrane.


Isolation and characterization of agglutinin receptor sites. II. Isolation and partial purification of a surface membrane receptor for wheat germ agglutinin.


Hemolysis induced by Prymnesium parvum toxin calorimetric studies.


Some aspects of the osmotic lysis of erythrocytes. I. A reexamination of the osmotic lysis method.


Some aspects of the osmotic lysis of erythrocytes. II. Differences in osmotic behaviour of erythrocytes after treatment with electrolyte and non-electrolyte solutions.


Some aspects of the osmotic lysis of erythrocytes. 3. Comparison of glycerol permeability and lipid composition of red blood cell membranes from eight mammalian species.


Path of osmotic water flow through rabbit gall bladder epithelium.


Effects of freezing on biological membranes in vivo and in vitro.


Kinetic characterization of the chloride dependence of sodium transport in the frog skin.


Intramucosal gastric acid concentration determined by glass microelectrode technique.


Effect of cycloheximide on influx across the brush border of rabbit small intestine.


Bilirubin uptake in vitro by the rat intestinal mucosa.


A synthetic transmembrane channel.

A synthetic transmembrane channel.


Phospholipid metabolism in rat liver endoplasmic reticulum. Structural analyses, turnover studies and enzymic activities.


Simulation of microsome sedimentation.

Simulation of microsome sedimentation.


Research into marijuana.

Research into marijuana.


Infant fallout.

Infant fallout.


Vitamin C and the common cold.

Vitamin C and the common cold.


Irradiation of the hypophysis.

Irradiation of the hypophysis.


The neurophysiological basis of the marijuana experience. Experiments were done with 75 healthy young adults to explore the neurophysiological basis of the acute marijuana intoxication state. Tests included recording the scalp EEG, visual and auditory cerebral evoked-potentials, the CNV, cerebral slow potentials related to certainty of response correctness in auditory discrimination tasks, heart rate, respiration and the galvanic skin response. All variables were recorded over 45 minutes before and 45 minutes after smoking a marijuana cigarette containing either 4.8, 9.1 or less than 0.01 mg. Delta(9)-THC.High doses of marijuana induced a significant decrease in the peak power of the alpha rhythm and an increase in auditory evoked-response latency. The CNV increased in ampiitude after smoking marijuana in low doses and sequential CNVs showed changes consistent with sustained attention but decreased certainty about performance following either low or high dose. Marijuana interfered significantly with performance of the discrimination task itself.


Halothane hepatitis.

Halothane hepatitis. This report describes five cases of hepatocellular injury following halothane anesthesia. Four patients had multiple exposures to the anesthetic. Three of the five died from submassive to massive liver cell necrosis. The two survivors developed jaundice and/or dark urine following each exposure to halothane; liver biopsy in one showed centrilobular and linear areas of necrosis. Fever, anorexia, nausea, vomiting, abdominal pain and jaundice were present in all cases. In the two survivors the prothrombin time was less than 20 seconds throughout the course of the disease, whereas in the three who died the prothrombin time was more than 20 seconds from the onset. The English literature to the end of 1971 is reviewed. Approximately 600 cases of halothane-related hepatitis have been reported


Systemic corticosteroids in alopecia totalis. Two cases of alopecia totalis are presented and some observations made on the course and treatment of the disorder. The stimulus for extensive alopecia areata appears to occur for short periods in at least some cases and may, therefore, be amenable to shorter courses of systemic corticosteroids than was formerly thought possible. Discontinuing systemic therapy does not always result in a rapid recurrence of totalis and bouts of alopecia partialis which may follow its discontinuance may be managed by more conservative means. In addition, areas resistant to 30 mg. of prednisone per day may respond to topical and intralesional therapy even while prednisone is being reduced considerably below this level.


Measurement of the rate of stomach emptying using Indium-113m and a 10-crystal rectilinear scanner. Accurate reproducible measurements of the rate of gastric emptying have only been possible since the advent of external radionuclide detection techniques. Indium-113m and a 10-crystal rectilinear scanner have been employed to measure stomach emptying rates. The technique is simple, the results reproducible and it has proved ideal for assessing the results of drug therapy in patients with gastric retention. In the normal individual the T50% was 42 to 95 minutes, and the relationship between counts and time was, to first approximation, a linear function.


The successful stock market investor.

The successful stock market investor.


A neurological form of schizophrenia.

A neurological form of schizophrenia. A case is described of a young woman who first showed manifestations of schizophrenia in childhood. At the age of 13 years evidence was present of what was authoritatively diagnosed as a progressive degenerative cerebellar syndrome and her condition continued to deteriorate. Improvement commenced shortly after the institution of megavitamin therapy, notably nicotinic acid 3 grams daily. Her subsequent educational progress was satisfactory and her social rehabilitation is now complete. No medication other than nicotinic acid is required.


Trimethoprim--sulphamethoxazole in intestinal and lung infections.


Cephradine. Antibacterial activity and clinical effectiveness.


What is the future of biomedical science?


A national foundation for biomedical research?


Membranes in growth, differentiation and neoplasia. Introduction.


Science, politics and regulation.

Science, politics and regulation.


2,4-diaminopentanoic acid C 4  dehydrogenase. Purification and properties of the protein.


Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification.


Structure of two histidine-containing crosslinks from collagen.


Macromolecular composition of an amoeba plasma membrane.


Glucocorticoid-binding macromolecules in rat and mouse thymocytes.


Lack of mammalian reduction or alkylation of 24-methylenecholesterol.


The binding properties of dimeric and tetrameric concanavalin A. Binding of ligands to noninteracting macromolecular acceptors.


Characterization of monellin, a protein that tastes sweet.


Fractionation and partial characterization of proteins of the bileaflet nuclear membrane from rat liver.


Transport of ornithine and citrulline across the mitochondrial membrane.


A sedimentation equilibrium study of the interaction between ovalbumin and lysozyme.


The effect of epinephrine, glucagon, and the nutritional state on the oxidation of branched chain amino acids and pyruvate by isolated hearts and diaphragms of the rat.


Retinol glycolipids.

Retinol glycolipids.


Intracellular collagen and protocollagen from embryonic tendon cells.


Chemical studies on the subunit structure of rabbit muscle phosphoglucose isomerase. Identification of N-acetylated NH 2 -terminal alanine and COOH-terminal glutamine.


Influence of kynuremate on cholesterol and fatty acid synthesis in isolated perfused rat liver.


Pyruvate kinase isozymes from rat tissues. Developmental studies.


Histones in chick embryonic erythropoiesis.


Isolation and structural determination of a novel ganglioside, a disialosylpentahexosylceramide from human brain.


Photoselection and linear dichroism of retinals. A method for identification and measurement of various geometrical isomers.


Properties of nuclease-resistant fragments of calf thymus chromatin.


Progesterone-binding plasma protein of pregnant guinea pig. Purification and characterization.


Identification of the amide II band in the cis-amide 1-methyluracil, in poly(U), and in poly(A)-poly(U).


Isolation of three isoinhibitors of trypsin from garden bean, Phaseolus vulgaris, having either lysine or arginine at the reactive site.


The stereochemistry of pyridoxal phosphate enzymes. The absolute stereochemistry of cofactor C' 4  protonation in the transamination of holoserine hydroxymethylase by D-alanine.


Blood group A active glycoproteins of respiratory mucus and their synthesis by an N-acetylgalactosaminyltransferase.


Preparation and studies of  19 F-labeled and enriched  13 C-labeled semisynthetic ribonuclease-S' analogues.


Bovine liver crotonase. Substrate analogs and chemical modification of cysteinyl residues.


The solution conformation of the ferrichromes. V. The hydrogen exchange kinetics of ferrichrome analogues; the conformational state of the peptides.


The solution conformation of the ferrichromes. IV. pH dependence of the individual slow amide hydrogen-deuterium exchange in alumichrome.


Sugar transport. V. A trimeric lactose-specific phosphocarrier protein of the Staphylococcus aureus phosphotransferase system.


Sugar transport. VI. Phosphoryl transfer in the lactose phosphotransferase system of Staphylococcus aureus.


Sugar transport. VII. Lactose transport in Staphylococcus aureus.


On the interpretation of Michaelis constants for transport.


Acetylation of ribosomal proteins. I. Characterization and properties of rat liver ribosomal proteins.


Dihydrofolate reductase. Studies on the activation of the bovine liver enzyme.


Cancer mortality among uranium mill workers.


Metallic mercury exposure in scientific glassware manufacturing plants.


A kit for hand recovery following injury.


Evaluation and referral of drug abusers within business settings.


Alpha 1 -antitrypsin deficiency as an indicator of susceptibility to pulmonary disease.


Systemic fluoride poisoning resulting from a fluoride skin burn.


The basis for a preventive cardiovascular program.


Heart disease prevention in industry: role of the medical director.


Heart disease prevention in industry: the union's role and the worker's stake in heart disease prevention.


Critical issues seminar program.

Critical issues seminar program.


Heart disease prevention in industry. Primary prevention in mass community efforts to control the major coronary risk factors: the challenges and possibilities--critical issues and outlook for the future.


Measurement of microvascular diameter by a sensor scan technique.


Chamber techniques to study the microvasculature.


Symposium on capillary exchange and the interstitial space. Bad Durkheim, Germany. May 3-6, 1972.


Stochastic flow in capillary blood vessels.


Observations of microcirculation in the mesentery of DCA hypertensive rats.


Intrinsic microvascular control of tissue oxygen delivery.


Membrane potential and contraction of vascular smooth muscle (portal vein) during application of noradrenaline and high potassium, and selective inhibitory effects of iproveratril (verapamil).


Blood flow in capillaries.

Blood flow in capillaries.


Ion etching of red cell membrane.

Ion etching of red cell membrane.


Relationship between capillary wall structure and "effective" transcapillary osmotic pressure.


Acute respiratory distress in adults.

Acute respiratory distress in adults.


Flow cell evaluation of nonthrombogenic materials.


Radiation exposure to personnel during cardiac catheterization.


The role of the Y and Z hepatic proteins in the excretion of radiographic contrast materials.


Association of subcapsular hematomas with the nonfunctioning kidney.


Renin-secreting juxtaglomerular-cell adenoma. Preoperative clinical and angiographic diagnosis.


Abnormal excretory urogram and lymphangiogram in retroperitoneal panniculitis.


Primary spindle-cell sarcoma of the spleen with angiographic demonstration.


Electronic radiography for spot-filming in gastrointestinal fluoroscopy.


Lymphofollicular synovitis with osteoid osteoma.


Bone mineral measurement by means of photon absorption.


Caveat on use of the parameter d' for evaluation of observer performance.


Anomalous branches of the internal cartoid artery.


Macroaggregated RISA lung scan in congenital heart disease.


Perfusion lung scan in normal volunteers.


Adjunctive brain scanning with  67 Ga in metastases.


Recovery and reconcentration of radioactive gases from the cryogenic trap.


Mental retardation following in utero exposure to the atomic bombs of Hiroshima and Nagasaki.


Sarcoidosis in children.

Sarcoidosis in children.


Angiographic exposure timing by Doppler-shift ultrasound.


Association of hemoglobin levels before and during radiotherapy with prognosis in uterine cervix cancer.


Effect of cobalt-60 irradiation upon cell-mediated immunity.


A comparison of tungsten and molybdenum as target material for mammographic x-ray tubes.


Effect of inhaling oxygen-carbon dioxide mixtures on oxygenation and cure by x-rays of C3HBA mouse mammary carcinoma.


Factors affecting hypoxic KHT tumor cells in mice breathing  O2, O2 + CO2 , or hyperbaric oxygen with or without anesthesia.


Effect of epsilon-amino-n-caproic acid (EACA) on radiation-induced increase in capillary permeability.


Repair of potentially lethal radiation damage in vitro and in vivo.


A graphic means of estimating the perfusion rate rapidly from xenon washout curves.


Accuracy in stereoscintiphotography of the brain.


Effects of single dose and of fractionated radiation on rabbit bone marrow.


Angiographic catheters for tracheobronchial procedures in infants and children.


Deflector method for nonsurgical removal of knotted catheters.


Patient positioning device for external-beam radiation therapy of the head and neck.


The Radiological Society of North America, Inc.


The Inter-American College of Radiology.


Statement issued by the International Commission on Radiological Protection after its meeting in November 1972.


The effect of surgical trauma on the conjugation pattern of 17-hydroxycorticosteroids.


A technique for intestinal decompression: sodium loss in intestinal obstruction.


Blood vessel invasion and lymph node metastasis: two factors affecting survival in breast cancer.


Limb arteriovenous shunting following sympathetic denervation.


Respiratory insufficiency in patients with severe head injury.


Intraoperative decompression of the obstructed small bowel.


Primary pharyngogastrostomy for carcinoma of the esophagus situated in the cervicothoracic segment.


Small vessel occlusion in the extremity after various periods of arterial obstruction: an experimental study.


The aberrant divisional bile duct: a surgical hazard.


A prospective randomized study of the elective surgical treatment for duodenal ulcer: two-to-ten-year follow-up study.


An evaluation of wound complications after neck dissection and composite resection utilizing transverse cervical incisions.


Septum reformation: a complication of the Duhamel procedure.


The effect of dietary cholesterol on the composition of human bile.


Visualization of isolated retained antrum by using technetium-99m.


Review of 220 cases of residual biliary tract calculi treated without reoperation: an eight-year study.


Prolonged use of a membrane oxygenator in air-breathing and hypoxic lambs. I. Venovenous bypass.


Regional resection for pancreatic carcinoma.


Disseminated intravascular coagulation.

Disseminated intravascular coagulation.


Drug interactions.

Drug interactions.


Treatment of duodenal ulcer.

Treatment of duodenal ulcer.


Medullary carcinoma of the thyroid.

Medullary carcinoma of the thyroid.


Neuropathic joint disease.

Neuropathic joint disease.


Cardiopulmonary resuscitation.

Cardiopulmonary resuscitation.


Mechanisms of teratogenesis.

Mechanisms of teratogenesis.


Duration of the cycle of the seminiferous epithelium and the spermatogonial renewal in the monkey Macaca arctoides.


Morphological variations of pigment granules in eyes of the Rhesus monkey.


Presence of biogenic amines in early rat development.


The relationship between jaw, arm and leg size in three ethnic groups.


Ecological investigation of vertebrate hosts of Venezuelan equine encephalomyelitis virus in south Florida.


Considerations on the ecology of several arboviruses in eastern Long Island.


Dengue virus transmission by Aedes aegypti mosquitoes following intrathoracic inoculation.


Urticaria caused by tarantula hairs.

Urticaria caused by tarantula hairs.


The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice.


Experiences in the therapy of amebic liver abscess on Taiwan.


Balantidiasis outbreak in Truk.

Balantidiasis outbreak in Truk.


Susceptibility to Brugia pahangi in geographic strains of Aedes aegypti.


Comparative study of pyrantel pamoate, bephenium hydroxynaphthoate, and tetrachloroethylene in the treatment of Necator americanus infections.


A non-fatal human case of Powassan virus encephalitis.


Silicone elastomer implantation cyclodialysis. A negative report.


Radionuclide arteriography in ophthalmology.


Shall we count numbers of eyes or numbers of subjects?


Kappa angle measures of strabismic and nonstrabismic individuals.


Proteinaceous corneal degeneration. A histochemical study.


Electronystagmography.

Electronystagmography.


Cholinesterases and contractility of cat irides. Effect of echothiophate iodide.


A versatile color confrontation test for the central visual field. A comparison with quantitative perimetry.


Role of ventilating tubes in tympanoplasty.


Middle fossa eustachian tuboplasty.

Middle fossa eustachian tuboplasty.


Tympanometry for Eustachian tube evaluation.


Tympanomaxillary shunt.

Tympanomaxillary shunt.


Anatomy of the eustachian tube.

Anatomy of the eustachian tube.


Diagnosis and treatment of cochlear otosclerosis.


Incidence and management of complications of stapes surgery.


Experiences with tympanic transplants.

Experiences with tympanic transplants.


Squamous carcinoma of the ear.

Squamous carcinoma of the ear.


Reconstruction of the mastoidectized ear.


Tympanic transplants.

Tympanic transplants.


Vestibular tests for the clinician.

Vestibular tests for the clinician.


Head injury. Some otoneurologic sequelae.


Whiplash with vestibular involvement.

Whiplash with vestibular involvement.


Updating special hearing tests in otological diagnosis.


Clinical application of special hearing tests.


Cortical evoked responses in neuro-otologic diagnosis.


Physiology of the eustachian tube.

Physiology of the eustachian tube.


Cytokinetics of the S-180 ascites tumor system.


Stimulation of DNA synthesis by isoproterenol in rat submandibular gland during postnatal growth.


Hydroxyurea effects in the C3H mouse. II. Mammary tumor cell kinetics.


Local and systemic control of granuloctic and macrophage progenitor cell regeneration after irradiation.


Properties of haemopoietic stem cells in phenylhydrazine treated mice.


Jeopardized, blighted, and necrotic myocardium.


Venography.

Venography.


Inability of the submaximal treadmill stress test to predict the location of coronary disease.


Significance of high degree atrioventricular block in acute posterior myocardial infarction. The importance of clinical setting and mechanism of block.


The importance of identification of the myocardial-specific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction.


Systemic arterial disease with myocardial infarction. Report on two infants.


Influence of direct myocardial revascularization on left ventricular asynergy and function in patients with coronary heart disease. With and without previous myocardial infarction.


Thirty-month follow-up of maximal treadmill stress test and double Master's test in normal subjects.


Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation.


Ventriculographic patterns and hemodynamics in primary myocardial disease.


Light-pen computer processing of video image for the determination of left ventricular volume.


Intravascular platelet aggregation in the heart induced by stress.


Type I, type II, and type 3 gaps in bundle-branch conduction.


Absence of anatomic origin from heart of pulmonary arterial supply.


Racial frequencies in congenital heart disease.


Atropine and acute myocardial infarction.


Echocardiographic pattern of right ventricular diastolic volume overload in children.


Wolff-Parkinson-White syndrome.

Wolff-Parkinson-White syndrome.


Histochemical study of ubiquinones in the central nuclei of the cerebellum of the mouse during its development.


The influence of thyroid hormone on rat colonic temperature during exercise.


Morphological and cytochemical modifications induced by colchicine treatment in the duodenal epithelium of mouse.


Muscle glycogen consumption during cross-country skiing (the Vasa ski race).


Behavior therapy in treating obesity.

Behavior therapy in treating obesity.


In defense of body weight.

In defense of body weight.


Behavior modification in a self-help group.


Behavioral and metabolic consequences of weight reduction.


Physiologic control of food intake.

Physiologic control of food intake.


Inclusion of cellulose in calorie-restricted diets. Effect on body composition, nitrogen balance, and cholesterol levels in obese rats.


Clinical research diets: definition of terms.


Muffins and pastry made with medium-chain triglyceride oil.


Counterconditioning versus forced exposure in extinction of avoidance responding and conditioned fear in rats.


A multidimensional experiment. Synthesis of a sulfa drug and its use as a chemotherapeutic agent.


Effect of US habituation following conditioning.


Pavlovian analysis of avoidance conditioning in the goldfish (Carassius auratus).


US duration, conditioned acceleration, multiple CR measurement, and Pavlovian R-R laws in rats.


Conditioned vocalization in rats.

Conditioned vocalization in rats.


Refractory periods of neurons directly excited in stimulus-bound eating and drinking in the rat.


Plasma-corticosterone levels during active-avoidance learning in rats.


Behavioral responsiveness of adrenalectomized, hypophysectomized, and intact rats to electric shock.


Decrease in food intake following cortical spreading depression in static obese rats with ventromedial hypothalamic lesions.


Sodium appetite in adrenalectomized rats following dietary sodium deprivation.


Recent advances in the pathogenesis of renal calculi.


Reanalysis of feeding patterns in the rat.


A flow-sheet for use in renal stone disease.


The state and the medical profession in Europe.


Atrial myxoma.

Atrial myxoma.


Management of ureteric calculi: a review of 500 cases.


Medullary sponge kidney: review of the literature and presentation of 33 cases.


Strangulation of appendages by hair and thread.


Absence of musculature of the distal ileum: a cause of neonatal intestinal obstruction.


Right-lower-lobe pneumonia and acute appendicitis in childhood: a therapeutic disorder.


Intussusception in Rhodesian Africans: a contrast with the accepted clinical picture.


Bilateral teratoma of testis in an infant.


Severe cyclophosphamide hemorrhagic cystitis controlled with phenol.


Successful treatment of neonatal retroperitoneal hemangioma with corticosteroid.


Asplenia and lethal pneumococcal septicemia following supradiaphragmatic splenic transposition for Chiari's disease.


The crescent sign and hydronephrosis.

The crescent sign and hydronephrosis.


Pseudocyst of the pancreas secondary to gastric duplication.


Choledochal cyst: diagnosis by oral cholecystography.


Median ectopic thyroid gland.

Median ectopic thyroid gland.


Studies on the preservation of canine lung at subzero temperatures.


Membranous esophageal obstruction simulating atresia with a double tracheoesophageal fistula in a neonate.


Regeneration of the lung in the dog.

Regeneration of the lung in the dog.


Hemodynamics of venous repair in the canine hind limb.


Herniation of the heart after pneumonectomy.


Chondrosarcoma of the trachea. Report of a case and five-year follow-up.


Mediastinal tumors. Review of 186 cases.


Laryngotracheoesophageal cleft associated with esophageal atresia and multiple tracheoesophageal fistulas in a twin.


Sternal osteomyelitis and costochondritis after median sternotomy.