Strychnine- and pentylenetetrazol-induced changes of excitability in Aplysia neurons.


Ovarian carcinoma--a 10-year series from a provincial hospital.


Radioisotope renography in the surgical management of carcinoma of the cervix.


Continuous recording of uteroplacental blood volume in the human.


Diazepam (Valium) as an anaesthetic for operative vaginal delivery.


A method of measuring the interspinous diameter by an ultrasonic technique. A preliminary report.


The transfer of diazepam across the placenta during labour.


The effect of oxygen ventilation and a vasodilator on uterine perfusion, foetal oxygen and acid-base balance. I. A study in healthy gravidae.


Toxaemia and cigarette smoking during pregnancy. Prospective consecutive investigation of 3,927 pregnancies.


The Anker dilator in therapeutic abortion.


Fertility of donors at heterologous insemination.


Natural history of combined right bundle branch block and left anterior hemiblock (bilateral bundle branch block).


Cholelithiasis in sickle cell anemia in a Caucasian population.


Symptomatic normovolemic essential hypernatremia. A clinical and physiologic study.


The Wilton Marion Krogman Center for Research in Child Growth and Development.


Postobstructive diuresis. Studies in a dialyzed patient with a solitary kidney.


Ketamine and the pregnant uterus.

Ketamine and the pregnant uterus.


Some problems associated with measurement of physiological blood gases.


Site of action of diazepam in the prevention of lidocaine induced seizure activity in cats.


A comparison of the effects of two haemodiluents on monovalent and divalentcations in children undergoing cardiopulmonary bypass and open-heart surgery.


Succinylcholine induced hyperkalaemia in patients with strabismus.


Autoregulation of renal blood flow: alteration by methoxyflurane.


Althesin--a new intravenous anaesthetic.


Measurement of mucociliary clearance from the lower respiratory tract of normal dogs.


Cleaning the laryngoscope blade.

Cleaning the laryngoscope blade.


Protection of gilts against leptospirosis by use of a live vaccine.


Bilateral subcostal laparotomy for the correction of a diaphragmatic hernia.


Haemobartonellosis in a dog in Saskatchewan.


The veterinarian in community health.

The veterinarian in community health.


Iatrogenic diseases related to the treatment of respiratory distress in the neonatal period. Radiological diagnosis. I. Pleuro-pulmonary lesions.


A critique of methods in reported studies of long-term vascular complications in patients with diabetes mellitus.


Dietary diabetes. The influence of a low carbohydrate diet on forearm metabolism in man.


Effect of phenformin on water and glucose transport across isolated human ileum.


Do the oral and intravenous glucose tolerance tests provide similar diagnostic information in patients with chemical diabetes mellitus?


Failure of induction of liver microsomal enzymes by tolbutamide in maturity-onset diabetics.


Complications of colonic and rectal surgery: perioperative respiratory problems.


Complications of colonic and rectal surgery: discussion.


Complications of colonic and rectal surgery: results of a study of early presumptive antimicrobial therapy of serious infections in surgical patients with intestinal diseases.


Is colostomy a necessary complement to elective left colonic resection?


Complications of colonic and rectal surgery: infections, incidental and acquired, and their treatment.


Herniation of the cecum through the foramen of Winslow: radiographic diagnosis and report of a case.


The effects of electrosurgery and the surgical knife on the healing of intestinal anastomoses.


The relaxed perineum and anorectal disease revisited.


Complications of colonic and rectal surgery: the causes and management of postoperative urologic complications.


Squamous-cell carcinoma of the anus.

Squamous-cell carcinoma of the anus.


A model for exploring intra- and interindividual process in groups.


A group member's suicide: treating collective trauma.


Group therapy with faminine boys and their parents.


Group treatment of the mother-daughter relationship.


Interaction of group cotherapists in the multidisciplinary team treatment of obesity.


Some practical and empirical aspects of group approaches in psychiatric facilities: epilogue on a therapeutic community.


Ab initio calculations on large molecules using molecular fragments. Model peptide studies.


Long-term health effects of dietary monosodium glutamate.


Antibodies specific for conformationally distinct coenzyme-substrate transition state analogs. A fluorescence, nuclear magnetic resonance, circular dichroism, and antibody study of N-(5-phosphopyridoxyl)-3'-amino-L-tyrosine.


Nucleosides. LXXIX. Facile base-catalyzed hydrogen isotope labeling at position 6 of pyrimidine nucleosides.


Binding of cis- and trans-dichlorodiammineplatinum(II) to nucleosides. I. Location of the binding sites.


Bromide ion probe nuclear magnetic resonance studies of protein conformation. Application to methemoglobin.


Subtilisin catalysis of nonspecific anilide hydrolyses.


A new rhodium(I)-porphyrin complex. II. Synthesis and oxidative alkylation.


Averufin in the biosynthesis of aflatoxin B.


Total synthesis of prostaglandins. IV. A completely stereospecific synthesis of prostaglandin E.


Electron nuclear double resonance of bacteriochlorophyll free radical in vitro and in vivo.


Nuclear magnetic resonance studies of a polypeptide in a nonprotonating solvent system.


Occult spontaneous rupture of the spleen: a diagnostic problem.


On the evils of drink. Some observations--clinical and personal.


A direct method for cobalt-carbon bond formation in cobalt(3)-containing cobalamins and cobaloximes. Further support for cobalt(3). Complexes in coenzyme B 12  dependent rearrangements.


Some relationships between teacher morale and teacher behavior.


Memory for sequence, form, and position as related to the identification of reading retardates.


Role of instructions and reinforcement in behavior changes in token reinforcement programs.


Relationship between the internal-external control construct and achievement.


Lymphocyte transformation induced by autologous cells. II. Stimulation by mitogen-induced lymphoblasts. Lymphocytes incubated with phytohemagglutinin or concanavalin A develop the capacity to stimulate autologous lymphocyte transformation. This is not attributable to residual mitogen contaminating the lymphoblastic cell preparation as: (a) the dissociation of mitogen from the lymphoblastic cell preparation increases the degree of stimulation observed and (b) the kinetics of lymphocyte transformation stimulated by phytohemagglutinin-induced lymphoblasts is different from that stimulated by phytohemagglutinin. The appearance of the stimulatory determinants on lymphocytes exposed to phytohemagglutinin precedes morphological transformation.


A major genetic locus affecting resistance to infection with murine leukemia viruses. 3. Assignment of the Fv-1 locus to linkage group 8 of the mouse. The Fv-1 gene, which regulates sensitivity of mouse cells to infection by naturally occurring host-range types of murine leukemia virus, was shown to be located on linkage group VIII (chromosome 4), 39 map units from b.


The early recognition of scoliosis.

The early recognition of scoliosis.


Continuing professional education.

Continuing professional education.


Sustained isometric handgrip--a useful bedside maneuver.


The least of it.

The least of it.


Psychiatric dangers in running for political office.


Disease, the host defense, and Q-10.

Disease, the host defense, and Q-10.


A short hystery of conception.

A short hystery of conception.


Political priorities and controls: implications for medical schools.


Capillary endothelium and data processing: a hypothesis.


The doctor as an organization man.

The doctor as an organization man.


How much is basic research worth really?


Diabetes mellitus as analogue of pernicious anemia: a speculation.


Pyridoxol biosynthesis by Saccharomyces fragilis.


In vitro preparation of a growth factor from plerocercoids of the tapeworm, Spirometra mansonoides.


A new radioisotopic microassay of cell-mediated immunity utilizing technetium-99m labeled target cells.


Effects of prostaglandins E 1  and F 2   on the peripheral circulation in the cat.


Absorption of liver folates from small intestinal segments of the rat.


Influence of the frequency and route of injection of HCG and FSH antisera on their gonadotropic and progonadotropic responses.


Elevated levels of serum  -acetylglucosaminidase in some patients with rheumatoid arthritis.


Inhibition by ATP of erythrocyte glucose-6-phosphate dehydrogenase.


Plasma and cardiac lactic dehydrogenase activity in burn shock.


Dopamine generated from L-dopa: discrepancy between plasma levels and cardiac effects.


Stimulation of DNA synthesis in rat kidney by repeated administration of lead.


Metabolism, in the rat, of biotin injected intraperitoneally as the avidin-biotin complex.


Comparative effects of aliphatic alcohols on the gastric mucosa.


Degradation of neurohypophyseal hormones by brain extracts and purified brain enzymes.


Calcium stimulation of uridine-6- 3 H incorporation into RNA of rat myocardium.


Zinc metabolism and homeostasis in ruminants as affected by dietary energy intake and growth rate.


Effect of 6-MP and 6-MP-palladium complex on serum uric acid levels in the chick.


Effect of copper on red cell glutathione and enzyme levels in high and low glutathione sheep.


Effects on lactation of progesterone injections administered before and after parturition in the rat.


Growth hormonal activity of thyrotropic pituitary tumors.


Chronic glucagon administration enhances intestinal transport in the rat.


Mitotic activity and cell number of denervated parotid of adult rat.


Incidence of Friend virus-induced polycythemia in splenectomized mice.


Radiation-resistant thymic stem cells.

Radiation-resistant thymic stem cells.


Erythrocyte osmotic fragility in the presence of lead or mercury.


Hexachlorophene-induced alterations in the metabolism of cultured human lung cells.


Erythrocyte enigmas in cystic fibrosis.

Erythrocyte enigmas in cystic fibrosis.


3-Methyl glucose transport in isolated epithelial cells from rat small intestine.


The procoagulant activity of granulocytes.


Tissue distribution of radioiodinated human growth hormone in the mouse.


Relation between growth of carcinogen-induced mammary cancers and serum prolactin values in rats.


Intramuscular triglyceride utilization by red, white, and intermediate skeletal muscle and heart during exhausting exercise.


Effects of postnatal maturation and castration on rat epididymal carbohydrate metabolism.


Accelerated transport of  -aminoisobutyric acid in kidney during compensatory hypertrophy.


The turnover of rat-liver folate pools.

The turnover of rat-liver folate pools.


Urinary excretion of biotin and metabolites in the rat.


Rapid increase in nuclear hydrolase following partial hepatectomy in the rat.


Effect of ethanol consumption on lipid metabolism in the Buffalo rat.


Effect of exogenous steroids and inhibitors of steroidogenesis on endotoxin shock.


Activation of mouse spleen cells with acetylated concanavalin coupled to red blood cell stroma.


Charge and ion-binding differences between corneal epithelial and endothelial antigens.


The requirement of cortisol for the inhibitory effect of norepinephrine on the antidiuretic action of vasopressin.


Female pattern of metabolism of (4 14 C)corticosterone in male pseudohermaphroditic rats.


Regional dynamic behavior of the total right ventricle.


Glucose reabsorption in the newborn dog kidney.


Filaments and microtubules in the cytoplasm of the granulosa cells from the human follicle.


Swelling of mitochondria in crayfish gills.


The inhibition of kohlrabi chloroplast degeneration by kinetin.


Mechanism of the light-dependent accumulation of starch in chloroplasts of Acetabularia, and its regulation.


Development of Woronin bodies from microbodies in Fusarium oxysporum f.sp. lycopersici.


The radiology of the normal anterior fontanelle.


Value of the routine use of the cerebral dynamic radioisotope study.


Clinical evaluation of orally administered fluorine 18 for bone scanning.


Effects of corticosteroid (dexamethasone) administration on the brain scan.


The autonamous thyroid nodule: correlation of scan appearance and histopathology.


Left atrial volume, shape, and movement in total anomalous pulmonary venous return.


Humeral-head and coracoid ossification in the newborn.


Powdered tantalum as a contrast agent for tracheobronchography in the pediatric patient.


Herniation of the nucleus pulposus. A rare complication of intervertebral-disk calcification in children.


Spontaneous osteonecrosis of the knee.

Spontaneous osteonecrosis of the knee.


The bobble-head doll syndrome. A curable entity.


Ciné ultrasound cardiography.

Ciné ultrasound cardiography.


Demonstration of transposition of the great arteries by cardiac ultrasonography.


Low dose radiation therapy and combination chemotherapy in the treatment of advanced Hodgkin's disease.


Splenectomy and hematologic tolerance to irradiation in Hodgkin's disease.


Prognostic factors and the importance of radiation therapy in infradiaphragmatic non-Hodgkin's lymphoma.


Protective barriers about diagnostic x-ray installations.


Black-and-white slides by the template process.


Xeroradiography of the lung.

Xeroradiography of the lung.


Arteriographic findings in patients with degenerative osteoarthritis of the hip.


Ciné coder.

Ciné coder.


Giant bone islands.

Giant bone islands.


Silicone rubber arthroplasties of the hand.


Abdominal angiography: acid-base balance.


Renal angiography in sickle-cell disease. A preliminary report correlating the angiographic and urographic changes in sickle-cell nephropathy.


The "inverted V": a new sign of pneumoperitoneum.


Unusual roentgen manifestations of bronchogenic cysts.


Treatment of lung abscess by transbronchial catheter drainage.


Roentgenographic manifestations of pulmonary calcifications. A rare cause of respiratory failure in chronic renal disease.


Radiographic manifestations of primary acquired hypogammaglobulinemia.


Bursting forces within the human body.

Bursting forces within the human body.


Cystic duct remnant-duodenal fistula.

Cystic duct remnant-duodenal fistula.


Evaluation of three-dimensional radiography in clinical radiology.


A new cranial suture appearing in the site of craniectomy for synostosis.


The narrow lumbar spinal canal syndrome.


Effect of acute exposure to CO 2  on lung mechanics in normal man.


Mechanics of breathing in high altitude and sea level subjects.


Comparison of blood and alveolar gas composition during rebreathing in the dog lung.


Studies on alveolar-mixed venous CO 2  and O 2  gradients in the rebreathing dog lung.


Vital capacity breaths of 5 percent or 15 percent CO 2  in N 2  or O 2  to test carotid chemosensitivity.


Role of the arterial chemoreceptors in ventilatory adaptation to hypoxia of awake dogs and rabbits.


Cardio-respiratory responses to carotid body stimulation with NaCN in the chicken.


Phrenic nerve response to passive muscle stretch at different arterial CO 2  tensions.


Respiratory responses of the anesthetized rabbit to vagotomy and thoracic dorsal rhizotomy.


The oxygen deficit and debt for normal and non-athletic men.


Oxygen affinity of blood in rats during chronic anemia and after its correction.


Seat reaction direction in an animal centrifuge.


Effect of a helium-oxygen atmosphere on the developing chick embryo and subsequent growth of chicks.


Human endocrine-metabolic responses to graded oxygen pressures.


Disorienting effects of aircraft catapult launchings.


Seizures, H 2 O 2  formation and lipid peroxides in brain during exposure to oxygen under high pressure.


Nitrogen, helium, and neon effects on timing behavior at increased pressures.


Thermal protective garment using independent regional control of coolant temperature.


Hyperbarism and reproduction. II. The conception rate of mice under different hyperbaric conditions.


Effects of high pressure on alpha and beta adrenergic receptors of the rabbit duodenum.


Effect of methemoglobin on in vivo RBC lipid peroxidation.


Modulated light transmission for electrical isolation in a multichannel physiological monitoring system.


Civil aviation medicine in the coming decade.


Five year study of general aviation physical examinations.


Postmortem alcohol analyses of general aviation pilot fatalities, Armed Forces Institute of Pathology, 1962-1967.


Man-machine interface: a study of injuries incurred during ejection from U. S. Navy aircraft.


Military public health nurse program at David Grant USAF Medical Center.


Predictions of the dynamic response of the lung.


Observations on perceived changes in aircraft attitude attending head movements made in a 2-g bank and turn.


Electrocardiographic diagnosis of pacemaker catheter displacement.


Analysis of the P wave in congenital cardiac malformations associated with splenic anomalies.


Systolic venous reflux sounds.

Systolic venous reflux sounds.


Two types of ventricular septal defect in corrected transposition of the great arteries: reference to surgical approaches.


Effects of acute right ventricular systolic hypertension on regional myocardial blood flow in anesthetized dogs.


Digitalis toxicity. Development of cardiac arrhythmias in spontaneously breathing vs. artificially respired dogs.


The effects of maternally administered digoxin upon the cardiovascular hemodynamics of the fetal lamb.


Simulation of measured activation sequence in the human heart.


Venous thrombosis and permanent cardiac pacing.


Mental mechanisms and the pain of angina pectoris.


Total body potassium changes with prolonged diuretic therapy.


A new symbol for the equilateral tetrahedral reference frame.


Therapeutic myocardial digoxin concentrations.


Varicose veins, deep vein thrombosis, and hemorrhoids.


Fatty acids and sudden death.

Fatty acids and sudden death.


Acute and chronic effects of intraperitoneal injection of two types of asbestos in rats with a study of the histopathogenesis and ultrastructure of resulting mesotheliomas. Malignant mesotheliomas were induced in the rat peritoneum by a single injection of chrysotile or crocidolite asbestos fibers. The immediate toxicity of the fibers was noted in both groups of animals, producing approximately 40% mortality, within 8 days after the injection associated with acute peritonities. Tissue reactions to these two types of asbestos were significantly different. Crocidolite fibers were easily seen by light microscopy, in the tissue sections throughout the period of study, and they produced foreign-body giant cell granulomas. However, giant cells were not seen in chrysotile granulomas, and the asbestos fibers were only seen by electron microscopic study. They appeared to be coated by a protein-like substance. During earlier stages of tumorigenesis, the epithelioid and/or mixed cell type mesotheliomas seemed to have no specific relationship to granulomas, but pure spindle cell tumors were seen to develop in close relationship to granulomas, and they appear to be fibrosarcomas. Electron microscopic and histochemical methods were used to define the morphologic characteristics of the tumor cells. The formation of hyaluronic acid was found in cells of the epithelioid type, contrasted with extracellular accumulation in the spindle cell tumors.


Freeze-etch observations on the plasma membrane and other structures of normal and abnormal platelets. Human platelets in plasma were subjected to freeze fracture followed by etching. The outer surface of the platelet plasma membrane was exposed by etching but not by fracturing and was clearly identified by use of latex particles as markers. Surface-associated particles, apparently embedded in the plasma membrane, were found to measure from 83 to 332 A in diameter. Similar particles were associated with membranes lining the surface-connected canalicular system and with limiting membranes of storage granules. Fortuitous fractures exposed two inner faces of the plasma membrane, one of which contained greater numbers of surface-associated particles than did the outer surface of the plasma membrane. The second inner face of the plasma membrane contained numerous fibrillar structures measuring up to 770 A in length. Platelets from a congenitally afibrinogenemic patient appeared normal when examined by freeze-etch technics. Normal platelets exposed to a potent antiaggregating agent (REM 10,393) were found to have lost most of the particles associated with the outer surface of the plasma membrane and to have developed numerous defects in this membrane. A possible role for surface associated particles in platelet aggregation was further suggested by the finding that the nonaggregable platelets of two congenitally thrombasthenic sisters were nearly devoid of these structures.


The rehabmobile: a mobile rehabilitation clinic in an urban ghetto area.


Rehabilitation medicine revisited.

Rehabilitation medicine revisited.


Intermittent catheterization in patients previously on indwelling catheter drainage.


The stroke registry: a prospective method of studying stroke.


Facilitation technique usage.

Facilitation technique usage.


Exercise programs for health maintenance: an opportunity for rehabilitation medicine.


Force measurement device for canes and crutches.


Consumerism and rehabilitation medicine.


Tattoo removal. A new simple technique.

Tattoo removal. A new simple technique. Table salt applied by salabrasion, tattooing or dermabrasion was used in the treatment of unwanted tattoos in 25 cases. With removal of the eschar at the treated site, the unwanted pigmentation was reduced by half, and there was further dimming to virtual disappearance during further healing.


Arsenic poisoning.

Arsenic poisoning. These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. David W. Martin, Jr., Assistant Professor of Medicine, and Kenneth A. Woeber, Associate Professor of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine. Requests for reprints should be sent to the Department of Medicine, University of California, San Francisco, San Francisco, Ca. 94122.


Case reports. Diffuse skeletal and hepatic hemangiomatosis.


Malfunction of a colostomy in a patient with Crohn's disease.


More on abortion.

More on abortion.


Telepede. A new continuing education service for the practitioner.


Health services in Saskatchewan. North America's first comprehensive government-sponsored health plan.


National surgical breast project.

National surgical breast project. For public and professional acceptance, clinical studies in breast cancer must be scientifically necessary and ethically justifiable. To resolve controversy based upon retrospective data, they must be prospective and randomized. These guidelines have been used by the National Surgical Adjuvant Breast Project in its investigations carried out during the past 15 years in numerous cooperating institutions. Neither thio-tepa adjuvant to radical mastectomy, nor prophylactic oophorectomy, nor post-operative radiation therapy were found to prolong life. Therefore, prophylactic oophorectomy is contraindicated and adjuvant chemotherapy cannot be justified except perhaps under special circumstances and as part of carefully controlled clinical trials. Postoperative radiation therapy, even in the presence of positive axillary lymph nodes, cannot be recommended except to minimize the rate of local skin recurrences.The present study addresses itself to the timely controversy surrounding proper management of axillary lymph nodes in primary breast cancer. Does removing them alter the outcome of therapy? Total (simple) mastectomy is being compared with radical mastectomy. Women with clinically negative nodes on physical examination are treated either by total (simple) mastectomy alone or by total mastectomy plus radiation, or by radical mastectomy. When the nodes are clinically positive, either radical mastectomy or total mastectomy followed by radiation is being used.The protocol, now underway more than a year, has been well accepted by patients and by many well informed physicians and surgeons. In years ahead it will provide objective evidence as to whether or not removal of the axillary lymph nodes alters the therapeutic efficacy of mastectomy in the treatment of primary breast cancer.


A "second generation" stilbestrol alert. A memo to physicians of California from the CMA Committee on Pharmacy and Therapeutics.


Treatment of cardiogenic shock. II.

Treatment of cardiogenic shock. II.


Levodopa in Forbes-Albright syndrome.

Levodopa in Forbes-Albright syndrome.


Care of the aged.

Care of the aged.


Duodenoscopy in the diagnosis of upper gastrointestinal disease. Duodenoscopy was undertaken in 143 patients with upper gastrointestinal tract symptoms. There were no complications of the procedure. The duodenum was successfully entered in 98% of attempts, and in 90% of patients the examination was judged to be technically successful. When compared with radiological assessment, the findings at duodenoscopy significantly altered diagnosis and management in 21% of patients. The endoscopic appearance of the non-ulcerated duodenal mucosa could not be consistently correlated with changes found in biopsy tissue obtained under direct vision. Duodenoscopy is a valuable adjunct in the clinical assessment of upper gastrointestinal tract symptoms suspected to be due to pathological changes in the duodenum.


An agricultural accident survey in Alberta, 1970.


Frequency of hepatitis B antigen in blood donors. Routine testing of all blood donations for hepatitis B antigen by counter-immunoelectrophoresis was started in April 1971. The frequency of HBAg carriers among apparently healthy volunteer blood donors in the Toronto Centre of the Canadian Red Cross Blood Transfusion Service was 15 in 10,000 with a male:female ratio of 6:1. Excluding penitentiary inmates, the highest incidence was among young, male, non-Anglo-Saxon city dwellers.A system of notification of HBAg-positive donors was developed, through which a carrier is referred to a special clinic for clinical and pathological evaluation.A survey of hospital patients indicated an incidence of HB antigen 3.5 times that of our healthy donor population. A comparison of the number of post-transfusion hepatitis cases occurring before and after the commencement of routine testing for HBAg showed a marked reduction in reported cases in 1971.


Community psychiatry and the elderly.

Community psychiatry and the elderly. An account is given of the first year's experience in providing psychogeriatric service to a large urban community. Patients were attended in their homes, in nursing homes and in Homes for the Aged. There was a tendency for the consultant's help to be sought mainly in cases of "disposal" of difficult patients rather than for treatment of the many who could be expected to benefit from it. However, the advantage has been demonstrated of continuity of service in the variety of settings and, as a result, the more proper placement of patients. Acceptance of the help the psychogeriatrician can contribute will inevitably increase, but demands the provision of improved day-care and day-hospital facilities.


Pregnancy loss among British Columbia mothers.


Measuring the impact of a district health unit--a baseline study.


An approach to the detection and management of early breast cancer. The mortality rate for breast cancer has not changed for 40 years. The ultimate results using the various surgical techniques differ very little. Local tumour excision produces survival rates comparable with those for more radical operations. Ideal treatment should give optimal quality and quantity of survival with minimal trauma. Survival is mainly determined by the ability to live in symbiosis with the disease and in most cases clinically obvious tumours are already incurable. Clinical examination alone will not detect disease at a stage early enough for more effective treatment. Mammography and thermography can detect occult breast cancer and, in particular, thermography can be used for serial examinations in high-risk patients because the procedure is simple and without hazard.


Imported sparganosis in Canada.

Imported sparganosis in Canada. The first case of human sparganosis in Canada is reported in a 23-year-old woman who emigrated from Greece in 1969. Examination of a ribbon-like worm removed from a painful swelling in the neighbourhood of her right biceps muscle revealed a single larva, about 110 mm. long and 2.5 mm. wide, subsequently identified as the plerocercoid larva or sparganum of a member of the genus Spirometra. The source of this infection, acquired in Greece, may have been undercooked pork.


Prescription for updating hospital outpatient departments.


Public seems ripe for a little heresy in treatment. But can it be controlled?


Nova Scotia health council report urges ways to improve health care.


Health of Indians on the Hudson's Bay railway.


The frequency of intracranial neoplasms in Newfoundland.


The individual readiness and diagnostic test: its use in predicting academic success and diagnosing learning problems in conjunction with beginners' clinics.


Health manpower development in Canada.

Health manpower development in Canada.


Supervision: the challenge of the new student.


Effects of prolactin and thyroxine in hypophysectomized and thyroidectomized red efts of the newt Notophthalmus (Diemictylus) viridescens.


EEG seizure patterns during multiple unilateral and bilateral ECT.


The effectiveness of different learning experiences for teaching psychiatry.


The effect on the gonadal axis in cockerels of electrolytic lesions in various regions of the basal hypothalamus.


Effects of gonadectomy and replacement therapy on adrenal function in the domestic duck, Anas platyrhynchos.


Effect of hypophysectomy on renal function in the freshwater North American eel (Anguilla rostrata LeSueur).


Current Adlerian therapies.

Current Adlerian therapies.


The medical model in psychoanalysis and psychotherapy.


Research in geriatric psychiatry and the care of the aged.


Casualties of the antismoking campaign.

Casualties of the antismoking campaign.


Changes in the plasma volume ( 125 I-serum albumin label) and the total circulating erythrocyte mass ( 51 CrO 4  label) in Japanese quail treated with stilbestrol or with testosterone.


Metabolic effects of epinephrine and norepinephrine in the eel Anguilla anguilla L.


Biochemical data on some organs from normal or prolactin-treated Xenopus laevis (Daudin) adults reared in fresh and in salt water.


Endocrine control of clutch size in reptiles. I. Effects of FSH on ovarian follicular size-gradation in Leiolopisma laterale and Anolis carolinensis.


Evidence for an intrinsic gonadotropic activity of ovine LH in the lizard.


No exit: the persistently suicidal patient.


Thyroxine secretion rates in desert lizards: Dipsosaurus dorsalis and callisaurus draconoides.


The regulation of ovary function in Cirratulus cirratus (polychaeta).


Bioassay of thyrotropin in chicks with simultaneous estimation of gonadotropin.


Seasonal variation in LH and FSH of bilaterally castrated snowshoe hares.


Effects of corticosteroids on liver transaminases in two salmonids, the rainbow trout (Salmo gairdnerii) and the brook trout (Salvelinus fontinalis).


FSH and LH in the snowshoe hare during the increasing phase of the 10-year cycle.


Recovery of gonadal function following hypothalamic lesions in Japanese quail.


A fine structural and histochemical study of the Leydig cell in the testis of the teleost, Oryzias latipes (Cyprinidontiformes).


An evaluation of the alkali flame ionisation detector and the Coulson electrolytic conductivity detector in the analysis of N-nitrosamines in foods.


Metabolism of diethylhexyl phthalate by rats. Isolation and characterization of the urinary metabolites.


A simple ion-exchange chromatographic procedure for the analysis of the major ribo- and deoxyribonucleotides.


Micro-chromatographic and radiochemical analysis of glycopeptides.


The separation of bile acids from neutral lipids by thin-layer chromatography.


Mapping and specific detection of glycopeptides on thin-layer plates.


Specific gas chromatographic determination of xanthines and barbiturates by flash-heater N-butylation.


Accelerated column chromatography of free basic amino acids encountered in blood plasma or serum.


Gas-liquid chromatography-mass spectrometry of organomercury compounds.


Estimation of morphine by polyamide mini thin-layer chromatography.


Analysis of steroids. 23. Microdetermination of   5 -steroids after thin-layer chromatographic separation.


A novel thin-layer chromatographic system and its application to the separation of some cephalosporin compounds.


Analysis of potassium penicillin G and its degradation products by thin-layer chromatography.


The reduction of ferric myoglobin by ampholine on acrylamide gel electrofocusing.


Effects of rapid cooling on the mechanical and electrical activities of smooth muscles of guinea pig stomach and taenia coli. The effects of rapid cooling on the mechanical and electrical activities of the guinea pig taenia coli and circular muscle of the stomach were investigated. Lowering the temperature from 32 degrees to 10 degrees C (cold shock) depolarized the membrane and increased the membrane resistance in both tissues. However, in the taenia coli, an initial reduction of membrane resistance was observed. In both tissues, contracture evoked by cold shock and rapid relaxation after rewarming, preceded the changes of membrane properties. Displacements of the membrane potential did not modify the amplitude of contracture under cold shock. Caffeine and thymol modified the membrane properties, but the effects of cold shock were still observed. The effects of cold shock were also observed on K-induced contracture. It was postulated that at least two different sites of sequestered bound Ca are located in these smooth muscles and are responsible for evoking the mechanical response. One component possesses a close relation to membrane and the other component is presumably sequestered within the muscle.


Adaptation in the ventral eye of Limulus is functionally independent of the photochemical cycle, membrane potential, and membrane resistance. The early receptor potential (ERP), membrane potential, membrane resistance, and sensitivity were measured during light and/or dark adaptation in the ventral eye of Limulus. After a bright flash, the ERP amplitude recovered with a time constant of 100 ms, whereas the sensitivity recovered with an initial time constant of 20 s. When a strong adapting light was turned off, the recovery of membrane potential and of membrane resistance had time-courses similar to each other, and both recovered more rapidly than the sensitivity. The receptor depolarization was compared during dark adaptation after strong illumination and during light adaptation with weaker illumination; at equal sensitivities the cell was more depolarized during light adaptation than during dark adaptation. Finally, the waveforms of responses to flashes were compared during dark adaptation after strong illumination and during light adaptation with weaker illumination. At equal sensitivities (equal amplitude responses for identical flashes), the responses during light adaptation had faster time-courses than the responses during dark adaptation. Thus neither the photochemical cycle nor the membrane potential nor the membrane resistance is related to sensitivity changes during dark adaptation in the photoreceptors of the ventral eye. By elimination, these results imply that there are (unknown) intermediate process(es) responsible for adaptation interposed between the photochemical cycle and the electrical properties of the photoreceptor.


Quantitative description of sodium and potassium currents and computed action potentials in Myxicola giant axons. All analysis of the sodium and potassium conductances of Myxicola giant axons was made in terms of the Hodgkin-Huxley m, n, and h variables. The potassium conductance is proportional to n(2). In the presence of conditioning hyperpolarization, the delayed current translates to the right along the time axis. When this effect was about saturated, the potassium conductance was proportional to n(3). The sodium conductance was described by assuming it proportional to m(3)h. There is a range of potentials for which tau(h) and h(infinity) values fitted to the decay of the sodium conductance may be compared to those determined from the effects of conditioning pulses. tau(h) values determined by the two methods do not agree. A comparison of h(infinity) values determined by the two methods indicated that the inactivation of the sodium current is not governed by the Hodgkin-Huxley h variable. Computer simulations show that action potentials, threshold, and subthreshold behavior could be accounted for without reference to data on the effects of initial conditions. However, recovery phenomena (refractoriness, repetitive discharges) could be accounted for only by reference to such data. It was concluded that the sodium conductance is not governed by the product of two independent first order variables.


Quantal mechanism of transmitter release during progressive depletion of the presynaptic stores at a ganglionic synapse. The action of hemicholinium-3 and thiamine deprivation. In the present experiments we interfered with the mechanism of acetylcholine (ACh) synthesis in the rat superior cervical ganglion by impairing the supply of either the choline group (hemicholinium no. 3 [HC-3]treatment) or the acetyl group (thiamine deprivation). Under both conditions stimulation causes in the ganglion a progressive decline in ACh output associated with a depletion of transmitter tissue content. ACh release from the terminals of a single preganglionic fiber was estimated from the quantum content value of the evoked excitatory postsynaptic potentials (EPSP's) recorded intracellularly in the ganglion neuron under test. The present observations indicate that Poisson statistics describe transmitter release at either low or high release levels. Furthermore, the progressive decline in the rate of ACh output occurring during repetitive stimulation is shown to correspond to a progressive decrease in the number of transmitter quanta released per impulse and not to any modification in the size of individual quanta. Some 8,000 transmitter quanta proved to represent the presynaptic transmitter store initially present in those terminals on a neuron that are activated by stimulation of a single preganglionic fiber. Speculations are considered about synaptic efficacy and nerve connections in rat autonomic ganglia. It is suggested that six preganglionic fibers represent the mean input to a ganglion neuron.


Rapid changes of potassium concentration at the outer surface of exposed single neurons during membrane current flow. K(+)-sensitive liquid ion-exchanger microelectrodes are shown to be capable of measuring concentration changes which occur on a millisecond time scale. However, some quaternary ammonium ions, such as tetraethylammonium and acetylcholine, are able to block electrode function when present in concentrations as low as 10(-4) to 10(-3) M. Changes in extracellular potassium concentration caused by spike activity or voltage clamp pulses of exposed single neurons of the snail Helix pomatia may be measured by these electrodes. Quantitative analysis shows that the total amount of excess potassium found in the vicinity of the cell a short time after a clamp pulse, is in relatively good agreement with the amount of potassium carried by the membrane current.


Differential methods for identification of T-mycoplasmas based on demonstration of urease.


Workshop on the Mycoplasmatales as agents of disease. Session II. Immunology. Introductory remarks.


Chemical composition and serology of Mycoplasma pneumoniae lipids.


Role of host response in Mycoplasma pneumoniae disease.


Response of swine to Mycoplasma hyopneumoniae infection.


Models of Mycoplasma pneumoniae infection.


Heterogeneity of the members of the class Mollicutes.


Predisposing factors in Mycoplasma hyosynoviae arthritis in swine.


T-strain mycoplasmas and genital chlamydiae: inhibition of T-strain urease by hydroxamic acids.


A view of peer review.

A view of peer review.


Workshop on the Mycoplasmatales as agents of disease. Session 3. Model systems. Summary of discussion.


The early nonsurgical decompression of the facial nerve.


Control of smallpox and influenza.

Control of smallpox and influenza.


Electrocardiogram of the month. Stenosis of the left anterior descending coronary artery.


Transluminal popliteal artery dilatation.


Coumadin-induced bleeding: a mystery.

Coumadin-induced bleeding: a mystery.


Approaches to the predictive problem.

Approaches to the predictive problem.


Physician evaluation of a computer-based automated medical history system.


Relative efficacy.

Relative efficacy.


Cystinosis.

Cystinosis.


The types of affective disorders.

The types of affective disorders.


"Isoniazid and the alcoholic".

"Isoniazid and the alcoholic".


Coordinated care for children with cancer.


Assay of platelet factor 4 in plasma.

Assay of platelet factor 4 in plasma.


Abnormalities of cellular potassium concentration in uncompensated and compensated congestive heart failure.


Ectopic hyperparathyroidism with renal calculi and subperiosteal bone resorption. Report of case.


Hospitalized pentazocine abusers.

Hospitalized pentazocine abusers.


Blood sulfonamide levels in feedlot cattle with respiratory disease.


Emergency service. Challenge of the seventies.


Abomaso-duodenal anastomosis for atonic abomasum.


Interpretation of canine hemograms.

Interpretation of canine hemograms.


Practice management. Insurance necessary ingredient in success formula.


Education programs offered accreditation guide.


Standing laparotomy in the horse.

Standing laparotomy in the horse.


Air conditioning--blessing or curse?

Air conditioning--blessing or curse?


Venous disease and thromboembolism.

Venous disease and thromboembolism.


An accounting to the American Society of Plastic and Reconstructive Surgeons. Presidential address.


Blepharospasm. A new approach to treatment.


Skin excisions in reduction rhinoplasty.


On hemifacial microsomia. The first and second branchial arch syndrome.


The median transit tongue flap.

The median transit tongue flap.


Suicide attempts related to congenital facial deformities. Two unusual case reports.


Results of temporalis transfer in lagophthalmos due to leprosy.


Full-time plastic surgical research and sour grapes.


Sagging surgeons, the swing shift, and so on.


Relapsing polychondritis. Case report.

Relapsing polychondritis. Case report.


Acquired cheilitis glandularis simplex. Case report.


An adjustable double clamp for use in microvascular surgery.


Nasal tip correction in rhinoplasty.

Nasal tip correction in rhinoplasty.


Development of the cleft lip nose.

Development of the cleft lip nose.


Sudden blindness following belpharoplasty. Report of seven cases.


A new method for correction of the prominent nasal tip.


The use of vomerine flaps to cover the raw area on the nasal surface in cleft palate pushbacks. Preliminary report.


Keratosis palmaris et plantaris.

Keratosis palmaris et plantaris.


The national archives of plastic surgery.


Results of pushback operations in treatment of submucous cleft palate.


Reconstruction of your self-image.

Reconstruction of your self-image.


On"full-time plastic surgery research and sour grapes".


Possible dangers of using fabricut as a dermabrasive.


Subcutaneous mastectomy for central tumors of the breast, with immediate reconstruction.


Thermograms after repair of nerve injuries in the hand.


Visor flap reconstruction for a massive oropharyngeal defect. Case report.


Effective safety devices for the Padgett dermatome.


A device for continuous elevation of the upper extremity.


Repair of torn earlobe with preservation of the perforation for an earring.


Ultrastructural distribution of calcium in striated muscle fibres.


The target theory in the simulation of the mitotic inhibition due to molecular agents with a specific action.


Cerebral phospholipid metabolism in relation to age and species. Hormonal influences.


Drug-dependent south African national servicemen.


Tonsils in or out.

Tonsils in or out.


Whither sugar consumption?

Whither sugar consumption?


Immunotherapy and 5 percent topical 5-fluoro-uracil ointment in the treatment of condylomata acuminata.


The antero-inferior premaxillary approach to surgery of the nasal septum.


Multiple puncture tuberculin reactions. A rubber model to facilitate uniform interpretation.


Genetically determined hazards of blood transfusion within and between races.


Amyloidosis in Hodgkin's disease.

Amyloidosis in Hodgkin's disease.


Some aspects of facial nerve paralysis. II. Electrical tests and the submaxillary salivary test.


Steroids and related products. XXXVII. 11-Aza steroids. II. The synthesis of 11-aza 9 -steroids. I.


Bone densitometry of the femoral midshaft in the protein-deprived rat.


Mass spectral studies on steroidal compounds-3 6-aza compounds in the cholestane series (ring B -lactams).


A simple chemical method for the synthesis of catechol estrogens.


A novel regiospecific peroxide catalyzed halogen exchange. 5-Bromo-6 -chloro-5 -cholestan-3 -ol 3-acetate.


Steroid extraction and tissue digestion in the assay of radioactivity in rat brain following tritiated estradiol-17 .


Influence of rat estradiol binding plasma protein (EBP) on uterotrophic activity.


An enzymatic measurement of riboflavin status in man.


The liver in typhoid fever.

The liver in typhoid fever.


The normal intravenous cholangiogram following cholecystitis: a clue to the cystic duct stump syndrome.


Hypertrophic gastritis versus gastric carcinoma.


Xanthofibroma of the stomach--neoplasm or pseudotumor?


Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy.


Volvulus of the transverse colon associated with submucosal hamartomas.


Fibromatosis in Gardner's syndrome.

Fibromatosis in Gardner's syndrome.


The promise of primatology.

The promise of primatology.


Sexual behaviour of group-living adolescent chimpanzees.


Biomechanical investigations of Limnopithecus with special reference to the influence exerted by body weight on bone thickness.


Sexual dimorphism in the pelves of African lorises.


Cytogenetic study of the endemic Malagasy lemurs subfamily Cheirogaleinae Gregory 1915.


Craniofacial biology: animal surgical experimentation and clinical practice.


Oral implantology and oral carcinogenesis in primates.


The auditory sensitivity of the lemur.

The auditory sensitivity of the lemur.


Observations on spontaneous pathological lesions in chacma baboons (Papio ursinus).


Efferent connections of area 17 in Galago.


An application of cineradiography to the study of locomotion in primates.


Alkaptonuria in an orangutan (Pongo pygmaeus).


Non-nutritive sucking in great ape and human newborns.


Social correlates of reproductive success in the gibbon colony on Ko Klet Kaeo, Thailand.


Villous adenoma of rectum.

Villous adenoma of rectum.


Fulminating amoebic colitis.

Fulminating amoebic colitis.


Heme occupancy of catalase in hemoglobin-free perfused rat liver and of isolated rat liver catalase.


A lactate oxygenase from Mycobacterium phlei. II. Spectral characteristics in aerobic and anaerobic reactions.


A method for the purification of histone fraction F3 by affinity chromatography.


Hydrogen ion changes of rhodopsin I. Proton uptake during the metarhodopsin I 478  metarhodopsin II 308  reaction.


Isolation of acetylcholine receptor-- -bungarotoxin complexes from Torpedo californica electroplax.


The effect of growth temperatures on the in vivo ribose methylation of Bacillus stearothermophilus transfer RNA.


Kinetic properties of arginine phosphokinase from honeybees, Apis mellifera L. (Hymenoptera, Apidae).


Aryl hydrocarbon (benzo ( ) pyrene) hydroxylase: inducible in extrahepatic tissues of mouse strains not inducible in liver.


Purification and properties of glycogen phosphorylase from Streptococcus salivarius.


Studies on the molecular weight and lipoprotein nature of glucose-6-phosphate solubilized rat brain hexokinase.


Interactions between prostaglandin E 1  and calcium at the level of the mitochondrial membrane.


The hemoglobins of a fresh-water teleost, Cichlasoma cyanoguttatum (Baird and Girard). II. Subunit structure and oxygen equilibria of the isolated components.


Aerobic metabolism of L- -lysine in a Pseudomonas. Coenzyme A-dependent acetylation of L- -lysine.


Interaction of rat liver ribosomal subunits with homologous Met-tRNAs.


Inhibition of prolyl hydroxylase activity by bradykinin analogs containing a prolyl-like residue.


The inhibition of oxalate biosynthesis in isolated perfused rat liver by DL-phenyllactate and n-heptanoate.


Purification, properties and temperature dependence of the adenosine deaminase from a poikilotherm (bay scallop).


Physicochemical properties of the hemoglobin of the coelocanth Latimeria chalumnae.


Occupational health and economic development in African countries.


Hair as a biopsy material. 3. Assessment of environmental lead exposure.


Excretion and absorption of methyl mercury after polythiol resin treatment.


Byssinosis: a study of 10,133 textile workers.


Impairment of deep lung clearance by influenza virus infection.


Inhaled irradiated terphenyls: reaction of murine lung and liver.


Effect of nitrogen dioxide on pulmonary bacterial defense mechanisms.


Changes in dogs' lung after long-term exposure to ozone: light and electron microscopy.


2,4,5 T and the metabolism of testosterone-1,2- 3 H 2  by mouse prostate glands.


Postoperative intussusception.

Postoperative intussusception.


Misdiagnosis of pneumonia in patients needing mechanical respiration.


A nonionic surfactant and blood viscosity. Experimental observations.


Hypertrophied ligamentum flavum. Clinical and surgical significance.


Mitomycin and the healing of intestinal anastomosis. An experimental study in the rat.


Vitamin A pretreatment of stress ulcers in rats.


Threshold burning effects on distant microcirculation. II. The relationship of area burnt to microvascular size.


The cardiovascular response of the acidotic newborn to sodium bicarbonate.


Colitis cystica profunda: localized, segmental, and diffuse.


Osteomyelitis of the clavicle following subclavian vein catheterization.


Nonthrombotic arterial occlusion. Complication following brachial artery catheterization with arteriographic diagnosis and surgical treatment.


Femoral-axillary artery bypass for arm ischemia.


Authors and editors meet.

Authors and editors meet.


Surgical education in a developing country. Participation of a rural community hospital in Colombia.


Preliminary studies on the transmission of Anaplasma marginale by Boophilus microplus.


Blood urea nitrogen concentrations and packed cell volumes of normal calves and calves with diarrhoea.


"Melon-seed" bodies in bovine supraspinous bursitis.


Pasteurella anatipestifer infection in fowls in Australia.


Collagen synthesis by mesenchymal cells isolated from normal and acutely-damaged mouse liver.


The endothelium of experimental saccular aneurysms of the abdominal aorta in rabbits.


The electron microscopy of the effects of treatment with coumarin (Venalot) and by thoracic duct cannulation on thermal injuries.


Subacute sclerosing encephalitis in adult hamsters infected with Langat virus.


Symptoms in hypertension.

Symptoms in hypertension.


Care of elderly people with dementia.

Care of elderly people with dementia.


Further studies on experimental bacterial pneumonia: ultrastructural changes produced in the lungs by Salmonella cholerae-suis.


The effect of cortisone on the formation and resorption of experimental amyloid.


Not so popular psychiatry.

Not so popular psychiatry.


"Steal" syndromes and hypertension.

"Steal" syndromes and hypertension.


Plasma digoxin concentration in children with heart failure. A dosage schedule for digoxin medication is presented which has proved effective and safe in children of different ages with heart failure due to a variety of cardiac conditions. The plasma digoxin concentrations during maintenance therapy, using this schedule, agree closely with previously reported therapeutic adult plasma concentrations, though the results do not exclude the efficiency and safety of higher doses. A twice-daily dosage regimen is suggested.


Cryptogenic drop attacks: an affliction of women. A drop attack was defined as falling without warning, not apparently due to any malfunction of the legs, not induced by change of posture or movement of the head, and not accompanied by vertigo or other cephalic sensation. All 33 patients attending a neurological clinic with a primary complaint fulfilling these criteria were women, and a further seven examples were found by questioning 200 consecutive patients at a gynaecological clinic. No affected male was found.In all but one patient, falls occurred only when walking. They were not due to wearing high-heeled shoes. The average age at onset was 44.5 years and in younger women onset was often during pregnancy. The accepted causes of drop attacks were not found with certainty in any of these patients. The sex incidence and the circumstances of the falls suggest that the cause may lie in differences between the two sexes in the mechanism of walking rather than in any central disturbance. Drop attacks in women commonly occur as an isolated symptom for many years, and although distressing have no serious prognostic implications.


Rubella epidemic in a maternity unit.

Rubella epidemic in a maternity unit. Four cases of rubella, the last confirmed by laboratory tests, occurred among the nurses of a large obstetric unit. Immediate measures were taken to prevent the spread of the infection to pregnant patients and staff, and none was in fact infected.Persons susceptible to rubella and who become infected may pose a real danger to women in early stages of gestation during the incubation period. We recommend that the immune status of medical and nursing personnel working in obstetric departments should be ascertained serologically, and that rubella vaccine should be offered to those who are susceptible.


Effect of metoclopramide on gastric emptying during labour. The effect of a single dose of metoclopramide (Maxolon) on the gastric emptying rate of a liquid test meal was measured in a group of parturient women by a double-sampling dye-dilution technique. The subjects were given either metoclopramide 10 mg or sterile water by intramuscular injection on a double-blind random basis at the start of the test. The gastric emptying rate was significantly increased in those women who had received the metoclopramide as compared with those who had received the placebo.


Removal of polyps with fibreoptic colonoscope: a new approach to colonic polypectomy. By using a colonoscope diathermy snare a total of 75 polyps have been removed from sites throughout the colon in 43 patients. There was some haemorrhage in four cases but no other morbidity, and all patients were discharged home within 24 hours. The ease of this procedure suggests that it should replace colotomy and surgical polypectomy in the management of polyps inaccessible to the rigid sigmoidoscope.


Effect of oestrogen therapy on plasma and urinary levels of uric acid. Uric acid clearance studies were carried out on a low-purine diet in 22 trans-sexual men before and during oestrogen therapy for this condition (stilboestrol in 21 cases, ethinyloestradiol in one). Plasma uric acid fell in 15 of the subjects and urinary uric acid rose in 17 of 20 subjects in whom satisfactory collections were obtained. These changes are significant and it is suggested that hormonal influences are responsible for the known age and sex differences in plasma uric acid.


Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro. A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro. This technique should be investigated in other patients with agranulocytosis as a possible means of detecting toxic agents.


Operative colonoscopy.

Operative colonoscopy. In 12 patients with radiologically-proved lesions of the colon total retrograde fibreoptic colonoscopy was performed on the unopened bowel at laparotomy. Additional polyps were found in five patients, and in four of these the polyp was not readily palpable through the bowel wall. This procedure is indicated whenever there are reasonable grounds for suspecting the presence of multiple polypi.


Severe cardiovascular complication associated with prolonged starvation.


Spontaneous oesophageal rupture after carbachol therapy.


Review of schizophrenics in a rural practice over 26 years. Over 26 years some 73 patients with schizophrenia were observed. Three types were considered, true schizophrenia, schizophrenia simplex, and schizoaffective disorders. Of those traced and alive in 1971, some 18% of the group had recovered, 46% had made a social recovery, 25% were unemployed in the community, and 11% were long-stay hospital patients.


Large-bowel perforations in patients undergoing sigmoidoscopy and barium enema. Perforation of the large bowel can occur as a complication of sigmoidoscopy, rectal or sigmoid biopsy, and even of a simple cleansing enema. If the perforation is extraperitoneal there may be no early symptoms and consequently there may be delay in diagnosis. The risk of perforation during these procedures is small but it should not be ignored. The performance of a barium enema shortly after a rectal or sigmoid biopsy may slightly increase the risk by converting a partial perforation into a complete one. Precautions can be taken to minimize the hazard.


Role of teaching hospitals in a developing country.


Hepatitis.

Hepatitis.


Hyperactive children.

Hyperactive children.


Influenza outbreak.

Influenza outbreak.


Certification of hypothermia deaths.

Certification of hypothermia deaths.


Hypothermia.

Hypothermia.


Nomenclature of the new vagotomy.

Nomenclature of the new vagotomy.


Gastric ulcer after highly selective vagotomy.


"Twin" intracranial aneurysms.

"Twin" intracranial aneurysms.


Glove-powder peritonitis.

Glove-powder peritonitis.


Pulmonary oedema in pulmonary thromboembolism.


Thiocyanate metabolism in human vitamin B 12  deficiency.


Staffing of accident and emergency departments.


Dyslexia as cause of psychiatric disorder.


Complication of internal jugular venepuncture.


Making hospital geriatrics work.

Making hospital geriatrics work.


Glucagon and growth hormone.

Glucagon and growth hormone.


Nitrazepam: another interesting syndrome.


An integrated child health service.

An integrated child health service.


Ethics in epidemiological research.

Ethics in epidemiological research.


Occupational medicine?

Occupational medicine?


Children's wheelchairs.

Children's wheelchairs.


Nutritional value of school meals.

Nutritional value of school meals.


Insulin syringes.

Insulin syringes.


Side effects of lithium carbonate.

Side effects of lithium carbonate.


Anomalies in tendon reflexes.

Anomalies in tendon reflexes.


Seat belts and negligence.

Seat belts and negligence.


Chondromalacia patellae.

Chondromalacia patellae.


Screening for cervical carcinoma.

Screening for cervical carcinoma.


Operation for secondary varicose veins.

Operation for secondary varicose veins.


Use of the flexible fiberoptic bronchoscope in the diagnosis of malignant tumours of the lung.


Medullary cystic disease of the kidneys: report of a family.


Use of orthobaric oxygen in the radiotherapy of bladder tumours.


Spontaneous intracranial extradural hematoma occurring during open-heart surgery.


External sphincterotomy for the obstructed neurogenic bladder.


Renal candidiasis: diagnosis and management.


Red cell mass and plasma volume changes during transurethral resection of the prostate.


Resection of infarcts and coronary artery grafting.


Functional relations of the proximal portal components studied by different outflow-tract manipulations.


Cavernous hemangioma of the gallbladder and liver.


Aortic valve replacement--a personal viewpoint.


Modified gastroplasty: a simple operation for reflux esophagitis with moderate degrees of shortening.


In vitro demonstration of tumor-specific common antigens and embryonal antigens in murine fibrosarcomas induced by 7,12-dimethylbenz(a)anthracene.


Influence of tumor antigen on maintenance versus depression of tumor-specific immunity.


Studies with 8-azainosine, a cytotoxic nucleoside with antitumor activity.


The surface ultrastructure of normal and metaplastic cervical epithelia and of carcinoma in situ.


Effects of aflatoxin B 1  on the formation of subribosomal particles in rat liver.


Control of food intake during growth of a Walker 256 carcinosarcoma.


Chemical carcinogenesis in transposed intestinal segments.


Reduction of leukemia incidence following splenectomy in the rat.


Multiple effects of dexamethasone on protein synthesis and hyperplasia caused by a tumor promoter.


The metabolism of the naturally occurring hepatocarcinogen safrole to 1'-hydroxysafrole and the electrophilic reactivity of 1'-acetoxysafrole.


Carcinoma after malignant conversion in vitro of epithelial-like cells from rat liver following exposure to chemical carcinogens.


Spontaneous epidermal tumor in an adult newt, Cynops pyrrhogaster.


The reaction of  14 C-labelled platinum ethylenediamine dichloride with nucleic acid constituents.


Studies on the effects of   1 -tetrahydrocannabinol (  1 -THC) and DDT on the hepatic microsomal metabolism of   1 -THC and other compounds in the rat.


The preparation of ( 18 F)5-fluoro-DOPA with reactor-produced fluorine-18.


The measurement of phosphorus in human bone using radioactive neutron sources--a technique for partial body in vivo activation analysis.


A unit for the removal of tritium from laboratory atmospheres.


Studies with alkylating esters. VI. The chemical and biological activities of the isomers of dimethylmyleran.


Immunity to Vibrio cholerae in the mouse. II. Effect of a cell-adherent immune factor. Serum, peritoneal exudate cells, or spleen cells were obtained from donor mice immunized with Vibrio cholerae Ogawa 41. Normal recipients were protected from lethal Vibrio infection when challenged one day after transfer of immune serum or peritoneal cells or normal peritoneal cells exposed in vitro to immune serum. Protection of recipients of immune spleen cells was evident when the cell transfer-challenge interval was 14 days but not when it was 1 day. Transfer of immunity with peritoneal cells from actively immunized donors was long lasting, whereas that derived from in vitro treatment of normal cells was of short duration. Both a cell-adherent and a nonadhering immune factor appear to be important in this immunity.


On the preparation of dichlorodiphenyldichloroethane- 131 I (DDD- 131 I).


Cytotoxicity of concanavalin A-activated hamster lymphocytes. The ability of hamster lymphoid cells to become cytotoxic in vitro to xenogeneic human cells after stimulation with concanavalin A (ConA) was investigated by using the cell-mediated (51)Cr release test. Cytotoxicity developed by 12 to 16 hr with peak values acquired within 24 hr of stimulation with ConA. The cytotoxicity was found to be mediated by the lymphoid cells themselves rather than by soluble substances. Spleen cells were more efficient than lymph node cells in releasing radioactivity from human cells. The concentration of mitogen was found to be critical in the development of cytotoxicity. ConA concentrations of 12.5 mug or less per culture conferred upon the lymphoid cells the capacity to release (51)Cr from target cells whereas higher concentrations were ineffective and even inhibitory. The cell-mediated cytotoxicity could be reversed by methyl alpha-d-glucopyranoside, but only during the first 8 to 12 hr of stimulation. The lytic reaction did not require the presence of ConA.


Creatine phosphokinase activity in rabbit alveolar macrophages. An enzyme is present in extracts of rabbit alveolar macrophage which can catalyze the reaction of creatine phosphate with adenosine diphosphate to form adenosine triphosphate and creatine. The enzyme is moderately activated by reduced glutathione, has a pH optimum between pH 6.5 and 7.0, and shows an absolute requirement for Mg(2+). The K(m) for creatine phosphate is approximately 3.6 mm while the K(m) for adenosine diphosphate is about 1.1 mm. The enzyme may play a role in the energy balance of the cell by creating a reserve of energy in the form of creatine phosphate.


Proton magnetic resonance studies of metal complexation of nucleosides in dimethyl sulfoxide.


Approaches to analogs of anhydrogliotoxin.


Crystalline chain conformation of mycodextran.


Thermodynamics of ligand and oxygen binding to cobalt protoporphyrin IX dimethyl ester in toluene solution.


Reduction of   24  of lanosterol in the biosynthesis of cholesterol by rat liver enzymes. II. Stereochemistry of addition of the C-25 proton.


Deoxyoligonucleotide synthesis using a new phosphate protecting group.


Axenomycins. I. The structure of chromophore and sugar moieties.


Syntheses of ferrous-porphyrin complexes. A hypothetical model for deoxymyoglobin.


Axenomycins. 11. The structure of axenolide.


Nature of the copper(II) complex formed in the reaction of formaldehyde with bis((S)-serinato)copper(II).


Concerning the mechanism of action of coenzyme B 12  in dioldehydrase and related enzymes. Synthesis and reactions of postulated organocorrin intermediates.


"Who shall establish drug standards"?

"Who shall establish drug standards"?


Pharmacist cautions.

Pharmacist cautions.


APhA's bioavailability project.

APhA's bioavailability project.


American pharmacy--a retrospective future.


An accidental poisoning prevention program.


The national hypertension program.

The national hypertension program.


Factors affecting coloration of urine and feces.


Therapeutic management of common types of vaginitis.


The effect of spindle inhibitors applied before meiosis on meiotic chromosome pairing.


Hodgkin's disease.

Hodgkin's disease.


An ultrastructural study of the pancreatic acinar cell in mitosis, with special reference to changes in the Golgi complex.


Functional development of the reticular system in an insect muscle with synchronously differentiating cells.


Electrokinetic characterization of two ascites tumours: TA3 and M.Mel. 1.


The substructure of ciliary microtubules.


Differences in ploidy and degree of intercellular contact in differentiating and non-differentiating sycamore calluses.


An electron-microscope study of the extranucleolar bodies during growth of the oocyte in the prepubertal mouse.


An ultrastructural and radioautographic study of early oogenesis in the toad Xenopus laevis.


An ultrastructural study of the differentiation of the spermatozoid of Equisetum.


Kinetics of unfolding and refolding of proteins. I. Mathematical analysis.


Accumulation of messenger RNA for extracellular enzymes as a general phenomenon in Bacillus amyloiquefaciens.


Pulsed nuclear magnetic resonance studies on  23 Na,  7 Li and  35 Cl binding to human oxy- and carbon monoxyhaemoglobin.


Cleavage at the   1   1  contact and its effect on the oxygen equilibrium of human haemoglobin.


X-ray diffraction and infrared studies of an  -helical fragment from  -keratin.


Dynamic state of the messenger RNA pool specific for extracellular protease in Bacillus amyloliquefaciens: its relevance to the mechanism of enzyme secretion.


The charge relay system in chymotrypsin and chymotrypsinogen.


Ultrastructure of pig renal glutaminase. Evidence for conformational changes during polymer formation.


Pig renal glutaminase--another view.

Pig renal glutaminase--another view.


Crystalline cowpea chlorotic mottle virus.


Lipids associated with the aminoacyl-transfer RNA synthetase complex.


5-bromodeoxyuridine labeling of monomeric and catenated circular mitochondrial DNA in HeLa cells.


The measurement of dog gastric mucosal blood flow by radioactive aniline clearance compared with amidopyrine clearance. 1. Methods for the estimation of radioactive aniline in body fluids are described. The recovery of aniline added to blood, plasma and gastric juice was over 90% of the recovery from saline.2. In the doses used aniline caused methaemoglobinaemia of 5-11% of total haemoglobin. No other effect was detected. Gastric secretion was also unaffected.3. Aniline clearance increased in parallel with acid secretion from Heidenhain pouches in conscious dogs and in anaesthetized dogs. In conscious dogs the ratio of aniline clearance to acid secretion was significantly higher for histamine stimulation than for pentagastrin stimulation.4. Aniline and amidopyrine clearances were compared simultaneously in the same dogs. Aniline clearance was about 80% of amidopyrine clearance.5. The proportion of aniline bound to plasma proteins was measured by two methods and found to be 25%. When aniline clearance was corrected for plasma binding, aniline and amidopyrine clearances were equal.


Regional distribution of tidal volume in man.


The interaction of reflexes elicited by stimulation of carotid body chemoreceptors and receptors in the nasal mucosa affecting respiration and pulse interval in the dog. 1. The effects on respiration and pulse interval of stimulation of the carotid body chemoreceptors before, during and after stimulation of receptors in the nose have been studied in the anaesthetized dog.2. Stimulation of a carotid body by infusion of cyanide into the ipsi-lateral common carotid artery causes hyperpnoea and either an increase, decrease or no change in pulse interval.3. Excitation of receptors in the nasal mucosa leads to reflex apnoea or a reduction in breathing, and an increase in pulse interval.4. When the carotid bodies are excited by the same dose of cyanide during stimulation of the nasal mucosa, the chemoreceptor-respiratory response is abolished or reduced in size compared with the control effect. On the other hand, the chemoreceptor-cardio-inhibitory response is considerably enhanced.5. The potentiated cardio-inhibitory response of combined chemoreceptor and nasal stimulation could not be accounted for by the change in pulmonary ventilation, arterial P(O2) or P(CO2), or mean arterial blood pressure.6. These results indicate that excitation of the nasal reflex inhibits the chemoreceptor-respiratory reflex response but facilitates the chemoreceptor-cardio-inhibitory reflex response. The possible sites of these interactions between the nasal and chemoreceptor reflexes are discussed.


An electrophysiological investigation of the receptor apparatus of the duck's bill. 1. The properties of receptors in the duck's bill have been studied by recording from units isolated by dissecting fine filaments from the maxillary and ophthalmic nerves.2. The units studied were divisible into three groups, phasic mechanoreceptors responsive to vibration, thermoreceptive units, and high threshold mechanoreceptors.3. Vibration-sensitive mechanoreceptors (113 units) had small receptive fields, showed a rapidly adapting discharge to mechanical stimulation of the bill, were sensitive to vibratory but not to thermal stimuli and showed no background discharge.4. Temperature receptors (twenty-one units) were insensitive to mechanical stimulation and showed a temperature-dependent background discharge. Sudden cooling produced a transient increase in discharge frequency.5. High threshold mechanosensitive units (eight units) gave a slowly adapting discharge to strong mechanical stimulation and were insensitive to vibratory and thermal stimulation.6. It is concluded that the low-threshold, vibration-sensitive responses come from Herbst corpuscles. No specific function can yet be assigned to the Grandry corpuscles.


The effect of plasma proteins and capillary pressure upon the filtration coefficient of frog mesenteric capillaries.


Edge detectors in human vision.

Edge detectors in human vision. 1. The spatial properties of edge detectors were measured psychophysically with the technique of subthreshold addition. Subthreshold patterns used to add to an edge were lines, sine gratings, Gaussian edges, and ramps.2. The sensitivity profile, determined from experiments on subthreshold addition of lines to an edge was an antisymmetric function, with peak sensitivity approximately +/- 1.5' from its midpoint. Its total extent was about +/- 6'.3. The spatial frequency response of edge detectors was measured in experiments on subthreshold addition of sine gratings to an edge. The spatial frequency response was peaked at about 3 c/deg, and was broadly tuned in frequency. It was approximately equal to the Fourier transform of the sensitivity profile, implying linearity of edge detectors.4. The visibility of Gaussian edges and ramps could be explained largely in terms of the activation of edge detector neurones.5. The role of edge detectors in perception, in creating apparent brightness, and as an explanation of contour illusions, is discussed.


The short range stiffness of active mammalian muscle.


The specificity of cholecystokinin action on the gall-bladder.


An electromechanical stimulator with wide band characteristics.


Heat production in guinea-pig taenia coli muscles.


Does the threshold for small displacements of the finger pad depend on velocity?


The basis of stereoscopic vision in the sheep.


The effect of tetracaine on 2-amino-iso-butyric acid transport in muscle.


Distension of the right atrium and urine flow in the dog.


Polyneuronal innervation of kitten skeletal muscle. 1. Isometric contractions of kitten soleus and flexor hallucis longus (FHL) muscles have been examined for evidence of polyneuronal innervation. The sum of tetanic tensions of two almost equal divisions of the ventral roots was greater than the tetanic tension elicited by stimulating both the divisions simultaneously. The difference was large in kittens aged about 3 days, was less at 2 weeks and was small or absent at 6 weeks.2. A tetanus elicited from one division of the ventral root potentiated a twitch elicited from the other root division. The time course of this potentiation was similar to that of post-tetanic potentiation induced from the same root from which the twitch was elicited.3. It is concluded that polyneuronal innervation exists in the kitten limb muscles.4. The observed degree of tension excess was less if the divisions of the root were not equal. The observations were compatible with a model which assumed a random distribution of nerve axons to the muscle fibres.


The effect of spontaneous cortical activity on the cerebral response to stimulation of the contralateral cortex in the cat.


Electrical activation of visual neurones in nucleus pontis in the cat.


A method for obtaining muscle action potentials from a locust during free turning in flight.


The thermoregulatory effects of prostaglandin E 1  when infused into a lateral cerebral ventricle of the Welsh Mountain sheep at different ambient temperatures.


An uptake process for L-noradrenaline resistant to desmethylimipramine (DMI) and 17 -estradiol in the cat spleen.


Gastric mucosal blood flow relative to gastric acid secretion to different stimuli in conscious dogs.


A comparison of the hydrolysis of p-nitrophenylphosphate and a phosphoprotein intermediate of the sodium pump.


Increased thyroxine secretion following administration of dinitrophenol to rats. 1. Feeding male rats 0.2% dinitrophenol (DNP) in the diet caused weight loss, a significant fall in the plasma protein bound iodine concentration, and a rise in the thyroxine secretion rate. Thyroxine concentration was raised in the liver and intestinal tract with contents, reduced in the carcass, and unchanged in the pelt.2. Radio-iodine uptake by the thyroid gland was unchanged but there was a significant fall in the thyroid/serum activity ratio.3. Five hours after tracer radiothyroxine, DNP treated rats had a reduced fraction of dose in the plasma, with raised concentrations in the liver and intestines.4. Fractional turnover rates of radiothyroxine in plasma, liver and carcass were raised in DNP treated animals.5. DNP caused a significant increase in the biliary clearance of radiothyroxine, when measured immediately after administration of tracer and 4 hr later.6. It is postulated that DNP displaces thyroxine from its plasma binding proteins and that the displaced hormone is excreted in the bile. This wastage together with increased demand resulting from DNP induced hypermetabolism results in increased output of thyroxine by the thyroid gland.


The activity of lung afferent nerves during tracheal occlusion.


The effect of training and a mask on the voluntary endurance time of men exercising in the heat.


Mechanical models of axon structure.

Mechanical models of axon structure.


The use of entrainment in the analysis of the human thermoregulatory system.


Left ventricular contractility and developed tension in the intact dog submitted to an intracoronary infusion of adenosine. 1. The effect of adenosine on left ventricular contractility and developed tension was studied in the anaesthetized intact dog. Normal and propranolol-treated animals were used. Adenosine was infused through a catheter into one of the two main branches of the left coronary artery, usually the circumflex branch. The rate of infusion was 150 x 10(-9)M/min. The infusion was maintained during 50 min.2. In both series of animals, no change was observed in the heart rate, aortic pressure, left ventricular end-diastolic pressure, time from onset of left ventricular contraction to peak dP/dt, peak dP/dt and left ventricular tension-time index. It is concluded that a regional increase in adenosine concentration in the left ventricular wall has no inotropic effect when the adrenergic mechanisms are normal or depressed.3. The myocardial blood flow response to adenosine was determined at the 10th, 30th and 50th min of the infusion by the radioactive inert gas method. At the 10th min of the infusion, the myocardial blood flow averaged three times the control value in both series of dogs. Thereafter, the flow response remained stable in the normal dogs but declined at the 50th min of the infusion in the propranolol-treated animals. It is suggested that autoregulation of the coronary circulation in response to overperfusion of the myocardium at constant cardiac work may be enhanced at the lower myocardial oxygen requirements of the propranolol-treated dogs while, in the normal animals, it was insufficient to overcome the potent coronary dilator action of adenosine.


Specific transfer process for intestinal absorption of peptides.


The effect of glycine-conjugated bile acids on net water and glucose transport, and transmural potential difference, across isolated rat jejunum.


Intestinal transport of zinc by rat duodenum.


Microstrain measurements of the deformation of compact bone.


Types of afferent nervous activity which may be measured in the vagus nerve of the sheep foetus. 1. Afferent activity was measured in the vagus nerves in sixteen foetuses within 2-3 days of natural term and in two foetuses 130 and 135 days gestational age, exteriorized by hysterotomy from seventeen ewes given either a spinal anaesthetic (ten) or pentobarbitone sodium (seven).2. Activity from aortic chemoreceptors was observed which increased in rate with foetal hypoxia, NaCN or nicotine and temporary occlusion of the umbilical cord or veins. Activity was abolished or reduced with saline equilibrated with air.3. Activity from baroreceptors was observed which was synchronous with the arterial pulse and which followed changes in arterial pressure.4. Activity designated as arising from stretch receptors in the lungs or lower airways was observed which consisted of a regular discharge at 15-45 impulses sec(-1), which varied with intra-tracheal pressure, which increased with negative intrathoracic pressure generated by spontaneous respiratory movements, which, when the umbilical cord was occluded, at first increased in rate and then fell to zero at or about the occasion of the first breath. After breathing had been established, activity assumed the rhythmical pattern and showed evidence of slow adaptation of receptors seen in the adult. This activity was frequently modulated by the heart beat and after breathing had started it was reduced when carbon dioxide was raised.5. Respiratory movements with a frequency of 10-20/min occurred spontaneously in foetuses from ewes given a spinal anaesthetic and were associated with a modulation of the stretch receptor discharge. They could be induced by withdrawing fluid from the trachea and so lowering both intra-tracheal pressure and receptor discharge and were abolished by raising intra-tracheal pressure. These changes were abolished by sectioning the vagi just caudal to the nodose ganglion.6. These results indicate that there are excitatory and inhibitory pathways in the vagus nerves which are active in the foetus and which may well be concerned with the limitation of respiratory movements of the foetus and the onset of maintained respiration at birth.


Continuous on-line spectral analysis of muscle tremor.


Elevation in set point for body temperature regulation after prolonged exercise. 1. In nine healthy men, after prolonged exercise (approximately 37 km walk and 2.5 km ascent and descent in 9 hr) deep body temperature at rest stabilized at a higher level than in the absence of previous exercise.2. The increase, approximately 0.36 degrees C, was recorded at both oral and rectal sites. It persisted while the subjects rested in warm and in cool surroundings, and disappeared about 11 hr after the end of exercise.3. The increase in body temperature after exercise was accompanied by a similar increase in the body temperature at which sweating started during body heating.4. After exercise the subjects' metabolic response to cold air (13.6 degrees C) was normal or increased in spite of the elevation in body temperature.5. Blood glucose concentration was never lower than 3.1 mM during these experiments.6. The temperature changes are most easily explained by mild pyrexia due to the release of endogenous pyrogen associated with minor tissue damage.


Failure of thermoregulation in the cold during hypoglycaemia induced by exercise and ethanol. 1. After young men had exercised for approximately 2 hr at 70% maximum O(2) uptake, and taken 28 ml. ethanol by mouth, their mean blood glucose fell to 2.17 mM. It fell further to 1.77 mM during a 30 min exposure to air at 14.5 degrees C. Plasma lactate, glycerol, beta-hydroxybutyrate and free fatty acid concentrations increased.2. Rectal temperature fell to reach a mean level of 34.49 degrees C by the end of the cold exposure; oesophageal temperature fell to as low as 33.00 degrees C in one case.3. Virtually no increase in metabolic rate and no visible shivering occurred during the cold exposure.4. Administration of glucose (mean 60.4 g) prevented the falls in temperature, and restored metabolic response to the cold to the size found in control experiments without exercise or ethanol.5. Neither exercise without ethanol or ethanol without exercise significantly lowered the blood glucose or impaired the maintenance of body temperature in the cold.6. One obese subject showed almost as great a fall in blood glucose and depression of metabolic response to cold as the thinner men, but no fall in body temperature.


Acidaemia produced by sympathomimetic amines and sympathetic nerve stimulation.


The fate of chromosome aberrations.

The fate of chromosome aberrations.


Biological shape and visual science. I.

Biological shape and visual science. I.


A cytokinetic model for heterogeneous mammalian cell populations. I. Cell growth and cell death.


Effects of noradrenaline and isoprenaline, in combination with  - and  -receptor blocking substances, on the action potential of cardiac Purkinje fibres. 1. The effects of noradrenaline and isoprenaline on the repolarization phase of the action potential have been studied in the Purkinje fibres of sheep heart, electrically driven at constant rates.2. Isoprenaline (2, 5 and 8 x 10(-8) g/ml.) increases the slope of phase 2 of repolarization and decreases the plateau length; the resulting decrease in action potential duration is concentration dependent, but not rate dependent.3. The effect of isoprenaline on the action potential duration is entirely blocked by propranolol (10(-7) g/ml.) and unaffected by phentolamine (5 x 10(-7) g/ml.).4. In phentolamine (5 x 10(-7) g/ml.) pretreated preparations the response induced by noradrenaline (5 x 10(-8), 1 and 5 x 10(-7) g/ml.) is very similar to that induced by isoprenaline.5. In propranolol (2.5 x 10(-7) g/ml.) pretreated preparations noradrenaline causes a lengthening of the plateau phase and an increase in action potential duration.6. The relationship of these results to the presence of both alpha- and beta-receptors in cardiac Purkinje fibres is discussed.


An approach to a physico-chemical model of olfactory stimulation in vertebrates by single compounds.


A perturbation method for the analysis of impulse propagation in a mathematical neuron model.


Use of a mathematical model to bridge the clinic-laboratory gap: local spread of endometrial cancer.


Polymorphic pattern formation in the fungus Nectria.


Toxicity in HeLa cells mediated by plastic wraps.


Practical course in liquid scintillation counting. I. Principles and chemistry.


Fascial sling suspension of the chin following resection of the anterior mandible.


Naasal venous drainage and the foramen caecum.


Foreign body in the airway: a review of 202 cases.


Laryngopyocele.

Laryngopyocele.


Canine fossa puncture.

Canine fossa puncture.


Cricoarytenoid arthritis due to mumps.

Cricoarytenoid arthritis due to mumps.


Labyrinthine compensatory eye position of the guinea pig.


Experimental evaluation of in situ oncocide for primary tumor therapy: comparison of tumor-specific immunity after complete excision, cryonecrosis and ligation.


The management of otogenic lateral sinus disease at Groote Schuur Hospital.


Chairman's introduction.

Chairman's introduction.


Checks and balances in animal populations.


Natural checks and balances in man.

Natural checks and balances in man.


Human influences on life-supporting systems.


An analysis of future population pressures.


Syndrome of the sea-blue histiocyte.

Syndrome of the sea-blue histiocyte.


Medical research in the university hospital.


Veterinary research in the university.

Veterinary research in the university.


Dissolution of renal uric acid stones complicating ileostomy.


Biological chemistry in the university.

Biological chemistry in the university.


Carcinogens and food: a broad assessment.


The pre-registration year and the undergraduate curriculum.


Problems of biological and paraclinical research within the environment of a research institute structure.


A pre-registration appointments scheme.

A pre-registration appointments scheme.


Pre-registration year.

Pre-registration year.


Effects of vasectomy on population control and problems of reanastomosis.


Vasectomy: problems of follow up.

Vasectomy: problems of follow up.


The Agricultural Research Council.

The Agricultural Research Council.


Clinical and genetic aspects of malignant hyperpyrexia.


Histopathological and neuropharmacological aspects of malignant hyperpyrexia.


The Medical Research Council and the support of biomedical research in the United Kingdom.


The support of medical research by charitable foundations.


Clinical, electrophysiological and pathological studies on malignant hyperpyrexia.


Environment and behaviour.

Environment and behaviour.


Deviant behaviour in relation to mental disorder.


The role of the Department of Health & Social Security in research and development.


The effect of the environment on the individual.


Hereditary spherocytosis, haemochromatosis, diabetes mellitus and chondrocalcinosis.


Whither sugar consumption?

Whither sugar consumption?


Drug-taking patterns in the National Service.


Tonsillectomy.

Tonsillectomy.


Aspects of bacterial endocarditis in the Johannesburg General Hospital. An analysis of 30 cases.


The aetiology and bacteriological monitoring of bacterial endocarditis at the Johannesburg General Hospital.


Septic abortion and septic shock.

Septic abortion and septic shock.


The treatment of intestinal and hepatic amoebiasis.


Surgical sepsis.

Surgical sepsis.


The fate and surgical significance of adenoma of the thyroid gland.


Value, complications, and limitations of umbilical vein catheterization.


Aneurysms of the splenic artery.

Aneurysms of the splenic artery.


The use of subclavian central venous catheters in gynecology and obstetrics.


Manometric evaluation after posterior gastropexy for treatment of strictures of the esophagus secondary to reflux.


Carcinoma of the female urethra.

Carcinoma of the female urethra.


The management of lymphedema by staged subcutaneous excision.


Polyglycolic acid suture in routine sports injury surgical practice.


Measurement of cardiac output with radioactive xenon.


A national registry for patients with chronic kidney disease.


Endorectal split sleeve pull-through procedure for Hirschsprung's disease.


A graphic method for bedside estimation of pulmonary arteriovenous shunting.


An analytic critique of existing systems of staging for breast cancer.


Ambulatory surgical care: basic concept and review of 1,000 patients.


A surgeon's view of a community health center.


Experimental arterial embolism: a study using scanning electron microscopy to identify changes in luminal surface ultrastructure after exposure to implanted emboli.


Venous occlusion in the canine hindlimb: hemodynamic effects of adrenergic stimulation and blockade.


Arteriovenous fistula and false aneurysm as the cause of consumption coagulopathy.


Bile reflux in experimental stress ulcer.


Secretin-gastrin relationships in Zollinger-Ellison syndrome.


Cardiovascular effects of arteriovenous shunt rewarming following experimental hypothermia.


The pulmonary hemodynamic effects of lung thromboemboli in dogs.


A new intracaval filter permitting continued flow and resolution of emboli.


Exclusion of the right ventricle from the circulation: hemodynamic observations.


Ruptured aneurysms of the hypogastric artery.


Effect of metabolic inhibitors on the gastric mucosal barrier.


Ambulatory health-care delivery and the surgeon.


Who should perform peripheral vascular surgery?


Gallstone disease in Sweden versus Japan. Clinical and etiologic aspects.


Renal circulation during hypotension.

Renal circulation during hypotension.


Pericardioesophagoplasty. A new operation for partial esophageal replacement.


Effects of autotransfusion on blood elements.


Importance of early diagnosis in the treatment of carcinoma of the colon and rectum.


Natural history of diverticular disease of the colon in young patients.


Jejunal interposition as remedial operation for severe dumping syndrome.


Management of a high-risk intestinal anastomosis.


Argentaffin adenoma of the trachea.

Argentaffin adenoma of the trachea.


An experimental model for the study of spondylotic myelopathy.


Ureterocolic fistula.

Ureterocolic fistula.


Extrapulmonary melioidosis.

Extrapulmonary melioidosis.


Damage to the intrahepatic biliary system from the use of the balloon-tipped catheter.


Heterotopic gastric mucosa of gallbladder.


Pelvic lipomatosis.

Pelvic lipomatosis.


A new operation for the anatomic correction of chronic intermittent gastric volvulus.


T tube catheter drainage of the duodenal stump.


Barium peritonitis. A new therapeutic approach.


Technic of tracheostomy in the adult.

Technic of tracheostomy in the adult.


Technical note on arterial catheterization in infants.


Midline cervical cleft of the neck with associated branchial cyst.


Status of college and university programs of practicum in the schools.


Bureaucracy is the noblest of institutions.


Changes in globin synthesis with erythroid cell maturation in sickle thalassemia.


Iron fortification of food: its measurement by the extrinsic tag method.


Relation between bleeding time and platelet connective tissue reaction after aspirin.


Enzymic studies on phosphatidic acid synthesis in human platelets.


Effect of endotoxin on granulopoiesis and the in vitro colony-forming cell.


Hemodialysis coil-induced transient neutropenia and overshoot neutrophilia in normal man.


Kinetics of lymphocytes in chronic lymphocytic leukemia. I. Equilibrium between blood and a "readily accessible pool".


An unusual cytoplasmic ribosomal structure in pathologic lymphocytes.


The hemolytic anemia of magnesium deficiency in adult rats.


Intravascular hemolysis associated with intravenous urea infusions in normal individuals.


B 12  dependence of cell uptake of serum folate: an explanation for high serum folate and cell folate depletion in B 12  deficiency.


The discocyte-stomatocyte equilibrium of normal and pathologic red cells.


Methods of assessing obstruction in dilated ureters.


Vesico-intestinal fistulae and recto-urethral fistulae.


An experimental model for evaluating drug effects on the ureter.


The types of neuropathic bladder dysfunction associated with prolapsed lumbar intervertebral discs.


A urodynamic view of the clinical problems associated with bladder neck dysfunction and its treatment by endoscopic incision and trans-trigonal posterior prostatectomy.


The management of superficial bladder tumours with intravesical Epodyl.


The wide bladder neck in children.

The wide bladder neck in children.


The treatment of interstitial cystitis by cystolysis with observations on cystoplasty.


Carcinoembryonic antigen and urothelial carcinoma.


Evaluation of the child with isosexual precocious puberty.


Practice management. Considerations in forming a group practice.


Spontaneous extravasation of urine secondary to ureteric obstruction.


The value of reporting communicable disease.


Recording adolescent physical changes: Tanner's system.


Focusing on Delaware Health Services Authority.


A new state board medical examination--now.


Some biochemical effects of insulin and steroid hormones on the rat prostate in organ culture.


Effect of phytohaemagglutinin on the carbohydrate metabolism of human blood lymphocytes after inhibition of the oxidative phosphorylation.


Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation.


Androgen-stimulated labelling of chromosomal proteins by isolated prostate nuclei.


The inner membrane of mitochondria under influence of triiodothyronine and riboflavin deficiency in rat heart muscle and liver: a quantitative electronmicroscopical and biochemical study.


Serum and lymphocyte activation by phytohaemagglutinin (PHA).


A growth factor for animal cells derived from peptone. I. Isolation and characterization of the growth factor.


Requirement for cell proliferation for the effects of 5-bromo-2'-deoxyuridine on cultures of chick chondrocytes.


DNA polymerase activity in phytohemagglutinin-stimulated and non-stimulated human lymphocytes.


The inhibition of locomotion of the polymorphonuclear leucocyte by organophosphorus compounds.


The sensitivity of one-cell mouse embryos to pyruvate and lactate.


Changes in the pattern of RNA synthesis in different tissues of Xenopus larvae during induced metamorphosis.


Nucleoprotein methylation in salivary gland chromosomes of Sciara coprophila: correlation with DNA synthesis.


Charasteristics of the cell cycle of matrix cells in the mouse embryo during histogenesis of telencephalon.


Lateral geniculate body response to a variable stimulus frequency.


Differential projections of the anterior and posterior cingulate gyrus to the thalamus in the cat.


Effect of long-term L-dopa administration on brain biogenic amines and behavior in the rat.


Deprivation of pattern vision studied by visual evoked potentials in the rat cortex.


Maturation of the electroretinogram in the dog.


Visual discrimination during reticular stimulation in the alert cat.


Ultrastructure of chicken slow muscle after nerve cross union.


Regional changes in cerebellar creatine phosphate metabolism during late maturation.


New horizons in industrial health.

New horizons in industrial health.


Impact of environmental fear on public health nurses.


Observations on evaluation of family planning programs.


Epidemiology of gallbladder disease in an Appalachian community.


Abortion surveillance program of the center for disease control.


Viral hepatitis in a community.

Viral hepatitis in a community.


Use of health services in a rural community.


Schizophrenic intelligence, symptoms, and release from the hospital.


The irregular discharge as an unobtrusive measure of discontent among young psychiatric patients.


Perceived congruence among premarital couples as a function of neuroticism.


Effect of excessive overtraining and aversive feedback on reversal and extradimensional shifts in schizophrenics.


Heroin addiction: its relation to sexual behavior and sexual experience.


Changes in descending pain threshold related to rate of noxious stimulation.


Reactions of convicted rapists to sexually explicit stimuli.


A comparison of replication techniques in the modification of minimal dating behavior.


Aversion therapy for sexual deviation: contingent shock and covert sensitization.


The effect of experimentally induced failure, self-esteem, and sex on cognitive differentiation.


Risk taking and hedonic mood stimulation in suicide attempters.


Phasic activity of muscles within the lower extremities.


Suggested ("hypnotic") visual hallucinations: experimental and phenomenological data.