Photoreactivation of ultraviolet-induced chromosomal aberrations. Ultraviolet induces only chromatid-type aberrations in synchronized G(1) V-79 Chinese hamster and A8W243 Xenopus tissue culture cells. Posttreatment with white light prevents expression of most potential aberrations in the A8 toad cell, which possesses a photoreactivation enzyme. We conclude that the major ultraviolet-induced DNA lesion leading to chromosomal aberrations is the pyrimidine dimer.


Freeze-fractured Acholeplasma laidlawii membranes: nature of particles observed. Freeze-fracture of Acholeplasma laidlawii membranes from cells incubated in the presence of puromycin or omission of amino acids reveals a decrease in the number of particles between 50 and 100 angstroms in the hydrophobic fracture plane, which strongly suggests that these particles are protein. Additional evidence indicates that they may be involved in substrate transport.


Membrane recycling: vesiculation of the amoeba contractile vacuole at systole. Ultrastructural data on the protozoan Amoeba proteus support a model of membrane recycling. At systole the amoeba contractile vacuole fuses with the cell surface and expels its contents. Observations by electron microscopy indicate that, as the vacuole empties, its bounding membrane transforms into tiny (35 nanometers in diameter) vesicles, identical to the vesicles that segregate fluid and contribute to the diastolic vacuole.


Natural selection of parental ability to vary the sex ratio of offspring. Theory and data suggest that a male in good condition at the end of the period of parental investment is expected to outreproduce a sister in similar condition, while she is expected to outreproduce him if both are in poor condition. Accordingly, natural selection should favor parental ability to adjust the sex ratio of offspring produced according to parental ability to invest. Data from mammals support the model: As maternal condition declines, the adult female tends to produce a lower ratio of males to females.


Memory and hibernation in Citellus lateralis. Squirrels learned to escape from a water bath by making a visual discrimination. Twenty-four hours after reaching criterion for learned behavior, the animals were exposed to the first of two 11-day cold exposures. The animals that hibernated had better retention of the learned behavior.


Nitrosation in the environment: can it occur?


Location of large core synaptic vesicles in the dorsal gray matter of the cat and dog spinal cord.


Fine structure of the atrioventricular node as viewed in serial sections.


Penetration of peroxidase into peripheral nerve fibers.


Blood supply of the human fetal mandible.


Intercellular connective tissue fibrils in the notochordal epithelium of the early chick embryo.


The uses of hypnosis in behavior therapy.


Hypnosis and behavior modification combined with psychoanalytic psychotherapy.


"Hypnosis" as a facilitator in behavior therapy.


Posthypnotic suggestion as higher-order conditioning: a methodological and experimental analysis.


Increased resolving power from scintillation cameras using electronic signal processing and a movable filter plate.


Collimator performance for scintillation camera systems.


Correlation of ultrasound and colloid scintiscan studies of the normal and diseased liver.


A study of availability of iodine from calcium iodate employing  131 I-labeled salt.


Radiation dose to breast-feeding child.

Radiation dose to breast-feeding child.


Gamma-camera study of the hepato-biliary excretion of  131 I-thyroxine-glucuronide and  131 I-rose bengal in the rat.


Calculating the radiation dosage to an organ.


System for handling and dispensing  133 Xe.


Serendipity in cisternography.

Serendipity in cisternography.


Arachnoid cyst of the posterior fossa demonstrated by isotope cisternography.


Performing  18 F bone scans on the gamma camera.


The synthesis of  18 F-5-fluorouracil. VII.


Temperature acclimation in aerobic bio-oxidation systems.


Congressional intent of the 1972 Federal Water Pollution Control Act.


Local initiative in pollution control.

Local initiative in pollution control.


Mercury methylation in an aquatic environment.


Water quality and our future environment--a Federation view.


Marine waste disposal--a comprehensive environmental approach to planning.


A remote pollution monitor.

A remote pollution monitor.


Alcoholic liver disease.

Alcoholic liver disease.


Hepatobiliary disease associated with ulcerative colitis.


Hepatic iron overload.

Hepatic iron overload.


Coagulation abnormalities in liver disease.


Ascites: pathogenesis and treatment.

Ascites: pathogenesis and treatment.


Percutaneous transhepatic cholangiography.


Fulminant hepatic failure.

Fulminant hepatic failure.


The physiology of pregnancy: clinical pathologic correlations. 2.


Atrioventricular nodal arrhythmias in atrial fibrillation.


Suicide: a dilemma for medicine, law and society.


Gallstones: pathophysiology and dissolution.


Needed: a change in attitudes toward elective sterilization.


Chronic active liver disease: classification and treatment.


Street nurses in blue jeans.

Street nurses in blue jeans.


The nucleus basalis of the pigeon: a single-unit analysis.


The neuronal organization of the inferior colliculus of the adult cat. I. The central nucleus.


The mode of innervation of the dorsal lateral geniculate nucleus and the pulvinar of the rabbit by axons arising from the visual cortex.


The number of Purkinje cells and inferior olivary neurones in the cat.


Observations on the fine structure of the central nucleus of the inferior colliculus of the cat.


Observations on complex vesicles, neurofilamentous hyperplasia and increased electron density during terminal degeneration in the inferior colliculus.


Inhibition of ADP-induced platelet aggregation by furosemide.


Cerebrospinal fluid folate, and vitamin B 12  in anticonvulsant-induced megaloblastosis.


Quantitative relationships of the pituitary-gonadal axis in postmenopausal women.


Thrombokinetic studies in alcohol-related thrombocytopenia.


The determination of factor X in tissue homogenates. Evidence for the inactivation of Russell's viper venom by tissue homogenates in the presence of plasma.


Evidence for the presence of prostaglandin-like material in the plasma of dogs with endotoxin shock.


Novel analgetics and molecular rearrangements in the morphine-thebaine group. 30. 16-Alkyl-6,14-endo-ethenotetrahydrothebaines.


A conformational study of phenethylamine receptor sites. 1. Syntheses of semirigid analogs of  -methylamphetamine.


A conformational study of phenethylamine receptor sites. 2. Synthesis of dl-2-amino-3-phenyl-trans-decalins and dl-2-isopropylamino-3-phenyl-trans-decalins.


Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N'-bis(3-aminopropyl)nonane-1,9-diamine.


Mass spectral analysis of glucuronides.

Mass spectral analysis of glucuronides.


Conformational aspects of systems related to acetylcholine. 5. Syntheses of the dl-2(e)-methyl-,dl-3(e)-methyl-, and dl-2(e),3(e)-dimethyl-3(a)-trimethylammonium-2(a)-acetoxy-trans-decalin halides.


Cyclobutane analogs of acetyl  -homocholine.


Acridan-4-carboxylic acids and N-aryl-2-amino-3-toluic acids as planar and antiplanar analogs of antiinflammatory N-arylanthranilic acids.


1,2-benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides as antiinflammatory agents.


Synthetic antidiarrheal agens. 1. An approach to the separation of antidiarrheal activity from narcotic analgesic activity.


Synthesis of methylene- and carbonyl-bridged analogs of iodothyronines and iodothyroacetic acids.


Preparation of 7-chloro steroids.

Preparation of 7-chloro steroids.


Novel analgetics and molecular rearrangements in the morphine-thebaine group. 29. Aryl and arylalkyl tertiary alcohols in the 6,14-endo-ethenotetrahydrothebaine series.


Novel analgetics and molecular rearrangements in the morphine-thebaine group. 28. Derivatives of 6,14-endo-etheno-7-oxo-6,7,8,14-tetrahydrothebaine and 6,14-endo-etheno-6,7,8,14-tetrahydrothebaine.


Permanent atrial pacing. Improved methods of electrode implantation and current therapeutic uses.


Atriopulmonary shunt.

Atriopulmonary shunt.


Effects on metabolism and cardiac output of glucose-potassium solution, with and without insulin.


The free internal mammary artery bypass graft. Use of the IMA in the aorta-to-coronary artery position.


Scanning electron microscopy of alveolar surface topography in induced acute respiratory insufficiency.


The adult form of pulmonary hamartoma. A reappraisal.


Successful treatment of postintubation subglottic stenosis with intralesional steroid injections.


Myoplasty for closure of tracheobronchial fistula.


Radiologic seminar 123: pseudocoarctation of the aorta.


"The health care crisis" (?).

"The health care crisis" (?).


Orange pulp small bowel obstruction in a postgastrectomy patient: a case report.


Acute bronchial asthma. Relations between clinical and physiologic manifestations.


Posterior ventricular aneurysms. Etiologic factors and results of surgical treatment.


The British experience in medical malpractice: an upward trend.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-1973.


Spirometry in asthma.

Spirometry in asthma.


Surgical treatment of ventricular aneurysms.


Asthma, emboli and cardiac arrest.

Asthma, emboli and cardiac arrest.


Pulmonary complications of cancer chemotherapy.


Intraductal activation of human pancreatic zymogens.


Ramsay Hunt with contralateral Bell's.

Ramsay Hunt with contralateral Bell's.


Prognosis in low renin hypertension.

Prognosis in low renin hypertension.


Monopoly in medicine.

Monopoly in medicine.


The effect of epinephrine on platelet aggregation in normal and atopic subjects.


Localized heat and cold urticaria. Rare phenomena occurring in the same individual.


Twin bill on tumor immunity.

Twin bill on tumor immunity.


Assessing health quality--the case for tracers.


The monocyte: new concepts of function.

The monocyte: new concepts of function.


"A hospital the enemy calls Bach Mai".

"A hospital the enemy calls Bach Mai".


Rebuild Bach Mai Hospital of Hanoi.

Rebuild Bach Mai Hospital of Hanoi.


Standardization of factor VIII preparations.


CPK activity in hypoparathyroidism.

CPK activity in hypoparathyroidism.


Plasma and spinal-fluid blocking factor in SSPE.


Serum renin: black and white.

Serum renin: black and white.


Tuberculin reactions.

Tuberculin reactions.


Anaphylactic reaction to arginine infusion.


Nitroblue tetrazolium test in lymphomas.


Gonorrheal polyarthritis.

Gonorrheal polyarthritis.


Intrarenal resetting of glomerulotubular balance in a patient with postobstructive uropathy.


Excessive ultrafiltration due to intracoil fibrin deposition as a complication of coil reuse.


The diagnostic and therapeutic value of spironolactone in patients with systemic hypertension.


Is a scanning ion microscope feasible?

Is a scanning ion microscope feasible? Atomic collisions of high-energy heavy ions produce large yields of x-rays. The small de Broglie wavelength of massive ions leads to an estimate of 0.2 angstrom for the resolution of a microscope utilizing nitrogen ions with energies of 14 million electron volts. Estimates of the yield of x-rays relative to molecular radiation damage of the bases in DNA are made.


Unisexual fish: laboratory synthesis of a "species". By hybridizing bisexual (gonochoristic) fishes, all-female clones have been produced that are comparable to those of a wild unisexual "species," Poeciliopsis monacha-lucida, living in northwestern Mexico. The laboratory unisexuals have consistently given birth only to female progeny for six generations.


Connectivity patterns of crayfish giant interneurons: visualization of synaptic regions with cobalt dye. Intracellular injection of cobalt dye was used to visualize electrical synapses between two pairs of central giant interneurons and giant motoneurons in the crayfish central nervous system. A pair of giant motoneurons in each ganglion contacts the interneurons, but not all contact points are functional synapses. Cobalt dye reveals numerous fine projections that are present at synaptic contact points and absent at nonsynaptic contacts; intracellular recording confirms this correlation. The different connectivity patterns of the two pairs of interneurons are consistent with the different behavior patterns which they evoke.


Endothelial cell membranes: polarity of particles as seen by freeze-fracturing. Freeze-fracturing shows particles within membranes. In plasma membranes of most cells the particles are more strongly bound to the inner half. In unfixed endothelial cells, this polarity is reversed. Glutaraldehyde fixation results in conventional polarity. The reverse polarity may be related to a mechanism for preferential fusion of pinocytotic vesicles with the plasma membrane.


Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin. Extracts of sonicated liver microsomes that are prepared from rats deficient in vitamin K or from rats given vitamin K antagonists contain a factor that liberates a thrombin-like activity when it is incubated with venom from Echis carinatus. The amount of this factor is low in control rats and in hypoprothrombinemic rats given vitamin K 1 hour before they were killed. These data indicate that this factor is a protein precursor of prothrombin, which is synthesized in the liver.


Water excretion by hydra.

Water excretion by hydra. Hydra were cut so that regenerates consisting only of the central gastric region were formed. This region, which has no natural opening to the environment, is capable of osmoregulation and of removing excess fluid from the gut. The fluid is excreted through a break in the body wall created as a result of a strong contraction when the gut is distended with fluid. A normal hydra, therefore, must remove excess fluid by contracting and expelling it through its mouth.


Calcium-induced ciliary reversal in the extracted models of "Pawn", a behavioral mutant of Paramecium. "Pawn," a genic mutant of Paramecium aurelia, cannot swim backward as the wild type can upon proper stimulation. In contrast, after membrane disruption by Triton X-100, the adenosine triphosphate-magnesium reactivated models of Pawns swim backward in the presence of calcium as wild-type models do. Thus, the mutant phenotype is due to an impairment in the membrane and not in the calcium-sensitive motile system.


The repair of defects of the muscular portion of the ventricular septum.


Metatarsalgia.

Metatarsalgia.


T tubes, the surgical amulet after choledochotomy.


Management of acute traumatic injuries of tracheobronchial tree.


The objective study of incontinence after repair operations.


Quantitative distribution of serotonin in the gastric mucosa of the dog.


Intrahepatic cholangiojejunostomy in the management of malignant biliary obstruction.


Nonsurgical treatment of intestinal perforation due to peritoneal dialysis.


Hypoxemia during aeromedical evacuation.


Disappearance of indocyanine green during circulatory shock.


The significance of bacterial flora in carcinoma in chronic osteomyelitis.


Experience with hyperparathyroidism.

Experience with hyperparathyroidism.


Aspiration in patients with tracheostomies.


Correlation of hyperfibrinogenemia with major thromboembolism in patients with cancer.


Confidence in the negative transrectal needle biopsy.


Clinical and pathologic features of Burkitt's lymphoma.


Pulmonary insufficiency.

Pulmonary insufficiency.


Extrinsic duodenal obstruction in children.


A modified one stage pull through operation for carcinoma or prolapse of the rectum.


Blood glucose, plasma insulin and coronary heart disease.


Psychosocial factors and myocardial infarction--why and how?


Polyparametric information of the electrocardiogram in injured tissue.


Exercise ECG, its prognostic significance.


Angina pectoris and ECG abnormalities in relation to prognosis of coronary heart disease in population studies in Finland.


The Ischaemic Heart Disease Register as a frame for preventive measures.


Emotions, catecholamines and coronary heart disease.


Early diagnosis of coronary heart disease--what is it good for?


Nuclear magnetic resonance studies of the solution chemistry of metal complexes. Determination of formation constants of methylmercury complexes of selected carboxylic acids.


Electroanalytical and spectral study of bilirubin in dimethyl formamide.


Fluorescence and phosphorescence of phenylethylamines and barbiturates. Analysis of amphetamine and barbiturate preparations.


High resolution field ionization mass spectrometry of bacterial pyrolysis products.


Graphite rod atomizer in atomic absorption spectrometry for direct determination of iron in serum.


Simple separation of vitamins D from sterols and retinol by argentation thin-layer chromatography.


Determination of 17-hydroxycorticosteroids with p-hydrazinobenzenesulfonic acid-phosphoric acid.


Characterization of aryl glucuronic acid conjugates by derivatization and mass spectral analysis.


Method for selective introduction of trimethylsilyl and perdeuterotrimethylsilyl groups in hydroxy steroids and its utility in mass spectrometric interpretations.


"The sanctity of life": an analysis of a concept.


Factors affecting radioimmunoassays: specifically that of human luteinizing hormone using labeled human chorionic gonadotropin.


Training program in medical oncology.

Training program in medical oncology.


Validation of the American Board of Internal Medicine written examination. A study of the examination as a measure of achievement in graduate medical education.


Changing attitudes to hypertension.

Changing attitudes to hypertension.


Plasma aldosterone in terminal renal failure.


Examining the examination.

Examining the examination.


The reader's debt.

The reader's debt.


Recommendations on choice of peritoneal dialysis solutions.


Carcinoembryonic antigen revisited.

Carcinoembryonic antigen revisited.


The Board and clinical competence.

The Board and clinical competence.


Infections after splenectomy.

Infections after splenectomy.


Alcohol and ventricular arrhythmia.

Alcohol and ventricular arrhythmia.


Methadone in Tang.

Methadone in Tang.


Students educating about drugs.

Students educating about drugs.


Urine cobalt in iron deficiency.

Urine cobalt in iron deficiency.


Triiodothyronine in diagnosis.

Triiodothyronine in diagnosis.


Hypertension: deficient care of the medically served.


Familial occurrence of asthma, nasal polyps and aspirin intolerance.


Clinical interpretation of bilateral hilar adenopathy.


Interaction of sodium warfarin and disulfiram (antabuse) in man.


Hyperbaric oxygen therapy: size of infarct determines therapeutic efficacy.


Lactulose enemas.

Lactulose enemas.


Suppression of factor IX antibody in hemophilia B by factor IX and cyclophosphamide.


Urate deposition disease. How is it regulated and how can it be modified?


A correlation between the carcinogenicity of isomeric N-hydroxy-N-acetylaminofluorenes and their in vitro effect on mitochondria.


Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine.


Stimulation of the phosphorylation of mouse epidermal histones by tumor-promoting agents.


An autopsy study of metastatic sites of breast cancer.


Macroautoradiographic and radiometric studies on the distribution of 3-methylcholanthrene in mice and their fetuses.


The effect of tumor size on concomitant tumor immunity.


Metabolism of human carcinoembryonic antigen in xenogeneic animals.


Evaluation of extraction procedures for the removal of  14 C-carbofuran and its toxic metabolites from cabbage leaves.


Aggregate formation in frozen aqueous solutions of nucleic acid derivatives and aromatic amino acids. Energy transfer and complex formation.


Toxic metabolites of diazinon in sheep.

Toxic metabolites of diazinon in sheep.


Microbial oxidation of 4-chloroaniline.

Microbial oxidation of 4-chloroaniline.


Tylosin-urea adduct related to tylosin stability in cattle feed.


Detection of diethylstilbestrol contamination in swine feedstuff.


Control of the synthesis of a major polypeptide of chloroplast membranes in Chlamydomonas reinhardi. The regulation of the synthesis of one of the major polypeptides of chloroplast membranes in Chlamydomonas reinhardi y-1 has been studied in order to determine what factors are involved in the control mechanism. The polypeptide is synthesized in the cytoplasm and previously was designated as c (J. K Hoober. 1972. J. Cell Biol.52:84). Under normal conditions the synthesis of polypeptide c appears to be coupled to the synthesis of chlorophyll. When greening cells are illuminated through a light filter opaque below 675 mmicro, the conversion of protochlorophyllide to chlorophyllide is blocked. Although this elimination of light below 675 mmicro, does not affect, in the main, protein synthesis in the chloroplast and cytoplasm, synthesis of polypeptide c is inhibited. Also, control cells synthesize neither chlorophyll nor polypeptide c in the dark. However, when cells are treated with chloramphenicol, an inhibitor of chloroplast protein synthesis, the synthesis of polypeptide c occurs in the absence of light required for chlorophyll synthesis. Chlorophyll per se does not appear to be required for synthesis of polypeptide c, since treating cells with hemin, maleate, or malonate causes an inhibition of the synthesis of chlorophyll but not of polypeptide c. The results of these experiments are discussed in terms of a proposed mechanism by which synthesis of polypeptide c is regulated at the transcriptional level by a precursor of chlorophyll, and this regulation is mediated by a protein or proteins synthesized within the chloroplast.


Photochemistry of mirex.

Photochemistry of mirex.


Dyrene toxicity and lack of carboxylesterase inhibition in mice and rats.


Residue studies of O,S-dimethyl phosphoroamidothioate on tomatoes.


Ribosome-membrane interaction. Nondestructive disassembly of rat liver rough microsomes into ribosomal and membranous components. In a medium of high ionic strength, rat liver rough microsomes can be nondestructively disassembled into ribosomes and stripped membranes if nascent polypeptides are discharged from the bound ribosomes by reaction with puromycin. At 750 mM KCl, 5 mM MgCl(2), 50 mM Tris.HCl, pH 7 5, up to 85% of all bound ribosomes are released from the membranes after incubation at room temperature with 1 mM puromycin. The ribosomes are released as subunits which are active in peptide synthesis if programmed with polyuridylic acid. The ribosome-denuded, or stripped, rough microsomes (RM) can be recovered as intact, essentially unaltered membranous vesicles Judging from the incorporation of [(3)H]puromycin into hot acid-insoluble material and from the release of [(3)H]leucine-labeled nascent polypeptide chains from bound ribosomes, puromycin coupling occurs almost as well at low (25-100 mM) as at high (500-1000 mM) KCl concentrations. Since puromycin-dependent ribosome release only occurs at high ionic strength, it appears that ribosomes are bound to membranes via two types of interactions: a direct one between the membrane and the large ribosomal subunit (labile at high KCl concentration) and an indirect one in which the nascent chain anchors the ribosome to the membrane (puromycin labile). The nascent chains of ribosomes specifically released by puromycin remain tightly associated with the stripped membranes. Some membrane-bound ribosomes (up to 40%) can be nondestructively released in high ionic strength media without puromycin; these appear to consist of a mixture of inactive ribosomes and ribosomes containing relatively short nascent chains. A fraction ( approximately 15%) of the bound ribosomes can only be released from membranes by exposure of RM to ionic conditions which cause extensive unfolding of ribosomal subunits, the nature and significance of these ribosomes is not clear.


Conjugated compounds in cow's milk.

Conjugated compounds in cow's milk.


Denaturation of  -chymotrypsin in frozen aqueous solutions.


Maturing pine tracheids. Organization of intravacuolar cytoplasm. The cytoplasm of the interior of maturing pine tracheids is revealed by scanning electron microscopy as a lamellate and filamentous intravacuolar reticulum immersed in vacuolar sap. Formation of cytoplasmic spherules and the breakdown of the cytoplasmic reticulum initiate protoplast disintegration that terminates in tracheid maturation. The process is believed to involve vacuolar membrane transformations.


Closure of carotid-cavernous fistula with polyurethane foam embolus. Technical note.


Tetrodotoxin sensitivity of cultured embryonic heart cells depends on cell interactions.


Catenated oligomeric circular DNA molecules from mitochondria of malignant and normal mouse and rat tissues.


Comments on Crouzon's disease and the diagnosis of arteriovenous fistula.


Carotid-cavernous fistula: a controlled embolus technique for occlusion of fistula with preservation of carotid blood flow. Technical note.


New sweetening agents: N'-formyl-and N'-acetylkynurenine.


Ocular palsy occurring with pituitary tumors.


Effect of extracranial-intracranial vascular bypass graft on experimental acute stroke in dogs.


Rates of postmortem metabolism in frozen animal tissues.


Traumatic cerebrospinal fluid fistulas in children.


Effects of prostaglandins E 1 , E 2 , A 1 , A 2 , and F 2   on canine carotid arterial blood flow, cerebrospinal fluid pressure, and intraocular pressure.


Gas chromatographic assay of the antibiotic cycloheximide.


Chromium in foods in relation to biological activity.


Comparison of electron capture and electrolytic conductivity detectors for the residue analysis of s-triazine herbicides.


Spinal cord blood flow patterns in experimental traumatic paraplegia.


Cervical intramedullary cyst due to Corynebacterium diphtheriae gravis. Case report.


Irreversible injury of cranial nerves 9 through 12 (Collet-Sicard syndrome). Case report.


Mass spectrometric identification of the hepta- and octa-chlorinated dibenzo-p-dioxins and dibenzofurans in technical pentachlorophenol.


Extravasation of angiographic contrast material from a torn middle meningeal artery into the diploi. Case report.


Sacral agenesis. Case report.

Sacral agenesis. Case report.


Intracranial foreign bodies: backfire. Report of 14 cases.


Carotid cavernous fistula: direct repair with preservation of the carotid artery. Technical note.


Treatment of the uncorrected clubfoot by triple arthrodesis.


Metatarsalgia due to biomechanical alterations of the forefoot.


Tumors and tumor-like conditions of the Os calcis.


Anatomic considerations in injuries of the calcaneus.


Axial pin fixation of fractures of the Os calcis (method of Essex-Lopresti).


Treatment of comminuted fractures of the calcaneus by triple arthrodesis.


The nonreductive treatment for fractures of the Os calcis.


Operative treatment of comminuted fractures of the Os calcis.


A technique for salvage of the infected diabetic gangrenous foot.


Neuropathy and diabetic pressure lesions.


Transmetatarsal amputations.

Transmetatarsal amputations.


The congenital rigid flatfoot. Its recognition and treatment in infants.


Intractable plantar keratosis.

Intractable plantar keratosis.


Biomechanics of the ankle: a kinematic study.


Dynamic correction of clawtoes.

Dynamic correction of clawtoes.


Studies on mono- and diiodohistidine. I. The identification of iodohistidines from thyroidal iodoproteins and their peripheral metabolism in the normal man and rat. The problem as to whether iodohistidines are normally biosynthetized in thyroglobulin and thyralbumin has been examined both in man and the rat. Evidence has been obtained for the first time that diiodohistidine (DIH) is present in both species in these two iodoproteins. The biosynthesis of monoiodohistidine (MIH) in the thyroglobulin of the normal rat has been confirmed and extended to rat thyralbumin and to human thyroid iodoproteins. THE IODOHISTIDINE IDENTIFICATION IS BASED ON FIVE ORIGINAL METHODS INCLUDING: (a) the preparation of stable and radioiodine-labeled iodohistidines; (b) the protection of the labile iodohistidines during the iodoprotein enzymatic hydrolysis; (c) the isolation of iodohistidines by ion-exchange resin chromatography; (d) their separation from each other and from iodinated cationic butanol-insoluble compounds by Sephadex G-10 chromatography; and (e) their purification by successive crystallizations to a constant specific activity. Iodohistidine levels (in percent of protein radioactivity from iodide given in vivo) were found comparable in man and the rat. However, the values (mean +/-SE) for thyroglobulin (MIH, 0.61+/-0.10%; DIH, 0.050+/-0.015%) and for thyralbumin (MIH, 2.61+/-0.57%; DIH, 0.28+/-0.09%) differ significantly (P < 0.05). Iodohistidines are stable during in vitro exposure to iodotyrosine dehalogenase preparations. In contrast to iodotyrosines the iodohistidines when given in vivo to man either orally or intravenously were in large part recovered in 24-h urines.


Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. Circulating levels of immunoreactive parathyroid hormone (PTH) were measured in 40 patients with idiopathic hypercalciuria (IH) before and during reversal of hypercalciuria with thiazide, and in four normal subjects before and during induction of hypercalciuria with furosemide. 26 patients with IH had elevated serum PTH levels. The remaining patients had normal levels. Although the correlation was not complete, high PTH levels were generally found in patients who had more severe average urinary calcium losses. When initially elevated. PTH levels fell to normal or nearly normal values during periods of thiazide administration lasting up to 22 months. When initially normal, PTH levels were not altered by thiazide. Reversal of hyperparathyroidism by thiazide could not be ascribed to the induction of hypercalcemia, since serum calcium concentration failed to rise in a majority of patients. Renal hypercalciuria produced by furosemide administration elevated serum PTH to levels equivalent to those observed in patients with IH. The findings in this study help to distinguish between several current alternative views of IH and its relationship to hyperparathyroidism. Alimentary calcium hyperabsorption cannot be the major cause of IH with high PTH levels, because this mechanism could not elevate PTH. Idiopathic hypercalciuria cannot be a variety of primary hyperparathyroidism, as this disease is usually defined, because PTH levels are not elevated in all patients and, when high, are lowered by reversal of hypercalciuria. Primary renal loss of calcium could explain the variable occurrence of reversible hyperparathyroidism in IH, since renal hypercalciuria from furosemide elevates serum PTH in normal subjects. Consequently, a reasonable working hypothesis is that IH is often due to a primary renal defect of calcium handling that leads, by unknown pathways, to secondary hyperparathyroidism.


Lower esophageal sphincter relaxation: studies on the neurogenic inhibitory mechanism. The purpose of this study was to determine the physiological mechanism of lower esophageal sphincter (LES) relaxation. Circular muscle of the esophagus, LES, and stomach were evaluated for their inhibitory response to electrical stimulation during a maintained tonic contraction produced by a superfusion of acetylcholine and physostigmine. Only the circular muscle of the distal esophagus showed an inhibitory response to electrical stimulation. The maximal inhibition of LES muscle was 63.9+/-5.9 (mean+/-SE)% of the acetylcholine produced tension and occurred at 80 V. Upper esophageal and gastric muscle were not inhibited. The inhibitory response of the LES muscle was antagonized by tetrodotoxin and hexamethonium but not by other specific antagonists. Adrenergic nerve destruction following 6-hydroxydopamine also did not abolish the LES inhibition. These data indicate that the distal esophagus, at the zone of the manometrically determined LES, is characterized by a nonadrenergic neural inhibitory system. We suggest that these nerves may mediate LES relaxation.


Some characteristics of the rabbit vermiform appendix as a secreting organ. It has been confirmed that the rabbit vermiform appendix secretes spontaneously at a relatively rapid rate (1-12 ml.h(-1); 1.4+/-0.24 mul.min(-1).cm(-2)). The electrolyte composition is similar to that of ileal fluids and independent of the secretory rate. The transmural potential difference is about 12 mV, mucosa negative. Of the major electrolytes, only HCO(3) (-) is secreted grossly against its electrochemical potential difference. This finding plus the low hydraulic (or osmotic) permeability (L(p)) and high secretory pressures of the organ strongly suggest that the secretion is an active one. The passive permeability to Na(+) and Cl(-) appears to be, at most, somewhat less than for small bowel. Permeability to mannitol was estimated at 2.5 x 10(-7) cm.s(-1). On the basis of reasonable assumptions and results with luminal test solutions of differing osmolarities, it was concluded that (a) the L(p) of the appendiceal epithelium is in the lower range of values reported for small bowel and colon; (b) the L(p) is higher for osmotic absorption than for osmotic secretion; and (c) the rate of spontaneous secretion is insensitive to luminal anisotonicity over a wide range of values. But sufficiently hypotonic solutions can reverse net secretion to net absorption, more by inhibiting spontaneous secretion than increasing osmotic absorption. The rabbit vermiform appendix appears to be a useful model for the elucidation of intestinal secretory processes.


Quantitative importance of changes in postglomerular colloid osmotic pressure in mediating glomerulotubular balance in the rat. In recent studies in this laboratory employing normal hydropenic rats we have demonstrated that the reduction in absolute proximal reabsorption that attends the experimental reduction of single nephron glomerular filtration rate (SNGFR) (glomerulotubular balance) is mediated, at least in part, by the accompanying decline in postglomerular vascular protein concentration, and therefore, postglomerular colloid osmotic pressure (piEA). The present study was undertaken to define the quantitative contribution of these changes in piEA to the changes in absolute proximal reabsorption measured under these conditions. A protocol was employed which enabled us to examine the effects on absolute proximal reabsorption of reductions in filtered load brought about under conditions in which piEA remained essentially unchanged. Thus, after partial aortic constriction in 16 plasma-loaded rats, near constancy of piEA was observed in 10 (a change in efferent arteriolar protein concentration of 0.4 g/100 ml or less) and in these, uniform reductions in SNGFR averaging 16.7 nl/min were attended by reductions in absolute proximal reabsorption averaging only 1.7 nl/min, or 7% of preconstriction values. These findings, taken together with previous observations from this laboratory, suggest that the proximal reabsorptive adjustment that characterizes glomerulotubular balance in the rat is markedly blunted when changes in piEA are prevented. In the remaining six rats, a mean reduction in filtered load comparable to that observed in the above group was attended by slightly to moderately greater reductions in efferent arteriolar protein concentration, thereby fulfilling less well the stated aim of this study. Nevertheless, in accord with the above conclusion, these relatively greater reductions in piEA were accompanied by correspondingly greater reductions in absolute proximal reabsorption.


Movement of the feline esophagus associated with respiration and peristalsis. An evaluation using tantalum markers. The outer, lateral esophageal walls in the distal half of the esophagus in each of five cats were labeled with small tantalum wires. About 8 wk later, esophageal motion associated with respiration and peristalsis, induced by injecting barium boli (5 ml each) into the proximal esophagus, was recorded on cine and serial biplane roentgenograms while recording intraluminal esophageal pressures simultaneously by manometry. Esophageal motion was also evaluated without a manometric tube in place. The coordinates for each marker were digitized and a computer was used to plot marker position against time. During respiration, the markers passively made a shallow, 2-10 mm excursion on the longitudinal esophageal axis. This movement was synchronous with thoracic and diaphragmatic movement and changes in intraluminal esophageal pressure. Immediately after the onset of peristalsis, the markers made a pronounced oral movement of 10 mm or more above their mean respiratory position, as if to engulf the bolus. Markers in opposing esophageal walls approximated one another and commenced an aboral movement as the bolus tail, which was essentially co-incident with onset of the manometric pressure complex, passed the marker sites. The markers returned to their respective rest positions essentially coincident with passage of the pressure complex peak and then moved below their respective rest positions. The aboral excursion occurred predominantly after the bolus had emptied into the stomach. The magnitude and duration of oral excursion was significantly greater for the distal than for the more proximal markers; conversely, the magnitude and duration of aboral excursion was greater for the proximal than for the more distal markers. During the peristaltic sequence, the labeled portion of the esophagus shortened from 26 to 46% of its resting length. No evidence of esophageal torque was shown. These findings suggest that both the longitudinal and circular esophageal musculature play an active and important role during peristaltic transport of a bolus through the esophagus.


Neural regulation of insulin secretion in the dog. The effects of stimulation of the mixed autonomic nerve to the dog pancreas has been studied under conditions in which both pancreaticoduodenal vein blood flow and insulin concentration were determined. Stimulation resulted in increased insulin output, which was blocked by prior administration of atropine. Blood flow was reduced by stimulation in proportion to the rate of stimulation. At 40 stimuli/s a maximum effect was found at 1 min with a gradual return toward base line despite continued application of the stimulus. Atropinization had no effect on blood flow changes. Insulin responses to 0.1 g/kg glucose were reduced on the average 40% by simultaneous stimulation of the pancreatic nerve at 40 cycles/s in atropinized animals. These studies establish this preparation as a reproducible model for the direct examination of autonomic influences on endocrine pancreatic function. From them it is concluded that the nerve supply to the endocrine pancreas of the dog is sufficient to inhibit insulin secretion by activation of the sympathetic nerves and to stimulate insulin secretion by activation of the parasympathetic nerves.


Effects of sugars and amino acids on sodium and potassium influx in rabbit ileum.


Homocystinuria: heterozygote detection using phytohemagglutinin-stimulated lymphocytes. Deficiency of cystathionine synthase activity results in the clinical syndrome of homocystinuria. Using phytohemagglutinin (PHA)-stimulated lymphocytes as a readily available source of this enzyme, its activity has been compared in 48 control subjects, seven homozygotes affected with homocystinuria, and 17 obligate heterozygotes. PHA-induced enzyme levels were highest in controls (mean +/-SEM, 666.9+/-70.2 pmol cystathionine formed/mg protein per 4 h), intermediate in heterozygotes (114.4+/-27.3), and absent to severely deficient in homozygotes (2.0+/-1.6). Since only three of the 17 values from the obligate heterozygotes overlapped into the control range, this simple method may become clinically useful for heterozygote detection of carriers of the gene for abnormal cystathionine synthase. In addition, this system for induction of cystathionine synthase in lymphocytes has a more general relevance to human biochemical genetics in that it demonstrates that the absence of an enzyme in a normal cell does not preclude using that source for diagnosis of genetic disease if the enzyme can be induced.


Renal response to chronic intravenous salt loading in the rat. The natriuresis of acute Ringer's loading is associated with a rise in the rate of delivery of fluid beyond the proximal tubule due both to a rise in glomerular filtration and a fall in absolute reabsorption, the latter being causally mediated, at least in part, by the accompanying fall in postglomerular vascular [protein]. To determine whether these factors also contribute to the renal response to chronic Ringer's loading, nine rats given continuous infusions, 30% body weight/day over 5-14 days, were studied using free-flow micro-puncture techniques. Results were compared with data from 10 chronic control rats given less than 1.5% body wt/day. Late proximal tubule fluid-to-plasma [inulin] ratios, (TF/P)(IN), single nephron glomerular filtration rate (SNGFR), absolute proximal reabsorption, and postglomerular vascular [protein] in chronic control rats and chronically loaded rats averaged 2.2+/-SE 0.1 (n = 35) and 1.5+/-0 (35), P<0.001; 37+/-2 (35) and 47+/-4 nl/min (35), P<0.05; 19+/-1 (35) and 16+/-2 nl/min (35), P>0.2; and 9.5+/-0.3 (8) and 8.6+/-0.3 g/100 ml (8), P>0.05, respectively. Thus the fall in (TF/P)(IN) and the rise in distal delivery during chronic Ringer's loading were due almost entirely to the rise in SNGFR, and not to any large fall in absolute reabsorption. Hence chronic and acute Ringer's loading increase delivery of proximal tubule fluid by different mechanisms, with chronic sodium homeostasis being governed overwhelmingly by adjustments in GFR. When, however, an acute Ringer's load was infused into chronically loaded rats, we observed significant and parallel reductions in absolute proximal reabsorption and postglomerular vascular [protein]. These findings suggest that the difference between the effects of chronic vs. acute Ringer's loading on absolute proximal reabsorption may have been due, at least in part, to the corresponding difference in the effects these two loading procedures have on postglomerular vascular [protein].


Mechanism of the redistribution of renal cortical blood flow during hemorrhagic hypotension in the dog. Studies were performed to define the mechanisms involved in the redistribution of renal cortical blood flow to inner cortical nephrons which occurs during hemorrhagic hypotension in the dog. The radioactive microsphere method was utilized to measure regional blood flow in the renal cortex. Renal nerve stimulation decreased renal blood flow 40% but had no effect on the fractional distribution of cortical blood flow. Pretreatment with phenoxybenzamine, phentolamine, propranolol, or atropine did not alter the redistribution of cortical flow during hemorrhage. A reduction in renal perfusion pressure by aortic constriction caused a qualitatively similar alteration in regional blood flow distribution as occurred during hemorrhage. When perfusion pressure was kept constant in one kidney by aortic constriction followed by hemorrhage, no redistribution occurred in the kidney with a constant perfusion pressure while the contralateral kidney with the normal perfusion pressure before hemorrhage had a marked increase in the fractional distribution of cortical flow to inner cortical nephrons. Additionally, retransfusion had no effect on the fractional distribution of flow in the kidney in which perfusion pressure was maintained at the same level as during hemorrhage while in the contralateral kidney in which pressure increased to normal there was a redistribution of flow to outer cortical nephrons. These studies indicate that the redistribution of renal cortical blood flow which occurs during hemorrhage is not related to changes in adrenergic activity but rather to the intrarenal alterations which attend a diminution in perfusion pressure.


Lingual lipase and its role in the digestion of dietary lipid. The serous glands of rat tongue were found to contain a potent lipolytic enzyme which hydrolyzed triglyceride to mostly diglyceride and free fatty acids (FFA) at pH 4.5-5.4. Homogenates of lingual serous glands from adult rats hydrolyzed 40-70 mmol of triglyceride/g per h. The soft palate, anterior oral pharyngeal wall, and lateral oral pharyngeal glands also contained the activity, but at a much lower level. The lipolytic activity was also found in saliva collected through an esophageal cannula and in stomach contents of rats fed a fat-rich meal. The stomach contained very little activity, however, when saliva was excluded. Lipolytic activity was not found in the stomach wall or in the parotid, submandibular, and sublingual glands. The findings suggest that the lingual serous glands secrete a lipase which catalyzes in the stomach the conversion of triglyceride to partial glycerides and FFA. It is proposed that this reaction is the first step in the digestion of dietary lipid.


Erythropoietic porphyria of the fox squirrel Sciurus niger. Uroporphyrin I is found in high concentration in the bones, teeth, blood, soft tissues, and urine of the fox squirrel, Sciurus niger. The concentration of uroporphyrin in fox squirrel spleen is much higher than in liver, kidney or bone marrow, probably because of accumulation from phagocytosed red cells. Bleeding causes a marked increase in the uroporphyrin concentration of red cells and spleen, and a 3-8-fold increase in uroporphyrin excretion. Urinary excretion of delta-aminolevulinic acid and porphobilinogen is not greater in fox squirrels than in nonporphyric gray squirrels. Sciurus carolinensis, used as controls. In all these characteristics, as well as in the previously demonstrated deficiency of the enzyme uroporphyrinogen III cosynthetase in red cells, the physiological porphyria of fox squirrels resembles congenital erythropoietic porphyria, a hereditary disease of man and cattle. For squirrels differ in showing no evidence of cutaneous photosensitivity or hemolytic anemia. Uroporphyrinogen III cosynthetase activity is present in fox squirrel bone marrow at 1/10 its concentration in gray squirrel marrow. The fox squirrel enzyme is much more unstable than the gray squirrel enzyme, which provides a possible explanation for its low activity and for the overproduction of uroporphyrin I. It is unlikely that the deficiency of cosynthetase is due to its inactivation by excessive amounts of uroporphyrinogen I synthetase, because activity of the latter enzyme is the same in blood from fox and gray squirrels.Fox squirrel porphyria provides a convenient model for studies of pathogenesis of human congenital erythropoietic porphyria.


SCL-90: an outpatient psychiatric rating scale--preliminary report.


Availability of psychotropic compounds as reference standards.


Letters: Requirements for testing of hypotheses about molecular coding of experience: transfer studies.


Effects of tachycardia on the function of the Starr-Edwards mitral ball valve prosthesis.


Pacemaker longevity.

Pacemaker longevity.


Later results of closure of secundum atrial septal defect in children.


Adaptation to high altitude hypoxia as a factor preventing development of myocardial ischemic necrosis.


Comparison of heart size and serum concentration as determinants of digoxin tissue concentration in the normal and hypertrophied rabbit heart.


Comparison of atrial and ventricular drive on sinus nodal function in the dog.


Experimental production of hypoplastic left heart syndrome in the chick embryo.


Longitudinal study of the standard electrocardiogram in the healthy premature infant during the first year of life.


Echocardiographic studies to explain opening snaps in presence of nonstenotic mitral valves.


Intermittent trifascicular block. Different mechanisms of conduction disturbances in the bundle branches.


Intrapulmonary veno-occlusive disease.

Intrapulmonary veno-occlusive disease.


Supravalvular stenosing ring of the left atrium associated with corrected transposition of the great vessels.


Atrial septal defect in adults. Clinical and hemodynamic results of surgery.


Hypomagnesemia and refractory cardiac arrhythmia in a nondigitalized patient.


Decreased intensity of closure sound in a normally functioning Starr-Edwards mitral valve prosthesis. Observations on presystolic mitral valve closure.


Absorbed dose and tissue dose.

Absorbed dose and tissue dose.


Philosophy and occupational therapy.

Philosophy and occupational therapy.


A modified scintillation cell for the determination of radon in uranium mine atmosphere.


Occupational therapy: a model for the future.


Beta ray dose distributions near an interface.


Comment on the rap, a proposed unit for diagnostic x-ray protection.


Counting of small  137 Pm-activities in faecal ashes.


Theoretical radiation dose to the human system from assimilated tritium.


New values for epidermal thickness and their importance.


Meeting health needs.

Meeting health needs.


A dynamic finger splint.

A dynamic finger splint.


Corset-type elbow restraints.

Corset-type elbow restraints.


Deposition of  85 Kr and tritium released from a nuclear fuel reprocessing plant.


Fingerpainting. Relationships of picture content and patient's age and diagnosis to color choice.


Gamma ray dose in a cylindrical phantom.


Comparative effects of potassium, acetazolamine, furosemide, thyrotropin and thyroxne on  137 Cs retention in the rat.


The Steverson sling for the flaccid hemiplegic.


Uses of the proximal interphalangeal joint gutter splint.


Spectra of scattered diagnostic x-rays from an Alderson phantom.


Response of NTA personnel neutron monitoring film worn on human phantom.


Psychotherapeutically oriented rehabilitation in chronic mental illness.


Environmental radiation background variations between residences.


Attenuation of radiation in tunnels penetrating the shield of an extracted beam of the 7 GeV proton synchrotron Nimrod.


Organizational aspects of a personnel dosimetry service.


SEBEACH, a digital computer program for the estimation of body content of plutonium from urine data.


Selenium retention in tissues and sperm of rats fed a Torula yeast diet.


Cellular growth during prenatal and early postnatal periods in progeny of pyridoxine-deficient rats.


Effect of amino acids on ribosome aggregation and protein synthesis in perfused rat liver.


Essentiality of vitamin C in feeds for intensively fed caged channel catfish.


Enhancement of iron absorption from ligated segments of rat intestine by histidine, cysteine, and lysine: effects of removing ionizing groups and of stereoisomerism.


Vitamin A contamination in commercial stabilized vitamin E.


Liver storage of vitamin A in rats fed carotene stereoisomers.


Further studies on the availability of the fluoride in fish protein concentrate.


Influence of feeding DEAE Sephadex on growth, lactation and lipid utilization in the rat.


Lysine deficiency in the rat: concomitant impairement in carnitine biosynthesis.


Effect of DEAE Sephadex on liver vitamin A of lactating rats and their offspring.


Effect of S-methylcysteine sulfoxide, S-allylcysteine sulfoxide and related sulfur-containing amino acids on lipid metabolism of experimental hypercholesterolemic rats.


Influence of dietary cholesterol and cholic acid on liver carbohydrate metabolism enzymes in rats.


Intermittent myocardial ischemia during cardiopulmonary bypass.


The surgical management of intracardiac defects due to penetrating trauma.


Unusual sequel to operative intervention for vascular ring.


The autologous rectus sheath cardiac valve. 3. Design and physical properties.


Mediastinal bronchial-type adenoma.

Mediastinal bronchial-type adenoma.


Asymptomatic solitary pulmonary nodules. Host survival, tumor size, and growth rate.


Elongation and exteriorization of the coronary sinus: surgical technique in laboratory animals. Preliminary report.


Intracranial metastasis from cancer of the lung. A prospective study of the diagnostic validity of positive and negative findings in neurological examination, electroencephalography,  99m Tc brain scanning, and lumbar puncture before thoracotomy.


Long-term evaluation of aortic valvuloplasty for aortic insufficiency and ventricular septal defect.


Perforation of the esophagus. A 30 year review.


The pulmonary artery after debanding.

The pulmonary artery after debanding.


Total correction of tetralogy of Fallot in infancy.


Open-heart surgery in the first year of life.


The Rastelli operation. Its indications and results.


Surgical management of lymphatic tumors of the mediastinum in children.


Diagnosis and decision making.

Diagnosis and decision making.


Hyperparathyroidism due to clear cell hyperplasia. Serial determinations of serum ionized calcium, parathyroid hormone and calcitonin.


The echocardiogram in left atrial myxoma.


Essential hypertension--why idiopathic?

Essential hypertension--why idiopathic?


Nonbacterial thrombotic endocarditis in patients with malignant neoplastic diseases.


Significant associations of adrenal cortical abnormalities with "essential" hypertension.


Hypoproteinemia, splenomegaly, ascites and disseminated histoplasmosis.


Pericardial tamponade: a major presenting manifestation of hydralazine-induced lupus syndrome.


Calcium, phosphorus, and magnesium metabolism following head injury.


Familial malignant melanoma.

Familial malignant melanoma.


Regional lymphatics and cancer immunity.


Pulmonary reimplantation response.

Pulmonary reimplantation response.


Pulmonary artery catheterization in critically ill surgical patients.


Blood flow measurements during repair of a right coronary artery superior vena cava fistula.


Blunt trauma rupture of the heart.

Blunt trauma rupture of the heart.


Diverticular disease in the transposed colon used for esophagoplasty: report of two cases.


Response of the interposed human colonic segment to an acid challenge.


The sympathetic response in head trauma; catecholamine and cardiopulmonary changes upon altering p CO 2 .


Arteriovenous malformations of the scalp.


A new sign of favorable prognosis in mammary cancer: hyperplastic reactive lymph nodes in the apex of the axilla.


Preoperative localization of hyperfunctioning parathyroid tissue: radioimmunoassay of parathyroid hormone in plasma from selectively catheterized thyroid veins.


The genetics of a dominant inhibitor of the Lutheran antigens.


Studies on the agglutinin accompanying the warm haemolysin active against trypsinized red cells.


The action of seed and other reagents on En(a-) erythrocytes.


Separation of platelet rich plasma and red cells with modified gelatin.


A modified container for liquid nitrogen preservation of an erythrocyte test cell panel.


WHO-FAO programme on comparative virology.


Prevention of blindness.

Prevention of blindness.


The prevention of xerophthalmia.

The prevention of xerophthalmia.


Evaluation of public health programmes.

Evaluation of public health programmes.


Health planning in national development.


Training of medical teachers in pedagogy.


Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza.


Physical anthropology and the biobehavioral approach to child growth and development.


Height and weight growth patterns of school age deaf children.


Arm lengths and arm reaches: some interrelationships of structural and functional body dimensions.


Microevolutionary change in Arikara Crania: a multivariate analysis.


Economic impact on postnatal ossification.


Albumin Mexico (Al Me ) in the Guatemalan highlands.


Genetic and socio-cultural differentiation in the aborigines of Arnhem Land, Australia.


Structure of bone in the skulls of Neanderthal fossils.


On recent actions and plans of the FDA relevant to the management of patients with allergic disease.


Epidermolytic variant of solar keratosis.


Zosteriform keratosis follicularis cleared with topically applied vitamin A acid.


Poikiloderma atrophicans vasculare associated with muscular dystrophy.


The heroin ulcer. New addition to the differential diagnosis of ulcers of the penis.


Familial cold urticaria.

Familial cold urticaria.


Kaposi's sarcoma in community practice.

Kaposi's sarcoma in community practice.


Basal cell carcinoma.

Basal cell carcinoma.


Erythema Multiforme.

Erythema Multiforme.


Presidential address for the Dermatology Foundation.


Follicular eruptions of atopic dermatitis.


Eccrine-centered nevus.

Eccrine-centered nevus.


Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum.


Digitate dermatosis. A new look at symmetrical, small plaque parapsoriasis.


Infection of toe webs by gram-negative bacteria.


Trichonodosis.

Trichonodosis.


Multiple basal cell epitheliomas with sebaceous differentiation.


Spread of tumors to the skin.

Spread of tumors to the skin.


Focal epithelial hyperplasia. Report of two cases from Israel and review of literature.


Primary cutaneous plasmacytoma.

Primary cutaneous plasmacytoma.


Varieties of hemiplegic migraine.

Varieties of hemiplegic migraine.


Progesterone suppositories and pessaries in the treatment of menstrual migraine.


Cryosurgery of migraine.

Cryosurgery of migraine.


The haemodynamics of migraine--a review.


Prevalence and heredity of migraine and migrainoid headaches among 461 Danish doctors.


Alcohol, alcoholism, the social drinker and the hangover.


A modified semi-micro method for the test for leptospirosis.


Transcutaneous measurement of arterial wall properties as a potential method of estimating aging.


Comments on the use of anticoagulants in geriatric patients.


Welfare emotions and family therapy in geriatrics.


Diverticulitis in the elderly.

Diverticulitis in the elderly.


Hypoferremia in acute myocardial infarction.


Ileo-colic intussusception with villous tumors in a 93-year-old woman.


Methyldopa-hydrochlorothiazide therapy in hypertensive geriatric patients.


Clinical and physiological effects of stimulation of the paleocerebellum in humans.


Arterial oxygen tension in relation to age in hospital subjects.


Pricing pharmaceutical service--art, science or whim.


Application of cost-effectiveness analysis to patient record systems.


The free health center concept and pharmacy services.


The role of the director of pharmaceutical services in a comprehensive health care program.


Allopurinol-mercaptopurine interaction.

Allopurinol-mercaptopurine interaction.


Evidence sought.

Evidence sought.


Protecting our professional prerogatives.


Where the profession is goint with drug product selection.


Pharmacists' essential role in autotherapy.


Criteria for considering equivalence.

Criteria for considering equivalence.


Politics of prescription drug advertising.


Who shall establish drug standards?

Who shall establish drug standards?


"Clinical" pharmacy.

"Clinical" pharmacy.


Determining a dispensing fee by cost accounting methods.


Infectious hepatitis after ingestion of raw clams.


Hamartoma of the hepatic bile ducts.

Hamartoma of the hepatic bile ducts.


Melanomatous meningiomas.

Melanomatous meningiomas.


Acute perforating diverticulitis. Emergency surgical treatment.


Colistin toxicity. Neuromuscular and renal manifestations. Two cases treated by hemodialysis.


A pedunculated cyst of the heart.

A pedunculated cyst of the heart.


Liticogenic disease.

Liticogenic disease.


The technological challenge.

The technological challenge.


Insertion of intrauterine devices in the early postpartum period.


Traumatic spondylolisthesis.

Traumatic spondylolisthesis.


Hypersexual behavior complicating levodopa (I-dopa) therapy.


Polycythemia vera with acute Budd-Chiari syndrome.


The anxiety-ridden patient in office practice.


The physician associate program of the University of Minnesota Medical School.


Clinical use of blood levels of cardiac drugs.


Radiation-induced chromatid aberrations in the bone marrow and lymph nodes of the rat during the first 24 h after irradiation.


The effect of x-rays on labelling pattern of M 1  and M 2  chromosomes in Chinese hamster cells.


Increased sensitivity of xeroderma pigmentosum cells to some chemical carcinogens and mutagens.


Chromosome damage to HeLa cells grown continuously in caffeine.


A table for the estimation of the spontaneous mutation rate of cells in culture.


The development of radioresistance in irradiated Drosophila nebulosa populations.


A comparison of mutation induction by 14 MeV fast neutrons and  137 Cs  -rays in meiotic spermatocytes in the silkworm.


The mutagenic effect of repeated small radiation doses to mouse spermatogonia. 3. Does repeated irradiation reduce translocation yield from a large radiation dose?


Dominant lethal effects of triflupromazine in hybrid C3D2F 1 -J mice.


An assessment of the effects of mercury on the meiosis of mouse ova.


Electrocautery treatment of cervical intraepithelial neoplasia.


Treatment of stage I carcinoma of the cervix.


Megestrol acetate in the management of advanced endometrial carcinoma.


The 1971 in-training examination in obstetrics and gynecology.


Multiple publication.

Multiple publication.


Coping with family planning in a rural area.


Mycoplasma hominis type I infection and pregnancy.


Pneumothorax complicating amniocentesis.


The effect of ultrasound on human chromosomes in vitro.


Compound presentation of the fetus.

Compound presentation of the fetus.


The treatment of large condylomata acuminata complicating pregnancy.


Relief for Herpes vulvitis.

Relief for Herpes vulvitis.


Hemophilus vaginalis septicemia.

Hemophilus vaginalis septicemia.


Perforation of the uterus with a shield intrauterine device.


Intrapartum fetal monitoring. Maternal and fetal morbidity and perinatal mortality.


Giant cervical polyp.

Giant cervical polyp.


Communication between the public and the dental profession.


The application of a model for health care services in a rural setting.


Changing state laws regulating health manpower.


Health educators.

Health educators.


Low birth weight infants.

Low birth weight infants.


International food festival--a community action program.


Tuberculosis outbreak in a circus: report of a cooperative investigation.


Agencies in cities in crisis: a descriptive study of selected characteristics.


A study of services and needs of teenage pregnant girls in the large cities of the United States.


The family health worker revisited: a five-year follow-up.


A retrospective analysis of the Haight-Ashbury free dental clinic.


Priorities in health care: the consumer's viewpoint in an Appalachian community.


Cerebral complications in juvenile rheumatoid arthritis.


Gynecological hazards of water-skiing.

Gynecological hazards of water-skiing.


Problems in selection of topical anti-inflammatory corticosteroids. Desonide, a non-fluorinated topical corticosteroid (16-alpha-hydroxyprednisolone acetonide), is compared with its fluorinated analogue, triamcinolone acetonide, as to vasoconstriction ability and epidermal penetration rate. Clinical effectiveness of desonide is further assessed by means of a double-blind paired comparison with an accepted potent fluorinated steroid, betamethasone 17-valerate. It is demonstrated that fluorination of the steroid molecule is not necessary to achieve potent topical anti-inflammatory effect. Vasoconstriction and epidermal penetration are not enhanced by fluorination in the drugs studied.


Ligation of hemorrhoids as an office procedure. Hemorrhoidectomy has been done on all our patients in whom operation was indicated, using the ligation method in the office. The patient does not require hospitalization or general anesthesia and rarely has pain or loss of time from work. Many thousands of hospital bed-days have been saved for more serious problems. The results of the treatment of our first 1000 patients have been very satisfactory.


An improved radiological method for the evaluation of Achilles tendon xanthomatosis. Xanthomatous infiltration of tendons is a clinical feature common to many cases of hyperlipidemia. The xanthomas can be detected and only grossly assessed by palpation. This report describes a radiological technique used to assess these lesions at the Achilles tendon level. The "mammography technique" applied to the study of Achilles tendons was used in 32 normolipemic subjects and 32 hyperlipidemic patients. Both tendons could be observed in their entire length and their thickness, greatly increased in xanthomatosis, could be accurately measured. The results of this survey suggest that the radiological approach may provide a useful tool for the routine evaluation and follow-up of tendon xanthomas.


The infection hazard of contaminated nebulizers. Ineffectual disinfection of inhalation equipment between therapy sessions of different patients has been reported to produce serious outbreaks of infection. The role of properly disinfected equipment that becomes colonized during use was assessed. In the Vancouver General Hospital gram-negative bacilli in the nebulizer water were demonstrated in 10.5% of nebulizers being used for periods of 24 to 72 hours. In at least 15% of patients exposed to contaminated nebulizers the organism was recovered from the respiratory tract 48 hours after removal of the equipment. Only one out of 85 patients exposed to contaminated nebulizers developed pneumonia, and in this instance a clear history of aspiration of vomitus was present. The low incidence of pneumonia may be related to the high percentage of nebulizers contaminated by organisms of low virulence and might be much greater in hospitals where more highly pathogenic organisms are commonly found as nebulizer contaminants. Fifteen patients with pneumonia prior to exposure to a contaminated nebulizer failed to show any evidence of superinfection.


Familial hyperlipoproteinemia in an isolated part of Newfoundland. Eleven cases of ischemic heart disease with or without myocardial infarction from two families in the Baie Verte Peninsula, Newfoundland, were studied. All were found to have hyperlipoproteinemia of the familial types. The family trees were traced and a definite genetic pattern detected. Diets were found to be rich in saturated fats, salt and carbohydrates. It is suggested that detection of similar families may play a significant role in the field of preventive medicine.


The technique of subclavian vein cannulation. A modification of the technique for subclavian vein cannulation, which avoids the risk of fatal air embolism, is described. Other essential precautions designed to avoid the usual complications are emphasized. The technique as described has been used successfully in over 50 consecutive cases without complications.


Congenital varicella associated with multiple defects. Only two previous reports in the medical literature record the association of multiple congenital defects in the baby and varicella in the mother during the first trimester of pregnancy.The case is reported of a female infant born to a mother who contracted varicella in the 11th week of pregnancy. The infant was premature, small for dates, and had skin and localized muscular defects and respiratory difficulty. Subsequently she was found to be retarded. She failed to thrive and was subject to frequent infections. Further investigation revealed a unilateral diaphragmatic weakness, scoliosis and abnormalities of the ocular fundi. Several non-febrile seizures occurred. A pneumoencephalogram revealed dilated ventricles. She died at 20 months of age following a seizure.Consideration of maternal infections, especially viral, occurring early in pregnancy, augmented by antibody studies in the newborn and mother should be part of the investigation of multiple congenital defects in the newborn.


How the federal government's amphetamine controls will work.


Topical corticosteroids.

Topical corticosteroids.


Effect of vitamin A on epithelial morphogenesis in vitro.


Circadian rhythm of nuclear DNA in adult rat liver.


Lack of expression of differentiation in mouse teratoma-fibroblast somatic cell hybrids.


Localization of DNA-dependent RNA polymerase activities in fixed human fibroblasts by autoradiography.


Increased transport of 2-aminoisobutyric acid in rat lymphocytes stimulated with concanavalin A.


Estimation of the proportion of cell nuclei in tissue sections falling within tritium-autoradiographic range.


Osteoclasis; a discussion.

Osteoclasis; a discussion.


Your tattletale office and what it says.


Biomechanical examination of the foot.

Biomechanical examination of the foot.


Iatrogenic, corticosteroid-induced acrodermatitis chronica atrophicans.


A total stereoselective synthesis of myo-, allo, neo-, and epi-inositols.


Sterol metabolism. XX. Cholesterol 7 -hydroperoxide.


The synthesis of N-acyl- -mercaptoalanine derivatives.


Reaction of hexafluoroacetone with certain simple peptides and related compounds.


New phenolic Hasubanan alkaloids from Stephania abyssinica.


Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica.


Psychobiological characteristics in youth as predictors of five disease states: suicide, mental illness, hypertension, coronary heart disease and tumor.


Observations and management of malignant pleural effusions in breast carcinoma.


Infundibular pulmonic stenosis with intact ventricular septum in the adult.


The Edwards A. Park Building. A description.


Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age.


Pyloric-sphincter dysfunction in patients with gastric ulcer.


Ventricular conduction blocks and sudden death in acute myocardial infarction. Potential indications for pacing.


Elevated plasma dopamine-beta-hydroxylase activity in autosomal dominant torsion dystonia.


Alleged psychogenic disorders in women--a possible manifestation of sexual prejudice.


Natural science.

Natural science.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-1973.


Breakdown of barriers in gastric ulcer.

Breakdown of barriers in gastric ulcer.


Who me--a sexist?

Who me--a sexist?


Sickle-cell programming--an imperiled promise.


Rabies in Massachusetts--eleven years in retrospect.


Defective release of growth hormone in parkinsonism improved by levodopa.


DNCB--reactivity and skin irritation.

DNCB--reactivity and skin irritation.


Is there more than one parathyroid hormone?


Discordance in acute leukemia.

Discordance in acute leukemia.


Remote effects of benign neoplasms.

Remote effects of benign neoplasms.


Sudden-infant-death syndrome.

Sudden-infant-death syndrome.


Inoculation vaccinia--a hazard of the conjugal bed.


Gonorrheal proctitis.

Gonorrheal proctitis.


B(ureaucratic) block of propranolol.

B(ureaucratic) block of propranolol.


Heart-warming procedure.

Heart-warming procedure.


Barbiturates for "insomnia"?

Barbiturates for "insomnia"?


Salivary electrolytes and digitalis intoxication.


To practice good medicine these facts important too.


Strike. Or--why not to join a union.

Strike. Or--why not to join a union.


This campaign needs us.

This campaign needs us.


From Asia securinine--a central nervous stimulant is used in treatment of amytrophic lateral sclerosis.


Laryngeal carcinoma.

Laryngeal carcinoma.


Acute pulmonary edema. I.

Acute pulmonary edema. I.


Abdominal hernias associated with small intestinal obstruction.


Normal chest excursion.

Normal chest excursion.


A rapid cooling device for controlled cutaneous stimulation.


Wheelchair seat board for use with spica cast.


Effectiveness of functional training, active exercise, and resistive exercise for patients with hemiplegia.


Mat walker for paraplegic rehabilitation.


Manipulative therapy in physical therapy curricula.


Theses and dissertations.

Theses and dissertations.


Licensure examination in physical therapy.


Another journal: Raw data in research articles?


How should a physical therapist handle a request that treatment be continued even though treatment goals have been reached?


Microaneurysms of the carotid artery after "non-traumatic" percutaneous puncture.


Angiographic findings in the Tolosa-Hunt syndrome: painful ophthalmoplegia.


Angiographic demonstration of Kugel's artery (arteria anastomotica auricularis magna).


Angiographic demonstration of fenestrations of the intradural intracranial arteries.


Practical use of medium and slow-speed screens for cerebral angiography.


The borderline scinticisternogram.

The borderline scinticisternogram.


A radiological approach to the patient with acute, extensive bowel ischemia.


The use of radionuclide studies in the prediction of function in renal failure.


Isolated thoracic dysostosis.

Isolated thoracic dysostosis.


Epiphyseal involvement in polyostotic fibrous dysplasia. A report of two cases.


Opacification of retrosternal lymph nodes following barium peritonitis. Report of two cases.


Spherical pneumonias in children simulating pulmonary and mediastinal masses.


Evaluation of 16-mm cinè cystourethrography in children: method and dosimetry.


Echocardiographic diagnosis of transposition of the great vessels.


Combined compensation for contours and heterogeneity.


A new method for computer generation of dose distributions from external x- and gamma-ray sources.


Radiation injury to large arteries. 3. Further examples with prolonged asymptomatic intervals.


A practical method for correcting the primary component of the field of a 60Co irradiator at off-axis points.


A photon scattering technique for the measurement of absolute bone density in man.


Efficacy of 32P and 198Au in the treatment of Ehrlich ascites tumor in mice.


Retrograde venography of subcutaneous arteriovenous fistulas created surgically for hemodialysis.


Survey of training of therapeutic radiologists in the United States.


The problem of differentiating benign antral ulcers from intramural tumors.


Carcinoma in the porcelain gallbladder.

Carcinoma in the porcelain gallbladder.


Vascular endoscopy.

Vascular endoscopy.


Cholesterol embolization.

Cholesterol embolization.


Inhibition of thrombosis on vascular catheters in cats.


Complete interruption of the aortic arch in adults.


Nonspecificity of abnormal vascularity in the angiographic diagnosis of malignant neoplasms.


Bronchial brush biopsy in lung cavities.


Atraumatic aseptic necrosis of the talus.


Metastatic fat necrosis and lytic bone lesions in a patient with painless acute pancreatitis.


Viseodisc storage of radiographs. Its uses and limitations.


Apparent temperature degradation in thermograms of human anatomy viewed obliquely.


The one-week prevalence of symptoms in neurotic patients and normals.


Goal-attainment scaling as a method for evaluating mental health programs.


The behavior of chimpanzees in their natural habitat.


Schizophrenia: a family's projective identification.


The private practice of community psychiatry.


Problems associated with the introduction of a psychiatric unit into a rural general hospital.


Therapeutic abortion and a prior psychiatric history.


Hospital treatment of borderline patients.


Psychiatric screening with automated multiphasic health testing in the VA admission procedure.


Factors in the description and grouping of alcoholics.


Rubidium: biochemical, behavioral, and metabolic studies in humans.


Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness.


Biological psychiatry.

Biological psychiatry.


L-dopa, dopamine, and hypomania.

L-dopa, dopamine, and hypomania.


Depression in the menopause.

Depression in the menopause.


The polygraph in a psychiatric setting.

The polygraph in a psychiatric setting.


An episode of acute, self-limiting depersonalization following a first session of hypnosis.


What is a dietetic food?

What is a dietetic food?


Production and acceptance of low-calorie-foods.


Inborn errors of metabolism.

Inborn errors of metabolism.


Evaluation of school feeding programmes in Japn.


Evaluation of school feeding programmes in some European countries.


Indirect injury of the optic nerves and chiasm with closed head injruy. Report of three cases.


Non-mydriatic pupils occurring in human brain death.


St. Joseph Hospital, Albuquerque, and the New Mexico Health Care Corporation.


Calcification of the auricular cartilage and basal ganglia secondary to radiation therapy.


Leadership and the mission of influence.


Nonprofit hospitals and the NLRA exemption.


Inservice education on a psychiatric unit.


Hospital labor relations legislation: an examination and critique of public policy.


The Catholic Church: relevance and mission.


Christian ministry and health service.

Christian ministry and health service.


Interaction of population growth, industrial growth and pollution control.


A new method for measuring average 24-hour nitrogen dioxide concentrations in the atmosphere.


A direct measurement method for dustfall.


An ultrastructural study of the effects of hypophysectomy on the supraoptic nucleus of the rat.


Retrohippocampal, hippocampal and related structures of the forebrain in the reeler mutant mouse.


Relationship of myelin internode elongation and growth in the rat sural nerve.


Rubrobulbar projections in the rabbit. A light and electron microscopic study.


Methadone programs.

Methadone programs.


Narcotic antagonist. Sublingual injection in acute heroin overdose.


CODAC--community organization for drug abuse control.


Alcoholism: diagnosis and treatment. The physician's role.


Damages awarded for failure to diagnose breast cancer.


Effective fixed charge density governing membrane phenomena. V. A reduced expression of permselectivity.


Drug abuse--American dilemma.

Drug abuse--American dilemma.


Headache: recognition and treatment. A brief review for the physician.


The pharmacist and the doctor.

The pharmacist and the doctor.


Neurologic manifestations of Sjogren's syndrome, 1972.


Administration of 5-fluorouracil by hypodermoclysis.


Recent advances in the surgical treatment of arthritis of the hip.


New frontier: electrosleep therapy.

New frontier: electrosleep therapy.


Miscellaneous soft tissue lesions of the extremities.


Soft tissue radiographic technique.

Soft tissue radiographic technique.


Reontgenologic evaluation of disorders of muscle.


Nonparasitic inflammatory diseases of the soft tissues.


Anatomy of the coronary arteries.

Anatomy of the coronary arteries.


Soft tissue changes accompanying vascular diseases of the extremities.


Quantitative studies on salivary blood group substances. II. Normal values.


Preservation of coagulation factors V and VIII during collection and subsequent storage of bank blood in ACD-A and CPD solutions.


A study of African H-deficient A 2  and A 2 B phenotypes.


Limited blood group tests on samples from two coelacanths (Latimeria chalumnae).


Three further antigen-antibody specificities associated with the Kell blood group system.


Quantitative studies on salivary blood group substances. I. Metholology and physiological variables.


Some drugs we would like to have in nutrition and metabolism.


Amylase and protein in parotid saliva after load doses of different dietary carbohydrates.


Small intestine in pellagra.

Small intestine in pellagra.


The vascular effect of monosodium glutamate.


Intestinal absorption using vibration-obtained individual small bowel epithelial cells of the rat: folate absorption.


Transfer ribonucleic acid of vitamin A-deficient rats.


Erythrocyte aminotransferase activities in women using oral contraceptives and the effect of vitamin B 6  supplementation.


Diet and coronary heart disease.

Diet and coronary heart disease.


The equations governing weight change in human beings.


The nutrition of Malaysian aboriginal children.


Nutritional status and intestinal function among rural populations of the West Indies. 3. Barrio Cabreto, Dominican Republic.


Canadian experience with a copper-covered intrauterine contraceptive device. 518 patients were inserted with T-Cu120sq. mm(168), T-Cu200sq.  mm(250), and Lippes Loop (60) for a 20-month comparative study of the devices.  Events of spotting, dysmenorrhea, metrorrhagia, and secondary side effects were less in the T-Cu devices.  The expulsion rate was higher for the T-Cu200sq. mm than T-Cu120sq. mm, but for all other types of termination the T-Cu120sq. mm was highest.  Termination rate for Lippes Loops was 19.66; T-Cu120sq. mm 32.03; and T-Cu200sq. mm, 24.17.  Insertion was easier with T devices.


Amniotic fluid phospholipids and fetal maturity.


Experience with an obstetrical and neonatal intensive care unit.


The suprapubic approach to primary stress urinary incontinence.


Induction of ovulation with cisclomiphene.


The effect of legal abortion on the rate of septic abortion at a large county hospital.


Changing status of tubal sterilization. An evaluation of fourteen years' experience.


Prevention of the postpartum spinal headache.


The pre-ejection period of the fetal heart: detection during labor with Doppler ultrasound.


The pre-ejection period of the fetal heart: response to stress in the term fetal lamb.


Quantitation of the estrogenic effects of mestranol on human endometrium and vaginal mucosa.


The Pereyra procedure in the management of urinary stress incontinence.


The termination of adolescent out-of-wedlock pregnancies and the prospects for their primary prevention.


Oxytocin administration in mid-trimester saline abortions.


A fine structural characterization of the proliferated endocrine cells in atrophic gastric mucosa. This study shows that most of the proliferated endocrine cells in nonintestinalized epithelium in the body of stomachs in patients with pernicious anemia have the fine structure of ECL (enterochromaffin-like) cells, the principal endocrine cell in the body of normal stomachs, and notes an absence of G (gastrin) cells, the principal endocrine cell in the normal pylorus. Since gastrin has been identified in many of these proliferated cells by immunofluorescence, these findings question the position that gastrin synthesis in the stomach is only associated with G cells.


Animal model of human disease. Myocardial failure, muscular dystrophy.


Mitochondrial proliferation within the nephron. I. Comparison of mitochondrial hyperplasia of tubular regeneration with compensatory hypertrophy. MITOCHONDRIAL PROLIFERATION IN THE RENAL PROXIMAL TUBULAR EPITHELIUM IN RESPONSE TO TISSUE LOSS HAS BEEN QUANTITATED BY TWO DIVERSE MODELS: acute tubular necrosis induced by mercuric chloride and unilateral nephrectomy. The increased work demand on the remaining tubular mass in both models has probably stimulated both cell hyperplasia and hypertrophy. In both instances, cell hyperplasia preceeds hypertrophy. During the cellular hypertrophy, mitochondria first proliferate in number and then increase in size; presumably to satisfy the greater need for energy metabolism necessary during increased active transtubular solute transport.


The fine structure of granulosa cell nexuses in rat ovarian follicles.


The persistence of a circadian rhythm in histamine response in guinea pigs maintained under continuous illumination.


Differential morphology of mouse spleen cells stimulated in vitro by endotoxin, phytohemagglutinin, pokeweed mitogen and staphylococcal enterotoxin B. The in vitro mitogenic effects of endotoxin (LPS), phytohemagglutinin (PHA), pokeweed mitogen (PWM) and staphylococcal enterotoxin B (SEB) on mouse spleen cells were studied by light and electron microscopy. By light microscopy, LPS was found to "transform" a culture largely composed of small lymphocytes into "large lymphocytes" which did not synthesize DNA and into blast cells which did synthesize DNA. The blast cells were morphologically similar to those transformed by PHA, PWM and SEB. By electron microscopy, a large percentage of the endotoxin-transformed cells developed extensive dilated rough ER. Their appearance was similar to that reported by others for cells stimulated by PWM, but in our hands the development of rough ER was more conspicuous in LPS-stimulated cells. In contrast, PHA and SEB produced few blast cells which contained significant rough ER. The morphologic observations are consistent with the hypothesis that the mitogenic effect of endotoxin is on bone-marrow-derived lymphocytes. This effect may relate to the known adjuvant effect of endotoxin in vivo.


Explants of rat adrenal medulla. A light and electron microscopic study.


Studies on the peripheral blood cell parameters and morphology of the red paradise fish, Macropodus opercularis. Effect of food deprivation on erythropoiesis.


Toxicity of long-term exposure to oxides of sulfur.


Experimental human exposure to high concentrations of carbon monoxide.


Human perception of humidity under four controlled conditions.


Pulmonary function in shipyard welders: an epidemiologic study.


Genetic disorders in isolated populations.


Beryllium-induced ultrastructural changes in intact and regenerating liver.


The role of estrogen in the regulation of erythropoietin production.


The modulation of pregesterone concentration in the myometrium of the pregnant rat by changes in cytoplasmic "receptor" protein activity.


Studies on growth hormone secretion. V. Influence of plasma free fatty acid levels.


Immunologic and biologic behavior of hCG and bovine LH subunit hybrids.


Pineal control of a seasonal reproductive rhythm in male golden hamsters exposed to natural daylight and temperature.


Growth hormone covalently bound to Sepharose. II. Study of the biological activity of a growth hormone-Sepharose complex in adipose tissue and diaphragm muscle.


Alterations of radioimmunoassayable growth hormone and prolactin during hypothroidism.


The role of gonadotropins in the development of cyclicity in the rat.


Suppression of anterior pituitary in rats bearing a transplantable growth hormone and prolactin-secreting tumor (MtT-W10).


Testicular endocrine function in Hereford bulls exposed to high ambient temperature.


Characteristics of gonadotropin receptors of porcine granulosa cells during follicle maturation.


The effect of calcium concentration on calcium uptake by bone cells treated with thyrocalcitonin (TCT) hormone.


Effects of Ca ++  and Mg ++  on secretion and synthesis of growth hormone and prolactin by clonal strains of pituitary cell in culture.


Inhibition of bone resorption by colchicine in organ culture.


Effect of insulin on glycogen synthesis in fetal rat liver in organ culture.


Aromatization in the central nervous system of rabbits: effects of castration and hormone treatment.


Hormonal regulation of spermidine formation during spermatogenesis in the rat.


Neuroendocrine basis of ovulation in hamsters treated with prostaglandin F-2 .


Failure of 6-hydroxydopamine to abolish the circadian rhythm of serum corticosterone.


The appearance of an endometrial 20 -hydroxysteroid dehydrogenase towards the end of pregnancy in the rat.


A delayed antagonistic effect of progesterone on estradiol induced increases in uterine glucose-6-phosphate dehydrogenase.


Cellular and subcellular localization of radioactivity in the rat pituitary after injection of 1,2-3H-testosterone using dry-autoradiography.


Libel and medical staff discipline.

Libel and medical staff discipline.


A small service, a big aid.

A small service, a big aid.


Innovation: key to better health.

Innovation: key to better health.


New training program for hospitals.

New training program for hospitals.


The nurse epidemiologist.

The nurse epidemiologist.


Plan for function, not for space.

Plan for function, not for space.


Small hospital CCU made possible by leasing.


Fire protection systems tested.

Fire protection systems tested.


Convenience foods decision: no.

Convenience foods decision: no.


Small hospital switches to five meals a day.


JCAH standards generate goals.

JCAH standards generate goals.


TV chapel reaches more patients.

TV chapel reaches more patients.


Wages based on merit, not tenure.

Wages based on merit, not tenure.


Planning a chapel and its services.

Planning a chapel and its services.


Hydrolysis of D-glucono-delta-lactone. I. General acid-base catalysis, solvent deuterium isotope effects, and transition state characterization.


Oxidation of iron (II) porphyrins by alkyl halides.


Diffusion studies on phosphatidylcholine vesicles.


A model conformational study of nucleic acid phosphate ester bonds. The torsional potential of dimethyl phosphate monoanion.


Cyclic peptides. V. 1 H and 13 C nuclear magnetic resonance determination of the preferred beta conformation for proline-containing cyclic hexapeptides.


A novel compound with a planar Fe-S-S-Fe bridge and its possible relation to ferredoxins.


Biosynthesis of menaquinones. Dissymmetry in the naphthalenic intermediate.


Use of argentation column chromatography in the identification of fish oil fatty acids by GLC: application to cod liver oil.


The axostyle of Saccinobaculus. I. Structure of the organism and its microtubule bundle. The axostyle of the flagellate Saccinobaculus is a motile ribbon composed of microtubules, cross-bridged to form interconnected rows. We find a centriole-related row of dark-staining tubules near the nucleus at the anterior end of the axostyle. Other tubule rows bind parallel to this primary row, acquire ordered relationships, and become the tubules of the axostyle proper. The number of tubule rows is constant in Saccinobaculus lata from the region near the nucleus to within a few micrometers of the posterior tip of the cell. In Saccinobaculus ambloaxostylus a few tubule rows are added to the axostyle posterior to the nucleus, giving this axostyle a leaf spring construction. The tubules of S. lata are held in rows by links with a 140 A periodicity along the tubule axis; bridges between rows of tubules are also seen but are not apparently periodic. Each tubule in S. ambloaxostylus shows an axial periodicity of 150 A due to pairs of arms, one of which is always part of the intrarow link. Interrow bridges in this species run either from tubule to tubule or from tubule to the free arm, but as in S. lata they do not display an obvious axial periodicity. An average unit cell is presented for the axostyle of each species, and the relation of the intertubule links to the microtubule substructure is discussed.


Microtubule biogenesis and cell shape in Ochromonas. I. The distribution of cytoplasmic and mitotic microtubules. In the first of two companion papers which attempt to correlate microtubules and their nucleating sites with developmental and cell division patterns in the unicellular flagellate, Ochromonas, the distribution of cytoplasmic and mitotic microtubules and various kinetosome-related fibers are detailed. Of the five kinetosome-related fibers, which have been found in Ochromonas, two, the kineto-beak fibers and the rhizoplast fibers are utilized as attachment sites for distinct groups of microtubules. The set of microtubules attached to the kineto-beak fibers apparently shape the anterior beak region of the cell whereas the rhizoplast microtubules appear to extend into and shape the tail in vegetative cells. In mitotic cells a rhizoplast is found at each spindle pole apparently serving as foci for the spindle microtubules. These findings are discussed in relation to the less well defined attachment sites for vegetative and mitotic microtubules in other kinds of cells. It is noted that the effects of depolymerizing microtubules in vivo might be easily quantitated in whole populations since no external wall or pellicle contributes to the maintenance or the biogenesis of the characteristic cell form of Ochromonas.


Microtubule biogenesis and cell shape in Ochromonas. II. The role of nucleating sites in shape development. The proposal made in the preceding paper that the species-specific shape of Ochromonas is mediated by cytoplasmic microtubules which are related to two nucleating sites has been experimentally verified. Exposure of cells to colchicine or hydrostatic pressure causes microtubule disassembly and a correlative loss of cell shape in a posterior to anterior direction. Upon removal of colchicine or release of pressure, cell shape regenerates and microtubules reappear, first in association with the kineto-beak site concomitant with regeneration of the anterior asymmetry, and later at the rhizoplast site concomitant with formation of the posterior tail. It is concluded that two separate sets of cytoplasmic tubules function in formation and maintenance of specific portions of the total cell shape. On the basis of the following observations, we further suggest that the beak and rhizoplast sites could exert control over the position and timing of the appearance, the orientation, and the pattern of microtubule distribution in Ochromonas. (a) the two sites are accurately positioned in the cell relative to other cell organelles; (b) in regenerating cells microtubules reform first at these sites and appear to elongate to the cell posterior; (c) microtubules initially reappear in the orientation characteristic of the fully differentiated cell; (d) the two sets of tubules are polymerized at different times, in the same sequence, during reassembly or resynthesis of the microtubular system. Experiments using cycloheximide, after a treatment with colchicine, have demonstrated that Ochromonas cannot reassume its normal shape without new protein synthesis. This suggests that microtubule protein once exposed to colchicine cannot be reassembled into microtubules. Pressure-treated cells, on the other hand, reassemble tubules and regenerate the normal shape in the presence or absence of cycloheximide. The use of these two agents in analyzing nucleating site function and the independent processes of synthesis and assembly of microtubules is discussed.


The persistence of hemopoietic stem cells in vitro. Cells capable of forming colonies in spleens of irradiated mice (CFU) are lost temporarily when bone marrow cells from rats or mice are maintained in culture. Rat marrow CFU go through a minimum at about 3 days after which there is a slow increase in the number of CFU in culture, reaching a maximum at 9 days. Mouse marrow CFU reach a minimum at 3 days and a maximum at 7 days. Some rat marrow CFU persist in culture for as long as 28 days.


Synthesis of Paramecium surface proteins. I. Puromycin insensitive amino acid incorporation. The synthesis of a surface protein has been studied in Paramecium through double-labeling experiments using [(14)C]- and [(3)H]leucine-labeled bacteria as the source of radioactive amino acid. Over a 4-5 h incubation period, the turnover rate was found to be higher than that of overall cell protein. In addition, the initial label is apparently utilized during the chase period, being incorporated into protein via a puromycin insensitive pathway.


The development of microbodies and peroxisomal enzymes in greening bean leaves. The ontogeny of leaf microbodies (peroxisomes) has been followed by (a) fixing primary bean leaves at various stages of greening and examining them ultrastructurally, and (b) homogenizing leaves at the same stages and assaying them for three peroxisomal enzymes. A study employing light-grown seedlings showed that when the leaves are still below ground and achlorophyllous, microbodies are present as small organelles (e.g., 0.3 microm in diameter) associated with endoplasmic reticulum, and that after the leaves have turned green and expanded fully, the microbodies occur as much larger organelles (e.g., 1.5 microm in diameter) associated with chloroplasts. Specific activities of the peroxisomal enzymes increase 3- to 10-fold during this period. A second study showed that when etiolated seedlings are transferred to light, the microbodies do not appear to undergo any immediate morphological change, but that by 72 h they have attained approximately the size and enzymatic activity possessed by microbodies in the mature primary leaves of light-grown plants. It is concluded from the ultrastructural observations that leaf microbodies form as small particles and gradually develop into larger ones through contributions from smooth portions of endoplasmic reticulum. In certain aspects, the development of peroxisomes appears analogous to that of chloroplasts. The possibility is examined that microbodies in green leaves may be relatively long-lived organelles.


Nonuniform rates of turnover of myofibrillar proteins in rat diaphragm.


Isoproterenol-induced phase shifts in circadian rhythm of mitosis in murine corneal epithelium.


RNA synthesis in chromosome connectives.


The effect of phagocytosis and spreading on macrophage surface receptors for concanavalin A.


GLC determination of strychnine and brucine in pharmaceutical preparations.


Absorbance-pH relationship in the steroid-tetrazolium reaction.


Characterization of crystalline calcium pantothenate by physicochemical assay methods.


Analog computer program for simulating variable dosing regimens.


Variation on the USP-NF rotating-basket dissolution apparatus and a new device for dissolution rate studies of solid dosage forms.


Design and use of a laboratory extruder for pharmaceutical granulations.


Chemical constituents of gentianaceae. IV. New xanthones of Canscora decussata.


Antitumor agents from Alnus oregona (Betulaceae).


Viscosity changes in salicylic acid-cetrimide system by surfactants.


In vitro and in vivo hydrolysis of 4-benzoylphenyl N-methylcarbamate.


Mass fragmentographic detection of normorphine in urine of man after codeine intake.


Synthesis of site-directed chelating agents. I. Pteridine carboxaldehyde thiosemicarbazones.


Isoxazoles. I. Protonation of isoxazole derivatives in aqueous sulfuric acid.


Isoxazoles. II. Kinetics and mechanism of degradation of sulfisoxazole in moderately concentrated acids.


New compounds: N,N-dimethyl-(3-1-alkylipiperidyl))carbamates, potential cholinesterase inhibitors.


Effect of an inhibitor of glucuronide formation on elimination kinetics of diphenylhydantoin in rats.


Further comments on the existence of spherical micelles.