Dermal gangrene. An unpredictable complication of coumarin therapy.


Reconstruction of the pulmonary valve and outflow tract. A report of 25 cases.


Hemodynamic confirmation of obstruction to left ventricular inflow by a caged-ball prosthetic mitral valve. Case report.


Late causes of death after mitral valve replacement. Analysis of 36 cases.


Successful repair of pericardial patch stenosis after Mustard procedure. Diagnostic and therapeutic considerations in two patients.


Radionuclide angiography in the diagnosis of aortocaval fistula. Report of two cases.


Effect of dextran on patency of pericardial tubular graft of the superior vena cava in the dog.


The natural history of pacemaker wires.

The natural history of pacemaker wires.


Morphology of blood-surface interaction on intra-aortic balloons. An analysis of clinical and experimental specimens by scanning electron microscopy.


Tetralogy of Fallot with aortic origin of the right pulmonary artery. Surgical implications.


Lung cancer--future projection.

Lung cancer--future projection.


Dibutylbarbituric acid as an impurity in butobarbital tablets.


Developmental assessment: a test for gross motor and reflex development.


Electrode placement and muscle action potentials amplitudes.


Total hip arthroplasty and postoperative rehabilitation.


CNS regeneration research.

CNS regeneration research.


The expanding role of the physical therapist on the amputee rehabilitation team.


Postoperative program and recovery of a patient with multiple sclerosis following repair of a hip fracture.


A universal temporary ankle-foot orthosis.


Motorized stretching of the soleus and gastrocnemius muscles.


Student produced movie: a valuable project in learning kinesiology.


Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man. A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.


Retzius cells: neuroeffectors controlling mucus release by the leech. Mucus release from the skin of leeches is under the control of the pair of large Retzius cells in each segmental ganglion. The rate of mucus release increases with the impulse activity of Retzius cells and with the concentration of their putative neurotransmitter, 5-hydroxytryptamine, to which the skin is exposed.


Familial hypophosphatemic rickets: defective transport of inorganic phosphate by intestinal mucosa. Uptake of inorganic phosphate is impared in intestinal mucosa from hemizygous males and heterozygous females with X-linked familial hypophosphatemic rickets. Considerable intrafamilial and interfamilial variation in uptake of inorganic phosphate is observed in affected patients. Uptake by normal mucosa is concentrative and energy-dependent, and is mediated by at least two systems with widely different affinities. These results lend direct support to the thesis that the primary metabolic disturbance in this disease results from impaired transport of inorganic phosphate in kidney and gut.


Cholesterol: vitamin C controls its transformation to bile acids. Cholesterol accumulates in the blood serum and in the liver of guinea pigs with chronic latent vitamin C deficiency. The reason for this is the decreased rate of transformation of cholesterol to bile acids in the liver of animals deficient in vitamin C. A significant direct correlation exists between the vitamin C concentration in the liver and the rate of cholesterol transformation to bile acids.


Development of grooming in mice with amputated forelimbs. Face grooming sequences that involve coordination of the shoulders, tongue, and eyes develop remarkably normally in inbred mice with one or both forelimbs amputated from birth. This indicates endogenous control with a strong genetic component. Evidence for the maturational expression of "sensory expectations" was also obtained.


Trace element concentrations in aerosols from the San Francisco Bay Area.


Modelling urban air pollution.

Modelling urban air pollution.


Optimal distribution of air pollution sources.


Structure and properties of hemocyanins. 8. Microheterogeneity of  -hemocyanin of Helix pomatia.


The composition of sea urchin sperm and embryo histones.


Characteristics of  -crystallin related to fiber cell development in calf eye lenses.


Nuclear basic protein acetylation during early sea urchin development.


Amino and carboxy terminal sequence of  -crystallin, from haddock lens.


The structure of human thyroglobulin: sedimentation equilibrium in 6M guanidine hydrochloride.


Rapid preequilibrium determination of molecular weights in the ultracentrifuge.


2 -acute phase globulin in rat serum. Purification, determination and interaction with trypsin.


Purification of a human urinary glycoprotein with gastric antisecretory activity.


An improved technique for the near infrared study of water binding by proteins. Illustration with gelatin.


Release of an N-terminal peptide from human plasminogen during activation with urokinase.


Solvation of  -lactoglobulin and chymotrypsinogen A in aqueous urea solutions.


A new case of hemoglobin Genova   2    2  28(B10) Leu leads to Pro. Further studies on the mechanism of instability and defective synthesis.


Clofibrate-induced antidiuresis.

Clofibrate-induced antidiuresis. Normal subjects and patients with antidiuretic hormone (ADH) deficiency were studied to determine the mechanism of the antidiuretic action of clofibrate. Before clofibrate treatment, the patients' ability to concentrate urine with a standardized dehydration procedure correlated with the amount of ADH which was excreted. During clofibrate administration all six patients with ADH deficiency developed an antidiuresis which was like that of ADH, since there was no change in sodium, potassium, total solute, or creatinine excretion. There was a correlation between the patients' ability to concentrate urine during dehydration and the subsequent response to clofibrate, and the excretion of ADH during dehydration correlated with the excretion of ADH on clofibrate therapy. Clofibrate-induced antidiuresis in these patients was partially overcome by ethanol and by water loading. Clofibrate interfered with the ability of patients and subjects to excrete a water load and prevented the water load from inhibiting ADH excretion in the normal subjects. These studies suggested that clofibrate was acting through endogenous ADH and this thesis was supported by the failure of clofibrate to produce an antidiuresis when injected into rats with total ADH deficiency (Brattleboro strain) although an antidiuresis was produced in water-loaded normal rats. When the drug was injected into Brattleboro rats with exogenous ADH, clofibrate either did not alter or it inhibited the action of the ADH. The data demonstrate that clofibrate has a significant ADH-like action. This action appears to be mediated through the release of endogenous ADH.


The stimulation of 1,25-dihydroxycholecalciferol metabolism in vitamin D-deficient rats by 1,25-dihydroxycholecalciferol treatment. Daily oral administration of 1,25-dihydroxycholecalciferol to vitamin D-deficient rats increases the rate of disappearance of [(3)H]1,25-dihydroxycholecalciferol and increases the rate of appearance of metabolites both less polar and more polar than 1,25-dihydroxycholecalciferol in the intestine, bone, liver, kidney, plasma, and muscle. Since 1,25-dihydroxycholecalciferol is believed to be the metabolically active form of vitamin D in the stimulation of intestinal calcium transport and bone calcium mobilization, these results provide an explanation for the fact that daily oral administration of 1,25-dihydroxycholecalciferol is relatively ineffective in the maintenance of serum calcium and in the calcification of bone in rats.


Hyperoxia: a stereologic ultrastructural examination of its influence on cytoplasmic components of the pulmonary granular pneumocyte. We used the technique of lineal analysis to study the influence of 48 h of hyperoxia on cytoplasmic organelles of pulmonary granular pneumocytes with particular reference to their lamellar bodies. We undertook this study because lamellar bodies are considered to be storage granules for pulmonary surfactant and because we had found that hyperoxia decreased [(14)C]leucine incorporation into protein of a surface-active lung fraction. We found that for lamellar bodies the percent cytoplasmic volume was 12.8+/-1.5 (mean+/-SEM) and 8.4+/-2.2, the organelle area (mum(2)) per organelle was 0.98+/-0.13 and 0.62+/-0.10 and the organelle volume (mum(2)) was 0.35+/-0.04 and 0.18+/-0.01, for air- and oxygen-exposed rats, respectively, (P=<0.05). The surface density of the lamellar body membrane was 7.05+/-0.47 and 9.36+/-0.96 (P=<0.05) for air- and oxygen-exposed rats. There were no differences in lamellar body number per cytoplasmic area or per pneumocyte between air- and oxygen-exposed rats. There were no statistical differences in these parameters between mitochondria of air- or oxygen-exposed rats. The surface density of the rough endoplasmic reticulum was the same in both groups. This study indicates that granular pneumocytes of rats exposed to hyperoxia have the same number of lamellar bodies as control rats but the lamellar bodies are smaller. This findings in consistent with the hypothesis that the hyperoxia-induced decrease in protein synthesis by lung represents at least in part a decreased synthesis of the secretory lipoprotein-pulmonary surfactant.


Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. The effectiveness of various antibiotics commonly recommended for the prophylaxis of bacterial endocarditis has been evaluated in experimental streptococcal endocarditis in rabbits. High doses of penicillin G did not prevent the development of this infection. The only consistently successful prophylactic regimens using penicillin alone were those which provided for both an early high serum level and more than 9 h of effective antimicrobial action. Vancomycin was the only other drug which proved uniformly successful when given alone, even though the duration of its antimicrobial action in the blood was only 3 h. However, combined therapy using penicillin G or ampicillin with streptomycin was always effective in prophylaxis. Treatment with single injections of ampicillin, cephaloridine, cephalexin, clindamycin, cotrimoxazole, rifampicin, streptomycin, erythromycin, and tetracycline failed to prevent infection. The findings provide information on the effect of antimicrobials in vivo and may be applicable to the chemoprophylaxis of infective endocarditis in clinical practice.


Studies on mechanisms of cerebral edema in diabetic comas. Effects of hyperglycemia and rapid lowering of plasma glucose in normal rabbits. To investigate the pathophysiology of cerebral edema occurring during treatment of diabetic coma, the effects of hyperglycemia and rapid lowering of plasma glucose were evaluated in normal rabbits. During 2 h of hyperglycemia (plasma glucose=61 mM), both brain (cerebral cortex) and muscle initially lost about 10% of water content. After 4 h of hyperglycemia, skeletal muscle water content remained low but that of brain was normal. Brain osmolality (Osm) (343 mosmol/kg H(2)O) was similar to that of cerebrospinal fluid (CSF) (340 mosmol/kg), but increases in the concentration of Na+, K+, Cl-, glucose, sorbitol, lactate, urea, myoinositol, and amino acids accounted for only about half of this increase. The unidentified solute was designated "idiogenic osmoles". When plasma glucose was rapidly lowered to normal with insulin, there was gross brain edema, increases in brain content of water, Na+, K+, Cl- and idiogenic osmoles, and a significant osmotic gradient from brain (326 mosmol/kg H(2)O) to plasma (287 mosmol/kg). By similarly lowering plasma glucose with peritoneal dialysis, increases in brain Na+, K+, Cl-, and water were significantly less, idiogenic osmoles were not present, and brain and plasma Osm were not different. It is concluded that during sustained hyperglycemia, the cerebral cortex adapts to extracellular hyperosmolality primarily by accumulation of idiogenic osmoles rather than loss of water or gain in solute. When plasma glucose is rapidly lowered with insulin, an osmotic gradient develops from brain to plasma. Despite the brain to plasma osmotic gradient, there is no net movement of water into brain until plasma glucose has fallen to at least 14 mM, at which time cerebral edema occurs.


Glucose utilization and production by the dog kidney in vivo in metabolic acidosis and alkalosis. Using D-[1-(14)C]glucose as a tracer, renal glucose utilization and production was measured in chronic metabolic acidosis and alkalosis in dog kidney in vivo. In six experiments in acidosis, mean total renal glucose production was 4.447+/-1.655 SE mumol/min and glucose utilization was 4.187+/-0.576 SE mumol/min. In five alkalotic experiments it was found that mean total glucose production was 12.227+/-2.026 SE mumol/min and glucose utilization was 18.186+/-2.054 SE mumol/min. Renal glucose utilization and production are therefore significantly higher in alkalosis than in acidosis in vivo. Since glucose production is maximal under conditions when glutamine extraction is minimal (i.e. alkalosis), it is apparent that in alkalosis glutamine is not a major precursor of glucose.


Reduction of experimental myocardial infarct size by corticosteroid administration. The influence of the administration of pharmacologic doses of hydrocortisone on the extent and severity of acute myocardial ischemic injury and on subsequent necrosis after acute coronary occlusion was investigated in 28 dogs. In order to study acute myocardial injury, repeated epicardial electrocardiograms were recorded from 10 to 15 sites on the anterior surface of the left ventricle. Average ST segment elevation (ST) and the number of sites in which ST segment elevation exceeded 2 mV (NST), indices of the magnitude and extent of myocardial injury, respectively, were analyzed at 30 and 60 min after coronary occlusion. In the control group ST and NST did not change significantly in this time interval while in the treated group, which received 50 mg/kg hydrocortisone just after the 30 min recording, ST fell from 3.5+/-0.8 to 1.1+/-0.4 mV (P<0.01) and NST was reduced from 6.7+/-1.1 to 1.4+/-0.8 (P<0.01). In order to study the influence of hydrocortisone on necrosis, epicardial ST segment elevation 15 min after coronary occlusion was compared to myocardial creatine phosphokinase activity (CPK) and histologic appearance 24 h later in each site. In a control group (14 dogs) a relationship was established between ST segment elevation at 15 min (in millivolts) and CPK activity (in international units per milligram of protein) 24 h later: log CPK = -0.0611ST + 1.26 (N = 102 specimens, r = -0.79). In the treated groups, hydrocortisone (50 mg/kg i.v.) was given either at 30 min after occlusion (seven dogs) or at 6 h after occlusion (six dogs). Both groups received supplementary doses of hydrocortisone (25 mg/kg) 12 h after occlusion. The two treated groups exhibited less CPK depression than that expected from ST segment elevation at each site, with slopes of the regression lines which were significantly less steep: log CPK = -0.0288ST + 1.26 (N = 48, r = -0.71) and log CPK = -0.0321ST + 1.31 (N = 48, r = -0.76) in the (1/2) h and 6 h groups, respectively. Histologically, sites with ST segment elevations of less than 2 mV at 15 min after occlusion exhibited normal appearance 24 h later. Sites with ST segment elevations (> 2 mV) in the control group showed histologic changes compatible with early myocardial infarction in 96% of specimens, while this occurred only in 61% and 63% of specimens, respectively, in the treated groups, showing that over one third of the sites were protected from undergoing necrosis due to the intervening hydrocortisone treatment. Thus pharmacological doses of hydrocortisone prevent myocardial cells from progressing to ischemic necrosis even when administration is initiated 6 h after coronary occlusion.


Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport. Transport of NaCl and water was examined in the rabbit medullary thick ascending limb of Henle (ALH) by perfusing isolated segments of these nephrons in vitro. Osmotic water permeability was evaluated by perfusing tubules against imposed osmotic gradients. In these experiments the net transport of fluid remained at zero when segments of thick ALH were perfused with isotonic ultrafiltrate in a bath of rabbit serum in which the serum osmolality was increased by the addition of either 239+/-8 mosmol/liter of raffinose or 232+/-17 mosmol of NaCl indicating that the thick ascending limb of Henle is impermeant to osmotic flow of water. When these tubules were perfused at slow rates with isosmolal ultrafiltrate of same rabbit serum as used for the bath, the effluent osmolality was consistently lowered to concentrations less than the perfusate and the bath. That this decrease in collected fluid osmolality represented salt transport was demonstrated in a separate set of experiments in which it was shown that the sodium and chloride concentrations decreased to 0.79+/-0.02 and 0.77+/-0.02 respectively when compared with the perfusion fluid concentrations. In each instance the simultaneously determined transtubular potential difference (PD) revealed the lumen to be positive with the magnitude dependent on the perfusion rate. At flow rates above 2 nl.min(-1), the mean transtubular PD was stable and equal to 6.70+/-0.34 mv. At stop-flow conditions this PD became more positive. Ouabain and cooling reversibly decreased the magnitude of this PD. The transtubular PD remained positive, 3.3+/-0.2 mV, when complete substitution of Na by choline was carried out in both the perfusion fluid and the bathing media. These results are interpreted to indicate that the active transport process is primarily an electrogenic chloride mechanism. The isotopic permeability coefficient for Na was 6.27+/-0.38 x 10(-5) cm.s(-1) indicating that the thick ALH is approximately as permeable to Na as the proximal convoluted tubule. The chloride permeability coefficient for the thick ALH was 1.06+/-0.12 x 10(-5) cm.s(-1) which is significantly less than the chloride permeability of the proximal tubule. These data demonstrate that the medullary thick ascending limb of Henle is water impermeable while having the capacity for active outward solute transport as a consequence of an electrogenic chloride pump. The combination of these characteristics allows this segment to generate a dilute tubular fluid and participate as the principal energy source for the overall operation of the countercurrent multiplication system.


Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. New methods are described by which the buffer content and the rate and pattern of net gastric acid secretion in human subjects fed normal meals can be measured by use of sodium bicarbonate infusion to control intragastric pH. With these techniques, it was shown that the rate of acid secretion in response to a steak meal in seven duodenal ulcer patients was twice the rate achieved in six control subjects and that the amount of acid secreted after eating exceeded the peak histamine response in the ulcer patients but not in the controls. Meal-stimulated acid secretion, expressed as a function of the peak histamine response, was roughly correlated with the serum gastrin concentration (r = 0.45), but it was concluded that other factors must also contribute to the higher than normal secretory responses to a meal found in duodenal ulcer patients. Measurement of buffer content of the stomach revealed that the duodenal ulcer patients emptied the meal buffer at a much more rapid rate than the normal subjects. By 2 h after eating, the ulcer subjects had less than half as much buffer in their stomachs as the controls. The combination of acid hypersecretion and rapid buffer emptying leads to abnormally high gastric acidity after a meal in duodenal ulcer patients. These results suggest that, in addition to a large parietal cell mass, parietal cell responsiveness to a meal and the rate of buffer emptying may be important in the pathogenesis of duodenal ulcer.


Maturation of the human complement system. I. Onset time and sites of fetal C1q, C4, C3, and C5 synthesis. The onset times and sites of human C1q, C4, C3, and C5 synthesis were determined by culturing tissues from 23 fetuses, 8-25 wk old, in the presence of [(14)C]lysine and isoleucine. In parallel, IgG and IgM production was followed. Liver, spleen, placenta, peritoneal and bone marrow cells, thymus, and colon were cultured for 48 h and the concentrated media studied by immunoelectrophoresis and subsequent autoradiography using adult human serum as carrier and specific antisera. The quantitative synthesis was approximated by scoring the intensity of the labeled precipitin lines using uniform conditions. C5 production was detected earliest at 8 wk gestation and by 11 wk and thereafter, C3, C4, and C5 synthesis was uniformly present in multiple tissues. C1q synthesis, however, was limited almost exclusively to the spleen, began at 14 wk, and was not uniformly present. In contrast IgG and IgM production did not occur in three fetuses synthesizing complement and while detected as early as 11 wk. was inconstant, occurred predominantly in the spleen, and was quantitatively much less compared to C3, C4, and C5. These findings suggest that developmentally the complement system is a more primative biological defense mechanism than antibody.


Synthesis of globin chains in sickle  -thalassemia. In five patients with sickle beta-thalassemia there was balanced alpha- and beta-globin synthesis in the bone marrow and decreased total beta-chain synthesis relative to that of alpha-chain in the peripheral blood. These findings are similar to those in patients with simple beta-thalassemia trait. Despite a range of hemoglobin concentrations from 6.8 to 12.5 g/100 ml in the patients with sickle thalassemia, there was no evidence of a significant excess of alpha-chains in the red cells of the bone marrow which could contribute to the hemolysis and anemia. In patients heterozygous for beta-thalassemia the capacity to synthesize beta-chain decreases more rapidly than that for alpha-chain. In nonthalassemic subjects the rates of beta- and alpha-chain synthesis decrease equally as the red cell matures. The beta(S)- and beta(A)-chains serve as convenient markers for globin synthesis due to the nonthalassemic and thalassemic alleles in patients with sickle beta-thalassemia. The unbalanced globin synthesis in the peripheral blood of these patients is explained by the decrease in relative synthesis of beta(S)-chain, in comparison with that of alpha-chain. This instability is not present in sickle cell trait. The beta(A)-chain synthesis was only unstable in the two patients who had the most marked anemia. The major mechanism for achieving balanced globin production in the bone marrow in the presence of one thalassemic gene appears to be increased synthesis of beta-chain due to the nonthalassemic allele. In addition, there may be a decrease of total alpha-chain synthesis in some patients.


The effect of keto-analogues of essential amino acids in severe chronic uremia. Alpha keto-analogues of valine, leucine, isoleucine, methionine, phenylalanine, and (in one instance) tryptophan and histidine, along with the remaining essential amino acids, were administered orally to 10 patients with severe chronic uremia fed a diet low in protein but adequate in calories. Ketoacid dosage varied from 6 to 14 g daily, as sodium or calcium salts. Net nitrogen intake, calculated as intake minus urinary protein nitrogen, averaged 1.8 g/day. The urea space was either estimated or measured with [(14)C]urea and daily changes in the body urea pool were calculated. Urea appearance was measured as the sum of urea excretion and the change in urea pool. If these ketoacids were converted to amino acids and utilized for protein synthesis, a fall in urea nitrogen appearance should occur. In five subjects, ketoacids were given for 15-18 days and then withdrawn. Urea nitrogen appearance increased 1.55 g/day on withdrawing ketoacids, and corrected nitrogen balance decreased by 1.73 g/day. In two other subjects ketoacid administration was followed, on two occasions each, by a period of administration of nine essential amino acids. In three of these four instances, urea appearance rose significantly with amino acids. In four patients studied at high blood urea levels, ketoacid treatment was relatively ineffective; two of these patients responded more favorably when studied again after peritoneal dialysis. One of these improved enough clinically to be managed as an out-patient for short intervals, despite virtual anuria. No accumulation of ketoacids in plasma or urine could be detected, and no toxicity was identified.


Diurnal patterns of triglycerides, free fatty acids, blood sugar, and insulin during carbohydrate-induction in man and their modification by nocturnal suppression of lipolysis. Previous studies have shown that carbohydrate induction of hypertriglyceridemia in normal subjects occurs at night and appears to be related to a rise of free fatty acids after diurnal feeding of high-carbohydrate formula diet. The present investigation was undertaken to observe the effect on 24-h triglyceride, free fatty acid, blood sugar, and plasma insulin profiles of inhibition of nocturnal lipolysis by glucose or nicotinic acid in normal subjects and in patients with type IV hyperlipoproteinemia. In 10 normal subjects and 10 patients with primary type IV hyperlipoproteinemia, plasma triglyceride, free fatty acid, blood sugar, and insulin levels were followed in short intervals for 24 h while a 2,400 cal, 80% carbohydrate, fat-free formula diet was given in six equal portions during the day (control experiments). This procedure was repeated in the same subjects, 10 of whom (5 normal subjects and 5 patients) received additional feedings of glucose between 2000 and 0600 h while the other 10 persons (5 normal subjects and 5 patients) were given nicotinic acid by intravenous infusion during the same time interval. Both procedures resulted in maintained lowering of free fatty acid levels over 24 h. Mitigation of carbohydrate-induced hypertriglyceridemia appeared to result from the additional glucose in normals and in patients. Nicotinic acid abolished the nocturnal rise of plasma triglyceride levels which in the control studies of normal subjects had resulted in approximate doubling of triglyceride levels in 24 h. The effectiveness of nicotinic acid in inhibiting nocturnal lipolysis and preventing carbohydrate-induction of hypertriglyceridemia might have consequences for management of endogenous hypertriglyceridemia.


Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man. [24-(14)C]Dehydrocholic acid (triketo-5-beta-cholanoic acid) was synthesized from [24-(14)C]cholic acid, mixed with 200 mg of carrier, and administered intravenously to two patients with indwelling T tubes designed to permit bile sampling without interruption of the enterohepatic circulation. More than 80% of infused radioactivity was excreted rapidly in bile as glycine- and taurine-conjugated bile acids. Radioactive products were identified, after deconjugation, as partially or completely reduced derivatives of dehydrocholic acid. By mass spectrometry, as well as chromatography, the major metabolite (about 70%) was a dihydroxy monoketo bile acid (3alpha,7alpha-dihydroxy-12-keto-5beta-cholanoic acid); a second metabolite (about 20%) was a monohydroxy diketo acid (3alpha-hydroxy-7,12-di-keto-5beta-cholanoic acid); and about 10% of radioactivity was present as cholic acid. Reduction appeared to have been sequential (3 position, then 7 position, and then 12 position) and stereospecific (only alpha epimers were recovered). Bile flow, expressed as the ratio of bile flow to bile acid excretion, was increased after dehydrocholic acid administration. It was speculated that the hydroxy keto metabolites are hydrocholeretics. The proportion of cholesterol to lecithin and bile acids did not change significantly after dehydrocholic acid administration. In vitro studies showed that the hydroxy keto metabolites dispersed lecithin poorly compared to cholate; however, mixtures of cholate and either metabolite had dispersant properties similar to those of cholate alone, provided the ratio of metabolite to cholate remained below a value characteristic for each metabolite. These experiments disclose a new metabolic pathway in man, provide further insight into the hydrocholeresis induced by keto bile acids, and indicate the striking change in pharmacologic and physical properties caused by replacement of hydroxyl by a keto substituent in the bile acid molecule.


Prevention and treatment of pressure sores.


EMG study of quadriceps during resting stage of exercise.


Treatment of patients with frostbite.

Treatment of patients with frostbite.


High viscosity fluids for thermotherapy and graded exercise.


A weighted walker.

A weighted walker.


A comparison of biographical data of physical therapy students in California.


Liquid level detector for use by the blind.


A scanning electron microscope study of the papilla basilaris of Gekko gecko.


Effect of pH on the activity of nervous cholinesterases of the rat towards different biochemical and histochemical substrates and inhibitors.


Histochemical detection of the  -D-arabinopyranoside configuration using fluorescent-labelled concanavalin A.


Sterol metabolism. XXII. Gas chromatographic differentiation among cholesterol hydroperoxides.


The preparation of a glycopeptide-sepharose for affinity chromatography.


Fractionation of the whey proteins and casein of cow's milk on sephadex DEAE A-50 and A-25.


Chromatography of five cytokinins on an insoluble polyvinylpyrrolidone calumn.


Thin-layer chromatographic separation of diphenylindonyl-substituted thiohydantoin derivatives of amino acids.


Absence of pseudouridylic acid in the total ribonucleic acid extracts of wheat leaves.


Chromatographic analysis of isomeric isovalerate and isoamyl wax esters.


Gas-liquid chromatographic resolution of several protein amino acid enantiomers on a packed column.


Separation of  -apocarotenals and related compounds by reversed-phase paper and thin-layer chromatography.


The use of electron-acceptor reagents for the non-destructive detection of some phenothiazine derivatives on thin layers.


Laurell electrophoresis on cellulose acetate.


Quantitative preparation and gas chromatography of short and medium chain fatty acid benzyl esters (C 1 -C 12 ).


Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine.


Thin-layer chromatography of phenothiazine derivatives and analogues.


Treatment of intracranial metastatic lesions.


Psychiatric services and alcoholics.

Psychiatric services and alcoholics.


Health care, a right?

Health care, a right?


Bypass vein grafts to distal tibial or dorsalis pedis arteries. Case reports.


Measurement of bronchial elastance in resected sheep lungs.


An intragastric cardiac pacemaker.

An intragastric cardiac pacemaker.


Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude.


Relation between abnormalities in the chest radiograph and changes in pulmonary function in chronic bronchitis and emphysema.


Radiology compared with xenon-133 scanning and bronchoscopic lobar sampling as methods for assessing regional lung function in patients with emphysema.


Thrombo-embolic complications of the cloth-covered Starr-Edwards prostheses No. 2300 aortic and No. 6300 mitral.


Size of the diaphragm in chronic bronchitis.


Determinants of expiratory airflow in patients with chronic airways obstruction.


Resection for bronchial carcinoma in the elderly.


Pulmonary effects of acute exposure to nitrous fumes.


Lung volume and its subdivisions in normal and asthmatic males.


Atrial and ventricular pacing after open heart surgery.


Acetylcholine and cholinesterases (assays and light- and electron microscopial histochemistry) in different parts of the pituitary of rat, rabbit and domestic pig.


A positive donor-recipient identification system for a regional blood transfusion service.


Albumin preparations and placental alkaline phosphatase activity.


Responses of prolactin cells of two euryhaline marine fishes, Gillichthys mirabilis and Platichthys stellatus, to environmental salinity.


Laboratory proficiency in blood banking: the variability of blood bank reagents--1971 (a follow-up study).


A method for removing leukocytes from stored blood.


Preliminary screening and tentative identification of HL-A lymphocytotoxic antibodies in a hospital blood bank.


Scanning electron microscopy of the third ventricle of sheep.


Variations in the agglutinability of red blood cells from patients with hematologic disorders.


Social systems and the criteria of health as defined by the World Health Organization.


Electrophysiological-histological studies on some functional properties of visual cells and second order neurons of an insect retina.


Chronic marijuana use and psychosocial adaptation.


Elution of chromium label from preserved red blood cells transfused during surgery.


Paradoxical bleeding in intensively transfused hemophilics: alteration of platelet function.


Changing styles in psychiatric syndromes: a symposium.


Spectrum of albumin auto-agglutinins.

Spectrum of albumin auto-agglutinins.


No-suicide decisions: patient monitoring of suicidal risk.


Screen memories in a pair of monozygotic twins discordant for involutional depression and psychophysiological disorders.


A survey of attitudes of chairmen of departments of psychiatry toward community mental health.


Modern man and his instinct of workmanship.


Social psychiatric impairment: racial comparisons.


Drug abuse, sexual attitudes, political radicalization, and religious practices of college seniors and public school teachers.


Implications of the women's liberation movement for psychotherapy.


Black liberation, women's liberation.

Black liberation, women's liberation.


Functions of the lower-class partial family.


About psychiatry, psychiatrists, and social problems.


Countertransference reactions to violent patients.


Imipramine therapy and seizures: three children treated for hyperactive behavior disorders.


Alcohol-induced sexual impotence.

Alcohol-induced sexual impotence.


Quaalude alley: a one-way street.

Quaalude alley: a one-way street.


Participatory management in psychiatry.

Participatory management in psychiatry.


The responsibilities of psychiatry to medicine: a debate.


Position statement on community mental health centers.


Effect of hypercapnia on CSF turnover and blood-CSF barrier to protein.


Language disorders, convulsive disorder, and electroencephalographic abnormalities. Acquired syndrome in children.


Speed of decision-making processes in patients with unilateral cerebral disease.


Brain metabolism during hypoglycemia. Effect of insulin on regional central nervous system glucose and energy reserves in mice.


Spontaneous angiographic disapparance of a cerebral arteriovenous malformation. Third reported case.


Serum carnitine. An index of muscle destruction in man.


Amino acid abnormality in Sjögren-Larsson syndrome.


Internal cerebral vein thrombosis.

Internal cerebral vein thrombosis.


A test of Lippold's hypothesis.

A test of Lippold's hypothesis.


Investigation of the accumulation of fat in the kidneys of mice poisoned with carbon tetrachloride.


Metabolism, excretion and toxicology of trichloroethylene after inhalation. 1. Experimental exposure on rats.


Metabolism, excretion and toxicology of trichloroethylene after inhalation. 2. Experimental human exposure.


Phosphorylation of acetylcholinesterase in bovine blood by Paraoxon and Soman.


Reversible inactivation of extracellular thiaminase I in Bacillus thiaminolyticus. I. Inactivation by the primary substrate and reactivation by the secondary substrate.


Two interconvertible forms of L-type pyruvate kinase from rat liver.


M-type pyruvate kinase of leucocytes: an allosteric enzyme.


Multiple effects of ions on ATP: L-arginine and ATP: creatine phosphotransferases.


Purification and properties of an isoenzyme of arylsulphatase from Aspergillus oryzae.


Comparison of the kinetic parameters of Pseudomonas isoamylase and Aerobacter pullulanase.


Chymotrypsin-catalyzed reactions of phenyl hippurate with alcohols. Kinetic evidence for a binding site for nucleophiles.


Hexosaminidase activity of cultured human skin fibroblasts.


Maize leaf inorganic pyrophosphatase: isozymes, specificity for substrates, inhibitors, and divalent metal ions, and pH optima.


Reactions of P582 from Desulfotomaculum nigrificans with substrates, reducing agents and carbon monoxide.


-Aminolevulinic acid synthetase from cold-stored potatoes.


Dihydrofolate reductase induced by folic acid in cultured human cells.


Simulation of biphasic oxygen equilibrium curves of hemoglobin in the presence of small amounts of 2,3-diphosphoglycerate.


Demonstration of two forms of phenylalanine hydroxylase in human liver obtained at autopsy.


Some characteristics of partially purified human liver phenylalanine hydroxylase.


A hydraulic microdrive for the remote control of micromanipulation: economically constructed.


Brain scanning with a nuclear enterprises scinticamera IV.


Patient safety--class 3 equipment has advantages.


A "piped" automatic defibrillation system using one master supply unit.


Acute appendicitis presenting as gastroenteritis in an infant.


Severe staphylococcal infection in an infant.


Acute epidermal necrolysis in twins.

Acute epidermal necrolysis in twins.


The effect of anabolic hormones on the growth of undersized boys.


Acute bronchitis, chronic bronchitis and bronchiectasis.


Mortality of British coal miners in 1961.


Morbidity of British coal miners in 1961-62.


Use of radioisotopes in the study of textile workers with byssinosis and chronic lung damage.


A study of the acute and chronic changes in ventilatory capacity of workers in Lancashire cotton mills.


A survey of respiratory disease in cotton operatives. I. Symptoms and ventilation test results.


A survey of respiratory disease in cotton operatives. II. Symptoms, dust estimations, and the effect of smoking habit.


Relationship between sickness absence and length of service.


Computer simulation of industrial hazards.


Radiological changes in carpal and metacarpal bones and phalanges caused by chain saw vibration.


Employment Medical Advisory Service.

Employment Medical Advisory Service.


Industrial ammonia gassing.

Industrial ammonia gassing.


A radiographic technique for demontrating the causes of persistent nasality in patients with pharyngeal flaps.


Sandwich pushback and lateral pharyngoplasty.


Development and structure of the premaxillary deformity in bilateral cleft lip and palate.


One-stage reconstruction of the whole lower lip.


The treatment of giant cystic hygroma of the neck.


Reduplication of the mouth and mandible.


Dangerous patients.

Dangerous patients.


Pathology of malignant hyperpyrexia.

Pathology of malignant hyperpyrexia.


New cause of tennis elbow.

New cause of tennis elbow.


Occupational medicine?

Occupational medicine?


Speech defects in children aged 7 years: a national study. A series of screening procedures applied on a national scale by doctors, teachers, and health visitors showed that between 10% and 13% of British 7-year-old children born in one week in 1958 were reported as having an appreciable degree of speech impairment. Between 1% and 2% had a marked speech defect though hearing normally. This latter group of speech-defective children were more often male and of poor family background, and more were born towards the end of a long family. They were often at a disadvantage educationally and had more clumsiness and defects of vision and visuomotor co-ordination than the rest of the sample. The methods used for screening provided a reliable guide in the selection of children who require further investigation.


Early mobilization after myocardial infarction: a controlled study. During the years 1968-71 203 patients with proved myocardial infarction were admitted to the trial. Patients were mobilized either on day 10 (102 patients) or on day 20 (100 patients). All patients were kept in hospital for 30 days in order to ensure a detailed comparison of clinical course and laboratory data. In neither group was there a fatal complication and the differences in clinical outcome or laboratory data were statistically not significant. Half of the patients from each group were re-examined after an average of one-and-a-half years, and again no differences were observed. It is concluded that patients with an uncomplicated myocardial infarction may safely be mobilized after 9 days and discharged after three weeks.


Hyperinfection syndrome with Strongyloides stercoralis in malignant lymphoma. Hyperinfection with Strongyloides stercoralis occurred in three patients with malignant lymphoma. The probable cause in each case was alteration of the immune responses either as a result of the malignant lymphoma or by the treatment given. Though thiabendazole (Mintezol) has produced reasonable results in the treatment of the hyperinfection syndrome, preliminary data suggest that the new broad-spectrum anthelmintic levamisole (Ketrax) is more effective. All patients who live or have lived in an area where strongyloidiasis is endemic should be investigated to detect the presence of the nematode before and during treatment with drugs with immunosuppressive properties. In view of the high mortality with S. stercoralis hyperinfection, vigorous therapy should be instituted before the use of immunosuppressive drugs.


Role of the school eye clinic in modern ophthalmology. Routine sight tests for children at intervals throughout their school career are clearly important; three-quarters of those referred to the school eye clinics in this area had some ocular defect. It is probably no longer necessary for myopic schoolchildren to be treated by a consultant ophthalmologist after their initial examination.Forty-five per cent. of children referred to the school eye clinics in this area were found to have squint and/or hypermetropic/anisometropic/astigmatic refractive errors. Priority should be given to this group because of the association of amblyopia with these conditions. Their treatment requires closer association with the hospital ophthalmic department, perhaps even complete unity. Transfer of children at present seen in the school eye clinic to a hospital-based "children's eye clinic" would also fit in with a unified health service administration structure and be better placed to indicate, evaluate, and control future developments towards the prevention of amblyopia.


Significance of literacy in the performance of students in the first year of the Nottingham Medical Course. The "literacy" of a fresh intake of medical students as measured by standardized vocabulary tests has been measured and correlated with examination performance during the first year. Although most students lacked an upper social class upbringing, medical parents, or a classical education, the group performed to a high standard in the tests, comparable with an English honours intake. On the other hand, there appears to be no correlation between an extensive working vocabulary and the ability to perform well in any aspect of the course, apart from the community studies. A qualification in Latin confers no advantage at all on the aspiring doctor.


Coxsackie B virus and diabetes.

Coxsackie B virus and diabetes.


Anaesthesia in sickle-cell states.

Anaesthesia in sickle-cell states.


Radiography of potentially pregnant females.


Gastric ulcer after highly selective vagotomy.


Vitamins in illness.

Vitamins in illness.


Deaths associated with general dental anesthesia.


Working of the Mental Health Act.

Working of the Mental Health Act.


Suicide rate.

Suicide rate.


Radiological pseudotumour in chronic ulcerative colitis.


Digestive disease: the changing scene.

Digestive disease: the changing scene.


Side effects of the pill.

Side effects of the pill.


Cervical carcinoma in young women.

Cervical carcinoma in young women.


Toxicity of benorylate.

Toxicity of benorylate.


Gene order in species of Staphylococcus.


Degradation of polychlorinated biphenyls by two species of Achromobacter.


Utilization of  3 H-5-uridine for RNA synthesis in Ehrlich ascites tumour cells.


Amphibian cells in vitro. II. Effects of variations in medium osmolarity on a permanent cells line isolated from Xenopus.


Surface characteristics of macrophages, epithelioid and giant cells using scanning electron microscopy.


Comparison between chromosomal and nuclear sap RNA from Chironomus tentans salivary gland cells by RNA-DNA hybridization.


On the infleunce of 5-amino uracil on the cell cycle of root tip meristems.


On orientation of rhizoid outgrowth of Ulva mutabilis by applied electric fields.


Strontium deposits in isolated plant mitochondria.


Myelination in developing cultured newborn rat cerebellum inhibited by 5-bromodeoxyuridine.


Paradoxical effects of ouabain on the migration of peritoneal and alveolar macrophages.


Enhancement of RNA labeling in iris and lens by wounding cornea.


Centriolar changes induced by vinblastine sulphate in the seminiferous epithelium of the mouse.


Report of the Commission on Ethical and Religious Directives for Catholic Hospitals: Catholic hospital ethics.


A review and critique of the CTSA report.


A physician views the Directives.

A physician views the Directives.


Theologians view the directives.

Theologians view the directives.


The medical audit study--a tool for quality control.


Team approach to comprehensive health planning.


Half-lives of immunoglobulins IgG, IgA and IgM in the serum of new-born pigs.


The transfer of immunoglobins IgG, IgA and IgM from serum to colostrum and milk in the sow.


In vitro studies on the phagocytosis of Staphylococcus aureus by peritoneal macrophages of New Zealand mice.


The significance of circulating IgE. Correlation of amount of circulating reaginic antibody with cutaneous sensitivity in the rat.


The kinetics of mast cells in lymph nodes of immunized mice.


A new method for separating lymphocytes and granulocytes from human peripheral blood using programmed gradient sedimentation in an isokinetic gradient.


Episodic secretion of luteinizing hormone (LH) in adolescent patients with the syndrome of gonadal dysgenesis.


Gynecomastia, prolactin, and other peptide hormones in patients undergoing chronic hemodialysis.


Temporal rhythm in the response of urinary 17-OHCS to metopirone in Cushing's syndrome due to bilateral adrenal hyperplasia.


Forearm angiography during sustained isometric hand-grip contractions.


Serum androstenedione and testosterone levels during the menstrual cycle.


Congenital lipoid adrenal hyperplasia in an eight-year-old phenotypic female.


Clomiphene in the evaluation of the pituitary-gonadal axis in acromegaly.


The effect of clomiphene citrate on the 24-hour LH secretory pattern in normal men.


Studies of human neurophysin by radioimmunoassay.


Gastrointestinal absorption of iopanoic acid.


Cerebrospinal fluid flow alterations in the dog with chemical meningitis.


The field characteristics of the focal spot in the radiographic imaging process.


Antilipolytic effect of digoxin in the forearm of man.


The effect of prostaglandin E 2  on bile flow and the biliary excretion of iopanoic acid.


A preliminary observation on the protective action of acetazolamide against sodium diatrizoate-induced convulsions in the rabbit.


Plasma catecholamines in hypothyroidism and hyperthyroidism.


Heparin administration appears to decrease cellular binding of thyroxine.


Effects of ethinylestradiol and cyproterone acetate on androgen metabolism by the human prostate gland.


Angiographic evidence of stagnant flow zones in the carotid circulation of anesthetized dogs.


Interference of 21-deoxycortisol with cortisol assay methods.


Depletion of thyroid iodine during subacute thyroiditis.


Metabolic and cardiovascular effects of selective intracoronary injections of contrast media.


Estrogen-induced human luteolysis.

Estrogen-induced human luteolysis.


The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH).


Early detection of implantation using a radioimmunoassay specific for human chorionic gonadotropin.


The first component (C1n) of the complement system of the nurse shark (Ginglymostoma cirratum). I. Hemolytic characteristics of partially purified C1n.


The first component of complement in serum: evidence for a hitherto unrecognized factor in C1 necessary for internal activation.


Serum transmissibility of immune polioencephalomyelitis in C58 mice.


Rabbit immunoglobulin light chains: correlation of variable region sequences with allotypic markers.


Granulocyte chemotaxis: an improved in vitro assay employing  51 Cr-labeled granulocytes.


Enhancement of immunologically induced granule exocytosis from neutrophils by cytochalasin B.


Neutrophilic leukocytes in immunologic reactions in vitro: effect of cytochalasin B.


In vitro kinetics of intestinal secretory IgA secretion.


Enhancement of an anti-hapten antibody response by an antiserum to the carrier protein.


An evaluation of a dual-isotope method for the measurement of vitamin B 12  absorption.


Macroaggregated albumin studies of the coronary circulation in the dog.


In vitro studies of  99m Tc-pertechnetate binding by human serum and tissues.


Kinetics of  67 Ga compounds in brain sarcomas and kidneys of mice.


Improved xenon images with  127 Xe.

Improved xenon images with  127 Xe.


Increased focal uptake of radiocolloid by the liver.


Quantitative analysis of brain scans.

Quantitative analysis of brain scans.


Identification of iodine in a supraclavicular lymph node following lymphography: a fluorescent scan artifact.


Myocardial imaging with  13 NH 4+  and a multicrystal positron camera.


111 In-chloride: a new agent for bone marrow imaging.


False-positive liver scan due to breast prosthesis.


Changes in blood chemistries following a controlled exercise program.


Breast cancer detection in an employee health clinic.


Pectus excavatum (funnel chest) as an occupational disease.


A five-year mortality study of alcoholics.


Medical monitoring in industry.

Medical monitoring in industry.


Demise of the Council on Occupational Health.


Gallium fluoride poisoning.

Gallium fluoride poisoning.


Johnstone Memorial Lecture: occupational health--inaction or in action?


What kills and disables people who work?


Motor vehicle accidents and occupational health: the roads meet.


Talc: a possible occupational and environmental carcinogen.


The responsibilities of a surgeon.

The responsibilities of a surgeon.


Eating fresh coffee grounds: psychoneurosis or sub-clinical pellagra.


Superior sulcus tumor.

Superior sulcus tumor.


Vitamin B12--revisited: the Schilling test.


EKG of the month: isolated segmental obstruction, anterior descending coronary artery.


Establishment of state center for health statistics recommended.


The development of a ward information-management system.


A system approach to medical information.


Some sources and potential consequences of errors in medical data recording.


Recovery of rat adrenal amine stores after insulin administration.


Circular dichroic determination of the preferred conformation of nicotine and related chiral alkaloids in aqueous solution.


Lipid binding and mode of action of compounds of the dichlorodiphenyltrichloroethane type: a proton magnetic resonance study.


On the analysis of pharmacological experiments in terms of an allosteric receptor model.


Molecular structures of hallucinogenic substances: lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyamphetamine.


Binding of atropine and muscarone to rat brain fractions and its relation to the acetylcholine receptor.


Politics and medical care in Sweden: the Seven Crowns Reform.


Epidemiology of benign breast lesions: lack of association with oral contraceptive use.


Paternal transmission of maleness in XX human beings.


Learned control of cardiac rate and cardiac conduction in the Wolff-Parkinson-White syndrome.


Sex-determining genes and the Y-chromosome.


Simultaneous occurrence of "American Burkitt's lymphoma" in neighbors.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1973.


National security, budget trimming and medical science.


Lighting the way to control of heart function.


Medical metrication: U-100 insulin.

Medical metrication: U-100 insulin.


Hypertension and renal failure.

Hypertension and renal failure.


Plasmacytoma primary in the brain.

Plasmacytoma primary in the brain.


Scalded-skin syndrome in adults.

Scalded-skin syndrome in adults.


Pneumothorax and Horner's syndrome.

Pneumothorax and Horner's syndrome.


Interaction of bilirubin with human skin.


Labels for cholesterolopenic diets.

Labels for cholesterolopenic diets.


The tight-girdle syndrome.

The tight-girdle syndrome.


Reporting of adverse drug reactions.

Reporting of adverse drug reactions.


"Shopping around" for drugs.

"Shopping around" for drugs.


Rash claims re marihuana.

Rash claims re marihuana.


The loudness of noise.

The loudness of noise.


Proper use of hearing aids.

Proper use of hearing aids.


Fastidious editorial thought control?

Fastidious editorial thought control?


Radioprotective effect of Rauscher leukemia virus in the SJL-J mouse. II. Development of radioresistance and the distribution of mortality.


Cross-linkages in human serum albumin polymerized by gamma irradiation in solution.


Renal tumors in parabiosed irradiated rats.


Repair of DNA damage in ultraviolet-sensitive cells isolated from HeLa S3 cells.


Proton irradiation of beagle eyes. I. Si(Li) and thermoluminescent dosimetry of 20, 35, and 45 MeV protons.


The calculation of proportional counter energy-deposition spectra from experimental data.


Radiation-induced mixed-disulfide formation from cystamine and aliphatic disulfides in aqueous solution.


The effect of dietary fatty acids and tocopherol on the radiosensitivity of mammalian erythrocytes.


Effects of whole-body irradiation and hormones on drug metabolism in the liver endoplasmic reticulum.


Alterations in rubidium-86 extraction in normal mouse tissues after irradiation. An estimate of long-term blood flow changes in kidney, lung, liver, skin and muscle.


Electrocardiogram changes with intrauterine contraceptive device insertion.


Secretory rates of human chorionic gonadotropin by normal trophoblast.


New cancers arising in 1,563 patients with carcinoma of the cervix treated by irradiation.


Pelvic pneumography: procedure and technique.


Quality control for automated film processing.


Studies of the influence of estradiol and growth hormone on the hypophysectomized immature rat epiphyseal cartilage growth plate.


Sequential changes in total and free testosterone and androstenedione in plasma during spontaneous and Clomid-induced ovulatory cycles.


Accreditation process in the health professions and its relationship to radiologic technology.


One-year contraceptive follow-up of adolescent patients.


Management of breech presentation at term.


Thermoluminescence dosimetry: a practical advantage in radiation therapy. A further diversification for the radiologic technologist.


Vaginal versus abdominal tubal ligation. Study at Victoria General Hospital. Comparisons of two methods of sterilization on 250 patients at Victoria General Hospital, Nova Scotia, Canada between January 1968 and December 1970.  There were 85 vaginal procedures and 165 abdominal procedures; 50 cases were lost to follow-up.  Average age of the women was 35 years, average parity was 3.5 children.  Average hospital stay was 4.0 days with the vaginal approach and 6.5 days with the abdominal approach.  Hydrosalpinx was discovered in 3 women who had vaginal ligations, and in 2 who had abdominal ligations.  Menstrual changes were reported by 15 women; 8 had vaginal ligation, 7 abdominal ligation.  Dysmenorrhea was experienced by 5 women; 3 undergoing vaginal ligation and 2 abdominal ligation.  Morbidity rate with abdominal ligation was 3.2% and 8.3% with vaginal ligation.  Operative failure was 1.17% with the vaginal approach.  Menstrual irregularities, dysmenorrhea, dyspareunia, and hydrosalpinx seemed more frequent in the vaginal ligations.  Cost-wise the vaginal approach has the advantage but should be carried out on selected patients using a skilled staff.


Does the human fetal adrenal play a role in parturition?


Tuberculosis complicated by pregnancy.

Tuberculosis complicated by pregnancy.


"Glioma" of the uterus: a fetal homograft.


Clinical experience with the amniotic fluid lecithin-sphingomyelin ratio. I. Antenatal prediction of pulmonary maturity.


Caveats of antenatal diagnosis of Tay-Sachs disease.


Placental transfer of meperidine HCl. II.


Lipid metabolism in vitro by rabbit embryos during development.


Amniotic fluid levels of uric acid and creatinine in toxemic patients--possible relation to diuretic use.


Amnionic fluid D(-)- -hydroxybutyrate and the dysmature newborn infant.


1,3-Bis (2-chloroethyl)-1-nitrosourea: effects on advanced ovarian carcinoma.


Effect of maternal administration of diazepam on the bilirubin-binding capacity of cord blood serum.


Intrauterine herpes simplex infection.

Intrauterine herpes simplex infection.


"Shock lung".

"Shock lung".


Disseminated intravascular coagulation associated with tetracycline-induced hepatorenal failure during pregnancy.


Use of the Babcock clamp.

Use of the Babcock clamp.


Treatment of urogenital trichomoniasis.

Treatment of urogenital trichomoniasis.


Karman catheter.

Karman catheter. In their recent communication in brief on the Karman catheter, Beric and his coauthors ignored 2 recent papers on the use of this flexible cannula.  They reported retention of tissue in large numbers of patients even early in pregnancy but did not note the quantity of the retained material, without which its significance cannot be evaluated.  Goldsmith and Margolis had no such problems, while Lewis and colleagues reported retained tissue, primarily in their initial patients.  This problem resolved itself with further experience and increased expertise.  In carrying out an abortion procedure, great stress must be placed on efforts to decrease cervical trauma and subsequent cervical incompetence.  Data from Eastern Europe, Japan, and the United Kingdom suggest an increase in premature labor subsequent to induced abortion.  Narrow-diameter flexible cannulas can play an important role in early abortion and can be used into the 9th week of pregnancy (from the date of the last menstrual period) without problem.  It is most important to the welfare of women that use be made of such minimum dilatation techniques in early abortion procedures.


Treatment of spasticity with dantrolene sodium.


Effect of radical neck dissection on total rehabilitation of the laryngectomee.


Electromyographic investigation of the relative activity among four components of the triceps surae.


Evaluation of ultrasonic B-mode scanning in the diagnosis of renal masses.


Bilateral hypernephroma.

Bilateral hypernephroma.


Tumors of the ureter. Problems in diagnosis.


Diagnostic ultrasound scanning: a valuable aid in radiation therapy planning.


An electrostatic printer display for computerized scintiscans.


Co 60  simulator.

Co 60  simulator.


A new method of aligning a light localizer-x-ray beam.


New methods to facilitate radiotherapy planning and treatment, including a method for fast production of solid lead blocks with diverging walls for cobalt 60 beam.


Updating the Manchester system for afterloading.


Experience with californium 252 in clinical radiotherapy.


A comparison of technetium 99M and iodine 123 for thyroid imaging.


1972 presidential report to the membership of the American Radium Society, Philadelphia, Pennsylvania.


Illustration of isodose curves with the application of the Sabattier effect.


Radiation hepatitis induced by abdominal irradiation with the cobalt 60 moving strip technique.


Primary plasmocytoma of the spleen.

Primary plasmocytoma of the spleen.


Radiation therapy of desmoid tumors.

Radiation therapy of desmoid tumors.


Xeromammography--an improved diagnostic method. A review of 250 biopsied cases.


Hypernephromas with massive arteriovenous fistulas.


Safety of viable, avirulent Leptospira pomona vaccine in pregnant cows.


Renal leptospirosis: challenge exposure to vaccinated and nonvaccinated cattle to Leptospira icterohaemorrhagiae and Leptospira canicola.


Transmission of streptococcic lymphadenitis by carrier swine.


Strongyloides ransomi: detecting drug action on larvae in porcine tissue.


Microscopic lesions in fetuses of ewes ingesting locoweed (Astragalus lentiginosus).


Chlorine-36 as a continuing indicator of extracellular fluid volume in the dog.


Effects of hypertonic solutions on cerebrospinal fluid pressure in the lateral ventricle of the dog.


Certain effects of sampling and storage on canine blood of different oxygen tensions.


Elimination kinetics of pentobarbital in nephrectomized dogs.


Microtechnique for the study of ferro- and erythrokinetics in the rat.


Biochemical and hematologic values in male Holstein-Friesian calves.


A modified supraorbital approach to hypophysectomy in the pig.


Technique for chronic cannulation of the canine thoracic duct.


Identification of type D strains of Pasteurella multocida with acriflavine.


Quantitative studies on motoneurons: hypoglossal neurons in the boa constrictor, Constrictor constrictor.


The fine structure of pacemaker cells in the pig renal calices.


A comparative ultrastructural analysis of the third cerebral ventricle of the North American mink (Mustela vison).


The ultrastructure of the principal cells and intraepithelial leucocytes in the initial segment of the rat epididymis.


Changes in distribution of lipid, glucose-6-phosphate dehydrogenase and malate enzyme within the liver lobule of the rat during adaptive hyperlipogenesis.


An autoradiographic study of the utilization of tritiated uridine by osteoblasts of young mice.


Ossicular replacement prosthesis. Clinical notes.


Improved middle ear inflating device.

Improved middle ear inflating device.


Stability of hearing over an eight-year period following wire-vein stapedectomy for otosclerosis.


Quantification of the "in vitro" development of the mouse embryo inner ear.


Development of sensory structures in organ cultures of the twelfth and thirteenth gestation day mouse embryo inner ears.


Sudden deafness and labyrinthine window ruptures. Audio-vestibular observations.


Eye color in darkly pigmented basal-cell carcinomas and malignant melanomas. An aid in their clinical differentiation.


An unusual form of alerting mechanism in electronystagmography.


Concentration of antibiotics in sinus secretions. Doxycycline and spiramycin.


Proflavine staining of the skin demonstrated by fluorescent microscopy.


Epidermal changes in vitamin B 12  deficiency.


Industrial contact dermatitis. Effect of the riot control agent ortho-chlorobenzylidene malononitrile.


Subcutaneous dermoid cysts.

Subcutaneous dermoid cysts.


Salivation testing in traumatic facial paralysis.


Annulus migrans. Identical lesions in pustular psoriasis, Reiter's syndrome, and geographic tongue.


Testing for "recruitment" by electrocochleography. Preliminary results.


The multiple lentigines syndrome.

The multiple lentigines syndrome.


Amino acid composition of human nasal mucus. Normal subjects.


Bone destruction of a distal phalanx caused by periungual warts.


Blood flow in otorhinologic tissue after histamine and papaverine.


Ossicular chain transplantation in cats.


Ichthyosis hystrix. Epidermolytic hyperkeratosis; discordant in monozygotic twins.


Progressive, atrophying, chronic granulomatous dermohypodermitis. Autoimmune disease?


Perilymph displacement by cerebrospinal fluid in the cochlea.


Vitamin A acid in treatment of oral lichen planus.


Keratosis lichenoides chronica.

Keratosis lichenoides chronica.


Static lung volumes in singers.

Static lung volumes in singers.


Mucous glands in the middle ear and osseous Eustachian tube.


A critical look at therapy for the brown recluse spider bite.


Stability of nitrosourea solutions.

Stability of nitrosourea solutions.


Massive pulmonary haemorrhage in the newborn. A changing pattern.


Controlled trial of fresh frozen plasma in asphyxiated low birthweight infants.


Renal tubular and papillary necrosis after dehydration in infancy.


Abnormalities of insulin and growth hormone secreton in children with coeliac disease.


Development of visual acuity.

Development of visual acuity.


Plasma digoxin levels in infants.

Plasma digoxin levels in infants.


Homocystinuria. Reduced folate levels during pyridoxine treatment.


Familia neuroblastoma: report of two sib pairs.


Glomerulonephritis associated with Staphylococcus albus in a Spitz Holter valve.


Muscular performance in cystic fibrosis patients and its relation to vitamin E.


Syndrome of growth resistance, obesity and intellectual impairment with precocious puberty.


The winged bean (Psophocarpus palustris Desv.) in the treatment of kwashiorkor.


The composition of chinchilla milk.

The composition of chinchilla milk.


Covert bacteriuria of childhood. A clinical and epidemiological study.


The effect of a low-fat maternal diet on neonatal rats.


Perinatal mortality, growth and survival to weaning in offspring of rats reared on diets moderately deficient in protein.


The effect of the chemical composition of maize plant lignin on the digestibility of maize stalk in the rumen of cattle.


Effect of an adequate-protein diet after a low-protein diet on protein catabolism in growing rats.


Degradation of riboflavin by alimentary bacteria of the ruminant and man: production of 7,8-dimethyl-10-carboxymethylisoalloxazine.


Notes on a deamination method proposed for determining "chemically available lysine" of proteins.


Relationships between copper, zinc and iron in the plasma, soft tissues and skeleton of the rat during Cu deficiency.


Short-term effects of feeding rats with glucose syrup fractions and dextrose.


Lesions produced by copper deficiency in neonate and older rats.


Hyperactive children.

Hyperactive children.


Treatment of malignant melanoma.

Treatment of malignant melanoma.


Particles in veins.

Particles in veins.


Awareness of tuberculosis.

Awareness of tuberculosis.


Unexpected deaths of babies.

Unexpected deaths of babies.


Learning to be a drinker.

Learning to be a drinker.


Interactions between sympathomimetic amines and antidepressant agents in man. Intravenous infusions of phenylephrine, noradrenaline, adrenaline, and isoprenaline were given to healthy human volunteers after five to seven days on phenelzine, tranylcypromine, or imipramine, and cardiovascular responses were compared with those observed under control conditions. With monoamine oxidase inhibitors there was a 2-2(1/2) fold potentiation of the pressor effect of phenylephrine, but no clinically significant potentiation of cardiovascular effects of noradrenaline, adrenaline, or isoprenaline. With imipramine there was potentiation of the pressor effects of phenylephrine (2-3 fold), noradrenaline (4-8 fold), and adrenaline (2-4 fold); there were dysrhythmias during adrenaline infusions, but no noticeable or consistent changes in response to isoprenaline.Noradrenaline and adrenaline in amounts contained in local anaesthetics used in dentistry are not likely to be significantly potentiated in otherwise healthy patients receiving monoamine oxidase inhibitors. Hazardous potentiation of their cardiovascular effects might occur in patients receiving tricyclic antidepressants.Our observations do not indicate that the hazards associated with isoprenaline inhalation by bronchial asthmatics would be increased by coincident therapy with a monoamine oxidase inhibitor or tricyclic antidepressant.


The wounded uterus: pregnancy after hysterotomy. Despite contraceptive advice, a high proportion of patients who have had a pregnancy terminated by hysterotomy became pregnant again within a short space of time. Fifty-three such pregnancies have been studied, and a substantial risk of rupture of the uterus was demonstrated in 14 cases where the scar was thin. Rupture, impending rupture, or presumptive rupture occurred in three of these cases. Nevertheless successful vaginal delivery occurred in about 80% of cases. The infants so produced were often small for dates. Due weight should be given to the risks of subsequent early pregnancy and uterine rupture before terminating a pregnancy by the operation of hysterotomy without sterilization.


Morbidity from acute carbon monoxide poisoning at three-year follow-up. Seventy-four survivors of acute carbon monoxide poisoning were followed up for an average of three years. In eight patients gross neuropsychiatric damage was directly attributable to the poisoning. Three patients had committed suicide and eight had died from other causes. Morbidity and mortality in those deliberately and accidentally poisoned was approximately equal.Of 63 patients alive at follow-up eight showed an improvement and 21 (33.3%) a deterioration of personality after poisoning, and 27 (43%) reported a subsequent impairment of memory. Deterioration of personality and memory impairment were highly correlated. The level of consciousness on admission to hospital in the acute phase of poisoning correlated significantly with the development of gross neuropsychiatric sequelae. These findings emphasize the importance of prompt and efficient treatment of carbon monoxide poisoning and the need to follow-up all cases in the anticipation of a relapsing course or the development of sequelae.


Serum alkaline phosphatase and rickets in urban schoolchildren. Among 569 schoolchildren (386 boys and 183 girls) aged 14-17 years, 233 had serum alkaline phosphatase values of 30 K.A. units or greater. There was no significant difference in the results in Asian, white, or West Indian children. The mean values were significantly greater in boys than girls and both showed a fall in mean values with increasing age. Radiological rickets occurred in at least 4% of the survey, and was more common in Asians. Low calcium and high hydroxyproline excretion in most of those investigated and the response to vitamin D therapy suggests that most children with alkaline phosphatase levels above 30 K.A. units have rickets.Since the decline of the widespread supplementation of the diet with vitamin D, the demands of the physiological growth spurt for extra vitamin D in adolescents already on a borderline intake may be responsible for the great increase in "biochemical" rickets. Once the growth spurt is over the condition subsides but the results of impaired growth or permanent pelvic deformity will not necessarily be eradicated.


Abnormal excretion of corticosteroid sulphates in patients with breast cancer. In a preliminary study, the 24-hour urinary excretion of corticosteroid sulphates and free cortisol have been measured in a group of patients with breast cancer and compared with the excretion of the same compounds in a group of normal women of similar age. Excretion of corticosteroid sulphates in the breast cancer group was found to be markedly raised. In a small number of patients with localized cancer of sites other than the breast the level of corticosteroid sulphate was not raised. If proved metastases were present a noticeable rise was observed.


Pleural effusion with pancreaticopleural fistula. Three patients with pleural effusion were found to have pancreaticopleural fistulas passing through an opening in the diaphragm are reported. In one case the effusion was purulent and originated from an abscess of the pancreas. Retrograde pancreatography during operation defined the course of the fistula. In two other cases the fistula was demonstrated by radiography after intrapleural injection of contrast medium. The diagnostic importance of injecting contrast medium early into the pleural cavity in cases of effusion rich in amylase, before lung expansion obscures the fistula, is emphasized. Cases of pancreaticopleural fistula may be commoner than supposed.


Skin ulceration caused by Salmonella dublin.


Ocular injuries caused by airgun pellets: an analysis of 105 cases. One hundred and five cases of airgun pellet injuries of the eye have been analysed. The average age was 14 and the male to female ratio 7.5:1. Forty-five patients had final visual acuities of 6/18 or less in the injured eye and 19 of these had the eye removed. The two main causes for poor vision were retinal damage and cataract. One patient became completely blind after sympathetic ophthalmitis arising 11 years after the injury. The pellet lodged in the orbit in 14 cases and three of these, together with one who had an intraethmoidal pellet, were investigated for abnormal lead levels in blood and urine. The results were normal.The circumstances of the injury were obtained in 12 cases and most involved careless handling of a gun. Instruction of children and parents in schools and on television, rather than stricter legislation, is suggested as a means of prevention.


Mumps.

Mumps.


Prophylactic internal fixation of secondary neoplastic deposits in long bones. The notes and radiographs of 19 patients who had pathological fractures of long bones due to secondary neoplastic deposits were reviewed. Involvement of over half of the cortex is recommended as an indication for prophylactic internal fixation to prevent the development of a pathological fracture. Eight patients were treated successfully in this way. A notable secondary effect of prophylactic internal fixation was the considerable reduction in pain at the site of the lesion.


Future of the BMA.

Future of the BMA.


An integrated child health service.

An integrated child health service.


Non-pharmacological influences on therapeutic efficacy.


Nitrazepam nightmares.

Nitrazepam nightmares.


Nurses for nursing.

Nurses for nursing.


Care of the dying.

Care of the dying.


Anthrax.

Anthrax.


Lead poisoning from contaminated opium.

Lead poisoning from contaminated opium.


Magnetic needle dish.

Magnetic needle dish.


Treatment of status asthmaticus.

Treatment of status asthmaticus.


Immunological responses in pregnancy.

Immunological responses in pregnancy.


Role of pacing after myocardial infarction.


Safety-belt snag.

Safety-belt snag.


Compensation for personal injury.

Compensation for personal injury.


Cutaneous sarcoidosis in venepuncture sites.


Drugs in infertility.

Drugs in infertility.


Psychiatric day care.

Psychiatric day care.


Largest award for medical negligence.

Largest award for medical negligence.


Intramuscular injection and coagulation defects.


Serum lithium estimations.

Serum lithium estimations.


Meiosis of ova from polyovular (C58-J) and polycystic (C57 L-J) strains of mice.


Scanning electron microscopic study of the human fallopian tube. 3. The effect of midpregnancy and of various steroids. The scanning electron microscope was used to examine fallopian tubes removed from 18 women including 3 on the low dose progestin contraceptive .5 mg megestrol acetate, 3 on different combined oral contraceptives, 3 fertile and 3  postmenopausal women on .05 mg ethinyl estradiol, 3 women 18-20 weeks pregnant, and 3 transsexuals injected monthly with 250 mg testosterone enanthate.  The microscope revealed few differences in cell distribution or structure.  More ciliated cells, usually located on edges of plicae, and fewer secretory cells were found in the ampulla and infundibulum than the isthmus and intramural portions of the endosalpinx.  Subjects taking progestogen, or in midpregnancy had a normal distribution of ciliated cells, but the cilia appeared drooping and granulated.  Both fertile and postmenopausal subjects taking estrogen had tall, vigouous cilia.  Only testosterone decreased the number of ciliated cells in the distal tube significantly.


Biologic changes induced by unilateral intrauterine instillation of quinacrine in the rat and their reversal by either estradiol or progesterone.


Infertility of rabbit testicular spermatozoa collected in their native fluid environment.


Effect of intrauterine copper on the uptake of estradiol-C 14  by rat tissues. To study the mechanism of intrauterine copper contraceptive action, 1 uterine horn of test rats was implanted with copper wire, the other was used as control.  The animals were injected with carbon-14 labelled estradiol and the concentrations in tissues were assayed.  There was no difference in estradiol uptake between the 2 hours until 4 weeks postinsertion when the copper-bearing horn showed a marked increase.  Upon ovariectomy, no difference in estradiol uptake was noted between the 2 horns, somewhat eliminating the possibility of missing early copper-induced increased uptake due to endogenous estradiol levels in excess amounts for saturation of  receptor sites.  Since the contraceptive properties of copper are manifested rapidly, the late increase in estradiol uptake suggests that primary antifertility action is not dependent upon this estrogenic effect.  The histologic change of intense proliferation in the mucosal stroma in the areas of direct contact with the copper may account for the later increase in estradiol uptake.


Influence of norepinephrine on the motility of the human vas deferens: a new hypothesis of sperm transport by the vas deferens.


Workshop airs patients' rights.

Workshop airs patients' rights.


Hospital-based battered child team.

Hospital-based battered child team.


Study analyzes effects of merger.

Study analyzes effects of merger.


Staff attitudes toward clinical pharmacy.


'Rules of the road' for sales reps.

'Rules of the road' for sales reps.


Menu forms cheaper by computer.

Menu forms cheaper by computer.


Central State Hospital extends CAMP usage.


Programs for equal employment opportunity.


Reducing linen costs: a systems approach.


Education and the hospital: developing patients' knowledge of health.


Education and the hospital: continuing education for lab personnel.


Education and the hospital: BSA organizes careers' programs.


Food service: more training programs recommended.


Nursing: shared training becomes a reality.


Staff privileges and the hospital's liability to patients.


Health care education for the community.


Education and the hospital: responsibility for management and financing.


Education and the hospital: cost of hospital-based education.


Education and the hospital: laboratory for medical education.


Education and the hospital: hospitalwide education and training.


Education and the hospital: dual responsibility for allied manpower training.


Education and the hospital: computers in nursing education.


Resources for health. The developmental process and new directions for health resources: a summary.


Patterns of drug usage among university students. V. Heavy use of marihuana and alcohol by undergraduates.


Student apathy--1970's style.

Student apathy--1970's style.


Animals in university buildings?

Animals in university buildings?


Is drug abuse a fading fad?

Is drug abuse a fading fad?


Users and nonusers of college counseling and psychiatric services.


The role of college health in planning for Health Maintenance Organizations.


A new system for entrance health evaluations.


Cigarettes and the college senior.

Cigarettes and the college senior.


Health information and the college student.


The development of a coalition of national health organizations.


Bridge over troubled waters: the experiences of a nonclinical association between staff psychiatrist and students.


The costs and effects of a student health-aide program.


An innovative model for counseling services on a university campus.


Pregnancy on a university campus.

Pregnancy on a university campus.


History of psychiatric disorder and risk of academic failure in freshman.


A survey of contraceptive practices and attitudes of unwed college students.


A time for more, not less, health education.


A peroxidase-mediated, streptococcus mitis-dependent antimicrobial system in saliva. H(2)O(2) formation by Streptococcus mitis was measured by the catalase-dependent conversion of [(14)C]formate to (14)CO(2) ; it was optimal at pH 6.0-6.5 and required glucose. The H(2)O(2) formed by S. mitis could be employed as a component of an antimicrobial system that also included lactoperoxidase (LPO) and either iodide or thiocyanate ions in the concentrations present in saliva. The antimicrobial effect of the LPO-iodide-S. mitis system was measured by the decrease in the viable cell count of the target organisms (Escherichia coli, Staphylococcus aureus, Candida tropicalis). The antimicrobial effect of the LPO-thiocyanate-S. mitis system was measured by the decrease in the rate of growth or the rate of uptake of [(14)C]valine by the target organisms (E. coli, S. aureus). Mixed or parotid saliva could replace LPO and thiocyanate ions in the S. mitis-dependent inhibition of bacterial growth and valine uptake. The presence in saliva of a peroxidase-mediated, antimicrobial system dependent on microbial metabolism for H(2)O(2) and its role as a natural host defense mechanism are considered.


A scanning and transmission electron microscope study of antigen-binding sites on rosette-forming cells. The ultrastructure of binding sites in rosette-forming cells of mice after immunization with sheep red cells was studied by means of scanning and transmission electron microscopy. It was found that the red cells were bound to the lymphocyte surface in circumscribed, immunoglobulin-containing areas, consistent with a spotlike or patchy distribution of antigen-binding immunoglobulin receptors. In these contact areas the cell membranes formed a gap of 80 A (range 75-90 A) which exhibited electron-opaque bridges at high magnification. These results are discussed in the light of the recent recognition of the formation of immunoglobulin spots on the lymphocyte surface after antigen contact. Morphological details suggest that the same mechanism is operating in rosette formation, possibly including the movement of the contact areas on the lymphocyte membrane.


Consequent intrafamilial immunization for DL-A haplotyping in canines. A procedure of intrafamilial immunization is described for production of antisera recognizing DL-A haplotypes. In a colony consisting of 1 sire, 6 bitches, and 67 offspring all haplotypes could be accurately allocated. In the colony the observed reaction frequencies of the antisera are in agreement with mendelian codominant inheritance. Mixed lymphocyte culture tests confirmed the accuracy of the serologic typing and the presence of homozygous individuals within the colony. Further evidence is presented supporting the presence of two or more subloci within the DL-A system. Colonies of canines such as the one described should provide a sensitive system for evaluating interaction between serologic DL-A typing, MLC reactivity, and immune response genetics in a nonrodent species which is not highly inbred.


Production of TL antibody by mice immunized with TL- cell populations. A possible assay for thymic hormone. TL(-) mice make TL antibody when immunized with spleen or bone marrow cells from TL(+) donors, despite the fact that these cells do not express TL antigen. This has been shown to depend on maturation of TL(-) precursors, contained in the inoculum, into TL(+) cells under influence of the recipient's thymus; the differentiated TL(+) cells then evoke production of TL antibody.


"Respice--prospice".

"Respice--prospice".


Calorimetric investigation of the association of various purine bases in aqueous media.


Degeneration of white matter in hypoxia, acidosis and edema.


The fine structure of ependymoblastoma.

The fine structure of ependymoblastoma.


Nasal fractures. Their occurrence, management and some late results.


Haemangioma of the mandible.

Haemangioma of the mandible.


Cholelithiasis in childhood.

Cholelithiasis in childhood.


Solitary vascular tumour of duodenum (haemangioendothelioma and-or haemangiopericytoma).


Identification of the facial nerve in parotid surgery.


Enuresis.

Enuresis.


Conservative management of renal artery embolus.


Renal artery aneurysms and hypertension.


Hypertension from renal tuberculosis: operative cure predicted by renal vein renin.


Acute renal insufficiency following oral cholecystography.


Pyonephrosis with pneumoureteropyelogram.


Unsuspected primary cortical renal cell carcinoma presenting as a metastatic subepithelial pelvic filling defect.


Dual renal cell carcinomas in a unilateral polycystic kidney.


Transitional cell carcinoma in bilateral multiple renal cystic disease.


Simplified introductions of ureteral catheters.


The effect of gravity on ureteral peristalsis.


Ureteral ectopia: report of 39 cases.

Ureteral ectopia: report of 39 cases.


The pathogenesis of urinary tract calculi occurring after ileal conduit diversion. I. Clinical study. II. Conduit study. 3. Prevention.


Complications, results and problems of ileal conduit diversions.


Urinary tract reconstruction following ileal conduit diversion.


Adenocarcinoma of the colon complicating ureterosigmoidostomy: a case report and review of the literature.


Intravesical hydrostatic pressure treatment: new method for control of bleeding from the bladder mucosa.


Perforation of the bladder: a complication of long-dwelling Foley catheter.


Perivesical lipomatosis.

Perivesical lipomatosis.


Chronic electrical stimulation of the paraplegic bladder.


Review of the management of 140 cases of exstrophy of the bladder.


The upper limits of hopeful application of radical cystectomy for vesical carcinoma: does nodal metastasis always indicate incurability?


Evaluation of urinary cytology as an indicator of bladder neoplasia in mice.


The surgical treatment and prevention of urinary incontinence associated with disturbance of the internal urethral sphincteric mechanism.


Fertility in patients treated for malignant testicular tumors.


Intrapelvic vas ligation at the time of prostatectomy. Vasectomy is frequently done with a prostatectomy to protect the patient epididymitis.  The technique used for intrapelvic ligation during a suprapubic prostatectomy was described.  The advantages of this technique over the transcrotal method are that the patient is saved 2 additional incisions and the incidence of infection is also decreased.


Surgical treatment for chyluria.

Surgical treatment for chyluria.


Benign ureteral tumors in childhood: a case report and a plea for conservative management.


Immunoglobulin excretion in women with recurrent urinary tract infection.


Evaluation of 80 cases of ileal conduits in children: indication, complication and results.


An inexpensive cooled recirculating system for the maintenance of marine flat fish.


Urinary tract calculi in children.

Urinary tract calculi in children.


Some clinical observations on the eyes of Sprague-Dawley rats.


Ancillary equipment for isolators. 1. A sealed sachet transfer unit.


Ancillary equipment for isolators. 2. A food transfer unit.


Ancillary equipment for isolators. 3. A device for the collection of blood samples externally.


Carcinogenicity of wood shavings.

Carcinogenicity of wood shavings.


The effect of the sex of litter-mates on the subsequent behaviour and breeding performance of cross-fostered rats.


Oncological and survival reference data for NZO-B1 inbred mice.


The effect of mating female rats at 35 or 80 days of age on pup production and maternal weight.


A simple device for indirect measurement of blood pressure in mice.


The effect of repeated cisternal puncture and withdrawal of cerebro-spinal fluid in the dog.


Survey of Aspergillus species associated with the human respiratory tract.


Fatty acid synthesis in Trichophyton rubrum.


Problems and challenges in rehabilitation of patients with acute myocardial infarction.


Physiology of exercise and physical conditioning in normals.


Exercise therapy in convalescence from acute myocardial infarction.


Physical conditioning in patients after myocardial infarction. Results of a comparative study and 9 years follow-up.


Fields WS, Bell RM, Ellingson RJ, Garrett HE, Goldberg HI, Janeway R, Miale A Jr,+MIALE A JR, Schechter MM, Sweet WH, Van Dyke JL,+VANDYK JL, Waltz AG:Special procedures and equipment in the diagnosis and management of stroke.


Natural history of stroke in Rochester, Minnesota, 1955 through 1969: an extension of a previous study, 1945 through 1954.


Cerebrovascular regulation in preganglionic and postganglionic autonomic insufficiency.


Familial incidence of cerebral hemorrhage.


Summary of the Sixth Salzburg Conference on Cerebral Vascular Disease, September 27 to October 1, 1972, Salzburg, Austria.


Increased binding of norepinephrine by nerves to cerebral blood vessels: evidence from the effects of reserpine on nerves to cerebral and extracerebral blood vessels.


Evidence for the direct effect of adrenergic drugs on the cerebral vascular bed of the unanesthetized goat.


Effects of blood gases on the pressure-flow relationships in canine cerebral circulation.


The effects of intra-arterial histamine on blood flow in the internal and external carotid artery of man.


Acute changes in blood pressure following vascular diseases in the brain stem.


Detecting carotid occlusive disease by thermography.


EEG and arteriographical findings in carotid artery transient ischemic attacks (TIAs).


Cytomorphometry of sarcoplasmic reticulum in extrinsic eye muscles of the teleost (Tinca tinca L.).


Long link induction between the microtubules of the manchette in intermediate stages of spermiogenesis.


Safeguarding children in automobiles.

Safeguarding children in automobiles.


Infantile polycystic disease of the kidney.


Patterns of brain damage in infants and children with congental heart disease. Association with catheterization and surgical procedures.


Experience on an adolescent inpatient division.


Lomotil (diphenoxylate and atropine) intoxication.


Concealed penis. Another complication of circumcision.


Clinical significance of tyrosinemia of prematurity.


Perinatal sudanophilic leukodystrophy.

Perinatal sudanophilic leukodystrophy.


Prenatal diagnosis of trisomy 18. Pathologic findings in 20-week conceptus.


Hyperlipoproteinemia and pancreatitis.

Hyperlipoproteinemia and pancreatitis.


Amyloidosis and multiple myeloma. A reevaluation using a control population.


Severe cardiac failure in a chronic alcoholic.


Alpha 1  antitrypsin deficiency in association with both cirrhosis and chronic obstructive lung disease in two sibs.


Herpes simplex encephalitis in an anergic patient.


Renal failure in intracranial lesions. Evidence of function of juxtamedullary nephrons.


Erythropoietic protoporphyria with features of a sideroblastic anaemia terminating in liver failure.


Familial hyperglycinuria. New defect in renal tubular transport of glycine and imino acids.


Foramen of Morgagni hernia with volvulus of the stomach.


Diagnose this unusual case in gastroenterology.


Diffuse esophageal spasm.

Diffuse esophageal spasm.


Multiple leiomyomas of the esophagus.

Multiple leiomyomas of the esophagus.


Roentgen significance of the duodenocolic relationships: an anatomic approach.


Significance of ileus in perforated viscus.


Angiographic findings in villous tumors of the colon.


Colonoscopy and double contrast barium enema examination in chronic ulcerative colitis.


Genitourinary complications of granulomatous bowel disease.


Retrorectal cysts of developmental origin.


Angiographic findings in pneumatosis cystoides intestinalis.


Arteriographic diagnosis of intussusception. Three case reports.


Malposition and displacement of the bowel in renal agenesis and ectopia: new observations.


Intestinal capillariasis: a new cause of a malabsorption pattern.


Combined occurrence of retropneumoperitoneum and pneumoperitoneum.


Tuberculous mesenteric lymphadenitis; with emphasis on angiographic findings.


Scanning of the hepatic blood pool in liver amebiasis.


Nonoperative retained biliary tract stone extraction. A new roentgenologic technique.


Routine tomography in gallbladder nonvisualization. A method for extended positive diagnosis.


Intravenous cholangiography. An experimental evaluation of several currently proposed methods.


Combined percutaneous transhepatic cholangiography (PTC) and selective visceral angiography (SVA) in obstructive jaundice.


Evaluation of renal function following double dose infusion intravenous cholangiography.


Complications of percutaneous transhepatic cholangiography (PTC).


Differential diagnosis of pancreatic calcification.


Detection of malignant disease by peroral retrograde pancreatico-biliary ductography.


Of dogs and frogs and cholecystokinin.

Of dogs and frogs and cholecystokinin.


A family study of ulcerative colitis. With particular reference to ankylosing spondylitis and sacroiliitis.


Pneumococcal arthritis.

Pneumococcal arthritis.


Elimination of fibrinogen from synovial joints.


Ultrastructure of a mycoplasma recovered from the bone marrow in systemic lupus erythematosus.


Knee arthropathy secondary to Mycobacterium scrofulaceum.


Salicylate-induced consumption coagulopathy.


Breeding experiments on the frequency of adjuvant arthritis in the rat.


Articular cartilage in corn oil-induced lipoarthrosis.


Absorption and retention of iron in rheumatoid arthritis.


Kinetics of iron deposition in rheumatoid joints.


Inheritance of primary articular chondrocalcinosis.


Neurological abnormalities complicating sub-foraminal osseous disease in chronic rheumatoid arthritis.


Treatment of dislocations in the cervical spine in rheumatoid arthritis and ankylosing spondylitis complicated by signs of cord compression.


Effects of phenylbutazone on the metabolism of C14-cortisol.


Mechanism of action of some anti-rheumatic drugs in allergic blood diseases.


Mobility of the metacarpophalangeal joints in normal subjects and in rheumatoid patients.


Rheumatoid arthritis, typus robustus.

Rheumatoid arthritis, typus robustus.


Tangential X-ray of the forefoot in rheumatoid arthritis.


Mitral valve disease and open heart surgery in osteogenesis imperfecta tarda.


Heart block with infected cardiac rheumatoid granulomas.


Atrial function after cardioversion for atrial fibrillation.


In search of causes of ischaemic heart disease.


Haemodynamic characteristics of systemic arterial blood supply to the lungs.


Two cases of endocardial fibroelastosis--possible x-linked determination.


Natural history of valvular aortic stenosis.


Pseudomonas cepacia endocarditis treated with co-trimoxazole and kanamycin.


Haemodynamic effect of deslanoside at rest and during exercise in patients with chronic bronchitis.


Exaggerated displacement of the atrioventricular canal towards the bulbus cordis (rightward displacement of the mitral valve).


Role of the sympathetic nervous system in supporting cardiac function in essential arterial hypertension.


Echocardiographic studies of genesis of mitral diastolic murmurs.


Haemodynamics of exercise in children with isolated aortic valvular disease.


Left ventricular hemiblock patterns in ventricular pre-excitation.


Abdominal actinomycosis.

Abdominal actinomycosis.


The calcium palmitate gall-stone.

The calcium palmitate gall-stone.


Unabsorbable suture material--a rare cause of recurrent stones in the common bile-duct.


Vein-graft by-pass in axillary and brachial artery occlusions causing claudication.


The influence of electrical stimulation of the leg during surgical operations on the subsequent development of deep-vein thrombosis.


Carcinoma of the ampulla of Vater and duodenum.


Subtotal colectomy and caecoproctostomy.


Pseudocyst of the pancreas.

Pseudocyst of the pancreas.


Renal function and hypertension in primary hyperparathyroidism.


Splenosis. A case report and some considerations on the function of splenotic tissue.


Isotope venography.

Isotope venography.


Intracranial subdural abscess.

Intracranial subdural abscess.


Stercoral perforation of the sigmoid colon.


Observations on acute pancreatitis. A retrospective clinical study.


Fundoplication for hiatus hernia.

Fundoplication for hiatus hernia.


Torsion of the isolated Fallopian tube.

Torsion of the isolated Fallopian tube.


Atherosclerosis and aneurysm formation in a saphenous vein-graft.


Adult hypertrophic pyloric stenosis.

Adult hypertrophic pyloric stenosis.


Starch and intraperitoneal adhesion formation.


Experimental investigation of the use of cyano-acrylate adhesive to prevent biliary leakage in percutaneous transhepatic cholangiography.


Kocher's perampullary approach for common bile-duct calculi.


Traumatic rupture of the ileum.

Traumatic rupture of the ileum.


Embryonic rhabdomyosarcoma of the urogenital tract.


The diagnosis and prophylaxis of pulmonary complications of surgical operation.


Malnutrition and malabsorption in Crohn's disease with reference to the effect of surgery.


Partial hepatectomy using a carbon-dioxide laser.


The effect of increased oxygen in acute limb ischaemia.


Pneumomediastinum and subcutaneous emphysema after perforation of the duodenum during gastroscopy.


An unusual case of swallowed dental plate and perforation of the sigmoid colon.


Adenocarcinoma developing in an ileocystoplasty.