Surgical anatomy of the pubovesical (puboprostatic) ligaments.


A new concept of bilharzial bladder neck obstruction: the triple mechanism.


Some considerations in the design of a suitable topical chemotherapeutic agent to treat bladder cancer.


Preoperative irradiation in the surgical treatment of transitional cell cancer of the bladder: preliminary report based on 12 years of experience.


The value of pelvic lymphadenectomy in the surgical treatment of bladder cancer.


Congenital urethral perineal fistulas.

Congenital urethral perineal fistulas.


Leiomyoma of the female urethra.

Leiomyoma of the female urethra.


Concomitant bilateral epidermoid cysts of the testes.


Interstitial cell tumor of the testis in adults: two case reports.


Genital cysts of the male pelvis: case report of Müllerian and ejaculatory duct cysts in the same patient.


A method of measuring blood loss during transurethral prostatic surgery.


The treatment of stage C prostatic cancer with special reference to combined surgical and radiation therapy.


Echinococcal disease of the pelvis: urologic complication, diagnosis and treatment.


Demonstration of 2 unusually large pelvic lymphocysts by lymphangiography.


Arteriography in pelvic fractures with massive hemorrhage.


The transpubic approach to the lower urinary tract.


Unusual configuration of crossed fused renal ectopia: case report.


Renal angiomyolipoma in an adolescent: a case report.


The deleterious effect of constipation upon the reimplanted ureter.


Complete duplication of bladder and urethra: a case report with review of the literature.


Congenital torsion of the penis.

Congenital torsion of the penis.


Congenital urethral polyp in the infant: case report and review of the literature.


Surgery and leprosy.

Surgery and leprosy.


The management of tarsal bone disintegration.


The solar bath.

The solar bath.


Mis-reinnervation in leprous neuritis affecting the facial nerve.


The health-illness profile: an essential component of the ambulatory medical record.


Ambulatory medical care data: analysis of utilization data.


The community hospital: ambulatory services, statistics, and medical care record data.


Ambulatory medical care data: methods for classifying symptoms, complaints, and conditions.


Methods of classifying disability and severity of illness in ambulatory care patients.


Implications of computer science for developing ambulatory medical record systems.


The design of reporting systems for health care programs.


Ambulatory medical care data. Report of the Conference on Ambulatory Medical care records: introduction.


The E Book system for record-keeping in general practice.


Ambulatory medical care data. Report of the Conference on Ambulatory Medical Care Records: review of the conference proceedings.


The national ambulatory medical care survey.


Information requirements for management of new health care organizations.


The Denver areawide health data management system.


Ambulatory medical care data: Milwaukee Model Cities survey of outpatient utilization.


Ambulatory medical care data: information for patient care in office-based practice.


The choice and dosage of narcotic analgesics.


Vegetarian diets.

Vegetarian diets.


Evaualtion of the performance of ambulatory care systems: research requirements and opportunities.


Ambulatory medical care data: information for planning and evaluating the education of health manpower.


Ambulatory medical care data: information for self-evaluation of patient care and feedback to physicians.


Ambulatory medical care data: information for epidemiologic and health services research.


Record systems for hospital outpatient clinics.


Information for developing national statistics on ambulatory medical care.


Terminology and coding of medical care data.


Application of oxine in the polarographic analysis of organometallic compounds. Microdetermination of cadmium, magnesium, zinc, manganese, and cobalt.


Anticatalytic microdetermination of mercury using cerium-arsenite reaction.


Quantitative analysis of 3-indoleacetic acid and serotonin by in situ fluorescence on thin-layer chromatograms.


Determination of trace fluorine in biological materials by photonuclear activation analysis.


Studies on the intravenous fat tolerance test in patients with compensated liver cirrhosis and chronic aggressive hepatitis.


The isolation of amoeba RNA of low protein content in high yields.


Serum copper studies in the lymphomas and acute leukemias.


Management of malignant, premalignant, and minimally invasive ovarian lesions.


Transplacental induction of vaginal cancer by synthetic estrogens. Evidence that maternal use of synthetic estrogens may induce vaginal cancer in daughters born of these pregnancies is reviewed.  During the period of January 1950-November 1971, 7 adenocarcinomas of the vagina were reported to the New York State Cancer Registry.  The women were under the age of 30.  These patients were studied in detail for history of drug use by their mothers during pregnancy.  Record of controls were searched for history of stilbestrol use.  The patients were born in 1951, 1952, or 1953, and were 15-19 years old at the time of diagnosis.  Place of birth varied widely.  Synthetic estrogen therapy was definitely given to mothers of 6 patients.  Mothers of 5 patients received stilbestrol and the mother of 1 patient received dienestrol.  The seventh mother possibly received stilbestrol.  Obstetricians used the therapy to prevent threatened abortion.  The method and amount of synthetic estrogen given is described.  Histologically, all tumors resembled those described in previous study, containing the characteristic clear cells and "hobnail: cells.  3 patients died of advanced disease, although diagnosis was made within 2 months of known onset of symptoms.  Although a 21-year period was studied, 5 of the 7 cases were detected in the past 2 years.  The authors believe it is probable that an increasing number will be seen in the next several years or more.  The possible carcinogenic effects of stilbestrol have been reported in human adults.  Animal studies have also demonstrated such effects.  The selected nature of the study discussed prohibited the authors from drawing a definite negative conclusion concerning maternal estrogen therapy and cancer of sites other than vagina.


Ovarian tumors associated with the Peutz-Jeghers syndrome.


Ovarian teratomata.

Ovarian teratomata.


The challenge of the biologic aspects of cancer of the breast.


Melanotic ovarian neoplasms.

Melanotic ovarian neoplasms.


Metastatic cancer of unknown primary site.


The second-look operation in ovarian carcinoma.


The role of radiation therapy (including isotopes) in the treatment of cancer of the ovary (results of 614 patients treated at Memorial Hospital, New York, N.Y.).


Factors influencing the prognosis of ovarian cystadenocarcinomas.


Lymph nodes, lymphatics, and the spread of cancer.


The treatment of ovarian cancer.

The treatment of ovarian cancer.


Primary carcinoma of the fallopian tube.


Visualization of malignant tumors by  75 Se-selenomethionine scintigraphy.


A comparison of diagnostic accuracy of liver scans, liver function tests, and liver biopsy.


Diagnostic accuracy in cancer as determined by post mortem examination.


A combination and sequential chemotherapy approach to advanced mammary carcinoma.


Affective and suicidal symptoms in epileptic prisoners.


Kennedy-Galton Centre, Harperbury Hospital.


Studies on the activity of the pituitary-gonadal axis in the XYY syndrome.


Barbiturate tolerance and psychological functioning in elderly depressed patients.


Catecholamine-containing neurones and electrical self-stimulation. 2. A theoretical interpretation and some psychiatric implications.


Plasma cortisol-binding capacity in mental illness.


A self-rating scale of distress.

A self-rating scale of distress.


A bold experiment at Bromley.

A bold experiment at Bromley.


Life-events and psychiatric disorders. 1. Some methodological issues.


Epilepsy: education and enigma.

Epilepsy: education and enigma.


Setting course for adventure.

Setting course for adventure.


Forging the school-work link.

Forging the school-work link.


What about the integrated child?

What about the integrated child?


Sex education and mental handicap.

Sex education and mental handicap.


Teacher training by television.

Teacher training by television.


The type of research the profession needs.


The type of graduate the profession needs.


Actinobacillus equuli infection in a litter of pigs and a review of previous reports on similar infections.


Management factors influencing practice performance.


Anatomical and behavioral correlates of visual acuity in the Great Horned Owl.


Scotopic spectral sensitivity in a teleost fish (Scardinius erytheophthalamus) adapted to different daylengths.


The relation of flash intensity and background illumination to the photic evoked potential in the pigeon's optic tectum.


Human receptive field characteristics: probe analysis of stabilized images.


Light adaptation for visual pattern recognition in flies.


Dynamic properties of vision. 3. Twin flashes, single flashes and flickerfusion.


Spatial summation in color-receptive pathways.


Origin of the stochastic nature of ganglion cell activity in isolated goldfish retina.


A theory of the Müller-Lyer illusion.

A theory of the Müller-Lyer illusion.


The masking of apparent motion in random-dot patterns.


In search of the neural channel which codes real light and equivalent backgrounds.


Brightness and equivalent intensity of intrinsic light.


Grating resolution and refraction in the cat estimated from evoked cerebral potentials.


Two dimensional eye movement recording using a photo-electric matrix method.


The focal length of the fish eye lens and visual acuity.


The effects of electrical stimulation of the eye upon increment threshold for square-wave gratings.


A simple method for projecting patterns on the cat's retina under direct visual control.


Dependence of fast components of the electroretinogram of the isolated rat retina on the ionic environment.


Modified rhodopsin in the pigment epithelium?


Monocular and binocular aspects of apparent movement.


Observing accommodation in the cat.

Observing accommodation in the cat.


Effect of urea on the early receptor potential.


On the approximation of the optical modulation transfer function (MTF) by analytical functions.


Central component of fusional response: the effect of stimulus parameters.


Visual evoked cortical potentials during pressure-blinding.


The role of colour perception and "pattern" recognition in stereopsis.


Anomalous dispersion in visual photoreceptors.


Saccadic suppression in the presence of structured background.


Doubts about scotopic interactions in stabilized vision.


Exercise-induced ventricular arrhythmias in patients with coronary artery disease. Their relation to angiographic findings.


Premature ventricular complexes induced by stress testing. Their frequency and response to physical conditioning.


Electrocardiographic atrial complex and acute atrial myocardial infarction.


Should coronary arteriography be performed routinely before valve replacement?


Deleterious effects of increased heart rate on infarct size in the conscious dog.


Compensatory mechanisms during graded myocardial ischemia.


Regional contraction patterns in the normal and ischemic left ventricle in man.


Ultrasonically guided pericardiocentesis.


Repair of mitral regurgitation. An 11 year experience.


Tachycardia-bradycardia syndrome (so-called "sick sinus syndrome"). Pathology, mechanisms and treatment.


Partial anomalous pulmonary venous connection and drainage.


Congenital right-sided pericardial defect with herniation of part of the lung into the pericardial cavity.


Recurrent ventricular tachycardia in association with ventricular aneurysm.


Fourth sound gallop or split first sound?


Intrauterine growth retardation in familial dysautonomia.


Oxandrolone for growth promotion in Turner syndrome.


A family with blepharo-naso-facial malformations.


How many more treatment trials in otitis media?


Picture of the month. Sickle cell anemia.


Massive intracranial hemorrhage in sickle-cell anemia.


Probable monosomy-21 and partial trisomy.


Oculoauricular vertebral dysplasia. Its association with sensorineural deafness and other abnormalities.


Familial renal-retinal dystrophy.

Familial renal-retinal dystrophy.


Congenital bilateral pleural effusions. A cause for respiratory failure in the newborn.


Neonatal infection with Streptomyces pelletieri.


The health of American Indian children.

The health of American Indian children.


Maternal aminopterin ingestion.

Maternal aminopterin ingestion.


Use of morphine in respiratory failure.

Use of morphine in respiratory failure.


Abnormal serum and muscle creatine phosphokinase (CPK) isoenzyme pattern in a family with malignant hyperthermia.


Publications: progress or pollution.

Publications: progress or pollution.


The fluorimetric determination of phosphate with thiamine.


Electrochemistry of cobalt-porphyrin complexes in aqueous solution.


Chemical methods of male contraception.

Chemical methods of male contraception.


The determination of manganese in urine by atomic absorption spectrometry.


Investigation of the urinary metabolite of the catecholamines in symptomatic and asymptomatic asthma patients.


Test for aspirin intolerance (hypersensitivity) and adrenergic stimulators.


Atopic skin test reevaluated. II. Variability in results of skin testing done in ocutplicate.


Systemic fungal infection complications in asthmatic patients treated with steroids.


Comparison of neutralizing activity in nasal secretion and serum of ferrets in response to infection with influenza A viruses.


Virus particles and antigens in natural orf.


Elimination of non-specific reaction in latex agglutination test for the detection of hepatitis-associated antigen.


Different histopathological response to arenovirus infection in thymectomized mice.


Studies on influenza virus hemagglutination inhibition by anti-host serum.


Basic dyes as inducers of interferon-like activity in mice.


Nocardia-like mutants of a soil coryneform bacterium.


Changes in phospholipid composition of Thiobacillus neapolitanus during growth.


Induction of interferon in L cells by polyinosinic-polycytidylic acid in the presence of cationic compounds.


Electromyographic studies in myotonia congenita.


Decubitus ulcers in swine: light and electron microscopy study of pathogenesis.


Progression of pelvic tilt in adolescent boys from elementary through high school.


Behavior modification in a community hospital rehabilitation unit.


Diagnostic specificity of motor and sensory nerve conduction variables in the carpal tunnel syndrome.


Parkinsonism: facilitation of motion by sensory stimulation.


Auditory comprehension in aphasic adults: improvement through training.


Effects of immobilization in the human forearm.


Fluidic power and control for hand orthosis and prosthesis.


Liquid crystal tape: its use in the evaluation of vascular diseases.


[Effect of 6-ethoxy 2,2,4-trimethyl-1,2-dihydroquinoline (ethoxyquin) on carbon tetrachloride metabolism in the rat].


Allylisopropylacetamide-induced propyria-protective effect of 3,5-dimethylisooxazole.


Piracetam (2-pyrrolidinone acetamide) induced modifications of the brain polyribosome pattern in ageing rats.


Mechanism of "biochemical shock". 3. Comparative study of biochemical effects induced by a radioprotective and a non-radioprotective compound of isomer structure.


Liberation of cyanide from succinonitrile.


Effects of derivatives of indole carboxylic acids on carbohydrate metabolism of the rat.


Cell membrane modifications in rabbit isolated hepatocytes following a chronic amitryptiline treatment.


Partial purification of L-glutamine:D-fructose 6-phosphate aminotransferase from zoospores of Blastocladiella emersonii.


Kinetic analysis for solid-supported enzymes.


Purification of lysosomal prolycarboxypeptidase angiotensinase C.


Benzoylamidoacetonitrile as an inhibitor of papain.


Familial syndrome of midsystolic click and late systolic murmur.


Phonocardiogram and apex cardiogram in systolic click--late systolic murmur syndrome.


Temporal sequence of right and left atrial contractions during spontaneous sinus rhythm and paced left atrial rhythm.


QT interval in right and left bundle-branch block.


Double inlet right ventricle. Two pathological specimens with comments on embryology.


Catheterization of the pulmonary artery in transposition of the great arteries using a Swan-Ganz flow-directed catheter.


Pulmonary valvular dysplasia. A cardiofacial syndrome.


Effect of lignocaine on conducting system of human heart.


Standardized diagram for rapid tabulation of coronary arteriograms.


Constraints on consultants.

Constraints on consultants.


Tuberculous peritonitis and laparotomy.

Tuberculous peritonitis and laparotomy.


Ventricular tachycardia in a patient with toxoplasmosis.


Teachers and patients.

Teachers and patients.


Sudden whitening of hair.

Sudden whitening of hair.


Current radiotherapy.

Current radiotherapy.


Postoperative empyema and survival in lung cancer.


Latent morbidity after abortion.

Latent morbidity after abortion. A recent paper by M. Wynn and A. Wynn warns against long-term effects of abortion, designated "latent morbidity." Present practice of a short follow-up period is said to be inadequate. After several years the morbidity rate may be 30%.  Increases in subsequent perinatal deaths, premature births, ectopic pregnancies, pelvic inflammation, menstrual disorders, and subsequent sterility are said to follow. A statistically significant increase in premature labors, more frequent  postpartum hemorrhage, more spontaneous abortions, rhesus isoimmunization, and even congenital malformations are claimed to result. Since 1970, the number of illegitimate births in Britain are said to have only slightly decreased. Abortion is  referred to as being used to replace a contraceptive method. The effect of human behavior is questioned. It may be argued that the case is overstated but the supporters of abortion need to reply.


Use of 4 per cent chlorhexidine detergent solution (Hibiscrub) and other methods of skin disinfection. In a comparison of three antiseptic detergent preparations for hand washing, Hibiscrub, a 4% chlorhexidine detergent solution, caused a significantly greater estimated immediate reduction of skin flora (86.7% +/- 3.0) than was obtained with Dermofax, a 0.75% chlorhexidine detergent solution (55.5% +/- 5.1), or with Disadine scrub, a povidone iodine detergent preparation (68% +/- 6.8). After six applications the mean estimated reductions of skin flora were 99.2% +/- 0.2 for Hibiscrub, 97.7% +/- 0.7 for povidone iodine, and 91.8% +/- 1.6 for Dermofax.After a series of hand washings with Hibiscrub, as with a hexachlorophane detergent preparation, a further large reduction of skin flora, shown by bacterial counts of hand sampling, was obtained by a second phase of disinfection consisting of two minutes' application on gauze swabs of 0.5% chlorhexidine digluconate in 70% ethanol; a further wash with Hibiscrub, in place of alcoholic chlorhexidine, for the second phase of disinfection caused an increase rather than a reduction in the yield of bacteria on skin sampling. Unlike this "two-phase" disinfection, the application for 30 minutes of compresses soaked in 10% aqueous povidone iodine or in 0.5% aqueous chlorhexidine digluconate did not cause a greater reduction in skin flora than that obtained by the conventional two minutes' application on gauze of 0.5% chlorhexidine in 70% ethanol.Chlorocresol (0.3%) liquid soap (the base used for Ster-Zac liquid hexachlorophane soap) caused a mean reduction of skin flora when used for hand washing of 29% after one application and 72% after six applications spread over two days. This formulation, though less active and more variable as a detergent skin antiseptic than chlorhexidine, hexachlorophane, or povidone iodine detergent preparations, is an inexpensive disinfectant soap which could be useful in catering establishments. Alcoholic cetrimide applied as for disinfection of an operation site caused a reduction of skin flora greater than that shown by aqueous cetrimide but comparable to that shown by 70% ethyl alcohol in previous experiments.


Autoregulation of brain circulation in severe arterial hypertension. Cerebral blood flow was studied by the arteriovenous oxygen difference method in patients with severe hypertension and in normotensive controls. The blood pressure was lowered to study the lower limit of autoregulation (the pressure below which cerebral blood flow decreases) and the pressure limit of brain hypoxia. Both limits were shifted upwards in the hypertensive patients, probably as a consequence of hypertrophy of the arteriolar walls. These findings have practical implications for antihypertensive therapy.When the blood pressure was raised some patients showed an upper limit of autoregulation beyond which an increase of cerebral blood flow above the resting value was seen without clinical symptoms. No evidence of vasospasm was found in any patient at high blood pressure. These observations may be of importance for the understanding of the pathogenesis of hypertensive encephalopathy.


Postoperative deep vein thrombosis in Sudanese patients. The incidence of postoperative deep vein thrombosis diagnosed by radioisotope scanning in 100 Sudanese patients aged 40 or over was 12%. This compares with an incidence of nearly 30% in 542 patients reported from British hospitals using the same diagnostic technique. The reason for the difference is obscure and needs further investigation.


Deep vein thrombosis in a Queensland hospital. Investigation in the postoperative period of 75 patients by means of the radioiodinated fibrinogen uptake method, by the use of the Doppler ultrasonic flow detector, and by clinical assessment revealed an incidence of deep vein thrombosis of only 12%. This is distinctly lower than has been reported by other investigators using the same techniques both in Australia and elsewhere. It appears from this study and associated work that the Doppler ultrasonic technique is sufficiently accurate to be of value in the clinical diagnosis of significant deep vein thrombosis.


Androgen responses during physical exercise. The serum androgen response to physical exercise was studied in highly trained athletes and in normal male medical students. Serum androgens rose in response to maximal exercise and the rise was independent of serum luteinizing hormone. No response was obtained with submaximal exercise.


Concentration of wear products in hair, blood, and urine after total hip replacement. Raised levels of cobalt and chromium are found in the blood and urine of patients with metallic total hip replacements. When one of the hip components is made of polyethylene much less metal seems to be released from the joint. The long-term effects of the accumulation of chromium in the body need to be studied further.


Mumps pancreatitis without parotitis.

Mumps pancreatitis without parotitis.


Patient delay before treatment of myocardial infarction. Fifty patients in hospital with a definite recent myocardial infarction were interviewed, particular attention being paid to the delay before medical attention was sought. No evidence was found to associate delay with age, sex, or social class. The delay was longer outside normal working hours, and in some patients this seemed to be due to inhibition from disturbing their general practitioner. It is suggested that doctors should ensure that patients at high risk of sustaining a myocardial infarction should not be inhibited from seeking attention quickly if the need arises.


Drug taking among medical students at Glasgow university. A survey of medical students was conducted at Glasgow University during two successive academic sessions. In 1971, out of 786 students matriculating in the first to fourth years, 749 present at lectures (95.3%) returned properly completed questionnaires. These showed that 100 (13%) had at one time or another taken drugs and that 27 (3.6%) had continued to do so. In 1972, out of 604 students matriculating in the first, second, and fifth years 487 (80.6%) returned questionnaires indicating that 79 (16%) had taken drugs at least once and that 19 (3.9%) had continued.Marijuana and hashish were by far the most commonly used drugs, the use of "harder" drugs being limited. About half of the students acknowledged the regular use of alcohol, and approximately a fifth were regular tobacco smokers. Those who took drugs were predominantly males who tended to smoke and drink more than other students. They also came from homes where the parents no longer lived together and tended to live away from home more than the other students. Exposure to drugs increased between 1971 and 1972, but the number accepting drugs did not. Appraisal of this problem is needed, since though still small it has the potential for rapid growth.


Treatment of malignant melanoma.

Treatment of malignant melanoma.


Central-core disease and malignant hyperpyrexia.


Cost of drugs.

Cost of drugs.


Sarcoid heart disease.

Sarcoid heart disease.


Cutaneous sarcoidosis in venepuncture sites.


Gastric decompression after abdominal surgery.


Working of the Mental Health Act.

Working of the Mental Health Act.


Myocardial infarction and pulmonary thromboembolism.


Fractured Lippes loop and pregnancy.

Fractured Lippes loop and pregnancy.


Pathogenesis of obesity.

Pathogenesis of obesity.


Fluoride and osteoporosis.

Fluoride and osteoporosis.


Potentiation of neuroleptics by catecholamine inhibitors.


Vitamins in illness.

Vitamins in illness.


Tubal sterilization and its reversal.

Tubal sterilization and its reversal.


Free contraceptives.

Free contraceptives.


Rigid footwear.

Rigid footwear.


Nitrazepam and the elderly.

Nitrazepam and the elderly.


Soaking beds.

Soaking beds.


Treatment of dextropropoxyphene poisoning.


Termination of hospital contract.

Termination of hospital contract.


Primary excess and deficiency or renin.

Primary excess and deficiency or renin.


Pruritus vulvae.

Pruritus vulvae.


New ideas on vitamin D.

New ideas on vitamin D.


Paradoxical embolism.

Paradoxical embolism.


Renal cysts and red hair.

Renal cysts and red hair.


Deaths in England and Wales.

Deaths in England and Wales.


Secondary hyperparathyroidism in patients with endemic skeletal fluorosis. Investigation of 20 patients with skeletal fluorosis showed that five had clear evidence of secondary hyperparathyroidism. The hyperactivity of the parathyroid glands in skeletal fluorosis in the presence of decreased solubility of the bone mineral (fluoroapatite) strongly suggests that it is a compensatory attempt to maintain a normal extracellular ionized calcium equilibrium. Further study of the parathyroid glands and of bone lesions in skeletal fluorosis is in progress.


Intravascular coagulation complicating influenza A virus infection.


Vitamin B 12  malabsorption after cobalt teletherapy for carcinoma of the bladder. After cobalt teletherapy for carcinoma of the bladder, eight out of 14 consecutively admitted patients were shown to have malabsorption of vitamin B(12), though none had developed a megaloblastic anaemia. Despite lack of symptoms this group of patients is at risk after radiotherapy.


Active chronic hepatitis after chlorpromazine ingestion.


Cubital tunnel external compression syndrome. External compression of the cubital tunnel comprises the acute and subacute forms of ulnar nerve compression at the elbow. Subacute compression is often seen in hospital practice and sometimes results in partial crippling of the hand. Prognosis for complete recovery is poor. Avoidance of a position of the elbow which predisposes to external compression of the ulnar nerve within the cubital tunnel is advised when a patient is on the operating table, in bed or in an armchair. Prolonged severe elbow flexion in these circumstances should also be avoided. The patient suffering from the syndrome should be instructed to avoid further pressure so that worsening of the palsy is minimized. A compressed nerve is likely to be more sensitive than a normal nerve to ischaemia produced by subsequent pressure. Surgical treatment is sometimes indicated at least to halt progression of the palsy.


Cryodestruction of haemorrhoids.

Cryodestruction of haemorrhoids. Thirty-seven cases of second and third degree haemorrhoids have been treated by cryosurgery. Although the number of cases treated is small and the follow-up is short, we are greatly encouraged by the early excellent results. It is a simple and effective procedure with minimal complications, and it is especially recommended for those patients who are medically unfit for general anaesthesia. The rapidity of this procedure combined with the painless operative and postoperative course enables the patient to leave hospital the next day. More cases with long-term follow-up are needed before adequate evaluation of this form of treatment can be made.


Dysentery including amoebiasis.

Dysentery including amoebiasis.


Tuberculous peritonitis and laparotomy.

Tuberculous peritonitis and laparotomy.


Thiocyantate metabolism in human vitamin B 12  deficiency.


Children of anaesthetists.

Children of anaesthetists.


Contact sensitivity to toothpaste.

Contact sensitivity to toothpaste.


Serum alkaline phosphatase and rickets in urban schoolchildren.


Congenital hemihypertrophy.

Congenital hemihypertrophy.


Lignocaine in donor blood.

Lignocaine in donor blood.


Diseases of Western civilization.

Diseases of Western civilization.


Day hospitals and day centres.

Day hospitals and day centres.


Oil myelography.

Oil myelography.


Postherpetic neuralgia.

Postherpetic neuralgia.


Efficacy of whooping-cough vaccines.

Efficacy of whooping-cough vaccines.


Cranial nerve palsy in tetanus.

Cranial nerve palsy in tetanus.


Gateshead tuberculin survey.

Gateshead tuberculin survey.


Loin percussion in acute pyelonephritis.


Pregnancy after hysterotomy.

Pregnancy after hysterotomy. The conclusion reached by Drs. W.M. Clow and A.C. Crompton (February 10, p. 321) that there is a substantial risk of uterine rupture in pregnancy after hysterotomy is reinforced by a case recently under my care.  The patient, an unmarried 16-year-old, had had her 1st pregnancy terminated by abdominal hysterotomy at another hospital when she was 14 years of age.  She was admitted to this hospital at 38 weeks' gestation (before the onset of labor) with signs and symptoms suggestive of intraabdominal hemorrhage.  At laparotomy the upper end of the "classical" hysterotomy scar had ruptured completely and a portion of the underlying placenta was protruding through it. There was about 2 1/2 l of fluid and clotted blood in the peritoneal cavity.  Caesarian supravaginal hysterectomy was performed and both mother and child survived, but the former required blood transfusions totaling 3 l. While fully agreeing with the authors' suggestion that hysterotomy should in general be eschewed unless sterilization is also performed, there may be circumstances in which hysterotomy is urgently indicated but sterilization is undesirable.  In such cases, if the operation is performed after the 18th-20th week, the lower uterine segment is often sufficiently developed to permit evacuation through a transverse incision at this level.  It would seem likely by analogy with classical and lower segment Casarean section incisions that the risk of uterine rupture in a subsequent pregnancy will be considerably reduced by  this technique, which I now use whenever possible instead of the vertical upper segment incision usually employed for hysterotomy.


Record damages in U.S.A.

Record damages in U.S.A.


Seat belts.

Seat belts.


Tumoral calcinosis in Britain.

Tumoral calcinosis in Britain.


Toxic effects of local anaesthetics on human respiratory epithelium.


Acute and chronic toxicity of anaesthetics. Introduction.


Anaesthesia and the liver: history and epidemiology.


Cytotoxic effects of halogenated anaesthetics on cultured human liver and embryonic kidney cells.


Hazards of vaccination in pregnancy.

Hazards of vaccination in pregnancy.


Blood serum fluoride levels with methoxyflurane anaesthesia.


Influenza vaccination by aerosol nasal spray.


Acid-catalyzed addition of alcohols and thiols to bilirubin.


The incorporation of  45 Ca into the egg of the medaka, Oryzias latipes.


Structural characterization of immunoglobulins contained in polyacrylamide gels.


Intestinal monosaccharide transport in experimental protein deprivation.


Changes in the ultrastructure of erythrocyte membrane subjected to UV-irradiation in vitro.


Basal forebrain heating and osmotic reactivity of the thirst mechanism in dogs.


Membrane potential measurement in mouse salivary gland cells.


Biphasic secretory potentials in cat and rabbit submaxillary glands.


Reactivity of myoglobin in heart, striated muscle and uterus in a methaemoglobinaemia.


The effect of asphyxia and re-oxygenation on bilateral dorsal root potentials produced by stimulation of the cutaneous afferents.


The effect of the change of position on the nonesterified fatty acids.


Proteins and atherosclerosis.

Proteins and atherosclerosis.


Synthesis of (4-leucine)-arginine-vasotocin, a natriuretic analogue of arginine-vasotocin.


The natriuretic action of (4-leucine)-arginine-vasotocin.


New observations in the metabolism of morphine. The formation of codeine from morphine in man.


Some pharmacological properties of (4-leucine)-arginine-vasotocin.


Blood citric acid cycle and individual response to morphine analgesia in rats.


Interaction of chloramphenicol and   1 -tetrahydrocannabinol in barbital-anesthetized mice.


Spontaneous release and during metrazol convulsions of 5-hydroxytryptamine in some brain regions of conscious cat.


Prevention of 7,12-dimethylbenz( )anthracene-induced adrenal necrosis by cyproterone acetate.


Induced dominant lethals in female mice: effects of triaziquone and phenylbutazone.


Influence of vitamin A on experimental atherosclerosis in rabbits.


A depolymerizing effect of the luteinizing hormone and follicle stimulating hormone on the neurotubules of the hypothalamus-hypophysial tract in the rat.


The teratogenic response of the mouse embryo to 5-iododeoxyuridine.


Effects of placental lesions on foetal growth in rats.


Development of isolated neocortex.

Development of isolated neocortex.


An attempt to immunize the blue crab, Callinectes sapidus, with vertebrate red blood cells.


Artero-venous differences in blood platelet clumping by ADP.


Intercellular lacunae: sequestered microenvironments in stimulated leukocyte cultures.


Isozymes of amine oxidase in human plasma and other tissues.


Phagocytosis of latex particles in vitro: effects of antilymphocyte and antithymocyte serum.


Inhibition of epinephrine-induced glycogen phosphorylase activation by Bordetella pertussis vaccine in rats.


Erythrocyte chimaerism in W-series anaemic mice after allogeneic splenic transplants to the renal cortex.


Brain norepinephrine levels and turnover rates in castrated mice isolated for 13 months.


Basal forebrain heating and ADH release in dogs.


An electron microscope study of the anal organs of Drosophila larvae.


Accumulation of ribonucleoprotein structures in chronically virus-infected cells.


A survey of some cariogenic streptococci for hyaluronidase activity.


Lipid mobility and function in biological membranes.


Experiments on the tumour cells using time-lapse microcinematography.


Antimicrobial compounds. II. Alkylidene, cycloalkylidene and arylidene derivatives of 3-hydrazino--6-chloropyridazine 1-oxide.


Laxative properties of esters of 4,4'-dihydroxydiphenyl-(2-pyridyl)methane.


3,4-0-diacyl derivatives of dopamine.

3,4-0-diacyl derivatives of dopamine.


Serum immunoglobulin levels in workers exposed to benzene, toluene and xylene.


Leukocyte agglutinins in workers exposed to benzene, toluene and xylene.


Pulmonary fibrogenic response of guinea pigs to amosite dust.


Volvulus associated with Meckel's diverticulum in the horse.


Studies of the acute effects of NO 2  on lung function: influence on diffusion, perfusion and ventilation in the lungs.


Tetralogy of fallot in a thoroughbred foal.


Terminal ileitis in lambs.

Terminal ileitis in lambs.


A diagnostic survey of bovine abortion and stillbirth in the Northern Plains States.


Repair of femoral head and neck fractures by interfragmentary compression.


Toxic effects of carbofuran in cattle and sheep.


Demonstration of the hybrid hemoglobin   2  A   A   S .


Role of elongation factors and the effect of aurintricarboxylic acid on the synthesis of polyphenylalanine.


Synthetic template specificity of a deoxyribonucleic acid polymerase from regenerating rat liver.


Anthranilate synthase from Pseudomonas putida. Purification and properties of a two-component enzyme.


The distribution of glutaminase isoenzymes in the various structures of the nephron in normal, acidotic, and alkalotic rat kidney.


Isolation of protein synthesis initiation factors from rabbit liver.


Purification and properties of maleylacetone cis-trans isomerase from vibrio 01.


Glucose transport in isolated brush border membrane from rat small intestine.


The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. The relationship between fatty acid oxidation and esterification in the regulation of ketogenesis.


Partial purification and properties of two forms of deoxyribonucleic acid polymerase from calf thymus.


Leucine aminopeptidase (Bovine lens). Mechanism of activation by Mg 2+  and Mn 2+  of the zinc metalloenzyme, amino acid composition, and sulfhydryl content.


Chemistry and biosynthesis of the poly( -D-glutamyl) capsule in Bacillus licheniformis. I. Properties of the membrane-mediated biosynthetic reaction.


Chemistry and biosynthesis of the poly( -D-glutamyl) capsule in Bacillus licheniformis. II. Characterization and structural properties of the enzymatically synthesized polymer.


Studies on ligand binding to hemoglobins from teleosts and elasmobranchs.


Activation of thyroid membrane adenylate cyclase by purine nucleotides.


Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation.


Calcium and energy requirements for K +  release mediated by the epinephrine  -receptor in rat parotid slices.


Aerobic metabolism of 3,5-diaminohexanoate in a Brevibacterium. Purification of 3,5-diaminohexanoate dehydrogenase and degradation of 3-keto-5-aminohexanoate.


Purification and characterization of glycine N-methyltransferase.


Affinity labeling of aspartate aminotransferase isozymes by bromopyruvate.


Studies on T4-induced nucleases. Isolation and characterization of a manganese-activated T4-induced endonuclease.


Oxidation of 20 -hydroxycholesterol by adrenal cortex mitochondria.


Cancer prognosis. Staging in pulmonary carcinoma.


Growth patterns and diabetes. Control in diabetic children.


Progressive cerebellar dyssynergia. The use of diazepam.


Clinical cardiology. Carotid sinus reflex.


The use of marijuana by medical students.


This perplexing power.

This perplexing power.


Structural and functional role of leucine residues in proteins.


Isopycnic banding of chromatin in chloral hydrate gradients.


Crystal structure analysis of sea lamprey hemoglobin at 2 angstrom resolution.


Studies on the thermal denaturation of nucleohistones.


Preliminary crystallographic data for actinidin, a thiol protease from Actinidia chinensis.


Dose-response studies with concurrent administration of piperazine and sodium nitrite to strain A mice.


Repetitive administration of BCG in prevention and treatment of spontaneous leukemia of AKR mice.


Accumulation of  3 H-estradiol in transplanted interstitial cell tumors in mice.


Augmentation of antitumor antisera activity by lyophilization.


Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors.


A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas.


Cytotoxic agents designed to be selective for liver cancer.


Capillary tube scanning applied to in vitro mouse marrow granulocyte growth.


Transformation of spleen cells three hours after infection in vivo with Friend leukemia virus.


Growth of carcinomas in the region of the cartilage.


Inhibition of DNA synthesis by an extract from human placenta.


Radiotherapy of experimental lung tumors in the presence and absence of a radioprotective drug, S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721).


Malignant transformations of C3H mouse cells in vitro. Development of transplantable ascites tumors from mouse embryo cells treated with 4-nitroquinoline 1-oxide.


Differential effect of immunosuppression on the induction of nervous system and bladder tumors by N-methyl N-nitrosourea.


Paroxysmal nocturnal haemoglobinuria in Kenya.


Pattern of disease and accidents in Nigerian children of school age.


Concepts in hepatic amoebiasis.

Concepts in hepatic amoebiasis.


Further therapeutic studies with low dosage metronidazole in amoebiasis.


Susceptibility of Biomphalaria alexandrina to infection with Schistosoma mansoni in Egypt.


Activation of long chain fatty acids by subcellular fractions of rat liver. II. Effect of ethylenic bond position on acyl-CoA formation of trans-octadecenoates.


Activation of long chain fatty acids by subcellular fractions of rat liver. I. Activation of trans-unsaturated acids.


Activation of long chain fatty acids by subcellular fractions of rat liver. 3. Effect of ethylenic bond position on acyl-CoA formation of cis-octadecenoates.


Enhancement of liver microsomal acyl CoA-lysophospholipid acyltransferase activity in pyridoxine-deficient rats.


Free fatty acid metabolism during stress: exercise, acute cold exposure, and anaphylactic shock.


Quantification of lowered cholesterol oxidation in guinea pigs with latent vitamin C deficiency.


Hepatic galactosylceramide in globoid cell leukodystrophy (Krabbe's disease).


In vivo incorporation of  3 H arachidonic acid and  14 C linoleic acid into liver lipids from essential fatty acid-deficient rats.


Cholestanol and plant sterols in pigeon skin.


Colorimetric determination of pyrazole in blood.


Identification of the plant source of the Chinese crude drug "Dan-zhu-ye" using the low-temperature plasma ashing technique.


Detection of organo-phosphorus pesticide residues in autopsy tissues by thin-layer chromatography.


Heterokaryosis in Microsporum gypseum.

Heterokaryosis in Microsporum gypseum.


Frozen prepared microbiological culture media.


Isolation of Basidiobolus meristosporus from natural sources.


Scanning-beam electron microscopy of the conidia of the brown and albino filamentous varieties of Histoplasma capsulatum.


Analysis of induced mutants in Aspergillus niger.


Fat synthesis from supplemented beet molasses by Penicillium soppi Zaleski in still and shaken cultures.


Oral contraception and increased risk of cerebral ischemia or thrombosis.


The health of pilots, and others--G.M.C. inquiry--strange times.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-1973.


Oral contraceptives and stroke.

Oral contraceptives and stroke.


Does transfer factor act specifically or as an immunologic adjuvant?


Cleaner air.

Cleaner air.


Occlusive vascular disease in psoriatic patients.


Hematologic screening tests.

Hematologic screening tests.


Factor VIII preparations.

Factor VIII preparations.


Electroreceptors in brachiopterygii and dipnoi.


Electron microscopy of low-density plasmalipoproteins in patients with type IIa hyperlipoproteinemia.


Diet and coronary heart disease.

Diet and coronary heart disease.


Nutrition labeling.

Nutrition labeling.


Neurochemical studies on characterized neurons.


The rehabilitation of the juvenile delinquent.


Human needs--rehabilitation's next thrust.


Leaderless groups. A tape cassette technic for vocational education.


Piroplasmose canine: polymorphisme clinique.


Orthogonal microvillus pattern in the eighth rhabdomere of the rock crab Grapsus.


Ultrastructural observations on membranous structures in developing mouse oocytes.


The ultrastructure of the pars distalis of the hypophysis in males of Triturus cristatus carnifex Laur., treated with the antiandrogen cyproterone acetate.


Electron microscopy of dental enamel: analysis of crystal lattice images.


Trimethoprim in veterinary medicine.

Trimethoprim in veterinary medicine.


Growth and the problem of the local control mechanism.


Ultrastructure of germ cells and Sertoli cells in the postnatal rabbit testis.


The vascular anatomy of the liver of the monitor lizard (Genus varanus).


Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer's patches. An electron microscopic study.


An in vivo and in vitro autoradiographic investigation of growth in synchondrosal cartilage.


Heart development in the Mexican salamander, Ambystoma Mexicanum. II. Ultrastructure.


Localization of thiamine pyrophosphatase in synaptic vesicles.


Wolman's disease: report of two new cases, with a review of the literature.


Adenomatous polyp with submucosal cysts.


Thyroid and parathyroid glands in the vaginal wall: report of a case.


Multifocal pulmonary lesions of possible decidual origin (so-called pulmonary deciduosis): report of a case.


Tissue mercury levels in the mercury-induced nephrotic syndrome.


Glucose ontent in cerebrospinal fluid: a comparison with glucose levels in serum as determined by copper reduction and hexokinase methods.


Serum triiodothyronine measurements by the Sterling method: a critical evaluation.


Profiles of alkaline phosphatase isoenzymes in serum using cellulose acetate electrophoresis and organ-specific inhibitors.


An evaluation of "kits" for determining urea nitrogen.


Protothecosis of the olecranon bursa caused by achloric algae.


Osteomyelitis caused by Mycobacterium fortuitum: report of a case.


Comparison of activated partial thromboplastin reagents.


Comparison of various activated partial thromboplastin reagents in the laboratory control of heparin therapy.


Disease, cure, and death: epidemiologic and clinical parameters for chronic diseases illustrated by a model--tuberculosis.


Urolithiasis and coronary heart disease: a note on association.


The statistical analysis of the results of sampling an environment for a contaminant when most samples contain an undetectable level.


Surveillance of arboviral encephalitis in the United States, 1955-1971.


Experiences with cefazolin: a new cephalosporin antibiotic.


Kinetics of cephaloridine in experimental wounds.


Experimental coccicidioidal meningitis in rabbits with a procedure for cerebrospinal fluid sampling. Evaluation of the lactic dehydrogenase isoenzymes and coccidioidin latex agglutination results.


Tetracycline inequivalence: the importance of 96-hour testing.


Retinal and cerebral microembolization of talc in a drug abuser.


Hypernatremia with myoglobinuria.

Hypernatremia with myoglobinuria.


Change in homosexual orientation.

Change in homosexual orientation.


The telephone in outpatient psychotherapy.


Requiem for the clinician.

Requiem for the clinician.


Childhood status and adult schizophrenia.


Psychosynthesis and the new biology of dreams and psychotherapy.


Patients with acting-out character disorders.


Subjective culture and psychotherapy.

Subjective culture and psychotherapy.


Treatment of a clergyman: anxiety neurosis in a celibate.


Literature as a therapeutic tool. A review of the literature on bibliotherapy.


Sibling position in India. Psychiatric and nonpsychiatric patients.


Success phobia and retarded ejaculation.


Universality, a therapeutic concept.

Universality, a therapeutic concept.


Kindness in psychotherapy: ambiguities and contradictions.


Incidence and causes of failures to control by irradiation the primary lesions in squamous cell carcinomas of the anterior two-thirds of the tongue and floor of mouth.


Carcinoma of the tonsil and nasopharynx. A 20 year end results report.


Laryngeal carcinoma: correlation of roentgenography and histopathology. A study based on whole organ, serially sectioned laryngeal carcinoma specimens.


Radiation therapy in early carcinoma of the vocal cords. A change in fractionation.


Carcinoma of the larynx. Results of radiation therapy in 213 patients.


Permanent implants in the management of head and neck cancer by radiotherapy.


Long time studies of advanced cancer of the ear treated with electrosurgery plus radiation.


Comparative analysis of two regimens of split course radiation in carcinoma of the lung.


Clinical decisions in the management of stage I endometrial carcinoma.


Choriocarcinoma. Aspects of the clinical pathology.


Pre-estrogen irradiation of the breast to prevent gynecomastia.


Seminoma of the testis.

Seminoma of the testis.


Xeroradiography: image content and comparison with film roentgenograms.


Value of mammography in reduction of mortality from breast cancer in mass screening.


A simplified and reliable cannulation technique for lymphography.


More on the r and c units and some other related units.


The New England Surgical Society and the New England surgeon. Responsibilities and opportunities.


Operative treatment of chronic recurrent pancreatitis.


Exploratory laparotomy and splenectomy in Hodgkin's disease.


Gastrojejunocutaneous fistula.

Gastrojejunocutaneous fistula.


Reflux bile gastritis.

Reflux bile gastritis.


Major abdominal trauma in 1971. A study of Connecticut by the Connecticut Society of American Board Surgeons and the Yale Trauma Program.


Colorectal carcinoma at the Lahey Clinic, 1962-1966.


Surgical uses of peroral retrograde pancreatography and cholangiography.


Fiberoptic colonoscopy. A new look at old problems.


Glove starch granulomatous peritonitis.

Glove starch granulomatous peritonitis.


Surgical palliation of massive and severe obesity.


Stress ulcer. A definition, a discussion of other stress-associated upper gastrointestinal lesions, and an experimental model.


The solitary thyroid nodule.

The solitary thyroid nodule.


Rhabdomyosarcoma in children. Improved outlook with a multidisciplinary approach.


A new device for recording pO 2 , pCO 2  and blood flow in focal areas of the myocardium.


Role of electrolyte solutions in treatment of hemorrhagic shock.


Assessment of renal function in surgical patients by urine osmolality concentration tests.


Axillary artery aneurysms secondary to crutch trauma.


Peripheral arterial complications of left heart catheterization and their management.


Formation and size of platelet aggregates during hypovolemic hypotension in dog.


Selective renal arteriography in multiple renal arteries.


The effect of bradycardia on ventricular end-diastolic pressure.


Multiple aneurysms of coronary artery in sclerodermal heart disease.


Diagnostic aids in the management of the vascular patient.


Comparative studies with two pseudomonads on the sequential degradation of aromatic substances metabolized via different pathways.


Properties of rubredoxin and ferredoxin isolated from spirochetes.


Studies on the nature of the Li locus in Trifolium repens L. II. The effect of genotype on enzyme activity and properties.


Polymorphism and linkage for mannosephosphate isomerase in Mus musculus.


Extensive heterozygosity at three enzyme loci in hybrid sunfish populations.


Whose baby is this?

Whose baby is this?


Ten tips on preparing research proposals.


Gestational diabetes--when teaching is important.


Patients' recreational program.

Patients' recreational program.


Daily ICU conference improves patient care.


Health and community information services.


Students on a curriculum revision committee.


Effect of monetary incentive on concept attainment in depressed subjects.


Instrumental control of autonomic responses with the use of a cognitive strategy. A case report.


Behaviour therapy versus drug therapy in the treatment of phobic neurosis.


Declining-dose drug desensitization for phobias. Clinical and psychophysiological studies.


Some polarizations in behaviour therapy and clinical psychiatry.


Lactate infusion in the treatment of 'free-floating' anxiety.


Pathography and psychiatry.

Pathography and psychiatry.


Disaster during psychiatric treatment. An intrapsychic problem for the physician.


Some similarities and differences between obsessional ruminations and morbid preoccupations.


Lithium toxicity occurring with a 'reducing' diet.


Modern woman: implications for psychotherapy.


Critical evaluations: modern woman: implications for psychotherapy.


Behaviour therapy. Reduction of fear: towards a unifying theory.


High resolution studies on the pattern of induced exchanges in the human karyotype.


Specific repression of a puff in the salivary gland chromosomes of Drosophila virilis after injection of glucosamine.


A quantitative study of histones in meiocytes. I. Investigation of the histone amount in cricket spermatogenesis by interference microscopy.


Fine structure of chromosome pairing in ten Ascomycetes: meiotic and premeiotic (mitotic) synaptonemal complexes.


Parthenogenesis in the parasitic and free-living forms of Strongyloides papillosus (Nematoda, Rhabdiasoidea).


Loss of heteropycnosis of the constitutive heterochromatin in specifically activated cells of the thyroid gland of Microtus agrestis.


Puffing in salivary gland chromosomes of picture-winged Hawaiian Drosophila.


Long-term variation in plasma activities of aspartate transaminase and alkaline phosphatase in health.


Neurogenic participation in essential and renovascular hypertension assessed by acute ganglionic blockade: correlation with haemodynamic indices and intravascular volume.


Sympathetic responsiveness to head-up tilt in essential hypertension.


Renin, noradrenaline and adrenaline responses to simulated altitude.


The effect of cold on blood flow in the hand of patients with Raynaud's phenomenon.


The effect in man of (+)-propranolol and racemic propranolol on renin secretion stimulated by orthostatic stress.


The activation of a possible zymogen of renin in rabbit kidney.


Factors influencing the urinary excretion of free catecholamines in man.


Nucleoli in peripheral blood lymphocytes of S-strain mice and changes in them after administration of phytohaemagglutinin, C57-strain mouse spleen homogenate or human albumin.


Detection of tumour-associated transplantation antigen of BO-IV carcinoma on somatic cells of tumour-free syngeneic mice. II. Search for a common antigen in some organs and spontaneous mammary carcinomas.


Enzymatic degradation of DNA and deoxyribonucleoprotein in the presence of polyanions.


Resolving a crisis in the activities therapy department.


The phenomenon of self-perpetuation in Synanon-type drug treatment programs.


Joint treatment of drug addicts and other psychiatric patients.


A multidisciplinary seminar for training in group work.


The collaborative coprofessional: developing a new mental health role.


An analysis of time factors in psychiatric crisis units.


The psychiatrist as classroom teacher: school consultation in the inner city.


Indicating levels of probability in the problem-oriented record.


Investigations into particular human circulatory system phenomena by true computer-man interaction.


Computer maintenance of patient registers in general practice.


The Greeks have a word for it.

The Greeks have a word for it.


Vesico-ureteric reflux in Nigeria--the problems.


Hydatid cyst disease of the liver and its treatment.


Neoplasms of the parotid gland. Review of 185 operated cases.


Against heterologous insemination.

Against heterologous insemination.


Gastric pseudotumor due to lesser peritoneal sac abscess.


Modification of Delorme's resection of rectal mucosa for prolapse of the rectum.


Echinococcus disease of the heart.

Echinococcus disease of the heart.


Bilateral symmetrical gangrene of all toes. Complication of infusion of vasopressor agent in a patient with pre-existing cold injury in both feet.


Tuberculosis of the breast.

Tuberculosis of the breast.


Bilateral sarcoma of the breast.

Bilateral sarcoma of the breast.


Biomechanical significance of the instantaneous center of rotation: the human temporomandibular joint.


Mathematical model of a head subjected to an axisymmetric impact.


Physical properties of the urinary detrusor muscle. A mechanical model based upon the analysis of stress relaxation curve.


Translational motion of the head and trunk during normal walking.


Mechanical properties of orthopedic plaster bandages.


Bone remodeling and piezoelectricity. II.


A model for the human spine during impact including musculature influence.


The use of entry flow equations in studying the uniform entry flow.


Leiomyoma of intestine.

Leiomyoma of intestine.


Glucocorticoid suppression of macrophage migration inhibitory factor. The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophages, nor on the ability of antigen-stimulated peritoneal exudate lymphocytes to produce MIF. Rather, hydrocortisone antagonized directly the inhibitory effect of MIF on the macrophage.


Clocortolone, a new topical steroid in dermatoses.


Modern concepts in obstetrics. Modern standards of antenatal care.


Hypertrophic osteoarthropathy associated with a non-metastasising carcinoma of the oesophagus.


Respiratory diseases in industry. Introductory remarks: goals of the conference.


Nasal mucociliary function and the indoor climate.


The mucociliary stream.

The mucociliary stream.


The respiratory bronchiole as a target organ for the effects of dusts and gases.


Lymphatic transport of fibrous dust from the lungs.


Uranium mining and cigarette smoking effects on man.


Bullous lung disease in short order cooks.


The role of the alveolar macrophage.

The role of the alveolar macrophage.


The effects of cigarette smoking on total body burden and excretion rates of carbon monoxide.


Dose response studies in cotton textile workers.


An industrial study of the biological effects of cotton dust and cigarette smoke exposure.


Organic dust-induced hypersensitivity pneumonitis.


Cigarette smoking, disability days and respiratory conditions.


The mechanism of delayed biologic response following beryllium exposure.


The prohibition of the use of asbestos spray in building construction.


Sputum cytology and occupational pulmonary disease.


Are trace metals associated with asbestos fibers responsible for the biologic effects attributed to asbestos?


Chest auscultation in the diagnosis of pulmonary asbestosis.


Pathology of the lung in tungsten carbide workers using light and electron microscopy.


Exposure, complaints, chest film abnormalities and lung function tests among beryllium workers: preliminary report.


Identification of the quality and quantity of (biologically significant) cotton mill dust.


The Society of Occupational and Environmental Health.


Human responses to isocyanate exposure.

Human responses to isocyanate exposure.


A comparison of the stimulus properties of mescaline and 2,3,4-trimethoxyphenylethylamine.


The role of sulfhydryl groups in three models of inflammatory disease.


Absorption of diethylstilbestrol and its glucuronide conjugate from the intestines of five- and twenty-five-day-old rats.


Retrograde intrabiliary injection: absorption of water and other compounds from the rat biliary tree.


Myocardial effects of imidazole.

Myocardial effects of imidazole.


Binding of cyproheptadine-(N-methyl- 14 C) by human blood platelets: inhibition by phenothiazines and tricyclic antidepressants.


Electrophysiological properties of splenic nerve in relation to norepinephrine overflow.


Long-lasting supersensitivity of the rat vas deferens to norepinephrine after chronic guanethidine administration.


Cell-mediated hypersensitivity and intracellular parasitism.


The actions of 5-hydroxytryptamine on the urinary bladder and on vesical autonomic ganglia in the cat.


The cigarette rearguard action.

The cigarette rearguard action.


Questionnaire pitfalls.

Questionnaire pitfalls.


Dental health of university students.

Dental health of university students.


Trends in legalized abortion in South Australia.


Social medicine in Central Australia. The opportunities of Pitjantjara aborigines.


Ileus in retroperitoneal haematoma.

Ileus in retroperitoneal haematoma.


Toowoomba diabetic survey. A community follow up in 1970.


Variations in the incidence of lipodystrophy using different insulins.


A laminar-flow sterile products department. An example of modern biomedical engineering.


Head injury.

Head injury.


A prescribing hazard.

A prescribing hazard.


Physical illness in psychiatric patients.


Preventive psychiatry.

Preventive psychiatry.


Cot death survey: anaphylaxis and the house dust mite.


Pressurized sympathomimetic aerosols and their lack of relationship to asthma mortality in Australia.


Serum immunoglobulin patterns in the first year of life in normal and low birth weight infants. I. Relationship to birth weight.


Variations in serum cholesterol levels after myocardial infarction.


Listeriosis in man.

Listeriosis in man.


Human fascioliasis in Australia.

Human fascioliasis in Australia.


Tuberculoma of the ciliary body.

Tuberculoma of the ciliary body.


Vesico-vaginal fistula after sexual intercourse.


A multi-access interface for the disabled (MAID).


The management of gonorrhoea and syphilis.


A prescribing "mess" and some "reason" prescribing for emotional disorder.


Sudden collapse after administration of intramuscular iron preparations.


Endotracheal tube swallowed by a neonate.


Hexachlorobenzene pesticides and porphyria.


Neurosis or convulsive disorder?

Neurosis or convulsive disorder?


"Why does this patient have a low serum sodium"?


Postgraduate medical education: the responsibility of the private practitioner.


Clinical trial of a topical foam for episiotomies.


The autopsy is dead.

The autopsy is dead.


Doctors still drink too much and pop too many pills.


The anatomy of male gonorrhea.

The anatomy of male gonorrhea.


What we're learning about methadone and some other addiction programs.


In vivo and in vitro evaluation of liquid antacids.


Postsplenectomy erythrocytosis in hemoglobin Köln disease.


Impaired peripheral chemosensitivity and acute respiratory failure in Arnold-Chiari malformation and syringomyelia.


Malabsorption of crystalline vitamin B 12  in cystic fibrosis.


Gastric analysis: ancient but going strong.


The abortion decisions: the Supreme Court as moralist, scientist, historian and legislator.


Unstable oxygen delivery.

Unstable oxygen delivery.


Salicylate poisoning.

Salicylate poisoning.


Women, pain, and prejudice.

Women, pain, and prejudice.


Androphilic, porcine ads.

Androphilic, porcine ads.


NBT and cell clumping.

NBT and cell clumping.


Problems of sickle-cell screening.

Problems of sickle-cell screening.


Arthropathy in sickle-cell disease.

Arthropathy in sickle-cell disease.


Technics of radioimmunoassay for insulin.


Hepatitis B in infants.

Hepatitis B in infants.


Colonoscopy.

Colonoscopy.


Surgical procedures in a health centre.

Surgical procedures in a health centre.


Salivary tumours.

Salivary tumours.


Six days to Sunday.

Six days to Sunday.


Ketalar--a children's anaesthetic.

Ketalar--a children's anaesthetic.


Pleural effusion.

Pleural effusion.


The hallmark of the nurse: how to develop a professional approach.


A minute for the minutes.

A minute for the minutes.


Making enemies in your sleep.

Making enemies in your sleep.


Going overseas?

Going overseas?


Nursing in Ethiopia.

Nursing in Ethiopia.


Where have all the nurses gone?

Where have all the nurses gone?


Spontaneous renal papillary necrosis in the Gunn rat.


Plasma cell granuloma of the lung: case report.


Studies of muramidase in haematological disorders: serum and marrow muramidase in leukaemia.


Acute inflammation--a combined topographical and electron microscopic study of the mode of action of carrageenan.


Photoalkylation of purines in DNA.

Photoalkylation of purines in DNA.


Photo-C 4 -cycloaddition of psoralen and pyrimidine bases: effect of oxygen and paramagnetic ions.


The photolysis of tryptophan in the presence of oxygen.


Sensitivity of the electron transport chain of pigmented and non-pigmented Sarcina membranes to photodynamic action.


In the groove.

In the groove.


Numerical scale for evaluation of the patient with inflammatory joint disease.


Continuing education in the 1970s.

Continuing education in the 1970s.


Direct method versus underwater method in the treatment of plantar warts with ultrasound. A comparative study.


Cystic fibrosis and the role of the physical therapist in its management.


Wheelchair adaptation for self-propulsion by patient with elbow flexion contractures.


Camera hood for electromyographic units.


Limited bracing of spastic paraplegia.

Limited bracing of spastic paraplegia.


Paget's disease of bone.

Paget's disease of bone.


Bone tumours.

Bone tumours.


Orthopaedics in the tropics.

Orthopaedics in the tropics.


Endocrine bone disease.

Endocrine bone disease.


A simple test of hearing.

A simple test of hearing.


Management of recurrent oral ulceration.


Gross paracetamol overdosage with recovery.


Home management of epidermolysis bullosa.


Treatment of lumbo-sacral disc disorders.


Antibiotics in tonsillitis.

Antibiotics in tonsillitis.


Long-term use of a salbutamol inhaler in general practice.


Clinical toxicology. 3. The treatment of poisoning: what do I do first? I.


Is radiochemistry the ultimate in trace analysis?


Analytical studies of the environment.

Analytical studies of the environment.


Socioeconomic traits in mildly retarded children of differential diagnosis.


Change in the splitting of the second heart sound after operation of atrial septal defects.


Perspectives of patients treated by laterolateral anastomosis between the main bile duct and duodenum for relative indication.


Biliary chloramphenicol excretion. 3. Following intramuscular administration of suspensions of different provenance.


New view of the importance of salivary glands.


Castration in treatment of sex offenders: an appraisal.


Sterilization of the female.

Sterilization of the female.


Constrictive coxsackie pericarditis.

Constrictive coxsackie pericarditis.


I-131 uptake. Revision of normal values for New Mexico.


Incidence of congenital heart disease at Fitzsimons General Hospital. A necropsy study.


Urinary tract infections in childhood.

Urinary tract infections in childhood.


Treatment of advanced carcinoma of the larynx.


Influenza in 1973.

Influenza in 1973.


The treatment of congenital heart disease in infants. Surface cooling, deep hypothermia, limited cardiopulmonary bypass and circulatory arrest.


Anthropometric observations on South African gymnasts.


Trypanosomiasis on the Witwatersrand.

Trypanosomiasis on the Witwatersrand.


A photographic method for recording isodoses through the use of Agfacontour film.


Early effects of  60 Co gamma-radiation on cerebral catecholamines, serotonin and related compounds.


Trimethoprim in veterinary medicine.

Trimethoprim in veterinary medicine.


Neck exploration for hyperparathyroidism.


Nature and treatment of cerebrospinal fluid rhinorrhea in pituitary tumors.


Considerations in the management of thyroid malignancy.


Total mastectomy and partial axillary dissection.


Esophagomyotomy for esophageal achalasia.


Mediastinoscopy.

Mediastinoscopy.


Special techniques in gastric surgery.

Special techniques in gastric surgery.


Essential steps in hepatic resection.

Essential steps in hepatic resection.


Strangulated paraduodenal hernia. Report of a case.


Operative technique in surgery for Crohn's disease and its relationship to recurrence.


Carcinoma of the colon.

Carcinoma of the colon.


Sphincter-saving operations.

Sphincter-saving operations.


The new hemorrhoidectomy.

The new hemorrhoidectomy.


Current considerations in the repair of bile duct strictures.


T-tube cholangiography. Technical considerations for the surgeon.


Surgical exposures for adrenal endocrinopathies.


The surgical approach for total hip replacement.


Techniques in the management of the recurrent vesicovaginal fistula.


Toward fewer complications in surgery.

Toward fewer complications in surgery.


Abortion. The first five years at North Carolina Memorial Hospital.


Mechanism of diabetes in pregnancy and hormonal levels for prediction of fetal outcome.


Breast reconstruction after radical mastectomy.


Management of cervical dysplasia at Parkland Memorial Hospital.


Surgical management of malignant lesions of the skin.


Early detection of fetal heart movement by sonar.


Ultrasonic B-scanning of the heart with an ECG gated television display.


Additives in feed and the E.E.C.

Additives in feed and the E.E.C.


Cleft palate and the use of corticosteroids.


Congenital haemolytic anaemia in Basenjis.


The prophylaxis of ovine fascioliasis by the strategic use of rafoxanide.


Concurrent enzootic ataxia and white muscle disease in a flock of lambs.


An unusual craniobuccal defect in two neonatal lambs.


The transmission of Salmonella dublin to calves from adult carrier cows.


A case of enamel pearls in a dog.

A case of enamel pearls in a dog.


Antibodies to Leptospira grippotyphosa in British wild mammals.


Involvement of diet in fatty liver and kidney syndrome in broiler chickens.


The use of antibiotics in cattle practice.


To Italy--with 120 pigs.

To Italy--with 120 pigs.


The pharmacology of antibiotics as a guide to their use.


The treatment of bovine ringworm.

The treatment of bovine ringworm.


Trimethoprim in veterinary medicine.

Trimethoprim in veterinary medicine.


The importance of pharmacy in the formulation of veterinary products.


The infectivity of the two electrophoretic forms of cowpea mosaic virus.


Anomalies in molecular weight determinations of tobacco rattle virus protein by SDS-polyacrylamide gel electrophoresis.


Electron microscopy of DNA from coliphage N4.


Biogenesis of poxviruses: relationship between a translation complex and formation of A-type inclusions.


Meridional amblyopia: evidence for modification of the human visual system by early visual experience.


The size and shape of influenza virus neuraminidase.


On the functional differences between frontal and lateral visual fields of the pigeon.


Size-selective adaptation: psychophysical evidence for size-tuning and the effects of stimulus contour and adapting flux.


Acuities for spatial arrangement in line figures: human and ideal observers compared.


Characteristics of P- and I-cells of the cat's lateral geniculate body.


The brightness of coloured flashes on backgrounds of various colours and luminances.


On the origin of the receptor potential in the lateral eye of Limulus.


Analysis of transient visual sensations above the flicker fusion frequency.


Visual sensitivity in the presence of alternating monochromatic fields of light.


Training the visual accommodation system.


Scanning and transmission electron microscope studies on the sensory sucker papillae of the fish parasite Entobdella soleae (Monogenea).


Electron microscopic investigations on the suitability of lyophilised dura mater in arthroplastic surgery.


Susceptibility of non-splenectomized and splenectomized Sahiwal cattle to experimental Babesia bigemina infection.


Immunoconglutinin and total conglutinating activity in bovine serum.


Haemolytic and conglutinating complement in bovine serum.


Rupture of arteriosclerotic aortic aneurysm. Description of a patient with aneurysm, rupturing into the duodenum.


Intra-abdominal herniation of the bowel. A late complication of gastric resection.


Release of acid hydrolases during perfusion of pig liver.


Disappearance of intravenously infused acid hydrolases from the circulation in pigs.


Transmural oxygen tensions in the wall of the inferior vena cava. A study with ultramicro oxygen electrodes in rabbits.


Pernicious hyperparathyroidism.

Pernicious hyperparathyroidism.


Evaluation of the  133 Xenon clearance method for measurement of blood flow in the dog spleen.


Normocalcemic primary hyperparathyroidism.


Preperitoneal herniorrhaphy.

Preperitoneal herniorrhaphy.


Blunt pancreatic trauma. Report of sixteen cases.


Effect of parathyroid hormone on the propulsive gastrointestinal motility of the rat.


Influence of parathyroid function on the propulsive motility of the small intestine in the rat.


Gastric perfusion in vivo.

Gastric perfusion in vivo.


The Burge test for completeness of vagotomy.


Capillary filtration in isolated, homologously perfused small intestine.


Fecal incontinence.

Fecal incontinence.


Surgical treatment of fistula-in-ano.

Surgical treatment of fistula-in-ano.


Indications for sphincterotomy in the anal canal.


Treatment of anal incontinence, with integrity of the muscular sphincter.


Distribution of biologically labelled radioactive hyaluronic acid injected into joints.


Cytogenetic and scanning study of patients receiving intra-articular injections of gold-198 and yttrium-90.


Hand measurements in ankylosing spondylitis.


Measurement of inflammation. I. Application of technetium clearance to rheumatoid arthritis and animal models.


Congenital malformations of human dermatoglyphs.


pH-dependence of epidermal respiration under normal conditions and in chemically induced hyperplasia. Comparison with the mitochondrial tetrazolium reduction.


Nutritional rickets at puberty.

Nutritional rickets at puberty.


Family with intermittent maple syrup urine disease.


Mini exchange plasma transfusion.

Mini exchange plasma transfusion.


Heparin therapy in meningococcal septicaemia.


Automated method for exchange transfusion.


Plasma pancreatic glucagon and insulin: glucagon ratio at birth.


Thyroid follicular cell proliferation as a function of age.


Cellular reaction in the human lung caused by inhalation of asbestos dust over long periods.


Aminoacyl transfer from adenylate anhydride to the 2'OH groups along the backbone of polyribonucleotides.


The presence of a common active subunit in low and high molecular weight murine DNA polymerases.


Pyrazomycin B: isolation and characterization of an  -C-nucleoside antibiotic related to pyrazomycin.


Carbon-13 nuclear magnetic resonance spectral analysis of C-nucleosides. The structure of pyrazomycin B 1 .


Pyruvate-supported acetylene and sulfate reduction by cell-free extracts of Desulfovibrio desulfricans.


The synthesis of proteolipid protein by isolated rat liver mitochondria.


Asymmetric phospholipid bilayer membranes: formation and electrical characterization.


The participation of a tryptophan residue in the binding of ferric iron to pyrocatechase.


Studies on the binding of methylmercury by thionein.


Competitive binding of EF1 and EF2 by mammalian ribosomes: role of GTP hydrolysis in overcoming inhibition by EF2 of aminoacyl-tRNA binding.


Increased protein synthetic capacity in vitro of rat liver rough endoplasmic reticulum following starvation.


Experimental determination of the redox potential of the superoxide radical O 2 .


Serum factors stimulating DNA synthesis in the isolated nuclear system from rat liver.


Studies on polyribonucleotides. Synthesis of a polyinosinic: 6-thioinosinic acid copolymer.


Biosynthesis of  -linolenic acid by disrupted spinach chloroplasts.


Sickle hemoglobin gelation--inhibition by tris (hydroxymethyl) aminomethane and sugars.


Induction of benzpyrene hydroxylase in fetal liver explants by flavones and phenobarbital.


Pharmacological disposition in mice of O 2 :2'-anhydro-1- -D-arabinosylcytosine 3'-phosphate, a potential antileukemic agent.


Inhibition of aminoacylation and polypeptide synthesis by chloroquine and primaquine in rat liver in vitro.


Analysis of the purinyl-6-histamine binding to ribonucleic acids.


Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: relationship during enzyme induction and following inhibition of protein synthesis.


Effect of insulin on the metabolism of L-ascorbic acid in animals.


Studies on lysophospholipases. II. Substrate specificity of a lysolecithin hydrolyzing carboxylesterase from beef pancreas.


Effects of antilipolytic agents on glucose utilization by adipose tissue.


Reversible binding of lipoprotein lipase from hen adipose tissue to insolubilized heparin.


Glycolipids of a halotolerant, moderately halophilic bacterium. I. The effect of growth medium and age of culture on lipid composition.


Glycolipids of a halotolerant, moderately halophilic bacterium. II. Biosynthesis of glucuronosyldiglyceride by cell-free particles.


A new procedure for the extraction, purification and fractionation of brain gangliosides.


Identification of molecular species of ceramide aminoethylphosphonate from oyster adductor by gas-liquid chromatography-mass spectrometry.


The formation of 16,17-dihydroxylated C 19  steroids from 16-dehydro C 19  steroids in liver microsomes from male and female rats.


De novo synthesis of cholesteryl esters in previable human foetuses.


Cholesteryl ester synthesis and hydrolysis by subcellular fractions of corpora lutea and interstitial tissue from ovaries of pregnant rabbits.


Effect of cholesterol feeding and biliary obstruction on hepatic cholesterol biosynthesis in the rat.


An evaluation of the chemical identity of acylcarnitine esters of hexadecanoic acids.


Long-chain acyl-CoA hydrolase activity in serum: identity with clearing factor lipase.


Increase in postheparin lipoprotein lipase activity in rat plasma by dietary erucic acid.


A comparison of the relative turnover of individual molecular species of phospholipids in normal rats and in rats deficient in essential fatty acids.


Pathways of phosphatidylcholine biosynthesis in rat liver.


The incorporation of ( 3 H)glucosamine, ( 3 H)fucose and ( 14 C)mannose into protein in the rat anterior pituitary incubated in vitro.


The enzymatic formation of a compound with the expected properties of carboxylated ribulose 1,5-diphosphate.


Exchange of molecular species of phosphatidylcholines and phosphatidylethanolamines between rat liver mitochondria and microsomes in vitro.


Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas.


Mucin of the rat submaxillary gland: influence of the animal's age and sex on the composition of its glucidic fraction.


Measurement of intralysosomal pH.

Measurement of intralysosomal pH.


Investigation of hepatic ATP and glucose 6-phosphate as indices of hypoglycin toxicity.


Properties and subcellular distribution of enzymes required for acetoacetate biosynthesis in chicken liver.


Induction and activation of cysteine oxidase of rat liver. II. The measurement of cysteine metabolism in vivo and the activation of in vivo activity of cysteine oxidase.


Mechanism of sex difference in rat tissue iron stores.


Influence of thiols, ATP and CoA on protein breakdown by subcellular fractions from rat liver.


Studies on the control of gluconeogenesis in sheep: effect of glucose infusion.


Relation between diet and protozoal population in the rumen.


Studies on the control of gluconeogenesis in sheep: effect of propionate, casein and butyrate infusions.


Dental caries and plaque formation from diets containing sucrose or glucose in gnotobiotic rats infected with Streptococcus strain IB-1600.


Effects of magnesium deficiency on reproduction in the white rat.


Seasonal variations in glucose metabolism of reindeer (Rangifer tarandus L.) estimated with (U- 14 C)glucose and (3- 3 H)glucose.


Iron metabolism in the veal calf. The availability of different iron compounds.


The effect of a traditional low-fat diet on energy and protein intake, serum albumin concentration and body-weight in Ugandan preschool children.


The use of a semi-synthetic liquid diet for the supply of ethanol to rats and its effect on lysosomal enzyme activities in the liver.


Changes in the activity of citrate lyase, malic enzyme and acetyl-CoA synthetase in rat liver after short-term and long-term feeding with ethanol.


Degradation of nucleic acids in the rumen.


Dissimilation of 1,2-propanediol by rumen micro-organisms.


Adenocarcinoma and Crohn's disease. A report of 2 cases and analysis of the literature.


The arterial complications of polycythaemia vera.


High blood viscosity: an aetiological factor in venous thrombosis.


The effect of antral acidification on acid secretion stimulated by pentagastrin.


Further progress with reconstruction of the exstrophied bladder.


An analysis of 59 cases of tracheal stenosis following tracheostomy with cuffed tube and assisted ventilation, with special reference to diagnosis and treatment.


Acalculous gall-bladder disease.

Acalculous gall-bladder disease.


Closed liver injury: an assessment of prognostic factors.


The coagulum pyelolithotomy.

The coagulum pyelolithotomy.


Coeliac and hepatic nerve function following selective vagotomy.


'Fruit-stone ileus'.

'Fruit-stone ileus'.


Glove-powder granuloma of the testis after surgery.


Neurilemmoma presenting as a lump in the breast.


Horseshoe kidney and abdominal aortic aneurysm.


Primary adenocarcinoma arising in a vitello-intestinal duct remnant at the umbilicus.


Chlorambucil vs. combined chlorambucil-corticosteroid therapy in chronic lymphocytic leukemia.


Longitudinal bone marrow chromosome studies in potential leukemic myeloid disorders.


Hodgkin's disease in children.

Hodgkin's disease in children.


Prenatal stilbestrol experience of mothers of young cancer patients.


Diethylstilbestrol in pregnancy. Frequency of exposure and usage patterns.


Colorimetric response to Ehrlich's reagent in plasma from patients with and without cancer.


Parathyroid carcinoma. A study of 70 cases.


Cancer of the colon in South Saskatchewan. A population study.


Colorectal cancer in Rochester, Minnesota 1940-1969.


Osteoclastoma-like giant cell tumor of the thyroid. Report of a case with prolonged survival following partial excision and radiotherapy.


Paralytic brachial neuritis in Hodgkin's disease.


Postoperative irradiation in carcinoma of the endometrium.


Treatment of carcinoma of the hypopharynx.


A case control study of cancer of the pancreas.


Female adnexal tumor of probable Wolffian origin. A distinctive pathologic entity.


Secondary chemotherapy of advanced breast cancer.


Ovarian teratoma and neuroglial implants on the peritoneum.


The in vitro localization of H 3  estradiol in human prostatic carcinoma. An electron microscopic autoradiographic study.


Squamous carcinoma arising in the pituitary gland.


Breast cancer with axillary metastasis in an eight and one-half-year-old girl.


Carcinoma of Meckel's diverticulum.

Carcinoma of Meckel's diverticulum.


Prolonged survival in malignant pheochromocytoma of the organ of Zuckerkandl with pharmacological treatment.


Inferior myocardial infarction. Correlation of selective cine coronary arteriographic and ventriculographic findings with form of QRS complex in lead AVF.


Studies in multiple myeloma. I. Characteristics by immunoglobulin class.


Informed consent and special procedures.


Athletic injuries of the shoulder.

Athletic injuries of the shoulder.


Pelvic lipomatosis.

Pelvic lipomatosis.


Geometric total knee replacement in osteoarthritis.


Studies in multiple myeloma. II. Light chains.


Implementing programs for young hearing impaired children.


A mediated training program for parents of the preschool mentally retarded.


Proposed CEC policy statement on the organization and administration of special education.


The spatial organisation of the excitatory region of receptive fields in the cat's superior colliculus.


Single unit and evoked potential responses in cat optic tract to paired light flashes.


Quantitative study of anatomical distribution of respiration related neurons in the pons.


Electron microscopic tracing of pathogenetic events in intestinal chlamydial infections of newborn calves.


Ultrastructural analysis of phospholipase A induced changes in membranes of synaptic regions in rat motor cortex.


Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.


Benzisothiazole-3-carboxylic aminoesters. Synthesis and preliminary experiments on pharmacological activity of quaternary ammonium salts.


The search for new drugs in the group of xanthine derivatives. XXXVII. 7-Hydroxybutyltheophyllines.


Neurotropic and psychotropic agents: 9-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin. (Preliminary communication).


Enzymatic hydrolysis of penicillin G and other phenylacetylamino compounds by Neurospora crassa acylase.


Submicroscopic localization of acid phosphatase in the dental cyst epithelium.


Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytochemical marker system.


Evidence for the presence of DNA in the centrosomal plaques of Ascobolus.


Lymphocyte transformation in chronic renal failure.


Photographing the secondary fluorescence of potato wart fungus resting sporangia in color.


Photography of ultrasound scans in diagnostic ophthalmology.


Impact of color microfiche on medical education, research, and record.


Science and scientists: neither goblins nor good fairies.


DNA:anti-DNA complexes: their detection in systemic lupus erythematosus sera. Antibody to DNA was measured before and after treatment of systemic lupus erythematosus (SLE) sera with bovine pancreatic deoxyribonuclease (DNase I). In 11 of 15 cases of SLE with active renal disease there was a significant increase in DNA-binding after DNase digestion, while no such increase was noted in inactive SLE, normal controls or in patients with nonlupus renal disease. The significant rise in DNA-binding after digestion indicated that DNA had bound in vivo to the anti-DNA in these sera. A striking correlation between the occurrence of these complexes and disease activity was shown. In eight cases of SLE nephritis where serial blood samples were obtained, the greatest increase in DNA-binding after DNase digestion occurred at the time of the severest renal disease. In addition, serum from a case of SLE with acute cerebritis but without evidence of renal disease also had a significant rise in binding during the acute phase. This assay provides proof of the existence of circulating DNA:anti-DNA complexes in some cases of SLE and can also be used to measure an apparently critical parameter of disease activity.


Effects of glutamine deamination on glutamine deamidation in rat kidney slices. Glutamate is known to inhibit the activity of isolated glutaminase I; however, its actual physiologic importance in regulating renal ammoniagenesis has not been established. To determine the regulatory role of glutamate on the metabolism of glutamine by rat kidney slices, we followed the effects on glutamine (2 mM) deamidation of increased removal of glutamate via augmented deamination. Three agents (malonate, 2,4-dinitrophenol, and methylene blue) were known to and shown here to hasten exogenous glutamate deamination. In slices from 10 control rats, 21.5+/-1.7 (SEM) mumol/g of ammonia were formed from amide nitrogen and 9.3+/-0.5 (SEM) mumol/g from the amino nitrogen of glutamine in vitro. Over 90% of the glutamine deamidated formed glutamate at one point in its catabolism. After addition of malonate (10 mM), 2,4-dinitrophenol (0.1 mM), or methylene blue (0.5 mM), the production of ammonia from the amino group rose to 29.3+/-6.0 (SEM) mumol/g, 20.0+/-1.8 (SEM) mumol/g, and 15.5+/-4.2 (SEM) mumol/g, respectively; ammonia production from the amide nitrogen rose also, 45.1+/-7.3 (SEM) mumol/g, 39.7+/-2.6 (SEM) mumol/g, and 41.9+/-3.7 (SEM) mumol/g. In the case of the former two, a minimum of 99% and 75% of the glutamine catabolized formed glutamate. Despite increased glutamine catabolism, there was no build up of glutamate in the media. A correlation between the formation of ammonia from the amino and amide nitrogen was apparent. Since none of the three agents selected affected phosphate activated glutaminase I activity directly or appeared to affect glutamine transport, we interpret the increase in deamidation as an expression of deinhibition of glutaminase I activity secondary to lowered glutamate concentrations at the deamidating sites through more rapid removal of glutamate via hastened deamination. Interestingly, slices removed from acidotic rats produced more ammonia from both the amino 29.1+/-3.8 (SEM) and amide nitrogens 45.9+/-4.3 (SEM) of glutamine, without a buildup of glutamate in the medium. At least 90% of the glutamine deamidated formed glutamate. A common mechanism is proposed to explain these results and the previous ones.


Determination of iodothyronine absorption and conversion of L-thyroxine (T 4 ) to L-triiodothyronine (T 3 ) using turnover rate techniques. The absorption of L-thyroxine (T(4)) and L-triiodothyronine (T(3)) and the fractional rate of conversion of T(4) to T(3) were determined from the turnover rates of T(4) and T(3) in seven patients without endogenous thyroid function during separate treatment periods with these iodothyronines. Serum T(3) concentration was measured by a radioimmunoassay procedure in which the iodothyronines are separated from the plasma proteins before incubation with anti-T(3) antibody. Metabolic clearance rates were calculated by an integral (noncompartmental) approach since the use of single compartment kinetics led to a 40% overestimation of the metabolic clearance rate of T(3). Based on the amount of hormone ingested and the observed hormonal turnover rates, the absorption of T(4) and T(3) (iodothyronine turnover/iodothyronine ingested) in man could be estimated. Absorption of T(3) was complete in three subjects but decreased to 43% in a fourth who was suffering from mild congestive heart failure. Mean T(4) absorption was 48.0+/-2.6% (SEM) for seven subjects. The mean fractional rate of T(4) to T(3) conversion determined during T(4) replacement therapy (T(3) turnover/T(4) turnover) was 42.6% (range 30.7-50.8%). Thus, approximately one-half of the T(4) which was deiodinated was converted to T(3) suggesting that monodeiodination is an obligatory step in the peripheral metabolism of T(4). Calculations based on these results together with other available data suggest that under normal physiologic circumstances the major portion of the T(3) pool is derived from monodeiodination of T(4).


Effect of intraluminal flow on proximal tubular reabsorption. Micropuncture techniques in the rat were used to reinvestigate the possibility that intraluminal flow rate per se may influence net volume reabsorption by the proximal tubule. An experimental design was devised which lowered intraluminal flow without affecting filtration rate of the nephron under study or without directly affecting other renal hemodynamics. In 11 rats flow of tubular fluid between early and late proximal tubular sites was reduced by partially collecting tubular fluid at the early puncture site. In 42 nephrons the rate of flow of tubular fluid was reduced an average of 45% without changing nephron filtration rate and there was an associated reduction in reabsorption between the two sites which averaged 29%. This indicated 63% balance between delivery of tubular fluid and the rate of reabsorption between two sites along proximal tubules. The results of these studies indicate that a reduction in delivery of normal filtrate along the proximal tubule is associated with a concordant reduction in the absolute rate of reabsorption. Since this relationship occurred in the absence of changes in renal hemodynamics or even a change in filtration rate of the nephron under study it is concluded that changes in intraluminal load per se play an important role in the phenomenon of glomerulotubular balance.


Tubuloglomerular feedback. Nonlinear relation between glomerular hydrostatic pressure and loop of henle perfusion rate. The present experiments were performed to quantify the effect of changes in distal tubular sodium delivery on glomerular flow dynamics both below and above the normal physiologic range. Glomerular capillary pressure as derived from the tubular stop flow pressure was assessed while the loop of Henle of the same nephron was perfused with varying flow rates. During Ringer perfusion no change of glomerular capillary pressure was observed when flow was increased from 0 to 13 nl/min. Further increasing flow to 27 nl/min was associated with a reduction of glomerular hydrostatic pressure by an average of 7.0+/-4.4 cm H(2)O (+/-SD). During perfusion at a rate of 43 nl/min glomerular pressure was decreased by a mean of 10.5+/-4.0 cm H(2)O. Changing the flow rate in small steps revealed that a significant reduction of capillary pressure was found when increasing the flow rate from 13 to 21 nl/min and that the maximum response was reached at 32 nl/min. No effect of perfusion rate changes on glomerular capillary pressure was observed when 300 mM mannitol was used as perfusion fluid. These results imply that a nonlinear relationship exists between end-proximal flow rate and glomerular capillary pressure. It is suggested that during deviations of distal sodium delivery into a positive direction filtration rate is intrarenally regulated probably by prevalence of afferent arteriolar constriction. During reductions of distal sodium load intrarenal regulation is either abolished or it involves proportionate resistance changes of both afferent and efferent arterioles.


Erythrocyte catabolism by macrophages in vitro. The effect of hydrocortisone on erythrophagocytosis and on the induction of heme oxygenase. Phagocytosis of erythrocytes was studied in vitro in an incubation system consisting of rat peritoneal macrophages and antibody-coated (59)Fe-labeled erythrocytes. The system was characterized in terms of the rate and magnitude of erythrophagocytosis, determined by the interiorization of the (59)Fe label. On incubation of 150 x 10(6) macrophages with 75 x 10(6) antibodycoated erythrocytes, erythrophagocytosis began within a few minutes and was essentially completed after 2 h when 50% of the offered red cells had been ingested by the macrophages. Heme oxygenase (HO) activity, which is very low in native macrophages, increased 4- to 10- fold in response to the ingested erythrocytes; this enzyme stimulation occurred with a delay of 3 h in relation to erythrophagocytosis. Actinomycin D or puromycin prevented the increase of HO activity without affecting erythrophagocytosis, which suggests that the enzyme stimulation was due to substrate-mediated enzyme induction. Hydrocortisone (HC) (0.1 mg/ml medium) dissociated erythrophagocytosis from HO induction, leaving the former unimpaired but completely suppressing the latter. The suppressive effect of HC on the enzyme induction was completely prevented by 5 mg glucose and 0.02 U insulin/ml of the medium. In macrophages engaged in erythrophagocytosis. HC also lowered glucose removal from the medium and reduced formation of (14)CO(2) from [1-(14)C]glucose. These results suggest that induction of HO in macrophages by the hemoglobin of ingested erythrocytes requires intact transport or metabolism of glucose. Glucose utilization appears to be impaired by HC, but is restored by additional glucose and insulin. The findings suggest that plasma steroid concentrations in the pharmacological range could reduce bilirubin formation in phagocytic cells in vivo without affecting the sequestration and degradation of erythrocytes. This provides a possible explanation for the observation that in patients with hepatogenous jaundice, steroids often lower the serum bilirubin level.


The glucose receptor. A defective mechanism in diabetes mellitus distinct from the beta adrenergic receptor. Acute serum insulin responses in 10 normal subjects after rapid intravenous injection of glucose (5 g) or isoproterenol (2 mug) were of similar magnitude and timing (glucose: 431+/-349%; mean Delta3-5' insulin (IRI)+/-SD, per cent basal and isoproterenol: 359+/-216%; mean Delta2-4' IRI+/-SD, per cent basal). To elucidate the relationship of glucose-induced insulin secretion to pancreatic beta adrenergic receptors and the implications of this relationship with regards to abnormal insulin secretion in diabetes mellitus, two questions were studied. (a) To determine whether glucose-induced insulin secretion is dependent upon beta adrenergic activity, the effect of beta adrenergic blockade with intravenous propranolol (0.08 mg/min) upon acute insulin responses to isoproterenol and glucose were compared in normal subjects. (b) To determine whether acute insulin responses to beta adrenergic stimulation were intact in diabetes mellitus, the effect of isoproterenol upon serum insulin levels was studied in diabetic subjects. Beta adrenergic blockade in the normal subjects obliterated acute insulin responses to isoproterenol (before: 361+/-270%, during: - 31+/-15%; n = 6, P < 0.001) but did not significantly affect responses to glucose (before; 311+/-270%; during: 284+/-206%; n = 5). The mean acute insulin response after isoproterenol in the diabetic group was significantly elevated over basal levels (152+/-74%; n = 10, P < 0.001) but the response after glucose was not (- 11+/-11%). These data suggest that insulin responses to glucose in normal subjects are mediated by specific pancreatic glucose receptors which are independent from beta adrenergic receptors and that abnormal glucose-induced insulin secretion in diabetics is due to defects within glucose receptors and not beta adrenergic receptors as has been previously hypothesized.