New horizons in medical ethics. Research investigations in children.


Iatrogenic disease in general practice: its incidence and effects. A year's survey of iatrogenic disease in general practice showed that one consultation in every 40 was the result of iatrogenic disease. Iatrogenic disease may affect the doctor/patient relationship, often leading the doctor to feel guilty or the patient to become aggressive.


Reorganization--1974 or 1984? Background to reorganization.


Prevention of pulmonary embolism.

Prevention of pulmonary embolism.


Elective surgical treatment of duodenal ulcer.


Stress and myocardial infarction.

Stress and myocardial infarction.


Research investigations in adults.

Research investigations in adults.


Treatment of S.L.E. nephritis.

Treatment of S.L.E. nephritis.


Surface particls on leukaemic lymphocytes.


Treatment of systemic lupus erythematouss.


Mut of malady.

Mut of malady.


Shake test on amniotic fluid and the respiratory distress syndrome.


Fungal infections of the spine.

Fungal infections of the spine.


Pulmonary embolism from a femoral bypass.


Cerebrospinal fluid in virus meningitis.


Seebohm and the N.H.S: a survey of medico-social liaison.


Metabolism of iphosphamide (2-(2-chloroethylamino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) and production of a toxic iphosphamide metabolite.


Increased immunosensitivity in nitrogen mastard-resistant Yoshida sarcoma.


Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low levels of vitamin A.


Studies on tryptophen metabolism in patients with bladder cancer.


Depression of antilymphoma allograft reactivity by tumor-associated factors.


Late ultrastructural changes induced by 12-O-tetradecanoyl-phorbol-13-acetate in mouse epidermis and their reversal.


Inhibition by progesterone of radiation-estrogen-induced mammary cancer in the rat.


Correlations between oncogenic and chemical properties of several derivatives of 3-hydroxyxanthine and 3-hydroxyguanine.


Relationship of DNA repair to carcinogenesis in xeroderma pigmentosum.


Differential release of sialic acid from normal and malignant cells by Vibrio cholerae neuraminidase or influenza virus neuraminidase.


Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.


Scheduling of arabinosylcytosine and 6-thioguanine therapy.


Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.


Evaluation of aniline mustard in patients with multiple myeloma.


Avoiding unnecessary scars.

Avoiding unnecessary scars.


The treatment of winged-scapula.

The treatment of winged-scapula.


Normal ranges of hip motion in the newborn.


Pigmented villonodular synovitis occurred in a rheumatoid patient. A case report.


Peripheral joint manifestations of acromegaly.


Osteoblastoma of the spine. A review and report of eight new cases.


Bilateral rupture of the infrapatellar tendon in rheumatoid arthritis.


Experiences with dome shaped osteotomy of upper tibia for multiplane correction.


Surgical approaches to the anterior structures of the cervical spine.


Passage of calcium and strontium across the intestine in man.


Anterior approach to the thoraco-lumbar junction of the spine by a retroperitoneal-extrapleural technic.


Chloroquine: protective and destructive effects on injured rabbit cartilage in vivo.


Symposium on new surgical approaches.

Symposium on new surgical approaches.


A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. 3. Accumulation of acid soluble collagen with a high hydroxylysine content in bone.


The microstructure of poly-methylmethacrylate cement.


Surgical approaches to the shoulder.

Surgical approaches to the shoulder.


Effect of low doses of disodium ethane-1-hydroxy-1, 1-diphosphonate on disuse osteoporosis in the denervated cat tail.


Cellular proliferation in the formation of fracture callus in the rat tibia.


Extensive exposure of the hip joint.

Extensive exposure of the hip joint.


Treatment of axial deviations of the knee joint by means of intercondylar femoral osteotomies.


Symposium. Diverse methods of managing hemorrhoids.


Ultraviolet spectra of rat kidney lipids after carbon tetrachloride administration.


Bronchial gland measurements: a continuing search for a "yardstick".


Use of aortic medial explants in the study of atherosclerosis.


Partial purification of a mitotic suppressor from the salivary gland.


A modification of the Charnley method for compression arthrodesis of the knee.


Diverse methods of managing hemorrhoids: ligation with cryotherapy.


[Nonparasitic cysts of the liver].

[Nonparasitic cysts of the liver].


Diverse methods of managing hemorrhoids: cryohemorrhoidectomy.


Diverse methods of managing hemorrhoids: surgical treatment.


Diverse methods of managing hemorrhoids: dilatation.


Reversible ischemic colitis: report of four cases.


Malacoplakia of the colon: report of a case, with a review of eight previous case reports.


Voluntary dislocation of the shoulder. A preliminary report on a clinical, electromyographic, and psychiatric study of twenty-six patients.


Ganglionic cystic defects of bone.

Ganglionic cystic defects of bone.


Progessive diaphyseal dysplasia. Review of the literature and report of seven cases in one family.


Osteogenesis imperfecta. A histopathological case report.


Relief of pain by anterior cervical-spine fusion for spondylosis. A report of sixty-five patients.


Surgery of the rheumatoid knee. Synovectomy and débridement.


Syme's amputation in insensitive feet. A review of twenty cases.


Long-term results of femoral-head replacement.


Marginal osteophyte excision in treatment of mucous cysts.


Barton's fractures.

Barton's fractures.


Heparin osteoporosis. An experimental model using rats.


Phenol nerve block in the treatment of acquired spastic hemiplegia in the upper limb.


Pathological fracture in long bone sarcoidosis. Report of a case.


Destructive arthritis of the large joints. A rare manifestation of sarcoidosis.


Acute osteomyelitis adjacent to the sacro-iliac joint in children. Report of two cases.


Brain abscess complicating the use of halo traction.


Osteochondroma of the cervical spine.

Osteochondroma of the cervical spine.


Air splints for long-term management of osteogenesis imperfecta.


Traumatic atlanto-axial dislocation without neurological disorder. A case report.


Osteoarthritis of the hip and other joints in southern Chinese in Hong Kong.


Studies of the in vivo metabolism of mevalonic acid in the normal rat. Studies were performed to examine synthesis, tissue localization, and metabolism of mevalonic acid in normal rats. Circulating mevalonate was found to have a rapid turnover phase of 5 min and a slower phase of 40-50 min. Under in vitro conditions the synthesis of mevalonate is carried out most actively by the liver and only to a minor extent by the other tissues studied. The most unexpected finding of this study was that both in vivo and in vitro the kidneys rather than the liver are the primary site of the metabolism of circulating mevalonate. Whereas mevalonate in the liver is rapidly transformed to cholesterol, the major products of mevalonate metabolism in the renal tissues during the same time period are squalene and lanosterol. Exogenous in contrast to circulating mevalonate is metabolized primarily in the intestine.


Effect of changes in hydrostatic pressure in peritubular capillaries on the permeability of the proximal tubule. The effect of increased hydrostatic pressure in the peritubular vessels on net sodium reabsorption from the proximal tubule was examined in the Necturus. An increase in the pressure gradient of 2.0 cm H(2)O across the wall of the proximal tubule, produced by ligation of the postcaval vein was associated with a marked reduction in net reabsorption and an increased back flux of water and electrolytes. This change was accompanied by a slight, but significant drop in the transepithelial electrical potential but not by an alteration in the steady-state chemical gradient. These studies highlight the importance of changes in the permeability characteristics of the proximal tubule on net sodium transport.


Effects of cortisone administration on the metabolism and localization of 25-hydroxycholecalciferol in the rat. Glucocorticoid administration is known to decrease calcium absorption in vivo and the vitamin D-dependent active transport of calcium by rat duodenum in vitro. The basis for this antivitamin D-like effect of glucocorticoids is unclear. Previous studies in the rat failed to demonstrate an effect of glucocorticoid treatment on the hepatic conversion of the parent vitamin to 25-hydroxycholecalciferol (25-HCC). Moreover, pharmacologic doses of 25-HCC did not restore intestinal calcium transport to normal. The results of these experiments suggested that if indeed glucocorticoids interfere with the metabolism of vitamin D, the step involved must be subsequent to 25-hydroxylation. The present studies demonstrate that the administration of cortisone to vitamin D-deficient rats does not affect the rate of conversion of a physiologic dose of [(3)H]25-HCC to the biologically important metabolite, 1,25-dihydroxycholecalciferol (1,25-DHCC). Furthermore, pretreatment with glucocorticoids affects neither the tissue distribution nor the subcellular localization on or in intestinal mucosal cell nuclei of 1,25-DHCC. Of note is the fact that 1,25-DHCC is currently considered to be the "tissue-active" form of the vitamin in the intestine. Whereas tissues from cortisone-treated animals had increased concentrations of the biologically less active 24,25-DHCC, the physiologic significance of this observation remains unclear. The results of the present studies strongly support the concept that the antivitamin D-like effects of glucocorticoids in the intestine are due to hormonal influences on the biochemical reactions responsible for calcium transport. While the effects of these hormones are opposite in direction to those of vitamin D, they occur by a mechanism that is independent of a direct interaction with either the vitamin or its biologically active metabolites.


Proximal tubule potential difference. Dependence on glucose on glucose, HCO 3 , and amino acids. The effect of various intraluminal substrates on the magnitude of the transepithelial potential difference (PD) across the proximal convoluted tubule (PCT) of the mammalian kidney was investigated in two ways. First, the transepithelial PD was measured before and after the removal of glucose, bicarbonate, and alanine from the lumen. Second, the effects of specific transport inhibitors-ouabain, phloridzin, and acetazolamide-was ascertained when placed either on luminal or blood side. Isolated segments of rabbit PCT were perfused in vitro. Tubules perfused with isosmolar ultrafiltrate (UF) at rates > 10 nl/min had a mean PD of - 5.8+/-0.2 mV (lumen negative). Normal UF was simulated by an artificial perfusion solution. Using the latter, observed PD was - 5.4+/-0.2 mV. A significant reversible decrease in PD was noted when the following constituents were removed singly: glucose (from - 5.7+/-0.4 to - 3.5+/-0.4 mV); alanine (from - 5.8+/-0.4 to - 4.7+/-0.3 mV); and bicarbonate (from - 5.3+/-0.3 to - 3.3+/-0.5 mV). The combined removal of alanine and glucose (replaced with mannitol) reduced the transepithelial PD to - 0.5+/-0.1 mV with removal of glucose and alanine (replaced with mannitol) and decrease of NaHCO(3) to 5.6 meq/liter (replaced with NaCl), as normally occurs in early part of in vivo PCT, resulted in reversible change of PD from - 5.1+/-0.2 to + 3.2+/-0.2 mV. Ouabain (10(-5) M) reversibly decreased the negative control PD from blood side, but had no effect from luminal side. Phloridzin (10(-5) M) reversibly decreased PD from - 6.4+/-0.3 to - 3.7+/-0.4 mV when placed on luminal side but had minimal effect from blood side, - 6.3+/-0.4 to - 5.8+/-0.4 mV. Acetazolamide (Diamox) was without effect from either side. Reversal of bulk flow of water by addition of 31 mosmol/liter raffinose to perfusion ultrafiltrate did not significantly decrease the PD. It is concluded that specific pumps for transport of glucose, amino acids, and bicarbonate exist on the luminal surface. All three constituents are necessary for expression of maximum PD. Removal of these substrates by transport changes PD from - 5.1 mV to + 3.2 mV (lumen positive). This 3.2 mV positive PD is secondary to a chloride diffusion potential and is not effected by ouabain from the blood side.


Origins of the uricosuric response.

Origins of the uricosuric response. The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excretion of filtered urate, then the uricosuric responses (the increment in urate excretion or clearance) should have been unaffected by PZA. Defined in this manner, however, uricosuric responses to probenecid and chlorothiazide were significantly decreased after PZA pretreatment. In order to determine whether PZA diminished other renal actions of chlorothiazide, changes in sodium and inorganic phosphorus excretion were examined. Chlorothiazide produced equivalent natriuretic and phosphaturic responses after PZA pretreatment, indicating that PZA does not interfere with at least some of the renal actions of chlorothiazide. In separate studies, PZA depressed urate excretion by at least 68% during the maintenance of chlorothiazide-induced natriuresis and phosphaturia, suggesting that chlorothiazide does not diminish the anti-secretory action of PZA. The results suggest that probenecid and chlorothiazide may derive their uricosuric properties by facilitating the excretion of both filtered and secreted urate. Possibly, increased excretion of secreted urate might occur through modulation of urate reabsorption at a site distal to tubular secretion, rather than by the direct acceleration of secretory transport. However, PZA-induced interference with the actions of probenecid and chlorothiazide on renal urate transport mechanisms cannot be excluded as a possible explanation for the present results.


Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation. Highly purified inhibitor of the first component of complement (CāINH) was shown to inhibit the capacity of active Hageman factor fragments to initiate kinin generation, fibrinolysis, and coagulation. The inhibition of prealbumin Hageman factor fragments observed was dependent upon the time of interaction of the fragments with CāINH and not to an effect upon kallikrein or plasmin generated. The inhibition of the coagulant activity of the intermediate sized Hageman factor fragment by CāINH was not due to an effect on PTA or other clotting factors. The inhibition by CāINH of both the prealbumin and intermediate sized Hageman factor fragments occurred in a dose response fashion. The CāINH did not appear to be consumed when the activity of the Hageman factor fragments was blocked, although the fragments themselves could no longer be recovered functionally or as a protein on alkaline disc gel electrophoretic analysis. These results suggest that the CāINH may have an enzymatic effect on the fragments or that an additional site on CāINH is involved in Cā inactivation.


The different effects on the serum lipids and fecal steroids of high carbohydrate diets given orally or intravenously. The hypothesis that diets high in carbohydrate produce hyperlipidemia in man was tested in new experiments which provided all calories either by the intravenous route or orally. After a base-line general diet, eight healthy men were fed fat-free diets consisting of 80% of the calories from glucose and 20% from an amino acid hydrolysate. The calories were adequate to maintain body weight. The solutions (1 cal/ml) were infused by constant drip over a 24 h period through either a superior vena cava catheter or a nasogastric tube. Each feeding was for 12 days in sequence but assigned in random order. The high CHO diet given orally, as expected, increased the mean base-line serum triglyceride level from 176+/-29 (SE) to 274+/-47. The identical diet given intravenously (i.v.) failed to produce hypertriglyceridemia; triglyceride levels were not significantly changed, 154+/-37, nor were blood glucose levels. Serum insulin levels were higher during the intravenous feeding. In contrast, both i.v. and oral feedings greatly lowered mean serum cholesterol concentration from the base-line value of 220+/-13 mg/100 ml to 135+/-11 and 151+/-13, respectively. However, the serum cholesterol level was significantly lower (P < 0.01) with the intravenous feeding than with the oral feeding. In addition, the fecal excretion of both neutral sterols and bile acids diminished greatly during the period of intravenous feeding. The fecal mass was likewise decreased. The bacterial conversion of cholesterol to conprostanol did not occur with either intravenous or oral feeding, but with both regimens secondary bile acids predominated, as usual, in the bile acid fraction of the stool. These results emphasize the key role of the intestinal mucosa in the etiology of carbohydrate-induced hypertriglyceridemia and as a direct or indirect contributor to plasma triglyceride and cholesterol levels in the absence of dietary lipids. When the gut mucosa was bypassed, carbohydrate-induced hypertriglyceridemia did not occur and both serum triglyceride and serum cholesterol levels decreased greatly at a time when the excretion of steroids in the stool was also reduced.


In vitro myelosuppression and immunosuppression by ethanol. Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitro findings may relate to in vivo effects of ethanol on myeloid and lymphoid tissue.


The effect of gastrin on basal- and glucose-stimulated insulin secretion in man. The effect of gastrin on basal- and glucose-stimulated insulin secretion was studied in 32 normal, young subjects. The concentration of gastrin and insulin in serum was measured radioimmunochemically. Maximal physiologic limit for the concentration of gastrin in serum was of the order of 160 pmol per liter as observed during a protein-rich meal. Oral ingestion of 50 g glucose produced a small gastrin response from 28+/-3 to 39+/-5 pmol per liter (mean +/-SEM, P < 0.01). Intravenous injection or prolonged infusion of gastrin increased the concentration of insulin in peripheral venous blood to a maximum within 2 min followed by a decline to basal levels after a further 10 min. The minimum dose required to induce a significant insulin response (31.2 ng gastrin per kg) increased the gastrin level in serum above the physiologic range. Maximum effect was obtained with 500 ng gastrin per kg. When 15.6 ng (7.1 pmol) gastrin per kg body weight and 25 g glucose were injected simultaneously, the glucose-induced insulin response was potentiated (from 2.32+/-0.33 to 4.33+/-0.98 nmol per liter per 20 min, P < 0.02), even though gastrin concentrations only increased to 71.2+/-6.6 pmol per liter. No effect, however, was noted on glucose disposal. 15.6 ng gastrin per kg given i.v. 30 min before an i.v. glucose tolerance test was without significant effect on the insulin response. The results indicate that gastrin can stimulate a rapid and short-lived release of insulin. In physiologic concentrations gastrin potentiates the glucose-stimulated insulin secretion and is without effect on basal insulin secretion. A small release of gastrin during oral glucose ingestion may to a limited extent contribute to the nonglycemic insulin secretion. During protein ingestion, gastrin probably stimulates insulin secretion significantly.


Beta-thalassemia in the American Negro.

Beta-thalassemia in the American Negro. In Italian patients with high hemoglobin A(2) beta-thalassemia trait, the synthesis of beta-chains of adult hemoglobin in the peripheral blood is approximately one-half that of alpha-chains. In this study the relative rates of beta- and alpha-chain synthesis were determined in 26 Negro heterozygotes and five homozygotes for beta-thalassemia in six families. The beta/alpha ratio of globin synthesis was decreased in only 15 heterozygotes, whereas in the other 11, beta/alpha globin synthesis was in the normal range or was slightly increased. These unusual findings did not appear to be due to the presence of alpha-thalassemia or a hyperactive "normal" beta-allele. This study demonstrates that the beta/alpha ratio of globin synthesis in the peripheral blood is normal in some patients with beta-thalassemia trait. In five Negro homozygotes with relatively mild clinical disease the beta/alpha ratios were similar to those of Caucasians with Cooley's anemia. Further studies are needed to explore the relationship between normal synthesis ratios in many Negro heterozygotes and milder clinical disease in homozygotes in the same families.


Effect of phloretin on water and solute movement in the toad bladder. It is generally believed that urea crosses the cell membrane through aqueous channels, and that its movement across the membrane is accelerated in the direction of net water flow (solvent drag effect). The present report presents evidence for a vasopressin-sensitive pathway for the movement of urea, other amides, and certain non-amides, which is independent of water flow. Phloretin, when present at 10(-4) M concentration in the medium bathing the luminal surface of the toad bladder, strongly inhibits the movement of urea, acetamide, and propionamide across the toad bladder, both in the absence and presence of vasopressin. The vasopressin-stimulated movement of formaldehyde and thiourea is also reduced. Osmotic water flow, on the other hand, is not affected; nor is the movement of ethanol and ethylene glycol, or the net transport of sodium. On the basis of these studies we would conclude that the movement of many, if not all, solutes across the cell membrane is independent of water flow, and that a vasopressin-sensitive carrier may be involved in the transport of certain solutes across the cell membrane.


A micropuncture study of potassium excretion by the remnant kidney. In order to study the mechanism of enhanced potassium excretion by the remaining nephrons of the remnant kidney, micropuncture and clearance experiments were carried out in rats after surgical ablation of 3/4 of the total renal mass. The potassium intake in all animals was approximately 5 meq/day. Animals were studied 24 h and 10-14 days after 3/4 nephrectomy. Balance measurements in the chronic animals before micropuncture study indicated that 24 h K(+) excretion by the remnant kidney was equal to that of the two kidneys before ablation of renal mass. Measurements of distal tubular inulin and potassium concentrations revealed progressive reabsorption of potassium in this segment of the nephron in both the 24-h and chronic 3/4-nephrectomized rats, as well as in normal control rats. A large increase in tubular fluid potassium content occurred between the end of the distal tubule and the final urine in the 3/4-nephrectomized rats, but not in the normal controls. These observations suggest that the segment of the nephron responsible for enhanced potassium excretion by remaining nephrons was the collecting duct. In additional experiments, potassium was completely eliminated from the diet of chronic 3/4-nephrectomized rats before micropuncture study. In these animals, no addition of K(+) occurred beyond the distal tubules. Normal rats infused with 0.15 M KCl to acutely elevate serum K(+) concentration, demonstrated reabsorption of K(+) in the distal tubule and a large addition of K(+) to the urine beyond the distal tubule. We conclude that the collecting duct is the major site of regulation of urinary potassium excretion in normal rats and is responsible for the adaptation to nephron loss by the remnant kidney.


Dynamics of glomerular ultrafiltration in the rat. IV. Determination of the ultrafiltration coefficient. Pressures and flow rates were measured in accessible surface glomeruli of mutant Wistar rats under conditions deliberately designed to prevent achievement of filtration pressure equilibrium, that is, the equalization of transcapillary hydrostatic and oncotic pressures by the efferent end of the glomerulus as typically observed in the normal hydropenic rat. Disequilibrium was obtained at elevated levels of glomerular plasma flow (GPF) brought about by acute expansion of plasma volume with a volume of rat plasma equal to 5% of body weight. Glomerular hydrostatic and oncotic pressures measured at high GPF were used to calculate the ultrafiltration coefficient, K(f), the product of effective hydraulic permeability and surface area. GPF was then either lowered (by aortic constriction) or raised (by carotid occlusion) in order to examine the dependence of K(f) on GPF. The value of K(f) per glomerulus, 0.08 nl/(s.mm Hg), was found not to vary over an approximately twofold range of GPF. This finding, taken together with data from previous studies from this laboratory, leads us to conclude that plasma-flow dependence of glomerular filtration rate (GFR) results primarily from flow-induced changes in mean ultrafiltration pressure, rather than large changes in K(f).


The bioassay of growth hormone in Snell's dwarf mice: effects of thyroxine and prolactin on the dose-response curve.


Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. The development and validation of a direct method for measuring maximum cholesterol solubility in bile is described. Application of this method to five large mammalian species, including man, produced a micellar zone significantly smaller than that previously reported. Further studies on in vitro model solutions patterned after bile confirmed this new micellar zone. Thus, direct evidence demonstrates that the micellar zone boundary derived in vitro from model solutions is applicable to human gallbladder bile. Using the present criteria, normal human bile, in contrast to bile from other mammalian species, is commonly supersaturated with cholesterol. A male-female difference in bile composition is not demonstrable despite the well-established female preponderance of cholelithiasis. Bile from patients with cholesterol cholelithiasis has a micellar zone similar to normals but differs compositionally in that there is a greater excess of cholesterol above saturation. We conclude that cholesterol supersaturation may be a necessary but not solely sufficient cause for gallstone formation.


Evidence for a postsecretory reabsorptive site for uric acid in man. The effects of administration of drug combinations on uric acid excretion were studied in order to test the hypothesis that a portion of renal tubular reabsorption of uric acid occurs distal to the uric acid secretory site. Oral administration of pyrazinamide (3 g) during probenecid uricosuria (probenecid 500 mg every 6 h) decreased urate excretion from 463 mug/min following probenecid medication alone to 135 mug/min following probenecid plus pyrazinamide (P < 0.01). When a greater uricosuric effect was induced with a 2 g oral dose of probenecid, the decrement in urate excretion which followed pyrazinamide administration (3 g) was more pronounced (2,528 mug/min following probenecid alone, 574 mug/min following probenecid plus pyrazinamide). Results were similar when an 800 mg oral dose of sulfinpyrazone was given in place of probenecid (1,885 mug/min following sulfinpyrazone alone, 475 mug/min following sulfinpyrazone plus pyrazinamide). Thus, apparent urate secretion (measured as the decrease in excretion of urinary uric acid resulting from pyrazinamide administration) appeared to vary, depending upon the degree of inhibition of reabsorption produced by probenecid or sulfinpyrazone. When small doses of aspirin were administered in place of pyrazinamide to produce secretory inhibition, the results were similar. Neither probenecid nor pyrazinamide significantly altered urate excretion when administered to patients with serum salicylate levels above 14 mg/100 ml. These results are interpreted as suggesting that renal tubular reabsorption of uric acid occurs at least in part at a postsecretory site and that a portion of secreted urate is reabsorbed. During maximum probenecid- or sulfinpyrazone-induced uricosuria, inhibition of urate secretion with either pyrazinamide or low doses of aspirin resulted in a decrease in uric acid excretion which exceeded total urinary uric acid during control periods by two- to fourfold. This suggests that renal tubular secretion of urate may greatly exceed uric acid excretion and that a large fraction of secreted urate is reabsorbed. The pyrazinamide suppression test underestimates urate secretion. Uricosuria induced by some drugs, including probenecid, sulfinpyrazone, and iodinated radioopaque dyes, appears to represent, at least in part, inhibition of postsecretory urate reabsorption.


The effect of methylcholanthrene on biliary thyroxine excretion in normal and Gunn rats.


The biosynthesis of thyroxine incorporation of (U- 14 C) tyrosine into thyroglobulin by mouse thyroid glands in vivo and in vitro.


Uptake and interconversion of tritiated oestrone and oestradiol-17  in the intact rabbit in vivo.


DNA synthesis in the endometrium of progesterone-treated mice.


Formation of progesterone and pregnenolone from (4- 14 C) cholesterol by the intact mid-term human foeto-placental unit perfused in vitro.


Disappearance of endogenous renin from the circulation after nephrectomy in previously hepatectomized or colonectomized dogs.


The secretory response of the x-irradiated testis to human chorionic gonadotrophin in dogs.


Levels of oestrogen and progesterone in the plasma of the cow during the last month of pregnancy.


Involvement of the uterine blood vessels in the refractory state of the uterine stroma which follows oestrogen stimulation in progesterone-treated mice.


Further studies on cholinergic mechanisms and hormone-activated copulatory behaviour in the female rat.


Inhibitory effect of 5 -reduced metabolites of testosterone on gonadotrophin secretion.


Diurnal changes of plasma cortisol levels in sheep adapting to a new environment.


Side-chain cleavage of (26- 14 C) cholesterol by rat testicular tissues and their subcellular fractions.


Plasma luteinizing hormone and oestrogen in foetal and maternal sheep.


Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes. Corticosteroids and splenectomy constitute two important therapeutic modalities in the treatment of autoimmune hemolytic anemia. Each of these may affect both the rate of synthesis of autoantibody and the clearance of antibody sensitized cells. The latter possibility has been examined in an experimental model which allows evaluation of the role of antibody and complement in the immune clearance of erythrocytes in molecular terms. The in vivo clearance of (51)Cr-labeled guinea pig erythrocytes sensitized with purified rabbit IgG or IgM antibody to produce a known number of complement-fixing sites per cell was studied. Corticosteroid therapy increased the survival of both IgG and IgM sensitized erythrocytes by decreasing sequestration in the reticuloendothelial system (RES). 5 days of therapy prior to injection of antibody coated cells were required for a maximal effect. It appeared that the RES of cortisone-treated animals had a lowered sensitivity to erythrocytes coated with antibody and complement and the cells were removed as though they were coated with fewer complement sites/cell. The general pattern and kinetics of clearance and the localization of sequestered cells were not modified by corticosteroids. As the number of IgG C1-fixing sites was increased, the difference betwen cortisone treated and control animals was less marked. Splenectomy led to an increased survival of IgG-coated cells and a sixfold increase in IgG C1-fixing sites was necessary in order to obtain similar rates of clearance in splenectomized and control animals. The liver was responsible for this much less efficient clearance of cells in splenectomized animals: the clearance pattern was typical of that noted for IgG. No effect at all was noted on the clearance of IgM sensitized cells in splenectomized animals. These experiments clearly demonstrate that both corticosteroid therapy and splenectomy act to decrease the in vivo clearance of IgG-sensitized cells: only corticosteroids alter the clearance of IgM-sensitized erythrocytes. This effect may be of major importance in explaining the efficacy of these therapeutic modalities in autoimune hemolytic anemia.


Further evidence of inherent testicular rhythms in the laboratory rat.


Uptake and retention of ( 3 H) oestradiol by myometrial and deciduomal tissue in the pseudopregnant rat.


The effect of oestrogen and progesterone on uterine cell division and epithelial morphology in spayed-hypophysectomized rats.


Inactivation of pineal antigonadotrophin by proteolytic enzymes.


Saluretic action of aldosterone in the presence of excess cortisol: restoration of salt-retaining action by prolactin.


Plasma oestriol in pre-eclampsia.

Plasma oestriol in pre-eclampsia.


Plasma oestriol concentration during normal pregnancy.


Changes in unconjugated oestrogens and progesterone concentration in plasma at the approach of labour.


The effect on continuous lumbar epidural analgesia on maternal acid-base balance and arterial lactate concentration during the second stage of labour.


The effect of continuous lumbar epidural analgesia on the acid-base status of maternal arterial blood during the first stage of labour.


A scoring system for the assessment of multiple methods of monitoring fetal growth.


Abruption of the placenta. A review of 189 cases occurring between 1965 and 1969.


The effect of vaginal bleeding in early pregnancy on the infant born after the 28th week of pregnancy.


A study of placental size and chorio-amnionitis in a consecutive series of hospital deliveries.


The endometrial karyotypic profiles of women after clomiphene citrate therapy.


Closed system of bladder irrigation and drainage after major vaginal surgery.


Postabortal posterior colpotomy and sterilization.


Uretero-uterine fistula after lower segment Caesarean section.


A case of abdominal pain and jaundice in severe pre-eclampsia.


Injuries of the cervix after induced midtrimester abortion.


The permeability of keratinized and nonkeratinized oral epithelium to horseradish peroxidase.


The structure of icosahedral cytoplasmic deoxyriboviruses. II. An alternative model.


Fine structure of the ordinary lateral line organ. I. The neuromast of lamprey, Entosphenus japonicus.


The prolonged grief reaction.

The prolonged grief reaction.


Pyogenic liver abscess.

Pyogenic liver abscess.


Abuse of prescription drugs.

Abuse of prescription drugs.


Cholic acid therapy for constipation. A controlled study.


Dr. Atkins' diet revolution.

Dr. Atkins' diet revolution.


Subtypes of Australia antigen among patients and healthy carriers in Copenhagen. A relation between the subtypes and the degree of liver damage in acute viral hepatitis.


Sickle-cell anemia and other hemoglobinopathies. Procedures and strategy for screening employing spots of blood on filter paper as specimens.


Medical assessment by a Delphi group opinion technic.


Notes of a biology-watcher. Computers.

Notes of a biology-watcher. Computers.


The Delphi procedure: knowledge from goat viscera?


Endotoxin and endotoxemia.

Endotoxin and endotoxemia.


Blind as a clinical investigator.

Blind as a clinical investigator.


Newborn screening for metabolic disorders.


Colchicine for Mediterranean fever.

Colchicine for Mediterranean fever.


Bacterial infection in sickle-cell disease.


Properdin levels in pneumonia.

Properdin levels in pneumonia.


Chest pain with pulmonic stenosis.

Chest pain with pulmonic stenosis.


Problems with lidocaine therapy.

Problems with lidocaine therapy.


Neutrophil clumping in NBT tests.

Neutrophil clumping in NBT tests.


Colonoscopic polypectomy: a caveat.

Colonoscopic polypectomy: a caveat.


Human rights and research.

Human rights and research.


Doctors and the draft.

Doctors and the draft.


Cancer and the nurses social role.

Cancer and the nurses social role.


Still's disease.

Still's disease.


The befrienders.

The befrienders.


Better nursing communication: by-product of improving patient care.


Briggs: the context. 1. Resources for training.


An honoured profession.

An honoured profession.


The top drugs: Aldomet--a new role.

The top drugs: Aldomet--a new role.


Obesity in a child of eleven.

Obesity in a child of eleven.


Obesity in childhood.

Obesity in childhood.


The registration and inspection of nursing homes.


Studying at home.

Studying at home.


Reactive depression in a psychopathic personality.


Automatic library.

Automatic library.


The new èlites.

The new èlites.


Teach-in: Joint Board of Clinical Nursing Studies. 2. Curriculum planning.


Manpower and training requirements in pediatric cardiology.


How "regular" is the "regular source of medical care"?


Reducing the literal and human cost of child abuse: impact of a new hospital management system.


The working mother and child neglect on  the Navajo reservation.


Treatment of apnea in neonates with an automated monitor-actuated apnea arrestor.


Transient monosaccharide intolerance in a newborn infant.


A pediatrician's guide to the recognition and initial management of early infantile autism.


Two current poisonings: tricyclic drugs and methadone.


Pediatric cardiology revisited.

Pediatric cardiology revisited.


Diagnostic use of iodine 131 in children. Safety and utility compared to other tests.


Complete heart block after cardiac catheterization: a rare complication.


Urinary tract involvement in epidermolysis bullosa.


Urinary vaginal reflux in children.

Urinary vaginal reflux in children.


Sjögren's syndrome and achalasia of the cardia in two siblings.


American Academy of Pediatrics. Policy statement on day care.


Corticosteroids as primary therapeutic agents in respiratory distress syndrome (RDS).


Safety clips prevent hemorrhage.

Safety clips prevent hemorrhage.


Congenital dyserythropoietic anemia.

Congenital dyserythropoietic anemia.


Treatment and prolonged observation of urinary tract infections.


Cushing's Syndrome, therapy or remission?


Quantitative estimation of a primate-specific esterase in normal and malignant tissue.


Effect of replacement of medium potassium by sodium, cesium or rubidium on in vitro iodide transport and iodoamino acid synthesis by rat thyroid.


Responses in hypophysectomized rats implanted with plerocercoids of the tapeworm, Spirometra mansonoides.


Posthypercapnic myocardial potassium movements.


Pigeon crop sac stimulation due to a factor produced by plerocercoids of the tapeworm, Spirometra mansonoides.


Bovine serum LH, GH, and prolactin during late pregnancy, parturition and early lactation.


Inactivation of gastrin and pentagastrin by tissue slices.


Effects of maternal dietary restriction on hydroxyproline levels in urine and tissues of the young.


Colony-stimulating and inhibiting factors in sera from normal and endotoxin-treated CF 1  mice.


Intrathyroidal recycling of iodide in the rat: effects of goitrogens.


Increased preference for Na +  and K +  salts in spontaneously hypertensive (SH) rats.


Response of the opsonic and phagocytic system to trauma in adrenalectomized animals.


Binding of cyproterone acetate to plasma proteins.


Characterization of an obese syndrome in the pig.


Role of autonomic pathways in disuse atrophy of rat parotid.


Brain ribosomal RNA synthesis inhibited by chlorpromazine.


Acute lethality for mice following administration of cyclophosphamide with barbiturates.


Effects of indomethacin on the pulmonary vascular and air way resistance responses to pulmonary microembolization.


Marked phenylalanyl-tRNA activity of herpesvirus type 2 infected preparations.


The immunosuppressive effect of dactinomycin on experimentally induced granulomas--a quantitative study.


Isolation of hydromorphone and dihydromorphine glucuronides from urine of the rabbit after hydromorphone administration.


Effects of lead on heme-synthesizing enzymes and urinary  -aminolevulinic acid in the rat.


Microcytotoxicity tests on human cells in culture: effect of contamination with mycoplasma.


The relationship between cytotoxicity and interferon induction in L-M strain mouse fibroblasts.


The effect of changes in antral pH on the basal release of gastrin.


Immunologically specific activation of macrophages armed with the specific macrophage arming factor (SMAF).


The effects of cardiac denervation on body fluids.


Effect of dietary monosodium glutamate and cholesterol on growth and lipid metabolism in the rat.


Methylazoxymethanol-acetate induced neurotoxicity of chick embryos.


Venous arterial interactions involving serotonin in the pampiniform plexus of the rat.


Investigations on the mode of action of endogenous mediator.


Development and regression of murine leukemia induced by friend virus complex.


Chick aorta pyrophosphatase.

Chick aorta pyrophosphatase.


Influence of temperature on glutamate catabolism and glycogen production by organisms of the genus Chlamydia.


Optical density measurements in canine tibias in situ.


Effect of cholestyramine on fecal bile salt excretion in rats fed diets containing medium-chain triglycerides or corn oil.


In vitro binding of mixed micellar solutions of fatty acids and bile salts by cholestyramine.


An epizootic of dermatophytosis caused by Trichophyton simii in poultry.


Cryptococci of commercial bird feeds. II. Cryptococcus spp. in association with milo (Sorghum vulgare var. subglabrescens).


Dermatophytes in Portugal.

Dermatophytes in Portugal.


Production of capsule and conidia by yeast-like cells of Phialophora spinifera and Phialophora jeanselmei.


Transmission and course of Trichophyton erinacei infections in British hedgehogs.


Accountability, emphasis for the future.


Effects of continuous light and total darkness on cultures of Histoplasma capsulatum.


Mating reactions in the Trichophyton terrestre complex.


Prison without bars. Human communication disorders.


Effects of pH and temperature on the in vitro growth of Sporothrix schenckii.


Sociolinguistics and the practice of speech pathology.


Community oriented research.

Community oriented research.


Cryptococcosis in a field mouse.

Cryptococcosis in a field mouse.


Noise pollution: hearing conservation.

Noise pollution: hearing conservation.


Rehabilitative audiology.

Rehabilitative audiology.


Amniotic membranes as a temporary wound dressing.


Deaf unit speaks for itself.

Deaf unit speaks for itself.


The physiologic status of the anorectum after pull-through operations.


A new breed in rehabilitation.

A new breed in rehabilitation.


Efficacy of steroids in the treatment of septic and cardiogenic shock.


The use of arteriovenous autograft and allograft fistulas for chronic hemodialysis.


Effect of skin dressings and topical antibiotics on healing of partial thickness skin wounds in rats.


Evidence that a diminished bile acid pool precedes the formation of cholesterol gallstones in man.


Occlusion of the hepatic artery in man.

Occlusion of the hepatic artery in man.


Levodopa test to predict response of carcinoma of the breast to surgical ablation of endocrine glands.


Is primary fibrinolysis a real entity?

Is primary fibrinolysis a real entity?


Routine operative cholangiogram.

Routine operative cholangiogram.


Technical suggestions for saphenous vein bypass operations.


Postoperative biliary drainage.

Postoperative biliary drainage.


Variceal hemorrhage, hepatic cirrhosis, and portacaval shunts.


Effect of transabdominal vagotomy on the human gastroesophageal high-pressure zone.


Recurrence of venous thromboembolism.

Recurrence of venous thromboembolism.


Carcinoid tumors of the appendix.

Carcinoid tumors of the appendix.


Renal revascularization for arteriosclerotic renovascular hypertension: prognostic implications of focal renal arterial vs. overt generalized arteriosclerosis.


Surgical treatment of bile duct strictures.


Pancreatic trauma: management and presentation of a new technique.


The use of biopsies in burn patient care.


A computer simulation model to study the clinical observability of ventilation and perfusion abnormalities in human shock states.


The continuing development of the technique of thyroidectomy.


Natural intestinal infection with Chlamydia psittaci in a closed bovine herd: serologic changes, incidence of shedding, antibiotic treatment of the herd, and biologic characteristics of the Chlamydiae.


Anthelmintic efficacy of morantel tartrate in cattle.


Pathogenicity of a strain of Chlamydia psittaci of bovine intestinal origin for neonatal calves.


Respiratory fluctuations in durations of phases of ventricular systole in the dog.


Action of certain antiprotozoal compounds against Babesia gibsoni in dogs.


Parenteral use of medroxyprogesterone acetate as an antifertility agent in the bitch. 10 kg unbred Beagle and mongrel bitches were used in each of 4 experiments (exp).  6 alpha-methyl-17 alpha-acetoxyprogesterone (MAP or medroxyprogesterone acetate) was prepared as a sterile aqueous suspension (50 mg/ml) and was used in exps 1, 2 and 3.  Tritiated MAP was used in exp 4.  In exp 1, 7 bitches were given 500 mg and 7 were given 50 mg subcutaneously (sc).  6 controls were used.  In exp 2, 50, 100 or 250 mg were given sc, intramuscular (im) or intraperitoneal (ip) to 4 dogs at each dose level and route of administration.  In exp 3, 12.5 or 25 mg was given either sc or im in 4 groups of 8 bitches each.  In exp 4, a single 50 mg mixture of MAP and tritiated MAP was given to each of 3 dogs: 1 sc, 1 im, and 1 ip.  Results of exp 1 showed those on 500 mg had first posttreatment estrus an average of 504 days (range of 247-730) after injection.  Those on 50 mg averaged 329 days (range of 205-429).  Breeding resulted in 6 live pups/litter for the controls 5.2 for those on 50 mg, and 4 for those on 500 mg.  In exp 2, results showed prolonged cycling in those injected sc (295 days to estrus), while those injected im reached estrous in 225 days and those injected ip in 148 days.  In exp 3, 3 on 25 mg sc had a 6 month estrous delay while 4 did when injected im.  3 of 16 given 12.5 mg sc and im had a 6 month delay in cycling.  Exp 4 showed ip treated dogs had estrus 148 days after treatment, 225 days for im, and 295 days for sc.  Ip treated dogs whelped 5 pups; im 7 pups; and sc, 5 pups.  7 months lapsed before nearly all of the 50 mg sc administered dose was excreted.  An additional 2.5 months lapsed before estrus occurred in this dog.


Evaluation of pharmacologic agents for restraint in cystometry in the dog and cat.


Ganglia in the middle ear of the dog.

Ganglia in the middle ear of the dog.


Population control and the women of India.


Expanding the pharmacist's prerogatives.


The expanding role of chain drug stores in health care.


Stock for restraint of dog during lymphatic duct drainage and other minor surgical procedures.


Scanning electron microscopic features of Haemobartonella felis.


Passive hemagglutination test for histoplasmosis, using histoplasmin-sensitized formalinized sheep erythrocytes.


Intranuclear annulate lamellae in giant cells of the mouse chorioallantoic placenta.


Lymphoid cells in the turtle bladder.

Lymphoid cells in the turtle bladder.


An unmet professional obligation.

An unmet professional obligation.


Changes in the protein content of blastocysts from normal and delayed implanting mice.


Thyroxine and the development of the tibia in the embryonic chick.


Ultrastructural morphology of the normal nasal respiratory epithelium of the mouse.


Penetration of the testicular-tubular barrier by horseradish peroxidase induced by adjuvant.


Intracordal polytef (teflon) injection. Histologic study of two cases.


Nasotracheal intubation in acute epiglottiditis.


Incubator noise and possible deafness.

Incubator noise and possible deafness.


Risks of head and neck surgery in previously irradiated patients.


The meaning of pH.

The meaning of pH.


Tympanic cavity obliteration for cerebrospinal otorhinorrhea.


Cervical sympathectomy in Meniere's disease.


The current status of nickel carcinogenesis.


Characterization of serum alkaline phosphatase of hepatobiliary and osteoblastic origin.


Surgical management of the carotid sinus syndrome.


Measurement of regional pulmonary function by the use of isotopes.


The diagnosis of fungal infections of the respiratory tract.


Congenital ear anomalies associated with otic meningitis.


T-tube for middle ear ventilation.

T-tube for middle ear ventilation.


Cranial metaphyseal dysplasia. Otolaryngologic aspects.


Sudden conductive hearing loss following sneezing.


The structure of the primary lung lobule.


Klippel-Feil syndrome and associated hearing loss.


Pathologic quiz case.

Pathologic quiz case.


Simultaneous squamous carcinoma and adenocarcinoma of the larynx.


Symptomatic elongated styloid.

Symptomatic elongated styloid.


Inner ear barotrauma.

Inner ear barotrauma.


Serous otitis.

Serous otitis.


Diagnosing acoustic neuroma.

Diagnosing acoustic neuroma.


Schwannoma of the nasal cavity.

Schwannoma of the nasal cavity.


Enzymic reduction of free fatty aldehydes in bovine cardiac muscle.


Tight binding of oxaloacetate to succinate dehydrogenase.


Stimulation of the activities of solubilized pig lymphocyte RNA polymerases by phytohaemagglutinin.


Shortening velocity of collagen and muscle fibers.


Magnetic circular dichroism of non-heme iron proteins.


Biosynthesis of 5-methylaminomethyl-2-thiouridylate. I. Isolation of a new tRNA-methylase specific for 5-methylaminomethyl-2-thiouridylate.


Poly adenylic acid sequences in mitochondrial RNA.


Changes in lipid composition of tritosomes during lysis.


Circular dichroism of a membrane protein of Neurospora crassa.


-S-cysteinyl-5,6-dihydrothymine: a possible model for radiation-induced cross-linking of DNA and protein.


Structural proteins of spring viremia virus of carp.


Interaction of phenol with the polysaccharide of bacteria cell wall.


Protein synthesis in rabbit reticulocytes: control of protein synthesis initiation by a met-tRNA Met  f  deacylase and peptide chain initiation factors.


A protein-nucleic acid crosslink in 30S ribosomes.


Densitization of pyruvate carboxylase against acetyl-CoA stimulation by chemical modification.


Solubilization and partial characterization of the tetrodotoxin binding component from nerve axons.


Polyene antibiotic action on lecithin liposomes: effect of cholesterol and fatty acyl chains.


Reversible inactivation and superactivation by covalent modification of thermolysin.


Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.


Sequential induction of two species of lipoprotein lipase.


Structure of the ornithine-containing lipid from Rhodopseudomonas spheroides.


Reversal by CoA of palmityl-CoA inhibition of long chain acyl-CoA synthetase activity.


In vitro studies on the metabolism of hexadecanedioic acid and its mono-L-carnitine ester.


Synthesis of fatty acid esters of short-chain alcohols by an acyltransferase in rat liver microsomes.


Effect of double and triple bonds in fatty acid inhibitors upon desaturation of stearic acid by rat liver microsomes.


Triglyceride digestion and absorption in the locust, Locusta migratoria.


Regulation of lipolysis in bovine adipose tissue by the degree of saturation of plasma albumin with fatty acids.


Solution properties of taurine and glycine conjugates of fusidic acid and its derivatives.


Solubilization of  -carotene and retinol into aqueous solutions of mixed micelles.


The role of copper in prostaglandin synthesis.


Characterization of the lipid composition of squid rhabdome outer segments.


Synchronization of hepatic cholesterol synthesis, cholesterol and bile acid content, fatty acid synthesis and plasma free fatty acid levels in the fed and fasted rat.


Public or community health?

Public or community health?


Differences in metabolism of cholesterol and sitosterol following intravenous injection in rats.


Parents' attitudes towards the nurse as physician associate in a pediatric practice.


Hospitalization after motor vehicle accidents in Nova Scotia.


The use of computers in assisting school health programs in Ontario.


Carbon monoxide and nitrogen dioxide exposure of Montreal longshoremen.


A survey of pediatric hospital utilization by Indian children in British Colombia.


Chronicity and recurrence of psittacosis.


Dermatophytoses in Alberta (1959-1971).

Dermatophytoses in Alberta (1959-1971).


Use of incident light in fluorescent microscopy for the identification of human chromosomes.


Eastern equine encephalomyelitis in Eastern Canada--1972.


Some lessons in Soviet and Canadian health experiences.


Westmount prenatal class survey.

Westmount prenatal class survey.


The nurse specialist or clinician in public health nursing.


Cigarette smoking: a child's guide to addiction.


Cigarette smoking during pregnancy and the effect upon the fetus.


Screening for lung cancer.

Screening for lung cancer.


Smoking habits of grade 7 children--a comparative study.


Reinforcement of a smoking withdrawal program: the role of the physiologist and the psychologist.


A study in smoking withdrawal: the Toronto smoking withdrawal study centre--description of activities.


Prophaylactic antibiotics.

Prophaylactic antibiotics.


Surface area of the hand and digits.

Surface area of the hand and digits.


Chronic or recurring organoaxial rotation of the stomach.


Relationship between vagotomy, peptic ulcer and gastric adenocarcinoma in rats fed 2,7-diacetylaminogluorene.


Gastrointestinal nematodes in horses in Ontario.


Protection of Arizona-disease infected turkey poults.


North American blastomycosis in two dogs in Saskatchewan.


Electrophysiologic mechanisms for conduction abnormalities.


The role of spontaneous diastolic depolarization in second degree A-V block: the mechanism of "paroxysmal" A-V block and of a new form of pseudo-supernormal A-V conduction.


Instant physiology.

Instant physiology.


Ventricular contraction--an important adjunct to sub-endocardial perfusion.


The variable effect of smoking on pulmonary function.


The mechanism of intermittent bundle branch block: relationship to prolonged recovery, hypopolarization and spontaneous diastolic depolarization.


Paroxysmal atrioventricular block related to hypopolarization and spontaneous diastolic depolarization.


Unusual coronary emboli associated with coronary arteriography.


Flexible fiberoptic bronchoscopy. Techniques and review of 100 bronchoscopies.


Silo filler's disease.

Silo filler's disease.


Diurnal variation of plasma catecholamines and systolic time intervals.


Thromboembolism following heart valve replacement by prosthesis: survey among 365 consecutive patients.


Surgical management of acute septic pericarditis.


Sympathetic innervation of the ductus arteriosus in relation to patency.


The penumoconioses: methods of measuring progression.


A role for the carotid body in cardiovascular control in man.


Intraventricular conduction intervals during orthograde conduction in patients with complete heart block.


Pyrogen reactions from cardiac catheterization.


Apathetic hyperthyroidism presenting as tricuspid regurgitation.


Pulmonary disease manpower survey. Report of the Joint Committee, American Thoracic Society, American College of Chest Physicians.


Atrioventricular sequential pacing and pacemakers.


An arterial blood gas diagram for clinical use.


Interpretation of the arterial oxygen and carbon dioxide partial pressures. A simplified approach for bedside use.


Roentgenogram of the month. Bilateral nodular thoracic densities in an edematous hypertensive woman.


Valve replacement in rheumatic heart disease.


Double midsystolic clicks in ischemic heart syndromes.


Controlled low-flow oxygen in the management of acute respiratory failure.


Simultaneous recording of timed biplane Frank vectorcardiograms and the His bundle electrogram.


Mesothelioma of the atrioventricular node.


Esophageal duplication cyst with unusual manifestations.


Pacemaker-induced electrocardiographic changes simulating myocardial infarction.


The retrotracheal triangle.

The retrotracheal triangle.


Survival through conus artery collateralization in severe coronary heart disease.


Rupture of a congenital aneurysm of the left ventricular apex.


The paradoxic effect of tolazoline hydrochloride on pulmonary hypertension of mitral stenosis.


Wenckebach periods in posterior inferior division of left bundle.


Primary alveolar hypoventilation in a thin young woman.


The mechanism of bronchial breathing.

The mechanism of bronchial breathing.


Urinary homogentisic acid: determination by thin-layer chromatography.


Microdiffusion method for estimation of cyanide in whole blood and its application to the study of conversion of cyanide to thiocyanate.


Trace-element contamination in biopsies of the liver.


Quantitative determination of serum triglycerides by the use of enzymes.


Estimation of norms from a controlled sample survey. II. Influence of body habitus, oral contraceptives, and other factors on values for the normal range derived from the SMA 12-60 screening group of tests. The Westenberg-Mood 2-sample percentile test was used to determine if ranges of normal values for subgroups varied for variables measured on the SMA 12/60 ("AutoAnalyzer 12/60", analyzes serum).  Data on 12 frequently determined serum constituents was collected from people age 20-49.  Subjects were clinically normal men (423) and women (557).  Individuals were subgrouped according to 1) sex, 2) geographical region of the U.S., 3) body habitus (weight), 4) season of the year when serum was drawn, 5) time of day, and 6) medications, if any, being used.  Some of the more striking observations were 1) obese persons had higher concentrations of uric acid, 2) albumin and inorganic phosphate concentrations were decreased in women using oral contraceptives, and 3) lactate dehydrogenase activities  were lower in the winter months.  A laboratory test has increased usefulness when the normal range is narrowed; analysis of serum constituent levels in subgroups achieves this purpose.


Rapid method for quantitative determination of propoxyphene in serum by gas-liquid chromatography.


Accurate micromethod for estimation of both medium- and long-chain fatty acids and triglycerides in fecal fat.


A modified indirect method for determining erythrocyte sodium and potassium concentrations.


Determination of serum calcium by use of an AutoAnalyzer I-II hybrid.


Automated atomic absorption spectrophotometry.


An automated procedure, with use of ferrozine, for assay of serum iron and total iron-binding capacity.


Determination of uric acid in serum, with use of uricase and a tribromophenol-aminoantipyrine chromogen.


Formaldehyde interference in the uric acid-phosphotungstic acid redox.


Comparison of results for three method of hemoglobin S identification.


Stability of sera.

Stability of sera.


Assay of erythromycin esters.

Assay of erythromycin esters.


Posible error resulting from use of "Nitrogen-filled" Vacutainers for blood-gas determinations.


Plasma kininogen in patients with myocardial infarction.


The influence of vitamin B 15  on myocardial contractility and cardiotonic effect of strophanthin in ischaemic heart disease.


The values of arterio-bronchial and arterio-thoracic ratios in the x-ray estimation of pulmonary haemodynamics in children with congenital heart disease.


Blood and urine catecholamines in recent myocardial infarction, after attack of angina pectoris, and in non-cardiac pain (pleuritis).


The influence of thyroid hormones on the activities of the certain enzymes in rat aorta at a high-fat diet.


Bovine abortions in five Northeastern states, 1960-1970: evaluation of diagnostic laboratory data.


Experimental zinc deficiency in weanling pigs on high and low calcium diets.


The proteins of the embryonic chick epidermis. I. During the normal development in ovo.


Early effects of vitamin A on protein synthesis in the epidermis of embryonic chick skin cultured in serum-containing medium.


The proteins of the embryonic chick epidermis. II. During culture in serum-containing medium with and without added vitamin A.


Cell locomotion, nerve elongation, and microfilaments.


An ultrastructural study of early myogenesis in the chick wing bud.


Erythropoiesis in the developing chick embryo.


Role of diffusible gradients in regeneration.


Vestigial DNA?

Vestigial DNA?


Metabolic controls in precancerous liver. IV. Loss of feedback control of cholesterol synthesis and impaired cholesterol uptake in ethionine-fed rats.


7S anti-tumour antibodies and activated Fc in macrophage tumour cell interaction.


Metabolic controls in precancerous liver. 3. Further studies on the control of lipid synthesis during N-2-fluorenylacetamide feeding.


The liver damaging effect of L-asparaginase--an experimental study of chronic toxicity.


The selective concentration of sulphadiazine and related compounds in malignant tissue.


Modification of dimethylnitrosamine-induced changes in renal metabolism and subsequent effect on carcinogenic activity of actinomycin D and cycloheximide.


Studies on the radiobiology of a rat sarcoma treated in situ and assayed in vitro.


Recent experience with bacteremia in patients presenting cancer.


Distributions of cell volume and DNA content of rhabdomyosarcoma cells growing in vitro and in vivo after irradiation.


Genetic factors and hormonal stimulation affecting weight and fertility of ewe lambs.


Some factors affecting pig survival.

Some factors affecting pig survival.


Reproduction in Targhee and Finnish landrace x Targhee ewes.


Effect of Mycoplasma hyopneumoniae infections, pyrantel treatment and protein nutrition on performance of pigs exposed to soil containing Ascaris suum ova.


Synchronization of estrus and ovulation in superovulated gilts.


Effect of preslaughter fasting on some chemical properties of bovine muscle and liver.


Body surface area of female swine.

Body surface area of female swine.


Cyclophosphamide (endoxan) metabolism in the rabbit: metabolic balance and elimination kinetics in different tissues and organs following oral administration.


On the presence of a ciliated columnar epithelial cell type within the bovine cervical mucosa.


Amino acid oxidation and plasma amino acid levels in sheep with abomasal infusions of graded amounts of lysine.


Bone magnesium, calcium and strontium concentrations in range cattle.


Chromic oxide and crude protein excretion in the bovine as influenced by water restriction.


Nutritional interrelationships of dietary calcium, phosphorus and magnesium in sheep.


An equation for prediction of energy expenditure of walking and running.


Effects of hypothermia on heart and respiratory responses of chicks to carbon monoxide.


Effect of plasma water loss on assessment of muscle metabolism during exercise.


Cardiac rate and ventilatory volume rate reactions to a muscle contraction in man.


Maternal and fetal responses to varying levels of oxygen intake in swine.


Topography of esophageal pressure in the dog.


Glycogen depletion pattern in human skeletal muscle fibers after heavy exercise.


Ventilatory response to alpha-adrenergic stimulation and inhibition.


Alactic O 2  debt and lactic acid production after exhausting exercise in man.


Effect of adrenergic stimulation and inhibition on human airways.


Energy balance during moderate exercise at altitude.


Cardiac output and total peripheral resistance changes during preavoidance periods in the dog.


Sustained human skin and muscle vasoconstriction with reduced baroreceptor activity.


Effects of hypoxia and physical training on hemodynamic adjustments to one-legged exercise.


Inhibition of lung cell division after hydrocortisone injection into fetal rabbits.


Cyclical variations in FRC and other respiratory variables in resting man.


Exercise and rat brain catecholamines.

Exercise and rat brain catecholamines.


Fluid filtration in the lung of the intact puppy.


Plasma electrolytes, pH, and ECG during and after exhaustive exercise.


Computer simulation of gas exchange in human lungs.


Compression atelectasis: a method for unilateral ventilation of the lung.


Assessment of Van Slyke manometric measurements of oxygen content.


A microelectrode resistance meter.

A microelectrode resistance meter.


Mass spectrometric study of the dynamics of gas transport through human skin to the lungs.


A practical apparatus for rapid determination of blood oxygen content.


Pulmonary ventilation and perfusion during graded pulmonary arterial occlusion.


A graded treadmill test for rats: maximal work performance in normal and anemic animals.


Energy requirements for intracapillary PCO 2  gradients.


Red cells and CO 2  gradients within pulmonary capillaries.


Cross-linked heparin binding of a membrane oxygenator system.


Intravascular radiopaque catheters in the dog: tissue reaction and possible lead loss.


Poly (ethyleneglycol methacrylate) as a material for hemodialysis.


Scanning electron microscopy of surfaces indicing shear hemolysis.


Biomechanical evaluation of bone-porous material interfaces.


Characterization of biomedical polymers.


Comments on "use of magnetostrictive transducers for stress measurements within methylmethacrylate 'bone cement'".


Reply to comments on "use of megnetostrictive transducers for stress measurements within methylmethacrylate 'bone cement'".


Functional characteristics of mast cells associated with rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene.


A murine renal cell carcinoma.

A murine renal cell carcinoma.


Ga-citrate and I-iododeoxyuridine as markers for in vivo evaluation of tumor cell metastasis and death.


Brief communication: polyene potentiation of antitumor agents.


Brief communication: metastases of human melanomas transplanted in "nude" mice.


Brief communication: ascorbic acid blocking of aminopyrine nitrosation in NZO-B1 mice.


Brief communication: feeding studies of nitrilotriacetic acid and derivatives in rats.


Brief communication: C-type particles in normal human placentas.


Brief communication: ultrastructural transformation of a murine Leydig-cell tumor after gonadotropin administration.


Leukemia irradiation studies.

Leukemia irradiation studies.


Antioxidants and cancer. I. Selenium in the blood of normals and cancer patients.


Glandular tumors of the nasal cavity induced by diethylnitrosamine in Syrian golden hamsters.


Alterations in DMBA-induced rat mammary tumors by actinomycin D.


Induction of carcinomas of the colon and rectum in rats by intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine.


Rauscher virus infection, erythrocyte clearance studies, and autoimmune phenomena.


Neural mechanisms underlying behavior in the locust Schistocerca gregaria. I. Physiology of identified motorneurons in the metathoracic ganglion.


Neural mechanisms underlying behavior in the locust Schistocerca gregaria. II. Integrative activity in metathoracic neurons.


Effects of gamma-hydroxybutyric acid and other hypnotics on glucose uptake in vivo and in vitro.


Identification of a calcium-binding, brain specific protein in the axoplasm of squid giant axons.


Enzymic activities in dissociated neurons differentiated in cultures in vitro.


Mass fragmentographic assay of homovanillic acid in brain tissue.


Interrelationships between polyamines and nucleic acids. Changes of polyamine and nucleic acid concentrations in the growing fish brain (Salmo irideus Gibb.).


Formation of GABA from putrescine in the brain of fish (Salmo irideus Gibb.).


Formation of putreanine, N-(4-aminobutyl)-3-aminopropionic acid from spermidine in rat brain and liver.


Transport of GABA from the perfused ventricular system of the cat.


The distribution and properties of the nonspecific N-methyltransferase in brain.


Effect of dexamethasone on phenylethanolamine N-methyltransferase in chromaffin tissue of the neonatal rat.


Distribution of serum proteins and beta-trace protein within the nervous system.


The postnatal development of catechol-O-methyl transferase in the rat brain.


The effect of development on the gangliosides of rat and pig brain.


Protein methylation by cerebral tissue.

Protein methylation by cerebral tissue.


Evidence for the synthesis and storage of 5-hydroxytryptamine in two separate pools in the brain.


Enzymatic desulphation of cerebroside-3-sulphate by chicken brain arylsulphatase A.


Low molecular weight constituents of cerebrospinal fluid: N-benzoylglycine (hippuric acid).


Tryptophyl-polypeptides in rat brain.

Tryptophyl-polypeptides in rat brain.


An improved solvent system for liquid scintillation counting in choline acetyltransferase activity assays by Fonnum's method.


Increase of brain tryptophan and stimulation of serotonin synthesis by salicylate.


Double labelling study of the spreading depression effect on the incorporation of labelled leucine into the proteins of the brain mitochondrial subfractions.


Effect of hypoxia on tyrosine and tryptophan hydroxylation in unanaesthetized rat brain.


Fetal heart monitoring during intrauterine transfusion.


Induction of labour by amniotomy and intravenous infusions of oxytocic drugs--a comparison between prostaglandins and oxytocin.


The management of abruptio placentae.

The management of abruptio placentae.


Evidence that fetal lung fluid and phospholipids pass into amniotic fluid in late human pregnancy.


The termination of pregnancy by intravenous infusion of a synthetic prostaglandin F 2   analogue. ICI 74 205, a synthetic analogue of prostaglandin F2 alpha (PGF2a) with an alkyl side chain extended by an ethyl group, was administered intravenously in 6 patients using normal saline as the vehicle.  Starting dose was 5 mcg/minute in the 1st case and 10 mcg/minute in subsequent cases.  Highest dose rate used in every case was 125 mcg/minute.  All, except 1 patient, were in the second trimester of pregnancy.  The other patient was in the first trimester of pregnancy.  Diarrhea and vomiting, as well as a local cutaneous inflammatory reaction at the site of intravenous infusion, occurred in all patients during the infusion but disappeared after the infusion had been stopped.  A fall in the plasma estradiol and progesterone levels was seen 2 hours after the start of the prostaglandin infusion.  Five patients had a complete abortion.  Abortion was incomplete in 1.  Mean induction-abortion interval was 25 hours 15 minutes, with a range of from 7 hours 45 minutes to 49 hours 30 minutes.  Although the results are encouraging, it is not possible to establish the effectiveness of ICI 74 205 because of the small series.  Further research should be done to determine whether the initial uterine activity is due to a direct effect of prostaglandin on the uterine smooth muscle or whether the final outcome depends on changes reflected by the fall in plasma estrogen and progesterone level.  Efficacy of ICI 74 205 in various dose regimens and other routes of administration should be investigated.


The value of a cervical score in the assessment of ovarian function.


The cytological diagnosis of endometrial pathology using a uterine aspiration technique.


Metaplasia in endocervical tissue maintained in organ culture--an experimental model.


A comparison of vacuum aspiration of the uterus and conventional curettage in the management of abnormal uterine bleeding.


Postmortem caesarean section. A case report.


Vagitus uterinus.

Vagitus uterinus.


Antenatal gonococcal arthritis.

Antenatal gonococcal arthritis.


Some aspects of the evolution and comparative anatomy of the human pelvis.


A role of the dietary lipid in the ability of phenobarbital to stimulate drug detoxification.


Proximal tubular rejection of sodium by furosemide.


Antidiuretic response to cyclophosphamide in man.


Enhancement by hemicholinium-3 of choline and acetylcholine excretion by the renal tubule of the chicken.


Inhibition of Ca   ++ transport into rat brain synaptosomes by diphenylhydantoin (DPH).


The transport and metabolism of salicylate in the central nervous system: in vivo studies.


Physiological disposition and metabolism of levo-methadone-1- 3 H in nontolerant and tolerant rats.


An investigation of pharmacologic and behavioral tolerance to morphine in rats.


Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration.


Effects of 6-hydroxydopamine treatments on active avoidance responding: evidence for involvement of brain dopamine.


Inhibition of norepinephrine- 3 H release from sympathetic nerve endings in veins by acetylcholine.


Auditory assembly of segmented sentences by children.


Effects of communication failure on speaker and listener behavior.


Hearing-impaired children's comprehension and production of syntax in oral language.


Relationship of lingual and intraoral air pressures during syllable production.


Release from multiple maskers in elderly persons.


Perceiving syllables and remembering phonemes.


Oral sensation and perception in apraxia of speech and aphasia.


Initial consonant intelligibility by hearing-impaired children.


Reflex contraction of middle-ear muscles secondary to stimulation of laryngeal nerves.


Deaf children's acquisition of the passive voice.


The effect of interposed conditions on the consistency of stuttering.


Acoustic characteristics of speech produced without oral sensation.


Esophageal cancer: results of therapy in an indigent population.


Pathologic changes in the human urinary tract due to anovulatory drug administration.


Transmission and emission scintiphotography of the heart and mediastinum.


Comparative effect of three nucleosides on suppression of cancer growth in mice.


Increasing the efficiency of cancer chemotherapy with heparin: "clinical study".


The pathophysiology and therapy of empyema in the isolated bladder.


Effect of syngeneic tumor tRNA on MOPC 315 myeloma in BALB-cCR mouse.


Extracellular clusters of spherical microparticles in glomeruli in human renal glomerular diseases.


Unilateral obstructive nephropathy in the rabbit. I. Early morphologic, physiologic, and histochemical changes.


Horseradish peroxidase tracer studies in the intestine in experimental cholera.


Glomerular sialic acid and proteinuria in human renal disease.


Acute duodenal ulcerations in the guinea pig due to fasting. Delineation of experimental model.


Cyclic neutropenia in grey collie dogs. Ultrastructural evidence for abnormal neutrophil granulopoiesis.


Pathology manpower needs in medical schools. A report by the ad hoc Committee on Manpower Needs in Pathology of the Committee on Pathology, Division of Medical Sciences, National Academy of Sciences-National Research Council.


Relicensure: by choice or by law?

Relicensure: by choice or by law?


Treatment of the potentially dysplastic dog.


Intestinal polyp in a dog.

Intestinal polyp in a dog.


Contracted tendons.

Contracted tendons.


Social attraction. The ultimate tool for canine behavior control.


Canine sarcoptic mange.

Canine sarcoptic mange.


An analysis of mechanism of the appearance of convulsions after intraventricular injection of eserine.


Effect of amantadine on cerebral acetylcholine release and content in the guinea pig.


The time course of noradrenaline decrease in rat spinal cord following transection.


Vagally mediated cardiac reflexes and their modulation by diazepam and pentobarbital.


Influence of naloxone and tolerance of citric acid cycle response to morphine and pain.


Inhibition of brain glutamate dehydrogenase by a metabolite of cycloheximide: its relevance for the ammonia formation of brain slices.


Anticonvulsant modification of tripelennamine effects on the electrographic activity of the cat brain.


Effect of probenecid on free 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and its sulphate in human cerebrospinal fluid.


Diffusion of oxygen in bacterial cells after exposure to high intensity pulsed electrons: theoretical model and comparison with experiment.


Correlation between animal and clinical findings with a psychotomimetic anticholinesterase.


Formation of excited states in the radiolysis of p-xylene.


Phenylation of nitrobenzene by gamma-radiation.


The effects of irradiation on human serum transferrin.


Exposure-response curve for radiation-induced lung tumors in the mouse.


Some pharmacologic effects of WR-2721: their role in toxicity and radioprotection.


Radiation effects on the hemolymph free amino acid pool of the honeybee prepupa (Apis mellifera) and the waxmoth larva (Galleria mellonella).


Effect of 2450-MHz microwaves on the radiation response of x-irradiated Chinese hamsters.


Comparison of the effectiveness of CaDTPA and ZnDTPA in removing  241 Am from the rat.


Nuclear-cytoplasmic relations in the mitosis of sea urchin eggs. IV. Modification of gamma-radiation-induced damage to sperm in whole eggs and in haploid and diploid half-eggs.


Human leptospirosis caused by serotype Alexi in Brazil.


Bladder-neck resection in multiple sclerosis. A uro-neurological study.


Cystectomy in cancer of the bladder. New surgical precedure.


Hormonal changes in urine and plasma in patients with various testicular tumours before and after treatment. I. Seminoma.


Hormonal changes in urine and plasma in patients with various testicular tumours before and after treatment. II. Malignant teratoma of intermediate type B and malignant trophoblastic teratoma.


Spontaneous passage of large calculi from true and false ureteroceles.


Urinary zinc excretion in patients with urolithiasis.


Case report. Tibial resonant frequency in Paget's disease.


The drug abuse program at the Milwaukee County institutions--after two years.


Cancer registries and their usefulness in Wisconsin.


Epidural "blood patch" for the treatment of post spinal puncture headaches.


Current status of oral contraceptives.

Current status of oral contraceptives.


The impact of radioimmunoassay for hepatitis B antigen on blood banking and transfusion practices in Wisconsin.


Standards and guidelines for a radiotherapy network in Wisconsin.


Response of the vagina of newborn rats to sequential treatment with sexual hormones.


A study of some of the histological and histochemical features of the zona reticularis.


Kidney vascular supply in the rat, cat and dog.


Ultrastructure of Peyer's patches in the aged mouse.


Points of glandular secretion in the nasal cavity of mice.


Correlative histochemical and ultrastructural observations on the mitochondria of ram spermiogenesis.


A note on lymphoid aggregations in the oesophagus of the frog (Rana cancrivora).


A possible morphological basis for pearl necklace arteries.


The rootlets of the trochlear nerve. Anatomical observations in human brains.


Behavioral consequences of increased phenylalanine intake by phenylketonuric children: a pilot study describing a methodology.


Some perspectives on research in mental retardation research centers.


Decoding as a result of synthetic and analytic presentation for retarded and nonretarded children.


Presciptive screening for inborn errors of metabolism: a critique.


Conjugate control of motor activity in mentally retarded persons.


Effects of concept familiarization vs. stimulus enhancement on verbal abstracting in institutionalized retarded delinquent boys.


Receptive vocabulary: performances and selection strategies of delayed and nondelayed toddlers.


Partial trisomy of chromosome number 15 identified by trypsin-Giemsa banding.


"Superstition": the effects of independent and contingent events on free operant responses in retarded children.


Intellectual development and the role of salience n intentional and incidental recall.


Chromosome survey of moderately to profoundly retarded patients.


School performance of children who were severely malnourished in infancy.


On the theory and practice of improving short-term memory.


Rehearsal processes in the short-term memory performance of mildly retarded adolescents.


The dysfunctional and the neoplastic: clinical investigation in the service of patient care in endometrial cancer.


Germ-free delivery. The initiation of management of infants with a high probability of congenital immune deficiency states.


Combined surgical and radiation treatment of invasive carcinoma of the cervix.


Leukoplakia of the cervix.

Leukoplakia of the cervix.


Factor influencing survival in Stage I ovarian cancer.


Factors contributing to improved maternal care and fetal outcome in a medium-sized city-county hospital.


The gentle art of external cephalic version.


Coagulation changes in saline-induced abortion.


The induction of abortion and menstruation by the intravaginal administration of prostaglandin F 2a . The efficacy of intravaginal administration of prostaglandin F2 alpha (PGF2alpha) in induction of abortion was determined in a clinical trial of 16 gravidas aged 21-38, parity 0-4, between the 6th-11th weeks of pregnancy.  PGF2alpha tablet (50 mg) was inserted into the posterior fornix of the vagina and repeated at 1-2 hour intervals; dose range varied from 50-250 mg.  Slight to severe labor-like pain was felt by all patients in the lower abdominal region 20 minutes-4 hours after PGF2alpha administration.  Vaginal bleeding occurred within 30 minutes-8 hours.  In all but 1 case, the fetus and the villi were expelled broken into small pieces.  All 16 patients aborted, 7 completely and 9 incompletely.  This form of administration is deemed efficacious as 3 patients aborted completely within 5 hours and 4 aborted completely between 15-18 hours.  Bleeding in most cases occurred following the onset of abdominal pain, 30 minutes-8 hours after treatment.  In another clinical trial, the efficacy of intravaginal administration of PGF2alpha in inducing menstruation was tested in 10 volunteers aged 31-40.  Either 50 or 25 mg PGF2alpha tablets were used.  The patients recorded their basal body temperature (BBT) every morning.  Menstruation was successfully induced in 6 of 10 patients.  6 patients treated 2-3 days before the expected date of menstruation had menstrual-like bleeding 1-9 hours after PGF2alpha administration.  3 patients treated 5, 7, and 13 days (a day before BBT shift) before the expected date of menstruation did not have vaginal bleeding.  1 patient, with monophasic BBT who was treated 3 days before the expected menstruation, did not have menstrual bleeding.  Amount of induced flow was more or less the same in most patients; duration of flow was normal in all cases.  The mechanism of action of PG in menstruation induction is not known.  The authors speculate that PGF2alpha mechanically stimulates separation of the superficial endometrium from the remainder of the uterine wall when the endometrium is in the premenstrual state.  Side effects noted were nausea, diarrhea, pyrexia, slight flushing of the face, and headache.


Malignant fibroxanthoma: a sarcoma of the vulva.


Lecithin-sphingomyelin ratio changes with estrogen or glucocorticoid treatment.


Age at menarch, family size, and birth order.


The Karman catheter.

The Karman catheter. A letter is written in response to a report by Drs. Beric, Kupresanin, and Hulka (Am. J, Obslet Gynecol. 114: 273, 1972) which stated that the Karman catheter is not suitable for terminating pregnancies beyond Week 6 of pregnancy.  The use of a Karman catheter in terminating pregnancies of 7-10 weeks resulted in 47% to 100% retention of products.  The writer states that he used a 6 mm Karman-type catheter only for pregnancies up to 70 days' gestation and an 8 mm size for pregnancies from 70 to 85 day's gestation.  In 120 patients who underwent the procedure, only 1 had possible uterine sepsis.  Although 75% had small vaginal bleeding during the first week, none had bleeding after the next menstruation.  The writer believes that Dr. Beric and his associates were right in drawing attention to the problem of residue, but notes that this was not a problem in his series.


On the fetal heart rate in early pregnancy.


The current confusion over homosexuality.


Prophylactic psychotherapy with children.


Future oriented psychotherapy as a prophylactic gerontologic procedure.


Three important factors in psychotherapy with criminal patients.


Values and the psychology of the superego.


Toward a cybernetic model of group therapy.


Klismaphilia: enema as a sexual preference. Report of two cases.


Expressive nonverbal behavior in psychotherapy.


A structural approach to patient and therapist disengagement from a schizophrenic family.


Superior mesenteric artery syndrome in children.


Plain film skull roentgenographic changes in hydrocephalus.


Evaluation of the changes of cerebrospinal fluid movement associated with meningitis: a cisternographic analysis.


Cystic teratomas of the ovary in pregnancy.


Roentgen evaluation of the paranasal sinuses in children.


Microangiography of human fetal spinal cord.


Hydrometrocolpos in infancy.

Hydrometrocolpos in infancy.


Congenital multiple fibromatosis. A case report with review of the world literature.


Roentgenologic features of dermatomyositis of childhood.


Roentgenographic visualization of the umbilical arteries in pneumoperitoneum in the newborn.


Hemosiderin laden lymph nodes. An unusual roentgenographic manifestation of homozygous thalassemia.


Roentgenographic findings of complications with neonatal umbilical vascular catheterization.


A technique for correlating the roentgenologic appearance of infant lung to its anatomy.


Congenital microgastria.

Congenital microgastria.


Caustic damage of the gastrointestinal tract: roentgen features.


Use of barium in the diagnosis of appendicitis in children.


Volvulus of the sigmoid colon.

Volvulus of the sigmoid colon.


Pancreatic ascites: diagnosis and management with particular reference to surgical technics.


Effect of hiatus hernia repair and truncal vagotomy on human lower esophageal sphincter pressures.


Retroanastomotic hernias after gastrojejunal anastomoses.


Gastroesophageal reflux: diagnosis and treatment.


Stroke associated with elongation and kinking of the carotid artery: long-term follow-up.


Peritoneal drainage versus non-drainage for generalized peritonitis from ruptured appendicitis in children: a prospective study.


Mammographic examinations (4030): ten-year clinical experience in a community medical center.


Cancer of the breast: an analysis of the 222 non-survivors in our personal series.


Bacteroides infections.

Bacteroides infections.


Reactions of a water soluble cobalt porphyrin with thiocyanate.


Exchange of oxygen between solvent H 2 O and the CO 2  produced in Cypridina bioluminescence.


A rapid and simple method for the purification of rat liver RNase inhibitor.


Orientation of chlorophyll in vivo. Studies with magnetic field oriented chlorella.


Differential effects of cycloheximide on protein and RNA synthesis as a function of dose.


The involvement of histidine in the action of liver carboxylesterases.


Effect of polyhydric alcohols on kinetic parameters of enzymes.


Isolation of active messenger RNA for   s  casein from bound polyribosomes of mammary gland.


Enhancement of the fluorescence intensity of dansyl amino acids in aqueous media and its application to assay of amino acids.


Changes in the phosphorylation of non-histone chromatin proteins during the cell cycle of HeLa S 3  cells.


Dimorphism of Cancer magister hemocyanin subunits.


Incorporation of  18 O into homovanillic acid of rat brain during exposure to oxygen 18 containing atmospheres.


Collagen crosslinks: occurrence in basement membrane collagens.


Isolation and characterization of an hydroxykynureninase from homogenates of adult mouse liver.


Enzymatic demethylation of calf thymus histones.


The cardiorespiratory effects of halothane, trichloroethylene and nitrous oxide in the dog.


Erythrocyte osmotic fragility in hyperthermia-susceptible swine.


Determination of bromides in blood by neutron activation analysis.


Significance of the individual components of the Apgar score.


Observations during endobronchial anesthesia I: ventilation and carbon dioxide clearance.


The effect of althesin on intracranial pressure in man.


A comparison of jugular and central venous pressure measurements during anaesthesia.


Rise in serum creatine phosphokinase associated with agents used in anaesthesia.


Effects of althesin on cerebrospinal fluid pressure.


Intravenous diazepam in dentistry: monitoring results from a controlled clinical trial.


An intravenous method of anaesthesia for Caesarean section. II. Ketamine.


Tests of recovery from anaesthesia and sedation: intravenous diazepam in dentistry.


Performance of the Quantiflex monitored dial mixer.


Pneumothorax and contralateral hydrothorax following subclavian vein catheterization.


Denervation supersensitivity: the response to depolarizing muscle relaxants.


Clinical significance of the nerve stimulator in emergency Caesarean sections. A preliminary communication.


Malignant hyperpyrexia in a Negro.

Malignant hyperpyrexia in a Negro.


Pre-stretched cuffs on tracheostomy tubes.


Methoxyflurane in Caesarean section.

Methoxyflurane in Caesarean section.


Simple and reliable methods of inserting a nasogastric tube during anaesthesia.


Radiocytogenetic effects on bone marrow cells of opossum in vivo.


Chromosome evolution: repetitive euchromatic chromosomal segments in Hawaiian Drosophila.


Constitutive heterochromatin in mouse chromosomes treated with typsin.


Drowning and the diving reflex.

Drowning and the diving reflex.


Halifax drug abuse.

Halifax drug abuse.


British Columbia Medical Association.

British Columbia Medical Association.


Psychiatric problems in the aged.

Psychiatric problems in the aged.


Frequency of hepatitis B antigen.

Frequency of hepatitis B antigen.


Early breast cancer.

Early breast cancer.


Enrolment of out-of-province medical students.


Research in Indian medicine.

Research in Indian medicine.


Does continuing medical education by peer review really work? A peer review of breast operation statistics was conducted. Standards for the proportion of biopsies positive for cancer, and for length of postoperative stay following operation for benign and malignant conditions were developed and each surgeon was informed of his performance and how it compared with that of his colleagues. The same parameters of care were reviewed one year later to study changes in performance. Low volume of clinical material, failure of two surgeons to change, and a steady general improvement in all parameters in the years prior to the presentation of the peer review, confused the demonstration of improvement in the year after the educational effort. There was a statistically significant improvement in the proportion of biopsies positive for cancer, reflecting reduction in unnecessary biopsies, but the pre-existing annual improvement in reducing postoperative stays was not accelerated. Does continuing medical education by peer review really work? Probably.


Treatment of streptococcal pharyngitis. I. Clinical evaluation. A study was undertaken to evaluate the therapy of streptococcal pharyngitis. The compliance of 118 patients with beta-hemolytic streptococcal pharyngitis to follow-up was 72%. Of 74 patients checked by means of urine tests 66 took their oral medication. No differences were detected in the clinical and bacteriological results (>98% streptococcal eradication) after the 7th or 10th day of therapy after taking either cephalexin or penicillin.IT WAS CONCLUDED THAT: (a) for effective surveillance and follow-up special attention should be given to the uncooperative segment of the patient population; (b) a seven-day course of penicillin may be satisfactory in the eradication of BHS from the throat; and (c) cephalexin appears to be an effective alternative to penicillin for the treatment of streptococcal pharyngitis.


Evaluation of on-campus continuing medical education programs in Alberta. Seven on-campus continuing medical education programs offered during the 1971-72 academic year were evaluated. A multiple-choice examination was taken by the participants before each course; the same examination was administered immediately after the course was completed, and a third examination was taken three to five months later. It was found that for each course there was a significant increase in knowledge at both post-testing periods. A questionnaire developed for the purpose of determining the effectiveness of the courses was also administered at the time of the third test, and exhibited reasonable degrees of reliability and validity. A large proportion of the participants indicated the content of their courses was relevant and necessary, and was being used in their medical practice. It was concluded that the effectiveness of these programs justified their continuation.


Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.


AK lymphoma model.

AK lymphoma model.


Chemotherapeutic effects of compound 593A (NSC-135758) on mouse leukemias and some transplanted animal tumors.


In vitro and in vivo cytogenetic effects of 3-(bis(2-chloroethyl)amino)-4-methylbenzoic acid (NSC-146171; IOB 82) in human peripheral leukocytes.


Report of vascilitis and blindness after intracarotid injection of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in dogs.


Increased immunogenicity of murine lymphatic tumors by pyrazole-4-carboxamide, 3(or 5)-amino (NSC-1402; PCA).


Studies on the effect of tumor type and route of administration on the antitumor activity of the amino acid mimosine (NSC-69188).


Further clinical studies of 5-fluorouracil (5-FU; NSC-19893) given by the multiple daily dose method in disseminated breast cancer.


Clinical evaluation of hexamethylmelamine (NSC-13875).


Effective treatment of Kaposi's sarcoma with 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388).


Comparison of two dose schedules of dichloromethotrexate (NSC-29630) in lung cancer.


Study of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) in patients with disseminated melanoma.


Estradiol mustard (NSC-112259)--clinical brochure.


The conversion of the pyrrolizidine alkaloid retrorsine to pyrrolic derivatives in vivo and in vitro and its acute toxicity to various animal species.


The effects of aflatoxin B 1  and aminoazodye carcinogens on rat and mouse liver nuclear acid deoxyribonuclease.


Cytochrome P-450 difference spectra of microsomes from several insecticide-resistant and -susceptible strains of the housefly, Musca domestica L.


Biochemical changes in mouse liver after palmitoyl-ethanolamide (PEA) administration.


Pesticide-induced changes in hepatic microsomal enzyme systems. Some effects of 1,1-di(p-chlorophenyl)-2,2-dichloroethylene (DDE) and 1,1-di(p-chlorophenyl)-2-chloroethylene (DDMU) in the rat and Japanese quail.


Decrease of acid-stable ribonuclease activity of rat liver homogenate and isolated ribosomes after phenobarbital administration.


Kinetics of calcium oxalate deposition in vitro.


Keratoacanthoma of nailbed: a report of two cases.


Antiandrogen effects on canine prostatic secretion.


Effect of diethylstilbestrol on blood glucose of prostatic cancer patients.


Disseminated superficial actinic porokeratosis (DSAP).


Glycogen accumulation in neurogenic bladder muscle. A reappraisal.


The effects of isoproterenol and aminophylline on detrusor muscle contractility in an organ bath apparatus.


Pellagra: notes and comments.

Pellagra: notes and comments.


Ascending pyelonephritis in dogs induced by ureteral dysfunction.


Magnetically induced detrusor contraction. A new concept for treatment of neurogenic bladder.


Spectral wavelength, light and electron microscope studies in xeroderma pigmentosum.


The influence of trigonectomy on vesicoureteral reflux in dogs.


Ureteral wall tension. A new means of evaluating ureteral function.


Leucine-isoleucine interrelationship in the young pig.


Chronic blood pressure measurement in the rat with a silastic aortic cannula.


Reevaluation of the isoleucine requirement of the young pig.


Tolnaftate as a prophylactic agent for tinea pedis.


Zeranol and dietary protein level effects on live performance, carcass merit, certain endocrine factors and blood metabolite levels of steers.


Cutaneous sporotrichosis: report of two cases in suburban Long Island, New York.


Zeranol and dietary protein level effects on DNA, RNA and protein composition of three muscles and the relationship to serum insulin and GH levels of steers.


Pituitary and gonadal hormones associated with fertile and nonfertile inseminations at synchronized and control estrus.


Early pregnancy diagnosis based upon plasma progesterone levels in the cow and ewe.


Insulin turnover and irreversible loss rate in horses.


Effects of early weaning on postpartum reproduction of cows.


Difficulties associated with the use of tritiated polyethylene glycol as a water-soluble digestion marker in ruminants.


TS-A 2 , TS-B, R-, and S-caseins: their isolation, composition, and relationship to the  - and  -casein polymorphs A 2  and B.


Range behavior of Hereford, Hereford x Holstein and Holstein non-lactating heifers.


Enzymic changes in bovine adipose and mammary tissue, serum and mammary tissue hormonal changes with initiation of lactation.


Effect of growth hormone on milk production and feed utilization in dairy cows.


Environmental heat and partial water restriction effects on body fluid spaces, water loss, body temperature, and metabolism of Holstein cows.


Postpartum estrus as an indicator of reproductive status in the dairy cow.