Isolation and partial characterization of a mycotoxin from Penicillium roqueforti. Extracts of pure cultures of Penicillium roqueforti isolated from toxic feed samples and of P. roqueforti NRRL 849 were lethal to rats by either intraperitoneal or oral administration. Purification studies guided by this test led to the isolation of a major toxin which showed intraperitoneal and oral median lethal dose values in weanling rats of 11 and 115 mg/kg, respectively. Partial characterization of the crystalline compound, C(17)H(20)O(6), by infrared, ultra violet, PMR, and mass spectroscopy, and by several chemical transformations indicated the presence of three C-methyl substituents plus one acetoxy, one aldehyde, and one alpha,beta-unsaturated ketone group. Two oxygen atoms are present either in epoxide or ether form.


Technical factors affecting an immunoelectrophoretic reference system for analysis of mycobacterial antigens. The length of immunoelectrophoretic separation patterns obtained with a reference mycobacterial antigen was reduced significantly when a continuous buffer system was used in place of the recommended discontinuous system. Varying the supporting medium by using 1% concentrations of different agar preparations in the discontinuous system also affected the separation length and resolution of the reference pattern. Measurement of the electrical resistivity of the agar medium provided an explanation of these differences on the basis of current density or field intensity applied per slide. Variation in the reference pattern obtained in differently designed electrophoresis chambers also was attributed to differences in field intensity. To avoid these obvious alterations in the separation pattern of the reference antigen, it was suggested that separation procedures described originally for the reference system be used without modification.


Edwardsiella tarda, a new pathogen of channel catfish (Ictalurus punctatus). Edwardsiella tarda, an enteric, gram-negative bacterium, causes gas-filled, malodorous lesions in muscle tissue of channel catfish. Incidence and epizootiology of the disease are presented.


An inexpensive indicator for measuring animal temperatures by radio telemetry.


Competitive inhibition for amino acid uptake by the indigenous microflora of Upper Klamath Lake. The uptake of a specific (14)C-amino acid by the heterotrophic microorganisms in the epilimnion of an eutrophic lake was influenced by the presence of other amino acids. The effect of unlabeled serine on (14)C-glycine uptake was shown to be caused by competitive inhibition, which changed the interpretation of the kinetic parameters, the turnover time, T(t), and the sum of a transport constant, (K(t) + (S(n)), and the natural substrate concentration. The maximum velocity of uptake, V(max), is unaffected by the competitive inhibition.


Agglutinin response of pigs to intranasal infection of Bordetella bronchiseptica.


Transposition of the aorta and atresia of the pulmonary trunk in a horse.


Serum electrolyte concentrations, as a function of age, in female dairy cattle.


Hematologic parameters, as a function of age, in female dairy cattle. Aging and hematologic values.


The first report of lumbar paralysis in sheep due to nematode larvae infestation in Iran.


Metabolic and ultrastructural studies on articular cartilage of developing canine hip joints.


Nitrogen utilization in cattle using a nitrogen depletion-repletion technique.


Influence of manganese intake on metabolism of manganese and other minerals in sheep.


Interval urea infusion for lambs.

Interval urea infusion for lambs.


Amino acid and fatty acid composition of bovine ruminal bacteria and protozoa.


Changes in RNA species during differentiation of fiber types in skeletal muscle.


Some effects of unilateral ovariectomy in the postpartum beef cow.


LH, prolactin, estradiol and progesterone in bovine blood serum during early pregnancy.


Thyroidal iodine metabolism and uterine-ovarian characteristics of rats and swine treated with methallibure or its metabolites.


Postpartum changes in nitrogenous constituents of sow milk.


Effects of injections of a norethandrolone suspension of synchronization of estrus and conception in beef cattle.


Polymorphisms in caseins of sheep milk.

Polymorphisms in caseins of sheep milk.


Techniques for rearing cesarean section derived colostrum free piglets.


Developmental changes in the nonheme iron composition of the liver and spleen in piglets.


Utilization of different forms of dietary selenium.


Efficiency of tryptophan as a niacin precursor in the young chick.


Tryptophan requirement of growing pigs at three levels of dietary protein.


Effect of dietary energy concentration on sulfur amino acid requirements and body composition of young chicks.


Effects of dilution and glycerol on the release of glutamic-oxaloacetic transaminase (GOT) from boar spermatozoa.


Determining fetal numbers in pregnant ewes.


Effects of sexual preparation on sperm output, semen characteristics and sexual activity of beef bulls with a comparison to dairy bulls.


Plasma corticosteroids in Hereford bulls exposed to high ambient temperature.


Evaluation of carboxymethylcellulose as an injectable carrier for follicle stimulating hormone.


Influence of nursing intervals on changes in serum proteins (immunoglobulins) in neonatal pigs.


Bovine serum estrogens, progestins and glucocorticoids during late pregnancy parturition and early lactation.


Tissue  203 Hg distribution in young Holstein calves after single tracer oral doses in organic and inorganic forms.


Blood volume determination in the mouse. 1. The blood volume of the mouse has been measured using (59)Fe-labelled red cells to determine the red cell volume and (131)I-labelled human serum albumin to determine the plasma volume.2. Values for the blood volume of 95.0 +/- 1.5, 96.3 +/- 2.7 and 84.7 +/- 1.2 ml./kg body wt. were found for CSI female, CBA female and CBA male mice respectively.3. A marked discrepancy was observed between the venous (cardiac) haematocrit and the whole body haematocrit.4. The blood volume of the mouse must be determined from the red cell volume and the plasma volume, measured using appropriate labels, and not from the red cell volume or the plasma volume using the venous haematocrit.


The contractile properties of human motor units during voluntary isometric contractions. 1. The electrical activity of single motor units has been recorded from the first dorsal interosseus muscle of normal human subjects during voluntary, isometric contractions, together with the force generated by the muscle.2. By averaging the force correlated with the impulses from a single motor unit, the contraction time and twitch tension generated by that motor unit could be measured. When the rate of discharge was limited, either voluntarily or by automatic selection of intervals for analysis, the time for the tension to decline to half its maximum value (half-relaxation time) could also be measured for some motor units.3. Under our experimental conditions the trains of impulses from different motor units in most subjects were generated quite independently as tested by (a) measuring the correlation between activity in single units and that in the whole muscle as recorded by the surface electromyogram (e.m.g.), (b) measuring the cross-correlations between pairs of single units and (c) comparing the tension generated by stimulating single motor units with the average tension correlated in time with voluntary activity of single units in the same location.4. In one normal subject evidence of synchronization between separate motor units was obtained. Cross-correlation studies suggested that the cause of the synchronization was the presence of substantial common excitation received by the various motor units in the muscle.5. The frequency response for the contractions of single motor units was well fitted by that for a linear, second-order system with nearly critical damping. However, when stimulation of a few motor units was superimposed on a voluntary contraction, underdamped (oscillatory) responses were seen which were probably of reflex origin.6. The significance of these results in relation to the normal postural tremor in hand muscles is discussed.


Sensory inputs to neurones in Clarke's column from muscle, cutaneous and joint receptors. 1. Discharge of neurones at the region of Clarke's column of the cat was recorded intracellularly or extracellularly in response to electrical stimulation of various hind limb nerves or to adequate stimuli applied to a variety of sensory receptors.2. According to the type of excitatory sensory input, the neurones were classified into four groups. Their relative proportions were: muscle group, 55-65%; cutaneous group, 15-25%; joint group, 5-15%; convergent group, 10-20%.3. The location of the neurone cell bodies was examined by marking the site of extracellular recording with fast green. The neurones of the muscle or cutaneous group were found to be within Clarke's column. One out of four neurones tested for the joint group and two out of six cells examined for the convergent group were found to be located outside the column.4. There was no difference in axonal conduction velocity among the neurones of different groups.5. The neurones of different groups could be distinguished in terms of the pattern of discharges recorded under ;resting' conditions and during activation of sensory receptors. It is suggested that information carried by dorsal spinocerebellar tract neurones to the cerebellum has a lower signal-to-noise ratio for cutaneous inputs than for muscle or joint inputs.


Somatotopic organization of vibrissal responses in the ventro-basal complex of the rat thalamus. 1. The region of the ventro-basal complex (VB) of the thalamus responding to movements of the whiskers has been mapped electrophysiologically in rats under either urethane or barbiturate anaesthesia.2. Whisker responses were found in the dorso-medial part of VB throughout its rostro-caudal extent; they occupied one third to one half of the total VB region.3. Most cells responded to movements of only one whisker and the responses were somatotopically organized. The different horizontal lines of whiskers were represented at different rostro-caudal levels within the nucleus, the most dorsal line being represented most caudally. At each level the larger, more caudal whiskers were represented more dorsally and laterally than the smaller, more rostral whiskers.


The responses of cells in the rat thalamus to mechanical movements of the whiskers. 1. The responses of single cells to mechanical movements of individual whiskers have been recorded from the ventro-basal complex of the thalamus, in rats under urethane or barbiturate anaesthesia.2. With ramp-shaped displacements of a whisker above a critical velocity, the cells gave a short latency response of 1-5 impulses, while with sinusoidal movement (1-35 Hz) they usually responded with 1-2 impulses per cycle.3. The cells did not respond to maintained deflexions of a whisker. Small static displacements did not modify the response to a superimposed movement; larger static displacements reduced or abolished the response.4. Three-quarters of the cells were found to be particularly sensitive to movements in one quadrant (90 degrees or less). For any one cell, there was no obvious relationship between the most sensitive direction and the position of the whisker on the face.5. The ramp amplitude appeared to have little effect on the response. However, increases in ramp velocity decreased the response latency and, in some cells, increased the number of impulses per ramp.6. Other studies have shown that most afferent nerve fibres from whiskers give slowly adapting responses and the possible modification of these thalamic responses, by anaesthesia, is discussed.


The effect of chronic duct ligation on the vascular and secretory responses of the cat's submaxillary gland. 1. The object of the present experiments was to re-investigate the role of kallikrein in functional hyperaemia in the submaxillary gland of the cat. Kallikrein concentration in the gland and saliva was reduced by ligation of the duct for 2-3 days before the acute experiment, at which time the duct was cannulated proximal to the ligation and blood flow and salivation measured.2. Despite the fall in kallikrein concentration, a normal two-phase vascular response was obtained on continuous stimulation of the chorda-lingual nerve at 1-5 Hz and the progressive increase in blood flow to a constant level characteristic of 10 and 20 Hz stimulation was also seen. Quantitatively, the increase in blood flow following a 10 sec stimulation was reduced to about 75% of control values at all stimulation frequencies used and the maintained vasodilatation was reduced when using continuous stimulation at 1 Hz but not at 10 and 20 Hz.3. The supersensitivity to the vasodilator properties of bradykinin, previously reported to follow duct ligation, was confirmed.4. The increased blood flow produced by chorda-lingual nerve stimulation could be delayed by circulatory arrest. Evidence was obtained suggesting that the vascular response to chorda stimulation delayed by arterial occlusion was not mediated by kallikrein alone.5. It was concluded that kallikrein was not the sole mediator of functional hyperaemia in the cat submaxillary gland but that a combination of vasodilator nerves and kallikrein release explained more phenomena than either hypothesis alone.


Methallibure-induced congenital abnormalities in the pig: an example of drug teratogenicity in farm animals.


A technique for intra-cystic injections in the treatment of cystic ovarian disease in bovine animals.


Reproductive performance of Kerry cattle inseminated with Charolais semen.


Problems associated with ovum transplants.


Brucellosis--progress and problems (Great Britain).


Brucellosis--progress and problems (Republic of Ireland).


Brucellosis--a clinician's viewpoint.

Brucellosis--a clinician's viewpoint.


Ataxia of the Great Dane caused by stenosis of the cervical vertebral canal: comparison with similar conditions in the Basset Hound, Doberman Pinscher, Ridgeback and the thoroughbred horse.


Summarised observations on the ultrasonic detection of pregnancy and foetal life in the mare.


Canine vaccination and distemper.

Canine vaccination and distemper.


Progress on the use of frozen semen in the dog.


Serum cholesterol esterification in patients with coronary heart disease. Importance of initial rate of esterification expressed as a function of free cholesterol.


Ischemic myocardial injury during cardiopulmonary bypass surgery.


Complete heart block in acute myocardial infarction: drug therapy.


A method of permanent transvenous implantation of an atrial electrode.


The electrophysiologic demonstration of atrial ectopic tachycardia in man.


Sick people's food.

Sick people's food.


Functional characteristics of the Wolff-Parkinson-White bypass. A study of six patients with His bundle electrograms.


The effects of massive doses of methylprednisolone on myocardial contractility and peripheral vascular resistance.


Footballer's migraine.

Footballer's migraine.


Dopamine in experimental myocardial infarction.


Accurate Valsalva maneuver made actually easy.


Metabolism of organophosphorus insecticides. XII. Degradation of  32 P-malathion in the adult larva of the cotton leaf worm.


Kinetics of serotonin accumulation into synaptosomes of rat brain--effects of amphetamine and chloroamphetamines.


The action of ATP in the guinea-pig heart.


The potentiation of the action of adenosine on the guinea-pig heart.


Effects of pyrazole and 3-amino-1,2,4-triazole on methanol and ethanol metabolism by the rat.


Inhibition of heterolysosome formation and function in mouse kidneys by injection of mercuric chloride.


Blood levels of  3 H-  9 -tetrahydrocannabinol and its metabolites in tolerant and nontolerant pigeons.


3,4-Dihydroxyphenylalanine (dopa), dopamine and norepinephrine storage in the rat heart after L-dopa--further evidence for norepinephrine release.


Influence of different anions on catecholamine release induced by tyramine and amphetamine.


Distribution of radioactivity in brain of tolerant and nontolerant pigeons treated with  3 H-  9 -tetrahydrocannabinol.


Effect of dietary lipid ingestion on the induction of drug-metabolizing enzymes by phenobarbital.


Electric permittivity of alfalfa mosaic virus in aqueous solutions.


Theoretical model for the equilibrium behavior of DNA superhelices.


The extrinsic Cotton effects of nitrobenzylic chromophore bound to helical poly- ,L-glutamic acid.


Interaction of the polyelectrolyte heparin with copper(II) and calcium.


Study of dielectric behavior of DNA in shear gradient.


Conformational analysis of an ionizable polydipeptide.


Intrachain hydrolysis in sarcosine-- -p-nitrophenyl-L-glutamate copolymers.


The conformational characteristics in solution of the synthetic cyclic hexapeptide 5L-ala-D-ala.


Interactions of metallic ions with DNA. V. DNA renaturation mechanism in the presence of Cu 2+ .


Origins of the differences between the circular dichroism of DNA and RNA: theoretical calculations.


Flexibility of tropocollagen from sedimentation and viscosity.


Ultrasonic absorption studies of poly-benzyl-L-aspartate in mixed solvents, in relation to the helix-cell transition.


Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism.


The relationship of analgesia to general anesthesia with nitrous oxide.


A review of normal inter-metatarsal angles.


Angular metatarsal osteotomy. A preliminary report.


Pyogenic granuloma. A case report.

Pyogenic granuloma. A case report.


Mild hypothyroidism and its effects on the larynx.


Hyperkeratosis of the larynx.

Hyperkeratosis of the larynx.


Cartilaginous tumours of the head and neck.


The place of septal replacement operation in treatment of nasal obstruction.


Ulceration in ectopic mucosa of the esophagus.


Lateral nasal proboscis.

Lateral nasal proboscis.


Stevens-Johnson syndrome associated with mycoplasma pneumoniae infection.


An unusual complication during adeno-tonsillectomy.


Lipoid proteinosis of the larynx.

Lipoid proteinosis of the larynx.


Septoplasty.

Septoplasty.


Tympanosclerosis.

Tympanosclerosis.


Health access stations.

Health access stations.


The effect of an iminostilbene derivative (G32883) on peripheral nerves.


Continuing medical education on cancer in Georgia.


Management of angina: long-acting coronary vasodilators.


Liquidity of unregistered investments.

Liquidity of unregistered investments.


Radiologic seminar. CXXIV. Gonadal dysgenesis.


"A plea for comprehensive health planning".


The emergency department physician: an emerging specialty.


Observations on acupuncture and reimplantation surgery in the People's Republic of China.


Observations on some medical procedures in the People's Republic of China.


Traditional medicine in the People's Republic of China.


The organization and delivery of health services in the People's Republic of China.


Community health and consumer participation in the health care delivery system, PRC.


Status of women in China--maternal and child care.


Socio-politico-cultural aspects, PRC.

Socio-politico-cultural aspects, PRC.


Chinese cosmogony and Yang-Yin theory.

Chinese cosmogony and Yang-Yin theory.


China: a medical student's viewpoint.

China: a medical student's viewpoint.


The National Medical Association Delegation's visit to the People's Republic of China.


Acupuncture in general practice.

Acupuncture in general practice.


Hyperlipoproteinemias and xanthomatosis.


Comparative study of Gantanol in serum and prostatic tissue.


Spontaneous perforations of the stomach in the newborn.


Twin pregnancy in a uterus didelphys delivered by bilateral repeat cesarean sections.


The continuing impact of infections in surgical practice.


Alcohol block of the mandibular nerve. Report of a complication.


Hyperactivity in children.

Hyperactivity in children.


Duodenal stump problems.

Duodenal stump problems.


Medical education in the People's Republic of China.


Radiotherapy for keloid treatment.

Radiotherapy for keloid treatment.


Effects of anoxia in vitro on cellular respiration of brain cortex.


Studies on S-adenosylhomocysteine inhibition of histamine transmethylation in brain.


Circular dichroism of nerve membrane fractions: effects of temperature, pH and electrolytes.


Biochemical studies of myelin in Wallerian degeneration of rat optic nerve.


Accelerated efflux of ( 14 C) and ( 3 H) amino acids from superfused slices of rat brain.


The determination of picomole amounts of acetylcholine in mammalian brain.


The influence of ionic strength on the interaction of quaternary drugs with mammalian acetylcholinesterase in relation to possible regulatory effects.


The arabinose content of cerebral and vitreous humour hyaluronate-peptide.


Effects of food deprivation and immobilization on tryptophan and other amino acids in rat brain.


-N-acetyl D-galactosaminidase in bulk separated neurons and neuropil from rat cerebral cortex.


The synthesis of acetylcholine by the olivo-cochlear bundle.


Chloramphenicol- and cycloheximide-sensitive protein synthetic systems in brain mitochondrial and nerve-ending preparations.


The association of lesion-induced reductions in brain monoamines with alterations in striatal carbohydrate metabolism.


Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro.


Developmental patterns of sulphate activation and phenolsulphotransferase in rat brain.


A soluble preparation from rat brain that incorporates into its own proteins ( 14 C)arginine by a ribonuclease-sensitive system and ( 14 C)tyrosine by a ribonuclease-insensitive system.


A novel approach to the synthesis of nitrogen analogs of the tetrahydrocannabinols.


A new method for the synthesis of optically active  -amino acids and their N    derivatives via acylamino malonates.


Protection of tyrosine in solid-phase peptide synthesis.


2,2-Anhydropyrimidine nucleosides. Novel syntheses and reactions.


Elimination reactions on the di- and trimesylated derivatives of N 3 -benzyluridine.


Use of L-1,4-cyclohexadiene-1-alanine in peptide synthesis as a phenylalanine analog.


Development of tolerance in pigeons to behavioral effects of a new benzopyran derivative.


Involvement of nigro-striatal neurons in the in vivo release of dopamine by amphetamine, amantadine and tyramine.


The rate of formation of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate in brain as an estimate of the rate of formation of norepinephrine.


Specific inhibition by  -methyltyrosine of amphetamine-induced amine release from brain.


Effects of sympathomimetic drugs on incorporation in vivo of intracisternally injected  33 Pi into phospholipids of rat brain.


Effects of atropine, tetrodotoxin and lidocaine on rebound excitation of guinea-pig small intestine.


Effect of propranolol on the fast inward sodium current in frog atrial muscle.


The effects of lidocaine on potassium efflux from various tissues of dog heart.


Electrophysiologic effects of phenothiazines on canine cardiac fibers.


Influence of baroreceptor reflexes on cardiovascular responses of the dog to acetylstrophanthidin.


The effect of clonidine on adrenergic nerve function in vagotomized and nonvagotomized animals.


Study of the mechanisms of the modifying actions of hexamethonium on the cardiovascular response to norepinephrine.


SCH 10595, an effective dopamine- -hydroxylase inhibitor and a hypotensive agent.


Renal hemodynamic and natriuretic effects of furosemide and hydrochlorothiazide in dogs with reduced renal blood flow.


Renal tubular conjugation and excretion of phenol and p-nitrophenol in the chicken: differing mechanisms of renal transfer.


Hepatic excretory function in the newborn rat.


Effect of oxygen on cyanide intoxication. V. Physiologic effects.


Effect of phenobarbital and SKF 525A on the toxicity, elimination and metabolism of cyclophosphamide in newborn mice.


Metabolism of methylhistamine formed through a new pathway: decarboxylation of L-3-methylhistidine.


Effect of inhibitors of protein and ribonucleic acid synthesis on the hyperbilirubinemia and cholestasis produced by  -naphthylisothiocyanate.


The effect of smoking on serum somatotropin, immunoreactive insulin and blood glucose levels of young adult males.


Kinetics of spherulite growth in cholesteryl esters.


Light scattering and microscopic investigations of mesophase transitions of cholesteryl myristate. II. Kinetics of spherulite formation.


Light scattering and microscopic investigations of mesophase transition of cholesteryl myristate. I. Morphology of the cholesteric phase.


Management of fractures with associated arterial injury in combat casualties.


The Illinois plan for a statewide system of trauma centers.


Tissue levels of catecholamines in patients with different types of trauma.


Hemodynamic monitoring for physiologic evaluation, diagnosis, and therapy of acute hemopericardial tamponade from penetrating wounds.


Emergency care for fatalities from injury and illness in the nonhighway setting.


An improved critical care record.

An improved critical care record.


Cardiac tamponade following wound tract injection.


Traumatic coronary artery-right atrial fistula caused by a penetrating metal fragment.


Arteriosclerotic aneurysm of the axillary artery.


Subclinical fat embolism: a prospective study of 50 patients with extremity fractures.


Mallory-Weiss syndrome presenting as a gastric tumor.


Congenital atresia of the colon.

Congenital atresia of the colon.


Medical review--friend or foe?

Medical review--friend or foe?


The community's disaster plan.

The community's disaster plan.


Potassium depletion in hepatic cirrhosis. A reversible cause of impaired growth-hormone and insulin response to stimulation.


Reorganization of National Health Service 1974--for better or for worse?


Pulmonary mucociliary clearance in cystic fibrosis.


Cilia and cystic fibrosis.

Cilia and cystic fibrosis.


Shall we allow heroin maintenance?

Shall we allow heroin maintenance?


Abortion services in Massachusetts.

Abortion services in Massachusetts.


Frequency and nature of sickling disorders.


"Per cent prothrombin activity" unacceptable.


Hearing a fourth heart sound.

Hearing a fourth heart sound.


Pain and CPK elevation after intramuscular digoxin.


Mechanism of beta-blockade hypotension.

Mechanism of beta-blockade hypotension.


Guanidine in amyotrophic lateral sclerosis.


No cerebral dominance for memory.

No cerebral dominance for memory.


Congenital deafness and Hirschsprung's disease.


Containing heroin abuse.

Containing heroin abuse.


Physicians' perceptions of risks of drug use.


Effect of L-DOPA on brain acetylcholine and choline in rats.


Effects of physostigmine on brain acetylcholine content and release.


Further structure-activity studies on the lowering of brain 5-hydroxyindoles by 4-chloramphetamine.


Enhancement of spatial preferences by (+)-amphetamine.


Receptor involvement in the central noradrenergic inhibition of ACTH secretion in the rat.


Biological activity of apomorphine fragments: dissociation of emetic and stereotypical effects.


Electrical correlates of preconvulsive and convulsive doses of chlorinated hydrocarbon insecticides in the CNS.


A new approach to spectral recording applied to the study of low-temperature thermoluminescence.


The in vitro photochemistry of biological molecules. 3. Absorption spectra, lifetimes and rates of oxygen quenching of the triplet states of beta-carotene, retinal and related polyenes.


A remarkable deuterium effect on the rate of photosensitized oxidation of alcohol dehydrogenase and trypsin.


The triplet state of retinal: is it involved in vision?


The destruction of tryptophanyl residues in trypsin by 280-nm radiation.


A new mental health profession.

A new mental health profession.


A night in crisis.

A night in crisis.


Ritual circumcision and castration anxiety.


Readjustment to time in old age. A life cycle approach.


Psychiatric epidemiology of an Indian village.


A cooperative program in materials development for very young hospitalized children.


A visual perception test for motorically impaired children.


Alkaline esophagogastritis with ulceration of the gastric remnant.


Keloids: reassessment of irradiation therapy.


Traumatic arteriovenous fistula. A case report.


Alkaline relux gastritis. Surgical management.


Isolation of 16 -hydroxy-2-methoxyestrone from rat bile.


Effects of norethindrone (17-ethynyl-17 -hydroxy-4-estren-3-one) and norgestrel (dl-13 -ethyl-17-ethynyl-17 -hydroxy-4-gonen-3-one) on the tissue distribution of  3 H-estradiol-17  in ovariectomized rats.


Bioconversion of the androgen precursors by pre- and post-pubertal rat testes with special reference to local irradiation and gonadotropin stimulation.


Determination of serum testosterone and androstanediol by competitive protein binding.


19-hydroxy steroids. V. 3 ,7 ,19-Trihydroxy-5-androsten-17-one 3,19-diacetate: a potential precursor in the biosynthesis of B-ring unsaturated estrogens.


19-hydroxy steroids. VI. Approaches to the synthesis of 7,19-disubstituted androgens.


Metabolism of  3 H-digitoxigenin by rat liver, adrenal, and ovary homogenates.


Reflex bradycardia elicited from left ventricular receptors during acute severe hypoxia in cats.


Increased N-acetylserotonin and melatonin formation induced by d-amphetamine in rat pineal gland organ culture via a  -adrenergic receptor mechanism.


Circulatory responses to stimulation of medullated and non-medullated afferents in the cardiac nerve in the cat.


Metabolism of fracture callus of rat in vitro. I. Oxygen consumption and lactic acid production.


Nonlinear dynamic properties of a somatomotor reflex system. A model study.


The effect of hypercapnic acidosis upon the energy metabolism of the brain in arterial hypotension caused by bleeding.


Effect of physical training on hemodynamic response during submaximal and maximal exercise in 11-13-year old boys.


Repetitive impulse firing: comparisons between neurone models based on 'voltage clamp equations' and spinal motoneurones.


Glyoxylic acid condensation: a new fluorescence method for the histochemical demonstration of biogenic monoamines.


Cerebral blood flow in ischemia caused by carotid artery ligation in the rat.


Spectral sensitivity of the compound eye in a moth. Intra- and extracellular recordings.


Choline acetyltransferase and cholinesterase in the pancreatic duct of the cat.


EEG synchronization and sleep induced by stimulation of the medial and orbital frontal cortex in cat.


The metric system and clinical chemistry.


Simplified automated solubility test for the detection of hemoglobin S applicable to mass screening.


Clear cell acanthoma: clinicopathologic analysis of 37 new cases.


Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases.


Pseudosarcoma of the larynx.

Pseudosarcoma of the larynx.


Lesions of toxemia in first trimester pregnancies.


A computer-assisted information system for anatomic pathology.


Anaerobic prostatic abscess with bacteremia.


A simple method for the determination of gold in serum, blood, and urine by atomic absorption spectroscopy.


Ethanol in sequestered hematomas.

Ethanol in sequestered hematomas.


A simple time-saving method for interpretative report generation. I. Lactate acid dehydrogenase isozymes.


A quenching technic for serum creatine phosphokinase determination.


A simple time-saving method for interpretative report generation. II. Lipoprotein phenotyping.


Laboratory suggestions: simple disposable midstream urine specimen separator and collector.


The Stratford scale, a means of weighing bodies.


Modification of a bone marrow biopsy needle.


Units in blood cell counts.

Units in blood cell counts.


Platelets.

Platelets.


Urinary tract candidiasis: report of a case with bilateral ureteral obstruction. A brief review of the literature on urinary tract candidiasis is presented. The presence of Candida albicans in the urine is rather uncommon and most patients have candiduria without any apparent disease. Among the others, three different clinical types of infection are recognized: (1) pyelonephritis, (2) lower urinary tract infection and (3) ureteral obstruction. Of this last type only seven cases were found in the literature; four of the patients died. We add one case in which the patient did very well after the obstruction of the ureters was relieved by means of ureteral catheters and a large urinary output was maintained for several days.


Tyrosinosis: a new variant.

Tyrosinosis: a new variant. ABNORMALITIES OF TYROSINE METABOLISM ARE DISCUSSED UNDER FOUR HEADINGS: (1) accumulation of tyrosine and its metabolites secondary to severe liver damage, vitamin C deficiency, etc.; (2) transient neonatal tyrosinemia; (3) hereditary tyrosinosis with hepatorenal dysfunction where elevation of tyrosine and methionine levels in the plasma may be a secondary manifestation of an unknown disease process; and (4) "essential tyrosinemia" or tyrosinosis without hepatorenal dysfunction which may represent a kkrimary fault in the metabolism of tyrosine.A new case of tyrosinosis without hepatorenal dysfunction in a 13-year-old mentally retarded girl is reported. Clinical findings, laboratory investigations and results of dietary management and normalization of the plasma tyrosine level and of urinary metabolites are presented and compared with the features of three similar cases in the liteature. It is suggested that these cases represent "essential tyrosinemia" where there is a primary genetic defect in tyrosine metabolism.


Coronary patients and their families receive incomplete care.


Computer-aided instruction at the Ottawa General Hospital. We have reviewed our experiences with the first systematic use of CAI at the University of Ottawa Medical School. The Bleich acid-base and electrolyte program was employed by senior clinical clerks in the Department of Medicine during the past year using APL version of the program, an IBM 360-65 computer linked by acoustic coupler to the typewriter-style IBM 2741 terminal. We have been impressed with the importance of: (1) minimizing technical difficulties, (2) enhancing the teaching capacity of the program (as opposed to its consultant function) and (3) carefully ensuring that the user understands its limitations. This pilot project in clinical CAI has identified problems which will likely be experienced in other medical centres and has suggested important areas for further development.


Acupuncture.

Acupuncture.


Health care at Toronto International airport.


Pegboard as space saver.

Pegboard as space saver.


Trace elements in food.

Trace elements in food.


VON coordinates health care for seniors.


Collagenolytic-cathepsin and acid-proteinase activities in the rat uterus during post partum involution.


Carbamoylation of proteins following administration to rats of carbamoyl phosphate and cyanate and effects on memory.


Phoratoxin, a toxic protein from the mistletoe Phoradendron tomentosum subsp. macrophyllum (Loranthaceae). Improvements in the isolation procedure and further studies on the properties.


Cooperative ligand binding by ferrihemoglobin.


Steroid-binding properties of a plasma-membrane fraction from rat liver.


The effect of bifunctional and monofunctional azo-dye reagents upon the oxygen-binding mechanism of human hemoglobin.


The influence of steric and electronic parameters on the substrate behavior of  -oxo acids to yeast pyruvate decarboxylase.


Aggregation of chlorophylls in vitro. Absorption spectroscopy of chlorophyll a in water-solutions.


Nuclear and cytoplasmic DNA synthesis during the mitotic cycle of HeLa cells.


Effects of a potent catatoxic steroid, 16 -cyanopregnenolone, on microsomal metabolism of steroid hormones, sterols and bile acids in rats.


Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition.


Aggregation of chlorophylls in vitro. Role of the magnesium atom and of the phytyl chain in the chlorophyll a molecule.


Identification of polysomes synthesizing thyroglobulin.


Demonstration of two types of proteins synthesized in isolated rat-liver mitochondria.


Cholesterol turnover in patients with chronic liver disease.


Influence of bile salts on cholesterol synthesis in the isolated perfused rat liver.


Acrylamide electrophoresis and binding ability of hepatic ribosomal protein from normal and from diabetic rats.


Serum guanase in kidney diseases.

Serum guanase in kidney diseases.


Reversal of the EHDP inhibition of calcium absorption by 1,25-dihydroxycholecalciferol.


The role of fatty acid and of hormones in the determination of myocardial carbohydrate metabolism in healthy fasting men.


Criteria for assessment of functional impairment in patients with cirrhosis of the liver.


Effect of glucose on the induced synthesis of bacterial respiratory nitrate reducatse and tetrathionate reductase.


Diphasic production of secondary metabolites by Penicillium notatum Westling S-52. I. Biosynthesis of eitrinin.


Identification of beryllium on the organs.


Clay minerals as a factor influencing the biochemical activity of soil microorganisms.


Comparative morphology and histology of the alimentary canal in two teleost fishes.


A case of situs viscerum inversus totalis observed in a 75-year-old woman.


The pedagogic training of academic teachers at the medical faculty.


Multiple-choice tests in practical classes and in examinations in histology and embryology.


Similarity and dimensional analysis, evaluation of aerosol deposition in the lungs of laboratory animals and man.


Atypical kinocilia in the tracheal epithelium.


Morphogenesis of the tarsus in some rodentia.


The ultrastructure of the gingivo--dental junction in rat molars. I. The epithelia.


The ultrasturcture of the gingivo--dental junction in rat molars. II. The capillaries.


Schistosoma mansoni: changes in the outer membrane of the tegument during development from cercaria to adult worm.


An investigation of the interactions of some factors influencing the infectivity of Schistosoma mansoni miracidia to Biomphalaria glabrata.


Electron microscopy and histochemistry of oncospheral hook formation by the cestode Catenotaenia pusilla.


Differences in esterase frequencies in five strains of Biomphalaria glabrata (Say).


The role of serine in the lipid metabolism of the rat tapeworm Hymenolepisdiminuta.


Subcellular distribution of digestive enzymes in Ascaris suum intestine.


The blood incubation infectivity test as a means of distinguishing between Trypanosoma brucei brucei and T. brucei rhodesiense.


The food additives amendment and fat and oil bearing foods.


Cryopreservation of the promastigote form of Leishmania tropica var major at different cooling rates.


Differential diagnosis with cholesteric liquid crystal photography.


Kodagraphy photomicrography.

Kodagraphy photomicrography.


Enhancement of radiographs by dodged masking.


Impact of television on the health sciences.


The helix coil transition of DNA. Observed with an inexpensive uv photometer.


Marine natural products. Pigments.

Marine natural products. Pigments.


TLC detection of caffeine in commercial products.


An investigation of sebum and other facial lipids.


Two convenient spectrophotometric enzyme assays. A biochemistry experiment in kinetics.


Informed consent--the doctor's dilemma.

Informed consent--the doctor's dilemma.


Pulmonary embolectomy for massive pulmonary embolus.


Holidays for humanity.

Holidays for humanity.


New techniques in the diagnosis and treatment of hypertension.


Who teaches whom?

Who teaches whom?


New recommendations for simultaneous administration of live virus vaccines.


Urinary tract infection.

Urinary tract infection.


Antitussive agents.

Antitussive agents.


Dialysis in Iowa. Questions & answers.

Dialysis in Iowa. Questions & answers.


Acute renal failure: success and failure of treatment.


Radiology window: case no. 10.

Radiology window: case no. 10.


Clinical cardiology. His bundle recordings and arrhythmias.


Multicentricity in cancer of the breast.


In the spinal analysis.

In the spinal analysis.


Liability for blood transfusion violating religious beliefs.


Antibiotics in the therapy of salmonellosis.


The Kentucky foundation for medical care. Continuing education--in the midst of rapid change.


Study of maternal mortality.

Study of maternal mortality.


Cutaneous xanthomatoses.

Cutaneous xanthomatoses.


Malignant melanoma: a case report.

Malignant melanoma: a case report.


Progressive vaccinia (vaccinia gangrenosum).


Professional standards review organization.


Understanding continuing medical education.


Fasciotomy in the treatment of plantar keratosis and other conditions of the foot.


The A, B, C's of mechanical ventilation. I. Flow through a tube.


The health crisis and health care administration.


Guest editorial: outbreak of paralytic poliomyelitis.


Organized medicine and the developing Oklahoma Public Health service.


Massive peer review program required by congress.


Sinusitis or malignancy?

Sinusitis or malignancy?


Developmental physiology of cestodes. 13. Vitamin B 6  requirement of Hymenolepis diminuta during in vitro cultivation.


Two new diving duck hosts for Plasmodium circumflexum.


A potential intermediate host of Schistosoma mansoni in Grenada.


Inhibition of pancreatic lipase by Hymenolepis diminuta.


CO2 production by extracts of Hymenolepis diminuta (Cestoda: Hymenolepididae) with aspartate and -ketoglutarate as substrates.


Host resistance in a natural host-parasite system. Resistance to Hymenolepis citelli by Peromyscus maniculatus.


Morphologic anomalies in scoleces of larval Taenia crassiceps.


Redescription of Trichuris (equals Trichocephalus) schumakovitschi (Savinkova, 1967) from Canadian Rocky Mountain bighorn sheep (Ovis canadensis canadensis).


Galba modicella and Lymnaea stagnalis as experimental intermediate hosts for Fascioloides magna in Minnesota.


Ascaris suum: a scanning electron microscope study.


Ultrastructure of dormant, activated, and intracellular sporozoites of Eimeria adenoeides and E. tenella.


The North American genus Otorhinophila Wrenn and Loomis (Acarina: Tromibculidae), with the descriptions of three new species.


Experimental development of a cambendazole-resistant strain of Haemonchus contortus in sheep.


New species of Palaeopsylla Wagner, 1903, from Nepal, with a discussion of the Remota species group (Siphonaptera: Hystrichopsyllidae).


Transmission of Eimeria separata from the normal host, Rattus, to the mouse, Mus musculus.


Migration inhibition test of splenic cells of chickens infected with Eimeria tenella.


Babesia thomasi from rock hyraces in Kenya.


Isolation of toxoplasma from soil.

Isolation of toxoplasma from soil.


Toxoplasmosis of the two-toed sloth, Choloepus didactylus, in Brazil.


Incidence of Hirudinella marina Garcin, 1730 (Trematoda: Hirudinellidae) in tunas from the Atlantic Ocean.


Action of oxyclozanide against adult Fascioloides magna (Bassi, 1875) infections in white-tailed deer.


Cultivation of Schistosoma mansoni daughter sporocysts in arthropod tissue cultures.


Oncomelania hupensis from the schistosomiasis focus in Central Sulawesi (Celebes), Indonesia.


Potential role of uninfected predators in schistosome dissemination.


Absorption of glucose and sodium acetate by cysticercoid larvae of Hymenolepis diminuta.


Transport of 3-0-methylglucose by various regions of the intestine of Ascaris suum.


Neutral alkoxylipids of Ascaris suum.

Neutral alkoxylipids of Ascaris suum.


Abnormal Ternidens deminutus Railliet and Henry, 1909 (Nematoda) from man in Rhodesia.


Blood microfilariae: new and existing techniques for isolation.


Development of Brugia pahangi in male mosquitoes.


Natural transmission of Demodex bovis Stiles in cattle.


Structure of the oocysts and excystation processes of four Eimeria spp. (Protozoa: Eimeriidae) from the Colorado pika, Ochotona princeps.


Structure of the oocyst and sporocyst walls and excystation of sporozoites of Isospora canis.


The ingestion of red blood cells by Schistosoma mansoni.


Toxic effects of freshwater turbellarians on Schistosome miracidia.


Polycyclorchis eudocimi gen. et sp. n. (Trematoda: Cyclocoelidae) from the trachea of the white ibis, Eudocimus albus L.


Observations on some Heterophyidae (Trematoda: Digenea) encysted in Philippine fishes.


Some aspects of the larval development of Cyclocoelum obscurum (Tremtaoda: Cyclocoelidae).


Thyroxine and red cell 2,3-diphosphoglycerate in the newborn period.


The use of 99m-Tc-pertechnetate for the determination of red cell volume.


Discontinuities (gaps) of the glomerular capillary wall and basement membrane in renal diseases.


Effect of intracerebral injection of ouabain in adult and developing rats. An ultrastructural and autoradiographic study.


Long term cultures of Hodgkin's tissue. A morphologic and radioautographic study.


Ultrastructural changes in hepatic cells of the male rat induced by DL-ethionine.


Postmortem dimensions of the coronary arteries in different geographic locations.


Chronic glomerulonephritis induced by prolonged immunization in the rabbit.


Effect of isoproterenol on synthesis and secretion in the rat parotid gland.


Atherosclerotic lesions and coronary heart disease. Key relationships in necropsied cases.


Thrombocytopenia of hibernation. Mechanism of induction and recovery.


Early services available for blind children.


Clinical-pathologic and medicolegal aspects of coronary artery disease.


Sustained isometric handgrip. A useful bedside maneuver.


E.N.T. case of the month.

E.N.T. case of the month.


Clinical application of two new noninvasive cardiovascular technics.


Clinical applications of the carotid sinus reflex.


Centralized pressure in sphygmomanometry.


Continuing education opportunities for physicians in Ohio.


His bundle recordings and arrhythmias.

His bundle recordings and arrhythmias.


The when and where of continuing medical education in Ohio.


The professional approaches the fee collection problem.


Major orthopaedic reconstructive surgery. Newer concepts now in use.


Anxiety.

Anxiety.


Elevated creatinephosphokinase in myxedema.


Subungual melanoma.

Subungual melanoma.


An investigation on the cyclodesulphurization of some pseudothiohydantoin derivatives: the cyclodesulphurization of thio-compounds. 4.


New 4-aryl-2-hydroxytetronimides and their derivatives: aryl analogs of iminoascorbic acid.


Studies on hashish. 5- Identification of cannabidiol and cannabidiolic acid by ultraviolet spectrophotometry.


Use of the water bed for prevention of pressure sores.


Classification and surgical correction of gynecomastia.


Is plastic surgery effective in the rehabilitation of deformed delinquent adolescents?


Mortality and causes of death in burned patients treated by the exposure method.


Augmentation of surface contour by subcutaneous injections of silicone fluid. A current report.


Variations of the motor branch of the median nerve at the wrist. Case report.


Moebius syndrome associated with the mother taking thalidomide during gestation. Case report.


Conserving surgical instruments and operating room time.


Use of acrylic obturators to protect suture lines in the hard palate.


Conversion of thyroxine to triiodothyronine by cultured human cells. Human liver and kidney cells convert 6 to 10 percent of added thyroxine to triiodothyronine in vitro at 37 degrees C. This extent of conversion is ten times greater than that in control studies with killed cells. Conversion is evident within 10 minutes and appears to be maximal within 1 hour. Greater net triiodothyronine formation results if greater amounts of exogenous thyroxine are added to the system, with no plateau evident even at very high thyroxine concentrations. The addition of high concentrations of nonradioactive triiodothyronine resulted in no evident inhibition of the conversion.


Central norepinephrine metabolism in affective illness: MHPG in the cerebrospinal fluid. Concentrations of the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl glycol in cerebrospinal fluid were measured by a gas chromatographic method in 34 patients with affective illness and in 44 controls. Concentrations of this metabolite in spinal fluid were significantly lower in depressed patients than in controls or manic patients. These low values may occur secondary to depressive phenomena such as reduced psychomotor activity, or they may reflect a primary change in norepinephrine metabolism in depressive illness.


Androgen-concentrating cells in the midbrain of a songbird. Androgen-concentrating cells were found in the midbrain of the chaffinch Fringilla coelebs by autoradiography using tritiated testosterone. Labeled cells were localized primarily in the nucleus intercollicularis, an area from which vocalizations can be electrically stimulated in birds. These autoradiographic results suggest that the nucleus intercollicularis is a site in the action of androgens on avian vocal behavior.


Swallowing in fetal sheep.

Swallowing in fetal sheep. Swallowing was measured in fetal sheep by using electromagnetic flowmeter heads chronically implanted in the fetal esophagus. The fetus swallows 20 to 200 milliliters of amniotic fluid in two to seven discrete episodes per day. The episodes are 1 to 9 minutes in duration and occur at seemingly random intervals. Swallowing is influenced by the condition of the fetus and may be the first manifestation of eating and drinking behavior.


Genetic mechanisms determining the central visual pathways of mice. Albino mammals have abnormal visual pathways. "Flecked" mice have a variegated pigment distribution, with roughly half the cells normally pigmented and half albino. They do not show the albino abnormality in the visual pathways. The gene at the albino locus, which determines the course of the visual pathways must, thus, have an extracellular action.


Opiate receptor: demonstration in nervous tissue. Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.


Neurologic manifestations of the Noonan syndrome.


Maternal behavior in the rat: facilitation through gonadectomy. Virgin rats were ovariectomized and tested for induction of maternal behavior by being housed with neonatal young. A postoperative interval of 8 weeks yielded an average latency for the onset of maternal behavior significantly lower than that for intact controls or for virgin females ovariectomized 4 weeks before testing. Replacement of estrogen in the group ovariectomized for 8 weeks or injection of the estrogen antagonist ethamoxytriphetol (MER-25) in the group ovariectomized for 4 weeks changed the average latencies accordingly. Parallel results were obtained for males that were castrated 4 or 8 weeks before testing. It is concluded (i) that maternal behavior is under gonadal control and that this control is normally inhibitory; and (ii) that only after long-term removal of the gonads, resulting presumably in the complete clearance of estrogen and testosterone, is the maternal mediating system finally released from steroid suppression.


Fibrosis of the anterior chamber.

Fibrosis of the anterior chamber.


Survival of a patient following left nephrectomy with suprarenal and infrarenal vena caval resection.


Diagnosis and treatment of nasopharyngeal tumors.


Evaluation of blood glucose in neonates with a reflectance meter.


Nephrostomy and the cancer patient.

Nephrostomy and the cancer patient.


A descriptive assessment of the psychiatric practice of nonpsychiatric physicians in South Carolina.


Experience with dismembered pyeloplasty: interesting complications.


Complications in the urinary tract related to treatment of carcinoma of the cervix.


The scope of illicit drug use in a Vietnam combat unit.


A clinical evaluation of the intrauterine device for control of conception.


Ben H. Nicholson Memorial Lecture. Congenital syphilis: a review of its present status and significance in pediatrics.


Chronic intravascular coagulation syndrome associated with atherosclerotic aortic aneurysm.


Current concepts in therapy: rifampin.

Current concepts in therapy: rifampin.


Treatment of whipworm infection with thiabendazole.


Protection from sunlight: evaluation of a new screening agent.


Alcoholic ketoacidosis.

Alcoholic ketoacidosis.


Letter to the editor: community disaster planning. Emergency beds.


Anomalous origin of the left coronary artery from the pulmonary trunk in an adult: angiographic diagnosis.


A modified micromethod for determination of iron in tissue.


A quality control product for urinalysis.


Experiences with a screening test for bacteriuria.


Aeromonas shigelloides bacteremia: a case report.


The observer error in peripheral blood cell classification.


A precision study of coagulation factor assay technics.


Plexiform tumorlet of the uterus: report of two cases.


Aspirin as an antiplatelet agent: template bleeding time as a monitor of therapy.


Primary neonatal hyperparathyroidism--an unusual cause of failure to thrive.


The differential radiosensitivity of oogonia and oocytes at different developmental stages of the brine shrimp, Artemia salina.


The effects of acute gamma irradiation on the brine shrimp, Artemia. 3. Male F reproductive performance following paternal irradiation of mature sperm.


Demonstration of an action of acetylcholine on the central nervous system of a crab.


Differential renal protein clearance in diabetes.


Glucose, insulin, and free fatty acids in uremia.


Tests for glucosuria. An analysis of factors that cause misleading results.


The course of diabetic retinopathy. A longitudinal study.


Modeling blood glucose and insulin kinetics in normal, diabetic and obese subjects.


Comparative study of in vitro hydrodynamic behaviour between three differently designed fascia lata valves and the Starr-Edwards prosthesis in aortic position.


Epidemiologic studies of serum glucose levels among Micronesians.


Skin cleavage lines in the rat.

Skin cleavage lines in the rat.


Hemisphere differences in cognitive capacity in the split-brain cat.


Audiogenic seizure susceptibility of rats X-irradiated in Utero late in pregnancy.


Mechanisms mediating ipsilateral limb hyperflexion after cerebellar paravermal cortical ablation or cooling.


The influence of locomotion on flexor reflex of the hind limb in cat and man.


Does self-regulation of breathing need a feedback from the respiratory muscles?


Extracellular potassium concentration changes during propagated seizures in neocortex.


Hyperphagia after midbrain lesions involving the medial lemniscus.


Visual-deficit following long-term continuous light exposure.


The island model of population differentiation: a general solution. The island model deals with a species which is subdivided into a number of discrete finite populations, races or subspecies, between which some migration occurs. If the number of populations is small, an assumption of equal rates of migration between each pair of populations may be reasonable approximation. Mutation at a constant rate to novel alleles may also be assumed.-A general solution is given for the process of population divergence under this model following subdivision of a single parental population, expressed in terms of the observed average frequency of heterozygotes within and between subpopulations at a randomly chosen set of independently segregating loci. No restriction is imposed on the magnitude of the migration or mutation rates involved, nor on the number of populations exchanging migrants.-The properties of two fundamental measures of genetic divergence are deduced from the theory. One is a parameter related to varphi, the coefficient of kinship, and the other, gamma, measures the rate of mutational divergence between the sub-populations.


Auditory detetion of frequency transition.


Transglottal airflow during stop consonant production.


Electric network effects in the cochlea.


The influence of human factors on the performance of a real-time speech recognition system.


Shift of ear superiority in dichotic listening to temporally patterned nonverbal stimuli.


Perception of dichotically presented vowels.


Discrimination of fundamental frequency contours in synthetic speech: implications for models of pitch perception.


Application of the claisen rearrangement to the synthesis of trans trisubstituted olefinic bonds. Synthesis of squalene and insect juvenile hormone.


Determination of the tautomeric form of the imidazole ring of L-histidine in basic solution by carbon-13 magnetic resonance spectroscopy.


Structural chemistry of cyclic nucleotides. II. Crystal and molecular structure of sodium  -cytidine 2',3'-cyclic phosphate.


Structural chemistry of cyclic nucleotides. 3. Proton magnetic resonance studies of  -pyrimidine nucleotides.


C 8  epimeric 10,11-anhydroerythromycins A and the C 8  epimeric 11,12-epoxyerythromycins A.


C 8  epimerizations of erythromycin B and 10,11-anhydroerythromycin B 1 .


Synthesis of corticosteroids from marine sources.


Conformational dependence of vicinal H-N-C-H coupling constants in peptides.


Addition of hydroxyl radicals to pyrimidine bases and electron transfer reactions of intermediates to quinones.


Kinetics of the reaction of amine complexes of cobalt(II) protoporphyrin IX dimethyl ester with oxygen. Evidence for hydrogen bonding with coordinated oxygen.


Complex formation between purine and indole derivatives in aqueous solutions. Proton magnetic resonance studies.


Steric and electronic effects in the coordination of amines to a cobalt(II) porphyrin.


Specific and fluorescent modifications of cytidine.


p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments.


Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea.


Nonenzymic nitrogen fixation by an iron-molybdenum model for nitrogenase.


A facile cyclization-decyclization reaction of a 4',5'-didehydroadenosine derivative. A new route to the chemical modification of adneosine.


Cytosine nucleoside-nucleotide series. Electrochemical study of reduction mechanism, association, and adsorption.


Cancer of the lung. A preventable disease.


Fruit and vegetable acceptance by students. Factors in acceptance and performance.


One-year trial of prescribing diets by a dietitian.


An improved ketogenic diet for treatment of epilepsy.


Ketogenic diet containing medium-chain triglycerides.


Pathogenetic mechanisms in hypertension.


The diagnostic evaluation of the hypertensive patient.


The office therapy of hypertension.

The office therapy of hypertension.


Adult coarctation of the aorta.

Adult coarctation of the aorta.


Complications of hypertension.

Complications of hypertension.


Hypertension.

Hypertension.


Derivation of wavelength discrimination from color naming.


Light-acceptance property of an optical fiber.


Ocular-dioptric-component changes in the growing rabbit.


Branched-chain N-sugar nucleosides. 1. Nucleosides of branched-chain cyanomethyl, aminoethyl, and N,N-dimethylcarbamoylmethyl allo sugars. 6-N,N-dimethylamino-9-(3'-C-(N,N-dimethylcarbamoylmethyl)-3'-deoxy- -D-allofuranosyl)purine.


Branched-chain N-sugar nucleosides. 2. Nucleosides of 3-C-cyanomethyl-, carboxamidomethyl-, and N,N-dimethylcarboxamidomethyl-3-deoxyribofuranose. Synthesis of a homolog of the amino sugar nucleoside moiety of puromycin.


6-ALKYL PENICILLINS AND 7 ALKYL CEPHALOSPORINS.


Deoxy oligonucleotide synthesis via the triester method.


The chemistry of some 5-(2-hydroxyalkyl)uracil derivatives and a synthesis of 5-vinyluracil.


S-acylcysteine peptides. Synthesis and kinetics of hydrolysis.


The addition of dihalocarbenes to 3 -acetoxy-B-norandrost-5-en-17-one.


Sensitized photolyses of DDT and decyl bromide.


Aporphine synthesis by Pschorr cyclization of aminophenols. An improved synthesis of a thalicarpine precursor.


Delayed union and nonunion of fractures: clinical experience with the ASIF method.


Increased antidiuretic hormone production after trauma to the craniofacial complex.


Volkmann's contracture and femoral shaft fractures.


Early changes in rat skin following thermal injury.


Tube paracentesis without lavage.

Tube paracentesis without lavage.


Arthrography of the shoulder: a review.

Arthrography of the shoulder: a review.


The effect of environmental temperature and fluid therapy on mortality and metabolism of mice after burn and tourniquet trauma.


Management of traumatic peripheral arteriovenous fistulas.


Your involvement in emergency medical services.


Biomechanical features of traumatic paraplegia in infancy.


Presidential address: why an AAST?

Presidential address: why an AAST?


Amniotic fluid and fetal maturity.

Amniotic fluid and fetal maturity.


Burn toxin in mouse skin.

Burn toxin in mouse skin.


The Weed system. An innovative approach toward better medical records.


Congenital left circumflex coronary artery fistula to right atrium without a murmur.


Neuologic manifestations of Henoch-Schoenlein purpura, 1972.


Headache: recognition and treatment. A brief review for the physician.


Adolescents and "street" drug abuse. A scientific exhibit.


The child with recurrent respiratory tract infections.


Amantadine in extrapyramidal syndromes induced by neuroleptic drugs.


Briggs and the health visitor.

Briggs and the health visitor.


'I was nineteen and I wanted to die'.

'I was nineteen and I wanted to die'.


The magic of dermatology. 6. Skin diseases common to animals and to man.


Arthur.

Arthur.


Ad infinitum.

Ad infinitum.


Final state practical examinations at Guy's Hospital.


Is your hospital progressive?

Is your hospital progressive?


The elderly at the end of life.

The elderly at the end of life.


Aggression in the general hospital.

Aggression in the general hospital.


Energy output and work stress in coastal fishing.


The renal excretion of cortisol.

The renal excretion of cortisol.


The Bohr effect and the Haldane effect.

The Bohr effect and the Haldane effect.


Plasma and urinary cortisol in pregnancy and during estrogen-gestagen treatment.


Activity of alpha-1,4-glucosidase in human serum.


Increase of post-heparin lipase activity by oxandrolone in familial hyperchylomicronemia.


Studies on soluble fibrin in plasma. 3. N-terminal analysis of a modified fraction I (Cohn) from plasmin- and thrombin-incubated plasma.


Calf blood pressure measurements. The applicability of a plethysmographic method and the results of measurements during reactive hyperaemia.


The inhibition of tissue plasminogen activator and urokinase-induced fibrinolysis by some natural proteinase inhibitors and by plasma and serum from normal and pregnant subjects.


Effects of fasting on adipose tissue perfused in situ in young dogs.


Effect of physical training on anatomical R-L shunt at rest and pulmonary diffusing capacity during near-maximal exercise in boys 11-13 years old.


Effect of physical training on pulmonary ventilation and gas exchange during submaximal and maximal work in boys aged 11 to 13 years.


The prospects for a stationary world population.


Folate activity of human lymphocytes determined by measurement of serine synthesis.


The asymmetry of the human brain.

The asymmetry of the human brain.


Hepatic drug metabolism in rats: impairment in a dirty environment. Reduction of aniline hydroxylase activity, ethylmorphine N-dementhylase activity, and cytochrome P-450 content occurred in hepatic microsomes of rats kept under dirty conditions, defined as accumulation for 1 week of urine and feces in pans under the wire mesh cages. In comparison with rats that had urine and feces removed twice daily from such pans, rats kept over Kimpak bedding or over Litter Green, changed twice daily, also showed reduced drug-metabolizing activity in hepatic microsomes, but to a lesser degree than the dirty rats. Placement of a filter top on cages for 1 week also decreased drug-metabolizing activity. These experiments suggest that the relative cleanliness of an animal's environment can influence hepatic microsomal drug metabolism.


Carnitine deficiency of human skeletal muscle with associated lipid storage myopathy: a new syndrome. In a rare myopathy muscle fibers contained myriad lipid-filled vacuoles. Homogenates of the patient's muscle oxidized fatty acids more slowly than normal (11 controls). Addition of carnitine increased the oxidation rate with the patient's muscle to the level attained by the controls with carnitine. In five separate muscle samples from the patient the mean carnitine level was less than 20 percent of that observed in 42 controls. Carnitine palmityl transferase and palmityl thiokinase levels in the patient's muscles were not depressed. The present case represents the first recognized instance of carnitine deficiency in human skeletal muscle.


Amine metabolites in human cerebrospinal fluid: effects of cord transection and spinal fluid block. Patients with spinal cord transection had normal concentrations of 5-hydroxyindoleacetic acid and low concentrations of 3-methoxy-4-hydroxyphenyl glycol in lumbar cerebrospinal fluid. The presence or absence of spinal fluid block in these patients did not affect concentrations of either amine metabolite. However, the concentration of homovanillic acid was lower in patients with spinal fluid block than in those without block. The results suggest that the spinal cord contributes to concentrations of 3-methoxy-4-hydroxyphenyl glycol and possibly 5-hydroxyindoleacetic acid, but contributes little to that of homovanillic acid in the lumbar spinal fluid of man.


Fate of the nucleus of the marrow erythroblast. Nucleated red cells lose their nuclei during passage through the endothelium of marrow sinuses. The passage occurs through cytoplasmic pores which are not gaps at the junction of two endothelial cells but perforations within the endothelium. Enucleation occurs because the pores are of relatively fixed size. Whereas the cytoplasm is flexible and squeezes through the pore, the nucleus is rigid and cannot conform to the pore size. It is, thus, caught, and the red cell becomes enucleated.


Effect of surgical operation on human blood viscosity.


Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Monoamine oxidase activity in blood platelets was measured, with [(14)C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers. The monoamine oxidase activity of both schizophrenic and nonschizophrenic co-twins was significantly lower than it was for the normals, and it was highly correlated between twins. In addition, there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity. These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia.


Muscle activity, body fat, and induced rat mammary tumors.


On the proteins of hydrocele fluid.

On the proteins of hydrocele fluid.


Peripheral atheroembolism: confirmation of a clinical concept, with a case report and review of the literature.


Septisol antiseptic foam for hands of operating room personnel: an effective antibacterial agent.


Progressive peripheral fibromuscular hyperplasia in an infant: a possible manifestation of the rubella syndrome.


The anatomic basis for respiratory variation in median arcuate ligament compression of the celiac artery.


Leiomyosarcoma of large arteries and veins.


Plasma cortisol and cortisone concentrations following postoperative adrenal steroid replacement.


Inhibition of serotonin-induced blood cell aggregation in the dog.


Changes in lung and body weight and lung water content in rats treated for hemorrhage with various fluids.


Inguinal hernia and colon carcinoma: presentation of a series and analysis.


Experimental arterial thrombosis formation in vivo by proteolytic enzyme perfusion and the role of elastin layer.


Protective effect of myocardial glycogen on cardiac function during anoxia.


Postmortem angiography and dissection of the hypogastric artery in pelvic fractures.


A new technique for preparing totally hepatectomized pigs.


A model for the repeated evaluation of ventricular function in the intact animal.


Questioning gastrin assay methods.

Questioning gastrin assay methods.


Technique of electromagnetic blood flow measurements: notes regarding a potential source of error.


Mechanical impedance of supine humans under sustained acceleration.


Neuroendocrine, cardiorespiratory, and performance reactions of hypoxic men during a monitoring task.


Effects of some antimotion sickness drugs and secobarbital on postural equilibrium functions at sea level and at 12,000 feet (simulated).


Influence of workload on the neurological state of a pilot during the approach and landing.


Theoretical trans-respiratory pressure during rapid decompression. I. Model experiment.


Theoretical trans-respiratory pressures during rapid decompression. II. Animal experiments.


Fire retardance of mixtures of inert gases and oxygen.


Assessment of temperature rise suppression by edge losses during irradiation.


Intravascular changes associated with hyperbaric decompression: Theoretical considerations using ultrasound.


Proposed new test for aptitude screening of air traffic controller applicants.


The Harry G. Armstrong Lecture. Stress and aerospace medicine.


USAFSAM Cardiovascular Disease Followup Study: 1972 progress report.


A study of Halon 1301 (CBrF 3 ) toxicity under simulated flight conditions.


Human exposure to Halon 1301 (CBrF 3 ) during simulated aircraft cabin fires.


The WAVR File.

The WAVR File.


Altered hemoglobin oxygen affinity in patients with acute myocardial infarction.


Depressed inotropic state and reduced myocardial oxygen consumption in the human heart.


Immediate hemodynamic effects of cardiac angiography in man.


Hemodynamic study of 85 patients with borderline hypertension.


Tritiated digoxin. XIX. Turnover studies in diabetes insipidus.


Experimental myocardial infarction. IX. Efficacy of hyperbaric oxygenation in ventricular failure after coronary occlusion in intact conscious dogs.


Sinus slowing produced by experimental ischemia of the sinus node in dogs.


Isometric effects on treadmill exercise response in healthy young men.


"Floating" catheter for temporary transvenous ventricular pacing.


Minoxidil in severe hypertension with renal failure. Effect of its addition to conventional antihypertensive drugs.


Thymic cyst simulating multiple cardiovascular abnormalities and presenting with pericarditis and pericardial tamponade.


Right-sided heart failure in aortic stenosis.


Traumatic aneurysm of left anterior descending coronary artery with fistulous opening into left ventricle and left ventricular aneurysm after stab wound of chest. Report of case with successful surgical repair.


Posttraumatic coarctation of the aorta. Diagnostic clues.


Dysfunction of the Beall mitral prosthesis and its detection by cinefluoroscopy and echocardiography.


Atrioventricular junctional parasystole with concealed conduction simulating second degree atrioventricular block.


Pulmonary wedge catheter.

Pulmonary wedge catheter.


Simple diagram for presenting coronary arteriographic and ventriculographic findings.


The quandary of quality: incompetence among the excellent.


The use of group counseling procedures in the rehabilitation of spinal cord injured patients.


The therapeutic social club.

The therapeutic social club.


The current status of the use of prostaglandins in induced abortion.


Consumers of Washington Heights Family Planning Center, New York City and community comparison women.


Increased iron allowances.

Increased iron allowances.


Health professionals in Pennsylvania.

Health professionals in Pennsylvania.


Microwave oven survey results in Arkansas during 1970.


Wildlife as monitors of disease.

Wildlife as monitors of disease.


Heroin addiction in the suburbs--an epidemiologic study.


Health planning--a method for generating program objectives.


Hospital and related characteristics associated with perinatal mortality.


Drug overdoses in a Canadian city.

Drug overdoses in a Canadian city.


An examination of some directions in health care policy.


Screening for utilization review: on the use of explicit criteria and non-physicians in case selection.


Community injury control--a management approach.


Family planning--changes in attitudes and practices among low income women between 1967 and 1970-71.


Serum copper in Hodgkin's disease in children.


Factors associated with dropping out of family planning clinics in Jamaica.


Roentgenologic aspects of Hodgkin's disease. II. Role of routine radiographs in detecting initial relapse.


Carcinoembryonic antigen (CEA) in the diagnosis of pancreatic cancer.


Carcinoembryonic antigen in pancreatitis.


Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: correlation with tumor stage and histology.


Anesthetic-induced increase in murine mortality from cyclophosphamide.


Tumors of the mandible and maxilla in children. I. Clinicopathologic study of 46 histologically benign lesions.


Mesonephroma of the ovary. A clinical, morphological, and histogenetic appraisal.


Medullary carcinoma of thyroid gland. Subcellular distribution of calcitonin and relationship between granules and amyloid.


Lymphangiomyomatosis: a clinico-anatomical entity.


Embryonal rhabdomyosarcoma of the prostate. An ultrastructural study.


Theca granuloma cell tumor arising in adrenal.


Serum   2 -microglobulin in various disorders.


Determination of  -amylase in serum and urine of subjects with a low bicarbonate concentration in the duodenal aspirate after secretin stimulation.


Adenosine triphosphate utilization by "young" and "old" red cells.


Investigations on acid phosphatase activity in human plasma and serum.


Determination of lower fatty acids, particularly the anti-epileptic dipropyl-acetic acid, in biological materials by means of micro diffusion and gas chromatography.


Changes in renal function in the rat during bromosulphophthalein (BSP) infusion.


Serum cholesterol determination by gas-liquid chromatography.


The use of suspensions of isolated rat mucosal cells to study mechanisms of iron absorption.


The role of allied health personnel in streptococcal control.


Respiratory and food-borne streptococcal epidemics.


Secondary prevention of rheumatic fever.


Noise monitoring and a sociological survey in the city of Toronto.


Family surveys of irritation symptoms during acute air pollution exposures. 1970 summer and 1971 spring studies.


Seasonal changes in serum and nassal IgE concentrations.


A morphometric study on the nexus of rat cardiac muscle. A morphometric study of the nexus of rat cardiac muscle was carried out. The nexus surface of one intercalated disk of one 15 microm thick fiber is found to range between 47 microm(2) and 94 microm(2), the latter value taking into account the maximal underestimation caused by tangential sectioning. Dividing the lower, minimal value by the surface of the observed subunits (90 A periodicity), one obtains for one intercalated disk 6.7 x 10(5) subunits, each of them assumed to be permeated by a central pore. These pores are thought to be equivalent to intercellular channels in a recently proposed model. Taking our morphometric and recently reported physiological values, this model is examined for its consistency with a low resistance pathway between cardiac muscle cells.


Branching patterns of individual sympathetic neurons in culture. The growth of single sympathetic neurons in tissue culture was examined with particular regard to the way in which the patterns of axonal or dendritic processes (here called nerve fibers), were formed. The tips of the fibers were seen to advance in straight lines and to grow at rates that did not vary appreciably with time, with their position in the cell outgrowth, or with the fiber diameter. Most of the branch points were formed by the bifurcation of a fiber tip (growth cone), apparently at random, and thereafter remained at about the same distance from the cell body. It seemed that the final shape of a neuron was the result of the reiterated and largely autonomous activities of the growth cones. The other parts of the cell played a supportive role but, apart from this, had no obvious influence on the final pattern of branches formed.


A role for anionic sites in epithelial architecture. Effects of cationic polymers on cell membrane structure. The effects of several cationic polymers (poly-L-lysines, protamine, and histone) on rabbit gall bladder epithelial cells were studied to explore possible roles for negative sites in the membrane. The tissue was bathed for 30 min at 37 degrees C in Ringer's solutions containing from 0.1 to 100.0 microg/ml of cationic polymers, and subsequently was fixed with 1% OsO(4) and examined with the electron microscope. All cationic polymers, at appropriate concentrations, produced similar changes in membrane structure. Adjacent membranes frequently were fused. Membrane structures such as microvilli lost rigidity. Cell membranes showed an apparent increase in permeability as judged by osmotically traumatized cells. These results indicate that fixed anionic sites play significant roles in stabilizing epithelial membrane structures.


A study of 323 consecutive hip fractures at Madison State hospital.


Radioautographic visualization of the deposition of a phosphoprotein at the mineralization front in the dentin of the rat incisor.


Hypnosis and homeostasis between mother and child.


Malpractice insurance--England and the United States.


Hyperthyroidism with a functioning nodule.


Professional corporations increasingly popular.


Neurosurgical emergencies.

Neurosurgical emergencies.


Evaluation of several methods of surgical scrub.


Administrative aspects of general medical practice under England's National Health Service.


Radiologic seminar CXXV: pancreatic scanning.


"A look at medicredit".

"A look at medicredit".


Nursing education.

Nursing education.


The martyr's personality: an experimental investigation.


The role of verbal self-instructions in children's resistance to temptation.


Who reports shoplifters? A field-experimental study.


Conservatism and art preferences.

Conservatism and art preferences.


Experimenter-subject interaction as a function of authoritarianism and response set.


An improved technique for tracheostomy in infants and children.


Tics, delusions, and phobias.

Tics, delusions, and phobias.


Two minutes with the oral contraceptives.


From a malpractice lawyer's case book. Diagnosis of Appendicitis.


Be careful when you prescribe these drugs.


Polymyalgia rheumatica--a wastebasket for assorted aches.


Questions in cardiology.

Questions in cardiology.


Two minutes with diabetes.

Two minutes with diabetes.


Abnormalities at the stage of chemical asymptomatic diabetes.


The definition of chemical diabetes in children.


Oral glucose tolerance tests and their reliability.


The intravenous glucose tolerance test in chemical diabetes.


Hemoglobin A1 C  in childhood diabetes.

Hemoglobin A1 C  in childhood diabetes.


II. Interpretation criteria for OGTT. Introduction.


Chemical diabetes mellitus in the child.


Chemical diabetes in children: glucose tolerance tests.


Standardization of the oral glucose tolerance test and the criteria for diagnosis of chemical diabetes in children.


Carbohydrate metabolism in children: (1) blood sugar, serum insulin, and growth hormone during oral glucose tolerance tests; (2) blood sugar during the cortisone glucose tolerance test.


Criteria for interpretation of the oral glucose tolerance tests in children and insulin responses with normal and abnormal tolerance.


Glucose tolerance sums and glucose: insulin ratios in children.


Adult-onset diabetes mellitus in childhood.


Screening for glucose intolerance in a pediatric multiphasic program.


Mass urine glucose screening in children.


Studies on the natural history of asymptomatic diabetes in young people.


Relationship between diabetes mellitus and obesity in the child.


Chemical diabetes in the juvenile patient.


Screening for glucose intolerance in siblings of children with diabetes.


Metabolic aspects of obesity.

Metabolic aspects of obesity.


Glucose tolerance testing in children with random glucosuria with symptoms suggestive of hypoglycemia and with idiopathic hypoglycemia of infancy.


IV. Therapy of chemical diabetes. Introduction.


Treatment of chemical diabetes mellitus with sulfonylurea compounds.


Treatment of the child with chemical diabetes mellitus.


Experiences in sulfonylurea therapy.

Experiences in sulfonylurea therapy.


Early diabetes mellitus in children.

Early diabetes mellitus in children.


Chemical diabetes in children: tolbutamide experience.


Insulin treatment of children with late chemical diabetes.


The scanning electron microscope and its applications to research.


Changes in the CSF during pneumoencephalography.


Aortocranial and carotid angiography in determination of brain death.


Changes in meningeal and cerebral circulation in subarachnoid haemorrhage. A preliminary report.


Early pattern of cerebral circulatory disturbances following subarachnoid haemorrhage.


Comparison of the venous phase of carotid arteriography with direct intracranial venography in the evaluation of lesions at the base of the skull.


Effects of ketamine in cerebral angiography.


The vertebral angiogram in patients with tumours in or near the midline.


One man's opinion.

One man's opinion.


Ultrasonic diagnosis of embryonic malformations.


Gynecologic oncology: present status and future aspects.


Effects of acute maternal hypoxia and hyperoxia on the blood flow to the pregnant uterus.


The effect of nutrition in teen-age gravidas on pregnancy and the status of the neonate. I. A nutritional profile.


Carcinoma of the endometrium.

Carcinoma of the endometrium.


Studies on the pathogenesis of clotting defects during salt-induced abortions.


The practicing physician as curriculum designer: views of behavioral science.


Progress in the surgical treatment of pancreatic disease.


Ileal pouch with ileostomy rather than ileostomy alone.


Acupuncture, electric phenomenon of the skin, and postvagotomy gastrointestinal atony.


Reappraisal of rectum-retaining operations for ulcerative and granulomatous colitis.


Geriatric colon cancer.

Geriatric colon cancer.


Anorectal suppurative disease. A retrospective review.


Gastrografin-induced hypertonicity. The pathogenesis of a neonatal hazard.


Portal decompression by splenic vein implantation into liver or kidney.


Effect of taurocholic acid and BSP on conjugation patterns and suspension stability of human and rat bile.


Use of an elemental diet in the treatment of complicated pancreatitis.


Treatment of experimental acute pancreatitis with 5-flourouracil (5-FU).


Effect of alcohol on duodenal-pancreatic reflux.


Bile duct injury. Results of repair using a changeable stent.


Overlooked gallstones and their retrieval.


A sensitive radioisotope assay for pectin methyl esterase activity.


Elimination of amino acid losses with protein acid hydrolyzates due to adsorption.


Stopped flow method at subzero temperatures.


Electrophoresis of isolated mitochondria.


An improved haptoglobin subtyping procedure using polyacrylamide gel electrophoresis. Haptoglobin gene frequency distribution among a group of blood bank donors.


An improved scintillation cocktail of high-solubilizing power.


A fortran IV computer program for automatic calculation of amino acid composition.


Catalytic hydrogenations of several 18-oxygenated 3-keto-  4 -steroids.


A simple colorimetric assay for catechol-O-methyl transferase.


A simple, rapid method to process and assay fatty acids and alcohols by gas chromatography.


A fluorometric method for the detection of endodeoxyribonuclease on DNA-polyacrylamide gels.


Synthesis of homohypotaurine (3-aminopropansulfinic acid) and homothiotaurine (3-aminopropanthiosulfonic acid).


New internal standards for basic amino acid analyses.


-Glucosidase contaminant in enzymatic reagent for glucose detection.


Partial hydrolysis of MS2 RNA with RNase U2, B. amyloliquefaciens RNase, or micrococcal nuclease.


Quantitative assay of 3'-phosphoadenosine-5'-phosphosulfate, "active sulfate".


Computer-determined rate constants of hemolysis induced by Prymnesium parvum toxin.


A new simplified protein hydrolysis apparatus.


Paper chromatographic assay of ( 3 H)norepinephrine and its five major metabolites.


Difficulties encountered with an ultrafiltration method for measuring the binding of ligands to protein.


Laser sideband spectroscopy: a macromolecular probe.


A specific kinetic assay for phenylalanine hydroxylase.


Atmospheric pollen counts in Toronto, Canada, 1971.


Atmospheric mold counts in Toronto, Canada, 1971.


Enzyme-potentiated hyposensitization. Effects of glucose, glucosamine, N-acetylamino-sugars and gelatin on the ability of F -glucuronidase to block the anamnestric resposen to antigen in mice.


Allergy to pyramidon (aminopyrine).

Allergy to pyramidon (aminopyrine).


Effect of Tylophora indica on bronchial tolerance to inhalation challenges with specific allergens.


Surgical experience with staging laparotomy in 125 patients with lymphoma.


Acute and late reactions to irradiation in the treatment of Hodgkin's disease.


Splenectomy effects on chemotherapy in Hodgkin's disease.


Chemotherapy of Hodgkin's disease. Maintenance therapy vs no maintenance after remission induction with combination chemotherapy.


Chemotherapy of Hodgkin's disease in studies by acute leukemia group B.


Eastern cooperative oncology group studies.


Combination chemotherapy-radiotherapy for stage 3 Hodgkin's disease. An acute leukemia group B study.


Spokesmen for medicine.

Spokesmen for medicine.


Combined chemotherapy radiotherapy management of stage 3 Hodgkin's disease.


Relapse in tuberculosis. A report from the Research Committee of the South-East Metropolitan Regional Thoracic Society.


Imprint cytology at endoscopy for the rapid diagnosis of bronchial and oesophageal malignancy.


Mediastinal reticulosis with hypertrophic pulmonary osteoarthropathy.


Alpha-1-antitrypsin deficiency and intrinsic asthma.


Primary leiomyosarcoma of the lung.

Primary leiomyosarcoma of the lung.


Publication cures for which there is no disease.


To needle, brush, cut or watch?

To needle, brush, cut or watch?


Insertion site for heart catheters.

Insertion site for heart catheters.


Attachment for automated single breath diffusing capacity measurement.


Correlations of electrocardiographic features with airway obstruction in chronic bronchitis.


Aspiration biopsy in diagnosis of pulmonary nodule.


Submaximal treadmill exercise evaluation in patients with symptoms of cardiovascular disease. An aid to rehabilitation and re-employment.


Plethora of colors out of silver white.

Plethora of colors out of silver white.


Left axis deviation: diagnostic contribution of exercise stress testing.


Demand pacemaker arrhythmias from intermittent internal short circuit in bipolar electrode.


The flow volume loop: normal standards and abnormalities in chronic obstructive pulmonary disease.


Comparison of a new Mono-Vacc tuberculin test with the Mantoux test.


Clinical evaluation of myocardial perforation as a complication of permanent transvenous pacemakers.


Left atrial volume calculation by angiocardiography in children.


Aortico-right ventricular tunnel.

Aortico-right ventricular tunnel.


A study of arrival of excitation at selected ventricular sites during human bundle branch block using close bipolar catheter electrodes.


Metastatic pulmonary diseases: biologic factors and modes of treatment.


Management of postpneumonectomy space. Appraisal of a technique used in 408 consecutive cases.


Ehlers-Danlos syndrome and cardiovascular abnormalities.


Primary sternal osteomyelitis.

Primary sternal osteomyelitis.


The femoral route for cardiac catheterization of infants and children.


Illustrative echocardiograms: mitral valve motion in severe aortic regurgitation.


Roentgenogram of the month. Right upper mediastinal mass.


Methadone pulmonary edema.

Methadone pulmonary edema.


Nocardial endocarditis following mitral valve replacement.


Bronchospirometric findings in scimitar syndrome and a new method for the differentiation of anomalous venous drainage from atrial septal defect.


Bronchopleural cutaneous fistula from infected pacemaker electrodes.


Normalization of prolonged IV conduction time in a patient with acute pulmonary embolism.


Superior vena cava obstruction due to sarcoidosis.


Anomalous origin of the right coronary artery from the pulmonary artery.


Midsystolic clicks and coronary heart disease.


Intrafissural midzonal anthracotic lymph node.


A large series does not parallel E-MC 2 .


Commercial air transportation of a patient recovering from pneumothorax.


Neutralization of endogenous luteinizing hormone by antibodies in prepubertal female rats.


Follicle response to exogenous gonadotropins: an estrogen-mediated phenomenon.


On the presence of deoxyribonuclease (DNASE) in the rabbit epididymis and its possible significance in the removal of spermatozoa.


Vasectomy and seminal prostaglandins.

Vasectomy and seminal prostaglandins. This study was undertaken to see whether any changes in the concentration of seminal PGs (Prostaglandins) occurred following vasectomy when the testes are no longer in continuity with the lower genital tract.  Samples of seminal fluid from males undergoing vasectomy were obtained on the day of operation, and 12 and 16 weeks after the operation.  The samples were stored at -15 degrees Celsius and all analyses were carried out within 1 week of receipt.  Prostaglandin content was analyzed by means of thin-layer chromatography and spectrophotometry.  There was a significant rise in the level of all prostaglandins measured 12 weeks after the operation.  At 16 weeks postvasectomy, both PGEs and PGAs were at a significantly higher level than before the operation, but the 190H PGAs were not.  Only 1 man did not show any change in PGE concentration over the 16-week period, although marked changes were observed in his PGA level and 190H PGAs.  2 men exhibited lower seminal PGE levels after vasectomy and little change was observed in the level of other prostaglandins measured in 1 of these 2 men.  All sperm counts fell to zero 12 weeks after vasectomy.  The study shows that prostaglandins do not rise, even in part, as a secretion from the testis.


Correlation between sperm motility and electrolyte composition of seminal fluid in normal and infertile men.


Culdoscopic tubal sterilization.

Culdoscopic tubal sterilization.


Effect of oral diethylstilbestrol on plasma progesterone.


Peripheral serum progesterone and correlated endometrial glycogen levels during the menstrual cycle of Macaca arctoides.


Introductory remarks at the inaugural meeting of the Western Division of the American Geriatrics Society, Los Angeles, California.


A look into the future of Geriatric medicine.


Fasting serum cholesterol and triglyceride levels in the elderly: relation to glucose homeostasis.


Long-term results with oral hypoglycemic drugs.


Serum lipids, serum uric acid and glucose tolerance in coronary heart disease.


Recognition, relevance and deactivation of gerontophobia: theoretical essay.


Elderly women in institutions versus those in public housing: comparison of personal and social adjustments.


Is there an anemia responsive to pantothenic acid?


Disseminated leiomyosarcomatosis: case report.


Reciprocal innervation: phase analysis of demodulated EMGs from antagonistic muscles.


Rapid fluid replacement following thermal dehydration.


Simultaneous comparison of helium and nitrogen expiratory "closing volumes".


Influence of various catecholamines on aortic regurgitation.


Independent effects of changes in H+ and CO 2  concentrations on hypoxic pulmonary vasoconstriction.


Effect of passive 70 degrees head-up tilt on peripheral visual response time.


Effect of exercise on gastrointestinal secretions.


Local electrical response of the skin to deformation.


Blood volumes and total body water in the domestic pony.


A description of lung distortion due to localized pleural stress.


Effects of anesthetic and pyrogen on thermally sensitive neurons in the brainstem.


Effect of depth of inhalation on aerosol persistence during breath holding.


Effect of smoking a single cigarette on the "small airways".


Dependence of inert gas narcosis on lipid "free volume".


A new portable temperature-sensing device.


A modified Singer-Hastings nomogram.

A modified Singer-Hastings nomogram.


Inertial pressure losses in perfused hindlimb: a reinterpretation of the results of Whittaker and Winton.


A stochastic time series model for hand tremor.


Nitrogen and helium "closing volumes": simultaneous measurement and reproducibility.


Calibration of nonlinear gas analyzers using exponential washout and polynomial curve fitting.


Production of rat muscle atrophy by cast fixation.


Betaine-homocysteine transmethylase in Pseudomonas denitrificans, a vitamin B 12 overproducer. A pantothenate-methionine auxotroph (J741) of Pseudomonas denitrificans was isolated whose growth requirement for methionine could not be satisfied by known precursors of the amino acid, including homocysteine. However, some "methyl rich" compounds such as betaine and dimethylacetothetin (DMT) could satisfy the requirement. S-Methyl-methionine and S-adenosylmethionine were ineffective. Extracts were found to contain an enzyme, betaine-homocysteine transmethylase (BHTase), that uses betaine or DMT as a methyl donor and homocysteine as an acceptor to produce methionine. Growth of J741 in methionine leads to a total repression of the BHTase, whereas the use of DMT leads to a three- to sixfold stimulation of enzyme synthesis compared to betaine-grown cells. The pantothenate requirement is unrelated to the methionine auxotrophy, since the growth of other single auxotrophic mutants as well as revertants of J741 still have their methionine requirement satisfied by betaine or DMT. Another methionine auxotroph that could not use betaine for growth was devoid of BHTase activity.


Thymineless death and ultraviolet sensitivity in Micrococcus radiodurans. Thymine-requiring mutants of Micrococcus radiodurans have been isolated by selection on solid medium containing trimethoprim. Strains requiring either high concentrations of thymine (50 mug/ml) or low concentrations (2 mug/ml) for normal growth were obtained. The Thy(-) mutant requiring low thymine concentrations has been characterized. It was shown to retain the high ultraviolet light (UV) resistance typical of wild-type M. radiodurans, but it was not resistant to thymineless death. Preliminary exposure of the cells to thymineless conditions resulted in enhanced UV sensitivity, and this interaction occurred under conditions where "unbalanced growth" was inhibited by the addition of chloramphenicol. Upon addition of thymine to deprived cells, UV resistance was gradually restored, and this recovery took place in the absence of protein synthesis. A model is proposed to account for the similarity of thymineless death in bacteria whose deoxyribonucleic acid repair efficiencies differ widely.


Distribution of a phosphoenolypyruvate-dependent sugar phosphotransferase system in mycoplasms. A survey of 10 mycoplasma strains has shown that their capacity to accumulate radioactivity from alpha-methyl-d-glucopyranoside depends on the activity of a phosphoenolpyruvate-dependent phosphotransferase system (PTS), and that this system endows the organisms with a high affinity for glucose as a fermentation substrate. PTS activity was found in Mycoplasma gallisepticum, M. mycoides var. mycoides, and M. mycoides var. capri, but in none of the fermentative Acholeplasma strains nor in some of the nonfermentative Mycoplasma species. Partial characterization of the PTS of M. mycoides var. capri has shown that, like the PTS of Escherichia coli and Staphylococcus aureus, it is strictly dependent on phosphoenolpyruvate as a phosphoryl donor and on componenets of both the cytoplasm and the membrane.


Partial purification and properties of the pyruvate-uridine diphospho-N-acetylglucosamine transferase from Staphylococcus epidermidis. A method for the partial purification of the pyruvate-uridine-diphospho-N-acetylglucosamine transferase from Staphylococcus epidermidis is presented. Some properties of the enzyme are discussed.


Pathways of carbohydrate metabolism in Microcyclus species. Radiorespirometric and enzymatic studies were conducted to determine primary and secondary pathways of carbohydrate catabolism in Microcyclus aquaticus and M. flavus. M. aquaticus catabolizes both glucose and gluconate mainly via the Entner-Doudoroff and pentose phosphate pathways with some concurrent participation of the Embden-Meyerhof pathway. M. flavus, however, oxidizes glucose mainly via the Embden-Meyerhof pathway and gluconate via the Entner-Doudoroff pathway with some simultaneous operation of the pentose phosphate pathway. Both of the organisms showed evidence of the tricarboxylic acid cycle as a secondary pathway for the oxidation of carbohydrates.