Self-association of theophylline in aqueous solution.


Factors affecting release of medicaments from hard gelatin capsules.


Batch production of pharmaceutical granulations in a fluidized bed. 3. Binder dilution effects on granulation.


Orthokinetic coagulation in pharmaceutical suspensions.


Compendial dissolution tests: merits of sequential over standard inspection plans.


Theoretical treatment of diffusional transport into and through an oil-water emulsion with an interfacial barrier at the oil-water interface.


A new tablet disintegrating agent: cross-linked polyvinylpyrrolidone.


Caffeine complexes with low water solubility: synthesis and dissolution rates of 1:1 and 1:2 caffeine-gentisic acid complexes.


Deuterium isotope effect in enzymatic transamination of L-deuterio-phenylalanine to deuterio-phenylpyruvic acid.


In vitro dissolution and in vivo absorption of nitrofurantoin from deoxycholic acid coprecipitates.


Misconceptions and thermodynamic untenability of deviations from pH-partition hypothesis.


Resistance of large-volume parenteral containers to forced microbial contamination.


Evaluation of interactions between polymers and low molecular weight compounds by GLC. I. Methodology and interaction evaluation.


Evaluation of interactions between polymers and low molecular weight compounds by GLC. II. Thermodynamics and elucidation.


Effect of trichloroacetate anion on partition behavior of tetracyclines.


Polypectomy via the fiberoptic colonoscope. Removal of neoplasms beyond reach of the sigmoidoscope.


Diurnal variation in biliary lipid composition. Possible role in cholesterol gallstone formation.


Detection of the carrier state for classic hemophilia.


Hidden conceptual models in clinical psychiatry.


Screening for thalassemia trait by electronic measurement of mean corpuscular volume.


Stilbestrol and urogenital-tract cancer in adolescents and young adults.


Tension hemothorax due to patent ductus arteriosus.


The shoulder-pad sign--a diagnostic feature of amyloid arthropathy.


Fiberoptics: morbidity and cost.

Fiberoptics: morbidity and cost. The authors report on the success of using fiberoptic instruments for laparoscopy, colonoscopy, and polypectomy, thus reinforcing a previous report by Wolff and Shinya of similar successes.  The results showed numerous advantages for using fiberoptics: 1) reduced complications, 2) reduced costs, 3) earlier return to employment and normal activities, and 4) shorter hospital stay.  It is hoped that endoscopic procedures will soon be able to be done under local anesthesia and on an outpatient basis, reducing costs even more.


Poliomyelitis--a persistent problem.

Poliomyelitis--a persistent problem.


Medical care in Massachusetts State prisons.


Treating hypertension.

Treating hypertension.


Drug-sensitive hemoglobinopathies.

Drug-sensitive hemoglobinopathies.


Blood vessels, platelets and fibrinogen.


Technic of lumbar puncture.

Technic of lumbar puncture.


Voluntary peer review.

Voluntary peer review.


Lead in "no-lead" paint.

Lead in "no-lead" paint.


Pessimistic view of American drug therapy.


Illuminating trilogy on health-care delivery.


Special taxes for Massachusetts physicians.


Radiation dosimetry by a new solid-state effect. Ionizing radiation can induce strong electrical polarization phenomena in dielectic solids. These radiation-induced thermally activated depolarization (RITAD) effects are quite different from radioelectret effects. For nominally pure calcium fluoride samples, the RITAD signals show a signal-to-noise power advantage of 40 decibels over that of thermoluminescence signals measured under the same experimental conditions. Ease of measurement, very high radiation sensitivity, and simple sample fabrication requirements give the RITAD phenomena a great potential for use as a new solid-state dosimetry technique.


Feedback: beyond behaviorism.

Feedback: beyond behaviorism. Consistent behavior patterns are created by variable acts, and generally repeat only because detailed acts change. The accepted explanation of this paradox, that "cues" cause the changes, is irrelevant; it is unsupported by evidence, and incapable of dealing with novel situations. The apparent purposefulness of variations of behavioral acts can be accepted as fact in the framework of a control-system model of behavior. A control system, properly organized for its environment, will produce whatever output is required in order to achieve a constant sensed result, even in the presence of unpredictable disturbances. A control-system model of the brain provides a physical explanation for the existence of goals or purposes, and shows that behavior is the control of input, not output. A systematic investigation of controlled quantities can reveal an organism's structure of control systems. The structure is hierarchical, in that some quantities are controlled as the means for controlling higher-order quantities. The output of a higher-order system is not a muscle force, but a reference level (variable) for a lower-order controlled quantity. The highest-order reference levels are inherited and are associated with the meta-behavior termed reorganization. When controlled quantities are discovered, the related stimulus-response laws become trivially predictable. Variability of behavior all but disappears once controlled quantities are known. Behavior itself is seen in terms of this model to be self-determined in a specific and highly significant sense that calls into serious doubt the ultimate feasibility of operant conditioning of human beings by other human beings.


Scanning electron microscopy: low-magnification pictures of uncoated zoological specimens. Good low-magnification (x 5 to x 500) scanning electron microscope pictures of dry, uncoated zoological specimens may be obtained with a low accelerating voltage (1.5 to 3 kilovolts) in conjunction with a short exposure to the scanning beam.


Pituitary gonadotrophs: nuclear concentration of radioactivity after injection of ( 3 H)testosterone. Gonadotrophs and castration cells in the male rat pituitary showed nuclear concentration of radioactivity 1 hour after [1,2,6,7-(3)H]testosterone injection. Thyrotrophs and acidophils did not retain radioactivity; also the cells of the intermediate and posterior lobes did not accumulate radioactivity. The autoradiographic results suggest a direct and selective action of androgen on gonadotrophs, which contrasts with the action of estradiol which was shown earlier to bind not only to basophils but to acidophils and chromophobes as well.


Delta-9-tetrahydrocannabinol: localization in body fat. [(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Delta(9)THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Delta(9)THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Delta(9)THC and its metabolites accumulated in fat and brain.


Somatosensory cortex: structural alterations following early injury to sense organs. In mouse somatosensory cortex there are discrete cytoarchitectonic units, called "barrels." Each barrel is related to one sensory vibrissa on the muzzle. Individual vibrissae were carefully injured at birth; 12 to 43 days later, the corresponding barrels proved to be absent. Evidently the sensory periphery has an important influence on the structure of the somatosensory cortex.


Phenothiazine dosage levels and auditory signal detection in schizophrenia.


Fibrogenic effect of alcohol in rat liver: role of diet.


Health needs of the youth subculture.

Health needs of the youth subculture.


Commonly missed injuries in the hand.

Commonly missed injuries in the hand.


Corticosteroids in the treatment of skin disorders.


Alpha and beta receptors.

Alpha and beta receptors.


Current ideas about bronchiectasis.

Current ideas about bronchiectasis.


Direct measurement of less than 1 part-per-billion fluoride in rain, fog, and aerosols with an ion-selective electrode.


Separation of astatine-211 from bismuth metal.


The direct determination of chromium in urine by selective volatilization with atom reservoir atomic absorption.


Study of the application of atomic fluorescence spectrometry to the direct determination of mercury and cadmium in the atmosphere.


Studies in the complex formation of metal ions with sugars. I. The complex formation of cobalt(II), cobalt(3), copper(II) and nickel(II) with mannitol.


Nonfasting state and the absorption of a hypnotic.


Ammonia tolerance in assessing the patency of portacaval anastomoses. A long-term controlled investigation.


Nuclear cerebral angiography. Usefulness in the differential diagnosis of cerebrovascular disease and tumor.


Howell-Jolly bodies. Intracellular or extracellular?


Progressive hereditary nephropathy. A variant of medullary cystic disease?


Pericardial tamponade in chronic-hemodialysis patients treatment by pericardectomy.


Coccidioidomycosis. An occupational disease in cotton mill workers.


Familial benign essential hematuria.

Familial benign essential hematuria.


Renal cortical necrosis in a male adult. Documented recovery.


What to do with the bean from a patient's ear.


Nail-Patella syndrome. Light and electron microscopic studies of the kidney.


Colorado Tick Fever. A review of 115 laboratory confirmed cases.


Prostaglandins as therapeutic agents.

Prostaglandins as therapeutic agents.


Photoreactions of pseudouridine 3'-phosphate.


Preparation of O'-alkyl derivatives of cytosine and uracil nucleosides.


Reconstitution of 50S ribosomal subunits from protein-free ribonucleic acid.


Selective stimulation of nonhistone chromatin protein synthesis in lymphoid cells by phytohemagglutinin.


Isolation, purification, and fractionation of nonhistone chromosomal proteins.


Histone synthesis during early embryogenesis in Xenopus laevis (South African clawed toad).


Mössbauer studies of cytochrome P-450 cam .


Subunit composition of haptoglobin 2-2 polymers.


Spectroscopic and magnetic studies of iron(3) gastroferrin.


Dynamic behavior of fluorescent probes in lipid bilayer model membranes.


Kinetics of the thrombin-induced release of calcium (II) by platelets.


Fatty acid chain elongation in rat brain synaptosomes.


Reaction of sulfite with isoalloxazines.


Preparation and characterization of free cell suspensions from the immature rat uterus.


Isolation and characterization of 3-O- -D-xylopyranosyl-D-glucose and 2-O- -L-fucopyranosyl-D-glucose from normal human urine.


On the mechanism of action of streptococcal proteinase. I. Active-site titration.


On the mechanism of action of streptococcal proteinase. II. Comparison of the kinetics of proteinase- and papain-catalyzed hydrolysis of N-acylamino acid esters.


The impact of the Abortion Act.

The impact of the Abortion Act.


On the mechanism of action of streptococcal proteinase. 3. The effect of pH, organic solvents, and deuterium oxide on the proteinase-catalyzed hydrolysis of N-acylamino acid esters.


Suicide in Brighton.

Suicide in Brighton.


Lactate-induced anxiety: hypothesis and experimental model.


Thiamine deficiency in the aetiology of the hallucinatory state complicating alcoholism.


Depressive illnesses in late life.

Depressive illnesses in late life.


Sustained release amitriptyline (lentizol) in depressive illness.


Flupenthixol and the out-patient maintenance treatment of schizophrenia.


Flupenthixol in the treatment of depressive states.


Intravenous diazepam in drug-induced dystonic reactions.


Ketamine as an anaesthetic for ECT.

Ketamine as an anaesthetic for ECT.


Genetic theorizing and schizophrenia.

Genetic theorizing and schizophrenia.


Affective disorder on paternal and maternal sides. Observations in bipolar (manic-depressive) patients with and without a family history.


The development of neurosis in the wives of neurotic men. I. Symptomatology and personality.


An examination of individual susceptibility to the influence of aggressive film models.


Anticipatory grief and widowhood.

Anticipatory grief and widowhood.


Methods of recording prescriptions in hospital and their effects on transcribed drug lists.


A system of drug handling in hospital.

A system of drug handling in hospital.


Urogenital malformations associated with anorexia nervosa.


A short anorexic behaviour scale.

A short anorexic behaviour scale.


Personality and psychiatric treatment expectancies.


Changes in psychometric test results following cosmetic nasal operations.


Psychiatric problems of haemodialysis: their treatment by hypnosis.


Effect of alcohol on short term memory in alcoholics.


Lobular carcinoma in situ: incidence and treatment.


Significance of growth rates, cell kinetics, and histology in the irradiation and chemotherapy of squamous cell carcinoma of the mouth.


Serum ribonucleases in cancer: relation to tumor histology.


Malignant schwannoma. A clinicopathologic study.


Plasma cell granulomas of the lung.

Plasma cell granulomas of the lung.


Carcinoma of the colon and rectum: circulating malignant cells and five-year survival.


Myxoma of the jaw bones.

Myxoma of the jaw bones.


Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis.


Hemangiopericytoma. An ultrastructural study.


Rhabdomyosarcoma of head and neck in children. Combination treatment by surgery, irradiation, and chemotherapy.


Malignant tumors of the vagina.

Malignant tumors of the vagina.


Treatment of primary and recurrent retroperitoneal liposarcoma. Twenty-five-year experience at Memorial Hospital.


Lymphocyte reactivity in cancer patients: correlation with tumor histology and clinical stage.


Revision of the clinical staging system for cancer of the larynx.


Characteristics of an inpatient unit for adolescents.


What's a normal adolescent? A guide for the assessment of adolescent behavior.


Youthful alienation and social mobility. A re-evaluation of the whole social mobility ethos is urgently needed.


Death of an adult--and its impact upon the child.


Xerodermic idiocy or De Sanctis Cacchione syndrome. A description of an 8-year-old patient with xeroderma pigmentosum, mental retardation, and dwarfism.


Anemia and increased intracranial pressure in an infant.


Recurrent pneumonia in a five-month-old.


How to begin the private practice of adolescent medicine.


Smoking behavior and young people. The need for new directions.


Studies on the pathogenesis of multiple sclerosis. Participation of lysosomes on demyelination in the central nervous system white matter outside plaques.


Cerebral lipids in a case with a clinically silent isolated plaque of the multiple sclerosis type.


The thalamic hemorrhage. An anatomo-clinical study.


Clinical safety of haloprogin, a new topical antimicrobial.


Orbicularis oculi "myotonia" in hypothyroid myopathy.


Effect of glucagon on heart muscle contractility.


The effect of five per cent carbon dioxide on the response of muscle blood flow to isoproterenol in man.


Pharmacology of orally administered   9 -tetrahydrocannabinol.


Clinical biostatistics. XIX. Ambiguity and abuse in the twelve different concepts of control.


Electrophysiological examinations of the visual system in the acute phase after head injury.


Uptake and distribution of thiopental after oral, rettal, and intramuscular administration: effect of hepatic metabolism and injection site blood flow.


Ths superior ophthalmic vein in carotid angiograms.


Identification of glycinexylidide in patients treated with intravenous lidocaine.


Effects of heat and exercise on the elimination of pralidoxime in man.


Corticoid therapy in chronic obstructive pulmonary disease.


Myocardial infarction.

Myocardial infarction.


Common errors in the diagnosis of spinal meningiomas.


Disposition of diazoxide in children.

Disposition of diazoxide in children.


Crime and delinquency among the aged in Israel.


Difference in surgical risks for older and younger persons.


Value of liver function test before operation.


Sarcoidosis in the aged.

Sarcoidosis in the aged.


L-dopa for parkinsonism.

L-dopa for parkinsonism.


Digoxin in the aged.

Digoxin in the aged.


A study of the reinnervation of fast and slow mammalian muscles. Miniature end plate potential (mepp) frequency in innervated extensor muscle is significantly higher than in soleus muscle. 9 days after nerve crush mepps of low amplitude and prolonged duration reappeared at a frequency of 2% of control and were similar to normal muscles after 35 days. Membrane potential began to increase 9-10 days after nerve crush and at 30 days was similar to controls. The region most sensitive to ACh in denervated and reinnervated muscles was the end plate. Caffeine (20 mM, 23 degrees C) induced contracture in innervated soleus but not in extensor muscles. After denervation the extensor became sensitive to caffeine while the soleus muscles decreased in sensitivity to the drug; 4-5 days after reinnervation the effect of caffeine on these muscles was similar to control. The events during reinnervation are: (a) reappearance of mepps at the same time as end plate potential and muscle twitch; (b) partial restoration of the membrane potential; (c) return of caffeine-induced contracture to normal levels in the soleus and its absence in the extensor muscles; (d) return of membrane resistance to normal values in both muscles at about 25 days; and (e) return of ACh-sensitivity to control levels at about 30 days in both muscles. Although these results suggest that the membrane potential and sarcoplasmic reticulum are under neural influence, it remains to be established whether or not separate neurotrophic factors are involved.


Photoreceptor spike responses in the hardshell clam, Mercenaria mercenaria. Spikes were recorded from single axons in the siphonal nerve of the hardshell clam Mercenaria mercenaria which respond to dimming of light. No axons were found to respond to the onset, or increase, of illumination. In a dark-adapted state there is little or no ongoing spike activity. The responsive area of a single axon is a circle of approximately 85 microm diameter on the inner siphon wall. The number of spikes elicited at the off of constant-duration flashes grows as approximately the 0.4 power of flash intensity. For constant intensity and constant light-time fraction, the off-response increases with increasing duration at least up to 500 s duration. For long durations, the response grows as the logarithm of stimulus duration. Subthreshold light can suppress the off-response from preceding illumination. In a light-adapted state, the off-response is greater and its latency shorter than in the dark-adapted state. The fine structure of groups of cell processes thought to comprise the photoreceptor in Mercenaria is described. On the basis of morphological and physiological findings it is suggested that phototransduction occurs in the fine distal processes of the axons from which we have recorded. Axonal processes were found to contain well organized pentalaminar whorls which may be the site of photo-pigment concentration. The action spectrum obtained from the integrated responses of nerve bundles appears to be that of a single Dartnall pigment having maximal absorption at about 510 nm.


Calcium and facilitation at two classes of crustacean neuromuscular synapses. The closer muscle of the crab, Chionoecetes, has at least two classes of excitatory neuromuscular synapses. In one class of synapses an action potential depolarizing the synaptic region releases much more transmitter if it has been preceded recently by another action potential. The other class of synapses shows this property, called facilitation, to a far lesser extent. Immediately after one conditioning stimulus the level of facilitation is similar in both classes. The rate of the ensuing decay of the facilitation is the critical factor differentiating the two classes of synapses. The relationship between external Ca(++) concentration and transmitter release is similar for both classes of synapses. The slope of a double logarithmic plot of this relationship varies from 3.1 between 5 and 10 mM Ca(++) to 0.9 between 30 and 40 mM Ca(++). Facilitation does not significantly change when tested in external Ca(++) concentrations ranging from 7 to 30 mM. The extracellularly recorded nerve terminal action potential does not increase in amplitude during facilitation. The results suggest that the mechanism of synaptic facilitation is similar for both classes of synapses and occurs after the stage in transmitter release involving Ca(++).


Behavioral responses of Phormia regina (Meigen) to labellar stimulation with amino acids. Behavioral responses to labellar stimulation with 19 L-amino acids were predicted on the basis of electrophysiological responses of largest labellar hairs. With the exceptions alanine, aspartic and glutamic acids, and valine tests of these predictions confirmed that Phormia can discriminate amino acids, and that these acids may be grouped according to their effects. Electrophysiological investigation of the four exceptions was repeated and results were consistent with the behavioral data. In particular, these acids elicited previously unreported responses from the salt receptor. The discrepancies between this and earlier studies may be explainable, in part, on methodological grounds. There was evidence for response differences among hairs of different sizes and among the largest labellar hairs themselves. The significance of amino acid discrimination for the problem of protein recognition can only be speculated upon until more complete electrophysiological and nutritional information is available.


Transplacental and postnatal transmission of the hepatitis-associated antigen.


Human toxic neutrophils. 3. Metabolic characteristics.


Clinical aspects of bacteremia after manipulation of the genitourinary tract.


Ion levels and membrane potential in chick heart tissue and cultured cells. Intracellular concentrations of sodium and potassium as well as resting potentials and overshoots have been determined in heart tissue from chick embryos aged 2-18 days. Intracellular potassium declined from 167 mM at day 2 to 117-119 mM at days 14-18. Intracellular sodium remained nearly constant at 30-35 mM during the same period. The mean resting potential increased from -61.8 mV at day 3 to about -80 mV at days 14-18. The mean overshoot during the same period increased from 12 to 30 mV. P(Na)/P(K) calculated from the ion data and resting potentials declined from 0.08 at day 3 to 0.01 at days 14-18. Thus, the development of embryonic chick heart during days 2-14 is characterized by a declining intracellular potassium concentration and an increasing resting potential and overshoot. Heart cells from 7- to 8-day embryos, cultured either in monolayer or reassociated into aggregates, were compared with intact tissue of the same age. The intracellular concentrations of sodium and potassium were similar in the three preparations and cultured cells responded to incubation in low potassium medium or treatment with ouabain in a manner similar to that of intact tissue. Resting potentials and overshoots were also similar in the three preparations.


T-mycoplasmas: their growth and production of a toxic substance in broth.


Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro- -methylbenzylamine.


1,3,5(10)-Estratrien-17 -yl enol ethers and acetals. New classes of orally and parenterally active estrogenic derivatives.


Synthesis and antifertility activity of some oximinoandrostenes. 3-aza-A-homo steroids have been of interest to these authors in their efforts to develop novel progestational agents.  Because it exhibits antifertility activity both in humans and animals, 17alpha-ethynyl-19-nortestosterone (norethindrone) was chosen to undergo molecular modification.  The syntheses of a number of oximino and 3-aza-A-homoandrostenes are described in the experimental section of the article.  The progestational responses of the compounds were tested through the observation of rabbit uteri.  The capacity of a compound to inhibit fertility in rate was noted from the minimum effective dose, i.e., the amount of compound in mg/kg per day which completely suppressed litter production (compound given to both male and female).  Because of the suspicion that the oximino steroids were acting postcoitally, 17-beta-acetoxy-19-norandrost-4-en-3-one oxime was studied for its postcoital activity in rats.  The postcoital antifertility action of the compound appears to be due to lytic degeneration of zygotes and/or their rapid expulsion from the reproductive tract.  Some structure-function observations are made concerning the various compounds.


Studies with antiinflammatory oxindolecarboxanilides.


Aminobenzoic acid diuretics. 4. 4-Benzyl-5-sulfamylanthranilic acid derivatives and related 1,2-benzisothiazole 1,1-dioxides.


Diacetoxypiperidinium analogs of acetylcholine.


Hydroxyguanidines. A new class of antihypertensive agents.


Potential anti-Parkinson drugs designed by receptor mapping.


L-4'-Cyano-3-(2,2,2-trifluoroacetamido)succinanilic acid and related synthetic sweetening agents.


Solid-phase synthesis and pressor potency of (1-deamino-9-ethylenediamine)-lysine-vasopressin.


A reinvestigation of the structure of chlorguanide hydrochloride.


Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.


5-Benzoyl-1-methylpyrrole-2-acetic acids as antiinflammatory agents. 2. The 4-methyl compounds.


The aldehyde analog of indomethacin.

The aldehyde analog of indomethacin.


Hypocholesterolemic 5-methyltetrazole derivatives.


Some anticonvulsant and cardiovascular effects of substituted thiazolidones.


Synthesis and analgetic activity of the diastereomeric 8-hydroxy-6,7-benzomorphans.


Circular dichroism studies of aryl diastereoisomers. 2. Dependence of  1 L b  transition sign upon the nature of the para substituent in various chloramphenicol derivatives.


Circular dichroism studies of aryl diasteroisomers. 3. Cupra A spectra of chloramphenicol derivatives.


Electron microscopy of the esophageal ganglion complex of the gastropod pulmonate Triodopsis divesta. I. Ultrastructure of the epineurium.


On being sane in insane places.

On being sane in insane places. It is clear that we cannot distinguish the sane from the insane in psychiatric hospitals. The hospital itself imposes a special environment in which the meanings of behavior can easily be misunderstood. The consequences to patients hospitalized in such an environment-the powerlessness, depersonalization, segregation, mortification, and self-labeling-seem undoubtedly countertherapeutic. I do not, even now, understand this problem well enough to perceive solutions. But two matters seem to have some promise. The first concerns the proliferation of community mental health facilities, of crisis intervention centers, of the human potential movement, and of behavior therapies that, for all of their own problems, tend to avoid psychiatric labels, to focus on specific problems and behaviors, and to retain the individual in a relatively non-pejorative environment. Clearly, to the extent that we refrain from sending the distressed to insane places, our impressions of them are less likely to be distorted. (The risk of distorted perceptions, it seems to me, is always present, since we are much more sensitive to an individual's behaviors and verbalizations than we are to the subtle contextual stimuli that often promote them. At issue here is a matter of magnitude. And, as I have shown, the magnitude of distortion is exceedingly high in the extreme context that is a psychiatric hospital.) The second matter that might prove promising speaks to the need to increase the sensitivity of mental health workers and researchers to the Catch 22 position of psychiatric patients. Simply reading materials in this area will be of help to some such workers and researchers. For others, directly experiencing the impact of psychiatric hospitalization will be of enormous use. Clearly, further research into the social psychology of such total institutions will both facilitate treatment and deepen understanding. I and the other pseudopatients in the psychiatric setting had distinctly negative reactions. We do not pretend to describe the subjective experiences of true patients. Theirs may be different from ours, particularly with the passage of time and the necessary process of adaptation to one's environment. But we can and do speak to the relatively more objective indices of treatment within the hospital. It could be a mistake, and a very unfortunate one, to consider that what happened to us derived from malice or stupidity on the part of the staff. Quite the contrary, our overwhelming impression of them was of people who really cared, who were committed and who were uncommonly intelligent. Where they failed, as they sometimes did painfully, it would be more accurate to attribute those failures to the environment in which they, too, found themselves than to personal callousness. Their perceptions and behavior were controlled by the situation, rather than being motivated by a malicious disposition. In a more benign environment, one that was less attached to global diagnosis, their behaviors and judgments might have been more benign and effective.


Convergent projection of three separate thalamic nuclei on to a single cortical area. Three distinct sensory-motor nuclei in the thalamus project to parietal cortex in the Virginia opossum; the ventral posterior nucleus receives inputs from somatic sensory structures and projects to layers IV and III, the ventral anterolateral nucleus receives inputs from motor structures and projects to layers IV and III and inner I, and the central intralaminar nucleus receives inputs from sensory, motor, and other structures and projects to layers VI through outer I. The physiologically defined amalgamation of somatic sensory and motor cortex is correlated, therefore, with the extent of cortex that receives convergent somatic sensory and motor input from the thalamus.


Radiation effects in free-ranging pocket mice, Perognathus parvus, during the breeding season. Captive and free-ranging Great Basin pocket mice, Perognathus parvus, were exposed to ionizing radiation during the breeding season, April-June, in 1971. The values for the median lethal dose (LD(50)) at 30 days plus or minus the standard deviation were 880 +/- 14 rads and 780 +/- 27 rads, respectively, and the slopes of the survivorship curves were significantly different. These differences suggested that there was a synergism between radiation-induced and environmental sources of mortality, since the field data were corrected for natural mortality (5 percent) in the controls.


Gonadal effects of vasectomy and vasoligation. During a 28-week study, vasectomy and vasoligation of immature male Wistar rats revealed that there was a significant decrease in urinary 17-ketosteroid in the vasectomized group at week 15; at week 28 there were significant decreases in the weights of the testes of the test groups, as compared to those receiving sham operations, with maximum alterations in the vasectomized rats. Small, soft discolored testes with cysts in the cauda epididymis and vas deferens regions occurred frequently in the test groups. The output of 17-ketosteroid in the urine and the findings in the testes indicate significant alterations in the morphology and function of the testes and suggest the need for caution and extensive investigations in man before recommending vasectomy as a simple, innocuous, "physiologic" means to ensure conception control.


Collagen synthesis in vitro by embryonic spinal cord epithelium. Isolated spinal cords from chick embryos (stages 12 to 15) were incubated in vitro with radioactive proline. The proteins synthesized were fractionated by coprecipitation with added carrier collagen, followed by molecularsieve and ion-exchange chromatography. A portion of the isotopically labeled proteins were found to be collagen molecules consisting only of alpha1 chains.


Induction of choline phosphotransferase and lecithin synthesis in the fetal lung by corticosteroids. Rabbit fetuses 23 to 24 days of gestation were injected with either 9-fluoroprednisolone acetate or saline. Three days later the lungs of steroid-treated animals showed a significant increase in lecithin concentration and cholinephosphotransferase activity. In addition, lung slices from these animals incorporated more [(14)C]choline into lecithin. The rise in enzyme activity and [(14)C]choline incorporation was blocked by prior treatment of fetuses with cycloheximide but not by treatment with actinomycin D. It is proposed that the corticosteroids induce de novo synthesis of the lung enzyme, which in turn leads to increased synthesis of lecithin through the choline incorporation pathway. Furthermore, it appears that the site of regulation involves translation of messenger RNA.


Reexamination of the biochemical transfer of relational learning.


Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles. 3-Methoxy-4-hydroxyphenylglycol and normetanephrine were analyzed in daily urine specimens of a patient with manic-depressive cycles who was studied longitudinally. The quantities of these catecholamine metabolites excreted into urine were decreased during periods of depression as compared with periods of mania. Urinary excretion of 3-methoxy-4-hydroxyphenylglycol varied cyclically with a period length of approximately 20 days. Changes in this metabolite, and perhaps in normetanephrine, preceded the affective and behavioral shifts.


Food habits of early man: balance between hunting and gathering.


Newborn walking: additional data.

Newborn walking: additional data.


Suicides in the "new" community hospital.


Behavior therapy and spasmodic torticollis.


Behavioral techniques in family-oriented crisis intervention.


Recent increase in adolescent cigarette smoking. A disquieting phenomenon examined.


Indigenous therapists in a Southern black urban community.


Sleep of dry alcoholics.

Sleep of dry alcoholics.


Plasma and urinary testosterone levels in depressed men.


Catatonia. Retarded and excited types.

Catatonia. Retarded and excited types.


Disrupted 24-hour patterns of cortisol secretion in psychotic depression.


Temporal information processing in schizophrenia.


Decisions about drug therapy. 3. Selection of treatment of psychiatric inpatients.


Development of an ego profile scale.

Development of an ego profile scale.


Alcoholism and depression.

Alcoholism and depression.


Hanging and climbing functions in raccoon and sloth after total cerebellectomy.


Unusual neurologic and roentgenographic manifestations of eosinophilic granuloma.


Brain catecholamines and their metabolites in Parkinsonian patients. Treatment with levodopa alone or combined with a decarboxylase inhibitor.


Spinal cord infarction secondary to occlusion of the anterior spinal artery.


Histological evidence of optic chiasma glioma in the "diencephalic syndrome".


Polygraphic monitoring of apneic spells.


Rapid amelioration of motor aphasia.

Rapid amelioration of motor aphasia.


Essential hypernatremia. The experimental model.


Superficial stromal reactions of lower genital tract.


Amyloid tumor of the breast.

Amyloid tumor of the breast.


Modification of levodopa effect by systemic decarboxylase inhibition.


Double outlet right ventricle. Association with other cardiovascular anomalies.


Experimental oral lead toxicity in young dogs. Clinical and morphologic effects.


Methylene chloride and chronic renal hypertension.


Metastatic squamous cell carcinoma of the cervix. The role of immunology in its pathogenesis.


Letter to the editor: lithium determination of the tissue.


Familial occurrence of thymoma.

Familial occurrence of thymoma.


Recovery from a usually lethal period of hypotension. Structural alterations in surviving dogs.


Mural bacterial endocarditis of a ventricular friction lesion.


Basal cell adenoma involving the lip.

Basal cell adenoma involving the lip.


National health plans.

National health plans.


Mental care for children.

Mental care for children.


Mental health benefits under NHI.

Mental health benefits under NHI.


Staffing for hihg-quality care.

Staffing for hihg-quality care.


Industry peer review 'opens' hospital.

Industry peer review 'opens' hospital.


Lockers provide 24-hour garment service.


Trends indicate expanded administrative roles.


Convenience foods decision: yes.

Convenience foods decision: yes.


State's mental hospitals improve dietary operations.


T3 thyrotoxicosis due to metastatic thyroid carcinoma.


Integrated concentration of plasma cortisol in normal subjects.


In vitro formation of apparent covalent complexes between L-triiodothyronine and plasma protein.


Role of growth hormone in the alteration of carbohydrate metabolism induced by oral contraceptive agents.


Estimation of average times of residence, recycle and interconversion of blood-borne compounds using tracer methods.


Pulsatile patterns of gonadotropins and testosterone in man: the effects of clomiphene, with and without testosterone added.


Circadian rhythms of serum and urinary estrogens in pregnancy.


Metabolic clearance rates and metabolism of mestranol and ethynylestradiol in normal young women.


Alterations in distribution volume and biological half-life of cortisol during major surgery.


Experimental obesity in man. 3. Adrenocortical function.


Serum thyrotropin and thyroxine concentrations in patients recieving lithium carbonate.


Prolactin and somatomedin in hypopituitary patients with "catch up" growth following operations for craniopharyngioma.


The influence of fetal sex on the levels of plasma progesterone in the human fetus.


Serum and thyroid gland triiodothyronine in the human fetus.


Normal cyclical patterns of serum gonadotropins and ovarian steroids despite congenital absence of the uterus.


Anomalous postural response of plasma aldosterone concentration in patients with aldosterone-producing adrenal adenoma.


Retardation of hair regrowth, a phenomenon of senescence in C57B1-6J male mice.


Histological age changes associated with mouse parodontal tissues.


Effect of age and diapause on the mean impulse frequency and failure to generate impulses in labellar chemoreceptor sensilla of Phormia regina.


Physiological effects of an exercise training regimen upon women aged 52 to 79.


Effect of age on the contingent negative variation ina pitch discrimination task.


Thirty-five-year follow-up study of intellectual functioning.


The concept of general experience: age and strategies in guessing future events.


Studies of body image. II. Dollar values of body parts.


Voluntary association participation and life satisfaction: a cautionary research note.


Image artifacts in tomographic gamma camera systems.


Diagnosis of a pancreatic pseudocyst from the liver-spleen scan.


An interesting artifact in radionuclide imaging of the kidneys.


Cerebral death: a rapid and reliable diagnostic adjunct using radioisotopes.


Human breast milk excretion of radionuclides following administration of radiopharmaceuticals.


Analysis and correction of spatial distortions produced by the gamma camera.


The variability of early urinary excretion of  113m In.


Technetium-99m-labeled stannous ethane-1-hydroxy-1 1-diphosphonate: a new bone scanning agent.


Streamline flow in the human portal vein.


Clinical evaluation of microscintigraphy of the lacrimal drainage apparatus.


67 Ga-citrate for scanning experimental staphylococcal abscesses.


Porphyrins. XXVI. Triplet excimer quenching of free base, zinc, palladium, and platinum complexes.


Interaction between acridine orange and poly(styrenesulfonic acid).


Pseudopolyelectrolyte polyamino acids.

Pseudopolyelectrolyte polyamino acids.


Caffeine-induced catecholamine secretion: similarity to caffeine-induced muscle contraction.


Significance of skin as a site of fatty acid and cholesterol synthesis in the chick.


Studies of interferon production in Aedes albopictus mosquito cells.


Oxidation of  14 C-glycerol administered by ventriculocisternal perfusion in the dog.


The role of posture in the natriuresis of water immersion in normal man.


Penicillamine-induced cupriuria in normal subjects and in patients with active liver disease.


Coxsackievirus myocarditis: prophylaxis and therapy with an interferon stimulator.


Secretin-gastric emptying and motor activity: natural versus synthetic secretin.


The cutaneous basophil response to particulate antigens.


DNA repair synthesis and survival of repair deficient human cells exposed to the K-region epoxide of benz( )anthracene.


Effects of penicillin G on platelet aggregation, release, and adherence to collagen.


Vaccinia virus hemagglutination receptor in chickens determined by K isoantigen locus.


Body cell mass and lean body mass in the growing beagle.


Lack of opsonization potential of 11S human secretory  A.


Effect of colestipol (U-26,597A) on experimental atherosclerosis in rabbits.


Insensitivity of the sheep to prostaglandins.


Hormonal maintenance of pregnancy in hypophysectomized rats.


Effect of exercise on the plasma concentration of anorexigenic substance in man.


Prostaglandin-like substances: initiation and maintenance of rabbit testicular contraction in vitro.


Functional utilization of palmitate, octanoate, and glucose by the isolated rat heart.


Effects of LSD, pargyline and haloperidol on mammary tumor growth in rats.


Uptake of individual amino acids by the human brain.


Polymorphism in lactate dehydrogenase of skeletal muscle associated with YY sex chromosomes in medaka (Oryzias latipes).


The effect of lateral hypothalamic lesions in weanling rats bearing lesions in the ventromedial hypothalamic nuclei.


In vitro incorporation of orotic acid by spleen and liver cells of rats.


The effect of multiple lathyrogenic agents upon wound healing in rats.


The isolation of erythropoiesis regulatory factory by an electrofractionation technique combined with selective membrane permeability.


Platelet factor 4 in platelet disorders--storage location and the requirement of endogenous ADP for its release.


Pitfalls in measurement of  14 CO 2  activity from glucose-6- 14 C and two corrective procedures.


Suppression of lymphocyte blastogenesis in man following cis-platinous diamminodichloride administration.


In vitro catabolism of heterologous and homologous serum albumin by lysosomal enzymes.


Preservation of viable platelets by freezing. Effect of plastic containers.


Fetal blood volume and fetal placental blood flow in lambs.


Acid-base effects on renal organic cation transport.


The pathogenesis of neurogenic hypercholesterolemia. IV. Abnormal metabolism of chylomicronous cholesterol.


Microsomal metabolism of the hepatotoxin  -naphthylisothiocyanate (ANIT) following phenobarbital, chlorpromazine or actinomycin D treatment.


Effect on growth but not on chromosomes of the mammalian cells after treatment with three organophosphorus insecticides.


The transplacental passage of fetal leukocytes into the maternal blood.


Effects of testosterone and estradiol in vivo on hepatic cortisol metabolism in vitro.


Tolerance of delta-9-tetrahydrocannabinol in the spontaneously hypertensive rat.


Effect of cesarean section on postpartum ovulation and changes in serum LH in postopartum in rats.


Effect of perphenazine on the secretion of prolactin in vivo and in vitro.


Influence of perfusion time on norepinephrine uptake, heart rate and intracellular cations in guinea pig hearts.


Studies on the protective effect of diphenylhydantoin against alloxan diabetes in mice.


Localization of gallium-67 during embryogenesis.


Catheterization of the superior vena cava.


Cecal enlargement combined with sodium transport stimulation in rats fed polyethylene glycol.


The treatment of metastatic carcinoma of the liver by the percutaneous selective hepatic artery infusion of 5-fluorouracil.


Standards for wound healing research.

Standards for wound healing research.


Hemodynamics of venous occlusion in the canine hindlimb.


Affluence and the cowardly surgeon.

Affluence and the cowardly surgeon.


The intensive-care laboratory.

The intensive-care laboratory.


Inadvertent arterial stripping in the lower limb: problems of management.


Hepatic circulation after side-to-side portacaval shunt in dogs: velocity pattern and flow rate changes studied by an ultrasonic velocimeter.


Congenital hepatic fibrosis: report of two new cases and review of the literature.


Bacteroides liver abscess.

Bacteroides liver abscess.


Avoidance of shock and peripheral embolism during surgery of the abdominal aorta.


Limb blood flow in congenital arteriovenous fistula.


Persistence of active and passive ionic transport during low-temperature liver preservation.


Paraplegia complicating resection of aneurysms of the infrarenal abdominal aorta.


Prolonged left ventricular pressure monitoring by a catheter transducer.


Renal blood flow and perfusion pressure before and after development of renal hypertension.


Na and Cl transport across isolated proximal small intestine of the rabbit.


Relative importance of kidney and liver in synthesis of arginine by the rat.


Isoproterenol-induced stimulation of sodium absorption in perfused salivary duct.


Natriuresis and chloruresis during hydropenia in the rat.


Natriuresis and chloruresis during hydrogenia in the rat.


Renal excretion of D-tryptophan, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in rats.


Hypoxia, an adjunct in helium-cold hypothermia: sparing effect on hepatic and cardiac metabolites.


Effect of low temperature on metabolism of rat liver slices and epididymal fat pads.


-Aminobutyric acid shunt in renal ammoniagenesis.


Adrenergic activity in rat hypothalamus following extreme muscular exertion.


Inulin and mannitol distribution volumes in canine small intestinal tissues in vivo.


Time course of pulmonary vascular response to hypoxia in dogs.


A micropuncture study of Henle's thin loop in Brattleboro rats.


Major autonomic pathways to the atria and S-A and A-V nodes of the canine heart.


Effect of increased distal bicarbonate delivery on free water reabsorption in the dog.


Regional increases in mass and flow during compensatory renal hypertrophy.


Potassium and uric acid content in tissues of the silkmoth Hyalophora cecropia.


Effect of acute pulmonary edema on pulmonary arterial pressure in intact dogs.


Atrial rate response to ventricular pacing in the unanesthetized A-V blocked dog.


Enzymatic pathways of pyruvate metabolism in skeletal muscle: adaptations to exercise.


Renal arterial pressure, renin secretion, and blood pressure control in trained dogs.


Effects of acute urea infusion on proximal tubular reabsorption in the dog kidney.


Effects of a pressure load on left ventricular systolic time intervals.


Tubular absorption in the posthypoperfusion kidney during saline diuresis.


Renal functional effects of 4-pentenoic acid, an inhibitor of fatty acid oxidation.


Chronic nonspecific respiratory disease in Berlin, New Hampshire, 1961 to 1967. A follow-up study.


Klinefelter's syndrome, obesity, and respiratory failure.


Physical properties of sputum. IV. Effects of 100 per cent humidity and water mist.


The chest roentgenogram in smoking females.


Tuberculosis in student nurses at Philadelphia General Hospital.


Mycobacterium chelonei in abscesses after injection of diphtheria-pertussis-tetanus-polio vaccine.


Tuberculous bronchopleural fistula.

Tuberculous bronchopleural fistula.


Physiologic diagnosis of subclinical emphysema.


Lack of correlation between clinical background and pulmonary function tests in patients with chronic obstructive pulmonary diseases. A retrospective study of 140 cases.


The failure of indirect indices of lung elastic recoil.


Quantitative measurement of bronchial muscle in men with asthma.


The ventilation of bullae and the effect of their removal on thoracic gas volumes and tests of over-all pulmonary function.


Medical radiography with fast neutrons.

Medical radiography with fast neutrons.


Hepatic scintiscanning in fulminant hepatic failure.


Multisection tomography as an aid in the localization of intraocular foreign bodies.


Intestino-vaginal fistulae.

Intestino-vaginal fistulae.


Vascular radiology in the rat.

Vascular radiology in the rat.


Traumatic renal vein thrombosis associated with renal artery occlusion.


Radiosensitivity of capillary endothelium.


Bone marrow damage following total nodal irradiation in Hodgkin's disease patients.


A disposable automatic dispenser for air encephalography.


Oxygen, hyper- and hypobaric. Current and possible future trials.


Implications of reoxygenation.

Implications of reoxygenation.


Tourniquet hypoxia.

Tourniquet hypoxia.


Detection of skeletal metastases.

Detection of skeletal metastases.


Cerebral isotope tomography.

Cerebral isotope tomography.


Clinical experience with a "Dynacamera".


Clinical applications of gamma camera tomography.


Isotope angiography of the neck and thorax.


Experience with a gamma camera compared with a double-headed scanner.


Direct comparison of cerebral scans using a gamma camera and rectilinear scanner.


Sequential scanning of the liver and biliary tract in jaundiced patients with rose bengal  131 I.


The effect of methyl CCNU (NSC-95441) on the cellular kinetics of normal and leukemic murine tissues in vivo.


Hydroxyurea effects in the C3H mouse. I. Duodenal crypt cell kinetics.


Autoradiographic detection of DNA polymerase containing nuclei in sarcoma 180 ascites cells.


Computer simulation of growing cell populations.


Computer subtraction of background in autoradiography with tritiated thymidine.


The biology of cell death in tumours.

The biology of cell death in tumours.


AutoAnalyzer assay for serum alkaline phosphatase activity, with sodium thymolphthalein monophosphate as substrate.


Evaluation of "Dexsil 300 GC" as stationary phase in gas chromatography of triiodothyronine and thyroxine in human serum.


Semiautomated enzymatic method for determining serum triglycerides by use of the Beckman "DSA 560".


Colorimetric determination of 2,3-diphosphoglycerate in whole blood.


Use of ferric ammonium sulfate in serum cholesterol determination.


Anomalous response of macroamylase to assay temperature.


Increased activity of serum aspartate aminotransferase in the presence of added pyridoxal-5'-phosphate.


Use of gelatin-coated charcoal in digoxin immunoassay.


Trace-metal contaminants in filter paper.


The use of laboratory computers in monitoring kinetic enzyme assays.


Biological activity of a semisynthetic flavonoid, O-( -hydroxyethyl)rutoside: light-scattering and metabolic studies of human red cells and platelets.


Sensitive fluorometric method for determination of quercetin in plasma or urine.


Specific photometric determination of 5-hydroxyindoleacetic acid in urine.


Use and interpretation of common statistical tests in method-comparison studies.


Simplified, rapid measurement of ( 131 I)triiodothyronine uptake, with use of competitive charcoal adsorption.


Trimethylsilylation of malonate ester enols.


A discussion of enzyme reference materials: applications and specifications.


Cooperative survey of "SMA" analyzers in Wisconsin. A method of improving interlaboratory performance.


Application of Fe(II)-5-pyridyl benzodiazepin-2-ones to the manual or automated determination of serum uric acid.


Determination of lead in blood and urine by anodic stripping voltammetry.


Estimating correlations from single-sample distributions of measurements.


Increased aspartate aminotransferase activity of serum after in vitro supplementation with pyridoxal phosphate.


How to diminish endogenous oxalate excretion. I. Tyrosine administration.


The effect of urinary  -glucuronidase inhibition on the induction of bladder tumors with 2-acetylaminofluorene in rats.


The urinary excretion of trace metals in patients with calcium oxalate urinary stone.


Ultrastructure of the human vas deferens.


Sensory innervation of the mammalian urethra.


Bacteriuria in intestinal cconduit urinary diversion in dogs.


The effect of varying concentrations of calcium and magnesium upon calcium oxalate solubility.


A simple photoelectric system for measuring urine flow.


Ultrastructural aspects of the development of the innervation of the vesical musculature in the early human fetus.


Ureterovesical flap operation for middle and upper ureteral repair.


Hypertension due to traumatic ureteral occlusion.


Experimental psychotherapy: effectiveness of therapist response under two conditions of threat.


Moral judgments of psychotherapy clients and their parents.


Role modeling as an assessment of counselor interpersonal skills.


Social science-created Frankensteins.

Social science-created Frankensteins.


Premorbid adjustment and short-term recall in schizophrenia.


Stimulus-seeking and conservatism.

Stimulus-seeking and conservatism.


Individual differences in resistance-to-temptation behavior in adolescents: an Eysenck analysis.


Cognitive changes during acute psychiatric hospitalization.


Type of psychiatric disorder and locus of control.


Scoring agreement on the Stanford-Binet.


Examiners' scoring style, accuracy, ability and personality scores.


Parsimony and complexity as related to the diagnostic process with children.


Conspicuous psychotic behavior as a manipulative tool.


Prediction of WAIS scores from group ability tests.


On the relation between psychiatric ward atmosphere and helping behavior.


A check on the factor structure of the Opinions of Mental Illness scale.


Prediction of success for alcoholics in the Navy: a first look.


The effects of ward change on patients' psychopathology and behavior: a failure to replicate.


Comparison of children's perceptions of child care workers and therapists.


The effect of vasopressin (Pitressin) administration on sodium, potassium and urea excretion in rats with and without diabetes insipidus (DI), with a note on the excretion of vasopressin in the DI rat.


The progesterone concentrations in the peripheral plasma of the mink (Mustela vison) during pregnancy.


Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: an autoradiographic study.


Rapidly-labelled RNA in the mouse mammary gland before and during lactation.


Levels of testosterone and luteinizing hormone in plasma samples taken at 10-minute intervals in normal men.


The release of oxytocin and prolactin during parturition in the goat.


Suppression of luteinizing hormone secretion in male rats by 5 -androstan-17 -ol-3-one (dihydrotestosterone) propionate.


The effect of gonadotrophins on fluid secretion and sperm production by the rat and hamster testis.


Some aspects of changing body composition of mice during successive pregnancies and lactations.


Erythropoietin-induced changes in plasma calcium and bone marrow mitosis in the rat.


Metabolic studies in a patient with a phaeochromocytoma associated with hypokalaemia and hyperaldosteronism.


Inhibition of milk secretion by intraperitoneal injections of milk into lactating mice.


The effect of unilateral ovariectomy in the neonatal mouse on follicular development.


Discharge patterns of supraoptic and paraventricular neurones in rats given a 2 per cent NaCl solution instead of drinking water.


Lecithin-cholesterol acyltransferase and serum cholesterol esterification in obstructive jaundice.


Fabry's disease: enzymatic diagnosis of hemizygotes and heterozygotes. Alpha-galactosidase activities in plasma, serum, urine, and leukocytes.


Streptococcal infection of scabetic lesions related to acute glomerulonephritis in Trinidad.


Myocardial zinc metabolism in experimental myocardial infarction.


Dissociation of zinc excretion from other cations in man.


Concentration of iodide, pertechnetate thiocyanate, and bromide in saliva from parotid, submandibular, and minor salivary glands in man.


Biliary excretion of  3 H-digitoxin: modification by bile salts and phenobarbital.


The effects of dextrothyroxine on the kinetics of prothrombin activity: proposed mechanism of the potentiation of warfarin by D-thyroxine.


Hemolysis by diphenylsulfones: comparative effects of DDS and hydroxylamine-DDS.


A microassay for studying allergic histamine release from human leukocytes using an enzymic-isotopic assay for histamine.


Plasma heparin: a unique, practical, submicrogram-sensitive assay.


In vitro colony formation by human bone marrow cells after freezing.


Some aspects of cannabis research.

Some aspects of cannabis research.


Studies on iron absorption. I. The role of low molecular polymer in iron absorption.


Studies on iron absorption. II. Transport mechanism of low molecular iron chelate in rat intestine.


Failure of response to N 5 -methyltetrahydrofolate in combined folate and B 12  deficiency. Evidence in support of the "folate trap" hypothesis.


Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats.


The value of the gelatin infusion test in the diagnosis of pancreatic exocrine insufficiency in patients with Billroth. II. Anastomoses.


Registry request: intestinal ulcers, malabsorption, celiac disease, ulcerative ileojejunitis.


The use of "medical by-pass" in the therapy of Crohn's disease: report of a case.


Operative prevention of exsanguinating hemorrhage from varices.


Lymphotoxin in nonspecific inflammatory bowel disease lymphocytes.


Intrinsic factor secretion in the gastric juice in diabetes mellitus.


The effect of acetic acid on gastric secretion stimulated by endogenous gastrin in vagally denervated canine fundic pouches.


Prognostic implications of calcium-mediated gastrin levels in the ulcerogenic syndrome.


Surgical alteration of intestinal motility.


Failure to achieve success with remedial gastric surgery.


Scanning electron microscopy of small bowel strangulation obstruction.


Injury and repair in acute gastroduodenal ulceration.


Omental protection of intestinal anastomoses.


Operative treatment of benign gastric ulcers.


Carcinoma of the gastric stump.

Carcinoma of the gastric stump.


Gastrin release in vagally stimulated gastric acid secretion in dogs.


Comparative results of operations for duodenal ulcer. A twenty year personal experience.


Failure of operative cholangiography to prevent retained common duct stones.


Peritoneal lavage in blunt abdominal trauma.


Serosal hypofibrinolysis. A cause of postoperative adhesions.


Preoperative manometry in the choice of operations for gastroesophageal reflux.


Ribulose diphosphate oxygenase. I. Synthesis of phosphoglycolate by fraction-1 protein of leaves.


Correlation between narrow-banded ultraviolet spectra and oxygen equilibrium functions in native and chemically modified human hemoglobins.


Effects of anions and ligands on the tertiary structure around ligand binding site in human adult hemoglobin.


5-(4-Aminobutylaminomethyl)uracil, an unusual pyrimidine from the deoxyribonucleic acid of bacteriophage phiW-14.


Role of sulfhydryl groups in erythrocyte membrane structure.


Optimal conditions for amino acid incorporation by isolated rat liver mitochondria. Stimulation by valinomycin and other agents.


Demonstration of the heterogeneity of nucleoside diphosphokinase in rat tissues.


Ribulose diphosphate oxygenase. II. Further proof of reaction products and mechanism of action.


Chemical and enzymatic polymerization of 2-aminomethyl-3,3'-carboxymethyl-4,4'-( -carboxyethyl)dipyrrylmethane.


Micellar aggregation of   5 -3-keto steroids lacking a polar C-17 group and its relation to the activity and specificity of the   5 -  4 -3-ketosteroid isomerase of Pseudomonas testosteroni.


Amino acid sequences of mouse 2.5S nerve growth factor. I. Isolation and characterization of the soluble tryptic and chymotryptic peptides.


Purification of the polyenzymes responsible for tyrocidine synthesis and their dissociation into subunits.


The relation of the -amino group of trypsin to enzyme function and zymogen activation.


Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus.


Peptidylpuromycin formation on mammalian polysomes. Studies on transpeptidation and translocation.


Solvent-dependent conformations of valinomycin in solution.


Carbon framework of valinomycin and its metal ion complex in solution.


Increase in the stability of avidin produced by binding of biotin. A differential scanning calorimetric study of denaturation by heat.


A carbon-13 nuclear magnetic resonance study of nucleotide-metal interactions. Binding of manganese(II) with adenine nucleotides.


Microviscosity and order in the hydrocarbon region of phospholipid and phospholipid-cholesterol dispersions determined with fluorescent probes.


Amino acid sequences at constant and variable regions of heavy chains of monotypic immunoglubulins G and M of a single patient.


Effect of chemical modification on the rate of renaturation of deoxyribonucleic acid. Deaminated and glyoxalated deoxyribonucleic acid.


Vocational rehabilitation of the hard-core addict.


A five-year follow-up of psychiatrically disabled clients.


What's happening in hard-drug rehabilitation?


A tale of two lives.

A tale of two lives.


Medical and surgical management of enteroliths in Equidae.


The mechanism of renal glomerular capillary retention of carbon in disseminated intravascular coagulation. In rabbits, when renal glomerular capillary thrombosis was induced by an infusion of thrombin, injected colloidal carbon particles localized within glomeruli. When administered after the thrombin had been infused, carbon was attached to the surface of fibrin deposits. Carbon also attached to platelets within capillaries containing fibrin, but not to leukocytes or endothelial cells. If administered simultaneously with thrombin, the carbon was incorporated into the developing mass of fibrin. These observations demonstrate that disseminated intravascular coagulation leads to the deposition of colloidal materials from the circulating blood in regions remote from reticuloendothelial organs, and illustrate a nonimmunologic mechanism whereby foreign particles and abnormal proteins might be trapped within the renal microcirculation.


Palatability and efficacy of a powder formulation of thiabendazole and trichlorfon for horses.


Miliary bronchiolithiasis in a cat.

Miliary bronchiolithiasis in a cat.


Ectopic hyperparathyroidism in a patient with metastatic hypernephroma.


A dissociated effect of amino-glutethimide on the mineralocorticoid secretion in man.


Absorption of dietary cholesterol in man.


Choice of intravenous amino acid solutions for use after surgical operation.


Urinary excretion of quinolinic acid and other tryptophan metabolites after deoxypyridoxine or oral contraceptive administration. The urinary excretion of quinolinic acid and some other tryptophan metabolites has been determined after a 2-g L-tryptophan load in a deoxypyridoxine-treated subject, in 20 women receiving estrogen-containing oral contraceptives, in and a  control group of 12 women taking no steroids.  In both situations there were increases in the excretion of quinolinic acid and 3-hydroxyanthanillic acid, as well as 3-hydroxykynurenine and xanthurenic acid.  These changes were reversed by pyridoxine administration and are considered to reflect an inhibitory effect of estrogens and deoxypyridoxine on vitamin B6 dependent enzymes.  Although the principal enzyme of the tryptophan-nicotinic acid ribonucleotide pathway affected by imparied pyridoxal phosphate function is kynureninase, the present results are consistent with the existence of an unidentified enzyme beyond  the formation of 3 hydroxyanthranilic acid requires the coenzyme.


Dehydration and susceptibility to toxic chemicals.


Occupational x-ray exposure associated with increased uptake of rubidium by red cells.


Aerosols of lead, nickel, and cadmium: a method of generating soluble and insoluble compounds.


Diphenyl poisoning in fruit paper production: a new health hazard.


Ventilatory lung function in cement workers.


Chronic nonspecific lung disease in cement workers.


Long-term tobacco smoking and mucociliary clearance from the human lung in health and respiratory impairment.


Withdrawal of cigarette smoking: a study on tracheobronchial clearance.


Growth and metabolism of chick embryo muscle cultures. Inhibition with malathion and other organophosphorus compounds.


Heinz body hemolytic anemia associated with the use of urinary antiseptics containing methylene blue in the cat.


Prevention of streptococcic lymphadenitis in swine: effectiveness of medication with chlortetracycline and isolation from other swine in an infected herd.


Prevention of streptococcic lymphadenitis in swine: effectiveness of selected antibiotics and a modified live-GES vaccine.


Toxicity of two crude oils and of kerosine to cattle.


A sociobiological approach to the study of coronary heart disease.


False positive latex in a tropical area.


A note on the absence of 'clustering' of multiple sclerosis cases.


Analgesic consumption and impaired renal function.


Epidemiology of trigeminal neuralgia.

Epidemiology of trigeminal neuralgia.


Sulfur source for in vitro cellulose digestion and in vivo ration utilization, nitrogen metabolism, and sulfur balance.


Teat dip comparisons.

Teat dip comparisons.


Molecular weight of bovine milk casein micelles from diffusion and viscosity measurements.


Effects of long term zinc deficiency on feed utilization, reproductive characteristics, and hair growth in the sexually mature male goat.


Malignant (necrotising) otitis externa.

Malignant (necrotising) otitis externa.


Round window occlusion in otosclerosis.

Round window occlusion in otosclerosis.


Tympanoplasty: factors in post-operative assessment.


Angio-osteohypertrophy syndrome with fibrous dysplasia.


External injuries to the larynx.

External injuries to the larynx.


Hodgkins disease of maxilla.

Hodgkins disease of maxilla.


Multiple osseous metastases in hypopharyngeal carcinoma.


Sarcoma of the ear in children--two case histories.


Regional ventilation-perfusion and hypoxia in cryptogenic fibrosing alveolitis.


An evaluation of needle punch biopsy specimens in the diagnosis of diffuse lung disease.


Pulmonary function differences in normal smoking and nonsmoking, middle-aged, white-collar workers.


Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method.


The predicted normal maximal midexpiratory flow.


An autopsy study of bronchial mucous gland hypertrophy in Glasgow.


Enhancement of oxygen toxicity by the herbicide paraquat.


The tuberculin test. Effects of storage and method of delivery on reaction size.


Severe tracheal stenosis by cartilaginous ring dislocation.


Severe respiratory depression following talwin. Case report and review of literature.


Subcutaneous metastasis of an adenocarcinoma following a percutaneous pleural biopsy.


The lung in ankylosing spondylitis.

The lung in ankylosing spondylitis.


Cardiopulmonary function in   1 -antitrypsin heterozygotes exposed to severe air pollution.


Lung scanning in occupational siderosis.


Leukocyte adhesion phenomenon in pulmonary eosinophilia (tropical eosinophilia).


Coccidioidin sensitivity among Southwestern American Indians.


Light sensitivity of prepared solutions of amphotericin B.


Arterial desaturation after sodium bicarbonate therapy in bronchial asthma.


Asthma mortality.

Asthma mortality.


American Thoracic Society guidelines for inhalation therapy contract services.


Pilocarpine in the presbyope. Demonstration of an effect on the anterior chamber and lens thickness.


Factors affecting tear film breakup in normal eyes.


Mortality related to ophthalmological surgery.


Hand-held tonometers. An evaluation by medical students.


Conjunctivodacryocystorhinostomy using silicone rubber lacrimal tubes.


Presumed ocular histoplasmosis. 3. Epidemiologic characteristics of people with peripheral atrophic scars.


Conjunctival vascular pathology associated with diabetic lipemia retinalis.


Internal common punctum during dacryocystorhinostomy. Accurate localization by the irrigation and bubble technique.


Treatment of epiphora with absent lacrimal puncta.


Retinal vascular bed in heart failure. Study in cardiomyopathic hamsters.


Autoregulation of ocular blood flow.

Autoregulation of ocular blood flow.


Perkins applanation tonometer. Clinical and laboratory evaluation.


Elective ocular surgery in hemophilia.

Elective ocular surgery in hemophilia.


Nonocular hazards of photocoagulation.

Nonocular hazards of photocoagulation.


Wet snow.

Wet snow.


Vitrectomy.

Vitrectomy.


Retinal hemorrhage in newborns and organic amblyopia.


Staphylococcus epidermidis (albus) endophthalmitis. Report of two cases after cataract extraction.


Fluorescein angiography of metastatic choroidal tumors.


Subcellular localization of high and low molecular weight DNA polymerases of rat liver.


Enzymatic glucosylation of dithiothreitol by uridine diphosphate D-glucose and particulate preparations from germinating seeds of Phaseolus aureus and Pisum sativum.


Cortisol-induced changes in U.V. absorption spectra of isolated nuclei from rat liver and thymus.


Methylation of transfer RNA during transformation of human lymphocytes by phytohemagglutinin.


Apparent unbalance between the activities of 6-phosphogluconate and glucose-6-phosphate dehydrogenases in rat liver.


The phosphorylase kinase reaction on a peptide derived from glycogen phosphorylase.


Nonenzymic formation of toxic levels of methylglyoxal from glycerol and dihydroxyacetone in Ringer's phosphate suspensions of avian spermatozoa.


The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific amidohydrolase in Propionibacterium shermanii.


Does transferrin exhibit ferroxidase activity?


Aplastic anemia in Shiraz, an analysis of 50 cases with special reference to etiological agents in Southwest Iran.


A study of the intravascular dynamics of leukocytes in the miniature pig (Minnesota).


Recommendation for use of SI in clinical laboratory measurements.


Enzymes and emphysema.

Enzymes and emphysema.


Coagulation changes during termination of pregnancy by prostaglandins and by vacuum aspiration. Serial studies on coagulation factors were performed on 12 patients having termination of mid-trimester pregnancy by extra-amniotic prostaglandin F(2)alpha and 11 patients terminated by vacuum aspiration during the first trimester. A significant change in the activity of factors V, VII and X, VIII, and X, and a decrease of the prothrombin time and platelet count were found with prostaglandin termination but no such changes occurred during vacuum aspiration. These findings suggest that the coagulation system is activated during induction of mid-trimester abortion with extra-amniotic prostaglandin F(2)alpha. This is probably related to the physiological changes in the coagulation mechanism which occur by the second trimester of pregnancy. Termination of pregnancy in the mid-trimester may, however, be expected to give rise to defective blood coagulation and thromboembolic complications.


Problem of the old and the cold.

Problem of the old and the cold. A pilot winter study of body temperatures using new measuring techniques was tested on 72 volunteers aged 65 or more living in Portsmouth. The body temperatures were related to their environmental temperature and living conditions. No case of serious hypothermia was found, but the study confirms that elderly people have lower body temperatures and suggests that the coldest individuals tended to be the least aware of discomfort from the cold; this may well place them "at risk" for developing hypothermia.


A death in the family: a lay view.

A death in the family: a lay view.


Stilboestrol diphosphate in hypercalcaemia due to parathyroid carcinoma.


A death in the family: a professional view.


Where to die.

Where to die.


Supporting the patient in the home.

Supporting the patient in the home.


The social worker's role.

The social worker's role.


Nurse training.

Nurse training.


Continuity of care.

Continuity of care.


Local government services.

Local government services.


Minors and medical experiments.

Minors and medical experiments.


Treatment of status asthmaticus.

Treatment of status asthmaticus.


Infertility after the pill.

Infertility after the pill.


Radiation safeguards.

Radiation safeguards.


Barbiturates and methyldopa metabolism.

Barbiturates and methyldopa metabolism.


Graphic records in labour.

Graphic records in labour.


Doctor disqualified from driving.

Doctor disqualified from driving.


Uganda Asians.

Uganda Asians.


Care of the dying.

Care of the dying.


Perinatal therapeutics and toxicology.

Perinatal therapeutics and toxicology.


Action of some drugs on performance time in mice.


When the stroke patient draws a picture: a clue to disability.


Treatment of carotid sinus syncope with demand pacemaker.


When pain has more than one cause.

When pain has more than one cause.


The Framingham Study. Cigarettes and the development of intermittent claudication.


Prevention of deep vein thrombosis.

Prevention of deep vein thrombosis.


Accumulation of  3 H-glycine in interneurons of the cat spinal cord.


Effects of corneal environment on oxygen tension in the anterior chambers of rabbits.


Corneal and scleral distensibility ratio on enucleated human eyes.


Lateral inhibition and the VER in the central field of an amblyopic subject.


Experimental cataract and wound healing in mouse lens.


Fourier analysis of vision.

Fourier analysis of vision.


Studies on the cornea. 8. Reversibility of the effects of in vitro perfusion of the rabbit corneal endothelium with calcium-free medium.


Amino acid sequence of the threonine-containing mureins of coryneform bacteria. In a study of the mureins of coryneform bacteria (Arthrobacter, Brevibacterium, Cellulomonas, Corynebacterium, Erysipelothrix), 21 threonine-containing strains were found. In several of the strains the amino acid and amino sugar composition of the murein was muramic acid (Mur), glucosamine (GlcNH(2)), d-Glu, l-Lys, l-Thr, and Ala in a molar ratio of 1:1:1:1:1:4 or 5, and in several other strains it was Mur, GlcNH(2), d-Glu, l-Lys, l-Thr, Ala, and l-Ser in a molar ratio of 1:1:1:1:1:3:1. The amino acid sequence of the mureins was determined by analyzing the oligopeptides derived from partial acid hydrolysates. It was shown that there were five different murein types. The peptide subunits attached to the muramic acid are the same, namely l-Ala-d-GluNH(2)-l-Lys-d-Ala. In one strain, the alpha-carboxyl group of d-Glu is substituted by d-alanine amide. The interpeptide bridges of the different types consist of the peptides l-Ala-l-Thr-l-Ala, l-Ala-l-Thr, l-Ala-l-Ala-l-Thr, l-Ala-l-Ala-l-Ala-l-Thr, or l-Ala-l-Thr-l-Ser which are bound through their C-termini (l-Ala, l-Thr, l-Ser) to the epsilon-amino group of l-Lys of one peptide subunit and by their N-termini (l-Ala) to the C-terminal d-Ala of an adjacent peptide subunit. Determination of the N- and C-terminal groups in the mureins showed that about 15 to 30% of the interpeptide bridges are not cross-linked.


Normal anatomy of the human cardiac conduction system.


"Paradoxical" septal motion by echocardiography in a patient with normal right heart hemodynamics.


Acquired hyperoxaluria and intestinal disease. Evidence that bile acid glycine is not a precursor of oxalate.


Alcoholism and the family.

Alcoholism and the family.


Laboratory and clinical observations with a two-column plasma catecholamine assay.


The physician and the environment.

The physician and the environment.


Peer review: problems and potentials. Panel discussion on peer review.


Gas gangrene of the extremities.

Gas gangrene of the extremities.


A statewide communication system to support a regional program for emergency health care delivery in Maryland.


Current aspects of digitalis therapy.

Current aspects of digitalis therapy.


Osteoporosis.

Osteoporosis.


VD gonorrhea study.

VD gonorrhea study.


Quiet clues to bacterial endocarditis in children.


How to answer our critics.

How to answer our critics.


From the medical examiner's files.

From the medical examiner's files.


An unusual case of spontaneous pneumocephalus.


A plea for quality in clinical articles.


Nuclear mediquiz. What's your diagnosis?


Treatment of drug addicts in private practice.


How to make a psychiatric diagnosis.

How to make a psychiatric diagnosis.


Two minutes with diabetes. "How much insulin must I finally use"?


Why and how to aspirate "macro" cysts of the breast.


The Doppler ultrasonic flowmeter. Report of its use for diagnosis of peripheral vascular disease in the smaller community hospital.


Lung cancer survival. The Ohio State University Hospitals.


Amniotic bands as a cause of fetal deformity. Case report with discussion.


E.N.T. case of the month.

E.N.T. case of the month.


Milk-alkali syndrome. Report of a case presenting with "respiratory failure".


Anomalous origin and course of the left coronary artery. Report of a case.


Drug dosage in renal failure.

Drug dosage in renal failure.


Massive autoagglutination, hemolysis, and hypergammaglobulinemia triggered by adrenocortical steroids--a case report.


Renal potassium-wasting of unknown cause in a clinical setting of chronic potassium depletion: report of a case.


Virilization superimposed on Turner's syndrome: cytogenetic studies of a gonadal tumor in a patient with XO-XY mixed gonadal dysgenesis.


Hypoplastic anemia, Friedreich's ataxia and chromosomal breakage: case report and review of similar disorders.


Autosomal recessive sensorineural deafness: a comparison of two kindreds.


The leavening of a private medical school.


The malnutrition of parasitism in Egypt.


Role of the adrenal cortex in hypertension.


Role of insulin in amino acid metabolism.


Local hypothermia in the treatment of acute injuries of the spinal cord.


Antrectomy or pyloroplasty? A prospective study with selective gastric vagotomy.


Morphology of cervix uteri of Rodentia, Carnivora and Artiodactyla.


Early stages in postnatal development of the adrenal gland.


glandular acini in the wall of the lower part of the domestic cat vagina.


A study of sex-determined characteristics of the hip bones in pathologically deformed female pelves using the method of Sauter and Privat.


A soft Epon for the rotary microtome.

A soft Epon for the rotary microtome.


Functional anatomy of the nose and accessory nasal sacs in the teleost Channa punctatus Bloch.


Undertreatment of medical inpatients with narcotic analgesics.


Intermittent intravenous procaine amide to treat ventricular arrhythmias. Correlation of plasma concentration with effect on arrhythmia, electrocardiogram, and blood pressure.


Arthropathy in sickle-cell disease.

Arthropathy in sickle-cell disease.


Effects of induced fever on sulfobromophthalein kinetics in man.


Ketoacidosis associated with alcoholism in nondiabetic subjects.


The clinical significance of hypouricemia.


Idoxuridine in herpes simplex virus (type 1) encephalitis. Experience with 29 cases in Michigan, 1966 to 1971.


Scanning of the hepatic blood pool in the differential diagnosis of space-occupying lesions of the liver. With emphasis on amebic abscess.


Severe allergic pneumonitis from hydrochlorothiazide.


Conversion to problem-oriented records in an established practice. A timed study.


Diseases, dichotomies, and detail men.

Diseases, dichotomies, and detail men.


A view of modern Chinese medicine. Observations by a Shanghai-born physician during his recent visit after 22 years of absence.


Spiritus frumenti strikes another sour note.


Statement on hypoglycemia.

Statement on hypoglycemia.


The gift from the poor to the rich.

The gift from the poor to the rich.


Simultaneously administered virus vaccines.


Brucella antigen.

Brucella antigen.


Neutrophilic reduction of NBT dye: acquired defect.


Sepsis and sloppy surgery.

Sepsis and sloppy surgery.


Anaerobic liver abscess: medical treatment.


Aspergillosis.

Aspergillosis.


Dispensing sample drugs.

Dispensing sample drugs.


Use of diphenylhydantoin.

Use of diphenylhydantoin.


Intravenous L-thyroxine.

Intravenous L-thyroxine.


Phenformin and pancreatitis.

Phenformin and pancreatitis.


Quinidine and lupus-like syndrome.

Quinidine and lupus-like syndrome.


Anti-DNA antibodies: specificity.

Anti-DNA antibodies: specificity.


Anticonvulsant therapy and vitamin D.

Anticonvulsant therapy and vitamin D.


Variant angina pectoris.

Variant angina pectoris.


Renal adenocarcinoma: long survival.

Renal adenocarcinoma: long survival.


Urea therapy in sickle-cell disease.

Urea therapy in sickle-cell disease.


Antimitochondrial antibody in diagnosis of liver disease.


Evaluation of medical residents.

Evaluation of medical residents.


Promotion of gerontology.

Promotion of gerontology.


Observations of experimental retinal detachment.


Munchausen patient.

Munchausen patient.


Fluorescein angiography of grouped pigmentation of the retina.


Hyperbaric air and corneal vascularization.


Systemic pilocarpine toxicity in the treatment of angle closure glaucoma.


The intraocular penetration of chloramphenicol succinate in rabbits.


Gangrene of the eyelids.

Gangrene of the eyelids.


Management of adult patients with large angle amblyopic exotropia.


Lens capsule change after intraocular copper.


Adrenergic modulation of basal insulin secretion in man.


Pancreatic compartmentalization of insulin. Evidence for pituitary control.


Characterization of glucose metabolism in the isolated rat heart during fetal and early neonatal development.


Gluconeogenesis in renal cortical tubules. Effect of phenformin.


Hyperglycemia in Washoe and Northern Paiute Indians.


Comparison of juvenile diabetics with positive and negative organ specific antibody titers. Evidence for genetic heterogeneity.


Effects of amino acids, epinephrine and heparin upon the radioimmunoassay of insulin in plasma.


Medicated feed as a preventive for pneumonia in California range lambs.


Two cervical reflexes in the horse.

Two cervical reflexes in the horse.


Intravenous catheter placement for fluid therapy and for central venous pressure measurements in small animals.


Owner education in the treatment of pannus.


Hyphema caused by an intraoral foreign body in a dog.


Pseudohyperparathyroidism in the dog.

Pseudohyperparathyroidism in the dog.


7-Methyl-7-hexadecenoic acid: isolation from lipids of the ocean sunfish Mola mola (Linnaeus) 1758.


Circadian rhythm of fatty acid desaturation in mouse liver.


Dipyrone and aminopyrine--for relief of fever.


Sulfated bile acid in urine of patients with hepatobiliary diseases.


Ascarosides of the ovaries and eggs of Ascaris lumbricoides (Nematoda).


Synergism of acid and bile salts in the production of experimental esophagitis.


Bile esophagitis.

Bile esophagitis.


The case report in surgical literature.

The case report in surgical literature.


Cancer of the colon and rectum: comparison of the results of three groups of surgeons using different techniques.


Colon cancer and surgical aggressiveness.


Changes in the lipid metabolism of mice with lethal Staphylococcus aureus septic shock.


Orthopedics in Tunisia--1971.

Orthopedics in Tunisia--1971.


Assay of fluorescent glucosides in the human lens.


Diurnal variation in corneal thickness.

Diurnal variation in corneal thickness.


A preliminary report on the amino acid composition of the pseudo-exfoliation material (PE material).


The effect of retinol on the lysosomal enzymes of bovine retina and pigment epithelium.


Some biochemical observations on a primary retinal degeneration in sheep.


The interaction of the lens and the vitreous. II. The influence of the vitreous on lens trauma, water and electrolyte balance and osmotic stress.


Experimental allergic chorioretinitis in rabbits following immunization to homologous retina.


The neuraminidases of rat eyes.

The neuraminidases of rat eyes.


Hepatic handling of unconjugated dyes in the Dubin-Johnson syndrome.


Cerebral venous thrombosis in ulcerative colitis.


Afferent-efferent loop intragastric intussusception: diagnosed by gastroscopy.


Disappearance of deoxycholic acid after ileal resection.


Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. II. The insulin test after highly selective vagotomy.


The Berkson principle versus the Mainland-Cornfield principle.


Identity and properties of gastric lipase.


Inhibitory innervation of the gut.

Inhibitory innervation of the gut.


Serial studies of gastric secretion in patients after highly selective (parietal cell) vagotomy without a drainage procedure for duodenal ulcer. I. Effect of highly selective vagotomy on basal and pentagastrin-stimulated maximal acid output.


Serum and tissue gastrin concentrations in patients with carcinoma of the stomach.


Distribution of human colonic lymphatics in normal, hyperplastic, and adenomatous tissue. Its relationship to metastasis from small carcinomas in pedunculated adenomas, with two case reports.


Patterns of bile acids and microflora in the human small intestine. I. Bile acids.


Physiological characteristics of the human pyloric sphincter.


Effect of secretin and cholecystokinin on the transport of electrolyte and water in human jejunum.


Stimulation of colonic secretion of water and electrolytes by hydroxy fatty acids.


Lysosomal defect of hepatic copper excretion in Wilson's disease (hepatolenticular degeneration).


The effect of alternate-day prednisone on the white blood count in children with chronic asthma.


Some uses of dirty words by children.

Some uses of dirty words by children.


Juvenile manic-depressive illness. Clinical and therapeutic considerations.


Follow-up study of relationships between family situation and bronchial asthma in children.


The child and the seriously disturbed parent. Treatment issues.


The peek-a-boo game. A evolution and associated behavior, especially bye-bye and shame expression, sduring the second year.


The children of drug users.

The children of drug users.


Youth who use drugs. Psychodynamic diagnosis and treatment planning.


Heroin addiction in an adolescent population.


Treatment of two silent adolescent girls.


Dream conception and reality testing in children.


Observations on the relationship of emotional and cognitive development. A psychiatric contribution to compensatory education.


The effect of experimental diabetes mellitus and insulin replacement on hepatic ultrastructure and protein synthesis. The following study was conducted in order to define the specific alterations in hepatic ultrastructure responsible for the decrease in hepatic protein synthesis associated with experimental diabetes. Rats received intravenous alloxan (70 mg/kg) and 48 h later were either sacrificed or given insulin for 1, 2, 4, 6, or 24 h. Specimens for electron microscopic evaluation and morphometric analysis were taken from the same livers used to isolate ribosomes for measurement of in vitro protein synthesis. Our results show that hepatocytes from animals with untreated alloxan diabetes show varying degrees of disorganization and loss of rough endoplasmic reticulum (RER) which is directly related to the severity of the alloxan diabetes. A significant correlation existed between the severity of ultrastructural changes as judged by the loss of both membrane and polysome components of the RER and degree of inhibition of protein synthesis (P < 0.001). Abnormalities of hepatic ultrastructure and protein synthesis were reversed within 24 h of insulin administration. The data are consistent with the view that it is the relative decrease in hepatic polysomes that results from the loss of RER in alloxan diabetes that is responsible for the decrease in hepatic protein synthesis.


Proximal and distal tubular function in salt-deprived and in salt-loaded deoxycorticosterone acetate-escaped rats. Proximal and distal tubular function was compared with urinary excretion in rats after chronic administration of salt and deoxycorticosterone acetate (DOCA) or during salt deprivation. DOCA rats excreted significantly more sodium than did salt-deprived rats. Measurements of tubular fluid to plasma (TF/P) inulin ratios and concentrations of sodium and potassium in quantitative, timed collections, related to measured tubular length, allowed calculation of absolute reabsorption of fluid and ions in the different nephron segments. Proximal transport was not reduced in DOCA-treated rats compared with salt-deprived animals; in distal tubule the former group reabsorbed more sodium and secreted less potassium than the latter. Calculation of sodium transport in loop of Henle as the difference in flow between the end of the proximal convolution and the beginnings of the distal tubule indicated no inhibition of reabsorption in DOCA animals. Comparison of end-distal tubular flow with simultaneous urinary excretion suggested that sodium load was not the determining factor of enhanced natriuresis in DOCA-treated animals. The data are interpreted as indicating that DOCA-escape in the rat is associated with specific alteration of sodium transport in the collecting duct system.


Pathogenesis of postprandial hyperlipemia in rats fed ethanol-containing diets. To study the mechanism of the increase in serum lipoproteins which occurs in rats fed alcohol chronically, and especially to assess the role of the intestine, the effects of acute and chronic ethanol administration on lymph and plasma lipids were compared in rats with and without intestinal lymph fistulae. In rats not previously given alcohol, the administration of one dose of a diet containing ethanol (3 g/kg) produced a significant increase in lymph flow, lipid output, and incorporation of dietary fat into lymph lipids when compared with the effects of a control diet containing isocaloric carbohydrate. However, no hyperlipemia developed after ethanol. By contrast, previous feeding of ethanol for several weeks modified the acute effects of ethanol on both lymph and serum lipids. Compared with control animals pair-fed with isocaloric carbohydrate-containing diets, rats which had been fed a diet with 36% of total calories as ethanol for 3-4 wk developed postprandial hyperlipemia when given a single dose of the ethanol-containing or even the ethanol-free diet. This was associated with an increased incorporation of labeled dietary fat and of intravenously injected [(3)H]lysine into plasma lipoproteins of d < 1.006. However, postprandial lymph flow and lipid output were not higher in rats fed alcohol chronically than in their pair-fed controls. Moreover, when rats with lymph fistulae were given intravenous (i.v.) infusions of lymph lipids (to substitute for the diverted intestinal lymph), the ethanol-fed animals still developed hyperlipemia. Incorporation of i.v. lysine into d < 1.006 plasma lipoproteins also remained significantly increased. Thus, under these conditions, alcoholic hyperlipemia does not result from changes in intestinal lymph lipids. Two main factors appear to be involved; the acute effects of ethanol on hepatic lipid metabolism and the development of an increased capacity for lipoprotein synthesis during chronic ethanol feeding. The latter most likely occurs in the liver and it is postulated that it is linked to the associated changes in the hepatic endoplasmic reticulum.


Hemoglobin olympia ( 20 valine leads to methionine): an electrophoretically silent variant associated with high oxygen affinity and erythrocytosis. In a family with erythrocytosis, electrophoretic and chromatographic studies failed to demonstrate a hemoglobin variant. However, the oxygen dissociation curves of affected individuals were shifted to the left of normal and this shift persisted when oxygen equilibria were studied in 2.3-diphosphoglycerate-stripped hemolysates. A mutant hemoglobin was evidently present in the red blood cells of the affected persons and was responsible for the increased oxygen affinity and erythrocytosis. Specific staining of tryptic peptide maps of beta-chains from the propositus showed that peptide betaT(3) was positive for a sulfur-containing amino acid. Amino acid analysis yielded a composition identical to that of normal betaT(3), except that there were 2.6 residues of valine and 0.4 residues of methionine (normal composition: Val = 3.0, Met = 0). This suggested that the beta-chains of affected individuals consisted of a mixture of two kinds of chains, 40% of which had a methionyl residue in betaT(3). Structural studies of isolated cyanogen bromide fragments demonstrated unequivocally that, in the abnormal beta-chains, valine in position 20 is replaced by methionine. The new hemoglobin mutant is designated hemoglobin Olympia (beta20 (B2) valine --> methionine).


Vertical distributions of pulmonary diffusing capacity and capillary blood flow in man. In six normal upright subjects, a 100 mol bolus-composed of equal parts of neon, carbon monoxide, and acetylene (Ne, CO, and C(2)H(2))-was inspired from either residual volume (RV) or functional residual capacity (FRC) during a slow inspiration from RV to total lung capacity (TLC). After breath holding and subsequent collection of the exhalate, diffusing capacity and pulmonary capillary blood flow per liter of lung volume (D(L)/V(A) and Q(C)/V(A)) were calculated from the rates of CO and C(2)H(2) disappearances relative to Ne. The means: D(L)/V(A) = 5.26 ml/min x mm Hg per liter (bolus at RV), 6.54 ml/min x mm Hg per liter (at FRC); Q(C)/V(A) 0.537 liters/minute per liter (bolus at RV), 0.992 liters/minute per liter (at FRC). Similar maneuvers using Xenon-133 confirmed that, during inspiration, more of the bolus goes to the upper zone if introduced at RV and more to the lower, if at FRC. A lung model has been constructed which describes how D(L)/V(A) and Q(C)/V(A) must be distributed to satisfy the experimental data. According to this model, there is a steep gradient of Q(C)/V(A), increasing from apex to base, similar to that previously determined by other techniques-and also a gradient in the same direction, although not as steep, for D(L)/V(A). This more uniform distribution of D(L)/V(A) compared with Q(C)/V(A) indicates a vertical unevenness of diffusing capacity with respect to blood flow (D(L)/Q(C)). However, the relative degree of vertical unevenness of D(L)/V(A) compared with Q(C)/V(A) can account only in part for previous observations attributed to the inhomogeneity of D(L)/V(A) and Q(C)/V(A). Thus, a more generalized unevennes of these ratios must exist throughout the lung, independent of gravitation.


Interactions of the classical and alternate complement pathway with endotoxin lipopolysaccharide. Effect on platelets and blood coagulation. The contributions of the classical and alternate pathways of complement activation to the biological effects of endotoxin have been examined in the guinea pig, with particular reference to thrombocytopenia, leukopenia, and the development of the hypercoagulable state. Injection of endotoxin into normal guinea pigs led to a 95% fall in the level of circulating platelets within 15 min as well as a fall in circulating granulocytes. C4-deficient guinea pigs, known to have a complete block in the activity of the classical complement pathway, but with the alternate pathway intact, sustained no fall in platelets. The development of granulocytopenia proceeded normally. Endotoxin did activate the alternate complement pathway in C4D guinea pigs, as evidenced by the fall in C3-9 titers. With restoration of serum C4 levels, endotoxin-induced thrombocytopenia was observed in C4D animals. Thus, function of the classical complement pathway was an absolute requirement for the development of thrombocytopenia. Experiments performed in cobra venom factor (CVF)-treated normal guinea pigs, with normal levels of C1, C4, and C2, but with less than 1% of serum C3-9 demonstrated the importance of the late components in the development of thrombocytopenia but not leukopenia.C4-deficient guinea pigs had normal clotting times demonstrating that C4 was not required for normal clotting. In addition, development of the hypercoagulable state, evidenced by a marked shortening of the clotting time, was not observed on injection of endotoxin into C4D animals. Therefore, development of the hypercoagulable state paralleled the development of thrombocytopenia and required function of the classical complement pathway. Again, the importance of the late components of complement was emphasized by the failure of CVF-treated normal animals to develop hypercoagulability. These results demonstrate that endotoxin is capable of activating both the classical and alternate complement pathways in guinea pigs but that function of the classical pathway is an absolute requirement for the development of thrombocytopenia and the hypercoagulable state.