Lack of response in primary auditory neurons to visual stimulation.


Histometric evaluation of branches of peroneal nerve: technique for combined biopsy of muscle nerve and cutaneous nerve.


Adaptation in a simple neurone model compared to that of spinal motoneurones.


The action of 5-hydroxytryptamine antagonists and precursors on bulbospinal facilitation of spinal reflexes.


Amygdala unit activity changes related to a spontaneous blood pressure increase.


The depression of brain stem neurones by taurine and its interaction with strychnine and bicuculline.


Regional distribution of histamine in human brain.


5-hydroxyindoleacetic cid in spinal fluid: relative contribution from brain and spinal cord.


Perinatal brain DNA in the normal and growth hormone-treated rat.


On the innervation of the human fetal pineal gland.


Dopamine histofluorescence: restoration in mammalian brain tissues prepared several hours post mortem.


An experimental light and electron microscopic study of cerebellorubral projections in the opossum, Didelphis marsupialis virginiana.


Respiratory failure and airway management in congenital cardiovascular diseases. Some practical observations.


Removal of aspirated foreign bodies by inhalation and postural drainage. A survey of 24 cases.


Gangrene of the extremities in a newborn premature infant. Report of a case associated with pulmonary hyaline membrane disease.


Epidemiologic significance of the sporadic case of tuberculosis.


Typhoid and old lace, a grandmother carrier.


Plague as seen in South Vietnamese children. A chronicle of observations and treatment under adverse conditions.


Severe neonatal illness associated with Echo 9 virus infection.


Central nervous system infections in hydrocephalus or myelodysplasia. Factors which influence mortality and recovery.


Thrombocytopenia following measles-mumps-rubella vaccination in a one-year-old infant.


Vomiting, dehydration, and shock in a baby boy.


Intrapericardial teratoma. A curable cause of cardiac tamponade in infancy.


Influence of polynucleotides on poly (adenosine diphosphate ribose) synthetase activity of rat liver.


The molecular weight of rabbit globin messenger RNA's.


The translation of vaccinia virus messenger RNA in animal cell-free systems.


On the formation of biliverdin during photooxygenation of bilirubin in vitro.


Cyclic adenosine 3',5'-monophosphate dependent protein kinases in rat kidney.


The point of convergence of sequential double reciprocal plots as a criterion of bireactant enzyme kinetic mechanisms. Evaluation of the yeast hexokinase reaction.


Paralytic dysphonia. A case presentation.


Spectral noise levels and roughness ratings for vowels produced by males and females.


Glottal activity and intraoral pressure during stop consonant productions.


Lingual preference among children.

Lingual preference among children.


Perceptual skills in clinical management of nasality.


Reduction of stuttering under experimental social isolation. The role of adaptation effect.


Acoustic study of register equalization in singing.


Vocal intensity in the modal and falsetto registers.


The source spectrum in professional singing.


Vocal change associated with the use of atypical pitch and intensity levels.


Clinical experience with a simple test for the detection of bacterial deconjugation of bile salts and the site and extent of bacterial overgrowth in the small intestine.


Intestinal malabsorption in folate-deficient alcoholics.


Dermal and epidermal ridge atrophy in celiac sprue.


Genetics of primary adult lactase deficiency.


Effects of an elemental diet in healthy volunteers.


Effects of an elemental diet on the pancreatic proteases in the intestine of the mouse.


Influence of secretin and cholecystokinin on intestinal alkaline phosphatase secretion.


Effect of pentagastrin on canine bile flow.


Torus hyperplasia of the pyloric antrum presenting as a gastric pseudotumor.


Assessment of gastroesophageal junction.


Cystic dilation of the intrahepatic biliary tree (Caroli's disease)--a suggested treatment.


The importance of the nasal septum in facial development.


Recording of Forgács's photonystagmographic method.


A new operation for bilateral abductor paralysis.


Atrophic rhinitis. A new curative surgical treatment (middle turbinectomy).


Neurilemmoma of the maxillary antrum.

Neurilemmoma of the maxillary antrum.


A case of tonsillar localization of sarcoidosis.


An unusual case of foreign body perforation of the oesophagus.


Adaptation to a masking stimulus.

Adaptation to a masking stimulus.


Contribution of the crystalline lens to the spherical aberration of the eye.


Visual acuity as a function of exposure duration.


Spectral sensitivity by constant CFF: effect of chromatic adaptation.


Visibility of structured and unstructured images.


Effect of centrifugation and repeated washing on the fertilizing capacity of fowl spermatozoa.


Some fine structural features of epididymal cells in an edentate, Dasypus novemcinctus mexicanus.


The effect of a copper-releasing intrauterine device on sperm penetration in human cervical mucus in vitro.


Transferrin variation between mother and fetus in the marsupial, Macropus eugenii.


Distribution of frozen-thawed spermatozoa in the reproductive tract of gilts at different time intervals after insemination.


Reproductive decline in aged female rats.


Histochemical localization of hydroxysteroid dehydrogenases in the maxillary glands of pigs.


Blastocyst transfer study in the senescent golden hamster.


Effects of cyproterone acetate on the adenohypophysial cells of male rats.


Androgenization of the female rat with androstenediol.


The development of mouse blastocysts injected with, or cultured in, trypan blue solution.


Relationships between fetal weight, placental weight and maternal placental circulation in the rabbit at different stages of gestation.


The sequence of changes in prepubertal male rat serum testosterone following intravenous injection of rat LH.


Observations on the permeability properties of the egg membranes of the marsupial, Trichosurus vulpecula.


Aminopeptidases of rat testis. I. Fractionation and characterization.


Postcoital contraceptive effects of medroxyprogesterone acetate and oestrone in rats.


The effect of feed level during the oestrous cycle on ovulation, embryo survival and anterior pituitary LH potency in the gilt.


Proteins of the seminiferous tubule fluid in man--evidence for a blood-testis barrier.


Effect of ovariectomy and constant dark on the weight of reproductive and certain other organs in the female vole, Microtus montanus.


The carbohydrates of buffalo and goat semen.


Symposium on tympanoplasty. I. Results of modified type V tympanoplasty.


Subglottic hemangioma in infants.

Subglottic hemangioma in infants.


Symposium on tympanoplasty. 3. Tympanoplasty: ossicular chain reconstruction.


Ataxia secondary to labyrinthine fistula.


Cryosurgery for the treatment of chronic rhinitis.


Specific vessel ligation for epistaxis: survey of 60 cases.


Symposium on maxillo-facial trauma. 3. Pitfalls in the management of zygomatic fractures.


Mass spectrometric observations of skin flap physiology.


Symposium on maxillo-facial trauma. IV. Pitfalls in the treatment of mid-facial trauma.


Temporal bone fractures: three identical cases of lateral middle ear fractures with facial nerve injury and conductive hearing loss.


Audiometry and tympanometry in relation to middle ear effusions in children.


Respiratory care. Roles of allied health professionals.


Geographical uniformity of protein polymorphisms.


Comparison between mice chimaeric and heterozygous for the X-linked gene tabby.


Ancient chromosomal polymorphism in Hawaiian Drosophila.


Hypotaurine: regulation of production in seminal vesicles and prostate of guinea-pig by testosterone.


Basilar membrane correlates of the combination tone 2f 1 -f 2 .


Relationship between protein synthesis and RNA content in skeletal muscle.


Pituitary inhibition of pregnancy.

Pituitary inhibition of pregnancy.


The expression of female sex-limited characters in the male.


IQ evoked responses and Fourier analysis.


New aspects of Salmonella infection in broiler production.


The unexpected location of a gene conferring abnormal radiation sensitivity on phage T4.


Co-carcinogenic effect of progesterone on 20-methylcholanthrene induced cervical carcinoma in mice.


Evidence for an advanced plio-pleistocene hominid from East Rudolf, Kenya.


Influence of sodium, potassium and chloride ions on the intracellular responses of turtle photoreceptors.


Organic mercury compounds in coastal waters.


Movement of sodium ions associated with the nerve impulse.


Currents related to movement of the gating particles of the sodium channels.


Contractile effects of a calcium ionophore.


Active transport of L-dopa in the intestine.


Chimaeras and the forbidden-clone theory of self-tolerance.


Event related slow potential changes in human brain stem.


Dislocations in tobacco mosaic virus.

Dislocations in tobacco mosaic virus.


A critique of McClare's quantum mechanical muscle model.


Hyperfiltration streaming potential as a probe of water structure in membranes.


Parthenogenesis in the mouse.

Parthenogenesis in the mouse.


Orientation-sensitive after-effects or dichoptically presented colour and form.


Dietary cholesterol, sex and scurvy in guinea-pigs.


Mortality rate in male and female guinea-pigs on a scorbutogenic diet.


Electrostatic forces in some hapten-antibody reactions.


Growth of abnormal cells.

Growth of abnormal cells.


Renal blood flow in a diving trained sea lion.


Increased activity of the peripheral sympathetic nervous system: induction of choline acetyltransferase in the preganglionic cholinergic neurone.


The effect of intravenous glucagon on plasma amino acids in the newborn.


Transfer across perfused human placenta. II. Free fatty acids.


Genetic and environmental influences on digital dermatoglyphics in congenital rubella.


The American Pediatric Society, Inc. and The Society for Pediatric Research: combined program and abstracts. Annual meeting. The San Francisco Hilton Hotel, San Francisco, California, May 17-19, 1973.


The development of specific responses of the exocrine pancreas to pancreozymin and secretin stimulation in newborn infants.


Studies on ciliary dyskinesia factor in cystic fibrosis. I. Bioassay and heterozygote detection in serum.


Colorimetric determination of corticosteroids using ammonium molybdate. 1.


An approach to teaching behavior modification principles to parents.


A note on a "new" method of studying change.


A population dynamics survey in Lagos, Nigeria.


Pilot study with cyclobenzaprine in idiopathic Parkinsonism.


Psychiatric disorders in East European refugees now in Australia.


The probenecid test in Parkinson's disease.


Manipulation of sexual behaviour by anti-androgens.


Cyproteronacetate in sexualogical outpatient practice.


Recurrent vital depressions. A follow-up study of 56 female and 28 male patients.


The quality of drug advertisements in two Finnish medical journals. A comparison between psychotropic and other drug advertisements.


What happens after schooling. Notes on post-institutional socialization in the health occupations.


Efficacy of air bags--a pilot study on cadavers.


Depletion of fats from the brown adipose tissue cells of rats dead from cold exposure.


Aspiration biopsy of intrathoracic lesions.


How to refer a reluctant patient to a psychiatrist.


A simplified approach to hypertension.

A simplified approach to hypertension.


Neurogenic bowel management.

Neurogenic bowel management.


Emergency care of the trauma patient.

Emergency care of the trauma patient.


Parenteral fluid therapy in infants and children.


Basal cell and squamous cell carcinoma of the skin.


Reversible mesenteric vascular occlusion associated with oral contraceptives. A case of mesenteric vascular occlusion is detailed.  The 30-year-old female had abdominal pain, bloody diarrhea, and small bowel changes seen on x-ray.  She had begun taking the oral contraceptive Ovral (.5 mg norgestrel, .05 mg ethinyl estradiol) 3 years prior to hospital admission.  Symptoms began to disappear when her oral contraception was discontinued on the ninth hospital day.  Over the next 5 days abdominal signs and symptons subsided progressively.  A follow-up small bowel series showed complete disappearance of previous abnormalities.  In the differential diagnosis of acute abdominal pain progressing to bloody diarrhea, especially in young women or oral therapy, acute vascular insult with small bowel ischemia must be considered.


Disseminated lymphoma involving the stomach. Correlation of endoscopy with directed cytology and biopsy.


Relation of the magnitude of blood enzyme elevation to severity of exocrine pancreatic disease.


Alteration of electrical and motor activity of human and dog rectum by diphenylhydantoin.


Lymphangioma of the esophagus--diagnosis by endoscopic biopsy.


Measurement of bile damage to the gastric mucosa. The relation between the electrical potential difference and transmucosal movement of hydrogen and sodium ion.


The effect of body position on lower esophageal sphincter pressure.


A new intestinal tube for studying absorption.


Duplication of the stomach: a cause of anemia.


Gastric stasis and esophagitis following vagectomy without pyloroplasty.


The effect of thyroidectomy on pancreatic exocrine secretion.


Gastroileostomy leading to severe potassium depletion and renal tubular acidosis.


The radiology corner. Retained gastric antrum.


Colonoscopic findings in Pneumatosis cystoides intestinalis.


Sample preparation for chromatography of amino acids.


Double-gradient plate susceptibility testing of an Enterococcus and its L-form.


The effect of thorotrast and cortisone on renal cortical fibrinolytic activity in the rabbit. Previous studies have shown that a single injection of endotoxin inhibits renal cortical fibrinolytic activity in the rabbit. This suggests that the initial injection of endotoxin may prepare for the generalized Shwartzman reaction by depletion of cortical fibrinolytic activity. A fibrin slide technic was used to determine whether Thorotrast(R) and cortisone prepare for the generalized Schwartzman reaction by a similar mechanism. Renal cortical fibrinolytic activity was inhibited following Thorotrast injection, but no inhibition could be detected following cortisone injection. This suggests that Thorotrast, like endotoxin, prepares for the generalized Shwartzman reaction by depletion of cortical fibrinolytic activity. Failure to demonstrate inhibition of lytic activity following cortisone injection may indicate that cortisone prepares for the generalized Shwartzman reaction by another mechanism, or that the fibrin slide technic was unable to detect quantitative changes in lytic activity.


Prognostic factors in cutaneous melanoma of the head and neck. The division of cutaneous malignant melanomas into nodular melanoma, malignant melanoma arising in Hutchinson's melanotic freckle and superficial spreading melanoma has, in many studies, indicated its usefulness for assessing prognosis. The depth of dermal invasion was also found to be an important prognostic factor. The present retrospective study of 119 patients, seen at Memorial Sloan-Kettering Cancer Center from 1947 to 1964, with cutaneous malignant melanoma of the head and neck area examines the above three types of melanoma as well as the depth of dermal invasion. The clinical and pathologic features and course of the disease in these patients were studied by means of a comprehensive statistical analysis. There was significant correlation between the depth of invasion and type of malignant melanoma, with the nodular type being the most deeply penetrating and melanoma arising in Hutchinson's melanotic freckle the most superficial (P < .01). The ten-year actuarial survival rates for clinical stage I patients when grouped according to dermal level of penetration were level II, 86%, vs level V, 44% (P < .01); levels III and IV were 60% and 57%, respectively. Correlations of importance were noted between ulceration and depth of dermal penetration, cellular pigment production and clinical pigmentation, as well as size of the primary lesion and depth of dermal invasion. It is suggested that future large-scale prospective studies include these useful parameters.


Ultrastructural changes of coronary artery endothelium associated with biliary obstruction in the rat. Ultrastructural cellular changes in various target organs have been described in association with experimentally induced biliary obstruction. In the present study, the effect of bile duct ligation on coronary artery endothelium was examined in rats 24 hours after surgery. Electron microscopic examination revealed marked degenerative changes of endothelial cells compared with the lack of such alterations in control animals. Some possible implications of the reported observations for atherogenesis are discussed.


An enzyme electrode for the amperometric determination of glucose.


The determination of molybdenum in sea water by hot graphite atomic absorption spectrometry after concentration on p-aminobenzylcellulose or chitosan.


Determination of nitrate in feedstuffs.

Determination of nitrate in feedstuffs.


The determination of trace amounts of zinc, cadmium, lead and copper in airborne particulate matter by anodic stripping voltammetry.


Chemosterilization of the cabbage root fly under field conditions.


Transmission of rayado fino virus of maize (Zea mays) by Dalbulus maidis.


Studies in vitro and in vivo with powdery mildew fungicides.


Control of potato cyst-nematode, Heterodera rostochiensis, in sandy loam, by Du Pont 1410 (S-methyl 1-(dimethylcarbamoyl)-N-((methylcarbamoyl)oxy) thioformimidate) applied to the soil at planting time.


The fate of carboxin, benomyl and thiabendazole in seed- and soil-treated plants, as shown by in vitro and in vivo bioassays on some epiphytic yeasts.


Hydrophilic lens therapy of superficial sterile corneal ulcers.


Ampicillin, erythromycin and chloramphenicol penetration into rabbit aqueous humor.


Intraocular penetration of  14 C-labeled penicillin after sub-Tenon's or subconjunctival injection.


Meibomian cell adenocarcinoma.

Meibomian cell adenocarcinoma.


Giant conjunctival cyst of the orbit.

Giant conjunctival cyst of the orbit.


Removal of dense secondary pupillary membranes following trauma: report of three cases.


Third nerve palsy: superior oblique transposition surgery.


Effects of inhibitors of protein or RNA synthesis on turnover rate of messenger RNA in rat liver.


The biogenesis of mitochondria 29. Effects of temperature-induced phase changes in membranes on protein synthesis by mitochondria.


Studies of the in vitro phosphorylation of chromatin non-histone proteins in isolated nuclei.


Is the ability to repair damage to DNA related to the proliferative capacity of a cell? The rejoining of X-ray-produced strand breaks.


DNA polymerase and terminal deoxynucleotidyl transferase activity of normal and bacteria-free crown gall tumor tissue cultures of tobacco.


DNA-dependent RNA polymerase from trophozoites and cysts of Acanthamoeba castellanii.


Congenital rubella surveillance: a matter of priorities.


Gastric ischemia: the primary factor in neonatal perforation.


Gallstones in children. Case report, diagnostic clues and recent views on gallstone formation.


Diagnosis of pyloric stenosis by palpation.


Neuropsychological residuals seven years after acute encephalitis. Results of a seven-year follow-up study of 21 children.


Parent education for child education being carried out in a pediatric clinic playroom. A description and preliminary evaluation.


A complication of phototherapy in the newborn: the "bronze baby".


The assessment and treatment of the preschool child with maladaptive behavior in a hospital nursery school. Description of a successful program.


Adolescent sexuality. Counseling, contraception, pregnancy.


Acute glomerulonephritis with minimal urinary abnormalities presenting as hypertension.


Agricultural use of sewage treatment plant sludges, a potential source of mercury contamination.


The microflora of a snow depository in the city of Quebec.


Solubilization of dimethylmercury by halide ions.


The effect of carbon monoxide on the chemistry of photochemical smog systems.


Ozonolysis rates of some atmospheric gases.


Trace metals in oyster shells.

Trace metals in oyster shells.


Cadmium and nickel--common characteristics of lettuce leaf and tobacco cigarette smoke.


Emergency medical services. From ambulance driver to EMT.


Emergency medical services. The social worker's role.


Emergency medical services. Case study. Countywide program in California.


Emergency medical services. Case study. Planning depends on analysis of capabilities.


Emergency medical services. Case study. Radio, training spur improvement.


Emergency medical services. Case study. Survey preludes regional planning.


Emergency medical services. Case study. An EMS system that works.


Trauma nursing in Illinois.

Trauma nursing in Illinois.


Poison prevention: pharmacists wanted.

Poison prevention: pharmacists wanted.


An eye institute in the round.

An eye institute in the round.


The potentials and limitations of emergency medical services.


EMS: a facet of ambulatory care.

EMS: a facet of ambulatory care.


Emergency medical services. Categorization of emergency capabilities.


Emergency medical services. Categorization: a legal view.


The financial realities of EMS.

The financial realities of EMS.


Emergency medical services. Communications improve care.


Ketamine--excellent anesthetic.

Ketamine--excellent anesthetic.


Bovine onchocerciasis in northwest Ohio.


Effect of chemical restraint drugs on the passage of barium sulfate through the stomach and duodenum of dogs.


Response of P-Q intervals to digitalis glycosides in the dog.


Subcutaneous abscess associated with an unusual pseudomonad in a dog.


Current practice problems. Sterilization of endotracheal tubes.


Dirofilariasis: radiologic diagnosis.

Dirofilariasis: radiologic diagnosis.


Diaphragmatic hernia in a horse.

Diaphragmatic hernia in a horse.


The metabolism of testosterone by human male scalp skin.


Urinary pregn-5-ene-3 ,16 ,20 -triol in adrenal dysfunction.


Luteinizing hormone and progesterone in peripheral blood during the ovulatory cycle of the hen Gallus domesticus.


Peripheral plasma levels of oxytocin and vasopressin in the mare during parturition.


Nidation induced in mice during the lactational delay by the presence of strange males.


Thiocyanate ion in serum as an interfering factor in the in-vitro bioassay of thyrotrophin.


Effect of decapitation on the development of insulin secretion in the foetal rabbit.


Initiation of parturition in the rabbit by maternal and foetal administration of cortisol: effect of rate and duration of administration: suppression of delivery by progesterone.


Hormonal specificity in the suppression of sexual receptivity of the female golden hamster.


The persistence of progesterone secretion in pregnant rats after hypophysectomy and hysterectomy: a comparison with pseudopregnant, deciduomata-bearing pseudopregnant, and lactating rats.


The kinetics of oestradiol -17  metabolism in the sheep.


Vasopressin and milk secretion: lack of effect of low doses.


A post-epizootic search for furunculosis in a warm-water fish population.


Seasonal prevalence of Chondrococcus columnaris infection in black bullheads from Clear Lake, Iowa.


Neutralization tests of infectious pancreatic necrosis virus with polyvalent antiserum.


Parelaphostrongylus tenuis (Dougherty) in Maine. I. The parasite in white-tailed deer (Odocoileus virginianus, Zimmerman).


Experimental infection in North American elk with epizootic hemorrhagic disease virus.


Hydrocephalus in a newborn llama.

Hydrocephalus in a newborn llama.


Neurologic disease in wapiti naturally infected with meningeal worms.


Chitinoclastic bacteria associated with shell disease in Penaeus shrimp and the blue crab (Callinectes sapidus).


Parasites of the blackbuck antelope (Antilope cervicapra) in Texas.


Seasonal abundance of Gyrodactylus macrochiri Hoffman and Putz, 1964 on bluegill and largemouth bass.


Ophidascaris filaria (Dujardin 1845) from the African rock python, Python sebae, in the Sudan, with a note on associated gastric lesions.


Reduction of a rectal prolapse in a wild lioness.


Headspace volatiles of marijuana.

Headspace volatiles of marijuana.


Effects of marijuana and tobacco smoke on DNA and chromosomal complement in human lung explants.


Spatial frequency dependent chromatic after-effects.


The role of contours in steropsis.

The role of contours in steropsis.


How much food does man require?

How much food does man require?


Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds.


Rupture of an intracranial aneurysm with ventricular opacification during angiography: case report.


Subfrontal epidural hematomas.

Subfrontal epidural hematomas.


The value of a collaborative neurosurgical and rhinological approach to microsurgery of tumors in the chiasm-sella turcica region.


Conjunctival melanoma in an anophthalmic orbit.


Alignment of eye and slitlamp beam.

Alignment of eye and slitlamp beam.


Optical-ultrasonic procedures for calculating the size of the retinal images in emmetropic and ametropic eyes.


The role of surgery in respiratory emergencies.


Stabilization and transport of severely ill infants.


Complications in the treatment of the respiratory distress syndrome. Bronchopulmonary dysplasia, oxygen toxicity, and the Wilson-Mikity syndrome.


Regionalization for respiratory care.

Regionalization for respiratory care.


Child abuse: the role of the physician and the hospital.


The etiology of child abuse.

The etiology of child abuse.


The diagnosis of the maltreatment syndrome in children.


The law and the abused and neglected child.


Role of the child protective organization.


Role of the courts.

Role of the courts.


A practical approach to the protection of the abused child and rehabilitation of the abusing parent.


Use of a pterygoid muscle sling to provide glossomimic function after total glossectomy.


Some anatomical considerations of subcutaneous mastectomy.


Mandibular lengthening by gradual distraction. Preliminary report.


A dynamic tenodesis of the distal interphalangeal joint, for use after severance of the profundus alone.


Correction of enophthalmos in the anophthalmic orbit.


Use of a retrograde tendon flap in repairing a severed extensor in the pip joint area.


Autotransfusion for blood loss in some major esthetic operations.


Ketamine anesthesia and intranasal or intraoral operations. A potentially dangerous combination.


An appraisal of the treatment of basal cell carcinoma of the skin.


Subcutaneous mastectomy, syntax, and seat belts.


The aftercare of rhytidectomies with the "no-dressing" technique.


More on the "no-dressing" technique.

More on the "no-dressing" technique.


On cleft lip and palate classification.

On cleft lip and palate classification.


A large frontoethmoidal encephalomeningocele. Case report.


Use of dermal flaps for attachment of rhytidoplasty flaps.


Preventing a pulled-down or deformed earlobe in rhytidectomies.


Effect of rubratoxin B on prenatal growth and development in mice.


Adenyl cyclase in neuronal and glial-enriched fractions from rat and rabbit brain.


Factors affecting survival in patients with cancer of the breast. A preliminary study.


Alloxan diabetes and reduced bone density in rat mandible.


Cannabis-induced hypothermia: a dose-effect comparison of crude marihuana extract and synthetic   9 -tetrahydrocannabinol in male and female rats.


Effects of L-asparaginase on lymphocyte's surface leading to decreased binding of alloantibodies.


Effects of PCN and phenobarbital on  3 H-digitoxigenin and  3 H-digoxigenin metabolism by rat liver microsomes.


Reduction of tissue norepinephrine and aortic pressure in spontaneously hypertensive rats by 1,2,3,5-tetrahydroimidazo(2,1-b)quinazoline.


Chronic nicotine treatment in rats. 1. Acquisition and performance of an attention task.


Effect of selenium on methylmercury poisoning.


Effect of   9 -tetrahydrocannabinol on a cholinergic-induced activation of the electroencephalogram in the rabbit.


Chronic nicotine treatment in rats. 2. Electroencephalographic amplitude and variability changes occurring within and between structures.


Effect of dietary cadmium on intracellular distribution of hepatic iron in rats.


Intra-species variation in chlorpromazine metabolism.


Antiserum to diphenylhydantoin: preparation and characterization.


Dose-effect relationships in the action of propanidid on the quantitated EEG of rabbits. Interactions with neuromuscular and cholinergic blockers.


Effect of 5-bromodeoxyuridine (BUdR) on experimental metastasis.


Structure-activity study of adrenocortical inhibiting 2,2-diphenethylamines.


Structure-activity relationships for benzyl alcohols.


Effect of monocrotaline, a pyrrolizidine alkaloid, on regenerating rat liver.


Antagonistic effect of pre-treatment with ATP on phenobarbital poisoning.


The effects of lithium carbonate on serum gastrin in psychiatric patients.


Statistical analysis of reproducibility of radioimmunoassay of digoxin.


Estrogenic activity of norethindrone in the immature female beagle.


The effect of psychotomimetic drugs on interferon production.


Some behavioral and toxicological effects of amyl nitrite.


Aggression and atheroma.

Aggression and atheroma.


Tonsils in or out.

Tonsils in or out.


Tay-Sachs disease.

Tay-Sachs disease.


Dye studies by cannulation of ampulla of Vater through a duodenoscope.


The treatment of varicose veins in pregnancy by empty vein compressive sclerotherapy.


Unusual variants of hyperparathyroidism.


Peptic ulcer in the Rhodesian African.

Peptic ulcer in the Rhodesian African.


Ebstein's anomaly in the neonatal period. A report of three cases.


In vivo and in vitro inhibition of the metabolism of N-alkyl-substituted amphetamines in rat by ferrocenylisopropylamine.


Studies on the metabolism of sympathomimetic amines. The metabolism of ( )-( 14 C) amphetamine in the horse.


Influence of dietary vitamin E and fat on depletion of a cholesterol depot in the liver of chicks.


Alimentary production of gallstones in hamsters. 26. The influence of orally ingested lithocholic, cholic, dehydrocholic and deoxycholic acids on gallstone production compared with the influence of chenodeoxycholic acid.


Deactivation of Rg seed dressing by Arthrobacter sp. 2b.


Effect of lyophilization on morphological and physiological properties of some strains of Azotobacter and Beijerinckia.


Ectopic ureteral implantations.

Ectopic ureteral implantations.


The complications of endoscopic resection.


Evaluation of several methods used in the detection of sickle cell disease.


The effects of leukemia and lymphoma chemotherapy on hematopoietic cells.


Democratization of the instructional program.


The value of the sulfophosphovanillan reaction in lipid screening.


Occupational therapy for lower extremity problems.


Hand function measurement with educable mental retardates.


Occupational therapy and intern collaboration. 2.


Use of trunk supports for severely paralyzed people.


The future of accreditation.

The future of accreditation.


Antibodies to native DNA in systemic lupus erythematosus. A technique of rapid and quantitative determination.


Parathyroid localization using venous catheterization and radioimmunoassay.


Needle bone biopsy in primary hyperparathyroidism.


Atrial injury current in pericarditis.

Atrial injury current in pericarditis.


Q-wave development in acute subendocardial infarction.


Chronic heart block in adults. Clinical and electrophysiological observations.


Experimental heatstroke. A model in dogs.


Pseudogout in the elderly.

Pseudogout in the elderly.


Lack of significant effect of vitamin E on porphyrin metabolism. Report of four patients with various forms of porphyria.


Pathophysiology of metabolic alkalosis.

Pathophysiology of metabolic alkalosis.


Methylguanidine in uremia.

Methylguanidine in uremia.


Resorption of condyloid process of mandible. An unusual manifestation of renal osteodystrophy.


Outpatient dialysis.

Outpatient dialysis.


Disseminated Nocardia brasiliensis infection.


The many facets of secondary hyperparathyroidism.


Histopathology in immune polioencephalomyelitis in C58 mice.


Pentazocine-induced myopathy.

Pentazocine-induced myopathy.


Colonic cancer. Essential information for a pathologic report.


Nonpenetrating injuries of the neck and cerebrovascular accident.


Ultrastructure manifestations of G M1  and G M2  gangliosidosis in fetal tissues.


Pathologic characteristics of hereditary nephritis.


Host-mediated in vivo-in vitro assay for chemical carcinogenesis.


Bone marrow emboli. Their fate in the vasculature of the human lung.


Primary malignant melanoma of central nervous system. Pineal involvement in a patient with nevus of ota and multiple pigmented skin nevi.


Adiposity of small intestinal submucosa associated with malabsorption.


Splenic white pulp in myeloid metaplasia.


Pathology chief residency in university hospitals.


Intrafollicular amyloid in normal parathyroid glands.


Acute myocardial infarction: effect of a rehabilitation program on length of hospitalization and functional status at discharge.


Adhesive forces between muscle fibers and connective tissue in normal and denervated rat skeletal muscle.


The functional life scale.

The functional life scale.


[Motor nerve conduction velocity in normal and diabetic subjects: effect of repeated periods of ischemia].


Objective, quantitative muscle testing in children: a pilot study.


Revascularization of the hand in a patient with complete interruption of the radial and ulnar arteries.


Modification of articulation in dysarthria.


Vertebral artery obstruction by hyperextension of the neck: report of three cases.


Bilious vomiting.

Bilious vomiting.


Myopathic-nephrotic-metabolic syndrome and massive acute arterial occlusions.


Physiologic patterns in surviving and nonsurviving shock patients. Use of sequential cardiorespiratory variables in defining criteria for therapeutic goals and early warning of death.


Peritoneal dialysis for acute renal failure after major abdominal surgery.


Unusual gallstone disease.

Unusual gallstone disease.


Cholecystitis in childhood and adolescence.


Splenic artery aneurysms.

Splenic artery aneurysms.


Polypoid adenomas of Brunner glands.

Polypoid adenomas of Brunner glands.


Toxic dilatation of the colon. A surgical disease.


Brain vascularization by intact omentum.


Adult tropical intussusception in Haiti.


Sinusoidal myocardial perfusion.

Sinusoidal myocardial perfusion.


Gastrin concentration in gastric mucosa. Effect of food and antrectomy.


Crossbow arrow injury of the abdomen.

Crossbow arrow injury of the abdomen.


Surgical treatment of hepatic hemangioma in the newborn.


Prolonged neonatal parathyroid suppression. A sequel to asymptomatic maternal hyperparathyroidism.


Renal angiomyolipoma.

Renal angiomyolipoma.


Vena cava umbrella filter insertion during pulmonary embolectomy.


Surgical treatment of stage I melanoma.

Surgical treatment of stage I melanoma.


Surgical treatment of Stage I melanoma.

Surgical treatment of Stage I melanoma.


Physiological colostomy.

Physiological colostomy.


Nephrocalcinosis in chloride depleted rats. An ultrastructural study.


Mineral fluorapatite. Differences between infrared absorption spectra of powders and faceted surface planes.


Total urinary hydroxyproline excreted in healing experimental rat rickets, studied with  14 C proline.


Inhibition by diphosphonates of bone resorption in mice and comparison with grey-lethal osteopetrosis.


Hydrazine-deproteinated bone mineral. Physical and chemical properties.


The effect of insulin on bone resorption.


Altered venules in the stimulated human thymus as evidence of lymphocyte recirculation.


How frequent are ear lesions and hearing defects among U.S. children? Comments based on a nationwide survey.


Echinococcus cysts of the liver. Observations and reflections based on a medical student's summer spent in Turkey, 1971.


You have to listen.

You have to listen.


Primary renal tubular acidosis recognized and treated at three days of age. A case report illustrating the value of routine postmortem examination.


A field trial of combined measles-mumps-rubella vaccine. Satisfactory immunization with 188 children in Chile.


Clinical clues to emotional disturbances in children. How to suspect and treat disturbances due to nonorganic causes.


Congenital cystic adenomatoid malformation of the left lower lobe with compression of the remaining lung tissue in a newborn.


A complicated case of convulsions.

A complicated case of convulsions.


Direct evaluation of rate constants for an assumed single-step mechanism from chemical relaxation data.


Simulation of the thermal effects of dissolved materials in human sweat.


Pattern recognition for ECG-monitoring: an interactive method for the classification of ventricular complexes.


Investigation of cardiorespiratory abnormalities through computer simulation.


A pattern recognition method applied to EEG analysis.


The on-line analysis of atrial pressures using a digital computer.


Indirect measurement of systolic blood pressure by strain gauge technique at finger, ankle and toe in diabetic patients without symptoms of occlusive arterial disease.


The relation between phenformin therapy and lactic acidosis.


Inhibition of intestinal amino acid transport by blood sugar lowering biguanides.


Insulin labelled by coupling with peroxidase.


Hormonal modification of mouse liver lysosomal protein metabolism by cortisone acetate.


Effects of glucocorticoid and aminophylline on glucose intolerance of adrenalectomized rats.


Sex steroid influence on hepatic gluconeogenesis and glucogen formation.


Requirement of the pituitary gland for gonadal hormone effects on hepatic corticosteroid metabolism in rats and hamsters.


Endocrine effects on leukocytopoiesis in the rat. I. Evidence for growth hormone secretion as the leukocytopoietic stimulus following acute cortisol-induced lymphopenia.


Effect of calcitonin and calcium infusion on plasma phosphate.


Steroidogenesis in ovarian follicles isolated from rabbits before and after mating.


Insulin regulation of spermatozoa metabolism.


Plasma calcium and inorganic phosphate response of laying hens to parathyroid hormone.


A double-isotope method for comparing polyribosome populations: effects of glucocorticoid hormone administration.


Release of FSH after administration of gonadotrophin-releasing hormone or estradiol to the anestrous ewe.


Role of the adrenal in PMS-induced ovulation before puberty: effect of adrenalectomy.


Kinetics of isotopic equilibration of iodine in individual rat thyroid follicles.


Epinephrine precursors: effects on the iodine and intermediary metabolism of isolated calf thyroid cells.


Serum dopamine-beta-hydroxylase during development of immobilization-induced hypertension.


Early effect of testosterone in the incorporation of uridine into RNA of mouse kidney and seminal vesicles.


Effect of estrogen on the phospholipid metabolism of rat bone.


Spectrophotometric studies on the interaction of sarcoplasmic-reticulum fragments with adenosine triphosphate and calcium.


Identification of unconjugated androst-5-ene-diol in human peripheral plasma.


Effect of erythropoietin on the peroxidase and tyrosine-iodinase activity of mouse thyroid and submaxillary gland.


Effect of an additional peptide extension of the N-terminus of collagen from dermatosparactic calves on the cross-linking of the collagen fibres.


Intersociety Committee Methods of Ambient Air Sampling and Analysis.


Addendum to "tentative method for the continuous analysis of total hydrocarbons in the atmosphere (flame ionization method)": flame ionization detector.


Tentative method of analysis for ammonia in the atmosphere (indophenol method).


Tentative method of analysis for carbonate and non-carbonate carbon in atmospheric particulate matter.


General precautions and techniques.

General precautions and techniques.


Liquid chromatography.

Liquid chromatography.


Thin-layer chromatography.

Thin-layer chromatography.


Editorial comments: is silence golden or is there no longer a need for the laboratory section in the APHA?


Fluorescence microscopic distinction between elastin and collagen.


Drug abuse: hassle-free help attracts youth.


Design lines: gradations of intensive care.


The use of menadione as an intermediate hydrogen-carrier for measuring cytoplasmic dehydrogenating enzyme activities.


Polysaccharides associated with chromosomes and their behavior in the cell cycle.


Acid phosphatase in the golgi apparatus of cells forming extracellular matrix of hard tissues.


Buying equipment for new construction.

Buying equipment for new construction.


Pioneer in the HMO concept.

Pioneer in the HMO concept.


Radiology: scheduling system reduces waiting times.


Nursing: parents need TLC, too.

Nursing: parents need TLC, too.


Direct-to-user linen delivery?

Direct-to-user linen delivery?


Ingredient control saves money.

Ingredient control saves money.


The significance of utopian fantasies in small groups.


The experimental group and the psychotherapeutic enterprise.


Communication and aggression in psychoanalytic groups: the group process from the standpoint of interpersonal communication theory.


Problems in black-white encounter groups.


T-group gains in acceptance of self and others.


Individual and group psychotherapy: complementary growth experiences.


What do trainees learn from a group therapy workshop?


Short-term groups of latency-age children in a school setting.


The spontaneous use of poetry in an adolescent girls' group.


Using groups in a crisis-oriented outpatient setting.


Cotherapy: a behavioral and attitudinal survey of third-year psychiatric residents.


An evaluation of recent gas-liquid chromatographic liquid phases for resolution of acetylated plant sterols.


The simultaneous determination of propoxyphene and norpropoxyphene in human biofluids using gas-liquid chromatography.


Determination of sulphur- and chlorine-containing pesticides with an electrolytic conductivity detector.


Thin-layer chromatography of chlorpromazine metabolites. Attempt to identify each of the metabolites appearing in blood, urine and feces of chronically medicated schizophrenics.


Purification of potato virus X, white clover mosaic virus, tobacco mosaic virus and ribosomes by column chromatography.


A simple and inexpensive method for the visual detection of sub-microgram amounts of halogenated substances present in gas chromatographic effluents.


Consultation by newborn hotline.

Consultation by newborn hotline.


Prospective medicine helps close the gap between preventive medicine and the primary physician.


Pituitary apoplexy--a cause of sudden blindness.


Activation of branched and other long-chain fatty acids by rat liver microsomes. Acyl coenzyme A synthetase (EC 6.2.1.3) of rat liver microsomes activates iso- and anteiso-branched long-chain fatty acids containing 12 to 20 carbon atoms. Fatty acid chain length appears to be the major determinant of the maximum rate of acyl CoA biosynthesis of branched, or saturated, or cis monounsaturated long-chain fatty acids. Based on activation studies conducted at 22-45 degrees C, it is concluded that the rate of activation is a function of long-chain fatty acid solubility. The shape of the in vitro activation curve with respect to fatty acid concentration appears to be determined by fatty acid melting point as well as by the presence and position of double bonds. Differently shaped activation curves were observed for cis or trans Delta(6) to Delta(12) central positional isomers of octadecenoic acid and for Delta(3), Delta(4), Delta(13) to Delta(15) terminal isomers of octadecenoic acid. The relationships between fatty acid structure, melting point, solubility, and shape of the activation curve observed during in vitro measurement of acyl CoA formation are discussed.


Identification and quantitation of lipid-bound short-chain diols. Procedures are described for the hydrolysis of neutral lipid fractions containing long-chain esters and alk-1-enyl ethers of short-chain diols, and for the identification and quantitation of the constituent diols as long-chain cyclic acetals using gas-liquid chromatography in combination with mass spectrometry.


Sphingolipid composition of human platelets. Total lipid extracts from washed trypsinized human platelets were fractionated into neutral lipids, glycosphingolipids, and phospholipids by silicic acid chromatography. The concentrations and chemical structures of the neutral and acidic glycosphingolipids were then studied in detail. On the basis of sugar molar ratios, studies of permethylation products, and the action of stereospecific glycosidases on the lipids, identifications were made of four neutral glycosphingolipids. Lactosylceramide was the most abundant type and accounted for 64% of the total neutral glycolipid mixture. The major fatty acids of the lactosylceramide were 20:0, 22:0, 24:0, and 24:1; the major long-chain base was 4-sphingenine. The platelets were surprisingly rich in a ceramide fraction, which represented 1.3% of the total platelet lipids. It had a different fatty acid composition than the neutral glycosphingolipid and ganglioside fractions. Hematoside was also isolated from the total lipid fraction of platelets; the neuraminic acid component was N-acetylneuraminic acid. Treatment of platelets with trypsin, chymotrypsin, or thrombin increased the yield of hematoside as compared with a control, while the level of ceramides was not changed. It was concluded that the platelets are similar to leukocytes, liver, and spleen in that lactosylceramide and hematoside are the principal neutral and acidic glycosphingolipids. The presence of a relatively high proportion of ceramide in platelets may be a unique characteristic of this cellular fraction of blood.


Kinetics of the processes of desorption from fatty acid monolayers. The surface area, A, of contracting fatty acid monolayers was measured as a function of time, t, at constant surface pressure. In the initial temporal phase, ln A was linear with radical t. In a subsequent steady-state phase, ln A was linear with t. The initial desorption coefficient for sodium palmitate, K(i), and the steady-state desorption coefficient, K(s), varied directly with surface pressure and subphase pH, and these desorption coefficients also varied with the composition of the subphase buffer. However, the K(s)/K(i) ratio was independent of these variables. The diffusion coefficient, D(25), for sodium palmitate calculated from desorption coefficient ratios was 4.8 +/- 0.6 x 10(-6) cm(2)/sec. This value was in reasonable agreement with D(25) for sodium palmitate measured by time-lag diffusion, 3.7 +/- 0.6 x 10(-6) cm(2)/sec. D(25) values obtained for a series of fatty acids suggested that higher members of the series diffused as small aggregates averaging two to four molecules in size. Kinetic and diffusion data both supported a model for the desorption process described by Ter Minassian-Saraga.


Glycolipids of peripheral nerve: isolation and characterization of glycolipids from rabbit sciatic nerve. Besides cerebreside and sulfatide four other glycolipids were isolated from rabbit sciatic nerve and analyzed by chemical and chromatographic methods. Three of the glycolipids were shown to be fatty acid esters of cerebroside; the fourth was characterized as diacyl glycerol galactoside and its alkyl ether analog. In the ester linkage mainly unsubstituted acids with chain length C(16) to C(18) were present. Both hydroxy and unsubstituted acids were found in amide linkage. They varied in chain length from C(16) to C(24) and were typical of cerebrosides. The long-chain base fraction contained sphingosine and dihydrosphingosine as the main components.


Bile acid formation in man: metabolism of 7 -hydroxy-4-cholesten-3-one in bile fistula patients. 7alpha-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of (3)H-labeled 7alpha-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7alpha-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis.


Effect of ethionine on carbohydrate and lipid metabolism. In ethionine-treated rats, the ATP content of adipose tissue was not decreased whereas in liver it was drastically reduced to about one-fifth of the control level. Shortly after the injection of ethionine, hepatic glycogen was depleted and the blood glucose concentration fell from 120 to 80 mg/100 ml. This was followed by a two- to threefold elevation of the plasma fatty acid level. Hepatic glucose-6-phosphate was decreased and was not elevated by administration of 2 mmoles of glucose unless ATP was partially restored to normal levels. When hepatic ATP was decreased, the disappearance of [(14)C]glucose from the blood and its incorporation into glycogen and glyceride-glycerol and the incorporation of [3-(14)C]pyruvate into glyceride-glycerol were reduced. 6 hr after ethionine injection the plasma triglyceride level fell but there was no significant change in the liver triglyceride concentration, but by 24 hr it had increased markedly. Lipogenesis in adipose tissue was depressed in vivo, possibly due to decreased glycerol-3-phosphate concentrations. A marked decrease of glycerol-3-phosphate in both liver and adipose tissue was noted. Administration of glucose effectively depressed plasma free fatty acid concentration and elevated the glycerol-3-phosphate levels. Ethionine injection to fasted animals further depressed the blood glucose and elevated the plasma free fatty acid level.


Intramuscular energy sources in dogs during physical work. Three groups of dogs were run under different experimental conditions characterized by varying the work load or the running time. Lipid and glycogen analyses were carried out on biopsy specimens from the biceps femoris muscle before and after exercise. In addition, arterial and venous triglycerides and free fatty acids were determined on plasma samples from one group of dogs that had been previously catheterized. Under the conditions of these experiments, results revealed: (1) plasma triglycerides did not contribute significantly to the energy supply for muscle contraction; (2) plasma free fatty acid efflux into muscle was increased during mild exercise but significantly lowered during heavy exercise; (3) exercise did not affect the phospholipid level or its composition in the muscle; and (4) muscle triglyceride levels may increase, decrease, or remain unchanged, depending upon the work load imposed by the exercise.


Branched-chain and odd-numbered fatty acids and aldehydes in the nervous system of a patient with deranged vitamin B 12 metabolism. A mixture of isomers of methylhexadecanoic acid was isolated from glycerolipids of brain, spinal cord, and sciatic nerve of a patient who died from methylmalonic aciduria, a disease in which vitamin B(12) is not converted to deoxyadenosyl B(12). The isomers were identified by gas-liquid chromatographic-mass spectrometric analyses, and the data indicated that the points of methyl branching are located predominantly on the even-numbered carbon atoms. The concentration of these branched-chain acids among the glycerolipid fatty acids in the patient's nervous system was at least 0.3-0.9%, while the control tissues contained no more than a trace amount, if any, of these acids. In the spinal cord, these branched acids were distributed among all phosphatides and were in highest concentration on the beta position of phosphatidylcholine. On the other hand, most extraneural tissues contained these acids in much lower concentrations; there were only trace amounts in liver, kidney, muscle, and skin, and 0.2, 0.2, and 0.5% in total ester-linked fatty acids in spleen, duodenum, and lung, respectively. A second abnormality was the 6-13-fold increase in 15:0 and 17:0 fatty acids in all of the glycerolipids in the nervous system of the patient. This abnormality was also observed to a somewhat smaller extent in every extraneural tissue examined. The C(17) aldehydes of phosphatidylethanolamine plasmalogens from the spinal cord of the patient were identified by converting them to the corresponding dimethylacetals. 17:0 dimethylacetal accounted for nearly 10% of total dimethylacetals. There were no abnormalities in total lipids, cholesterol, cerebrosides, and sphingomyelins.


Lipogenic activation after nibbling and gorging in mice. Lipogenic activation was studied in mice that had been restricted to a single large meal once a day rather than being allowed to eat at frequent intervals throughout the night. Mice were injected intravenously with [U-(14)C]glucose, and the flux of glucose C to total lipid fatty acids (TLFA) and to all "end products" was estimated from serial plasma glucose specific activities and measurements of incorporation of (14)C into TLFA of hepatic and extrahepatic tissues. Tracer studies were carried out in mice fasted for 1 day and at various times after the mice ate one or two small test meals or a single large test meal. Test meals consisted of a fat-free, 58% glucose diet. The flux of glucose C to TLFA increased by an order of magnitude within an hour after mice nibbled a test meal for several minutes. After ingestion of two small test meals or a single large test meal, the flux of glucose C to TLFA increased from a fasting rate of 0.5 to 35 and 87 micro g of glucose C/min/20 g body wt, respectively. Although trained meal eaters are thought to have abnormally increased lipogenesis, their lipogenic response to a single test meal was the same as that previously reported for untrained nibbling mice. Most of the newly synthesized fatty acids were found in extrahepatic tissues. Ingestion of a first test meal completely prevented the expected hyperglycemic response following ingestion of a second test meal even though the latter contained over 10 times more glucose than that in the total body glucose pool.


Specific role of glucose in rapid lipogenic activation in vivo. Lipogenesis from glucose C was previously found to be rapidly activated as soon as mice nibbled a fat-free, glucose-rich diet. We have studied here whether such rapid activation is a specific effect of dietary glucose. The flux of endogenous glucose C to total lipid fatty acids (TLFA) in mice fasted for 1 day was compared with the minimal average flux of exogenous dietary glucose to TLFA during a 40-min period after the ingestion of various glucose-rich test meals by previously fasted mice. The fasted mice were injected intravenously with [U-(14)C]glucose, and the flux of glucose C to TLFA and to all "end products" was estimated from serial plasma glucose specific activity measurements and (14)C incorporation into TLFA 30 min after (14)C injection. Only 0.6 to 0.8 micro g of glucose C/min/20 g body wt was converted to TLFA, whereas 208 +/- 16 micro g of glucose C/min/20 g body wt was converted to all "end products" in the fasted animals. Previously fasted mice were fed [(14)C]glucose in small test meals as a neat solid, as a 30% aqueous solution, or as a fat-free, 58% glucose diet. During the next 40 min, the average flux of glucose C into TLFA increased at least 50- to 60-fold, regardless of the form in which glucose was fed; however, when glucose was fed as part of a complete fat-free diet, glucose was utilized at a much lower plasma glucose level than in mice fed either pure solid glucose or an aqueous glucose solution. Rapid activation of lipogenesis from glucose requires only glucose as a dietary constituent.


Surface areas of naturally occurring lipid classes and the quantitative microdetermination of lipids. The surface area (A) of a lipid was directly proportional to the amount of lipid in a surface film (A = k micro moles) measured at constant surface pressure, temperature, and subphase composition. A surface area of 2300 cm(2)/ micro mole was obtained for cholesterol isolated from human adrenal and aorta and for cholesterol from hydrolysates of cholesteryl esters isolated from the same tissues. Unsaturated methyl esters that contained from one to four cis double bonds had the same surface area, 39.4 A(2)/molecule. As a consequence, naturally occurring triglyceride mixtures which had similar saturated-unsaturated fatty acid ratios had the same surface area, 6090 cm(2)/ micro mole. Naturally occurring phospholipid mixtures had the same surface area, 4590 cm(2)/ micro mole, and it appeared that the composition of these mixtures was regulated to control the physical properties of the mixtures. Surface area was much more sensitive than colorimetric procedures for the estimation of cholesterol and triglycerides. The surface area/molecule was a criterion of purity and an expanded surface area/molecule was an indication of autoxidation. Thus, surface area measurements were valuable for both the microdetermination and the characterization of lipid classes.


Evaluation of a program designed to produce rural physicians.


An analytical computer-based methodology for screening medical school applicants.


Medical specialty counseling: a survey.

Medical specialty counseling: a survey.


Clinical performance evaluation of junior medical students.


A nonlecture-oriented system of pathology education: rationale, experiences, and analyses.


Relationship between type of pediatric clerkship and performance on pediatric examinations.


Family practice residencies in the community hospital: changing attitudes amid different structures.


A one-year program in basic medical sciences.


Medical ethics courses: some realistic expectations.


Medical education from Alpha to Omega.

Medical education from Alpha to Omega.


A case of eosinophilic granuloma of bone presenting malignant transformation.


Potentiation of cortisone-induced RES suppression in mice by vitamin K 1 .


The fate of intraperitoneally injected colloidal gold particles in mice.


An evaluation of routine electron microscopy in the examination of renal biopsies.


The effect of dialysate magnesium on plasma and erythrocyte magnesium and potassium concentrations during maintenance haemodialysis.


Pyruvate tolerance test in chronic uremic patients.


Ultrastructural changes of the glomeruli of the rat induced by indomethacin.


A simplified method of determining the volume of renal tubular-fluid samples.


Oliguric renal failure complicating lithium carbonate therapy.


Cancer chemotherapy. II. Results of 603 courses of therapy in 400 consecutive patients, followed for 18-52 months.


Host resistance to gastric adenocarcinomatosis in three strains of rats ingesting N-methyl-N'-nitro-N-nitrosoguanidine.


Effectiveness of boronated tetracycline antibiotic derivatives (T 2 B 2 ) as the boron-10 carrier in neutron capture therapy.


Analgesic blocks.

Analgesic blocks.


An operant conditioning method for managing chronic pain.


Chronic pain due to nontraumatic joint disease.


Causalgia and other reflex sympathetic dystrophies.


Myofascial pain syndromes.

Myofascial pain syndromes.


Headache.

Headache.


Neuralgia.

Neuralgia.


Visceral pain.

Visceral pain.


Anesthesia in obstetrics. 2. Regional.

Anesthesia in obstetrics. 2. Regional.


The future of medicolegal matters.

The future of medicolegal matters.


Psychologic aspects of pain.

Psychologic aspects of pain.


Analgesics and other drugs for relief of pain.


Radiobioassay program of the Institutional Total Diet Sampling Network. II. Selected physiological constants of urine.


Radiobioassay program of the Institutional Total Diet Sampling Network. 3. Cesium-137 dose estimates and body burdens of children.


Gross radioactivity in surface waters of the United States October-November 1972.


Water surveillance programs, October 1972.


Radioactivity in airborne particulates and precipitation.


Air surveillance Network, December 1972.


Environmental levels of radioactivity at Atomic Energy Commission installations.


The influences of acute hyper- and hypocalcemia and of calcitonin on exocrine pancreatic function in man.


Influence of erythrocyte deformability on circulation.


Histochemical and biochemical enzyme studies in prostatic carcinomatous tissue before and during treatment with estrogen.


Radiotherapy in treatment of patients with carcinoma of the penis.


Histochemical and biochemical investigation of advanced prostatic carcinoma treated with estramustine phosphate, Estracyt.


Radiation-induced small bowel injury following telecobalt therapy of bladder tumour.


Effects of dextran on postoperative renal function measured by a single injection clearance method.


Fibrin degradation products in serum and urine in patients with renal carcinoma.


Malignant teratoma of testis in a subfertile man treated with HCG and HMG. A case report.


Renal function in burned rats with reference to the effect of intravascular coagulation.


Urine production and metabolism of glucose and lactic acid in the kidney during 36 hours of cooling and perfusion with diluted plasma.


Gross hematuria caused by renal infarction. Report on two cases.


Acute poststreptococcal glomerulonephritis without proteinuria. Case report.


Some morphological and anthropological characters of the orbital region of the East African Bantu skull.


Ultrastructure of Krause end-bulbs in the nasal skin of the cat.


The ultrastructure of quail gall bladder epithelium.


The gallbladder fossa in liver photoscans.


Human bubonic plague from exposure to a naturally infected wild carnivore.


The relationship of intra-uterine radiation to subsequent mortality and development of leukemia in children. A prospective study.


Multiple relative risk functions in case-control studies.


Diphenoxylate hydrochloride intoxication simulating intestinal obstruction.


Chronic disease in former college students. XII. Early precursors of adult-onset diabetes mellitus.


Liver in septic shock.

Liver in septic shock.


The effect of vagal stimulation on the release of secretin and pancreozymin from the small bowel mucosa.


Carcinosarcoma of the esophagus.

Carcinosarcoma of the esophagus.


Esophageal dysfunction in collagen disease.


One swallow does not a diagnosis make.

One swallow does not a diagnosis make.


Abnormal respiration and unusual movements of the diaphragm in patients with neurocirculatory asthenia.


The diaphragm: nobilissimus post cor musculus.


Sideroblastic refractory anemia in a patient with systemic lupus erythematosus.


Inappropriate antidiuretic hormone in Hodgkin's disease.


Effects of D-D, telone or dazomet applied to potato ridges in spring on potato cyst-nematode, Heterodera rostochiensis, in sandy loam and silt loam soils.


Control of potato cyst-nematode, Heterodera rostochiensis, in three soils by small amounts of aldicarb, Du Pont 1410 or Nemacur applied to the soil at planting time.


Cowpea mild mottle, a newly recognized virus infecting cowpeas (Vigna unguiculata) in Ghana.


East African strains of cowpea aphid-borne mosaic virus.


Glasshouse evaluation of some systemic fungicides for control of clubroot of brassicae.


Soil fumigation with methyl bromide: the uptake and distribution of inorganic bromide in tomato plants.


Torsion deformity after femoral fracture in children. A follow-up study.


Jaundice following cardiopulmonary by-pass.


Return to work after femoral shaft fracture.


A new method for the production of experimental ascites in dog. Preliminary report.


Fatal abdominal crisis due to systemic thrombosing vasculitis. Report of a case.


Abdominal injury associated with severe blunt trauma.


Stimulation of clonogenic growth of tumour cells and metastases in the lungs by local x-radiation. Single cell suspensions of two allogeneic tumours (W-256 and Y-P388) injected intravenously produced macrocolonies in the lungs of rats. Colony forming efficiency (CFE, the number of colonies produced by each viable cell injected) was low in 6-week or older rats but was markedly increased by 1000-1500 rad local thoracic irradiation (LTI) given 7-14 days before the tumour cell injection, or by antilymphocytic serum (ALS) but not by sublethal whole body irradiation (WBI). Similarly, LTI increased the incidence of pulmonary metastases produced by a solid tumour growing in the leg muscle. Stimulation of CFE by LTI was a strictly local phenomenon and not due to effects of irradiation on thymus, spleen or other tissues of the rat. LTI failed to increase CFE in immunized rats. It is concluded that (1) LTI stimulates clonogenic growth of tumour cells arrested in the lungs, by causing inflammatory reactions accompanied by regenerative cellular proliferation of lung tissue, which increases the "plating" efficiency of tumour cells, (2) the increase in CFE in lungs is not due to suppression of immunity to tumour growth by LTI.


Hyperthermia (42 degrees C) as an adjuvant to radiotherapy and chemotherapy in the treatment of the allogeneic VX2 carcinoma in the rabbit. As assessed by decrease in tumour volume and inhibition of tumour cell respiration and glycolysis, hyperthermia (intra-tumour temperature 42°C for one hour) potentiated the destructive effect of radiotherapy (1000 rad) on the allogeneic VX2 carcinoma in the hind limb of rabbits, and chemotherapy (methotrexate) produced a similar potentiation of irradiation. The resulting regression of the primary tumour in each case after dual therapy was comparable to that occurring after 3 applications of local hyperthermia, which has been shown to cure 50% of animals with this carcinoma. Combination therapy did not increase the survival time of the rabbits, however, all of which had lung and lymph node metastases at autopsy. The results focus attention on the relationship between a primary tumour and its metastases. The histological picture and the animal survival data suggest that the mechanism of tumour cell death and resorption of necrotic material following treatment may be important in enabling the host to deal with metastatic cells. After combination therapy, many metabolically and mitotically active cancer cells remained in the tumour mass, and the incomplete destruction of the primary tumour may have left the host with a burden of tumour cells too large to be destroyed by the immune system.


The concentration of free and conjugated 3-hydroxyanthranilic acid in the urine of bladder tumour patients before and after therapy, measured with an enzymatic method. The basal concentration of the tryptophan metabolite 3-hydroxyanthranilic acid (3OHA), which has carcinogenic properties, was measured with an enzymatic method of determination which allowed separate measurement of free and conjugated 3OHA. The concentration of free 3OHA in untreated bladder cancer patients was significantly (P <0·001) higher than in a healthy control group, but after local therapy the concentration was significantly lower than before treatment (P <0·01). The concentration of conjugated 3OHA was nearly constant in the three groups. It was concluded that other factors than a genetic determined abnormality might be operating in bladder cancer patients which could lead to an abnormal concentration of 3OHA in their urine.


Pelvic exenteration.

Pelvic exenteration. Pelvic exenteration offers the only possibility for cure in patients who have pelvic recurrence after receiving optimum amounts of irradiation. With improved radiotherapy techniques, the number of patients with isolated central failure is steadily diminishing, but there remains a significant number of patients with recurrent cancer of the cervix after radiation therapy for whom the procedure offers the only chance for life. Each patient must be assessed individually, with the risks of the procedure weighed against the possible benefits. Technical advances continue to reduce the operative mortality and ameliorate the postoperative morbidity associated with pelvic exenteration.


An autopsy study of some routes of dissemination of cancer of the breast. Autopsy records based on 647 primary carcinomata of the breast provided the data to describe a few possible routes of dissemination of cancer of the breast. Calculations were made to test whether the hypothesis of a multistep dissemination of the tumour from the primary site was likely. A multistep dissemination means that the presence of metastases at peripheral sites is influenced by the presence of the tumour in 3 organs, i.e. lungs, liver and bones, very often seeded by the primary cancer.Several interpretations are discussed, with emphasis on those findings which could be explained in terms of a haematic route of dissemination or in terms of an anatomical proximity.


Primary venous obstruction of the upper extremity. Three cases of primary axillary and subclavian venous obstruction presented herein demonstrated the classic findings of swelling, aching or pain, and discoloration following effort in an otherwise healthy person. The clinical diagnosis was confirmed by venography. Residual changes were frequent after treatment that included anticoagulation and thrombectomy.


Gram-negative bacterial endocarditis in narcotic addicts. The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans Administration hospitals increased sharply in 1971 over the average of the four preceding years. Enteric Gram-negative bacilli were the infecting organism in three of the seven cases seen in 1971 but were not found in any cases of endocarditis in the 1967-70 period. Medical treatment of the patients was, in general, unsuccessful in spite of the intensive use of newer antimicrobials active against enteric Gram-negative bacilli. One patient died with fulminant Pseudomonas endocarditis and two others (Pseudomonas and Serratia endocarditis) eventually required operations on the heart before a cure was achieved.


Epidemiology of viral hepatitis in California, 1950-1970. Epidemiologic patterns of type A (infectious) and type B (serum) hepatitis in California from 1950 to 1970 are presented. During this period hepatitis incidence increased greatly among teenagers and young adults but no significant increase occurred in other age groups. Much of this age-specific increase is related to the increasing drug abuse problem during the last decade. Other factors which possibly contribute to the current pattern of hepatitis in California are the overcrowding and inadequate sanitary facilities among a portion of young people between the ages of 15 and 30. Until these factors change or effective vaccines are developed, viral hepatitis will continue to be a significant public health problem.


Hypothyroidism and Addison's disease totally corrected by adrenal replacement therapy.


Lupus nephritis complicated by fatal disseminated coccidioidomycosis.


Gastric phytobezoar and hypoglycemia. Medical management.


Hyaline membrane disease.

Hyaline membrane disease.


Life-threatening dermatoses.

Life-threatening dermatoses. Four life-threatening dermatoses-Stevens-Johnson syndrome, toxic epidermal necrolysis, Kaposi's varicelliform eruption and purpura fulminans-are unique in their abrupt onset and rapid progress to death, but prompt diagnosis and proper therapy can often cure the condition or prevent undesirable sequelae. Since two of the four conditions can follow the use of a variety of drugs and all may be secondary to an infectious agent, any physician may encounter them in practice and should be aware of their seriousness.


The role of the aortic body chemoreceptors in the cardiac and respiratory responses to acute hypoxia in the anesthetized dog.


A cellular calcium pool for contraction of rabbit ileal muscle.


Serum enzyme changes in untrained subjects following a prolonged march.


Rat blood and muscle lactate after prolonged exercise.


The influence of lysine-8-vasopressin, oxytocin, and adrenaline on vascular smooth muscle in the human finger.


Effect of aminotriazole on isopropanol- and acetone-induced potentiation of CCl 4  hepatotoxicity.


Noradrenaline liberation from the dog heart in vivo.


Interaction of amantadine with tyramine and noradrenaline on the cat nictitating membrane.


Magnesium: electroencephalographic and behavioral effects in cats.


The effect of measles on the thymus and other lymphoid tissues.


Comparison of in vitro effects of anti-skin serum with anti lymphocyte serum.


The Food and Drug Administration's over-the-counter drug review: why review OTC drugs?


The Roche Institute of Molecular Biology.


Workshop on osteoarthritis. Introduction.


Growth hormone and articular cartilage.

Growth hormone and articular cartilage.


D-galactosamine and acute liver cell injury.


Revised surgical dressing program.

Revised surgical dressing program.


Project management--new characters, new results.


Pastoral education--one approach.

Pastoral education--one approach.


Educating & training management in collective bargaining & labor relations.


Demographic findings and health care: a model for student nurses.


The chaplain: priest, prophet, and king.


Free visitor telephone.

Free visitor telephone.


The emergency cart.

The emergency cart.


Five Connecticut hospitals form laundry cooperative.


Annual administrative reviews. 4. Community.


Annual administrative reviews. 1. Organization.


Hospitals, physicians, and income taxes.


Annual administrative reviews. 2. Environment.


Synopsis of mammo-renal syndromes. II.

Synopsis of mammo-renal syndromes. II.


Age determination by immunological techniques of the last common ancestor of man and chimpanzee.


Metaphase chromosomes from neonatal urine.


Spontaneous chromosomal instability.

Spontaneous chromosomal instability.


Hypnosis in a case of long-standing psoriasis in a person with character problems.


Terpsichoretrancetherapy: a new hypnopsychotherapeutic method.


Hypnotic susceptibility, amnesia, and IQ in chronic schizophrenia.


Comparison of the Harvard Group Scale of Hypnotic Susceptibility, Form A and the Group Alert Trance Scale in a university population.


The effect of hypnotic ablation of the background on the magnitude of the Ponzo perspective illusion.


Hypnotic age regression and the Ponzo and Poggendorff illusions.


Peripheral skin temperature responses to hot and cold suggestions.


Analysis of the heterogeneity of "faking" and "simulating" performance in the hypnotic setting.


Hypnosis, attribution, and demand characteristics.


A trial of prophylactic replacement therapy in haemophilia and Christmas disease. A trial of prophylactic replacement therapy in low dosage once a week is described in two patients with classical haemophilia and one patient with Christmas disease, using concentrates of factor VIII and factor IX respectively. The clinical effectiveness and complications of the therapy are assessed and discussed. It was concluded that the patient suffering from Christmas disease showed both objective and subjective improvement while on prophylaxis and merited further study. Neither of the patients with haemophilia showed objective evidence of improvement, but both stated that they felt fitter and more able to lead a normal life while on the trial.


Effects of changes in temperature (local and central) on plasma fibrinolytic activity. The effect of local and whole-body heating and cooling on plasma fibrinolytic activity has been investigated in 59 subjects. An increase in whole-body temperature and both local cooling and heating increased the fibrinolytic activity. The results demonstrate that the application of local heat or cold will produce a local increase in fibrinolytic activity which is independent of general factors such as emotion and stress.


Reference method for the erythrocyte sedimentation rate (ESR) test on human blood.


The reproducibility and use of the tritiated folic acid urinary excretion test as a measure of folate absorption in clinical practice: effect of methotrexate on absorption of folic acid. Investigations into the standardization and reproducibility of the urinary excretion method for determining the absorption of tritiated folic acid were carried out. By proper timing of tissue-loading doses of folic acid a clear difference between the percentage excretion ranges of normal and coeliac subjects was obtained. In addition conditions were found whereby the procedure could be repeated on an individual up to four times with reproducible results. Methotrexate in pharmacological amounts was found to have no inhibitory effect on the human intestinal absorption of a small oral dose (300 mug) of folic acid as determined by this method. This indicates that reduction of folic acid is not necessary for its absorption in man.


Lysozymuria and acute disorders of renal function. On the assumption that increased urinary lysozyme concentration (;lysozymuria') indicates tubular proteinuria and therefore impaired tubular function, urinary lysozyme has been estimated in acute disorders where transient disturbances of renal function might be expected, in cases diagnosed clinically as extrarenal uraemia, and in a few examples of acute renal disease. Reversible lysozymuria occurred with hypokalaemia, postoperative ;collapse', electrolyte depletion, severe extrarenal infection, acute pyelonephritis, the nephrotic syndrome, after a few apparently uncomplicated surgical operations, and very transiently after ventricular fibrillation abolished by DC shock. There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis. Although lysozymuria may occasionally be useful in the clinical diagnosis of acutely disordered renal function, the results suggest that its value is limited; on the other hand, they have provided information on renal pathophysiology in acute disease.


A simple, inexpensive gel filtration technique for use in diagnostic serology.


Wet ashing using a closed system.

Wet ashing using a closed system.


Hazards of the first nine months: an epidemiologist's nightmare.


Bogus branched-chain aminoaciduria.

Bogus branched-chain aminoaciduria.


Rubella contact in pregnancy.

Rubella contact in pregnancy.


Reproductive medicine.

Reproductive medicine.


Hodgkin's, infections and neutrophils. Infectious complications in Hodgkin's disease.


Carpal tunnel syndrome. A review of cases treated surgically.


Diagnosis of streptococcal pharyngitis.

Diagnosis of streptococcal pharyngitis.


KUMC trauma conference. Point-blank shotgun wound of the abdomen.


Surgical treatment of complications of myocardial infarction.


Surgical considerations in the management of hiatal hernia and esophagitis.


Congress' continuing view of health care.


The Yale Health Plan: a 'university family' HMO.


Biomedical research opportunities in the HMO.


Behavioral research opportunities.

Behavioral research opportunities.


Educational program research and development.


Ideals and realities of academic medical center involvement with HMOs.


Medical student roles in prepaid group practice.


Teaching ambulatory care in an HMO.

Teaching ambulatory care in an HMO.


Training for primary care.

Training for primary care.


Faculty tradition and the HMO.

Faculty tradition and the HMO.


Problems and issues in the academic medical center's relationship to HMO projects.


Issues of governance of university-sponsored HMOs.


Academic medical center-HMO relationship: sponsorship or affiliation?


Alternative patterns in relationships between an academic medical center and an HMO.


Should an HMO be an integral part of the university medical center?


HMOs: hopes and aspirations.

HMOs: hopes and aspirations.


Federal support for HMOs.

Federal support for HMOs.


Evaluation of serum thyroxine by radioimmunoassay.


Scintigraphic study of pulmonary blood flow distribution in cystic fibrosis.


99m Tc-pertechnetate transport in man: absorption after subcutaneous and oral administration; secretion into saliva and gastric juice.


Focal iatrogenic increased radiocolloid uptake on liver scan.


A new radiopharmaceutical for combined lung-liver scan--preliminary experiment in animals.


Radiopotassium-38 for in vivo studies of dynamic processes.


Radionuclide demonstration of spinal dural leaks.


Simple way to widen the spectrometer window in the Ohio-Nuclear scanner for  67 Ga scanning.


Reduction in scan time with minification.


Quality control of radiopharmaceutical kits.


Management of rectal trauma.

Management of rectal trauma.


Disseminated intravascular coagulation in burned patients.


The biomechanical basis of chest impact protection. II. Effects of cardiovascular pressurization.


Exteriorization of repaired missile wounds of the colon.


Manifestations and management of acute arterial injuries.


Effect of hypovolemia on absorption of injected fat.


The challenge of the Skoraya.

The challenge of the Skoraya.


Bullet embolism to the heart.

Bullet embolism to the heart.


Effect of selected  -diketones on lithium fluxes of bovine red blood cells.


Xanthine oxidase from bovine thyroid glands.


Free tryptophan in serum controls brain tryptophan level and serotonin synthesis.


Coma in the diabetic.

Coma in the diabetic.


Cell membranes.

Cell membranes.


Smoking and pregnancy.

Smoking and pregnancy.


Smoking in pregnancy.

Smoking in pregnancy.


The short-term effects of aspirin on the rat kidney: further observations.


The surgery of hyperparathyroidism.

The surgery of hyperparathyroidism.


Balantidium coli in a cervico--vaginal smear.


Massive epistaxis from a ruptured traumatic internal carotid artery aneurysm.


Hyperglycaemic non-ketotic coma.

Hyperglycaemic non-ketotic coma.


Systematics of leptospirae strains isolated in the Sepik District, Papua New Guinea.


Drug addiction or drug dependence?

Drug addiction or drug dependence?


Exocrine pancreatic disease in childhood.


Termination of pregnancy, Sydney, 1972.

Termination of pregnancy, Sydney, 1972.


Aboriginal infant health and mortality rates.


Medical responsibility concerning patients who drive.


Medical sophrology.

Medical sophrology.


Wheat germ agglutinin blocks mammalian fertilization.


Induced nucleophilic substitution in benzo(a)pyrene.


Cholinesterase inhibitors: structure of eserine.


Chronoperiodicity in the response to the intra-amniotic injection of prostaglandin F 2   in the human.


Milk proteins.

Milk proteins.


Relation between glucose absorption rate and serum globulin concentration in man.


Retention of pacemaker activity in mammalian myocardial cells recovered from liquid nitrogen.


Cigarette smoke: effect of aqueous and nonaqueous fractions on mitochondrial function.


Changes in critical flicker frequency during and after fourteen days of monocular deprivation.


Drug therapy for cardiac arrhythmias.

Drug therapy for cardiac arrhythmias.


Differential diagnosis of artial tachyarrhythmias.


Classification of atrioventricular block.


Mechanism of intermittent bundle-branch block and paroxysmal atrioventricular block.


The Wolff-Parkinson-White syndrome.

The Wolff-Parkinson-White syndrome.


A comparison of scintiscans and arteriograms for identifying metastatic intrahepatic tumors.


Delayed cutaneous hypersensitivity reactions to membrane extracts of carcinomatous cells of the cervix uteri.


Early results of the treatment of duodenal ulcer by ultraselective vagotomy without drainage.


Fibrinolysis and circulating malignant cells.


Fixed defects of the gallbladder wall and adenomyomatosis.


Experimental and clinical studies of gastroplasty in the management of acquired short esophagus.


The surgical care of severe infections in obstetric and gynecologic patients.


Noninvasive quantitation of venous reflux in the postphlebitic syndrome.


Early debridement in pit viper bite.

Early debridement in pit viper bite.


Management of the contralateral breast after mastectomy for unilateral carcinoma.


The effect of intraluminally administered glucose in reducing fluid and electrolyte loss from the ischemic intestine.


Why the declining census in university hospitals?


Control of hemorrhage from the internal jugular vein by a balloon catheter.


A simple recording system for the diagnosis of Hirschsprung's disease and idiopathic megacolon.


Innovation in the operative management of the thoracoabdominal aortic aneurysm.


Transfer between the cerebral hemisphere in human learning.


Leukopenia in alcoholics.

Leukopenia in alcoholics.


The natural history of aortic regurgitation. A clinical and hemodynamic study.


Alimentary hypoglycemia associated with the Zollinger-Ellison syndrome.


Renal vein thrombosis and the nephrotic syndrome. Report of two cases with successful treatment of one.


Primary oxalosis.

Primary oxalosis.


Hyperviscosity syndrome in multiple myeloma. A reversible, concentration-dependent aggregation of the myeloma protein.


A hospital riot: its determinants and implications for treatment.


Psychiatry and group medical practice: the diagnostic process, referral patterns, and utilization of services.


A year's experience in student mental health at West Point.


Psychiatric factors in security screening.


Psychiatry residents as college teachers: an evaluation of a training for teaching program.


"Credentials consciousness": stimulus for continuing education and peer review in psychiatry.


A school for medicine men.

A school for medicine men.


Psychiatry in South Korea.

Psychiatry in South Korea.


The psychotherapy of schizophrenia: does it work?


Controversies about the psychotherapy of schizophrenia.


The treatment of schizophrenia: illusion or elusion?


Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings.


Dreams as a prognostic factor in alcoholism.


Depersonalization, dysphoria, and thought disturbance.


Marijuana and amphetamine: the question of interaction.


The relationship between background and extent of heroin use.


The psychiatric treatment of the geriatric patient.


Psychiatrists in the ghetto.

Psychiatrists in the ghetto.


Concomitant imipramine and methylphenidate administration: a case report.


Residential treatment: should it be concomitant with family therapy?


Statements about Viet Nam: APA's role.

Statements about Viet Nam: APA's role.


Succinylcholine in EST.

Succinylcholine in EST.


Sexual freedom in adolescents: a reaction formation?


Danger of depot phenothiazine treatment in acute psychosis.


American Psychiatric Association position statement on the confidentiality of medical research records.


American Psychiatric Association position statement on college mental health.


American Psychiatric Association. Joint statement on antisubstitution laws and regulations.


The pediatric nurse associate: who is she, what does she do.


A pediatric nurse associate program for Arizona.


Dissecting aortic aneurysm-a case report.


Regional Medical Program.

Regional Medical Program.


Orientation of pigeons after transatlantic displacement.


The actual biochemical block in the arg-2 mutant of Chlamydomonas reinhardi.


Age-dependent allozymic variation in a natural population of lizards.


Genetics of aryl hydrocarbon hydroxylase induction in mice: additive inheritance in crosses between C3H-HeJ and DBA-2J.


G6PD Toronto.

G6PD Toronto.


Aspects of the biochemistry and ultrastructure of a cytoplasmically inherited plastid defect (Dpl) of tobacco.


Genetic polymorphism of lactate dehydrogenase isoenzymes in the carp (Cyprinus carpio) apparently due to a "null allele".


Abnormal stomatal behavior and root resistance, and hormonal imbalance in three wilty mutants of tomato.


Evolution of the immunoglobulin antigens in the ruminantia.


Regulatory interactions involving two hemoglobin loci of Chironomus.


Biochemical polymorphism in the rat, Rattus norvegicus: genetic study of four markers.


Isolation of glucagon-like immunoreactivity of gut by affinity chromatography on anti-glucagon antibodies coupled to sepharose  4 B.


Conformation of the LL and LD hairpin bends with internal hydrogen bonds in proteins and peptides.


Electrophoretic heterogeneity of human  -mannosidase.


The binding site of retinaldehyde in cattle rhodopsin.


Circular dichroism of modified tryptophan residues.  -3-oxindolyl-L-alanine.


Synthesis of (Pro-Hyp-Gly) n  of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline.


Kinetics of the reaction of the masked sulphydryl groups of haemoglobins A, E and New York with p-chloromercuribenzoate.


Sequence of amino acids in the major and minor   chains of the diffuse hemoglobin from BALB-c mice.


Kinetic studies on the aggregation of kappa-casein by Mucor pusillus protease.


A study on the F-actin-tropomyosin-troponin complex. I. Gel-filament transformation.


Theory of the non-planar peptide unit.

Theory of the non-planar peptide unit.


A semiquantitative theory of synaptic vesicle movements. Under the assumption that vesicles are the anatomic correlate of quantal release, the forces governing the movement of synaptic vesicles inside neurons are analyzed. Semiquantitative calculations are presented to show that a diffuse layer field penetrates a few Debye lengths into the axoplasm. This field binds tightly a monolayer of water to the membrane forming the potential barrier for miniature end-plate potential (mepp) release. The action potential destroys the monolayer and pulls the vesicle to the membrane. The vesicles are brought to the synaptic zone and held there by a Na(+) leak in the synaptic membrane. A stochastic theory of synaptic vesicle release is presented to explain experimental results. The rate of vesicle release is fractionated into a rate of membrane contacts by a vesicle and a rate of vesicle discharge per contact.


The double fixed charge membrane. Low frequency dielectric dispersion. An analysis is made of the AC characteristics of a membrane consisting of two fixed charge regions of opposite sign, in contact. It is shown that the equivalent parallel capacitance and conductance of such a membrane undergo a strong dispersion at low frequencies. The dielectric dispersion is a result of polarization effects in the diffusion of coions in each of the two fixed charge lattices. This, at low frequencies, gives rise to a very large diffusion capacitance. The form of the dispersion characteristics is very similar to those observed for synthetic-fused anion-cation membranes and various cellular membranes.


The double fixed charge membrane. Solution-membrane ion partition effects and membrane potentials. An analysis is made of the effect of solution-membrane partition of ions on the electrostatic potential and ion concentration profiles in fixed charge membranes. It is shown that the inclusion of partition effects gives rise to large solution-membrane "Donnan" potentials even when the concentration of fixed charges is of the same order as the concentration of the external solution. This effect renders the system and the simplified analysis of the double fixed charge membrane (FCM) previously given more applicable to biological membranes. An analysis is also given of the voltage dependence of the fluxes of individual ion species in the double FCM when it separates different ionic solutions and an expression is deduced for the membrane resting potential. Although the latter is similar in form to the Goldman-Hodgkin-Katz (GHK) equation the corresponding value of the permeability ratio P(C1)/P(K) is under certain specified conditions both concentration and potential dependent.


Physical properties of Onsager's dipole chain model for ionic transport across membranes. I. Steady-state fluxes and instabilities. The steady-state fluxes in Onsager's model for ionic transport along a dipole chain are derived by application of Hill's diagrammatic technique for unimolecular systems. It is shown that under specific conditions the chain exhibits thermodynamic instabilities which prove to be a possible explanation for the phenomenon of electrical excitation in biological membranes.


Repair kinetics of radiation-induced mitotic delay. The recovery from radiation-induced mitotic delay in asynchronous sarcoma-180 (S-180) ascites tumor cells has been analyzed in a manner analogous to the repair of sublethal damage. 200-R increments were separated by various fraction intervals (not exceeding the time necessary for mitosis to return to control levels) for total exposures up to 1600 R. The accumulated mitotic delay after the last exposure increment, in percent of an equivalent single exposure, decreased exponentially with overall treatment time in a bimodal fashion. An initial repair process displayed a half time of 2.3 h of overall elapsed time and was followed by a slower process with a half time of 15.1 h. Such a bimodal recovery provides an explanation of why fractionation intervals long with respect to the amitotic period resulting from a single 200 R exposure enhance mitotic delay over that of equivalent single exposures, while shorter fractionation intervals diminish it. It also predicts that mitotic delay vs. dose curves should bend toward the abscissa as the exposure time is increased with large single exposures and large fractionated exposures given over short fraction intervals.


Kinetics of diffusion and convection in 3.2-A pores. Exact solution by computer simulation. The kinetics of transport in pores the size postulated for cell membranes has been investigated by direct computer simulation (molecular dynamics). The simulated pore is 11 A long and 3.2 A in radius, and the water molecules are modeled by hard, smooth spheres, 1 A in radius. The balls are given an initial set of positions and velocities (with an average temperature of 313 degrees K) and the computer then calculates their exact paths through the pore. Two different conditions were used at the ends of the pore. In one, the ends are closed and the balls are completely isolated. In the other, the ball density in each end region is fixed so that a pressure difference can be established and a net convective flow produced. The following values were directly measured in the simulated experiments: net and diffusive (oneway) flux; pressure, temperature, and diffusion coefficients in the pore; area available for diffusion; probability distribution of ball positions in the pore; and the interaction between diffusion and convection. The density, viscosity, and diffusion coefficients in the bulk fluid were determined from the theory of hard sphere dense gases. From these values, the "equivalent" pore radius (determined by the same procedure that is used for cell membranes) was computed and compared with the physical pore radius of the simulated pore.


A nuclear magnetic resonance study of hydrated systems using the frequency dependence of the relaxation processes. A practical method is described for determining some characteristics of the spectrum of proton mobilities in a hydrated system from the frequency dependence of the nuclear magnetic resonance (NMR) relaxation processes. The technique is applied to water in association with agarose and gelatin. The results for agarose are consistent with the hypothesis that a fraction of the protons is distributed over states of reduced mobility and exchanges rapidly with the remaining fraction which is attributed to water in the normal state. No variation in the characteristics of the modified fraction could be detected for water concentrations in the range 1.2-50 g H(2)O/g agarose. Within the modified fraction, higher mobilities are more common than low mobilities; at 1.2 g H(2)O/g agarose, not more than 10% of the proton population has mobilities more than 100 times smaller than normal. The modified proton fraction is tentatively identified with agarose hydroxyl protons and possibly water molecules bound to the polymer. Proton states with mobilities intermediate between water and ice have also been detected in hydrated gelatin. As in agarose, higher mobilities are the most common. In contrast to agarose, the characteristics of the modified proton states are markedly dependent on water concentration. They are tentatively attributed to gelatin protons coupled for spinlattice relaxation with those of the bulk phase by exchange and spin diffusion.


Impaired atrial receptor responses in dogs with heart failure due to tricuspid insufficiency and pulmonary artery stenosis.


Reflex diuresis during tachycardia in the dog. Evaluation of the role of atrial and sinoaortic receptors.


Arterial baroreceptor fibers from the aortic region of the dog in the cervical vagus nerve.


Action of manganese ions and tetrodotoxin on atrioventricular nodal transmembrane potentials in isolated rabbit hearts.


Biochemical alterations caused by hypoxia in the isolated rabbit aorta. Correlation with changes in arterial contractility.


Influence of norepinephrine and digitalis on myocardial oxygen consumption in the newborn lamb.


Reversal of ouabain-induced electrophysiological effects by potassium canrenoate in canine Purkinje fibers.


Functional transverse interconnections within the His bundle and the bundle branches.


Influence of flow and pressure on wave propagation in the canine aorta.


Sympathetic nervous system and deoxycorticosterone-saline hypertension.


Alteration in the blood sugar level following exogenously administered catechol hormones in the murrel, Ophicephalus punctatus.


The effects of castration and repositol testosterone treatment on exercise-induced glycogen and free fatty acid mobilization.


Influence of high level of endogenous Glucocorticoids on the histology of fetal rat thyroid.


Possible influence of testicular hormone on pyridoxal phosphate formation in vivo by the kidney tissue after administration of flavin mono nucleotide.