Ribosomes, polyribosomes, and deoxyribonucleic acid from thermophilic mesophilic, and psychrophilic clostridia. Analysis of deoxyribonucleic acid (DNA) from four species of Clostridium, including two thermophiles, a mesophile, and a psychrophile, revealed no obvious relationship between growth temperature and DNA base composition. The melting temperatures (T(m)) of the DNA from the four species varied no more among the thermophilic, mesophilic, and psychrophilic species than among many related mesophilic species. Characterization of ribosomes from the clostridia by means of optical rotatory dispersion yielded similar spectra in common with other unrelated organisms. Only small differences were noted in the base composition of ribosomal ribonucleic acid (RNA) and in the amino acid composition of ribosomal proteins, including half-cystine content, as determined by cysteic acid analysis, and accessible sulfhydryl groups, as determined by titration with dithiobis (2-nitrobenzoic acid). Except for the two thermophiles, the ribosomal protein electrophoretic patterns were dissimilar. No unusual thermal stability was manifested in the T(m) values of thermophile ribosomal RNA. However, thermophile ribosome T(m) values (69 C) were higher than were mesophile and psychrophile T(m) values (64 C). Ribosomes from the four clostridial species were also examined in regard to the effect of heat on their functional integrity, measured by their activity in poly U-directed (14)C-phenylaline incorporation, and their gross physical integrity, measured by sucrose gradient analysis. The T(d, 5) values (temperature which produces 50% inactivation after 5 min) was found to be 70 and 72 C for the two thermophiles C. tartarivorum and C. thermosaccharolyticum, respectively; 57 C for a mesophile, C. pasteurianum; and 53 C for a psychrophile, Clostridium sp. strain 69. At 55 C, little effect was seen on the thermophile ribosomes, but the mesophile ribosomes lost 90% of their activity in 1 hr, and psychrophile ribosomes lost 100% of their activity within 10 min. According to sucrose gradient profiles, heating at 55 C results in dissociation of mesophile ribosomes and aggregation of psychrophile ribosomes. Thermophile S-100 fractions were also more thermostable than were mesophile or psychrophile S-100 fractions. The T(d, 5) values were 69 C for C. tartarivorum and C. thermosaccharolyticum S-100 and 41 C for C. pasteurianum and Clostridium sp. strain 69 S-100. The effect of heat on the endogenous incorporation of (14)C-valine by polysomes was also examined. In the case of thermophile polysomes, the extent of incorporation at 55 and 37 C was about equal. In the case of mesophile and psychrophile polysomes, the extent at 55 C was 44 and 39%, respectively, of the value at 37 C. The initial rates of incorporation in all four cases were greater at 55 C than at 37 C.


Dietary regulation of liver glucose-6-phosphate dehydrogenase in the rat: starvation and dietary carbohydrate induction.


Tissue sulfhydryl groups in selenium-deficient rats and lambs.


Ultrastructure of free-living and nitrogen-fixing forms of Rhizobium meliloti as revealed by freeze-etching. Freeze-etching of Rhizobium meliloti provided considerable insight into the ultrastructure of this bacterium and into the changes accompanying the transformation from the free-living rod forms to the nitrogen-fixing bacteroid forms. In the small rods, one cleavage plane was revealed at the level of the cell wall and a second at the level of the plasma membrane. Very little structure was evident at the cell wall level, but distinctly different convex and concave fracture faces were exposed at the cell membrane cleavage plane. During the transformation into the bacteroidal state the wall decreased in thickness, became less rigid, and developed a particulate surface. In addition, changes in particle density were observed in the plasma membrane. The fine structure of the plant membranes, the infection threads, and the arrangement of the bacteroids within the plant cells also were revealed.


Appetite regulation in the rat under various physiological conditions: the role of dietary protein and calories.


Fat versus sucrose as the nonprotein calorie portion of the diet of rats.


Effect of methionine on specific folate coenzyme pools in vitamin B 12  deficient and supplemented rats.


Hypervitaminosis E in the chick.

Hypervitaminosis E in the chick.


Effect of dietary excesses of lysine and arginine on the degradation of lysine by chicks.


Influence of dietary protein level on plasma cholesterol turnover and fecal steroid excretion in the chick.


Effect of dietary lactose on intestinal lactase activity in young rats.


Detailed body composition analysis on female rats subjected to a program of swimming.


Nitrite-induced methemoglobinemia in guinea pigs: influence of diets containing beets with varying amounts of nitrate, and the effect of ascorbic acid, and methionine.


Growth, serum chemical values and carcass composition of Pitman-Moore miniature pigs during the first eight weeks of life.


Changes in tissue magnesium, calcium and phosphorus levels in magnesium-deficient rats in relation to thiamin excess or deficiency.


Biochemical and histochemical studies of the selenium-deficient pancreas in chicks.


Gastrointestinal growth in the fetus and suckling rat pups: effects of maternal dietary protein.


Cortical-evoked responses in pyridoxine-deficient rats.


Effect of adipose tissue site, animal weight, and long-term fasting on lipogenesis in the bovine.


The defendant's dilemma: effects of jurors' attitudes and authoritarianism on judicial decisions.


Authoritarian behavior in a conflict situation.


Smoking, physiological arousal, and emotional response.


Context effects in observed violence.

Context effects in observed violence.


Traditional sex-determined role standards and sex stereotypes.


When do opposites attract? When they are opposite in sex and sex-role attitudes.


Internal versus external control of reinforcement and reaction to frustration.


Individual differences multidemensional scaling of adjectives denoting feelings.


Stimulus inconsistency and response dispositions in forming judgments of other persons.


Dissonance, self-perception, and honesty in children.


Interactive effects of eye contact and verbal content on interpersonal attraction in dyads.


Characterization of batrachotoxin-induced depolarization of the squid giant axons.


Inhibition by cadmium ions of the electrical activity of sinoatrial nodal pacemaker fibers and their response to norepinephrine.


Increase in sodium permeability of squid axon membranes by  -dihydrograyanotoxin II.


Similarities and differences between mescaline, lysergic acid diethylamide-25 (LSD) and d-amphetamine on various components of fixed interval responding in the rat.


The effects of chlorpromazine, pentobarbital, chlordiazepoxide and d-amphetamine on rates of licking in the rat.


Biliary excretion of morphine-3-glucuronide and morphine-3-ethereal sulfate by different pathways in the rat.


Identification by gas chromatography-mass spectroscopy of dihydrodigoxin--a metabolite of digoxin in man.


The effect of cyproterone acetate pretreatment on the in vitro metabolism of aniline, hexobarbital and  3 H-digitoxigenin.


Methimazole: absorption, metabolism and excretion in the albino rat.


Transport of salicylic acid by the choroid plexus in vitro.


Micropuncture study of the effect of triflocin on tubular reabsorption in rats.


Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyflurane in rats.


Placental transfer and tissue distribution of mescaline- 14 C in the mouse.


Tachyphylaxis of guinea-pig ileum to histamine and furtrethonium.


The reduction of lidocaine clearance by dl-propranolol: an example of hemodynamic drug interaction.


Repeated acquisition as a behavioral base line for studying drug effects.


So-called "nervous habits".

So-called "nervous habits".


Creativity in rural, urban, and Indian children.


Brainstorming in large groups as a facilitator of children's creative responses.


Drug usage, personality, attitudinal, and behavioral correlates of driving behavior.


Congruence of adolescents' self-concepts and parents' perceptions of adolescents' self-concepts.


A study of the self-esteem and alienation of male homosexuals.


Creativity: performance, profiles, and perceptions.


The dyslexic child--two years later.

The dyslexic child--two years later.


Age, sex, and title of therapist as determinants of patients' preferences.


A child-adult research form of the Pittsburgh Scales of Social Extraversion-Introversion and Emotionality.


Behavioral variability among retardates, children, and college students.


Impaired sex-role identification in schizophrenia expressed in the comprehension of humor stimuli.


Relations among sensation seeking and simulated and behavioral personal space.


Reactions to aggression-related stimuli following reinforcement of aggression.


Reach to recovery: a postmastectomy rehabilitation program.


Enterocolitis in an infant.

Enterocolitis in an infant.


The treatment of status canvulsivus and epilepticus in children.


Expanded role of area advisory groups.

Expanded role of area advisory groups.


Geriatric services in Tennessee.

Geriatric services in Tennessee.


EKG of the month: Wolff-Parkinson-White syndrome.


Total hip replacement in a community hospital.


Silicone granulomatous disease of the breast simulating cancer.


Perinatal tips.

Perinatal tips.


Neonatal immunology: a review of host response to infection.


Non-allergic adverse reactions to aqueous procaine penicillin G.


The amniotic band syndrome.

The amniotic band syndrome.


Maternal, fetal and amniotic fluid levels of glucose, insulin and growth hormone.


Human amniotic fluid isoamylases. Functional development of fetal pancreas and salivary glands.


Estriol and creatinine in pregnancy urine.


Induction of labor by breast stimulation.


The effects of pressure on fetal heart rate.


Quantification of fetal heart beat-to-beat interval differences.


Cervical cord injuries secondary to hyperextension of the head in breech presentations.


Diagnostic ultrasound in obstetrics and gynecology: experience on a large clinical service.


Effects of diazepam on uteroplacental and fetal hemodynamics and metabolism.


Puerperal tubal ligation morbidity, histology and bacteriology. To assess the relationship of morbidity to the time interval between delivery and puerperal tubal ligation, 76 women were studied after receiving a tubal ligation.  The women were divided into 4 subgroups relating to the time interval of the tubal ligation after delivery from 12-108 hours.  Morbidity was defined as (1) puerperal morbidity:  a temperature of 100.4 degrees F which occurs on any 2 of the first 10 post-partum days, and (2) other morbidity:  a temperature of greater than 100 degrees F on any 1 of the first 10  post-partum days.  Endometrial and tubal specimens were taken and tested for the presence of bacteria.  In addition, tubal specimens were tested for salpingitis, edema, and perivascular infiltrate.  There was no correlation between the time interval and post-operative morbidity.  Positive endometrial cultures were found in 39.5% of the patients involved, and positive tubal cultures in 28.9%, which showed no correlation with time delay.  There was significantly less histologic salpingitis in cases done within 36 hours after delivery.  There was a correlation between salpingitis and positive tubal cultures.  Post-operative morbidity did not correlate with either abnormal tubal histology or positive tubal cultures.


Complications from Majzlin spring intrauterine device.


Cytology of voided urine in the diagnosis of gynecologic malignancy.


Thrombotic predisposition associated with oral contraceptives.


Mid-trimester abortion with intraamniotic saline and intravenous oxytocin.


Intraamniotic urea for induction of mid-trimester abortion.


Induction of mid-trimester abortion with intrauterine alcohol.


Public health aspects of future ob-gyn services.


Primary vaginal stones.

Primary vaginal stones.


A letter to Anita Sanders' present gynecologist.


Modified cervical block for elective abortion procedures.


Toxemia.

Toxemia.


Neonatal complications.

Neonatal complications.


An expediting procedure for late abortion.


Cervical fistula as a complication of mid-trimester abortion.


Genetic etiology of primary ammenorrhea.


Discharge patterns of the lung stretch receptors and activation of deflation fibres in anaphylactic bronchial asthma.


Temperature and acid-base regulation in the shore crab Carcinus maenas (L.).


The structure and function of the small airways in pinniped and sea otter lungs.


Hypothermal effect on the gas exchange in chicken embryo.


Ventilation measured by body plethysmography in hibernating mammals and in poikilotherms.


Pulmonary respiration and acid-base state in hibernating marmots and hamsters.


Longitudinal forces acting on the trachea.


Significance of the Bohr and Haldane effects in the pulmonary capillary.


The changing face of Texas medicine.

The changing face of Texas medicine.


A model of time-varying gas exchange in the human lung during a respiratory cycle at rest.


Isometric exercise and the cardiac patient.


New criteria for juvenile rheumatoid arthritis.


Complications in surgery for blepharospasm.


Alkaline earth metabolism in adult man. A report prepared by a task group of Committee 2 of the International Commission on Radiological Protection (ICRP Publication 20).


The carcinogenic effects of low level radiation. A re-appraisal of epidemiologists methods and observations.


Dose to standard reference man from external sources of monoenergetic photons.


Comments on "The carcinogenic effects of low level radiation. A re-appraisal of epidemiologists methods and observations".


Childhood cancer following obstetric radiography.


An IC piezoresistive pressure sensor for biomedical instrumentation.


Parameter estimates of a left ventricular model during ejection.


Micropositioner in a closed-loop control system.


Focus-assist device for a flying-spot microscope.


A dendritic compartment model neuron.

A dendritic compartment model neuron.


Amendment of recommendations for standardization of specifications for instruments in electrocardiography and vectorcardiography concerning safety and electrical shock hazards.


Eccentric dipole in a spherical medium: generalized expression for surface potentials.


Equivalent viscosity of plasma and plasma substitutes in oscillatory flow.


A note on Warner's vagus heart rate control model.


A spectral analysis of single motor unit potentials from human extraocular muscle.


Urine leakage detection.

Urine leakage detection.


Blood clotting time and clotting strength measured by a hemotensiometer.


The electrodeacidification of blood.

The electrodeacidification of blood.


Calculation by the method of finite differences of the temperature distribution in layered tissues.


60-HZ interference in electrocardiography.


Source of estrogen production in postmenopausal women.


The effect of glucocorticosteroids on the proliferation and kinetics of promonocytes and monocytes of the bone marrow. To elucidate mechanisms underlying the prolonged monocytopenia induced in the peripheral blood of mice by injection of a subcutaneous depot of hydrocortisone acetate, the effect of this compound on the production of monocytes and their release from the bone marrow was studied. Hydrocortisone was found to cause a rapid reduction of the bone marrow promonocytes to about 65% of their initial number. The number of monocytes in the bone marrow decreased gradually, over a period of 96 h, to 75% of the initial value. The mitotic activity of the promonocytes was not diminished, as judged from the labeling in vitro with [(3)H]thymidine and the DNA-synthesis and cell-cycle times of these cells. The production of monocytes was only moderately diminished, i.e., to about 80% of the normal amount. The release of monocytes from the bone marrow was found to be influenced by hydrocortisone. After in vivo labeling with [(3)H]thymidine the monocyte-labeling indices were initially significantly higher in hydrocortisone-treated than in normal mice. It is concluded that a decreased production of monocytes in the bone marrow cannot account for the prolonged monocytopenia in the peripheral blood after hydrocortisone administration. However, hydrocortisone interferes with the release of newly formed monocytes from the bone marrow, resulting in a prolonged sojourn of these cells in this compartment.


Products of activated lymphocytes. I. The use of radiolabeling techniques in the characterization and partial purification of the migration inhibition factor of the guinea pig. General methods were developed and applied to the biosynthesis and purification of products of activated lymphocytes available in minute quantities. The activity studied here was the migration inhibitory factor (MIF) produced by purified protein derivative (PPD)- or concanavalin A (Con A)-stimulated lymphocytes obtained from one guinea pig or less. The methods selected yielded results in terms of two chemical parameters characteristic of the molecules involved, namely K(d) on Sephadex G-75 and isoionic point, pI, on isoelectric focusing. When supernatants were fractionated on G-75 columns, there were several areas even in control supernatants which produced migration inhibition relative to medium controls. However, in PPD- and Con A-stimulated supernatants, at least one peak of MIF activity was found solely in the stimulated cultures, with a K(d) of 0.15. A double-labeling technique was used to characterize the proteins of this peak. Control, unstimulated cultures were labeled with [(14)C]leucine and stimulated cultures were labeled with [(3)H]leucine. After mixing the supernatants and G-75 filtration, a major "ratiolabeled" broad peak. i.e. one with increased (3)H/(14)C ratio, was found. When a narrow portion of this peak about K(d) 0.15, containing most of the MIF activity, was subjected to analytical isoelectric focusing, all of the label was associated with proteins of lower net charge than albumin. A unique ratiolabeled peak was found in PPD- and Con A-stimulated fractions with a pI of approx. 5.3. A micropreparative isoelectric focusing technique was developed and yielded MIF activity in the same region as the major ratiolabeled peak. Further study will be required to ascertain whether the ratiolabeled protein is MIF. By following the K(d), pI, and (3)H/(14)C labeling ratio, at least 14 products of activated lymphocytes, synthesized either de novo or in increased amounts, could be distinguished.


Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice. Mice were fed diets deficient in a single essential amino acid, and the primary immune responses to inoculation of allogenic tumor cells was measured by in vitro assay of cellular immunity. Moderate reduction of the amino acids phenylalanine-tyrosine, valine, threonine, methionine-cystine, isoleucine, and tryptophane in the diet produced profound depression of hemagglutinating and blocking antibody responses, although cytotoxic cell-mediated immunity remained intact. These diets had previously been shown to result in a selective depression of tumor growth in mice. Limitation of the amino acids arginine, histidine, and lysine in the diets gave rise to only slight depression of the immune responses. These diets had previously been shown to produce a proportional decrease in both tumor growth and host body weight. Moderate leucine restriction resulted in a paradoxical depression of cytotoxic cell-mediated immunity with little effect on serum blocking activity. Slight increases had previously been noted in the weight of tumors in mice fed leucine-restricted diets. Deficiency or imbalance of essential amino acids in the diet may produce profound depression of immune responses and apparent, marked changes in the immune resistance of the host animal to tumors.


The effect of glycerol treatment of voltage-clamped snake muscle fibers. The effect of glycerol treatment on the membrane currents and tension development was studied in voltage clamped snake muscle fibers. In muscle fibers which were exposed for 1 h to a normal saline containing 400 mM glycerol and then returned to a normal medium, graded depolarizations did not accompany contractile responses. However, when the fiber was depolarized to a certain level, an increment of outward current appeared which partially inactivated with time. The threshold for delayed rectification in glycerol-treated fibers was almost the same as that of intact fibers in spite of the absence of contractile tension. The results suggest that the delayed rectification may be attributed at least in part to the surface membrane and that the contractile activation probably does not depend simply on the inactivating outward currents through the delayed rectification channel.


Characteristics of chloride transport in human red blood cells. The efflux of chloride-36 from human erythrocytes under steady-state conditions is a saturable process that is competitively inhibited by bicarbonate and noncompetitively inhibited by acetate. This chloride self-exchange flux is reversibly dependent on the pH of the medium between 5.7 and 9.6 with a maximum flux at pH 7.8. The increase in chloride flux between pH 5.7 and 7.8 is inexplicable by the fixed charge hypothesis. The interpretations are made that chloride transport in human erythrocytes is carrier mediated, that bicarbonate utilizes the same transport mechanism, and that the mechanism can be titrated with hydrogen ions into less functional forms for chloride transport.


Simple stereoscan stage modification to allow the mounting of large specimens.


The structure of Mytilus smooth muscle and the electrical constants of the resting muscle. The individual muscle fibers of the anterior byssus retractor muscle (ABRM) of Mytilus edulis L. are uninucleate, 1.2-1.8 mm in length, 5 microm in diameter, and organized into bundles 100-200 microm in diameter, surrounded by connective tissue. Some bundles run the length of the whole muscle. Adjacent muscle cell membranes are interconnected by nexuses at frequent intervals. Specialized attachments exist between muscle fibers and connective tissue. Electrical constants of the resting muscle membrane were measured with intracellular recording electrodes and both extracellular and intracellular current-passing electrodes. With an intracellular current-passing electrode, the time constant tau, was 4.3 +/- 1.5 ms. With current delivered via an extracellular electrode tau was 68.3 +/- 15 ms. The space constant, lambda, was 1.8 mm +/- 0.4. The membrane input resistance, R(eff), ranged from 23 to 51 MOmega. The observations that values of tau depend on the method of passing current, and that the value of lambda is large relative to fiber length and diameter are considered evidence that the individual muscle fibers are electrically interconnected within bundles in a three-dimensional network. Estimations are made of the membrane resistance, R(m), to compare the values to fast and slow striated muscle fibers and mammalian smooth muscles. The implications of this study in reinterpreting previous mechanical and electrical studies are discussed.


A modified air turbine viscometer.

A modified air turbine viscometer.


Difference-field method for determining electrical conductivity.


Haemolytic factor from bull seminal vesicle fluid: isolation and some properties.


Antiembryonic effect of bull seminal vesicle fluid in mice.


Ultrastructural tail defects in the spermatozoa from two men attending a subfertility clinic.


The importance of serum albumin and metabolic intermediates for capacitation of spermatozoa and fertilization of mouse eggs in vitro.


Free and esterified cholesterol concentrations in the hamster ovary during the oestrous cycle, pregnancy and lactation.


Progress in human fertility control: the coital use of progestagens.


Testosterone levels in intersex goats.

Testosterone levels in intersex goats.


The labelling of living rabbit ova with fluorescent dyes.


Decreased fertility in female mice immunized with a carrier followed by small numbers of spermatozoa.


Mid-term abortion induced in sheep by synthetic corticoids.


The effect of cyproterone acetate on the duration of pregnancy and parturition in mice.


The spermatogenic cycle of the bandicoot, Isoodon macrourus.


The effect of storage of rabbit spermatozoa at -78 degrees C on their subsequent transport and fertility in the rabbit doe.


Changes in the phospholipid composition of bovine spermatozoa during their passage through the male reproductive tract.


Phospholipids released by ram, bull and boar spermatozoa after coldshocking and freezing.


The effect of handling the reproductive tract on tubal transport in the ewe.


The effects of phosphate-buffered medium on preimplantation mouse embryos in vitro.


Development of eight-cell mouse embryos in substrate-free medium.


The effect of interval between milkings on prolactin release and milk production in the cow.


Perinatal behaviour and maternal corticosteroid levels in sheep.


Intra-uterine administration of prostaglandin F 2   during the second trimester of pregnancy; clinical and hormonal results.


Observatons on the luteolytic effects of prostaglandin F 2   during the oestrous cycle and early pregnancy in the ewe.


Luteolysis in the ewe: a study using a radioimmunoassay for prostaglandin F.


Role of utero-ovarian vascular connections in local uterine luteolysis in the rat.


Progestins and progestin metabolites in ovine fetal blood.


The pituitary gland and pregnancy in the marsupial, Macropus eugenii, employing hypophysectomy and radioimmunoassay for gonadotrophin.


Enzymes of intermediary metabolism in the fetal fluids of the tammar wallaby, Macropus eugenii.


The use of plasma oestriols in human pregnancy.


Corticosteroid metabolism in the human feto-placental unit in relation to gestational age.


Human lymphocyte responses during pregnancy.


Oestrogens in the peripheral plasma of the cow about the time of parturition.


The effect of FSH, LH and testosterone on lysosomal enzymes in the rat testis, after post-hypophysectomy regression.


Studies on the male anti-fertility drug 3-chloro-1,2-propanediol.


Testosteone concentrations in the spermatic vein plasma of marsupials.


Carbohydrates of the prostate of marsupials.


A study of the in-vivo incorporation of tritiated uridine by the reproductive tract of the rabbit doe following injection of human chorionic gonadotrophin.


The effect of actinomycin D on the binding of tritiated oestradiol-17  by the mouse vagina.


Induction of parturition in cattle with corticosteroids.


Dynamics of drug dependency.

Dynamics of drug dependency.


Treatment of chemical dependency of the morphine type.


Toxicology vs. the laboratory.

Toxicology vs. the laboratory.


Community abortion services. The role of organized medicine.


Repair mechanisms involved in prophage reactivation and UV reactivation of UV-irradiated phage lambda.


Chromosome aberrations and radiation-induced cell death. I. Transmission and survival parameters of aberrations.


Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival.


Heterogeneous chromosomal radiosensitivity of phytohaemagglutinin-stimulated human blood lymphocytes in culture.


Aberrations induced by fission neutrons in human peripheral lymphocytes.


High association of an HL-A antigen, W27, with ankylosing spondylitis.


pH effect on erythropoietin response to hypoxia.


The community-based medical school--reactions at the interface between medical education and medical care.


A severe blow to hospital planning: "certificate of need" declared unconstitutional.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-1973.


A role for glucagon during infection.

A role for glucagon during infection.


Cardiac arrhythmia in a pregnant asthmatic patient.


Drugged tests.

Drugged tests.


Effectiveness of coronary-care units.

Effectiveness of coronary-care units.


Isoproterenol aerosol not responsible for increased mortality from asthma.


Respiratory "idle volume".

Respiratory "idle volume".


Treatment needed for multiple sclerosis.


Research on prisoners.

Research on prisoners.


Transfer factor and lepromatous leprosy.


Favorable British experience in malpractice.


Compassion transcends specialization.

Compassion transcends specialization.


Discouraging the book thief.

Discouraging the book thief.


Heart attack: changing habits, reducing risks.


Dermatologic manifestations of diabetes and collagen diseases.


Pharmacotherapy of depression.

Pharmacotherapy of depression.


"Post-pill" amenorrhea. Diagnosis and management.


Vitamins and vigor at 65 plus.

Vitamins and vigor at 65 plus.


Proposals for improving ailing health services.


Thyroid scanning.

Thyroid scanning.


Bioengineering in a community hospital. 1. Instrumentation.


Management of thyroid disorders.

Management of thyroid disorders.


Office proctology. Diagnosis and treatment.


A query to radiotherapists.

A query to radiotherapists.


Renin measurements. Use in evaluation of the renal hypertensive suspect.


The subclavian steal syndrome. A clinical approach.


The histological appearance of hyperfunctioning thyroids following various pre-operative treatments.


Thymoma and Hodgkin's disease of the thymus.


The in vitro maturation of the embryonic chicken thymus. II. Development in organ cultures of lymphocytes responsive to phytohaemagglutinin and concanavalin A in vitro.


The specificity of the chromosomal abnormalities in human colonic polyps. A cytogenetic study of multiple polyps in a case of Gardner's syndrome.


Age-adjusted mortality rates for lung cancer plotted against national cigarette consumption.


Transplantable breast tumours in rats. Studies on hormone response.


Comparisons of microfilaria density in blood sampled by finger-prick, venipuncture, and ingestion by mosquitoes.


Development of Brugia pahangi in the flight muscles of Aedes togoi. Ultrastructural changes in the infected muscle fibers and the infecting filarial larvae.


Histologic processes of healing in hepatic injury due to eggs of Schistosoma mansoni in mice following curative chemotherapy.


Immunologic diagnosis of schistosomiasis. II. Further studies on the sensitivity and specificity of delayed intradermal reactions.


Renal manifestations of leprosy: impaired acidification and concentration of urine in patients with leprosy.


Changing pattern of autopsy findings in patients dying of cholera after 1960.


House sparrows, Passer domesticus (L.), as hosts of arboviruses in Hale County, Texas. I. Field studies, 1965-1969.


Pathology of 12 fatal cases of Argentine hemorrhagic fever.


House sparrows, Passer domesticus (L.), as hosts of arboviruses in Hale County, Texas. II. Laboratory studies with Western equine encephalitis virus.


Effect of Marisa cornuarietis on populations of Biomphalaria glabrata in farm ponds of Puerto Rico.


Fatal cerebral myiasis caused by the tropical warble fly, Dermatobia hominis.


Trace determination of mercury in biological materials by flameless atomic absorption spectrometry.


Determination of silicon in natural and pollution aerosols by 14-MeV neutron activation analysis.


Separation of cinchona alkaloids, opium alkaloids, heroin, and related narcotics by dynamic-coating high-speed liquid chromaotgraphy.


The determination of gold in serum by atomic absorption spectrometry with a carbon filament atom reservoir.


Spinal subdural empyema.

Spinal subdural empyema.


A solvent extraction method for the determination of phosphorus-32 in sea water.


Serotonin and platelet function in Duchenne muscular dystrophy.


Acute transverse myelopathy in adults. A follow-up study.


Induced changes of cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure.


Chorea associated with systemic lupus erythematosus. Treatment with haloperidol.


Elevated cerebrospinal fluid vaccinia antibodies in multiple sclerosis.


Metabolism of (I- 14 C)palmitic acid in the developing brain: persistence of radioactivity in the carboxyl carbon.


Determination of isotopic distribution in ( 18 O) glycerol I-phosphate by mass spectrometry.


The effect of concentration of glucagon on output of triglyceride, ketone bodies, glucose, and urea by the liver.


Phospholipid metabolism of stimulated lymphocytes: activation of acyl-CoA:lysolecithin acyltransferases in microsomal membranes.


Study on the new phospholipid, N-acyl-I-alkyl glycerophosphorylethanolamine, from bovine erythrocytes.


Complex lipid synthesis in hamster intestine.


The use of trimethylsilyl ethers in the characterization of natural sterols and steroid diols by gas chromatography-mass spectrometry.


Enzymatic conversion of labeled ketodihydrosphingosine to sphingosine.


Aortic cholesterol esterase: characteristics of normal rat and rabbit enzyme.


Potentialities of lymphocytoid lines in human biochemical genetics.


Somatic cell hybridization as a tool for studying the metabolic disease cystinosis.


Assignment of genes to human chromosomes by somatic cell genetics.


The separation of chromosomes from diploid human lines.


The use of mouse and human cell lines in studying the regulation of immunoglobulin production.


The establishment and use of long-term human lymphocyte cell lines for genetic studies in man.


Application of human long-term lymphocyte cultures to immunologic problems: mediators of cellular immunity.


Diagnostic laparotomy in Hodgkin's disease.


Combination chemotherapy in Hodgkin's disease.


Familial Hodgkin's disease. Occurrence in two brothers.


Clinical results with an extracaval prosthesis and description of a new intracaval filter.


Grandmother's poisoned well: report of a case of methemoglobinemia in an infant in Oklahoma.


Polycythemia vera in Oklahoma City hospitals.


Pyrolysis of phenylalanine, 3,6-dibenzyl-2,5-piperazinedione, and phenethylamine.


Amitriptyline metabolites. Synthesis of (R,S)-(Z)- and (R,S)-(E)- N-methyl(10,11-dihydro-10-hydroxy-5H-dibenzo(a,d)cycloheptene)-  5,  -propylamine.


N-hydroxypteridines structurally analogous to oncogenic N-hydroxypurines. Covalent hydration of 1-hydroxy-2-oxo-1,2-dihydropteridine.


Sterically controlled syntheses of optically active organic compounds. 28. Asymmetric syntheses of amino acids by addition of hydrogen cyanide to the Schiff bases.


N-terminal groups in mass spectrometry of peptides. A study including some new and useful derivatives.


A study of mechanism for the formolysis of a 20 -tosyloxy steroid.


Acid hydrolysis products of DDD and DDT precursors.


Reductive cleavage of phenylhydrazones of  -keto acids to amino acids.


Demographic factors affecting health services utilization: a causal model.


Commercial airlines industry: some lessons for health services planners.


Determinants of medical care utilization: the role of the telephone in total medical care.


Prepaid group practice in Sault Ste. Marie, Ontario. I. Analysis of utilization records.


A proposal for incentive reimbursement for hospitals.


Effect of provider attitudes in community health decision-making.


Nursing: a neglected dimension of the HMO challenge.


Closed panels, professionalism, and the American Dental Association.


Effect of levodopa (L-dopa) on serum growth hormone in children with short stature.


Serial studies of lung volume and VA-Q in hyaline membrane disease.


Medical curriculum--some observations.

Medical curriculum--some observations.


Medical school without walls.

Medical school without walls.


Linkage of biochemical determinants of pathogenicity in staphylococcal isolates.


Fatal septicemia with aeromonas hydrophila.


Ulcerative colitis proximal to carcinoma of the colon.


Pulmonary disease of vascular origin.

Pulmonary disease of vascular origin.


The epidemiology and control of tuberculosis in developed countries.


Multiple education projects for the physician and the public.


Peer review blues.

Peer review blues.


Clinical staging and lymphography in Hodgkin's disease.


Carcinosarcoma of the uterus. Report of a case surviving eleven years.


Snowmobile accidents in central Wisconsin. Experience during the 1970-1971 and 1971-1972 seasons.


Treatment of Hodgkin's disease: surgical role.


The effects of an oral combined contraceptive on plasma levels of glucose, free fatty acids, glycerol, D-  hydroxybutyrate and triglycerides.


The effect of paracervical block on cervical dilatation and uterine activity.


Plasma levels of progesterone and oestradiol after injections of 17 -hydroxyprogesterone caproate during the luteal phase of the normal menstrual cycle.


The effect of normal and abnormal labour on the foetus. A survey.


Equipment for direct FHR monitoring during labor. A comparative artefact study.


Fetal and maternal pH measurements. A basis for common normal values.


Purification of the "pregnancy zone" protein. The "pregnancy zone" protein found in electrophoresis of the serum of pregnant women and after the administration of oral contraceptives was purified from the sera of type 1-1 haptoglobin after gel filtration of Sephadex G-200, chromatography  on DEAE Sephadex and preparative polyacrylamide electrophoresis.  The purified protein had an estimated molecular weight of 326,000, an isoelectric point of 4.7 and a sedimentation coefficient of 12s.  The protein is not placental in origin but the organ of origin is unknown.


Fertility of husbands at homologous insemination.


Determination of plasma human chorionic somatomammotrophin and urinary oestriol in diabetic pregnancies.


The ureterocalyceal system in normal pregnancy. A study using isotope renography and intravenous pyelography.


Experience with Shirodkar's operation and postoperative alcohol treatment.


A new device for vaginal needle aspiration biopsy.


Pregnancy complicated by extreme hyperlipaemia and foam-cell accumulation in placenta.


Changes in uterine volume following the intra-amniotic injection of hypertonic saline. Reply to comments of Dr. Goodlin.


Induction of midtrimester abortion by increasing intra-uterine volume.


Bilateral renal hypoplasia with oligomeganephronia: quantitative and electron microsopic study.


Fibrinolytic activity in patients with acute myocardial infarction.


A simplified method for the cytologic study of body fluids.


Assay of serum nonesterified fatty acids by atomic absorption spectrophotometry.


Type IV hyperlipidemia in the GM 1  gangliosidoses.


The histopathology of gynecomastia.

The histopathology of gynecomastia.


Elevated serum lactate dehydrogenase activity in megaloblastic anemia--some current explanations re-examined.


Ampicillin crystalluria.

Ampicillin crystalluria.


Residency training in clinical chemistry.


Evaluation of a simplified technic for the measurement of aldosterone in human urine.


An improved automated method for determination of serum albumin using bromcresol green.


Spectrophotometric assay of erythrocyte orotidylate decarboxylase.


Rapid detection of candidemia.

Rapid detection of candidemia.


Levels of mercury in urine correlated with the use of skin lightening creams.


Sporothrix whole yeast agglutination test: low-titer reactions of sera of subjects not known to have sporotrichosis.


Relation of diverticulosis of the colon to environmental factors in Greece.


Small intestinal disease, folate deficiency anemia, and oral contraceptive agents.


Drug-induced active chronic hepatitis.

Drug-induced active chronic hepatitis.


Jejunal disaccharidase activity in maturity onset diabetes.


A study of intestinal function and morphology in nonspecific ulcerative colitis in acute phase and remission in India.


Viral hepatitis and agranulocytosis.

Viral hepatitis and agranulocytosis.


Nonfatal venous intravasation from the site of diverticulitis during barium enema examination.


Methyldopa hepatitis. Report of three cases.


Studies of nuclear DNA in vaginal adenosis and clear-cell adenocarcinoma. This study was conducted to determine whether adenosis is a precursor of the clear-cell adenocarcinoma.  3 adenocarcinoma specimens from cases 1, 2 and 3 were taken from radical surgical specimens; specimens from cases 4 and 5 were excisional biopsies of asymptomatic visible lesions of DES (diethylstilbestrol) daughters, while specimen 6 was a radical surgical specimen obtained after an excisional biopsy elsewhere had excised all of the apparent tumor.  All but 1 patient had a history of maternal ingestion of DES.  1 patient with adenocarcinoma was conceived prior to DES use in pregnancy.  Nuclear DNA measurements were made using a Leitz microspectrophotometer and a Leitz monochrometer modified by including substage and field diaphragms.  115 cells were measured from the 3 cases of clear-cell carcinoma, 113 from 3 cases of adenosis.  Aneuploidy was consistently found in the invasive clear-cell carcinoma of the vagina, suggesting that the immediate precursor state should also be in the aneuploid range.  The 3 adenosis specimens however were in the normal diploid to tetraploid range.  The limitations of this study include the small number of cases, and the use of a relatively insensitive method of measuring nuclear DNA which may have produced qualitative changes in chromosomes which could be present in the adenosis.  Physicians are encouraged to give their full cooperation to the Registry for Clear-Cell Adenocarcinoma of the Genital Tract in Young Women by reporting cases of adenosis or clear-cell adenocarcinoma associated with a history of maternal ingestion of DES.


Radiogold treatment of epithelial cancer of ovary: late results.


Effects of luteectomy and progesterone replacement therapy in early pregnant patients.


Ampicillin therapy for Corynebacterium vaginale (Haemophilus vaginalis) vaginitis.


Outpatient therapy of preinvasive cervical neoplasia: selection of patients with the use of colposcopy.


Induction of intrauterine adhesions in the rabbit with autogenous fibroblast implants.


Estriol in pregnancy. II. Daily urinary estriol assays in the management of the pregnant diabetic woman.


Estetrol in molar pregnancies quantitated by a rapid gas chromatographic method in conjunction with estrone, estradiol-17 , estriol, and pregnanediol.


Effect of different doses of ethanol on the milk-ejecting reflex in lactating women. A clinical test was conducted with 40 healthy women 2-8 days following parturition to assess the effect of ethanol on the milk-ejecting reflex.  The women before they were given alcohol were used as their own controls.  The inhibition was found to be better correlated with the dose of ethanol administered than with the blood alcohol concentration measurement conducted at the end of the experiment.  Results are tabulated and graphed.  Ethanol in doses from .5-.93 gm per kilogram produced significant inhibition of the milk-ejecting activity; in doses from 1-1.48, there was an inhibition of the response to suckling; in doses from 1.5-1.9, the strongest inhibition was observed.  The study, thus, confirms earlier findings that ethanol blocks oxytocin release.  The effect was widely variable but definitely dose-related.  It is possible that doses higher than 2 gm per kilogram could completely inhibit the suckling-induced oxytocin release which controls milk-ejecting activity.


Human urine oxytocin levels during pregnancy and labor.


Lack of coagulation defect after terminating second-trimester pregnancy by the catheter technique.


Maternal serum 17 -estradiol levels in normal and complicated pregnancies: a comparison with other estrogen indices of fetal health.


Comparison of maternal serum estriol and urinary estrogen determinations as indices of fetal health.


Length of the intravesical ureter in normal pregnant rabbits and rats.


Amniotic fluid mucoprotein in severe pre-eclamptic toxemia.


Primary transitional cell tumor of the uterine adnexa.


Hemangioma of the Fallopian tube.

Hemangioma of the Fallopian tube.


Evaluation of the amniotic fluid test and its relationship to the respiratory distress syndrome.


Treatment of cervicitis.

Treatment of cervicitis.


Amniotic fluid lecithin-sphingomyelin ratio.


Cervical migration of laminaria tents.

Cervical migration of laminaria tents.


Heparin in disseminated intravascular coagulation.


Fetal bradycardia after paracervical block.


Emergency room treatment of the drug-abusing patient.


Motivation for medicine in the seventies.


Steps in the return to school of children with school phobia.


Patterns of drug abuse among military inductees.


Political psychiatry: the psychiatrist in elective public office.


The Euclid House: a therapeutic community halfway house for prisoners.


Motivational factors in abortion patients. From June 1970 through January 1971, a psychological comparison between 99 single white pregnant women seeking abortion and a control group of 79 single nonpregnant women of similar background showed that, as a group, the women seeking  abortion were no more neurotic than nonpregnant women of the same ages.  Both groups (comprised mainly of college students) were equally informed about contraceptives.  77% of the abortion group used no contraceptives prior to the pregnancy.  82% of the sexually active members of the control group consistently used contraceptives.  Conscious motivational factors, such as guilt over use of contraception, reactions to loss, or severe acting-out character disorders, may have influenced the occurrence of the pregnancy in 40% of the abortion group.  Psychological testing showed that the pregnant group stated themselves as more impulsive and as tending to externalize aggression.


The mystical experience as a suicide preventive.


Aggression and social synergy.

Aggression and social synergy.


Psychiatric assessment of 30 chronic users of cannabis and 30 matched controls.


A preliminary report on multi-image immediate impact video self-confrontation.


Problem formulation: the problem-oriented record.


Follow-up on Baxstrom patients returned to hospitals for the criminally insane.


The writ writer.

The writ writer.


Psyching out Psi.

Psyching out Psi.


The attitudes of patients and aides toward the role of the psychiatric aide.


Self-enucleation: further views.

Self-enucleation: further views.


Indian peyotists and alcohol.

Indian peyotists and alcohol.


Hyperkinetic children and the Staccato Syndrome.


The American Psychiatric Association position statement on peer review in psychiatry.


The American Psychiatric Association position statement on homicide prevention.


The American Psychiatric Association position statement on psychiatrists' relationships with nonmedical mental health professionals.


The American Psychiatric Association position statement on involuntary hospitalization of the mentally ill (revised).


Chemical intolerance to butylated-hydroxyanisole (BHA) and butylated-hydroxytoluene (BHT) and vascular response as an indicator and monitor of drug intolerance.


AMA specialty journals and the crises in health education.


Social class and psychopathology in adoptees. A natural experimental method for separating the roles of genetic and experimential factors.


Depression rating scales. A critical review.


Who listens? Who communicates? How? Styles of interaction among parents and their disturbed adolescent children.


Psychiatry and pseudopsychiatry.

Psychiatry and pseudopsychiatry.


Group therapy as viewed by hospitalized patients.


Transience vs continuance of disturbances in college freshmen.


Resilience of family process. Effect of secobarbital.


Emotional reactions in abortion services personnel.


Hypnosis in the treatment of warts.

Hypnosis in the treatment of warts.


Hallucinogenic drug-induced behavior under sensory attenuation. Prediction of response to psilocybin.


Fat transport in the locust, Locusta migratoria: the role of protein synthesis.


Partial purification and characterization of a fatty acyl monoester lipase from human adipose tissue.


Mesomorphic behaviour of some phospholipids with aliphatic alcohols and other non-ionic substances.


Relationships between fatty acid patterns of serum, hepatic and biliary lecithins in man effect of sucrose feeding.


The Ca 2+ -dependent biosynthesis of lecithin, phosphatidyl-ethanolamine and phosphatidylserine in rat liver subcellular particles.


Selective transfers of acetylenic acids to form lecithins.


Studies on the synthesis of prostaglandins in the vesicular glands of essential fatty acid-deficient and hypophysectomized rats.


Hydrolysis and formation of cholesterol esters with rat liver lysosomes.


Structural features of ring B and the interaction of 20-oxosteroids with cortisone reductase.


Coronary artery disease.

Coronary artery disease.


Interaction of phosphatidylcholine and apolipoprotein-alanine: electron microscopic studies.


Hammer and eye.

Hammer and eye.


Prophylactic antibiotics in arterial surgery: a personal experience covering 218 operations.


Current concepts regarding the classification and prophylaxis of hepatitis.


Consent, confidentiality, the law and adolescents.


What happens to the patient's religion?

What happens to the patient's religion?


Special report on physicians' unions: what they are--recent developments--legal aspects.


Politics and the biomedical perspective.


Budgeting for health.

Budgeting for health.


British government support for research and development--a system in flux and under stress.


Experimental mycoplasma infections as models of rheumatoid arthritis.


Evidence for the suppression of the development of cytotoxic lymphoid cells in tumor immunized mice.


Immunologic models used for the study of rheumatoid arthritis.


Total synthesis of a monocyclic peptide lactone antibiotic, etamycin.


Calorimetric determination of azide-ion binding by ferrihemoglobin A in water and in 5 percent tert-butyl alcohol.


Synthesis of 2-hydroxyquinic and 2-hydroxyepiquinic acids from shikimic acid.


Calcium binding to carbohydrates. Crystal structure of a hydrated calcium bromide complex of lactose.


Structure and absolute stereochemistry of everheptose.


Enzymatic activity and  - 32 P labeling of fluorescent derivatives of cytidine triphosphate and adenosine triphosphate.


One-proton catalysis in the deacetylation of acetyl- -chymotrypsin.


Synthesis and structure of Caulobacter crescentus flagella. During the normal cell cycle of Caulobacter crescentus, flagella are released into the culture fluid as swarmer cells differentiate into stalked cells. The released flagellum is composed of a filament, hook, and rod. The molecular weight of purified flagellin (subunit of flagella filament) is 25,000 as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The formation of a flagellum opposite the stalk has been observed by microscope during the differentiation of a stalked cell in preparation for cell division. By pulsing synchronized cultures with (14)C-amino acids it has been demonstrated that the synthesis of flagellin occurs approximately 30 to 40 min before cell division. Flagellin, therefore, is synthesized at a discrete time in the cell cycle and is assembled into flagella at a specific site on the cell. A mutant of C. crescentus that fails to synthesize flagellin has been isolated.


Comutation in Streptomyces.

Comutation in Streptomyces. Up to 6% of N-methyl-N'-nitro-N-nitrosoguanidine-induced back mutations in the hisA locus of Streptomyces coelicolor were forward mutations (comutations) in another closely linked his locus.


Superoxide dismutase in Bacillus popilliae, a catalaseless aerobe. Bacillus popilliae, a cytochrome-containing aerobic organism that lacks catalase and peroxidase, was examined for superoxide dismutase activity. The activity was quite high relative to a wide variety of organisms previously surveyed and was induced by oxygen. No correlation could be made between superoxide dismutase activity and the unexplained death of this organism after completion of exponential growth.


Differential heat stabilities of Bacillus amylase. Seventeen cultures representing eight strains of Bacillus coagulans and twelve cultures representing eight strains of Bacillus stearothermophilus did not yield a culture that would produce amylase at both 37 and 55 C.


Affective content and contextual constraint in recall by paranoid, nonparanoid, and nonpsychiatric patients.


Obligate thymidine auxotrophs of Pseudomonas acidovorans. The aminopterin technique was adapted for the isolation of thymidine auxotrophs of Pseudomonas acidovorans. All the mutants isolated responded to thymidine but not to thymine.


The concept of mental health as related to sex of person perceived.


Attitudes toward homosexuality: preservation of sex morality or the double standard?


Power of child care worker and therapist figures and their effectiveness as models for emotionally disturbed children in residential treatment.


Effects of an encounter group experience on self-perception and interpersonal relations.


Variables associated with recidivism among juvenile delinquents.


Sexual aspects of Thematic Apperception Test administration: a note on "mature clinicians".


Effects of task familiarity on stress responses of repressors and sensitizers.


Emotional reactions to surgery.

Emotional reactions to surgery.


Relationships among the Edwards Personality Inventory scales, the Edwards Personality Preference Schedule, and the Personality Research Form scales.


Parent behavior correlates of personality traits related to creativity in sons and daughters.


Effects of therapist and patient mood on the therapeutic functioning of high- and low-facilitative therapists.


High school students as mental health aides in the elementary school setting.


Psychological characteristics of problem children at the borderline of mental retardation.


Proxemics in deviant adolescents.

Proxemics in deviant adolescents.


Locus of control among opiate addicts.

Locus of control among opiate addicts.


Comparison of rapid smoking, warm, smoky air, and attention placebo in the modification of smoking behavior.


Modeling, sensitivity training, and instruction: implications for the training of college student volunteers and for outcome research.


Interpersonal competition, overinclusive thinking, and schizophrenia.


Developmental stages and chemical composition in embryos of the cockroach, Diploptera punctata, with observations on the effect of diet.


Ultrastructure of the ejaculatory duct region producing the male housefly accessory material.


Inorganic ion composition of haemolymph of the cecropia silkmoth: changes with diet and ontogeny.


Hydrophobic fluorescence probe studies with poly-L-lysine.


The effect of age, nutritional factors, and gonadal development of the mating behaviour of the face fly, Musca autumnalis.


A model library: community and commission benefit.


Properties of an antigenic glycoprotein isolated from influenza virus hemagglutinin. A purified antigen, HABA protein, has been derived from influenza virus concentrates by extraction with denaturing solvents. The protein lacks hemagglutinating activity but binds completely strain-specific, hemagglutination-inhibiting antibodies and induces neutralizing antibodies in experimental animals. Physicochemical characterization of HABA protein identifies it as a single homogeneous glycoprotein with a molecular weight of 78,000. On dissociation with guanidine or sodium dodecyl sulfate, in the presence of reducing agents, only one size of polypeptide with a molecular weight of the order of 40,000 is characteristic of the preparations. The data indicate that HABA protein is a dimer of HA(1) polypeptide of the influenza virus hemagglutinin substructure, and that only trace amounts of other polypeptides are present.


Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A-NWS (HON1) influenza virus. Genetic recombination of the neurovirulent A/NWS/cc-p (H0N1) and the non-neurovirulent A/Jap.305/57 (H2N2) influenza viruses in which hemagglutinin and neuraminidase were segregated (H0N2, H2N1) were studied for neurovirulence in mice immunosuppressed with cyclophosphamide (CPA) which permitted full expression of virulence. Both H0N2 and H2N1 recombinants replicated in the brain (in contrast to the H2N2 parent) and both produced lethal effects in CPA-treated animals. Therefore we conclude that A/NWS (H0N1) neurovirulence is not exclusively linked with either the hemagglutinin or the neuraminidase of the virus. The H0N2 and H2N1 recombinants have revealed the existence of two separate attributes of neurovirulence: (i) the capacity of virus to initiate intracerebral infection and (ii) the capacity of infection, once initiated, to produce lethal disease. These studies provide further evidence for the polygenic nature of A/NWS neurovirulence.


On the question of crown-gall tumor initiation by DNA of bacteriophage PS8. DNA of Agrobacterium tumefaciens bacteriophage PS8 was isolated by using several procedures. Whole phage and phage DNA were tested for tumor-inducing ability on 10 species of plants with various additions to assist such activity. The reported tumorigenicity of phage PS8 DNA could not be confirmed, and no evidence to implicate phage PS8 involvement in tumor initiation was obtained.


The blind walk faster: orientation and mobility.


Analysis of high-molecular-weight ribonucleic acid associated with intracisternal A particles. Intracisternal A particles, known primarily for their association with various tumors, have been shown to contain high-molecular-weight (HMW) ribonucleic acid (RNA) by velocity centrifugation, using linear glycerol gradients. This HMW RNA is sensitive to ribonuclease digestion and alkali treatment but is resistant to Pronase treatment. By a double-labeling experiment, HMW RNA was shown to be intrinsic to intracisternal A particles and not to have resulted from cytoplasmic polysomal RNA aggregation. By a reconstitution experiment, it was determined that the results were not due to C-type virus contamination. The synthesis of HMW RNA in intracisternal A particles is inhibited by actinomycin D and ethidium bromide. These observations emphasize that there are probably some taxonomic relationships between intracisternal A particles and oncogenic RNA viruses.


Structural organization of murine intracisternal A particles. Isolated murine intracisternal A particles have a distinctive set of structural properties as compared to the recognized oncogenic ribonucleic acid tumor viruses. A particles consist of two closely approximated concentric shells. The outer shell is largely, but not entirely, susceptible to treatment with detergents such as deoxycholate and Triton X-100. The inner shell is resistant to these agents and is stabilized against solubilization by sodium dodecyl sulfate as a result of disulfide bonding between its constituent proteins. The major A particle structural protein (molecular weight approximately 70,000) is contained in the inner shell. A protein component with a molecular weight of about 80,000 may be preferentially concentrated in sites of firm attachment between the inner and outer shells.


Atmospheric pollutants destroyed in an ultra violet scrubber.


Practical system for ployacrylamide gradient gel electrophoresis.


Rapport or manipulation.

Rapport or manipulation.


Practical course in liquid scintillation counting. II. Preparing of samples.


A 6-year study with a 4-year follow-up.

A 6-year study with a 4-year follow-up.


Apparatus for semi-continuous culture of Daphnia.


A new look at an old game. Army attempts at behavioral science.


An interview with Jerome Jaffe, M.D: the United States encounters the drug scene.


Slide cases for cell culture preparations for autoradiography and other procedures.


The future of volunteerism.

The future of volunteerism.


Coronary arterial spasm in Prinzmetal angina. Documentation by coronary arteriography.


Unique experiment in independent travel.


Agencies co-operate in feasibility study.


Lymphocyte-depletion Hodgkin's disease. A clinicopathological entity.


Viral hepatitis, type B (MS-2-strain). Further observations on natural history and prevention.


Selection of unrelated compatible platelet donors by lymphocyte HL-A matching.


Notes of a biology-watcher. Natural man.


Prospects for radiographic intrauterine diagnosis--the syndrome of thrombocytopenia with absent radii.


A rare type of Hodgkin's disease.

A rare type of Hodgkin's disease.


Coronary spasm as a cause of angina.

Coronary spasm as a cause of angina.


A vaccine for viral hepatitis type B appears on the horizon.


Ethics of experiments on children.

Ethics of experiments on children.


Pulsus paradoxus and airways obstruction.


Thrombocyturia after aspirin.

Thrombocyturia after aspirin.


Toxoplasmosis isosporosis.

Toxoplasmosis isosporosis.


Normal vs. pathogenic flora in acute pharyngitis.


Porphyrins in Dubin-Johnson syndrome.

Porphyrins in Dubin-Johnson syndrome.


Cigarettes and benzodiazepines.

Cigarettes and benzodiazepines.


Dosage of lidocaine.

Dosage of lidocaine.


Colchicine for familial Mediterranean fever.


Lead in paint.

Lead in paint.


Waiter's shoulder.

Waiter's shoulder.


In defense of radiation therapy.

In defense of radiation therapy.


Mandatory immunization.

Mandatory immunization.


Medical care in United States and elsewhere.


Who's who in American medicine?

Who's who in American medicine?


Mild anemia accompanied by systemic symptoms.


Post-myocardial infarction ventricular septal defect and ventricular aneurysm. Report of a case with successful repair.


Complete replacement of the ascending aorta and the aortic valve in Marfan's syndrome.


The effects of chronic exercise on cardiovascular function.


The contributions of anesthesiology to medicine: its present status and future role.


Hyperbaric nursing.

Hyperbaric nursing.


Gas gangrene and its management.

Gas gangrene and its management.


More about gangrenes.

More about gangrenes.


A patient with gas gangrene.

A patient with gas gangrene.


Biorhythmics.

Biorhythmics.


In at the deep end.

In at the deep end.


Mental hospitals--have they a future?

Mental hospitals--have they a future?


Streptokinase therapy for deep vein thrombosis.


Michael.

Michael.


Staff side puts it on record.

Staff side puts it on record.


An aid to patient care.

An aid to patient care.


Nursing attitudes in the health care team.


Nursing and the universities.

Nursing and the universities.


Automatic weight control on a rotary tabletting machine using a digital measuring system.


Pharmacognostical study of Hyoscyamus desertorum. I. Morphology and histology of the flower.


Hispidulin-7-glucoside, a minor flavonoid of Trifolium pannonicum L.


The pharmacognosy of the Aspidosperma barks of Brasil.


Spectrophotometric estimation of strychnine in galenical and pharmaceutical preparations.


Phytochemical investigation of Hyoscyamus desertorum.


A new sesquiterpene keto-lactone from Senecio.


Isolation of two flavonoidal principles from Urospermum picroides.


A potential antileukemic substance present in Allium ascalonicum.


Occult rickets and osteomalacia amongst the Asian immigrant population.


Renal amyloidosis--a fourteen-year follow-up.


Cushing's syndrome. An evaluation of the clinical usefulness of urinary free cortisol and other urinary steroid measurements in diagnosis.


Anaemia in the elderly.

Anaemia in the elderly.


Congenital hepatic fibrosis and nephronophthisis. A family study.


Sinu-atrial disorder including the brady-tachycardia syndrome. A review with addition of 11 cases.


Acute mitral regurgitation resulting from ruptured or elongated chordae tendineae. Auscultatory and phonocardiographic findings.


Accidental death toll higher in 1972.

Accidental death toll higher in 1972.


Number of elders growing nationwide.

Number of elders growing nationwide.


Longevity of New York State legislators.


Changes in population profile by age.

Changes in population profile by age.


Long term follow-up study of fifty patients with pancreaticojejunostomy.


Correlation of preoperative lymphocyte reactivity with the clinical course of cancer patients.


A plethysmographic technique for the diagnosis of deep venous thrombosis of the lower extremities.


Radiologic diagnosis of inguinal hernia in children.


Hamartomas of the lung.

Hamartomas of the lung.


Heparin induced thrombocytopenia with thrombotic and hemorrhagic manifestations.


The use of prophylactic antibiotics in patients undergoing cesarean section.


Opening a loop colostomy by a simple method.


Carotid axillary bypass grafts for occlusion of the proximal portion of the subclavian artery.


Surface potassium ion activity of the ischemic kidney.


Surgical exposure for reconstruction of the proximal part of the tibial artery.


Prognosis and surgical pathology of carcinoma of the colon.


Arbovirus heart disease: myocarditis and cardiomyopathy following dengue and chikungunya fever--a follow-up study.


A comparison between the effects of dynamic and isometric exercise as evaluated by the systolic time intervals in normal man.


Aortico-left ventricular tunnel. A clinical and pathologic review of this uncommon entity.


Paralysis of the legs and venous thromboembolism.


Comparison of radioisotopic T-3 and T-4 kits.


Simplified procedure for monitoring heparin therapy.


Carcinoma of the breast associated with pregnancy and lactation.


The effects of lateral postural balancing on gait patterns of blind subjects.


Postoperative hyperamylasemia.

Postoperative hyperamylasemia.


Management of noclostridial crepitant myositis.


Thrombosis and aneurysm of the brachial artery secondary to brachial arteriography.


Analysis of winning times of track races for men in Mexico City 1968 and Munich 1972.


Internal carotid aneurysm.

Internal carotid aneurysm.


Gastrostomy tube migration.

Gastrostomy tube migration.


Gangrene associated with venous tourniquets.


Measurement of trunk lateral flexion: a clinical note.


Gastroesophageal reflux.

Gastroesophageal reflux.


Splenectomy: indications, results and complications in 406 patients.


The corrective therapist in the industrial safety setting.


Central venous pressure monitoring: complications and a new technic.


Surgical patients and drug abuse syndrome.


Epidemiological and ecological study of risk factors for narcotics overdose. IV. Retrospective histopathological study of lungs in cases of fatal narcotism: comparative analysis for potential hypersensitivity reaction.


Vibration-induced arterial shear stress: the relationship to Raynaud's phenomenon.


Differential aerosol challenge studies in byssinosis.


Smoking and lead.

Smoking and lead.


Smoking habits and the leukocyte count.

Smoking habits and the leukocyte count.


Diurnal variation of respiratory function independent of air quality: experience with an environmentally controlled exposure chamber for human subjects.


Comparative decomposition of ozone in the nasopharynx of beagles: acute vs chronic exposure.


Long-term nitrogen dioxide exposure: effects on lung lipids and mechanical properties.


Transplacental passage of demeton in CF-1 mice.


A complex of histones IIb2 and IV.

A complex of histones IIb2 and IV.


Carboxymethylation of the histidyl residues of insulin.


Kinetics and thermodynamics of the   helix leads to   transconformation of poly(L-lysine) and L-leucine copolymers. A compensation phenomenon.


Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships.


4-Sphingenine derivatives in wheat flour lipids.


Kinetic behavior of cytochrome f in cyclic and noncyclic electron transport in Porphyridium cruentum.


Theory of electrophoresis and sedimentation for some kinetically controlled interactions.


Potential energy calculations on phospholipids. Preferred conformations with intramolecular stacking and mutally tilted hydrocarbon chain planes.


Lymphocyte lysosomes and lysosomal enzymes in chronic lymphocytic leukemia.


Crystal structure and molecular conformation of formycin monohydrates. Possible origin of the anomalous circular dichroic spectra in formycin mono- and polynucleotides.


Stimulation of hematopoiesis by femoral marrow curettage in sublethally irradiated mice.


The role of the sinus wall in the passage of erythrocytes through the spleen.


Disturbed bone marrow cell proliferation in primary shunt hyperbilirubinemia.


Histone biosynthesis in pernicious anemia proerythroblasts and megaloblasts.


Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization.


IgG cryoglobulinemia associated with amyloidosis.


Expression and linkage of genes for X-linked hemophilias A and B in the dog.


Defibrination syndrome or?

Defibrination syndrome or?


Parasitisms in domesticated animals in Ontario. I. Ontario Veterinary College Records 1965-70.


Fractured ulna in the horse.

Fractured ulna in the horse.


Intestinal re-entrant cannulation of the horse.


A cervical cyst in a horse.

A cervical cyst in a horse.


Undergraduate veterinary training in community health.


Clinical pharmacology of cyclophosphamide.


Chondral dysplasia induced by zirconium and hafnium.


Comparative studies of subcutaneous and intradermal leukemic tumors in guinea pigs.


Role of hormonal environment, partial hepatectomy, and dose of ethylnitrosourea in renal carcinogenesis.


Radioiron incorporation by a transplantable lymphoid tumor.


Some effects of chlorambucil on the chromatin of Yoshida ascites sarcoma cells.


Effects of 2-acetylaminofluorene on liver cell proliferation after partial hepatectomy of female rats.


The nature of estrogen and prolactin effect on mammary tumorigenesis.


Enhancement of adenovirus transformation by treatment of hamster cells with ultraviolet irradiation, DNA base analogs, and dibenz(a,h)anthracene.


Studies on the quantitative biology of hyperthermic killing of HeLa cells.


Retroperitoneal iliac endarterectomy (a safe revascularization procedure for the poor risk patient).


Influence of drugs and synchrony on the hyperthermic killing of HeLa cells.


Tracheobronchial fiberoscopy.

Tracheobronchial fiberoscopy.


Operating room utilization.

Operating room utilization.


Changing concepts in medical morals.

Changing concepts in medical morals.


Fundamentals of radionuclide liver imaging.


Carbon-14 balance and residues of dichlorvos and its metabolites in pigs dosed with dichlorvos- 14 C.


Metabolism of 1-(4'-ethylphenoxy)-6,7-epoxy-3,7-dimethyl-2-octene (R 20458) in the rat.


Fate of aldrin- 14 C in potatoes and soil under outdoor conditions.


Carbofuran: its toxicity to and metabolism by earthworm (Lumbricus terrestris).


Method for high-speed liquid chromatographic analysis of benomyl and-or metabolite residues in cow milk, urine, feces, and tissues.


Determination of some carbamates by enzyme inhibition techniques using thin-layer chromatography and colorimetry.


Oxidation of amino acids by dimethyl sulfoxide.


Studies of guinea pig complement component C9: reaction kinetics and evidence that lysis of EAC1-8 results from a single membrane lesion caused by one molecule of C9.


Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions.


Dynamics of a salt of (2,4-dichlorophenoxy)acetic acid in fish, water, and hydrosol.


Immunochemical-cytological study of proteins from partially defatted peanuts.


Production of migration inhibitory factor by non-dividing lymphocytes.


Microdetermination of triterpene sapogenin content of Kochia scoparia seed using gas-liquid chromatography.


Detector for phosphine at permissible levels in air.


A measurement of the specificities of antibodies to morphine-6-succinyl-BSA by competitive inhibition of  14 C-morphine binding.


Particle recognition by cultivated macrophages.


A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes.


Carbohydrate and cyclitol content of cannabis.


Recovery of large amounts of antibody from immunized rabbits by multiple non-surgical exchange transfusions.


The effect of in vivo irradiation on macrophage function.


Site of action of cortisol in cellular immunity.


Multiresidue procedure for halo- and nitrophenols. Measurement of exposure to biodegradable pesticides yielding these compounds as metabolites.


Model studies regarding the internal corrosion of tin-plated food cans. 3. On the binding of tin(II) ions and iron(II) ions by sulfur-containing amino acids.


Risk factors in bacterial meningitis: Charleston County, South Carolina.


Stachydrine: content in alfalfa and biological activity in chicks.


Effect of   irradiation and heating on proteolytic activity of meat samples.


Reduction of mercury with cysteine in comminuted halibut and hake fish protein concentrate.


Uptake and metabolism of DDT by six species of marine algae.


Septicemia due to Aeromonas hydrophila: clinical and immunologic aspects.


Gentamicin levels in the human biliary tract.


Experimental Mycoplasma pneumoniae infection of young guinea pigs.


Blood transfusion and volume replacement--the surgeon's viewpoint.


Component therapy.

Component therapy.


The treatment of coagulation factor deficiencies.


Maternal mortality--amniotic fluid embolism successfully treated.


Structure activity correlations of biodegradability of DDT analogs.


Amniotic fluid embolism.

Amniotic fluid embolism.


The role of the private physician in tuberculosis control.


Short-term hospital admission.

Short-term hospital admission.


Vulvovaginitis in a child.

Vulvovaginitis in a child.


Skew deviation.

Skew deviation.


Spinal cord injuries--who does what?

Spinal cord injuries--who does what?


Community preparation for the development of a health maintenance organization network.


The demonstrated effectiveness of cardiopulmonary resuscitation. A three-year experience in a community hospital without house staff. An outcome study.


Combined scalp and skull resection for basal cell cancer.


Early experience with newer agents in bone scanning.


A team approach to renal dialysis in a community hospital.


Angiographic features of ruptured abdominal aortic aneurysm.


Clinical applications of the carotid sinus reflex.


Simultaneous use of warfarin-sodium and dextran 70 to prevent post-operative venous thrombosis in patients with hip fractures. A controlled trial.


Determination of digoxin in plasma by radioimmunoassay.


The future emphasis of mental health treatment.


World-wide errands of mercy.

World-wide errands of mercy.


Retroperitoneal fibrosis due to obsolete sarcoidosis. Report of a case with special reference to etiology.


A methadone maintenance program in a community general hospital: a first year's experience.


Treatment of alcoholism. I.

Treatment of alcoholism. I.


Introduction to a new feature--drug use and abuse.


Recent activities of the medical and chirurgical faculty in the control of drug abuse.


Pre-hospital management of acute myocardial infarction.


Definitive therapy in cardiopulmonary resuscitation.


Computer handling of coronary care unit data.


The role of the community hospital in internal medical residency programs.


Continuing education opportunities for physicians in Ohio.


E.N.T. case of the month.

E.N.T. case of the month.


Technics, problems, and gains in interviewing next of kin. An environmental study.


Pseudotumor of the colon.

Pseudotumor of the colon.


Maternal mortality report for Ohio--1970.


The Ohio program for peer review--MAI-PSRO.


Hahnemann-Wilkes program. Six-year plan to train family physicians.


Student program spurs family practice interest.


In training medical personnel. Regional solution given for national problem.


Student says MECO fills a need.

Student says MECO fills a need.


Lidocaine blood levels in patients with acute myocardial infarction.


Clinical experience with silicotuberculosis.


Advances in clinical radiation therapy.

Advances in clinical radiation therapy.


How to collect fees painlessly.

How to collect fees painlessly.


Physician continuing education requirements.


Dental caries.

Dental caries.


High urinary diversion by retroperitoneal jejunal conduit: technic and rationale.


Training or free labour?

Training or free labour?


Treatment of advanced carcinoma of the larynx.


Breast reduction and facial box frame fixation.


Thrombophlebitis: results of a prospective study.


Spinal stenosis.

Spinal stenosis.


Treatment of experimental acute pancreatitis with 5-fluorouracil (5FU).


Pyrantel pamoate for human hookworm infection.


Diffuse intravascular coagulation in meningococcaemia. A case report.


Capillaria hepatica infestation in a child.


Vascular effects of gastrojejunostomy on peptic ulceration.


Systemic lupus erythematosus in Cape Town.


Disseminated intravascular coagulation in acute alcoholic liver disease.


Gastric acid output in Indians with duodenal ulcers.


Gastric acid output in normal Indians.

Gastric acid output in normal Indians.


Carcinoma of the corpus uteri: the cinderella of cancer therapy.


Aortic-pulmonary window.

Aortic-pulmonary window.


Brain scintigraphy in the diagnosis of intracranial lesions. Comparative scanning with  169 ytterbium diethylenetriaminepenta-acetic acid and  203 mercury chlormerodrin.


Diagnostic accuracy of three tests for evaluating the thyroid status. Results of the in vitro assessment of thyroid function and of the 24-hour  131 I-uptake of the thyroid gland.


The enzymatic debridement of burns.

The enzymatic debridement of burns.


Ecology and population.

Ecology and population.


Size and shape in biology.

Size and shape in biology. Arguments based on elastic stability and flexure, as opposed to the more conventional ones based on yield strength, require that living organisms adopt forms whereby lengths increase as the (2/3) power of diameter. The somatic dimensions of several species of animals and of a wide variety of trees fit this rule well. It is a simple matter to show that energy metabolism during maximal sustained work depends on body cross-sectional area, not total body surface area as proposed by Rubner (1) and many after him. This result and the result requiring animal proportions to change with size amount to a derivation of Kleiber's law, a statement only empirical until now, correlating the metabolically related variables with body weight raised to the (3/4) power. In the present model, biological frequencies are predicted to go inversely as body weight to the (1/4) power, and total body surface areas should correlate with body weight to the (5/8) power. All predictions of the proposed model are tested by comparison with existing data, and the fit is considered satisfactory. In The Fire of Life, Kleiber (5) wrote "When the concepts concerned with the relation of body size and metabolic rate are clarified, . . . then compartive physiology of metabolism will be of great help in solving one of the most intricate and interesting problems in biology, namely the regulation of the rate of cell metabolism." Although Hill (23) realized that "the essential point about a large animal is that its structure should be capable of bearing its own weight and this leaves less play for other factors," he was forced to use an oversimplified "geometric similarity" hypothesis in his important work on animal locomotion and muscular dynamics. It is my hope that the model proposed here promises useful answers in comparisons of living things on both the microscopic and the gross scale, as part of the growing science of form, which asks precisely how organisms are diverse and yet again how they are alike.


A serial dilution protamine sulphate test for detecting fibrin degradation products.


Pyrethroid insecticides: esterase cleavage in relation to selective toxicity. The ester group of primary alcohol chrysanthemates is cleaved by mouse hepatic microsomal esterases, more rapidly for the (+)-trans than for the (+)-cis isomers. Substrate-specificity and inhibition studies in vivo establish that these pyrethroid-hydrolyzing esterases probably contribute to the low mammalian toxicity of bioresmethrin and other (+)-trans chrysanthemate insecticide chemicals derived from primary alcohols.


Oxygen dissociation in human erythrocytes: its response to hyperbaric environments. Hyperbaric nitrogen at a pressure of 100 atmospheres increases significantly the affinity of erythrocytic hemoglobin for oxygen. This results in oxygen dissociation curves which are shifted to lower than normal oxygen partial pressures. The pressure effect is completely reversible and can therefore be observed only during exposure of the blood cells to the hyperbaric gas.


Camptothecin blocks memory of conditioned avoidance in the goldfish. Intracranial injection of 10 to 75 micrograms of camptothecin, a plant alkaloid that blocks RNA synthesis in eucaryotic cells, blocks incorporation of tritiated uridine into RNA in the goldfish brain. Injection of 10 to 50 micrograms of the drug within 1.5 hours of training results in greatly diminished memory, tested 1 week later. Injection of the drug 5 or 24 hours after training produces no measurable effect on retention of the learned response.


On habituation in the cochlear nucleus.

On habituation in the cochlear nucleus.


Analgesic strength of 33 percent nitrous oxide: a signal detection theory evaluation. Radiant heat stimulation was applied to volunteers and rating scale responses were obtained to assess the analgesic properties of 33 percent nitrous oxide. The methodology of signal detection theory was applied to the data to demonstrate that nitrous oxide reduces both sensitivity to pain and willingness to report pain. This method is superior to threshold estimation for the evaluation of analgesics.


Interaction between the utricles and the horizontal semicircular canals. I. Unilateral selective sectioning of the horizontal ampullar nerve followed by tilting around the longitudinal axis.


Electronystagmographic findings in multiple sclerosis.


Revised normative standards of performance of men on a quantitative ataxia test battery.


Microfilm storing technique in electronystagmography. Two years of experience.


Temporal integration of acoustic energy in patients with presbyacusis.


Nystagmus responses during triangular waveforms of angular velocity about the Y- and Z-axes.


Shiver-audiometry in the conditioned guinea-pig (simplified Anderson-Wedenberg test).


Transtracheal cervical approach for operating on severe intrathoracic tracheal stenosis following assisted respiration.


The role of the surface tension and the contact angles of perilymph in stapes surgery.


Separate recording of the movements of the human eyes during parallel swing tests.


Rocky Mountain spotted fever in Clermont County, Ohio: description of an endemic focus.


Serologic prevalence of Q fever in the state of Punjab, India.


A survey of hearing loss in school children residing in the London borough of Harrow. I. Methodology.


Family studies of a Lesch-Nyhan patient from an isolated Canadian community.


Differences in the twinning trends between Finns and Swedes.


The genetic structure of a tribal population, the Yanomama Indians. 8. Dermatoglyphic differences among villages.


Population studies of pepsinogen polymorphism.


Vasomotor sensitivity to alcohol in diverse Mongoloid populations.


Sickling rates and heterozygotic frequencies under differential fitness.


Therapies. A clear and present danger.

Therapies. A clear and present danger.


Assignment of the genes for malate oxidoreductase decarboxylating to chromosome 6 and peptidase B and lactate dehydrogenase B to chromosome 12 in man.


Ethical standards as an independent variable in psychological research.


Social unrest. Powerlessness and-or self-direction?


Oxidation of biphenyl by a Beijerinckia species.


Affinity chromatography purification of penicillinase of Bacillus licheniformis 749-C and its use to measure tuurnover of the cell bound enzyme.


Interaction of calcium with mitochondria isolated from Ehrlich ascites tumour cells.


The active site of acetylcholin esterase probed by a photochromic ligand.


Purification of cytochrome P-450 from bovine adrenocortical mitochondria.


The effect of thiols on the dehalogenation of 5-iodo and 5-bromouracil.


Involvement of poly-A in selective gene expression: suppression of enzyme induction in neural retina by inhibitors of poly-A synthesis.


Correlation of rat liver membrane binding of polysomes in vitro with function of the complexes formed.


Fluorometric assay of secondary amino acids.


Comparison between the electron transfer reactions from free radicals and their corresponding peroxy radicals to quinones.


Selective modification of tyrosine and cysteine residues in aspartate aminotransferase from pig heart cytosol.


The reduction of cobalamin. A pulse radiolysis study.


Mitochondrial K +  transport: effect of N-ethyl maleimide on 42 K  flux.


A role for amino acids in the induction of deoxyribonucleic acid synthesis in liver.


Synaptic plasma membrane protein synthesis: selective inhibition by chloramphenicol in vivo.


Template-specific stimulation of RNA synthesis by phosphorylated non-histone chromatin proteins.


Changes in template activity of rat ventral prostate chromatin after brief or prolonged in vivo exposure to androgen: evidence for a succession of chromatin "conformers".


Specific coagulation factor adsorption to insoluble heparin.


Glycoprotein biosynthesis: folic acid effects on glycoprotein: glycosyl transferase activities of rat kidney and liver.


Evidence that nuclear genes code for several chloroplast ribosomal proteins.


Altered respiration and proton permeability in liver mitochondria from genetically dystrophic mice.


A model for the tertiary structure of tRNA.


On the mechanism of 11-hydroxylation of lauric acid by rat liver microsomes.


Identification of a multienzyme complex synthesizing fatty acids in the actinomycete Streptomyces erythreus.


A cross-linking study of the beef erythrocyte membrane: extensive interaction of all the proteins of the membrane except for the glycoproteins.


Qualitative differences in chromatins of adult tissues demonstrated by action of DNase.


Histones isolated from human parotid fluid.


A syn conformation for inosine, the wobble nucleoside in some tRNA's.


Stimulation by insulin of rat liver  -hydroxy- -methylglutaryl coenzyme A reductase and cholesterol-synthesizing activities.


Terminal riboadenylate transferase: a polyadenylate polymerase from calf thymus gland.


Isolation of lipids from plasma by affinity chromatography.


The solubilization and partial characterization of pea RNA polymerases.


Protein binding by agarose carrying hydrophobic groups in conjunction with charges.


Mode of action of the antibiotic X-537A on mitochondrial glutamate oxidation.


Large-scale photosynthetic production of carbon-13 labeled sugars: the tobacco leaf system.


Partial purification of a translational repressor mediating hemin control of globin synthesis and implication of results on the site of inhibition.


Entropy contributions to rate accelerations of intramolecular reactions in water vs non-structured solvents.


Solubilization and partial purification of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase.


The effect of ruthenium red on the uptake and release of Ca 2+  by mitochondria.


Physical studies of chloroacetaldehyde labelled fluorescent DNA.


Determining the availability of activated amino acids for solid phase peptide synthesis.


A molecular orbital study on the conformation of enniatin B.


The role of hypophyseo-adrenocortical system in the regulation of enzyme monoamine oxidase in rabbit foetuses.


An uncommon inotropically active peptide from dog blood plasma.


Stimulation of rat liver microsomal UDP-N-acetylglucosamine: glycoprotein N-acetylglucosaminyltransferase by carboxymethylcysteine-ribonuclease A.


Extramitochondrial location of the minor alanine-specific tRNA stimulatory to hemoglobin formation in the chick blood islands.


Endogenous alanine, glutamate, aspartate, and glutamine in the perfused guinea-pig heart: effect of substrates and cardioactive agents.


Paradoxical inhibition of phosphorylase by pyridoxal phosphate. 3. Sequence of amino acids at site of reaction.


Inhibition of the formation of tetrahydroisoquinoline alkaloids in brain homogenates.


Determination of cellulase activity using hydroxyethylcellulose as substrate.


Cyanogen bromide fragments of rabbit skeletal tropomyosin.


Determination of Na + , K + , Mg 2+ , Cu 2+ , Zn 2+ , and Mn 2+  in rat brain regions.


Amount of  14 C assimilated in different organs and tissues of the rat after a single injection of (U- 14 C)glucose.


An idea whose time has come.

An idea whose time has come.


A multi-purpose miniature computer for clinical applications.


Modified glucose oxidase method for determination of glucose in whole blood.


Urinary guanidinoacetate-guanidinosuccinate ratio: an indicator of kidney dysfunction.


Evaluation of the Delves micro system for blood lead analysis.


Ultramicro method for determination of iron in serum with the graphite furnace.


Simple gas-liquid chromatographic method for confirming the presence of alkaloids in urine.


A source of variation in the gas-chromatographic assay of phenobarbital treated with trimethylanilinium hydroxide.


Theoretical considerations and models of red and white cell pentose cycles.


Intra-articular median nerve entrapment with dislocation of the elbow.


A comparative analysis of lumbar disk disease treated by laminectomy or chemonucleolysis.


Posterior buttock pain following total hip replacement. A case report.


Tuberculosis of the first cervical vertebra.


Wrist arthroplasty in rheumatoid arthritis.


Immediate open reduction and internal fixation of severely displaced supracondylar fractures of the humerus in children.


Recurrent traumatic dislocation of the hip in children.


Roentgenographic assessment of soft tissue medial release ooperations in club foot deformity.


The inter-relationship between vertebral fractures and osteoporosis.


Contact dermatitis to resin-containing casts.


The role of phospholipids in biological calcification: distribution of phospholipase activity in calcifying epiphyseal cartilage.


Changes in bone mass in alcoholics.

Changes in bone mass in alcoholics.


The development of osteoporosis. A hypothesis based on a study of human bone structure.


Synovial hemangioma of the knee joint. A review of previously reported cases and inclusion of two new cases.


Production of radiosulphate and radioselenate, and their reutilisation following injection of  35 S-cystine and  75 Se-selenocystine.


The effect of ephedrine on the response to epinephrine in normal men.


Variation in ragweed pollen concentration to a height of 108 meters.


Arthrodesis of the shoulder.

Arthrodesis of the shoulder.


Conditions of the hip associated with hemoglobinopathies.


Inhibition of histamine-induced airway constriction by ascorbic acid.


Opposing actions of calcitonin and cortisone upon osteogenesis in a heterotopic site.


Reproducibility of allergy epicutaneous test techniques.


Mechanism of action of mineral oil adjuvants. I. Conditions influencing the in vitro stability of water-in-oil emulsions.


Ischemic contracture local in the hand. A complication of cardiac catheterization.


An allergic reaction after internal fixation of a fracture using a vitallium plate.


Pathologic fracture from metastatic malignant melanoma.


The growth cartilage plate of the rat rib: cellular differentiation.


Forensic science. A course for the January interim.


A histologic and hemodynamic study of the toxic effects of monomeric methyl methacrylate.


Stomach upset caused by aspirin. Illustrating principles of acid-base equilibrium and solubility.


The aspirin project. Laboratory experiments for introductory chemistry.


The classic: hip-joint involvement in Gaucher's disease.


Osteoarthrosis at the hand skeleton in primary osteoarthrosis of the hip and in normal controls.


Alcoholism and its effect on the human hip.


"Mere" exposure versus familiarity, with implications for response competition and expectancy arousal hypotheses.


Care of the rheumatoid hip.

Care of the rheumatoid hip.


Neuropathic injuries of the hip.

Neuropathic injuries of the hip.


Brushite octacalcium phosphate, and carbonate-containing apatite in bone.


No sparing of function following serial posterior neodecortication in rats given interoperative training.


Hip problems in fibrous dysplasia.

Hip problems in fibrous dysplasia.


Effects of maternal separation and maternal disturbance on offspring growth and behavior in rats.


The role of verbal reinforcement in hypnosis.


Effectiveness of diazepam and methylphenidate in multiple dosages in modifying infant trauma effects.


Chronic effects of a single nitrogen mustard injection on the activity response of albino rats.


The hip in Gaucher's disease.

The hip in Gaucher's disease.


Personal factors in human learning. II. Learning ability and subjective stress.


AMA conference to seek improved rural health care.


The A.B.C's of mechanical ventilation. II. The dilution mixing process.


The removal and displacement of the thiazolidine ring of penicillin. I. 3-acylaminoazetidinone and 3-acylamino-4-phenylthioazetidinone.


Prostanoic acid chemistry. II. Hydrogenation studies and preparation of 11-deoxyprostaglandins.


Synthesis of 6-methylthiopenicillins and 7-heteroatom-substituted cephalosporins.


Oligonucleotide synthesis. 3. Enzymatically removable acyl protecting groups.


Nucleosides. XVI. The synthesis of 2',3'-dideoxy-3',4'-didehydro nucleosides.


Pre- or post-operative start of anticoagulation prophylaxis in patients with fractured hips?


Intraspinal vascular malformations.

Intraspinal vascular malformations.


Alterations of rat liver lysosomes and smooth endoplasmic reticulum induced by the diazafluoranthen derivative AC-3579. II. Effects of the drug on phospholipid metabolism.


Granulomatous hepatitis and prolonged fever of unknown origin: a study of 13 patients.


Industrial therapy at Friern Hospital.

Industrial therapy at Friern Hospital.


The Alström syndrome. Report of three cases with further delineation of the clinical, pathophysiological, and genetic aspects of the disorder.


The magic of dermatology. 5. Malignant diseases of the skin.


Infection of the eye.

Infection of the eye.


Thoracotomy for removal of undiagnosed schwannoma with nursing care complicated by leakage of cerebrospinal fluid.


The hours between.

The hours between.


Education of nurses and health visitors in group practice.


George.

George.


The nurse as a counsellor.

The nurse as a counsellor.


The mass media in nurse education.

The mass media in nurse education.


Working in a rehabilitation centre.

Working in a rehabilitation centre.


Objective testing in nurse education.

Objective testing in nurse education.


Cottage hospital--in touch with the community.


Guardianship programme in a mental subnormality hospital.


Where have all the nurses gone?

Where have all the nurses gone?


'Miners prefer women'.

'Miners prefer women'.


Children in hospital in Wales.

Children in hospital in Wales.


In the money: industrial nursing at the Royal Mint.


Geriatric day centre in North Wales.

Geriatric day centre in North Wales.


Sex change for a night nurse.

Sex change for a night nurse.


Introducing a central sterile supply system to a rural community.


Response latency models for signal detection.


On peripheral and central processes in vision: inferences from an information-processing analysis of masking with patterned stimuli.


Studies of portal circulation after intrasplenic injection of radionuclides by using a scintillation camera.


Modification of cancer cells radiosensitivity. II. Influence of the crabtree effect on radiosensitivity of Yoshida ascites sarcoma cells.


The amateur scientist. Machines that work like muscles, and how Maxwell's demon was captured in a bottle.


The molecule of infectious drug resistance.


The task of medicine.

The task of medicine.


The lung of the newborn infant.

The lung of the newborn infant.


Cholesterol hydroperoxide formation in red cell membranes and photohemolysis in erythropoietic protoporphyria. 3beta-Hydroxy-5alpha-hydroperoxy-Delta(6)-cholestene is produced in protoporphyrin-containing red blood cell ghosts irradiated with approximately 400-nanometer light in the presence of oxygen. Incorporation of this cholesterol photooxidation product into normal red blood cells leads to increased osmotic fragility and eventual hemolysis. These results may be relevant to photohemolysis associated with erythropoietic protoporphyria.


Detection of inborn errors of metabolism: galactosemia. Radioautography of cultured, human, galactosemic and nongalactosemic cells shows that, in the presence of 0.05M D-galactono-gamma-lactone, the former incorporate much less galactose in acid-insoluble form than the latter. Presumably the lactone inhibits incorporation of the labeled galactose into pathways which do not require galactose-1-phosphate uridylyltransferase activity. Definite differences between the galactosemic and nongalactosemic condition can be demonstrated with as few as 100 to 1000 cells. This approach may be useful in facilitating prenatal detection of several kinds of inborn errors of metabolism.


Fluid shifts associated with gas-induced osmosis. It has been proposed that equilibration of nitrous oxide with blood plasma increases osmotic pressure and thereby causes hemodilution. However, calculations show that the 250-torr osmotic gradient produced by 0.7 atmosphere of nitrous oxide dissolved in blood plasma (separated from the other body fluids by a membrane permeable only to water) would be eliminated by a water shift which would dilute the plasma by only 4 percent. Permeability of the membrane to nitrous oxide would further reduce the shift. In vivo measurements confirmed the smallness of any osmotically induced shifts by demonstrating no significant transient changes in hematocrit value when 0.7 atmosphere of nitrous oxide was added to or removed from an inhaled anesthetic mixture in man. These results cast doubt on the suggestions that gas-induced osmosis is an important factor in dysbarism or in clinical anesthesia.


Biological activity of insulin-sepharose?