Hypocomplementemia of membranoproliferative nephritis. Dependence of the nephritic factor reaction on properdin factor B. Membranoproliferative nephritis in children is frequently associated with a hypocomplementemia produced at least in part by C3 breakdown mediated by a circulating anticomplementary factor known as C3 nephritic factor (C3NeF). C3 breakdown by this factor in vitro requires the presence of a pseudoglobulin cofactor and magnesium. The present study provides evidence that properdin factor B (C3 proactivator) is activated in the nephritic factor reaction and is the direct mediator of C3 breakdown by C3NeF. Depletion of factor B from mixtures of normal human serum (NHS) and plasma from a patient with membranoproliferative nephritis (MPP), either by heating or by immune equivalence absorption, blocks C3 breakdown by C3NeF. Addition of purified factor B to these mixtures restores the anticomplementary effect. When purified factor B is added to mixtures of MPP and purified C3, breakdown also occurs. Associated with the C3 breakdown is a change in the electrophoretic mobility of factor B from the beta to the gamma position, a shift which has been associated with cleavage activation of the molecule. Further, serum factor B levels are often low in patients with membranoproliferative nephritis and bear a rough inverse correlation with C3NeF levels. It thus appears that factor B is the previously described heat-labile C3NeF cofactor. Whether the C3NeF reaction proceeds via a pathway comparable to that activated by the cobra venom factor or via that activated by zymosan or inulin cannot be determined from the present data.


Transverse spread and longitudinal dissociation in the distal A-V conducting system. Isolated preparations of portions of the canine intraventricular conducting system were studied by microelectrode techniques in order to determine the nature of transverse spread and longitudinal dissociation of impulses in bundle branches and false tendons. Driving stimuli were delivered to an eccentric location on normal conducting tissue, and the arrival times of the propagating impulses were mapped along the length and width of the bundle branch, or along the false tendon ipsilateral and contralateral to the site of stimulation. The difference between the arrival times on the two sides was found to decrease progressively as a function of distance from the site of stimulation, the data suggesting that transverse spread of impulses involves propagation through transverse crossover points between the longitudinally oriented conducting elements. Impulses originating eccentrically became uniformly conducted across the transverse axis of bundle branches 8-15 mm from the level of the stimulating electrode, and of false tendons 2-4 mm from the stimulus site. True longitudinal dissociation, producing conduction maps different from those representing normal transverse propagation, was seen occasionally in tissue having longitudinally oriented strips of abnormal tissue. However, early premature stimulation commonly resulted in longitudinal temporal dissociation of the premature responses, possibly due to functional block in the transverse crossover fibers.


Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. The cellular character of the adipose tissue of 21 nonobese and 78 obese patients has been examined. Adipose cell size (lipid per cell) was determined in three different subcutaneous and deep fat depots in each patient and the total number of adipose cells in the body estimated by division of total body fat by various combinations of the adipose cell sizes at six different sites. Cell number has also been estimated on the basis of various assumed distribution of total fat between the subcutaneous and deep fat depots. Obese patients, as a group, have larger adipose cells than do nonobese patients; cell size, however, varies considerably among the fat depots of individuals of either group. The variation in cell size exists not only between, but also within subcutaneous and deep sites. Estimates of total adipose cell number for a given individual based upon cell size can, therefore, vary by as much as 85%. On the basis of these studies it is suggested that the total adipose number of an individual is best and most practically estimated, at this time, by division of total body fat by the mean of the adipose cell sizes of at least three subcutaneous sites. IRRESPECTIVE OF THE METHOD BY WHICH TOTAL ADIPOSE CELL NUMBER IS ESTIMATED, TWO PATTERNS OF OBESITY EMERGE WITH RESPECT TO THE CELLULAR CHARACTER OF THE ADIPOSE TISSUE MASS OF THESE PATIENTS: hyperplastic, with increased adipose cell number and normal or increased size, and hypertrophic, with increased cell size alone. These two cellular patterns of obesity are independent of a variety of assumed distributions of fat among the subcutaneous and deep depots. When these different cellular patterns are examined in terms of various aspects of body size, body composition, and the degree, duration, and age of onset of obesity, only the latter uniquely distinguishes the hyperplastic from the hypertrophic: hyperplastic obesity is characterized by an early age of onset, hypertrophic, by a late age of onset. These studies indicate that there are two distinct periods early in life during which hypercellularity of the adipose tissue are most likely to occur: very early within the first few years, and again from age 9 to 13 yr.


Diurnal variation in the responsiveness of human subjects to human growth hormone. The objective of this study was to compare the responsiveness of human subjects to the anabolic effects of human growth hormone (HGH) administered at 8 a.m. or at 11 p.m. Three doses of HGH were used: A, 0.0168 U/kg body weight (BW)(3/4) per day; B, 0.0532 U/kg BW(3/4) per day; C, 0.168 U/kg BW(3/4) per day. The effect of each dose on daily balances of N, P, Na, and K and on BW was measured. The subjects were of two groups: (a) seven GH-deficient children, of whom three were deficient in ACTH; and (b) three patients with limb-girdle dystrophy. ACTH-deficient patients in group (a) received exogenous cortisol at 7 a.m. In all 10 subjects, the anabolic effects of dose C, and sometimes of B and A, administered at 11 p.m. were significantly (P < 0.05) greater than when administered at 8 a.m. In these experiments plasma cortisol concentration averaged 3 times greater at 8 a.m. than at 11 p.m. In the next experiments, exogenous cortisol was administered to the three ACTH-deficient patients at 10 p.m. and the responsiveness to HGH injected at 11 p.m. vs. 8 a.m. was again compared. Under these conditions, when plasma cortisol concentration averaged 3 times greater at 11 p.m. than at 8 a.m., HGH injected at 8 a.m. caused significantly greater anabolic responses than HGH injected at 11 p.m. These findings indicate that the magnitude of the anabolic response to exogenous HGH is inversely related to the plasma cortisol concentration at the time of HGH injection.


Formation of prostaglandins during the aggregation of human blood platelets. Prostaglandins E(2) and F(2alpha) were formed in response to ADP, L-epinephrine, or collagen by human platelets suspended in plasma containing citrate anticoagulant and stirred at 37 degrees C. The prostaglandins formed by platelets in response to collagen were rapidly released and the amounts formed were proportional to the amount of collagen added. The formation of the prostaglandins was associated with the single wave of aggregation induced by collagen or the second wave of aggregation induced by epinephrine. The above findings are discussed with reference to published studies on the biochemical changes occurring during platelet aggregation. It is suggested that the formation and release of prostaglandins is associated with the secretion of endogenous ADP and 5-hydroxytryptamine.


Changes in sucrase, enterokinase, and peptide hydrolase after intestinal resection. The association of cellular hyperplasia and adaptation. In a study of changes in digestive enzymes after massive intestinal resection and the mechanisms by which such changes occur, rats were sacrified 4 wk after removal of the proximal two-thirds of the small intestine. Alterations in the mucosal levels of sucrase, enterokinase, and dipeptide hydrolase (L-leucyl-L-alanine substrate) were examined in the light of associated changes in protein. DNA and wet mucosal weight, measured in standardized gut segments from various regions of intestine. Metabolic studies showed that normal growth patterns were reestablished after the operation but significant elevations in stool weight and fecal nitrogen occurred in the second postoperative week, falling towards normal by the 4th wk. In standard gut segments wet weight of mucosa, protein, and DNA rose, especially in distal segments, DNA increasing disproportionately. Mucosal levels of the proximally distributed and membrane-bound enzymes, sucrase and enterokinase, showed similar patterns of change: when enzyme activity was expressed in terms of the total per segment, proximally there were considerable increases in both enzymes, but, expressed in terms of specific activity, that of sucrase fell and that of enterokinase was unaltered. By contrast, the largely soluble and more distally distributed dipeptide hydrolase increased more in distal segments and the increases in total activity were accompanied by lesser increases in specific activity. However, in spite of increases in total activity, enzyme activity per milligram DNA fell by over 50% in postanastomotic segments. Subcellular distribution studies showed no change in the percentage of the total activity which was membrane-bound and zymograms confirmed that no new dipeptide hydrolase had appeared after resection. It is concluded that increases in the segmental totals of various enzymes seen after resection are achieved by disproportinate increases in the number of mucosal cells per segment and that the greatest change in a particular enzyme occurs in the region where the enzyme is normally found in highest concentration.


Dietary-induced variation of hypoxanthine-guanine phosphoribosyl transferase activity in patients with the Lesch-Nyhan syndrome. We have studied three patients with the Lesch-Nyhan syndrome to assess the effect of dietary purines on erythrocyte hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity. During dietary purine restriction HGPRT activity rose in all three patients; resumption of normal dietary purine intake or the addition of adenine (10 mg/kg per day) to a purinefree diet resulted in a fall in HGPRT activity. These changes in enzyme activity appeared to be due to an activation or inactivation of the mutant enzyme without a change in the half-life or absolute amount of HGPRT enzyme protein.


Body composition and fat depot weights of rats as influenced by ration fed dams during lactation and that fed rats after weaning.


Relationship between postprandial plasma volatile fatty acids, glucose and insulin levels in sheep fed different feeds.


Adaptation of rumen microorganisms to biuret as an NPN supplement to low quality roughage rations for cattle and sheep.


Effect of vitamin E and selenium on tissue antioxidant status of rats.


Effect of chromium and tungsten on L-ascorbic acid metabolism in rats and chicks.


Effect of adding varying levels of lysine or delactosed demineralized whey to wheat flour on growth and body composition of young rats.


Effect of infused glutamine on uric acid synthesis in chickens fed high and low protein diets.


Absorption and secretion of fatty acids and bile acids in the intestine of the laying fowl.


Effect of zinc deficiency and wounding on DNA synthesis in rat skin.


Comparative distribution of  75 Se in the hard and soft tissues of mother rats and their pups.


Antiselenium activity of tri-o-cresyl phosphate in rats and Japanese quail.


Wax esters in fish: absorption and metabolism of oleyl alcohol in the gourami (Trichogaster cosby).


Food intake regulation: amino acid toxicity and changes in rat brain and plasma amino acids.


Effect of dietary vitamin E on the activities of the glutathione peroxidase system in rat tissues.


Metabolism and the electrical activity of anoxic ventricular muscle. 1. The action potential duration of anoxic guinea-pig ventricular muscle was related to ATP generated by glycolysis. In 50 mM glucose medium the action potential duration was maintained; in 5 mM glucose medium the action potential duration shortened, the glycolytic rate declined and the ATP content was reduced.2. The action potential amplitude was related to the metabolic state of the muscle but not to the intracellular sodium concentration.3. It is suggested that changes in the action potential duration and overshoot in anoxic muscle may be due to an influence of metabolism on the slow inward current.4. Anoxic muscle incubated for 8 hr in 5 mM glucose medium had an E(m) of -77.1 mV compared to -81.1 mV in fresh muscle. The calculated E(k) of anoxic muscle was -47.4 mV.5. The resting potential of anoxic muscle was separated into two components, one dependent on potassium distribution and the other on the activity of an electrogenic sodium pump.6. The electrogenic pump component was stimulated upon raising the glucose concentration of the medium or upon raising the external potassium concentration.7. The electrogenic pump component was inhibited by ouabain or by reduction of the temperature from 35 to 8 degrees C.


The effect of baroreceptors on the latency of evoked responses in sympathetic nerves during the cardiac cycle. 1. A rapid increase in pressure in a vascularly isolated perfused carotid sinus has been shown to inhibit a reflex response in efferent sympathetic nerves of the dog evoked by electrical stimulation of the radial nerve.2. In intact preparations with the carotid baroreceptors innervated, the mean latency and the variance of the latency of reflex sympathetic nerve responses was reduced when the stimuli evoking the responses were applied at one point of both cardiac and respiratory cycles. When the baroreceptors were denervated there were no significant differences in the responses to random and synchronized stimuli.3. In intact preparations the latency of evoked responses in sympathetic nerves was found to vary progressively during a cardiac cycle; the maximum increase in latency was observed with the responses that occurred at that phase of the cardiac cycle when the baroreceptors exert maximal inhibition on spontaneous sympathetic activity. After denervation of the carotid sinuses a much smaller change during the cardiac cycle was still present, possibly due to effects produced by baroreceptors of the aortic arch and elsewhere.4. It was concluded that changes in baroreceptor activity, due to beat to beat fluctuations of the systemic arterial pressure are a major factor causing variations in the latency of responses in sympathetic nerves evoked by stimuli applied to a cutaneous nerve.


Conductance changes, an electrogenic pump and the hyperpolarization of leech neurones following impulses. Following trains of impulses, sensory neurones in the C.N.S. of the leech show a prolonged hyperpolarization, which lasts for seconds or minutes. In the present investigation the mechanisms that underly this hyperpolarization have been studied by recording intracellularly. Two factors have been found to be responsible. One is the activity of an electrogenic pump (see Baylor & Nicholls, 1969b); the other is a long-lasting change in K conductance.1. Additional evidence that an electrogenic pump contributes to a slow after-hyperpolarization of leech sensory neurones is provided by the effects of injecting Na intracellularly. This leads to an increase in membrane potential that is blocked by the cardiac glycoside strophanthidin. Furthermore, after a train of impulses, reducing the K concentration in the external fluid characteristically reduces the hyperpolarizing action of the pump.2. The hyperpolarization following impulses is associated with a reduction of the cell membrane resistance that can persist for several minutes.3. Several lines of evidence suggest that the reduction in input resistance during the hyperpolarization is mainly due to an increased permeability to K. Thus, when the K concentration in Ringer fluid is reduced, the peak amplitude of the hyperpolarization following a train becomes larger. Furthermore, the conductance dependent part of the after-hyperpolarization has a reversal potential close to the equilibrium potential for K (E(K)). Substitution of Cl by SO(4) has little effect either on the after-hyperpolarization or on the conductance change following a train.4. Increased external Ca concentrations lead to a marked increase in the hyperpolarization that follows impulse activity. The enhanced hyperpolarization in high Ca is associated with a corresponding reduction in input resistance. The amplitude and duration of the hyperpolarization following a brief train of impulses can be increased by a factor of 5 or more in Ringer fluid containing 10 mM-Ca instead of the usual 1.8 mM. The hyperpolarization and resistance changes still occur in solutions containing 20 mM-Mg.5. To augment the hyperpolarization the increased concentration of Ca must be present during the train of impulses.6. The relative contributions of the K conductance increase and of the electrogenic pump for generating the hyperpolarization after impulse activity are different in the three types of sensory cell responding to touch, pressure and noxious stimulation.


The effect of increasing the innervation field sizes of nerves on their reflex response time in salamanders. 1. A simple quantitative measure was sought which could describe the relationship between reflex coupling in the spinal cord of salamanders and the peripheral innervation fields of the nerves from which the reflexes were elicited.2. In decerebrate salamanders reflex responses were recorded between pairs of cut hind limb nerves. The latencies (S/R times) of these reflex responses were bilaterally symmetrical for a given pair of nerves and were shorter when the stimulated nerve of the pair had a large motor and sensory peripheral limb innervation field; this was especially obvious for reflexes between 15th and 17th segmental nerves.3. After cutting or crushing the 16th nerve in adult salamanders, the adjacent 15th and 17th nerves sprouted collaterally to innervate denervated skin and muscle. There was apparently complete recovery of normal tactile reflexes and walking movements within a month.4. The operation did not affect the reflex response (S/R) times for nerve combinations on the unoperated side, which were not significantly different from those of normal animals with similar sized peripheral nerve fields. The unoperated side therefore represented the preoperative condition.5. In animals where one or both the 15th and 17th nerves had increased its innervation field size, the S/R times between them were significantly shorter on the operated side when the nerve with the enlarged field was stimulated. The degree of shortening was greatest for nerves showing the largest increase in peripheral field area.6. The S/R times between the 15th and 17th nerves were similar to those measured in normal animals in which the peripheral fields were of similar size to the enlarged fields in the operated animals. In a few cases where the increase in field size was considerable, the S/R time between the 15th and 17th nerves became as short as that between the 15th and 16th nerves on the control side.7. After removal of the 15th nerve, the 14th nerve sprouted into the trunk skin and muscle previously innervated by the 15th nerve and the 16th nerve into denervated limb skin and muscle. In spite of the increased peripheral fields of both these nerves, there was no change in the S/R times between them, or between any other pair of limb nerves on the operated side.8. The decrease in the S/R times between the 15th and 17th nerves was only observed where the stimulated nerve had increased its peripheral limb innervation field. The possible causes and significance of this shortening reflex response times are discussed in the context of an apparently functionally appropriate adaptation in the spinal cord.


The effect of adrenalectomy or pharmacological inhibition of adrenocortical function on macromolecule uptake by the new-born rat intestine. 1. Bilateral adrenalectomy in 18-day-old rats resulted in an extension by approximately 4 days of the period during which the villous epithelial cells of the small intestine took up polyvinyl pyrrolidone (PVP) of mean mol. wt. 160,000.2. The eventual termination of PVP uptake (;closure') closely resembled normal closure in control animals: the time course of the decline in uptake and the histological changes indicated that more mature ;PVP-impermeable' cells progressively ascended the villi.3. Injection of Metopirone was ineffective in animals 10 days after birth, but when injected after day 13 caused closure within 3 days.4. Metopirone injection significantly reduced the plasma concentration of corticosterone and caused a marked rise in the plasma concentration of deoxycorticosterone.5. Aminoglutethimide injection also produced precocious closure and had an effect similar to Metopirone on the plasma concentrations of corticosterone and deoxycorticosterone.6. Injection of Metopirone or aminoglutethimide increased the relative adrenal weight compared with control animals. Aminoglutethimide was more effective and caused approximately a 100% increase in adrenal weight.


The effect of amiloride on sodium and potassium fluxes in red cells. 1. The effect of amiloride on the influx and efflux of (24)Na and (42)K in red cells was studied. The drug was added to the bathing Ringer or else incorporated in resealed ghosts.2. Amiloride does not inhibit the active or the passive (ouabain insensitive) extrusion of (24)Na.3. Amiloride inhibits the influx of (24)Na into red cells by 70%.4. Whether added to the inside or to the outside of the cells amiloride has no effect on the efflux of (42)K.5. Amiloride does not modify the uptake of (42)K from control Ringer. This uptake is strongly inhibited by the removal of Na. Amiloride has no effect on the extent of this inhibition.6. It is concluded that amiloride specifically inhibits the passive penetration of Na, and has no effect on the Na-K-pumping mechanism. However, at the concentration which inhibits 70% of the influx, amiloride fails to produce an observable effect on the ouabain-insensitive Na-efflux.7. On the basis that the information obtained could be extrapolated to other membranes, the effect of amiloride on epithelial membranes is discussed.


The contrast sensitivity of the cat.

The contrast sensitivity of the cat. 1. The experiments were carried out on pretrigeminal cats.2. By recording potentials evoked from the visual cortex by a grating stimulus, it was established that there was a linear relation between the voltage generated and the logarithm of the contrast of the grating.3. The voltage evoked by the grating was independent of the orientation of the grating.4. It has previously been shown in man that, if the contrast is determined by an extrapolation to the point at which a zero voltage occurs, this value corresponds to the psychophysical threshold. On the assumption that the threshold of the cat also occurs at zero voltage, thresholds for a number of spatial frequencies and orientations were determined.5. When the threshold sensitivity function for the cat is compared with man it is found to be displaced to lower spatial frequencies by a factor of about ten. This means that while the cat cannot see such high spatial frequencies as man, it can see lower frequencies better than man.


Uptake of calcium and magnesium by rat duodenal mucosa analysed by means of competing metals. 1. The short-term uptake of Ca and Mg by rat duodenal mucosa consisted of two parts, one apparently complete within 1 min (uptake I) and a second which increased linearly with time from 1 to 12 min (uptake II).2. Uptake II for both Ca and Mg showed a curvilinear dependence on concentration. Uptake I was related linearly to concentration up to the highest concentration tested.3. Mg caused a significant inhibition of Ca uptake II. Ca was without effect on Mg uptake.4. Mn reduced significantly both uptakes I and II for Ca; Ba and Sr were without effect on Ca uptake.5. Two lanthanides, La and Pr, both inhibited uptakes I and II for Ca. Inhibition by Pr could be reversed by increasing the concentration of Ca. Some uptake II for Ca still persisted when uptake I was completely abolished by 3 mM-La.6. It is suggested that a small part of Ca uptake I may be associated with the subsequent mediated entry into the mucosa, since inhibition of Ca uptake consistently involves both forms of uptake. However, since some Ca still enters the mucosa when uptake I is completely inhibited, it appears that some entry of Ca can occur by diffusion.


Contour-like phosphenes from electrical stimulation of the human eye: some new observations. 1. The contour-like phosphenes that may be seen with electrical stimulation of the human eye are described.2. It is found that a moving edge is particularly effective in generating these patterns.3. The relation between the velocity of the edge, the frequency of the current and the resultant spatial frequency of the lines is as if one line were generated at the edge for every cycle of the current.4. The frequency-dependence of the phase-shift between phosphene and current is such as would be expected if the light was delayed by some 30 msec relative to the current at the site of interaction.5. Evidence is brought forward suggesting that this phenomenon is the result not of interference-like processes, but of coupling interactions of the retinal neurones, dividing the population into domains responding in opposite phase to the electrical stimulation.


Bacterial meningitis in infants.

Bacterial meningitis in infants.


Pulmonary function single breath testing. A one month study.


The Seed.

The Seed.


A drug induced koro syndrome.

A drug induced koro syndrome.


Life savers.

Life savers.


Selecting Blue Shield Board members.

Selecting Blue Shield Board members.


Micropuncture study in rats with experimental glomerulonephritis.


Effect of furosemide on free water excretion in edematous patients with hyponatremia.


Vasopressin-related alterations of sodium reabsorption in the loop of Henle.


Diagnosis of Barrett's esophagus by pertechnetate scintigraphy.


Echocardiographic diagnosis of right atrial myxoma.


Bartter's syndrome. An unusual presentation.


Academic medicine and American society: interdependent or independent?


Medical school teachers--there is a message from an airline.


Systems theory applied to medical education.


The decline in emphasis on basic medical sciences in medical school curricula.


CNS and fatty acid metabolism.

CNS and fatty acid metabolism.


Extra-amniotic prostaglandin-oxytocin abortion: comparison with the intra-amniotic method.


Serum PGF2alpha levels during human pregnancy. Guttierez Cernosek and his colleagues reported that the level of PGF2a in human serum reached a peak during the second trimester of pregnancy, the highest levels being found during the 17th-24th weeks.  Earlier studies in this laboratory on late pregnancy have now been extended to earlier gestations and rather than peak levels during the 17th-24th weeks, the lowest levels were found at this time.  A total of 128 samples from 106 women were studied.  The levels found during the second trimester were significantly lower than those found at earlier gestations.  However, the mean serum PGF2a level during the second trimester was not significantly different from the mean level during the third trimester.  The discrepancy between the 2 sets of results is very marked, so that there is obviously need for much further research in this sphere.


Aspirin and indomethacin: effect on instillation-abortion time of mid-trimester hypertonic saline induced abortion.


Effects of prostaglandins on the affinity of hemoglobin for oxygen in human whole blood in vitro.


Effect of prostaglandin F2alpha on anterior pituitary function in man.


Effects of a cholesterol esterase inhibitor and of prostaglandin F2alpha on testis cholesterol and on plasma testosterone in mice.


Steroid release from polymer vaginal devices. Effect on fertility inhibition.


Competitive protein binding assay of progesterone without chromatography.


Determination of estriol, estriol sulfate, progesterone and neutral steroid mono- and disulfates in umbilical cord blood plasma.


Complex formation by  3 H-aldosterone in rat kidney and liver.


Sex-dependence of the metabolism of aldosterone in adrenalectomized and intact rats.


Fluorimetric estimation of testosterone and epi-testosterone in urine and plasma.


Further studies on the temperature dependence of the binding of testosterone to human pregnancy plasma proteins.


The development of daily change in serum corticosterone in pre-weanling rats.


Biologic activity of 16 -methyldichlorisone-17-butyrate in the rat and dog.


Effects of histone on morphogenesis of chick embryonic constituents. I. The teratogenic range.


Is there a connection between maternal zinc deficiency and congenital malformations of the central nervous system in man?


It would be funny if it weren't so sad.

It would be funny if it weren't so sad.


A meiotic cytogenetic study in mice of a commonly used tranquilizer reported to concentrate in mammalian follicular fluid.


Lupin alkaloids from teratogenic and nonteratogenic lupins. I. Correlation of crooked calf disease incidence with alkaloid distribution determined by gas chromatography.


Lupin alkaloids from teratogenic and nonteratogenic lupins. II. Identification of the major alkaloids by tandem gas chromatography-mass spectrometry in plants producing crooked calf disease.


Inhibition of palatal fusion in vitro by  -2-thienylalanine.


Skullbase malformations in rat fetuses with hypervitaminosis A-induced exencephaly.


Congenital heart disease in dogs: epidemiologic similarities to man.


Techniques for prenatal neurosurgical operations on rat fetuses and for obtaining postnatal survivors.


Protective effect of deoxycytidylic acid (CdMP) on hydroxyurea-induced malformations in rats.


Alkaline phosphatase activity in fetal hind limbs of the mouse mutation brachypodism.


The surgical management of leprosy.

The surgical management of leprosy.


Mycetoma.

Mycetoma.


The vacuum extractor.

The vacuum extractor.


Precipitation of reactions in lepromatous leprosy by vaccinia.


Preventive immunization for babies born in the tropics.


Bilateral ureterocystoplasty with solely bladder tube flap. An experimental study in dogs.


Management of leprosy in the community.

Management of leprosy in the community.


Surgical correction of vesicoureteral reflux. Description of technique and results.


Microanatomy of the ventral cord ganglia of the horseshoe crab, Limulus polyphemus (L.).


Structural changes of drosopterinosomes (red pigment granules) during the erythrophore differentiation of the frog, Rana japonica, with reference to other pigment-containing organelles.


An improved method of isolation of crystalline basic trypsin inhibitor from bovine tissues.


Changes of ribosomal activity in rat kidney after unilateral nephrectomy.


Prolonged incubation of blood in an open system with bicarbonate buffer.


Direct synthesis of the 2'-O-methyl analogues of 1- -(D-arabinofuranosyl) cytosine and uracil and some related derivatives.


Ultraviolet and infrared spectral studies on the structure and tautomeric forms of 2-thiobarbituric acids and 2-thiobarbitals.


Systematic serum calcium screening--will it be necessary?


Serum phosphate and calcium and phosphate excretion at different levels of serum calcium in hyperparathyroidism.


Clinical findings in patients with hypercalcaemia. A preliminary investigation based on biochemical screening.


Hypercalcemia in adrenocortical insufficiency.


Loss of consciousness from arrhythmia: the patient's experience.


A-V nodal rhythm in acute myocardial infarction.


The significance of psychological events in a coronary care unit. Preliminary report.


Reproducibility of the ECG classification system of the Minnesota code in the study of patients with coronary heart disease.


Plasma concentration of digoxin in out-patients.


Immunoglobulins in pulmonary eosinophilosis (tropical eosinophilia).


Acquired haemolytic anaemia. II. Drug-induced haemolytic anaemia.


Myocardial metabolism of exogenous plasma triglycerides in resting man. Studies during alimentary lipaemia and intravenous infusion of a fat emulsion.


Acute myocardial infarction occurring during continuous ECG recording.


The earliest phase of acute myocardial infarction in man.


Cystic fibrosis (mucoviscidosis).

Cystic fibrosis (mucoviscidosis).


Preventing rheumatic fever and rheumatic heart disease.


Biologic half-life of drugs.

Biologic half-life of drugs.


Dietary prevention of atherosclerosis.

Dietary prevention of atherosclerosis.


Rapid death and extradural hematoma.

Rapid death and extradural hematoma.


The difficult patient in the general hospital.


Disc susceptibilities to four tetracyclines.


Effect of incubation time and anticoagulant on the activated partial thromboplastin time.


An automated o-toluidine glucose procedure without acetic acid.


Brain and spinal cord lesions in horses inoculated with Venezuelan equine encephalomyelitis virus (epidemic American and Trinidad strains).


Critical test evaluation of mebendazole against gastrointestinal parasites of horses and ponies.


Effects of sodium fluoride on dairy cattle: influence of nutritional state.


Packed cell volumes of cattle exposed to controlled cold environmental temperatures.


Certain metabolic responses of swine to epinephrine and norepinephrine infusion.


Evaluation of levamisole against experimental infections of Ascaridia, Heterakis, and Capillaria spp. in chickens.


Needle biopsy of skeletal muscle in dogs: light and electron microscopy of resting muscle.


Inflammatory response in dogs given intraarticular injection of Mycobacterium butyricum-mineral oil adjuvant.


Second lumbar spondylectomy and shortening of the spinal column of the dog.


Systematic treatment of ethylene glycol toxicosis in dogs.


Observations on thyroid gland function in dogs: response to thyrotropin and thyroidectomy and determination of thyroxine secretion rate.


Preparation of complement-fixing antigens from tissue of dogs infected with Neorickettsia helminthoeca.


Studies of Leptospira illini, strain 3055: pathogenicity for different animals.


Postnatal body weight changes of domestic cats maintained in an outdoor colony.


Blood glutathione in aging lambs.

Blood glutathione in aging lambs.


Nigropallidal encephalomalacia in horses in New South Wales.


Capillaria hepatica in a dog.

Capillaria hepatica in a dog.


Hookworms in cats and dogs in Queensland.


Survival of nematode larvae after freezing over liquid nitrogen.


A proliferative interstitial pneumonia of sheep associated with mycoplasma infection. 1. Natural history of the disease in a flock.


A proliferative interstitial pneumonia of sheep associated with mycoplasma infection. 2. The experimental exposure of young lambs to infection.


Dairy herd wastage in South Eastern Queensland.


Coumatetralyl poisoning in pigs and effectiveness of vitamin K1.


Quantitative measurement of microsomal subfractions isolated from livers of rats fed with 1,1,1-trichloro-2,2-bis (p-chlorophenyl ethane (DDT).


Metabolic studies of synthetic isojuripidine in the dog and rat.


Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites.


The intracellular localization of   9 -tetrahydrocannabinol in liver and its effects on drug metabolism in vitro.


A site of action of novobiocin in inhibiting renal tubular transport of drugs in the chicken.


Effect of protein depletion in guinea-pigs on glucuronate conjugation of chloramphenicol by liver microsomes.


Transport and binding of decamethonium in mouse kidney slices.


Effect of suramin (Bayer 205) on hepatic microsomal cytochromes P-450, b 5 , and demethylation activity in rats.


Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from sexually-immature male and female rats treated with phenobarbitone.


Hepatotoxicity of CS 2  in rats: relation to postexposure liver weight and pre-exposure cytochrome P-450 level.


Lymphocyte in vitro cytotoxicity: mechanism of human lymphotoxin-induced target cell destruction.


The induction of cellular immunity with soluble murine histocompatibility antigens.


Resistance of neonatal tolerance in mice to abrogation by normal immunocytes.


Uptake and reduction of radioactive folate by everted sacs of rat small intestine.


On the interaction of  -amylase with substrate and inhibitors, with comments on Koshland's induced-fit hypothesis.


Conditions affecting the dissociation reaction in vitro of rat-liver ribosomes.


Cellular cooperation in hapten-carrier responses in the newt, Triturus viridescens.


The interaction of bilirubin with human serum albumin.


Treatment of multiple independent ligand-binding equilibria with special reference to the circular dichroism of the bilirubin-human serum albumin system.


Structure and function of the genome of coliphage T5. 2. Regions of transcription of the chromosome.


The interactions of 2-thiopyrimidine bases with hydroxymercurybenzene sulfonate.


Open education for emotionally disturbed children.


Hydrolysis of ( 3 H,  14 C)phosphatidylethanolamines by acid phospholipases A of subcellular fractions of rat spleen.


Language comprehension in the moderately retarded children.


Auditory processing for the child with language disorders.


The special child in the regular classroom.


Direct and correlated responses to two-way selection for hindleg muscle system weight in mice.


Influence of levels of methionine and cystine on the total sulfur amino acid requirement of the growing rat.


Comparison of blood source and diurnal variation on blood hydrocortisone, growth hormone, lactate, glucose and electrolytes in swine.


Estrus, ovulation and conception in hormone treated prepuberal Hereford heifers.


A comparison of two methods for boar semen collection.


Estimated five component viscoelastic model parameters for human arterial walls.


Impact on a simple physical model of the head.


Regional myocardial dynamics from single-plane coronary cineangiograms.


Analysis of surface bone strain in the calcaneus of sheep during normal locomotion. Strain analysis of the calcaneus.


Response of joints to impact loading. 3. Relationship between trabecular microfractures and cartilage degeneration.


Bone remodeling and piezoelectricity. I.


Biomechanical analysis of knee flexion and extension.


The nature of the optimum muscular performance achieved in the execution of fast eye rotations.


An analysis of mechanical cardiac assistance.


The Second Marie Stopes Memorial Lecture. Female sexuality.


Biological aspects of a high socio-economic group. II. IQ components and social mobility.


Multiple influences on deviant behaviour in children with epilepsy.


Social and medical factors in the use and effectiveness of IUDs.


Family size and ordinal position: correlates of academic success.


A study of the relationship between attitudes towards world population growth and USA population growth.


Menopausal age and symptomatology in a general practice.


Incidence of breast nodules in women receiving multiple doses of medroxyprogesterone acetate.


A demographic and social study of fertility in rural New Guinea.


Synovectomy of the elbow in rheumatoid arthritis.


Double hemiarthroplasty of the knee in rheumatoid arthritis. A survey of fifty consecutive cases.


Treatment of the popliteal cyst in the rheumatoid knee.


Arthroplasty of the forefoot in rheumatoid arthritis.


Wound healing after operations of patients with rheumatoid arthritis.


The Ellis plate operation for Smith's fracture.


The nail-patella syndrome. A report of three families.


Resection osteosynthesis and Boyd amputation for congenital pseudarthrosis of the tibia.


Post-radiation sarcoma in ankylosing spondylitis. A report of five cases.


Ball and socket ankle joint in metatarsus adductus varus. (S-shaped or serpentine foot).


A review of excision of the trapezium for osteoarthritis of the trapezio-metacarpal joint after twenty-five years.


The extensor diversion graft operation for correction of intrinsic minus fingers in leprosy.


Surgical treatment for derangement of the lumbar spine.


Excision of the distal end of the ulna in rheumatoid arthritis.


Identification of crystals deposited in brain and kidney after xylitol administration by biochemical, histochemical, and electron diffraction methods. The positive identification of crystals of calcium oxalate occurring in brain and kidney after xylitol administration is described. Biochemical, histochemical, conventional light and electron microscopical methods, including selected area electron diffraction, were used to characterize the crystals.


The separation of epinephrine from norepinephrine and dopamine from DOPA on Sephadex G-10. Epinephrine and norepinephrine were separated by acid elution through a Sephadex G-10 column with high recovery (better than 90%), excellent reproducibility, and little overlap (less than 10%). Once packed, the columns could be re-used indefinitely. Total elution time was about six hours and the columns could be left untended since the gravity flow stops automatically once the level of the eluant reaches the gel bed. The resulting dilution was five-fold. 3,4-Dihydroxyphenylalanine (DOPA) was completely separated from 3,4-dihydroxyphenylethylamine (dopamine) by the same procedure.


Characteristics of the antitrypsin activity of human serum. The antitrypsin activity of human serum was studied as a function of pH, preincubation of serum with trypsin, and the concentrations of substrate, trypsin, and serum. Maximal activity was observed between pH 8.0 and 8.3. Activity was enhanced by preincubation of serum with trypsin, and reduced by high concentrations of trypsin and substrate. Percentage inhibition was a sigmoid function of log serum concentration. Theoretically, this relationship is expected of a reversible enzyme inhibitor; reversibility was demonstrated by dilution of enzyme serum mixtures. Practically, this relationship limits accurate antitryptic activity assay to the 25-75% inhibition range.


Comparison of two-point (AutoAnalyzer II) with kinetic methods for transaminase assay. The general performance of the Technicon AutoAnalyzer II method for the routine estimation of serum aspartate and alanine transaminase has been assessed and compared with that of the LKB reaction rate analyser. The results of the two methods correlate, there is little difference in precision, and running costs are comparable. Some of the relative advantages of the two types of analysis are discussed.


Comparison of two laboratory tests in the control of anticoagulant therapy. A prospective, randomized trial is described in which the usefulness of two tests in the control of anticoagulant therapy is compared. Fifty-two patients were controlled by the one-stage prothrombin time and 55 by the activated partial thromboplastin time. There was no significant difference in the incidence of bleeding between the two groups. When bleeding did occur, it was more often reflected by prolongation of the prothrombin time than of the activated partial thromboplastin time. The prothrombin time was found to have some practical advantages over the activated partial thromboplastin time.


Workshop No. I: the place of group practice, partnerships and assistants in the G.M.S.


Workshop No. 2: the remote and unattractive areas.


Workshop No. 3: ancillary services.

Workshop No. 3: ancillary services.


Workshop No. 5: practice organization.

Workshop No. 5: practice organization.


Workshop No. 6: towards more efficient use of the General Medical Service.


Workshop No. 4: the recruitment of students to medicine; training for general practice; continuing education.


New drugs. No. I. Beclomethasone aerosol.


Workshops on general practice.

Workshops on general practice.


Treatment of uncomplicated gonorrhoea in the female with single injection of 4.0 M.U. procaine penicillin fortified.


Regional cerebral blood flow in Thais. A measurement by intracarotid injection of  133 Xenon.


Trichotillomania: a case report.

Trichotillomania: a case report.


Incorporation of the entire medical staff of a municipal hospital: one solution to the academic problems of the 1970's.


Training foreign academicians in U.S. medical schools.


An elective clinical teaching program for first-year medical students.


Which skills should be taught in the surgical clerkship?


Experimental intestinal ischemia: provocative absorption studies following gradual celiac and superior mesenteric artery occlusion.


The effect of long-term steroid therapy on the histopathology of regional enteritis.


Preoperative preparation, operative technique, and postoperative care of patients undergoing jejunoileal bypass for massive exogenous obesity.


Effects of lumbar sympathectomy on skin capillary blood flow in arterial occlusive disease.


Microradiographic characterization of bronchoconstriction after pulmonary embolism.


Circulation in profound hypothermia.

Circulation in profound hypothermia.


Follicles in human parathyroid glands.

Follicles in human parathyroid glands.


The uptake and utilization of  3 H-uridine by young mouse cartilage cells studied autoradiographically.


Peroxidase uptake by renal papillary cells of normal and hypokalemic rats.


Preferential recovery of uniparental streptomycin resistant mutants from diploid Chlamydomonas reinhardtii.


Mechanism of cholestasis. VII.  -Naphthylisothiocyanate-induced jaundice.


Induction of Mendelian and non-Mendelian streptomycin resistant mutants during the synchronous cell cycle of Chlamydomonas reinhardtii.


Noninvasive regional myocardial perfusion with radioactive potassium. Study of patients at rest, with exercise and during angina pectoris.


Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency.


Infantile methemoglobinemia caused by carrot juice.


Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-1973.


Systemic heparinization for femoral percutaneous coronary arteriography.


Bach mai: spectrum of reactions.

Bach mai: spectrum of reactions.


The image of the heart.

The image of the heart.


Efficacy of rubella vaccines.

Efficacy of rubella vaccines.


Calcification of "floppy" mitral leaflets.


Nonepidemic features of heroin addiction.


Skeletal support in multiple myeloma.

Skeletal support in multiple myeloma.


Bingo for burns.

Bingo for burns.


Tracer methods to assess health.

Tracer methods to assess health.


Medical-scientific chauvinist pigism.

Medical-scientific chauvinist pigism.


Self-liberation for males.

Self-liberation for males.


Thrombocytopenia in malignant diphtheria.


Estimation of hydrogen ion concentration.


Plasticizers in human tissues.

Plasticizers in human tissues.


BCG vaccination in Massachusetts.

BCG vaccination in Massachusetts.


Levodopa and nail growth.

Levodopa and nail growth.


Drug interaction--propranolol and cafergot.


Metabolism of benzodiazepines.

Metabolism of benzodiazepines.


Distribution of dissolved mercury in the Irish sea.


In vitro morphine antagonism by antibodies.


Localization of paternal DNA in interphase nuclei of mouse eggs during early cleavage.


Evidence for an empty core in a bacterial flagellum.


Alpha rhythms and hyperkinesis.

Alpha rhythms and hyperkinesis.


UK 786 possible species-specific toxicant for Norway rats.


E.N.T. case of the month.

E.N.T. case of the month.


A clinical study of pulmonary embolic disease.


Fine structure of antennal sensilla coeloconica of culicine mosquitoes.


Studies on the tardigrades. I. Fine structure of the anterior foregut of Milnesium tardigradum Doyère.


Studies on the tardigrades. II. Fine structure of the pharynx of Milnesium tardigradum Doyère.


The fine structure of sense organs in the ovipositor of the parasitic wasp, Orgilus lepidus Muesebeck.


Tissue healing and septate desmosome formation in hydra.


The effects of cytochalasin D on differentiating muscle in culture.


Cytokinetic activities in a human cell line: the midbody and intercellular bridge.


Colchicine poisoning following ingestion of Gloriosa Superba tubers.


Tumoural calcinosis.

Tumoural calcinosis.


Gastric ulcer in tropical Africa. Clinical features and incidence in Burundi.


Non-filarial elephantiasis of the lower legs in Ethiopia. A simple method for rapid survey by school enquiry.


Distribution of intestinal helminths in children in the Yemen Arab Republic.


Epidemiologic-ecologic aspects of leptospira icterohaemorrhagiae carrier rodents in Israel seaports.


Paediatric survey at a district hospital in Uganda.


The urinary 'hydroxyproline index' in hospitalised and normal Malaysian children.


Serological studies of malaria in East Africa. II. Serological indices as parameters of progress of malaria control and eradication.


Cortical dimensions of second metacarpal in four ethnic groups of South African children.


Bladder involvement in schistosomiasis mansoni.


Indigenous Malay surgery.

Indigenous Malay surgery.


Epidemic of suicide by malathion poisoning in Guyana. Report of 264 cases.


The structure of L-mimosine, an L-DOPA analogue.


Incorporation of  3 H-leucine into insoluble proteins of neuronal and glial cell fractions in vitro.


MO-calculations on nitroxide radicals.

MO-calculations on nitroxide radicals.


Malignant giant-cell tumour of the colon.


Quantification of human seminiferous epithelium. IV. Histological studies in 17 men with numerical and structural autosomal aberrations.


Delayed hypersensitivity and high blood pressure in man.


Hypertrophic obstructive cardiomyopathy. A review of the patho-anatomic findings and the clinical characteristics including a report of two additional cases.


Enzyme histochemical studies of the lung of domestic fowl. The effects of unilateral pulmonary artery occlusion.


Effect of excessive vitamins C and E on vitamin A status.


Liver morphology and gallstone formation in hamsters and mice treated with chenodeoxycholic acid.


Effect of cessation of smoking on body weight after myocardial infarction.


Colony growth in primary cultures of Ehrlich ascites tumour using the agar method for human bone marrow culture.


Recognition and management of esophagitis, a pathophysiologic disease.


Surgical management of perforated diverticulitis of the colon.


Cecal necrosis and perforation with systemic chemotherapy.


Management of penetrating injuries of the neck.


Carcinoma developing in pilonidal sinus: Report of two cases and review of the literature.


Traumatic intrahepatic fistula of the hepatic artery and portal vein.


Bleeding duodenal ulcer in elderly patients.


Abdominal aortic dissection following nonpenetrating abdominal trauma.


Life-threatening arrhythmias in subarachnoid hemorrhage.


Aneurysm of anomalous right subclavian artery: Report of a case.


Replantation of amputated extremities. The necessity for re-evaluation.


An effective treatment of hypercholesterolaemia using a combination of Secholex and clofibrate.


The atrial complex in right atrial electrocardiography (RA ECG).


Determinants of coronary flow pattern.

Determinants of coronary flow pattern.


Intravascular catheter rupture.

Intravascular catheter rupture.


Quality of diagnostic examinations in a university hospital outpatient clinic.


Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans.


The "butterfly" sign in patients with chronic jaundice and pruritus.


Hyperamylasemia with carcinoma of the lung.


Hypouricemia due to renal uricosuria. A case study.


Cauda equina lesion associated with rheumatoid spondylitis.


Medical intensive care in the teaching hospital: costs versus benefits. The need for assessment.


Enduring attributes of medicine relevant for the education of the physician.


The doctor-patient relationship revisited. An analysis of the placebo effect.


Cell movement and host defenses.

Cell movement and host defenses.


The drug spotlight program.

The drug spotlight program.


Thoracic outlet syndrome, supraclavicular adenopathy, Hodgkin's disease.


Late occurrence of subacute bacterial endocarditis with closed atrial septal defect.


Alternation in jugular pulse.

Alternation in jugular pulse.


Risk in sickle-cell trait.

Risk in sickle-cell trait.


Anaphylactoid purpura, cold exposure, and cryofibrinogenemia.


Ethnic identification.

Ethnic identification.


Matching program for manuscripts.

Matching program for manuscripts.


Drug-induced pulmonary disease.

Drug-induced pulmonary disease.


Right bundle-branch block and prognosis.


ECG-monitor artifacts.

ECG-monitor artifacts.


Berlin Wall and sudden death.

Berlin Wall and sudden death.


Temporal arteritis, polymyalgia rheumatica.


Rubella reinfection.

Rubella reinfection.


Spinal fluid in coccidioidal meningitis.


Decreased incidence of post-appendectomy wound abscesses due to local application of ampicillin.


Chronic recurrent parotitis in children.


A rather rare complication of pulmonary arteriovenous fistula.


Crohn's disease of the regio gastroduodenalis.


Recurrent fibrosarcoma of the skin preceded by inflammation.


Partial resection of the ischium for tuberculous osteitis.


Cutaneous basosquamous carcinoma. Review of the literature and report of 35 cases.


How early in pregnancy does the Arias-Stella reaction occur?


Testicular microlithiasis.

Testicular microlithiasis.


Hyperplasia of pacchionian granulations.


Population dynamics of arterial smooth-muscle cells. II. In vivo inhibition of entry into mitosis of swine arterial smooth-muscle cells by aortic tissue extracts.


Myocardial component in fibroelastosis scar.


Extraskeletal mesenchymal chondrosarcoma.


Aneurysm of vein of Galen and diffuse meningeal angiectasia. Occurrence in a neonate with cardiac failure.


Human tumor microsporidiosis. First reported case.


Black-pigmented adenoma of the adrenal gland. Report of three cases including electron microscopic study.


Fetal thymic transplant in patients with Hodgkin's disease.


The effect of sodium cyanate on globin synthesis.


The sickle-unsickle cycle: a cause of cell fragmentation leading to permanently deformed cells.


Recessive familial erythrocytosis: aspects of marrow regulation in two families.


Membrane-mediated synthesis of tissue factor (thromboplastin) in cultured fibroblasts.


Glucosephosphate isomerase deficiency: evidence for in vivo instability of an enzyme variant with hemolysis.


Studies on regeneration of heterotopic splenic autotransplants.


Chronic plasma cell balanitis of Zoon. Report of two cases.


Gonococcal arthritis--a common rarity.

Gonococcal arthritis--a common rarity.


Cardiovascular effects of prostaglandin E 1  in experimental myocardial infarction.


Cardiovascular function and survival during severe systemic hypoxaemia: influence of glucose-potassium-insulin solution and of beta-blockade.


Myocardial ischaemia and cardiopulmonary bypass.


Autoradiographic evaluation of myocardial collateral circulation in the canine heart.


Coronary and systemic haemodynamic effects of prostaglandins in the unanaesthetized dog.


Conserving effect of thyroid hormone on myocardial ATP stores in vitro.


Estimation of the conduction time of the baroreceptor-cardiac reflex in man.


Heat clearance and heat production studies in acute experimental coronary occlusion.


Protein synthesis in fresh aortic and pulmonary value allografts as an additional test for viability.


Right and left heart pressures in acute myocardial infarction.


Mechanical properties of the ascending thoracic aorta of man.


Myocardial contraction velocity and acceleration in man measured by ultrasound echocardiography differentiation.


Indirect measurement of systolic blood pressure in the lower limb using a mercury in rubber strain gauge.


Myocardial contraction velocity measured by ultrasound echocardiography-differentiation and evaluated by left ventricular pressures in pigs.


Photodermatitis induced by chlorpropamide. A report of five cases.


Agranulocytosis during dapsone administration.


Lichenoid sarcoidosis with myocardial involvement.


Vitamin E and epidermolysis bullosa.

Vitamin E and epidermolysis bullosa.


Pemphigus vulgaris and pemphigus erythematosus.


Paradox temperature response in atopic dermatitis.


Some reactions of insulin at non-polar surfaces.


Dissociation of single ribosomes as a preliminary step for their participation in protein synthesis.


Inhibition on the reducing side of photosystem II by carbonylcyanide m-chlorophenylhydrazone and lithium 3,5-diiodosalicylate.


A numerical method for acquisition and processing of steady-state kinetic data contained in an entire progression curve. Application to the study of  -chymotrypsin-catalyzed hydrolysis.


The bacterial degradation of 5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone.


Problems connected with the repair of nerve sections.


The intratendinous architecture of the tendons of flexor digitorum profundus and flexor pollicis longus.


The hand in leprosy.

The hand in leprosy.


Flexor fibre protrusion through the digital fibrous flexor sheath.


Unstable fractures of the metacarpals. A method of treatment by transverse wire fixation to intact metacarpals.


Fracture of the fifth metacarpal resembling Bennett's fracture.


Multiple dislocations of a single finger.


Injuries to the collateral ligaments of the proximal interphalangeal joints.


Transarticular digital joint amputations: preservation of the articular cartilage.


Treatment of ganglia of the hand and wrist with aspiration and injection of hydrocortisone.


Carpal tunnel decompression and Dupuytren's Contracture. (Preliminary report).


Hamartoma in the hand--a simulator.

Hamartoma in the hand--a simulator.


A synoviotome--a new instrument for digital synovectomy.


The use of silicone rubber spacers in flexor tendon surgery.


Recent advances in the management of joint disease in the rheumatoid hand.


A comparison of two simple methods for determining pulmonary residual volume.


Exercise tolerance and body composition of male and female Africans aged 18-30 years.


A parameterization for individual human growth curves.


Weight growth in infancy. A regression analysis.


Visual excitation.

Visual excitation.


Comparison of congenital disc blurring and incipient papilledema in red-free light--a photographic study.


Full-thickness eye wall resection: evaluation of preoperative photocoagulation.


Electron microscopic study of the development of retinal Müllerian cells.


Erythema elevatum diutinum.

Erythema elevatum diutinum.


Syphilis control in Texas: a correlate.

Syphilis control in Texas: a correlate.


The persistence of elevated blood pressure first observed at age five.


Hypochromia of the rabbit iris induced by 6-hydroxydopamine.


Myocardial infarction over a five-year period. I. Prevalence, incidence and mortality experience.


The histoid variety of lepromatous leprosy.


Self-assessment mini-programs. Diagnosis of histoplasmosis of the tongue.


Some sources of variance in "accurate empathy" ratings.


Serum lipids and their relation to blood glucose and cardiovascular measurements in a rural population of Jamaican adults.


A relatively benign reticulosis: Crosti's "reticulohistiocytoma of the back".


Effects of touch on self-exploration and the therapeutic relationship.


Mortality among orchard workers exposed to lead arsenate spray: a cohort study.


Marijuana usage and hypnotic susceptibility.


Topical steroids--which one?

Topical steroids--which one?


Use of an analysis of variance technique for investigating the differential diagnosis of organic versus functional involvement of symptoms.


Internal-external control and social-political activism: a test of the dimensionality of Rotter's Internal-External scale.


Value of twin studies in dermatological genetics.


Ego defenses and reaction to stress: a validation study of the Defense Mechanisms Inventory.


Affective reactions toward computer-based intelligence testing.


Defensive and supportive communications in normal and deviant families.


Credibility and desirability of positive and negative structured feedback in groups.


Intradimensional reversal shift performance in brain-damaged and chronic alcoholic patients.


Trait-state anxiety and adjustment to surgery.


Client attributes and the eye of the beholder.


Effect of modeling and model status on verbal behavior in an interview.


Methodological problems and progress in schizophrenia research: a survey.


Effects of bombardment on the manifest anxiety level of children living in kibbutzim.


Concept of social skill with special reference to the behavior of depressed persons.


The future of clinical psychology.

The future of clinical psychology.


Aggression in thought and action of emotionally disturbed boys.


An analysis of three types of prognostic variables and treatment outcome.


Social desirability and adjustment in the Rotter Incomplete Sentences Blank.


Delay of gratification and internal locus of control in children.


Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients.


Values and attitudes: comparisons between staff and patients at a state hospital.


Laboratory experience with a magnetically guided intravascular catheter system.


Effect of skull rotation on X-ray evidence of displaced midline structures.


Anastomotic connections between the eleventh nerve and the posterior root of the first cervical nerve in humans.


Surgical treatment of brain abscess and subdural empyema.


Posterior orbital encephalocele with anophthalmos and other brain malformations. Case report.


Delayed traumatic myelopathy following transfixion of the spinal cord by a knife blade. Case report.


Dislocated lumbar vertebral epiphysis in adolescent children. Report of three cases.


Communication of hydromyelic cavity with fourth ventricle shown by combined Pantopaque and air myelography. Case report.


Saggital sinus repair. Technical note.

Saggital sinus repair. Technical note.


Ventriculofiberscope: a new technique for endoscopic diagnosis and operation. Technical note.


Elucidation of structure and stereochemistry of myriocin. A novel antifungal antibiotic.


Intramolecular catalysis. VI. Selectivity in 7 ,12 -dihydroxy steroids and enhancement of 12 -hydroxyl reactivity by substituents at carbon 3.


Inversions of both adjacent centers in the formolysis of a 2,2,6-trialkylcyclohexyl tosylate. Formation of a 13 -D-homo steroid.


Transformations of steroidal neopentyl systems. VII. Mechanism of the transformation of (19R)-hydroxy-19a-methyl-(5 )-3-ones to 19-keto-19a-methyl-(5 )-3 -hydroxy analogs.


Introduction of a 2',3' double bond into 1-(5'-O-benzoyl- -D-lyxofuranosyl)uracil by selective elimination reactions. A facile synthesis of 5'-O-benzoyl-3'-deoxy-2'-ketouridine.


The use of papain in resolving racemic N-(alkoxycarbonyl)glycines and N-(alkoxycarbonyl)alanines that contain small alkoxy groups.


Purine N-oxides. XLVI. Some interesting reactions of 3-acetoxy-8-methylxanthine.


Intramolecular and divalent metal ion catalysis. The hydrolytic mechanism of O-phenyl N-(glycyl)phosphoramidate.


Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata.


A synthesis of homoserine phosphate and a blocked derivative suitable for peptide synthesis.


Determination of C-22 epimers in steroids using nuclear magnetic resonance spectroscopy.


Functionalization of penicillins at carbon 6 via N-acylimines. 6-Hydroxypenicillin. Substituted penicillins and cephalosporins. 8.


Estimation of entropy of a binary variable: satisfying a reliability criterion.


A model of associative memory in the brain.


The fundamental mechanism of motion detection in the insect visual system.


Development and application of white-noise modeling techniques for studies of insect visual nervous system.


Some remarks on the tensorial linearization of general and linearly separable boolean functions.


A simplified sliding-filament muscle model for simulation purposes.


The individual, society and drugs.

The individual, society and drugs.


Psychotropic drugs in the world today.

Psychotropic drugs in the world today.


A home for retired physicians.

A home for retired physicians.


Cholestatic jaundice of pregnancy.

Cholestatic jaundice of pregnancy.


Optimal zone of methicillin activity for Staphylococcus epidermidis and its antagonism by other penicillins and cephalosporins.


Ocular hazards of squash.

Ocular hazards of squash.


Jaundice during pregnancy.

Jaundice during pregnancy.


Phenylketonuria testing in Australia. Sex ratio.


Fracture of the orbital floor. Case report with serious delayed sequelae.


The inner city--a special problem for community health.


Student evaluation of the Sydney university medical course.


Race, intelligence and education.

Race, intelligence and education.


In-vitro comparison of two barbiturate tablets in relation to possible absorption rates.


Chlorinated hydrocarbon pesticides in human blood and fat.


Estolate and stearate forms of erythromycin in beta-haemolytic streptococcal pharyngitis.


Rheology of blood: effect of dilution with various dextrans.


Effects of hemorrhagic shock on the microvasculature of skeletal muscle.


Effects of "smoking" doses of nicotine on RBC velocity in mesenteric capillaries.


Ultrastructural basis of the mechanism of rouleaux formation.


The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi.


The presence of large effective colloidal osmotic pressures across large pores.


Maximal substrate transport in capillary networks.


A modified colloidal osmotic transducer for the determination of transcapillary fluid movement.


Special purpose intravital microscope.

Special purpose intravital microscope.


Tracing of RNA from a puff in the polytene chromosomes to the cytoplasm in Chironomus tentans salivary gland cells.


Morphogenesis and regulation in spite of continued mitotic inhibition in Xenopus embryos.


A factor preventing the development of lung metastases in rats with sarcomas.


Preparation of tritium-labelled talc.

Preparation of tritium-labelled talc.


Physicochemical aspects of the action of general anaesthetics.


A unique RNA species from maturing mouse spermatozoa.


Long-term interactions of marijuana and behaviour in chimpanzees.


Human lymphocyte antigen association in ankylosing spondylitis.


High affinity transport of 2-deoxyglucose in isolated synaptic nerve endings.


T-mycoplasmas as a possible cause for reproductive failure.


Elevated arterial blood pressure in an asymptotic population of meadow voles (Microtus pennsylvanicus).


Carbon-13 nuclear magnetic resonance spectroscopy.


Multiphasic retention deficits at periodic intervals after passive-avoidance learning. Aftetr one-trial passive-avoidance training, indepelenet groups of rats tested promptly after training or at successive 6-hour intervals displayed a repetitive pattern of high then low retention scores. These results suggest that some physiological rhythm may interact with retention performance.


Unilateral cortical activity in newborn humans: an early index of cerebral dominance? Spectral analyses show unilateral photic driving in newborn human infants to bilateral repetitive visual stimulation. Results are interpreted as evidence of dominance in the right hemisphere for rhythmic visual stimuli and lack of interhemispheric integration.


Visual temporal order: a new illusion.

Visual temporal order: a new illusion. Brief visutal stimuli presented in rapid sequience, one to the left and one to the right, appear to occur left first, then right, regardless of the actual order of presentation. This illutsion persists under conditions of forced-choice testing and does not vary with presemitation to the same or opposite retinal hemifields, A series of experiments suggests that this illutsion may be the product of an internal mechanism that scans visual inputs in a left-to-right order.


Tobacco and evoked potential.

Tobacco and evoked potential. Significant changes were found in two indices of the averaged visual evoked potentials in nine smokers after 12 and 36 hours of abstinence and after resumption of smoking. There was a decrease of the amplitude envelope accompanying withdrawal and an increase with resumption of smoking. These changes are consistent with the contention that tobacco increases arousal. Amplitude changes were found in a specific component of the evoked potential occurring between 100 and 125 milliseconds after the onset of the flash. The latter changes suggest the possibility that smoking selectively enhances the perceptiont of weak stimuli.


Irradiated food.

Irradiated food.


How to help the patient who is dying.

How to help the patient who is dying.


Some common orthopedic problems of children.


Opiate antagonists and 'blockers'.

Opiate antagonists and 'blockers'.


The Drug Spotlight Program.

The Drug Spotlight Program.


Preventing diabetes.

Preventing diabetes.


Occlusive cerebrovascular disease.

Occlusive cerebrovascular disease.


Chronic obstructive lung disease.

Chronic obstructive lung disease.


How to treat arterial hypertension.

How to treat arterial hypertension.


Byssochlamyopeptidase A, a rennin-like enzyme produced by Byssochlamys fulva. The production of a rennin-like enzyme by Byssochlamys fulva varied considerably with the isolates tested. Among the seven isolates tested, NRRL 2260, IMI 83277, and N.Y. 1 were good enzyme producers. The enzyme produced by isolate IMI 83277 was purified approximately 20-fold after (NH(4))(2)SO(4) precipitation, diethylaminoethyl-cellulose chromatography and Sephadex G-100 gel filtration. The partially purified enzyme has a pH optimum at 2.9 and a temperature optimum around 60 C. The enzyme appeared to be relatively stable at 40 C between pH 3.0 and pH 6.85. A name, byssochlamyopeptidase A, was proposed for this new enzyme. The milk-clotting activity of byssochlamyo-peptidase A is dependent on pH and appeared to be minimal at pH 6.2 or above. No extensive proteolysis has been observed during the milk-clotting process. The non-trichloroacetic acid-precipitable nitrogen titration curve on skim milk was comparable to that catalyzed by animal rennet.


Volatile compounds produced in sterile fish muscle (Sebastes melanops) by Pseudomonas perolens. Volatile compounds produced by Pseudomonas perolens ATCC 10757 in sterile fish muscle (Sebastes melanops) were identified by combined gas-liquid chromatography and mass spectrometry. Compounds positively identified included methyl mercaptan, dimethyl disulfide, dimethyl trisulfide, 3-methyl-1-butanol, butanone, and 2-methoxy-3-isopropylpyrazine. Compounds tentatively identified included 1-penten-3-ol and 2-methoxy-3-sec-butylpyrazine. The substituted pyrazine derivative 2-methoxy-3-isopropylpyrazine was primarily responsible for the musty, potato-like odor produced by P. perolens.


Halophilic bacteria susceptibility to peracetic acid vapor and ethylene oxide. Extremely to slightly halophilic bacteria were tested for susceptibility to two sterilizing agents, peracetic acid (PAA) and ethylene oxide (ETO). PAA susceptibility was explored by two methods: an agar plate (constant pH of 7.2) and a filter strip (constant incubation period of 37 days); 100% susceptibility was obtained by both methods. The dosage (0.5 ml/min) was applied to a filter pad in a petri dish cover. Glove box experiments with ETO (input 1.5 lb. [ca. 680.4 g]/24 hr, the only constant) yielded 100% susceptibility for all halophiles tested. These experiments demonstrated the efficacy of two lethal agents for extreme halophiles, PAA and ETO. Variation in pH did not affect susceptibility.


Salmonella serotypes encountered at the South Dakota animal diagnostic laboratory. This paper summarizes the various Salmonella serotypes isolated from feed samples and cases of salmonellosis in domestic animals between 1 January 1970 and 1 June 1972.


Formalin-inactivated Venezuelan equine encephalomyelitis (Trinidad strain) vaccine produced in rolling-bottle cultures of chicken embryo cells. Formalin-inactivated Venezuelan equine encephalomyelitis vaccine was prepared from virus grown in rolling-bottle cultures of chicken embryo cells. Trinidad strain virus was propagated in these cultures with a maintenance medium consisting of serum-free medium 199 containing 0.25% human serum albumin (USP) and antibiotics. Manipulation of multiplicity of inoculum (0.06 to 0.00006) and maintenance medium volume (100 to 300 ml) resulted in high-titered virus yields and only moderate cell destruction when fluids from infected cultures were harvested at 18 to 24 hr. The virus was inactivated at 37 C by 0.05% Formalin within 8 to 10 hr and with 0.1% Formalin within 6 to 8 hr. Single dose, antigen extinction tests in mice performed with 30 small-scale vaccine lots showed excellent potency at either Formalin concentration with inactivation periods ranging from 24 to 96 hr.


Bacterial cleavage of an arylglycerol- -aryl ether bond. The first known cleavage by a bacterium of an arylglycerol-beta-aryl ether linkage, the most common intermonomer linkage in lignin, is described.


Effect of isopropanol on CCl 4 -induced changes in perfused rat liver hemodynamics.


Pharmacologic studies with 4,5-dihydro-1,3-dimethyl-1H-pyrazolo-(3,4-b) (1,4)-benzoxazepine hydrochloride.


Ontogeny of stereotyped behaviour induced by apomorphine and amphetamine in the rat.


The disposition kinetics of amphetamine in the ruminant animal.


Studies on the hypocalcemic action of 2-pyrrolecarboxylic acid.


The effects of amphetamine and cocaine on the response of the isolated guinea-pig vas deferens to noradrenaline, tyramine and nerve stimulation.


Effects of guanethidine on the isolated perfused spleen of the dog.


The effects of parenteral administration of catecholamines, serotonin and histamine on behavior and levels of these amines in the brain of the neonate chick.


Daunorubicin biliary excretion and metabolism in the rat.


Studies on the central nervous system effects of agroclavine, an ergot alkaloid.


Effects of anorectic agents on blood pressure of the dog.


Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.


Effect of phencyclidine on the accumulation of  14 C-catecholamines formed from  14 C-tyrosine.


Drug metabolism in the human fetal liver. Relationship to fetal age.


Attempts to induce drug metabolism in human fetal liver and placenta by the administration of phenobarbital to mothers.


Action of glucagon on electrolyte changes in the stomach, kidney and blood of dogs stimulated by pentagastrin or histamine.


Lack of antihypertensive effects of chronic administration of DL-propranolol in Grollman rats.


Effects of dimethylphenylpiperazinium (DMPP) on the coronary circulation in the dog.


A comparative description of inotropic agents in vitro.


Effect of trichloroethanol and of chloral hydrate on the in vivo rate of disappearance of ethanol in mice.


Reactivity to biogenic amines of isolated vasa deferentia and of ilea from guinea-pigs after repeated treatment with nicotine.


Direct and systemic effects of hexobendine on renal function.


Thresholds of sensitivity in metal contact allergy. 1. Isolated and simultaneous allergy to chromium, cobalt, mercury and-or nickel.


Growth of syngeneic tumours in unimmunized newborn and adult hosts. The post-natal development of "natural" resistance of Balb/c mice to the challenge of syngeneic tumours was studied using injections of various doses of live neoplastic cells into untreated animals of increasing age, from neonatal to 12 weeks.The minimum quantity of neoplastic cells capable of inducing tumours increased in parallel with the age of the animals. Immunodepression with whole body irradiation with X-rays reduced the resistance offered by adult mice to tumour challenge to that of the neonate. The relationship of the increase in resistance to tumour challenge with the development of the animals' own immune response during the course of post-natal growth is discussed.


Macrocolony assays in the rat of allogeneic Y-P388 and W-256 tumour cells injected intravenously: dependence of colony forming efficiency on age of host and immunity. Two rapidly growing allogeneic tumours, sublines of Yoshida (Y-P388) and Walker (W-256) injected intravenously in single cell suspensions produced tumour macrocolonies in the lungs of rats within 7 days. Y-P388 produced similar but fewer colonies in the kidneys. Colony forming efficiency (CFE) in lung was high in weanling rats given either sublethal whole body irradiation (WBI) or a single dose of rabbit anti-rat lymphocytic serum (ALS) to suppress immunity. In immunologically intact weanlings CFE was much lower and many 7-day old colonies showed signs of regression. CFE for primary tumour cell challenges decreased rapidly and markedly with increase in age of host during the first 1-2 weeks after weaning. This resistance to growth of a primary challenge in lungs of older rats was not significantly reduced by WBI but was decreased by ALS. CFE of a secondary challenge of tumour cells injected intravenously in rats which had been previously immunized with heavily irradiated (HR) tumour cells was very low; it was not significantly increased by WBI but was moderately increased by ALS. In weanling rats given lethal (900 rad) WBI, 1 hour before intravenous injection of tumour cells, treatment with bone marrow (BM) cells derived from normal adult donors increased CFE, whereas BM (or spleen) cells from immunized donors decreased CFE. The results suggest that ALS and WBI not only increase tumour CFE by suppressing immunity to tumour growth but also "condition" host tissue (tumour bed) in such a way as to facilitate the survival, "take" and initial replication of grafted tumour cells before the rats recover from the immunosuppressive effects of these treatments.


Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities. The reaction of the hepatocarcinogen N,N-dimethylnitrosamine has been compared with that of methyl methanesulphonate, a methylating agent which is not a liver carcinogen. Consistent differences have been observed in the reaction of rat liver DNA in vivo with these agents; O(6)-alkylation and the production of unidentified acid-labile products were distinctive features of the reaction with the carcinogenic nitroso compound but were undetectable or in low yield, respectively, after reaction with the alkyl sulphonate. Evidence has been obtained for the excision of these reaction products in animals treated with the hepatocarcinogen and the significance of their relative stabilities is discussed.


Environmental factors and cancer of the colon and breast. The correlation between cancer of the breast, colon and stomach dietary factors, and various indicators of standard of living was examined. Cancer of the breast and colon was highly correlated with fat and animal protein.


Enhanced malignant behaviour of cells treated with crude rat liver histone. Neonatal hamster kidney cells (BHK21/C13), challenged in monolayer culture for three days with crude rat liver histone, have been shown to exhibit increased malignant characteristics when injected subcutaneously into hamsters. In contrast to the controls, the challenged cells produced tumours which invaded either the epidermis or the body wall of their hosts and frequently caused extensive visceral metastases. In vitro studies of the cell cultures, during and after histone treatment, suggested that cellular "transformation" rather than selection was effected by the crude histone preparation. Cells from the primary tumours of both control and test groups appeared morphologically identical but after sub-culture in vitro they retained their respective growth characteristics on reinoculation.


Acquired retraction syndrome after sixth nerve palsy.


Injection site tumours and preceding pathological changes in rats treated subcutaneously with surfactants and carcinogens. The sequential histological changes and neoplastic response occurring in the subcutaneous tissue of rats after injection of surfactants or carcinogens were compared. Twice weekly subcutaneous injections of the surfactants Blue VRS and Light Green SF elicited a deranged connective tissue repair with continued proliferation of fibroblasts and extensive collagen desposition. In contrast, the carcinogens N-methyl-N-nitrosourea (MNU) and N-nitroquinoline-N-oxide (NQO) appeared to inhibit connective tissue repair and produce morphologically abnormal fibroblasts. The spectrum of neoplastic response was also found to differ. Surfactants gave rise to local sarcomata only after about 47 weeks, whereas carcinogens produced local sarcomata and adenocarcinomata after 20 and 12 weeks respectively.


Pre-school vision study.

Pre-school vision study.


Capsular exfoliation syndrome.

Capsular exfoliation syndrome.


Gas in the orbit associated with orbital cellulitis and paranasal sinusitis.


Treatment of proliferative diabetic retinopathy by repeated light coagulation. A 7-year review.


Senile choroidal sclerosis.

Senile choroidal sclerosis.


Reattachment of severed limbs.

Reattachment of severed limbs.


Unusual chorioretinal degeneration in sickle cell disease. Possible sequelae of posterior ciliary vessel occlusion.


Obesity and coronary heart disease.

Obesity and coronary heart disease.


Antibiotic levels in tissue fluid.

Antibiotic levels in tissue fluid.


Strikes by hospital ancillaries.

Strikes by hospital ancillaries.


New index for evaluation of oral glucose tolerance test results. A simple numerical index is presented which describes the shape of an oral glucose tolerance response curve and appears to be a measure of the efficiency of homeostatic control. It is unaffected by the laboratory method of glucose estimation, the site of blood sampling, the amount of glucose given, and whether or not the patient has fasted overnight. The index satisfactorily differentiates clinically diabetic from non-diabetic individuals and seems to provide a sensitive method of describing small changes in glucose homeostatic control such as might occur, for example, in pregnancy.


Concentration of antibacterial agents in interstitial tissue fluid. The concentration of antibacterial agents in the interstitial tissue fluid has been studied in an experimental model using implanted perforated Silastic capsules (tissue cages). Tissue fluid concentrations were always lower than the initial peak concentration in the serum, but for those drugs that were more slowly excreted the tissue fluid was similar to the serum concentration after six hours. In contrast the concentration in the tissue fluid for those drugs that are excreted rapidly was unpredictable, being either negligible or maintained at concentrations significantly better than in the serum. There was no evidence of accumulation in tissue fluid with regular dosage. These results indicate that the tissues may never be exposed to an adequate concentration of some antibacterial agents. This may be of clinical importance in tissue infections. Antibiotics which are rapidly excreted should be given in large enough doses and often enough for adequate blood levels to be maintained, so allowing equilibrium with tissue fluid to be achieved.


Effect of carbohydrate restriction in obese diabetics: relationship of control to weight loss. Two hundred newly diagnosed, fat diabetics were studied to determine whether control of the diabetes depended on loss of weight or on carbohydrate restriction alone. Satisfactory control was achieved by dietary treatment alone in 159 patients 30 required oral hypoglycaemic drugs and 11 were 18 of whom had actually gained weight. Of the remaining patients, 30 required oral hypoglycaemic drugs and 11 were still uncontrolled but not yet on other treatment.The mean initial excess weight of all 200 patients was 28%. Of those who remained uncontrolled on diet alone the mean initial excess weight (31%) was slightly but not significantly greater than that of those who were controlled (27%). Patients who were controlled lost slightly more weight than patients who were not, but their excess weight at the time of control was still 21%.We conclude that in 80% of obese diabetics control can be achieved by diet alone and that it is usually independent of weight loss.


Modification of plasma corticosteroid concentrations during and after surgery by epidural blockade. The adrenocortical response to major surgery was assessed by the measurement of plasma corticosteroid concentrations in patients receiving either a general anaesthetic alone or in combination with an epidural block. The expected increase in plasma corticosteroid concentration seen in the general anaesthesia group was significantly inhibited by epidural block. The inhibition was related to the duration of the epidural block. The lack of the normal adrenocortical response to surgery was not associated with cardiovascular collapse and indeed did not seem detrimental in any way. These findings question the need for corticosteroid "cover" for the stress of surgery in patients who have been taking corticosteroid drugs.


Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. The rate of paracetamol absorption depends on the rate of gastric emptying. Propantheline delayed gastric emptying and markedly slowed the absorption of paracetamol in six convalescent hospital patients. Conversely, the absorption of paracetamol in five healthy volunteers was accelerated by metoclopramide, a drug which stimulates gastric emptying. The total 24-hour urinary excretion of paracetamol was not influenced by propantheline or metoclopramide. Other similar absorption interactions probably occur since drugs are poorly absorbed from the stomach and many therapeutic agents influence gastrointestinal motility.


Treatment of chondromalacia patellae by transposition of the tibial tubercle. The first 20 patients treated by transposition of the tibial tubercle for chondromalacia of the patella are reported. The patients, usually adolescent girls, had failed to respond to conservative measures. Seventeen patients benefited from the operation and three did not.


Fallopian tube surgery for reversal of sterilization. Of 16 consecutive cases of previous sterilization treated by tubal surgery fifteen women tested had patent Fallopian tubes. Over 18 months since operation there were four full-term pregnancies and two abortions among 11 patients. At interview with the patient it is important to emphasize that reconstruction of the tubes is a major operation and carries an increased subsequent hazard of ectopic pregnancy.


B.M.A. deputizing service in Sheffield, 1970. Seventy-four per cent. of Sheffield general practitioners and 78% of those in Nottingham used a deputizing service in 1970. In each city the deputizing service was used by about 80% of single-handed general practitioners, 90% of doctors in two-doctor practices, and 60% of those in partnerships of three or more.The Sheffield deputizing service handled 15,988 new calls in the year, an average of 106 per subscribing doctor, and in addition made 339 revisits. The median number of calls handled for single-handed doctors was 98, for those in two-doctor practices 95, and for those in partnerships of three or more 75. The growth of group practice has not eliminated the demand for deputizing services.Sixty-six per cent. of consultations were with deputies who were primarily hospital doctors, 20% with a full-time deputy, 11% with deputies who were primarily general practitioners, and 3% with the switchboard staff, who were also trained nurses. The deputies had been qualified, on average, for eight years. Seventy-two per cent. of patients attended were seen within one hour of receipt of the call.Calls handled by the deputizing service represented approximately 1% of all the subscribers' consultations, 5% of their home visits, and half their calls between midnight and 07.00 hours. At this level of activity the concept of "personal doctoring" was not threatened.


Clinical medicine and research in France.


Postgastrectomy retroanastomotic hernia.


Predicting survival in terminal cancer.

Predicting survival in terminal cancer.


Rabies.

Rabies.


Graphic records in labour.

Graphic records in labour.


Breech management with fetal blood sampling.


Fluoride and osteoporosis.

Fluoride and osteoporosis.


Hazard of ultrasonic detection of deep vein thrombosis.


Intestinal pseudo-obstruction.

Intestinal pseudo-obstruction.


Obstetric prevention of mental retardation.


Late diagnosis of congenital blindness.

Late diagnosis of congenital blindness.


Fees for cremation certificates.

Fees for cremation certificates.


Hyperactive children.

Hyperactive children.


Mute of malady.

Mute of malady.


Unchecked growth.

Unchecked growth.


Compulsory powers to see case-notes.

Compulsory powers to see case-notes.


Help for victims of immunizations.

Help for victims of immunizations.


Alpha 1  antitrypsin deficiency and liver disease in childhood.


Rheumatoid cervical luxation.

Rheumatoid cervical luxation.


Crossing the gap.

Crossing the gap.


Association between atherosclerotic diseases and carboxyhaemoglobin levels in tobacco smokers. In a cross-sectional study carboxyhaemoglobin (COHb) levels in tobacco smokers were found to provide a better indication of a person's risk of having developed certain atherosclerotic diseases, including ischaemic heart disease, than the smoking history. In the age group 30-69 years a person with a COHb level of 5% or more was found to be 21 times (lower 95% confidence limit 3.3 times) as likely to be affected by these diseases as another person of the same age and sex with similar smoking history and current smoking habits but with a COHb level of less than 3%.


Observations on the epidemiology of simple hypospadias. A descriptive epidemiological study of simple hypospadias-that is, hypospadias without coexisting malformation outside the genital system-in a birth population of 46,927 singleton males and 1,013 twin males showed that the condition was significantly more common (P < 0.001) in uniovular twin males than in either singleton or binovular twin males. Also the temporal distribution of dates of conception had a significant cyclic pattern for each year of the study. Both observations are thought to support the view that gonadotrophin levels at stage 3 sexual organogenesis play an important part in normal masculinization of male external genitalia.


Chronic bronchitis: method of cigarette smoking. Male volunteers for mass radiography examination, aged 40 or more, were questioned about their sputum production, smoking habits, and, when applicable, their method of smoking cigarettes.Of 5,438 cigarette smokers 460 (8.4%) smoked their cigarettes without removing the cigarette from the mouth between puffs ("drooping" cigarette smokers) whereas the rest smoked in the normal manner.Persons who admitted to producing sputum from their chests on most days of the year or on most days for at least three months of the year for a minimum of two years were classified as chronic bronchitics in the absence of other causative disease.The rate of chronic bronchitis among the "drooping" cigarette smokers (41.5%) was considerably greater than that among those smoking cigarettes in the normal manner (33.6%). The same pattern was maintained when age and cigarette consumption were standardized, though "drooping" cigarette smokers had a slight bias towards plain as distinct from filter cigarettes and towards a lower social class this was not sufficient to account for the excess of chronic bronchitis among those using this method of smoking.


Insulinopenic diabetes in Africa.

Insulinopenic diabetes in Africa. The high proportion of unrefined carbohydrates (maize meal) in the diet of Africans could be responsible for their low insulin secretion. The consequent insulinopenia in the general African population may explain the comparative rarity of typical non-insulin dependent diabetes mellitus, and also the virtual absence of coronary heart disease. Changes in growth hormone secretion and in serum lipids, known to be associated with diabetes in Europeans, are also found in African patients.


Behçet's disease with decreased fibrinolysis and superior vena caval occlusion.


Isolation in the control of dysentery.

Isolation in the control of dysentery.


Facial palsy as the sole presenting symptom of parotid carcinoma.


Antibiotic levels in tissue fluid.

Antibiotic levels in tissue fluid.


Surgical implications of some types of drug dependence.


Deputizing services.

Deputizing services.


The placenta--an environmental problem.

The placenta--an environmental problem.


Unconventional publication.

Unconventional publication.


Non-pharmacological influences on therapeutic efficacy.


Hyperinfection with strongyloides in lymphomas.


Poisoning in children.

Poisoning in children.


Assessment of acid-base disturbances.

Assessment of acid-base disturbances.


Road accident prevention.

Road accident prevention.


Abuse of diuretics by jockeys.

Abuse of diuretics by jockeys.


Community physician: a statutory consultant.


Joint Mission Hospital Equipment Board.

Joint Mission Hospital Equipment Board.


Serum IgE elevation with tropical eosinophilia.


Inhibition of reagin-mediated PCA reactions in baboons by the human IgG4 sub-class.


Metabolic changes in exercise-induced asthma.


Lysosomal enzymes of cultured amniotic fluid cells.


The improvement of specificity in radioimmunoassays.


The effect of environmental temperature (20 degrees and 30 degrees) after injury on the concentration of serum proteins in man.


A gas-chromatographic method for the determination of the total CO 2  content in biological fluids, by means of the head space sampling technique, based on the methane conversion principle.


Leucine aminopeptidase isoenzyme changes after treatment with anticonvulsant drugs.


A new colorimetric method for plasma fatty acid analysis.


Spectrofluorimetric determination of individual bile acids in biological fluids: peripheral plasma.


Effect of acetylsalicyclic acid (aspirin) on bone collagen in children.


Cerebrospinal fluid polyols in patients with diabetes mellitus.


Elevated activity of lysosomal enzymes in amniotic fluid of a fetus with mucolipidosis II (I-cell disease).


A simplified general proof of the Allen correction equation and some comments concerning its applicability to the colorimetric analysis of oestriol.


Assessment of foetal lung maturity by amniotic fluid fatty acid analysis.


Many modest goals: the pragmatics of health delivery.


Long term survival following myocardial infarction and ventricular fibrillation.


Control of pain associated with malignant disease by freezing: cryoleucotomy.


The cotton applicator: friend or foe?

The cotton applicator: friend or foe?


What the clinician needs to know about radiology.


What's wrong with medical education?

What's wrong with medical education?


Dispensing regulations.

Dispensing regulations.


Practice management. Forming a group practice.


Comments on "what's wrong with medical education"?


Porcine calcitonin (Calcitare).

Porcine calcitonin (Calcitare).


Transureteroureterostomy.

Transureteroureterostomy.


Leukocyte alkaline phosphatase monitoring of ovarian function in normal and clomiphene-treated cycles. Daily leukocyte alkaline phosphatase activity (LAP), basal body temperature (BBT), fern test (FT) and serum luteinizing hormone (LH) were determined during 15 normal menstrual cycles and 10 cycles treated with clomiphene citrate.  A rise in LAP activity, as determined by LAP-relative score (LAP-RS), was observed during the midcycle period.  This rise reached peak values on the day of serum LH surge in 60% of cycles.  In the remaining cycles, LAP-RS showed peak values 1 day before (8%) or after (32%) LH peak.  The mean LAP-RS peak value in clomiphene treated cycles was 13.2, 5-6 times higher than the basic value.  The low point of the BBT coincided with the LH SURGE in only 32% of cycles.  In 32% the span was more than 1 day before or after LH peak.  The day of ovulation as determined by FT corresponded to the LH surge in only 40% of cycles.  In 20% of cases, the ovulatory FT reponse occurred more than 1 day before or after LH surge.  The results in this study indicated that LAP-RS is a rapid, simple and reliable test for timing of ovulation when carried out daily.  It may be valuable in monitoring follicular activity during human chorionic gonadotropin therapy.


The stimulatory influence of gonadal steroids and methallibure (ICI 33, 828) on peptidase activity in the female rat hypothalamus.


Hypogonadotropism and "empty sella": improvement in 2 cases with clomiphene citrate.


Clinical significance of sperm antibodies in infertile couples.


EGG transport over the fimbrial surface of the rabbit oviduct under experimental conditions.


Activity and localization of isocitric dehydrogenase, aspartate aminotransferase, alanine aminotransferase, alkaline and acid phosphatase of the human vas deferens.


The effects of various steroids on the vaginal histology in the rat.


Long-term follow-up of a patient with congenital adrenal hyperplasia and failure of testicular development.


Chromosome investigation in married couples with repeated spontaneous abortions.


Impact of lepromatous leprosy on fecundity.


On the possible localization of a gene for triosephosphate isomerase on the short arm of human chromosome 5.


Morphological, autoradiographic, immunochemical and cytochemical investigation of a cell strain with trisomy 7 from a spontaneous abortus.


Identification of a D-E(15-18) translocation chromosome by quinacrine fluorescence and urea banding techniques.


XXXX syndrome: case report, and a note on genetic counselling and fertility.


Cystinosis: quantitative assay of cystine accumulation of homozygotes and heterozygotes.